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Sample records for rh maintenance assessment

  1. Concept design on RH maintenance of CFETR Tokamak reactor

    International Nuclear Information System (INIS)

    Song, Yuntao; Wu, Songtao; Wan, Yuanxi; Li, Jiangang; Ye, Minyou; Zheng, Jinxing; Cheng, Yong; Zhao, Wenlong; Wei, Jianghua

    2014-01-01

    Highlights: •We discussed the concept design of the RH maintenance system based on the main design work of the key components for CFETR. •The main design work for RH maintenance in this paper was carried out including the divertor RH system, the blanket RH system and the transfer cask system. •The technical problems encountered in the design process were discussed. •The present concept design of remote maintenance system in this paper can meet the physical and engineering requirement of CFETR. -- Abstract: CFETR which stands for Chinese Fusion Engineering Testing Reactor is a superconducting Tokamak device. The concept design on RH maintenance of CFETR has been done in the past year. It is known that, the RH maintenance is one of the most important parts for Tokamak reactor. The fusion power was designed as 50–200 MW and its duty cycle time (or burning time) was estimated as 30–50%. The center magnetic field strength on the TF magnet is 5.0 T, the maximum capacity of the volt seconds provided by center solenoid winding will be about 160 VS. The plasma current will be 10 MA and its major radius and minor radius is 5.7 m and 1.6 m respectively. All the components of CFETR which provide their basic functions must be maintained and inspected during the reactor lifetime. Thus, the remote handling (RH) maintenance system should be a key component, which must be detailedly designed during the concept design processing of CFETR, for the operation of reactor. The main design work for RH maintenance in this paper was carried out including the divertor RH system, the blanket RH system and the transfer cask system. What is more, the technical problems encountered in the design process will also be discussed

  2. Analysis and validation center for ITER RH maintenance scenarios in a virtual environment

    International Nuclear Information System (INIS)

    Elzendoorn, B.S.Q.; Baar, M. de; Hamilton, D.; Heemskerk, C.J.M.; Koning, J.F.; Ronden, D.M.S.

    2012-01-01

    A facility for detailed simulation of maintenance processes in the ITER Hot Cell Facility (HCF) has been taken into operation. The facility mimics the Remote Handling (RH) work-cells as are presently foreseen. Novel virtual reality (VR) technology, extended with a physics engine is used to create a realistic setting in which a team of Remote Handling (RH) operators can interact with a virtual Hot Cell environment. The physics engine is used to emulate the Hot Cell behavior and to provide tactile feed-back of the (virtual) slave. Multi-operator maintenance scenarios can be developed and tested in virtual reality. Complex interactions between the RH operators and the HCF control system software will be tested. Task performance will be quantified and operational resource consumption will be estimated.

  3. Analysis and validation center for ITER RH maintenance scenarios in a virtual environment

    Energy Technology Data Exchange (ETDEWEB)

    Elzendoorn, B.S.Q., E-mail: B.S.Q.Elzendoorn@rijnhuizen.nl [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, Partner in the Trilateral Euregio Cluster and ITER-NL, PO Box 1207, 3430 BE, Nieuwegein (Netherlands); Baar, M. de [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, Partner in the Trilateral Euregio Cluster and ITER-NL, PO Box 1207, 3430 BE, Nieuwegein (Netherlands); Hamilton, D. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul-lez-Durance Cedex (France); Heemskerk, C.J.M. [Heemskerk Innovative Technology, Sassenheim (Netherlands); Koning, J.F.; Ronden, D.M.S. [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, Partner in the Trilateral Euregio Cluster and ITER-NL, PO Box 1207, 3430 BE, Nieuwegein (Netherlands)

    2012-03-15

    A facility for detailed simulation of maintenance processes in the ITER Hot Cell Facility (HCF) has been taken into operation. The facility mimics the Remote Handling (RH) work-cells as are presently foreseen. Novel virtual reality (VR) technology, extended with a physics engine is used to create a realistic setting in which a team of Remote Handling (RH) operators can interact with a virtual Hot Cell environment. The physics engine is used to emulate the Hot Cell behavior and to provide tactile feed-back of the (virtual) slave. Multi-operator maintenance scenarios can be developed and tested in virtual reality. Complex interactions between the RH operators and the HCF control system software will be tested. Task performance will be quantified and operational resource consumption will be estimated.

  4. Analysis and validation center for ITER RH maintenance scenarios in a virtual environment

    NARCIS (Netherlands)

    Elzendoorn, B. S. Q.; M.R. de Baar,; Hamilton, D.; Heemskerk, C. J. M.; Koning, J. F.; Ronden, D. M. S.

