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Sample records for rio red grapefruit

  1. Influence of pre- and post-harvest factors and processing on the levels of furocoumarins in grapefruits (Citrus paradisi Macfed.).

    Science.gov (United States)

    Girennavar, B; Jayaprakasha, G K; Patil, Bhimanagouda S

    2008-11-15

    The changes in the levels of three furocoumarins such as dihydroxybergamottin (DHB), paradisin A and bergamottin in Rio Red and Marsh White cultivars of grapefruits were monitored from November to May. The levels of DHB and bergamottin in both varieties of grapefruits decreased as the season progressed except for the bergamottin in Marsh White grapefruit. Influence of growing location, processing and storage on the levels of these compounds were also evaluated. Among the varieties the highest levels of DHB (2.266μg/ml) and bergamottin (2.411μg/ml) were found in Flame grapefruit grown in Florida. The highest level of paradisin A was found in Rio Red grapefruit grown in California and the lowest levels were observed in Rio Red grapefruit grown organically in Texas. Hand squeezed juice contained 1.98, 1.06 and 3.03-fold more DHB, paradisin A and bergamottin, respectively as compared to processed juice. The levels of furocoumarins showed a decreasing trend in all the juices with progress of storage. Levels of furocoumarins were more in cartons container than the cans and cardboard container juices. Published by Elsevier Ltd.

  2. Radical scavenging activities of Rio Red grapefruits and Sour orange fruit extracts in different in vitro model systems.

    Science.gov (United States)

    Jayaprakasha, G K; Girennavar, Basavaraj; Patil, Bhimanagouda S

    2008-07-01

    Antioxidant fractions from two different citrus species such as Rio Red (Citrus paradise Macf.) and Sour orange (Citrus aurantium L.) were extracted with five different polar solvents using Soxhlet type extractor. The total phenolic content of the extracts was determined by Folin-Ciocalteu method. Ethyl acetate extract of Rio Red and Sour orange was found to contain maximum phenolics. The dried fractions were screened for their antioxidant activity potential using in vitro model systems such as 1,1-diphenyl-2-picryl hydrazyl (DPPH), phosphomolybdenum method and nitroblue tetrazolium (NBT) reduction at different concentrations. The methanol:water (80:20) fraction of Rio Red showed the highest radical scavenging activity 42.5%, 77.8% and 92.1% at 250, 500 and 1000 ppm, respectively, while methanol:water (80:20) fraction of Sour orange showed the lowest radical scavenging activity at all the tested concentrations. All citrus fractions showed good antioxidant capacity by the formation of phosphomolybdenum complex at 200 ppm. In addition, superoxide radical scavenging activity was assayed using non-enzymatic (NADH/phenaxine methosulfate) superoxide generating system. All the extracts showed variable superoxide radical scavenging activity. Moreover, methanol:water (80:20) extract of Rio Red and methanol extract of Sour orange exhibited marked reducing power in potassium ferricyanide reduction method. The data obtained using above in vitro models clearly establish the antioxidant potential of citrus fruit extracts. However, comprehensive studies need to be conducted to ascertain the in vivo bioavailability, safety and efficacy of such extracts in experimental animals. To the best of our knowledge, this is the first report on antioxidant activity of different polar extracts from Rio Red and Sour oranges.

  3. Red Star Ruby (Sunrise) and blond qualities of Jaffa grapefruits and their influence on plasma lipid levels and plasma antioxidant activity in rats fed with cholesterol-containing and cholesterol-free diets.

    Science.gov (United States)

    Gorinstein, Shela; Leontowicz, Hanna; Leontowicz, Maria; Drzewiecki, Jerzy; Jastrzebski, Zenon; Tapia, María S; Katrich, Elena; Trakhtenberg, Simon

    2005-09-23

    Bioactive compounds of peels and peeled red Star Ruby (Sunrise) and blond qualities of Jaffa grapefruits were analyzed and their antioxidant potential was assessed. The dietary fibers were determined according to Prosky et al., the total polyphenol content by Folin-Ciocalteu method and measured at 765 nm, minerals and trace elements by atomic absorption spectrometer, phenolic and ascorbic acids by HPLC and the antioxidant potential by two different antioxidant assays (DPPH and beta-carotene linoleate model system). It was found that the contents of most studied bioactive compounds in both qualities are comparable. Only the contents of total polyphenols and flavonoids were higher in red grapefruits, but not significant. The antioxidant potentials of red peeled grapefruits and their peels were significantly higher than of blond peeled grapefruits and their peels (Pcholesterol added diet. In conclusion, both qualities of Jaffa grapefruits contain high quantities of bioactive compounds, but the antioxidant potential of red grapefruits is significantly higher. Diets supplemented with both qualities of Jaffa grapefruits improve the plasma lipid levels and increase the plasma antioxidant activity, especially in rats fed with cholesterol added diets. Jaffa grapefruits, especially their red Star Ruby quality, could be a valuable supplementation for diseases-preventing diets.

  4. Host status of grapefruit and Valencia oranges for Anastrepha serpentina and Anastrepha ludens (Diptera: Tephritidae).

    Science.gov (United States)

    Mangan, Robert L; Thomas, Donald B; Moreno, Aleena M Tarshis

    2011-04-01

    Anastrepha serpentina (Wiedemann) (Diptera: Tephritidae) is sporadically captured in the Rio Grande Valley of Texas. Although its preferred hosts are in the Sapotaceae family, several varieties of Citrus, including grapefruit and oranges are listed as alternate hosts. Although Mexican fruit fly, Anastrepha ludens (Loew), is known to be a major pest of Citrus, doubt exists as to the status of Citrus as a breeding host for A. serpentina. To evaluate the host status of commercial Citrus for A. serpentina we compared oviposition and development with that of A. ludens under laboratory conditions with 'Rio Red' grapefruit (Citrus paradisi MacFayden) and 'Valencia' oranges [Citrus sinensis (L.) Osbeck] in different stages of maturity. Both fly species oviposited in early season fruit in which the eggs and larvae died in the fruit albedo. Survival of either species to the adult stage occurred in later season grapefruit. In oranges, no A. serpentina larvae survived compared with 150 A. ludens surviving to adults. Survival on both Citrus species was much lower for A. serpentina, only approximately 5% of eggs eclosed into larvae in grapefruit compared with approximatley 50% for A. ludens. In oranges approximately 16% of A. serpentina eggs eclosed compared with approximately 76% for A. ludens. In grapefruit, only one fourth as many A. serpentina larvae survived to the adult stage compared with A. ludens. Additional experiments were performed in a greenhouse on small, caged trees of la coma (Sideroxylon celastrinum H.B.K.), a Texas species of Sapotaceae. The A. serpentina females readily oviposited into these berries and normal adults emerged. The present low incidence of the adults, coupled with the high mortality during development of the larvae, suggests that Texas citrus is unlikely to support a breeding population of A. serpentina.

  5. Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques.

    Science.gov (United States)

    Uckoo, Ram M; Jayaprakasha, Guddadarangavvanahally K; Balasubramaniam, V M; Patil, Bhimanagouda S

    2012-09-01

    Grapefruits (Citrus paradisi Macfad) contain several phytochemicals known to have health maintaining properties. Due to the consumer's interest in obtaining high levels of these phytochemicals, it is important to understand the changes in their levels by common household processing techniques. Therefore, mature Texas "Rio Red" grapefruits were processed by some of the common household processing practices such as blending, juicing, and hand squeezing techniques and analyzed for their phytochemical content by high performance liquid chromatography (HPLC). Results suggest that grapefruit juice processed by blending had significantly (P levels of flavonoids (narirutin, naringin, hesperidin, neohesperidin, didymin, and poncirin) and limonin compared to juicing and hand squeezing. No significant variation in their content was noticed in the juice processed by juicing and hand squeezing. Ascorbic acid and citric acid were significantly (P processed by juicing and blending, respectively. Furthermore, hand squeezed fruit juice had significantly higher contents of dihydroxybergamottin (DHB) than juice processed by juicing and blending. Bergamottin and 5-methoxy-7 gernoxycoumarin (5-M-7-GC) were significantly higher in blended juice compared to juicing and hand squeezing. Therefore, consuming grapefruit juice processed by blending may provide higher levels of health beneficial phytochemicals such as naringin, narirutin, and poncirin. In contrast, juice processed by hand squeezing and juicing provides lower levels of limonin, bergamottin, and 5-M-7-GC. These results suggest that, processing techniques significantly influence the levels of phytochemicals and blending is a better technique for obtaining higher levels of health beneficial phytochemicals from grapefruits. Practical Application:  Blending, squeezing, and juicing are common household processing techniques used for obtaining fresh grapefruit juice. Understanding the levels of health beneficial phytochemicals

  6. Grapefruit

    Science.gov (United States)

    ... seed extract is processed from grapefruit seeds and pulp obtained as a byproduct from grapefruit juice production. ... higher than usual risk for developing breast cancer. Diseases of the heart muscle: Consuming grapefruit juice might ...

  7. Grapefruit and drug interactions.

    Science.gov (United States)

    2012-12-01

    Since the late 1980s, grapefruit juice has been known to affect the metabolism of certain drugs. Several serious adverse effects involving drug interactions with grapefruit juice have been published in detail. The components of grapefruit juice vary considerably depending on the variety, maturity and origin of the fruit, local climatic conditions, and the manufacturing process. No single component accounts for all observed interactions. Other grapefruit products are also occasionally implicated, including preserves, lyophylised grapefruit juice, powdered whole grapefruit, grapefruit seed extract, and zest. Clinical reports of drug interactions with grapefruit juice are supported by pharmacokinetic studies, each usually involving about 10 healthy volunteers, in which the probable clinical consequences were extrapolated from the observed plasma concentrations. Grapefruit juice inhibits CYP3A4, the cytochrome P450 isoenzyme most often involved in drug metabolism. This increases plasma concentrations of the drugs concerned, creating a risk of overdose and dose-dependent adverse effects. Grapefruit juice also inhibits several other cytochrome P450 isoenzymes, but they are less frequently implicated in interactions with clinical consequences. Drugs interacting with grapefruit and inducing serious clinical consequences (confirmed or very probable) include: immunosuppressants, some statins, benzodiazepines, most calcium channel blockers, indinavir and carbamazepine. There are large inter-individual differences in enzyme efficiency. Along with the variable composition of grapefruit juice, this makes it difficult to predict the magnitude and clinical consequences of drug interactions with grapefruit juice in a given patient. There is increasing evidence that transporter proteins such as organic anion transporters and P-glycoprotein are involved in interactions between drugs and grapefruit juice. In practice, numerous drugs interact with grapefruit juice. Although only a few

  8. Comportamento de seis variedades de pomelo (Citrus paradisi Macfad. cultivadas sob irrigação na região semi-árida de Pernambuco Behavior of six grapefruit varieties grown under irrigation at the semi-arid region of Pernambuco - Brazil

    Directory of Open Access Journals (Sweden)

    Ildo Eliezer Lederman

    2005-08-01

    Full Text Available O uso da irrigação nas regiões semi-áridas do Nordeste brasileiro tem viabilizado o cultivo comercial de inúmeras fruteiras, tais como a uva, a manga, a goiaba, o coco e a banana. Outras espécies, como o pomelo, ou grapefruit, vêm sendo ainda objeto de estudos e avaliações. Uma coleção formada de 06 variedades de pomelos (Citrus paradisi, de polpas com coloração rosa-avermelhada ('Marsh Foster', 'Star Ruby', 'Rio Red' e 'Red Blush' e amarelada ('Triumph' e 'Marsh Foster Nucelar', foi implantada em 1993 na Estação Experimental de Ibimirim, localizada no município de Ibimirim, no Vale do Rio Moxotó - região semi-árida de Pernambuco. Contando com cinco plantas por parcela, a coleção foi conduzida sob irrigação localizada e as avaliações realizadas durante três anos (2000 a 2002. Os resultados demostraram alta variabilidade na produção de frutos, tendo a variedade 'Marsh Foster Nucelar' alcançado a produção média de 135,0 kg/planta, enquanto a 'Star Ruby' atingiu apenas 31,0 kg/planta. O peso médio dos frutos variou de 285,5g ('Red Blush' até um máximo de 401,6g na variedade 'Triumph'. O volume de suco extraído, os sólidos solúveis totais (SST, a acidez total titulável (ATT e a relação SSS/ATT também apresentaram mudanças entre as variedades estudadas.The use of irrigation at the semi-arid region of Northeast Brazil has made feasible several commercial fruit trees crops such as grapevines, mango, guava, coconut, banana and others, like grapefruit, which actually is being studied. A collection formed by six grapefruit varieties showing a pink-red pulp color (Marsh Foster, Star Ruby, Rio Red and Red Blush and a creamy color (Triumph and Marsh Foster Nucelar and consisting of five plants/plot was installed in 1993 at the Ibimirim Experimental Station, located in the Moxotó river valley at the semi-arid region of Pernambuco - Northeast Brazil, under irrigation. Evaluations carried out during three years (from

  9. Host status of grapefruit and Valencia oranges for Anastrepha serpentina and Anastrepha ludens

    Science.gov (United States)

    Anastrepha serpentina, known as the zapote fly or serpentine fruit fly, is occasionally captured in the Rio Grande Valley of Texas. Lists of host plants for this species include several species of citrus, such as oranges and grapefruit. Current regulatory procedures require quarantines and treatme...

  10. 21 CFR 146.132 - Grapefruit juice.

    Science.gov (United States)

    2010-04-01

    ... in the finished food. The grapefruit pulp, grapefruit oil, and grapefuit essence (components derived... paragraph (a)(2) of this section. Grapefruit juice, as defined in this paragraph, may be preserved by heat... sirup, dextrose, glucose sirup, and fructose. Sweeteners defined in part 168 of this chapter shall be as...

  11. Absorption and pharmacokinetics of grapefruit flavanones in beagles

    OpenAIRE

    Mata Bilbao, María de Lourdes; Andrés Lacueva, Ma. Cristina; Roura Carvajal, Elena; Jáuregui Pallarés, Olga; Escribano Ferrer, Elvira; Torre, Celina; Lamuela Raventós, Rosa Ma.

    2007-01-01

    The present study evaluated the pharmacokinetics of three different grapefruit flavanone forms in dog plasma and demonstrated their absorption after an oral intake of a grapefruit extract; pharmacokinetic parameters of these forms were also determined. Ten healthy beagles were administered 70 mg citrus flavonoids as a grapefruit extract contained in capsules, while two additional dogs were used as controls and given an excipient. The grapefruit flavanone naringin, along with its metabolites n...

  12. Hidden sources of grapefruit in beverages: potential interactions with immunosuppressant medications.

    Science.gov (United States)

    Auten, Ashley A; Beauchamp, Lauren N; Joshua Taylor; Hardinger, Karen L

    2013-06-01

    The interaction between grapefruit-containing beverages and immunosuppressants is not well defined in the literature. This study was conducted to investigate possible sources of grapefruit juice or grapefruit extract in common US-manufactured beverages. The goal was to identify those products that might serve as hidden sources of dietary grapefruit intake, increasing a transplant patient's risk for drug interactions. A careful review of the ingredients of the 3 largest US beverage manufacturer's product lines was conducted through manufacturer correspondence, product labeling examination, and online nutrition database research. Focus was placed on citrus-flavored soft drinks, teas, and juice products and their impact on a patient's immunosuppressant regimens. Twenty-three beverages were identified that contained grapefruit. Five did not contain the word "grapefruit" in the product name. In addition to the confirmed grapefruit-containing products, 17 products were identified as possibly containing grapefruit juice or grapefruit extract. A greater emphasis should be placed upon properly educating patients regarding hidden sources of grapefruit in popular US beverages and the potential for food-drug interactions.

  13. Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients.

    Science.gov (United States)

    Bailey, D G; Dresser, G K; Kreeft, J H; Munoz, C; Freeman, D J; Bend, J R

    2000-11-01

    To determine whether unprocessed grapefruit can cause a drug interaction, whether the active ingredients are naturally occurring, and whether specific furanocoumarins or flavonoids are involved. The oral pharmacokinetics of felodipine and its dehydrofelodipine metabolite were determined after administration of felodipine 10 mg extended-release tablet with 250 mL commercial grapefruit juice, homogenized grapefruit segments, or extract of segment-free parts equivalent to one unprocessed fruit or water in a randomized four-way crossover study. Inhibition of recombinant CYP3A4 by furanocoumarins (bergamottin, 6',7'-epoxybergamottin, 6',7'-dihydroxybergamottin) and flavonoids (naringenin optical isomers) was determined. Furanocoumarin and naringenin precursor (naringin) concentrations were measured in each grapefruit treatment. Felodipine AUC with commercial grapefruit juice, grapefruit segments, or grapefruit extract was on average 3-fold higher than that with water. Felodipine peak concentration was higher, but the half-life was unchanged. The dehydrofelodipine/felodipine AUC ratio was reduced. The furanocoumarins produced mechanism-based and competitive inhibition of CYP3A4. Bergamottin was the most potent mechanism-based inhibitor. Naringenin isomers produced only competitive inhibition. Bergamottin, 6',7'-dihydroxybergamottin, and naringin concentrations varied among grapefruit treatments but were sufficient to inhibit markedly in vitro CYP3A4 activity. Unprocessed grapefruit can cause a drug interaction with felodipine. The active ingredients are naturally occurring in the grapefruit. Bergamottin is likely important in drug interactions with commercial grapefruit juice. 6',7'-Dihydroxybergamottin and naringin may be more important in grapefruit segments because they are present in higher concentrations. Any therapeutic concern for a drug interaction with commercial grapefruit juice should now be extended to include whole fruit and possibly confectioneries made

  14. 78 FR 24329 - Oranges and Grapefruit Grown in Lower Rio Grande Valley in Texas; Increased Assessment Rate

    Science.gov (United States)

    2013-04-25

    ... the marketing order now in effect, orange and grapefruit handlers are subject to assessments. Funds to... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 906 [Doc. No. AMS-FV-12-0038... Rate AGENCY: Agricultural Marketing Service, USDA. ACTION: Final rule. SUMMARY: This rule increases the...

  15. 7 CFR 905.306 - Orange, Grapefruit, Tangerine and Tangelo Regulation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Orange, Grapefruit, Tangerine and Tangelo Regulation... AGRICULTURE ORANGES, GRAPEFRUIT, TANGERINES, AND TANGELOS GROWN IN FLORIDA Grade and Size Requirements § 905.306 Orange, Grapefruit, Tangerine and Tangelo Regulation. (a) During the period specified in column (2...

  16. Red Mexican grapefruit: a novel source for bioactive limonoids and their antioxidant activity.

    Science.gov (United States)

    Mandadi, Kranthi K; Jayaprakasha, Guddadarangavvanahally K; Bhat, Narayan G; Patil, Bhimanagouda S

    2007-01-01

    Citrus limonoids have shown to inhibit the growth of cancer in colon, lung, mouth, stomach and breast in animal and cell culture studies. For the first time in the present study, an attempt has been made to isolate antioxidant fractions and five limonoids from red Mexican grapefruit seeds. Defatted seed powder was successively extracted with hexane, ethyl acetate (EtOAc), acetone, methanol (MeOH) and MeOH/water and the extracts were concentrated under vacuum. Radical scavenging activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and total phenolic content were also measured for comparison with the antioxidant capacity in the phosphomolybdenum method for the above extracts. Acetone and MeOH extracts, respectively, showed the highest (85.7%) and lowest (53.3%) radical scavenging activity, at 500 ppm. The total phenolic contents were found to be highest in the acetone extract (15.94%) followed by the MeOH extract (5.92%), ethyl acetate extract (5.54%) and water extract (5.26%). Antioxidant capacity of the extracts as equivalents to ascorbic acid (micromol/g of the extract) was in the order, EtOAc extract > acetone extract > water extract > methanol extract. Furthermore, the EtOAC and acetone extracts were loaded onto silica gel columns to obtain four limonoid aglycons. MeOH fraction was loaded onto a dowex-50 and sepabeads resin column to obtain a limonoid glucoside. The purity of the isolated five compounds was analyzed by HPLC using a C18 column and UV detection at 210 nm. Finally, the structures of the compounds were identified as obacunone, nomilin, limonin, deacetylnomilin (DAN) and limonin-17-beta-D-glucopyranoside (LG) using 1H and 13C NMR studies.

  17. 77 FR 51750 - United States Standards for Grades of Grapefruit Juice

    Science.gov (United States)

    2012-08-27

    ... standards in order to encourage uniformity and consistency in commercial practices.'' AMS is committed to... Grapefruit Juice. The petitioner requested the removal of the maximum limit for ``free and suspended pulp... concentrate, grapefruit juice, and frozen concentrated grapefruit juice establish limits for maximum free and...

  18. Effects of γ-irradiation on β-pinene content and germination in grapefruit

    International Nuclear Information System (INIS)

    Uchiyama, Sadao; Kawamura, Yoko; Saito, Yukio; Nagashima, Kimiyo.

    1988-01-01

    Effects of γ-irradiation on β-pinene content and germination in grapefruit were investigated in order to develop a method to identify γ-irradiated grapefruit. β-Pinene is a component of essential oil in grapefruit and was reported to be susceptible to γ-irradiation. However, it was not degraded by irradiation (30 to 200 krad) in this experiment. When grapefruit irradiated at 50 krad were stored at 10degC for 2 months, no change of β-pinene content was found. β-Pinene itself was also stable to γ-irradiation at 1 Mrad. Thus, identification of irradiated grapefruit from the amount of β-pinene was impossible. On the other hand, the effect of γ-irradiation on radicle elongation was small but that on plumule expansion was so large as to prevent shooting in grapefruit irradiated even at 30 krad. Therefore it should be possible to identify γ-irradiated grapefruit by a germination method. (author)

  19. 6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect.

    Science.gov (United States)

    Kakar, Shefali M; Paine, Mary F; Stewart, Paul W; Watkins, Paul B

    2004-06-01

    Our objective was to assess the contribution of 6',7'-dihydroxybergamottin (DHB) to the inhibitory effect of grapefruit juice toward intestinal cytochrome P450 (CYP) 3A4. An aqueous extract was prepared from grapefruit juice by centrifugation, filtration, and repeated washing of the particulate with water. The concentrations of various furanocoumarins in this grapefruit juice "serum" and in whole grapefruit juice were measured by HPLC and their identities confirmed by liquid chromatography-tandem mass spectrometry. Five healthy volunteers were given a single tablet of felodipine (10 mg) with whole grapefruit juice, orange juice-containing serum, or plain orange juice (control). The pharmacokinetic outcomes of felodipine were evaluated by noncompartmental methods. The effects of serum and purified DHB (at the same concentrations as those measured in the orange juice-containing serum used in the clinical study) were compared, in vitro, with regard to (1) the reversible and mechanism-based inhibition of the catalytic activity of complementary deoxyribonucleic acid-expressed CYP3A4 and (2) the time-dependent loss of immunoreactive CYP3A4 protein in modified Caco-2 cells. The concentration of DHB in serum was comparable to that measured in whole grapefruit juice (38 micromol/L versus 43 micromol/L), and the concentrations of other known furanocoumarins were well below the lowest published concentration required to inhibit catalytic activity by 50%. Relative to plain orange juice, orange juice-containing serum significantly increased the median felodipine area under the plasma concentration-time curve by 1.9-fold (P =.04) and increased the maximum concentration by 1.7-fold (P =.01). In vitro, serum and purified DHB had similar inhibitory effects toward CYP3A4 activity with respect to both reversible inhibition (95% confidence interval, 85% +/- 5.7% and 75% +/- 4.5%, respectively) and mechanism-based inhibition after a 15-minute preincubation (95% confidence interval, 79

  20. Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel.

    Science.gov (United States)

    Wangensteen, H; Molden, E; Christensen, H; Malterud, K E

    2003-02-01

    The oral availability of many drugs metabolised by the enzyme cytochrome P(450) 3A4 (CYP3A4) is increased if co-administered with grapefruit juice. Extracts from grapefruit peel have also demonstrated inhibitory activity and, during commercial manufacturing of grapefruit juice, inhibitory components might be squeezed into the juice from the peel. Thus, the aim of this in vitro study was to identify CYP3A4 inhibitors in grapefruit peel. Grapefruit peel was extracted with diethyl ether, and the extract was further fractionated by normal-phase chromatography. Fractions demonstrating significant CYP3A4 inhibitory activity, as measured by the relative reduction in N-demethylation of diltiazem in transfected human liver epithelial cells, were subsequently separated by preparative thin-layer chromatography. Constituents of the fractions and isolated compounds were identified by nuclear magnetic resonance spectroscopy. Analysis of diltiazem and N-demethyl-diltiazem was performed using high-performance liquid chromatography. Of the identified components in grapefruit peel, only epoxybergamottin demonstrated a concentration-dependent inhibition of the CYP3A4-mediated N-demethylation of diltiazem. The IC(50) value was calculated to be 4.2+/-1.1 micro M. Coumarins without the furan ring and flavonoids isolated from grapefruit peel did not interfere with the metabolism of diltiazem. The results indicated the presence of other CYP3A4 inhibitors in grapefruit peel, but these agents were lost during the purification process excluding their identification. The furanocoumarin epoxybergamottin, present in grapefruit peel, is an inhibitor of CYP3A4. In commercial manufacturing of grapefruit juice, epoxybergamottin is possibly distributed into the juice. During manufacturing, however, epoxybergamottin may be hydrolysed to 6',7'-dihydroxybergamottin, which has been suggested as an important CYP3A4 inhibitor in grapefruit juice.

  1. In vitro plant regeneration in rough lemon (Citrus jambhiri Lush) by ...

    African Journals Online (AJOL)

    Jane

    2011-10-17

    Oct 17, 2011 ... H S Rattanpal*1, Gagandeep Kaur2 and Monika Gupta2 ... Seeds were extracted from ripe fruits of rough lemon. ... extract and additional dose of 25 g/l sucrose. ..... important grapefruit cultivar Rio Red (Citrus paradise Macf.).

  2. Absorption and pharmacokinetics of grapefruit flavanones in beagles.

    Science.gov (United States)

    Mata-Bilbao, Maria de Lourdes; Andrés-Lacueva, Cristina; Roura, Elena; Jáuregui, Olga; Escribano, Elvira; Torre, Celina; Lamuela-Raventós, Rosa Maria

    2007-07-01

    The present study evaluated the pharmacokinetics of three different grapefruit flavanone forms in dog plasma and demonstrated their absorption after an oral intake of a grapefruit extract; pharmacokinetic parameters of these forms were also determined. Ten healthy beagles were administered 70 mg citrus flavonoids as a grapefruit extract contained in capsules, while two additional dogs were used as controls and given an excipient. The grapefruit flavanone naringin, along with its metabolites naringenin and naringenin glucuronide, was detected in dog plasma. Blood samples were collected between 0 and 24 h after administration of the extract. Naringin reached its maximun plasma concentration at around 80 min, whereas naringenin and naringenin glucuronide reached their maximun plasma concentrations at around 20 and 30 min, respectively. Maximum plasma concentrations of naringin, naringenin and naringenin glucuronide (medians and ranges) were 0.24 (0.05-2.08), 0.021 (0.001-0.3) and 0.09 (0.034-0.12) micromol/l, respectively. The areas under the curves were 23.16 l (14.04-70.62) min x micromol/for nariningin, 1.78 (0.09-4.95) min x micromol/l for naringenin and 22.5 (2.74-99.23) min x micromol/l for naringenin glucuronide. The median and range values for mean residence time were 3.3 (1.5-9.3), 2.8 (0.8-11.2) and 8.0 (2.3-13.1) h for naringin, naringenin and naringenin glucuronide, respectively. The results of the present study demonstrate the absorption of grapefruit flavanones via the presence of their metabolites in plasma, thus making an important contribution to the field since the biological activities ascribed to these compounds rely on their specific forms of absorption.

  3. Medicinal importance of grapefruit juice and its interaction with various drugs

    Directory of Open Access Journals (Sweden)

    Imam Sardar Z

    2007-10-01

    Full Text Available Abstract Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P – 450 3A4 system, which is responsible for the first pass metabolism of many drugs. The P – glycoprotein pump, found in the brush border of the intestinal wall which transports many of these cytochrome P – 450 3A4 substrates, has also been implicated to be inhibited by grapefruit juice. By inhibiting these enzyme systems, grapefruit juice alters the pharmacokinetics of a variety of medications, leading to elevation of their serum concentrations. Most notable are its effects on the calcium channel antagonist and the statin group of drugs. In the case of many drugs, the increased serum concentration has been found to be associated with increased frequency of dose dependent adverse effects. In this review, we have discussed the phytochemistry of grapefruit juice, the various drugs involved in the drug – grapefruit juice eraction with their mechanisms of action and have presented the clinical implications of these interactions.

  4. Antioxidant activity and antiaging gel formulation grapefruit peel (Citrus maxima Merr.) ethanolic extract

    OpenAIRE

    Nazliniwaty; Karsono; Zebua, Nilsya Febrika; Febrika, Nilsya

    2017-01-01

    This study aims to conduct the antioxidant activity test of grapefruit peel ethanolic extracts and gel formulation. Grapefruit (Citrus maxima Merr.) is a plant of the Rutaceae family, which has been known to contain ph enolic compounds (flavonoids and tannins). Grapefruit skin was very thick (>30% of the total weight of the fr uit) and always considered as waste that has not been utiliz ed properly....

  5. Grapefruit Pamplemousse

    Directory of Open Access Journals (Sweden)

    Catharine Savage Brosman

    2007-01-01

    Full Text Available Tossing a grapefruit in the air to catch it, as I skippast squash and eggplants to my shopping cart,I can imagine juggling two or three—just possible, perhaps—or five or six: why not,since it’s a fantasy? Or holding like a godone golden planet, as I swing, beneath a tentof stars, from a trapeze, then pitch the orb,a flaming meteorite, in softball fashionto another acrobat below. Or even, most amazing,tightrope-walking, with a grapefruitin each hand as balance, and the crowd in silence,breathl...

  6. 7 CFR 319.56-44 - Untreated grapefruit, sweet oranges, and tangerines from Mexico for processing.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Untreated grapefruit, sweet oranges, and tangerines... QUARANTINE NOTICES Fruits and Vegetables § 319.56-44 Untreated grapefruit, sweet oranges, and tangerines from Mexico for processing. Untreated grapefruit (Citrus paradisi), sweet oranges (Citrus sinensis), and...

  7. Biosynthesis of Silver and Gold Crystals Using Grapefruit Extract

    OpenAIRE

    Chen Long; Wang Jianli; Wang Hongfeng; Qi Zhaopeng; Zheng Yuchuan; Wang Junbo; Pan Le; Chang Guanru; Yang Yongmei

    2016-01-01

    In this paper, biological synthesis of silver and gold crystals using grapefruit extract is reported. On treatment of aqueous solutions of silver nitrate and chloroauric acid with grapefruit extract, the formation of stable silver and gold particles at high concentrations is observed to occur. The silver particles formed are quasi-spherical or irregular with sizes ranging from several hundred nanometers to several microns. The gold quasi-spheres with holes on surfaces and with diameters rangi...

  8. Qualidade pós-colheita de pomelos (Citrus paradisi Macf. produzidos em plantações iniciais no estado do Ceará, Brasil Postharvest quality of grapefruit (Citrus paradisi Macf. produced from initial plantings in Ceará state, Brazil

    Directory of Open Access Journals (Sweden)

    Francisca Ligia de Castro Machado

    2011-12-01

    Full Text Available O estado do Ceará, nordeste do Brasil, vem ganhando atenção como o mais emergente Estado produtor de frutos no país. Citros, incluindo pomelos, tradicionalmente cultivados no sul, vem sendo plantados no Estado. No entanto, ainda não existem informações sobre qualidade de pomelos cultivados localmente. Este estudo objetivou examinar a qualidade pós-colheita de pomelos 'Star Ruby' e 'Ruby Red' quanto ao tamanho e forma, coloração da polpa, espessura da casca, rendimento do suco, sólidos solúveis (SS, acidez titulável (AT, pH, relação SS/AT e níveis de ácido ascórbico na colheita e após 15 dias de armazenamento. Um segundo lote de frutos foi examinado quanto a perda de massa e coloração externa. Os resultados sugerem que os pomelos apresentam bom tamanho e forma, com coloração externa alaranjada e interna avermelhada e espessura da casca apropriada. Frutos apresentaram um bom rendimento de suco, rico em ácido ascórbico, e com valores de SS, AT e pH comparáveis aos reportados para frutos cultivados em áreas tradicionais do país. A relação SS/AT encontra-se acima do mínimo necessário para um bom sabor. A coloração da casca variou de amarelado a alaranjado. Perda de massa aumentou, enquanto o ângulo de cor hue decresceu, seguindo o mesmo padrão para as duas variedades.Ceará state, northeast Brazil, is gaining attention as the most significant emerging fruit production region in the country. Citrus, including grapefruit, traditionally cultivated in the south, was recently implanted. However, data on postharvest quality of grapefruit grown under local conditions are nonexistent. A study was designed to examine postharvest quality of locally grown 'Star Ruby' and 'Ruby Red' grapefruits. Fruits were assessed for size and shape, pulp color, peel thickness, juice content, soluble solids (SS, titratable acidity (TA, pH, SS/TA ratio, and ascorbic acid at harvest and at the fifteenth day of storage. A second set of fruits

  9. Quantitation of Rotundone in Grapefruit (Citrus paradisi) Peel and Juice by Stable Isotope Dilution Assay.

    Science.gov (United States)

    Nakanishi, Akira; Fukushima, Yusuke; Miyazawa, Norio; Yoshikawa, Keisuke; Maeda, Tomoko; Kurobayashi, Yoshiko

    2017-06-21

    Aroma extract dilution analyses of the aromas of peels and juices of white and pink grapefruits revealed that rotundone, responsible for peppery, spicy, and woody odors, was detected for the first time at high flavor dilution factors of 256-1024. In both juices, rotundone was detected at the highest flavor dilution factor of 1024. Rotundone in grapefruits was quantitated by a stable isotope dilution assay with a newly synthesized deuterium-labeled internal standard, rotundone-d 2,3 : its levels were 2180 and 1920 ng/kg in white and pink grapefruit peels and 29.6 and 49.8 ng/kg in white and pink grapefruit juices, respectively. On the basis of these results, sensory analysis was performed to assess the effects of rotundone on a white grapefruit juice aroma reconstitute. This sensory analysis revealed that rotundone does not impart a woody odor or affect any of the existing attributes, but increases various attributes, thus confirming that rotundone is indispensable for the aroma of grapefruit juice.

  10. Does dietary inulin affect biological activity of a grapefruit flavonoid-rich extract?

    Science.gov (United States)

    Jurgoński, Adam; Juśkiewicz, Jerzy; Kowalska, Karolina; Zduńczyk, Zenon

    2012-04-11

    The aim of the study was to verify that the concomitant presence of grapefruit flavonoid extract with inulin in a Western-type diet may provide synergistic effects to the hindgut metabolism, as well as blood lipid and mineral profiles. Forty male Wistar rats were distributed into 4 groups and fed for 28 days with diets rich in fat, cholesterol and protein. A two-way repeated measures ANOVA was applied to assess the effects of inulin (v. sucrose, 5% of the diet), the addition of dietary grapefruit flavonoid extract (diets without or with 0.3% of an extract from hard parts of grapefruit) and the interaction between these two dietary factors. When compared to the control sucrose-containing diet, the diet enriched with inulin led to typical changes within the caecum, the main part of hindgut fermentation in rats, such as acidification of the digesta, support of bifidobacteria growth and increase of propionate and butyrate production. The dietary grapefruit flavonoid extract without inulin increased the bulk and pH value of caecal digesta, whereas short-chain fatty acid concentration and the bifidobacteria population were lowered compared to the extract-free diets. Simultaneous dietary addition of both tested components decreased slightly the pH value and increased somewhat the bifidobacteria number and the propionate concentration, however to the level observed with the control sucrose-containing diet. With regard to blood lipids, dietary grapefruit flavonoid extract decreased the triglyceride concentration regardless of the dietary carbohydrate type. Inulin does not provide any additional benefit to the blood lipid profile caused by the dietary application of grapefruit flavonoid extract and it does not counteract clearly detrimental effects of the extract in the hindgut. Adding grapefruit extract to the diet must be performed with caution due to possible adverse hindgut responses with overdoses.

  11. Does dietary inulin affect biological activity of a grapefruit flavonoid-rich extract?

    Directory of Open Access Journals (Sweden)

    Jurgoński Adam

    2012-04-01

    Full Text Available Abstract Background The aim of the study was to verify that the concomitant presence of grapefruit flavonoid extract with inulin in a Western-type diet may provide synergistic effects to the hindgut metabolism, as well as blood lipid and mineral profiles. Methods Forty male Wistar rats were distributed into 4 groups and fed for 28 days with diets rich in fat, cholesterol and protein. A two-way repeated measures ANOVA was applied to assess the effects of inulin (v. sucrose, 5% of the diet, the addition of dietary grapefruit flavonoid extract (diets without or with 0.3% of an extract from hard parts of grapefruit and the interaction between these two dietary factors. Results When compared to the control sucrose-containing diet, the diet enriched with inulin led to typical changes within the caecum, the main part of hindgut fermentation in rats, such as acidification of the digesta, support of bifidobacteria growth and increase of propionate and butyrate production. The dietary grapefruit flavonoid extract without inulin increased the bulk and pH value of caecal digesta, whereas short-chain fatty acid concentration and the bifidobacteria population were lowered compared to the extract-free diets. Simultaneous dietary addition of both tested components decreased slightly the pH value and increased somewhat the bifidobacteria number and the propionate concentration, however to the level observed with the control sucrose-containing diet. With regard to blood lipids, dietary grapefruit flavonoid extract decreased the triglyceride concentration regardless of the dietary carbohydrate type. Conclusion Inulin does not provide any additional benefit to the blood lipid profile caused by the dietary application of grapefruit flavonoid extract and it does not counteract clearly detrimental effects of the extract in the hindgut. Adding grapefruit extract to the diet must be performed with caution due to possible adverse hindgut responses with overdoses.

  12. Bioactive Flavonoids, Antioxidant Behaviour, and Cytoprotective Effects of Dried Grapefruit Peels (Citrus paradisi Macf.)

    Science.gov (United States)

    Castro-Vazquez, Lucia; Alañón, María Elena; Rodríguez-Robledo, Virginia; Pérez-Coello, María Soledad; Hermosín-Gutierrez, Isidro; Díaz-Maroto, María Consuelo; Jordán, Joaquín; Galindo, María Francisca; Arroyo-Jiménez, María del Mar

    2016-01-01

    Grapefruit (Citrus paradisi Macf.) is an important cultivar of the Citrus genus which contains a number of nutrients beneficial to human health. The objective of the present study was to evaluate changes in bioactive flavonoids, antioxidant behaviour, and in vitro cytoprotective effect of processed white and pink peels after oven-drying (45°C–60°C) and freeze-drying treatments. Comparison with fresh grapefruit peels was also assessed. Significant increases in DPPH, FRAPS, and ABTS values were observed in dried grapefruit peel samples in comparison with fresh peels, indicating the suitability of the treatments for use as tools to greatly enhance the antioxidant potential of these natural byproducts. A total of thirteen flavonoids were quantified in grapefruit peel extracts by HPLC-MS/MS. It was found that naringin, followed by isonaringin, was the main flavonoid occurring in fresh, oven-dried, and freeze-dried grapefruit peels. In vivo assay revealed that fresh and oven-dried grapefruit peel extracts (45°C) exerted a strong cytoprotective effect on SH-SY5Y neuroblastoma cell lines at concentrations ranging within 0.1–0.25 mg/mL. Our data suggest that grapefruit (Citrus paradisi Macf.) peel has considerable potential as a source of natural bioactive flavonoids with outstanding antioxidant activity which can be used as agents in several therapeutic strategies. PMID:26904169

  13. Food, feeding, and refuelling of Red Knots during northward migration at San Antonio Oeste, Rio Negro, Argentina

    NARCIS (Netherlands)

    Gonzalez, PM; Piersma, T; Verkuil, Y; González, Patricia M.

    1996-01-01

    We studied the food and feeding ecology of Red Knots Calidris canutus rufa on an area of rocky flat, or restinga, near San Antonio Oeste in the northwest of Golfo San Matias, Provincia de Rio Negro, Argentina in March 1992. These Red Knots are on their way north, from ''wintering'' areas in Tierra

  14. Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice

    DEFF Research Database (Denmark)

    Andersen, Vibeke; Pedersen, Natalie; Larsen, Niels-Erik

    2002-01-01

    Grapefruit juice inhibits CYP3A4 in the intestinal wall leading to a reduced intestinal first pass metabolism and thereby an increased oral bioavailability of certain drugs. For example, it has been shown that the oral bioavailability of midazolam, a CYP3A4 substrate, increased by 52% in healthy...... subjects after ingestion of grapefruit juice. However, this interaction has not been studied in patients with impaired liver function. Accordingly, the effect of grapefruit juice on the AUC of midazolam and the metabolite alpha-hydroxymidazolam was studied in patients with cirrhosis of the liver....

  15. Analysis of ethylene biosynthesis and perception during postharvest cold storage of Marsh and Star Ruby grapefruits.

    Science.gov (United States)

    Lado, Joanna; Rodrigo, María Jesús; Zacarías, Lorenzo

    2015-10-01

    Grapefruits are among the citrus species more sensitive to cold and develop chilling injury symptoms during prolonged postharvest storage at temperatures lower than 8 ℃-10 ℃. The plant hormone ethylene has been described either to protect or potentiate chilling injury development in citrus whereas little is known about transcriptional regulation of ethylene biosynthesis, perception and response during cold storage and how the hormone is regulating its own perception and signaling cascade. Then, the objective of the present study was to explore the transcriptional changes in the expression of ethylene biosynthesis, receptors and response genes during cold storage of the white Marsh and the red Star Ruby grapefruits. The effect of the ethylene action inhibitor, 1-MCP, was evaluated to investigate the involvement of ethylene in the regulation of the genes of its own biosynthesis and perception pathway. Ethylene production was very low at the harvest time in fruits of both varieties and experienced only minor changes during storage. By contrast, inhibition of ethylene perception by 1-MCP markedly induced ethylene production, and this increase was highly stimulated during shelf-life at 20 ℃, as well as transcription of ACS and ACO. These results support the auto-inhibitory regulation of ethylene in grapefruits, which acts mainly at the transcriptional level of ACS and ACO genes. Moreover, ethylene receptor1 and ethylene receptor3 were induced by cold while no clear role of ethylene was observed in the induction of ethylene receptors. However, ethylene appears to be implicated in the transcriptional regulation of ERFs both under cold storage and shelf-life. © The Author(s) 2014.

  16. Helichrysum and grapefruit extracts inhibit carbohydrate digestion and absorption, improving postprandial glucose levels and hyperinsulinemia in rats.

    Science.gov (United States)

    de la Garza, Ana Laura; Etxeberria, Usune; Lostao, María Pilar; San Román, Belén; Barrenetxe, Jaione; Martínez, J Alfredo; Milagro, Fermín I

    2013-12-11

    Several plant extracts rich in flavonoids have been reported to improve hyperglycemia by inhibiting digestive enzyme activities and SGLT1-mediated glucose uptake. In this study, helichrysum ( Helichrysum italicum ) and grapefruit ( Citrus × paradisi ) extracts inhibited in vitro enzyme activities. The helichrysum extract showed higher inhibitory activity of α-glucosidase (IC50 = 0.19 mg/mL) than α-amylase (IC50 = 0.83 mg/mL), whereas the grapefruit extract presented similar α-amylase and α-glucosidase inhibitory activities (IC50 = 0.42 mg/mL and IC50 = 0.41 mg/mL, respectively). Both extracts reduced maltose digestion in noneverted intestinal sacs (57% with helichrysum and 46% with grapefruit). Likewise, both extracts inhibited SGLT1-mediated methylglucoside uptake in Caco-2 cells in the presence of Na(+) (56% of inhibition with helichrysum and 54% with grapefruit). In vivo studies demonstrated that helichrysum decreased blood glucose levels after an oral maltose tolerance test (OMTT), and both extracts reduced postprandial glucose levels after the oral starch tolerance test (OSTT). Finally, both extracts improved hyperinsulinemia (31% with helichrysum and 50% with grapefruit) and HOMA index (47% with helichrysum and 54% with grapefruit) in a dietary model of insulin resistance in rats. In summary, helichrysum and grapefruit extracts improve postprandial glycemic control in rats, possibly by inhibiting α-glucosidase and α-amylase enzyme activities and decreasing SGLT1-mediated glucose uptake.

  17. Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) polyphenols

    Science.gov (United States)

    Nobile, Vincenzo; Michelotti, Angela; Cestone, Enza; Caturla, Nuria; Castillo, Julián; Benavente-García, Obdulio; Pérez-Sánchez, Almudena; Micol, Vicente

    2016-01-01

    Background Plant polyphenols have been found to be effective in preventing ultraviolet radiation (UVR)-induced skin alterations. A dietary approach based of these compounds could be a safe and effective method to provide a continuous adjunctive photoprotection measure. In a previous study, a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) extracts has exhibited potential photoprotective effects both in skin cell model and in a human pilot trial. Objective We investigated the efficacy of a combination of rosemary (R. officinalis) and grapefruit (C. paradisi) in decreasing the individual susceptibility to UVR exposure (redness and lipoperoxides) and in improving skin wrinkledness and elasticity. Design A randomised, parallel group study was carried out on 90 subjects. Furthermore, a pilot, randomised, crossover study was carried out on five subjects. Female subjects having skin phototype from I to III and showing mild to moderate chrono- or photoageing clinical signs were enrolled in both studies. Skin redness (a* value of CIELab colour space) after UVB exposure to 1 minimal erythemal dose (MED) was assessed in the pilot study, while MED, lipoperoxides (malondialdehyde) skin content, wrinkle depth (image analysis), and skin elasticity (suction and elongation method) were measured in the main study. Results Treated subjects showed a decrease of the UVB- and UVA-induced skin alterations (decreased skin redness and lipoperoxides) and an improvement of skin wrinkledness and elasticity. No differences were found between the 100 and 250 mg extracts doses, indicating a plateau effect starting from 100 mg extracts dose. Some of the positive effects were noted as short as 2 weeks of product consumption. Conclusions The long-term oral intake of Nutroxsun™ can be considered to be a complementary nutrition strategy to avoid the negative effects of sun exposure. The putative mechanism for these effects is most likely to take place through the

  18. Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis and grapefruit (Citrus paradisi polyphenols

    Directory of Open Access Journals (Sweden)

    Vincenzo Nobile

    2016-07-01

    Full Text Available Background: Plant polyphenols have been found to be effective in preventing ultraviolet radiation (UVR-induced skin alterations. A dietary approach based of these compounds could be a safe and effective method to provide a continuous adjunctive photoprotection measure. In a previous study, a combination of rosemary (Rosmarinus officinalis and grapefruit (Citrus paradisi extracts has exhibited potential photoprotective effects both in skin cell model and in a human pilot trial. Objective: We investigated the efficacy of a combination of rosemary (R. officinalis and grapefruit (C. paradisi in decreasing the individual susceptibility to UVR exposure (redness and lipoperoxides and in improving skin wrinkledness and elasticity. Design: A randomised, parallel group study was carried out on 90 subjects. Furthermore, a pilot, randomised, crossover study was carried out on five subjects. Female subjects having skin phototype from I to III and showing mild to moderate chrono- or photoageing clinical signs were enrolled in both studies. Skin redness (a* value of CIELab colour space after UVB exposure to 1 minimal erythemal dose (MED was assessed in the pilot study, while MED, lipoperoxides (malondialdehyde skin content, wrinkle depth (image analysis, and skin elasticity (suction and elongation method were measured in the main study. Results: Treated subjects showed a decrease of the UVB- and UVA-induced skin alterations (decreased skin redness and lipoperoxides and an improvement of skin wrinkledness and elasticity. No differences were found between the 100 and 250 mg extracts doses, indicating a plateau effect starting from 100 mg extracts dose. Some of the positive effects were noted as short as 2 weeks of product consumption. Conclusions: The long-term oral intake of Nutroxsun™ can be considered to be a complementary nutrition strategy to avoid the negative effects of sun exposure. The putative mechanism for these effects is most likely to take place

  19. Aspects of the antimicrobial efficacy of grapefruit seed extract and its relation to preservative substances contained.

    Science.gov (United States)

    von Woedtke, T; Schlüter, B; Pflegel, P; Lindequist, U; Jülich, W D

    1999-06-01

    The antimicrobial efficacy as well as the content of preservative agents of six commercially available grapefruit seed extracts were examined. Five of the six extracts showed a high growth inhibiting activity against the test germs Bacillus subtilis SBUG 14, Micrococcus flavus SBUG 16, Staphylococcus aureus SBUG 11, Serratia marcescens SBUG 9, Escherichia coli SBUG 17, Proteus mirabilis SBUG 47, and Candida maltosa SBUG 700. In all of the antimicrobial active grapefruit seed extracts, the preservative benzethonium chloride was detected by thin layer chromatography. Additionally, three extracts contained the preserving substances triclosan and methyl parabene. In only one of the grapefruit seed extracts tested no preservative agent was found. However, with this extract as well as with several self-made extracts from seed and juiceless pulp of grapefruits (Citrus paradisi) no antimicrobial activity could be detected (standard serial broth dilution assay, agar diffusion test). Thus, it is concluded that the potent as well as nearly universal antimicrobial activity being attributed to grapefruit seed extract is merely due to the synthetic preservative agents contained within. Natural products with antimicrobial activity do not appear to be present.

  20. Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra-Performance Liquid Chromatography.

    Science.gov (United States)

    Vandermolen, Karen M; Cech, Nadja B; Paine, Mary F; Oberlies, Nicholas H

    2013-01-01

    Grapefruit juice can increase or decrease the systemic exposure of myriad oral medications, leading to untoward effects or reduced efficacy. Furanocoumarins in grapefruit juice have been established as inhibitors of cytochrome P450 3A (CYP3A)-mediated metabolism and P-glycoprotein (P-gp)-mediated efflux, while flavonoids have been implicated as inhibitors of organic anion transporting polypeptide (OATP)-mediated absorptive uptake in the intestine. The potential for drug interactions with a food product necessitates an understanding of the expected concentrations of a suite of structurally diverse and potentially bioactive compounds. Develop methods for the rapid quantitation of two furanocoumarins (bergamottin and 6',7'-dihydroxybergamottin) and four flavonoids (naringin, naringenin, narirutin and hesperidin) in five grapefruit juice products using ultra-performance liquid chromatography (UPLC). Grapefruit juice products were extracted with ethyl acetate; the concentrated extract was analysed by UPLC using acetonitrile:water gradients and a C18 -column. Analytes were detected using a photodiode array detector, set at 250 nm (furanocoumarins) and 310 nm (flavonoids). Intraday and interday precision and accuracy and limits of detection and quantitation were determined. Rapid (0.999. Considerable between-juice variation in the concentrations of these compounds was observed, and the quantities measured were in agreement with the concentrations published in HPLC studies. These analytical methods provide an expedient means to quantitate key furanocoumarins and flavonoids in grapefruit juice and other foods used in dietary substance-drug interaction studies. Copyright © 2013 John Wiley & Sons, Ltd.

  1. Changes in flavonoid content of grapefruit juice caused by thermal treatment and storage

    OpenAIRE

    Igual Ramo, Marta; García Martínez, Eva María; Camacho Vidal, Mª Mar; Martínez Navarrete, Nuria

    2011-01-01

    The effect of conventional and microwave pasteurization on the main flavonoids present in grapefruit juice and their stability throughout 2 months of refrigerated and frozen storage was evaluated. Individual flavonoids were analyzed by HPLC. The results showed that naringin, narirutin, quercetin and naringenin were the most abundant flavonoids in grapefruit juice. In general, although every pasteurization treatment caused a significant reduction in the content of all the studied flavonoids, t...

  2. Consumption of grapefruit is associated with higher nutrient intakes and diet quality among adults, and more favorable anthropometrics in women, NHANES 2003–2008

    Directory of Open Access Journals (Sweden)

    Mary M. Murphy

    2014-05-01

    Full Text Available Background: Dietary guidance recommends consumption of a nutrient-dense diet containing a variety of fruits. The purpose of this study was to estimate usual nutrient intakes and adequacy of nutrient intakes among adult grapefruit consumers and non-consumers, and to examine associations between grapefruit consumption and select health parameters. Methods: The analysis was conducted with data collected in the National Health and Nutrition Examination Survey (NHANES 2003–2008. Respondents reporting consumption of any amount of grapefruit or 100% grapefruit juice at least once during the 2 days of dietary recall were classified as grapefruit consumers. Results: Among adults aged 19+ years with 2 days of dietary recall (n=12,789, 2.5% of males and 2.7% of females reported consumption of 100% grapefruit juice or fresh, canned, or frozen grapefruit during the recalls. Grapefruit consumers were less likely to have usual intakes of vitamin C (males: 0% vs. 47%; females: 0% vs. 43%; P<0.001 and magnesium (P<0.05 below the estimated average requirement (EAR compared to non-consumers, and they were more likely to meet adequate intake levels for dietary fiber (P<0.05. Potassium and β-carotene intakes were significantly higher among grapefruit consumers (P<0.001. Diet quality as assessed by the Healthy Eating Index-2005 (HEI-2005 was higher in grapefruit consumers (males: 66.2 [95% CI: 61.0–71.5] vs. 55.4 [95% CI: 54.4–56.4]; females: 71.4 [95% CI: 65.1–77.6] vs. 61.2 [95% CI: 59.8–62.6]. Among women, grapefruit consumption was associated with lower body weight, waist circumference, body mass index (BMI, triglycerides, C-reactive protein (CRP, and higher high-density lipoprotein (HDL cholesterol (P<0.05, However, risk of being overweight/obese was not associated with grapefruit consumption. Conclusion: Consumption of grapefruit was associated with higher intakes of vitamin C, magnesium, potassium, dietary fiber, and improved diet quality

  3. Effects of grapefruit, grapefruit juice and water preloads on energy balance, weight loss, body composition, and cardiometabolic risk in free-living obese adults

    Directory of Open Access Journals (Sweden)

    Niswender Kevin D

    2011-02-01

    Full Text Available Abstract Background Reducing dietary energy density has proven to be an effective strategy to reduce energy intakes and promote weight control. This effect appears most robust when a low energy dense preload is consumed before meals. Yet, much discussion continues regarding the optimal form of a preload. The purpose of the present study was to compare effects of a solid (grapefruit, liquid (grapefruit juice and water preload consumed prior to breakfast, lunch and dinner in the context of caloric restriction. Methods Eighty-five obese adults (BMI 30-39.9 were randomly assigned to (127 g grapefruit (GF, grapefruit juice (GFJ or water preload for 12 weeks after completing a 2-week caloric restriction phase. Preloads were matched for weight, calories, water content, and energy density. Weekly measures included blood pressure, weight, anthropometry and 24-hour dietary intakes. Resting energy expenditure, body composition, physical performance and cardiometabolic risk biomarkers were assessed. Results The total amount (grams of food consumed did not change over time. Yet, after preloads were combined with caloric restriction, average dietary energy density and total energy intakes decreased by 20-29% from baseline values. Subjects experienced 7.1% weight loss overall, with significant decreases in percentage body, trunk, android and gynoid fat, as well as waist circumferences (-4.5 cm. However, differences were not statistically significant among groups. Nevertheless, the amount and direction of change in serum HDL-cholesterol levels in GF (+6.2% and GFJ (+8.2% preload groups was significantly greater than water preload group (-3.7%. Conclusions These data indicate that incorporating consumption of a low energy dense dietary preload in a caloric restricted diet is a highly effective weight loss strategy. But, the form of the preload did not have differential effects on energy balance, weight loss or body composition. It is notable that subjects in GF

  4. Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra Performance Liquid Chromatography

    Science.gov (United States)

    VanderMolen, Karen M.; Cech, Nadja B.; Paine, Mary F.

    2013-01-01

    Introduction Grapefruit juice can increase or decrease the systemic exposure of myriad oral medications, leading to untoward effects or reduced efficacy. Furanocoumarins in grapefruit juice have been established as inhibitors of cytochrome P450 3A (CYP3A)-mediated metabolism and P-glycoprotein (P-gp)-mediated efflux, while flavonoids have been implicated as inhibitors of organic anion transporting polypeptide (OATP)-mediated absorptive uptake in the intestine. The potential for drug interactions with a food product necessitates an understanding of the expected concentrations of a suite of structurally diverse and potentially bioactive compounds. Objective Develop methods for the rapid quantitation of two furanocoumarins (bergamottin and 6′,7′-dihydroxybergamottin) and four flavonoids (naringin, naringenin, narirutin, and hesperidin) in five grapefruit juice products using ultra performance liquid chromatography (UPLC). Methodology Grapefruit juice products were extracted with ethyl acetate; the concentrated extract was analyzed by UPLC using acetonitrile:water gradients and a C18 column. Analytes were detected using a photodiode array detector, set at 250 nm (furanocoumarins) and 310 nm (flavonoids). Intraday and interday precision and accuracy and limits of detection and quantitation were determined. Results Rapid (flavonoids. R2 values for the calibration curves of all analytes were >0.999. Considerable between-juice variation in the concentrations of these compounds was observed, and the quantities measured were in agreement with the concentrations published in HPLC studies. Conclusion These analytical methods provide an expedient means to quantitate key furanocoumarins and flavonoids in grapefruit juice and other foods used in dietary substance-drug interaction studies. PMID:23780830

  5. Characterization of the most odor-active volatiles in fresh, hand-squeezed juice of grapefruit (Citrus paradisi Macfayden).

    Science.gov (United States)

    Buettner, A; Schieberle, P

    1999-12-01

    By application of the aroma extract dilution analysis on an extract prepared from fresh grapefruit juice, 37 odor-active compounds were detected in the flavor dilution (FD) factor range of 4-256 and subsequently identified. Among them the highest odor activities (FD factors) were determined for ethyl butanoate, p-1-menthene-8-thiol, (Z)-3-hexenal, 4,5-epoxy-(E)-2-decenal, 4-mercapto-4-methylpentane-2-one, 1-heptene-3-one, and wine lactone. Besides the 5 last mentioned compounds, a total of 13 further odorants were identified for the first time as flavor constituents of grapefruit. The data confirmed results of the literature on the significant contribution of 1-p-menthene-8-thiol in grapefruit aroma but clearly showed that a certain number of further odorants are necessary to elicit the typical grapefruit flavor.

  6. Ocorrência do ácaro vermelho europeu Panonychus ulmi (Koch (Tetranychidae associado à cultura da videira no Rio Grande do Sul, Brasil European red spider mite Panonychus ulmi (Koch (Tetranychidae occurrence of vineyards in Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Noeli Juarez Ferla

    2008-09-01

    Full Text Available Neste artigo é descrita ocorrência e o dano causado pelo ácaro vermelho europeu Panonychus ulmi (Koch associado à cultura da videira. As coletas foram realizadas na safra 2005-2006 em Vitis vinifera L. da cultivar Merlot, nos municípios de Bento Gonçalves e Candiota, no Estado do Rio Grande do Sul, Brasil. As folhas infestadas apresentaram bronzeamento, com manchas avermelhadas na face adaxial, resultando na queda prematura das mesmas. Esse é o primeiro registro do ácaro vermelho europeu danificando a cultura da videira no Rio Grande do Sul.The occurrence and the damage caused for the European red spider mite Panonychus ulmi (Koch associated to the culture of the grapevine are described. The collections had been carried through in 2005-2006 seasons in Vitis vinifera L. of cultivating Merlot in Bento Gonçalves and Candiota counties, in the state of Rio Grande do Sul, Brazil. The infested leaves had presented bronzing, with spots redly in the adaxial face resulting in the premature fall. This is the first register of the European red mite damaging the culture of the grapevine in Rio Grande do Sul.

  7. Biosynthesis of Silver and Gold Crystals Using Grapefruit Extract

    Directory of Open Access Journals (Sweden)

    Chen Long

    2016-01-01

    crystals is discussed, indicating that the soluble biomolecules such as protein(s and vitamin C in grapefruit extract may play a crucial role in defining the morphology and/or crystal phase of silver and gold crystals.

  8. Grapefruit extract activity in the control of rose powdery mildew and black spot.

    Science.gov (United States)

    Wojdyła, A T

    2001-01-01

    Efficacy of grapefruit extract (a.i. of Biosept 33 SL) in the control of Sphaerotheca pannosa var. rosae and Diplocarpon rosae on roses was investigated during 1998-1999. The extract was applied as plant spray in concentrations from 0.017 to 0.099%. First treatment of rose shrubs was done when visible disease symptoms occurred on leaves and spraying was repeated 3 (in plastic tunnel) or 10-times (in the field) at weekly intervals. In the second experiment roses with visible powdery mildew symptoms were sprayed once with grapefruit extract. Leaves were sampled one or 7 days after the extract application and germination of spores of S. pannosa var. rosae on potato dextrose agar was evaluated. In the next experiment roses grown under plastic tunnel were sprayed once with the tested preparation. After 24 hours leaves were collected and appearance of fungal hyphae and spores of S. pannosa var. rosae was studied in scanning electron microscope. In the control of S. pannosa var. rosae grapefruit extract at conc. 0.066% was as effective as triforine (standard) applied at 0.027%. Reduction of concentration resulted in the decreased efficacy of the tested preparation. Spores of S. pannosa var. rosae collected one day after grapefruit extract application germinated in about 5%. Analyses of spore vitality 6 days letter showed that only about 15% of conidia could germinated on PDA agar. In contrary, spores from untreated leaves germinated in about 95%. Scanning electrone microscope analysis of leaves taken from plants protected with grapefruit extract showed that most of hyphae were separated from leaf surface. Almost all hyphae and spores were degenerated. In the control of D. rosae the preparation in all tested concentrations gave satisfactory results but was less effective than triforine.

  9. Anti-adhesion and antibiotic modulatory evaluation of grapefruit (Citrus paradisi juice and seed extract on bacteria isolated from urine and catheter

    Directory of Open Access Journals (Sweden)

    Michael Oluwole Osungunna

    2016-02-01

    Full Text Available Context: The in vivo use of grapefruit seed in the treatment of urinary tract infections (UTIs has been reported but the mechanism of action is yet to be explained. Aims: Evaluate the anti-adhesion and antibiotic modulatory activities of grapefruit seed extract and juice as their possible mechanisms of action. Methods: Sub-inhibitory concentrations of 2.5 and 5 mg/mL as well as 10.3 and 5.15 mg/mL of grapefruit seed extract and juice respectively were evaluated for modulatory activity of ciprofloxacin, streptomycin and nalidixic acid against one hundred and twenty seven bacterial isolates from mid-stream urine (MSU (100, catheter-stream urine (CSU (14 and catheter tips (CT (13 using the agar dilution method. Anti-adhesion activity of grapefruit seed extract and juice at sub-inhibitory concentrations of 2.5 and 1.03 mg/mL respectively was evaluated against twenty three (23 moderately adherent bacterial isolates from MSU (10, CSU (7 and CT (6 using the tissue culture plate method. Results: The results revealed that grapefruit juice (5.15 mg/mL showed more effect on nalidixic acid activity than seed extract (2.5 mg/mL. Grapefruit juice showed more anti-adhesion activity than grapefruit seed extract at the concentration tested. Conclusions: The study concluded that grapefruit seed extract and juice had anti-adhesion and antibiotic modulatory effects on bacteria associated with UTIs.

  10. Tracing phenolic compounds through manufacturing of edible films from orange and grapefruit peels

    OpenAIRE

    Hernández-Carrillo, J.G.; Valdez-Fragoso, A.; Welti-Chanes, J.; Mújica-Paz, H.

    2015-01-01

    Edible films naturally rich in phenolic compounds were prepared from orange and grapefruit peels. Free and total polyphenols were determined by Folin-Ciocalteau method and flavonoids were identified and quantified by HPLC in the manufacturing processes of films. Films from grapefruit and orange peel had 24.95 and 28.18 mg GAE/g (Gallic Acid Equivalents/g), respectively, retaining more than 50% of total phenolics from the raw material. Hesperidin (33.39 mg/g) was the main flavonoid in orange p...

  11. Amelioration of irradiation injury to Florida grapefruit by pretreatment with vapor heat or fungicides

    International Nuclear Information System (INIS)

    Miller, W.R.; McDonald, R.E.

    1998-01-01

    Grapefruit shipped to certain markets must be certified free of Caribbean fruit fly (Anastrepha suspensa Loew) (CFF) infestation. Low-dose irradiation is effective for the control of CFF by sterilization. This treatment is expected to be approved for industry usage in the near future. 'Marsh' grapefruit (Citrus paradisi Macf.) was treated with vapor heat (2 hours at 38 degrees C), and fungicidal treatments of thiabendazole (TBZ) (4 gm.L-1) and TBZ (1 gm.L-1) plus imazalil (1 gm.L-1) prior to irradiation at 0.5 or 1.0 kGy. Vapor heat reduced the severity and incidence of peel injury by approximately 50% without adversely affecting other quality attributes. The fungicide did not reduce peel injury. The use of vapor heat before low-dose irradiation quarantine treatment of grapefruit may ameliorate or eliminate peel injury caused by irradiation

  12. Postharvest quality of GA-treated Florida grapefruit after gamma irradiation with TBZ and storage

    International Nuclear Information System (INIS)

    Miller, W.R.; McDonald, R.E.

    1996-01-01

    Grapefruit, Citrus paradisi (Macf.), harvested from gibberellic acid (GA) treated trees were irradiated at 0.3 or 0.6 kGy, and evaluated for quality after treatment and simulated commercial storage. The peel of GA-treated fruit retained green color and the fruit were firmer than control fruit after treatment. A condition, not observed before with grapefruit, was described and termed ‘spongy fruit’, which increased as irradiation dosage increased. The incidence of fruit peel pitting after five weeks' storage increased from < 2% to 11% and 25% as irradiation dose increased from 0 to 0.3 and 0.6 kGy. The majority of pitting at 0.3 kGy was slight and would not have an affect on U.S. #1 Grade for grapefruit. Incidence of decay (mostly green mold) was reduced with thiabendazole (TBZ), and mean decay among all treatments was < 1%. Total soluble solids, titratable acidity and the resulting ratio was not affected by GA or irradiation. There was a general decline in the sensory preference for juice flavor, and pulp flavor and texture as irradiation dose increased. We conclude that GA-treated grapefruit will tolerate irradiation dosage of 0.3 kGy without serious damage; however, at dosage of 0.6 kGy, serious peel damage detrimental to fruit quality will likely develop during storage. (author)

  13. Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity.

    Science.gov (United States)

    Miyata, Masaaki; Takano, Hiroki; Guo, Lian Q; Nagata, Kiyoshi; Yamazoe, Yasushi

    2004-02-01

    Influence of grapefruit juice intake on aflatoxin B1 (AFB1)-induced liver DNA damage was examined using a Comet assay in F344 rats given 5 mg/kg AFB1 by gavage. Rats allowed free access to grapefruit juice for 5 days prior to AFB1 administration resulted in clearly reduced DNA damage in liver, to 65% of the level in rats that did not receive grapefruit juice. Furthermore, rats treated with grapefruit juice extract (100 mg/kg per os) for 5 days prior to AFB1 treatment also reduced the DNA damage to 74% of the level in rats that did not receive grapefruit juice. No significant differences in the portal blood and liver concentrations of AFB1 were observed between grapefruit juice intake rats and the controls. In an Ames assay with AFB1 using Salmonella typhimurium TA98, lower numbers of revertant colonies were detected with hepatic microsomes prepared from rats administered grapefruit juice, compared with those from control rats. Microsomal testosterone 6beta-hydroxylation was also lower with rats given grapefruit juice than with control rats. Immunoblot analyses showed a significant decrease in hepatic CYP3A content, but not CYP1A and CYP2C content, in microsomes of grapefruit juice-treated rats than in non-treated rats. No significant difference in hepatic glutathione S-transferase (GST) activity and glutathione content was observed in the two groups. GSTA5 protein was not detected in hepatic cytosol of the two groups. In microsomal systems, grapefruit juice extract inhibited AFB1-induced mutagenesis in the presence of a microsomal activation system from livers of humans as well as rats. These results suggest that grapefruit juice intake suppresses AFB1-induced liver DNA damage through inactivation of the metabolic activation potency for AFB1 in rat liver.

  14. [Effects of 33% grapefruit extract on the growth of the yeast--like fungi, dermatopytes and moulds].

    Science.gov (United States)

    Krajewska-Kułak, E; Lukaszuk, C; Niczyporuk, W

    2001-01-01

    Grapefruit seed extract was discovered by Jacob Harich an american immunologist in 1980. Assessment of the influence of grapefruit extract on the yeast-like fungi strains--Candida albicans growth. Material used in this investigation was ATCC test Candida albicans strains no 10231, 200 of Candida albicans strains, 5 of Candida sp. strains isolated from patients with candidiasis symptoms from different ontocenosis and 12 of dermatophytes and moulds isolated from patients. The susceptibility of the Candida was determined by serial dilution method. It seems that 33% grapefruit extract exert a potent antifungal activity against the yeast like fungi strains and had low activity against dermatophytes and moulds. Further studies in vitro and in vivo on greater number of the yeast-like fungi strains and other fungi species are needed.

  15. Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)

    Science.gov (United States)

    Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; Rivera, M.C.; Munoz, A.

    1998-01-01

    La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

  16. Effect of grapefruit juice or cimetidine coadministration on albendazole bioavailability

    NARCIS (Netherlands)

    Nagy, J.; Schipper, H. G.; Koopmans, R. P.; Butter, J. J.; van Boxtel, C. J.; Kager, P. A.

    2002-01-01

    The assumed metabolic breakdown of albendazole by mucosal CYP3A4 enzymes was studied by coadministering albendazole (10 mg/kg) with grapefruit juice. Concentrations of albendazole sulfoxide (ABZSX), the active metabolite of albendazole, were compared with those after albendazole was administered

  17. Comparative studies of cutins from lime (Citrus aurantifolia) and grapefruit (Citrus paradisi) after TFA hydrolysis.

    Science.gov (United States)

    Hernández Velasco, Brenda Liliana; Arrieta-Baez, Daniel; Cortez Sotelo, Pedro Iván; Méndez-Méndez, Juan Vicente; Berdeja Martínez, Blanca Margarita; Gómez-Patiño, Mayra Beatriz

    2017-12-01

    Grapefruit and lime cutins were analyzed and compared in order to obtain information about their cutin architecture. This was performed using a sequential hydrolysis, first with trifluoroacetic acid to remove most of the polysaccharides present in the cutins, followed by an alkaline hydrolysis in order to obtain the main aliphatic compounds. Analysis by CPMAS 13 C NMR and ATR FT-IR of the cutins after 2.0 M TFA revealed that grapefruit cutin has independent aliphatic and polysaccharide domains while in the lime cutin these components could be homogeneously distributed. These observations were in agreement with an AFM analysis of the cutins obtained in the hydrolysis reactions. The main aliphatic compounds were detected and characterized as 16-hydroxy-10-oxo-hexadecanoic acid and 10,16-dihydroxyhexadecanoic acid. These were present in grapefruit cutin at 35.80% and 21.86% and in lime cutin at 20.44% and 40.36% respectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Anti-adhesion and antibiotic modulatory evaluation of grapefruit (Citrus paradisi) juice and seed extract on bacteria isolated from urine and catheter

    OpenAIRE

    Michael Oluwole Osungunna; Grace O. Onawunmi

    2016-01-01

    Context: The in vivo use of grapefruit seed in the treatment of urinary tract infections (UTIs) has been reported but the mechanism of action is yet to be explained. Aims: Evaluate the anti-adhesion and antibiotic modulatory activities of grapefruit seed extract and juice as their possible mechanisms of action. Methods: Sub-inhibitory concentrations of 2.5 and 5 mg/mL as well as 10.3 and 5.15 mg/mL of grapefruit seed extract and juice respectively were evaluated for modulatory activit...

