Sample records for rinderpest
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International Nuclear Information System (INIS)
2003-01-01
Rinderpest is probably the most lethal virus disease of cattle and buffalo and can destroy whole populations; damaging economies; undermining food security and ruining the livelihood of farmers and pastoralists. The disease can be eradicated by vaccination and control of livestock movement. The Department of Technical Co-operation is sponsoring a programme, with technical support from the Joint FAO/IAEA Division to provide advice, training and materials to thirteen states through the 'Support for Rinderpest Surveillance in West Asia' project. (IAEA)
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Biosecurity management recommendations for rinderpest laboratories
Energy Technology Data Exchange (ETDEWEB)
Brodsky, Benjamin H [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Caskey, Susan Adele [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Arndt, William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
2014-10-01
Rinderpest is a virus that can affect cattle and other even toes ungulates; evidence of outbreaks from over 10,000 years ago highlights the potential impact of this virus. During the 18th century, Rinderpest caused huge losses in cattle throughout Europe. Starting in the mid 1900’s vaccination efforts seemed feasible and work was initiated to vaccinate large populations of cattle. Walter Plowright received numerous awards for updating the Rinderpest vaccine which many believed would be the key to eradication. Vaccination of the disease lead to a massive drop in outbreaks and the last confirmed case of Rinderpest in Asia was in 2000 and in Africa in 2001.1 At this point, Rinderpest has been declared eradicated from nature. However, stocks of the virus are still in many laboratories.2 Rinderpest was investigated as a biological weapon agent during the Second World War. However, following WWII, rinderpest was not considered a high risk as a biological weapon as there was no direct military advantage. Now, with the concern of the use of biological agents as weapons in acts of terrorism, concern regarding rinderpest has resurfaced. Since the eradication of this virus, cattle populations are highly susceptibility to the virus and the economic impacts would be significant. This paper will discuss the specific nature of the terrorism risks associated with rinderpest; and based upon those risks provide recommendations regarding biosecurity management. The biosecurity management measures will be defined in a manner to align with the CWA 15793: the laboratory biorisk management document.
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Wambura, P N; Mollel, J O; Moshy, D W; Mbise, A N; Taylor, W P
1999-02-01
In January 1997, serum samples from 1346 adult sheep and goats were tested by a competitive ELISA to determine the prevalence of rinderpest in the northern zone of Tanzania. Seroconversion rates of 20%, 13%, 9%, 7% and 3% in sheep and goats were recorded in Ngorongoro, Monduli, Hai, Arumeru and Simanjiro districts, respectively. The low profile and insidious nature of the rinderpest virus involved caused very mild disease in cattle in some of these area. The mild signs associated with this outbreak of rinderpest resulted in difficulty in its diagnosis. In these circumstances, the presence of rinderpest antibody in sheep and goats served as a valuable and effective indicator of the rinderpest outbreak in cattle.
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Performance indicators for rinderpest surveillance
Energy Technology Data Exchange (ETDEWEB)
NONE
2001-12-01
In 1986, the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture initiated a programme of assistance to FAO and IAEA Member States for the development of effective, quality assured veterinary laboratory diagnostic services. This programme introduced the use of standardized and internationally validated ELISA-based systems for the diagnosis and surveillance of the major transboundary diseases that affect livestock. This approach has proved of immense value in the monitoring of national, regional and global animal disease control and eradication programmes. One such programme focuses on the global elimination of rinderpest. Co-ordinated by FAO through the Global Rinderpest Eradication Programme (GREP) the joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has developed critical diagnostic and epidemiological tools to assist this effort. As the final stages of the global eradication of rinderpest are reached, it is fitting that the Joint Division should again take the lead in providing guidance to Member States on how best to meet the criteria for quality assurance of national disease surveillance programmes - a prerequisite for international acceptance of freedom from a particular disease. This publication is intended to provide countries involved in rinderpest eradication with a detailed protocol for using performance indicators in evaluating their disease surveillance system and making, where necessary, adjustments to meet the criteria for acceptance specified in the OIE Rinderpest Pathway - a pathway that leads to international recognition of freedom from rinderpest. An initial publication (IAEA-TECDOC-1161) described guidelines for the use of performance indicators in rinderpest surveillance programmes. This publication now describes in detail the protocols and the linked indicators which have been developed and field validated through a series of FAO/IAEA meetings and through IAEA expert assignments to countries in Africa.
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Performance indicators for rinderpest surveillance
International Nuclear Information System (INIS)
2001-12-01
In 1986, the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture initiated a programme of assistance to FAO and IAEA Member States for the development of effective, quality assured veterinary laboratory diagnostic services. This programme introduced the use of standardized and internationally validated ELISA-based systems for the diagnosis and surveillance of the major transboundary diseases that affect livestock. This approach has proved of immense value in the monitoring of national, regional and global animal disease control and eradication programmes. One such programme focuses on the global elimination of rinderpest. Co-ordinated by FAO through the Global Rinderpest Eradication Programme (GREP) the joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has developed critical diagnostic and epidemiological tools to assist this effort. As the final stages of the global eradication of rinderpest are reached, it is fitting that the Joint Division should again take the lead in providing guidance to Member States on how best to meet the criteria for quality assurance of national disease surveillance programmes - a prerequisite for international acceptance of freedom from a particular disease. This publication is intended to provide countries involved in rinderpest eradication with a detailed protocol for using performance indicators in evaluating their disease surveillance system and making, where necessary, adjustments to meet the criteria for acceptance specified in the OIE Rinderpest Pathway - a pathway that leads to international recognition of freedom from rinderpest. An initial publication (IAEA-TECDOC-1161) described guidelines for the use of performance indicators in rinderpest surveillance programmes. This publication now describes in detail the protocols and the linked indicators which have been developed and field validated through a series of FAO/IAEA meetings and through IAEA expert assignments to countries in Africa
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Diagnosis of rinderpest in Tanzania by a rapid chromatographic strip-test.
Wambura, P N; Moshy, D W; Mbise, A N; Mollel, G O; Taylor, W P; Anderson, J; Bruning, A
2000-06-01
A simple chromatographic strip-test based on Clearview technology, is under development as a pen-side test for the detection of rinderpest antigen in eye swabs taken from cattle in the field. An outbreak of rinderpest occurred in the northern zone of Tanzania from late February to June 1997. The affected cattle exhibited very mild clinical signs, which made clinical diagnosis difficult. One hundred and seven eye swabs were collected from cattle suspected of infection with rinderpest. These were tested in the field using a prototype of the pen-side test and 13 (12.15%) of the samples were found to be positive for the presence of rinderpest antigen. These were confirmed by ICE. The positive cases were predominantly found in the Ngorongoro district. This demonstrates the usefulness of such a simple, rapid pen-side diagnostic assay, particularly when clinically 'mild' strains of rinderpest are present.
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Development of marker vaccines for rinderpest virus using reverse genetics technology
International Nuclear Information System (INIS)
Parida, S.; Walsh, E.P.; Anderson, J.; Baron, M.D.; Barrett, T.
2005-01-01
Rinderpest is an economically devastating disease of cattle (cattle plague), but a live-attenuated vaccine has been very successfully used in a global rinderpest eradication campaign. As a consequence, the endemic focus of the virus has been reduced to an area in eastern Africa known as the Kenya-Somali ecosystem. Although the vaccine is highly effective, it has a drawback in that vaccinated animals are serologically indistinguishable from those that have recovered from natural infection. In the final stages of the eradication campaign, when vaccination to control the spread of disease will only be used in emergencies to contain an outbreak, a marker vaccine would be a very useful tool to monitor possible wild virus spread outside the vaccination area. Marker vaccines for rinderpest, and other viruses with negative-sense RNA genomes, can now be produced using reverse genetics, and the development of such marker vaccines for rinderpest virus is described. (author)
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Characterization of membrane association of Rinderpest virus matrix protein
International Nuclear Information System (INIS)
Subhashri, R.; Shaila, M.S.
2007-01-01
Paramyxovirus matrix protein is believed to play a crucial role in the assembly and maturation of the virus particle by bringing the major viral components together at the budding site in the host cell. The membrane association capability of many enveloped virus matrix proteins has been characterized to be their intrinsic property. In this work, we have characterized the membrane association of Rinderpest virus matrix (M) protein. The M protein of Rinderpest virus when expressed in the absence of other viral proteins is present both in the cytoplasm and plasma membrane. When expressed as GFP fusion protein, the M protein gets localized into plasma membrane protrusions. High salt and alkaline conditions resulted in partial dissociation of M protein from cell membrane. Thus, M protein behaves like an integral membrane protein although its primary structure suggests it to be a peripheral membrane protein
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Kim, Dong Jin; Yoo, Han Sang; Lee, Hang
2014-04-01
This study clarifies the causes of the repetitive occurrences of such phenomena as rinderpest, epidemic, famine, and tiger disasters recorded in the Joseon Dynasty Chronicle and the Seungjeongwon Journals in the period of great catastrophe, the late 17th century in which the great Gyeongsin famine (1670~1671) and the great Eulbyeong famine (1695~1696) occurred, from the perspective that they were biological exchanges caused by the new arrival of rinderpest in the early 17th century. It is an objection to the achievements by existing studies which suggest that the great catastrophes occurring in the late 17th century are evidence of phenomena in a little ice age. First of all, rinderpest has had influence on East Asia as it had been spread from certain areas in Machuria in May 1636 through Joseon, where it raged throughout the nation, and then to the west part of Japan. The new arrival of rinderpest was indigenized in Joseon, where it was localized and spread periodically while it was adjusted to changes in the population of cattle with immunity in accordance with their life spans and reproduction rates. As the new rinderpest, which showed high pathogenicity in the early 17th century, was indigenized with its high mortality and continued until the late 17th century, it broke out periodically in general. Contrastively, epidemics like smallpox and measles that were indigenized as routine ones had occurred constantly from far past times. As a result, the rinderpest, which tried a new indigenization, and the human epidemics, which had been already indigenized long ago, were unexpectedly overlapped in their breakout, and hence great changes were noticed in the aspects of the human casualty due to epidemics. The outbreak of rinderpest resulted in famine due to lack of farming cattle, and the famine caused epidemics among people. The casualty of the human population due to the epidemics in turn led to negligence of farming cattle, which constituted factors that triggered
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Directory of Open Access Journals (Sweden)
Manore Carrie
2011-03-01
Full Text Available Abstract For the past decade, the Food and Agriculture Organization of the United Nations has been working toward eradicating rinderpest through vaccination and intense surveillance by 2012. Because of the potential severity of a rinderpest epidemic, it is prudent to prepare for an unexpected outbreak in animal populations. There is no immunity to the disease among the livestock or wildlife in the United States (US. If rinderpest were to emerge in the US, the loss in livestock could be devastating. We predict the potential spread of rinderpest using a two-stage model for the spread of a multi-host infectious disease among agricultural animals in the US. The model incorporates large-scale interactions among US counties and the small-scale dynamics of disease spread within a county. The model epidemic was seeded in 16 locations and there was a strong dependence of the overall epidemic size on the starting location. The epidemics were classified according to overall size into small epidemics of 100 to 300 animals (failed epidemics, epidemics infecting 3 000 to 30 000 animals (medium epidemics, and the large epidemics infecting around one million beef cattle. The size of the rinderpest epidemics were directly related to the origin of the disease and whether or not the disease moved into certain key counties in high-livestock-density areas of the US. The epidemic size also depended upon response time and effectiveness of movement controls.
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Contribution to the Eradication of Rinderpest in Somalia: the Experience of Terra Nuova
International Nuclear Information System (INIS)
2011-01-01
A mild form of rinderpest was described and diagnosed in Tsavo East National Park in Kenya in 1994, and subsequently in Nairobi National Park (in 1994 to 1996). Initially the Tsavo rinderpest outbreak was thought to have originated from southern Sudan, but molecular evidence clearly showed that the Tsavo virus was genetically very different from the isolates from Nairobi National Park and fell into the African type 2 lineage. The exact location of this focus was uncertain, but it was suspected that the virus could have remained undetected for several years in the Northeast Province of Kenya and the neighbouring Trans Juba Region of southern Somalia. When the Siad Barre regime collapsed in 1991, all public institutions, services and assets were seriously disrupted or looted. This was followed by massive displacement of people inside and outside Somalia, widespread insecurity, serious famine, and the collapse of most formal economic activities. To alleviate the consequences of the humanitarian crisis and the collapse of the Somali state, the international community launched a significant response, with peacekeeping operations, direct assistance to displaced populations, restoration of local administrations, rehabilitation of public infrastructures, and support to economic activities. Given its socio-economic importance and prominence, the livestock industry was one of the sectors targeted for relief and rehabilitation interventions, through mass vaccination campaigns against infectious diseases, curative treatments, rehabilitation of watering facilities, and training of veterinary professionals and para-veterinarians. During this period, rinderpest was one of the target diseases, especially in light of global efforts to eradicate the disease from the African continent, and particularly from Somalia, which was one of the last suspected foci of infection. Terra Nuova, one of 12 international non-governmental organizations (NGOs) initially involved in the livestock
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International Nuclear Information System (INIS)
Anderson, J.; McKay, J.A.; Butcher, R.N.
1991-01-01
A monoclonal antibody against the haemagglutinin of rinderpest virus has been used in a competitive ELISA (C-ELISA) for the detection of antibodies to rinderpest virus in cattle, sheep, goat and game sera. Unlike the indirect ELISA and the virus neutralisation test (VNT), the C-ELISA detects only antibodies to rinderpest virus and gives no cross-reactivity with antibodies to peste des petits ruminants (PPR) virus. Antibodies to a wide range of strains of rinderpest virus have been detected using this assay, suggesting its suitability for both sero-monitoring and sero-surveillance. Analysis of C-ELISA results from the examination of field sera shows a much greater separation of negative and positive populations as compared to the indirect ELISA. A further monoclonal antibody against the H protein of PPR has also been found suitable for use in a C-ELISA for the detection of antibodies to PPR virus. The use of these two C-ELISA's has made possible rapid differential sero-diagnosis without recourse to cross-VNT testing. The use of monoclonal antibody-based assays will allow much greater standardisation of rinderpest and PPR diagnosis, and following field-trials the C-ELISA will replace the indirect ELISA for sero-monitoring throughout the Pan African Rinderpest Campaign. (author). 3 refs, 6 figs, 1 tab
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Sunseri, Thaddeus
2015-01-01
Scholarship on the Tanzanian Rinderpest epizootic of the 1890s has assumed that German colonizers understood from the start that they were confronting the same disease that had afflicted Eurasia for centuries. Outward indicators of the epizootic, known locally as sadoka, especially wildlife destruction, were unknown in Europe, leading German veterinarians to doubt that the African disease was Rinderpest. Financial constraints and conflicting development agendas, especially tension between ranching and pastoralism, deterred early colonial applications of veterinary science that might have led to an early diagnosis. European veterinarians, guarding their authority against medical researchers, opposed inoculation therapies in the case of Rinderpest in favor of veterinary policing despite recent breakthroughs in vaccine research. The virus was not identified before reaching South Africa in 1896, but this breakthrough had little influence on policy in East Africa. Yet emergent international disease conventions directed at bubonic plague entangled with veterinary policy in East Africa.
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Ortiz-Pelaez, Angel; Pfeiffer, Dirk U; Tempia, Stefano; Otieno, F Tom; Aden, Hussein H; Costagli, Riccardo
2010-04-28
In contrast to most pastoral systems, the Somali livestock production system is oriented towards domestic trade and export with seasonal movement patterns of herds/flocks in search of water and pasture and towards export points. Data from a rinderpest survey and other data sources have been integrated to explore the topology of a contact network of cattle herds based on a spatial proximity criterion and other attributes related to cattle herd dynamics. The objective of the study is to integrate spatial mobility and other attributes with GIS and network approaches in order to develop a predictive spatial model of presence of rinderpest. A spatial logistic regression model was fitted using data for 562 point locations. It includes three statistically significant continuous-scale variables that increase the risk of rinderpest: home range radius, herd density and clustering coefficient of the node of the network whose link was established if the sum of the home ranges of every pair of nodes was equal or greater than the shortest distance between the points. The sensitivity of the model is 85.1% and the specificity 84.6%, correctly classifying 84.7% of the observations. The spatial autocorrelation not accounted for by the model is negligible and visual assessment of a semivariogram of the residuals indicated that there was no undue amount of spatial autocorrelation. The predictive model was applied to a set of 6176 point locations covering the study area. Areas at high risk of having serological evidence of rinderpest are located mainly in the coastal districts of Lower and Middle Juba, the coastal area of Lower Shabele and in the regions of Middle Shabele and Bay. There are also isolated spots of high risk along the border with Kenya and the southern area of the border with Ethiopia. The identification of point locations and areas with high risk of presence of rinderpest and their spatial visualization as a risk map will be useful for informing the prioritization of
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International Nuclear Information System (INIS)
Khandelwal, Abha; Renukaradhya, G.J.; Rajasekhar, M.; Sita, G. Lakshmi; Shaila, M.S.