    2012-01-01

    A facility for detailed simulation of maintenance processes in the ITER Hot Cell Facility (HCF) has been taken into operation. The facility mimics the Remote Handling (RH) work-cells as are presently foreseen. Novel virtual reality (VR) technology, extended with a physics engine is used to create a

  5. Maintenance and Outage Management Assessment (MOMA)

    International Nuclear Information System (INIS)

    2005-01-01

    The competitive environment has significant implications for nuclear power plant (NPP) operations, which include, inter alia, the need for efficient use of resources and effective management of plant activities of maintenance and outages. The purpose of NPP maintenance and outages is to allow NPPs to use all those functions necessary for safe and reliable power production by keeping them available and adequate maintenance programme is essential. The maintenance programme covers all preventive and remedial measures, both administrative and technical, necessary to identify and mitigate degradation of a functioning system, structure or component, or restore the design functions of a failed system, structure or component to an acceptable level. In response to the needs of MSs, NPES (Nuclear Power Section, Division of Nuclear Power, IAEA) plans to strengthen its services. NPES services will not only continue to provide its 'traditional' products of publications of nuclear industrial best practices and technical implementation of TC projects on plant maintenance and outage management, but also be expanded to deliver, in a timely manner, technical support missions as requested by MSs for NPPs. One of many services is Maintenance and Outage Management Assessment (MOMA). The NPP can obtain support and assistance in assessment and optimisation of its maintenance program and/or outage management. It aims to help the NPP improve its performance of maintenance and outage in a competitive nuclear power business environment. The specific benefits of the assessment are as follows: a) disseminate nuclear industrial best practices on maintenance program and outage management in the world, b) benchmark, evaluate and optimise the approach of maintenance program and outage management and c) identify solutions to known problems at nuclear power plants, if any. MOMA is conducted at the request of NPPs of any IAEA Member States. MOMA consists in a technical mission/visit for 1-3 weeks by

  6. Thermodynamic assessment of the rhodium-ruthenium-oxygen (Rh-Ru-O) system

    Science.gov (United States)

    Gossé, S.; Bordier, S.; Guéneau, C.; Brackx, E.; Domenger, R.; Rogez, J.

    2018-03-01

    Ruthenium (Ru) and rhodium (Rh) are abundant platinum-group metals formed during burn-up of nuclear fuels. Under normal operating conditions, Rh and Ru accumulate and predominantly form metallic precipitates with other fission products like Mo, Pd and Tc. In the framework of vitrification of high-level nuclear waste, these fission products are poorly soluble in molten glasses. They precipitate as metallic particles and oxide phases. Moreover, these Ru and Rh rich phases strongly depend on temperature and the oxygen fugacity of the glass melt. In case of severe accidental conditions with air ingress, oxidation of the Ru and Rh is possible. At low temperatures (T 1422 K for rhodium sesquioxide and T > 1815 K for ruthenium dioxide), they may decompose into (Rh)-FCC or (Ru)-HCP metallic phases and radiotoxic volatile gaseous species. A thermodynamic assessment of the Rh-Ru-O system will enable the prediction of: (1) the metallic and oxide phases that form during the vitrification of high-level nuclear wastes and (2) the release of volatile gaseous species during a severe accident. The Calphad method developed herein employs a thermodynamic approach in the investigation of the thermochemistry of rhodium and ruthenium at high temperatures. Current literature on the thermodynamic properties and phase diagram data enables preliminary thermodynamic assessments of the Rh-O and Ru-O systems. Additionally, select compositions in the ternary Rh-Ru-O system underwent experimental tests to complement data found in literature and to establish the phase equilibria in the ternary system.

  7. Assessing maintenance contracts when preventive maintenance is outsourced

    International Nuclear Information System (INIS)

    Wu Shaomin

    2012-01-01

    In some companies, corrective maintenance is conducted in-house but preventive maintenance might be outsourced. This raises a need to optimise some parameters such as the number of contracts from a perspective of the equipment owner. This paper considers a maintenance policy for such a situation, analyses the roles of the parameters in a PM model, proposes approaches to defining bonus functions, and finally discusses special cases of both the PM policy and the bonus function. Numerical examples are also given to explore the impact of parameters on the expected lifecycle cost rate.

  8. Rh Incompatibility

    Science.gov (United States)

    ... type is called Rh. Rh factor is a protein on red blood cells. Most people are Rh-positive; they have Rh factor. Rh-negative people don't have it. Rh factor is inherited though genes. When you're pregnant, blood from your baby can cross into your ...

  9. Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.