  19. Does a kampo medicine containing schisandra fruit affect pharmacokinetics of nifedipine like grapefruit juice?

    Science.gov (United States)

    Makino, Toshiaki; Mizuno, Fumika; Mizukami, Hajime

    2006-10-01

    Herb-drug interaction has attracted attention as medicinal topics recently. However, the drug information is sometimes confusing. Previous in vitro studies revealed that schisandra fruit had strong inhibitory effect on CYP3A4 and claimed the possibilities of its herb-drug interaction. In the present study, we evaluated the inhibitory effects of schisandra fruit and shoseiryuto, an herbal formula in Japanese traditional kampo medicine containing eight herbal medicines including schisandra fruit, on rat CYP3A activity in vitro, and the effect of shoseiryuto on pharmacokinetics of nifedipine in rats, in comparison with those of grapefruit juice, a well-characterized natural CYP3A inhibitor. Shoseiryuto and its herbal constituents, schisandra fruit, ephedra herb and cinnamon bark exhibited in vitro inhibitory effect of CYP3A. Although shoseiryuto inhibited rat CYP3A activity in vitro with a degree comparable to grapefruit juice, shoseiryuto did not significantly affect a plasma concentration profile of nifedipine in rats as grapefruit juice did. These results indicate that in vivo experiments using the extract of herbal medicine prepared with the same dosage form as patients take are necessary to provide proper information about herb-drug interaction.

  20. Presence of chemical additives and microbial inhibition capacity in grapefruit seed extracts used in apiculture.

    Science.gov (United States)

    Spinosi, Valerio; Semprini, Primula; Langella, Vincenzo; Scortichini, Giampiero; Calvarese, Silvano

    2007-01-01

    American foulbrood, caused by Paenibacillus larvae subsp. larvae (White 1906) is one of the most serious diseases of honey bees, causing beekeepers and health workers to make difficult, complex decisions and leading to the development of 'organic' treatments, such as grapefruit seed extract, with minor residue problems in the end product. This study evaluates the chemical composition of grapefruit seed extracts using gas chromatography/mass spectrometry for the detection of benzethonium chloride, cetrimonium bromide and decyltrimethylammonium chloride. The results obtained suggest a close correlation between the microbial effect and the presence of chemical additives in the samples analysed.

  1. Helichrysum and Grapefruit Extracts Boost Weight Loss in Overweight Rats Reducing Inflammation.

    Science.gov (United States)

    de la Garza, Ana Laura; Etxeberria, Usune; Haslberger, Alexander; Aumueller, Eva; Martínez, J Alfredo; Milagro, Fermín I

    2015-08-01

    Obesity is characterized by an increased production of inflammatory markers. High levels of circulating free fatty acids and chronic inflammation lead to increased oxidative stress, contributing to the development of insulin resistance (IR). Recent studies have focused on the potential use of flavonoids for obesity management due to their antioxidant and anti-inflammatory properties. This study was designed to investigate the antioxidant and anti-inflammatory effects of helichrysum and grapefruit extracts in overweight insulin-resistant rats. Thirty-eight male Wistar rats were randomly distributed in two groups: control group (n=8) and high-fat sucrose (HFS) group (n=30). After 22 days of ad libitum water and food access, the rats fed HFS diet changed to standard diet and were reassigned into three groups (n=10 each group): nonsupplemented, helichrysum extract (2 g/kg bw), and grapefruit extract (1 g/kg bw) administered for 5 weeks. Rats supplemented with both extracts gained less body weight during the 5-week period of treatment, showed lower serum insulin levels and liver TBARS levels. Leptin/adiponectin ratio, as an indicator of IR, was lower in both extract-administered groups. These results were accompanied by a reduction in TNFα gene expression in epididymal adipose tissue and intestinal mucosa, and TLR2 expression in intestinal mucosa. Helichrysum and grapefruit extracts might be used as complement hypocaloric diets in weight loss treatment. Both extracts helped to reduce weight gain, hyperinsulinemia, and IR, improved inflammation markers, and decreased the HFS diet-induced oxidative stress in insulin-resistant rats.

  2. Linfedema primário congênito em bovinos Red Angus Primary congenital lymphedema in Red Angus cattle

    Directory of Open Access Journals (Sweden)

    Juliana Targino S.A. Macêdo

    2009-09-01

    Full Text Available Casos de linfedema congênito foram observados acometendo 12 terneiros cruza Red Angus na região Central do Rio Grande do Sul. Os terneiros afetados apresentavam graus variáveis de edema subcutâneo ao nascimento, envolvendo principalmente os membros pélvicos, mas também outras regiões do corpo. A injeção de solução a 5% de azul de metileno no espaço interdigital dos membros pélvicos de três terneiros afetados e um controle, indicaram uma interrupção no fluxo da linfa, sugerindo uma falha dos linfáticos periféricos distais em contactar os troncos centrais. Na necropsia de três terneiros afetados, edema subcutâneo foi observado de modo variável nos membros pélvicos, prepúcio e abdômen ventral. Não foi observado edema nas cavidades orgânicas. Em dois casos, observou-se hipoplasia dos linfonodos poplíteos associadas à dilatação dos vasos linfáticos. Testes de DNA demonstraram que todos os terneiros afetados nasceram de vacas inseminadas pelo mesmo touro, sugerindo uma base genética para a doença. Levando em consideração que uma pequena porcentagem de terneiros nasceram de vacas inseminadas pelo touro suspeito, é provável que um modo autossômico recessivo esteja envolvido na hereditariedade da doença.Cases of congenital lymphedema were observed affecting 12 cross Red Angus calves from the central region of the state of Rio Grande do Sul, Brazil. Affected calves presented variable degrees of subcutaneous edema at birth, involving mainly the hind limbs but also other body regions. The injection of methylene blue dye in 5% solution into the interdigital space of the hind limbs of three affected calves and one normal control indicated an interruption of the lymph flow in the affected calves; this suggests a failure of the distal peripheral lymphatics to connect with the central trunks. At necropsy of three affected calves subcutaneous edema was variably observed in the hind limbs, prepuce and ventral abdomen. Edema

  3. [Survey of synthetic disinfectants in grapefruit seed extract and its compounded products].

    Science.gov (United States)

    Sugimoto, Naoki; Tada, Atsuko; Kuroyanagi, Masanori; Yoneda, Yuko; Yun, Young Sook; Kunugi, Akira; Sato, Kyoko; Yamazaki, Takeshi; Tanamoto, Ken-Ichi

    2008-02-01

    Grapefruit seed extract (GSE), derived from the seeds of grapefruit (Citrus paradisi MCAF.), is listed as a natural food additive in Japan. Products containing GSE are used as disinfectants made from only natural sources, especially after Japanese researchers found that GSE prevents the growth of norovirus. On the other hand, recent overseas studies indicated that synthetic disinfectants, such as benzalkonium and benzethonium chlorides, were present in some commercial GSE products. To confirm the quality of commercial GSE products available in Japanese markets, we carried out comprehensive research to identify the major constituents of commercial GSE products which are used as food additives (13 products from 6 manufacturers), dietary supplements (5 products from 4 manufacturers), cosmetic materials (16 products from 10 manufacturers) and disinfectant or deodorant sprays (7 products from 7 manufacturers). By means of NMR and LC/MS analysis, synthetic disinfectants such as benzethonium or benzalkonium salts were detected in most of the commercial GSE products.

  4. Botanical insecticides in controlling Kelly's citrus thrips (Thysanoptera: Thripidae) on organic grapefruits.

    Science.gov (United States)

    Vassiliou, V A

    2011-12-01

    Kelly's citrus thrips, Pezothrips kellyanus (Bagnall) (Thysanoptera: Thripidae) was first recorded in Cyprus in 1996 and became an economic citrus pest. In Cyprus, Kelly's citrus thrips larvae cause feeding damage mainly on immature lemon and grapefruit fruits. Use of botanical insecticides is considered an alternative tool compared with synthetic chemicals, in offering solutions for healthy and sustainable citrus production. During 2008-2010, the efficacy of the botanical insecticides azadirachtin (Neemex 0.3%W/W and Oikos 10 EC), garlic extract (Alsa), and pyrethrins (Vioryl 5%SC) was evaluated in field trials against Kelly's citrus thrips larval stage I and II aiming at controlling the pest's population and damage to organic grapefruit fruits. In each of the trial years treatments with pyrethrins and azadirachtin (Neemex 0.3%W/W) were the most effective against Kelly's citrus thrips compared with the untreated control (for 2008: P extract showed the lowest effect from all the botanicals used compared with the untreated control.

  5. Gamma irradiation followed by cold storage as a quarantine treatment for Florida grapefruit infested with Caribbean fruit fly

    International Nuclear Information System (INIS)

    Von Windeguth, D.L.; Gould, W.P.

    1990-01-01

    'Marsh' white grapefruit, Citrus paradisi (Macf.). infested with eggs and larvae of Caribbean fruit fly, Anastrepha suspensa (Loew) were subjected to ionizing radiation at several low doses followed by cold (1.1°C) storage for 0 to 8 days. Data analyses indicated that an irradiation dose of 50 Gray followed by 5 days of cold storage will give in excess of probit 9 level of quarantine security. A test involving more than 100,000 insects infesting grapefruit confirmed the efficacy of this treatment

  6. Hypocholesterolemic properties of grapefruit (Citrus paradisii and shaddock (Citrus maxima juices and inhibition of angiotensin-1-converting enzyme activity

    Directory of Open Access Journals (Sweden)

    Ganiyu Oboh

    2014-12-01

    Full Text Available Grapefruit (Citrus paradisii and shaddock (Citrus maxima juices are used in folk medicine for the management of hypertension and other cardiovascular diseases, but the mechanism of action by which they exert their therapeutic action is unclear. The aim of this study was to investigate the effect of grapefruit and shaddock juices on angiotensin-1-converting enzyme (ACE activity in vitro and the hypocholesterolemic properties of the juices in rats fed a high-cholesterol diet. Grapefruit juice had higher total phenol and flavonoid contents than shaddock juice, while both juices inhibited ACE activity in a dose-dependent manner. Furthermore, administration of the juices to rats fed a high-cholesterol diet caused a significant reduction in plasma total cholesterol, triglyceride, and low-density lipoprotein–cholesterol levels and an increase in high-density lipoprotein–cholesterol levels. The inhibition of ACE activity in vitro and in vivo hypocholesterolemic effect of the juices could explain the use of the juices in the management of cardiovascular diseases.

  7. Somatic hybridization in Citrus: navel orange (C. sinensis Osb.) and grapefruit (C. paradisi Macf.).

    Science.gov (United States)

    Ohgawara, T; Kobayashi, S; Ishii, S; Yoshinaga, K; Oiyama, I

    1989-11-01

    Protoplasts of navel orange, isolated from embryogenic nucellar cell suspension culture, were fused with protoplasts of grapefruit isolated from leaf tissue. The fusion products were cultured in the hormone-free medium containing 0.6 M sucrose. Under the culture conditions, somatic embryogenesis of navel orange protoplasts was suppressed, while cell division of grapefruit mesophyll protoplasts was not induced. Six embryoids were obtained and three lines regenerated to complete plants through embryogenesis. Two of the regenerated lines exhibited intermediate morphological characteristics of the parents in the leaf shape. Chromosome counts showed that these regenerated plants had expected 36 chromosomes (2n=2x=18 for each parent). The rDNA analysis using biotin-labeled rRNA probes confirmed the presence of genomes from both parents in these plants. This somatic hybridization system would be useful for the practical Citrus breeding.

  8. Volatile constituents of redblush grapefruit (Citrus paradisi) and pummelo (Citrus grandis) peel essential oils from Kenya.

    Science.gov (United States)

    Njoroge, Simon Muhoho; Koaze, Hiroshi; Karanja, Paul Nyota; Sawamura, Masayoshi

    2005-12-14

    The volatile constituents of cold-pressed peel essential oils of redblush grapefruit (Citrus paradisi Macfadyen forma Redblush) and pummelo (Citrus grandis Osbeck) from the same locality in Kenya were determined by GC and GC-MS. A total of 67 and 52 compounds, amounting to 97.9 and 98.8% of the two oils, respectively, were identified. Monoterpene hydrocarbons constituted 93.3 and 97.5% in the oils, respectively, with limonene (91.1 and 94.8%), alpha-terpinene (1.3 and 1.8%), and alpha-pinene (0.5%) as the main compounds. Sesquiterpene hydrocarbons constituted 0.4% in each oil. The notable compounds were beta-caryophyllene, alpha-cubebene, and (E,E)-alpha-farnesene. Oxygenated compounds constituted 4.2 and 2.0% of the redblush grapefruit and pummelo oils, respectively, out of which carbonyl compounds (2.0 and 1.3%), alcohols (1.4 and 0.3%), and esters (0.7 and 0.4%) were the major groups. Heptyl acetate, octanal, decanal, citronellal, and (Z)-carvone were the main constituents (0.1-0.5%). Perillene, (E)-carveol, and perillyl acetate occurred in the redblush grapefruit but were absent from the pummelo oil. Nootkatone, alpha- and beta-sinensal, methyl-N-methylanthranilate, and (Z,E)-farnesol were prominent in both oils.

  9. 7 CFR 944.350 - Safeguard procedures for avocados, grapefruit, kiwifruit, olives, oranges, prune variety plums...

    Science.gov (United States)

    2010-01-01

    ... plums (fresh prunes), and table grapes for processing; (3) Olives for processing into oil; (4) Grapefruit for animal feed; or (5) Avocados for seed shall obtain an “Importer's Exempt Commodity Form” (FV-6...

  10. Improvement of the half-embryo test for detection of gamma-irradiated grapefruit and its application to irradiated oranges and lemons

    International Nuclear Information System (INIS)

    Kawamura, Y.; Uchiyama, S.; Saito, Y.

    1989-01-01

    The duration of the half-embryo test used for identification of gamma-irradiated grapefruit was shortened by increasing germination temperature to 35 degrees C. Maximum shooting percentages were reached within 3 days. Gibberellin application reduced the required incubation time to 2 days. Half-embryos extracted from irradiated orange and lemon gave similar results to those of grapefruit. This half-embryo test is proposed as an identification method for irradiated citrus. Assessment can be made after 3 to 4 days when shooting percentage is greater than 50%

  11. Modulation of hyperglycemia and TNFα-mediated inflammation by helichrysum and grapefruit extracts in diabetic db/db mice.

    Science.gov (United States)

    de la Garza, Ana Laura; Etxeberria, Usune; Palacios-Ortega, Sara; Haslberger, Alexander G; Aumueller, Eva; Milagro, Fermín I; Martínez, J Alfredo

    2014-09-01

    Type-2 diabetes is associated with a chronic low-grade systemic inflammation accompanied by an increased production of adipokines/cytokines by obese adipose tissue. The search for new antidiabetic drugs with different mechanisms of action, such as insulin sensitizers, insulin secretagogues and α-glucosidase inhibitors, has directed the focus on the potential use of flavonoids in the management of type-2 diabetes. Thirty six diabetic male C57BL/6J db/db mice were fed a standard diet and randomly assigned into four experimental groups: non-treated control, (n = 8); acarbose (5 mg per kg bw, n = 8); helichrysum (1 g per kg bw, n = 10) and grapefruit (0.5 g per kg bw, n = 10) for 6 weeks. The mRNA expression in pancreas, liver and epididymal adipose tissue was determined by RT-PCR. DNA methylation was quantified in epididymal fat using pyrosequencing. Mice supplemented with helichrysum and grapefruit extracts showed a significant decrease in fasting glucose levels (p helichrysum and grapefruit extracts improved hyperglycemia through the regulation of glucose metabolism in the liver and reduction of the expression of proinflammatory genes in the liver and visceral fat. The hypermethylation of TNFα in adipose tissue may contribute to reduce the inflammation associated with diabetes and obesity.

  12. Highly efficient production of nootkatone, the grapefruit aroma from valencene, by biotransformation.

    Science.gov (United States)

    Furusawa, Mai; Hashimoto, Toshihiro; Noma, Yoshiaki; Asakawa, Yoshinori

    2005-11-01

    Nootkatone, the most important and expensive aromatic of grapefruit, decreases the somatic fat ratio, and thus its demand is increasing in the cosmetic and fiber sectors. A sesquiterpene hydrocarbon, (+)-valencene, which is cheaply obtained from Valencia orange, was biotransformed by the green algae Chlorella species and fungi such as Mucor species, Botryosphaeria dothidea, and Botryodiplodia theobromae to afford nootkatone in high yield.

  13. Effect of ethylene on naringin, narirutin and nootkatone accumulation in grapefruit.

    Science.gov (United States)

    Puig, D G; Pérez, M L; Fuster, M D; Ortuño, A; Sabater, F; Porras, I; Lidón, A G; Del Río, J A

    1995-06-01

    This paper studies the effect of different concentrations of ethephon on the levels of the sesquiterpene, nootkatone, and of the flavanones, naringin and narirutin, in grapefruit fruits. The results show that nootkatone synthesis and/or accumulation was stimulated by all the concentrations of ethephon assayed, while the levels of naringin and narirutin in the rind diminished. These results open up new perspectives concerning the possible regulation of the secondary metabolism of the plants.

  14. Apple scab control with grapefruit seed extract: no alternative to chemical fungicides

    OpenAIRE

    Spitaler, Renate; Marschall, Klaus; Zidorn, Christian; Kelderer, Markus; Zelger, Roland; Stuppner, Hermann

    2004-01-01

    The growth inhibiting effect of four commercially available grapefruit seed extracts on the causal organism of apple scab Venturia inaequalis was tested. Germination of the conidia of Venturia inaequalis was pronouncedly inhibited by all tested extracts. The commercial products were analyzed by high pressure liquid chromatography and thin layer chromatography. All samples contained at least one preserving agent. These substances were identified as either benzethonium chloride,...

  15. In Vitro Studies on Phytochemical Content, Antioxidant, Anticancer, Immunomodulatory, and Antigenotoxic Activities of Lemon, Grapefruit, and Mandarin Citrus Peels.

    Science.gov (United States)

    Diab, Kawthar Ae

    2016-01-01

    In recent years, there has been considerable research on recycling of agroindustrial waste for production of bioactive compounds. The food processing industry produces large amounts of citrus peels that may be an inexpensive source of useful agents. The present work aimed to explore the phytochemical content, antioxidant, anticancer, antiproliferation, and antigenotxic activities of lemon, grapefruit, and mandarin peels. Peels were extracted using 98% ethanol and the three crude extracts were assessed for their total polyphenol content (TPC), total flavonoid content (TFC), and antioxidant activity using DPPH (1, 1diphenyl2picrylhydrazyl). Their cytotoxic and mitogenic proliferation activities were also studied in human leukemia HL60 cells and mouse splenocytes by CCK8 assay. In addition, genotoxic/ antigenotoxic activity was explored in mouse splenocytes using chromosomal aberrations (CAs) assay. Lemon peels had the highest of TPC followed by grapefruit and mandarin. In contrast, mandarin peels contained the highest of TFC followed by lemon and grapefruit peels. Among the extracts, lemon peel possessed the strongest antioxidant activity as indicated by the highest DPPH radical scavenging, the lowest effective concentration 50% (EC50= 42.97 ?g extract/ mL), and the highest Trolox equivalent antioxidant capacity (TEAC=0.157). Mandarin peel exhibited moderate cytotoxic activity (IC50 = 77.8 ?g/mL) against HL60 cells, whereas grapefruit and lemon peels were ineffective antileukemia. Further, citrus peels possessed immunostimulation activity via augmentation of proliferation of mouse splenocytes (Tlymphocytes). Citrus extracts exerted noncytotoxic, and antigenotoxic activities through remarkable reduction of CAs induced by cisplatin in mouse splenocytes for 24 h. The phytochemical constituents of the citrus peels may exert biological activities including anticancer, immunostimulation and antigenotoxic potential.

  16. The Influence of Different Interstock Lengths of Minneola Tanjelo on Photosynthetic Parameters and Fruit Yield of Star Ruby Grapefruit

    Directory of Open Access Journals (Sweden)

    Bilge Yılmaz

    2014-05-01

    Full Text Available In this study, Minneola Tangelo hybrid, a cross of grapefruit and mandarin (Duncan grapefruit x Dancy mandarin, used as interstock to Star Ruby grapefruit with different lengths. Effects of different interstock lengths on fruit yield and quality, plant development and photosynthetic parameters were investigated. According to the results, different interstock lengths significantly affected fruit yield and size. The highest fruit yield was determined in T-M20-S whereas the lowest was on T-M5-S. The highest fruit size were determined in Star Ruby fruits on T-M5-S and T-M40-S whereas the lowest on T-M20-S and T-S (control. T-M40-S and T-M20-S treatments markedly reduced stem diameter and tree canopy in comparison to other treatments and control. Usage of different interstock lengths did not significantly affected some of fruit quality traits, net photosynthetic rate, stomatal conductance, leaf transpiration rate, leaf water usage efficiency and leaf chlorophyll concentration. In regards to seasonal changes, net photosynthetic rate were higher in spring and summer seasons then winter and fall seasons.

  17. Properties of a polygalacturonase-inhibiting protein isolated from 'Oroblanco' grapefruit.

    Science.gov (United States)

    D'hallewin, Guy; Schirra, Mario; Powell, Ann L. T.; Greve, L. Carl; Labavitch, John M.

    2004-03-01

    Polygalacturonase inhibiting protein (PGIP) was extracted from 'Oroblanco' grapefruit type (triploid pummelo-grapefruit) albedo tissue, purified and partially characterized. Extraction was carried out at 4 degrees C with a high ionic strength extraction buffer. After dialysis and concentration by ultrafiltration the extract was chromatographed on concanavalin A-Sepharose. The PGIP activity was bound by the lectin and then eluted using 250 mM alpha-methyl mannopyranoside, resulting in a 17-fold purification of the PGIP and demonstrating its glycoprotein nature. The anion-exchange and size-exclusion chromatography steps that followed gave a PGIP that was 857-fold purified relative to the initial tissue extract, and having a 44 kDa molecular weight, as estimated by SDS-PAGE electrophoresis. PGIP inhibition activity was tested with endo-polygalacturonase (EC 3.2.1.15) produced by Penicillium italicum and Botrytis cinerea. The radial diffusion and reducing sugar assays showed that P. italicum and B. cinerea endo-PGs were affected by PGIP, whereas no endo-PG activity was detected in the culture filtrate of P. digitatum. In vitro tests revealed that PGIP inhibited P. italicum and B. cinerea growth. By contrast, the influence of PGIP on P. digitatum, growth was negligible, perhaps because this fungus does not produce endo-PG. Following heating for 10 min at 65 degrees C the inhibitory activity of PGIP was reduced by 43%. PGIP activity decreased further as heating temperature increased, and was completely suppressed after heating at 100 degrees C for 10 min.

  18. Postharvest storage quality of grapefruit placed in polyethylene bags with or without micro-perforation

    Science.gov (United States)

    Washed ‘Marsh’ white grapefruit were placed in polyethylene (PE) bags (1 mil) with or without micro-perforation holes (representing 0.002% of the bag surface) and evaluated for juice quality, firmness, and the development of decay and disorders during storage for 30, 60, or 90 days at 50oF. Each tre...

  19. The effect of 'Candidatus Liberibacter asiaticus' infection on the proteomic profiles and nutritional status of pre-symptomatic and symptomatic grapefruit (Citrus paradisi) plants.

    Science.gov (United States)

    Nwugo, Chika C; Lin, Hong; Duan, Yongping; Civerolo, Edwin L

    2013-04-11

    Huanglongbing (HLB) is a highly destructive citrus disease which threatens citrus production worldwide and 'Candidatus Liberibacter asiaticus' (Las), a non-culturable phloem-limited bacterium, is an associated causal agent of the disease. To better understand the physiological and molecular processes involved in host responses to Las, 2-DE and mass spectrometry analyses, as well as ICP spectroscopy analysis were employed to elucidate the global protein expression profiles and nutrient concentrations in leaves of Las-infected grapefruit plants at pre-symptomatic or symptomatic stages for HLB. This study identified 123 protein spots out of 191 spots that showed significant changes in the leaves of grapefruit plants in response to Las infection and all identified spots matched to 69 unique proteins/peptides. A down-regulation of 56 proteins including those associated with photosynthesis, protein synthesis, and metabolism was correlated with significant reductions in the concentrations of Ca, Mg, Fe, Zn, Mn, and Cu in leaves of grapefruit plants in response to Las infection, particularly in symptomatic plants. Oxygen-evolving enhancer (OEE) proteins, a PSI 9 kDa protein, and a Btf3-like protein were among a small group of proteins that were down-regulated in both pre-symptomatic and symptomatic plants in response to Las infection. Furthermore, a Las-mediated up-regulation of 13 grapefruit proteins was detected, which included Cu/Zn superoxide dismutase, chitinases, lectin-related proteins, miraculin-like proteins, peroxiredoxins and a CAP 160 protein. Interestingly, a Las-mediated up-regulation of granule-bound starch synthase was correlated with an increase in the K concentrations of pre-symptomatic and symptomatic plants. This study constitutes the first attempt to characterize the interrelationships between protein expression and nutritional status of Las-infected pre-symptomatic or symptomatic grapefruit plants and sheds light on the physiological and molecular

  20. The anti-biofilm activity of lemongrass (Cymbopogon flexuosus) and grapefruit (Citrus paradisi) essential oils against five strains of Staphylococcus aureus.

    Science.gov (United States)

    Adukwu, E C; Allen, S C H; Phillips, C A

    2012-11-01

    To determine the sensitivity of five strains of Staphylococcus aureus to five essential oils (EOs) and to investigate the anti-biofilm activity of lemongrass and grapefruit EOs. Antimicrobial susceptibility screening was carried out using the disk diffusion method. All of the strains tested were susceptible to lemongrass, grapefruit, bergamot and lime EOs with zones of inhibition varying from 2·85 to 8·60 cm although they were resistant to lemon EO. Lemongrass EO inhibited biofilm formation at 0·125% (v/v) as measured by colorimetric assay and at 0·25% (v/v) no metabolic activity was observed as determined by 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction. Grapefruit EO did not show any anti-biofilm activity. Following exposure to lemongrass EO extensive disruption to Staph. aureus biofilms was shown under scanning electron microscopy. In comparison to the other EOs tested, lemongrass exhibited the most effective antimicrobial and anti-biofilm activity. The effect of lemongrass EO highlights its potential against antibiotic resistant Staph. aureus in the healthcare environment. © 2012 The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology.

  1. Use of nootkatone as a senescence indicator for Rouge La Toma Cv. grapefruit (Citrus paradisi Macf.).

    Science.gov (United States)

    Biolatto, Andrea; Sancho, Ana M; Cantet, Rodolfo J C; Güemes, Daniel R; Pensel, Norma A

    2002-08-14

    The objective of this research was to study the usefulness of nootkatone as a senescence indicator for Rouge La Toma cv. grapefruit (Citrus paradisi Macf.), simulating different treatments that included the normal postharvest handling of citrus fruits: temperature conditioning, cold storage, shipment periods to overseas markets such as Japan and the U.S., marketing conditions, and storage at nonchilling temperature (control treatments). The highest nootkatone levels, determined by GLC-MS analyses, were detected in fruits subjected to control treatments. No significant differences were observed in nootkatone levels between treatments either with or without temperature conditioning prior to the start of the cold storage. Levels of nootkatone increased throughout time for all assayed treatments. The linear regressions of nootkatone levels showed correlation coefficients of 0.80 and 0.83 with storage time (29 and 42 days, respectively). Therefore, nootkatone appears to be a good indicator of senescence for Rouge La Toma grapefruit.

  2. Effect of grapefruit juice and food on the pharmacokinetics of pirfenidone in healthy Chinese volunteers: a diet-drug interaction study.

    Science.gov (United States)

    Hu, Jinqing; Shang, Dewei; Xu, Xinwen; He, Xiuling; Ni, Xiaojia; Zhang, Ming; Wang, Zhanzhang; Qiu, Chang; Deng, Shuhua; Lu, Haoyang; Zhu, Xiuqing; Huang, Wencan; Wen, Yuguan

    2016-01-01

    1. Ingestion of grapefruit juice and food could be factors affecting the pharmacokinetics of pirfenidone, a promising drug for treatment of idiopathic pulmonary fibrosis. 2. A randomized, open-label, three-period crossover study was carried out in 12 healthy Chinese male volunteers who were randomized to one of the three treatments: pirfenidone tablets (0.4 g) were orally administered to fasted or fed subjects, or with grapefruit juice. The washout period was 7 d. 3. Significantly reduced maximum plasma concentration (Cmax, 5.0 5 ± 1.39 versus 10.9 0 ± 2.94 mg·L(- 1)), modestly affected area-under-the-plasma concentration-time curve (AUC) from time zero to 12 h post dosing (AUC0-12 h, 21.8 9 ± 6.47 versus 26.1 6 ± 7.32 mg·h·L(- 1)) and delayed time to reach Cmax (Tmax) were observed in fed group compared with fasted group. Similar effects on Cmax (5.8 2 ± 1.23 versus 10.9 0 ± 2.94 mg·L(- 1)) and AUC0-12 h (modest but not statistically significant, 24.4 4 ± 7.40 versus 26.1 6 ± 7.32 mg·h·L(- 1)) were observed for grapefruit juice compared to fasted subjects. 4. Co-administration of pirfenidone with grapefruit juice resulted in modestly reduced overall oral absorption and significantly reduced peak concentrations compared to fasting, which was similar to effect of food ingestion. No adverse events were observed in the study, but relatively dramatic reduction of peak concentrations should raise concerns for clinical efficacy and safety.

  3. Liquid Chromatography-Electrospray Ionization Mass Spectrometry Analysis of Limonoids and Flavonoids in Seeds of Grapefruits, Other Citrus Species, and Dietary Supplements.

    Science.gov (United States)

    Avula, Bharathi; Sagi, Satyanarayanaraju; Wang, Yan-Hong; Wang, Mei; Gafner, Stefan; Manthey, John A; Khan, Ikhlas A

    2016-07-01

    A selective UHPLC-DAD-QToF-MS method was developed to screen grapefruit seeds, and the seeds of other Citrus species for limonoid aglycones, acids, glucosides, and flavonoids. These classes of compounds were identified in positive and negative ion modes over a mass-to-charge range from 100-1500. Accurate mass values, elution times, and fragmentation patterns obtained by QToF-mass spectrometry were used to identify or tentatively characterize the compounds detected in the sample of this study. Limonin was the major limonoid in most of the seeds of Citrus species, followed by nomilin. This analytical method was successfully applied for the analysis of commercial extracts and dietary supplements claiming to contain grapefruit seed extract, or extracts made from the seed and other fruit parts such as the peel or pulp. Many commercial products contained large numbers of flavonoids, indicating the use of peel, pulp, or seed coat. This method also permitted detection of synthetic preservatives such as benzethonium chloride, methylparaben, and triclosan in commercial grapefruit seed extract products. Out of the 17 commercial products analyzed, two contained the synthetic antimicrobial agent benzethonium chloride. Georg Thieme Verlag KG Stuttgart · New York.

  4. Antimicrobial activity of grapefruit seed and pulp ethanolic extract.

    Science.gov (United States)

    Cvetnić, Zdenka; Vladimir-Knezević, Sanda

    2004-09-01

    Antibacterial and antifungal activity of ethanolic extract of grapefruit (Citrus paradisi Macf., Rutaceae) seed and pulp was examined against 20 bacterial and 10 yeast strains. The level of antimicrobial effects was established using an in vitro agar assay and standard broth dilution susceptibility test. The contents of 3.92% of total polyphenols and 0.11% of flavonoids were determined spectrometrically in crude ethanolic extract. The presence of flavanones naringin and hesperidin in the extract was confirmed by TLC analysis. Ethanolic extract exibited the strongest antimicrobial effect against Salmonella enteritidis (MIC 2.06%, m/V). Other tested bacteria and yeasts were sensitive to extract concentrations ranging from 4.13% to 16.50% (m/V).

  5. Functional chitosan-based grapefruit seed extract composite films for applications in food packaging technology

    International Nuclear Information System (INIS)

    Tan, Y.M.; Lim, S.H.; Tay, B.Y.; Lee, M.W.; Thian, E.S.

    2015-01-01

    Highlights: • Chitosan-based grapefruit seed extract (GFSE) films were solution casted. • GFSE was uniformly dispersed within all chitosan film matrices. • All chitosan-based composite films showed remarkable transparency. • Increasing amounts of GFSE incorporated increased the elongation at break of films. • Chitosan-based GFSE composite films inhibited the proliferation of fungal growth. - Abstract: Chitosan-based composite films with different amounts of grapefruit seed extract (GFSE) (0.5, 1.0 and 1.5% v/v) were fabricated via solution casting technique. Experimental results showed that GFSE was uniformly dispersed within all chitosan film matrices. The presence of GFSE made the films more amorphous and tensile strength decreased, while elongation at break values increased as GFSE content increased. Results from the measurement of light transmission revealed that increasing amounts of GFSE (from 0.5 to 1.5% v/v) did not affect transparency of the films. Furthermore, packaging of bread samples with chitosan-based GFSE composite films inhibited the proliferation of fungal growth as compared to control samples. Hence, chitosan-based GFSE composite films have the potential to be a useful material in the area of food technology

  6. Functional chitosan-based grapefruit seed extract composite films for applications in food packaging technology

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Y.M. [Department of Mechanical Engineering, National University of Singapore (Singapore); Lim, S.H.; Tay, B.Y. [Forming Technology Group, Singapore Institute of Manufacturing Technology (Singapore); Lee, M.W. [Food Innovation and Resource Centre, Singapore Polytechnic (Singapore); Thian, E.S., E-mail: mpetes@nus.edu.sg [Department of Mechanical Engineering, National University of Singapore (Singapore)

    2015-09-15

    Highlights: • Chitosan-based grapefruit seed extract (GFSE) films were solution casted. • GFSE was uniformly dispersed within all chitosan film matrices. • All chitosan-based composite films showed remarkable transparency. • Increasing amounts of GFSE incorporated increased the elongation at break of films. • Chitosan-based GFSE composite films inhibited the proliferation of fungal growth. - Abstract: Chitosan-based composite films with different amounts of grapefruit seed extract (GFSE) (0.5, 1.0 and 1.5% v/v) were fabricated via solution casting technique. Experimental results showed that GFSE was uniformly dispersed within all chitosan film matrices. The presence of GFSE made the films more amorphous and tensile strength decreased, while elongation at break values increased as GFSE content increased. Results from the measurement of light transmission revealed that increasing amounts of GFSE (from 0.5 to 1.5% v/v) did not affect transparency of the films. Furthermore, packaging of bread samples with chitosan-based GFSE composite films inhibited the proliferation of fungal growth as compared to control samples. Hence, chitosan-based GFSE composite films have the potential to be a useful material in the area of food technology.

  7. Combined osmodehydration and high pressure processing on the enzyme stability and antioxidant capacity of a grapefruit jam

    Science.gov (United States)

    A combined osmodehydration process and high pressure treatment (OD-HHP) was developed for grapefruit jam preservation. The inactivation kinetics of pectinmethylesterase (PME) and peroxidase (POD) in the osmodehydrated (OD) jam treated by combined thermal (45-75°C) and high pressure (550–700 MPa) pro...

  8. Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways

    OpenAIRE

    Brzozowski, Tomasz; Konturek, Peter C; Drozdowicz, Danuta; Konturek, Stanislaw J; Zayachivska, Oxana; Pajdo, Robert; Kwiecien, Slawomir; Pawlik, Wieslaw W; Hahn, Eckhart G

    2005-01-01

    AIM: Grapefruit-seed extract (GSE) containing flavonoids, possesses antibacterial and antioxidative properties but whether it influences the gastric defense mechanism and gastroprotection against ethanol- and stress-induced gastric lesions remains unknown.

  9. Does dietary inulin affect biological activity of a grapefruit flavonoid-rich extract?

    OpenAIRE

    Jurgoński, Adam; Juśkiewicz, Jerzy; Kowalska, Karolina; Zduńczyk, Zenon

    2012-01-01

    Abstract Background The aim of the study was to verify that the concomitant presence of grapefruit flavonoid extract with inulin in a Western-type diet may provide synergistic effects to the hindgut metabolism, as well as blood lipid and mineral profiles. Methods Forty male Wistar rats were distributed into 4 groups and fed for 28 days with diets rich in fat, cholesterol and protein. A two-way repeated measures ANOVA was applied to assess the effects of inulin (v. sucrose, 5% of the diet), th...

  10. Coffee inhibition of CYP3A4 in vitro was not translated to a grapefruit-like pharmacokinetic interaction clinically.

    Science.gov (United States)

    Dresser, George K; Urquhart, Brad L; Proniuk, Julianne; Tieu, Alvin; Freeman, David J; Arnold, John Malcolm; Bailey, David G

    2017-10-01

    Grapefruit can augment oral medication bioavailability through irreversible (mechanism-based) inhibition of intestinal CYP3A4. Supplementary data from our recent coffee-drug interaction clinical study showed some subjects had higher area under the plasma drug concentration - time curve (AUC) and plasma peak drug concentration (Cmax) of the CYP3A4 probe felodipine compared to aqueous control. It was hypothesized that coffee might interact like grapefruit in responsive individuals. Beans from six geographical locations were consistently brewed into coffee that was separated chromatographically to a methanolic fraction for in vitro inhibition testing of CYP3A4 metabolism of felodipine at 1% coffee strength. The effect of simultaneous incubation and 10-min preincubation with coffee fractions determined whether coffee had direct and mechanism-based inhibitory activity. A subsequent five-way randomized balanced controlled crossover clinical study evaluated the clinical pharmacokinetic interaction with single-dose felodipine. Grapefruit juice, water, or three of the in vitro tested coffees were ingested at 300 mL alone 1 h before and then with felodipine. In vitro, all six coffees decreased felodipine metabolism for both simultaneous and preincubation exposure compared to corresponding control. Five coffees demonstrated mechanism-based inhibition. Grapefruit increased felodipine AUC 0-8 (25 vs. 13 ng.h/mL, P coffees caused no change in these parameters compared to water. Despite high in vitro potency of CYP3A4 inhibition, the coffees did not cause a clinical pharmacokinetic interaction possibly from insufficient amount of inhibitor(s) in coffee reaching intestinal CYP3A4 during the absorption phase of felodipine. The results of this study highlight the need for follow-up clinical testing when in vitro results indicate the possibility of an interaction. © 2017 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British

  11. Rootstock effects on fruit quality among 'Ray Ruby' grapefruit trees grown in the Indian River district of Florida

    Science.gov (United States)

    The objective of this experiment was to compare fruit quality parameters of ‘Ray Ruby’ grapefruit grown on seven rootstocks. Four recent releases from the USDA rootstock breeding program, US-852, US-897, US-942 and US-812 (all Citrus reticulata x P. trifoliata hybrids), X639 (C. reticulata x P. tri...

  12. Quantification of 4'-geranyloxyferulic acid, a new natural colon cancer chemopreventive agent, by HPLC-DAD in grapefruit skin extract.

    Science.gov (United States)

    Genovese, S; Epifano, F; Carlucci, G; Marcotullio, M C; Curini, M; Locatelli, M

    2010-10-10

    Oxyprenylated natural products (isopentenyloxy-, geranyloxy- and the less spread farnesyloxy-compounds and their biosynthetic derivatives) represent a family of secondary metabolites that have been consider for years merely as biosynthetic intermediates of the most abundant C-prenylated derivatives. Many of the isolated oxyprenylated natural products were shown to exert in vitro and in vivo remarkable anti-cancer and anti-inflammatory effects. 4'-Geranyloxyferulic acid [3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic] has been discovered as a valuable chemopreventive agent of several types of cancer. After development of a high yield and "eco-friendly" synthetic scheme of this secondary metabolite, starting from cheap and non-toxic reagents and substrates, we developed a new HPLC-DAD method for its quantification in grapefruit skin extract. A preliminary study on C18 column showed the separation between GOFA and boropinic acid (having the same core but with an isopentenyloxy side chain), used as internal standard. The tested column were thermostated at 28+/-1 degrees C and the separation was achieved in gradient condition at a flow rate of 1 mL/min with a starting mobile phase of H(2)O:methanol (40:60, v/v, 1% formic acid). The limit of detection (LOD, S/N=3) was 0.5 microg/mL and the limit of quantification (LOQ, S/N=10) was 1 microg/mL. Matrix-matched standard curves showed linearity up to 75 microg/mL. In the analytical range the precision (RSD%) values were extract of grapefruit. In conclusion, this method showed LOQ values able to selective quantification of this analyte in grapefruit skin extract.

  13. Yield, Esterification Degree and Molecular Weight Evaluation of Pectins Isolated from Orange and Grapefruit Peels under Different Conditions

    Science.gov (United States)

    Sayah, Mohamed Yassine; Chabir, Rachida; Benyahia, Hamid; Rodi Kandri, Youssef; Ouazzani Chahdi, Fouad; Touzani, Hanan; Errachidi, Faouzi

    2016-01-01

    Orange (Citrus sinensis) and grapefruit (Citrus paradise) peels were used as a source of pectin, which was extracted under different conditions. The peels are used under two states: fresh and residual (after essential oil extraction). Organic acid (citric acid) and mineral acid (sulfuric acid) were used in the pectin extraction. The aim of this study is the evaluation the effect of extraction conditions on pectin yield, degree of esterification “DE” and on molecular weight “Mw”. Results showed that the pectin yield was higher using the residual peels. Moreover, both peels allow the obtainment of a high methoxyl pectin with DE >50%. The molecular weight was calculated using Mark-Houwink-Sakurada equation which describes its relationship with intrinsic viscosity. This later was determined using four equations; Huggins equation, kramer, Schulz-Blaschke and Martin equation. The molecular weight varied from 1.538 x1005 to 2.47x1005 g/mol for grapefruit pectin and from 1.639 x1005 to 2.471 x1005 g/mol for orange pectin. PMID:27644093

  14. Irradiation and fumigation effects on flavor, aroma and composition of grapefruit products

    International Nuclear Information System (INIS)

    Moshonas, M.G.; Shaw, P.E.

    1982-01-01

    Effects were evaluated on grapefruit treated to meet quarantine restrictions against Caribbean fruit fly infestation. Differences were found in flavor of fresh sections, fresh juice, and aroma of peel oil when obtained from fruit irradiated with x-rays, as compared with products from nonirradiated fruit. Flavor differences were found in all pasteurized juices from fruit irradiated at 5-60 krad. Vitamin C levels were significantly lower in juice from most irradiated fruit. Flavor differences were found in fresh and pasteurized juice from fruit treated with methyl bromide, and in pasteurized juice from fruit treated with ethylene dibromide. Aroma differences were found in peel oil from fruit treated with phosphine. (author)

  15. Liquid chromatography-electrospray ionization mass spectrometry analysis of limonoids and flavanois in seeds of grapefruits, other citrus species, and dietary supplements

    Science.gov (United States)

    A selective ultra-high performance liquid chromatography-didode array detector-quadrapole time of flight-mass spectrometry (UHPLC-DAD-QToF-MS) method has been developed to screen grapefruit seeds, and other citrus seed samples for limonoid aglycones, limonoid acids, limonoid glucosides and flavonoid...

  16. Grapefruit as a host for the West Indian fruit fly (Diptera: Tephritidae).

    Science.gov (United States)

    Mangan, Robert L; Thomas, Donald B; Moreno, Aleena Tarshis; Robacker, David

    2011-02-01

    The most common hosts for the West Indian fruit fly, Anastrepha obliqua (Macquart) (Diptera: Tephritidae) are fruit in the family Anacardiaceae (mango [Mangifera L.] and mombin [Spondias L.] species). However, similar to many of the tropical fruit flies of major economic importance, this species attacks several other families of crop fruit, including Annonaceae (cherimoya, Annona cherimola Mill.), Myrtaceae (guava, Psidium L.), Oxalidaceae (carambola, Averrhoa carambola L.), Passifloraceae (granadilla, Passiflora quadrangularis Mill.), and Sapotaceae [mamey sapote, Pouteria sapota (Jacq.) H. E. Moore & Steam]. In the family Rutaceae the economically important genus Citrus has been reported and until recently considered a host for this fruit fly. In this study, we reviewed the taxonomy of A. obliqua, tested specific chemicals that may inhibit oviposition, compared egg-to-adult survival of A. obliqua on preferred hosts and on grapefruit (Citrus X paradisi Macfad.), and measured fruit tissue-specific developmental rates of A. obliqua and the known citrus breeding Mexican fruit fly, Anastrepha ludens (Loew) (Diptera: Tephritidae), from egg to pupae. Our literature review shows much confusion concerning the taxonomy of this and related Anastrepha species, including synonymies and confusion with other species. The deterrent effect of the highest concentration of flavonoids for oviposition, although significant, was not absolute. Experiments carried out under laboratory conditions showed 15-40 times greater survival of A. ludens (whose preferred hosts include Rutaceae) on grapefruit compared with A. obliqua for both tree attached and harvested fruit. Experiments of survival of developing stages over time showed that the two species oviposit into different tissues in the fruit, and mortality is much higher for the West Indian fruit fly in the flavedo and albedo of the fruit compared with the Mexican fruit fly.

  17. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: I. An in vitro agar assay.

    Science.gov (United States)

    Reagor, Lee; Gusman, Jean; McCoy, Lana; Carino, Edith; Heggers, John P

    2002-06-01

    Grapefruit-seed extract (GSE) Citricidal has, in recent reports, been reported to be successful in combating a variety of common infectious agents. In our study, drops of concentrated grapefruit-seed extract were tested for antibacterial properties against a number of gram-positive and gram-negative organisms. Sixty-seven (67) distinct biotypes were tested for their susceptibilities to the GSE as well as to 5 other topical antibacterials (Silvadene, Sulfamylon, Bactroban, Nitrofurazone, and Silvadene, Nystatin). Wells were punched into Mueller-Hinton agar plates, which were then inoculated with the organism to be tested; each well was then inoculated with one of the antibacterial agents. After an overnight incubation period, the plates were checked for zones of bacterial susceptibility around the individual wells, with a measured susceptibility zone diameter of 10 mm or more considered a positive result. The GSE was consistently antibacterial against all of the biotypes tested, with susceptibility zone diameters equal to or greater than 15 mm in each case. Our preliminary data thus suggest an antibacterial characteristic to GSE that is comparable to that of proven topical antibacterials. Although the GSE appeared to have a somewhat greater inhibitory effect on gram-positive organisms than on gram-negative organisms, its comparative effectiveness against a wide range of bacterial biotypes is significant.

  18. Potentiation of the antiinflammatory effect of Anacardium occidentale (Linn.) stem-bark aqueous extract by grapefruit juice.

    Science.gov (United States)

    Ojewole, J A O

    2004-04-01

    In an attempt to scientifically appraise some of the ethnomedical uses of Anacardium occidentale Linn. (family: Anacardiaceae), the present study was undertaken to examine the antiinflammatory effect of the plant's stem-bark aqueous extract in rats. Young adult male Wistar rats weighing 250-300 g were used. The antiinflammatory effect of A. occidentale stem-bark aqueous extract alone and in combination with grapefruit (Citrus paradisi Macf.) juice was investigated on fresh egg albumin-induced rat paw edema. Like diclofenac (100 mg/kg p.o.), aqueous extract of A. occidentale stem-bark (800 mg/kg p.o.) produced time-related, sustained and significant reduction (p extract was found to be approximately 8-15 times less than that of diclofenac. Coadministration of grapefruit juice (5 ml/kg p.o.) with A. occidentale stem-bark aqueous extract (800 mg/kg p.o.) or diclofenac (100 mg/kg p.o.) significantly potentiated (p extract and diclofenac on fresh egg albumin-induced rat paw edema. Although A. occidentale stem-bark aqueous extract is less potent than diclofenac as an antiinflammatory agent, the results of this experimental animal study indicate that the plant extract possesses antiinflammatory activity, and thus lend pharmacological support to the folkloric use of the plant in the management and/or control of arthritis and other inflammatory conditions among the Yoruba-speaking people of western Nigeria.

  19. Antibacterial properties of grapefruit seed extract against Paenibacillus larvae subsp. larvae.

    Science.gov (United States)

    Semprini, P; Langella, V; Pasini, B; Falda, M T; Calvarese, S

    2004-01-01

    Twenty-one samples of grapefruit seed extract (GSE) either from marketed products or provided by an apiculturist were analysed to verify their inhibition activity, in particular against Paenibacillus larvae subsp. larvae, responsible for American foulbrood. The bactericide capacity of GSE has been measured in Bacillus subtilis BGA, Bacillus cereus 11778, Bacillus cereus K250 and Micrococcus luteus 9341a; these bacteria are normally used in the laboratory to study inhibitors. The results showed that not all GSE have the same inhibitory activity and two of those analysed do not inhibit the five bacteria used. Considering that 19 samples inhibited American foulbrood bacillus, the authors conclude that the use of a natural product (such as GSE) to control this important disease of bees, can be used as a substitute for chemotherapeutic products, after appropriate expedients.

  20. Validation of a quantitative NMR method for suspected counterfeit products exemplified on determination of benzethonium chloride in grapefruit seed extracts.

    Science.gov (United States)

    Bekiroglu, Somer; Myrberg, Olle; Ostman, Kristina; Ek, Marianne; Arvidsson, Torbjörn; Rundlöf, Torgny; Hakkarainen, Birgit

    2008-08-05

    A 1H-nuclear magnetic resonance (NMR) spectroscopy method for quantitative determination of benzethonium chloride (BTC) as a constituent of grapefruit seed extract was developed. The method was validated, assessing its specificity, linearity, range, and precision, as well as accuracy, limit of quantification and robustness. The method includes quantification using an internal reference standard, 1,3,5-trimethoxybenzene, and regarded as simple, rapid, and easy to implement. A commercial grapefruit seed extract was studied and the experiments were performed on spectrometers operating at two different fields, 300 and 600 MHz for proton frequencies, the former with a broad band (BB) probe and the latter equipped with both a BB probe and a CryoProbe. The concentration average for the product sample was 78.0, 77.8 and 78.4 mg/ml using the 300 BB probe, the 600MHz BB probe and CryoProbe, respectively. The standard deviation and relative standard deviation (R.S.D., in parenthesis) for the average concentrations was 0.2 (0.3%), 0.3 (0.4%) and 0.3mg/ml (0.4%), respectively.

  1. Evaluation of grapefruit seed extract as natural fungicide to control apple scab in organic apple growing

    OpenAIRE

    Trapman, Marc

    2004-01-01

    C-pro, an experimental fungicide based on grapefruit seed extract was compared to copper oxychloride for the control of apple scab in a field trial. Efficacy and possible phytotoxic effects where accessed. The C-pro formulation was analysed for possible chemical additives by HPTLC. C-pro proved tot be more effective in controlling apple scab then the standard rate of 300 gram copper oxychloride per ha, and gave a better leaf quality and less fruit skin russeting then the sta...

  2. Effects of Different Irrigation Programs on Fruit, Trunk Growth Rates, Quality and Yield of Grapefruit Trees

    OpenAIRE

    KANBER, Rıza; KÖKSAL, Harun; YAZAR, Attila; ÖZEKİCİ, Bülent; ÖNDER, Sermet

    1999-01-01

    Long-term field experiments were carried out between 1985 and 1988 to determine the effect of different irrigation intervals and pan coefficients on the fruit and trunk growth rates and yield of mature grapefruit trees grown in the Eastern Mediterranean Region of Turkey in a medium-light textured soil. Two different irrigation intervals (I 1 =15 and I 2 =25 days), and pan coefficients (k 1 =0.60 and k 2 =1.00) were used. Higher evapotranspiration values were obtained from the treatments with ...

  3. Ethanol extract grapefruit peel ( Citrus maxima Murr.) gel formulations with gelling agent durian seed gum and carboxy methyl cellulose

    OpenAIRE

    Nazliniwaty; Karsono; Zebua, Nilsya Febrika; Nerdy

    2017-01-01

    This research aims to investigate the best gel formula of grapefruit ethanol extracts (Citrus maxima Murr.) with gelling agent combination durian seed gum and carboxy methyl cellulose (CMC). Durian seed gum was isolated with centrifuge and then combined with CMC-Na in five formulas. Evaluation material of topical gel that is its homogeneity, pH, stability testing, and irritation of the volunteers. All formula gel preparations its ...

  4. First derivative versus absolute spectral reflectance of citrus varieties

    Science.gov (United States)

    Blazquez, Carlos H.; Nigg, H. N.; Hedley, Lou E.; Ramos, L. E.; Sorrell, R. W.; Simpson, S. E.

    1996-06-01

    Spectral reflectance measurements from 400 to 800 nm were taken from immature and mature leaves of grapefruit ('McCarty' and 'Rio Red'), 'Minneola' tangelo, 'Satsuma' mandarin, 'Dancy' tangerine, 'Nagami' oval kumquat, and 'Valencia' sweet orange, at the Florida Citrus Arboretum, Division of Plant Industry, Winter Haven, Florida. Immature and mature leaves of 'Minneola' tangelo had greater percent reflectance in the 400 to 800 nm range than the other varieties and leaf ages measured. The slope of the citrus spectral curves in the 800 nm range was not as sharp as conventional spectrometers, but had a much higher reflectance value than those obtained with a DK-2 spectrometer. Statistical analyses of absolute spectral data yielded significant differences between mature and immature leaves and between varieties. First derivative data analyses did not yield significant differences between varieties.

  5. A dark incubation period is important for Agrobacterium-mediated transformation of mature internode explants of sweet orange, grapefruit, citron, and a citrange rootstock.

    Science.gov (United States)

    Marutani-Hert, Mizuri; Bowman, Kim D; McCollum, Greg T; Mirkov, T Erik; Evens, Terence J; Niedz, Randall P

    2012-01-01

    Citrus has an extended juvenile phase and trees can take 2-20 years to transition to the adult reproductive phase and produce fruit. For citrus variety development this substantially prolongs the time before adult traits, such as fruit yield and quality, can be evaluated. Methods to transform tissue from mature citrus trees would shorten the evaluation period via the direct production of adult phase transgenic citrus trees. Factors important for promoting shoot regeneration from internode explants from adult phase citrus trees were identified and included a dark incubation period and the use of the cytokinin zeatin riboside. Transgenic trees were produced from four citrus types including sweet orange, citron, grapefruit, and a trifoliate hybrid using the identified factors and factor settings. The critical importance of a dark incubation period for shoot regeneration was established. These results confirm previous reports on the feasibility of transforming mature tissue from sweet orange and are the first to document the transformation of mature tissue from grapefruit, citron, and a trifoliate hybrid.

  6. Grapefruit and its biomedical, antigenotoxic and chemopreventive properties.

    Science.gov (United States)

    Cristóbal-Luna, José Melesio; Álvarez-González, Isela; Madrigal-Bujaidar, Eduardo; Chamorro-Cevallos, Germán

    2018-02-01

    Grapefruit (Citrus paradisi Mcfad) is a perenifolium tree 5-6 m high with a fruit of about 15 cm in diameter, protected by the peel we can find about 11-14 segments (carpels), each of which is surrounded by a membrane and each containing the juice sacs, as well as the seeds. The fruit is made up of numerous compounds, and is known to have nutritive value because of the presence of various vitamins and minerals, among other chemicals. The fruit is also used in the field of gastronomy. Information has been accumulated regarding the participation of the fruit structures in a variety of biomedical, antigenotoxic and chemopreventive effects, surely related with the presence of the numerous chemicals that have been determined to constitute the fruit. Such studies have been carried out in different in vitro and in vivo experimental models, and in a few human assays. The information published so far has shown interesting results, therefore, the aims of the present review are to initially examine the main characteristics of the fruit, followed by systematization of the acquired knowledge concerning the biomedical, antigenotoxic and chemopreventive effects produced by the three main structures of the fruit: peel, seed, and pulp. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review.

    Science.gov (United States)

    Chen, Meng; Zhou, Shu-Yi; Fabriaga, Erlinda; Zhang, Pian-Hong; Zhou, Quan

    2018-04-01

    This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance. The beneficial combinations included orange juice-ferrous fumarate, lemon juice- 99m Tc-tetrofosmin, pomegranate juice-intravenous iron during hemodialysis, cranberry juice-triple therapy medications for H. pylori, blueberry juice-etanercept, lime juice-antimalarials, and wheat grass juice-chemotherapy. The potential adverse interactions included decreased drug bioavailability (apple juice-fexofenadine, atenolol, aliskiren; orange juice-aliskiren, atenolol, celiprolol, montelukast, fluoroquinolones, alendronate; pomelo juice-sildenafil; grape juice-cyclosporine), increased bioavailability (Seville orange juice-felodipine, pomelo juice-cyclosporine, orange-aluminum containing antacids). Unlike furanocoumarin-rich grapefruit juice which could primarily precipitate drug interactions by strong inhibition of cytochrome P450 3A4 isoenzyme and P-glycoprotein and thus cause deadly outcomes due to co-ingestion with some medications, other fruit juices did not precipitate severely detrimental food-drug interaction despite of sporadic case reports. The extent of a juice-drug interaction may be associated with volume of drinking juice, fruit varieties, type of fruit, time between juice drinking and drug intake, genetic polymorphism in the enzymes or transporters and anthropometric variables. Pharmacists and health professionals should properly screen for and educate patients about potential adverse juice-drug interactions and help

  8. An Exposed-Core Grapefruit Fibers Based Surface Plasmon Resonance Sensor

    Directory of Open Access Journals (Sweden)

    Xianchao Yang

    2015-07-01

    Full Text Available To solve the problem of air hole coating and analyte filling in microstructured optical fiber-based surface plasmon resonance (SPR sensors, we designed an exposed-core grapefruit fiber (EC-GFs-based SPR sensor. The exposed section of the EC-GF is coated with a SPR, supporting thin silver film, which can sense the analyte in the external environment. The asymmetrically coated fiber can support two separate resonance peaks (x- and y-polarized peaks with orthogonal polarizations and x-polarized peak, providing a much higher peak loss than y-polarized, also the x-polarized peak has higher wavelength and amplitude sensitivities. A large analyte refractive index (RI range from 1.33 to 1.42 is calculated to investigate the sensing performance of the sensor, and an extremely high wavelength sensitivity of 13,500 nm/refractive index unit (RIU is obtained. The silver layer thickness, which may affect the sensing performance, is also discussed. This work can provide a reference for developing a high sensitivity, real-time, fast-response, and distributed SPR RI sensor.

  9. A dark incubation period is important for Agrobacterium-mediated transformation of mature internode explants of sweet orange, grapefruit, citron, and a citrange rootstock.

    Directory of Open Access Journals (Sweden)

    Mizuri Marutani-Hert

    Full Text Available BACKGROUND: Citrus has an extended juvenile phase and trees can take 2-20 years to transition to the adult reproductive phase and produce fruit. For citrus variety development this substantially prolongs the time before adult traits, such as fruit yield and quality, can be evaluated. Methods to transform tissue from mature citrus trees would shorten the evaluation period via the direct production of adult phase transgenic citrus trees. METHODOLOGY/PRINCIPAL FINDINGS: Factors important for promoting shoot regeneration from internode explants from adult phase citrus trees were identified and included a dark incubation period and the use of the cytokinin zeatin riboside. Transgenic trees were produced from four citrus types including sweet orange, citron, grapefruit, and a trifoliate hybrid using the identified factors and factor settings. SIGNIFICANCE: The critical importance of a dark incubation period for shoot regeneration was established. These results confirm previous reports on the feasibility of transforming mature tissue from sweet orange and are the first to document the transformation of mature tissue from grapefruit, citron, and a trifoliate hybrid.

  10. Response of foster grapefruit (Citrus paradisi Macf. to organic and inorganic fertilization in central Sudan

    Directory of Open Access Journals (Sweden)

    Abdalla A.M. Elhassan

    2011-06-01

    Full Text Available The response of Foster grapefruit (Citrus paradisi Macf. to organic and inorganic fertilization in Sennar area (13°37′N–33°37′E representing central Sudan, was studied for two successive seasons (2003/2004 and 2004/2005. Urea, sheep manure and terra-sorb (as foliar at the rates of 2.17 kg/tree/year, 20 kg/tree/year and 200 ml/100 L water, respectively, and their combinations were applied to 18 years old trees to determine their effects on fruit yield and quality. The layout was a randomized complete block design replicated three times. Results indicated that all treatments significantly increased average yield over control with inconsistent effects on fruit quality parameters. Trees received urea at the rate of 2.17 kg/tree/year, yielded thick peel fruits of reduced vitamin C. Sheep manure at the rate of 20 kg/tree/year resulted in dark green fruits of thick peel. The foliar treated trees at the rate of 200 ml/100 L water gave little thick peel fruits of lower total soluble solids, low % titrable acidity and low vitamin C. The best fruits reflected by color, thinner peel, high % TSS and high vitamin C were obtained from urea + sheep manure treatment. Application of urea with foliar gave green large fruits. Small fruits of intensive green color on surface and low titrable acidity were recorded by combination of sheep manure and foliar. Application of the three fertilizers together gave fruits of dark green color on surface and thick peel. Therefore, application of 2.17 kg urea + 20 kg sheep manure/tree/year is recommended to Foster grapefruit trees in Sennar area and areas of similar environmental conditions.

  11. Assessment of the viability of using saline reclaimed water in grapefruit in medium to long term

    Directory of Open Access Journals (Sweden)

    Cristina Romero-Trigueros

    2014-11-01

    Full Text Available Citrus trees are strongly affected by salinity, especially in countries where irrigation is required as a semi-arid Mediterranean agronomic region. The aims of the study were i to identify the best reliable plant-based water status indicator for field grown grapefruit trees irrigated with saline reclaimed water during five years of cultivation by measuring seasonal changes in physiological parameters (i.e. gas exchange and stem water potential measurements, leaf structural traits (i.e. leaf chlorophyll content, area-based leaf nitrogen and area-based dry mass, phytotoxic elements and yield; ii to estimate phytotoxicity thresholds at leaf level. Our results showed that the chlorophyll content was the parameter with the highest number of measures with significant differences (p≤0.05, ANOVA between trees irrigated with reclaimed water and control trees throughout growing stages. Moreover, Chl a increased linearly with area-based leaf nitrogen (R2=0.63; p<0.001 and area-based dry mass (R2=0.64; p<0.001. We also determined the salt-induced phytotoxicity thresholds at which a reduction in yields occurs; these levels were Na: 0.1 g/100 g, Cl: 0.6 g/100 gand B: 100 ppm. In conclusion, we revealed the importance of leaf chlorophyll measurements as a significance diagnostic indicator of salt stress on field grown grapefruit trees. This parameter was also related to plant-based water status indicators such as stem water potential, stomatal conductance and net photosynthesis. Additionally, a salt accumulation potential at leaf level was shown, leading to possible risk in crop sustainability in the medium to long term.

  12. Growth and sporulation of some pathogenic fungi in the presence of grapefruit extract.

    Science.gov (United States)

    Orlikowski, Leszek B; Skrzypczak, Cz; Jaworska-Marosz, A

    2002-01-01

    Development of Fusarium oxysporum f. sp. cyclaminis, F. oxysporum f. sp. dianthi, Botrytis cinerea and B. elliptica in the presence of grapefruit extract (GE) was evaluated. Amendment of potato-dextrose agar with 40 micrograms of GE/cm3 inhibited linear growth of tested species at least in 50%. Addition of 40 micrograms of GE/cm3 of medium inhibited spore germination of F. oxysporum f.sp. cyclaminis about 34% whereas germ tube growth was suppressed in 87%. In case of Botrytis species, B. cinerea spores were more susceptible on GE than B. elliptica. They did not germinate, however, at 200 micrograms of GE/cm3. Drenching of peat, artificially infested with F. oxysporum f. sp. dianthi, with GE at conc. 165 micrograms/cm3 resulted in drastical decrease of colony forming unit numbers and this suppressive effect was observed at least 35 days.

  13. Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review

    Directory of Open Access Journals (Sweden)

    Meng Chen

    2018-04-01

    Full Text Available This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs. Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance. The beneficial combinations included orange juice-ferrous fumarate, lemon juice-99mTc-tetrofosmin, pomegranate juice-intravenous iron during hemodialysis, cranberry juice-triple therapy medications for H. pylori, blueberry juice-etanercept, lime juice-antimalarials, and wheat grass juice-chemotherapy. The potential adverse interactions included decreased drug bioavailability (apple juice-fexofenadine, atenolol, aliskiren; orange juice-aliskiren, atenolol, celiprolol, montelukast, fluoroquinolones, alendronate; pomelo juice-sildenafil; grape juice-cyclosporine, increased bioavailability (Seville orange juice-felodipine, pomelo juice-cyclosporine, orange-aluminum containing antacids. Unlike furanocoumarin-rich grapefruit juice which could primarily precipitate drug interactions by strong inhibition of cytochrome P450 3A4 isoenzyme and P-glycoprotein and thus cause deadly outcomes due to co-ingestion with some medications, other fruit juices did not precipitate severely detrimental food–drug interaction despite of sporadic case reports. The extent of a juice-drug interaction may be associated with volume of drinking juice, fruit varieties, type of fruit, time between juice drinking and drug intake, genetic polymorphism in the enzymes or transporters and anthropometric variables. Pharmacists and health professionals should properly screen for and educate patients about potential adverse juice

  14. Photosynthesis, respiration and translocation in green fruit of normal and mutant grapefruit

    International Nuclear Information System (INIS)

    Koch, K.E.; Yen, C.R.; Avigne, W.T.

    1986-01-01

    Gas exchange, 14 CO 2 fixation/and subsequent photosynthate translocation were followed during a 24h light/dark period in green grapefruit (Citrus paradisi Macf.) detached after 2.5 mo. growth. Fruit photosynthesis could account for net fixation of less than 1% of the daily dry weight increase recorded for fruit at this stage of development, but a comparison of light/dark CO 2 exchange indicated that as much as 27% of this daily gain was maintained by refixation of respiratory CO 2 during daylight hours. Approximately 10% of photosynthates labeled in the outer peel (flavedo) were translocated to segment epidermis and juice vesicles of normal fruit during 1 + 23h pulse-chase experiments. This process typically continues for 4 to 5 days and refixation products would presumably follow the same path. In a low-acid mutant believed to differ only in acid/sugar ratio of juice vesicles, however, inward translocation of 14 C-photosynthates from flavedo was restricted primarily to the inner peel (albedo)

  15. Effect of hot water and gamma radiation on postharvest decay of grapefruit

    International Nuclear Information System (INIS)

    Spalding, D.H.; Reeder, W.F.

    1986-01-01

    'Marsh' seedless white Florida grapefruit (Citrus paradisi Macf.) were inoculated after harvest with a spore suspension of green mold (Penicillium digitatum Sacc.) and treated by immersion in hot water (50°C for 5 min) or irradiation with gamma rays (250 Gy) from a Cobalt-60 source or a combination of the two treatments. Fruit were wrapped individually with shrink film after hot water treatment and before irradiation and were stored with wrapped control fruit at 24°C for 9 days. Fruit treated with hot water developed less green mold rot than untreated fruit, even when treatment was delayed for 72 hr after inoculation. Fruit irradiated after a delay of 2 hr, but not 24-72 hr, after inoculation developed less rot than untreated fruit. Development of green mold rot was not significantly different in fruit treated with both hot water and irradiation than with hot water alone. No visible injury or off-flavors were detected in any of the fruit. (author)

  16. Development and validation of an HPLC/UV/MS method for simultaneous determination of 18 preservatives in grapefruit seed extract.

    Science.gov (United States)

    Ganzera, Markus; Aberham, Anita; Stuppner, Hermann

    2006-05-31

    Grapefruit seed extracts are used in cosmetics, food supplements, and pesticides because of their antimicrobial properties, but suspicions about the true nature of the active compounds arose when synthetic disinfectants such as benzethonium or benzalkonium chloride were found in commercial products. The HPLC method presented herein allows the quality assessment (qualitative and quantitative) of these products for the first time. On the basis of a standard mixture of 18 preservatives most relevant for food and grapefruit products, a method was developed allowing the baseline separation of all compounds within 40 min. Optimum results were obtained with a C-8 stationary phase and a solvent system comprising aqueous trifluoroacetic acid, acetonitrile, and 2-propanol. The assay was fully validated and shown to be sensitive (LOD or = 96.1%), repeatable (sigma(rel) < or = 3.5%), precise (intra-day variation < or = 4.5%, interday variation < or = 4.1%), and rugged. Without any modifications the method could be adopted for LC-MS experiments, where the compounds of interest were directly assignable in positive ESI mode. The quantitative results of several products for ecofarming confirmed previous studies, as seven out of nine specimens were adulterated with preservatives in varying composition. The samples either contained benzethonium chloride (2.5-176.9 mg/mL) or benzalkonium chloride (138.2-236.3 mg/mL), together with smaller amounts of 4-hydroxybenzoic acid esters, benzoic acid, and salicylic acid.

  17. RIO EPICS device support application case study on an ion source control system (ISHP)

    Energy Technology Data Exchange (ETDEWEB)

    Sanz, Diego [UPM – Universidad Politécnica de Madrid, Madrid (Spain); Ruiz, Mariano, E-mail: mariano.ruiz@upm.es [UPM – Universidad Politécnica de Madrid, Madrid (Spain); Eguiraun, Mikel [Department of Electricity and Electronic, Faculty of Science and Technology, University of Basque Country, Bilbao (Spain); Arredondo, Iñigo [ESS Bilbao Consortium, Zamudio (Spain); Badillo, Inari; Jugo, Josu [Department of Electricity and Electronic, Faculty of Science and Technology, University of Basque Country, Bilbao (Spain); Vega, Jesús; Castro, Rodrigo [Asociación EURATOM/CIEMAT, Madrid (Spain)

    2015-10-15

    Highlights: • A use case example of RIO/FlexRIO design methodology is described. • Ion source device is controlled and monitored by means EPICS IOCs. • NIRIO EPICS device support demonstrates that is able to manage RIO devices. • Easy and fast deployment is possible using RIO/FlexRIO design methodology using NIRIO-EDS. • RIO/FlexRIO technology and EPICS are a good combination for support large scale experiments in fusion environments. - Abstract: Experimental Physics and Industrial Control System (EPICS) is a software tool that during last years has become relevant as a main framework to deploy distributed control systems in large scientific environments. At the moment, ESS Bilbao uses this middleware to perform the control of their Ion Source Hydrogen Positive (ISHP) project. The implementation of the control system was based on: PXI Real Time controllers using the LabVIEW-RT and LabVIEW-EPICS tools; and RIO devices based on Field-Programmable Gate Array (FPGA) technology. Intended to provide a full compliant EPICS IOCs for RIO devices and to avoid additional efforts on the system maintainability, a migration of the current system to a derivative Red Hat Linux (CentOS) environment has been conducted. This paper presents a real application case study for using the NIRIO EPICS device support (NIRIO-EDS) to give support to the ISHP. Although RIO FPGA configurations are particular solutions for ISHP performance, the NIRIO-EDS has permitted the control and monitoring of devices by applying a well-defined design methodology into the previous FPGA configuration for RIO/FlexRIO devices. This methodology has permitted a fast and easy deployment for the new robust, scalable and maintainable software to support RIO devices into the ISHP control architecture.