2004-01-01
Rinderpest causes a devastating disease, often fatal, in wild and domestic ruminants. It has been eradicated successfully using a live, attenuated vaccine from most part of the world leaving a few foci of disease in parts of Africa, the Middle East, and South Asia. We have developed transgenic peanut (Arachis hypogaea L.) plants expressing hemagglutinin (H) protein of rinderpest virus (RPV), which is antigenically authentic. In this work, we have evaluated the immunogenicity of peanut-expressed H protein using mouse model, administered parenterally as well as orally. Intraperitoneal immunization of mice with the transgenic peanut extract elicited antibody response specific to H. These antibodies neutralized virus infectivity in vitro. Oral immunization of mice with transgenic peanut induced H-specific serum IgG and IgA antibodies. The systemic and oral immunogenicity of plant-derived H in absence of any adjuvant indicates the potential of edible vaccine for rinderpest
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International Nuclear Information System (INIS)
1994-05-01
One important activity of GREP is to recommend to the Office International des Epizooties (OIE) Member Countries a zoosanitary approach for achieving rinderpest eradication and for determining the effectiveness of this achievement. To this end, a Consultants Meeting on Animal Disease Surveillance Systems was held in Vienna from 27 September to 1 October 1993 under the auspices of FAO and IAEA. This document represents the conclusions of the meeting and attempts to outline, in a highly practical manner, the various factors to be taken into account and steps to be undertaken by a country in the process of moving along a zoosanitary pathway culminating in a declaration of freedom from rinderpest virus. 14 refs, 5 figs, 8 tabs
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Rossiter, P B; Hussain, M; Raja, R H; Moghul, W; Khan, Z; Broadbent, D W
1998-07-11
Between April 1994 and November 1995 the most severe epidemic of rinderpest reported in the world for over a decade affected domestic livestock in the Northern Areas of Pakistan. As many as 40,000 cattle and yaks died, more by some estimates, and mortality rates may have exceeded 80 per cent in these species in several villages. This report describes some of the clinicopathological and epidemiological features peculiar to the outbreak, including laboratory-confirmed rinderpest in a goat, and the difficulties encountered before the disease was eradicated. It also describes the human costs and emphasises the need to accelerate the global eradication of this most eradicable disease.
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The Use of Recombinant Hemagglutinine Protein of Rinderpest Virus in Enzyme Immunoassay
BULUT, Hakan; BOLAT, Yusuf
2003-01-01
In this study, Rinderpest virus (RPV) recombinant hemagglutinine protein (rH) fused with protein A region of Staphylococcus aureus was expressed in Escherichia coli and purified by IgG affinity chromatography. rH protein was also used to establish enzyme immunoassay. Therefore, to prevent IgG binding to the protein A the wells coated with the rH proteins were blocked by human serum. Afterwards, RPV antigens were added to the wells to evaluate this assay. To this end, serum from mice immunized...
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Eradication of Transboundary Animal Diseases: Can the Rinderpest Success Story be Repeated?
Thomson, G R; Penrith, M-L
2017-04-01
A matrix system was developed to aid in the evaluation of the technical amenability to eradication, through mass vaccination, of transboundary animal diseases (TADs). The system involved evaluation of three basic criteria - disease management efficiency, surveillance and epidemiological factors - each in turn comprised of a number of elements (17 in all). On that basis, 25 TADs that have occurred or do occur in southern Africa and for which vaccines are available, in addition to rinderpest (incorporated as a yardstick because it has been eradicated worldwide), were ranked. Cluster analysis was also applied using the same criteria to the 26 diseases, creating division into three groups. One cluster contained only diseases transmitted by arthropods (e.g. African horse sickness and Rift Valley fever) and considered difficult to eradicate because technologies for managing parasitic arthropods on a large scale are unavailable, while a second cluster contained diseases that have been widely considered to be eradicable [rinderpest, canine rabies, the Eurasian serotypes of foot and mouth disease virus (O, A, C & Asia 1) and peste des petits ruminants] as well classical swine fever, Newcastle disease and lumpy skin disease. The third cluster contained all the other TADs evaluated with the implication that these constitute TADs that would be more difficult to eradicate. However, it is acknowledged that the scores assigned in the course of this study may be biased. The point is that the system proposed offers an objective method for assessment of the technical eradicability of TADs; the rankings and groupings derived during this study are less important than the provision of a systematic approach for further development and evaluation. © 2015 Blackwell Verlag GmbH.
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Directory of Open Access Journals (Sweden)
P. Roeder
2009-09-01
Full Text Available Rinderpest is one of the few diseases which have changed the course of world history. Originally an Asian disease, for centuries it had a devastating impact in Europe when introduced by returning and marauding armies accompanied by cattle as well as by cattle trade. Nowhere was its impact more dramatically expressed than in Africa where the sequel to its introduction into the Horn of Africa was a devastating panzootic throughout sub-Saharan Africa during the last decade of the 19th century extending into the 20th century. Massive deaths of livestock, wild animals and the people dependent on them led to widespread human misery and changed the face of the African continent forever.
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International Nuclear Information System (INIS)
1994-11-01
1993 has been a significant year for PARC with the initiation of the Global Rinderpest Eradication Programme (GREP) providing a new emphasis in the drive towards the final elimination of rinderpest and its causative virus. For PARC this has culminated in a declaration by Egypt that it will cease vaccination at the beginning of 1994 and a strong commitment by a number of West African countries that they too will cease vaccination during 1994 and make the OIE Declarations of Provisional Freedom from Rinderpest. These significant steps forward in the eradication process would not have been possible without the information and confidence provided by the PARC sero-monitoring network. But even more important has been the clear demonstration that is possible to maintain the routine operation of an epidemiological network providing reliable results for a number of years in over 20 African countries. Such a system is vital if rinderpest is to be eradicated from the region and the bold move of a number of countries to now cease vaccinating is, in part, a testimony to the success of this network. This publication details the 1993 sero-monitoring results on a country to country basis, provides details of the external quality assurance programme and provides a series of conclusions and recommendations on the way to proceed in the future for this surveillance network. Refs, figs and tabs
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Studies on rinderpest disease in Sudan
Energy Technology Data Exchange (ETDEWEB)
Ismail, Mohamed Haroun [Faculty of Veterinary Science, University of Khartoum, Khartoum (Sudan)
1999-10-01
The pathogenesis and immunogenicity of two virulent rinderpest virus (RPV) field isolates and RPV vaccine strain (ROBK) were comparatively investigated in two groups of RP-susceptible calves of two cattle breeds. While the classical picture of RPV infection was reproduced in susceptible angus breed subgroup using the virulent RPV-saudi 1/81 strain, absence of one or more of the RPV cardinal signs was observed in the susceptible zebu breed calves infected with the virulent RPV-reedbuck (RPV-RB) strain. Successful recovery of the virulent RPV-saudi 1/81 strain from peripheral blood mononuclear cells (PBMCs) was attained in B95a lymphoid and modified monocytes human cell lines from day two post infection till death on day eight. Indirect immunofluorescence (IIF) using marina blue stain anti P monoclonal antibodies (MAbs), showed that PRV-P antigen was expressed on day four in case of PRV-saudi 1/81 infected B95a and MoMo cell lines. Polymerase chain reaction (PCR) was successfully used to retrieve PRV genomes from PBMCs of RPV-saudi 1/81on day two of infection till death on day eight and from their ocular and nasal swabs on days five, seven and nine post-infection. Viral genomes were retrieved from PBMCs of the subject vaccinated angus subgroup. Competitive enzyme-linked immunosorbent assay (c-ELISA) demonstrated that the two subject vaccinated angus breed calves responded positively to vaccination with the RBOK vaccine strain compared to 6/9 of the vaccinated zebu calves. None of the non-vaccinated control subgroups responded positively to challenge and the highest mean percentage inhibition (PI) was below 30. Stimulation indices (SIs) as high as 3.9 and 13.2 were showed by PBMCs from the vaccinated calves no. TQ94 and TQ95 on day 5 and 35 of vaccination, respectively. SI of 17.55 was shown by PBMCs from calf no. TQ94 two days postchallenge. Non of the non vaccinated control calves responded positively to the challenge virus. None of the vaccinated subgroups or the
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Studies on rinderpest disease in Sudan
International Nuclear Information System (INIS)
Ismail, Mohamed Haroun
1999-10-01
The pathogenesis and immunogenicity of two virulent rinderpest virus (RPV) field isolates and RPV vaccine strain (ROBK) were comparatively investigated in two groups of RP-susceptible calves of two cattle breeds. While the classical picture of RPV infection was reproduced in susceptible angus breed subgroup using the virulent RPV-saudi 1/81 strain, absence of one or more of the RPV cardinal signs was observed in the susceptible zebu breed calves infected with the virulent RPV-reedbuck (RPV-RB) strain. Successful recovery of the virulent RPV-saudi 1/81 strain from peripheral blood mononuclear cells (PBMCs) was attained in B95a lymphoid and modified monocytes human cell lines from day two post infection till death on day eight. Indirect immunofluorescence (IIF) using marina blue stain anti P monoclonal antibodies (MAbs), showed that PRV-P antigen was expressed on day four in case of PRV-saudi 1/81 infected B95a and MoMo cell lines. Polymerase chain reaction (PCR) was successfully used to retrieve PRV genomes from PBMCs of RPV-saudi 1/81on day two of infection till death on day eight and from their ocular and nasal swabs on days five, seven and nine post-infection. Viral genomes were retrieved from PBMCs of the subject vaccinated angus subgroup. Competitive enzyme-linked immunosorbent assay (c-ELISA) demonstrated that the two subject vaccinated angus breed calves responded positively to vaccination with the RBOK vaccine strain compared to 6/9 of the vaccinated zebu calves. None of the non-vaccinated control subgroups responded positively to challenge and the highest mean percentage inhibition (PI) was below 30. Stimulation indices (SIs) as high as 3.9 and 13.2 were showed by PBMCs from the vaccinated calves no. TQ94 and TQ95 on day 5 and 35 of vaccination, respectively. SI of 17.55 was shown by PBMCs from calf no. TQ94 two days postchallenge. Non of the non vaccinated control calves responded positively to the challenge virus. None of the vaccinated subgroups or the
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International Nuclear Information System (INIS)
Masmudur Rahman, Md.; Shaila, M.S.; Gopinathan, Karumathil P.
2003-01-01
Recombinant Bombyx mori nucleopolyhedroviruses (BmNPV) displaying the immunodominant ectodomains of fusion glycoprotein (F) of Peste des petitis ruminants virus (PPRV) and the hemagglutinin protein (H) of Rinderpest virus (RPV), on the budded virions as well as the surface of the infected host cells have been constructed. The F and H protein sequences were inserted in-frame within the amino-terminal region of BmNPV envelope glycoprotein GP64 expressing under the strong viral polyhedrin (polh) promoter. We improved the recombinant virus selection in BmNPV by incorporating the green fluorescent protein gene (gfp) as selection marker under a separate promoter within the transfer cassette harboring the desired genes. Following infection of the insect larvae or the host-derived BmN cells with these recombinant BmNPVs, the expressed GP64 fusion proteins were displayed on the host cell surface and the budded virions. The antigenic epitopes of the recombinant proteins were properly displayed and the recombinant virus particles induced immune response in mice against PPRV or RPV
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Animal production and health newsletter. No. 33
International Nuclear Information System (INIS)
2000-12-01
A full report on the final research coordination meeting on the long running Coordinated Research Project supporting rinderpest eradication is contained in this Newsletter. It is reported that all the national rinderpest vaccination campaigns have been terminated and except for a very few isolated areas where vaccination continues, the effort is now on disease surveillance to demonstrate freedom from rinderpest. Other research coordination meetings on animal diseases and productivity as well as new projects are highlighted in this issue
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Animal production and health newsletter. No. 33
Energy Technology Data Exchange (ETDEWEB)
NONE
2000-12-01
A full report on the final research coordination meeting on the long running Coordinated Research Project supporting rinderpest eradication is contained in this Newsletter. It is reported that all the national rinderpest vaccination campaigns have been terminated and except for a very few isolated areas where vaccination continues, the effort is now on disease surveillance to demonstrate freedom from rinderpest. Other research coordination meetings on animal diseases and productivity as well as new projects are highlighted in this issue.
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Tempia, S; Salman, M D; Keefe, T; Morley, P; Freier, J E; DeMartini, J C; Wamwayi, H M; Njeumi, F; Soumaré, B; Abdi, A M
2010-12-01
A cross-sectional sero-survey, using a two-stage cluster sampling design, was conducted between 2002 and 2003 in ten administrative regions of central and southern Somalia, to estimate the seroprevalence and geographic distribution of rinderpest (RP) in the study area, as well as to identify potential risk factors for the observed seroprevalence distribution. The study was also used to test the feasibility of the spatially integrated investigation technique in nomadic and semi-nomadic pastoral systems. In the absence of a systematic list of livestock holdings, the primary sampling units were selected by generating random map coordinates. A total of 9,216 serum samples were collected from cattle aged 12 to 36 months at 562 sampling sites. Two apparent clusters of RP seroprevalence were detected. Four potential risk factors associated with the observed seroprevalence were identified: the mobility of cattle herds, the cattle population density, the proximity of cattle herds to cattle trade routes and cattle herd size. Risk maps were then generated to assist in designing more targeted surveillance strategies. The observed seroprevalence in these areas declined over time. In subsequent years, similar seroprevalence studies in neighbouring areas of Kenya and Ethiopia also showed a very low seroprevalence of RP or the absence of antibodies against RP. The progressive decline in RP antibody prevalence is consistent with virus extinction. Verification of freedom from RP infection in the Somali ecosystem is currently in progress.
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Diagnosis of animal diseases using nuclear and related techniques: Developments and trends
International Nuclear Information System (INIS)
Anderson, J.; McKay, J.A.
1991-01-01
Nuclear techniques such as radioimmune precipitation, radioimmunoassay, DNA cloning and amino acid sequencing have led to a greater understanding of protein structure and function, antigenic variation and the immune response to infection. Knowledge gained from the use of this technology has led to the development of improved diagnostic assays. Although radioimmunoassay has been used for animal disease diagnosis for many years, more recently it has been replaced by the enzyme linked immunosorbent assay (ELISA). The ELISA offers advantages in speed of reading and longer reagent shelf life and obviates the use of radiochemicals. This is particularly important in developing countries, which may have no facilities for storage, handling and disposal of radioactive materials. In the case of rinderpest diagnosis, taken as an example, the virus neutralization test was replaced by a simple indirect ELISA for seromonitoring throughout the Pan-African Rinderpest Campaign. In the near future, this will be replaced by a competitive ELISA using a rinderpest specific monoclonal antibody, which will offer significant advantages in sensitivity and specificity. In the future it may be possible to replace the rinderpest antigen with vector expressed proteins or synthetic polypeptides. More recent developments such as the 'amplified' ELISA and the use of fluorogenic and bioluminescent substrates may further improve disease diagnosis. The knowledge gained from the use of modern technology is essential to the development of improved diagnostic assays which in turn will lead to improved disease diagnosis and control. (author). 9 refs
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Drought, ecological crisis and famine in late nineteenth century south-eastern Africa
Pribyl, Kathleen; Nash, David J.; Klein, Jørgen; Endfield, Georgina H.
2017-04-01
In the second half of the 1890s a drought-driven ecological crisis took hold in the region of modern-day Botswana, Zimbabwe and northern, central and eastern South Africa. A number of years of very late rainy seasons had severe repercussions for the rain-fed agriculture. Sowing was delayed and the young crops suffered from below average summer rainfall levels. Drawing on a wide variety of documentary sources - administrative records, writings by members of missionary societies and local newspapers - this paper outlines how the drought drove the ecological crisis and aggravated a locust infestation and the cattle plague (rinderpest). Whereas the locusts found better breeding conditions in areas that were normally too humid for them, the drought also facilitated the spread of rinderpest by reducing the number of watering holes and by forcing the cattle into an immunodepressed state due to malnutrition. The locusts contributed to the loss of grain crops, and the rinderpest decimated cattle herds by more than 90 per cent in areas where the disease coincided with the drought. As agriculture as well as the pastoral sector were hit hard, famine conditions developed in the interior of the region.
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78 FR 56857 - Submission for OMB Review; Comment Request
2013-09-16
..., Office of Management and Budget (OMB), New Executive Office Building, 725 17th Street NW., Washington, DC... States is free of rinderpest, foot-and-mouth disease, classical swine fever, swine vesicular disease...
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Animal production and health newsletter. No. 32
International Nuclear Information System (INIS)
2000-06-01
Project reviews and research coordination meetings on milk production, rinderpest diagnosis, animal vaccinations, quality assurance in veterinary diagnostic laboratories and evaluation of animal feeds are the major highlights of this issue of the Newsletter
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2011-10-03
... representing the Federal life sciences, public health, law enforcement, security, and intelligence communities...-mouth disease virus and rinderpest virus due to the particular dangers posed by these two viruses. Foot... products or ingestion of contaminated milk, artificial insemination, and inhalation of infectious aerosols...
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African Journals Online (AJOL)
Items 151 - 200 of 498 ... Vol 29, No 3 (2008), Emerging zoonoses: the public health role of ... of peste des petits ruminant and Rinderpest virus infection of camels in Borno and ... Vol 37, No 4 (2016), Fatal obstructive asphyxiation due to rumen ...
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2010-01-01
... OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS RINDERPEST, FOOT-AND-MOUTH DISEASE, EXOTIC... encephalopathy. (e) Meat or dressed carcasses of hunter-harvested wild sheep, goats, or other ruminants other than cervids. The meat or dressed carcass (eviscerated and the head is removed) is derived from a wild...