    Directory of Open Access Journals (Sweden)

    Andrew R Williams

    Full Text Available No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, a P. falciparum-specific protein expressed in merozoites, is efficiently targeted by broadly-neutralizing, vaccine-induced antibodies. Here we show that antibodies against PfRH5 efficiently inhibit the in vitro growth of short-term-adapted parasite isolates from Cambodia, and that the EC(50 values of antigen-specific antibodies against PfRH5 are lower than those against PfAMA1. Since antibody responses elicited by multiple antigens are speculated to improve the efficacy of blood-stage vaccines, we conducted detailed assessments of parasite growth inhibition by antibodies against PfRH5 in combination with antibodies against seven other merozoite antigens. We found that antibodies against PfRH5 act synergistically with antibodies against certain other merozoite antigens, most notably with antibodies against other erythrocyte-binding antigens such as PfRH4, to inhibit the growth of a homologous P. falciparum clone. A combination of antibodies against PfRH4 and basigin, the erythrocyte receptor for PfRH5, also potently inhibited parasite growth. This methodology provides the first quantitative evidence that polyclonal vaccine-induced antibodies can act synergistically against P. falciparum antigens and should help to guide the rational development of future multi-antigen vaccines.

  10. Gonadotropin Releasing Hormone (GnRH) Neuron Migration: Initiation, Maintenance and Cessation as Critical Steps to Ensure Normal Reproductive Function

    OpenAIRE

    Wierman, Margaret E.; Kiseljak-Vassiliades, Katja; Tobet, Stuart

    2010-01-01

    GnRH neurons follow a carefully orchestrated journey from their birth in the olfactory placode area. Initially, they migrate along with the vomeronasal nerve into the brain at the cribriform plate, then progress caudally to sites within the hypothalamus where they halt and send projections to the median eminence to activate pituitary gonadotropes. Many factors controlling this precise journey have been elucidated by the silencing or over expression of candidate genes in mouse models. Importan...

  11. Assessment of ocular beta radiation dose distribution due to 106Ru/106Rh brachytherapy applicators using MCNPX Monte Carlo code

    Directory of Open Access Journals (Sweden)

    Nilseia Aparecida Barbosa

    2014-08-01

    Full Text Available Purpose: Melanoma at the choroid region is the most common primary cancer that affects the eye in adult patients. Concave ophthalmic applicators with 106Ru/106Rh beta sources are the more used for treatment of these eye lesions, mainly lesions with small and medium dimensions. The available treatment planning system for 106Ru applicators is based on dose distributions on a homogeneous water sphere eye model, resulting in a lack of data in the literature of dose distributions in the eye radiosensitive structures, information that may be crucial to improve the treatment planning process, aiming the maintenance of visual acuity. Methods: The Monte Carlo code MCNPX was used to calculate the dose distribution in a complete mathematical model of the human eye containing a choroid melanoma; considering the eye actual dimensions and its various component structures, due to an ophthalmic brachytherapy treatment, using 106Ru/106Rh beta-ray sources. Two possibilities were analyzed; a simple water eye and a heterogeneous eye considering all its structures. Two concave applicators, CCA and CCB manufactured by BEBIG and a complete mathematical model of the human eye were modeled using the MCNPX code. Results and Conclusion: For both eye models, namely water model and heterogeneous model, mean dose values simulated for the same eye regions are, in general, very similar, excepting for regions very distant from the applicator, where mean dose values are very low, uncertainties are higher and relative differences may reach 20.4%. For the tumor base and the eye structures closest to the applicator, such as sclera, choroid and retina, the maximum difference observed was 4%, presenting the heterogeneous model higher mean dose values. For the other eye regions, the higher doses were obtained when the homogeneous water eye model is taken into consideration. Mean dose distributions determined for the homogeneous water eye model are similar to those obtained for the

  12. A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance.

    Science.gov (United States)

    Hoffmann, Hanne M; Mellon, Pamela L

    2016-01-01

    Fertility depends on the correct maturation and function of approximately 800 gonadotropin-releasing hormone (GnRH) neurons in the brain. GnRH neurons are at the apex of the hypothalamic-pituitary-gonadal axis that regulates fertility. In adulthood, GnRH neurons are scattered throughout the anterior hypothalamic area and project to the median eminence, where GnRH is released into the portal vasculature to stimulate release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. LH and FSH then regulate gonadal steroidogenesis and gametogenesis. Absence of GnRH neurons or inappropriate GnRH release leads to infertility. Despite the critical role of GnRH neurons in fertility, we still have a limited understanding of the genes responsible for proper GnRH neuron development and function in adulthood. GnRH neurons originate in the olfactory placode then migrate into the brain. Homeodomain transcription factors expressed within GnRH neurons or along their migratory path are candidate genes for inherited infertility. Using a combined in vitro and in vivo approach, we have identified Ventral Anterior Homeobox 1 ( Vax1 ) as a novel homeodomain transcription factor responsible for GnRH neuron maturation and fertility. GnRH neuron counts in Vax1 knock-out embryos revealed Vax1 to be required for the presence of GnRH-expressing cells at embryonic day 17.5 (E17.5), but not at E13.5. To localize the effects of Vax1 on fertility, we generated Vax1 flox mice and crossed them with Gnrh cre mice to specifically delete Vax1 within GnRH neurons. GnRH staining in Vax1 flox/flox :GnRH cre mice show a total absence of GnRH expression in the adult. We performed lineage tracing in Vax1 flox/flox :GnRH cre :RosaLacZ mice which proved GnRH neurons to be alive, but incapable of expressing GnRH. The absence of GnRH leads to delayed puberty, hypogonadism and complete infertility in both sexes. Finally, using the immortalized model GnRH neuron cell lines, GN11 and