  18. Inhibition selectivity of grapefruit juice components on human cytochromes P450.

    Science.gov (United States)

    Tassaneeyakul, W; Guo, L Q; Fukuda, K; Ohta, T; Yamazoe, Y

    2000-06-15

    Five compounds including furanocoumarin monomers (bergamottin, 6', 7'-dihydroxybergamottin (DHB)), furanocoumarin dimers (4-¿¿6-hydroxy-71-¿(1-hydroxy-1-methyl)ethyl-4-methyl-6-(7-oxo-7H- furo¿3,2-g1benzopyran-4-yl)-4-hexenyl]oxy]-3,7-dimethyl- 2-octenyl]oxy]-7H-furo[3,2-g]¿1benzopyran-7-one (GF-I-1) and 4-¿¿6-hydroxy-7¿¿4-methyl-1-(1-methylethenyl)-6-(7-oxo-7H-furo¿3, 2-g1benzopyran-4-yl)-4-hexenylŏxy-3, 7-dimethyl-2-octenylŏxy-7H-furo¿3,2-g1benzopyran-7-one (GF-I-4)), and a sesquiterpene nootkatone have been isolated from grapefruit juice and screened for their inhibitory effects toward human cytochrome P450 (P450) forms using selective substrate probes. Addition of ethyl acetate extract of grapefruit juice into an incubation mixture resulted in decreased activities of CYP3A4, CYP1A2, CYP2C9, and CYP2D6. All four furanocoumarins clearly inhibited CYP3A4-catalyzed nifedipine oxidation in concentration- and time-dependent manners, suggesting that these compounds are mechanism-based inhibitors of CYP3A4. Of the furanocoumarins investigated, furanocoumarin dimers, GF-I-1 and GF-I-4, were the most potent inhibitors of CYP3A4. Inhibitor concentration required for half-maximal rate of inactivation (K(I)) values for bergamottin, DHB, GF-I-1, and GF-I-4 were calculated, respectively, as 40.00, 5. 56, 0.31, and 0.13 microM, whereas similar values were observed on their inactivation rate constant at infinite concentration of inhibitor (k(inact), 0.05-0.08 min(-1)). Apparent selectivity toward CYP3A4 does occur with the furanocoumarin dimers. In contrast, bergamottin showed rather stronger inhibitory effect on CYP1A2, CYP2C9, CYP2C19, and CYP2D6 than on CYP3A4. DHB inhibited CYP3A4 and CYP1A2 activities at nearly equivalent potencies. Among P450 forms investigated, CYP2E1 was the least sensitive to the inhibitory effect of furanocoumarin components. A sesquiterpene nootkatone has no significant effect on P450 activities investigated except for CYP2A6 and CYP2C19

  19. 7 CFR 906.340 - Container, pack, and container marking regulations.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Container, pack, and container marking regulations... AGRICULTURE ORANGES AND GRAPEFRUIT GROWN IN LOWER RIO GRANDE VALLEY IN TEXAS Container and Pack Requirements § 906.340 Container, pack, and container marking regulations. (a) No handler shall handle any variety of...

  20. Raptor Use of the Rio Grande Gorge

    Energy Technology Data Exchange (ETDEWEB)

    Ponton, David A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-03-20

    The Rio Grande Gorge is a 115 km long river canyon located in Southern Colorado (15 km) and Northern New Mexico (100 km). The majority of the canyon is under the administration of the Bureau of Land Management {BLM), and 77 km of the canyon south of the Colorado/New Mexico border are designated Wild River under the National Wild and Scenic Rivers Act of 1968. Visits I have made to the Rio Grande Gorge over the past 15 .years disclosed some raptor utilization. As the Snake River Birds of Prey Natural Area gained publicity, its similarity to the Rio Grande Gorge became obvious, and I was intrigued by the possibility of a high raptor nesting density in the Gorge. A survey in 1979 of 20 km of the northern end of the canyon revealed a moderately high density of red-tailed hawks and prairie falcons. With the encouragement of that partial survey, and a need to assess the impact of river-running on nesting birds of prey, I made a more comprehensive survey in 1980. The results of my surveys, along with those of a 1978 helicopter survey by the BLM, are presented in this report, as well as general characterization of the area, winter use by raptors, and an assessment of factors influencing the raptor population.

  1. Characterization of clay used for red ceramic fabrication

    International Nuclear Information System (INIS)

    Pereira, P.S.; Morais, A.S.C.; Caldas, T.C.C.; Monteiro, S.N.; Vieira, C.M.F.

    2011-01-01

    The objective of this work is to characterize a clay used in the red ceramics fabrication, from Campos dos Goytacazes north of the State of Rio de Janeiro. The clay was submitted for physical, chemical and mineralogical tests. The results showed that the clay has a high content of clay minerals with kaolinitic predominance, high loss on ignition and low flux oxides. It is recommended that this clay is mixed with non-plastic materials. (author)

  2. In vitro interactions with repeated grapefruit juice administration--to peel or not to peel?

    Science.gov (United States)

    Brill, Shlomo; Zimmermann, Christian; Berger, Karin; Drewe, Juergen; Gutmann, Heike

    2009-03-01

    Interactions of acutely administered grapefruit juice (GFJ) with cytochrome P450 isoform 3A4 (CYP3A4) and P-glycoprotein (Pgp) function are well established. In this study, we investigated in vitro the effect of repeated administration of GFJ and its major constituents (the flavonoid naringin, its aglycone naringenin and the furanocoumarin bergamottin) on mRNA expression of MDR1 and CYP3A4 in LS180 cells. Since the bergamottin content is higher in the peel than in the fruit, we compared GFJ containing peel (GFJP+) with juice without any peel extract (GFJP-). GFJP- (1%) showed no significant effect on MDR1 and CYP3A4 mRNA expression, whereas 1% GFJP+ increased expression of MDR1 3.7-fold (Pextract may have a lower potential for interactions with CYP3A4 or P-glycoprotein.

  3. Antibacterial effect of grapefruit seed extract (GSE) on Makgeolli-brewing microorganisms and its application in the preservation of fresh Makgeolli.

    Science.gov (United States)

    Choi, Jae-Suk; Lee, Yu-Ri; Ha, Yu-Mi; Seo, Hyo Ju; Kim, Young Hun; Park, Sun-Mee; Sohn, Jae Hak

    2014-06-01

    To develop a new preservation method, the antimicrobial activity of grapefruit seed extract (GSE) against Makgeolli-brewing microorganisms and food-borne pathogens was assessed, and a general analysis and sensory evaluation of fresh Makgeolli with added GSE was made. The minimum inhibitory concentration (MIC) values of GSE against 10 strains of Makgeolli-brewing microorganism were 0.0122 to 1.5625 μL/mL. The MIC values against 6 strains of food-borne pathogens were 0.0061 to 0.7813 μL/mL. On addition of 0.1% (v/v) and 0.2% GSE in bottled fresh Makgeolli, no significant difference in the pH, or the contents of total acids, ethanol, or methanol in the Makgeolli, were observed compared with control Makgeolli (with no GSE), during the preservation period (8 weeks) at 10 °C. In the Makgeolli with 0.1% and 0.2% GSE, the total bacterial counts decreased significantly by 4.9% (P grapefruit seed extract (GSE) was developed. As fresh Makgeolli contains live microorganisms, the preservation period is 1 wk, which is relatively short. GSE controls the growth of Makgeolli-brewing and Makgeolli-spoiling microorganisms. 0.1% to 0.2% GSE is optimum for prolonging the shelf life (2 wk) of bottled fresh Makgeolli, and has no adverse effect on overall acceptability. We demonstrated that GSE is an effective natural additive that prolongs the shelf life of fresh Makgeolli with no significant loss in quality. © 2014 Institute of Food Technologists®

  4. 7 CFR 906.123 - Fruit for processing.

    Science.gov (United States)

    2010-01-01

    ... LOWER RIO GRANDE VALLEY IN TEXAS Rules and Regulations § 906.123 Fruit for processing. (a) No person... limited to, the following information: (1) Name and address of applicant; (2) Location of plant or plants... issued thereunder (7 CFR part 46) when buying Texas oranges and grapefruit for processing; (6) A...

  5. Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes.

    Science.gov (United States)

    Girennavar, Basavaraj; Poulose, Shibu M; Jayaprakasha, Guddadarangavvanahally K; Bhat, Narayan G; Patil, Bhimanagouda S

    2006-04-15

    Bioactive compounds present in grapefruit juice are known to increase the bioavailability of certain medications by acting as potent CYP 3A4 inhibitors. An efficient technique has been developed for isolation and purification of three furocoumarins. The isolated compounds have been tested for the inhibition of human CYP 1B1 isoform using specific substrates. Grapefruit juice was extracted with ethyl acetate (EtOAc) and the dried extract was loaded onto silica gel column chromatography. Further, column fractions were subjected to preparative HPLC to obtain three compounds. The purity of these compounds was analyzed by HPLC and structures were determined by NMR studies. The identified compounds, bergamottin, 6',7'-dihydroxybergamottin (DHB), and paradisin-A, were tested for their inhibitory effects on hydroxylase and O-dealkylase activities of human cytochrome P450 isoenzymes CYP 3A4 and CYP 1B1. Paradisin-A was found to be a potent CYP 3A4 inhibitor with an IC50 of 1.2 microM followed by DHB and bergamottin. All three compounds showed a substantial inhibitory effect on CYP 3A4 below 10 microM. Inhibitory effects on CYP 1B1 exhibited a greater variation due to the specificity of substrates. Paradisin A showed an IC50 of 3.56+/-0.12 microM for the ethoxy resorufin O-dealkylase (EROD) activity and 33.56+/-0.72 microM for the benzyloxy resorufin (BROD). DHB and bergamottin showed considerable variations for EROD and BROD activities with an IC50 of 7.17 microM and 13.86 microM, respectively.

  6. Cecal parameters of rats fed diets containing grapefruit polyphenols and inulin as single supplements or in a combination.

    Science.gov (United States)

    Zduńczyk, Zenon; Juśkiewicz, Jerzy; Estrella, Isabel

    2006-09-01

    We compared the effects of grapefruit flavonoids and inulin, as single dietary components or in a combination, on cecal fermentation in rats adapted to a semipurified diet. The experimental diets contained 0.3% flavonoid extract and 5% or 10% inulin and a combination of both supplements. The large bowel metabolism assessment was based on cecal parameters: bulk effect, pH, microbial enzymes activity, and short-chain fatty acid production. Both supplements induced significant enlargement of the cecal digesta weight. Acidification of cecal digesta was more pronounced, with a higher inulin addition to the diet. Cecal pH was the highest with the flavonoid-rich diets and lowest in the case of a simultaneous addition of flavonoids and a high content of inulin. The flavonoid extract applied as a single dietary supplement was observed to decrease the activity of bacterial beta-glucosidase and beta- and alpha-galactosidases in the cecal digesta. In contrast, addition of the grapefruit extract to inulin-containing diets increased the activity of alpha-glucosidase, alpha-galactosidase, and beta-galactosidase. Great accumulation of cecal digesta in rats consuming the flavonoid-diet caused a considerable increase in the short-chain fatty acid pool, mainly acetic acid. Inulin added to the diet decreased the excessive enlargement of digesta caused by dietary flavonoids. Dietary addition of inulin to the flavonoid-diet also normalized hydration of cecal digesta and significantly decreased the pH of digesta. The presence of polyphenols in the inulin-containing diets did not change total short-chain fatty acid production in the cecum of rats. Our results suggested that simultaneous intake of inulin and polyphenols can decrease the detrimental effects of the latter on cecal fermentation.

  7. Lycopene: Senyawa Fitokimia Pada Tomat dan Semangka

    OpenAIRE

    Siagian, Albiner

    2010-01-01

    Lycopene is the predominant carotenoid in tomatoe and watermelon. It contributes to the brilliant hue-especially red-of many fruits and vegetables. It gives the red colour of tomato, watermelon, and pink grapefruit. Growing evidence suggests that lycopene has significant antioxidant potential. Other studies showed that low concentration of serum lycopene associated with the increased risk of atherosclerosis. Also, clinical and epidemiological evidence have showed that lycopene...

  8. Day and night feeding habitat of Red Knots in Patagonia : Profitability versus safety?

    NARCIS (Netherlands)

    Sitters, HP; Gonzalez, PM; Piersma, T; Baker, AJ; Price, DJ; Sitters, Humphrey P.; González, Patricia M.; Baker, Allan J.; Price, David J.

    2001-01-01

    By radio-tracking and recording the movements of flocks. the distribution of feeding Red Knots (Calidris canutus rufa) was studied day and night at a migration stopover site near San Antonio Oeste, Rio Negro, Argentina in March and April 1998. By day, the birds fed in dense flocks of 500-4000 on an

  9. Avaliação da genotoxicidade em mulheres com síndrome dos ovários policísticos: impacto da dieta

    OpenAIRE

    Soares, Nayara Pereira

    2015-01-01

    Introdução: Síndrome dos Ovários Policísticos (SOP), segundo o critério de Rotterdam, está presente em 6-12% das mulheres em idade reprodutiva, é caracterizada pelo hiperandrogenismo, resistência à insulina (RI) e por seu estado inflamatório, fatores comumente exacerbados pela presença da obesidade e associados com o aumento da genotoxicidade. Alimentação saudável com implicação na perda de peso atua restabelecendo as funções reprodutivas e metabólicas na SOP, entretanto sua influência na red...

  10. Stability of micronutrients and phytochemicals of grapefruit jam as affected by the obtention process.

    Science.gov (United States)

    Igual, M; García-Martínez, E; Camacho, M M; Martínez-Navarrete, N

    2016-04-01

    Fruits are widely revered for their micronutrient properties. They serve as a primary source of vitamins and minerals as well as of natural phytonutrients with antioxidant properties. Jam constitutes an interesting way to preserve fruit. Traditionally, this product is obtained by intense heat treatment that may cause irreversible loss of these bioactive compounds responsible for the health-related properties of fruits. In this work, different grapefruit jams obtained by conventional, osmotic dehydration (OD) without thermal treatment and/or microwave (MW) techniques were compared in terms of their vitamin, organic acid and phytochemical content and their stability through three months of storage. If compared with heating, osmotic treatments lead to a greater loss of organic acids and vitamin C during both processing and storage. MW treatments permit jam to be obtained which has a similar nutritional and functional value than that obtained when using a conventional heating method, but in a much shorter time. © The Author(s) 2015.

  11. Responses of the Asian citrus psyllid to volatiles emitted by the flushing shoots of its rutaceous host plants.

    Science.gov (United States)

    Patt, J M; Sétamou, M

    2010-04-01

    Diaphorina citri Kuwayama (Hemiptera: Psyllidae) carries Candidatus liberibacter spp., the putative causal agents of Huanglongbing. D. citri reproduces and develops only on the flushing shoots of its rutaceous host plants. Here we examined whether D. citri is attracted to host plant odors and a mixture of synthetic terpenes. Tests conducted in a vertically oriented Y-tube olfactometer showed that both males and females preferentially entered the Y-tube arm containing the odor from the young shoots of Murraya paniculata (L.) Jack and Citrus limon L. Burm. f. cultivar Eureka. Only males exhibited a preference for the odor of C. sinensis L., whereas the odor of C. x paradisi MacFadyen cultivar Rio Red was not attractive to both sexes. The volatiles emitted by young shoots of grapefruit cultivar Rio Red, Meyer lemon (Citrus x limon L. Burm.f.), and M. paniculata were analyzed by gas chromatograph-mass spectrometry. The samples were comprised of monoterpenes, monoterpene esters, and sesquiterpenes. The number of compounds present varied from 2 to 17, whereas the total amount of sample collected over 6 h ranged from 5.6 to 119.8 ng. The quantitatively dominant constituents were (E)-beta-ocimene, linalool, linalyl acetate, and beta-caryophyllene. The attractiveness of a mixture of synthetic terpenes, modeled on the volatiles collected from M. paniculata, was evaluated in screened cages in a no-choice test. At three observation intervals, significantly more individuals were trapped on white targets scented with the mixture than on unscented targets. These results indicate the feasibility of developing D. citri attractants patterned on actual host plant volatiles.

  12. Chitosan-based microcapsules containing grapefruit seed extract grafted onto cellulose fibers by a non-toxic procedure.

    Science.gov (United States)

    Alonso, Diana; Gimeno, Miquel; Sepúlveda-Sánchez, José D; Shirai, Keiko

    2010-04-19

    A novel non-toxic procedure is described for the grafting of chitosan-based microcapsules containing grapefruit seed oil extract onto cellulose. The cellulose was previously UV-irradiated and then functionalized from an aqueous emulsion of the chitosan with the essential oil. The novel materials are readily attained with durable fragrance and enhanced antimicrobial properties. The incorporation of chitosan as determined from the elemental analyses data was 16.08+/-0.29 mg/g of sample. Scanning electron microscopy (SEM) and gas chromatography-mass spectroscopy (GC-MS) provided further evidence for the successful attachment of chitosan microcapsules containing the essential oil to the treated cellulose fibers. The materials thus produced displayed 100% inhibition of Escherichia coli and Staphylococcus epidermidis up to 48 h of incubation. Inhibition of bacteria by the essential oil was also evaluated at several concentrations. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  13. The social network of alcohol users undergoing treatment in a mental health service Red social de adictos al alcohol bajo tratamiento en un servicio de salud mental Rede social de usuários de álcool, sob tratamento, em um serviço de saúde mental

    Directory of Open Access Journals (Sweden)

    Jacqueline de Souza

    2011-02-01

    Full Text Available The treatment of alcohol and drug users requires an extended reflection on the influence of the family and other social network groups of these individuals. Thus, this study, results of a qualitative study, aimed at investigating the presence of drug users in the social network of individuals undergoing treatment and the possible interventions of the mental health services in the social network of four users of alcohol in the municipality of Alegrete/RS. Interviews with users and families, genograms and eco-maps were used. The results indicated the presence of drug users in the family and in the other social network groups, and that the group for chemical dependants was the main intervention in these social networks. These results demonstrate the need for directing the actions of mental health to develop healthy bonds, to expand the social network and structure of the group in order to provide benefits which favor effective psychosocial rehabilitation.El tratamiento de adictos al alcohol y drogas requiere una reflexión amplia sobre la influencia de la familia y otros grupos de la red social de estos individuos. Así, este estudio, resultado de una investigación cualitativa, objetivó averiguar la presencia de usuarios de drogas en la red social de individuos bajo tratamiento y las posibles intervenciones del servicio de salud mental en la red social de cuatro adictos al alcohol en el municipio de Alegrete/ RS. Fueron utilizadas entrevistas con adictos y familiares, genograma y ecomapa. Los resultados indicaron la presencia de adictos de drogas en la familia y demás grupos de las redes sociales y el grupo para dependientes químicos como principal intervención en estas redes sociales. Estos resultados evidencian la necesidad de dirigir las acciones de salud mental para el desarrollo de vínculos saludables, ampliación de la red social y estructuración del grupo de modo a proporcionar beneficios en pro de una efectiva rehabilitaci

  14. Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine

    Science.gov (United States)

    Damkier, Per; Hansen, Lone L; Brøsen, Kim

    1999-01-01

    Aims In vitro studies suggest that the oxidation of quinidine to 3-hydroxyquinidine is a specific marker reaction for CYP3A4 activity. To assess the possible use of this reaction as an in vivo marker of CYP3A4 activity, we studied the involvement of cytochromes CYP2C9, CYP2E1 and CYP3A4 in the in vivo oxidative metabolism of quinidine. Methods An open study of 30 healthy young male volunteers was performed. The pharmacokinetics of a 200 mg single oral dose of quinidine was studied before and during daily administration of 100 mg diclofenac, a CYP2C9 substrate (n=6); 200 mg disulfiram, an inhibitor of CYP2E1 (n=6); 100 mg itraconazole, an inhibitor of CYP3A4 (n=6); 250 ml single strength grapefruit juice twice daily, an inhibitor of CYP3A4 (n=6); 250 mg of erythromycin 4 times daily, an inhibitor of CYP3A4 (n=6). Probes of other enzyme activities, caffeine (CYP1A2), sparteine (CYP2D6), mephenytoin (CYP2C19), tolbutamide (CYP2C9) and cortisol (CYP3A4) were also studied. Results Concomitant administration of diclofenac reduced the partial clearance of quinidine by N-oxidation by 27%, while no effect was found for other pharmacokinetic parameters of quinidine. Concomitant administration of disulfiram did not alter any of the pharmacokinetic parameters of quinidine. Concomitant administration of itraconazole reduced quinidine total clearance, partial clearance by 3-hydroxylation and partial clearance by N-oxidation by 61, 84 and 73%, respectively. The renal clerance was reduced by 60% and the elimination half-life increased by 35%. Concomitant administration of grapefruit juice reduced the total clearance of quinidine and its partial clearance by 3-hydroxylation and N-oxidation by 15, 19 and 27%, respectively. The elimination half-life of quinidine was increased by 19%. The caffeine metabolic index was reduced by 25%. Concomitant administration of erythromycin reduced the total clearance of quinidine and its partial clearance by 3-hydroxylation and N-oxidation by 34, 50

  15. Rio+20

    Directory of Open Access Journals (Sweden)

    Robert Horn

    2012-10-01

    Full Text Available This reflection on Rio+20 examines many of the major social institutions and how they fulfilled their functions during the United Nations Conference on Sustainable Development at Rio. The institutions are: 1. Nation-states as a collective. 2. Individual nation-states. 3. Vanguard institutions (some NGOs. 4. Action and convening NGOs. 5. Global media. 6. Governments of nation-states acting domestically 7. Individual governments in bilateral and multilateral situations. 8. Similar institutions in different countries acting together. 9. Businesses. 10. Global science. Each is considered within the assumptions of what the society expects them to deliver (in general, what is possible for them to deliver, and what they did deliver at Rio. In approaching Rio+20, our account differs considerably from much of the reportage by the mainstream media.

  16. COMPARTIMENTAÇÃO MORFOMÉTRICA DA BACIA DO RIO COCO COMO SUBSÍDIO A ANÁLISE DE FRAGILIDADE AMBIENTAL

    Directory of Open Access Journals (Sweden)

    Rejane Freitas Benevides Almeida

    2016-01-01

    Full Text Available El presente estudio tuvo como objetivo realizar la compartimentación morfométrica de la Cuenca Hidrográ - fica del Rio Coco. Para esto, fue realizada la digitalización manual de la red hidrográfica en escala 1:5.000 en ArcGis 10.1 a partir de imágenes do satélite RapidEye, siendo utilizada la metodología propuesta por Strahler (1952 para la jerarquización de la red de drenaje. La compartimentación de la cuenca fue realizada en el programa ArcGis 10.1 con base en el análisis del drenaje y el paisaje (hidrografía e relieve. Fueron definidos 05 compartimientos (sub-cuencas, siendo: Sub-cuenca del Ribeirão Prata, Sub-cuenca del Ribei - rão Piedade, Sub-cuenca del Ribeirão Surubim, Sub-cuenca del Alto Rio Coco y Sub-cuenca del Bajo Rio Coco, para los cuales fueron aplicados parámetros morfométricos, conforme las metodologías descriptas en los trabajos de Horton (1945, Christofoletti (1969 y Strahler (1952. A partir del análisis realizado se puede observar que las sub-cuencas del Alto Rio Coco y del Ribeirão Piedade fueron los compartimientos que presentaron mayores fragilidades naturales en relación a las demás sub-cuencas, situación verificada con los resultados del análisis morfométrico realizado, requiriendo por tanto una atención especial en relación al uso y ocupación del suelo.

  17. "Buzz marketing" : estudo de caso da marca Red Bull

    OpenAIRE

    Conceição, Miguel David

    2012-01-01

    Este relatório é baseado no estágio efetuado na agência de publicidade Ogilvy & Mather e é dedicado à temática do Buzz Marketing. De modo a poder explorar a fundo as dinâmicas deste tema foi feita uma análise à estratégia de marketing da marca Red Bull, considerada como um dos principais estudos de caso no âmbito do Buzz Marketing. Este tema pode ser definido como uma estratégia de marketing inovadora cujo objetivo principal é a criação de conversas entre os consumidores, colocando-os a falar...

  18. O RIO CAPITAL IMAGINADO PELA CRÍTICA CINEMATOGRÁFICA: os casos de Rio Fantasia e Rio, 40 graus

    Directory of Open Access Journals (Sweden)

    Eliska Altmann

    Full Text Available No artigo, busca-se verificar como o Rio de Janeiro, “cidade-capital”, foi imaginado por críticos cinematográficos brasileiros. Por meio de críticas aos filmes Rio fantasia (1957, de Watson Macedo, e Rio, 40 graus (1955, de Nelson Pereira dos Santos, pretende-se entender como a então Capital Federal foi descrita e legitimada por agentes que formam julgamentos, quiçá, para a posteridade.

  19. Environmental impact assessment, from Rio-92 to Rio+20 and beyond

    Directory of Open Access Journals (Sweden)

    Luis E. Sánchez

    2012-12-01

    Full Text Available The 1992 Rio Earth Summit was of paramount importance in the consolidation and international dissemination of environmental impact assessment, officially recognized as a tool for informed decision-making towards sustainable development (Principle 17, Rio Declaration and for protection of biodiversity (Article 14, Convention on Biological Diversity. A significant development afterwards was the strengthening of strategic environmental assessment in the design of policies, plans and programs. Both forms of impact assessment can establish the necessary connections between one goal of the Rio+20 Conference - reaching an agreement on the transition to a green economy - and the underpinning decision making processes. Although the Rio+20 Summit has faced challenges to acknowledge its potential, impact assessment should be strengthened in support of both government and business decisions.La Cumbre de la Tierra de 1992 fue de la más grande importancia en la consolidación y diseminación de la evaluación de impacto ambiental, oficialmente reconocida como una herramienta para la toma de decisiones informada hacia el desarrollo sostenible (Principio 17, Declaración de Rio y para la protección de la biodiversidad (Artículo 14, Convención de la Diversidad Biológica. Un avanzo posterior importante fue el fortalecimiento de la evaluación ambiental estratégica en la preparación de políticas, planos y programas. Ambas formas de evaluación de impacto son capaces de establecer los necesarios vínculos entre un objetivo declarado de la Conferencia Rio+2- - llegar a un acuerdo sobre la transición para una economía verde - y los procesos decisorios subyacentes. Aunque la Cumbre Rio+20 tenga encontrado dificultades en reconocer su potencial, la evaluación de impactos debería ser fortalecida en soporte de decisiones gubernamentales y privadas.A Cúpula da Terra de 1992, no Rio de Janeiro, teve a maior importância na consolidação e dissemina

  20. Rio+20 ou Rio-20?: crônica de um fracasso anunciado

    Directory of Open Access Journals (Sweden)

    Roberto Pereira Guimarães

    2012-12-01

    Full Text Available Passadas quatro décadas da Conferência de Estocolmo sobre o Meio Ambiente Humano, e decorridos apenas alguns meses da Rio+20, parece apropriado analisar o caminho percorrido a partir de Rio-92 e os desafios, em grande parte frustrados, da conferência recém concluída no Rio de Janeiro. Para tais propósitos, são analisados os avanços e retrocessos da agenda global de desenvolvimento sustentável, do processo preparatório e dos resultados alcançados no Rio em Junho de 2012, como também das ameaças provocadas pela nova agenda de segurança estratégica após os eventos de 11 Setembro de 2001 e pela crise econômica e financeira que já dura praticamente uma década. O artigo conclui com as perspectivas da agenda internacional nos próximos anos.Pasadas cuatro décadas desde la Conferencia de Estocolmo sobre Medio Ambiente Humano, y transcorridos tan solo algunos meses de la Rio+20, pareciera apropiado analisar el camino percorrido a partir de la Rio-92 y los desafíos, en grande parte frustrados, de la conferencia recien concluída en Rio de Janeiro. Para tales propósitos, serán analisados los avances e retrocesos en la agenda global de desarrollo sustentable, en el proceso preparatorio y en los resultados alcanzados en Rio en Junho de 2012, como también de las amenazas provocadas por la nueva agenda de segurida estratégica luego de los eventos de 11 Setembro de 2001 y por la crisis económica y financiera que ya dura prácticamente una década. El artículo concluye con las perspectivas de la agenda internacional em los próximos anos.After four decades since the Stockholm Conference on the Human Environment and after just a few months of Rio+20, it seems appropriate to assess the path followed since Rio+92 and the challenges, mostly frustrated, posed by Rio+20 . For this purpose, it is analyzed the advances and shortcomings of the global agenda of sustainable development, of the preparatory process and the results achieved in Rio

  1. Role of catechins in the antioxidant capacity of an active film containing green tea, green coffee, and grapefruit extracts.

    Science.gov (United States)

    Colon, M; Nerin, C

    2012-10-03

    The oxygen radical absorbance capacity (ORAC) method was used to characterize the antioxidant capacity of natural extracts of green tea, green coffee, and grapefruit. These natural extracts were incorporated into a plastic film layer, which was subsequently subjected to a free radical gas stream in order to determine the antioxidant capacity directly in the active film. The green tea extract (GTE) afforded the strongest antioxidant activity. To identify the active compounds in the extract, concentration of the diverse catechins in samples were determined by HPLC-UV analysis. The results showed that the content of catechins in the GTE is around 77% (w/w), the major components being (-)-epigallocatechin gallate, (-)-epicatechin gallate, and (-)-epicatechin. A variation in the concentration profile of catechins was detected during the oxidation process. The chromatographic study demonstrated that (-)-gallocatechin, (-)- epigallocatechin, (+)-catechin, and (-)-catechin gallate exhibited the most radical scavenging.

  2. Geomorphic evolution of the San Luis Basin and Rio Grande in southern Colorado and northern New Mexico

    Science.gov (United States)

    Ruleman, Chester A.; Machette, Michael; Thompson, Ren A.; Miggins, Dan M; Goehring, Brent M; Paces, James B.

    2016-01-01

    The San Luis Basin encompasses the largest structural and hydrologic basin of the Rio Grande rift. On this field trip, we will examine the timing of transition of the San Luis Basin from hydrologically closed, aggrading subbasins to a continuous fluvial system that eroded the basin, formed the Rio Grande gorge, and ultimately, integrated the Rio Grande from Colorado to the Gulf of Mexico. Waning Pleistocene neotectonic activity and onset of major glacial episodes, in particular Marine Isotope Stages 11–2 (~420–14 ka), induced basin fill, spillover, and erosion of the southern San Luis Basin. The combined use of new geologic mapping, fluvial geomorphology, reinterpreted surficial geology of the Taos Plateau, pedogenic relative dating studies, 3He surface exposure dating of basalts, and U-series dating of pedogenic carbonate supports a sequence of events wherein pluvial Lake Alamosa in the northern San Luis Basin overflowed, and began to drain to the south across the closed Sunshine Valley–Costilla Plain region ≤400 ka. By ~200 ka, erosion had cut through topographic highs at Ute Mountain and the Red River fault zone, and began deep-canyon incision across the southern San Luis Basin. Previous studies indicate that prior to 200 ka, the present Rio Grande terminated into a large bolson complex in the vicinity of El Paso, Texas, and systematic, headward erosional processes had subtly integrated discontinuously connected basins along the eastern flank of the Rio Grande rift and southern Rocky Mountains. We propose that the integration of the entire San Luis Basin into the Rio Grande drainage system (~400–200 ka) was the critical event in the formation of the modern Rio Grande, integrating hinterland basins of the Rio Grande rift from El Paso, Texas, north to the San Luis Basin with the Gulf of Mexico. This event dramatically affected basins southeast of El Paso, Texas, across the Chisos Mountains and southeastern Basin and Range province, including the Rio

  3. 76 FR 80430 - Rio Tinto plc and Rio Tinto Limited; Notice of Application

    Science.gov (United States)

    2011-12-23

    ... plc and Rio Tinto Limited; Notice of Application December 19, 2011. AGENCY: Securities and Exchange Commission (``Commission''). ACTION: Notice of application under section 3(b)(2) and 45(a) of the Investment Company Act of 1940 (the ``Act''). SUMMARY: Summary of Application: Rio Tinto plc (``RTP'') and Rio Tinto...

  4. Anticoccidial efficacy of naringenin and a grapefruit peel extract in growing lambs naturally-infected with Eimeria spp.

    Science.gov (United States)

    Pérez-Fonseca, Agustín; Alcala-Canto, Yazmin; Salem, Abdelfattah Z M; Alberti-Navarro, Aldo B

    2016-12-15

    The current study aimed to determine the anti-Eimeria efficacy of an extract of grapefruit peels (GF) and commercial naringenin (NAR) in naturally-infected lambs, as well as the influence of these flavonoids on the oxidative status during ovine coccidiosis. Pharmacokinetic profiles were also determined. Extracts were administered per os to Eimeria naturally infected growing lambs during 90 consecutive days. The commercial anticoccidial drug toltrazuril (TTZ) was included in this trial as a standard. Twenty-four lambs were divided into four groups: NAR, lambs given a daily dose of 5mg of a commercial naringenin extract of 98% higher purity per kg body weight; GF, lambs that recived a daily dose of 5mg of ethanolic extract of grapefruit peels per kg body weight; TTZ, lambs treated with 20mg of toltrazuril/kg body weight on days 0 and 15 of the experiment; and CTRL, untreated lambs that received daily dose of 30ml of water. Daily doses of GF and NAR were dissolved in 30ml of water and orally given to animals; whereas toltrazuril was administered as a single dose of an undiluted suspension to lambs of the TTZ group. The CTRL group received 30ml of water; as well as the TTZ group for the period after the single dose administration. Fecal and serum samples were collected from all lambs. Anticoccidial efficacy was estimated by coprological techniques. Generation of nitric oxide levels and the antioxidant capacity of the experimental compounds were determined by the Griess and ABTS assays, respectively. The pharmacokinetic parameters of NAR and the GF extract were obtained. On day 30 post-ingestion, anticoccidial efficacy was 91.76% (NAR) and 89.65% (GF); whereas 99.63% of efficacy was achieved with TTZ 15days after treatment. NAR, GF and TTZ significantly reduced oxidative stress in infected animals. The mean daily weight gain for each group was 122g (NAR), 122g (GF), 143g (TTZ) and 98g (CTRL). Following the oral administration of NAR and GF, values in plasma approached

  5. Programa de controle do tabagismo do hospital universitário Cassiano Antônio de Moraes: perfil de usuários e funcionários

    Directory of Open Access Journals (Sweden)

    Lorena ALBERTASSE

    2013-09-01

    Full Text Available funcionários do Hospital Universitário Cassiano Antônio de Moraes, quanto a aspectos socioeconômicos e tabagísticos. Metodologia: Trata-se de um estudo descritivo e exploratório, conduzido sobre abordagem quantitativa. Resultados: Entre os usuários do serviço, 19,2% são fumantes e 24% ex-fumante. A faixa etária em que mais se fuma foi a de 20-39 anos (8,5%. 39,2% dos usuários fumantes possuem o Ensino Fundamental Incompleto e renda de até 2 salários mínimos (41,3%. A quantidade em anos que se fuma é maior naqueles que fumam há mais de 10 anos (42,3%. Entre os funcionários o número de fumantes foi de 12 (12,2%, sendo que 5 (41,6% fumam há mais de 20 anos; 66,7% tinham o Ensino Médio e 67,6% recebiam renda de 2-5 salários mínimos. Nos dois grupos estudados foi elevada à prevalência de fumantes que referiu o desejo de cessar o fumo (74% usuários, 83,3% funcionários, no entanto apenas uma pequena parcela já se submeteu a algum tipo de tratamento.

  6. Nos caminhos do pai: influências de Francisco Palmério na formação do escritor Mário Palmério

    Directory of Open Access Journals (Sweden)

    André Azevedo da Fonseca

    2011-12-01

    Full Text Available O artigo traça uma biografia de Francisco Palmério (1867-1947, pai do escritor mineiro Mário Palmério (1916-1996 – autor de Vila dos Confins (1956 e Chapadão do Bugre (1965. Através de fontes primárias e análise documental, a pesquisa desenvolve interpretações sobre as influências paternas de caráter moral, cultural, intelectual e profissional que marcaram a primeira geração da família Palmério no Brasil e, particularmente, condicionaram as experiências que mais tarde seriam ressignificadas na obra literária e na trajetória pessoal de Mário Palmério. Notamos que as permanentes viagens a trabalho do pai e as suas diversas atividades profissionais favoreceram uma consciência familiar das particularidades da região. Essa experiência favoreceu a criação de vínculos econômicos, políticos e afetivos com a cultura regional e estimulou nos filhos um profundo conhecimento histórico e geográfico do Oeste mineiro. Além disso, o pai parece ter exercido uma profunda influência sobre os filhos no que diz respeito ao gosto pela política regional. O artigo desenvolve a hipótese de que todas essas experiências foram elementos presentes na formação de Mário Palmério e, mais tarde, apareceriam de modo explícito em sua literatura marcada pela descrição da natureza, do cotidiano e das intrigas políticas regionalistas. Palavras-chave: Regionalismo; Literatura regionalista; Literatura mineira; Mário Palmério; Vila dos Confins; Chapadão do Bugre.

  7. The BDS iGMAS RIOS station at Observatório Nacional, Rio de Janeiro

    Science.gov (United States)

    Humberto Andrei, Alexandre; Song, Shuli; Junqueira, Selma; Beauvalet, Laurene

    2016-07-01

    GNSS navigation satellites are currently being developed by all major players in the science and technology scene, to compete with the GPS system. Because their applications span many different areas, from traffic and cargo control, to geodesy and seismic monitoring, it is required to assess the coherence between the different constellations. BDS is the GNSS system currently developed in China. Its first generation of satellites consisted of 3 geostationnary satellites allowing geolocalisation in China only. In addition to these satellites, other satellites have been launched in geostationnary and geosynchronous orbits, as well as satellites orbiting with a classical GNSS semi-major axis. With these additions, the BDS system possesses 19 operating satellites, and though the system is mostly efficient for geolocalisation in Asia, the satellites are also visible in other parts of the globe. In parallel to the development of the BDS constellation, China has launched the iGMAS (International GNSS Monitoring and Assessment Service) project to develop a global tracking network of multi-GNSS geodetic receivers. One of the goals of this project is to evaluate the efficiency of the BDS constellation as well as the efficiency of the receivers developed by the Chinese laboratories. As part of the Brazilian program COSBAN leaded by the Foreign Affairs Ministry to foster up the science and technology partnership with China, materialized by the collaboration between the Shanghai Astronomical Observatory/CAS and the Observatório Nacional/MCTI, in Rio de Janeiro. Through it the RIOS-iGMAS station was installed at Observatório Nacional, where the RJEP GNSS station already operates as part of the Brazilian reference system. Thus at the Observatório Nacional can be observed satellites from any constellation with both systems of reception, leading to a direct, efficient way to compare the results obtained for each network. In this communication we focus on the determination of the

  8. Abiquiu Dam and Reservoir, Rio Grande Basin, Rio Chama, New Mexico. Embankment Criteria and Performance Report.

    Science.gov (United States)

    1987-04-01

    EMBANKMENT CRITERIA AND PERFORMANCE REPORT PERTINENT DATA 1. General Data. LOCATION: Rio Arriba County, New Mexico, on the Rio Chama at river mile 33. PURPOSE...is located across the Rio Chama, approximately 30 miles upstream from its confluence with the Rio Grande, in Rio Arriba County, New Mexico. The dam is...6600- 4 i ’. 6600 65060- -60 6600- a + v6500s-go FA**v~w -6500 6300- 60 - ~ ~ ~ wo Ala filll------------------ EMBNKEN SECTION62 *LDN WOR SAFEL VAIE

  9. DIREITO AGRÁRIO E O TRATAMENTO DOS CONTRATOS AGRÁRIOS ATÍPICOS

    OpenAIRE

    Fabrício Pinto Weiblen; Marcelo Scherer da Silva; Tarso Wayhs Tech; José Fernando Lutz Coelho

    2012-01-01

    Aborda a necessidade de um tratamento adequado e diferenciado aos contratos agrários atípicos em face das complexas relações que se desenvolvem no meio rural atualmente. Apresenta ainda uma visão crítica a respeito das características e aplicabilidade da legislação agrária no cenário jurídico e propõe alternativas com o objetivo de uma prestação mais eficiente do Direito Agrário na área contratual.

  10. Adverse effects by artificial grapefruit seed extract products in patients on warfarin therapy.

    Science.gov (United States)

    Brandin, Helena; Myrberg, Olle; Rundlöf, Torgny; Arvidsson, Ann-Kristin; Brenning, Gunilla

    2007-06-01

    Grapefruit seed extract (GSE) is promoted as a natural product with antibacterial and antiviral properties. The aim of this study was to investigate the composition of some commercially available GSE products and evaluate their effect in vitro on two cytochrome P450 enzymes, CYP2C9 and CYP3A4. A couple on lifelong treatment with warfarin and continuous regular follow-ups took some drops of a GSE product for 3 days. The female patient experienced a minor subcutaneous haematoma 3 days later, and her international normalised ratio (INR) value was 7.9. This was reported to the Swedish Medical Products Agency (MPA) as a spontaneous post-marketing report concerning adverse drug reactions/interactions. The composition of the GSE products was determined by proton and carbon-13 nuclear magnetic resonance spectroscopy (NMR). The inhibitory effect of the GSE products on the cytochrome P450 enzymes was tested in an in vitro baculosome assay. The NMR analysis showed that all three investigated GSE products contained the synthetic preservative benzethonium chloride (BTC) in addition to glycerol and water. No authentic GSE extract was found in any of the three GSE products analysed. Furthermore, BTC was found to be a potent inhibitor of CYP3A4 and CYP2C9 activity in vitro. Our results suggest that BTC in the GSE products is responsible for the increase in the INR value in a patient on warfarin treatment.

  11. Effect of Grapefruit Seed Extract on Thermal Inactivation of Listeria monocytogenes during Sous-Vide Processing of Two Marinated Mexican Meat Entrées.

    Science.gov (United States)

    Valenzuela-Melendres, Martin; Peña-Ramos, E Aida; Juneja, Vijay K; Camou, Juan Pedro; Cumplido-Barbeitia, German

    2016-07-01

    D- and z-values for Listeria monocytogenes were obtained for two Mexican meat entrées: pork meat marinated in tomatillo (green tomato) sauce (PTS) and beef marinated in a red chili sauce (BRCS), with addition of 0, 200, and 800 ppm of grapefruit seed extract (GSE). Meat samples inoculated with L. monocytogenes were packaged in sterile bags, immersed in a water bath, and held at 55, 57.5, 60, and 62.5°C for different periods of time. Depending upon the temperature, D-values at 0 ppm of GSE ranged from 26.19 to 2.03 min in BRCS and 26.41 to 0.8 min in PTS. Adding 800 ppm of GSE to BRCS thermally treated at 55 and 62.5°C significantly decreased inactivation time by 35%. A reduction in time of 25.9, 10.6, and 40.1% at 55, 57.5, and 60°C, respectively, was observed in PTS with 800 ppm of GSE. The z-values of L. monocytogenes were not significantly affected by GSE addition; average z-values were 7.25 and 5.09°C for BRCS and PTS, respectively. Estimated thermal lethality for a 7-D log reduction of L. monocytogenes under commercial-size sous-vide conditions at a reference temperature of 55°C was reached at 78 and 71 min for BRCS without and with 800 ppm of GSE, respectively. For PTS, 7-D reduction was attained at 69 and 61 min without and with addition of 800 ppm of GSE, respectively. Supplementing both Mexican meat entrées (BRCS and PTS) with 800 ppm of GSE rendered L. monocytogenes cells more sensitive to the lethal effect of heat. The results of this study will assist the retail food industry in designing acceptance limits on critical control points pertaining to cooking regimes to effectively eliminate L. monocytogenes in BRCS and PTS sous-vide processed Mexican meat entrées.

  12. Carcinoma inflamatório mamário canino.

    OpenAIRE

    Gomes, Cristiano; Voll, Juliana; Ferreira, Kelly; Ferreira, Rafael Rodrigues; Oliveira, Luciana Oliveira de; Contesini, Emerson Antônio; Oliveira, Rosemari Teresinha de

    2006-01-01

    O carcinoma inflamatório mamário é um carcinoma anaplásico com características clínicas e histopatológicas como crescimento rápido, envolvimento difuso, eritema, calor e dor nas mamas, edema nos membros posteriores, extensa infiltração de células inflamatórias, células epiteliais malignas nos linfonodos regionais apresentando um péssimo prognóstico. O cão é a única espécie animal em que esta neoplasia ocorre espontaneamente, entretanto apresenta uma incidência bastante rara tanto em humanos q...

  13. Acesso a ambulatório pediátrico de um hospital universitário

    Directory of Open Access Journals (Sweden)

    Selma C. Franco

    1998-08-01

    Full Text Available INTRODUÇÃO: No Brasil verifica-se um descompasso entre o aumento das necessidades de atenção à saúde e de sua oferta. O Sistema Único de Saúde, cujas deretrizes preconizam a atenção universal e eqüânime, determina a relevância desta temática dentro do campo da avaliação dos serviços de saúde. Assim, foram estudados dois ambulatórios de pediatria de um hospital universitário, um geral e outro de uma subespecialiadade (pneumologia, comparando os usuários quanto ao acesso. MÉTODO: Foram aplicados 221 questionários entre clientes de ambos os ambulatórios de pediatria com o objetivo de se estudar e comparar variáveis socioeconômicas, procedência, acesso aos referidos ambulatórios e outros serviços de saúde. RESULTADOS: Evidenciou-se grande dificuldade de locomoção dos pacientes, a maioria dos quais são encaminhados por serviços de saúde locais. Dos pacientes atendidos 40% não receberam nenhum atendimento anteriormente à sua chegada ao hospital, fato que decorre principalmente de seu baixo nível socioeconômico, que os torna dependentes exclusivamente dos serviços públicos de saúde. A comparação entre os dois ambulatórios mostra que os pacientes do ambulatório de especialidade têm melhor nível socioeconômico e são menos dependentes dos serviços públicos, configurando desta forma uma situação de ineqüidade. CONCLUSÕES: É apontado o melhor nível socioeconômico dos usuários da especialidade bem como questões organizacionais do próprio serviço como os responsáveis pela iniqüidade verificada.

  14. Ovários policísticos: critérios hemodinâmicos

    OpenAIRE

    Ávila,Márcio Augusto Pinto de; Murta,Carlos Geraldo Viana

    2001-01-01

    O advento da ultra-sonografia endovaginal de alta resolução abriu novas áreas de pesquisa nos ovários policísticos. O conhecimento da hemodinâmica ovariana é fundamental para o entendimento do comportamento fisiopatológico dos ovários policísticos. Os autores tecem considerações sobre a possibilidade da utilização do Doppler colorido na melhor definição dos ovários policísticos. Os dados sugerem que o aumento da vascularidade e a diminuição da resistência dos vasos do estroma ovariano, assim ...

  15. Characterization of clay used for red ceramic fabrication; Caracterizacao de argila utilizada para fabricacao de ceramica vermelha

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, P.S.; Morais, A.S.C.; Caldas, T.C.C.; Monteiro, S.N.; Vieira, C.M.F. [Universidade Estadual do Norte Fluminense Darcy Ribeiro (LAMAV/UENF), Campos dos Goytacazes, RJ (Brazil). Laboratorio de Materiais Avancados; Ribeiro, M.M., E-mail: patriciasp_@hotmail.com [Instituto Federal Fluminense (IFF), Campos dos Goytacazes, RJ (Brazil)

    2011-07-01

    The objective of this work is to characterize a clay used in the red ceramics fabrication, from Campos dos Goytacazes north of the State of Rio de Janeiro. The clay was submitted for physical, chemical and mineralogical tests. The results showed that the clay has a high content of clay minerals with kaolinitic predominance, high loss on ignition and low flux oxides. It is recommended that this clay is mixed with non-plastic materials. (author)

  16. Determination of Fe and Al contamination by NAA at preparation of traditional Mexican food

    International Nuclear Information System (INIS)

    Arriola, S.H.; Cruz, M.M.

    2007-01-01

    A study was carried out using NAA to measure the concentration of Al and Fe leached from kitchen ware into some popular Mexican sauces and juices. These elements were measured in red and green hot sauces cooked in Fe, Al and clay pans compared to a stainless steel pan. Similarly Al was measured in orange and grapefruit juices obtained using an Al extractor compared to a plastic one. (author)

  17. Co-treatment with grapefruit juice inhibits while chronic administration activates intestinal P-glycoprotein-mediated drug efflux.

    Science.gov (United States)

    Panchagnula, R; Bansal, T; Varma, M V S; Kaul, C L

    2005-12-01

    P-Glycoprotein (P-gp) mediated efflux is recognized as a significant biochemical barrier affecting oral absorption for a number of drugs. Various conflicting reports have been published regarding the effects of grapefruit juice (GFJ) on P-gp-mediated drug efflux, in which GFJ has been shown both to inhibit and activate it. Hence, the present study adopted a two-way approach, involving both co-treatment and chronic administration. Bi-directional transport of paclitaxel (PCL) was carried out in the absence and presence of GFJ extract, in rat everted ileum sac. Further, the effect of chronic administration of GFJ to rats was characterized by permeability studies with indinavir (INDI). Co-treatment of GFJ extract at 100% concentration reduced the asymmetric transport of PCL (efflux ratio = 20.8) by increasing absorptive (A --> B) transport by 921% and reducing secretory (B --> A) transport by 41%. Further, GFJ showed a concentration dependent effect on PCL permeability. Imipramine, a passive permeability marker with absorptive permeability of 15.33 +/- 4.26 x 10(-6) cm/s showed no asymmetric transport and also no significant (P extract inhibited P-gp-mediated efflux in co-treatment, whereas chronic administration led to increased levels of P-gp expression, thus having a profound effect on intestinal absorption and GFJ-drug interactions in vivo.

  18. Economic evaluation of feedlot finished Red Angus young steers slaughtered with different weights

    OpenAIRE

    Restle, João; Pacheco, Paulo Santana; Costa, Eduardo Castro da; Freitas, Aline Kellermann de; Vaz, Fabiano Nunes; Brondani, Ivan Luiz; Fernandes, Juliano José de Resende

    2007-01-01

    Objetivou-se com este estudo avaliar economicamente a terminação em confinamento de novilhos Red Angus superjovens alimentados até atingirem os pesos de abate pretendidos de 340, 370, 400 e 430 kg (pesos reais obtidos: 340, 373, 401 e 434 kg). O número de dias necessários para atingir os respectivos pesos foi de 114, 144, 168 e 209 dias aos 12, 13, 14 e 15 meses de idade. Os animais foram alimentados com dieta contendo 13,26% de PB e relação volumoso (silagem de milho):concentrado de 56,21:43...

  19. Antimicrobial and physical-mechanical properties of agar-based films incorporated with grapefruit seed extract.

    Science.gov (United States)

    Kanmani, Paulraj; Rhim, Jong-Whan

    2014-02-15

    The use of synthetic petroleum based packaging films caused serious environmental problems due to their difficulty in recycling and poor biodegradability. Therefore, present study was aimed to develop natural biopolymer-based antimicrobial packaging films as an alternative for the synthetic packaging films. As a natural antimicrobial agent, grapefruit seed extract (GSE) has been incorporated into agar to prepare antimicrobial packaging film. The films with different concentrations of GSE were prepared by a solvent casting method and the resulting composite films were examined physically and mechanically. In addition, the films were characterized by FE-SEM, XRD, FT-IR and TGA. The incorporation of GSE caused increase in color, UV barrier, moisture content, water solubility and water vapor permeability, while decrease in surface hydrophobicity, tensile strength and elastic modulus of the films. As the concentration of GSE increased from 0.6 to 13.3 μg/mL, the physical and mechanical properties of the films were affected significantly. The addition of GSE changed film microstructure of the film, but did not influence the crystallinity of agar and thermal stability of the agar-based films. The agar/GSE films exhibited distinctive antimicrobial activity against three test food pathogens, such as Listeria monocytogenes, Bacillus cereus and Escherichia coli. These results suggest that agar/GSE films have potential to be used in an active food packaging systems for maintaining food safety and extending the shelf-life of the packaged food. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Rio responses in the Netherlands

    International Nuclear Information System (INIS)

    Bruggink, J.J.C.

    1994-01-01

    Three of the five agreements reached in Rio - the Rio Declaration, Agenda 21 and the Framework Convention on Climate Change - are briefly summarised from and energy perspective. The state of the art in the two national policy areas that are crucial for sustainable development, environmental policy and development cooperation, are then described. Some conclusions are drawn regarding the major bottlenecks and challenges for Dutch policies in the wake of Rio. 2 figs

  1. Riscos de cont?gio em tuberculose entre funcion?rios em um hospital universit?rio no munic?pio de Niter?i - Rio de Janeiro

    OpenAIRE

    Couto, Ingrid Ramos Reis

    2012-01-01

    Problema: O aparecimento de casos de adoecimentos por tuberculose entre os funcion?rios do HUAP. Objetivos: Analisar os fatores de risco para tuberculose e o perfil epidemiol?gico dos funcion?rios do HUAP/UFF com resultado da prova tubercul?nica ? 10 mm no per?odo de 2007 a junho de 2011; - Investigar os casos de adoecimento por tuberculose em funcion?rios do HUAP/UFF no per?odo de janeiro de 2004 a julho de 2011; - Identificar a poss?vel associa??o entre o perfil epidemiol?gico dos funcion?r...

  2. Em foco: sustentabilidade Rio 2016, Agosto 2015

    OpenAIRE

    2015-01-01

    Neste endereço, é possível encontrar o primeiro relatório de sustentabilidade do Rio 2016, "Abraçando Mudanças", bem como o Plano de Gestão de Sustentabilidade, o Relatório de Gestão de Pegada de Carbono e o Relatório de Impacto dos Jogos.

  3. Refractory oxides containing aluminium and barium Oxidos refratários contendo alumínio e bário

    Directory of Open Access Journals (Sweden)

    T. J. Davies

    1998-10-01

    Full Text Available Oxides containing aluminium and barium, optionally with chromium, are refractory with several possible industrial uses. A gel precursor of an oxide having the formula BaO.n(Al2xCr2yO3, where 1Oxidos contendo alumínio e bário, opcionalmente com crômio, são refratários com vários possíveis usos industriais. Foi preparado um gel precursor de um óxido de formula BaO.n(Al2xCr2yO3, com 1rio com uma solução de um sal de bário com solução de um sal de alumínio ou uma solução de um sal de alumínio e um sal de cromo III, formando então um gel que é queimado para se obter o óxido desejado. Filamentos podem ser estraídos duramente a formação do gel ou extrudados de um gel semi-rígido. Estudos de infravermelho com transformada de Fourier, difração de raios X e ressonância magnética nuclear com 27AL mostraram que o bário não é incorporado diretamente na estrutura do gel. Oxidos de alumínio e bário foram obtidos somente após liquefação de espécies de bário. Foi preparada uma mistura de pós adequada para queima para se obter um óxido de fórmula BaO.m[Al2x Cr2y O3] com 4,6rio, óxido de bário, carbonato de bário e mono-aluminato de bário, alumina e/ou alumina hidratada e óxido de cromo III, com quantidades relativas variando para se obter na queima valores desejados de m e de y. Corpos cerâmicos resistentes da fórmula BaO 6 Al2O3 (m=6 e y=0 foram preparados. Estudos de difração de raios X de óxidos de composições (n ou m=6 e y=0 sinterizados em alta temperatura mostraram que mono-aluminato de bário é uma fase intermediária de baixa temperatura. Cromo III reduz a temperatura necessária para formar um óxido de alumínio e bário. É feito um sumário de trabalhos anteriormente publicados.

  4. Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract.

    Science.gov (United States)

    Avula, B; Dentali, S; Khan, I A

    2007-08-01

    A HPLC method has been developed which permits the quantification of methyl paraben, benzethonium chloride and triclosan in various samples of grapefruit seed extract (GSE). The best results were obtained with a Phenomenex Gemini C18 column using gradient mobile phase of water (0.1% acetic acid) and acetonitrile (0.1% acetic acid) with a flow rate of 1.0 mL per minute. The detection wavelength was 254 nm for methyl paraben, and 275 nm for benzethonium chloride and triclosan. The main synthetic antimicrobial agent identified in commercial GSE samples was benzethonium chloride in concentrations from 0.29-21.84%. Positive ion electrospray MS of a commercial GSE sample showed a molecular ion at m/z 412 [M+], which matched that of a standard of benzethonium chloride. Triclosan was detected in two samples at 0.009 and 1.13%concentrations; while methyl paraben was not detected in the samples analyzed.

  5. Seeing red to being red: conserved genetic mechanism for red cone oil droplets and co-option for red coloration in birds and turtles.

    Science.gov (United States)

    Twyman, Hanlu; Valenzuela, Nicole; Literman, Robert; Andersson, Staffan; Mundy, Nicholas I

    2016-08-17

    Avian ketocarotenoid pigments occur in both the red retinal oil droplets that contribute to colour vision and bright red coloration used in signalling. Turtles are the only other tetrapods with red retinal oil droplets, and some also display red carotenoid-based coloration. Recently, the CYP2J19 gene was strongly implicated in ketocarotenoid synthesis in birds. Here, we investigate CYP2J19 evolution in relation to colour vision and red coloration in reptiles using genomic and expression data. We show that turtles, but not crocodiles or lepidosaurs, possess a CYP2J19 orthologue, which arose via gene duplication before turtles and archosaurs split, and which is strongly and specifically expressed in the ketocarotenoid-containing retina and red integument. We infer that CYP2J19 initially functioned in colour vision in archelosaurs and conclude that red ketocarotenoid-based coloration evolved independently in birds and turtles via gene regulatory changes of CYP2J19 Our results suggest that red oil droplets contributed to colour vision in dinosaurs and pterosaurs. © 2016 The Author(s).

  6. Late Miocene-Pleistocene evolution of a Rio Grande rift subbasin, Sunshine Valley-Costilla Plain, San Luis Basin, New Mexico and Colorado

    Science.gov (United States)

    Ruleman, C.A.; Thompson, R.A.; Shroba, R.R.; Anderson, M.; Drenth, B.J.; Rotzien, J.; Lyon, J.

    2013-01-01

    The Sunshine Valley-Costilla Plain, a structural subbasin of the greater San Luis Basin of the northern Rio Grande rift, is bounded to the north and south by the San Luis Hills and the Red River fault zone, respectively. Surficial mapping, neotectonic investigations, geochronology, and geophysics demonstrate that the structural, volcanic, and geomorphic evolution of the basin involves the intermingling of climatic cycles and spatially and temporally varying tectonic activity of the Rio Grande rift system. Tectonic activity has transferred between range-bounding and intrabasin faults creating relict landforms of higher tectonic-activity rates along the mountain-piedmont junction. Pliocene–Pleistocene average long-term slip rates along the southern Sangre de Cristo fault zone range between 0.1 and 0.2 mm/year with late Pleistocene slip rates approximately half (0.06 mm/year) of the longer Quaternary slip rate. During the late Pleistocene, climatic influences have been dominant over tectonic influences on mountain-front geomorphic processes. Geomorphic evidence suggests that this once-closed subbasin was integrated into the Rio Grande prior to the integration of the once-closed northern San Luis Basin, north of the San Luis Hills, Colorado; however, deep canyon incision, north of the Red River and south of the San Luis Hills, initiated relatively coeval to the integration of the northern San Luis Basin.Long-term projections of slip rates applied to a 1.6 km basin depth defined from geophysical modeling suggests that rifting initiated within this subbasin between 20 and 10 Ma. Geologic mapping and geophysical interpretations reveal a complex network of northwest-, northeast-, and north-south–trending faults. Northwest- and northeast-trending faults show dual polarity and are crosscut by north-south– trending faults. This structural model possibly provides an analog for how some intracontinental rift structures evolve through time.

  7. Fitossociologia de florestas de mangue plantadas e naturais no estuário do Rio das Ostras, Rio de Janeiro, Brasil

    Directory of Open Access Journals (Sweden)

    Elaine Bernini

    2013-10-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2014v27n1p37 A fitossociologia de florestas de mangue plantadas e naturais foi comparada no estuário do Rio das Ostras, Rio de Janeiro, Brasil. A amostragem da vegetação foi feita pelo método de parcelas, sendo registrado o diâmetro à altura do peito (DAP e a altura dos indivíduos > 1 m de altura. Os resultados indicaram que a floresta plantada apresenta menores valores de DAP médio e área basal, e maior densidade de troncos em relação à floresta natural. A distribuição de indivíduos por classes de altura e a distribuição de troncos por classes diamétricas mostraram que a floresta plantada é mais jovem. Laguncularia racemosa e Rhizophora mangle ocorreram em ambas as florestas, enquanto Avicennia schaueriana foi registrada apenas na floresta plantada. Laguncularia racemosa apresentou maior dominância e densidade relativa em todos os sítios analisados, provavelmente, por ser característica de locais com menor influência marinha e pelo fato do estuário ter sido alterado por perturbações antrópicas.

  8. Critérios de admissão e continuidade de cuidados em centros de atenção psicossocial, Rio de Janeiro, RJ Criterios de admisión y continuidad de cuidados en centros de atención psicosocial, Rio de Janeiro, Sureste de Brasil Criteria for admission and continuity of health care in psychosocial healthcare services, City of Rio de Janeiro, Southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Maria Tavares Cavalcanti

    2009-08-01

    ón psicosocial del municipio de Rio de Janeiro (Sureste de Brasil en 2006. Fueron sorteados 15 casos encaminados entre los pacientes admitidos para tratamiento en los seis meses anteriores al inicio de la investigación. Los criterios señalados por el equipo para la admisión del paciente para tratamiento o encaminamiento fueron analizados a partir de un itinerario estructurado. El análisis de la continuidad de cuidados se basó en investigación en prontuario, informaciones del equipo y de los propios pacientes y/o familiares seis meses posteriores a la absorción o encaminamiento del paciente. RESULTADOS: Los pacientes admitidos presentaban diagnóstico de psicosis (esquizofrenia, historia de internaciones previas, funcionamiento social pobre y red de apoyo pequeño y los pacientes encaminados presentaban trastornos ansiosos y depresivos, buena adhesión al tratamiento ambulatorio, buen funcionamiento social y presencia de red social. Con relación a la continuidad de cuidados, ocho pacientes en 27 tuvieron destino desconocido. Con relación a los encaminamientos, de los 13 pacientes encaminados a ambulatorios de la red, siete permanecieron en tratamiento, dos retornaron a los CAPS y cuatro tuvieron destino desconocido. CONCLUSIONES: Los centros admiten pacientes que se encajan en la definición de un trastorno mental severo y persistente. La continuidad de cuidado fue señalada como problema, probablemente debido a la dificultad de acompañar los pacientes en la comunidad.OBJECTIVE: To analyze the criteria used by teams for admission, referral and continuity of care among patients of the Centros de Atenção Psicossocial (CAPS - Psychosocial Care Centers. METHODS: A qualitative study with participatory evaluation was conducted in three psychosocial healthcare services of the city of Rio de Janeiro, Southeastern Brazil, in 2006. A total of 15 admitted cases and 15 referred cases were selected among the patients admitted for treatment during the six months that preceded the

  9. Análise da qualidade de água dos principais rios do município de Rio Negrinho (SC / Analysis of water quality of principal rivers in the Rio Negrinho city (SC

    Directory of Open Access Journals (Sweden)

    Simone Malutta

    2013-01-01

    Full Text Available As bacias hidrográficas do rio Preto e do rio Negrinho são as principais unidades do município de Rio Negrinho (SC. Nestas, há pontos de monitoramento de alguns parâmetros de qualidade de água realizados pelo Programa Intermunicipal da Água. O objetivo do presente trabalho foi realizar a análise da qualidade de água nesses vários pontos de monitoramento nos principais rios desse município. Para entender melhor os recursos hídricos da região em termos tanto de qualidade quanto de quantidade, foram feitas análises de correlações entre os dados monitorados de qualidade de água e os dados de vazão diários simulados pelo modelo SWAT. Não se encontrou correlação significativa entre os dados de vazão simulados pelo modelo SWAT e os dados de qualidade de água em todos os pontos analisados. Foi identificado que os rios Serrinhas e Banhado, os quais se localizam na bacia do rio Negrinho, apresentaram índices de qualidade de água inferiores aos demais rios estudados devido principalmente aos efluentes provindos da urbanização. Foi identificado que há medianas, vários outlier e valores extremos dos parâmetros de DBO e OD que ficaram muito acima da legislação vigente.

  10. CONSTRUÇÃO DE IDENTIDADE(S NA VELHICE: OS TERRITÓRIOS ENQUANTO MARCOS IDENTITÁRIOS

    Directory of Open Access Journals (Sweden)

    Marcia Regina Medeiros Veiga

    Full Text Available RESUMO Este artigo tem por objetivo refletir sobre o contributo específico dos territórios - a casa, a rua, o entorno - enquanto referência fundamental na construção identitária de pessoas idosas. Nossa base reflexiva foi construída a partir de observações e descrições do território conhecido como "Alta", no casco histórico de Coimbra, Portugal; entrevistas semiestruturadas, com 12 de seus residentes; e com notas de campo, sistematizadas num diário de bordo da pesquisa, construído para o efeito. A construção identitária de grande parte das pessoas idosas encontra-se profundamente ancorada nos territórios onde vivem, principalmente quando estas pessoas residem há muito tempo em um mesmo espaço geográfico, no qual vivenciam uma parte muito substantiva do seu cotidiano. Esta centralidade é, ainda, reforçada quando apresentam mobilidades reduzidas ou condicionadas, quer pelas dificuldades de acessibilidade dos próprios territórios, quer por limitações pessoais, iniciadas e/ou acentuadas na velhice.

  11. Deforestation near Rio Branco, Brazil

    Science.gov (United States)

    2001-01-01

    Settlement and deforestation surrounding the Brazilian town of Rio Branco are seen here in the striking 'herring bone' deforestation patterns that cut through the rainforest. Rio Brancois the capital of the Brazilian state of Acre and is situated near the border with northeastern Bolivia. The town is a center for the distribution of goods, including rubber, metals, medicinal plants, Brazil nuts and timber. Colonization projects in the region are supported by farming, logging activities, and extensive cattle ranching. Much of the surrounding terrain is of a poorly-draining clay hardpan soil, and heavy rainfall periodically converts parts of the forested region to swamp.The large overview image was acquired by the Multi-angle Imaging SpectroRadiometer's vertical-viewing (nadir) camera on July 28, 2000, and covers an area of 336 kilometers x 333 kilometers. A plume of smoke is visible north of the Rio Branco road, which roughly parallels the slender, twisting Rio Abuna. Most of the major rivers in the image provide reference points for state or international (Bolivia-Brazil) boundaries, and flow northeast to the Rio Madeira (east of the smoke plume). The border between Acre and the Bolivian department of Pando is marked by the Rio Abuna. Pando's southern boundary with the department of Beni is marked by the Rio Madre de Dios, the large river in the lower half of the image.The two higher-resolution inset images highlight a settled area north of the town of Rio Branco. These nadir views cover an area of 60 kilometers x 67 kilometers, and were acquired eleven months apart during Terra orbits 3251 and 8144. In the later image, more haze is present, possibly due to smoke from fires on that day. Comparing the two images provides a method of measuring the changes and expansion in the area of cleared land. One newly cleared patch is apparent near the middle of the later image, slightly off to the right. This polygon represents an area of about 16 square kilometers, or 4000

  12. Mammal assemblage of the agroecosystem constituents of the Várzea River Basin, Rio Grande do Sul, Brazil doi: 10.5007/2175-7925.2010v23n4p91

    Directory of Open Access Journals (Sweden)

    Felipe Bortolotto Peters

    2010-01-01

    Full Text Available We provide recent information on the richness of mammals along the agroecosystems of the Rio da Várzea Basin, Rio Grande do Sul, Brazil. We used different fi eld techniques to confi rm the occurrence of 46 mammal species in this area. Nine species are threatened in at least one of the three "red lists" at state, national and global levels. Adding the up-to-date results obtained in the fi eld to available data, mainly for conservation units, we present a richness of 85 species recorded for the basin. This number represents about 50% of mammals documented for Rio Grande do Sul state. The results suggest the importance of maintaining protected areas in altered regions, confi rming the relevance of inventories of local fauna as a fi rst approach to specifi c studies addressed to distribution, systematics, cytogenetics, physiology, population and community ecology.

  13. Application potential of grapefruit peel as dye sorbent: Kinetics, equilibrium and mechanism of crystal violet adsorption

    International Nuclear Information System (INIS)

    Saeed, Asma; Sharif, Mehwish; Iqbal, Muhammad

    2010-01-01

    This study reports the sorption of crystal violet (CV) dye by grapefruit peel (GFP), which has application potential in the remediation of dye-contaminated wastewaters using a solid waste generated by the citrus fruit juice industry. Batch adsorption of CV was conducted to evaluate the effect of initial pH, contact time, temperature, initial dye concentration, GFP adsorbent dose, and removal of the adsorbate CV dye from aqueous solution to understand the mechanism of sorption involved. Sorption equilibrium reached rapidly with 96% CV removal in 60 min. Fit of the sorption experimental data was tested on the pseudo-first and pseudo-second-order kinetics mathematical equations, which was noted to follow the pseudo-second-order kinetics better, with coefficient of correlation ≥0.992. The equilibrium process was well described by the Langmuir isotherm model, with maximum sorption capacity of 254.16 mg g -1 . The GFP was regenerated using 1 M NaOH, with up to 98.25% recovery of CV and could be reused as a dye sorbent in repeated cycles. GFP was also shown to be highly effective in removing CV from aqueous solution in continuous-flow fixed-bed column reactors. The study shows that GFP has the potential of application as an efficient sorbent for the removal of CV from aqueous solutions.

  14. Application potential of grapefruit peel as dye sorbent: kinetics, equilibrium and mechanism of crystal violet adsorption.