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2010-01-01
... poultry, poultry meat, and other poultry products from specified regions. 94.26 Section 94.26 Animals and... IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS RINDERPEST, FOOT-AND-MOUTH DISEASE, EXOTIC... poultry, poultry meat, and other poultry products from specified regions. Argentina and the Mexican States...
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Animal Production and Health Newsletter, No. 54, July 2011
International Nuclear Information System (INIS)
2011-07-01
It is with great enthusiasm that I address you in a new era - the era of a rinderpest free world. The OIE and FAO have declared the world-wide eradication of Rinderpest recently - but more about this later. The first part of this year has been a busy time for all personnel in the subprogramme. Apart from our regular Coordinated Research Project (CRP) activities and our technical support given to national and regional Technical Cooperation projects (TC), we were involved in the technical planning of projects for the new TC projects by Member States for the 2012/2013 biennial project cycle. We were also occupied with finalizing the IAEA's 2012/2013 Work and Budget Programme. It is hoped that our inputs will serve the best interests of our Member States. Please look at our web site and our Animal Production and Health Newsletter to familiarize yourselves with all the activities of the subprogramme
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2010-01-13
... Rinderpest AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION: Final rule; delay of effective... the final rule. This delay will allow the Animal and Plant Health Inspection Service to consider the.... Therefore, we are delaying the effective date of the final rule indefinitely. This delay will allow the...
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2010-01-01
... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Importation of poultry meat and other poultry products from Sinaloa and Sonora, Mexico. 94.23 Section 94.23 Animals and Animal Products ANIMAL... (INCLUDING POULTRY) AND ANIMAL PRODUCTS RINDERPEST, FOOT-AND-MOUTH DISEASE, EXOTIC NEWCASTLE DISEASE, AFRICAN...
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2003-01-01
including measles virus (MeV), mumps virus, Sendai virus (SeV), Newcastle disease virus (NDV), rinderpest virus, canine distemper virus (CDV), human...Institute of Health, Bethesda, MD. Hut 102, MT2, MT4, and CEM human T cell lines were provided by Chou-Zen Giam, USUHS, Bethesda, MD. The human osteosarcoma
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Animal production and health newsletter. No. 31
International Nuclear Information System (INIS)
1999-12-01
Detailed accounts of Research coordination Meetings on 'Support for rinderpest surveillance', 'Use of immunoassay for improved diagnosis of trypanosomiasis and monitoring of tsetse and trypanosomiasis control programmes in africa' and meetings related to milk and meat production are presented in this issue. Recent training activities and other meetings are also highlighted
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Animal production and health newsletter. No. 31
Energy Technology Data Exchange (ETDEWEB)
NONE
1999-12-01
Detailed accounts of Research coordination Meetings on 'Support for rinderpest surveillance', 'Use of immunoassay for improved diagnosis of trypanosomiasis and monitoring of tsetse and trypanosomiasis control programmes in africa' and meetings related to milk and meat production are presented in this issue. Recent training activities and other meetings are also highlighted.
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International Nuclear Information System (INIS)
Berguido, F.J.; Bodjo, S.C.; Loitsch, A.; Diallo, A.
2016-01-01
Full text: Peste des petits ruminants (PPR) is a contagious and often fatal transboundary animal disease affecting mostly sheep, goats and wild small ruminants. This disease is endemic in most of Africa, the Middle, Near East, and large parts of Asia. The casual agent is peste des petits ruminants virus (PPRV), which belongs to the genus Morbilivirus in the family Paramyxoviridae. This genus also includes measles virus (MV), canine distemper virus (CDV) and rinderpest virus (RPV). All are closely related viruses with serological cross reactivity. In this study, we have developed a Luciferase Immunoprecipitation System (LIPS) for the rapid detection of antibodies against PPRV in serum samples and for specific differentiation from antibodies against RPV. PPR and rinderpest (RP) serum samples were assayed by PPR-LIPS and two commercially available PPR cELISA tests. The PPR-LIPS showed high sensitivity and specificity for the samples tested and showed no cross reactivity with RPV unlike the commercial PPR cELISA tests which did not cross react with RPV. Based on the results shown in this study, PPR-LIPS is presented as a good candidate for the specific serosurveillance of PPR. (author)
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2009-01-01
Morbillivirus Measles Virus Canine Distemper virus Rinderpest virus Respirovirus Bovine Parainfluenzavirus 3 Human Parainfluenzavirus 1,3...M. D. Curran, and B. K. Rima. 1997. Nucleotide sequence analysis of the large (L) genes of Phocine Distemper virus and Canine Distemper virus...components of Canine Distemper virus. J Gen Virol 66 ( Pt 3):443-56. 115. Parashar, U. D., L. M. Sunn, F. Ong, A. W. Mounts, M. T. Arif, T. G. Ksiazek
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1988-06-20
191,800, up 1.5 percent from 1986. The total included 78,400 doctors, 38,900 nurses , and 74,500 other health workers. Progress was made in disease...eliminated rinderpest; essentially brought pleurop- neumonia, brucellosis, foot-and-mouth disease, anthrax, equine infectious anemia, swine erysipelas...investments of 4.5 billion yuan to build livestock commodity bases during the Seventh 5-Year Plan and 1 billion yuan for grassland construction, veterinary
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International Nuclear Information System (INIS)
1994-01-01
As part of the programme of support to scientists in developing countries, the Joint FAO/IAEA Division has developed and distributed ELISA kits for detecting both the causative agent and the immune response of animals to a number of the major diseases affecting livestock. In many cases these kits are now being used as part of national and international control and/or eradication programmes (e.g. for rinderpest, trypanosomosis, foot and mouth disease, brucellosis) and are likely to form the basis for establishing a country's freedom from particular diseases (e.g. rinderpest) at the national and international level. To further encourage international trade in livestock and livestock products, and to assist in the regional or global control and eradication of a number of the major diseases affecting livestock, there has been a strong move towards international standardization for animal disease diagnosis. Central to this is the need for internal and external quality assurance procedures to ensure that a standardized approach is being adhered to and that the results can be relied upon. In 1992, an FAO/IAEA consultants meeting was convened to define and establish for the ELISA, standards for internal quality control of reagents and procedures and for the expression of results. The recommendations of that meeting have now been incorporated in all FAO/IAEA ELISA kits and have been adopted by the OIE (Office International des Epizooties). The primary function of the internal quality controls is to ensure that the assay is performing within defined limits. Equally important, is an assurance to all outside interested bodies (national veterinary authorities, international organizations, donor organizations, trading partners) that the results being provided by a laboratory are valid. The procedures for ascertaining this assurance would form the basis of an external quality assurance programme (EQAP). Between 1990 and 1993, as part of establishing an EQAP, laboratories using
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Morbillivirus vaccines: recent successes and future hopes.
Buczkowski, Hubert; Muniraju, Murali; Parida, Satya; Banyard, Ashley C
2014-05-30
The impact of morbilliviruses on both human and animal populations is well documented in the history of mankind. Indeed, prior to the development of vaccines for these diseases, morbilliviruses plagued both humans and their livestock that were heavily relied upon for food and motor power within communities. Measles virus (MeV) was responsible for the death of millions of people annually across the world and those fortunate enough to escape the disease often faced starvation where their livestock had died following infection with rinderpest virus (RPV) or peste des petits ruminants virus (PPRV). Canine distemper virus has affected dog populations for centuries and in the past few decades appears to have jumped species, now causing disease in a number of non-canid species, some of which are been pushed to the brink of extinction by the virus. During the age of vaccination, the introduction and successful application of vaccines against rinderpest and measles has led to the eradication of the former and the greater control of the latter. Vaccines against PPR and canine distemper have also been generated; however, the diseases still pose a threat to susceptible species. Here we review the currently available vaccines against these four morbilliviruses and discuss the prospects for the development of new generation vaccines. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.
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Animal Production and Health Newsletter, No. 53, January 2011
Energy Technology Data Exchange (ETDEWEB)
NONE
2011-01-15
In this newsletter I want to highlight the biggest event on the animal calendar - Rinderpest is no longer a threat to livestock farmers' world wide. It is expected that FAO and OIE will jointly declare the world to be free from Rinderpest in 2011. In commemoration of this, I want to pay tribute to the members that made this possible such as regional organizations (EC, AU/IBAR CG-Centres etc), international organizations (FAO, OIE, IAEA etc), individual countries (France, Japan, The Netherlands, United Kingdom, United States of America, Italy etc) and the Member States that suffered from this disease and worked towards its eradication. Together with all the role players, the Joint FAO/IAEA Division and the IAEA Technical Cooperation Department's contribution to the development, evaluation and validation of nuclear and nuclear related immunological and molecular diagnostic technologies was a niche and critical area. The International Atomic Energy Agency (IAEA) has two mechanisms of technical support to Member States - the development, evaluation and validation of nuclear and nuclear related technologies through the Coordinated Research Project (CRP) mechanism, and the transfer and sustainable implementation of the CRP developed technologies through the IAEA's Technical Cooperation Project (TCP) mechanism. The development of nuclear and nuclear related immunological and molecular diagnostic technologies were jointly developed between CRPs of the Joint FAO/IAEA Division and TCPs of the Technical Cooperation Department
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Animal Production and Health Newsletter, No. 53, January 2011
International Nuclear Information System (INIS)
2011-01-01
In this newsletter I want to highlight the biggest event on the animal calendar - Rinderpest is no longer a threat to livestock farmers' world wide. It is expected that FAO and OIE will jointly declare the world to be free from Rinderpest in 2011. In commemoration of this, I want to pay tribute to the members that made this possible such as regional organizations (EC, AU/IBAR CG-Centres etc), international organizations (FAO, OIE, IAEA etc), individual countries (France, Japan, The Netherlands, United Kingdom, United States of America, Italy etc) and the Member States that suffered from this disease and worked towards its eradication. Together with all the role players, the Joint FAO/IAEA Division and the IAEA Technical Cooperation Department's contribution to the development, evaluation and validation of nuclear and nuclear related immunological and molecular diagnostic technologies was a niche and critical area. The International Atomic Energy Agency (IAEA) has two mechanisms of technical support to Member States - the development, evaluation and validation of nuclear and nuclear related technologies through the Coordinated Research Project (CRP) mechanism, and the transfer and sustainable implementation of the CRP developed technologies through the IAEA's Technical Cooperation Project (TCP) mechanism. The development of nuclear and nuclear related immunological and molecular diagnostic technologies were jointly developed between CRPs of the Joint FAO/IAEA Division and TCPs of the Technical Cooperation Department
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Animal health and production in the Tihama area of the Yemen Arab Republic
Directory of Open Access Journals (Sweden)
Stafford, K.
1989-01-01
Full Text Available Livestock and poultry production throughout the Tihama has developed to suit the agricultural necessities of the region. Livestock in general exist off agricultural by-products and semi-arid land and are not in competition with the human requirement for grains. Such economic production needs not be modified in its essentials. Rinderpest, foot and mouth disease and contagious caprine pleuro pneumonia are the major hindrance to livestock productivity. Malnutrition though a problem can easily be countered with phosphorus and other mineral supplementation.
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Control strategies for peste des petits ruminants in small ruminants of India.
Singh, R P
2011-12-01
Peste des petits ruminants (PPR) is a contagious viral disease of small ruminants. It is endemic in several African, Middle Eastern and Asian countries, including India. India has recently taken comprehensive steps to deal with PPR through the development and production of potent vaccines and monoclonal-antibody-based diagnostic kits, while also gathering baseline information on the disease situation and human resources. As a result, PPR can now be controlled by focused vaccinations in high-risk populations of sheep and goats, followed by mass vaccination campaigns. Mass vaccination campaigns must achieve high levels of herd immunity (70% to 80%) to block the epidemic cycle of the virus. With the tools currently available, disease control and subsequent eradication programmes for PPR may be a feasible option, following the example of the National Rinderpest Eradication Programme, which has successfully eradicated rinderpest from India. An understanding of the cultural and socio-economic circumstances of goat and sheep owners and a keen watch on the endemic nature of PPR in neighbouring countries will enhance the success of this approach. Coordinated efforts from all stakeholders, combined with proper funding and execution of control programmes, will be needed to achieve the goal of a PPR-free India. In addition, the availability of effective combined vaccines of PPR with goat pox or sheep pox offers a cost-effective way of simultaneously launching control programmes against all three of these diseases.
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[Role of vaccination in animal health].
Pastoret, Paul-Pierre
2012-03-01
According to the IFAH, veterinary vaccines currently account for 26% of the global market in veterinary medicines, reflecting the importance of vaccines in animal health, as well as the number of wild and domesticated target species, and the monospecific nature of most vaccines. Multispecies vaccines include tetanus and rabies. In 2010, the number of food-producing animals was estimated to be roughly 20 billion and is rising gradually. Fowl currently represent the main food species. Veterinary vaccination has allowed the eradication of rinderpest, as officially declared last year (2011), jointly by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation of the United Nations (FAO). Rinderpest was a real scourge, and was only the second viral disease to be totally eradicated (after human smallpox). One characteristic of veterinary vaccination is the DIVA approach, "differentiating infected from vaccinated animals". The DIVA strategy is especially interesting for regulated control of diseases like foot-and-mouth disease, infectious bovine rhinotracheitis, pseudorabies, and classical swine fever. DIVA vaccination requires prior serological testing. Vaccination is also used for wild animals such as foxes (rabies) and wild boars (classical swine fever). "In ovo" vaccination of fowl on day 18 of the incubation period is used to prevent Marek's disease for instance, and double vaccination (vector and insert) to prevent both Marek's disease and Gumboro's disease in fowl. Animal vaccination can also help to protect human health, as illustrated by fowl vaccination against salmonellosis.
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DEFF Research Database (Denmark)
Simonsen, Bo Thisted; Siegismund, H R; Arctander, P
1998-01-01
The African buffalo (Syncerus caffer) is widespread throughout sub-Saharan Africa and is found in most major vegetation types, wherever permanent sources of water are available, making it physically able to disperse through a wide range of habitats. Despite this, the buffalo has been assumed...... and analysis of variation at six microsatellite loci among 11 localities in eastern and southern Africa. High levels of genetic variability were found, suggesting that reported severe population bottlenecks due to outbreak of rinderpest during the last century did not strongly reduce the genetic variability...
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Use of enzyme immunoassays in disease diagnosis, with particular reference to rinderpest
International Nuclear Information System (INIS)
Crowther, J.R.
1986-01-01
The wider principles of the use of enzyme linked immunosorbent assays (ELISA) in diagnosis are illustrated. The development of an antirinderpest antibody assay is explained in order to demonstrate the relative ease with which the test can be set up and used in various countries. The various stages of the test can be standardized in central laboratories; for example, antigen (inactivated) can be prepared and passively attached to microplates. Purchasing and titration of conjugates and selection of negative control sera could also be done centrally. Thus 'kits' for the initiation of diagnosis could be rapidly made available. When assays have been used in specific countries to study antibody populations in large numbers of animals, it may be found necessary to modify the above procedures; for example, different negative sera may be necessary, reflecting the mean (and distribution) of the country. Relatively simple standardization steps to titrate antigen, conjugates and sera would allow assays to be set up in individual countries with no need for outside standardization. However, it may be useful to obtain sero-negative and sero-positive standards from an outside source which could be used on a worldwide basis for interlaboratory standardization. The provision of washing solution, blocking buffers, plates, pipettes and readers is the only requisite for the versatility of ELISA to be fully realized in the study of many disease agents. (author)
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Directory of Open Access Journals (Sweden)
Senthil K Chinnakannan
Full Text Available Morbilliviruses form a closely related group of pathogenic viruses which encode three non-structural proteins V, W and C in their P gene. Previous studies with rinderpest virus (RPV and measles virus (MeV have demonstrated that these non-structural proteins play a crucial role in blocking type I (IFNα/β and type II (IFNγ interferon action, and various mechanisms have been proposed for these effects. We have directly compared four important morbilliviruses, rinderpest (RPV, measles virus (MeV, peste des petits ruminants virus (PPRV and canine distemper virus (CDV. These viruses and their V proteins could all block type I IFN action. However, the viruses and their V proteins had varying abilities to block type II IFN action. The ability to block type II IFN-induced gene transcription correlated with co-precipitation of STAT1 with the respective V protein, but there was no correlation between co-precipitation of either STAT1 or STAT2 and the abilities of the V proteins to block type I IFN-induced gene transcription or the creation of the antiviral state. Further study revealed that the V proteins of RPV, MeV, PPRV and CDV could all interfere with phosphorylation of the interferon-receptor-associated kinase Tyk2, and the V protein of highly virulent RPV could also block the phosphorylation of another such kinase, Jak1. Co-precipitation studies showed that morbillivirus V proteins all form a complex containing Tyk2 and Jak1. This study highlights the ability of morbillivirus V proteins to target multiple components of the IFN signalling pathways to control both type I and type II IFN action.
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Animal Production and Health Newsletter, No. 55, January 2012
International Nuclear Information System (INIS)
2012-01-01
The biggest event in 2011 was the declaration of global freedom from rinderpest by the Food and Agriculture Organization of the United Nations and the World Organisation for Animal Health (OIE). The IAEA celebrated this momentous occasion on the 20th of September 2011, during the IAEA 55th General Conference. The commitment, dedication and hard work of past and present IAEA staff were commended by all participants as the contribution of the IAEA was a critical and essential component of the eradication success. Building on the success of the rinderpest campaign, technology transfer in the field of animal health continued to be a top priority of the Subprogramme during 2011 and this will continue for the future since our next target disease for eradication is peste des petits ruminants (PPR). Member States received support through Technical Cooperation Projects. In most of the tropics, climatic variation, rainfall patterns and droughts reduce plant growth and feed availability and quality leading to extensive livestock losses and reduced productivity. With the assistance of the IAEA, tremendous improvement has been achieved in terms of quantity and quality of the available feed resource base, particularly, in terms of nutritive value, palatability and/or cold and drought tolerance - vital benefits whose effectiveness can be monitored using nuclear technology. Both past and future activities are described in detail in this newsletter and are also accessible at our website (http://www-naweb.iaea.org/nafa/aph/index.html); I thus need not mention them in this section. Please contact us if you have any further ideas, comments, concerns or questions. As discussed in previous newsletters, the Animal Production and Health Subprogramme will continue to move progressively forward and in pace with developments within the livestock field, to optimally serve our Member States.
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Animal production and health newsletter. No. 43
International Nuclear Information System (INIS)
2005-12-01
As part of our regular Coordinated Research Project (CRP) activities and our technical support given to ongoing national and regional Technical Cooperation projects (TCPs), the Section evaluated our activities as part of the Agency's 2004/2005 midterm performance evaluation. During this exercise we could identify areas where good performances were achieved as well as those where further improvements were needed and which we then addressed. It became apparent that more proactive measures are needed towards the detection, control and management of emerging diseases, with particular emphasis on transboundary animal diseases and the offering of relevant support to Member States. A particular case in point is the current avian influenza situation. This issue discussed the problem posed by rinderpest and the Agency's effort in eradicating this viral disease
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9 CFR 94.1 - Regions where rinderpest or foot-and-mouth disease exists; importations prohibited.
2010-01-01
..., Guatemala, Haiti, Honduras, Hungary, Iceland, Ireland, Italy, Jamaica, Japan, Latvia, Lithuania, Luxembourg, Mexico, Namibia (excluding the region north of the Veterinary Cordon Fence), The Netherlands, New... signed by an authorized official of the national animal health service of the exporting region that...
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DEFF Research Database (Denmark)
Muwanika, Vincent B.; Kock, Richard; Masembe, Charles
2012-01-01
in a population of the desert warthog (Phacochoerus aethiopicus) sampled from 12 localities in its natural range in eastern Africa. From the total sample (30 individuals), at the six microsatellite loci that were analysed, a total of 43 alleles was observed averaging seven alleles per locus. Expected...... heterozygosity (HE) per locus was high, ranging from 0.53 to 0.87. At the mitochondrial loci, nucleotide diversity was low (p = 0.12%) with two unique haplotypes observed from the 19 individuals that amplified successfully. The diversity indices observed in the desert warthog are comparable to those previously...... reported for the closely related but widespread species, the common warthog (Phacochoerus africanus). These results suggest that the desert warthog is not genetically depauperate despite the rinderpest epidemic of the 1880s that eliminated it from most of its natural range....
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Morbillivirus Infections: An Introduction
Directory of Open Access Journals (Sweden)
Rory D. de Vries
2015-02-01
Full Text Available Research on morbillivirus infections has led to exciting developments in recent years. Global measles vaccination coverage has increased, resulting in a significant reduction in measles mortality. In 2011 rinderpest virus was declared globally eradicated – only the second virus to be eradicated by targeted vaccination. Identification of new cellular receptors and implementation of recombinant viruses expressing fluorescent proteins in a range of model systems have provided fundamental new insights into the pathogenesis of morbilliviruses, and their interactions with the host immune system. Nevertheless, both new and well-studied morbilliviruses are associated with significant disease in wildlife and domestic animals. This illustrates the need for robust surveillance and a strategic focus on barriers that restrict cross-species transmission. Recent and ongoing measles outbreaks also demonstrate that maintenance of high vaccination coverage for these highly infectious agents is critical. This introduction briefly summarizes the most important current research topics in this field.
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9 CFR 94.4 - Cured or cooked meat from regions where rinderpest or foot-and-mouth disease exists.
2010-01-01
... establishment must wash their hands and change into the clean clothing and boots provided in the changing rooms... broiled at 210 °C for at least 133 seconds, then cooked in moist heat (steam heat) in a continuous, belt... baskets for disposal, and changing rooms stocked with the clean clothing and rubber boots into which all...
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International Nuclear Information System (INIS)
1998-01-01
Livestock diseases remain a key constraint to livestock production in developing countries. Diseases like rinderpest, foot-and-mouth disease, brucellosis, trypanosomosis, tick borne diseases such as anaplasmosis, heartwater and East Coast fever, contagious bovine pleuropneumonia and Newcastle disease have caused great economic losses in various parts of the world. The control, and ultimate eradication where possible, of these and other diseases is important for the economies of many nations. It is for this reason that both the IAEA and the FAO have put great emphasis on the control and eradication of livestock diseases. The success of any disease control or eradication programme relies heavily on the robustness and efficacy of tile diagnosis, surveillance or seromonitoring method or methods being used. Nuclear based and related techniques such as enzyme linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) have played and continue to play a vital role in this regard. The aim of this symposium is to review existing and emerging techniques used in disease diagnosis and control and to carefully put them in context for use in developing countries in the future
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Animal production and health newsletter. No. 28
International Nuclear Information System (INIS)
1998-06-01
As we move into the second half of 1998, it is appropriate to look forward to 1999 which will see the commencement of four new FAO/IAEA Co-ordinated Research Projects (CRP) and the initiation of new round of biennium support for the Agency's programme of Technical C-operation (TC). The technical direction of support through these two activities reflects the process that was begun with the external review of the animal production and heath Sub-programme in 1996. Thus in the animal health field this year we have started three new CRPs on rinderpest, contagious bovine pleuropneumonia (CBPP) and Newcastle Disease, and in 1999 we will start a new CRP on developing techniques for separating foot-and-mouth disease (FMD) vaccinated animals from those naturally infected. In the animal production field we will start new CRPs in 1999 on purine derivative analysis in urine, and on tannins whilst in veterinary drug residue analysis the first CRP will commence, again in 1999. Further information on these activities is contained in this Newsletter
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Liu, Fuxiao; Wu, Xiaodong; Li, Lin; Zou, Yanli; Liu, Shan; Wang, Zhiliang
2016-08-01
The genus Morbillivirus is classified into the family Paramyxoviridae, and is composed of 6 members, namely measles virus (MV), rinderpest virus (RPV), peste-des-petits-ruminants virus (PPRV), canine distemper virus (CDV), phocine distemper virus (PDV) and cetacean morbillivirus (CeMV). The MV, RPV, PPRV and CDV have been successfully attenuated through their serial passages in vitro for the production of live vaccines. It has been demonstrated that the morbilliviral virulence in animals was progressively attenuated with their consecutive passages in vitro. However, only a few reports were involved in explanation of an attenuation-related mechanism on them until many years after the establishment of a quasispecies theory. RNA virus quasispecies arise from rapid evolution of viruses with high mutation rate during genomic replication, and play an important role in gradual loss of viral virulence by serial passages. Here, we overviewed the development of live-attenuated vaccine strains against morbilliviruses by consecutive passages in vitro, and further discussed a related mechanism concerning the relationship between virulence attenuation and viral evolution. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Animal production and health newsletter. No. 28
Energy Technology Data Exchange (ETDEWEB)
NONE
1998-06-01
As we move into the second half of 1998, it is appropriate to look forward to 1999 which will see the commencement of four new FAO/IAEA Co-ordinated Research Projects (CRP) and the initiation of new round of biennium support for the Agency`s programme of Technical C-operation (TC). The technical direction of support through these two activities reflects the process that was begun with the external review of the animal production and heath Sub-programme in 1996. Thus in the animal health field this year we have started three new CRPs on rinderpest, contagious bovine pleuropneumonia (CBPP) and Newcastle Disease, and in 1999 we will start a new CRP on developing techniques for separating foot-and-mouth disease (FMD) vaccinated animals from those naturally infected. In the animal production field we will start new CRPs in 1999 on purine derivative analysis in urine, and on tannins whilst in veterinary drug residue analysis the first CRP will commence, again in 1999. Further information on these activities is contained in this Newsletter
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Directory of Open Access Journals (Sweden)
Corteyn A
2004-12-01
Full Text Available The results of a serological survey of livestock in Kazakhstan, carried out in 1997–1998, are reported. Serum samples from 958 animals (cattle, sheep and goats were tested for antibodies to foot and mouth disease (FMD, bluetongue (BT, epizootic haemorrhagic disease (EHD, rinderpest (RP and peste des petits ruminants (PPR viruses, and to Brucella spp. We also investigated the vaccination status of livestock and related this to changes in veterinary provision since independence in 1991. For the 2 diseases under official surveillance (FMD and brucellosis our results were similar to official data, although we found significantly higher brucellosis levels in 2 districts and widespread ignorance about FMD vaccination status. The seroprevalence for BT virus was 23%, and seropositive animals were widespread suggesting endemicity, despite the disease not having being previously reported. We found a few seropositives for EHDV and PPRV, which may suggest that these diseases are also present in Kazakhstan. An hierarchical model showed that seroprevalence to FMD and BT viruses were clustered at the farm/village level, rather than at a larger spatial scale. This was unexpected for FMD, which is subject to vaccination policies which vary at the raion (county level.
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Pesti Des Petits ruminants virus infection in animals
Directory of Open Access Journals (Sweden)
Chauhan H.C.
2009-08-01
Full Text Available For centuries morbillivirus infections have had a huge impact on both human beings and animals. Morbilliviruses are highly contagious pathogens that cause some of the most devastating viral diseases of humans and animals world wide. They include measles virus (MV, canine distemper virus (CDV, rinderpest virus (RPV and peste des petits ruminants (PPRV virus. Furthermore, new emerging infectious diseases of morbilliviruses with significant ecological consequences of marine mammals have been discovered in the past decades. Phocid distemper virus (PDV in seals and the cetacean morbillivirus (CMV have been found in dolphins, whales and porpoises. Peste des petits ruminants (PPR is a highly contagious ,infectious , an acute or sub acute viral disease of domestic and wild small ruminants characterized by fever, oculonasal discharges, stomatitis, conjunctivitis, gastroenteritis and pneumonia. Goats are more severely affected than sheep. It is also known as pseudorinderpest of small ruminants, pest of small ruminants, pest of sheep and goats, kata, stomatitis- pneumoentritis syndrome, contagious pustular stomatitis and pneumoentritis complex. It is one of the major notifiable diseases of the World Organization for Animal Health (OIE. [Vet. World 2009; 2(4.000: 150-155
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Borah, B; Deka, P; Sharma, K; Baro, S; Hazarika, A K; Das, C; Garam, G B; Boro, P; Ltu, K
2018-02-01
Foot-and-mouth disease (FMD) is a contagious disease of cloven-hoofed animals that causes substantial and perpetual economic loss. Apart from the contagious nature of the disease, the FMD virus can establish in a "carrier state" among all cloven-hoofed animals. The Mithun (Bos frontalis), popularly called the "Cattle of Mountain," is found in the geographically isolated, hilly region of north-east India: Arunachal Pradesh, Nagaland, Manipur and Mizoram. Despite the geographical inaccessibility, infection by FMD virus has emerged as the single most devastating disease among Mithun after the eradication of rinderpest from this region. Samples from outbreaks of FMD in Mithun were analysed by sandwich ELISA, multiplex RT-PCR (MRT-PCR) and liquid-phase blocking enzyme-linked immunosorbent assay and isolated in the BHK-21 cell line. The results indicate the presence of FMDV serotype "O." The sequencing and molecular phylogenies have revealed close relationships in the lineage of type "O" isolates from Bangladesh. The findings will provide useful information for further research and development of a sustainable programme for the progressive control of FMD in the Mithun population. © 2017 Blackwell Verlag GmbH.
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The drought of the 1890s in south-eastern Africa
Pribyl, Kathleen; Nash, David; Klein, Jorgen; Endfield, Georgina
2016-04-01
During the second half of the 1890s south-eastern Africa, from modern day Zimbabwe and Botswana down to South Africa, was hit by a drought driven ecological crisis. Using instrumental observations and previously unexploited documentary records in the form of British administrative sources, reports and letters by various Protestant mission societies and newspapers, the extent, duration and severity of the drought are explored. Generally the period was marked by a delayed onset of the rainy season of several months; rainfall totals dropped and perennial rivers such as the Limpopo dried up. The delay of the rainy season negatively impacted the rain-fed agriculture. Recurrent drought conditions during the rainy season frequently withered the young crops. In the interior of southern Africa, on the border of the Kalahari desert, the drought was more severe and continuous than towards the coast of the Indian Ocean. The prolonged dry conditions furthered the outbreak of locust plagues and cattle disease, which in the 1890s took the disastrous form of Rinderpest. A model is established showing how the drought as the original driver of the crisis, triggered a cascade of responses from harvest failure to famine and finally leading to profound socio-economic change.
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International Nuclear Information System (INIS)
Sato, Hiroki; Masuda, Munemitsu; Miura, Ryuichi; Yoneda, Misako; Kai, Chieko
2006-01-01
Morbilliviruses, which belong to the Mononegavirales, replicate its RNA genome in the cytoplasm of the host cell. However, they also form characteristic intranuclear inclusion bodies, consisting of nucleoprotein (N), in infected cells. To analyze the mechanisms of nucleocytoplasmic transport of N protein, we characterized the nuclear localization (NLS) and nuclear export (NES) signals of canine distemper virus (CDV) N protein by deletion mutation and alanine substitution of the protein. The NLS has a novel leucine/isoleucine-rich motif (TGILISIL) at positions 70-77, whereas the NES is composed of a leucine-rich motif (LLRSLTLF) at positions 4-11. The NLS and NES of the N proteins of other morbilliviruses, that is, measles virus (MV) and rinderpest virus (RPV), were also analyzed. The NLS of CDV-N protein is conserved at the same position in MV-N protein, whereas the NES of MV-N protein is located in the C-terminal region. The NES of RPV-N protein is also located at the same position as CDV-N protein, whereas the NLS motif is present not only at the same locus as CDV-N protein but also at other sites. Interestingly, the nuclear export of all these N proteins appears to proceed via a CRM1-independent pathway
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Lasecka-Dykes, Lidia; Wright, Caroline F.; Di Nardo, Antonello; Logan, Grace; Mioulet, Valerie; Jackson, Terry; Tuthill, Tobias J.; Knowles, Nick J.; King, Donald P.
2018-01-01
Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hooved animals that poses a constant burden on farmers in endemic regions and threatens the livestock industries in disease-free countries. Despite the increased number of publicly available whole genome sequences, FMDV data are biased by the opportunistic nature of sampling. Since whole genomic sequences of Southern African Territories (SAT) are particularly underrepresented, this study sequenced 34 isolates from eastern and southern Africa. Phylogenetic analyses revealed two novel genotypes (that comprised 8/34 of these SAT isolates) which contained unusual 5′ untranslated and non-structural encoding regions. While recombination has occurred between these sequences, phylogeny violation analyses indicated that the high degree of sequence diversity for the novel SAT genotypes has not solely arisen from recombination events. Based on estimates of the timing of ancestral divergence, these data are interpreted as being representative of un-sampled FMDV isolates that have been subjected to geographical isolation within Africa by the effects of the Great African Rinderpest Pandemic (1887–1897), which caused a mass die-out of FMDV-susceptible hosts. These findings demonstrate that further sequencing of African FMDV isolates is likely to reveal more unusual genotypes and will allow for better understanding of natural variability and evolution of FMDV. PMID:29652800
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International Nuclear Information System (INIS)
Duffus, W.P.H.
1984-01-01
The influence of isotope-based techniques on both assessment of immune competence and immune response to pathogens is discussed. Immunodeficiencies acquired as a result of factors like malnutrition and concomitant disease can severely affect not only attempts to intensify and improve production but also successful immune response against important vaccines such as rinderpest and foot-and-mouth disease. Isotope-based techniques, with their accuracy, speed and small sample volume, are ideally suited for assessing immunocompetence. One of the main drawbacks remains antigen purity, an area where research should now be concentrated. Lymphocyte transformation is widely used to assess cell-mediated immuno-competence but techniques to assess biological functions such as phagocytosis and cell-mediated cytotoxicity could more usefully reflect immune status. These latter techniques utilize isotopes such as 3 H, 14 C, 32 P and 125 I. Investigation of specific cell-mediated immune response often requires a labelled target. Suitable isotopes such as 51 Cr, 99 Tcsup(m), 75 Se and 3 H are compared for their capacity to label both mammalian and parasite targets. Suggestions are made on a number of areas of research that might usefully be encouraged and supported in order to improve applied veterinary immunology in tropical countries. (author)
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Animal production and health newsletter. No. 44, July 2006
International Nuclear Information System (INIS)
2006-07-01
Three animal disease issues, amongst others, dominated animal health activities in the world; the near eradication of rinderpest (RP), the continued threat of foot-and-mouth disease (FMD) to national and international trade and the ever spreading avian influenza (AI). The importance of early, rapid and sensitive diagnoses of merging diseases, with special reference to AI, can not be overstated and it has prompted our subprogramme to refocus our activities and efforts. The rapid diagnosis and characterization of AI, particularly with respect to molecular tools, are important to determine whether it is H5N1 or another subtype. It is here that the Joint FAO/IAEA Programme can play a role in supporting the actions of the FAO, World organisation for animal health (OIE), WHO and Member States. The subprogramme can provide technical assistance on (1) which tests and protocols to use, (2) technical and laboratory training, (3) expert missions (nominating relevant expert(s) or to perform expert missions by members of the subprogramme), (4) the analysis of AI samples (as primary diagnosis or as confirmation) utilizing the OIE reference status of our Seibersdorf laboratory (i.e. the analysis of translation products of the virus genome) and (5) the provision of technical quality assurance guidelines and support to ensure quality data and reporting
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Overview and epidemiology of contagious bovine pleuropneumonia in Africa.