    Science.gov (United States)

    Saeed, Asma; Sharif, Mehwish; Iqbal, Muhammad

    2010-07-15

    This study reports the sorption of crystal violet (CV) dye by grapefruit peel (GFP), which has application potential in the remediation of dye-contaminated wastewaters using a solid waste generated by the citrus fruit juice industry. Batch adsorption of CV was conducted to evaluate the effect of initial pH, contact time, temperature, initial dye concentration, GFP adsorbent dose, and removal of the adsorbate CV dye from aqueous solution to understand the mechanism of sorption involved. Sorption equilibrium reached rapidly with 96% CV removal in 60 min. Fit of the sorption experimental data was tested on the pseudo-first and pseudo-second-order kinetics mathematical equations, which was noted to follow the pseudo-second-order kinetics better, with coefficient of correlation > or = 0.992. The equilibrium process was well described by the Langmuir isotherm model, with maximum sorption capacity of 254.16 mg g(-1). The GFP was regenerated using 1 M NaOH, with up to 98.25% recovery of CV and could be reused as a dye sorbent in repeated cycles. GFP was also shown to be highly effective in removing CV from aqueous solution in continuous-flow fixed-bed column reactors. The study shows that GFP has the potential of application as an efficient sorbent for the removal of CV from aqueous solutions. 2010 Elsevier B.V. All rights reserved.

  15. Application potential of grapefruit peel as dye sorbent: Kinetics, equilibrium and mechanism of crystal violet adsorption

    Energy Technology Data Exchange (ETDEWEB)

    Saeed, Asma, E-mail: asmadr@wol.net.pk [Environmental Biotechnology Group, Biotechnology and Food Research Centre, PCSIR Laboratories Complex, Ferozepur Road, Lahore 54600 (Pakistan); Sharif, Mehwish [School of Biological Sciences, University of the Punjab, Lahore 54590 (Pakistan); Iqbal, Muhammad [Environmental Biotechnology Group, Biotechnology and Food Research Centre, PCSIR Laboratories Complex, Ferozepur Road, Lahore 54600 (Pakistan)

    2010-07-15

    This study reports the sorption of crystal violet (CV) dye by grapefruit peel (GFP), which has application potential in the remediation of dye-contaminated wastewaters using a solid waste generated by the citrus fruit juice industry. Batch adsorption of CV was conducted to evaluate the effect of initial pH, contact time, temperature, initial dye concentration, GFP adsorbent dose, and removal of the adsorbate CV dye from aqueous solution to understand the mechanism of sorption involved. Sorption equilibrium reached rapidly with 96% CV removal in 60 min. Fit of the sorption experimental data was tested on the pseudo-first and pseudo-second-order kinetics mathematical equations, which was noted to follow the pseudo-second-order kinetics better, with coefficient of correlation {>=}0.992. The equilibrium process was well described by the Langmuir isotherm model, with maximum sorption capacity of 254.16 mg g{sup -1}. The GFP was regenerated using 1 M NaOH, with up to 98.25% recovery of CV and could be reused as a dye sorbent in repeated cycles. GFP was also shown to be highly effective in removing CV from aqueous solution in continuous-flow fixed-bed column reactors. The study shows that GFP has the potential of application as an efficient sorbent for the removal of CV from aqueous solutions.

  16. Grapefruit Derived Flavonoid Naringin Improves Ketoacidosis and Lipid Peroxidation in Type 1 Diabetes Rat Model.

    Directory of Open Access Journals (Sweden)

    Alfred N Murunga

    Full Text Available Hypoglycemic effects of grapefruit juice are well known but the effects of naringin, its main flavonoid on glucose intolerance and metabolic complications in type 1 diabetes are not known.To investigate the effects of naringin on glucose intolerance, oxidative stress and ketonemia in type 1 diabetic rats.Sprague-Dawley rats divided into 5 groups (n = 7 were orally treated daily with 3.0 ml/kg body weight (BW/day of distilled water (group 1 or 50 mg/kg BW of naringin (groups 2 and 4, respectively. Groups 3, 4 and 5 were given a single intra-peritoneal injection of 60 mg/kg BW of streptozotocin to induce diabetes. Group 3 was further treated with subcutaneous insulin (4.0 IU/kg BW twice daily, respectively.Stretozotocin (STZ only-treated groups exhibited hyperglycemia, polydipsia, polyuria, weight loss, glucose intolerance, low fasting plasma insulin and reduced hepatic glycogen content compared to the control group. Furthermore they had significantly elevated Malondialdehyde (MDA, acetoacetate, β-hydroxybutyrate, anion gap and significantly reduced blood pH and plasma bicarbonate compared to the control group. Naringin treatment significantly improved Fasting Plasma Insulin (FPI, hepatic glycogen content, malondialdehyde, β-hydroxybutyrate, acetoacetate, bicarbonate, blood pH and anion gap but not Fasting Blood Glucose (FBG compared to the STZ only-treated group.Naringin is not hypoglycemic but ameliorates ketoacidosis and oxidative stress. Naringin supplements could therefore mitigate complications of diabetic ketoacidosis.

  17. TERRITÓRIOS E FRONTEIRAS AMAZÔNICAS

    OpenAIRE

    Nogueira, Ricardo José Batista

    2014-01-01

    O texto apresenta uma discussão sobre a diversidade de territórios e fronteiras na Amazônia. Demonstra as diferenças entre fronteiras políticas e econômicas e a mobilidade no interior destes territórios. Aponta ainda que a criação de novos territórios - ecológicos e étnicos - instituiu novas fronteiras às populações rurais.

  18. Sulfato de bário versus carbonato de bário: um trágico equívoco de solubilidade

    OpenAIRE

    NEVES, Eduardo Almeida; NEVES, Regina Maria de Almeida

    2004-01-01

    Envenenamento seguido de morte de pessoas que ingeriram um sulfato de bário preparado em laboratório farmacêutico (em exames de Raios X), foram vítimas de produto contendo alguma porcentagem de carbonato de bário como contaminante. Tratamento por equilíbrio químico dos dados de solubilidade dos precipitados nas condições de acidez estomacal mostrou que a presença do carbonato de bário causa um aumento de solubilidade de 19200 vezes em íons de bário, em comparação com a esperada pelo sulfat...

  19. Inquiring into Red/Red Inquiring

    Directory of Open Access Journals (Sweden)

    Ken Gale

    2013-05-01

    Full Text Available This layered account of an inquiry into ‘red’ emerged out of a collective biography workshop. In the middle of the Wiltshire countryside, an international and interdisciplinary group of scholars gathered together to write and make other things and marks on paper that asked questions of, and into, the spaces between words, people, things and their environments. We did not set out to workshop or write into or paint ‘red’ but, rather, it was red that slipped in, uninvited, and painted and wrote us. Red arose as a blush or a stain seeping amongst us that became referenced obliquely by material objects, metaphors and fairytales. The stain spread, became noticeable through our weekend together and beyond it, creating another (bright red artery vein of connection to write with.

  20. Rock in Rio: forever young

    Directory of Open Access Journals (Sweden)

    Ricardo Ferreira Freitas

    2014-12-01

    Full Text Available The purpose of this article is to discuss the role of Rock in Rio: The Musical, as herald of megafestival Rock in Rio. Driven by the success that musicals have reached in Brazil, we believe that the design of this spectacle of music, dance and staging renews the brand of the rock festival, once it adds the force of young and healthy bodies to its concept. Moreover, the musical provides Rock in Rio with some distance from the controversal trilogy of sex, drugs and rock and roll, a strong mark of past festivals around the world. Thus, the musical expands the possibilities of growth for the brand.

  1. Comportamento aleatório: algumas considerações

    Directory of Open Access Journals (Sweden)

    Barba Lourenço de Souza

    2000-01-01

    Full Text Available Este estudo defende que o comportamento aleatório pode tornar-se legítimo objeto de estudo de uma ciência do comportamento. Analisamos inicialmente algumas considerações que B. F. Skinner formulou sobre o comportamento aleatório em suas Contingências do Reforço. Segundo Skinner (1969/1975, o comportamento aleatório "não apresenta interesse como processo de comportamento". Apresentamos uma rigorosa definição de "comportamento aleatório". Sustentamos que o comportamento aleatório pode constituir objeto de análise funcional, examinando alguns estudos empíricos que se têm conduzido sobre o comportamento aleatório. Apresentamos ainda algumas dificuldades empíricas e teóricas que podem afetar as investigações nessa área. Concluímos que o comportamento aleatório é um fascinante e importante tópico para uma completa ciência do comportamento.

  2. An Update on the Health Effects of Tomato Lycopene

    OpenAIRE

    Story, Erica N.; Kopec, Rachel E.; Schwartz, Steven J.; Harris, G. Keith

    2010-01-01

    Lycopene is a non-provitamin A carotenoid that is responsible for the red to pink colors seen in tomatoes, pink grapefruit, and other foods. Processed tomato products are the primary dietary lycopene source in the United States. Unlike many other natural compounds, lycopene is generally stable to processing when present in the plant tissue matrix. Recently, lycopene has also been studied in relation to its potential health effects. Although promising data from epidemiological, as well as cell...

  3. 7X performance results - final report : ASCI Red vs Red Storm.

    Energy Technology Data Exchange (ETDEWEB)

    Dinge, Dennis C. (Cray Inc., Albuquerque, NM); Davis, Michael E. (Cray Inc., Albuquerque, NM); Haskell, Karen H.; Ballance, Robert A.; Gardiner, Thomas Anthony; Stevenson, Joel O.; Noe, John P.

    2011-04-01

    The goal of the 7X performance testing was to assure Sandia National Laboratories, Cray Inc., and the Department of Energy that Red Storm would achieve its performance requirements which were defined as a comparison between ASCI Red and Red Storm. Our approach was to identify one or more problems for each application in the 7X suite, run those problems at multiple processor sizes in the capability computing range, and compare the results between ASCI Red and Red Storm. The first part of this report describes the two computer systems, the applications in the 7X suite, the test problems, and the results of the performance tests on ASCI Red and Red Storm. During the course of the testing on Red Storm, we had the opportunity to run the test problems in both single-core mode and dual-core mode and the second part of this report describes those results. Finally, we reflect on lessons learned in undertaking a major head-to-head benchmark comparison.

  4. Inventário de Emissões de Gases de Efeito Estufa no Campus Gávea da PUC-Rio

    Directory of Open Access Journals (Sweden)

    João Paulo Andrade F. de Carvalho

    Full Text Available RESUMO O presente trabalho apresenta resultados preliminares de um inventário de emissões de gases de efeito estufa (GEE elaborado para o campus da PUC-Rio, situado no bairro da Gávea, zona sul da cidade do Rio de Janeiro. Foram identificadas emissões de GEE nos escopos 1 (combustão estacionária e móvel, emissões fugitivas, escopo 2 (consumo de energia elétrica e escopo 3 (transporte, viagens, geração e descarte de resíduos sólidos, seguindo metodologias recomendadas pelo Programa Brasileiro GHG Protocol. Dentre as fontes de emissão, a mais difícil de quantificar foi justamente a principal geradora, relacionada com os deslocamentos entre o campus e as residências dos 20 mil potenciais frequentadores diários da PUC-Rio durante 2011.

  5. Mobilidade do ametryn em solos da região semiárida do Rio Grande do Norte Ametryn mobility in soils of Rio Grande do Norte semiarid region

    Directory of Open Access Journals (Sweden)

    F.C.L. Freitas

    2012-09-01

    profundidade. O método do bioensaio com pepino como planta indicadora pode ser utilizado em estudos de lixiviação desse herbicida, em substituição ao método cromatográfico.This work aimed to evaluate ametryn mobility in four types of soils, three from the semiarid region of the state of Rio Grande do Norte (Cambisol ; Fluvic Neosol; Latosolic Dystrophic Red-Yellow Argisol and one from the state of Minas Gerais (Red-Yellow Latosol. Ametryn mobility was evaluated using PVC columns of 10 cm in diameter and 50 cm long. The experiment was conducted in a split-plot in a completely randomized design with four replications. The plots were composed by the columns, filled with the four types of soils and the subplots by 10 depths at intervals of 5 cm (0-5, 5-10, 10-15, 15-20, 20-25, 25-30 , 30-35, 35-40, 40-45 and 45-50 cm. Ametryn was applied on top of the columns (4 kg ha-1 and, 12 hours later, rainfall was simulated at the intensity of 60 mm. After 72 hours of simulated rain, the columns were placed in a horizontal position and opened longitudinally, divided into sections of 5.0 cm. At the center of each section, soil samples were collected for subsequent herbicide extraction and quantification through analysis by liquid chromatography (HPLC. Five seeds of cucumber (Cucumis sativus were sown as bio-indicators of the presence of the herbicide. Ametryn mobility at the columns was influenced by the physical and chemical characteristics of the soil,(soil texture, organic matter, and pH. The Rio Grande do Norte semiarid region soils had higher ametryn mobility potential, being detected at up to 25, 20, and 15 cm depth in Latosolic Dystrophic Red- Yellow Argisol, Cambisol, and Fluvic Neosol, respectively. Ametryn mobility was restricted to 5 cm depth in the Red Yellow Latosol, with higher organic matter content and pH 4.7. The bioassay method was more efficient to confirm ametryn leaching than liquid chromatography.

  6. Tratamento de esgoto sanitário em sistemas alagados construídos cultivados com lírio-amarelo

    OpenAIRE

    Prata,Renata C. C.; Matos,Antonio T. de; Cecon,Paulo R.; Monaco,Paola A. V. Lo; Pimenta,Leonardo A.

    2013-01-01

    Neste artigo, avaliou-se a eficiência de quatro sistemas alagados construídos (SACs) no tratamento de esgoto sanitário após ser submetido a tratamento preliminar e, no caso de alguns SACs, a tratamento primário (tanque séptico). Os SACs foram cultivados com lírio-amarelo (Hemerocallis flava), tendo a brita #0 como meio suporte, e submetidos às taxas de carregamento orgânico (TCO) de esgoto sanitário, em termos de DBO (kg ha-1 d-1), de 44; 98; 230 e 395 kg ha-1 d-1 e tempos de detenção hidrául...

  7. Mesohabitats, fish assemblage composition, and mesohabitat use of the Rio Grande silvery minnow over a range of seasonal flow regimes in the Rio Grande/Rio Bravo del Norte, in and near Big Bend National Park, Texas, 2010-11

    Science.gov (United States)

    Moring, J. Bruce; Braun, Christopher L.; Pearson, Daniel K.

    2014-01-01

    In 2010–11, the U.S. Geological Survey (USGS), in cooperation with the U.S. Fish and Wildlife Service, evaluated the physical characteristics and fish assemblage composition of mapped river mesohabitats at four sites on the Rio Grande/Rio Bravo del Norte (hereinafter Rio Grande) in and near Big Bend National Park, Texas. The four sites used for the river habitat study were colocated with sites where the U.S. Fish and Wildlife Service has implemented an experimental reintroduction of the Rio Grande silvery minnow (Hybognathus amarus), a federally listed endangered species, into part of the historical range of this species. The four sites from upstream to downstream are USGS station 08374340 Rio Grande at Contrabando Canyon near Lajitas, Tex. (hereinafter the Contrabando site), USGS station 290956103363600 Rio Grande at Santa Elena Canyon, Big Bend National Park, Tex. (hereinafter the Santa Elena site), USGS station 291046102573900 Rio Grande near Ranger Station at Rio Grande Village, Tex. (hereinafter the Rio Grande Village site), and USGS station 292354102491100 Rio Grande above Stillwell Crossing near Big Bend National Park, Tex. (hereinafter the Stillwell Crossing site).

  8. Itinerário dos usuários de medicamentos via judicial no estado do Amazonas, Brasil

    Directory of Open Access Journals (Sweden)

    Marselle Nobre de Carvalho

    2014-12-01

    Full Text Available Este artigo teve como objetivo analisar o itinerário dos usuários que tiveram acesso a medicamentos via judicial no estado do Amazonas, Brasil. Trata-se de estudo qualitativo, prospectivo, baseado em dados coletados por meio de entrevistas semiestruturadas com usuários que receberam medicamentos via mandado judicial. A judicialização na saúde mostrou-se um fator agregador ao reconhecimento dos direitos e da cidadania pelos usuários que, na sua trajetória de vida, acabaram adquirindo um grande aprendizado sobre formas de enfrentar a falta de acesso aos medicamentos. Conclui-se que a relação entre o sujeito e o Estado permanece desigual, e o direito à saúde se deu na dimensão individual e restritiva, desconsiderando a dimensão coletiva e a concepção de cidadania.

  9. Albuquerque/Middle Rio Grande Urban Waters Viewer

    Science.gov (United States)

    These data have been compiled in support of the Middle Rio Grande/Albuquerque Urban Waters Partnership for the region including Albuquerque, New Mexico.The Middle Rio Grande/Albuquerque Urban Waters Federal Partnership is co-chaired by the U.S. Dept. of Housing and Urban Development and the U.S. Environmental Protection Agency. There are also a number of other federal agencies engaged in projects with Tribal, State, and local officials, and community stakeholders. Like many western river ecosystems, the Middle Rio Grande faces numerous challenges in balancing competing needs within a finite water supply and other resource constrains. Historical practices by our ancestors and immigrants to the Middle Rio Grande have established the conditions that we have inherited. Long-term drought exacerbated by climate change is changing conditions that affect natural and human communities as we strive to improve our precious Rio Grande.The Middle Rio Grande/Albuquerque Urban Waters Federal Partnership will reconnect our urban communities, particularly those that are overburdened or economically distressed, with the waterway by improving coordination among federal agencies and collaborating with community-led revitalization efforts. Our projects will improve our community water systems and promote their economic, environmental and social benefits. Specifically, the Middle Rio Grande/Albuquerque Urban Waters Federal Partnership will support the development of the Valle de Oro

  10. O Barão do Rio Branco no Itamaraty (1902-1912 Baron of Rio Branco in Itamaraty (1902-1912

    Directory of Open Access Journals (Sweden)

    Clodoaldo Bueno

    2012-12-01

    Full Text Available Os cem anos do fim da gestão do Barão do Rio Branco no Ministério das Relações Exteriores do Brasil coincidem com um momento politicamente propício para se revisitar o legado do patrono da diplomacia brasileira, em especial o referente aos Estados Unidos e ao Prata, os dois principais eixos das relações externas do País. Examinam-se o teor das relações com a potência hegemônica do hemisfério e o caráter oscilante daquelas com a Argentina. A partir de fontes primárias e bibliográficas, o autor procura demonstrar que Rio Branco, além do fechamento dos limites do território nacional, firmou tendências e procedimentos que se incorporaram à tradição da diplomacia brasileira, analisando, para isso, a função do alinhamento Rio de Janeiro-Washington no conjunto da política externa do chanceler e o padrão das relações com o governo argentino, fatores que influenciaram seus movimentos no entorno geográfico. A política de prestígio desenvolvida por Rio Branco decorreu da aspiração em diferenciar seu país do conjunto de nações do segmento sul do hemisfério, identificadas com convulsões políticas e insolvência financeira.The hundredth anniversary of the end of Baron of Rio Branco's administration at the Brazilian Ministry of External Relations matches with a politically favorable moment for examining the legacy of the patron of the Brazilian Diplomacy, especially concerning the United States and the Río de la Plata, the two main axes of Brazilian foreign relations. It examines the content of the relations with the hemisphere's hegemonic power and the oscillating nature of the relations with Argentina. Using primary and bibliographic sources, the author aims to demonstrate that, in addition to accomplishing the process of delimiting the country's boundaries, Rio Branco established trends and procedures which were incorporated into the Brazilian Diplomatic Tradition. For this, the author analyzes the role the Rio de

  11. Avaliação sazonal do rendimento de óleo essencial em espécies de menta Seasonal evaluation of essential oil yield of mint species

    Directory of Open Access Journals (Sweden)

    Cícero Deschamps

    2008-06-01

    Full Text Available O gênero Mentha compreende diversas espécies de interesse econômico por causa da produção de óleos essenciais. Recentemente, foram introduzidos no Brasil novos materiais genéticos para avaliação da adaptação em relação ao potencial de rendimento e composição do óleo essencial. No presente trabalho, foram comparadas essas características em cultivares das espécies Mentha x piperita L. (cv. Grapefruit Mint e cv. Persian Mint Field, M. suaveolens Ehrh. (cv. Hillarys Sweet Lemon Mint, M. spicata L. (cv. Mentol Mint, M. aquatica L. (cv. Common Mint e M. arvensis L. (cv. Banana Mint, durante o verão e inverno em Curitiba (PR. O rendimento médio das cultivares no verão foi aproximadamente o dobro do rendimento observado no inverno. Duas cultivares de Mentha x piperita L. (cv. Persina Mint Field e cv. Grapefruit Mint apresentaram maior rendimento de óleo essencial no verão e inverno, sendo que as demais não diferiram entre si. A análise da composição do óleo essencial indicou grande variação nessas cultivares, sendo observada a presença de linalol, como constituinte majoritário na cv. Grapefruit Mint e a-felandren-8-ol e cis-ocimeno na cv. Persian Mint Field.The genus Mentha includes many species of economic interest due the essential oil production. Recently new genetic materials were introduced in Brazil to evaluate the adaptation related to essential oil yield and composition. In the present work, these characteristics were compared in six cultivars of the species Mentha x piperita L. (cv. Grapefruit Mint e cv. Persian Mint Field, M. suaveolens Ehrh (cv. Hillarys Sweet Lemon Mint, M. spicata L. (cv. Mentol Mint, M. aquatica L. (cv. Common Mint and M. arvensis L. (cv. Banana Mint during summer and winter in Curitiba (PR. The average of essential oil yield obtained from samples collected during the summer was approximately two fold the observed during the winter. Two cultivars of Mentha piperita (cv. Persian Mint Field

  12. Adsorption of procion red and congo red dyes using microalgae Spirulina sp

    Directory of Open Access Journals (Sweden)

    Risfidian Mohadi

    2017-10-01

    Full Text Available Adsorption of procion red and congo red dyes using microalgae Spirulina sp was conducted. Spirulina sp was obtained by cultivation and production in laboratory scale. Spirulina sp was used as adsorbent for adsorption of dyes. Adsorption process was studied by kinetic and thermodynamic in order to know the adsorption phenomena. The results showed that kinetically congo red is reactive than procion red on Spirulina sp. On the other hand, thermodynamically procion red was stable than congo red on Spirulina sp which was indicated by adsorption capacity, enthalpy, and entropy.

  13. Consumption of clarified grapefruit juice ameliorates high-fat diet induced insulin resistance and weight gain in mice.

    Science.gov (United States)

    Chudnovskiy, Rostislav; Thompson, Airlia; Tharp, Kevin; Hellerstein, Marc; Napoli, Joseph L; Stahl, Andreas

    2014-01-01

    To determine the metabolic effects of grapefruit juice consumption we established a model in which C57Bl/6 mice drank 25-50% sweetened GFJ, clarified of larger insoluble particles by centrifugation (cGFJ), ad libitum as their sole source of liquid or isocaloric and sweetened water. cGFJ and control groups consumed similar amounts of liquids and calories. Mice fed a high-fat diet and cGFJ experienced a 18.4% decrease in weight, a 13-17% decrease in fasting blood glucose, a three-fold decrease in fasting serum insulin, and a 38% decrease in liver triacylglycerol values, compared to controls. Mice fed a low-fat diet that drank cGFJ experienced a two-fold decrease in fasting insulin, but not the other outcomes observed with the high-fat diet. cGFJ consumption decreased blood glucose to a similar extent as the commonly used anti-diabetic drug metformin. Introduction of cGFJ after onset of diet-induced obesity also reduced weight and blood glucose. A bioactive compound in cGFJ, naringin, reduced blood glucose and improved insulin tolerance, but did not ameliorate weight gain. These data from a well-controlled animal study indicate that GFJ contains more than one health-promoting neutraceutical, and warrant further studies of GFJ effects in the context of obesity and/or the western diet.

  14. Effects of Grapefruit Seed Extract on Oxidative Stability and Quality Properties of Cured Chicken Breast.

    Science.gov (United States)

    Kang, Su-Tae; Son, Hee-Kyoung; Lee, Hyun-Joo; Choi, Jung-Seok; Choi, Yang-Il; Lee, Jae-Joon

    2017-01-01

    This study investigated the antioxidative and functional effects of a curing agent containing grapefruit seed extract (GSE) on the quality and storage characteristics of chicken breast. The total polyphenol and total flavonoid contents of GSE were 45.06 mg/g and 36.06 mg/g, respectively. The IC 50 value of 2,2-diphenyl-1-picrylhydrazyl hydroxyl scavenging of GSE was 333.33 μg/mL. The chicken breast comprised six groups: no-treatment (N), 0.2% ascorbic acid + 70 ppm sodium nitrite (C), 0.05% GSE (G0.05), 0.1% GSE (G0.1), 0.3% GSE (G0.3), and 0.5% GSE (G0.5). The pH and cooking loss of cured chicken breast decreased with increasing GSE levels, and the water holding capacity increased with increasing GSE levels. The hardness and chewiness of GSE-treated chicken breast were higher than those of N and C. Hunter's L and a color values increased significantly after GSE addition. Moreover, 0.1% GSE (G0.1) increased the flavor and total acceptability scores. The 2-thiobarbituric acid and volatile basic nitrogen values of the 0.5% GSE group decreased significantly compared with those of C group. Total microbial counts of GSE-treated chicken breast were higher than those of C, but that lower than those of N. Adding GSE to chicken breast delayed lipid peroxidation and had antimicrobial effects during cold storage. GSE improved shelf life and palatability; therefore, it could be used as a natural antioxidant and functional curing agent ingredient in meat products.

  15. Romantic red: red enhances men's attraction to women.

    Science.gov (United States)

    Elliot, Andrew J; Niesta, Daniela

    2008-11-01

    In many nonhuman primates, the color red enhances males' attraction to females. In 5 experiments, the authors demonstrate a parallel effect in humans: Red, relative to other achromatic and chromatic colors, leads men to view women as more attractive and more sexually desirable. Men seem unaware of this red effect, and red does not influence women's perceptions of the attractiveness of other women, nor men's perceptions of women's overall likeability, kindness, or intelligence. The findings have clear practical implications for men and women in the mating game and, perhaps, for fashion consultants, product designers, and marketers. Furthermore, the findings document the value of extending research on signal coloration to humans and of considering color as something of a common language, both within and across species. (c) 2008 APA, all rights reserved.

  16. Record of Pleopis schmackeri (Poppe Branchiopoda in Rio das Ostras, Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Wanda Maria Monteiro-Ribas

    2013-03-01

    Full Text Available The paper describes the first occurrence of Pleopis schmackeri (Poppe, 1889 (Branchiopoda, Onychopoda in Rio das Ostras, Rio de Janeiro, Brazil is described. This marine cladoceran species occurred in zooplanktonic samples obtained on July, 2003 with mean density of 10 ind.m-3. Its presence may be related to two hypotheses, due to ballast water and through the Brazilian current, which gets closer to the coast Winter.

  17. Evidence for host plant preference by Iphiseiodes quadripilis (Acari: Phytoseiidae) on Citrus.

    Science.gov (United States)

    Villanueva, Raul T; Childers, Carl C

    2006-01-01

    In this study, we present field and laboratory evidence on the preference of Iphiseiodes quadripilis (Banks) for grapefruit (Citrus paradisi Macfadyen) leaves compared with sweet orange (Citrus sinensis (L.) Osbeck) leaves. This preference was confirmed in four orchards whether leaf samples were taken from either border trees of contiguous grapefruit or sweet orange or interior row trees with both citrus species in adjacent rows. Iphiseiodes quadripilis was most abundant in grapefruit trees in spite of the greater abundance of the Texas citrus mite, Eutetranychus banksi (McGregor) (Acari: Tetranychidae) in sweet orange trees. Similar preference responses were observed in laboratory tests using a Y-tube olfactometer whether I. quadripilis were collected from sweet orange or grapefruit. Iphiseiodes quadripilis collected from grapefruit trees showed significant preference for grapefruit over sweet orange leaves in contact choice tests using an arena of alternating leaf strips (12 mm long x 2 mm wide) of sweet orange and grapefruit. However, I. quadripilis collected from sweet orange trees did not show preference for either grapefruit or sweet orange leaves. Based on these results, grapefruit leaves foster some unknown factor or factors that retain I. quadripilis in greater numbers compared with sweet orange leaves.

  18. Phenolic compounds in Merlot wines from two wine regions of Rio Grande do Sul, Brazil

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    Carlos Eugenio Daudt

    2013-06-01

    Full Text Available In Brazil, the grape and wine production takes place mainly in the state of Rio Grande do Sul, and the region "Serra" is known as the traditional wine region. In the last years, new areas have emerged, with emphasis for the Campanha region; the red wines from this region have low acidity, little color intensity, and are wines to drink while young, even when produced from grape varieties such as Merlot and Cabernet Sauvignon. The objective of this study was to evaluate the influence of different maceration types on the phenolic compounds of Merlot wines made with grapes produced in two regions of Rio Grande do Sul, Serra and Campanha, as well as to identify the key differences between the wines produced. The localization of the vineyards seems to have more influence on the wine characteristics than the maceration type. The color due copigmentation was an important aspect in the wines made with short maceration. The effect of extended maceration was different than the expected for the Campanha region wines; the extended maceration increased the extraction of tannins resulting in greater color intensity and a greater amount of anthocyanins. The pH control seems to be a key factor for the Campanha region wines.

  19. Aspectos de leiaute e de design de lojas de vestuário: estudo da percepção dos usuários

    Directory of Open Access Journals (Sweden)

    Márcia Machado França

    2017-05-01

    Full Text Available Esta pesquisa tem como objetivo analisar o leiaute e os elementos do design tais como: iluminação, mobiliário presentes nos espaços da rede de varejo do vestuário do modelo fast fashion e a influência destes na percepção dos usuários. Foram realizadas entrevistas semiestruturadas e observação não participante com os usuários destes espaços, buscando informações da interação deles com o ambiente. A revisão da literatura abordou os seguintes tópicos: design de lojas, modelo fast fashion, varejo de moda e usuários do vestuário. Por meio dos dados da pesquisa será possível identificar possíveis obstáculos do ambiente de loja para poder gerar melhores alternativas deste espaço ao usuário. Esta pesquisa aponta para abertura de novas oportunidades de exploração do design de lojas nos segmentos de varejo, por meio dos levantamentos obtidos nesta pesquisa.

  20. Teorias do abuso no planejamento tributário

    OpenAIRE

    Luís Flávio Neto

    2011-01-01

    O presente estudo analisa teorias do abuso no planejamento tributário. Inicialmente, busca-se definir e diferenciar planejamento tributário, planejamento tributário abusivo e evasão fiscal, partindo-se da premissa de que compete a cada Estado estabelecer, de forma peculiar, quais os critérios devem ser adotados para a identificação dessas figuras em seu ordenamento jurídico. Analisam-se os princípios constitucionais que podem ser ponderados no Brasil em relação a esse tema. Diante das teses q...

  1. Os limiares planetários, a Rio+20 e o papel do Brasil

    Directory of Open Access Journals (Sweden)

    Eduardo Viola

    Full Text Available Neste artigo consideramos os problemas ambientais globais dentro do conceito de limiares planetários, em convergência com os últimos avanços das ciências naturais. Nesse contexto, nosso objetivo é explorar o papel do Brasil na governança do espaço de operação seguro para a humanidade, avaliando como o país complementa o enorme capital ambiental físico que possui com ações políticas específicas orientadas para uma economia verde de baixo carbono (EVBC, tanto no âmbito doméstico quanto no internacional. Para atingir essa meta, em primeiro lugar discutimos conceitualmente a economia verde de baixo carbono como paradigma de desenvolvimento compatível com um espaço de operação seguro para a humanidade; em segundo lugar, analisamos a Rio+20 pelo prisma da governança global dos limiares planetários e pela atuação brasileira na Cúpula; e finalmente fazemos um diagnóstico da situação do Brasil em relação ao novo paradigma de desenvolvimento. Como conclusões da análise, destacamos a crescente distância entre a aceleração dos problemas da interdependência - especialmente a definição de um espaço seguro de operação para a humanidade - e os mecanismos globais de governança existentes, derivada de um sistema internacional bloqueado e dominado por forças conservadoras. O resultado frustrante da Rio+20 é evidência clara dessa defasagem. Nessa dinâmica, o Brasil tem o potencial para ser um ator central da governança dos limiares planetários, por seu vasto capital ambiental físico. No entanto, o mínimo avanço da EVBC no país degrada essa capacidade de agência, e o torna uma potência ambiental subdesenvolvida (underachiever environmental power.

  2. PRONTUÁRIO ELETRÔNICO DO PACIENTE: REVISÃO DE LITERATURA

    Directory of Open Access Journals (Sweden)

    Luan Barbosa Hubner

    2017-03-01

    Full Text Available O prontuário eletrônico é uma ferramenta de grande auxilio para gestão em unidade básica de saúde (UBS, hospitais e clinicas. Quando falamos de prontuário eletrônico percebemos que possui vários nomes, como: Prontuário do Paciente, Prontuário Familiar, Prontuário Médico, Prontuário Hospitalar, Registro do Paciente entre outros. Com a ideia de melhorar o atendimento dos pacientes, garantir segurança para os dados e manter um histórico do paciente da sua vida toda, se seu uso for bem trabalhado com cuidado e alimentado o sistema corretamente irá ser de grande aproveitamento e ajuda para a instituição. Diante disto o objetivo do presente estudo é uma revisão de literatura, para avaliar a eficácia da implantação de um prontuário eletrônico. Nenhum estudo mostrou que o prontuário teve efeito negativo em sua implantação, apenas apresenta algumas desvantagens, sendo a implantação do prontuário eletrônico de grande valia em UBS que ainda não os possuem.

  3. The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition.

    Science.gov (United States)

    Proteggente, Anna R; Pannala, Ananth Sekher; Paganga, George; Van Buren, Leo; Wagner, Eveline; Wiseman, Sheila; Van De Put, Frans; Dacombe, Clive; Rice-Evans, Catherine A

    2002-02-01

    Recent studies are emphasising the importance and putative modes of action of specific flavonoids as bioactive components of the diet in in vivo and in vitro models. Thus, it is important to have a clear idea of the major phenolic families of which fruit and vegetables are comprised and the levels contained therein. Regularly consumed fruit and vegetables of mixed varieties available on the UK market were analysed for the composition of the major individual phenolic components. The total phenolic content (applying the Folin assay) and the vitamin C levels were also determined. The antioxidant capacities of aqueous/methanolic extracts were comparatively assessed using the TEAC (Trolox Equivalent Antioxidant Capacity), the FRAP (Ferric Reducing Ability of Plasma) and ORAC (Oxygen Radical Absorbance Capacity) assays, which comprise contributions from polyphenols, simple phenols and the ascorbate component. The results were calculated in terms of 100 g fresh weight (FW) uncooked portion sizes. Fruit and vegetables rich in anthocyanins (e.g. strawberry, raspberry and red plum) demonstrated the highest antioxidant activities, followed by those rich in flavanones (e.g. orange and grapefruit) and flavonols (e.g. onion, leek, spinach and green cabbage), while the hydroxycinnamate-rich fruit (e.g. apple, tomato, pear and peach) consistently elicited the lower antioxidant activities. The TEAC, FRAP and ORAC values for each extract were relatively similar and well-correlated with the total phenolic and vitamin C contents. The antioxidant activities (TEAC) in terms of 100 g FW uncooked portion size were in the order: strawberry> raspberry = red plum > red cabbage >grapefruit = orange > spinach > broccoli > green grape approximately/= onion > green cabbage > pea > apple > cauliflower tomato approximately/= peach=leek > banana approximately/= lettuce.

  4. Product (RED)

    DEFF Research Database (Denmark)

    Ponte, Stefano

    2011-01-01

    ) and the consumers who buy iconic brand products to help ‘distant others’. While in many other forms of causumerism, labels or certification systems ‘prove’ that a product is just, in RED, aid celebrities provide the proof. From the consumer point of view both labels and celebrities provide a similar simplification...... of complex social, economic, and environmental processes. At the same time, we argue that there are important distinctions as well—labels and certifications are ultimately about improving the conditions of production, whereas RED is about accepting existing production and trade systems and donating......(PRODUCT)RED™ (hereafter RED) is a cobranding initiative launched in 2006 by the aid celebrity Bono to raise money from product sales to support The Global Fund to Fight AIDS, Tuberculosis and Malaria. In this paper we argue that RED is shifting the boundaries of ‘causumerism’ (shopping...

  5. RED-ML

    DEFF Research Database (Denmark)

    Xiong, Heng; Liu, Dongbing; Li, Qiye

    2017-01-01

    using diverse RNA-seq datasets, we have developed a software tool, RED-ML: RNA Editing Detection based on Machine learning (pronounced as "red ML"). The input to RED-ML can be as simple as a single BAM file, while it can also take advantage of matched genomic variant information when available...... accurately detect novel RNA editing sites without relying on curated RNA editing databases. We have also made this tool freely available via GitHub . We have developed a highly accurate, speedy and general-purpose tool for RNA editing detection using RNA-seq data....... With the availability of RED-ML, it is now possible to conveniently make RNA editing a routine analysis of RNA-seq. We believe this can greatly benefit the RNA editing research community and has profound impact to accelerate our understanding of this intriguing posttranscriptional modification process....

  6. MUDANÇAS PALEO-HIDROLÓGICAS NA PLANÍCIE DO RIO PARAGUAI, QUATERNÁRIO DO PANTANAL

    Directory of Open Access Journals (Sweden)

    Hudson de Azevedo Macedo

    2014-04-01

    Full Text Available O Paraguai é o rio-tronco do trato de sistemas deposicionais do Pantanal. Com base em dados de sensores remotos e verificação de campo, foi realizado mapeamento geomorfológico da planície do rio Paraguai no trecho entre as confluências dos rios Cuiabá e Miranda, onde foram reconhecidas formas deposicionais atuais e antigas. A análise das associações de formas permitiu estabelecer proposta de evolução geomorfológica para a área, mas os eventos carecem ainda de datação precisa por métodos geocronológicos. Uma rede de drenagem abandonada multicanais está parcialmente preservada na planície, sendo composta por formas de canais com diques marginais que evidenciam período de menor descarga fluvial, provavelmente do Pleistoceno tardio ao Holoceno inferior. Um sistema constituído por paleocinturões de meandros trunca a paleorrede de drenagem multicanais, registrando aumento na umidade e na descarga fluvial. Sob essas condições o rio Paraguai construiu um sistema composto por cinturões de meandros com direção aproximada norte-sul no Holoceno inferior/médio. Agradação dos cinturões favoreceu importante evento de avulsão, com a mudança do curso do rio Paraguai para o cinturão de meandros atual no Holoceno superior. As gerações de formas identificadas e mapeadas resultaram num padrão de sobreposição de diferentes estilos fluviais, que registram significativas mudanças hidrológicas na planície desde o Pleistoceno tardio.

  7. Red Misfits in the Sloan Digital Sky Survey: properties of star-forming red galaxies

    Science.gov (United States)

    Evans, Fraser A.; Parker, Laura C.; Roberts, Ian D.

    2018-06-01

    We study Red Misfits, a population of red, star-forming galaxies in the local Universe. We classify galaxies based on inclination-corrected optical colours and specific star formation rates derived from the Sloan Digital Sky Survey Data Release 7. Although the majority of blue galaxies are star-forming and most red galaxies exhibit little to no ongoing star formation, a small but significant population of galaxies (˜11 per cent at all stellar masses) are classified as red in colour yet actively star-forming. We explore a number of properties of these galaxies and demonstrate that Red Misfits are not simply dusty or highly inclined blue cloud galaxies or quiescent red galaxies with poorly constrained star formation. The proportion of Red Misfits is nearly independent of environment, and this population exhibits both intermediate morphologies and an enhanced likelihood of hosting an active galactic nucleus. We conclude that Red Misfits are a transition population, gradually quenching on their way to the red sequence and this quenching is dominated by internal processes rather than environmentally driven processes. We discuss the connection between Red Misfits and other transition galaxy populations, namely S0s, red spirals, and green valley galaxies.

  8. Indicadores de desempenho e decisão sobre terceirização em rede pública de laboratórios Indicadores de desempeño y decisión sobre tercerización en red pública de laboratorios Performance indicators and decision making for outsourcing public health laboratory services

    Directory of Open Access Journals (Sweden)

    Maria Angelica Borges dos Santos

    2012-06-01

    indicadores de desempenho econômicos elaborados mostram a necessidade de informatização da rede, antecedendo a decisão de terceirização.OBJETIVO: Elaborar indicadores de desempeño y tercerización en red de laboratorios clínicos, basados en sistemas de informaciones y registros administrativos públicos. MÉTODOS: La red tenía 33 laboratorios con equipos automatizados pero sin informatización, 90 puestos de colecta y 983 funcionarios, en el municipio de Rio de Janeiro, Sureste de Brasil. Se obtuvo las informaciones de registros administrativos del Sistema de Informaciones de Presupuestos Públicos para la Salud y del Sistema de Informaciones de Ambulatorios y Hospitales del Sistema Único de Salud. Los indicadores, de 2006 a 2008, se refieren a la producción, productividad, utilización y costos, elaborados con datos colectados como rutina. Las variaciones de la producción, costos y precios unitarios de las pruebas en el período se analizaron por índices de Laspeyres y de Paasche, específicos para medir la actividad de los laboratorios y por el Índice de Precios al Consumidor Amplio del Instituto Brasileño de Geografía y Estadística. RESULTADOS: La producción fue de 10.359.111 pruebas en 2008 (aumentó en 10,6% con relación a 2006 y la relación pruebas/funcionario creció 8,6%. Los gastos con insumos, salarios y prestamista por convenio aumentaron, respectivamente 2,3%, 45,4% y 18,3%. Las pruebas laboratoriales por consulta e internación crecieron 10% y 20%. Los costos directos totalizaron R$ 63,2 millones en 2008, con aumento de 22,2% en valores actualizados en el período. Los costos directos disminuidos por el dice de Precios al Consumidor Amplio (9,5% para el período muestran aumento del volumen de la producción de 11,6%. El índice de volumen específico para la actividad, que considera las variaciones de la mezcla de pruebas, mostró aumento de 18,5% en el precio unitario de la prueba y de 3,1% en el volumen de la producción. CONCLUSIONES: Los

  9. CARACTERIZAÇÃO GEOMORFOLÓGICA DA BACIA DO RIO TURVO-RJ: MÉDIO VALE DO RIO PARAÍBA DO SUL (MVPRS

    Directory of Open Access Journals (Sweden)

    Rafael Albuquerque Xavier

    2014-04-01

    Full Text Available O mapeamento geomorfológico da bacia do rio Turvo confirmou as evidências apontadas em estudos anteriores, de que a bacia apresentava feições diferentes das observadas em bacias vizinhas. Foram observadas 222 depressões fechadas em divisores de drenagem, indicando forte atuação de mecanismos geoquímicos. Por outro lado, o reduzido número de voçorocas (33 e a presença de pacotes sedimentares poucos espessos (média de 7 metros, apontam a baixa efetividade dos processos mecânicos na bacia, sobretudo ao compararmos com a sub-bacia do rio Piracema, tributária do rio Bananal, com 117 voçorocas, terraços de até 23 metros de espessura e apenas 1 depressão fechada. Internamente, a bacia do rio Turvo apresentou variações, onde, de modo geral, a sub-bacia do rio das Pedras concentrou 21 das 33 voçorocas ativas, os mais espessos pacotes fluviais e apenas 16 depressões fechadas. Assim, conclui-se que a bacia do rio Turvo é fortemente influenciada pelos processos de denudação química, e a sub-bacia do rio das Pedras apresenta as maiores características da atuação do trabalho mecânico de toda a bacia.

  10. Record of Pleopis schmackeri (Poppe Branchiopoda in Rio das Ostras, Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Wanda Maria Monteiro-Ribas

    2012-10-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2013v26n1p201 The paper describes the first occurrence of Pleopis schmackeri (Poppe, 1889 (Branchiopoda, Onychopoda in Rio das Ostras, Rio de Janeiro, Brazil is described. This marine cladoceran species occurred in zooplanktonic samples obtained on July, 2003 with mean density of 10 ind.m-3. Its presence may be related to two hypotheses, due to ballast water and through the Brazilian current, which gets closer to the coast Winter.

  11. DEGRADAÇÃO AMBIENTAL DO RIO PAVUNA-MERITI

    Directory of Open Access Journals (Sweden)

    Marcos Antonio Braga de Barros

    2016-10-01

    Full Text Available O Rio Pavuna-Meriti banha em seus últimos 7,4km o município de Duque de Caxias, que segundo dados de 2014 do Instituto Brasileiro de Geografia e Estatísticas (IBGE é a 15ª maior economia do Brasil. Duque de Caxias sofre constantemente com inundações por conta do assoreamento dos rios, além da falta d’água potável que causam grande prejuízo econômico, sociais e à saúde da população. Os problemas de assoreamento existentes neste rio são comuns em outros rios do Brasil, entre suas principais causas estão o lançamento de esgotos sem tratamento, ausência de coleta de lixo, sem falar dos aspectos indiretos como desmatamento de suas margens, ocupação da calha secundária do rio.

  12. Estudo da geometria hidráulica do Rio dos Bugres, no município de Rio Negrinho - SC

    OpenAIRE

    Grison, Fernando

    2013-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Ambiental, Florianópolis, 2013. O presente trabalho aplicou a teoria da geometria hidráulica no rio dos Bugres, em várias seções e trechos desse rio. Foi feita uma comparação entre resultados da geometria hidráulica obtidos pelo método clássico proposto por Leopold com derivações analíticas propostas por Dingman. Foram definidos 11 pontos de estudo ao longo do rio dos Bugr...

  13. Fatores associados ao atraso no desenvolvimento em crianças, Rio Grande, Rio Grande do Sul, Brasil Factores asociados con retraso en el desarrollo de los niños, Rio Grande, Rio Grande do Sul, Brasil Factors associated with delay in development in children, Rio Grande, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Aline Alves Veleda

    2011-03-01

    Full Text Available Estudo analítico com o objetivo de avaliar os fatores associados ao atraso no desenvolvimento em crianças entre 8 a 12 meses de idade indicadas como de risco ao nascer no município do Rio Grande, Rio Grande do Sul, Brasil. Foram utilizados como instrumentos o Teste de Triagem de Desenvolvimento de Denver II (TTDD II, a avaliação antropométrica e questionários estruturados. Participaram 220 crianças consideradas de risco ou não ao nascer. Foi encontrada uma prevalência de 20,5% de suspeita de atraso no desenvolvimento neuropsicomotor. As crianças que apresentaram risco de um TTDD II suspeito faziam parte de famílias de mais baixa renda; eram filhos de mães que haviam realizado menos de seis consultas de pré-natal e apresentavam índice peso-idade inadequado. Os dados sugerem a necessidade de um replanejamento das políticas de saúde infantil, visto que outros critérios poderiam ser incluídos nas condições de risco para a criança ao nascer.Estudio analítico con el objetivo de evaluar los factores asociados al atraso en el desarrollo en niños de 8 a 12 meses de edad indicados como riesgo al nacer en el municipio de Rio Grande, RS, Brasil. Fueron utilizadas como herramientas la Prueba de Tamizaje del Desarrollo de Denver II, la evaluación antropométrica y cuestionarios estructurados. Participaron 220 niños considerados de riesgo o no al nacer. Fue encontrada una prevalencia del 20,5% de sospecha de atraso en el desarrollo neuropsicomotor. Los niños que presentaron riesgo de un DDST II sospechoso formaban parte de familias de más baja renta; eran hijos de madres que habían realizado menos de seis consultas de prenatal y presentaban índice peso-edad inadecuado. Los datos sugieren la necesidad de un replanteamiento de las políticas de salud infantil, así como otros criterios podrían ser inclusos en las condiciones de riesgo para el niño al nacer.This analytical study aims to evaluate the factors associated to

  14. Maconha e contexto familiar: um estudo psicossocial entre universitários do Rio de Janeiro Marijuana and family context: a psychosocial study among university students of Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Violeta Martins Ferreira

    2007-04-01

    Full Text Available O objetivo deste trabalho foi estudar o contexto familiar de usuários e não-usuários de maconha. Adotamos a teoria das representações sociais de Moscovici (1961/1976, 1988, além de algumas reflexões de Becker (1971 e Foucault (1977, 1994, 1997. Participaram da pesquisa sessenta universitários do Rio de Janeiro, de ambos os sexos, entre 17 e 30 anos. Utilizamos um questionário com perguntas abertas, no qual eles apresentaram seus familiares. O material obtido foi analisado em termos temáticos e estatísticos. Entre os usuários de maconha, prevaleceu a autoridade e a ênfase nos papéis sociais, sendo a interação familiar marcada pelo acento emocional e pela idealização. Entre os não-usuários a autoridade coexistiu com relações interpessoais de companheirismo e partilha, num contexto familiar em que predominaram não aspectos afetivos mas práticas de proteção e cuidados. Podemos afirmar que o papel da família na prevenção ao uso de drogas está associado à promoção da autonomia, diferenciação e garantia de um espaço próprio para o jovem.The objective of this paper was to study the family context among marijuana users and non-users. Moscovici's theory of social representations, as well as some considerations from Becker and Foucault, was used as theoretical basis for data analysis. The empirical research included sixty university students from Rio de Janeiro, 17-30 years old, of both sexes. Using a questionnaire with open questions, we requested participants to freely describe their family members. The answers were treated according to content analysis principles, followed by chi-square tests. The results presented significant differences between both groups. Among marijuana users, authority and emphasis of social roles predominated, family interactions being characterized by emotional emphasis and idealization. Among non-users, authority coexisted with interpersonal relations characterized by fellowship and sharing

  15. Road density not a major driver of Red-eared slider (Trachemys scripta elegans) population demographics in the Lower Rio Grande Valley of Texas

    Science.gov (United States)

    Ivana Mali; Brian E. Dickerson; Donald J. Brown; James R. Dixon; Michael R. J. Forstner

    2013-01-01

    In recent years there have been concerns over the conservation and management of freshwater turtle populations in the state of Texas. In 2008 and 2009, we completed several investigations addressing anthropogenic impacts on freshwater turtles in the Lower Rio Grande Valley (LRGV) of Texas. Here, we use a model selection approach within an information-theoretic...

  16. Bioavailability and Biokinetics of Anthocyanins From Red Grape Juice and Red Wine

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    Roland Bitsch

    2004-01-01

    Full Text Available In a comparative study, 9 healthy volunteers ingested a single oral dose of 400 mL red grape juice or red wine with dose-adjusted anthocyanin content (283.5 mg or 279.6 mg, resp. in crossover. The content of anthocyanin glucosides was detected in plasma and urinary excretion. Additionally, the plasmatic antioxidant activity was assessed after intake. Based on the plasma content, biokinetic criteria of the single anthocyanins were calculated, such as AUC, cmax, tmax, and the elimination rate t1/2. The urinary excretion of total anthocyanins differed significantly and amounted to 0.18% (red wine and 0.23% (red grape juice of the administered dose. Additionally, the plasmatic antioxidant activity increased to higher levels after juice ingestion compared to wine. The intestinal absorption of the anthocyanins of red grape juice seemed to be improved compared to red wine, suggesting a possible synergistic effect of the glucose content of the juice. The improved absorption resulted in an enhanced plasmatic bioactivity.

  17. What makes red quasars red?. Observational evidence for dust extinction from line ratio analysis

    Science.gov (United States)

    Kim, Dohyeong; Im, Myungshin

    2018-02-01

    Red quasars are very red in the optical through near-infrared (NIR) wavelengths, which is possibly due to dust extinction in their host galaxies as expected in a scenario in which red quasars are an intermediate population between merger-driven star-forming galaxies and unobscured type 1 quasars. However, alternative mechanisms also exist to explain their red colors: (i) an intrinsically red continuum; (ii) an unusual high covering factor of the hot dust component, that is, CFHD = LHD/Lbol, where the LHD is the luminosity from the hot dust component and the Lbol is the bolometric luminosity; and (iii) a moderate viewing angle. In order to investigate why red quasars are red, we studied optical and NIR spectra of 20 red quasars at z 0.3 and 0.7, where the usage of the NIR spectra allowed us to look into red quasar properties in ways that are little affected by dust extinction. The Paschen to Balmer line ratios were derived for 13 red quasars and the values were found to be 10 times higher than unobscured type 1 quasars, suggesting a heavy dust extinction with AV > 2.5 mag. Furthermore, the Paschen to Balmer line ratios of red quasars are difficult to explain with plausible physical conditions without adopting the concept of the dust extinction. The CFHD of red quasars are similar to, or marginally higher than, those of unobscured type 1 quasars. The Eddington ratios, computed for 19 out of 20 red quasars, are higher than those of unobscured type 1 quasars (by factors of 3-5), and hence the moderate viewing angle scenario is disfavored. Consequently, these results strongly suggest the dust extinction that is connected to an enhanced nuclear activity as the origin of the red color of red quasars, which is consistent with the merger-driven quasar evolution scenario. Full Table A.1 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/610/A31

  18. When red means go : non-normative effects of red under sensation seeking

    NARCIS (Netherlands)

    Mehta, R.; Demmers, J.; van Dolen, W.M.; Weinberg, C.B.

    Although previous research has identified red as the color of compliance, the current work proposes that this effect of red may not hold under high sensation-seeking propensity conditions. It is argued that the color red has the capability to induce arousal, which in turn has been shown to enhance a

  19. ICLEI submission for Rio+20. Contribution to the Zero Draft of the Rio+20 outcome document

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-10-31

    ICLEI is an association of over 1200 local government Members who are committed to sustainable development. This document is ICLEI's submission to the zero draft document being developed for RIO+20, the United Nations Conference on Sustainable Development, scheduled for June 2012 in Rio de Janeiro, Brazil. In the paper, ICLEI calls for a UN Decade of Sustainable Urbanization to raise awareness, create synergies and to share solutions and good practices.

  20. Desarrollo y validación de una metodología para la determinación de residuos de orto-fenilfenol en aceite esencial de frutas cítricas en Tucumán, R. Argentina Development and validation of a methodology for determining orto-phenylphenol residues in citrus essential oil in Tucumán, Argentina

    Directory of Open Access Journals (Sweden)

    Norma Kamiya

    (GC-FID was used for detection and quantitation. Average recoveries were the following: 89% to 104% within the range of 0.1 mg/kg to 100 mg/kg for lemon essential oil; 93% to 103% and 90% to 114%, for white and red grapefruit, respectively, within the range of 0.2 -10 mg/kg. Detection limits were 0.05 mg/kg for lemon essential oil and 0.1 mg/kg for both white and red grapefruit essential oils. Quantitation limits were 0.1 and 0.2 mg/kg for lemon and grapefruit essential oils, respectively. Also, an acceptable linearity was observed in the evaluated ranges and relative uncertainties of 24%, 14% and 23% for lemon, white and red grapefruit essential oils, respectively, were obtained.

  1. Germanidade e banhos medicinais nos primórdios dos balneários no Rio Grande do Sul Germanism and medicinal bathing in the early days of health resorts in Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Sílvio Marcus de Souza Correa

    2010-03-01

    Full Text Available Nos primórdios dos balneários no Rio Grande do Sul, encontravam-se alguns imigrantes alemães, não apenas entre os banhistas, mas também entre os empresários do incipiente ramo do curismo-turismo. Era um grupo pequeno de imigrantes de origem urbana que, em geral, já conhecia as vantagens curativas ou revigorantes dos banhos em balneários europeus. Entre eles destacavam-se os médicos, importantes emissores de um discurso científico em prol dos balneários. As práticas terapêuticas de banhos de mar chegaram ao Brasil meridional pela imigração européia da segunda metade do século XIX, embora sua difusão só tenha ocorrido na primeira metade do século seguinte, quando se desenvolveram as primeiras praias balneárias no Rio Grande do Sul.In the early days of bathing resorts some German immigrants were found not only among the bathers, but also among the entrepreneurs of the incipient branch of 'curism-tourism'. It was a small group of immigrants of urban origin who, in general, already knew the curative or reinvigorating advantages of the baths in European bathing resorts. Among them, doctors were prominent, important emissaries of a scientific discourse in favor of bathing resorts. The therapeutic practices of bathing in the sea arrived to meridional Brazil with the European immigration of the second half of the nineteenth century, although its diffusion only took place in the first half of the following century, when the first bathing beaches in Rio Grande do Sul were developed.

  2. Imaginary Documentary: reflecting upon contemporary documental photography Documentário Imaginário: reflexões sobre a fotografia documental contemporânea

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    Kátia Hallak Lombardi

    2008-01-01

    Full Text Available This article pursues the idea of an Imaginary Documentary – a possible new inflexion on the practices of contemporary documental photography. The text establishes its theoretical foundations through a forthcoming approach of the discussions about documental photography to the concept of imaginary, by Gilbert Durand, and the notion of Imaginary Museum, by André Malraux. Photographers that are part of documental photography history are the elected objects in which we shall confront the potentialities of the Imaginary Documentary. Este artigo tem como propósito buscar a estruturação da idéia de Documentário Imaginário – uma possível inflexão na prática da fotografia documental contemporânea. O texto assenta suas bases teóricas por meio da aproximação de reflexões sobre a fotografia documental ao conceito de imaginário em Gilbert Durand e à noção de Museu Imaginário de André Malraux. Fotógrafos que fazem parte da história da fotografia documental são os objetos eleitos para aferir as potencialidades do Documentário Imaginário.

  3. Male red ornamentation is associated with female red sensitivity in sticklebacks.

    Directory of Open Access Journals (Sweden)

    Ingolf P Rick

    Full Text Available Sexual selection theory proposes correlated evolutionary changes in mating preferences and secondary sexual characters based on a positive genetic correlation between preference and the preferred trait. Empirical work has provided support for a genetic covariation between female preference and male attractiveness in several taxa. Here, we study parent and offspring visual traits in threespine sticklebacks, Gasterosteus aculeatus. While focusing on the proximate basis of mating preferences, we compare the red breeding coloration of males, which strongly contributes to female choice, with their daughters' red sensitivity measured by optomotor response thresholds. We show that the red color expression of fathers correlates well with their daughters' red sensitivity. Given that a within-population genetic correlation between signal and preference was experimentally confirmed for the red coloration in sticklebacks, our results indicate a proximate mechanism in terms of perceptual sensitivity being involved in the co-evolution of female preferences and male mating signals.

  4. Don't Take This with That!

    Medline Plus

    Full Text Available ... worth the squeeze…especially when combining grapefruit with medicines. While it can be part of a balanced ... two grapefruit wedges can alter the way your medicines work. When taken with medicine, grapefruit can delay, ...

  5. Don't Take This with That!

    Medline Plus

    Full Text Available ... receives no benefit. Grapefruit can also interfere with enzymes that break down drugs in your digestive system. ... cross between tangerines and grapefruit) affect the same enzyme as grapefruit juice, so avoid these fruits as ...

  6. Don't Take This with That!

    Medline Plus

    Full Text Available ... of problems. How it does or doesn’t work Depending on the active ingredient, grapefruit can reduce ... and tangelos (a cross between tangerines and grapefruit) affect the same enzyme as grapefruit juice, so avoid ...

  7. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity.

    Science.gov (United States)

    Heggers, John P; Cottingham, John; Gusman, Jean; Reagor, Lee; McCoy, Lana; Carino, Edith; Cox, Robert; Zhao, Jian-Gang; Reagor, Lana

    2002-06-01

    Recent testimonials report grapefruit-seed extract, or GSE (Citricidal) to be effective against more than 800 bacterial and viral strains, 100 strains of fungus, and a large number of single and multicelled parasites. This study investigated GSE for antibacterial activity at varying time intervals and concentration levels and tissue toxicity at varying concentrations in an effort to determine if a concentration existed that was both microbicidal and nontoxic and in what period of time. Gram-negative and gram-positive isolates were introduced into graduated dilutions of GSE (twofold concentrations ranging from 1:1, through 1:512) for determination of bacterial activity. In vitro assays with human skin fibroblast cells were also performed at the same dilutions to determine toxicity. These tests indicated that from the 1:1 through the 1:128 concentrations, GSE remained toxic as well as bactericidal. However, test results indicated that at the 1:512 dilution, GSE remained bactericidal, but completely nontoxic. The initial data shows GSE to have antimicrobial properties against a wide range of gram-negative and gram-positive organisms at dilutions found to be safe. With the aid of scanning transmission electron microscopy (STEM), the mechanism of GSE's antibacterial activity was revealed. It was evident that GSE disrupts the bacterial membrane and liberates the cytoplasmic contents within 15 minutes after contact even at more dilute concentrations.

  8. Micetomas actinomicóticos no Rio Grande do Sul: relato de quatro casos Actinomycotic mycetomas in Rio Grande do Sul: report of 4 cases

    Directory of Open Access Journals (Sweden)

    Alberto T. Londero

    1986-03-01

    Full Text Available São relatados quatro casos de micetoma causados por Nocardia brasiliensis, ocorridos no Rio Grande do Sul. É revista a literatura rio-grandense-do-sul.Four cases of mycetoma caused by N. brasiliensis, occurring in Rio Grande do Sul (Brazil, are reported.

  9. Materialidade e memória do Rio de Janeiro nas fotografias de Augusto Malta e do projeto Rio 365

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    Débora Gauziski

    2013-12-01

    Full Text Available Neste artigo investigamos a relação da fotografia com a produção e difusão de imagens da cidade do Rio de Janeiro em dois momentos distintos: durante a modernização de Pereira Passos (início do século XX e no Rio dos megaeventos (século XXI. Em ambos os períodos históricos, a cidade sofreu profundas transformações urbanísticas e a fotografia atua como importante agente nesse processo. Para analisar o papel que a fotografia tem nesse contexto, trabalhamos com as imagens clicadas pelo fotógrafo Augusto Malta e com aquelas produzidas por usuários do Instagram no contexto do projeto Rio 365. Ao longo do artigo, nossa base teórica concentra-se em autores que trabalham ou tangenciam as questões da memória e da materialidade.

  10. A violência do Rio às portas da emergência Violence in Rio as seen from the emergency ward

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    Paulo Pinheiro

    1994-01-01

    Full Text Available Este trabalho trata de revelar o aumento dos danos físicos e lesões corporais que chegam a um hospital de emergência da Rede Municipal de Saúde do Rio de Janeiro. Como Diretor deste serviço, ao mesmo tempo que constato a mudança progressiva no perfil de atendimento do hospital, comparo-o com o crescimento da onda de criminalidade que envolveu a vida social do Rio de Janeiro.This study is intended to demonstrate the increase in bodily injuries that are currently being observed in a public hospital in Rio de Janeiro. As director of an emergency ward, I have observed a steady change in the type of hospital care provided, a phenonmenon which I ascribe to the increase in criminality engulfing the community of Rio de Janeiro.

  11. MAGISTÉRIO E CONSCIÊNCIA

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    Bernard Sesboüé

    2012-01-01

    Full Text Available Este artigo propõe uma breve reflexão sobre a relação histórica e atual entre o exercício do magistério e o necessário respeito da consciência dos crentes. Uma primeira parte retoma a evolução da consciência a partir dos tempos modernos e de suas consequências : uma nova figura da fé e da vida no seio da comunidade cristã. Uma segunda parte recapitula as diferentes formas de exercício do magistério eclesial no curso da história e as dificuldades postas por seu encontro com a modernidade. O autor apresenta então um sonho, propondo uma nova maneira de proceder: não mais a simples vigilância, mas a animação de um grande debate planetário sobre todas as dificuldades postas ao ato de crer, a fim de revivificar o sensus fidei do povo cristão. A terceira parte retoma o problema da verdade na qual magistério e consciência moderna devem encontrar um consenso autêntico. ABSTRACT: This article proposes a brief reflection on the historical and current relationship between the exercise of the Magisterium and the need to respect the conscience of believers. A first part follows the evolution of conscience from modern times and its consequences: a new figure of faith and of life within the Christian community. A second part recapitulates the different forms of exercise of the ecclesial Magisterium in the course of history and the difficulties posed by its encounter with modernity. The author proposes a dream by proposing a new way to proceed: no longer simply surveillance, but the animation of a large planetary debate about all difficulties made the act of believing, in order to give new life to the sensus fidei of Christian people. The third part takes up the problem of truth in which teaching and modern conscience must find a genuine consensus.

  12. Extract of grapefruit-seed reduces acute pancreatitis induced by ischemia/reperfusion in rats: possible implication of tissue antioxidants.

    Science.gov (United States)

    Dembinski, A; Warzecha, Z; Konturek, S J; Ceranowicz, P; Dembinski, M; Pawlik, W W; Kusnierz-Cabala, B; Naskalski, J W

    2004-12-01

    Grapefruit seed extract (GSE) has been shown to exert antibacterial, antifungal and antioxidant activity possibly due to the presence of naringenin, the flavonoid with cytoprotective action on the gastric mucosa. No study so far has been undertaken to determine whether this GSE is also capable of preventing acute pancreatic damage induced by ischemia/reperfusion (I/R), which is known to result from reduction of anti-oxidative capability of pancreatic tissue, and whether its possible preventive effect involves an antioxidative action of this biocomponent. In this study carried out on rats with acute hemorrhagic pancreatitis induced by 30 min partial pancreatic ischemia followed by 6 h of reperfusion, the GSE or vehicle (vegetable glycerin) was applied intragastrically in gradually increasing amounts (50-500 microl) 30 min before I/R. Pretreatment with GSE decreased the extent of pancreatitis with maximal protective effect of GSE at the dose 250 microl. GSE reduced the pancreatitis-evoked increase in serum lipase and poly-C specific ribonuclease activity, and attenuated the marked fall in pancreatic blood flow and pancreatic DNA synthesis. GSE administered alone increased significantly pancreatic tissue content of lipid peroxidation products, malondialdehyde and 4-hydroxyalkens, and when administered before I/R, GSE reduced the pancreatitis-induced lipid peroxidation. We conclude that GSE exerts protective activity against I/R-induced pancreatitis probably due to the activation of antioxidative mechanisms in the pancreas and the improvement of pancreatic blood flow.

  13. As Câmaras Municipais no Império Português: o exemplo do Rio de Janeiro

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    Maria Fernanda Bicalho

    1998-01-01

    Full Text Available O presente artigo visa analisar o papel representado pelas Câmaras Municipais Ultrama-rinas no interior do Império Colonial Português. Ele centra sua análise sobre a Câmara do Rio de Janeiro ao longo dos séculos XVII e XVIII, no sentido de ilustrar a composição das municipalidades, suas funções rotineiras, sua ação nos tempos de crise e de guerra, e o tipo de suas demandas dirigidas aos representantes da Coroa nos dois lados do Atlântico. Enquanto centro político-administrativo, de imposição de tributos, de comércio e defesa, o Rio de Janeiro se tornou locus privilegiado do exercício do domínio metropolitano sobre a vasta região do Atlântico-Sul. Este artigo pretende discutir as tensões, negociações e compro-missos entre a política metropo-litana e o papel de uma das mais importantes municipalidades no mundo luso-americano.The present article analises the role played by the overseas municipal councils in Portuguese Colonial Empire. It focus the Municipal Council of Rio de Janeiro during the seventeenth and eighteenth centuries, in order to illustrate the composition of the municipalities, their routine functions, their action in times of crisis and war, and the kind of it's demands to the Crown representatives on both sides of the Atlantic. As the center of political administration, tax collection, commerce, and defense, Rio de Janeiro was the privileged stage for the exercise of metropolian dominance over the vast South-Atlantic world. This article intends to discuss the tensions, negociations, and compromises between metropolitan politics and the role of one of the most important luso-american municipalities.

  14. Laboratório químico-prático do Rio de Janeiro: primeira tentativa de difusão da Química no Brasil (1812- 1819) "Laboratório químico-prático do Rio de Janeiro": the first attempt at establishing the science of Chemistry in Brazil (1812- 1819)

    OpenAIRE

    Nadja Paraense dos Santos

    2004-01-01

    Until the present date, historians of science have described inaccurately the first laboratory created in Brazil for establishing and divulging Chemistry, namely the "Laboratório Químico-Prático do Rio de Janeiro". During recent research carried out in the Arquivo do Museu Imperial (Petrópolis, RJ), I localized a document entitled "Ensaio histórico analítico das operações do Laboratório Químico-Prático do Rio de Janeiro", which allowed me to gain the relevant information to correct some of th...

  15. Noncytotoxic orange and red/green derivatives of DsRed-Express2 for whole-cell labeling

    Directory of Open Access Journals (Sweden)

    Glick Benjamin S

    2009-04-01

    Full Text Available Abstract Background Whole-cell labeling is a common application of fluorescent proteins (FPs, but many red and orange FPs exhibit cytotoxicity that limits their use as whole-cell labels. Recently, a tetrameric red FP called DsRed-Express2 was engineered for enhanced solubility and was shown to be noncytotoxic in bacterial and mammalian cells. Our goal was to create derivatives of this protein with different spectral properties. Results Building on previous studies of DsRed mutants, we created two DsRed-Express2 derivatives: E2-Orange, an orange FP, and E2-Red/Green, a dual-color FP with both red and green emission. We show that these new FPs retain the low cytotoxicity of DsRed-Express2. In addition, we show that these new FPs are useful as second or third colors for flow cytometry and fluorescence microscopy. Conclusion E2-Orange and E2-Red/Green will facilitate the production of healthy, stably fluorescent cell lines and transgenic organisms for multi-color labeling studies.

  16. ESR analysis of irradiated red peppers and commercial red peppers in Japan

    International Nuclear Information System (INIS)

    Kameya, Hiromi; Ukai, Mitsuko

    2011-01-01

    ESR analysis of γ-ray irradiated and being treated with different processing red pepper was studied. All the red peppers were commercial expect irradiated one. Processing treatment of red pepper was sun drying, mechanical processing (heating sterilization and powdering treatment). All the samples were weighted and analyzed. The ESR spectrum of the red pepper is composed of a singlet at g=2.00. This signal was originated from organic free radical. It is suggested the effect of heating treatment on the radical formation is not so large and powdering treatment will promote the radical formation of red pepper. ESR singlet signal of the irradiated red pepper showed the large signal intensity and the dose-dependence. The singlet signal intensity of irradiated powder sample showed the almost same value as compared with that of the powder sample with heating treatment. Relaxation times (T 1 and T 2 ) of the singlet signal were calculated. The relaxation behavior and relaxation times of the irradiated sample were different from that of the non-irradiated sample. The value of T 1 , the spin lattice relaxation time, of irradiated sample was increased and T 2 , the spin-spin relaxation time, of irradiated sample was decreased. We concluded that the radical formation of the red pepper is mainly depended on the powdering treatment and irradiation. (author)

  17. Red blood cell production

    Science.gov (United States)

    ... bone marrow of bones. Stem cells in the red bone marrow called hemocytoblasts give rise to all of the formed elements in blood. If a hemocytoblast commits to becoming a cell called a proerythroblast, it will develop into a new red blood cell. The formation of a red blood ...

  18. Transfusão de concentrado de hemácias na unidade de terapia intensiva Red blood cells transfusion in intensive care unit

    Directory of Open Access Journals (Sweden)

    Solange Emanuelle Volpato

    2009-12-01

    Full Text Available INTRODUÇÃO: A anemia é um problema comum na admissão dos pacientes nas unidades de terapia intensiva, sendo a prática de transfusão de concentrado de hemácias uma terapêutica freqüente. As causas de anemia em pacientes críticos que realizam transfusão de concentrado de hemácias são várias: perda aguda de sangue após trauma, hemorragia gastrointestinal, cirurgia, dentre outras. Atualmente, poucos estudos são disponibilizados sobre o uso de hemocomponentes em pacientes sob cuidados intensivos. Embora as transfusões sangüíneas sejam freqüentes em unidades de terapia intensiva, os critérios de manejo otimizados não são claramente definidos, não existindo, inclusive, guidelines específicos. OBJETIVOS: Analisar as indicações clínicas do uso do concentrado hemácia na unidade de terapia intensiva. MÉTODOS: Foram analisados os prontuários dos pacientes internados na unidade de terapia intensiva que realizaram transfusão de concentrado de hemácias no período de 1º de janeiro de 2005 a 31 de dezembro de 2005. O trabalho foi aceito pelo Comitê de Ética em Pesquisa da Universidade do Sul de Santa Catarina (UNISUL. RESULTADOS: A taxa de transfusão foi de 19,33%, tendo predomínio do gênero masculino. Prevalência de paciente com idade superior ou igual a 60 anos. A taxa de óbitos nos pacientes transfundidos com concentrado de hemácias foi de 38,22%. O critério de indicação de transfusão mais freqüente foi por baixa concentração de hemoglobina (78% com média da hemoglobina pré-transfusional de 8,11g/dl. CONCLUSÕES: Os diagnósticos pré-transfusão mais frequentes são politrauma e sepse/choque séptico. Baixa concentração de hemoglobina é o principal critério clínico com média pré-transfusional de 8,11g/dl.BACKGROUND: The anemia is a common problem upon admission of the patients in the intensive care unit being the red blood cell transfusion a frequent therapeutic. The causes of anemia in critical

  19. Archaeozoology of marine mollusks from Sambaqui da Tarioba, Rio das Ostras, Rio de Janeiro, Brazil

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    Rosa C. C. L. de Souza

    2010-06-01

    Full Text Available A reference inventory of prehistoric marine mollusks from the Rio das Ostras region was created based on an excavation carried out at the Sambaqui da Tarioba shellmound. Patterns of richness and biogeography were studied, and the representativeness of bivalve and gastropod diversities found at this archaeological site were inferred. A total of 47 taxa belonging to 28 families, most of which from unconsolidated substrates, was identified. The shellmound species composition does not differ from the present-day composition. All recorded species are characteristic of a wide transition zone between the south of the states of Espírito Santo (21°S and Rio Grande do Sul (32°S. Thus, the data show little evidence of evolution in the composition, richness,and biodiversity distribution patterns of mollusks in the Rio das Ostras region. Likewise, a reconstitution of the paleoenvironment from the functional characteristics of the shellmound species indicates that the locality's geomorphology and climate remained largely unchanged in the last 4,000 years BP.

  20. Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine.

    Science.gov (United States)

    Paine, Mary F; Widmer, Wilbur W; Pusek, Susan N; Beavers, Kimberly L; Criss, Anne B; Snyder, Jennifer; Watkins, Paul B

    2008-04-01

    We previously established furanocoumarins as mediators of the interaction between grapefruit juice (GFJ) and the model CYP3A4 substrate felodipine in healthy volunteers using a GFJ devoid of furanocoumarins. It remains unclear whether furanocoumarins mediate drug-GFJ interactions involving CYP3A4 substrates that are also P-glycoprotein substrates. The effects of furanocoumarin-free GFJ on drug disposition were further characterized by using the dual CYP3A4/P-glycoprotein substrate cyclosporine. By randomized crossover design, 18 healthy volunteers received cyclosporine (5 mg/kg) with 240 mL orange juice (control), GFJ, or furanocoumarin-free GFJ. Blood was collected over 24 h. Juice treatments were separated by > or = 1 wk. The effects of diluted extracts of each juice and of purified furanocoumarins on [3H]cyclosporine translocation in Caco-2 cells were then compared. The median (range) dose-corrected cyclosporine area under the curve and the maximum concentration with GFJ (P or = 0.50), were significantly higher than those with orange juice [15.6 (6.7-33.5) compared with 11.3 (4.8-22.0) x 10(-3) h/L and 3.0 (1.6-5.8) compared with 2.4 (1.1-3.1) mL(-1), respectively]. The median time to reach maximum concentration and terminal elimination half-life were not significantly different between the juices (2-3 and 7-8 h, respectively; P > or = 0.08). Relative to vehicle, the GFJ extract, orange juice extract, and purified furanocoumarins partially increased apical-to-basolateral and decreased basolateral-to-apical [3H]cyclosporine translocation in Caco-2 cells, whereas the furanocoumarin-free GFJ extract had negligible effects. Reanalysis of the clinical juices identified polymethoxyflavones as candidate P-glycoprotein inhibitors in orange juice but not in GFJ. Furanocoumarins mediate, at least partially, the cyclosporine-GFJ interaction in vivo. A plausible mechanism involves the combined inhibition of enteric CYP3A4 and P-glycoprotein.

  1. Thermoluminescence dating of Rio Claro and Piracununga formations

    International Nuclear Information System (INIS)

    Ferreira, Sandra Regina; Chang, Maria Rita Caetano

    2008-01-01

    The Rio Claro and Piracununga formations cover extensive areas of the Paulista Peripheral Depression, dominantly in the region of Rio Claro and Piracununga cities. These units lie over the Corumbatai and Piramboia formations, exhibiting discordant contacts. The Rio Claro and Piracununga formations are composed of fine to medium sand facies, showing local cross-stratifications and parallel beddings with thin interbeddings of mud and gravel. These sands were dated by the Thermoluminescence Method, which indicated they were from the Pleistocene age. The oldest age (745,000 years BP) was found in deposits of the Rio Claro Formation; the other ages varied from 400,000 years BP to 145,000 years BP, for both formations. The youngest age (15,000 years BP - close to Pleistocene/ Holocene limit) was found in colluvial deposits, which rest on the Piracununga Formation. (author)

  2. Desgaste ondulatório em caminhos de ferro

    OpenAIRE

    Martins, Paulo Manuel Caldeira

    2010-01-01

    Trata-se de uma análise técnica completa a um desgaste específico que aparece frequentemente nos sistemas ferroviários, sejam eles comboios (passageiros, carga e alta velocidade), Metropolitanos (ligeiros e pesados) ou mesmo sistemas de carros eléctricos. Anualmente são gastos pelos sistemas ferroviários, consideráveis somas na correcção dos defeitos provocados pelo aparecimento do desgaste ondulatório nos carris de rolamento. Ainda hoje a relativa pouca troca de conhecimentos entre os ...

  3. Efficacy of a grapefruit extract on head lice: a clinical trial.

    Science.gov (United States)

    Abdel-Ghaffar, Fathy; Semmler, Margit; Al-Rasheid, Khaled; Klimpel, Sven; Mehlhorn, Heinz

    2010-01-01

    Twenty children aging 2-9 years old--four boys with short hair and 16 girls with long hair--were included in a clinical test on the efficacy of a product against head lice (Pediculus humanus capitis). Their hair were exposed to Licatack, which is a recently developed new anti-louse medicinal product containing extracts of grapefruits besides high quality shampoo components. Prior to this field trial, the product Licatack was tested dermatologically to be skin safe receiving the grade "very good". The children's mothers combed the kids prior to the start of the test in order to confirm that they were all lice-infested. The obtained lice were used for in vitro tests. All children were heavily infested. After combing and preservation of the living lice, the hair was wet with tap water. Then, 50 ml of the Licatack shampoo was placed onto the top of each child's head. Then, the mothers distributed the rather fluid product all over the hair thoroughly from their base at the skin until the free end. During this process, a type of massage, the product became foamy and it was easily recognized where the product covered the hair, thus, avoiding untreated spots. The hair of half of the treated children were washed with tap water after 10 min of exposition; while in the other half of the children, the exposition period was prolonged to 20 min before washing. When combing the kids with a metal louse comb after the washing, the lice were found immobile and they did not recover during the following observation period of 4 h. Only two lice from the group with an exposition time of only 10 min showed some slight leg movements after they had been combed off, but they died within the next 2 h. Thus, this new anti-louse medicinal product has a very quick and efficient activity besides its advantages of being non-inflammable, skin safe, and nice smelling. None of the kids claimed any burning at the skin or other side effects, although the skin showed, prior to treatment, lots of scars

  4. Blood parasites infections in domiciled dogs in an animal health service in Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Paulo Daniel Sant’Anna Leal

    2015-12-01

    Full Text Available ABSTRACT. Leal P.D.S., Moraes M.I.M.R., Barbosa L.L. deO. & Lopes C.W.G. [Blood parasites infections in domiciled dogs in an animal health service in Rio de Janeiro, Brazil.] Infecção por hematozoários nos cães domésticos atendidos em serviço de saúde animal, Rio de Janeiro, Brasil. Revista Brasileira de Medicina Veterinária, 37(Supl.1:55-62, 2015. Curso de Pós-Graduação de Ciências Veterinárias, Anexo 1, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, BR 465 Km 7, Campus Seropédica, BR 465 Km 7, Seropédica, RJ 23890-970, Brasil. E-mail: pauloleal@ctiveterinario.com.br The vector-borne diseases in dogs are caused by pathogens with different biological behaviors that result in different clinical and laboratory findings presentations. The diagnosis of these diseases is a challenge for veterinarians and those caused by obligate intracellular blood parasites of blood cells constitute vogeli of Babesia canis, Anaplasma platys, Erhlichia canis and Mycoplasma canis. This paper looks at the frequency of these parasites in 204 laboratory results dogs treated at the Intensive Care Unit and Emergency Veterinary through CBC and research of blood parasites in blood estiraço and concentrate platelets and leukocytes. There was one or more species of haemoparasites in 132 dogs (64.7% through blood samples. They were observed: 7 (5.3% dogs for B. c. vogeli, 64 (48.5% for A. platys, 16 (12.2% for M. canis, A. platys and E. canis in one (0.7%, A. platys and M. canis in 36 dogs (27.3%, M. canis and B. c. vogeli five (3.8%, M. canis and E. canis one (0.7%, A. platys, B. c. vogeli and M. canis in two (1.50%, confirming thus the high frequency of blood parasites in pet dogs in an urban environment, treated in the routine, the importance of viewing parasitic inclusions in leukocytes, platelets and red blood cells, It thus demonstrating the need for greater attention to the diagnosis of multiple infections by different parasitic

  5. A Review of Prevention, Diagnosis and Treatment of Relative Energy Deficiency in Sport (RED-S) in Artistic (Synchronized) Swimming.

    Science.gov (United States)

    Robertson, Sherry; Mountjoy, Margo

    2018-05-03

    The syndrome Relative Energy Deficiency in Sport (RED-S) is a clinical entity characterized by low energy availability (LEA), which can negatively affect the health and performance of both male and female athletes. The underlying mechanism of RED-S is an inadequacy of dietary energy to support optimal health and performance. This syndrome refers to impaired physiological function including metabolic rate, menstrual function, bone health, immunity, protein synthesis, and cardiovascular health, with psychological consequences which can either precede (through restrictive dietary habits) or result from RED-S. The term RED-S extends beyond the condition termed the "Female Athlete Triad". Formerly known as synchronized swimming, artistic swimming is an Olympic sport requiring a high level of fitness as well as technical skill and artistry. The risk of RED-S is high in artistic swimming as it is an aesthetic, judged sport with an emphasis on a lean physique. RED-S is of significant concern in the sport of artistic swimming because of the potential negative effects on physical and mental health as well as consequences on athletic performance. This paper reviews health and performance consequences associated with LEA resulting in RED-S in artistic swimming. Medical and nutritional considerations specific to artistic swimming are reviewed and methods to help detect and manage RED-S are discussed. Prevention and management of RED-S in this athlete population should be a priority for coaches and the sport medicine professionals working with artistic swimming athletes should utilize the RED-S CAT, a Clinical Assessment Tool for screening and managing RED-S.

  6. Banco de sementes de arroz vermelho em sistemas de semeadura de arroz irrigado Red rice seed bank under seeding systems of flooded rice

    Directory of Open Access Journals (Sweden)

    Luis Antonio de Avila

    2000-10-01

    Full Text Available O experimento foi conduzido com o objetivo de estimar a variação do banco de sementes viáveis de arroz vermelho (Oryza sativa L., em três sistemas de semeadura de arroz (O. sativa L. irrigado (semeadura convencional, direta e com sementes pré-germinadas, após três anos de cultivo na mesma área, em São Borja, RS, em solo classificado como Planossolo, com infestação média de 150 plantas de arroz vermelho por m² antes da instalação do experimento. A coleta do solo para estimativa do banco de sementes de arroz vermelho foi realizada com um trado cilíndrico de metal de 10cm de diâmetro. Foram realizadas amostragens de solo, com 12 amostras por parcela em duas profundidades (0-1cm e 1-10cm, para retirar os grãos de arroz vermelho, submetê-los ao teste de tetrazólio e determinar sua viabilidade. O experimento foi um bifatorial em blocos ao acaso, com três repetições, com os sistemas de semeadura de arroz como fator principal e as profundidades de coleta como fator secundário. Os dados demonstraram que o número de sementes viáveis de arroz vermelho no solo foi maior na área onde o arroz foi cultivado no sistema de semeadura convencional (1994 sementes/m², com valores intermediários para o sistema de semeadura direta (597 sementes/m² e menores valores para o sistema de semeadura com sementes pré-germinadas (93 sementes/m². Assim, demonstra-se que a semeadura de arroz no sistema de sementes pré-germinadas favorece o controle do arroz vermelho, mantendo a quantidade de sementes em densidades menores do que nos sistemas de semeadura direta e convencional.An experiment was conducted aiming to estimate the variability of viable seeds of red rice (Oryza sativa L. in soil under three rice (O. sativa L. seeding systems: conventional, no-tillage and water seeded. It was located in São Borja, Rio Grande do Sul state, Brazil, in an albaqualf soil with an average of 150 red rice plants per square meter before establishing the

  7. 75 FR 23664 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2010-05-04

    ... grapefruit from Mexico that transit the United States en route to foreign countries. Need and Use of the...: Untreated Oranges, Tangerines, and Grapefruit from Mexico Transiting the United States to Foreign Countries... from Mexico that transit the United States. Untreated oranges, tangerines, and grapefruit from Mexico...

  8. Formation and spreading of Red Sea Outflow Water in the Red Sea

    Science.gov (United States)

    Zhai, Ping; Bower, Amy S.; Smethie, William M.; Pratt, Larry J.

    2015-09-01

    Hydrographic data, chlorofluorocarbon-12 (CFC-12) and sulfur hexafluoride (SF6) measurements collected in March 2010 and September-October 2011 in the Red Sea, as well as an idealized numerical experiment are used to study the formation and spreading of Red Sea Outflow Water (RSOW) in the Red Sea. Analysis of inert tracers, potential vorticity distributions, and model results confirm that RSOW is formed through mixed-layer deepening caused by sea surface buoyancy loss in winter in the northern Red Sea and reveal more details on RSOW spreading rates, pathways, and vertical structure. The southward spreading of RSOW after its formation is identified as a layer with minimum potential vorticity and maximum CFC-12 and SF6. Ventilation ages of seawater within the RSOW layer, calculated from the partial pressure of SF6 (pSF6), range from 2 years in the northern Red Sea to 15 years at 17°N. The distribution of the tracer ages is in agreement with the model circulation field which shows a rapid transport of RSOW from its formation region to the southern Red Sea where there are longer circulation pathways and hence longer residence time due to basin wide eddies. The mean residence time of RSOW within the Red Sea estimated from the pSF6 age is 4.7 years. This time scale is very close to the mean transit time (4.8 years) for particles from the RSOW formation region to reach the exit at the Strait of Bab el Mandeb in the numerical experiment.

  9. A paisagem de rios urbanos

    OpenAIRE

    Porath, Soraia Loechelt

    2004-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Arquitetura e Urbanismo Os rios têm sido uma presença constante na formação e crescimento das cidades. Desde os primórdios das civilizações, por uma questão de sobrevivência e utilidade, servem como fonte de recursos e meio de circulação. Porém, os rios urbanos são mal compreendidos. São entendidos como um limite ao crescimento das cidades, um obstáculo a ser transposto, e dest...

  10. Physical and Chemical Properties of Sintering Red Mud and Bayer Red Mud and the Implications for Beneficial Utilization

    Science.gov (United States)

    Wang, Ping; Liu, Dong-Yan

    2012-01-01

    Performances of two common types of red mud, Bayer red mud and Sintering red mud, were investigated in this research. Their compositions, mechanical properties and microstructure characterization were measured through XRD, TG and SEM analysis. Their shear strength, particle size, density and hydraulic characteristics also had been performed. Huge differences between the basic mineral types of these two kinds of red mud also can be found. The comparison of compositions shows that CaCO3 content in Sintering red mud is higher, Bayer red mud has more hazardous elements such as As, Pb and Hg and both have a high concentration of radioactivity. The micro particle of Bayer red mud is finer and more disperse, but the Sintering red mud has higher shear strength. Combining the TG and hydraulic characteristics analysis, it can be shown that Bayer red mud has higher value of water content and Sintering red mud has higher hydraulic conductivity. The paper then illustrates that Sintering red mud can become the main filling material of supporting structure of red mud stocking yard. Bayer red mud has a high reuse value and also can be used as a mixing material of masonry mortar.

  11. Don't Take This with That!

    Medline Plus

    Full Text Available ... over-the-counter drugs known to the U.S. Food and Drug Administration that can have negative interactions with grapefruit. As little as one cup of juice or two grapefruit wedges can alter the way your medicines work. When taken with medicine, grapefruit can delay, decrease, ...

  12. Is the clinical relevance of drug-food and drug-herb interactions limited to grapefruit juice and Saint-John's Wort?

    Science.gov (United States)

    Mouly, Stéphane; Lloret-Linares, Célia; Sellier, Pierre-Olivier; Sene, Damien; Bergmann, J-F

    2017-04-01

    An interaction of drug with food, herbs, and dietary supplements is usually the consequence of a physical, chemical or physiologic relationship between a drug and a product consumed as food, nutritional supplement or over-the-counter medicinal plant. The current educational review aims at reminding to the prescribing physicians that the most clinically relevant drug-food interactions may not be strictly limited to those with grapefruit juice and with the Saint John's Wort herbal extract and may be responsible for changes in drug plasma concentrations, which in turn decrease efficacy or led to sometimes life-threatening toxicity. Common situations handled in clinical practice such as aging, concomitant medications, transplant recipients, patients with cancer, malnutrition, HIV infection and those receiving enteral or parenteral feeding may be at increased risk of drug-food or drug-herb interactions. Medications with narrow therapeutic index or potential life-threatening toxicity, e.g., the non-steroidal anti-inflammatory drugs, opioid analgesics, cardiovascular medications, warfarin, anticancer drugs and immunosuppressants may be at risk of significant drug-food interactions to occur. Despite the fact that considerable effort has been achieved to increase patient' and doctor's information and ability to anticipate their occurrence and consequences in clinical practice, a thorough and detailed health history and dietary recall are essential for identifying potential problems in order to optimize patient prescriptions and drug dosing on an individual basis as well as to increase the treatment risk/benefit ratio. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. “Gringo panic”: estrangeiros predadores, eventos esportivos globais e prostituição no Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Gregory Mitchell

    2016-12-01

    Full Text Available In the run-up to the 2014 World Cup, sectors of the media, NGOs, and the state contributed to a growing panic about prostitution. Violent police raids on legal commercial sex venues increased and police invited the media to broadcast them closing the most visible sexual tourist venue on the opening day of the Cup. In truth, prostitution did not increase in Rio de Janeiro and there were no proven instances of sex trafficking linked to the event in that city. The “clean-up” of red light districts was a land grab aimed at social cleansing and “urban renewal” in Copacabana (Rio de Janeiro. This paper examines how state and non-state actors constructed images of gringos – often as predatory interlopers – to create a moral panic in order to further their own agendas. Drawing on ethnographic fieldwork conducted among sex workers and clients before, during and after the Cup, this research examines the fantasies projected onto gringos by various constituents – sex workers, media sectors, evangelical Christians, feminists, and others. It argues that gringo clients during the Cup are best understood as atypical sex tourists with diminished agency who experienced key differences in social capital and cultural competency. The reliance on misinformed ideas of gringo masculinity has unintended social consequences, including the further marginalization of vulnerable women working in Rio’s sexual economy.

  14. Desempenho de Novilhos Red Angus Superprecoces, Confinados e Abatidos com Diferentes Pesos Feedlot Performance of Young Red Angus Steers Slaughtered at Different Body Weights

    Directory of Open Access Journals (Sweden)

    Eduardo Castro da Costa

    2002-02-01

    Full Text Available Foi avaliado o desempenho em confinamento de machos Red Angus confinados a partir dos oito meses de idade, quando apresentavam peso vivo médio de 189 kg, até atingirem os seguintes pesos pré-determinados (PA: 340, 370, 400 e 430 kg. O número de dias necessários para atingir os respectivos pesos foram de 114, 144, 168 e 209 dias, com 12, 13, 14 e 15 meses de idade. Os animais foram alimentados com uma dieta contendo 13,13% de proteína bruta e relação volumoso (silagem de milho:concentrado de 56:44. O ganho de peso médio diário foi de 1,32; 1,27; 1,23; e 1,15 kg respectivamente. O consumo médio diário de matéria seca (CMS, expresso em kg/dia/animal e por peso metabólico, não apresentou relação significativa com o peso de abate. Quando o CMS foi expresso por 100 kg de peso vivo, houve queda linear (CMS/100 kg PV= 3,599 - 0,003152PA em relação ao aumento do peso de abate. O estado corporal melhorou linearmente com o aumento do peso de abate (ECF= 0,159 + 0,0103PA, enquanto a conversão alimentar piorou (CAMS= 1,585 + 0,01019PA, porém a mesma pode ser considerada muito boa, sendo, respectivamente, de 5,09; 5,35; 5,55; e 6,04 kg de MS/kg de ganho de peso. Foi estimado, por intermédio da equação de regressão, que, para atender o peso de carcaça e a gordura de cobertura mínimos exigidos, o peso de abate deveria ser de 337 e 327 kg, respectivamente.The feedlot performance of Red Angus steers, with initial age of eight months and 189 kg of initial live weight, fed to reach the slaughter weight (SW of 340, 370, 400 or 430 kg, was evaluated. The number of days to reach the respective weight was 114, 144, 168 and 209 days, with 12, 13, 14 and 15 months of age. The animals were fed with a 13.13% crude protein diet, and roughage:concentrate ratio of 56:44. The average daily gain was 1.32, 1.27, 1.23 and 1.15 kg, respectively. Dry matter intake (DMI expressed in kg/day/animal and metabolic weight, did not show significant relation with

  15. Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein.

    Science.gov (United States)

    Dahan, Arik; Amidon, Gordon L

    2009-04-01

    To investigate the potential interaction between grapefruit juice (GFJ) and the oral microtubule polymerization inhibitor colchicine, a P-gp and CYP3A4 substrate. Colchicine intestinal epithelial transport was investigated across Caco-2 cell monolayers in both AP-BL and BL-AP directions, in the absence/presence of known P-gp inhibitors (verapamil and quinidine). The concentration-dependent effects of GFJ and its major constituents (6'-7'-dihydroxybergamottin, naringin and naringenin) on colchicine Caco-2 mucosal secretion were examined. The effect of GFJ on colchicine intestinal-permeability was then investigated in-situ in the rat perfusion model, in both jejunum and ileum. Colchicine exhibited 20-fold higher BL-AP than AP-BL Caco-2 permeability, indicative of net mucosal secretion, which was reduced by verapamil/quinidine. Colchicine AP-BL permeability was increased and BL-AP was decreased by GFJ in a concentration-dependent manner (IC(50) values of 0.75% and 0.46% respectively), suggesting inhibition of efflux transport, rather than metabolizing enzyme. Similar effects obtained following pre-experiment incubation with GFJ, even though the juice was not present throughout the transepithelial study. 6'-7'-Dihydroxybergamottin, naringin and naringenin displayed concentration-dependent inhibition on colchicine BL-AP secretion (IC(50) values of 90, 592 and 11.6 microM respectively). Ten percent GFJ doubled colchicine rat in-situ ileal permeability, and increased 1.5-fold jejunal permeability. The data suggest that GFJ may augment colchicine oral bioavailability. Due to colchicine narrow therapeutic-index and severely toxic side-effects, awareness of this interaction is prudent.

  16. Red is Romantic, but Only for Feminine Females: Sexual Dimorphism Moderates Red Effect on Sexual Attraction

    Directory of Open Access Journals (Sweden)

    Fangfang Wen

    2014-10-01

    Full Text Available Previous researchers have documented that the color red enhances one's sexual attraction to the opposite sex. The current study further examined the moderating role of sexual dimorphism in red effects. The results indicated that red enhanced men's sexual attraction to women with more feminine facial characteristics but had no effect on ratings of perceived general attractiveness. Red clothing also had a marginally significant effect on men's sexual attractiveness. In addition, regardless of sexual dimorphism cues, male participants rated women with red as warmer and more competent. The underlying mechanisms of the red effect, the limitations of the current study, and suggestions for future directions are discussed.

  17. Seeing Red: Inside the Science and Politics of the IUCN Red List

    Directory of Open Access Journals (Sweden)

    Lisa M Campbell

    2012-01-01

    Full Text Available The Red List of Threatened Species™ (hereafter Red List is the International Union for the Conservation of Nature′s most recognisable product. The Red List categorises the conservation status of species on a global scale using ′the most objective, scientifically-based information′. Completing Red List assessments is the job of the Species Survival Commission (SSC, and assessments are most often conducted by species specialist groups within the SSC. In the SSC′s Marine Turtle Specialist Group (MTSG, assessments have been contested. Debate is often couched in scientific terms, focused on data availability and the relevance of Red List criteria for marine turtles. However, given the potential conservation impacts of such listings, much more is at stake. In this paper, I analyse an exchange among MTSG members that resulted when the draft Red List assessment for the hawksbill sea turtle was circulated to the group in June 2007. The suggested listing of hawksbill turtles as ′critically endangered′ sparked an email exchange that highlighted not only the scientific, but also the political, economic, and value-based dimensions of the debate. I draw on ideas of co-production and boundary work to analyse both the debate and the MTSG′s response to an associated crisis of legitimacy, and to provide insights into the science-policy interface in conservation.

  18. Pyxiloricaria menezesi, a new genus and species of mailed catfish from Rio Miranda and Rio Cuiabá, Brazil (Pisces, Siluriformes, Loricariidae)

    NARCIS (Netherlands)

    Isbrücker, I.J.H.; Nijssen, H.

    1984-01-01

    Pyxiloricaria menezesi n. gen., n. sp., is described and illustrated from Rio Miranda (Est. Mato Grosso do Sul) and from Rio Cuiabá (Est. Mato Grosso), Brazil. It is assigned to the subtribe Planiloricariina of the tribe Loricariini, subfamily Loricariinae. A comparison is made with sympatric

  19. Tratamento conjugado de lixiviado de aterro sanitário e esgoto sanitário em lagoas de estabilização rasas

    OpenAIRE

    Campos, Andrezza Raphaella Costa

    2012-01-01

    A busca para desenvolver alternativas viáveis e eficientes para o tratamento do lixiviado de aterro sanitário, fez com que surgisse a iniciativa de pesquisar sobre o tratamento conjugado entre lixiviado de aterro sanitário e esgoto sanitário, visando tratar o lixiviado diluindo este no esgoto, reduzindo as elevadas concentrações de matéria orgânica e nitrogênio amoniacal, deixando em proporções adequadas ao tratamento convencional. Neste estudo, foi analisada a eficiência do processo de trata...

  20. Construção de uma escala de ansiedade para pacientes de ambulatório: um es tu do exploratório

    OpenAIRE

    Oliveira, José Carlos Silva; Sisto, Fermino Fernandes

    2009-01-01

    O presente trabalho teve como objetivo estudar a possibilidade de construção de uma escala para avaliar a ansiedade de pessoas em ambulatório. Participaram 636 pacientes, atendidos no ambulatório pelos serviços de saúde de um hospital universitário, nas áreas de Cardiologia, Clínica Médica, Dermatologia, Endocrinologia, Gastroenterologia, Ginecologia, Neurologia, Oftalmologia, Ortopedia e Urologia, com idades entre 25 e 50 anos. O instrumento foi composto por 57 frases e, em uma primeira anál...

  1. Distribution of 'Candidatus Liberibacter asiaticus' Above and Below Ground in Texas Citrus.

    Science.gov (United States)

    Louzada, Eliezer S; Vazquez, Omar Ed; Braswell, W Evan; Yanev, George; Devanaboina, Madhavi; Kunta, Madhurababu

    2016-07-01

    Detection of 'Candidatus Liberibacter asiaticus' represents one of the most difficult, yet critical, steps of controlling Huanglongbing disease. Efficient detection relies on understanding the underlying distribution of bacteria within trees. To that end, we studied the distribution of 'Ca. L. asiaticus' in leaves of 'Rio Red' grapefruit trees and in roots of 'Valencia' sweet orange trees grafted onto sour orange rootstock. We performed two sets of leaf collection on grapefruit trees; the first a selective sampling targeting symptomatic leaves and their neighbors and the second a systematic collection disregarding symptomology. From uprooted orange trees, we exhaustively sampled fibrous roots. In this study, the presence of 'Ca. L. asiaticus' was detected in leaves using real-time polymerase chain reaction (PCR) targeting the 16S ribosomal gene and in roots using the rpIJ/rpIL ribosomal protein genes and was confirmed with conventional PCR and sequencing of the rpIJ/rpIL gene in both tissues. Among randomly collected leaves, 'Ca. L. asiaticus' was distributed in a patchy fashion. Detection of 'Ca. L. asiaticus' varied with leaf symptomology with symptomatic leaves showing the highest frequency (74%) followed by their neighboring asymptomatic leaves (30%), while randomly distributed asymptomatic leaves had the lowest frequency (20%). Among symptomatic leaves, we found statistically significant differences in mean number of bacterial cells with respect to both increasing distance of the leaf from the trunk and cardinal direction. The titer of 'Ca. L. asiaticus' cells was significantly greater on the north side of trees than on the south and west sides. Moreover, these directions showed different spatial distributions of 'Ca. L. asiaticus' with higher titers near the trunk on the south and west sides as opposed to further from the trunk on the north side. Similarly, we found spatial variation in 'Ca. L. asiaticus' distribution among root samples. 'Ca. L. asiaticus

  2. Sistema internacional de hegemonia conservadora: o fracasso da Rio + 20 na governança dos limites planetários

    Directory of Open Access Journals (Sweden)

    Eduardo Viola

    2012-12-01

    Full Text Available Em um artigo seminal, Rockström et al. (2009 inauguraram uma nova forma de abordar os problemas ambientais. A abordagem das fronteiras planetárias aparece como um instrumento analítico fundamental para avaliar a governança global do ambiente e, em um sentido mais profundo, para refletir sobre o rumo civilizatório da humanidade. O nosso objetivo nesse artigo, é fazer uma avaliação da Rio+20 utilizando como critério a governança global das fronteiras planetárias. No caminho, fazemos especial referência ao papel do Brasil na Cúpula. Nossa conclusão principal é que a Rio+20 foi um fracasso desde o ponto de vista da definição de um espaço de operação segura para a humanidade e que ele é expressão de um sistema internacional bloqueado e dominado por forças conservadoras. Nesse cenário, o Brasil aparece como uma potência ambiental subdesenvolvida (underachiever environmental power: a combinação de um enorme capital ambiental físico com um deficiente capital ambiental social.En un trabajo seminal, Rockström et al (2009 inauguraron una nueva forma de abordar la problemática ambiental, basada en la noción de fronteras planetarias. Esa perspectiva aparece como un instrumento analítico fundamental para evaluar la gobernanza del medio ambiente y en un sentido mas profundo, el propio rumbo de la civilización. El objetivo de este artículo es hacer un balance de la Rio+20 usando como criterio la gobernanza global de las fronteras planetarias, así como analizar el papel de Brasil en la Cumbre. La conclusión principal es que la Rio+20 fue un fracaso desde el punto de vista de la definición de un espacio de operación segura para la humanidad, fracaso que es expresión de un sistema internacional bloqueado y dominado por fuerzas conservadoras. En ese escenario, Brasil aparece como una potencia ambiental subdesarrollada (underachiever environmental power por combinar un vasto capital ambiental físico con un deficiente capital

  3. Comparative Study of Betacyanin Profile and Antimicrobial Activity of Red Pitahaya (Hylocereus polyrhizus) and Red Spinach (Amaranthus dubius).

    Science.gov (United States)

    Yong, Yi Yi; Dykes, Gary; Lee, Sui Mae; Choo, Wee Sim

    2017-03-01

    Betacyanins are reddish to violet pigments that can be found in red pitahaya (Hylocereus polyrhizus) and red spinach (Amaranthus dubius). This study investigated the impact of sub-fractionation (solvent partitioning) on betacyanin content in both plants. Characterization of betacyanins and evaluation of their antimicrobial activities were also carried out. Betanin was found in both plants. In addition, isobetanin, phyllocactin and hylocerenin were found in red pitahaya whereas amaranthine and decarboxy-amaranthine were found in red spinach. Sub-fractionated red pitahaya and red spinach had 23.5 and 121.5 % more betacyanin content, respectively, than those without sub-fractionation. Sub-fractionation increased the betanin and decarboxy-amaranthine content in red pitahaya and red spinach, respectively. The betacyanin fraction from red spinach (minimum inhibitory concentration [MIC] values: 0.78-3.13 mg/mL) demonstrated a better antimicrobial activity profile than that of red pitahaya (MIC values: 3.13-6.25 mg/mL) against nine Gram-positive bacterial strains. Similarly, the red spinach fraction (MIC values: 1.56-3.13 mg/mL) was more active than the red pitahaya fraction (MIC values: 3.13-6.25 mg/mL) against five Gram-negative bacterial strains. This could be because of a higher amount of betacyanin, particularly amaranthine in the red spinach.

  4. Por uma memória do cinema documentário no Rio Grande do Sul: desafios para uma nova historiografia do cinema brasileiro

    Directory of Open Access Journals (Sweden)

    Cássio dos Santos Tomaim

    2010-12-01

    Full Text Available A partir de pesquisa bibliográfica e consulta a catálogos e dicionários de filmes brasileiros, buscamos uma compreensão histórica da produção de documentários no Rio Grande do Sul, a fim de problematizar a memória deste cinema. Primeiro foi preciso existir o cinema de não-ficção no Estado, em especial o de curta-metragem, para somente mais tarde ser possível o longa-metragem de ficção gaúcho. Indicativo de que a história do cinema no Rio Grande do Sul não é uma coleção de episódios isolados, como nos fez acreditar a historiografia clássica do cinema brasileiro.

  5. GO RIO: Achieving Universal Access to Mass Transit

    Science.gov (United States)

    Martinez, Ted, Jr.; Castaneda-Calleros, Russell

    2009-01-01

    GO RIO is a universal access, mass-transit program that has been offered to all students who are registered full-time at Rio Hondo College. Through an agreement with five local transit agencies, full-time students can obtain a pass that provides full access seven days a week throughout the entire semester.

  6. Research of the Rio Grande Ecosystem Management Program

    Science.gov (United States)

    Deborah M. Finch

    2000-01-01

    This paper describes the mission, objectives, and preliminary results of the Middle Rio Grande Ecosystem Management Research Program managed at the Rocky Mountain Research Station's Albuquerque laboratory. This program was initiated in 1994 to address growing pressures to effectively manage the limited resources of the middle Rio Grande Basin. The program is...

  7. Skin quality in red potatoes

    Science.gov (United States)

    Attractive appearance is a highly desirable characteristic of fresh market red-skinned potatoes. The ideal red potato has a rich, uniform, deep red color. Color fading, netting, browning, and discoloration caused by skinning and disease decrease marketability and may reduce profits to growers and pa...

  8. Um Visitante do Rio de Janeiro Colonial

    Directory of Open Access Journals (Sweden)

    Jean M. Carvalho França

    1997-01-01

    Full Text Available O texto que se segue é a tradução de um manuscrito francês, intitulado Relâche du Vaisseau L'Arc-en-ciel à Rio de Janeiro, 1748, que se encontra na Biblioteca da Ajuda, em Lisboa. Trata-se de um relato anônimo, que dá conta da passagem do navio francês L'Arc-en-ciel pelo porto carioca. Tal relato, um curioso documento para a história dos nossos costumes, contém uma descrição da baía da Guanabara e da cidade do Rio de Janeiro, uma pequena análise do caráter da gente portuguesa do Brasil, um perfil do Governador Dom Fernando Freire e algumas considerações gerais sobre a situação do porto local e sobre os víveres disponíveis na região.The following text is a translation of a French manuscript named Relachê du Vaisseau L'Arc-en-ciel à Rio de Janeiro, 1748, which is in Biblioteca da Ajuda (Ajuda Library in Lisbon. It is an anonymous report and relates the stay of the French ship L'Arc-en-ciel in Rio de Janeiro harbour. Such report, a curious document for the history of our customs, has a description of Guanabara bay and Rio de Janeiro city, a brief analysis of the character of the Portuguese people in Brazil, a prolife of Governor Dom Fernando Freire and some considerations of the situation of local harbour and on the provisions available in that region.

  9. Laboratórios na Área de Ensino de Línguas

    Directory of Open Access Journals (Sweden)

    José Carlos Paes de Almeida Filho

    2017-03-01

    Full Text Available O imaginário do laboratório como local de experimentação e invenções acrescentou um sentido novo a esse lugar de nascimento do conhecimento quando o Ensino de Línguas deu a essa palavra o sentido de local de prática de produção automatizadora de uma nova língua nos anos 60 e 70 do século anterior. A realidade metodológica estrutural audiolingual com sua ênfase oral na forma sistêmica rotinizadora para atender princípios psicológicos da superaprendizagem deu as condições necessárias para a invenção do laboratório de línguas que consolidou o nome laboratório associado ao ensino e aprendizagem de idiomas. Passados quase cinquenta anos da introdução do laboratório de línguas, qual o cenário de sentidos de um laboratório para os dias de hoje?  Para explorar o arco de sentidos que foram organicamente se condensando na área de Ensino de Línguas e para avaliar os sentidos de lugar e práticas condizentes de um laboratório, sete significados foram reconhecidos na prática contemporânea para que alunos de graduação em Letras (Linguagem, futuros professores e pesquisadores, e mestres já atuando na prática pudessem avaliar as possibilidades de se criar ou manter um laboratório justificável associado ao ensino de línguas.

  10. Astrophysics of Red Supergiants

    Science.gov (United States)

    Levesque, Emily M.

    2017-12-01

    'Astrophysics of Red Supergiants' is the first book of its kind devoted to our current knowledge of red supergiant stars, a key evolutionary phase that is critical to our larger understanding of massive stars. It provides a comprehensive overview of the fundamental physical properties of red supergiants, their evolution, and their extragalactic and cosmological applications. It serves as a reference for researchers from a broad range of fields (including stellar astrophysics, supernovae, and high-redshift galaxies) who are interested in red supergiants as extreme stages of stellar evolution, dust producers, supernova progenitors, extragalactic metallicity indicators, members of massive binaries and mergers, or simply as compelling objects in their own right. The book is accessible to a range of experience levels, from graduate students up to senior researchers.

  11. Red - take a closer look.

    Directory of Open Access Journals (Sweden)

    Vanessa L Buechner

    Full Text Available Color research has shown that red is associated with avoidance of threat (e.g., failure or approach of reward (e.g., mating depending on the context in which it is perceived. In the present study we explored one central cognitive process that might be involved in the context dependency of red associations. According to our theory, red is supposed to highlight the relevance (importance of a goal-related stimulus and correspondingly intensifies the perceivers' attentional reaction to it. Angry and happy human compared to non-human facial expressions were used as goal-relevant stimuli. The data indicate that the color red leads to enhanced attentional engagement to angry and happy human facial expressions (compared to neutral ones - the use of non-human facial expressions does not bias attention. The results are discussed with regard to the idea that red induced attentional biases might explain the red-context effects on motivation.

  12. High-resolution Spectroscopic Observations of Single Red Giants in Three Open Clusters: NGC 2360, NGC 3680, and NGC 5822

    Science.gov (United States)

    Peña Suárez, V. J.; Sales Silva, J. V.; Katime Santrich, O. J.; Drake, N. A.; Pereira, C. B.

    2018-02-01

    Single stars in open clusters with known distances are important targets in constraining the nucleosynthesis process since their ages and luminosities are also known. In this work, we analyze a sample of 29 single red giants of the open clusters NGC 2360, NGC 3680, and NGC 5822 using high-resolution spectroscopy. We obtained atmospheric parameters, abundances of the elements C, N, O, Na, Mg, Al, Ca, Si, Ti, Ni, Cr, Y, Zr, La, Ce, and Nd, as well as radial and rotational velocities. We employed the local thermodynamic equilibrium atmospheric models of Kurucz and the spectral analysis code MOOG. Rotational velocities and light-element abundances were derived using spectral synthesis. Based on our analysis of the single red giants in these three open clusters, we could compare, for the first time, their abundance pattern with that of the binary stars of the same clusters previously studied. Our results show that the abundances of both single and binary stars of the open clusters NGC 2360, NGC 3680, and NGC 5822 do not have significant differences. For the elements created by the s-process, we observed that the open clusters NGC 2360, NGC 3680, and NGC 5822 also follow the trend already raised in the literature that young clusters have higher s-process element abundances than older clusters. Finally, we observed that the three clusters of our sample exhibit a trend in the [Y/Mg]-age relation, which may indicate the ability of the [Y/Mg] ratio to be used as a clock for the giants. Based on the observations made with the 2.2 m telescope at the European Southern Observatory (La Silla, Chile) under an agreement with Observatório Nacional and under an agreement between Observatório Nacional and Max-Planck Institute für Astronomie.

  13. Geographic distribution of genetic diversity in populations of Rio Grande Chub Gila pandora

    Science.gov (United States)

    Galindo, Rene; Wilson, Wade; Caldwell, Colleen A.

    2016-01-01

    In the southwestern United States (US), the Rio Grande chub (Gila pandora) is state-listed as a fish species of greatest conservation need and federally listed as sensitive due to habitat alterations and competition with non-native fishes. Characterizing genetic diversity, genetic population structure, and effective number of breeders will assist with conservation efforts by providing a baseline of genetic metrics. Genetic relatedness within and among G. pandora populations throughout New Mexico was characterized using 11 microsatellite loci among 15 populations in three drainage basins (Rio Grande, Pecos, Canadian). Observed heterozygosity (HO) ranged from 0.71–0.87 and was similar to expected heterozygosity (0.75–0.87). Rio Ojo Caliente (Rio Grande) had the highest allelic richness (AR = 15.09), while Upper Rio Bonito (Pecos) had the lowest allelic richness (AR = 6.75). Genetic differentiation existed among all populations with the lowest genetic variation occurring within the Pecos drainage. STRUCTURE analysis revealed seven genetic clusters. Populations of G. pandora within the upper Rio Grande drainage (Rio Ojo Caliente, Rio Vallecitos, Rio Pueblo de Taos) had high levels of admixture with Q-values ranging from 0.30–0.50. In contrast, populations within the Pecos drainage (Pecos River and Upper Rio Bonito) had low levels of admixture (Q = 0.94 and 0.87, respectively). Estimates of effective number of breeders (N b ) varied from 6.1 (Pecos: Upper Rio Bonito) to 109.7 (Rio Grande: Rio Peñasco) indicating that populations in the Pecos drainage are at risk of extirpation. In the event that management actions are deemed necessary to preserve or increase genetic diversity of G. pandora, consideration must be given as to which populations are selected for translocation.

  14. As Redes Sociais no Sector primário

    OpenAIRE

    Areias, Marcos André Caetano

    2013-01-01

    Dissertação apresentada como requisito parcial para obtenção do grau de Mestre em Estatística e Gestão de Informação A dissertação que de seguida será apresentada enquadra-se no âmbito da importância das redes sociais, enquanto factor de utilização e de trabalho no sector primário. Como tal, tem como objectivo estudar e aprofundar o conhecimento da utilização das redes sociais no sector primário. Desta forma, a dissertação foca-se no estudo das redes sociais no sector primário de três p...

  15. Neoplasmas do sistema urinário em 113 cães

    OpenAIRE

    Inkelmann,Maria Andréia; Kommers,Glaucia Denise; Fighera,Rafael A.; Irigoyen,Luiz Francisco; Barros,Claudio S.L.; Silveira,Isadora P.; Trost,Maria Elisa

    2011-01-01

    Foram revisados 4.723 protocolos de necropsias de cães realizadas entre janeiro de 1990 e julho de 2010 no LPV-UFSM. Os principais objetivos deste estudo retrospectivo foram determinar a prevalência e os tipos de neoplasmas que ocorreram no sistema urinário. Em 113 (2,4%) dos cães necropsiados, foram diagnosticados 27 neoplasmas primários e 86 metastáticos ou como parte de tumores multicêntricos no sistema urinário. Dos neoplasmas primários, a grande maioria teve origem epitelial. Treze casos...

  16. Growth and replication of red rain cells at 121°C and their red fluorescence

    Science.gov (United States)

    Gangappa, Rajkumar; Wickramasinghe, Chandra; Wainwright, Milton; Kumar, A. Santhosh; Louis, Godfrey

    2010-09-01

    We have shown that the red cells found in the Red Rain (which fell on Kerala, India, in 2001) survive and grow after incubation for periods of up to two hours at 121°C . Under these conditions daughter cells appear within the original mother cells and the number of cells in the samples increases with length of exposure to 121°C. No such increase in cells occurs at room temperature, suggesting that the increase in daughter cells is brought about by exposure of the Red Rain cells to high temperatures. This is an independent confirmation of results reported earlier by two of the present authors, claiming that the cells can replicate under high pressure at temperatures upto 300°C. The flourescence behaviour of the red cells is shown to be in remarkable correspondence with the extended red emission observed in the Red Rectagle planetary nebula and other galactic and extragalactic dust clouds, suggesting, though not proving an extraterrestrial origin.

  17. Red alder potential in Alaska

    Science.gov (United States)

    Allen Brackley; David Nicholls; Mike Hannan

    2010-01-01

    Over the past several decades, red alder has established itself as a commercially important species in the Pacific Northwest. Once considered a weed species, red alder now commands respect within many markets, including furniture, architectural millwork, and other secondary manufactured products. Although red alder's natural range extends to southeast Alaska, an...

  18. Nonlinear analysis of RED - a comparative study

    International Nuclear Information System (INIS)

    Jiang Kai; Wang Xiaofan; Xi Yugeng

    2004-01-01

    Random Early Detection (RED) is an active queue management (AQM) mechanism for routers on the Internet. In this paper, performance of RED and Adaptive RED are compared from the viewpoint of nonlinear dynamics. In particular, we reveal the relationship between the performance of the network and its nonlinear dynamical behavior. We measure the maximal Lyapunov exponent and Hurst parameter of the average queue length of RED and Adaptive RED, as well as the throughput and packet loss rate of the aggregate traffic on the bottleneck link. Our simulation scenarios include FTP flows and Web flows, one-way and two-way traffic. In most situations, Adaptive RED has smaller maximal Lyapunov exponents, lower Hurst parameters, higher throughput and lower packet loss rate than that of RED. This confirms that Adaptive RED has better performance than RED

  19. Nonlinear analysis of RED - a comparative study

    Energy Technology Data Exchange (ETDEWEB)

    Jiang Kai; Wang Xiaofan E-mail: xfwang@sjtu.edu.cn; Xi Yugeng

    2004-09-01

    Random Early Detection (RED) is an active queue management (AQM) mechanism for routers on the Internet. In this paper, performance of RED and Adaptive RED are compared from the viewpoint of nonlinear dynamics. In particular, we reveal the relationship between the performance of the network and its nonlinear dynamical behavior. We measure the maximal Lyapunov exponent and Hurst parameter of the average queue length of RED and Adaptive RED, as well as the throughput and packet loss rate of the aggregate traffic on the bottleneck link. Our simulation scenarios include FTP flows and Web flows, one-way and two-way traffic. In most situations, Adaptive RED has smaller maximal Lyapunov exponents, lower Hurst parameters, higher throughput and lower packet loss rate than that of RED. This confirms that Adaptive RED has better performance than RED.

  20. A Percepção sobre Carreira dos Funcionários de uma Empresa Automotiva do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Angela Beatriz Busato Garay

    2012-11-01

    Full Text Available Os estudos sobre carreira têm se mostrado relevantes na área de gestão de pessoas, entretanto, a maioria das pesquisas relativas ao tema é voltada a gerentes e diretores de grandes corporações.  Este artigo, por sua vez, tem como objetivo conhecer a percepção sobre carreira de funcionários das áreas administrativa e de produção de uma empresa automotiva situada na região metropolitana de Porto Alegre, Rio Grande do Sul. Esta pesquisa, com abordagem qualitativa, caracteriza-se como um estudo de caso de natureza exploratório-descritiva. O quadro teórico utilizado contempla o contexto histórico das teorias de carreira, suas concepções e significados e sua gestão. Para obtenção dos dados, utilizaram-se entrevistas semiestruturadas, realizadas com doze funcionários. A escolha dos respondentes considerou que eles não ocupassem cargos de gerência ou direção na organização, bem como seu nível de escolaridade. Os dados obtidos foram analisados quanto ao conteúdo e revelaram que a maioria dos entrevistados entende carreira como sinônimo de evolução ou ascensão profissional. Esses funcionários, de níveis hierárquicos inferiores, relacionam sua permanência na organização ao oferecimento de possibilidades de satisfação pessoal, crescimento e motivação profissional.

  1. Laboratório químico-prático do Rio de Janeiro: primeira tentativa de difusão da Química no Brasil (1812- 1819)

    OpenAIRE

    Santos Nadja Paraense dos

    2004-01-01

    Until the present date, historians of science have described inaccurately the first laboratory created in Brazil for establishing and divulging Chemistry, namely the "Laboratório Químico-Prático do Rio de Janeiro". During recent research carried out in the Arquivo do Museu Imperial (Petrópolis, RJ), I localized a document entitled "Ensaio histórico analítico das operações do Laboratório Químico-Prático do Rio de Janeiro", which allowed me to gain the relevant information to correct some of th...

  2. Primeiro registro de Chara indica e Chara zeylanica (Charophyceae, Charales, Characeae em reservatórios do semiárido do estado do Rio Grande do Norte, Brasil

    Directory of Open Access Journals (Sweden)

    Gustavo Henrique Gonzaga da Silva

    2013-04-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2013v26n3p243 No presente trabalho, apresentamos os primeiros registros das macroalgas Chara indica e Chara zeylanica para o estado do Rio Grande do Norte, Brasil, e para o semiárido nordestino. Exemplares de C. indica e C. zeylanica foram coletados nos reservatórios de Santa Cruz e Umari, respectivamente. Ambos os reservatórios estão localizados na bacia hidrográfica do Rio Apodi-Mossoró (oeste do estado, estando inseridos no bioma Caatinga.

  3. Segunda Guerra Mundial, Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Ricardo de Souza Rocha

    2007-01-01

    Full Text Available The purpose of this paper is to analyze the National Memorial to the World War II Dead (1956-60, a monument designed by Marcos Konder Netto and Hélio Ribas Marinho, and located in Flamengo Park, Rio de Janeiro. We start by commenting on the debates that were going on within the Modernist movement about the need for a new monumentality. Then, we examine the memorial against the urban landscape of Rio de Janeiro and its specific architectural language. Finally, we make an effort to explain the apparent paradox found in modern monuments.

  4. RIO Country Report 2015

    DEFF Research Database (Denmark)

    Grimpe, Christoph; Mitchell, Jessica

    The 2015 series of RIO Country Reports analyse and assess the policy and the national research and innovation system developments in relation to national policy priorities and the EU policy agenda with special focus on ERA and Innovation Union. The executive summaries of these reports put forward...

  5. Resíduos de pesticidas em sedimento de fundo de rio na Bacia Hidrográfica do Rio Cuiabá, Mato Grosso, Brasil

    Directory of Open Access Journals (Sweden)

    Juliana Possavatz

    2014-01-01

    Full Text Available O rio Cuiabá é um importante tributário do rio Paraguai, cuja bacia é de grande importância por agasalhar o Pantanal, a maior área úmida do planeta. A base econômica da bacia hidrográfica do rio Cuiabá é a produção agrícola e pecuária que, para manter elevada produtividade, requer grandes quantidades de insumos agrícolas como os pesticidas que, podem atingir diversos ambientes devido aos processos de dispersão que ocorrem após sua introdução no ambiente. Os sedimentos desempenham importante papel para a caracterização da poluição de rios devido a seu potencial de acumulação de poluentes. Este estudo objetivou avaliar a contaminação por pesticidas usados nas lavouras plantadas na bacia do rio Cuiabá, MT. Para tanto, amostras de sedimento de fundo foram coletadas mensalmente de agosto de 2011 a julho de 2012. Para a determinação dos pesticidas atrazina, cipermetrina, clorpirifós, endossulfam (α, β e seu metabólito endossulfam sulfato, lambda-cialotrina, malationa, metolacloro, metribuzim, parationa metílica, permetrina e trifuralina no sedimento utilizou-se método multirresíduo que consiste na extração sólido-líquido por agitação mecânica seguida de purificação por extração líquido-líquido e identificação e quantificação por cromatografia a gás acoplada a espectrometria de massas. Resíduos de pesticidas foram identificados em amostras coletadas em agosto e setembro de 2011 e janeiro, fevereiro, abril e julho de 2012, em concentrações variando de 5,7 a 79,3 µg kg-1 . Embora a frequência de detecção tenha sido baixa, esses resultados indicam que há potencial de transporte de pesticidas usados na bacia do rio Cuiabá e seus tributários atingindo o Pantanal.

  6. USO DE RESERVATÓRIOS DOMICILIARES E CONHECIMENTO DA POPULAÇÃO

    Directory of Open Access Journals (Sweden)

    Juliana Alvares Duarte Bonini CAMPOS

    2009-07-01

    Full Text Available

    A água destinada ao consumo humano deve ser adequada para a manutenção da saúde e para isso não só o tratamento mas também o armazenamento da água deve ser realizado de maneira adequada. Como os reservatórios domiciliares podem atuar como fator deteriorador, realizou-se um inquérito com 74 moradores da cidade de Araraquara visando obter informaçãoes sobre o conhecimento da finalidade e os cuidados despendidos à limpeza dos reservatórios. Os resultados monstraram que 67,6% dos entrevistados conheciam a finalidade dos reservatórios e apenas 59,5% realizavam limpeza periódica. Apesar de 94,6% saberem da necessidade das limpezas 40% justificaram não fazê-las devido as dificuldades de acesso e 53,3% por outros motivos. A classe social foi estimada através de questionário padrão e os dados obtidos avaliados estatisticamente. Dos cruzamentos apenas o estado de conservação do reservatório por classe social foi significativo. Os resutados demonstram portanto que os cuidados necessários à manutenção da qualidade da água não estão sendo observados e que campanhas de informação e esclarecimento devem ser realizadas para evitar a deterioração da qualidade da água armazenada nos reservatórios domiciliares. PALAVRAS-CHAVE: Reservatório domiciliar e qualidade da água.

  7. A atuação do Observatório Nacional registrada nos relatórios ministeriais 1889 a 1930

    Science.gov (United States)

    Rodrigues, T.

    2003-08-01

    O período republicano até 1930 foi marcante na história do Observatório Nacional. Diversas reformas levaram a instituição a três ministérios diferentes e mudaram a ênfase do seu trabalho. A tão aguardada mudança para uma nova sede, em São Cristóvão, em 1920, não foi suficiente para que a instituição acompanhasse o ritmo tomado pela astronomia no mundo e se firmasse como ambiente de pesquisa. Uma análise simplificada poderia caracterizar um período de produção científica insignificante, dado o distanciamento da instituição dos novos rumos da astrofísica e da rápida inovação dos instrumentos, além do pequeno volume de publicações. Era uma época em que ainda não existiam os mecanismos formais de apoio e avaliação da atividade científica. Esse trabalho procura identificar a real atividade do Observatório no conteúdo dos Relatórios Ministeriais que, ao final de cada ano, apresentava as atividades, sucessos e problemas enfrentados pela instituição. Questões como instrumental e recursos humanos necessários; entraves burocráticos e financeiros; e articulações com outros observatórios se complementaram entre si ao longo desses anos para definir o perfil institucional e alguns aspectos fundamentais para a construção da astronomia no país. É possível concluir que a ênfase em serviços geográficos e de meteorologia, ao lado da inadequação dos instrumentos e do local, quase fizeram desaparecer a pesquisa em astronomia. Porém, vale destacar a sobrevivência de alguns trabalhos, como, por exemplo, variação de latitude e observação de estrelas duplas que mantiveram importante intercâmbio com outros grupos de pesquisa, demonstrando o constante esforço dos astrônomos e das diretorias em defesa da atividade científica.

  8. A introdução da matemática moderna no Ciclo Preparatório do Ensino Secundário em Portugal

    OpenAIRE

    Bento, Marta Alexandra Marques

    2012-01-01

    Dissertação para obtenção do Grau de Mestre em Ensino da Matemática Com o presente estudo pretende-se estudar a introdução do programa de Matemática Moderna no contexto da criação do novo Ciclo Preparatório do Ensino Secundário, através da visão do Inspetor Joaquim Simões Redinha, sendo por isso necessário reunir e digitalizar documentação relativa aos primeiros anos do referido ciclo e obter notas sobre o percurso profissional e perspetivas do supramencionado inspetor. Pretende-se aind...

  9. Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit juice) profiles of celiprolol following the oral microdose and therapeutic dose.

    Science.gov (United States)

    Ieiri, Ichiro; Doi, Yohei; Maeda, Kazuya; Sasaki, Tomohiro; Kimura, Miyuki; Hirota, Takeshi; Chiyoda, Takeshi; Miyagawa, Mayuko; Irie, Shin; Iwasaki, Kazuhide; Sugiyama, Yuichi

    2012-07-01

    The authors evaluated the contribution of the SLCO2B1 polymorphism to the pharmacokinetics of celiprolol at a microdose (MD) and therapeutic dose (TD) and compared pharmacokinetic proportionality between the 2 dose forms in 30 SLCO2B1 genotype-matched healthy volunteers. Three drugs (celiprolol, fexofenadine, and atenolol) were orally administered as a cassette dosing following the MD (totally 97.5 µg) and then a TD (100 mg) of celiprolol, with and without grapefruit juice. The mean AUC(0-24) of celiprolol was lower in SLCO2B1*3/*3 individuals (775 ng·h/mL) than in *1/*3 (1097 ng·h/mL) and *1/*1 (1547 ng·h/mL) individuals following the TD, and this was confirmed in population pharmacokinetic analysis with statistical significances; however, SLCO2B1 genotype-dependent differences disappeared following the MD. Dose-normalized AUC of celiprolol at the MD was much lower than that at the TD, explained by the saturation of the efflux transporter. Thus, the effect of SLCO2B1 polymorphism on the AUC of celiprolol clearly observed only at the TD may be due to the saturation of the efflux transport systems.

  10. Violência e sofrimento social no itinerário de travestis de Santa Maria, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Martha Helena Teixeira de Souza

    2015-04-01

    Full Text Available No ano de 2012, realizamos pesquisa etnográfica com travestis de Santa Maria, Rio Grande do Sul, Brasil, por meio de observação participante, entrevistas e acompanhamento de suas vidas cotidianas. Durante esse período, percebemos que as violências física e simbólica e o sofrimento delas decorrentes eram invariantes, condição com a qual tinham que lidar em seus itinerários, em suas práticas e afazeres diários. Este artigo discute as violências vivenciadas nas trajetórias percorridas pelas travestis (família, escola, delegacias, serviços de saúde, procurando, sobretudo, compreender como tais violências estão relacionadas às experiências nos serviços de saúde e como os serviços de saúde por elas acessados reagiram às violências.

  11. HEMOPARASITOS DE PIRANHAS VERMELHAS PYGOCENTRUS NATTERERI (KNER, 1858 (CHARACIFORMES: CHARACIDAE CAPTURADAS NA REGIÃO DO MÉDIO RIO ARAGUAIA, ESTADO DE GOIÁS, GO

    Directory of Open Access Journals (Sweden)

    Isabela Vieira Carneiro

    2016-07-01

    Full Text Available This work aimed to evaluate blood smears of 128 red piranha specimens Pygocentrus nattereri (Kner, 1858 (Characiformes: Characidae as for the presence of hemoparasites and blood cells that were visualized. Samples were collected in Rio Vermelho (Red River (15°10'44.73''S and 51°09'55.83W'', in the Brazilian state of Goiás, between April 2012 and August 2013, including ebb, full and dry phases. After identificating and numbering the piranhas, we collected approximately 0.5 mL of blood from each animal, from the caudal vein or through intracardiac puncture, and two blood smears were done and stained with May GrünwaldGiemsa and Fast Panoptic stains. After euthanasia, the body mass and biometrics of every fish were measured. Abiotic factors of the river water were also analyzed, such as temperature and transparency. In general, the biometric parameters were higher in the full phase of the river, and the values obtained on water quality were similar in relation to the average temperature of the water, which was around 82,4°F. The average transparency of the water varied, being greater at low tide. Erythrocytes, thrombocytes, neutrophils, eosinophils, monocytes, heterophile and lymphocytes were identified as blood cells of red piranhas and hemogregarines have been found in about 25% (32/128 of the blood smears.

  12. Análise de uma iniciativa de valorização de rios e lagoas em áreas urbanas: Programa Águas do rio (Guardiões dos rios).

    OpenAIRE

    Andreia Cardoso da Silva

    2009-01-01

    A preocupação com recursos hídricos tem sido crescente em meios urbanos. O despejo de resíduos sólidos em rios é comum por populações ribeirinhas, favorecendo a ocorrência de enchentes, a proliferação de vetores e doenças e o desprezo da comunidade pelos rios. Nesse contexto, programas que relacionam lixo, recursos hídricos e população ribeirinha têm sido objeto de várias iniciativas governamentais. Este trabalho busca avaliar uma delas: o Programa Municipal de valorização de r...

  13. Edible Coating Using a Chitosan-Based Colloid Incorporating Grapefruit Seed Extract for Cherry Tomato Safety and Preservation.

    Science.gov (United States)

    Won, Jin Sung; Lee, Seung Jo; Park, Hyeon Hwa; Song, Kyung Bin; Min, Sea C

    2018-01-01

    Grapefruit seed extract (GSE)-containing chitosan-based coating was developed and applied to cherry tomatoes to protect them from Salmonella invasion and improve their storability. The coating colloids were produced by mixing a chitosan colloid (1% [w/w] chitosan) with GSE at various concentrations (0.5%, 0.7%, 1.0%, and 1.2% [w/w]) using high-shear mixing (10000 rpm, 2 min). Coatings with chitosan colloids containing GSE at 0.0%, 0.5%, 0.7%, and 1.0% (w/w) inactivated Salmonella on cherry tomatoes by 1.0 ± 0.3, 1.2 ± 0.3, 1.6 ± 0.1, and 2.0 ± 0.3 log CFU/cherry tomato, respectively. Coatings both with and without GSE (1.0%) effectively inhibited the growth of Salmonella and total mesophilic aerobes, reduced CO 2 generation, and retarded titratable acidity decrease during storage at 10 and 25 °C. The advantage of incorporating GSE in the formulation was demonstrated by delayed microorganism growth and reduced weight loss at 25 °C. The chitosan-GSE coating did not affect lycopene concentration, color, and sensory properties (P > 0.05). Chitosan-GSE coating shows potential for improving the microbiological safety and storability of cherry tomatoes, with stronger efficacy at 25 °C than that of chitosan coating without GSE. A novel chitosan coating containing grape fruit seed extract (GSE) improved the microbiological safety against Salmonella and storability of cherry tomatoes without altering their flavor, demonstrating its strong potential as an effective postharvest technology. Chitosan coating containing GSE might be preferable over chitosan coating without GSE for application to tomatoes that are stored at room temperature in that it more effectively inhibits microbial growth and weight loss than the coating without GSE at 25 °C. © 2017 Institute of Food Technologists®.

  14. Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.

    Science.gov (United States)

    Murase, Takatoshi; Misawa, Koichi; Haramizu, Satoshi; Minegishi, Yoshihiko; Hase, Tadashi

    2010-08-01

    AMP-activated protein kinase (AMPK) is a serine/threonine kinase that is implicated in the control of energy metabolism and is considered to be a molecular target for the suppression of obesity and the treatment of metabolic syndrome. Here, we identified and characterized nootkatone, a constituent of grapefruit, as a naturally occurring AMPK activator. Nootkatone induced an increase in AMPKalpha1 and -alpha2 activity along with an increase in the AMP/ATP ratio and an increase the phosphorylation of AMPKalpha and the downstream target acetyl-CoA carboxylase (ACC), in C(2)C(12) cells. Nootkatone-induced activation of AMPK was possibly mediated both by LKB1 and Ca(2+)/calmodulin-dependent protein kinase kinase. Nootkatone also upregulated PPARgamma coactivator-1alpha in C(2)C(12) cells and C57BL/6J mouse muscle. In addition, administration of nootkatone (200 mg/kg body wt) significantly enhanced AMPK activity, accompanied by LKB1, AMPK, and ACC phosphorylation in the liver and muscle of mice. Whole body energy expenditure evaluated by indirect calorimetry was also increased by nootkatone administration. Long-term intake of diets containing 0.1% to 0.3% (wt/wt) nootkatone significantly reduced high-fat and high-sucrose diet-induced body weight gain, abdominal fat accumulation, and the development of hyperglycemia, hyperinsulinemia, and hyperleptinemia in C57BL/6J mice. Furthermore, endurance capacity, evaluated as swimming time to exhaustion in BALB/c mice, was 21% longer in mice fed 0.2% nootkatone than in control mice. These findings indicate that long-term intake of nootkatone is beneficial toward preventing obesity and improving physical performance and that these effects are due, at least in part, to enhanced energy metabolism through AMPK activation in skeletal muscle and liver.

  15. 21 CFR 640.10 - Red Blood Cells.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Red Blood Cells. 640.10 Section 640.10 Food and... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Red Blood Cells § 640.10 Red Blood Cells. The proper name of this product shall be Red Blood Cells. The product is defined as red blood cells remaining...

  16. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the substantiation of a health claim related to a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf chard, red Swiss chard, golden Swiss chard

    DEFF Research Database (Denmark)

    Tetens, Inge

    related to a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf chard, red Swiss chard, golden Swiss chard and white Swiss chard and maintenance of normal blood cholesterol concentration. The food that is the subject of the health claim, a combination of red...... spinach (Spinacia oleracea L.), green spinach (Spinacia oleracea L.), red chicory (Cichorium intybus L.), green chicory (Cichorium intybus L.), green leaf chard (Beta vulgaris L. var. cicla), red leaf chard (Beta vulgaris L. var. cicla), red Swiss chard (Beta vulgaris L. var. cicla), golden Swiss chard...... for the scientific substantiation of the claim were provided by the applicant. The Panel concludes that a cause and effect relationship has not been established between consumption of a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf chard, red Swiss chard, golden...

  17. Crianças em situação de violência de um ambulatório do Rio de Janeiro: conhecendo seu perfil

    OpenAIRE

    Pierantoni, Lucia Martins de Magalhães; Cabral, Ivone Evangelista

    2009-01-01

    Buscou-se caracterizar as crianças envolvidas em situação de violência e seus familiares, e analisar o papel social do agressor/protetor no círculo da violência. Estudo quantitativo descritivo foi desenvolvido no Ambulatório da Família de um Hospital do Rio de Janeiro, entre 2006 e 2007. Dados do prontuário de 44 crianças demonstraram intensa relação entre pobreza, baixa escolaridade e gênero na matriz social da violência. Houve maior registro de meninos (64%) expostos a violência do que meni...

  18. Estruturação elusiva de atos e negócios jurídicos no direito tributário brasileiro: limites ao planejamento tributário 

    OpenAIRE

    Leonardo Aguirra de Andrade

    2014-01-01

    O presente estudo analisa os contornos da estruturação elusiva de atos e negócios jurídicos no Direito Tributário brasileiro. Inicialmente, busca-se definir o conceito de planejamento tributário, abordando as diferentes noções de elisão fiscal, elusão fiscal e evasão fiscal, bem como os critérios contemplados pela doutrina brasileira de Direito Tributário para distinguir as condutas oponíveis e inoponíveis ao Fisco. Para melhor compreensão dos limites da conduta elusiva, examinam-se os princí...

  19. Para que servem os inventários de fauna?

    Directory of Open Access Journals (Sweden)

    Luís Fábio Silveira

    2010-01-01

    Full Text Available Inventários de fauna acessam diretamente a diversidade de uma localidade, em um determinado espaço e tempo. Os dados primários gerados pelos inventários compõem uma das ferramentas mais importantes na tomada de decisões a respeito do manejo de áreas naturais. Entretanto, vários problemas têm sido observados em diversos níveis relacionados aos inventários de fauna no Brasil e vão desde a formação de recursos humanos até a ausência de padronização, de desenho experimental e de seleção de métodos inadequados. São apresentados estudos de caso com mamíferos, répteis, anfíbios e peixes, nos quais são discutidos problemas como variabilidade temporal e métodos para detecção de fauna terrestre, sugerindo que tanto os inventários quanto os programas de monitoramento devam se estender por prazos maiores e que os inventários devem incluir diferentes metodologias para que os seus objetivos sejam plenamente alcançados.Inventories of fauna directly access the diversity of a locality in a certain period of time. The primary data generated by these inventories comprise one of the most important steps in decisions making regarding the management of natural areas. However, several problems have been observed at different levels related to inventories of fauna in Brazil, and range from the training of humans to the lack of standardization of experimental design and selection of inappropriate methods. We present case studies of mammals, reptiles, amphibians and fishes, where they discussed issues such temporal variability and methods for detection of terrestrial fauna, suggesting that both inventories and monitoring programs should be extended for longer terms and that inventories should include different methodologies to ensure that their goals are fully achieved.

  20. Physical properties of Gelidium corneum-gelatin blend films containing grapefruit seed extract or green tea extract and its application in the packaging of pork loins.

    Science.gov (United States)

    Hong, Y-H; Lim, G-O; Song, K B

    2009-01-01

    Edible Gelidium corneum-gelatin (GCG) blend films containing grapefruit seed extract (GFSE) or green tea extract (GTE) were manufactured, and the quality of pork loins packed with the film during storage was determined. Tensile strength (TS) and water vapor permeability (WVP) of the films containing GFSE or GTE were better than those of the control. The film's antimicrobial activity against Escherichia coli O157:H7 and Listeria monocytogenes increased with increasing antimicrobial concentration, resulting in a decrease in the populations of bacteria by 0.77 to 2.08 and 0.91 to 3.30 log CFU/g, respectively. Pork loin samples were inoculated with E. coli O157:H7 and L. monocytogenes. The samples packed with the GCG film containing GFSE (0.08%) or GTE (2.80%) had a decrease in the populations of E. coli O157:H7 and L. monocytogenes of 0.69 to 1.11 and 1.05 to 1.14 log CFU/g, respectively, compared to the control after 4 d of storage. The results showed that the quality of pork loins during storage could be improved by packaging them with the GCG film containing GFSE or GTE.