Masiga, W N; Domenech, J
1995-09-01
Contagious bovine pleuropneumonia (CBPP) is widespread in Africa and in other regions of the world. This disease is particularly important in the semi-arid, sub-humid and arid zones of tropical Africa, but CBPP incidence seems to be increasing in some parts of East Africa. The epidemiology of CBPP is characterised by the occurrence of sub-acute and symptomless infections, and the persistence of chronic carriers. Spread of the disease is associated with cattle movement. The major obstacles to eradication of CBPP are the difficulties in controlling cattle movement and applying quarantine and slaughter policies. Other difficulties arise due to the absence of a field test for diagnosis, the relatively short duration of post-vaccinal immunity and the lack of data on the economic impact of the disease. The Pan-African Rinderpest Campaign strategy for CBPP control and eradication conforms with national control programmes, which include cost/benefit analysis. It is planned to perform blanket vaccination against the disease for three to five years, depending on the economic situation of each country. Stringent control of cattle movement will complement vaccination campaigns. The eradication phase, including slaughter measures, will be instituted following reduction of CBPP incidence. Regional and international coordination will be instituted to control international cattle movement and harmonise control strategies.
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Multiplex RT-PCR and Automated Microarray for Detection of Eight Bovine Viruses.
Lung, O; Furukawa-Stoffer, T; Burton Hughes, K; Pasick, J; King, D P; Hodko, D
2017-12-01
Microarrays can be a useful tool for pathogen detection as it allow for simultaneous interrogation of the presence of a large number of genetic sequences in a sample. However, conventional microarrays require extensive manual handling and multiple pieces of equipment for printing probes, hybridization, washing and signal detection. In this study, a reverse transcription (RT)-PCR with an accompanying novel automated microarray for simultaneous detection of eight viruses that affect cattle [vesicular stomatitis virus (VSV), bovine viral diarrhoea virus type 1 and type 2, bovine herpesvirus 1, bluetongue virus, malignant catarrhal fever virus, rinderpest virus (RPV) and parapox viruses] is described. The assay accurately identified a panel of 37 strains of the target viruses and identified a mixed infection. No non-specific reactions were observed with a panel of 23 non-target viruses associated with livestock. Vesicular stomatitis virus was detected as early as 2 days post-inoculation in oral swabs from experimentally infected animals. The limit of detection of the microarray assay was as low as 1 TCID 50 /ml for RPV. The novel microarray platform automates the entire post-PCR steps of the assay and integrates electrophoretic-driven capture probe printing in a single user-friendly instrument that allows array layout and assay configuration to be user-customized on-site. © 2016 Her Majesty the Queen in Right of Canada.
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Quarantine, exports and animal disease in Australia 1901-2010.
Turner, Aj
2011-09-01
The Constitution forming the Australian Commonwealth Government on 1 January 1901 provided that animal and animal products imported into and exported from Australia would be under the authority of the national government. By mutual agreement, the Quarantine Act 1908 provided for the states to continue the delivery of services under contract until 1995 when the Commonwealth took back full responsibility for quarantine services. In the 1940s, 50s and 60s there were world pandemics of livestock diseases and Australia ceased the import of many species. By the 1970s, the livestock industries sought relaxation of import restrictions to gain access to diversified genetic stock. By the use of new technologies, many species can now be imported into Australia through tight importation protocols. With the advent of the World Trade Organization and implementation of the Sanitary Phytosanitary Agreement, Australia has developed a risk-based framework to support the development of import conditions for animals and animal products. Australia's 'Acceptable Level of Protection' has been set to provide a low likelihood of disease entry. Being an island continent, Australia can apply strong controls over imports and exports of all commodities and relatively few outbreaks of exotic animal diseases have occurred by breach of quarantine, but the outbreaks of rinderpest in 1923 and equine influenza in 2007 were notable exceptions. © 2011 The Author. Australian Veterinary Journal © 2011 Australian Veterinary Association.
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Directory of Open Access Journals (Sweden)
G. Kalema-Zikusoka
2005-09-01
Full Text Available A survey to determine the prevalence of bovine tuberculosis caused by Mycobacterium bovis and certain other infectious diseases was conducted on 42 free-ranging African buffaloes, (Syncerus caffer from May to June 1997 in the Queen Elizabeth National Park, Uganda. Using the gamma interferon test, exposure to M. bovis was detected in 21.6 % of the buffaloes. One dead buffalo and an emaciated warthog (Phacochoerus aethiopicus that was euthanased, were necropsied; both had miliary granulomas from which M. bovis was isolated. None of the buffaloes sampled in Sector A of the park, which has no cattle interface, tested positive for bovine tuberculosis (BTB exposure. The prevalence and distribution of BTB does not appear to have changed significantly since the 1960s, but this may be due to fluxes in the buffalo population. Serological testing for foot-and-mouth disease (FMD demonstrated positive exposure of 57.1% of the buffaloes sampled, with types A, O and SAT 1-3, which is the first known report of FMD antibodies to A and O types in free ranging African buffaloes. Foot-and-mouth disease virus types SAT 1 and SAT 3 were isolated from buffalo probang samples. Two percent of the buffaloes had been exposed to brucellosis. None of the buffaloes tested had antibodies to rinderpest, leptospirosis or Q fever.
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Pastoralism in the drylands of Latin America: Argentina, Chile, Mexico and Peru.
Grünwaldt, J M; Castellaro, G; Flores, E R; Morales-Nieto, C R; Valdez-Cepeda, R D; Guevera, J C; Grünwaldt, E G
2016-11-01
This article discusses various aspects of pastoralism in the Latin American countries with the largest dryland areas. The topics covered include: social, economic and institutional issues; grasslands and their carrying capacity; production systems and productivity rates; competition for forage resources between domestic livestock and wildlife; and the health status of livestock and wildlife. Most grasslands exhibit some degree of degradation. The percentage of offspring reaching weaning age is low: 47-66% of calves and 40-80% of lambs. Some pastoralists adopt patterns of transhumance. In the main, pastoralists experience a high poverty rate and have poor access to social services. For many pastoralists, wildlife is a source of food and by-products. Argentina, Chile, Mexico and Peru have animal health control agencies, are members of the World Organisation for Animal Health (OIE) and have signed the United Nations Convention to Combat Desertification. Pastoral systems subsist mainly on income unrelated to pastoral farming. The OIE recognises all four countries as free from infection with peste des petits ruminants virus, and from rinderpest and African horse sickness. It is difficult to predict the future of pastoralism in Latin America because the situation differs from country to country. For instance, pastoralism is more important in Peru than in Argentina, where it is a more marginal activity. In the future, lack of promotion and protection policies could lead to a decline in pastoralism or to an adverse environmental impact on drylands.
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Directory of Open Access Journals (Sweden)
K. Gillingwater
2010-05-01
Full Text Available Trypanosoma congolense causes the most economically important animal trypanosomosis in Africa. In South Africa, a rinderpest pandemic of the 1890s removed many host animals, resulting in the near-eradication of most tsetse species. Further suppression was achieved through spraying with dichlorodiphenyltrichloroethane (DDT; however, residual populations of Glossina austeni and G. brevipalpis remained in isolated pockets. A total of 506 of these tsetse flies were captured in the Hluhluwe-iMfolozi Park, the St Lucia Wetland Park and Boomerang commercial farm. The polymerase chain reaction (PCR was used to determine the infection rate and frequency of mixed infections of these flies. Additionally, 473 blood samples were collected from cattle at communal diptanks and a commercial farm in the area and each one examined by the haematocrit centrifugation technique (HCT. Furthermore, buffy coats from these blood samples were spotted onto FTA Elute cards and the DNA extracted from each one tested using 3 separate PCRs. The HCT revealed the presence of trypanosomes in only 6.6 % of the blood samples; by contrast, species-specific PCR detected trypanosome DNA in 50 % of the samples. The species-specific PCR detected trypanosome DNA in 17 % of the tsetse flies, compared with the nested PCR targeting rDNA which detected trypanosome DNA in only 14 % of the samples. Over time, the transmission of Savannah-type T. congolense and Kilifi-type T. congolense as mixed infections could have an impact on disease manifestation in different hosts in the area.
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Directory of Open Access Journals (Sweden)
Reza Pilehchian Langroudi
2015-11-01
Full Text Available Context: The genus Clostridium, which consists of spore-forming anaerobes, can cause different diseases in domestic animals and human and some of them are serious and fatal. According to the increasing economic value of the meat and milk-producing animals, the importance of a certain number of such diseases in Iran is unquestionable. Evidence Acquisition: In Iran, and probably in other Near East countries, much attention was formerly paid to control more serious contagious diseases, such as rinderpest, anthrax, etc. resulting in the negligence of diseases such as enterotoxaemia. The epizootiological position has now changed whereby some of the contagious diseases are eradicated or are being methodically controlled.Now it is time to care about the other problems such as clostridial diseases, which threaten the health of the sheep and cattle. It is impossible to eradicate these infectious microorganisms, since they are normally found in the soil and the intestinal contents of apparently healthy animals. Therefore, it is necessary to resort to vaccination which in some cases has given encouraging results. To avoid the losses from such infections it is necessary to have the best possible vaccination information, methodically and regularity of the susceptible animals. Conclusions: This review refers to the veterinary aspects of the anaerobic clostridial diseases and vaccine development concerning the works carried out in Iran and especially at the Razi Serum and Vaccine Research Institute in the last eight decades.
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Viana, Mafalda; Matthiopoulos, Jason; Halliday, Jo; Packer, Craig; Craft, Meggan E.; Hampson, Katie; Czupryna, Anna; Dobson, Andrew P.; Dubovi, Edward J.; Ernest, Eblate; Fyumagwa, Robert; Hoare, Richard; Hopcraft, J. Grant C.; Horton, Daniel L.; Kaare, Magai T.; Kanellos, Theo; Lankester, Felix; Mentzel, Christine; Mlengeya, Titus; Mzimbiri, Imam; Takahashi, Emi; Willett, Brian; Haydon, Daniel T.; Lembo, Tiziana
2015-01-01
Morbilliviruses cause many diseases of medical and veterinary importance, and although some (e.g., measles and rinderpest) have been controlled successfully, others, such as canine distemper virus (CDV), are a growing concern. A propensity for host-switching has resulted in CDV emergence in new species, including endangered wildlife, posing challenges for controlling disease in multispecies communities. CDV is typically associated with domestic dogs, but little is known about its maintenance and transmission in species-rich areas or about the potential role of domestic dog vaccination as a means of reducing disease threats to wildlife. We address these questions by analyzing a long-term serological dataset of CDV in lions and domestic dogs from Tanzania’s Serengeti ecosystem. Using a Bayesian state–space model, we show that dynamics of CDV have changed considerably over the past three decades. Initially, peaks of CDV infection in dogs preceded those in lions, suggesting that spill-over from dogs was the main driver of infection in wildlife. However, despite dog-to-lion transmission dominating cross-species transmission models, infection peaks in lions became more frequent and asynchronous from those in dogs, suggesting that other wildlife species may play a role in a potentially complex maintenance community. Widespread mass vaccination of domestic dogs reduced the probability of infection in dogs and the size of outbreaks but did not prevent transmission to or peaks of infection in lions. This study demonstrates the complexity of CDV dynamics in natural ecosystems and the value of long-term, large-scale datasets for investigating transmission patterns and evaluating disease control strategies. PMID:25605919
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Viana, Mafalda; Cleaveland, Sarah; Matthiopoulos, Jason; Halliday, Jo; Packer, Craig; Craft, Meggan E; Hampson, Katie; Czupryna, Anna; Dobson, Andrew P; Dubovi, Edward J; Ernest, Eblate; Fyumagwa, Robert; Hoare, Richard; Hopcraft, J Grant C; Horton, Daniel L; Kaare, Magai T; Kanellos, Theo; Lankester, Felix; Mentzel, Christine; Mlengeya, Titus; Mzimbiri, Imam; Takahashi, Emi; Willett, Brian; Haydon, Daniel T; Lembo, Tiziana
2015-02-03
Morbilliviruses cause many diseases of medical and veterinary importance, and although some (e.g., measles and rinderpest) have been controlled successfully, others, such as canine distemper virus (CDV), are a growing concern. A propensity for host-switching has resulted in CDV emergence in new species, including endangered wildlife, posing challenges for controlling disease in multispecies communities. CDV is typically associated with domestic dogs, but little is known about its maintenance and transmission in species-rich areas or about the potential role of domestic dog vaccination as a means of reducing disease threats to wildlife. We address these questions by analyzing a long-term serological dataset of CDV in lions and domestic dogs from Tanzania's Serengeti ecosystem. Using a Bayesian state-space model, we show that dynamics of CDV have changed considerably over the past three decades. Initially, peaks of CDV infection in dogs preceded those in lions, suggesting that spill-over from dogs was the main driver of infection in wildlife. However, despite dog-to-lion transmission dominating cross-species transmission models, infection peaks in lions became more frequent and asynchronous from those in dogs, suggesting that other wildlife species may play a role in a potentially complex maintenance community. Widespread mass vaccination of domestic dogs reduced the probability of infection in dogs and the size of outbreaks but did not prevent transmission to or peaks of infection in lions. This study demonstrates the complexity of CDV dynamics in natural ecosystems and the value of long-term, large-scale datasets for investigating transmission patterns and evaluating disease control strategies.
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Screening of peste des petits ruminants virus in a population of district Khairpur, Pakistan.
Maitlo, A K; Ujan, J A; Ujjan, S A; Ruk, M; Memon, B A; Mahar, A A; Ujjan, A A
2017-09-28
Goats are the Pakistan's fastest growing ruminants, and Pakistan is the third largest goat producer in the world after India and China. Goat meat preference is the main reason for its increased demand. In the country, there are 25 goat breeds and two wild relatives such as Mark and Goats. At present, Pakistan has 53.8 million goats, according to the 2006 GOP report, and their population growth rate was more than 3% per year (37, 23, 22, and 18% of the goat population in Punjab, Sindh, Balochistan, and NWFP, respectively). Peste des petits ruminants virus (PPRV) belongs to the family Paramyxoviridae and is considered to be one of the major constraints on increasing the productivity of goats and sheep in the areas where they exist and become local. It is closely related to cattle and buffalo rinderpest virus, dogs and other wild predator distemper virus, human measles virus, and marine mammalian measles virus. The present study aimed to determine the screening of the PPRV, Capra Hircus Lin. population, in the Khairpur Mirs District, Sindh, Pakistan. We selected 290 goats for serum sample collection and analysis using competitive ELISA kits according to the manufacturer's instructions. Our results showed that 59 (64%) of the 92 clinical cases were positive and 33 (36%) were seronegative. The study concluded that PPR might be more prevalent in the Khairpur District. Furthermore, it is highly recommended to use homologous PPR-attenuated vaccines to prevent lethal virus attacks that control PPR in the country.
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Directory of Open Access Journals (Sweden)
Franklin Riet-Correa
1996-08-01
Full Text Available Revisam-se as doenças que devem ser consideradas no diagnóstico diferencial de febre aftosa. Dentre as doenças vesiculares ou erosivas, descrevem-se os principais aspectos relacionados ao diagnóstico da estomatite vesicular, diarréia viral bovina, febre catarral maligna, infecções por herpesvírus bovino 1 e 5, e uma estomatite ulcerativa associada a parvovírus bovino, que ocorreu no Rio Grande do Sul; língua azul, para a qual tem sido detectados anticorpos em bovinos e ovinos do Rio Grande do Sul; mamilite herpética que ocorre em outros Estados do País;peste bovina, que foi diagnosticada e erradicada no Estado de São Paulo em 1921; estomatite popular; e duas doenças exóticas:exantema vesicular e doença vesicular do suíno.Diseases to be considered in the differential diagnosis of foot-and-mouth disease are reviewed. The main aspects relating to the diagnosis of vesicular stomatitis, bovine virus diarrhea, malignant catarrhal fever, bovine herpesvirus 1 and 5, andem ulcerative stomatitis associated with bovine parvovirus are described. Bluetongue, that probably occurs in Rio Grande do Sul because antibodies to the virus have been detected in cattle and sheep; is refered. Bovine ulcerative mammilitis, reported in other Brazilian States, rinderpest, reported and eradicated in the State of São Paulo in 1921, and popular stomatitis are also cited, and so are two exotic diseases: vesicular exanthema and swine vesicular disease.