  1. Meliponiculture in Rio Grande do Norte

    Directory of Open Access Journals (Sweden)

    Ulysses Madureira Maia

    2015-12-01

    Full Text Available ABSTRACT. Maia U.M., Jaffe R., Carvalho A.T. & Imperatriz-Fonseca V.L. [Meliponiculture in Rio Grande do Norte.] Meliponicultura no Rio Grande do Norte. Revista Brasileira de Medicina Veterinária, 37(4:327-333, 2015. Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, SP 14040-901, Brasil. E-mail: ummaia@usp.br This study aimed to assess the current status of stingless bee beekeeping (meliponiculture in the State of Rio Grande do Norte, Brazil, with the aid of structured questionnaires made during visits to beekeepers. The results were compared with a previous census made in the state and with a similar study from Australia. Meliponiculture in Rio Grande do Norte is still informal and little standardized. The activity has grown in recent years considering the mean number of nests per beekeeper. Most apiaries are formed of up to 50 colonies, usually distributed in the backyards of homes. Twelve species of stingless bees were reared in the state, and the most common was the “Jandaíra” bee (Melipona subnitida, whose honey is considered medicinal. While many beekeepers already know the importance of bees as pollinators, stingless bees are still not used for crop pollination. Compared to a recent analysis of beekeeping in Australia, meliponiculture in Brazil is more traditional, honey is the main product and the number of colonies per beekeeper is much higher. Our results highlight the need to reinforce knowledge about bees and promote specific training aimed at improving and standardizing management practices.

  2. “ÁGUA VIRA SAL LÁ NA SALINA”: O GLOSSÁRIO DOS TERMOS DO SAL NO RIO GRANDE DO NORTE NUMA PERSPECTIVA SOCIOTERMINOLÓGICA

    Directory of Open Access Journals (Sweden)

    Moisés Batista da Silva

    2016-01-01

    Full Text Available O presente trabalho tem como objetivo apresentarresultados da pesquisa sobre os termos usados na Indústriado sal, em três municípios que fazem parte da região salineirado Rio Grande do Norte. Primeiramente, abordamosas diferentes ciências do Léxico estudadas por Boutin--Quesnel (1985, Barbosa (1994,1995, Barros (2004,dando ênfase maior nas orientações teórico-metodológicasda Socioterminologia (FAULSTICH, 1995, 1996, 1998,2006. Em seguida, expomos os procedimentos tanto dametodologia de campo quanto da metodologia da organizaçãodo Glossário da Terminologia do Sal - GLOSSAL(SILVA, 2007. Depois, apresentamos uma amostra dosverbetes, as análises feitas a partir desse repertório e, porfim, as considerações finais quanto aos fatos linguísticos,observados nesse glossário. Desse modo, essa pesquisa sejustifica por possibilitar a divulgação de um produto terminográficodestinado, não só aos especialistas e pesquisadoresdas Ciências do Léxico, como também ao grandepúblico e aos interessados em aprofundar seus estudos naterminologia do sal.Palavras-chave: Sal. Indústria do Sal. Terminologia. Socioterminologia.Glossário.

  3. NMR water-proton spin-lattice relaxation time of human red blood cells and red blood cell suspensions

    International Nuclear Information System (INIS)

    Sullivan, S.G.; Rosenthal, J.S.; Winston, A.; Stern, A.

    1988-01-01

    NMR water-proton spin-lattice relaxation times were studied as probes of water structure in human red blood cells and red blood cell suspensions. Normal saline had a relaxation time of about 3000 ms while packed red blood cells had a relaxation time of about 500 ms. The relaxation time of a red blood cell suspension at 50% hematocrit was about 750 ms showing that surface charges and polar groups of the red cell membrane effectively structure extracellular water. Incubation of red cells in hypotonic saline increases relaxation time whereas hypertonic saline decreases relaxation time. Relaxation times varied independently of mean corpuscular volume and mean corpuscular hemoglobin concentration in a sample population. Studies with lysates and resealed membrane ghosts show that hemoglobin is very effective in lowering water-proton relaxation time whereas resealed membrane ghosts in the absence of hemoglobin are less effective than intact red cells. 9 refs.; 3 figs.; 1 table

  4. Sedimentation in Rio La Venta Canyon in Netzahualcoyotl Reservoir, Chiapas, Mexico

    Science.gov (United States)

    de La Fuente, J. A.; Lisle, T.; Velasquez, J.; Allison, B. L.; Miller, A.

    2002-12-01

    Sedimentation of Rio La Venta as it enters the Netzahualcoyotl Reservoir in Chiapas, Mexico, threatens a unique part of the aquatic ecosystem. Rio La Venta enters the reservoir via a narrow canyon about 16 km long with spectacular, near-vertical limestone bluffs up to 320 m high and inhabited by the flora and fauna of a pristine tropical forest. Karst terrain underlies most of the Rio La Venta basin in the vicinity of the reservoir, while deeply weathered granitic terrain underlies the Rio Negro basin, and the headwaters of the Rio La Venta to the south. The Rio Negro joins Rio La Venta 3 km downstream of the upper limit of the reservoir and delivers the bulk of the total clastic sediment (mostly sand and finer material). The canyon and much of the contributing basin lie within the Reserva de la Biosfera, Selva El Ocote, administered by the Comision Nacional de Areas Naturales Protegidas, part of the Secretaria de Medioambiente y Recursos Naturales. The Klamath National Forest Forest has cooperated with its Mexican counterparts since 1993 in natural resource management, neo-tropical bird inventories, wildfire management, and more recently in watershed analyses. Rates of sedimentation are estimated from bathymetric surveys conducted in March, 2002. A longitudinal profile down the inundated canyon during a high reservoir level shows an inflection from a slope of 0.0017 to one of 0.0075 at 7.2 km downstream of the mouth of Rio Negro. The bed elevation at this point corresponds to the lowest reservoir level, suggesting that the gentler sloping bed upstream is formed by fluvial processes during drawdown and that downstream by pluvial processes. Using accounts that boats could access Rio Negro during low water levels in 1984, we estimate an annual sedimentation rate of roughly 3 million cubic meters per year. This suggests that boats might no longer be able to access the most spectacular section of canyon upstream of Rio Negro within a decade, depending on how the

  5. Validade de indicadores de atividade física e comportamento sedentário da Pesquisa Nacional de Saúde do Escolar entre adolescentes do Rio de Janeiro, Brasil

    Directory of Open Access Journals (Sweden)

    Letícia Ferreira Tavares

    2014-09-01

    Full Text Available Analisou-se a validade relativa dos indicadores de atividade física do questionário utilizado na Pesquisa Nacional de Saúde do Escolar (PeNSE entre adolescentes da cidade do Rio de Janeiro, Brasil. Foram estudados 174 alunos. Avaliaram-se os seguintes indicadores referentes ao tempo semanal acumulado com a prática de atividade física: ATIVO-300MIN (acumulou 300 minutos ou mais; ATIVO-150MIN (acumulou 150 minutos ou mais; INATIVO (não praticou atividade física. Também foram estudados os indicadores de comportamento sedentário referentes ao tempo diário despendido assistindo TV, jogando videogame e usando computador. Foram comparados os resultados do questionário e dos três recordatórios de 24 horas. Os resultados de ATIVO-300MIN, ATIVO-150MIN e INATIVO gerados pela PeNSE apresentaram alta acurácia. Esses indicadores tiveram melhor desempenho que os de comportamento sedentário, tanto em relação às estimativas de frequência quanto em relação à sensibilidade, especificidade e índice de acurácia. Os indicadores de atividade física da PeNSE apresentaram validade relativa satisfatória.

  6. Indicação de exames pré-operatórios segundo critérios clínicos: necessidade de supervisão

    Directory of Open Access Journals (Sweden)

    Aline Pallaoro Garcia

    2014-01-01

    Full Text Available Justificativa e objetivos: a solicitação indiscriminada de exames complementares na avaliação pré-anestésica é comum na prática clínica e implica custos adicionais e a possibilidade de resultados falso-positivos. Os objetivos desta pesquisa foram analisar se os exames pré-operatórios em cirurgias eletivas são solicitados segundo critério clínico e avaliar os custos desnecessários para a instituição. Métodos: foram avaliadas as solicitações de exames pré-operatórios em pacientes adultos submetidos a cirurgias eletivas não cardíacas. Os exames foram solicitados pelos cirurgiões, conforme protocolo do Serviço de Anestesia. Foram avaliados dados demográficos, estado físico, comorbidades e tipo de exame complementar solicitado. Os exames feitos foram comparados com os exames indicados. O custo dos exames foi baseado na tabela Datasus. Resultados: foram avaliados 1.063 pacientes. Verificou-se que 41,9% dos exames feitos nos pacientes classificados como ASA I não estavam indicados. No grupo de risco ASA II foram feitos 442 exames (17,72% sem necessidade. Perceberam-se elevadas porcentagens na solicitação de hemograma, creatinina, coagulograma, raios X de tórax e ECG nos grupos ASA I-II. Apenas 40 (5,25% dos exames feitos no grupo ASA III não estavam indicados. Nos pacientes do grupo ASA IV, 22,5% dos exames necessários não foram feitos. Ressalta-se uma economia anual de 13% (R$1.923,13 caso os exames fossem feitos conforme o protocolo. Conclusões: os exames pré-operatórios nem sempre são solicitados de acordo com critérios clínicos, o que resulta em maiores custos para a instituição.

  7. The acute stress response of red porgy, Pagrus pagrus, kept on a red or white background

    NARCIS (Netherlands)

    Salm, A.L. van der; Pavlidis, M; Flik, G.; Wendelaar Bonga, S.E.

    2005-01-01

    The skin colour of red porgy, Pagrus pagrus, can be modified by exposure to different background colours. Red and white background colours brighten the dark skin colour that develops under common culture conditions in red porgy. To assess whether skin colour is also modified by aquaculture related

  8. Pós-colheita de mamão híbrido UENF/CALIMAN 01 cultivado no Rio Grande do Norte Postharvest shelf life of papaya UENF/CALIMAN 01 produced in Rio Grande do Norte

    Directory of Open Access Journals (Sweden)

    Patrícia Lígia Dantas de Morais

    2007-01-01

    was limited to the tests accomplished in commercial farms. This work purpose was to evaluate the hybrid UENF/Caliman shelf life produced in the state of Rio Grande Norte. Fruit were harvested at physiological maturity, packaged and transported to the Semi-arid Federal Rural University laboratory, in Mossoró City, state of Rio Grande do Norte . Fruits were stored at 25 ºC (±2 and 55 % (± 5 of relative humidity for 0, 2, 4, 6, 8 and 10 days. The experiment was completely randomized with 6 treatments. Were evaluated the variables: mass loss, external appearance, firmness, pulp color, titratable acidity, pH, soluble solids and total soluble sugars. The hybrid presents phenotypic characteristics of the 'Formosa' papaya group, with elongated fruits, 1,28 kg of medium mass, 2,74 cm of pulp thickness, red coloration of the pulp, high content of soluble solids (13,65% and sugars (10,53%. The quality variables analyzed limited at postharvest shelf life of the hybrid UENF/Caliman 01 to eight days.

  9. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the substantiation of a health claim related to a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf chard, red Swiss chard, golden Swiss chard

    DEFF Research Database (Denmark)

    Tetens, Inge

    related to a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf chard, red Swiss chard, golden Swiss chard and white Swiss chard and protection of blood lipids from oxidative damage. The food that is the subject of the health claim, a combination...... of the following frozen vegetables: red spinach (Spinacia oleracea L.), green spinach (Spinacia oleracea L.), red chicory (Cichorium intybus L.), green chicory (Cichorium intybus L.), green leaf chard (Beta vulgaris L. var. cicla), red leaf chard (Beta vulgaris L. var. cicla), red Swiss chard (Beta vulgaris L. var...... conclusions could be drawn for the scientific substantiation of the claim were provided by the applicant. The Panel concludes that a cause and effect relationship has not been established between consumption of a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf...

  10. Rio Chama Floodplain Management Study

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The Village of Chama requested the Soil Conservation Service, through the Upper Chama Soil and Water Conservation District, to conduct a study of the Rio Chama and...

  11. Energy balance of the Rio de Janeiro State - 1980/1994

    International Nuclear Information System (INIS)

    1995-01-01

    This document informs the energetic balance for Rio de Janeiro State -1980/1994, containing the energy fluxes from primary and secondary energy sources in the main sectors of Rio de Janeiro economy. 50 figs., 139 tabs

  12. A pertinência da arquitetura no marketing imobiliário

    OpenAIRE

    Silva, António Augusto Ferreira da

    2013-01-01

    Mestrado Integrado em Arquitectura Exame público realizado em 17 de Outubro de 2013 A habitação surge no mercado atual como um produto repetitivo na oferta e qualidade residencial, resultado da ausência de investigação por parte dos intervenientes no setor imobiliário, demonstrando uma abordagem pouco real das verdadeiras necessidades e desejos dos compradores do produto imobiliário. Num setor imobiliário cada vez mais competitivo, a análise da oferta habitacional torna-se fator esse...

  13. The Link between Protein Kinase CK2 and Atypical Kinase Rio1

    Directory of Open Access Journals (Sweden)

    Konrad Kubiński

    2017-02-01

    Full Text Available The atypical kinase Rio1 is widespread in many organisms, ranging from Archaebacteria to humans, and is an essential factor in ribosome biogenesis. Little is known about the protein substrates of the enzyme and small-molecule inhibitors of the kinase. Protein kinase CK2 was the first interaction partner of Rio1, identified in yeast cells. The enzyme from various sources undergoes CK2-mediated phosphorylation at several sites and this modification regulates the activity of Rio1. The aim of this review is to present studies of the relationship between the two different kinases, with respect to CK2-mediated phosphorylation of Rio1, regulation of Rio1 activity, and similar susceptibility of the kinases to benzimidazole inhibitors.

  14. Twitteratura: aproximando letramento literário e letramento digital

    Directory of Open Access Journals (Sweden)

    Vinicius Carvalho Pereira

    2017-07-01

    Full Text Available As práticas de letramento literário da escola brasileira voltam-se majoritariamente para textos em suporte impresso, embora parte significativa da produção literária contemporânea em língua portuguesa venha sendo feita em suporte eletrônico ou digital. Tal disjunção se deve, entre outros fatores, à predominância de obras canônicas no currículo escolar, à natureza impressa do livro didático e a um entendimento restrito do que seja o texto literário. Por outro lado, assistimos ao uso crescente de aparelhos celulares e smartphones em sala de aula, raramente articulado ao processo de ensino-aprendizagem, ainda que esses dispositivos possam integrar práticas de letramento literário na esfera digital. No presente artigo, discutem-se questões teórico-metodológicas acerca do uso, em sala de aula, de celulares e smartphones para o trabalho com um gênero literário emergente: a Twitteratura. Da página à tela, do ponto ao pixel, novos entendimentos do literário podem ser introduzidos no currículo escolar, propiciando uma compreensão mais ampla sobre as relações sobredeterminantes entre linguagem, sociedade e tecnologia.

  15. Next generation red teaming

    CERN Document Server

    Dalziel, Henry

    2015-01-01

    Red Teaming is can be described as a type of wargaming.In private business, penetration testers audit and test organization security, often in a secretive setting. The entire point of the Red Team is to see how weak or otherwise the organization's security posture is. This course is particularly suited to CISO's and CTO's that need to learn how to build a successful Red Team, as well as budding cyber security professionals who would like to learn more about the world of information security. Teaches readers how to dentify systemic security issues based on the analysis of vulnerability and con

  16. Processo sucessório na governança de organizações familiares: um estudo exploratório nas “Mehores Empresas"

    Directory of Open Access Journals (Sweden)

    Rodrigo Silva

    2014-05-01

    Full Text Available Este artigo se propõe a levantar práticas por meio das quais organizações familiaresenfrentam o desafio da sucessão dos seus profissionais. Para o cumprimento desseobjetivo foi realizada uma pesquisa exploratória de levantamento de práticas relativas aoplanejamento sucessório entre as Melhores Empresas para Você Trabalhar no Brasil. Como intuito de levantar as principais características do planejamento sucessório adotadas pelasorganizações familiares, foi realizada uma pesquisa de levantamento exploratória. Para arealização das análises do presente trabalho, foram consideradas as ações de Dutra (2010para estruturação do planejamento sucessório. Em síntese, a literatura evidencia que emboraa sucessão constitua evento de fundamental importância para a continuidade dos negócios esobrevivência das empresas familiares, ela poderá tornar-se traumática, se não for conduzidade forma racional, o que demonstra a necessidade de tal processo se desenvolver através deplanejamento cuidadoso e racional, que procure levar em conta a ampla gama de fatores queo afetam. No caso das empresas familiares, nota-se o desafio de considerar as questõesemocionais e afetivos na discussão do planejamento sucessório. Constatou-se pouca atençãoaos aspectos emocionais do processo sucessório nas organizações familiares.

  17. Aplicação do fluxo unitário da produção na manufatura do vestuário de moda

    OpenAIRE

    Chi Ming Wan

    2016-01-01

    O objetivo deste trabalho é discutir a aplicação do Fluxo Unitário da Produção (FUP) no processo de fabricação do vestuário de moda, com ênfase em produtos de moda feminina. Para tanto, foi realizada uma pesquisa de campo, por meio de estudo de caso, em empresa do setor. O resultado da pesquisa mostra que, apesar das particularidades do setor, como o baixo volume de produção, curto ciclo de vida do produto e grande diversidade de modelos, a aplicação do Fluxo Unitário da Produção na manufatur...

  18. Tests of two convection theories for red giant and red supergiant envelopes

    Science.gov (United States)

    Stothers, Richard B.; Chin, Chao-Wen

    1995-01-01

    Two theories of stellar envelope convection are considered here in the context of red giants and red supergiants of intermediate to high mass: Boehm-Vitense's standard mixing-length theory (MLT) and Canuto & Mazzitelli's new theory incorporating the full spectrum of turbulence (FST). Both theories assume incompressible convection. Two formulations of the convective mixing length are also evaluated: l proportional to the local pressure scale height (H(sub P)) and l proportional to the distance from the upper boundary of the convection zone (z). Applications to test both theories are made by calculating stellar evolutionary sequences into the red zone (z). Applications to test both theories are made by calculating stellar evolutionary sequences into the red phase of core helium burning. Since the theoretically predicted effective temperatures for cool stars are known to be sensitive to the assigned value of the mixing length, this quantity has been individually calibrated for each evolutionary sequence. The calibration is done in a composite Hertzsprung-Russell diagram for the red giant and red supergiant members of well-observed Galactic open clusters. The MLT model requires the constant of proportionality for the convective mixing length to vary by a small but statistically significant amount with stellar mass, whereas the FST model succeeds in all cases with the mixing lenghth simply set equal to z. The structure of the deep stellar interior, however, remains very nearly unaffected by the choices of convection theory and mixing lenghth. Inside the convective envelope itself, a density inversion always occurs, but is somewhat smaller for the convectively more efficient MLT model. On physical grounds the FST model is preferable, and seems to alleviate the problem of finding the proper mixing length.

  19. The IOC consensus statement: beyond the Female Athlete Triad--Relative Energy Deficiency in Sport (RED-S).

    Science.gov (United States)

    Mountjoy, Margo; Sundgot-Borgen, Jorunn; Burke, Louise; Carter, Susan; Constantini, Naama; Lebrun, Constance; Meyer, Nanna; Sherman, Roberta; Steffen, Kathrin; Budgett, Richard; Ljungqvist, Arne

    2014-04-01

    Protecting the health of the athlete is a goal of the International Olympic Committee (IOC). The IOC convened an expert panel to update the 2005 IOC Consensus Statement on the Female Athlete Triad. This Consensus Statement replaces the previous and provides guidelines to guide risk assessment, treatment and return-to-play decisions. The IOC expert working group introduces a broader, more comprehensive term for the condition previously known as 'Female Athlete Triad'. The term 'Relative Energy Deficiency in Sport' (RED-S), points to the complexity involved and the fact that male athletes are also affected. The syndrome of RED-S refers to impaired physiological function including, but not limited to, metabolic rate, menstrual function, bone health, immunity, protein synthesis, cardiovascular health caused by relative energy deficiency. The cause of this syndrome is energy deficiency relative to the balance between dietary energy intake and energy expenditure required for health and activities of daily living, growth and sporting activities. Psychological consequences can either precede RED-S or be the result of RED-S. The clinical phenomenon is not a 'triad' of the three entities of energy availability, menstrual function and bone health, but rather a syndrome that affects many aspects of physiological function, health and athletic performance. This Consensus Statement also recommends practical clinical models for the management of affected athletes. The 'Sport Risk Assessment and Return to Play Model' categorises the syndrome into three groups and translates these classifications into clinical recommendations.

  20. Silvical characteristics of red maple (Acer rubrum)

    Science.gov (United States)

    Russell J. Hutnik; Harry W. Yawney

    1961-01-01

    Red maple (Acer rubrum L.) is also known as Carolina red maple, scarlet maple, soft maple, swamp maple, water maple, and white maple. Taxonomists recognize several varieties of red maple. The most common is Drummond red maple (Acer rubrum var. drummondii (Hook, & Arn.) Sarg.).

  1. Corpo, mito e imaginário nos postais das praias cariocas

    Directory of Open Access Journals (Sweden)

    Euler David de Siqueira

    Full Text Available "Cidade Maravilhosa", "capital cultural", o Rio de Janeiro é ícone do Brasil em uma série de discursos, entre eles o turístico. As bancas de jornal da cidade exibem cartões-postais com fotos que exploram a imagem do corpo feminino na orla carioca e a mostram como imagem da cidade. A partir da análise de uma amostra intencional e não-probabilística de exemplares dessa mídia, o objetivo deste trabalho é o de estudar a relação entre o corpo e o espaço urbano na construção do imaginário sobre a cidade do Rio de Janeiro. Entre alguns dos resultados encontrados, observa-se a construção de um imaginário que reforça antigos clichês em que a cidade do Rio de Janeiro e seus personagens são apresentados como tendo uma natureza sensual, quente e festiva.

  2. Elaboração de questionário de frequência alimentar semiquantitativo para adolescentes da região metropolitana do Rio de Janeiro, Brasil Development of a semiquantitative food frequency questionnaire for adolescents from the Rio de Janeiro metropolitan area, Brazil

    Directory of Open Access Journals (Sweden)

    Marina Campos Araujo

    2010-04-01

    Full Text Available OBJETIVO: Descrever a elaboração de um questionário de frequência alimentar para adolescentes do Rio de Janeiro, Brasil. MÉTODOS: Para seleção dos itens alimentares incluídos no questionário de frequência alimentar, utilizaram-se dados de três dias de registro alimentar obtidos em uma amostra de 430 estudantes, na faixa etária de 12 a 19 anos, da rede de ensino estadual de Niterói, Rio de Janeiro. Foram incluídos os itens alimentares mais citados nos registros e que contribuíram com 95% do consumo de energia e nutrientes dos registros alimentares. As porções de referência foram as mais frequentemente referidas nos registros do estudo de base. As opções de frequência foram definidas de forma diferenciada para os diversos itens do questionário. RESULTADOS: Nos registros foram listados 306 alimentos, dos quais 249 itens foram incluídos no questionário, isoladamente ou agrupados, compondo uma lista de 90 itens. Os 14 itens alimentares mais consumidos por adolescentes do Rio de Janeiro, nesse estudo e em estudo anterior, foram associados a oito opções de frequência de consumo; 18 itens alimentares foram acoplados a sete opções de frequência e para 58 itens foram definidas cinco opções de frequência. CONCLUSÃO: O estudo permitiu a elaboração do questionário de frequência alimentar para adolescentes da Região Metropolitana do Rio de Janeiro, o qual será submetido às análises de reprodutibilidade e validade. Este questionário representa um instrumento valioso para pesquisas epidemiológicas que investiguem o consumo alimentar de adolescentes.OBJECTIVE: The objective of this study was to describe the development of a food frequency questionnaire for adolescents from the Rio de Janeiro metropolitan area, Brazil. METHODS: The selection of food items included in the questionnaire was done by recording the foods consumed during 3 days by 430 students aged 12 to 19 years from the public schools of Niterói (RJ Brasil

  3. Relatório integrador da actividade profissional

    OpenAIRE

    Oliveira, Maria João Belo

    2015-01-01

    Relatório integrador da atividade profissional para a obtenção do Grau de Mestre em Tecnologia Alimentar, na Escola Superior Agrária, do Instituto Politécnico de Santarém A informação apresentada neste relatório pretende demonstrar como algumas das competências adquiridas ao longo da formação académica foram aplicadas e desenvolvidas em contexto profissional. São apresentadas as empresas onde a autora colaborou, descrevendo-se as atividades desenvolvidas. A autora obteve em 199...

  4. Adoção da Web 2.0 em bibliotecas de universidades públicas espanholas: perspectivas de interação do bibliotecário com as redes sociais - relato de pesquisa

    OpenAIRE

    Vieira, David Vernon; Baptista, Sofia Galvão; Cuevas Cerveró, Aurora

    2013-01-01

    O surgimento da Web Social proporcionou um espaço virtual de participação dos usuários de bibliotecas. Assim, casos de adoção de redes sociais têm sido observados nas bibliotecas universitárias espanholas desde 2005, quando se publicaram os primeiros artigos científicos para acompanhar este movimento. Considerando o âmbito das bibliotecas de universidades públicas na Espanha, foi realizada uma pesquisa exploratória para conhecer a situação real do modelo de presença dessas bibliotecas nas red...

  5. New species and records of the genus Aegla Leach, 1820 (Crustacea, Anomura, Aeglidae from the West-Central region of Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Sandro Santos

    Full Text Available Aeglidae are anomuran freshwater "crabs" found only in southern South America. In Brazil, the greatest species diversity occurs in hydrographic basins of the state of Rio Grande do Sul. Two new species, Aegla georginae and Aegla ludwigi, are described from the Ibicuí and Ijuí Rivers, respectively (Uruguay River Basin. The new taxa can be distinguished from other Aegla species based on both morphological and molecular characters. The two new species have a very restricted distribution and are categorized as endangered (A. georginae and critically endangered (A. ludwigi using IUCN Red List criteria. We also summarize and present new records of the Aegla species occurring in the Uruguay River Basin.

  6. O Barão do Rio Branco opina sobre o Marechal Deodoro

    Directory of Open Access Journals (Sweden)

    E. Bradford Burns

    1967-06-01

    Full Text Available O Barão do Rio Branco era partidário dedicado da monarquia. Herdou essa convicção de seu ilustre pai, um dos maiores estadistas do Império; e êle mesmo serviu com muito zêlo e dedicação ao Imperador quando na Europa.

  7. Características de repositório educacional aberto para usuários de língua brasileira de sinais

    Directory of Open Access Journals (Sweden)

    Romario Antunes da Silva

    Full Text Available O objetivo desse artigo é identificar as características que um repositório educacional aberto deve apresentar para atender as necessidade de informação dos alunos surdos e ouvintes do curso Letras Libras na modalidade a distância da Universidade Federal de Santa Catarina. Os objetivos específicos foram: a descrever o perfil dos alunos surdos e ouvintes; b examinar o uso das tecnologias da informação por esses alunos; e c identificar os documentos que um repositório deve apresentar para atender as necessidades de informação desses alunos. A pesquisa é exploratória, descritiva e qualitativo-quantitativa, e a análise foi realizada com estatística descritiva e análise de conteúdo. Conclui-se que os alunos utilizam o e-mail, as listas de discussão, o Messenger, ferramentas para compartilhamento de vídeos e os sites para surdos. Os alunos consideram muito importantes os processadores de texto, Messenger, Movie Maker, Media Player e planilhas para cálculo. Os alunos surdos consideram como documentos mais relevantes as videoaulas, dicionários e apostilas, e os alunos ouvintes, as videoaulas, os livros e as apostilas. O tipo de conteúdo requisitado são notícias sobre surdos, língua brasileira de sinais, tradução, tecnologia, linguística, aprendizagem do português, interpretação médico-jurídica e cultura surda. Os suportes requisitados para acesso à informação são os dicionários, vídeos, livros digitais e artigos. Os alunos preferem acessar as informações no repositório por meio de língua de sinais, legendas e em português.

  8. Território e Rede da União do Vegetal

    OpenAIRE

    Morales Arteaga, Pamela Elizabeth

    2016-01-01

    Esta pesquisa trata do território e das redes geográficas da religião ayahusaqueira União do Vegetal, em Brasília. Busca-se interpretar os objetivos da pesquisa que foram; a construção do território da União do Vegetal, diferençando elementos relevantes do território; debatendo a hierarquização do grupo na sua atuação territorial e relacionando as percepções dos adeptos com suas práticas territoriais em rede. As hipóteses que nortearam o trabalho foram; A construção do território sagrado da U...

  9. The passage from Rio.

    Science.gov (United States)

    Strong, M F

    1992-01-01

    The Secretary-General of the UN Conference on Environment and Development notes that after the Earth Summit in Rio de Janeiro discussions about the environment and development will differ from those prior to the Summit. These discussions must now incorporate problems of developing countries, poverty, inequalities, flow of resources to developing countries, and terms of trade. The Rio Declaration on Environment and Development consists of important tenets, but it must evolve into an Earth Charter to be endorsed on the 50th anniversary of the UN in 1965. The Summit's Plan of Action, Agenda 21, must also continue to evolve and, despite its shortcomings, is the most extensive and, if implemented, most effective international action ever approved by the international community. Financing the Agenda 21 initiatives remains to be decided. New possible sources of funding must be based n the polluter pays principle and may include new taxes, user charges, emission permits, and citizen funding. Even though the most serious problem in the 1990s is stabilization of atmospheric gases, the Rio agreement does not include targets or timetables. Governments must take united action immediately to reduce carbon dioxide emissions by at least 60%. 1 nation has not yet approved the convention on biological diversity. Governments also need to move forward on conventions on decertification and deforestation. They need to incorporate the global objectives of Agenda 21 into their own national policies and practices. This must also be done at the global, regional, organizational, local, and individual levels. The global community must also begin technology capacity building. The participatory process should also include nongovernmental organizations. Population growth must also slow dramatically to achieve sustainable development. The various participatory levels must consider elimination of poverty.

  10. Antimicrobial activities of pomelo (Citrus maxima) seed and pulp ethanolic extract

    Science.gov (United States)

    Sahlan, Muhamad; Damayanti, Vina; Tristantini, Dewi; Hermansyah, Heri; Wijanarko, Anondho; Olivia, Yuko

    2018-02-01

    Grapefruit (Citrus paradisi) seed extract is generally used as naturopathic medications, supplements, antiseptic and disinfecting agents and also as preservatives in food and cosmetics products. In vitro studies have demonstrated that grapefruit seed extract has anti bacterial properties against a range of gram-positive and gram-negative organisms. Indonesian grapefruit, known as pomelo (C. maxima), has similar characteristics, contents and is under the same genus (Citrus) as grapefruit; however it has not been completely utilized as a preservative. In this work we analyze the antimicrobial activities of ethanolic extract of Indonesian pomelo (C. maxima) seeds and pulp compared to the grapefruit (C. paradisi) seeds and pulp ethanolic extract. Ethanolic extracts of pomelo and grapefruit seeds and pulp are investigated for activities against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Candida albicans. The level of antimicrobial effects is established using agar diffusion method. Both of the ethanolic do not show any antimicrobial activities against C. albicans. The ethanolic extract of pomelo seeds and pulp used in this research give positive results with growth inhibition effect on B. subtilis, S. aureus and E. coli. The zones of inhibition ranges from 22 - 30 mm in diameter, which is higher to grapefruit seeds and pulp ethanolic extract (17 - 25 mm). Ethanolic extract of pomelo seeds and pulp has an antimicrobial effect, which makes it a natural preparation for use as an alternative preservative for food and cosmetic.

  11. O aniversário do Pasquim: 22 anos em 5

    Directory of Open Access Journals (Sweden)

    Márcia Neme Buzalaf

    2009-04-01

    Full Text Available Resenha: Pasquim 40 anos: Edição Comemorativa. Rio de Janeiro: Desiderata, 2009, 40 p. e Antologia do Pasquim - volume III:1973-1974, de Jaguar e Sérgio Augusto (Org.. Rio de Janeiro: Desiderata, 2009, 376 p.

  12. Bases epidemiológicas do Fator Acidentário Previdenciário Epidemiological foundations of the Accident Insurance Factor

    Directory of Open Access Journals (Sweden)

    Vilma Sousa Santana

    2005-12-01

    Full Text Available ANTECEDENTES: O Conselho Nacional de Previdência Social, por meio da Resolução No. 1.236 de 28/4/2004, aprovou uma nova metodologia para definição do valor das alíquotas de contribuição devidas por empresas para o financiamento de benefícios previdenciários relacionados aos riscos do trabalho. Esta metodologia baseia-se em um indicador denominado de Fator Acidentário Previdenciário, FAP, construído a partir do risco epidemiológico, estimado para cada ramo de atividade econômica. Como parte da sua estratégia de validação, o Ministério da Previdência Social decidiu pela avaliação da sua consistência epidemiológica. OBJETIVOS: Nesse estudo analisaram-se os propósitos, as fontes de informação, a natureza das medidas epidemiológicas empregadas e a metodologia da construção desse indicador, identificando-se as suas vantagens e limitações, aplicabilidade e impactos potenciais futuros. MÉTODOS: Análise documental da Resolução No. 1236 e do documento anexo. RESULTADOS: O FAP avança ao se pautar por critérios científicos transparentes que poderão permitir a redução das alíquotas quando houver efetiva melhoria das condições de trabalho, e conseqüentemente, da morbimortalidade entre trabalhadores. Supera as dificuldades relacionadas à definição e registro do nexo causal das doenças do trabalho ao considerá-las em sua totalidade, não se restringido às ocupacionais. Como prevê a redução de alíquotas com a melhoria das condições de saúde dos trabalhadores poderá contribuir para uma mais efetiva atuação dos empregadores na prevenção. CONCLUSÕES: É necessário o acompanhamento contínuo e sistemático da aplicação do FAP, com ampla participação da sociedade, revisando-o e ajustando-o aos diferentes cenários econômicos, sociais e de saúde do País, atentando-se para o seu impacto sobre a arrecadação e contas da Previdência Social.BACKGROUND: The Brazilian National Social Insurance

  13. A combination of grapefruit seed extract and concentrated cranberry juice as a potential antimicrobial preservative for the improvement of microbiological stability of hypromellose gel.

    Science.gov (United States)

    Bernatoniene, Jurga; Keraitė, Rasa; Masteiková, Ruta; Pavilonis, Alvydas; Savickas, Arūnas

    2013-10-01

    Aqueous hypromellose gels are not microbiologically stable - they show signs of microorganism growth during storage. To extend the shelf-life of the gels, antimicrobial preservatives are needed. Some substances of plant origin are known for their antimicrobial properties, and thus they may be used as an alternative to synthetic preservatives. Therefore, the aim of this study was to evaluate the microbiological stability of aqueous hypromellose gel and the effectiveness of natural substances - grapefruit seed extract (GSE), concentrated cranberry juice, and a combination thereof - on the antimicrobial protection of the gel. The evaluation of the antimicrobial activity of GSE and cranberry juice showed that their antimicrobial effects differed. Both cranberry juice and GSE inhibited the growth of the standard gram-positive and gram-negative bacteria, but the effect of GSE was significantly stronger. Candida albicans was sensitive only to GSE. For this reason, in order to affect all the microorganisms studied, either a combination of 0.7% GSE and 10% cranberry juice, or 5% GSE alone may be used. The combination of GSE and cranberry juice was effective only in acidic medium (pH being 2.5-5), while the antimicrobial effect of GSE was not dependent on the pH value.

  14. Motivações de candidatos e voluntários na Cidade Viva

    Directory of Open Access Journals (Sweden)

    Jéssika Kadidja de Oliveira Medeiros

    2017-07-01

    Full Text Available O trabalho voluntário é a força das organizações da sociedade civil. Existem diferenças entre o trabalho voluntário e o formal, como a remuneração e o tempo destinado ao desempenho das atividades. Ao contrário de trabalhadores formais, voluntários não recebem pagamento para o desempenho de funções. Logo, teorias motivacionais desenvolvidas numa perspectiva de trabalho formal não devem ser aplicadas a este grupo. Esse estudo identificou motivações apresentadas pelos candidatos a voluntários e atuais voluntários da Fundação Cidade Viva em João Pessoa. Quanto aos resultados, verifica-se predominância do perfil altruísta em ambas as fases utilizadas do modelo. Ainda, o perfil egoísta, foi o menos apresentado pelos respondentes da pesquisa. Outros resultados, relativos ao desligamento da atividade voluntária na Fundação, foram bastante inconclusivos.

  15. Red Sirius

    Energy Technology Data Exchange (ETDEWEB)

    Martynov, D Ya

    1976-01-01

    A hypothesis is proposed explaining the assumption that Sirius changed its colour from red in the second century to pale blue in the tenth century A.D. The hypothesis is based on the possibility of transformation of a Sirius satellite (Sirius B) from a red giant in the past to a white dwarf in the present. Such a transformation would have been accompanied by an explosion of Sirius B, which is clearly visible from the Earth. The fact that the increase in Sirius brightness by 4-5 units is not reflected in historical chronicles is attributed to the degradation of sciences in Europe in 4-10 centuries.

  16. Estado nutricional e tempo de tela de escolares da Rede Pública de Ensino Fundamental de Niterói, Rio de Janeiro, Brasil Estado nutricional y tiempo de pantalla de escolares de la red pública de enseñanza fundamental de Niterói, Río de Janeiro, Brasil Nutritional status and screen time among public school students in Niterói, Rio de Janeiro State, Brazil

    Directory of Open Access Journals (Sweden)

    Mauricio Teixeira Leite de Vasconcellos

    2013-04-01

    Full Text Available O presente estudo avaliou o estado nutricional relacionado ao tempo de tela (computado como o somatório de assistir à televisão, usar computador e jogar videogame e à prática de atividade física, por meio de questionário semiestruturado, em uma amostra probabilística (n = 328, sendo 108 meninos de escolares (10 a 18 anos de idade do sexto ao nono ano da Rede Pública de Ensino Fundamental de Niterói, Rio de Janeiro, Brasil. Déficit de estatura não foi um problema nos escolares, mas 25,7% tinham excesso de peso, sendo 18% com sobrepeso e 7,7% com obesidade. A média de tempo semanal de televisão foi de 24,2h, sendo maior entre as meninas. O tempo de tela não foi diferente entre sexo, mas os meninos, independentemente da idade, passavam mais tempo jogando videogame do que as meninas. Os meninos dedicavam o dobro de tempo realizando atividade física em relação às meninas de todas as idades e o triplo na faixa de 14 anos de idade ou mais. O tempo de tela associou-se significativamente com o excesso de peso. Conclui-se que os escolares da Rede Pública de Ensino Fundamental de Niterói apresentam elevada prevalência de excesso de peso associado a estilo de vida inadequado.El presente estudio evalúo el estado nutricional, relacionado con el tiempo dedicado a ver la televisión (computado como la suma de ver la televisión, usar el ordenador y jugar videojuegos y la práctica de actividad física, mediante un cuestionario semiestructurado, en una muestra probabilística (n = 328, siendo 108 niños de escolares (10 a 18 años de edad del sexto al noveno año de la red pública de enseñanza fundamental de Niterói, Río de Janeiro, Brasil. El déficit de estatura no fue un problema en los escolares, pero un 25,7% tenían un exceso de peso, estando un 18% con sobrepeso y un 7,7% con obesidad. La media de tiempo semanal de televisión fue de 24,2h, siendo mayor entre las niñas. El tiempo dedicado a ver la televisión no fue diferente

  17. RED Alert – Early warning or detection of global re-emerging infectious disease (RED)

    Energy Technology Data Exchange (ETDEWEB)

    Deshpande, Alina [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-13

    This is the PDF of a presentation for a webinar given by Los Alamos National Laboratory (LANL) on the early warning or detection of global re-emerging infectious disease (RED). First, there is an overview of LANL biosurveillance tools. Then, information is given about RED Alert. Next, a demonstration is given of a component prototype. RED Alert is an analysis tool that can provide early warning or detection of the re-emergence of an infectious disease at the global level, but through a local lens.

  18. Suscetibilidade de biótipos de arroz-vermelho e de cultivares de arroz irrigado ao herbicida imazethapyr Susceptibility of red rice biotypes and commercial rice cultivars to imazethapyr

    Directory of Open Access Journals (Sweden)

    S.H.B. Dornelles

    2010-01-01

    Full Text Available Para avaliar a suscetibilidade de biótipos de arroz-vermelho(Oryza sativa e cultivares comerciais de arroz ao herbicida imazethapyr, realizou-se um ensaio em casa de vegetação com cinco biótipos de arroz-vermelho (acessos Santa Maria 5, Pelotas 3, Rio Pardo 1, Manoel Viana 2 e Catuçaba 1, dois cultivares comerciais de arroz: Clearfield® (IRGA 422 CL e Puitá INTA CL e um cultivar convencional (IRGA 417. Utilizou-se a metodologia de curvas de dose-resposta proposta por Seefeldt et al. (1995. A metodologia de curvas de resposta foi gerada a partir dos parâmetros do modelo logístico e dos valores de I50. Os biótipos de arroz-vermelho e os cultivares foram submetidos a seis doses do herbicida imazethapyr (0; 33,12; 66,25; 132,5; 265,0; e 530,0 g i.a. ha-1. As plantas de arroz foram contadas e coletadas no 20º dia após a aplicação dos tratamentos. A análise do percentual de dano foi realizada através de avaliação visual da fitointoxicação (%, massa verde e massa seca das plantas. Analisando as curvas e os resultados da análise da variância, pode-se inferir que os cultivares Clearfield Irga 422 CL e Puitá INTA CL foram significativamente iguais ao biótipo de arroz-vermelho Catuçaba 1, resistindo a doses de imazethapyr superiores à recomendada em campo para o sistema Clearfield®. Os biótipos Manoel Viana 2, Santa Maria 5 e Pelotas 3 agruparam-se com o cultivar convencional IRGA 417, sendo suscetíveis à dose comercial do herbicida. O biótipo Rio Pardo 1 também é resistente ao herbicida imazethapyr, porém menos resistente que o biótipo Catuçaba 1.To evaluate the susceptibility of biotypes of red rice (Oryza sativa and commercial rice cultivars to the herbicide imazethapyr, a greenhouse assay was conducted with five red rice biotypes (accesses Santa Maria 5, Pelotas 3, Rio Pardo 1, 2 and Manoel Viana Catuçaba 1, two commercial rice cultivars: Clearfield ® (Irga CL 422 and CL Puit INTA, and a conventional cultivar (Irga

  19. Prevalência, distribuição geográfica e sazonal de protozoários e mixozoários parasitos de jaú (Zungaro jahu no Pantanal Matogrossense

    Directory of Open Access Journals (Sweden)

    Edson A. Adriano

    2012-12-01

    Full Text Available Estudo realizado no Pantanal Matogrossense, avaliou a prevalência, a distribuição geográfica e sazonal de protozoários e mixozoários parasitos de jaú (Zungaro jahu. Os peixes foram capturados no Sul do Pantanal, na região dos rios Aquidauana, Miranda e Paraguai, em 2001, 2002 e 2003, na região Central (Parque Nacional do Pantanal - PARNA Pantanal em 2003, 2004, 2005 e 2008, e na região Norte (rios Cuiabá e Manso, no município de Nobres em 2003, 2004 e 2005. Foi identificado Trichodina sp. parasitando pele e brânquias de jaú nas três regiões estudadas. Ocorrência de Epistylis sp. na pele e Cryptobia sp. nas brânquias foram restritas às coletas da região Central, enquanto Ichthyophthirius multifiliis foi identificado parasitando a pele nas três regiões estudadas. Também foi observada a ocorrência de mixozoários, Myxobolus cordeiroi parasitando vários órgãos e Henneguya sp. parasitando brânquias de jaú das três regiões estudadas.

  20. Do documentário histórico ao imaginário antropológico do regime militar brasileiro: uma leitura simbólica sobre o golpe de 1964

    Directory of Open Access Journals (Sweden)

    Eduardo Portanova Barros

    2017-09-01

    Full Text Available Este artigo oferece uma leitura simbólica sobre o imaginário que movimenta seis filmes documentários relativos ao regime militar brasileiro. Elegemos os Estudos do Imaginário como heurística apropriada à revelação de imagens simbólicas, simbolismos e narrativas míticas estimuladas pelas representações fílmicas tanto do governo de João Goulart quanto do golpe civil-militar que o tirou da Presidência da República. A partir de documentação audiovisual, acessamos os elementos constitutivos do imaginário que move as obras. Assim, esperamos proporcionar uma complementação ao entendimento sobre esse período obscuro da sociedade brasileira, bem como oferecer uma abordagem alternativa à pesquisa em Comunicação sobre documentários históricos.

  1. BRIQUETAGEM DE FINOS DE CALCÁRIO

    Directory of Open Access Journals (Sweden)

    Mariana Rezende Barros

    2015-12-01

    Full Text Available Aplicação da tecnologia na agricultura dentro do sistema de produção é realidade principalmente com a abertura de mercados através da globalização. Em diversas áreas da indústria moderna, o calcário é utilizado como corretor da acidez do solo. A calagem é uma prática barata, porém ainda é negligenciada quanto ao seu uso, na adoção da técnica, à definição das doses e às formas de aplicação. A briquetagem consiste na aglomeração de partículas finas através de pressão, auxiliada ou não por aglomerantes, permitindo obtenção de produtos compactados, com forma, tamanho e parâmetros mecânicos adequados. A redução de volume do material, além dos benefícios tecnológicos, permite que materiais finos possam ser transportados e armazenados de forma mais econômica. A recente preocupação ambiental, resultando em leis mais rígidas, além da necessidade de aproveitar economicamente os resíduos e as partículas finas geradas no beneficiamento de minérios fez com que a briquetagem voltasse a ser uma importante alternativa para aglomerar valor econômico. O objetivo deste trabalho foi aglomerar finos de calcário através da briquetagem (92% abaixo de 500# ou 25 µm gerados no processamento do mesmo, variando as dosagens de água (utilizada como agente aglomerante de 0; 5; 7,5; 10; 12,5 e 15%. O calcário, originário de Lagamar (MG, foi classificado quimicamente como dolomítico tipo D. Os briquetes foram submetidos a testes de queda a 30, 60, 90, 120 e 150 cm de altura. Os melhores resultados encontrados para ensaios de queda foram obtidos com 7,5% de umidade, com médias de 21 quedas para 30 cm e 10 quedas para 60 cm de altura. Tais resultados apresentaram-se favoráveis quando comparados à literatura, a qual cita que para briquetes sem cura, considera-se 3 quedas a 0,3 m como valor razoável.

  2. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha.

    Directory of Open Access Journals (Sweden)

    Jonathan Goldwasser

    2010-08-01

    Full Text Available Disruption of lipid and carbohydrate homeostasis is an important factor in the development of prevalent metabolic diseases such as diabetes, obesity, and atherosclerosis. Therefore, small molecules that could reduce insulin dependence and regulate dyslipidemia could have a dramatic effect on public health. The grapefruit flavonoid naringenin has been shown to normalize lipids in diabetes and hypercholesterolemia, as well as inhibit the production of HCV. Here, we demonstrate that naringenin regulates the activity of nuclear receptors PPARalpha, PPARgamma, and LXRalpha. We show it activates the ligand-binding domain of both PPARalpha and PPARgamma, while inhibiting LXRalpha in GAL4-fusion reporters. Using TR-FRET, we show that naringenin is a partial agonist of LXRalpha, inhibiting its association with Trap220 co-activator in the presence of TO901317. In addition, naringenin induces the expression of PPARalpha co-activator, PGC1alpha. The flavonoid activates PPAR response element (PPRE while suppressing LXRalpha response element (LXRE in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR. This effect results in the induction of a fasted-like state in primary rat hepatocytes in which fatty acid oxidation increases, while cholesterol and bile acid production decreases. Our findings explain the myriad effects of naringenin and support its continued clinical development. Of note, this is the first description of a non-toxic, naturally occurring LXRalpha inhibitor.

  3. Ensino religioso e assistência religiosa no Rio Grande do Sul: quadros exploratórios = Religious education and religious assistance in Rio Grande do Sul: exploratory frameworks

    Directory of Open Access Journals (Sweden)

    Giumbelli, Emerson

    2011-01-01

    Full Text Available Partindo de uma perspectiva que se interessa pelas configurações geradas pela relação entre sociedade e religião, o texto aborda dois temas: ensino religioso em escolas públicas e assistência religiosa em instituições destinadas à internação de adolescentes que cumprem medida socioeducativa. A maior parte dos dados refere-se ao Rio Grande do Sul, procurando-se apresentar um quadro exploratório para ambos os temas. Mais especificamente, os resultados incidem sobre as formas que caracterizam o modo de relação entre determinadas instituições públicas e a religião e o modo pelo qual se definem configurações de diversidade religiosa

  4. A new species of Microglanis (Siluriformes: Pseudopimelodidae from upper rio Paraná basin, Brazil

    Directory of Open Access Journals (Sweden)

    Oscar Akio Shibatta

    Full Text Available Microglanis garavelloi, new species, collected in tributaries of rio Paranapanema and rio Tietê, is the first species of the genus described from upper rio Paraná basin. The new species can be distinguished from other species of Microglanis on morphometric characters, color pattern, caudal-fin shape, pectoral-spine morphology and lateral line development. Characters used specifically to distinguish M. garavelloi from M. cottoides (laguna dos Patos and rio Uruguay basins and M. parahybae (rio Paraíba do Sul basin include morphometrics, color pattern and pectoral-spine serration.

  5. Stable isotope-labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults.

    Science.gov (United States)

    de Vries, Ronald; Smit, Johan W; Hellemans, Peter; Jiao, James; Murphy, Joseph; Skee, Donna; Snoeys, Jan; Sukbuntherng, Juthamas; Vliegen, Maarten; de Zwart, Loeckie; Mannaert, Erik; de Jong, Jan

    2016-02-01

    Ibrutinib, an inhibitor of Bruton's tyrosine kinase, is used in the treatment of mantle cell lymphoma or chronic lymphocytic leukaemia. Ibrutinib undergoes extensive rapid oxidative metabolism mediated by cytochrome P450 3A both at the level of first pass and clearance, which might result in low oral bioavailability. The present study was designed to investigate the absolute bioavailability (F) of ibrutinib in the fasting and fed state and assess the effect of grapefruit juice (GFJ) on the systemic exposure of ibrutinib in order to determine the fraction escaping the gut (Fg ) and the fraction escaping hepatic extraction (Fh ) in the fed state. All participants received treatment A [560 mg oral ibrutinib, under fasting conditions], B (560 mg PO ibrutinib, fed, administered after drinking glucose drink) and C (140 mg oral ibrutinib, fed, with intake of GFJ before dosing). A single intravenous (i.v.) dose of 100 μg (13) C6 -ibrutinib was administered 2 h after each oral dose. The estimated 'F' for treatments A, B and C was 3.9%, 8.4% and 15.9%, respectively. Fg and Fh in the fed state were 47.0% and 15.9%, respectively. Adverse events were mild to moderate in severity (Grade 1-2) and resolved without sequelae by the end of the study. The absolute oral bioavailability of ibrutinib was low, ranging from 3.9% in the fasting state to 8.4% when administered 30 min before a standard breakfast without GFJ and 15.9% with GFJ. Ibrutinib was well tolerated following a single oral and i.v. dose, under both fasted and fed conditions and regardless of GFJ intake status. © 2015 The British Pharmacological Society.

  6. Stable isotope‐labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults

    Science.gov (United States)

    Smit, Johan W.; Hellemans, Peter; Jiao, James; Murphy, Joseph; Skee, Donna; Snoeys, Jan; Sukbuntherng, Juthamas; Vliegen, Maarten; de Zwart, Loeckie; Mannaert, Erik; de Jong, Jan

    2016-01-01

    Aims Ibrutinib, an inhibitor of Bruton's tyrosine kinase, is used in the treatment of mantle cell lymphoma or chronic lymphocytic leukaemia. Ibrutinib undergoes extensive rapid oxidative metabolism mediated by cytochrome P450 3A both at the level of first pass and clearance, which might result in low oral bioavailability. The present study was designed to investigate the absolute bioavailability (F) of ibrutinib in the fasting and fed state and assess the effect of grapefruit juice (GFJ) on the systemic exposure of ibrutinib in order to determine the fraction escaping the gut (Fg) and the fraction escaping hepatic extraction (Fh) in the fed state. Methods All participants received treatment A [560 mg oral ibrutinib, under fasting conditions], B (560 mg PO ibrutinib, fed, administered after drinking glucose drink) and C (140 mg oral ibrutinib, fed, with intake of GFJ before dosing). A single intravenous (i.v.) dose of 100 μg 13C6‐ibrutinib was administered 2 h after each oral dose. Results The estimated ‘F’ for treatments A, B and C was 3.9%, 8.4% and 15.9%, respectively. Fg and Fh in the fed state were 47.0% and 15.9%, respectively. Adverse events were mild to moderate in severity (Grade 1–2) and resolved without sequelae by the end of the study. Conclusion The absolute oral bioavailability of ibrutinib was low, ranging from 3.9% in the fasting state to 8.4% when administered 30 min before a standard breakfast without GFJ and 15.9% with GFJ. Ibrutinib was well tolerated following a single oral and i.v. dose, under both fasted and fed conditions and regardless of GFJ intake status. PMID:26382728

  7. Metagenomic studies of the Red Sea.

    Science.gov (United States)

    Behzad, Hayedeh; Ibarra, Martin Augusto; Mineta, Katsuhiko; Gojobori, Takashi

    2016-02-01

    Metagenomics has significantly advanced the field of marine microbial ecology, revealing the vast diversity of previously unknown microbial life forms in different marine niches. The tremendous amount of data generated has enabled identification of a large number of microbial genes (metagenomes), their community interactions, adaptation mechanisms, and their potential applications in pharmaceutical and biotechnology-based industries. Comparative metagenomics reveals that microbial diversity is a function of the local environment, meaning that unique or unusual environments typically harbor novel microbial species with unique genes and metabolic pathways. The Red Sea has an abundance of unique characteristics; however, its microbiota is one of the least studied among marine environments. The Red Sea harbors approximately 25 hot anoxic brine pools, plus a vibrant coral reef ecosystem. Physiochemical studies describe the Red Sea as an oligotrophic environment that contains one of the warmest and saltiest waters in the world with year-round high UV radiations. These characteristics are believed to have shaped the evolution of microbial communities in the Red Sea. Over-representation of genes involved in DNA repair, high-intensity light responses, and osmoregulation were found in the Red Sea metagenomic databases suggesting acquisition of specific environmental adaptation by the Red Sea microbiota. The Red Sea brine pools harbor a diverse range of halophilic and thermophilic bacterial and archaeal communities, which are potential sources of enzymes for pharmaceutical and biotechnology-based application. Understanding the mechanisms of these adaptations and their function within the larger ecosystem could also prove useful in light of predicted global warming scenarios where global ocean temperatures are expected to rise by 1-3°C in the next few decades. In this review, we provide an overview of the published metagenomic studies that were conducted in the Red Sea, and

  8. Antibacterial Compounds from Red Seaweeds (Rhodophyta

    Directory of Open Access Journals (Sweden)

    Noer Kasanah

    2015-07-01

    Full Text Available Seaweeds produce great variety of metabolites benefit for human. Red seaweeds (Rhodophyta are well known as producer of phycocolloids such agar, agarose, carragenan and great variety of secondary metabolites. This review discusses the red algal secondary metabolites with antibacterial activity. The chemical constituents of red algae are steroid, terpenoid, acetogenin and dominated by halogenated compounds mainly brominated compounds. Novel compounds with intriguing skeleton are also reported such as bromophycolides and neurymenolides. In summary, red seaweeds are potential sources for antibacterial agents and can serve as lead in synthesis of new natural medicines.

  9. "Congo" red: out of Africa?

    Science.gov (United States)

    Steensma, D P

    2001-02-01

    Congo red is the essential histologic stain for demonstrating the presence of amyloidosis in fixed tissues. To the best of my knowledge, nothing has been written about why the stain is named "Congo." To understand the etymology and history of the Congo red histologic stain. Primary sources were consulted extensively, including 19th-century corporate documents, newspapers, legal briefs, patents, memoirs, and scientific papers. Sources were obtained from multiple university libraries and German corporate archives. To Europeans in 1885, the word Congo evoked exotic images of far-off central Africa known as The Dark Continent. The African Congo was also a political flashpoint during the Age of Colonialism. "Congo" red was introduced in Berlin in 1885 as the first of the economically lucrative direct textile dyes. A patent on Congo red was filed by the AGFA Corporation of Berlin 3 weeks after the conclusion of the well-publicized Berlin West Africa Conference. During these important diplomatic talks, German Chancellor Otto von Bismarck presided over a discussion of free trade issues in the Congo River basin. A challenge to AGFA's Congo red patent led to a precedent-setting decision in intellectual property law. The Congo red stain was named "Congo" for marketing purposes by a German textile dyestuff company in 1885, reflecting geopolitical current events of that time.

  10. White dwarf-red dwarf binaries in the Galaxy

    NARCIS (Netherlands)

    Besselaar, E.J.M. van den

    2007-01-01

    This PhD thesis shows several studies on white dwarf - red dwarf binaries. White dwarfs are the end products of most stars and red dwarfs are normal hydrogen burning low-mass stars. White dwarf - red dwarf binaries are both blue (white dwarf) and red (red dwarf). Together with the fact that they are

  11. Upper Rio Grande water operations model: A tool for enhanced system management

    Science.gov (United States)

    Gail Stockton; D. Michael Roark

    1999-01-01

    The Upper Rio Grande Water Operations Model (URGWOM) under development through a multi-agency effort has demonstrated capability to represent the physical river/reservoir system, to track and account for Rio Grande flows and imported San Juan flows, and to forecast flows at various points in the system. Testing of the Rio Chama portion of the water operations model was...

  12. Inteligência emocional: estudo exploratório

    OpenAIRE

    Seabra, Diana Catarina Lopes

    2013-01-01

    A presente dissertação tem como objetivo esclarecer e refletir sobre a inteligência emocional e explorar se existe uma influência entre a atividade que o grupo exerce, o tempo de pertença e o tempo de vida do mesmo, ao nível da inteligência emocional grupal e das suas dimensões. Para tal, foi desenvolvido um estudo exploratório. A recolha dos dados realizou-se através do Questionário de Inteligência Emocional Grupal traduzido e adaptado por Correia (2010) do Group Emotional Intelligence Quest...

  13. Comentários e Notícias

    OpenAIRE

    BAD, Cadernos

    2004-01-01

    • Disposições que regulam o exame de admissão ao curso de Bibliotecário-Arquivistas• Júri do exame de aptidão ao Curso de Bibliotecário-Arquivista• Actividade da Comissão Técnica Portuguesa de Normalização (CT-7).• Estágios no CDCU. (1) Regulamento• O complexo problema do livro português. O Instituto Nacional do Livro e da Bibliografia Portuguesa• Criação da «Casa-Biblioteca Tomaz da Fonseca»• Novas bibliotecas municipais em Lisboa• Arquivo Distrital de Aveiro• Fichas de Documentação - um ser...

  14. Decadal Stability of Red Sea Mangroves

    KAUST Repository

    Almahasheer, Hanan; Aljowair, Abdulaziz; Duarte, Carlos M.; Irigoien, Xabier

    2015-01-01

    Across the Earth, mangroves play an important role in coastal protection, both as nurseries and carbon sinks. However, due to various human and environmental impacts, the coverage of mangroves is declining on a global scale. The Red Sea is in the northern-most area of the distribution range of mangroves. Little is known about the surface covered by mangroves at this northern limit or about the changes experienced by Red Sea mangroves. We sought to study changes in the coverage of Red Sea mangroves by using multi-temporal Landsat data (1972, 2000 and 2013). Interestingly, our results show that there has been no decline in mangrove stands in the Red Sea but rather a slight increase. The area covered by mangroves is about 69 Km2 along the African shore and 51 Km2 along the Arabian Peninsula shore. From 1972 to 2013, the area covered by mangroves increased by about 0.29% y-1. We conclude that the trend exhibited by Red Sea mangroves departs from the general global decline of mangroves. Along the Red Sea, mangroves expanded by 12% over the 41 years from 1972 to 2013. Losses to Red Sea mangroves, mostly due to coastal development, have been compensated by afforestation projects.

  15. Decadal Stability of Red Sea Mangroves

    KAUST Repository

    Almahasheer, Hanan

    2015-12-15

    Across the Earth, mangroves play an important role in coastal protection, both as nurseries and carbon sinks. However, due to various human and environmental impacts, the coverage of mangroves is declining on a global scale. The Red Sea is in the northern-most area of the distribution range of mangroves. Little is known about the surface covered by mangroves at this northern limit or about the changes experienced by Red Sea mangroves. We sought to study changes in the coverage of Red Sea mangroves by using multi-temporal Landsat data (1972, 2000 and 2013). Interestingly, our results show that there has been no decline in mangrove stands in the Red Sea but rather a slight increase. The area covered by mangroves is about 69 Km2 along the African shore and 51 Km2 along the Arabian Peninsula shore. From 1972 to 2013, the area covered by mangroves increased by about 0.29% y-1. We conclude that the trend exhibited by Red Sea mangroves departs from the general global decline of mangroves. Along the Red Sea, mangroves expanded by 12% over the 41 years from 1972 to 2013. Losses to Red Sea mangroves, mostly due to coastal development, have been compensated by afforestation projects.

  16. Sensory acceptance tests of red beet (Beta vulgaris ssp. vulgaris L.), cv. Early Wonder, minimally processed and irradiated

    International Nuclear Information System (INIS)

    Hernandes, Nilber Kenup; Vital, Helio de Carvalho

    2007-01-01

    Red beet (Early Wonder) was cultivated in an experimental area of the Department of Fitotecnia at the Institute of Agronomy at the Rural Federal University of Rio de Janeiro. After harvest, the roots were minimally processed; packed; exposed to different doses of gamma radiation (0; 0.5; 1.0 and 1.5 kGy) and stored for 20 days at 8.0 deg C. Sensory evaluations were performed 1; 9; 13 and 20 days after irradiation by 12 testers who rated the overall appearance and aroma on a hedonic scale. The results indicated that the irradiated samples remained within the limit of acceptance for 20 days. In addition, the aroma was found to be a more sensitive indicator of the effect of different doses of radiation to the acceptance of the product. (author)

  17. Diagnóstico da floricultura no Rio Grande do Sul Diagnosis of floriculture in Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Atelene Normann Kämpf

    1999-09-01

    Full Text Available O objetivo deste trabalho foi avaliar o segmento da produção de flores e plantas ornamentais no Rio Grande do Sul, Brasil, por meio de um levantamento a campo. O estudo faz parte de um projeto global, apoiado pelo Instituto Brasileiro de Floricultura (IBRAFLOR e pelo Ministério da Agricultura e do Abastecimento (MAARA, através do Departamento Nacional de Cooperativismo (DENACOOP. Com base nos formulários preenchidos nas propriedades, foi elaborado um cadastro dos floricultores, com seus endereços e produções. A floricultura gaúcha conta com 257 produtores, que cultivam o total de 304ha em 65 municípios; 30% dessa área é ocupada com flores de corte, 33% com mudas para jardim, 29% com outros produtos da floricultura e 8% com plantas envasadas. O sistema de cultivo predominante é a céu aberto (89%, com baixos investimentos tecnológicos.A survey was conducted to quantify flower and ornamental plant production in the State of Rio Grande do Sul State, Brazil. The Brazilian Floriculture Institute (IBRAFLOR and the Agriculture Ministry (MAARA - DENACOOP granted this research. Based on an inventory formulary a catalog including the nurseries, addresses and main crops was elaborated. There are 257 growers in this State with an area of 304ha distributed among 65 counties; 30% of this area are cultivated with cut flowers, 33% with annuals and perennials for garden, 29% with other floriculture products and 8% with potted plants. The main system of cultivation is not protected with low technological investments.

  18. From red giants to planetary nebulae

    International Nuclear Information System (INIS)

    Kwok, S.

    1982-01-01

    The transition from red giants to planetary nebulae is studied by comparing the spectral characteristics of red giant envelopes and planetary nebulae. Observational and theoretical evidence both suggest that remnants of red giant envelopes may still be present in planetary nebula systems and should have significant effects on their formation. The dynamical effects of the interaction of stellar winds from central stars of planetary nebulae with the remnant red giant envelopes are evaluated and the mechanism found to be capable of producing the observed masses and momenta of planetary nebulae. The observed mass-radii relation of planetary nebulae may also be best explained by the interacting winds model. The possibility that red giant mass loss, and therefore the production of planetary nebulae, is different between Population I and II systems is also discussed

  19. 76 FR 6517 - San Luis & Rio Grande Railroad-Petition for a Declaratory Order

    Science.gov (United States)

    2011-02-04

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35380] San Luis & Rio... petition filed by San Luis & Rio Grande Railroad (SLRG), the Board instituted a declaratory order... proposed operation of a truck-to-rail transload facility in Antonito, Colorado. See San Luis & Rio Grande R...

  20. red - an R package to facilitate species red list assessments according to the IUCN criteria

    Directory of Open Access Journals (Sweden)

    Pedro Cardoso

    2017-10-01

    Full Text Available The International Union for the Conservation of Nature Red List is the most useful database of species that are at risk of extinction worldwide, as it relies on a number of objective criteria and is now widely adopted. The R package red – IUCN Redlisting Tools - performs a number of spatial analyses based on either observed occurrences or estimated ranges. Functions include calculating Extent of Occurrence (EOO, Area of Occupancy (AOO, mapping species ranges, species distribution modelling using climate and land cover and calculating the Red List Index for groups of species. The package allows the calculation of confidence limits for all measures. Spatial data of species occurrences, environmental or land cover variables can be either given by the user or automatically extracted from several online databases. It outputs geographical range, elevation and country values, maps in several formats and vectorial data for visualization in Google Earth. Several examples are shown demonstrating the usefulness of the different methods. The red package constitutes an open platform for further development of new tools to facilitate red list assessments.

  1. red - an R package to facilitate species red list assessments according to the IUCN criteria.

    Science.gov (United States)

    Cardoso, Pedro

    2017-01-01

    The International Union for the Conservation of Nature Red List is the most useful database of species that are at risk of extinction worldwide, as it relies on a number of objective criteria and is now widely adopted. The R package red - IUCN Redlisting Tools - performs a number of spatial analyses based on either observed occurrences or estimated ranges. Functions include calculating Extent of Occurrence (EOO), Area of Occupancy (AOO), mapping species ranges, species distribution modelling using climate and land cover and calculating the Red List Index for groups of species. The package allows the calculation of confidence limits for all measures. Spatial data of species occurrences, environmental or land cover variables can be either given by the user or automatically extracted from several online databases. It outputs geographical range, elevation and country values, maps in several formats and vectorial data for visualization in Google Earth. Several examples are shown demonstrating the usefulness of the different methods. The red package constitutes an open platform for further development of new tools to facilitate red list assessments.

  2. Habitability of planets around red dwarf stars.

    Science.gov (United States)

    Heath, M J; Doyle, L R; Joshi, M M; Haberle, R M

    1999-08-01

    Recent models indicate that relatively moderate climates could exist on Earth-sized planets in synchronous rotation around red dwarf stars. Investigation of the global water cycle, availability of photosynthetically active radiation in red dwarf sunlight, and the biological implications of stellar flares, which can be frequent for red dwarfs, suggests that higher plant habitability of red dwarf planets may be possible.

  3. Electromagnetically Inferred Structure of the Caja del Rio Plateau, New Mexico

    Science.gov (United States)

    Layton, M. E.; Speed, C.; Shukla, M.; Vila, A.; Chon, E.; Kitamikado, C.; Feucht, D. W.; Bedrosian, P.; Pellerin, L.

    2016-12-01

    Magnetotelluric (MT) and transient electromagnetic (TEM) data were acquired by students from the Summer of Applied Geophysical Experience (SAGE) to construct structural models in and around the Caja del Rio Plateau, New Mexico. The Caja del Rio is located on the La Bajada-Jemez constriction that separates the Española and Santa Domingo basins in the Rio Grande Rift. The Rio Grande Rift, the result of tectonic extensional forces, extends approximately north-south across northern New Mexico. MT data collected in 2016 were merged with that from previous years to make up an 11 km north line and a 16 km south line extending from the west side of the Caja Del Rio to the east off the plateau in the Old Buckman Road area. The resistivity distributions revealed in one-dimensional (1-D) and two-dimensional (2-D) inverse models show some robust features. Models of the north are interpreted as a top resistive layer (convention) point in the northwest direction towards the conductive Valles Caldera. The MT models are consistent with geologic interpretations of the stratigraphic units. In addition, models disclose an additional conductive layer below the basement that we interpret as the mid-crustal conductor. Transient electromagnetic (TEM) data were collected in seven locations atop the Caja del Rio plateau in an attempt to identify the basal contact of the Cerros del Rio volcanic field, which, in turn, allow for the thickness of these basaltic and andesitic deposits to be mapped across the plateau. One-dimensional inverse models produced from the TEM data were aligned and interpreted geologically. A resistive ( 1000 ohm-m) unit, interpreted to represent the Cerros del Rio volcanics, thickens from 70m to 175m from southeast to northwest. The volcanics are overlain by a thin conductor, interpreted as weathered material. The resistive body is underlain by a thicker conductor, interpreted as sedimentary rocks of the Tertiary-aged Santa Fe Group.

  4. Crescimento pessoal, mediação e sacrifício: itinerários sociais de estudantes beneficiários do Prouni

    Directory of Open Access Journals (Sweden)

    Andrea Bayerl Mongim

    2015-12-01

    Full Text Available Resumo: Este artigo analisa itinerários sociais de estudantes oriundos de famílias consideradas de classes populares e beneficiários do ProUni. Discute o processo de constituição de significados e de incorporação prática de princípios que concorreram para construção e objetivação do projeto de aquisição do título universitário. Tal projeto é construído de forma não naturalizada, efetivando-se pela interação com agentes mediadores, posicionados em quadros institucionais que ultrapassam os limites das redes de relações da família nuclear. A conclusão do curso superior representa a possibilidade de exercer profissão melhor remunerada e valorizada e de incluir-se em grupo de maior prestígio e status.