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Infectious animal diseases: the wildlife/livestock interface.
Bengis, R G; Kock, R A; Fischer, J
2002-04-01
The long-standing conflict between livestock owners and animal health authorities on the one hand, and wildlife conservationists on the other, is largely based on differing attitudes to controlling diseases of livestock which are associated with wildlife. The authors have attempted to highlight the fact that these disease problems are frequently bi-directional at the wildlife/livestock interface. The different categories of diseases involved are presented. A new dimension being faced by veterinary regulatory authorities is the spectre of emerging sylvatic foci of diseases, such as bovine tuberculosis, bovine brucellosis and possibly rinderpest; these diseases threaten to undermine national and international eradication schemes, which have been implemented and executed with significant success, and at great cost. Conversely, wildlife-based ecotourism world-wide has expanded rapidly over the past decade and is the source of lacking foreign revenue for many developing countries. Traditional subsistence farming is still the largest source of much-needed protein on some continents and this, together with the growth and hunger of historically disadvantaged communities for land, is forcing enterprises and communities with markedly different objectives and land-use practices to operate effectively in close proximity. Some land-users rely exclusively on wildlife, others on livestock and/or agronomy, while yet others need to combine these activities. The net result may be an expansion or intensification of the interface between wildlife and domestic livestock, which will require innovative control strategies that permit differing types of wildlife/livestock interaction, and that do not threaten the land-use options of neighbours, or the ability of a country to market animals and animal products profitably.
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Logan, Nicola; Dundon, William G; Diallo, Adama; Baron, Michael D; James Nyarobi, M; Cleaveland, Sarah; Keyyu, Julius; Fyumagwa, Robert; Hosie, Margaret J; Willett, Brian J
2016-11-11
The measurement of virus-specific neutralising antibodies represents the "gold-standard" for diagnostic serology. For animal morbilliviruses, such as peste des petits ruminants (PPRV) or rinderpest virus (RPV), live virus-based neutralisation tests require high-level biocontainment to prevent the accidental escape of the infectious agents. In this study, we describe the adaptation of a replication-defective vesicular stomatitis virus (VSVΔG) based pseudotyping system for the measurement of neutralising antibodies against animal morbilliviruses. By expressing the haemagglutinin (H) and fusion (F) proteins of PPRV on VSVΔG pseudotypes bearing a luciferase marker gene, neutralising antibody titres could be measured rapidly and with high sensitivity. Serological responses against the four distinct lineages of PPRV could be measured simultaneously and cross-neutralising responses against other morbilliviruses compared. Using this approach, we observed that titres of neutralising antibodies induced by vaccination with live attenuated PPRV were lower than those induced by wild type virus infection and the level of cross-lineage neutralisation varied between vaccinates. By comparing neutralising responses from animals infected with either PPRV or RPV, we found that responses were highest against the homologous virus, indicating that retrospective analyses of serum samples could be used to confirm the nature of the original pathogen to which an animal had been exposed. Accordingly, when screening sera from domestic livestock and wild ruminants in Tanzania, we detected evidence of cross-species infection with PPRV, canine distemper virus (CDV) and a RPV-related bovine morbillivirus, suggesting that exposure to animal morbilliviruses may be more widespread than indicated previously using existing diagnostic techniques. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Morbillivirus receptors and tropism: multiple pathways for infection
Directory of Open Access Journals (Sweden)
Hiroki eSato
2012-03-01
Full Text Available Morbilliviruses, which include measles virus (MeV, canine distemper virus, and rinderpest virus, are among the most important pathogens in their respective hosts and cause severe syndromes. Morbilliviruses are enveloped viruses with 2 envelope proteins, one of which is hemagglutinin (H protein, which plays a role in binding to cellular receptors. During morbillivirus infection, the virus initially targets lymphoid cells and replicates efficiently in the lymph nodes. The principal cellular receptor for morbillivirus is signaling lymphocyte activation molecule (SLAM, also called CD150, which is exclusively expressed on immune cells. This feature reflects the strong lymphoid cell tropism and viral spread in the infected body. Morbillivirus infection, however, affects various tissues in the body, including the lung, kidney, gastrointestinal tract, vascular endothelium, and brain. Thus, other receptors for morbilliviruses in addition to SLAM might exist. Recently, nectin-4 has been identified as a novel epithelial cell receptor for MeV. The expression of nectin-4 is localized to polarized epithelial cells, and this localization supports the notion of cell tropism since MeV also grows well in the epithelial cells of the respiratory tract. Although 2 major receptors for lymphoid and epithelial cells in natural infection have been identified, morbillivirus can still infect many other types of cells with low infectivity, suggesting the existence of inefficient but ubiquitously expressed receptors. We have identified other molecules that are implicated in morbillivirus infection of SLAM-negative cells by alternative mechanisms. These findings indicate that morbillivirus utilizes multiple pathways for establishment of infection. These studies will advance our understanding of morbillivirus tropism and pathogenesis.
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International Nuclear Information System (INIS)
Perera, B.M.A.O.; Abeygunawardena, H.
2000-01-01
The use of nuclear techniques for studies on livestock production in Sri Lanka commenced in the 1970's with the establishment of Radioimmunoassay(RIA) technique for measuring reproductive hormones in the blood and milk of buffaloes, cattle and goats. Progesterone measurement was used in a series of studies to monitor reproductive status of ruminants under small-holder farming conditions in different agro-ecological zones, to identify the major constraints and to test methods for improving fertility. Thereafter, other isotopic techniques were established and used together with conventional methods for studies on nutrition, environmental physiology and disease control. In the early 1980's the nuclear-related technique of Enzyme-linked Immunosorbent Assay (ELISA) was established and applied for studies on the immune response of buffaloes to Toxocara vitulorum infection. Subsequently, ELISA techniques were used for studies on sero-epidomology and control of important viral and bacterial disease of cattle and buffaloes (rotavirus infection, haemorrhagic specticaemia, brucellosis, rinderpest and foot-and-mouth disease). The most recent development has been the use of ELISA for diagnosing viral diseases of poultry. In order to transfer the findings from research to the end-users, a multi disciplinary programme was launched in 1995, with the focus on improving buffalo production. Selected farms in three regions of the country participated in the testing, modification and evaluation of appropriate technology packages aimed at imroving the productivity and health of their animals in a sustainable and economically feasible manner. They were provided assistance to upgrade their operations to the status of farms, which are now serving as demonstration sites and training locations for other farmers (AU)
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International Nuclear Information System (INIS)
Amano, Y.
2011-01-01
after its adoption. Adherence to the Amendment can significantly reduce the risk of nuclear material falling into the wrong hands. I encourage the parties to the Convention to work towards accelerating the entry into force of the Amendment. In the area of nuclear applications, one major success story deserves special mention: the worldwide eradication of the deadly cattle disease rinderpest. Rinderpest is, in fact, the first animal disease ever to be eliminated. This is a momentous achievement which is of enormous economic benefit to many developing countries. The net benefit to Africa alone is estimated at more than one billion US dollars per year. Together with the FAO, the World Organisation for Animal Health, the African Union and other partners, the IAEA played an important part in eliminating this highly contagious viral disease. Our role included making available affordable diagnostic techniques and training veterinary staff. The same technologies used to eliminate rinderpest are now being successfully applied to diagnose and control other transboundary animal diseases. In Mongolia for example, the Agency assisted in the successful control of a devastating outbreak of foot-and-mouth disease that threatened the entire livestock population of about 50 million animals. The Agency has paid special attention this year to nuclear techniques related to water. This was the subject of our annual Scientific Forum in September, which was attended by leading scientists and government officials. Nearly a billion people lack access to adequate drinking water. The Agency can help countries to undertake comprehensive assessments of water resources by making available unique information provided through the techniques of isotope hydrology. I will say more about this in a moment. In September, we celebrated the 50th anniversary of the IAEA Environment Laboratories in Monaco.
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International Nuclear Information System (INIS)
2002-01-01
FAO/IAEA support in the area of animal health is focused on enhancing the ability of regional reference laboratories and national veterinary authorities in developing countries to diagnose livestock diseases of major importance using nuclear and related technologies, and to help monitor the effectiveness of national and regional intervention strategies. This is done through provision of advice to the veterinary authorities concerning the development of appropriate sampling or research strategies coupled with FAO/IAEA-led collaborative development, adaptation, standardization, evaluation, and provision of quality-controlled enzyme-linked immunosorbent assay (ELISA) kits and the components necessary for diagnostic application of the polymerase chain reaction (PCR) techniques. Additional features of FAO/IAEA animal health support include provision of relevant laboratory equipment, training of counterpart scientists and technicians in the use of the equipment and standardized assays, and coordination of quality assurance (QA) programmes to monitor the proficiency of the assayists and help evaluate the impact of improved diagnostic capabilities. The current FAO/IAEA External Quality Assurance Programme (EQAP) for Animal Disease Diagnosis began as an effort to monitor the efficacy of mass vaccination programmes as part of the Pan African Rinderpest Campaign (PARC). Proficiency test panels, composed of 40 'unknown' serum samples, were sent to participating laboratories yearly to measure their abilities with ELISA in distinguishing between samples that were positive or negative for rinderpest antibodies. From this beginning, the EQAP has grown into an effort to measure general and specific components of FAO/IAEA counterparts' QA systems and provide assurance to outside observers that the use of FAO/IAEA diagnostic ELISA's are within established control limits and the test results and diagnostic interpretations are reliable. A major objective of the current EQAP is to
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Bodjo, Sanne Charles; Baziki, Jean-de-Dieu; Nwankpa, Nick; Chitsungo, Ethel; Koffi, Yao Mathurin; Couacy-Hymann, Emmanuel; Diop, Mariame; Gizaw, Daniel; Tajelser, Idris Badri Adam; Lelenta, Mamadou; Diallo, Adama; Tounkara, Karim
2018-07-01
Peste des petits ruminants (PPR) is a contagious and economically important disease affecting production of small ruminants (i.e., sheep and goats). Taking into consideration the lessons learnt from the Global Rinderpest Eradication Programme (GREP), PPR is now targeted by the international veterinary community as the next animal disease to be eradicated. To support the African continental programme for the control of PPR, the Pan African Veterinary Vaccine Centre of the African Union (AU-PANVAC) is developing diagnostics tools. Here, we describe the development of a blocking enzyme-linked immunosorbent assay (bELISA) that allows testing of a large number of samples for specific detection of antibodies directed against PPR virus in sheep and goat sera. The PPR bELISA uses an anti-haemagglutinin (H) monoclonal antibody (MAb) as a competitor antibody, and tests results are interpreted using the percentage of inhibition (PI) of MAb binding generated by the serum sample. PI values below or equal to 18% (PI ≤ 18%) are negative, PI values greater than or equal to 25% (PI ≥ 25%) are positive, and PI values greater than 18% and below 25% are doubtful. The diagnostic specificity (DSp) and diagnostic sensitivity (DSe) were found to be 100% and 93.74%, respectively. The H-based PPR-bELISA showed good correlation with the virus neutralization test (VNT), the gold standard test, with a kappa value of 0.947. The H-based PPR-bELISA is more specific than the commercial kit ID Screen® PPR Competition (N-based PPR-cELISA) from IDvet (France), but the commercial kit is slightly more sensitive than the H-based PPR-bELISA. The validation process also indicated good repeatability and reproducibility of the H-based PPR-bELISA, making this new test a suitable tool for the surveillance and sero-monitoring of the vaccination campaign.
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A brief overview of the history of veterinary field services in South Africa
Directory of Open Access Journals (Sweden)
Gideon K. Brückner
2014-11-01
Full Text Available The historical evolution of veterinary services in South Africa is closely linked to the colonial history of the past and the eventual political formation of the Union of South Africa in 1910, as well as the establishment of a fully democratic South Africa in 1994. The majority of the early pioneering veterinarians had close links to military activities and were originally mostly of British origin. The appointment of the first colonial chief veterinary officers occurred in the late 1800s. These appointments were dictated by the need to combat devastating animal diseases, such as rinderpest and African horse sickness, mainly because they affected draught oxen (used for travel and horses (used in combat. Veterinary field services was established in 1962 as a separate functional entity within government services when M.C. Lambrechts became Director of Veterinary Services of South Africa. In the context of this article, veterinary field services refers to that sphere of veterinary service delivery conducted by government-appointed or seconded veterinarians applying disease control and prevention, as required by animal health legislation. Paging through the history of veterinary field services in South Africa confirms that the problems faced by the veterinary services of today were just as real during the times of our pioneers. The pioneers of veterinary services transformed unknown animal diseases into textbook descriptions still used today and also demonstrated the important link to, and use of, the observations made by farmers, as well as the need for continued basic and applied research on animal diseases. This article provided a brief overview of the evolution of veterinary field services and the important role played by pioneers over the last two centuries to make South Africa relatively free and safe from the most important trade-sensitive and economically important animal diseases.
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International Nuclear Information System (INIS)
Egerton, J.R.
2005-01-01
For vaccine production, recombinant antigens must be protective. Identifying protective antigens or candidate antigens is an essential precursor to vaccine development. Even when a protective antigen has been identified, cloning of its gene does not lead directly to vaccine development. The fimbrial protein of Dichelobacter nodosus, the agent of foot-rot in ruminants, was known to be protective. Recombinant vaccines against this infection are ineffective if expressed protein subunits are not assembled as mature fimbriae. Antigenic competition between different, but closely related, recombinant antigens limited the use of multivalent vaccines based on this technology. Recombinant antigens may need adjuvants to enhance response. DNA vaccines, potentiated with genes for different cytokines, may replace the need for aggressive adjuvants, and especially where cellular immunity is essential for protection. The expression of antigens from animal pathogens in plants and the demonstration of some immunity to a disease like rinderpest after ingestion of these, suggests an alternative approach to vaccination by injection. Research on disease pathogenesis and the identification of candidate antigens is specific to the disease agent. The definition of expression systems and the formulation of a vaccine for each disease must be followed by research to establish safety and efficacy. Where vaccines are based on unique gene sequences, the intellectual property is likely to be protected by patent. Organizations, licensed to produce recombinant vaccines, expect to recover their costs and to make a profit. The consequence is that genetically-derived vaccines are expensive. The capacity of vaccines to help animal owners of poorer countries depends not only on quality and cost but also on the veterinary infrastructure where they are used. Ensuring the existence of an effective animal health infrastructure in developing countries is as great a challenge for the developed world as
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Nuclear technology for a sustainable future
International Nuclear Information System (INIS)
2012-06-01
The IAEA helps its Member States to use nuclear technology for a broad range of applications, from generating electricity to increasing food production, from fighting cancer to managing fresh water resources and protecting the world's seas and oceans. Despite the Fukushima Daiichi accident in March 2011, nuclear power will remain an important option for many countries. Use of nuclear power will continue to grow in the next few decades, although growth will be slower than was anticipated before the accident. The factors contributing to the continuing interest in nuclear power include increasing global demand for energy, as well as concerns about climate change, volatile fossil fuel prices and security of energy supply. It will be difficult for the world to achieve the twin goals of ensuring sustainable energy supplies and curbing greenhouse gases without nuclear power. It is up to each country to choose its optimal energy mix. The IAEA helps countries which opt for nuclear power to use it safely and securely. Every day, millions of people throughout the world benefit from the use of nuclear technology. The IAEA helps to make these benefits available to developing countries through its extensive Technical Cooperation programme. For instance, we provide assistance in areas such as human health (through our Programme of Action for Cancer Therapy), animal health (we were active partners in the successful global campaign to eradicate the deadly cattle disease rinderpest), food, water and the environment. The IAEA contributes to the development of global policies to address the energy, food, water and environmental challenges the world faces. We look forward to helping to make Rio+20 a success. This brochure provides an overview of the many ways in which nuclear technology is contributing to building the future we want.