  5. A satisfação do usuário em hospital universitário User satisfaction at a university hospital

    Directory of Open Access Journals (Sweden)

    Antonio C. Lemme

    1991-02-01

    Full Text Available São apresentados resultados de uma pesquisa exploratória da satisfação/insatisfação de 158 pacientes que recorreram a um Hospital Universitário (HUPE para consulta inicial. As entrevistas foram feitas por alunos do primeiro ano, como parte de projeto de inserção precoce do mesmo com a prática médica, acompanhando pacientes como observadores. Foi utilizado questionário que cobriu os vários aspectos do problema: variáveis sócio-demográficas, arte do cuidado, resolutividade da consulta médica, sugestões de melhoria dos serviços. Tanto alunos/observadores como os usuários conseguiram perceber com precisão os problemas do processo do atendimento (recepção, matrícula, consulta, enfermagem, serviço social, farmácia, exames complementares mas houve divergência de opinião entre vários aspectos da satisfação/insatisfação entre alunos e usuários, provavelmente devido às origens sociais diferentes e expectativas diversas.The results of a research project into the level of satisfaction/dissatisfaction of 158 first-time patients attending by an University hospital, Brazil, are presented. The interviews were carried out by first year medical students as part of a comprehensive project concerned with the restructuring of the Medical Curriculum. Its prime objective was to expose the students to patients/consumers as early as possible in their studies. After an introductory training program, the students asked the patients arriving at the hospital out-patient clinic for permission to observe them throughout the attendance given. A questionnaire was used which covered the various aspects of the consumers relationship with a medical institution (socio-economic variables, "art of care", outcome of the medical encounter and suggestions for improvement. Both patients and students were able to perceive the different problems that patients confront in the course of their dealings with a medical institution (reception, registration

  6. Don't Take This with That!

    Medline Plus

    Full Text Available ... active ingredient, grapefruit can reduce the effectiveness of a drug or worse, create potentially dangerous drug levels in the body. Grapefruit can interfere with transporters ...

  7. Metazoários parasitos de seis espécies de peixes do Reservatório de Lajes, Estado do Rio de Janeiro, Brasil Metazoan parasites of six fishes species from Lajes Reservoir in the State of Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Aline R. Paraguassú

    2007-09-01

    Full Text Available Entre abril de 2002 e julho de 2003, foram necropsiados 231 espécimes de peixes: 39 Astyanax bimaculatus (Linnaeus, 1758, 79 A. fasciatus (Cuvier, 1819, 23 Hypostomus affinis (Steindachner, 1877, 26 Hoplias malabaricus (Bloch, 1794, 30 Loricariichthys castaneus (Castelnau, 1855 e 34 Trachelyopterus striatulus (Steindachner, 1876 provenientes do Reservatório de Lajes (22º42' - 22º50'S, 43º53' 44º05'O, Estado do Rio de Janeiro, Brasil, para estudo das suas comunidades parasitárias. A maioria dos espécimes de H. affinis (95,6% e H. malabaricus (84,6% estavam parasitados por pelo menos uma espécie de metazoário. Em A. bimaculatus, A. fasciatus, L. castaneus e T. striatulus 41%, 39,2%, 56,7% e 14,7% dos espécimes estavam parasitados, respectivamente. Foram coletadas oito diferentes espécies de metazoários parasitos: 2 em A. bimaculatus, 3 em A. fasciatus, 3 em H. affinis, 4 em H. malabaricus, 4 em L. castaneus e 1 em T. striatulus. As comunidades de metazoários parasitos das seis espécies de peixes estudadas apresentaram típico padrão de distribuição agregada. Foram observados dois casos de correlação negativa entre a abundância e a prevalência parasitárias e o comprimento total dos hospedeiros. A comunidade parasitária de L. castaneus apresentou os maiores valores de intensidade média, índice de dispersão e diversidade. As comunidades parasitárias dos peixes estudados apresentaram escassez de correlação entre a abundância, riqueza parasitária e diversidade com o comprimento total dos hospedeiros. Os baixos valores de riqueza e diversidade das comuni-dades parasitárias podem ser atribuídos as características oligotróficas do Reservatório de Lajes.From April 2002 to July 2003, 231 freshwater fishes from Lajes Reservoir in the State of Rio de Janeiro, Brazil (22º42' - 22º50'S, 43º53' - 44º05'W were necropsied to study their community metazoan parasites: 39 Astyanax bimaculatus (Linnaeus, 1758, 79 A. fasciatus

  8. SEDIMENTAÇÃO FLUVIAL QUATERNÁRIA NO VALE DO ALTO CURSO DO RIO MACAÉ, ESTADO DO RIO DE JANEIRO, BRASIL.

    Directory of Open Access Journals (Sweden)

    Mônica dos Santos Marçal

    2015-09-01

    Full Text Available O trabalho foi desenvolvido no vale do alto curso do rio Macaé, norte do estado do Rio de Janeiro, e tem como objetivo apresentar as análises geomorfológicas e estratigráficas, além das idades obtidas com o método da luminescência (LOE, realizadas em feições sedimentares de terraços fluviais. Foram selecionadas duas áreas de sedimentação denominadas AS-1, localizada mais a montante do vale, e AS-2 mais a jusante. As feições ocorrem em quatro níveis, sendo três níveis de terraço fluvial, denominados Nível Superior (T1, Nível Intermediário (T2 e Nível Inferior (T3, e um Nível de Planície de Inundação atual (PI. Estão distribuídos de forma descontínua, predominantemente na margem esquerda do rio Macaé, sendo que a planície de inundação (PI ocorre em níveis diferentes em cada margem do vale. Os resultados obtidos das datações por LOE para os sedimentos dos três níveis de terraços (T1, T2 e T3 apresentam boa correspondência às evidências geomorfológicas e estratigráficas utilizadas na definição dos níveis deposicionais aluviais.

  9. Red alder: a state of knowledge.

    Science.gov (United States)

    Robert L. Deal; Constance A. Harrington

    2006-01-01

    In March 23-25, 2005, an international symposium on red alder was held at the University of Washington Center for Urban Horticulture in Seattle, WA. The symposium was entitled "Red alder: A State of Knowledge" and brought together regional experts to critically examine the economic, ecological and social values of red alder. The primary goal of the symposium...

  10. Infecções do trato urinário

    OpenAIRE

    Barros, Susana; Cambão, Marta; Vieira, Sandra; Estevinho, Leticia M.

    2005-01-01

    O sistema urinário é uma das quatro vias de excreção existentes no corpo humano. A sua exposição a factores exteriores e/ou interiores torna-o sensível a diversas infecções, pelo que, actualmente, em termos de quadro clínico. as patologias relacionadas com as infecções do tracto urinário (ITU), nomeadamente, a uretrite, cistite, síndroma uretral agudo e pielonefrite, são bastantes comuns.

  11. Infra Red 3D Computer Mouse

    DEFF Research Database (Denmark)

    Harbo, Anders La-Cour; Stoustrup, Jakob

    2000-01-01

    The infra red 3D mouse is a three dimensional input device to a computer. It works by determining the position of an arbitrary object (like a hand) by emitting infra red signals from a number of locations and measuring the reflected intensities. To maximize stability, robustness, and use of bandw......The infra red 3D mouse is a three dimensional input device to a computer. It works by determining the position of an arbitrary object (like a hand) by emitting infra red signals from a number of locations and measuring the reflected intensities. To maximize stability, robustness, and use...

  12. Brazilian Social Psychology in the international context: a commentary A Psicologia Social brasileira no cenário internacional: um comentário

    Directory of Open Access Journals (Sweden)

    Joaquim Pires Valentim

    2013-03-01

    Full Text Available The present paper is a commentary on the talks given by Torres and Álvaro and by Krüger regarding Brazilian Social Psychology in the international context. Starting with a brief contrast with the situation in Portugal, this commentary next approaches, in a synthetic way, questions that cut across social psychology in the international setting, namely, those related with the recurrent dichotomy individual/collective, the great advances in social neuroscience, the study of minorities, the scarcity of psychosocial research about colonialism, and lastly, contemporary issues of science and educational policy.Faz-se aqui um comentário às intervenções de Torres e Álvaro e de Krüger sobre a Psicologia Social brasileira no cenário internacional. Começando por estabelecer um breve contraste com a situação em Portugal, de seguida este comentário aborda, de forma sintética, questões transversais à psicologia social no cenário internacional, designadamente as que se relacionam com a recorrente dicotomia individual/coletivo, os enormes avanços na neurociência social, o estudo das minorias, a escassez de estudos psicossociais sobre o colonialismo e, por último, questões contemporâneas de política científica e de ensino.

  13. A new species of Hemigrammus Gill, 1858 (Characiformes: Characidae from the rio Madeira and rio Paraguai basins, with a redescription of H. lunatus

    Directory of Open Access Journals (Sweden)

    Rafaela P. Ota

    Full Text Available A new Hemigrammusis described from the rio Paraguai and rio Madeira basins, Mato Grosso and Rondônia States, Brazil. The new species is characterized by possessing a wide dark horizontal stripe across the eye, a vertically elongated humeral blotch, and 4-5 gill-rakers on upper branch and 9-10 on lower. The new species can be easily diagnosed from H. lunatus, the sympatric and morphologically most similar congener, by the shape of humeral blotch and the number of gill rakers. Data of the type material of both Hemigrammus lunatus and H. maxillaris, as well as extensive examination of specimens, allowed us to conclude that H. maxillarisis a junior subjective synonym of H. lunatus. A redescription of H. lunatus, as well as a formal restriction of its type locality, is provided. A putative monophyletic group within Hemigrammus, composed by H. barrigonae, Hemigrammus lunatus, H. machadoi new species, and H. ulreyi, named Hemigrammus lunatus group, is proposed based on overall body morphology and color pattern. Additionally, a discussion on the biogeographical relationships between the rio Paraguai and rio Guaporé basins is provided.

  14. Avaliação do controle externo da qualidade nos laboratórios clínicos do Rio de Janeiro de 2006 a 2008

    OpenAIRE

    Chaves,Josefa Sieira Caamaño; Marin,Victor Augustus

    2010-01-01

    INTRODUÇÃO: O Controle Externo da Qualidade (CEQ) é uma ferramenta importante para a garantia da qualidade das análises laboratoriais, auxiliando o laboratório a avaliar a eficiência da fase analítica de seus processos. Um resultado errôneo de uma análise prejudica a conclusão do diagnóstico de uma enfermidade e a indicação correta do tratamento a ser tomado. As inspeções sanitárias em laboratórios clínicos (LCs) no estado do Rio de Janeiro são feitas com base no roteiro de inspeção sanitária...

  15. Controlo dos acessórios de elevação

    OpenAIRE

    Costa, Ana Luisa Nogueira da

    2016-01-01

    Relatório de Estágio apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Segurança e Higiene no Trabalho O relatório é o trabalho final da 8ª Edição do Mestrado de Segurança e Higiene no Trabalho, da Escola Superior de Ciências Empresariais em parceria com a Escola Superior de Tecnologia de Setúbal, do Instituto Politécnico de Setúbal. O estágio desenrolou-se nas instalações da empresa LUSOSIDER, sob a orientação da Técnica Superior em SHST Eng....

  16. Mechanisms of immune red cell destruction, and red cell compatibility testing

    International Nuclear Information System (INIS)

    Garratty, G.

    1983-01-01

    The immune destruction of red cells can occur as a complement-mediated intravascular process, or extravascularly, where the red cells are destroyed by macrophages following interaction with cell-bound IgG1, IgG3, and/or C3b. Many of the factors that affect this in vivo destruction are not taken into account during in vitro pretransfusion compatibility testing. At present, even by use of more elaborate tests, it is difficult to accurately predict the fate of a transfused unit of blood. By using some simple information, such as antibody specificity and thermal range, it is sometimes possible to predict the outcome of transfusing a unit of blood that is incompatible in vitro. At other times it may be necessary to utilize 51 Cr-labeled red cells to determine the risk of transfusing such units. Because of the paucity of reported clinical correlations, macrophage/monocyte monolayer assays are of little practical value at present

  17. Plants, arthropods, and birds of the Rio Grande [chapter 7

    Science.gov (United States)

    Deborah M. Finch; Gale L. Wolters; Wang Yong; Mary Jean Mund

    1995-01-01

    Human populations have increased dramatically along the Rio Grande since European settlement. Human use of water for irrigation and consumption, and human use of land for agriculture, urban centers, livestock grazing, and recreation have changed Rio Grande ecosystems by altering flood cycles, channel geomorphology, upslope processes, and water quality and quantity....

  18. Breves comentários sobre as teorias marxistas de imigração

    Directory of Open Access Journals (Sweden)

    Raul Felix Barbosa

    2017-10-01

    Full Text Available Sabe-se que o capitalismo possui sua parcela de responsabilidade nos movimentos migratórios, voluntários ou forçados, do período pós-revolução industrial. Apesar de Karl Marx não ter abordado diretamente a questão migratório, a teoria marxista e neomarxista se ocupa de explicar os processos migratórios. Esse artigo realiza um levantamento das teorias migratórias de origem marxista apresentando-as, bem como as críticas recebidas.

  19. Crianças em situação de violência de um ambulatório do Rio de Janeiro: conhecendo seu perfil Niños en situación de violencia de un ambulatorio en Rio de Janeiro: conociendo su perfil Children under violence situation followed-up in the outpatient setting at Rio de Janeiro: knowing their profile

    OpenAIRE

    Lucia Martins de Magalhães Pierantoni; Ivone Evangelista Cabral

    2009-01-01

    Buscou-se caracterizar as crianças envolvidas em situação de violência e seus familiares, e analisar o papel social do agressor/protetor no círculo da violência. Estudo quantitativo descritivo foi desenvolvido no Ambulatório da Família de um Hospital do Rio de Janeiro, entre 2006 e 2007. Dados do prontuário de 44 crianças demonstraram intensa relação entre pobreza, baixa escolaridade e gênero na matriz social da violência. Houve maior registro de meninos (64%) expostos a violência do que meni...

  20. Saúde reprodutiva e mulheres indígenas do Alto Rio Negro

    Directory of Open Access Journals (Sweden)

    Marta Azevedo

    Full Text Available O presente artigo descreve e analisa as concepções próprias das mulheres indígenas do Alto Rio Negro sobre saúde reprodutiva, relacionando-as a indicadores de fecundidade. As informações qualitativas apontam para um conhecimento detalhado e complexo que as mulheres indígenas dessa região possuem sobre seu corpo e os cuidados com sua saúde. Os níveis e padrões etários da fecundidade estão relacionados com a etnia das mulheres, portanto, aos sistemas tradicionais de cuidados com a saúde desses povos. A pesquisa foi desenvolvida entre 1997 e 2003, na região de Iauaretê, Terra Indígena Alto Rio Negro (AM, e teve como primeira fonte de dados o Censo Indígena Autônomo do Rio Negro - CIARN-, levado a efeito pela Federação das Organizações Indígenas do Rio Negro - FOIRN - em 1992.

  1. Plantas medicinais em quintais urbanos de Rio Branco, Acre Medicinal plants in urban backyards in Rio Branco, Acre

    Directory of Open Access Journals (Sweden)

    A. Siviero

    2012-01-01

    Full Text Available Este trabalho teve como objetivo realizar levantamento das espécies vegetais de uso medicinal cultivadas em quintais urbanos da cidade de Rio Branco. Foram realizadas entrevistas presenciais com aplicação de questionário especifico registrando as espécies vegetais de uso medicinal e dados sócio-econômicos dos moradores em 132 quintais urbanos de Rio Branco entre 2009 e 2010. Os bairros selecionados para o estudo foram: Aeroporto Velho, Placas, e Novo Horizonte, todos situados na periferia do município. Foram detectadas 83 espécies vegetais de uso medicinal pertencente a 50 famílias botânicas com destaque para Lamiaceae (12,0% e Asteraceae (6,0%, sendo 66,2% exóticas, e 28,9% e 16,8%, associadas ao uso alimentar e ornamental, respectivamente. A decocção das folhas visando à obtenção do chá foi o principal modo de preparo das plantas. A análise de regressão logística entre a riqueza de espécies e diversos fatores socioeconômicos dos entrevistados mostrou que a probabilidade de ocorrência de espécies é três vezes maior em quintais manejados por moradores com idade superior a 50 anos de idade. A análise de correlação não paramétrica de fatores quantitativos mostrou que a variável tempo de moradia está mais correlacionada com a riqueza de plantas medicinais do que a variável idade. O cultivo das plantas medicinais em quintais urbanos de Rio Branco auxilia no combate a doenças e promove a conservação ex situ da agrobiodiversidade agroflorestal, bem estar aos moradores pela melhoria da paisagem, ambiência microclimática e espaço de lazer.This study aimed to survey the medicinal plant species grown in urban backyards in the city of Rio Branco. Personal interviews were conducted by applying a specific questionnaire recording the plant species of medicinal use and the socioeconomic data of residents in 132 urban backyards in Rio Branco between 2009 and 2010. The districts selected for the study were "Aeroporto

  2. Combined effects of blue light and supplemental far-red light and effects of increasing red light with constant far-red light on growth of kidney bean [Phaseolus vulgaris] under mixtures of narrow-band light sources

    International Nuclear Information System (INIS)

    Hanyu, H.; Shoji, K.

    2000-01-01

    Increasing blue light and decreasing R: FR with supplementary far-red light affect morphogenesis, dry matter production and dry matter partitioning to leaves, stems and roots. In this study, the combined effects of the two spectral treatments were examined in kidney bean (Phaseolus vulgaris L.) grown under the mixture of four different narrow-band light sources. In addition, because the leaf and stem growth are accelerated by increasing red light (600-700 nm) in proportion to far-red light (700-800 nm) while keeping R : FR constant, this study was conducted to determine whether red light or far-red light causes the acceleration of growth. Increasing blue light (400-500 nm) and decreasing R : FR only interacted on stem extension. The results illustrated with figures suggest that blue light amplifies or attenuates the acceleration of stem extension caused by decreasing R : FR. On the other hand, increasing red light with constant far-red light had no influence on leaf expansion or stem extension while R : FR increased. Because the acceleration of leaf and stem growth is caused by increasing either far-red light or both red and far-red light in our environmental conditions, the stimulative effects on leaves and stems seem to require increases in far-red light rather than red light

  3. Diseño de una red WAN

    OpenAIRE

    Labella Sanz, Gabriel

    2010-01-01

    Disseny d'una xarxa WAN, formada per una xarxa d'Accés HFC, una xarxa de Commutació ATM i una xarxa de Transport SDH. Diseño de una red WAN, formada por una red de Acceso HFC, una red de Conmutación ATM y una red de Transporte SDH. WAN network design consisting of a HFC access network, an ATM switching network and a SDH transport network.

  4. Spectral relationships for atmospheric correction. I. Validation of red and near infra-red marine reflectance relationships.

    Science.gov (United States)

    Goyens, C; Jamet, C; Ruddick, K G

    2013-09-09

    The present study provides an extensive overview of red and near infra-red (NIR) spectral relationships found in the literature and used to constrain red or NIR-modeling schemes in current atmospheric correction (AC) algorithms with the aim to improve water-leaving reflectance retrievals, ρw(λ), in turbid waters. However, most of these spectral relationships have been developed with restricted datasets and, subsequently, may not be globally valid, explaining the need of an accurate validation exercise. Spectral relationships are validated here with turbid in situ data for ρw(λ). Functions estimating ρw(λ) in the red were only valid for moderately turbid waters (ρw(λNIR) turbidity ranges presented in the in situ dataset. In the NIR region of the spectrum, the constant NIR reflectance ratio suggested by Ruddick et al. (2006) (Limnol. Oceanogr. 51, 1167-1179), was valid for moderately to very turbid waters (ρw(λNIR) turbid waters (ρw(λNIR) > 10(-2)). The results of this study suggest to use the red bounding equations and the polynomial NIR function to constrain red or NIR-modeling schemes in AC processes with the aim to improve ρw(λ) retrievals where current AC algorithms fail.

  5. Don't Take This with That!

    Medline Plus

    Full Text Available ... especially when combining grapefruit with medicines. While it can be part of a balanced and nutritious diet, grapefruit can have serious consequences when taken with certain medications. ...

  6. Effect of Red Pepper ( Powder or Red Pepper Pigment on the Performance and Egg Yolk Color of Laying Hens

    Directory of Open Access Journals (Sweden)

    Huaqiang Li

    2012-11-01

    Full Text Available Two experiments were conducted to study the effects of red pepper (Capsicum frutescens powder or red pepper pigment on the performance and egg yolk color of laying hens. In Exp. 1, 210, thirty-wk old, Hy-line Brown laying hens were fed one of seven diets containing 0.3, 0.6, 1.2, 2.0, 4.8 or 9.6 ppm red pepper pigment or 0.3 ppm carophyll red. Each diet was fed to three replicate batteries of hens with each battery consisting of a row of five cages of hens with two hens per cage (n = 3. In Exp. 2, 180, thirty-wk old, Hyline Brown laying hens, housed similarly to those in Exp. 1, were fed an unsupplemented basal diet as well as treatments in which the basal diet was supplemented with 0.8% red pepper powder processed in a laboratory blender to an average particle size of 300 μm, 0.8% red pepper powder processed as a super fine powder with a vibrational mill (44 μm and finally 0.8% red pepper powder processed as a super fine powder with a vibrational mill but mixed with 5% Na2CO3 either before or after grinding. A diet supplemented with 0.3 ppm carophyll red pigment was also included (n = 3. In both experiments, hens were fed the red pepper powder or pigment for 14 days. After feeding of the powder or pigment was terminated, all hens were fed the basal diet for eight more days to determine if the dietary treatments had any residual effects. In Exp. 1, there were no differences in egg-laying performance, feed consumption or feed conversion ratio due to inclusion of red pepper pigment in the diet. Average egg weight was higher (p0.05. However, compared with the control group, supplementation with all of the red pepper powder treatments increased egg weight (p<0.05. All the red pepper powder treatments also increased (p<0.05 the yolk color score compared with the control. The results of the present study suggest that both red pepper powder and pigment are effective feed additives for improving egg yolk color for laying hens.

  7. Monitorização da ponte sobre o rio Kwanza na Cabala

    OpenAIRE

    Oliveira Santos, L.; Santos, J.; Xu, Min

    2011-01-01

    A presente comunicação visa divulgar os trabalhos de monitorização da nova ponte sobre o rio Kwanza, na localidade da Cabala, levados a cabo pelo Laboratório Nacional de Engenharia Civil e pelo Laboratório de Engenharia de Angola. Para além da apresentação do plano geral de observação e da descrição dos ensaios estáticos e dinâmicos realizados no final da construção, é dada uma ênfase particular a aspectos inovadores, como a monitorização do nível do rio e da evolução morfol...

  8. Experience reverses the red effect among Chinese stockbrokers.

    Science.gov (United States)

    Zhang, Tengxiao; Han, Buxin

    2014-01-01

    Recent research has shown that the color red influences psychological functioning. Red is hypothesized to be linked to aggression and danger in evolution, and these links are enhanced by culture-specific uses of red. Thus, color meanings are thought to be grounded in biologically based proclivities and learned associations. However, to date, there has been no direct evidence for the influence of experience on the red effect. This study focused on whether experience could change the psychological effects of the color red. In the context of the Chinese stock market, contrary to the meaning generally associated with red as negative and green as positive, red represents a rise in stock price and green stands for a decrease. An experiment using a 2×2 between subjects factorial design demonstrated that red (compared with green) impaired Chinese college students' performance on an IQ test (in accordance with the red effect), but the opposite effect was found among stockbrokers. These results provide direct evidence of learned color meanings, in support of the general model of color effect.

  9. [Separation and identification of red pigments in natural red yolk of duck's eggs by HPLC-MS-MS].

    Science.gov (United States)

    Liu, Liangzhong; Zhang, Min; Peng, Guanghua; Wang, Haibin; Zhang, Shenghua

    2004-05-01

    The natural red yolk of duck's eggs is produced by the laying duck in the lake areas in southward of China. In the laying duck breeding areas such as Honghu, Jianli, Xiantao, Tianmen and Hanchuan citys in Hubei Province, the culturists are used to feeding fresh pondweeds to the laying ducks. The yolk of duck's eggs is natural red with the chrominance reaching up to and/or above RCF (Roche Yolk Color Fan) 15. The red pigment components of natural red yolk of duck's eggs were separated and identified by thin layer chromatography (TLC), high performance liquid chromatography-mass spectrometry-mass spectrometry (HPLC-MS-MS) and high resolution electron impact-mass spectrometry (EI-MS). Four isomers of red pigments were separated by HPLC on a RP-C18 column with methanol-water (99.5:0.5, v/v) as mobile phase. The lambda(max) of the four components were 482, 488, 496, 501 nm, respectively, and all of them were single peak on chromatogram. They had the same molecular mass (Mr = 562), and had the same fragment peaks of MS2 with rhodoxanthin. The molecular formula of red pigments was determined as C40H50O2 by high resolution EI-MS. The results indicate that the red pigment is rhodoxanthin, and they are all cis-isomers of rhodoxanthin.

  10. Calcification–carbonation method for red mud processing

    Energy Technology Data Exchange (ETDEWEB)

    Li, Ruibing [School of Metallurgy, Northeastern University, Shenyang 110819 (China); Laboratory for Simulation and Modelling of Particulate Systems, Department of Chemical Engineering, Monash University, Clayton, Victoria, 3800 (Australia); Zhang, Tingan, E-mail: zhangta@smm.neu.edu.cn [School of Metallurgy, Northeastern University, Shenyang 110819 (China); Liu, Yan; Lv, Guozhi; Xie, Liqun [School of Metallurgy, Northeastern University, Shenyang 110819 (China)

    2016-10-05

    Highlights: • A new approach named calcification–carbonation method for red mud processing is proposed. • The method can prevent emission of red mud from alumina production and is good for the environment. • Thermodynamics characteristics were investigated. • The method was verified experimentally using a jet-flow reactor. - Abstract: Red mud, the Bayer process residue, is generated from alumina industry and causes environmental problem. In this paper, a novel calcification–carbonation method that utilized a large amount of the Bayer process residue is proposed. Using this method, the red mud was calcified with lime to transform the silicon phase into hydrogarnet, and the alkali in red mud was recovered. Then, the resulting hydrogarnet was decomposed by CO{sub 2} carbonation, affording calcium silicate, calcium carbonate, and aluminum hydroxide. Alumina was recovered using an alkaline solution at a low temperature. The effects of the new process were analyzed by thermodynamics analysis and experiments. The extraction efficiency of the alumina and soda obtained from the red mud reached 49.4% and 96.8%, respectively. The new red mud with <0.3% alkali can be used in cement production. Using a combination of this method and cement production, the Bayer process red mud can be completely utilized.

  11. Uptake of carnitine by red blood cells

    International Nuclear Information System (INIS)

    Campa, M.; Borum, P.

    1986-01-01

    A significant amount of blood carnitine (70% of cord blood and 40% of blood from healthy adults) is partitioned into the red blood cell compartment of whole blood. Data indicate that the plasma compartment and the red blood cell compartment of whole blood represent different metabolic pools of carnitine. There are no data to indicate that red blood cells synthesize carnitine, but our understanding of the uptake of carnitine by red blood cells is negligible. Red blood cells were obtained from healthy adults, washed twice with normal saline, and used for uptake experiments. When the cells were incubated at 37 0 C in the presence of 14 C-carnitine, radioactivity was found both in the soluble cytosolic and membrane fractions of the cells following lysis. The uptake was dependent upon the time of incubation, temperature of incubation, and carnitine concentration in the incubation medium. Washed red blood cell membranes incubated with 14 C-carnitine showed specific binding of radioactivity. These data are consistent with the hypothesis that red blood cells have an uptake mechanism for L-carnitine

  12. ESD and the Rio Conventions

    Science.gov (United States)

    Sarabhai, Kartikeya V.; Ravindranath, Shailaja; Schwarz, Rixa; Vyas, Purvi

    2012-01-01

    Chapter 36 of Agenda 21, a key document of the 1992 Earth Summit, emphasised reorienting education towards sustainable development. While two of the Rio conventions, the Convention on Biological Diversity (CBD) and the United Nations Framework Convention on Climate Change (UNFCCC), developed communication, education and public awareness (CEPA)…

  13. Leishmaniose tegumentar americana: casuística hospitalar no Rio de Janeiro American tegumentary Leishmaniasis: hospitalized cases in Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Nurimar C. Fernandes

    2004-08-01

    Full Text Available FUNDAMENTOS: A leishmaniose tegumentar americana distribui-se amplamente no Brasil, e o Estado do Rio de Janeiro (capital e interior constitui área endêmica onde o vetor é encontrado dentro e ao redor das habitações. OBJETIVOS: Análise prospectiva de 48 casos de leishmaniose tegumentar americana atendidos no Hospital Universitário Clementino Fraga Filho/UFRJ, no período de 1990 a 2002. MÉTODOS: Todos os pacientes foram submetidos à biópsia de pele ou mucosa, teste de Montenegro e exame otorrinolaringológico; SbV (10 a 20mg/kg, no total de 10, 30 e 90 doses. foi empregado em 44 pacientes; em quatro casos, anfotericina B (0,5mg/kg/dose até dose cumulativa de 30mg/kg. RESULTADOS: 28 homens e 20 mulheres na faixa etária de 10 a 89 anos, dos quais 38 (79,1% infectados no Rio de Janeiro, apresentaram úlcera de membro inferior e comprometimento de mucosa nasal como manifestações mais freqüentes; 41 casos (85,4% foram reatores à intradermorreação de Montenegro (5mm; 17 casos (35,4% foram positivos para o achado de amastigotas em macrófagos no infiltrado inflamatório dérmico; predominou o processo inflamatório crônico granulomatoso; cura clínica foi observada em 47 casos; um caso evoluiu para óbito no décimo dia de tratamento. CONCLUSÕES: O estudo da leishmaniose tegumentar (HUCFF/UFRJ no período 1990/2002 evidenciou padrão conhecido nos aspectos epidemiológicos, clínicos e de resposta terapêutica ao antimonial (SbV e anfotericina B.BACKGROUND: American tegumentary Leishmaniasis is widely found in Brazil; the state of Rio de Janeiro (capital and hinterland is an endemic area where the vector is found inside and outside houses. OBJECTIVES: prospective study of 48 cases attended at the Teaching Hospital Clementino Fraga Filho - UFRJ, between 1990 - 2002. METHODS: All patients were submitted to skin or mucosa biopsy, Montenegro skin test and otorhinolaryngologic examination; SbV (10 - 20 mg/kg with 10, 30 and 90 doses was

  14. Evaluation of Red Light Camera Enforcement at Signalized Intersections

    Directory of Open Access Journals (Sweden)

    Abdulrahman AlJanahi

    2007-12-01

    Full Text Available The study attempts to find the effectiveness of adopting red light cameras in reducing red light violators. An experimental approach was adopted to investigate the use of red light cameras at signalized intersections in the Kingdom of Bahrain. The study locations were divided into three groups. The first group was related to the approaches monitored with red light cameras. The second group was related to approaches without red light cameras, but located within an intersection that had one of its approaches monitored with red light cameras. The third group was related to intersection approaches located at intersection without red light cameras (controlled sites. A methodology was developed for data collection. The data were then tested statistically by Z-test using proportion methods to compare the proportion of red light violations occurring at different sites. The study found that the proportion of red light violators at approaches monitored with red light cameras was significantly less than those at the controlled sites for most of the time. Approaches without red light cameras located within intersections having red light cameras showed, in general, fewer violations than controlled sites, but the results were not significant for all times of the day. The study reveals that red light cameras have a positive effect on reducing red light violations. However, these conclusions need further evaluations to justify their safe and economic use.

  15. Fisioterapia respiratória no pré-operatório de colecistectomia

    Directory of Open Access Journals (Sweden)

    Lucas Lima Ferreira

    2013-05-01

    Full Text Available Introdução: As cirurgias abdominais altas causam alterações da função pulmonar caracterizadas por redução da capacidade vital, relacionada à presença de hipoxemia e atelectasia, e pela  redução do volume expiratório forçado no primeiro segundo. Relato do caso: Paciente do sexo feminino, 29 anos, diagnóstico médico de cálculos biliares e hérnia hiatal, diagnóstico funcional de baixo desempenho cardiorrespiratório, a três meses de préoperatório de colecistectomia. Foi realizada avaliação composta por dados antropométricos, espirometria, teste de caminhada de seis minutos (TC6, mensuração das pressões respiratórias pIntrodução: As cirurgias abdominais altas causam alterações da função pulmonar caracterizadas por redução da capacidade vital, relacionada à presença de hipoxemia e atelectasia, e pela redução do volume expiratório forçado no primeiro segundo. Relato do caso: Paciente do sexo feminino, 29 anos, diagnóstico médico de cálculos biliares e hérnia hiatal, diagnóstico funcional de baixo desempenho cardiorrespiratório, a três meses de préoperatório de colecistectomia. Foi realizada avaliação composta por dados antropométricos, espirometria, teste de caminhada de seis minutos (TC6, mensuração das pressões respiratórias por meio da manovacuometria e do nível de qualidade de vida mediante o questionário SF-36. A seguir foi aplicado um protocolo de fisioterapia respiratória e reavaliação após o tratamento. Na avaliação inicial foi verificado que a paciente encontravase com sobrepeso (IMC=27,40 kg/m2, baixo desempenho cardiorrespiratório e fraqueza da musculatura respiratória. Conclusão: O protocolo aplicado mostrou-se eficaz, pois auxiliou na redução de peso corporal e melhorou o desempenho cardiorrespiratório por meio dos exercícios aeróbicos, e proporcionou ganho de força aos músculos respiratórios.

  16. Antibacterial Compounds from Red Seaweeds (Rhodophyta)

    OpenAIRE

    Noer Kasanah; Triyanto Triyanto; Drajad Sarwo Seto; Windi Amelia; Alim Isnansetyo

    2015-01-01

    Seaweeds produce great variety of metabolites benefit for human. Red seaweeds (Rhodophyta) are well known as producer of phycocolloids such agar, agarose, carragenan and great variety of secondary metabolites. This review discusses the red algal secondary metabolites with antibacterial activity. The chemical constituents of red algae are steroid, terpenoid, acetogenin and dominated by halogenated compounds mainly brominated compounds. Novel compounds with intriguing skeleton are also reported...

  17. Tipos do Herbário Prisco Bezerra - EAC

    Directory of Open Access Journals (Sweden)

    Maria Stela Bezerra da Silva

    1990-01-01

    Full Text Available Com o presente trabalho pretende-se contribuir para a divulgação dos tipos do Herbário Prisco Bezerra - EAC. Um levantamento realizado no acervo do Herbário revelou o registro de dez tipos. Sete deles pertencentes à família Leguminosae distribuídas entre as subfamilias Caesalpinioideae: Peltogyne crenulata, Sentia dardanoi, Moldenhawera acuminata, Chamaecrista duckeana, Papilionoideae: Aeschynomene monteiroi, Cranocarpus gracilis e Mimosoideae: Mimosa niomarlei; dois, pertencentes à família Erythroxylaceae. As espécies Erythroxylum tianguanum e Erythroxylum bezerrae e um à família Euphorbiaceae: Dalechampia fernandesii recentemente descrita por G. Webster. Os tipos são apresentados na seqüência das indicações: nome das famílias, seguido do epíteto específico, habitat, com a transferência de todas as informações mencionadas na ficha de exsicata do material, bem como, a fotografia correspondente. Citam-se também alguns aspectos característicos das espécies, para melhor visualização dos detalhes fotográficos.The present paper repasts the type specimens in the Herbário Prisco Bezerra (University of Ceará. The Herbário has ten type, of which seven are Leguminosae: Peltoqyne crenulata, Senna dardanoi, Moldenhawera acuminata Chamaecrista duckeana, Aeschynomene monteiroi, Cranocarpus gracilis, Mimosa niomarlei, two the Erythroxylaceae: Erythroxylum tianquanum and Erythroxylum bezerrae and one Euphorbiaceae: Dalechampia fernandesii. Additional informations for these exsicata is presented.

  18. Agentes Comunitários de Saúde: agenciadores de encontros entre territórios Community Health Workers: promoters of interaction between territories

    Directory of Open Access Journals (Sweden)

    Samira Lima da Costa

    2012-11-01

    Full Text Available O artigo apresenta reflexões produzidas a partir de uma série de encontros com Agentes Comunitários de Saúde, ao longo de dez anos. Identifica-se a consolidação de dois territórios existenciais, que ora se aproximam, ora se afastam: o do saber técnico em saúde e o do saber popular em saúde. A partir da análise de algumas falas de ACS e de reflexões que dialogam com o referencial teórico da área, o texto discute alguns dos dilemas e impasses do acesso e da adesão na ótica desses Agentes, bem como as estratégias cotidianamente inventadas a partir dos encontros que se dão entre esses dois territórios. Identifica-se o lugar do Agente Comunitário de Saúde como agenciador de fronteiras, atuando em alguns momentos como um inventor ou potencializador de zonas de contato entre territórios e, em outros, como um representante de um dos territórios no outro.This article presents reflections originating from a series of meetings with community health workers over a period of ten years. It identifies the consolidation of two existential territories, which are sometimes closer and at other times more distant from each other, namely the territory of technical knowledge about health and the territory of popular knowledge about health. Starting with the analysis of some quotes from health workers and reflections which tally with the theoretical reference in the area, this paper discusses some of the dilemmas and deadlocks of access and affiliation from the perspective of some of these health workers, as well as the strategies devised on a day-to-day basis from the crossovers that take place between these two territories. It identifies the function of community health workers as frontier agents, at times acting as inventors or motivators of contact zones between the territories, and at other times acting as a representative by one territory inside the other.

  19. Impacto do uso de microrganismos em caixas sifonadas de ambientes sanitários

    Directory of Open Access Journals (Sweden)

    Verena Soares Fernandes

    Full Text Available Resumo A preocupação com a qualidade de operação dos sistemas prediais de esgoto sanitário tem motivado empresas especializadas em biotecnologia a investir em produtos compostos por misturas de microrganismos vivos que atuam no pré-tratamento de efluentes de sistemas prediais para combater odores desagradáveis em ambientes sanitários. O objetivo deste artigo é avaliar o uso de misturas concentradas de microrganismos em caixas sifonadas para eliminar o mau cheiro em ambientes sanitários e o impacto em estações de tratamento de esgotos sanitários. O método consiste em diagnosticar o mau cheiro de um dos sanitários de um edifício escolar de nível superior, que é alvo de constantes reclamações por parte dos usuários. Em seguida, introduzir tabletes de microrganismos nas caixas sifonadas e, por fim, avaliar o impacto do uso desse produto em dois sanitários e em estações de tratamento de esgoto por meio de análises de demanda bioquímica de oxigênio e de testes de respirometria. Os resultados indicam que nestes ambientes sanitários o mau cheiro não foi reduzido com o emprego de tabletes de microrganismos e em Estações de Tratamento de Esgoto, na concentração indicada pelo fabricante, o produto não produziu alterações significativas nas características analisadas do esgoto.

  20. Behavioral interactions of penned red and arctic foxes

    Science.gov (United States)

    Rudzinski, D.R.; Graves, H.B.; Sargeant, A.B.; Storm, G.L.

    1982-01-01

    Expansion of the geographical distribution of red foxes (Vulpes vulpes) into the far north tundra region may lead to competition between arctic (Alopex lagopus) and red foxes for space and resources. Behavioral interactions between red and arctic foxes were evaluated during 9 trials conducted in a 4.05-ha enclosure near Woodworth, North Dakota. Each trial consisted of introducing a male-female pair of arctic foxes into the enclosure and allowing them to acclimate for approximately a week before releasing a female red fox into the enclosure, followed by her mate a few days later. In 8 of 9 trials, red foxes were dominant over arctic foxes during encounters. Activity of the arctic foxes decreased upon addition of red foxes. Arctic foxes tried unsuccessfully to defend preferred den, resting, and feeding areas. Even though the outcome of competition between red and arctic foxes in the Arctic is uncertain, the more aggressive red fox can dominate arctic foxes in direct competition for den sites and other limited resources.

  1. redMaGiC: selecting luminous red galaxies from the DES Science Verification data

    Energy Technology Data Exchange (ETDEWEB)

    Rozo, E. [Univ. of Arizona, Tucson, AZ (United States). et al.

    2016-05-30

    We introduce redMaGiC, an automated algorithm for selecting Luminous Red Galaxies (LRGs). The algorithm was developed to minimize photometric redshift uncertainties in photometric large-scale structure studies. redMaGiC achieves this by self-training the color-cuts necessary to produce a luminosity-thresholded LRG sam- ple of constant comoving density. Additionally, we demonstrate that redMaGiC photo-zs are very nearly as accurate as the best machine-learning based methods, yet they require minimal spectroscopic training, do not suffer from extrapolation biases, and are very nearly Gaussian. We apply our algorithm to Dark Energy Survey (DES) Science Verification (SV) data to produce a redMaGiC catalog sampling the redshift range z ϵ [0.2,0.8]. Our fiducial sample has a comoving space density of 10-3 (h-1Mpc)-3, and a median photo-z bias (zspec zphoto) and scatter (σz=(1 + z)) of 0.005 and 0.017 respectively.The corresponding 5σ outlier fraction is 1.4%. We also test our algorithm with Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8) and Stripe 82 data, and discuss how spectroscopic training can be used to control photo-z biases at the 0.1% level.

  2. EKA urbanistika osakond / Lilia del Rio

    Index Scriptorium Estoniae

    Rio, Lilia del

    2006-01-01

    Lilia del Rio magistritöö "Beyond the player's manual / Mänguõpetus edasijõudnutele. Experiencing the world (and the city) as a playground / Kogedes maailma (ja linna) mänguväljakuna". Juhendaja Andres Kurg

  3. A fragilidade do Ministério da Defesa brasileiro

    Directory of Open Access Journals (Sweden)

    Jorge Zaverucha

    2005-11-01

    Full Text Available O presente artigo apresenta os diversos momentos por que passou o Ministério da Defesa, desde sua criação no segundo mandato presidencial de Fernando Henrique Cardoso (1999-2002 até o atual governo de Luís Inácio Lula da Silva (2003-2006, com os respectivos ministros da Defesa. Visto como uma etapa importante na reconstitucionalização do país, na medida em que prevê a submissão dos comandantes das Forças Armadas a um ministro civil, e embora alguns analistas considerem que essa submissão de fato ocorre, procuramos indicar as resistências e as insubordinações militares ao poder civil, provenientes de um legado autoritário. Na medida em que o Ministério da Defesa não consegue implementar uma política própria, em que os militares seguiriam as orientações dos civis, o artigo conclui considerando a fragilidade política e institucional do Ministro da Defesa, civil, ante o os comandos militares, que conservam alto grau de autonomia decisória em relação à estrutura do Ministério.

  4. Produtos e serviços bancários

    OpenAIRE

    Álvaro Modernell

    2009-01-01

    Guia com informações sobre produtos e serviços bancários que estão à disposição dos cidadãos brasileiros com a finalidade de facilitar o seu dia-a-dia. O documento é uma cartilha educativa preparada para clientes da CAIXA, uma instituição pública de poupança e crédito. O guia foi produzido como parte do "Programa de Remessas e Capacitação para Emigrantes Brasileiros e seus Beneficiários no Brasil".

  5. Red and Green Fluorescence from Oral Biofilms.

    Science.gov (United States)

    Volgenant, Catherine M C; Hoogenkamp, Michel A; Krom, Bastiaan P; Janus, Marleen M; Ten Cate, Jacob M; de Soet, Johannes J; Crielaard, Wim; van der Veen, Monique H

    2016-01-01

    Red and green autofluorescence have been observed from dental plaque after excitation by blue light. It has been suggested that this red fluorescence is related to caries and the cariogenic potential of dental plaque. Recently, it was suggested that red fluorescence may be related to gingivitis. Little is known about green fluorescence from biofilms. Therefore, we assessed the dynamics of red and green fluorescence in real-time during biofilm formation. In addition, the fluorescence patterns of biofilm formed from saliva of eight different donors are described under simulated gingivitis and caries conditions. Biofilm formation was analysed for 12 hours under flow conditions in a microfluidic BioFlux flow system with high performance microscopy using a camera to allow live cell imaging. For fluorescence images dedicated excitation and emission filters were used. Both green and red fluorescence were linearly related with the total biomass of the biofilms. All biofilms displayed to some extent green and red fluorescence, with higher red and green fluorescence intensities from biofilms grown in the presence of serum (gingivitis simulation) as compared to the sucrose grown biofilms (cariogenic simulation). Remarkably, cocci with long chain lengths, presumably streptococci, were observed in the biofilms. Green and red fluorescence were not found homogeneously distributed within the biofilms: highly fluorescent spots (both green and red) were visible throughout the biomass. An increase in red fluorescence from the in vitro biofilms appeared to be related to the clinical inflammatory response of the respective saliva donors, which was previously assessed during an in vivo period of performing no-oral hygiene. The BioFlux model proved to be a reliable model to assess biofilm fluorescence. With this model, a prediction can be made whether a patient will be prone to the development of gingivitis or caries.

  6. Red and Green Fluorescence from Oral Biofilms.

    Directory of Open Access Journals (Sweden)

    Catherine M C Volgenant

    Full Text Available Red and green autofluorescence have been observed from dental plaque after excitation by blue light. It has been suggested that this red fluorescence is related to caries and the cariogenic potential of dental plaque. Recently, it was suggested that red fluorescence may be related to gingivitis. Little is known about green fluorescence from biofilms. Therefore, we assessed the dynamics of red and green fluorescence in real-time during biofilm formation. In addition, the fluorescence patterns of biofilm formed from saliva of eight different donors are described under simulated gingivitis and caries conditions. Biofilm formation was analysed for 12 hours under flow conditions in a microfluidic BioFlux flow system with high performance microscopy using a camera to allow live cell imaging. For fluorescence images dedicated excitation and emission filters were used. Both green and red fluorescence were linearly related with the total biomass of the biofilms. All biofilms displayed to some extent green and red fluorescence, with higher red and green fluorescence intensities from biofilms grown in the presence of serum (gingivitis simulation as compared to the sucrose grown biofilms (cariogenic simulation. Remarkably, cocci with long chain lengths, presumably streptococci, were observed in the biofilms. Green and red fluorescence were not found homogeneously distributed within the biofilms: highly fluorescent spots (both green and red were visible throughout the biomass. An increase in red fluorescence from the in vitro biofilms appeared to be related to the clinical inflammatory response of the respective saliva donors, which was previously assessed during an in vivo period of performing no-oral hygiene. The BioFlux model proved to be a reliable model to assess biofilm fluorescence. With this model, a prediction can be made whether a patient will be prone to the development of gingivitis or caries.

  7. The Transport of Gmelina Logs on the Rio Dulce

    Energy Technology Data Exchange (ETDEWEB)

    Ensminger, J.T.; Martines, R.; Perlack, B.; Ranney, J.

    1997-02-01

    The Rio Dulce National Park is one of Guatemala's major environmental assets. The park contains the remaining remnants of an eastern Guatemalan tropical rainforest which has good but fast deteriorating value for the development of the ecotourism industry. The governmenial objective for the region as stated in the Master Plan for the park is ecotourism development and protection of biodiversity. The decisions to be made concerning the long-term, sustainable use of the natural resources of the Rio Dulce region appear to be directed by existing environmental laws and the Rio Dulce Master Plan. However, the wording of these instruments is ambiguous and lacks specific definitions and criteria for making necessary determinations. This, in combination with lack of enforcement in the region, has led to extensive disparity in interpretation of the laws and uncontrolled, conflicting actions by individuals and organizations.

  8. Avaliação do controle externo da qualidade nos laboratórios clínicos do Rio de Janeiro de 2006 a 2008 Evaluation of external quality assessment in clinical laboratories from Rio de Janeiro in the years 2006-2008

    Directory of Open Access Journals (Sweden)

    Josefa Sieira Caamaño Chaves

    2010-10-01

    Full Text Available INTRODUÇÃO: O Controle Externo da Qualidade (CEQ é uma ferramenta importante para a garantia da qualidade das análises laboratoriais, auxiliando o laboratório a avaliar a eficiência da fase analítica de seus processos. Um resultado errôneo de uma análise prejudica a conclusão do diagnóstico de uma enfermidade e a indicação correta do tratamento a ser tomado. As inspeções sanitárias em laboratórios clínicos (LCs no estado do Rio de Janeiro são feitas com base no roteiro de inspeção sanitária publicado pela Portaria SES/CVS 743, de junho de 2006, na RDC 302/2005 e legislação vigente. Os resultados observados quanto ao CEQ, do total de 347 inspeções realizadas pelo Setor de Laboratórios de Análises Clínicas da Secretaria de Saúde e Defesa Civil (LAC-SESDEC no decorrer dos anos pesquisados, são apresentados a seguir: em 2006, entre as 133 inspeções realizadas em Laboratórios de Análises Clínicas, 44% dos estabelecimentos não possuíam contrato com provedor de ensaios de proficiência (EPs; em 2007, entre as 95 inspeções realizadas em Laboratórios de Análises Clínicas, 38% não possuíam contrato com provedor de EPs; em 2008, entre as 119 inspeções realizadas em Laboratórios de Análises Clínicas, 35% não possuíam contrato com provedor de EPs. Dos 214 laboratórios clínicos inspecionados nos anos de 2007 e 2008, 62% (134 estabelecimentos possuíam CEQ, entretanto, desses 134 estabelecimentos, 65% não registravam as ações corretivas relacionadas com as não conformidades detectadas em relatório emitido pelo provedor de EPs. MÉTODO: No presente estudo, foi avaliada a distribuição percentual dos resultados das inspeções sanitárias realizadas em LCs no estado do Rio de Janeiro de 2006 a 2008, cadastrados na Secretaria Estadual de Saúde e Defesa Civil (SESDEC, relacionando o número de LCs que não atendem às exigências sanitárias, item: "Controle Externo da Qualidade - CEQ da Portaria 743

  9. Simulation of the three-dimensional distribution of the red:far-red ratio within crop canopies

    NARCIS (Netherlands)

    Chelle, M.; Evers, J.B.; Combes, D.; Varlet-Grancher, C.; Vos, J.; Andrieu, B.

    2007-01-01

    It is widely recognized that the red:far-red ratio (zeta) acts as a signal that triggers plant morphogenesis. New insights into photomorphogenesis have been gained through experiments in controlled environments. Extrapolation of such results to field conditions requires characterization of the zeta

  10. A expansão dos poderes judiciários The expansion of the judiciary powers

    Directory of Open Access Journals (Sweden)

    Lilia Ferreira Lobo

    2012-01-01

    Full Text Available O presente artigo propõe-se a comentar um texto de Foucault pouco conhecido e que não foi incluído na publicação francesa dos Ditos e Escritos. Além de apresentar esta publicação, que tem como título La redéfinition du judiciable (A redefinição do judiciável, pretende trazer algumas considerações sobre as questões sugeridas por Foucault, bem como algumas indicações sobre o que hoje nos acontece em termos da judicialização do nosso cotidiano. O texto traz uma análise do papel da justiça, daquilo que vem se tornando ou que é objeto de julgamento judiciário, discutindo o que caracteriza a difusão das funções judiciárias através de todo o corpo social na atualidade.This article aims to comment an unfamiliar article by Foucault, not included in the french edition of Dits et Écrits. Beyond presenting this publication, which is entitled La redéfinition du judiciable (The redefinition of the judiciable, it pretends to bring some considerations about the questions that Foucault suggests, as well as some indications about what is happening with us now-a-days in terms of the judicialization of the everyday life. The text brings an analysis of the roll of justice, of what is turning into or what is the object of judiciary judgment, discussing the elements which characterize the diffusion of the judiciary functions through the whole social body.

  11. Ajustamento EstratÃgico do Setor BancÃrio ao Plano Real

    OpenAIRE

    Maria Elisangela Rodrigues dos Santos

    2004-01-01

    Este estudo evendicia as transformaÃÃes ocorridas no setor bancÃrio apÃs o Plano Real, originado em 01 de Julho de 1994. Essas transformaÃÃes proporcionaram impactos no sistema bancÃrio, dando inÃcio a um amplo processo de reforma estrutural ocasionado por modificaÃÃes de aÃÃes exÃgenas macroeconÃmicas. Com inÃcio do Plano, sabia-se que o novo ambiente de estabilizaÃÃo econÃmico do paÃs nÃo seria condizente com a dimensÃo que o sistema bancÃrio havia alcanÃado, fruto de vÃrios anos de inflaÃÃ...

  12. Índices plaquetários em indivíduos com doença hepática alcoólica crônica Platelet indices in chronic alcoholic liver disease patients with thrombocytopenia

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Costa

    2007-09-01

    Full Text Available OBJETIVO: Detectar alterações nos índices plaquetários em indivíduos com doença hepática alcoólica crónica e trombocitopenia e determinar o seu grau de correlação com outros parâmetros hematológicos. MÉTODOS: Foram estudados um total de 65 indivíduos, divididos em dois grupos: controlos (n = 35 e com doença hepática alcoólica crónica e trombocitopenia (n = 30. O grupo controlo foi emparelhado por idade e sexo com o grupo de doentes. A todos eles, foi efectuado hemograma completo, incluindo índices plaquetários. RESULTADOS: Os doentes com doença hepática alcoólica crónica apresentaram contagem de eritrócitos, leucócitos e plaquetas significativamente inferiores aos encontrados na população controlo. O mesmo se verificou com os valores de hemoglobina, hematócrito e valores absolutos de linfócitos e neutrófilos. O volume globular médio, a hemoglobina globular média e o RDW ("red cell distribution width" revelaram-se significativamente superiores no grupo de doentes. Relativamente aos índices plaquetários, foi encontrado aumento estatisticamente significativo do PDW ("platelet distribution width" e uma diminuição estatisticamente significativa no plaquetrócrito no grupo de doentes quando comparado com o grupo controlo. Em relação ao volume plaquetário médio não se encontraram diferenças estatisticamente significativas entre os dois grupos. Foi encontrada correlação estatisticamente significativa entre a contagem de plaquetas e os outros parâmetros hematológicos analisados. O plaquetrócito revelou-se o índice plaquetário que mais se relaciona com os restantes parâmetros hematológicos. CONCLUSÃO: Os doentes com doença hepática alcoólica crónica apresentam diminuição nas três linhas hematopoiéticas, possivelmente associada com o hiperesplenismo que estes doentes apresentam. Adicionalmente às alterações numéricas, encontraram-se alterações morfológicas a nível dos eritrócitos e

  13. Exploratory Practice: Work at the Cultural Inglesa, Rio de Janeiro, Brazil.

    Science.gov (United States)

    Allwright, Dick; Lenzuen, Rosa

    1997-01-01

    Focuses on the aim of the Cultural Inglesa, Rio de Janeiro, Brazil, which is the development of a new, fully sustainable concept for classroom-based research--exploratory practice--and its assimilation into the normal working and professional-development practices of Rio Cultura teachers. (Author/VWL)

  14. Heating effects in Rio Blanco rock

    International Nuclear Information System (INIS)

    Taylor, R.W.; Bowen, D.W.; Rossler, P.E.

    1975-01-01

    Samples of ''sandstone'' from near the site of the upper Rio Blanco nuclear explosion were heated in the laboratory at temperatures between 600 and 900 0 C. The composition and amount of noncondensable (dry) gas released were measured and compared to the amount and composition of gas found underground following the explosion. The gas released from the rock heated in the laboratory contained approximately 80 percent CO 2 and 10 percent H 2 ; the balance was CO and CH 4 . With increasing temperature, the amounts of CO 2 , CO, and H 2 released increased. The composition of gas released by heating Rio Blanco rock in the laboratory is similar to the composition of gas found after the nuclear explosion except that it contains less natural gas (CH 4 , C 2 H 6 . . .). The amount of noncondensable gas released by heating the rock increases from approximately 0.1 mole/kg of rock at 600 0 C to 0.9 mole/kg at 900 0 C. Over 90 percent of the volatile components of the rock are released in less than 10 h at 900 0 C. A comparison of the amount of gas released by heating rock in the laboratory to the amount of gas released by the heat of the Rio Blanco nuclear explosion suggests that the explosion released the volatile material from about 0.42 mg of rock per joule of explosive energy (1700 to 1800 tonnes per kt). (auth)

  15. Red and green fluorescence from oral biofilms

    NARCIS (Netherlands)

    Volgenant, C.M.C.; Hoogenkamp, M.A.; Krom, B.P.; Janus, M.M.; ten Cate, J.M.; de Soet, J.J.; Crielaard, W.; van der Veen, M.H.

    2016-01-01

    Red and green autofluorescence have been observed from dental plaque after excitation by blue light. It has been suggested that this red fluorescence is related to caries and the cariogenic potential of dental plaque. Recently, it was suggested that red fluorescence may be related to gingivitis.

  16. A new species of Hisonotus (Siluriformes, Loricariidae from rio São Francisco basin, Brazil

    Directory of Open Access Journals (Sweden)

    Fábio Roxo

    2015-04-01

    Full Text Available A new species of Hisonotus is described from the rio São Francisco basin. The new species can be distinguished from congeners by having (1 a unique coloration pattern of caudal fin with one black spot extending from its origin to the ventral lobe and two dark spots at the end of the lobe’s rays; (2 odontodes forming longitudinally aligned rows on head and trunk; (3 a functional V-shaped spinelet; (4 a single rostral plate at the tip of the snout; (5 by lacking contrasting dark geometric spots on the anterodorsal region of the body; (6 a lower caudal-peduncle depth; and (7 lower counts of the lateral median plates and (8 higher premaxillary and dentary teeth. The new species is the second described species of the genus Hisonotus in the rio São Francisco basin. It was found inhabiting the marginal vegetation of the rio São Francisco and three of its tributary, rio das Velhas, rio Paraopeba and rio Formoso.

  17. Morphological diversity of fish along the rio das Velhas, Minas Gerais, Brazil

    Directory of Open Access Journals (Sweden)

    Nara Tadini Junqueira

    2012-01-01

    Full Text Available The rio das Velhas, located in central Minas Gerais State (Brazil, is a major tributary of the rio São Francisco. Despite several anthropogenic pressures, this basin supports more than 115 fish species. The aim of this study was to compare the morphological space occupied by fish assemblages in four regions (headwaters, upper, middle, and lower course along the channel of the rio das Velhas. We try to answer the following question: Is there a change in the morphological organization of the fish along the longitudinal gradient of the river? Individuals from 67 species, collected at several sites in the basin from 1999 to 2008, were measured for 11 morphological attributes related to swimming behavior and habitat use. Through the graphs, the first two dimensions of the PCA suggest that the morphological volume occupied by the headwaters region is smaller than the other sections, because of the low richness of the site. However, morphological hypervolumes of the four reaches analyzed by Euclidean distances were not statistically different. The results indicated that only the density of morphological types increases along the rio das Velhas, and there is no difference between the headwaters and upper courses. Therefore, in order to use functional groups related to the morphology of the species as tools to take measures for the conservation and revitalization of the rio das Velhas, it is necessary analyze the density of species within these groups, as well as their composition.O rio das Velhas, localizado na região central do estado de Minas Gerais (Brasil, é o mais extenso tributário do rio São Francisco. Apesar dos inúmeros impactos antrópicos que sofre, sua bacia abriga uma rica ictiofauna, com mais de 115 espécies conhecidas. O objetivo deste estudo foi comparar o espaço morfológico ocupado pelas assembleias de peixes em quatro regiões (cabeceira, alto curso, médio curso e baixo curso ao longo da calha do rio das Velhas. Procuramos

  18. Don't Take This with That!

    Medline Plus

    Full Text Available ... squeeze…especially when combining grapefruit with medicines. While it can be part of a balanced and nutritious diet, grapefruit can have serious consequences when taken with certain medications. Currently, there are ...

  19. Stockpiling and Comprehensive Utilization of Red Mud Research Progress

    Science.gov (United States)

    Liu, Dong-Yan; Wu, Chuan-Sheng

    2012-01-01

    With increasing production of red mud, the environmental problems caused by it are increasingly serious, and thus the integrated treatment of red mud is imminent. This article provides an overview of the composition and the basic characteristics of red mud. The research progress of safe stockpiling and comprehensive utilization of red mud is summarized. The safe stockpiling of red mud can be divided into two aspects: the design and safe operation of the stocking yard. The comprehensive utilization of red mud can be further divided into three aspects: the effective recycling of components, resource utilization and application in the field of environmental protection. This paper points out that the main focus of previous studies on red mud stockpiling is cost reproduction and land tenure. The recovery of resources from red mud has a high value-added, but low level industrialization. The use of red mud as a building material and filler material is the most effective way to reduce the stockpiling of red mud. Red mud used for environmental remediation materials is a new hotspot and worth promoting for its simple processing and low cost.

  20. Red algae and their use in papermaking.

    Science.gov (United States)

    Seo, Yung-Bum; Lee, Youn-Woo; Lee, Chun-Han; You, Hack-Chul

    2010-04-01

    Gelidialian red algae, that contain rhizoidal filaments, except the family Gelidiellaceae were processed to make bleached pulps, which can be used as raw materials for papermaking. Red algae consist of rhizoidal filaments, cortical cells usually reddish in color, and medullary cells filled with mucilaginous carbohydrates. Red algae pulp consists of mostly rhizoidal filaments. Red algae pulp of high brightness can be produced by extracting mucilaginous carbohydrates after heating the algae in an aqueous medium and subsequently treating the extracted with bleaching chemicals. In this study, we prepared paper samples from bleached pulps obtained from two red algae species (Gelidium amansii and Gelidium corneum) and compared their properties to those of bleached wood chemical pulps. Copyright 2009 Elsevier Ltd. All rights reserved.

  1. ANÁLISE DE CONTEÚDO DOS ITENS OBRIGATÓRIOS OU RECOMENDADOS E DE DIVULGAÇÃO ESPONTÂNEA NO RELATÓRIO DA ADMINISTRAÇÃO DAS COMPANHIAS ABERTAS

    Directory of Open Access Journals (Sweden)

    ALESSANDRA VASCONCELOS GALLON

    2008-04-01

    Full Text Available O artigo descreve a análise de conteúdo da evidenciação nos Relatórios da Administração das empresas participantes dos níveis de governança da Bovespa, relacionada aos itens obrigatórios pela Lei nº 6.404/76, recomendados pela CVM através do Parecer de Orientação nº 15/87 e outros itens de divulgação espontânea. A pesquisa caracteriza-se como descritiva, realizada por meio de análise documental, com análise de clusters. Os resultados mostram que as 55 companhias abertas brasileiras, participantes do nível 1 e 2 de governança e novo mercado da Bovespa, segundo o BDI nº 190/2005, independente do nível de governança, evidenciaram no Relatório de Administração de 2004 mais sentenças do tipo declarativa. Comparando-se o número de sentenças evidenciadas de itens obrigatórios e recomendados e de itens de divulgação espontânea, nota-se que a maior evidenciação é referente aos itens obrigatórios e recomendados. Conclui-se que os Relatórios da Administração das companhias abertas brasileiras apresentam níveis relativamente baixos de evidenciação voluntária.

  2. Y-Chromosome Markers for the Red Fox.

    Science.gov (United States)

    Rando, Halie M; Stutchman, Jeremy T; Bastounes, Estelle R; Johnson, Jennifer L; Driscoll, Carlos A; Barr, Christina S; Trut, Lyudmila N; Sacks, Benjamin N; Kukekova, Anna V

    2017-09-01

    The de novo assembly of the red fox (Vulpes vulpes) genome has facilitated the development of genomic tools for the species. Efforts to identify the population history of red foxes in North America have previously been limited by a lack of information about the red fox Y-chromosome sequence. However, a megabase of red fox Y-chromosome sequence was recently identified over 2 scaffolds in the reference genome. Here, these scaffolds were scanned for repeated motifs, revealing 194 likely microsatellites. Twenty-three of these loci were selected for primer development and, after testing, produced a panel of 11 novel markers that were analyzed alongside 2 markers previously developed for the red fox from dog Y-chromosome sequence. The markers were genotyped in 76 male red foxes from 4 populations: 7 foxes from Newfoundland (eastern Canada), 12 from Maryland (eastern United States), and 9 from the island of Great Britain, as well as 48 foxes of known North American origin maintained on an experimental farm in Novosibirsk, Russia. The full marker panel revealed 22 haplotypes among these red foxes, whereas the 2 previously known markers alone would have identified only 10 haplotypes. The haplotypes from the 4 populations clustered primarily by continent, but unidirectional gene flow from Great Britain and farm populations may influence haplotype diversity in the Maryland population. The development of new markers has increased the resolution at which red fox Y-chromosome diversity can be analyzed and provides insight into the contribution of males to red fox population diversity and patterns of phylogeography. © The American Genetic Association 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. TERRITÓRIOS ALTERNATIVOS: ESPAÇOS FRONTEIRIÇOS E TRANSFRONTEIRIÇOS

    Directory of Open Access Journals (Sweden)

    Jurany Leite Rueda

    2017-06-01

    Full Text Available O livro (Territórios Alternativos é uma coletânea resultante da trajetória do autor pelas trilhas da Geografia, e cobre o período de 1987 a 1998, promovendo um panorama sobre as discussões à volta do espaço geográfico e do território em suas diferentes dimensões.

  4. Avaliação da cv. Tannat para elaboração de vinho tinto Evaluation of cv. Tannat to elaborate red wine

    Directory of Open Access Journals (Sweden)

    Luiz Antenor Rizzon

    2004-06-01

    Full Text Available A uva Tannat, originária do Sudoeste da França, foi introduzida no Rio Grande do Sul, pela Estação Experimental de Caxias do Sul. É uma cultivar difundida na Serra Gaúcha para elaboração de vinho tinto, utilizado para corte e para a produção de vinho varietal. O objetivo do presente trabalho foi avaliar o potencial enológico da cv. Tannat para a elaboração de vinho tinto fino nessa região vitícola. Para isso, realizaram-se estudos para caracterizar o cacho, o mosto e o vinho nas safras de 1987 a 1994, a partir de um vinhedo localizado em Bento Gonçalves, RS. Os resultados evidenciaram que a cv. Tannat tem cacho com peso médio de 216,1g e baga esférica pequena (1,54g. O mosto apresenta teor elevado de acidez titulável (155meq/L-1. O vinho se caracteriza por teores elevados em: polifenóis totais (I 280= 43,0, taninos (1,9g/L, antocianinas (539mg/L, potássio (1.856mg/L-1 e soma dos álcoois superiores (512mg/L-1. As características sensoriais do vinho Tannat na Serra Gaúcha evidenciam uma cor vermelha-violácea intensa, tânicos, nervosos, relativamente duros e aromas de frutas vermelhas. É recomendável para corte com outros vinhos tintos finos para intensificar sua cor e estrutura e também para a produção de vinho varietal podendo melhorar com o amadurecimento em barricas de carvalho.The Tannat grape is native to the Southwest of France, and was introduced into the State of Rio Grande do Sul by the Caxias do Sul Experimental Station. It is a cultivar diffused in the Serra Gaucha region with the purpose of elaborating varietal red wine for blending. The purpose of this work was to evaluate the enological potential of the Tannat grape for red wine in this region. To achieve this objective, variables related to the berries, clusters, must, and wine were evaluated from the 1987 to 1994 vintages, in a vineyard established in Bento Gonçalves, RS, Brazil. The results showed that Tannat grapes have large clusters (216.1g and

  5. Mortalidade por tuberculose e indicadores sociais no município do Rio de Janeiro Tuberculosis mortality and social indicatory in Rio de Janeiro city

    Directory of Open Access Journals (Sweden)

    Genésio Vicentin

    2002-01-01

    Full Text Available Este artigo estuda a mortalidade por tuberculose no município do Rio de Janeiro ocorrida no ano de 1991 em comparação com indicadores sociais. Utilizou-se o software SPSS 8.0 - 1997 na análise estatística dos dados, que mostrou a existência de correlação entre a maioria dos indicadores socioeconômicos estudados e o coeficiente de mortalidade por tuberculose por 100 mil habitantes/ano. Apresentaram correlação significativa e direta os indicadores: índice de Robin Hood, razão de renda entre os 10% mais ricos e os 40% mais pobres e proporção de chefes de família com renda média entre um e dois salários mínimos. A correlação foi inversa e significativa com os indicadores: proporção de residentes com mais de 10 anos com curso superior, área média por domicílio, número de cômodos por domicílio, renda média em salários mínimos, e proporção de chefes de família com rendas entre 10-15, 16-20 e acima de 20 salários mínimos. Para a apresentação destes indicadores usou-se mapas do município, categorizados e distribuídos por Regiões Administrativas, revelando distintos Rios de Janeiro, quando este é visto sob o ângulo social: da doença, ou de vários outros indicadores.Regional tuberculosis mortality levels and their Rio de Janeiro City principals social indicatories at year 1991 have been compared in this study. Software SPSS 8.0 - 1997 was applied on making statistical data analysis, and have disclosed a present correlation among most indicative socioeconomics trends and the annual tuberculosis mortality coeficient/100 thousand inhabitants. Others social indicatives than Robin Hood index, 10% more rich to 40% more poor reason, head of family proportion wich 1-2 minimum wage monthly gain, disclosed imediate and significative statistical assurance level. In reverse and significative statistical assurance level, resident proportion with more 10 years old that have superior course, house área average, room average

  6. Repositórios institucionais de acesso livre no Brasil: estudo Delfos

    Directory of Open Access Journals (Sweden)

    Ernani Rufino dos Santos Junior

    2015-06-01

    Full Text Available A filosofia do acesso livre ao conhecimento científico surgiu da dificuldade das bibliotecas universitárias de todo mundo em manter atualizadas as assinaturas das coleções de periódicos científicos. Os repositórios institucionais são uma das ferramentas que se mostram como alternativa para a comunicação da Ciência livre de barreiras de acesso. A pesquisa tem por objetivo verificar quais são as perspectivas futuras das atuais políticas de implementação de repositórios institucionais de acesso livre no Brasil na opinião de especialistas na área, tendo como base a análise do estado da arte das implementações de Repositórios Institucionais no Brasil. Neste trabalho, a pesquisa é dividida em três etapas: a primeira consiste na coleta de dados descritivos dos repositórios institucionais da Universidade de Brasília (RIUnB e do Superior Tribunal de Justiça (BDJur-STJ; já na segunda etapa de pesquisa, procede-se à consulta aos especialistas indagando-os acerca da situação atual das implementações de repositórios institucionais no Brasil; e, por fim, na terceira etapa de pesquisa consultamos estes mesmos especialistas sobre os desdobramentos futuros destas políticas no País. Utilizamos da técnica Delfos de pesquisa, onde os especialistas são consultados através de questionários constituídos de perguntas abertas, possibilitando assim chegar a um consenso das opiniões no final da pesquisa. Como resultado da pesquisa, é elaborado um quadro com a tabulação das respostas dos especialistas consultados revelando o panorama das perspectivas futuras das implementações de repositórios institucionais no Brasil na opinião dos especialistas que fazem parte da nossa amostra de pesquisa.

  7. 7 CFR 29.3052 - Red color (R).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Red color (R). 29.3052 Section 29.3052 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Red color (R). A brownish red. [24 FR 8771, Oct. 29, 1959. Redesignated at 47 FR 51722, Nov. 17, 1982...

  8. In vivo red blood cell compatibility testing using indium-113m tropolone-labeled red blood cells

    International Nuclear Information System (INIS)

    Morrissey, G.J.; Gravelle, D.; Dietz, G.; Driedger, A.A.; King, M.; Cradduck, T.D.

    1988-01-01

    In vivo radionuclide crossmatch is a method for identifying compatible blood for transfusion when allo- or autoantibodies preclude the use of conventional crossmatching techniques. A technique for labeling small volumes of donor red blood cells with [/sup 113m/In]tropolone is reported. The use of /sup 113m/In minimizes the accumulation of background radioactivity and the radiation dose especially so when multiple crossmatches are performed. Labeling red cells with [/sup 113m/In]tropolone is faster and easier to perform than with other radionuclides. Consistently high labeling efficiencies are obtained and minimal /sup 113m/In activity elutes from the labeled red blood cells. A case study involving 22 crossmatches is presented to demonstrate the technique. The radiation dose equivalent from /sup 113m/In is significantly less than with other radionuclides that may be used to label red cells

  9. A prova no processo administrativo tributário

    Directory of Open Access Journals (Sweden)

    Adriano Ribeiro Caldas

    2014-12-01

    Full Text Available O objetivo deste trabalho é discutir o papel da prova no âmbito do processo administrativo tributário, assim como os limites para a sua apresentação e a distribuição do ônus de sua produção. Para tanto, serão analisados os institutos da preclusão e da presunção, partindo-se sempre dos princípios aplicáveis ao processo administrativo tributário, notadamente os princípios do devido processo legal, da verdade material e do formalismo moderado.

  10. 7 CFR 29.1044 - Orange Red (FR).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

  11. Interactieve ontwerpmethodieken voor integrale duurzaamheid Toepassing van RIO in een aantal niet-veehouderij-gebonden cases

    NARCIS (Netherlands)

    Bos, A.P.; Annevelink, E.; Bos, H.L.; Keijsers, E.R.P.; Maas, van der M.P.; Poot, E.H.; Vermeulen, T.; Raaphorst, M.G.M.; Maas, van der A.A.; Schoorlemmer, H.B.; Dijk, van S.M.

    2013-01-01

    RIO (Reflexief Interactief Ontwerpen) bestaat uit drie hoofdonderdelen: de (systeem)analysefase, de ontwerpfase en de verankeringsfase. RIO is ontstaan in een veehouderijcontext. Die context heeft een aantal specifieke eigenschappen, die toepassing van RIO in andere sectoren niet volledig

  12. Comparison of bloat potential between a variety of soft-red versus a variety of hard-red winter wheat forage.

    Science.gov (United States)

    Akins, M S; Kegley, E B; Coffey, K P; Caldwell, J D; Lusby, K S; Moore, J C; Coblentz, W K

    2009-10-01

    Some aspects of wheat pasture bloat have been researched extensively, but few studies have evaluated the effect of wheat type or variety on bloat. Eight Gelbvieh x Angus ruminally cannulated heifers (515 +/- 49 kg of BW) and 48 Angus heifers (238 +/- 12 kg of BW) grazed 1-ha pastures of hard-red or soft-red winter wheat (Triticum aestivum L.) to evaluate the effect of wheat variety on bloat potential. In Exp. 1, cattle grazed from November 11 to 22 and from November 26 to December 7, 2006, in a crossover design. In Exp. 2, cattle were shrunk for 20 h and then grazed from December 19 to 20, 2006, and from January 19 to 20, 2007. In both experiments, bloat was scored at 1000 and 1600 h daily. Rumen samples were collected at 0600, 1200, and 1800 h during each of the last 2 d of each period in Exp. 1 and during both days of each period of Exp. 2. Rumen samples were evaluated for pH, foam production and strength, and viscosity. In Exp. 1, cannulated heifers grazing soft-red had a greater (P bloat (21.9 vs. 5.6%) than those grazing hard-red winter wheat, but bloat incidence was low (2.1%) for the stocker cattle, with no difference between hard-red and soft-red winter wheat (P = 0.52). Viscosity of the rumen fluid was affected (P = 0.03) by the wheat variety x time interaction, with soft-red at 1200 and 1800 h being more viscous than soft-red at 0600 h and hard-red at all times. Foam strength, as determined by bubbling CO(2) gas through rumen fluid, had a wheat variety x time interaction (P = 0.02) with both wheat varieties similar at 0600 h but soft-red having greater foam strength at 1200 and 1800 h. In Exp. 2, no bloat was observed, and no differences between wheat varieties were observed for any of the rumen foam measures. Therefore, for these 2 varieties, the soft-red winter wheat had a greater bloat potential than the hard-red winter wheat based on results from the cannulated heifers, but no differences were observed in the frequency of bloat in stocker cattle. In

  13. The status of the name Alysium holtingii C. Agardh, a red alga described from Brazil, and a depiction of the type specimen

    Directory of Open Access Journals (Sweden)

    Michael J. Wynne

    2008-06-01

    Full Text Available The type specimen of the red alga Alysium holtingii C. Agardh, described from Brazil, is located in the Lund Herbarium, and it is depicted for the first time in a publication. It is taxonomically identical to Dichotomaria obtusata (J. Ellis and Solander Lamarck and thus can be treated as a later taxonomic synonym. Alysium is regarded as congeneric with Dichotomaria.O espécime tipo da alga vermelha Alysium holtingii C. Agardh, descrito para o Brasil, está localizado no Herbário Lund, e é aqui apresentado. Ele é taxonomicamente idêntico a Dichotomaria obtusata (J. Ellis e Solander Lamarck e portanto deve ser tratado como um sinônimo taxonômico posterior. Alysium é considerado como congenérico com Dichotomaria.

  14. Utilization of red mud and Pb/Zn smelter waste for the synthesis of a red mud-based cementitious material.

    Science.gov (United States)

    Li, Yuan-Cheng; Min, Xiao-Bo; Ke, Yong; Chai, Li-Yuan; Shi, Mei-Qing; Tang, Chong-Jian; Wang, Qing-Wei; Liang, Yan-Jie; Lei, Jie; Liu, De-Gang

    2018-02-15

    A new method in which Pb/Zn smelter waste containing arsenic and heavy metals (arsenic sludge), red mud and lime are utilized to prepare red mud-based cementitious material (RCM) is proposed in this study. XRD, SEM, FTIR and unconfined compressive strength (UCS) tests were employed to assess the physicochemical properties of RCM. In addition, ettringite and iron oxide-containing ettringite were used to study the hydration mechanism of RCM. The results show that the UCS of the RCM (red mud+arsenic sludge+lime) was higher than that of the binder (red mud+arsenic sludge). When the mass ratio of m (binder): m (lime) was 94:6 and then maintained 28days at ambient temperature, the UCS reached 12.05MPa. The red mud has potential cementitious characteristics, and the major source of those characteristics was the aluminium oxide. In the red mud-arsenic sludge-lime system, aluminium oxide was effectively activated by lime and gypsum to form complex hydration products. Some of the aluminium in ettringite was replaced by iron to form calcium sulfoferrite hydrate. The BCR and leaching toxicity results show that the leaching concentration was strongly dependent on the chemical speciation of arsenic and the hydration products. Therefore, the investigated red mud and arsenic sludge can be successfully utilized in cement composites to create a red mud-based cementitious material. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. The Red Book through the ages.

    Science.gov (United States)

    Pickering, Larry K; Peter, Georges; Shulman, Stanford T

    2013-11-01

    The first edition of the Red Book was published in 1938. Since then, there have been numerous advances in the fields of infectious diseases and public health that have decreased morbidity and mortality of infants, children, and adolescents. Over the years, emerging pathogens and disease complexes have been described, sophisticated diagnostic techniques developed, advances in antimicrobial therapy have occurred, and immunizations have been implemented to prevent previously deadly diseases. Of the 18 diseases or organisms in the 1938 edition, 13 are now vaccine-preventable. Since inception of the Red Book, the aims of the editors have been to keep pace with these innovations and to continue to inform the medical community. These goals have made the Red Book a fundamental resource for pediatricians and other health care professionals in terms of guiding diagnosis, therapy, and prevention of infectious diseases. The list of 18 diseases or organisms originally described in the 1938 Red Book has expanded to include over 160 diseases or organisms in the 2012 edition. The pace of biomedical discovery, as well as the amount of information available and the number of methods for its delivery, will continue to accelerate in the future. Integration of information into future editions of the Red Book will ensure that practitioners continue to rely on the Red Book in its various electronic formats for clinical guidance and support.

  16. Grupos musicais em saúde mental: Atores em ação no cenário da reforma psiquiátrica no Rio de Janeiro/Brasil

    Directory of Open Access Journals (Sweden)

    João Arriscado Nunes

    2012-10-01

    Full Text Available O artigo investiga a formação de grupos musicais com usuários dos serviços de saúde mental da cidade do Rio de Janeiro. As seguintes questões norteiam a pesquisa: a qual é a relação entre tais grupos musicais e outros dispositivos grupais de tratamento, como a musicoterapia?; b como lidam esses grupos com a inclusão social dos usuários dos serviços?; c e como lidam com a renda gerada pelos CDs gravados e pelos shows?; d que efeitos produz a visibilidade dos grupos nas mídias televisiva, impressa e outras? A pesquisa de campo foi realizada com o referencial da teoria ator‑rede e se centrou em dois grupos musicais: o Sistema Nervoso Alterado e o Harmonia Enlouquece. As conclusões indicam que a emergência de tais grupos musicais está associada ao cenário da Reforma Psiquiátrica e que as suas práticas podem problematizar e contrariar o estigma da loucura.

  17. Rio de Janeiro: Instrumentation school

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Students from Latin America were able to get hands-on experience in state-of-the-art physics instrumentation in this year's School on Instrumentation for High Energy Physics organized by the active Instrumentation Panel of ICFA (the International Committee for Future Accelerators) at the Centro Brasileiro de Pesquicas Fisicas (CBPF), Rio de Janeiro, in July

  18. In-situ Moessbauer Spectroscopy with MIMOS II at Rio Tinto, Spain

    Energy Technology Data Exchange (ETDEWEB)

    Fleischer, I; Klingelhoefer, G; Wehrheim, S; Ebert, S; Panthoefer, M; Blumers, M; Schmanke, D; Maul, J; Schroeder, C [Institut fuer Anorganische und analytische Chemie, Johannes-Gutenberg-Universitaet Mainz, Staudinger Weg 9, 55128 Mainz (Germany); Rull, F, E-mail: fleischi@uni-mainz.d [Unidad Asociada UVA-CSIC, al Centro de AstrobiologIa, Universidad de Valladolid, 47006-Valladolid (Spain)

    2010-03-01

    The Rio Tinto, located in southwest Spain, exhibits a nearly constant, acidic pH-value along its course. Due to the formation of sulfate minerals, Rio Tinto is considered a potential analogue site for sulfate-rich regions on Mars, in particular at the landing site of the Mars Exploration Rover Opportunity, where the ferric sulfate mineral jarosite was identified with Opportunity's Moessbauer spectrometer. Primary and secondary mineralogy was investigated in situ with portable Raman and Moessbauer spectrometers at four different Rio Tinto sampling sites. The two techniques analyse different sample portions due to their specific field of view and sampling depth and provide complementary mineralogical information.

  19. In-situ Moessbauer Spectroscopy with MIMOS II at Rio Tinto, Spain

    International Nuclear Information System (INIS)

    Fleischer, I; Klingelhoefer, G; Wehrheim, S; Ebert, S; Panthoefer, M; Blumers, M; Schmanke, D; Maul, J; Schroeder, C; Rull, F

    2010-01-01

    The Rio Tinto, located in southwest Spain, exhibits a nearly constant, acidic pH-value along its course. Due to the formation of sulfate minerals, Rio Tinto is considered a potential analogue site for sulfate-rich regions on Mars, in particular at the landing site of the Mars Exploration Rover Opportunity, where the ferric sulfate mineral jarosite was identified with Opportunity's Moessbauer spectrometer. Primary and secondary mineralogy was investigated in situ with portable Raman and Moessbauer spectrometers at four different Rio Tinto sampling sites. The two techniques analyse different sample portions due to their specific field of view and sampling depth and provide complementary mineralogical information.

  20. Innovation politics post-Rio+20: hybrid pathways to sustainability?

    OpenAIRE

    Adrian Ely; Adrian Smith; Andy Stirling; Melissa Leach; Ian Scoones

    2013-01-01

    The ability of innovation—both technical and social—to stretch and redefine ‘limits to growth’ was recognised at Stockholm in 1972, and has been a key feature in debates through to Rio+20 in 2012. Compared with previous major moments of global reflection about human and planetary futures—Stockholm, Rio in 1992, Johannesburg in 2002—we now have a better understanding of how innovation interacts with social, technological, and ecological systems to contribute to transitions at multiple levels. ...

  1. Biomonitoramento indica poluição do Rio Guandu por compostos cancerígenos

    Directory of Open Access Journals (Sweden)

    Mayra Mansur Reimann

    2013-12-01

    Full Text Available O rio Guandu é responsável pelo fornecimento de água potável para mais de 10 milhões de pessoas da região metropolitana do Rio de Janeiro. Entretanto, diversos estudos têm demonstrado que esse rio apresenta elevados níveis de contaminação por substâncias que podem causar mutações e câncer. Portanto, é de extrema importância que providências sejam tomadas para melhorar a qualidade da água dessa bacia hidrográfica. O objetivo deste estudo foi avaliar o potencial do uso da enzima etoxiresorufina O-desetilase (EROD hepática de tilápias (Oreochromis niloticus como biomarcadora no monitoramento da qualidade da água do rio Guandu. A atividade da enzima foi determinada através de fluorimetria em frações microssomais e pós-mitocondriais de tilápias capturadas no rio Guandu e em dois sítios controles. Nossos resultados mostraram que a EROD hepática de tilápias capturadas no rio Guandu apresentou atividade 700% maior do que daquelas capturadas nos sítios controles. Esta elevada atividade da EROD nos fígados das tilápias do rio Guandu indica grande indução da subfamília de CYP1A. Diversos autores têm demonstrado que a indução desta isoforma de citocromo P-450 está associada à presença dos contaminantes bifenilas policloradas (PCB  e dioxinas, que apresentam atividade cancerígena. Frente a estes resultados, não recomendamos o consumo de peixes capturados no rio Guandu, e sugerimos que outras pesquisas sejam feitas para que a origem destes contaminantes ambientais seja esclarecida.   Palavras-chave: Citocromo P-450, Monitoramento, Poluição, Rio Guandu, Tilapia.

  2. Histoplasmose pulmonar aguda no Rio Grande do Sul Acute pulmonary histoplasmosis in the State of Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Gisela Unis

    2005-02-01

    Full Text Available INTRODUÇÃO: A histoplasmose pulmonar aguda depende da inalação de uma grande quantidade de propágulos fúngicos por um paciente hígido. O tempo de exposição determina a gravidade da doença. Uma epidemia é influenciada por fatores que afetam o crescimento e a transmissão do Histoplasma capsulatum var. capsulatum na natureza. OBJETIVO: Identificar os aspectos epidemiológicos e clínico-laboratoriais dos pacientes com histoplasmose pulmonar aguda no Rio Grande do Sul e compará-los com as microepidemias relatadas no Brasil. MÉTODO: Foram revisados 212 prontuários clínicos de pacientes com histoplasmose dos arquivos do Laboratório de Micologia do Complexo Hospitalar Santa Casa de Porto Alegre (RS num período de 25 anos (1977-2002. Foram identificados e incluídos no estudo os casos de histoplasmose pulmonar aguda com cultivo positivo e/ou achado histopatológico compatível. As microepidemias foram diagnosticadas com a comprovação de um caso ou evidência soromicológica com história clínica compatível. Foram revisadas as microepidemias publicadas no Brasil. RESULTADOS: Dezoito de um total de 212 pacientes (8,5% foram incluídos no trabalho. A idade variou de 8 a 63 anos (média de 35,4; mediana de 34,5, e 67% eram do sexo masculino. A história epidemiológica foi sugestiva em 11 pacientes (61%. O tipo primário de histoplasmose pulmonar aguda foi o mais freqüente (17; 95%. Houve predomínio de casos isolados. CONCLUSÃO: O reconhecimento de casos isolados e a presença de microepidemias demonstram a abundância do H. capsulatum no solo, e juntamente com a ocorrência de todas as formas da doença, confirmam o Rio Grande do Sul como hiperendêmico para histoplasmose.BACKGROUND: Acute pulmonary histoplasmosis is a respiratory infection occurring when an otherwise healthy individual inhales a large quantity of fungal propagules. Length of exposure determines disease severity. An epidemic is influenced by factors affecting the

  3. Education for Sustainable Development at the United Nations Conference on Sustainable Development (Rio+20)

    Science.gov (United States)

    Journal of Education for Sustainable Development, 2012

    2012-01-01

    The United Nations Conference on Sustainable Development (Rio+20) was held in Rio de Janeiro, Brazil, 20-22 June 2012, marking the twentieth anniversary of the United Nations Conference on Sustainable Development in Rio de Janeiro in 1992 and the tenth anniversary of the 2002 World Summit on Sustainable Development in Johannesburg. With more than…

  4. Prevalência de sintomáticos respiratórios e tuberculose ativa.

    Directory of Open Access Journals (Sweden)

    Catiane Correa Pereira

    2013-07-01

    Full Text Available Objetivo: Estimar a prevalência de sintomáticos respiratórios e tuberculose ativa em uma população privada de liberdade no Rio Grande do Sul, Brasil. Métodos: Estudo epidemiológico descritivo no Presídio Regional de Santa Cruz do Sul, a partir de triagem realizada para identificação de sintomáticos respiratórios (SR utilizando instrumento recomendado pela OMS. Após a identificação dos sintomáticos respiratórios, foi realizada entrevista e coleta de amostras biológicas para realização de sorologia para HIV, baciloscopia, cultura e teste de susceptibilidade do Mycobacterium tuberculosis frente aos antibióticos para. Resultados: Um total de 70 indivíduos (20,6% foram considerados sintomáticos respiratórios. Entre os sintomáticos respiratórios, a prevalência de tuberculose e HIV na população estudada foi de 1,9% e 4,48%, respectivamente. Conclusão: Medidas de prevenção devem ser adotadas como forma de conter a transmissão da tuberculose no presídio e de prevenir o contágio na comunidade carcerária, bem como de familiares. A cooperação entre o sistema prisional e departamentos locais de saúde é necessária para melhorar a realização de diagnósticos e acompanhamento de pacientes.

  5. Lógicas para la red

    Directory of Open Access Journals (Sweden)

    Antonia HUERTAS

    2009-09-01

    Full Text Available RESUMEN: Tim Berners-Lee y sus colegas del World Wide Web Consortium (W3C llamaron «Semantic Web» al que sería el siguiente estadio de desarrollo de la red (inevitablemente traducido al castellano como Web Semántica. La idea detrás de esta evolución de la red es extender con metadatos y reglas lógicas la red basada en el lenguaje html, con el objetivo de que la infraestructura resultante permita a las máquinas entender los datos de la red de la misma forma que los entendemos los humanos. Así, añadir lógica a la red permitiría a los ordenadores tomar decisiones, hacer inferencias y responder preguntas. En este texto se pretende revisar las lógicas que han sido propuestas para permitir esta nueva web inteligente y repasar las cuestiones teóricas y pragmáticas más importantes de la corta pero intensa historia de las lógicas para la red.ABSTRACT: Tim Berners-Lee and their colleagues of the World Wide Web Consortium (W3C called «Semantic Web» the next development of the Web. The idea behind this evolution of the Web is to extend the present network based on the HTML language with metadata and logical rules, with the aim of the resulting infrastructure allowing machines to understand Web data in the same way that human beings understand them. Thus, adding logic to the Web would allow the computers to take decisions, to do inferences and to answer questions. In this paper it is intended to revise the logics that have been suggested to allow this new intelligent Web and to revise the most important theoretical and pragmatic questions of the short but intense history of logics for the Web.

  6. Synthesis of national reports for Rio+20

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-01-15

    In the lead up to the United Nations Conference on Sustainable Development (Rio+20), which took place in Brazil in June 2012, there were numerous efforts in countries around the world to help governments, civil society organizations and individuals prepare for the event. One of the more significant efforts led by UNDP in collaboration with the United Nations Department of Economic and Social Affairs (UN DESA) was a support programme to 72 countries across all regions to build a consensus on national views around the themes and objectives of the Rio+20 Conference. This report highlights significant advances in sustainable development from almost 60 country reports and underscores the challenges and bottlenecks to moving beyond the economic-led growth strategies of the past 20 years.

  7. Don't Take This with That!

    Medline Plus

    Full Text Available ... of problems. How it does or doesn’t work Depending on the active ingredient, grapefruit can reduce ... follow these tips: Ask your pharmacist or other health care professional if you can have fresh grapefruit ...

  8. Don't Take This with That!

    Medline Plus

    Full Text Available ... tips: Ask your pharmacist or other health care professional if you can have fresh grapefruit or grapefruit ... Inspections & Compliance Federal, State & Local Officials Consumers Health Professionals Science & Research Industry Scroll back to top Popular ...

  9. Don't Take This with That!

    Medline Plus

    Full Text Available ... Food and Drug Administration that can have negative interactions with grapefruit. As little as one cup of ... medicine interacts with grapefruit juice. Related Information Drug Interactions: What You Should Know More in Special Features ...

  10. Don't Take This with That!

    Medline Plus

    Full Text Available ... of problems. How it does or doesn’t work Depending on the active ingredient, grapefruit can reduce ... may be on the way Scientists are currently working on breeding hybrid grapefruits that will be safe ...

  11. A FALTA DE SANEAMENTO E O IMPACTO AMBIENTAL EM RIOS URBANOS

    Directory of Open Access Journals (Sweden)

    Leandro Souza de Freitas

    2017-01-01

    Full Text Available O impacto ambiental em rios traz uma preocupação com a falta d’água nos dias atuais. O rio base deste estudo é o rio Pilar localizado na Baixada Fluminense no estado do Rio de Janeiro. É cada vez maior a importância, nos dias atuais, de se buscar o uso racional da água, consciência essa já comumente disseminada no meio empresarial e entre a população, fato evidenciado pela crise hídrica vivida recentemente pela região sudeste (2014-2015. Ainda que rios, lagos e córregos abasteçam regiões inteiras e desempenhem um papel fundamental na vida de todos. A preservação dos cursos d'água no Brasil está longe de ser a ideal, embora disponham de avançado arcabouço legislativo, como por exemplo, a lei nº 9.433, de 1997. A poluição hídrica de maior representatividade em volume e carga é de natureza orgânica, principalmente por estar associada à composição dos esgotos domésticos. Este problema já está contornado em países mais desenvolvidos, mas ainda constitui o principal impacto de qualidade ambiental no Brasil.

  12. A construção do hipertexto em dicionários escolares infantis

    Directory of Open Access Journals (Sweden)

    Rodrigo Alves Silva

    2017-07-01

    Full Text Available Este trabalho analisou a hipertextualidade em dicionários escolares infantis avaliados pelo PNLD. Para tanto, observou-se, na construção do hipertexto, os elementos multimodais, principalmente os boxes que contêm outros gêneros textuais. Este trabalho partiu do pressuposto de que o hipertexto está também presente no texto impresso e não é exclusivo do texto virtual, baseado em Koch (2009 e Coscarelli (2009. Além disso, utilizou-se dos conceitos de multimodalidade para a análise das páginas dos dicionários. O corpus de análise é composto por dois dicionários escolares: Saraiva Júnior: dicionário da língua portuguesa ilustrado (2009 e Saraiva infantil de A a Z: dicionário da língua portuguesa ilustrado (2012. Uma análise prévia permitiu concluir que esses dicionários possuem recursos multimodais (como imagens, boxes com poemas, adivinhações etc. que ajudam a tornar esses materiais objetos hipertextuais, pois as informações não ficam apenas a cargo dos verbetes, mas também estão presentes nos demais elementos que os circundam.

  13. A pedagogia do Rosário, conteúdo educativo da festa: estudo do potencial pedagógico contido na festa de Nossa Senhora do Rosário

    OpenAIRE

    Maria das Merces Bonfim Ambrosio

    1989-01-01

    Elaborado como dissertação de Mestrado em educação, "A Pedagogia do Rosário-caráter educativo da Festa", objetivou desvendar os conteúdos educativos presentes na Festa de Nossa Senhora do Rosário, em Sete Lagoas-MG. Através da participação nesses eventos, nos anos de 1981 e 1982 e de entrevistas com membros das guardas de Nossa Senhora do rosário naquela cidade- além de leitura orientada-foi possível traçar as linhas dessa pedagogia, presentes neste trabalho. Trata-se de uma manifestação cult...

  14. O tratado sobre a luz de Huygens: comentários

    Directory of Open Access Journals (Sweden)

    Sonia Krapas

    2011-01-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2011v28n1p123 Huygens é conhecido no ensino introdutório de Física por dar conta da refração segundo um modelo ondulatório. Livros didáticos lhe rendem homenagens atribuindo seu nome a um princípio, mas em sua obra máxima, Tratado sobre a luz, é possível se ver muito mais: sua inventividade na defesa de um modelo ondulatório para a luz como alternativo ao modelo corpuscular. Neste trabalho, tenta-se evidenciar o raciocínio de Huygens, mostrando que, apesar de ter sido publicada há mais de trezentos anos, a obra está escrita numa linguagem relativamente acessível.

  15. The city and its souvenirs: Rio de Janeiro for tourists to have

    Directory of Open Access Journals (Sweden)

    Bianca Freire-Medeiros

    2007-09-01

    Full Text Available This article examines some aspects of the tourist representation of Rio de Janeiro having the souvenirs as support. It reflects upon the tourist image of the city as it appears in the objects considered to be typically for tourists by proposing a folded movement: to the material collected in four stores in Rio de Janeiro, it opposes souvenirs with different cultural backgrounds. It aims at interpreting the place occupied by souvenirs in the broader setting of representations and cultural products that establish Rio as a tourist destination.

  16. Associations between red meat and risks for colon and rectal cancer depend on the type of red meat consumed.

    Science.gov (United States)

    Egeberg, Rikke; Olsen, Anja; Christensen, Jane; Halkjær, Jytte; Jakobsen, Marianne Uhre; Overvad, Kim; Tjønneland, Anne

    2013-04-01

    Cancer prevention guidelines recommend limiting intake of red meat and avoiding processed meat; however, few studies have been conducted on the effects of specific red meat subtypes on colon cancer or rectal cancer risk. The study aim was to evaluate associations between intake of red meat and its subtypes, processed meat, fish, and poultry and risk for colon cancer or rectal cancer in the Danish Diet, Cancer and Health cohort study. We also evaluated whether fish or poultry should replace red meat intake to prevent colon cancer or rectal cancer. During follow-up (13.4 y), 644 cases of colon cancer and 345 cases of rectal cancer occurred among 53,988 participants. Cox proportional hazards models were used to compute incidence rate ratio (IRRs) and 95% CIs. No associations were found between intake of red meat, processed meat, fish, or poultry and risk for colon cancer or rectal cancer. The risk associated with specific red meat subtypes depended on the animal of origin and cancer subsite; thus, the risk for colon cancer was significantly elevated for higher intake of lamb [IRR(per 5g/d) = 1.07 (95% CI: 1.02-1.13)], whereas the risk for rectal cancer was elevated for higher intake of pork [IRR(per 25g/d) = 1.18 (95% CI: 1.02-1.36)]. Substitution of fish for red meat was associated with a significantly lower risk for colon cancer [IRR(per 25g/d) = 0.89 (95% CI: 0.80-0.99)] but not rectal cancer. Substitution of poultry for red meat did not reduce either risk. This study suggests that the risks for colon cancer and potentially for rectal cancer differ according to the specific red meat subtype consumed.

  17. Albuquerque/Middle Rio Grande Urban Waters Viewer

    Data.gov (United States)

    U.S. Environmental Protection Agency — These data have been compiled in support of the Middle Rio Grande/Albuquerque Urban Waters Partnership for the region including Albuquerque, New Mexico.The Middle...

  18. Regulation of Picea abies seed dormancy by red and far-red light at various moisture contents

    Energy Technology Data Exchange (ETDEWEB)

    Leinonen, K.; Chantal, M. de [Helsinki Univ. (Finland). Dept. of Forest Ecology

    1998-04-01

    The effects of red (R), far-red (FR) and R+FR light on Norway spruce seed dormancy were studied at five different moisture contents (MC) between 5 and 20%. The degree of dormancy was studied by germinating seeds over a wide range of temperatures in the dark. The non-irradiated control seeds were shallowly dormant, only a proportion of them germinated and within a limited temperature range. Red light progressively stimulated germination between 5 and 17% MC, but this effect was reversed if a FR treatment followed, although all germination could not be inhibited by one FR pulse. Far-red light had a slightly stimulating effect at 19% MC. To generate seeds able to germinate over a wide range of temperatures in darkness, an artificial light pretreatment should be given to seeds at MC above 17% in order to receive maximum response 24 refs, 2 figs, 1 tab

  19. Past, Present and Future of General Chemistry in the PUC-Rio.

    Science.gov (United States)

    Farias, Percio A. M.; Goulart, Mauricio S.; de Mello, Paulo Correa

    This manuscript describes the role of chemistry as a vehicle for understanding many other basic sciences and engineering based on the experience acquired in the General Chemistry course at the "Center Technical-Scientific" at the Pontific Catholic University of Rio de Janeiro (CTC-PUC-Rio). A description of the history of the General…

  20. Don't Take This with That!

    Medline Plus

    Full Text Available ... and tangelos (a cross between tangerines and grapefruit) affect the same enzyme as grapefruit juice, so avoid ... feeds Follow FDA on Twitter Follow FDA on Facebook View FDA videos on YouTube View FDA photos ...

  1. Don't Take This with That!

    Medline Plus

    Full Text Available ... are currently working on breeding hybrid grapefruits that will be safe to mix with medications. In the ... If it’s OK to have grapefruit juice, there will be no mention of it in the guide ...

  2. Effect of Red Pepper (Capsicum frutescens) Powder or Red Pepper Pigment on the Performance and Egg Yolk Color of Laying Hens.

    Science.gov (United States)

    Li, Huaqiang; Jin, Liji; Wu, Feifei; Thacker, Philip; Li, Xiaoyu; You, Jiansong; Wang, Xiaoyan; Liu, Sizhao; Li, Shuying; Xu, Yongping

    2012-11-01

    Two experiments were conducted to study the effects of red pepper (Capsicum frutescens) powder or red pepper pigment on the performance and egg yolk color of laying hens. In Exp. 1, 210, thirty-wk old, Hy-line Brown laying hens were fed one of seven diets containing 0.3, 0.6, 1.2, 2.0, 4.8 or 9.6 ppm red pepper pigment or 0.3 ppm carophyll red. Each diet was fed to three replicate batteries of hens with each battery consisting of a row of five cages of hens with two hens per cage (n = 3). In Exp. 2, 180, thirty-wk old, Hyline Brown laying hens, housed similarly to those in Exp. 1, were fed an unsupplemented basal diet as well as treatments in which the basal diet was supplemented with 0.8% red pepper powder processed in a laboratory blender to an average particle size of 300 μm, 0.8% red pepper powder processed as a super fine powder with a vibrational mill (44 μm) and finally 0.8% red pepper powder processed as a super fine powder with a vibrational mill but mixed with 5% Na2CO3 either before or after grinding. A diet supplemented with 0.3 ppm carophyll red pigment was also included (n = 3). In both experiments, hens were fed the red pepper powder or pigment for 14 days. After feeding of the powder or pigment was terminated, all hens were fed the basal diet for eight more days to determine if the dietary treatments had any residual effects. In Exp. 1, there were no differences in egg-laying performance, feed consumption or feed conversion ratio due to inclusion of red pepper pigment in the diet. Average egg weight was higher (pfeeding red pepper powder did not affect egg-laying performance, feed consumption or feed conversion ratio (p>0.05). However, compared with the control group, supplementation with all of the red pepper powder treatments increased egg weight (pfeed additives for improving egg yolk color for laying hens.

  3. Antimicrobial and Anti-biofilm Activities of Betacyanin Fractions from Red Pitahaya (Hylocereus polyrhizus) and Red Spinach (Amaranthus dubius)

    OpenAIRE

    YI YI YONG

    2018-01-01

    This thesis examines the ability of betacyanin, a natural red-violet pigment from red pitahaya (Hylocereus polyrhizus) and red spinach (Amaranthus dubius)in inhibiting the growth of bacteria that cause diseases and bacteria attached to surfaces such as glass, polystyrene, polyvinyl chloride, polyethylene, polypropylene, and silicone rubber. Extraction was optimized to produce a betacyanin fraction and various assays were carried out to identify the best betacyanin formulation against a polymi...

  4. Diospyros lotus leaf and grapefruit stem extract synergistically ameliorate atopic dermatitis-like skin lesion in mice by suppressing infiltration of mast cells in skin lesions.

    Science.gov (United States)

    Cho, Byoung Ok; Che, Denis Nchang; Yin, Hong Hua; Shin, Jae Young; Jang, Seon Il

    2017-05-01

    Atopic dermatitis, a chronic relapsing and pruritic inflammation of the skin also thought to be involved in, or caused by immune system destruction is an upsetting health problem due to its continuously increasing incidence especially in developed countries. Mast cell infiltration in atopic dermatitis skin lesions and its IgE-mediated activation releases various cytokines and chemokines that have been implicated in the pathogenesis of atopic dermatitis. This study was aimed at investigating synergistic anti-inflammatory, anti-pruritic and anti-atopic dermatitis effects of Diospyros lotus leaf extract (DLE) and Muscat bailey A grapefruit stem extract (GFSE) in atopic dermatitis-like induced skin lesions in mice. Combinations of DLE and GFSE inhibited TNF-α and IL-6 production more than DLE or GFSE in PMA plus calcium ionophore A23187-activated HMC-1 cells. DLE and GFSE synergistically inhibited compound 48/80-induced dermal infiltration of mast cells and reduced scratching behavior than DLE or GFSE. Furthermore, DLE and GFSE synergistically showed a stronger ameliorative effect in skin lesions by reducing clinical scores; dermal infiltration of mast cells; ear and dorsal skin thickness; serum IgE and IL-4 production in atopic dermatitis-like mice. Collectively, these results suggest that DLE and GFSE synergistically exhibit anti-atopic dermatitis effects in atopic dermatitis-like skin lesions in mice. Copyright © 2017. Published by Elsevier Masson SAS.

  5. Os tempos da enunciação e dos enunciados publicitários e a questão do cronotopo publicitário

    Directory of Open Access Journals (Sweden)

    Eneus Trindade

    2008-09-01

    Full Text Available Este texto refere-se a uma teoria da enunciação publicitária. O objetivo principal é apresentar as nossas reflexões sobre os efeitos temporais nos discursos publicitários. Assim, são considerados os efeitos temporais da enunciação e dos enunciados publicitários. Nossa reflexão discute também a questão da fusão do tempo ao espaço no discurso da publicidade, apresentando o conceito de cronotopo publicitário. Palavras-chave: Enunciação; publicidade; processos midiáticos e culturais; tempo. ABSTRACT This text refers to theory of enunciation process in advertising. The main aim is to present our reflections about time effects in advertising discourses. We considered the time effects of enunciation and advertising messengers announced. Our reflection aims to discuss too relations between space and time in advertising discourse presenting the concept of advertising cronotopo. Keywords: Enunciation; advertising; midiatic and cultural process; time.

  6. Agreement between Los Rios Community College District and Los Rios College Federation of Teachers (Local 2279, American Federation of Teachers, AFL-CIO), July 1, 1987-June 30, 1990.

    Science.gov (United States)

    Los Rios Community Coll. District, Sacramento, CA.

    The collective bargaining agreement between the Los Rios Community College District Board of Trustees and the Los Rios College Federation of Teachers/California Teachers Association/National Education Association is presented. This contract, covering faculty at American River College, Cosumnes River College, and Sacramento City College, applies to…

  7. Don't Take This with That!

    Medline Plus

    Full Text Available ... Administration that can have negative interactions with grapefruit. As little as one cup of juice or two grapefruit wedges ... delay, decrease, or enhance absorption of certain drugs; as a result, the patient does not receive the ...

  8. Comparative metagenomics of the Red Sea

    KAUST Repository

    Mineta, Katsuhiko

    2016-01-26

    Metagenome produces a tremendous amount of data that comes from the organisms living in the environments. This big data enables us to examine not only microbial genes but also the community structure, interaction and adaptation mechanisms at the specific location and condition. The Red Sea has several unique characteristics such as high salinity, high temperature and low nutrition. These features must contribute to form the unique microbial community during the evolutionary process. Since 2014, we started monthly samplings of the metagenomes in the Red Sea under KAUST-CCF project. In collaboration with Kitasato University, we also collected the metagenome data from the ocean in Japan, which shows contrasting features to the Red Sea. Therefore, the comparative metagenomics of those data provides a comprehensive view of the Red Sea microbes, leading to identify key microbes, genes and networks related to those environmental differences.

  9. Diferenças entre fatores de risco para infecção pelo HIV em usuários de drogas injetáveis do Rio de Janeiro e Porto Alegre Risks differences of HIV infection between injection drug users in Rio de Janeiro and Porto Alegre

    Directory of Open Access Journals (Sweden)

    Raquel De Boni

    2005-01-01

    Full Text Available INTRODUÇÃO: No Brasil, aproximadamente 19 mil pessoas adquiriram o vírus HIV por meio do uso de drogas injetáveis desde o início da epidemia, com a soroprevalência em amostras destes usuários variando entre 25% e 65%. O objetivo deste estudo é comparar os comportamentos de risco para infecção por HIV entre amostras de usuários de cocaína injetável do Rio de Janeiro e de Porto Alegre. MÉTODOS: Comparação entre dados de estudos transversais conduzidos em Porto Alegre e no Rio de Janeiro. Um grupo de 250 indivíduos que haviam utilizado cocaína injetável nos seis meses prévios à coleta respondeu ao RBA (Risk Behaviour Assessement e realizou testagem anti-HIV em ambos os centros. RESULTADOS: Não houve diferença estatisticamente significativa entre os dados demográficos, exceto entre as médias de idade (31 anos no Rio de Janeiro e 28 anos em Porto Alegre. Em Porto Alegre, houve maior uso de cocaína injetável e maior número de comportamentos de risco relacionados a este uso. No Rio de Janeiro, houve mais comportamentos sexuais de risco e uso mais freqüente de cocaína aspirada e álcool. DISCUSSÃO: Os usuários de cocaína injetável das duas regiões estudadas apresentavam freqüências diferentes nos comportamentos de risco para HIV, e estes comportamentos parecem estar relacionados com o tipo, a via e a freqüência das drogas utilizadas. Os dados foram coletados entre 1994 e 1997, quando o uso de crack era menor nestas cidades, o que pode ter alterado o padrão atual de comportamentos de risco para HIV em usuários de cocaína.INTRODUCTION: In Brazil, about 19.000 of HIV cases have been attributed to injection drug use, with the seroprevalence among such samples ranging from 25% to 65%. The aim of this study is to compare drug using and HIV risk behaviors among injection cocaine users in Rio de Janeiro and Porto Alegre. METHODS: Comparative analysis of cross-sectional data from two studies conducted in Porto Alegre and

  10. Far red bioluminescence from two deep-sea fishes.

    Science.gov (United States)

    Widder, E A; Latz, M I; Herring, P J; Case, J F

    1984-08-03

    Spectral measurements of red bioluminescence were obtained from the deep-sea stomiatoid fishes Aristostomias scintillans (Gilbert) and Malacosteus niger (Ayres). Red luminescence from suborbital light organs extends to the near infrared, with peak emission at approximately 705 nanometers in the far red. These fishes also have postorbital light organs that emit blue luminescence with maxima between 470 and 480 nanometers. The red bioluminescence may be due to an energy transfer system and wavelength-selective filtering.

  11. Quando o imaginário se diz educacional

    OpenAIRE

    Araújo, Alberto Filipe

    2010-01-01

    O imaginário educacional é devedor da concepção romântica de educação que privilegia a formação da interioridade do sujeito (daquilo que Jung denomina de das Selbst : o si-mesmo) por meio de uma viagem iniciática sob a forma, por exemplo, do "romance de formação". Daí a necessidade de se estruturar, mediante uma hermenêutica adequada, aquilo que constitui a sustância do imaginário educacional (alegorias, metáforas, símbolos, ideologemas e mitos), ainda que este apareça de um modo geral degrad...

  12. Guidebook to Rio Grande rift in New Mexico

    Science.gov (United States)

    Hawley, J.W.

    1978-01-01

    Discusses the details of geologic features along the rift zone. Included are short papers on topics relative to the overall region. These papers and the road logs are of special interest to any one pursuing further study of the rift. This book is a comprehensive guide to the middle and late Cenozoic geology of the Rio Grande region of Colorado and New Mexico. Though initially used on field trips for the International Symposium on Tectonics and Magmatism of the Rio Grande rift, the guidebook will be useful to anyone interested in the Cenozoic history of the 600-mi-long area extending from central Colorado to El Paso, Texas.

  13. ESTILOS FLUVIAIS E EVIDÊNCIAS DE MUDANÇAS AMBIENTAIS NA PLANÍCIE DO RIO MIRANDA, PANTANAL

    Directory of Open Access Journals (Sweden)

    Eder Renato Merino

    2013-03-01

    Full Text Available O rio Miranda é um importante afluente do rio Paraguai e tem grande parte de seu curso na planície do Pantanal. O rio tem sinuosidade média a alta, sendo do tipo meandrante na maior parte do seu percurso em domínio aluvial. Com base nos padrões do canal e da planície, três segmentos fluviais com diferentes estilos foram caracterizados e descritos. Ainda nos domínios do planalto, o rio forma um cinturão de meandros numa planície agradacional, que está confinada em vale no embasamento cristalino. O rio deixa de correr num cinturão de meandros ao adentrar no Pantanal, para formar um cordão composto por canal e diques marginais que se destaca pela elevação mais alta em relação à planície agradacional, que se torna mais larga ao deixar o vale confinado. Paleocinturões de meandros e grandes meandros abandonados com dimensões superiores às dos canais atuais, existentes nas planícies agradacionais, permitem interpretar importantes mudanças ambientais e paleohidrológicas ocorridas a partir do Pleistoceno tardio. No seu baixo curso o rio volta a correr num cinturão de meandros, porem inciso em depósitos aluviais mais antigos, o que denuncia a natureza degradacional da planície distal do rio. Esta planície é palco da ação erosiva de fluxos de águas em lençol durante as inundações e de incisão por rede de pequenos canais tributários que drenam a planície depois das cheias. A avulsão ocorrida na altura do Morro do Azeite desempenhou importante papel na configuração do traçado do canal atual do rio Miranda, deslocando em 20 km para norte sua foz no rio Paraguai.  Palavras Chave – Rio Miranda, Pantanal, rio meandrante

  14. Palmeiras (Arecaceae das restingas do Estado do Rio de Janeiro, Brasil Palms (Arecaceae from the restingas of Rio de Janeiro State, Brazil

    Directory of Open Access Journals (Sweden)

    Ricardo Carneiro da Cunha Reis

    2006-09-01

    Full Text Available Neste trabalho foram coletadas, identificadas e sistematizadas as palmeiras das restingas do estado do Rio de Janeiro. Para a coleta de material, foram eleitas cinco estações de coleta consideradas representativas em termos de ocorrência de palmeiras. Foram identificadas 11 espécies, as quais podem ser reconhecidas pelo uso da chave dicotômica fornecida, e confirmadas pelas descrições e fotos apresentadas. O tratamento taxonômico das espécies encontra-se complementado por informações de distribuição geográfica, ecologia, nomes vulgares, e listas dos espécimes de herbário examinados.Palms of the restingas of Rio de Janeiro State were collected, identified and treated taxonomically. The plants were collected at five sites that are representative in terms of palm species occurrence. The 11 species can be identified using the dichotomous key and confirmed using descriptions and photos. The taxonomic treatment is accompanied by additional information on geographic distribution, ecology, common names, and lists of herbarium specimens examined.

  15. RED ONE kuvaajan työkaluna

    OpenAIRE

    Käki, Ossi

    2010-01-01

    Opinnäytetyöni projektiosa, 30-minuuttinen lyhytelokuva Huomisen Muisto – Memory of Tomorrow kuvattiin RED ONE -kameralla vuosina 2008-2009. Opinnäytetyöni kirjallinen osuus tutkii miten RED ONE soveltuu kuvaajan työvälineeksi lyhytelokuvassa. Huomisen Muisto oli ensimmäinen Tampereen ammattikorkeakoulussa RED ONE:lla kuvattu elokuva ja koko tekninen workflow piti kehittää lähes nollasta. Paljon kuvan digitaalista jälkikäsittelyä sisältävänä science fiction -elokuvana Huomisen Muisto asetti i...

  16. A influência da marca Coca Cola na atratividade e manutenção dos funcionários em uma afiliada no Rio Grande Do Sul

    Directory of Open Access Journals (Sweden)

    Christine da Silva Schröeder

    2014-05-01

    Full Text Available O estudo analisou a influência da marca Coca-Cola na atratividade e manutenção de funcionários em uma empresa afiliada de uma franqueada da The Coca-Cola Company, denominada CVI Refrigerantes Ltda., identificando o nível de conhecimento prévio dos colaboradores da empresa sobre a mesma, verificando os atributos relacionados à marca na visão destes e diagnosticando fatores considerados decisivos no momento da escolha da empresa como empregadora. Foi realizada análise documental e de entrevistas semiestruturadas com funcionários. Constata-se que a imagem e o nome da marca Coca-Cola constituem, para os funcionários, fortes atrativos, além dos benefícios e oportunidades de crescimento oferecidos.

  17. Comparative metagenomics of the Red Sea

    KAUST Repository

    Mineta, Katsuhiko

    2016-01-01

    started monthly samplings of the metagenomes in the Red Sea under KAUST-CCF project. In collaboration with Kitasato University, we also collected the metagenome data from the ocean in Japan, which shows contrasting features to the Red Sea. Therefore

  18. Red Emitting Phenyl-Polysiloxane Based Scintillators for Neutron Detection

    International Nuclear Information System (INIS)

    Dalla Palma, Matteo; Quaranta, Alberto; Marchi, Tommaso; Gramegna, Fabiana; Cinausero, Marco; Carturan, Sara; Collazuol, Gianmaria

    2013-06-01

    In this work, the performances of new red emitting phenyl- substituted polysiloxane based scintillators are described. Three dyes were dispersed in a phenyl-polysiloxane matrix in order to shift the scintillation wavelength towards the red part of the visible spectrum. PPO, Lumogen Violet (BASF) and Lumogen Red (BASF) were mixed to the starting resins with different wt. % and the analysis of the different samples was performed by means of fluorescence measurements. The scintillation yield to alpha particles at the different dye ratios was monitored by detecting either the full spectrum or the red part of the emitted light. Finally, thin red scintillators with selected compositions were coupled to Avalanche Photodiode sensors, which are usually characterized by higher efficiency in the red part of the spectrum. An increased light output of about 17% has been obtained comparing the red scintillators to standard blue emitting systems. Preliminary results on the detection of fast neutrons with the APD-red scintillator system are also presented. (authors)

  19. Estudo da dieta natural da ictiofauna de um reservatório centenário, São Paulo, Brasil

    Directory of Open Access Journals (Sweden)

    Amanda R. Ribeiro

    2014-12-01

    Full Text Available Este estudo teve como objetivo caracterizar e comparar a alimentação de 13 espécies de peixes em três zonas (zona de influência fluvial, zona de transição e zona lacustre do reservatório de Itupararanga. Foram analisados 436 estômagos, sendo encontrados 17 recursos alimentares, todos de origem autóctone. As dietas predominantes das espécies foram: peixe, inseto, material vegetal e detritos na zona de influência fluvial, peixe, sedimento e material vegetal na zona de transição e inseto, escama e peixe na zona lacustre. Através do Índice Alimentar, as espécies foram categorizadas nas guildas: piscívora, insetívora, detritívora e carcinófaga. O Cluster indicou separação da guilda insetívora em espécies generalistas (insetos diversos e especialista (Chironomidae o que aumenta para cinco guildas. Na zona fluvial foram verificadas quatro guildas; na zona de transição três guildas e na zona lacustre duas guildas. Observou-se ainda uma dominância de espécies piscívoras que pode estar relacionada à idade do reservatório. Este estudo ampliou o conhecimento dos hábitos alimentares dos peixes em reservatórios antigos e suas diferenças, comparando as zonas existentes.

  20. The road from Rio - OPEC's view

    International Nuclear Information System (INIS)

    Subroto

    1994-01-01

    The Secretary General of OPEC presents the views of OPEC on the environmental debate at the Rio Summit, the topic of environmental taxation. Recommendations are put forward on the financing of Agenda 21 programs and on the concept of technology transfer, to help achieve sustainable development

  1. Imaginário, Cultura Global e violência escolar

    Directory of Open Access Journals (Sweden)

    Joyce Mary Adam de Paula e Silva

    2011-06-01

    Full Text Available Neste artigo discutimos a questão da violência escolar à luz do referencial teórico do imaginário. A questão do imaginário a respeito da instituição escolar é analisada face a algumas características da sociedade atual apontadas por diferentes autores tais como Sennett, (2006, Taylor(2006, Baumann ( 2005. São apresentados alguns dados da pesquisa realizada com os professores de duas do interior do Estado de São Paulo, dando-se destaque para o imaginário sobre a escola e as relações que se estabelecem nesse contexto. Esta pesquisa teve como metodologia de coleta de dados a realização de uma dinâmica de grupo. Concluímos chamando a atenção para a importância de que os estudos sobre violência escolar busquem elucidar os diferentes aspectos institucionais focando não somente os alunos e a família dos mesmos, mas as interações que se processam no interior da escola. A análise institucional que enfoque os aspectos micro e macro social pode contribuir para que a escola consiga enfrentar os problemas em uma perspectiva mais realista, buscando caminhos no próprio grupo em interação explicitando barreiras que são interpostas pelo imaginário institucional.

  2. Study of some parameters affecting the in vitro cultivation of Plasmodium falciparum within saimiri sciureus red blood cells

    Directory of Open Access Journals (Sweden)

    T. Fandeur

    1986-06-01

    Full Text Available The in vitro growth and multiplication of the erythrocytic stages of Plasmodium falciparum within Saimiri sciureus (squirrel monkey red blood cells have been studied. Various parameters, such as the origin of the red blood cells and serum supplement, nature of the buffer, influence of the final pH of the medium, role of proteose peptone and glucose addition, were investigated. The selection of the best culture conditions led to the obtention of a reproducible in vitro growth of two parasite cycles in Saimiri erythrocytes, which is an useful achievement for in vitro studies. Our failure to establish a continuous culture line for longer than 19 days, could be explained by a dramatic increasing of osmotic fragility of the Saimiri red blood cells related to their small size.O crescimento e a multiplicação dos estágios eritrocíticos do Plasmodium falciparum in vitro foi estudado em cultivos com hemácias do Saimiri sciureus (macaco de cheiro. Foram investigados vários parâmetros tais como, origem das hemácias e suplementação de soro, tipo de tampão, influência do pH final do meio, papel da proteose-peptona e da glicose adicionados. A seleção das condições ideais de cultivo permitiram, de maneira reprodutível, a obtenção de crescimento do parasita durante dois ciclos nas hemácias do Saimiri. Nosso fracasso em estabelecer uma linhagem contínua de cultivo por mais de 19 dias poderia ser explicado pelo aumento dramático da fragilidade osmótica das hemácias do Saimiri relacionado com seu pequeno tamanho.

  3. Volume tables for red alder.

    Science.gov (United States)

    Floyd A. Johnson; R. M. Kallander; Paul G. Lauterbach

    1949-01-01

    The increasing importance of red alder as a commercial species in the Pacific Northwest has prompted the three agencies listed above to pool their tree measurement data for the construction of standard regional red alder volume tables. The tables included here were based on trees from a variety of sites and form classes. Approximately one quarter of the total number of...

  4. Skeleton decay in red cedar

    Science.gov (United States)

    Kevin T. Smith; Jessie A. Glaeser

    2013-01-01

    Eastern red cedar (Juniperus virginiana) is a common tree species throughout the eastern United States and the Great Plains. Although “cedar” is in the common name, the scientifc name shows a botanical kinship to the juniper species of the American southwest. Red cedar can survive and thrive within a broad range of soil conditions, seasonal...

  5. Social Entrepreneurs in Rio De Janeiro: Learning Experiences and Social Capital

    Science.gov (United States)

    Scheiber, Laura

    2012-01-01

    The purpose of this study is to gain insight into how social entrepreneurs dedicated to violence prevention in Rio de Janeiro learn to take on the role of a social entrepreneur. Based on a two-tiered interview process with 27 social entrepreneurs in Rio de Janeiro conducted over a period of nine months, the study explores the breadth of…

  6. Sedimentation in Rio La Venta Canyon in Netzahualcoyotl Reservoir, Chiapas, Mexico

    Science.gov (United States)

    Juan Antonio de la Fuente; Tom Lisle; Jose Velasquez; Bonnie L. Allison; Alisha Miller

    2000-01-01

    Sedimentation of Rio La Venta as it enters the Netzahualcoyotl Reservoir in Chiapas, Mexico, threatens a unique part of the aquatic ecosystem. Rio La Venta enters the reservoir via a narrow canyon about 16 km long with spectacular, near-vertical limestone bluffs up to 320 m high and inhabited by the flora and fauna of a pristine tropical forest.

  7. DAVs: Red Edge and Outbursts

    Science.gov (United States)

    Luan, Jing

    2018-04-01

    As established by ground based surveys, white dwarfs with hydrogen atmospheres pulsate as they cool across the temperature range, 12500Kred edge is a two-decade old puzzle. Recently, Kepler discovered a number of cool DAVs exhibiting sporadic outbursts separated by days, each lasting several hours, and releasing \\sim 10^{33}-10^{34} {erg}. We provide quantitative explanations for both the red edge and the outbursts. The minimal frequency for overstable modes rises abruptly near the red edge. Although high frequency overstable modes exist below the red edge, their photometric amplitudes are generally too small to be detected by ground based observations. Nevertheless, these overstable parent modes can manifest themselves through nonlinear mode couplings to damped daughter modes which generate limit cycles giving rise to photometric outbursts.

  8. [Mini review] metagenomic studies of the Red Sea

    KAUST Repository

    Behzad, Hayedeh

    2015-10-23

    Metagenomics has significantly advanced the field of marine microbial ecology, revealing the vast diversity of previously unknown microbial life forms in different marine niches. The tremendous amount of data generated has enabled identification of a large number of microbial genes (metagenomes), their community interactions, adaptation mechanisms, and their potential applications in pharmaceutical and biotechnology-based industries. Comparative metagenomics reveals that microbial diversity is a function of the local environment, meaning that unique or unusual environments typically harbor novel microbial species with unique genes and metabolic pathways. The Red Sea has an abundance of unique characteristics; however, its microbiota is one of the least studied amongst marine environments. The Red Sea harbors approximately 25 hot anoxic brine pools, plus a vibrant coral reef ecosystem. Physiochemical studies describe the Red Sea as an oligotrophic environment that contains one of the warmest and saltiest waters in the world with year-round high UV radiations. These characteristics are believed to have shaped the evolution of microbial communities in the Red Sea. Over-representation of genes involved in DNA repair, high-intensity light responses, and osmolyte C1 oxidation were found in the Red Sea metagenomic databases suggesting acquisition of specific environmental adaptation by the Red Sea microbiota. The Red Sea brine pools harbor a diverse range of halophilic and thermophilic bacterial and archaeal communities, which are potential sources of enzymes for pharmaceutical and biotechnology-based application. Understanding the mechanisms of these adaptations and their function within the larger ecosystem could also prove useful in light of predicted global warming scenarios where global ocean temperatures are expected to rise by 1–3 °C in the next few decades. In this review, we provide an overview of the published metagenomic studies that were conducted in the

  9. [Mini review] metagenomic studies of the Red Sea

    KAUST Repository

    Behzad, Hayedeh; Ibarra, Martin Augusto; Mineta, Katsuhiko; Gojobori, Takashi

    2015-01-01

    Metagenomics has significantly advanced the field of marine microbial ecology, revealing the vast diversity of previously unknown microbial life forms in different marine niches. The tremendous amount of data generated has enabled identification of a large number of microbial genes (metagenomes), their community interactions, adaptation mechanisms, and their potential applications in pharmaceutical and biotechnology-based industries. Comparative metagenomics reveals that microbial diversity is a function of the local environment, meaning that unique or unusual environments typically harbor novel microbial species with unique genes and metabolic pathways. The Red Sea has an abundance of unique characteristics; however, its microbiota is one of the least studied amongst marine environments. The Red Sea harbors approximately 25 hot anoxic brine pools, plus a vibrant coral reef ecosystem. Physiochemical studies describe the Red Sea as an oligotrophic environment that contains one of the warmest and saltiest waters in the world with year-round high UV radiations. These characteristics are believed to have shaped the evolution of microbial communities in the Red Sea. Over-representation of genes involved in DNA repair, high-intensity light responses, and osmolyte C1 oxidation were found in the Red Sea metagenomic databases suggesting acquisition of specific environmental adaptation by the Red Sea microbiota. The Red Sea brine pools harbor a diverse range of halophilic and thermophilic bacterial and archaeal communities, which are potential sources of enzymes for pharmaceutical and biotechnology-based application. Understanding the mechanisms of these adaptations and their function within the larger ecosystem could also prove useful in light of predicted global warming scenarios where global ocean temperatures are expected to rise by 1–3 °C in the next few decades. In this review, we provide an overview of the published metagenomic studies that were conducted in the

  10. A concepção de território na Saúde Mental

    Directory of Open Access Journals (Sweden)

    Juarez Pereira Furtado

    2016-10-01

    Full Text Available Resumo: O termo território e seus derivados se tornaram correntes no campo da Saúde Mental desde a reforma psiquiátrica, marco de ideário não hospitalocêntrico e potencialmente emancipatório. No entanto, constatamos em pesquisa empírica anterior que a essa incorporação terminológica não corresponderam concepções e práticas coerentes de reinserção territorial de pessoas com sofrimento mental. Para esclarecer os diversos usos do termo e suas possíveis correlações na prática, realizamos um levantamento sistemático de artigos científicos e documentos oficiais, confrontando-os entre si e com o conceito de território da Geografia Crítica. Concluímos que no campo da Saúde Mental brasileira, à revelia de muitos e sempre renovados esforços críticos, tem prevalecido uma noção funcional de território, que omite relações de poder e apropriações simbólicas, aumentando a tendência de a reinserção de pessoas com sofrimento mental desembocar na sua sujeição ao território dado, em vez de favorecer transformações socioespaciais para o convívio com as diferenças.

  11. Experience Reverses the Red Effect among Chinese Stockbrokers

    OpenAIRE

    Zhang, Tengxiao; Han, Buxin

    2014-01-01

    Recent research has shown that the color red influences psychological functioning. Red is hypothesized to be linked to aggression and danger in evolution, and these links are enhanced by culture-specific uses of red. Thus, color meanings are thought to be grounded in biologically based proclivities and learned associations. However, to date, there has been no direct evidence for the influence of experience on the red effect. This study focused on whether experience could change the psychologi...

  12. Environmental contaminants and biomarker responses in fish from the Rio Grande and its U.S. tributaries: Spatial and temporal trends

    Science.gov (United States)

    Schmitt, C.J.; Hinck, J.E.; Blazer, V.S.; Denslow, N.D.; Dethloff, G.M.; Bartish, T.M.; Coyle, J.J.; Tillitt, D.E.

    2005-01-01

    We collected, examined, and analyzed 368 fish of seven species from 10 sites on rivers of the Rio Grande Basin (RGB) during late 1997 and early 1998 to document temporal and geographic trends in the concentrations of accumulative contaminants and to assess contaminant effects on the fish. Sites were located on the mainstem of the Rio Grande and on the Arroyo Colorado and Pecos River in Texas (TX), New Mexico (NM), and Colorado. Common carp (Cyprinus carpio) and largemouth bass (Micropterus salmoides) were the targeted species. Fish were examined in the field for internal and external visible gross lesions, selected organs were weighed to compute ponderal and organosomatic indices, and samples of tissues and fluids were obtained and preserved for analysis of fish health and reproductive biomarkers. Whole fish from each station were composited by species and gender and analyzed for organochlorine chemical residues and elemental contaminants using instrumental methods, and for 2,3,7,8-tetrachloro dibenzo-p-dioxin-like activity (TCDD-EQ) using the H4IIE rat hepatoma cell bioassay. Overall, fish from lower RGB stations contained greater concentrations of organochlorine pesticide residues and appeared to be less healthy than those from sites in the central and upper parts of the basin, as indicated by a general gradient of residue concentrations and biomarker responses. A minimal number of altered biomarkers and few or no elevated contaminant concentrations were noted in fish from the upper RGB. The exception was elevated concentrations [up to 0.46 ??g/g wet-weight (ww)] of total mercury (Hg) in predatory species from the Rio Grande at Elephant Butte Reservoir, NM, a condition documented in previous studies. Arsenic (As) and selenium (Se) concentrations were greatest in fish from sites in the central RGB; Se concentrations in fish from the Pecos River at Red Bluff Lake, TX and from the Rio Grande at Langtry, TX and Amistad International Reservoir, TX exceeded published

  13. O Debate do Salário Mínimo no Brasil

    Directory of Open Access Journals (Sweden)

    Sara Eloisa Vilmar da Silva Lemos

    2011-04-01

    Full Text Available Num contexto de estabilidade econômica, o salário mínimo pode voltar a desempenhar o seu papel original de tentar garantir ao trabalhador um salário que é o mínimo para a sua sobrevivência. Para a análise do papel do salario mínimo no mercado de trabalho brasileiro, uma resenha da literatura especifica existente parece ser um bom ponto de partida.

  14. Abnormal red cell structure and function in neuroacanthocytosis.

    Directory of Open Access Journals (Sweden)

    Judith C A Cluitmans

    Full Text Available Panthothenate kinase-associated neurodegeneration (PKAN belongs to a group of hereditary neurodegenerative disorders known as neuroacanthocytosis (NA. This genetically heterogeneous group of diseases is characterized by degeneration of neurons in the basal ganglia and by the presence of deformed red blood cells with thorny protrusions, acanthocytes, in the circulation.The goal of our study is to elucidate the molecular mechanisms underlying this aberrant red cell morphology and the corresponding functional consequences. This could shed light on the etiology of the neurodegeneration.We performed a qualitative and semi-quantitative morphological, immunofluorescent, biochemical and functional analysis of the red cells of several patients with PKAN and, for the first time, of the red cells of their family members.We show that the blood of patients with PKAN contains not only variable numbers of acanthocytes, but also a wide range of other misshapen red cells. Immunofluorescent and immunoblot analyses suggest an altered membrane organization, rather than quantitative changes in protein expression. Strikingly, these changes are not limited to the red blood cells of PKAN patients, but are also present in the red cells of heterozygous carriers without neurological problems. Furthermore, changes are not only present in acanthocytes, but also in other red cells, including discocytes. The patients' cells, however, are more fragile, as observed in a spleen-mimicking device.These morphological, molecular and functional characteristics of red cells in patients with PKAN and their family members offer new tools for diagnosis and present a window into the pathophysiology of neuroacanthocytosis.

  15. Resenha de 1976: Movimento Black Rio, de Luiz Felipe de Lima Peixoto e Zé Otávio Sabadelhe (Rio de Janeiro: José Olympio, 2016

    Directory of Open Access Journals (Sweden)

    Carlos Palombini

    2017-08-01

    Full Text Available Lançado em 10 de novembro de 2016, o livro 1976: Movimento Black Rio, dos jornalistas Luiz Felipe de Lima Peixoto e Zé Otávio Sabadelhe, celebra os quarenta anos da manchete de Lena Frias, Black Rio: o orgulho (importado de ser negro no Brasil, publicada em 17 de julho de 1976 no Caderno B do Jornal do Brasil. Em 28 reportagens, os autores recorrem a entrevistas e material previamente publicado para contar a história da cultura de bailes que, alimentados por soul, funk e disco afro-norte-americanos, espalharam-se pela Zona Norte carioca nos anos 1970, bem como a história do conjunto das apropriações desses gêneros por Tim Maia, Toni Tornado, Hyldon, Carlos Dafé, Cassiano, Gerson King Combo, Dom Salvador e Abolição, União Black, e Banda Black Rio. O livro tenciona constituir “uma contribuição à construção discursiva de uma memória social positiva da população negra brasileira” e oferece elementos para um trabalho necessário de revisão historiográfica que transcende o âmbito do tema tratado, apesar de erros fatuais que poderiam ter sido corrigidos por cruzamento de dados.

  16. Santuários, romarias e discipulado cristão

    Directory of Open Access Journals (Sweden)

    Edênio Valle

    2009-05-01

    Full Text Available O artigo trata basicamente da romaria e dos santuários populares católicos. Nascido de uma palestra feita a reitores de santuários católicos da América Latina, o artigo enfoca também o discipulado cristão como essencial no acolhimento aos romeiros. Sua perspectiva, porém, é a das ciências da religião e não a da teologia. A abordagem leva em conta as teorias sociológicas e psicoantropológicas hoje usadas na leitura do fenômeno das romarias nas religiões em geral e no cristianismo em especial. Após um rápido olhar sobre o sentido do discipulado na teologia e na Bíblia, o autor enfoca mais especificamente a abordagem psicoantropológica hoje em uso na sociologia dos santuários e das romarias. Finalizando, tece algumas considerações sobre a pastoral dos santuários e a necessidade de inserir o acolhimento religioso dos romeiros num contexto marcado pelo chamado turismo religioso.Palavras-chave: Santuários católicos; Pastoral das romarias; Discipulado; Psicologia da religião; Turismo religioso.ABSTRACT This article focuses on a discussion about Christian discipleship in the pastoral context of popular sanctuaries of the Catholic Church in Latin America. It is a reflection presented during the Latin American Congress of Catholic Sanctuaries in Aparecida, Brazil, in 2005. It considers different questions involved in the discussion, from the viewpoint of modern psycho-anthropology of pilgrimages and sanctuaries. After a short biblical-theological explanation of the meaning of Christian discipleship in theology and in the Bible, the article attempts to show what modern Brazilian and English-speaking experts in Anthropology and Pastoral Theology think about pilgrimages both in Christian and in non-Christian religions. Finally, it discusses the sanctuaries’ pastoral and the need to insert a religious welcome to pilgrims in the context of religious tourism.Key words: Catholic sanctuaries; Pastoral of pilgrimages; Discipleship

  17. Doppler interpretation of quasar red shifts.

    Science.gov (United States)

    Zapolsky, H S

    1966-08-05

    The hypothesis that the quasistellar sources (quasars) are local objects moving with velocities close to the speed of light is examined. Provided there is no observational cutoff on apparent bolometric magnitude for the quasars, the transverse Doppler effect leads to the expectation of fewer blue shifts than red shifts for an isotropic distribution of velocities. Such a distribution also yields a function N(z), the number of objects with red shift less than z which is not inconsistent with the present data. On the basis of two extreme assumptions concerning the origin of such rapidly moving sources, we computed curves of red shift plotted against magnitude. In particular, the curve obtained on the assumption that the quasars originated from an explosion in or nearby our own galaxy is in as good agreement with the observations as the curve of cosmological red shift plotted against magnitude.

  18. Red Wine Polyphenols for Cancer Prevention

    Science.gov (United States)

    He, Shan; Sun, Cuirong; Pan, Yuanjiang

    2008-01-01

    Conventional cancer therapies, the second leading cause of death worldwide, result in serious side effects and, at best, merely extend the patient's lifespan by a few years. Searching for effective prevention is of high priority in both basic and clinical sciences. In recent decades natural products have been considered to be an important source of cancer chemopreventive agents. Red wine polyphenols, which consisted of various powerful antioxidants such as flavonoids and stilbenes, have been implicated in cancer prevention and that promote human health without recognizable side effects. Since resveratrol, a major component of red wine polyphenols, has been studied and reviewed extensively for its chemopreventive activity to interfere with the multi-stage carcinogenesis, this review focuses on recent progress in studies on cancer chemopreventive activities of red wine polyphenol extracts and fractions as well as other red wine polyphenols, like procyanidin B5 analogues and myricetin. PMID:19325788

  19. Red Wine Polyphenols for Cancer Prevention

    Directory of Open Access Journals (Sweden)

    Yuanjiang Pan

    2008-05-01

    Full Text Available Conventional cancer therapies, the second leading cause of death worldwide, result in serious side effects and, at best, merely extend the patient's lifespan by a few years. Searching for effective prevention is of high priority in both basic and clinical sciences. In recent decades natural products have been considered to be an important source of cancer chemopreventive agents. Red wine polyphenols, which consisted of various powerful antioxidants such as flavonoids and stilbenes, have been implicated in cancer prevention and that promote human health without recognizable side effects. Since resveratrol, a major component of red wine polyphenols, has been studied and reviewed extensively for its chemopreventive activity to interfere with the multi-stage carcinogenesis, this review focuses on recent progress in studies on cancer chemopreventive activities of red wine polyphenol extracts and fractions as well as other red wine polyphenols, like procyanidin B5 analogues and myricetin.

  20. Marcos regulatórios e inovação no transporte rodoviário de produtos perigosos: o caso das embalagens vazias de agrotóxicos

    Directory of Open Access Journals (Sweden)

    Marne Lieggio Junior

    2011-05-01

    Full Text Available

    Resumo: O objetivo deste trabalho é analisar a inovação provocada pelos marcos regulatórios na logística do transporte rodoviário de produtos perigosos, especificamente na logística das embalagens de agrotóxicos. O quadro teórico de referência aborda a Teoria da Inovação, a questão de marcos regulatórios, riscos no transporte rodoviário de produtos perigosos e o necessário uso de rotinas. A metodologia utilizada na confecção do trabalho teve caráter exploratório, baseando-se em revisão bibliográfica e nas práticas operacionais de mercado. Os resultados da pesquisa mostraram que, ao adaptar-se às novas exigências legais do ambiente institucional em que se insere, a cadeia logística reversa de embalagens de agrotóxicos produziu inovações em seu processo, utilizando-se de “recursos produtos não-utilizados”, rotinas e lições aprendidas em sua trajetória tecnológica.

    Abstract: The objective of this study is to analyze the innovation caused by the regulatory framework in the logistics of transport of dangerous goods, specifically in the logistics of packing of pesticides. The theoretical frame of reference addresses: a Theory of Innovation, the question of regulatory framework, risks in road transport of dangerous goods and necessary use of routines. The methodology used in making the work was exploratory character, based on literature review and the operational practices of the market. The survey results showed that by adapting to new legal requirements of the institutional environment which includes the reverse supply chain of packaging for pesticides produced innovations in their process, applying unused productive resources (waste, routines and lessons learned in its history technology.