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Domenech, J; Lubroth, J; Eddi, C; Martin, V; Roger, F
2006-10-01
Transboundary animal diseases pose a serious risk to the world animal agriculture and food security and jeopardize international trade. The world has been facing devastating economic losses from major outbreaks of transboundary animal diseases (TADs) such as foot-and-mouth disease, classical swine fever, rinderpest, peste des petits ruminants (PPR), and Rift Valley fever. Lately the highly pathogenic avian influenza (HPAI) due to H5N1 virus, has become an international crisis as all regions around the world can be considered at risk. In the past decades, public health authorities within industrialized countries have been faced with an increasing number of food safety issues. The situation is equally serious in developing countries. The globalization of food (and feed) trade, facilitated by the liberalization of world trade, while offering many benefits and opportunities, also represents new risks. The GF-TADs Global Secretariat has carried out several regional consultations for the identification of priority diseases and best ways for their administration, prevention and control. In the questionnaires carried out and through the consultative process, it was noted that globally, FMD was ranked as the first and foremost priority. Rift Valley fever, and today highly pathogenic avian influenza, are defined as major animal diseases which also affect human health. PPR and CBPP, a disease which is particularly serious in Africa and finally, African swine fever (ASF) and classical swine fever (CSF) are also regionally recognised as top priorities on which the Framework is determined to work. The FAO philosophy--shared by the OIE--embraces the need to prevent and control TADs and emerging diseases at their source, which is most of the time in developing countries. Regional and international approaches have to be followed, and the FAO and OIE GF-TADs initiative provides the appropriate concepts and objectives as well as an organizational framework to link international and
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Directory of Open Access Journals (Sweden)
Mary M Melia
Full Text Available Signalling lymphocyte activation molecule (SLAM has been identified as an immune cell receptor for the morbilliviruses, measles (MV, canine distemper (CDV, rinderpest and peste des petits ruminants (PPRV viruses, while CD46 is a receptor for vaccine strains of MV. More recently poliovirus like receptor 4 (PVRL4, also known as nectin 4, has been identified as a receptor for MV, CDV and PPRV on the basolateral surface of polarised epithelial cells. PVRL4 is also up-regulated by MV in human brain endothelial cells. Utilisation of PVRL4 as a receptor by phocine distemper virus (PDV remains to be demonstrated as well as confirmation of use of SLAM. We have observed that unlike wild type (wt MV or wtCDV, wtPDV strains replicate in African green monkey kidney Vero cells without prior adaptation, suggesting the use of a further receptor. We therefore examined candidate molecules, glycosaminoglycans (GAG and the tetraspan proteins, integrin β and the membrane bound form of heparin binding epithelial growth factor (proHB-EGF,for receptor usage by wtPDV in Vero cells. We show that wtPDV replicates in Chinese hamster ovary (CHO cells expressing SLAM and PVRL4. Similar wtPDV titres are produced in Vero and VeroSLAM cells but more limited fusion occurs in the latter. Infection of Vero cells was not inhibited by anti-CD46 antibody. Removal/disruption of GAG decreased fusion but not the titre of virus. Treatment with anti-integrin β antibody increased rather than decreased infection of Vero cells by wtPDV. However, infection was inhibited by antibody to HB-EGF and the virus replicated in CHO-proHB-EGF cells, indicating use of this molecule as a receptor. Common use of SLAM and PVRL4 by morbilliviruses increases the possibility of cross-species infection. Lack of a requirement for wtPDV adaptation to Vero cells raises the possibility of usage of proHB-EGF as a receptor in vivo but requires further investigation.
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50 Years of Successful Partnership: The Joint FAO/IAEA Division
International Nuclear Information System (INIS)
Dixit, Aabha
2014-01-01
October 2014 will mark the long lasting 50 years of partnership between the Food and Agriculture Organization of the United Nations (FAO) and its partner in the UN system, the IAEA. Established in 1964, the objective of the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture was to use the talents and resources of both organizations to broaden cooperation between their member countries in applying nuclear technology and related bio technologies to develop improved strategies for sustainable agricultural development and food security. From research laboratories to global agrarian systems, nuclear techniques play a vital and distinct role in agricultural research and advancement. They are used in a wide range of applications, from food preservation to crop production and from soil management to animal disease control. The collaborative work of the Joint Division has over the years helped countries solve practical, as well as costly, problems in a variety of areas. The work addresses the application of isotopes and radiation technology in areas such as soil fertility, irrigation, and crop production; plant breeding and genetics; animal production and health; insect and pest control; the control of food contaminants and other food safety issues; and food preservation. These activities are conceived, planned and executed only once they have been reviewed and endorsed by the IAEA’s and FAO’s governing bodies. The joint partnership has witnessed numerous successes, which if not addressed would have had disastrous worldwide implications. These successes include: • Global freedom from rinderpest • The use of mutation induction to develop crop varieties with resistance to the wheat rust disease Ug99 • The eradication of the tsetse fly in Zanzibar Island, Tanzania • The establishment of the regional analytical laboratory network for food safety • Water-saving agriculture in seven African countries For almost five decades, the activities
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The impact of new technologies on vaccines.
Talwar, G P; Diwan, M; Razvi, F; Malhotra, R
1999-01-01
Vast changes are taking place in vaccinology consequent to the introduction of new technologies. Amongst the vaccines included in the Expanded Programme of Immunization (EPI), the pertussis vaccine has been replaced by acellular purified fractions devoid of side-effects. Non-pathogenic but immunogenic mutants of tetanus and diptheria toxins are likely to replace the toxoids. An effective vaccine against hepatitis B prepared by recombinant technology is in large-scale use. Conjugated vaccines against Haemophilus influenzae b, S. pneumococcus and meningococcus are now available, as also vaccines against mumps, rubella and measles. Combination vaccines have been devised to limit the number of injections. Vaccine delivery systems have been developed to deliver multiple doses of the vaccine at a single contact point. A genetically-engineered oral vaccine for typhoid imparts better and longer duration of immunity. Oral vaccines for cholera and other enteric infections are under clinical trials. The nose as a route for immunization is showing promise for mucosal immunity and for anti-inflammatory experimental vaccines against multiple sclerosis and insulin-dependent diabetes mellitus. The range of vaccines has expanded to include pathogens resident in the body such as Helicobacter pylori (duodenal ulcer), S. mutans (dental caries), and human papilloma virus (carcinoma of the cervix). An important progress is the recognition that DNA alone can constitute the vaccines, inducing both humoral and cell-mediated immune responses. A large number of DNA vaccines have been made and shown interesting results in experimental animals. Live recombinant vaccines against rabies and rinderpest have proven to be highly effective for controlling these infections in the field, and those for AIDS are under clinical trial. Potent adjuvants have added to the efficacy of the vaccines. New technologies have emerged to 'humanize' mouse monoclonals by genetic engineering and express these
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Technical Cooperation Report for 2004. Report by the Director General
International Nuclear Information System (INIS)
2005-08-01
The Technical Cooperation Report for 2004 highlights activities and achievements of the technical cooperation programme for the past year. During 2004, the Secretariat finalized the technical cooperation programme for the 2005-2006 biennium, which was approved by the Board of Governors in November 2004. A revised project appraisal process was carried out for the 2005-2006 programme, which yielded additional information regarding government commitment, national capabilities and project performance indicators and outcomes. Included in the 2005-2006 biennium is a strengthened programme for upgrading radiation protection infrastructure. The Secretariat used the experience of the past ten years, as well as conclusions from evaluations, to create a programme that would build upon the successes and lessons learned to provide the safe use of nuclear technology with well-regulated infrastructures. Activities carried out in 2004 built upon previous achievements through national and regional projects in many thematic areas. The programme continued to reinforce the capacity for cancer diagnosis and therapy by providing training and expertise and supporting the procurement of equipment. Consistent support for surveillance techniques using nuclear technology is helping to fight trans-boundary animal diseases, and is leading to countries becoming rinderpest-free. The Secretariat continued to provide expertise and support to assist with the repatriation of highly enriched uranium reactor fuel to the country of origin. The development of partnerships with other United Nations organizations, as well as non-governmental organizations, continues to be of great importance to the technical cooperation programme. In 2004, for example, a memorandum of understanding was signed with the Regional Office for Africa (AFRO) of the World Health Organization (WHO) to support the improvement of health conditions and to raise standards of health in the region. Extrabudgetary resources reached more
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Technical Cooperation Report for 2004. Report by the Director General
International Nuclear Information System (INIS)
2005-08-01
The Technical Cooperation Report for 2004 highlights activities and achievements of the technical cooperation programme for the past year. During 2004, the Secretariat finalized the technical cooperation programme for the 2005-2006 biennium, which was approved by the Board of Governors in November 2004. A revised project appraisal process was carried out for the 2005-2006 programme, which yielded additional information regarding government commitment, national capabilities and project performance indicators and outcomes. Included in the 2005-2006 biennium is a strengthened programme for upgrading radiation protection infrastructure. The Secretariat used the experience of the past ten years, as well as conclusions from evaluations, to create a programme that would build upon the successes and lessons learned to provide the safe use of nuclear technology with well-regulated infrastructures. Activities carried out in 2004 built upon previous achievements through national and regional projects in many thematic areas. The programme continued to reinforce the capacity for cancer diagnosis and therapy by providing training and expertise and supporting the procurement of equipment. Consistent support for surveillance techniques using nuclear technology is helping to fight trans-boundary animal diseases, and is leading to countries becoming rinderpest-free. The Secretariat continued to provide expertise and support to assist with the repatriation of highly enriched uranium reactor fuel to the country of origin. The development of partnerships with other United Nations organizations, as well as non-governmental organizations, continues to be of great importance to the technical cooperation programme. In 2004, for example, a memorandum of understanding was signed with the Regional Office for Africa (AFRO) of the World Health Organization (WHO) to support the improvement of health conditions and to raise standards of health in the region. Extrabudgetary resources reached more
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Technical Cooperation Report for 2004. Report by the Director General
International Nuclear Information System (INIS)
2005-08-01
The Technical Cooperation Report for 2004 highlights activities and achievements of the technical cooperation programme for the past year. During 2004, the Secretariat finalized the technical cooperation programme for the 2005-2006 biennium, which was approved by the Board of Governors in November 2004. A revised project appraisal process was carried out for the 2005-2006 programme, which yielded additional information regarding government commitment, national capabilities and project performance indicators and outcomes. Included in the 2005-2006 biennium is a strengthened programme for upgrading radiation protection infrastructure. The Secretariat used the experience of the past ten years, as well as conclusions from evaluations, to create a programme that would build upon the successes and lessons learned to provide the safe use of nuclear technology with well-regulated infrastructures. Activities carried out in 2004 built upon previous achievements through national and regional projects in many thematic areas. The programme continued to reinforce the capacity for cancer diagnosis and therapy by providing training and expertise and supporting the procurement of equipment. Consistent support for surveillance techniques using nuclear technology is helping to fight trans-boundary animal diseases, and is leading to countries becoming rinderpest-free. The Secretariat continued to provide expertise and support to assist with the repatriation of highly enriched uranium reactor fuel to the country of origin. The development of partnerships with other United Nations organizations, as well as non-governmental organizations, continues to be of great importance to the technical cooperation programme. In 2004, for example, a memorandum of understanding was signed with the Regional Office for Africa (AFRO) of the World Health Organization (WHO) to support the improvement of health conditions and to raise standards of health in the region. Extrabudgetary resources reached more
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Technical Cooperation Report for 2004. Report by the Director General
International Nuclear Information System (INIS)
2005-07-01
The Technical Cooperation Report for 2004 highlights activities and achievements of the technical cooperation programme for the past year. During 2004, the Secretariat finalized the technical cooperation programme for the 2005-2006 biennium, which was approved by the Board of Governors in November 2004. A revised project appraisal process was carried out for the 2005-2006 programme, which yielded additional information regarding government commitment, national capabilities and project performance indicators and outcomes. Included in the 2005-2006 biennium is a strengthened programme for upgrading radiation protection infrastructure. The Secretariat used the experience of the past ten years, as well as conclusions from evaluations, to create a programme that would build upon the successes and lessons learned to provide the safe use of nuclear technology with well-regulated infrastructures. Activities carried out in 2004 built upon previous achievements through national and regional projects in many thematic areas. The programme continued to reinforce the capacity for cancer diagnosis and therapy by providing training and expertise and supporting the procurement of equipment. Consistent support for surveillance techniques using nuclear technology is helping to fight trans-boundary animal diseases, and is leading to countries becoming rinderpest-free. The Secretariat continued to provide expertise and support to assist with the repatriation of highly enriched uranium reactor fuel to the country of origin. The development of partnerships with other United Nations organizations, as well as non-governmental organizations, continues to be of great importance to the technical cooperation programme. In 2004, for example, a memorandum of understanding was signed with the Regional Office for Africa (AFRO) of the World Health Organization (WHO) to support the improvement of health conditions and to raise standards of health in the region. Extrabudgetary resources reached more
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Technical Cooperation Report for 2004. Report by the Director General
Energy Technology Data Exchange (ETDEWEB)
NONE
2005-07-15
The Technical Cooperation Report for 2004 highlights activities and achievements of the technical cooperation programme for the past year. During 2004, the Secretariat finalized the technical cooperation programme for the 2005-2006 biennium, which was approved by the Board of Governors in November 2004. A revised project appraisal process was carried out for the 2005-2006 programme, which yielded additional information regarding government commitment, national capabilities and project performance indicators and outcomes. Included in the 2005-2006 biennium is a strengthened programme for upgrading radiation protection infrastructure. The Secretariat used the experience of the past ten years, as well as conclusions from evaluations, to create a programme that would build upon the successes and lessons learned to provide the safe use of nuclear technology with well-regulated infrastructures. Activities carried out in 2004 built upon previous achievements through national and regional projects in many thematic areas. The programme continued to reinforce the capacity for cancer diagnosis and therapy by providing training and expertise and supporting the procurement of equipment. Consistent support for surveillance techniques using nuclear technology is helping to fight trans-boundary animal diseases, and is leading to countries becoming rinderpest-free. The Secretariat continued to provide expertise and support to assist with the repatriation of highly enriched uranium reactor fuel to the country of origin. The development of partnerships with other United Nations organizations, as well as non-governmental organizations, continues to be of great importance to the technical cooperation programme. In 2004, for example, a memorandum of understanding was signed with the Regional Office for Africa (AFRO) of the World Health Organization (WHO) to support the improvement of health conditions and to raise standards of health in the region. Extrabudgetary resources reached more
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Technical Cooperation Report for 2004. Report by the Director General
International Nuclear Information System (INIS)
2005-08-01
The Technical Cooperation Report for 2004 highlights activities and achievements of the technical cooperation programme for the past year. During 2004, the Secretariat finalized the technical cooperation programme for the 2005-2006 biennium, which was approved by the Board of Governors in November 2004. A revised project appraisal process was carried out for the 2005-2006 programme, which yielded additional information regarding government commitment, national capabilities and project performance indicators and outcomes. Included in the 2005-2006 biennium is a strengthened programme for upgrading radiation protection infrastructure. The Secretariat used the experience of the past ten years, as well as conclusions from evaluations, to create a programme that would build upon the successes and lessons learned to provide the safe use of nuclear technology with well-regulated infrastructures. Activities carried out in 2004 built upon previous achievements through national and regional projects in many thematic areas. The programme continued to reinforce the capacity for cancer diagnosis and therapy by providing training and expertise and supporting the procurement of equipment. Consistent support for surveillance techniques using nuclear technology is helping to fight trans-boundary animal diseases, and is leading to countries becoming rinderpest-free. The Secretariat continued to provide expertise and support to assist with the repatriation of highly enriched uranium reactor fuel to the country of origin. The development of partnerships with other United Nations organizations, as well as non-governmental organizations, continues to be of great importance to the technical cooperation programme. In 2004, for example, a memorandum of understanding was signed with the Regional Office for Africa (AFRO) of the World Health Organization (WHO) to support the improvement of health conditions and to raise standards of health in the region. Extrabudgetary resources reached more
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Peste des petits ruminants (PPR: A Serious Threat for Wild Life
Directory of Open Access Journals (Sweden)
Hamed Ebrahimzadeh Leylabadlo
2016-04-01
Full Text Available Introduction Peste des petits ruminants (PPR is the most contagious and extremely infectious respiratory diseases in goats and sheep and is most common in West and Central Africa, Middle East and Southern Asia; it spreads rapidly regardless of country borders (1. A serological and virological outbreak of PPR was identified in Ilam province, Iran near the Iraqi border in 1995. Since then, despite all control measures, numerous incidents of the disease have been reported throughout the country (2. Between 1995 and 2004, vaccination of sheep and goats was performed by cell cultured rinderpest (RP vaccine; the small ruminants started to be vaccinated from early 2005 (2. In spite of vaccination of susceptible animals and application of some containment measures, PPR spread through the whole country, infecting every province with fluctuating prevalence and continuity. The cause of this failure might be related to the fact that well-designed control program in the country was not carried out appropriately and vaccination schedule was not covered abundantly. For instance in 2011, just over 3.5 million small ruminants received vaccine from an estimated National population of just fewer than 80 million animals (3. Some species of animal , e.g. such as gazelles, goats and sheep, that are relatively prevalent in Middle Eastern countries especially in Iran are believed to be immune to PPR infection (4. The wildlife in Iran consists of several animal species that include bears, gazelles, foxes, and also domestic animals including sheep, goats, cattle, and camels. It is believed that PPR virus circulates in domestic ruminants and acts as a potential source of virus for wild animal species in wildlife and the role of domestic small ruminants in the spread of the disease to wild ruminants is clear. It is quite possible that in cases of pastures exchange between domestic and wild animals, the spread of PPR is facilitated between the two populations (5. In Iran
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IAEA to Help West African Countries Diagnose Ebola
International Nuclear Information System (INIS)
2014-01-01
and acquire equipment they need to use RT-PCR for diagnosis of animal diseases and zoonotic diseases. The method was instrumental in the global eradication of rinderpest, long a scourge of livestock. ''Transfer of nuclear-related technologies is a key part of the Agency's work, and we have cooperated with Member States for years to develop and strengthen their capacity to use this nuclear-derived technology,'' Director General Amano said. ''With this additional support, the Agency makes a small but effective contribution to global efforts to fight the ongoing Ebola outbreak.'' RT-PCR initially used radioactive isotopes as markers in the process that determines whether the virus is present in a sample. Subsequent refining of the method by the IAEA and partners has led to the possibility to use fluorescent markers instead of radioactive markers for screening purposes. The IAEA will provide Sierra Leone with an RT-PCR machine, cooling systems, biosecurity equipment, diagnostic kits and other materials. Similar support will eventually be provided to Liberia and Guinea. The IAEA also is developing an African regional project that would strengthen Member States' capacity to monitor wildlife and livestock to get early warning of possible zoonotic disease outbreaks in the medium- and longer-term. (IAEA)
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Directory of Open Access Journals (Sweden)
Dossou, J.
2007-01-01
Full Text Available Physico-chemical and Sensorial Evaluation of Local Tomato Past Produced at Small Scale in Benin. L'article fait le point sur les avancements notés dans l'éradication de la peste bovine en Afrique sub-saharienne, avec à l'horizon 2010, l'éradication mondiale de la peste, telle que prévu par le Global Rinderpest Eradication Programme (GREP. Le programme Pan-Africain de Contrôle des Epizooties (PACE, un programme exécuté depuis 1999 sous l'égide de l'Union Africaine (UA avec le concours financier du Fonds Européen pour le Développement (UE, exécute actuellement la dernière phase de ce programme d'éradication. Les auteurs passent en revue l'historique, le diagnostic et les outils de contrôle de cette maladie, tant chez le bétail que chez la faune. A l'heure actuelle, il ne reste qu'une partie de l'Afrique de l'est où sévit la maladie. Cependant aucun foyer n'y a été signalé depuis 2001. La seule lignée encore rencontrée (lignée 2 africaine se cantonne à l'écosystème somalien, qui regroupe la Somalie, l'est du Kenya et la 5ième région de l'Ethiopie. Réapparue en 1994, 1998, et 2001 dans la faune sauvage, cette lignée représente donc la cible des derniers efforts d'éradication. En dehors de cette zone, la peste bovine semblerait être absente de l'Afrique de l'est. En Afrique de l'ouest et du centre où la maladie est absente depuis des décennies, les activités sont axées sur la certification internationale (par l'Organisation Mondiale de la Santé Animale, OIE de l'absence de la maladie et de l'infection. Sur les 30 pays que couvre le PACE, 12 pays ont obtenu à ce jour le statut 'indemne de l'infection': Bénin, Burkina Faso, Burundi, Congo, Erythrée, Guinée, Guinée Bissau, Mali, RDC, Rwanda, Sénégal et Togo. Onze pays enfin, la Côte d'Ivoire, l'Ethiopie, le Ghana, le Kenya, la Mauritanie, le Niger, le Nigeria, l'Ouganda, le Soudan, la Tanzanie et le Tchad ont été déclarés 'indemnes de maladie' (en ce
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Energy Technology Data Exchange (ETDEWEB)
Smith, S; Danganan, L; Tammero, L; Lenhoff, R; Naraghi-arani, P; Hindson, B
2007-08-06
Lawrence Livermore National Laboratory (LLNL), in collaboration with the Department of Homeland Security (DHS) and the United States Department of Agriculture (USDA), Animal and Plant Health Inspection Services (APHIS) has developed advanced rapid diagnostics that may be used within the National Animal Health Laboratory Network (NAHLN), the National Veterinary Services Laboratory (Ames, Iowa) and the Plum Island Animal Disease Center (PIADC). This effort has the potential to improve our nation's ability to discriminate between foreign animal diseases and those that are endemic using a single assay, thereby increasing our ability to protect animal populations of high economic importance in the United States. Under 2005 DHS funding we have developed multiplexed (MUX) nucleic-acid-based PCR assays that combine foot-and-mouth disease virus (FMDV) detection with rule-out tests for two other foreign animal diseases Vesicular Exanthema of Swine (VESV) and Swine Vesicular Disease (SVD) and four other domestic viral diseases Bovine Viral Diarrhea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1 or Infectious Bovine Rhinotracheitus IBR), Bluetongue virus (BTV) and Parapox virus complex (which includes Bovine Papular Stomatitis Virus BPSV, Orf of sheep, and Pseudocowpox). Under 2006 funding we have developed a Multiplexed PCR [MUX] porcine assay for detection of FMDV with rule out tests for VESV and SVD foreign animal diseases in addition to one other domestic vesicular animal disease vesicular stomatitis virus (VSV) and one domestic animal disease of swine porcine reproductive and respiratory syndrome (PRRS). We have also developed a MUX bovine assay for detection of FMDV with rule out tests for the two bovine foreign animal diseases malignant catarrhal fever (MCF), rinderpest virus (RPV) and the domestic diseases vesicular stomatitis virus (VSV), bovine viral diarrhea virus (BVDV), infectious bovine rhinotracheitus virus (BHV-1), bluetongue virus (BTV), and the Parapox
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Nuclear Technologies Secure Food For Future
International Nuclear Information System (INIS)
2012-01-01
Full text: For nearly fifty years, applications of nuclear technology have been helping the world's farmers, contributing new varieties of crops, controlling pests, diagnosing livestock disease, improving soil and water management and increasing food safety. The significant role of nuclear technology in supporting agriculture will be the focus of this year's IAEA Scientific Forum in Vienna on 18-19 September. Food for the Future: Meeting the Challenges with Nuclear Applications is the theme of the Forum, which takes place during the annual IAEA General Conference. ''Demand for food is rising significantly as the world's population grows,'' IAEA Director General Yukiya Amano said. ''Fighting hunger is a key priority. It is essential not only that the world should produce more food. We must also protect crops and livestock and make sure that food is safe to eat. Nuclear applications can make a real difference in all of these areas.'' ''The goal of the Scientific Forum is to make Member States more aware of the very important work of the IAEA in nuclear applications related to food and to encourage more countries to make use of our services.'' Nuclear technology has many possible uses in food and agriculture. By irradiation, scientists can accelerate natural spontaneous mutation and improve crop varieties to suit particular conditions. Farmers are benefitting from rice that grows in salty conditions, barley that flourishes above 4 000 metres (13 000 feet) and hundreds of other crop varieties. The use of the sterile insect technique, in which males of a targeted species such as the tsetse fly or the Mediterranean fruit fly are sterilised by radiation and released into the wild, is expanding significantly. This effectively combats insect pests that damage crops and spread disease among humans and livestock, while limiting pesticide use. The world was last year declared free of the deadly cattle disease rinderpest after a campaign made possible by nuclear techniques. The
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2011-01-01
Jean-Marie Blancou was born in Bangui on 28 August 1936 and passed away in Paris on 10 November 2010 at the age of 74. After studying at the Pierre de Fermat Lycée in Toulouse, Jean Blancou graduated from the Toulouse Veterinary School in 1960. He continued his studies in tropical veterinary medicine in Paris until 1963, extending his knowledge of immunology, microbiology, biochemistry and zoology, at the Institut Pasteur. He obtained his doctorate in biological sciences at the University of Nancy in 1982. Jean Blancou commenced his career as technical adviser to the Veterinary Services of Ethiopia where he directed a campaign against rinderpest in the south of the county. From 1965 to 1967 he was deputy director of the national veterinary laboratory in Niamey where he was responsible for the diagnosis of animal diseases and the production of veterinary vaccines. In 1967, he moved to the central livestock laboratory in Madagascar, where he commenced research on the diagnosis and control of dermatophilosis, bovine tuberculosis and other bacterial and parasitic diseases. In August 1968 he married Geneviève Orue. In 1975 he was appointed as head of the national veterinary laboratory in Senegal, where he remained until 1977. Initially deputy director, and then director of Research on rabies and wildlife diseases, at the World Health Organization collaborating centre in Nancy, he remained in this position until 1990. Jean Blancou was recognised as a world authority on rabies. He conducted research into the diagnosis, aetiology, epidemiology and control of rabies during his time in Nancy. Between 1988 and 1990, Dr Blancou also headed the animal health and protection department of the Centre national d'études vétérinaires et animales (CNEVA) in Maisons-Alfort. On 1 January 1991, he was appointed director general of the World Organisation for Animal Health (Office International des Épizooties: OIE) and was re-elected in 1995 for a further five-year term, until he
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Energy Technology Data Exchange (ETDEWEB)
Smith, S M; Danganan, L; Tammero, L; Vitalis, B; Lenhoff, R; Naraghi-arani, P; Hindson, B
2007-08-06
Lawrence Livermore National Laboratory (LLNL), in collaboration with the Department of Homeland Security (DHS) and the United States Department of Agriculture (USDA), Animal and Plant Health Inspection Services (APHIS) has developed candidate multiplexed assays that may potentially be used within the National Animal Health Laboratory Network (NAHLN), the National Veterinary Services Laboratory (Ames, Iowa) and the Plum Island Animal Disease Center (PIADC). This effort has the ability to improve our nation's capability to discriminate between foreign animal diseases and those that are endemic using a single assay, thereby increasing our ability to protect food and agricultural resources with a diagnostic test which could enhance the nation's capabilities for early detection of a foreign animal disease. In FY2005 with funding from the DHS, LLNL developed the first version (Version 1.0) of a multiplexed (MUX) nucleic-acid-based RT-PCR assay that included signatures for foot-and-mouth disease virus (FMDV) detection with rule-out tests for two other foreign animal diseases (FADs) of swine, Vesicular Exanthema of Swine (VESV) and Swine Vesicular Disease Virus (SVDV), and four other domestic viral diseases Bovine Viral Diarrhea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1), Bluetongue virus (BTV) and Parapox virus complex (which includes Bovine Papular Stomatitis Virus [BPSV], Orf of sheep, and Pseudocowpox). In FY06, LLNL has developed Bovine and Porcine species-specific panel which included existing signatures from Version 1.0 panel as well as new signatures. The MUX RT-PCR porcine assay for detection of FMDV includes the FADs, VESV and SVD in addition to vesicular stomatitis virus (VSV) and porcine reproductive and respiratory syndrome (PRRS). LLNL has also developed a MUX RT-PCR bovine assay for detection of FMDV with rule out tests for the two bovine FADs malignant catarrhal fever (MCF), rinderpest virus (RPV) and the domestic diseases vesicular stomatitis
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Foot & Mouth Disease & Ulcerative/Vesicular Rule-outs: Challenges Encountered in Recent Outbreaks
Energy Technology Data Exchange (ETDEWEB)
Hullinger, P
2008-01-28
development and subsequent rupturing of vesicles at the coronary band and in the oral cavity. Vesicles and ulcerations can also occur on the mammary gland. Recovery in adult animals usually occurs in 8-15 days. Clinical signs for most serotypes are less dramatic in sheep and goats. Swine can develop very severe coronary band lesions and high mortality in piglets has been observed. One of the challenges of diagnosing FMD is that it may be clinically similar to several other vesicular or ulcerative diseases. FMD is clinically indistinguishable from Vesicular stomatitis, Swine vesicular disease and Vesicular exanthema of swine. It may also resemble Bovine viral diarrhea, Mucosal disease, Infectious bovine rhinotracheitis, Bluetongue, Bovine papular stomatitis, Bovine mammillitis and Rinderpest.
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Directory of Open Access Journals (Sweden)
Anon.
2011-01-01
Full Text Available Chevalier de la Légion d’honneurChevalier de l’Ordre national du mérite agricoleCommandeur de l’Ordre national du mérite agricoleCorresponding member of the Argentinean Academy of Agronomy and Veterinary Medicine Docteur honoris causa, Liege University (Belgium Foreign member of the Royal Belgian Academy of Agriculture Foreign member of the Russian Academy of Agronomic Sciences Honorary Director General of the OIEHonorary Member of the British Veterinary AssociationMédaille d’honneur, CNEVAMember and previous President of the French Veterinary Academy Member of the Academy of Sciences of Overseas TerritoriesPrix Trasbot, Académie vétérinaire de France, 1980Vice President of the Société française d’histoire de la médecine et des sciences vétérinairese Jean-Marie Blancou was born in Bangui on 28 August 1936 and passed away in Paris on 10 November 2010 at the age of 74. After studying at the Pierre de Fermat Lycée in Toulouse, Jean Blancou graduated from the Toulouse Veterinary School in 1960. He continued his studies in tropical veterinary medicine in Paris until 1963, extending his knowledge of immunology, microbiology, biochemistry and zoology, at the Institut Pasteur. He obtained his doctorate in biological sciences at the University of Nancy in 1982.Jean Blancou commenced his career as technical adviser to the Veterinary Services of Ethiopia where he directed a campaign against rinderpest in the south of the county. From 1965 to 1967 he was deputy director of the national veterinary laboratory in Niamey where he was responsible for the diagnosis of animal diseases and the production of veterinary vaccines.In 1967, he moved to the central livestock laboratory in Madagascar, where he commenced research on the diagnosis and control of dermatophilosis, bovine tuberculosis and other bacterial and parasitic diseases.In August 1968 he married Geneviève Orue.In 1975 he was appointed as head of the national veterinary
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Nuclear Technology Review 2012
International Nuclear Information System (INIS)
2012-09-01
the supply of enrichment services and LEU for use in NPPs. Furthermore, during 2011 the Secretariat continued work on developing the administrative, financial, legal and technical arrangements for an Agency-coordinated LEU bank to serve as a supply of last resort for nuclear power generation. The Agency accepted an offer from Kazakhstan to host the bank at the Ulba Metallurgical Plant, and formal negotiations on the Host State Agreement began in 2012. In the area of radioactive waste management, the Council of the EU adopted on 19 July 2011 a Directive establishing a Community framework for the responsible and safe management of spent fuel and radioactive waste. This Directive adopted a set of harmonized standards for all EU member countries that are based on the Agency's safety standards. In Sweden, the Swedish nuclear fuel and waste management company SKB submitted a license application to build a final disposal facility for spent nuclear fuel in Forsmark in March 2011. In the USA, the Blue Ribbon Commission on America's Nuclear Future issued, in July 2011, draft recommendations for developing a long-term solution to the management of the USA's spent fuel and nuclear waste. The final report was issued in January 2012. In 2011, the Food and Agriculture Organization of the United Nations and the World Organisation for Animal Health (OIE) declared the global eradication of rinderpest, the most devastating infection of cattle, and for centuries a major cause of famine and poverty. After smallpox in 1980, this is only the second disease that has been successfully eradicated. Nuclear and nuclear-related techniques made an important contribution through the development and use of diagnostic tests such as the enzyme linked immunosorbent assay (ELISA), as developed by the IAEA Animal Production and Health Laboratory.
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Energy Technology Data Exchange (ETDEWEB)
NONE
2005-08-15
The Technical Cooperation Report for 2004 highlights activities and achievements of the technical cooperation programme for the past year. During 2004, the Secretariat finalized the technical cooperation programme for the 2005-2006 biennium, which was approved by the Board of Governors in November 2004. A revised project appraisal process was carried out for the 2005-2006 programme, which yielded additional information regarding government commitment, national capabilities and project performance indicators and outcomes. Included in the 2005-2006 biennium is a strengthened programme for upgrading radiation protection infrastructure. The Secretariat used the experience of the past ten years, as well as conclusions from evaluations, to create a programme that would build upon the successes and lessons learned to provide the safe use of nuclear technology with well-regulated infrastructures. Activities carried out in 2004 built upon previous achievements through national and regional projects in many thematic areas. The programme continued to reinforce the capacity for cancer diagnosis and therapy by providing training and expertise and supporting the procurement of equipment. Consistent support for surveillance techniques using nuclear technology is helping to fight trans-boundary animal diseases, and is leading to countries becoming rinderpest-free. The Secretariat continued to provide expertise and support to assist with the repatriation of highly enriched uranium reactor fuel to the country of origin. The development of partnerships with other United Nations organizations, as well as non-governmental organizations, continues to be of great importance to the technical cooperation programme. In 2004, for example, a memorandum of understanding was signed with the Regional Office for Africa (AFRO) of the World Health Organization (WHO) to support the improvement of health conditions and to raise standards of health in the region. Extrabudgetary resources reached more
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Directory of Open Access Journals (Sweden)
Anon.
2012-09-01
traded safely from Africa and other developing countries and provided a case example for use internationally.He was particularly skilled in the management of infectious diseases (such as foot and mouth disease [FMD] and rinderpest of cattle which can have serious repercussions on national economies and also on the livelihood of small farmers. His observations and knowledge influenced the elaboration of standards for certain diseases, moving them from a ‘risk-free’ approach, often favoured by developed countries, to a more facilitative and sensible ‘risk managed’ approach to support trade and marketing.His dedication to the management of animal health in southern Africa, and in Zimbabwe in particular, was widely recognised. There are few who would approach the breadth and depth of his professional competence, vision and initiative.In Zimbabwe, he dealt with all major animal health problems, including FMD, rabies and anthrax. He was instrumental in the creation of the Tsetse and Trypanosomiasis Control Branch which led to Zimbabwe being recognised as a Centre of Excellence for tsetse fly control in the region. He personally pioneered investigations into the role of FMD carrier cattle in the epidemiology of the disease; the result of his work has had a major impact on FMD control strategies in the region and internationally. He was responsible for taking charge of a massive outbreak of FMD in 1978 that was eventually controlled after the cessation of hostilities in Zimbabwe in 1980. His involvement in the control and eradication of FMD from Mashonaland in this outbreak must rank as outstanding. He was considered an authority on the disease internationally.In Zimbabwe, Dr Hargreaves also had personal responsibility for the design and establishment of wildlife conservancies resulting in land utilisation improvements in arid regions, wildlife health and disease control (thereby also contributing the tourist industry, improvements to legislation, introduction of a