  13. ATTENTION MAINTENANCE IN NOVICE DRIVERS: ASSESSMENT AND TRAINING

    OpenAIRE

    Pradhan, Anuj; Masserang, Kathleen M.; Divekar, Gautam; Reagan, Ian; Thomas, F. Dennis; Blomberg, Richard; Pollatsek, Alexander; Fisher, Donald

    2009-01-01

    All programs assessing attention maintenance inside the vehicle have required eye trackers and either a driving simulator or a specially equipped field vehicle. Ideally, one would like a way to assess attention maintenance that could be implemented on a desktop PC. Additionally, one would like to have a program that could be used to train novice drivers to maintain their attention more safely on the forward roadway. An experiment was run (a) to determine whether a program FOCAL (Focused Conce...

  14. Road Maintenance and Rehabilitation Program Using Functional and Structural Assessment

    Science.gov (United States)

    Setianingsih, A. I.; Sangaji, S.; Setyawan, A.

    2017-02-01

    Road sector development policy in Bangka Belitung emphasis on equitable development, which is opening up new areas for industrial development zones of potential marine and coastal tourism, so that having an impact on the budget priority to build a new road. This led to a minimal budget provided for the maintenance of the existing road. This study aimed to evaluate the condition of the pavement both functionally and structurally, the growth of traffic density and the availability of existing road maintenance costs. Then, to analyze the influence of existing road conditions, traffic density and road maintenance costs to the type of road maintenance management. The results are compared with the results of the existing maintenance conducted by the Public Works Department of Bangka Belitung province. Evaluation of pavement conditions consists of visual assessment of pavement condition using IRI, pavement condition assessment functionally with deflection method using test data tool Benkelman Beam (BB) and the actual traffic load. IRI value, deflections and traffic growth gained from years 2011-2015 subsequently created regression models to obtain the relationship and the correlation coefficient. The analysis showed that using the same relative magnitude of the budget from 2011 to 2015, giving priority to the maintenance of the road with good conditions capable of providing the road with a steady state of 100%. Recommendations can be given that maintain the road with good conditions reflecting that preservation provide maximum results with the more efficient maintenance cost.

  15. Optimizing stormwater treatment practices a handbook of assessment and maintenance

    CERN Document Server

    Erickson, Andrew J; Gulliver, John S

    2013-01-01

    Optimizing Stormwater Treatment Practices: A Handbook of Assessment and Maintenance provides the information necessary for developing and operating an effective maintenance program for stormwater treatment. The book offers instructions on how to measure the level of performance of stormwater treatment practices directly and bases proposed maintenance schedules on actual performance and historical maintenance efforts and costs. The inspection methods, which are proven in the field and have been implemented successfully, are necessary as regulatory agencies are demanding evaluations of the performance of stormwater treatment practices. The authors have developed a three-tiered approach that offers readers a standard protocol for how to determine the effectiveness of stormwater treatment practices currently in place. This book also: Provides a standard protocol for how to determine the effectiveness of stormwater treatment practices Assists readers with identifying which assessment techniques to use for stormwa...

  16. Life cycle assessment of asphalt pavement maintenance.

    Science.gov (United States)

    2014-01-01

    This study aims at developing a life cycle assessment (LCA) model to quantify the impact of pavement preservation on energy consumption and greenhouse gas (GHG) emissions. The construction stage contains material, manufacture, transportation and plac...

  17. Pre-conceptual design assessment of DEMO remote maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Loving, A., E-mail: antony.loving@ccfe.ac.uk [EURATOM/Culham Center Fusion Energy, Culham Science Centre, OX14 3DB, Abingdon (United Kingdom); Crofts, O.; Sykes, N.; Iglesias, D.; Coleman, M.; Thomas, J. [EURATOM/Culham Center Fusion Energy, Culham Science Centre, OX14 3DB, Abingdon (United Kingdom); Harman, J. [EFDA Close Support Unit Garching, Boltzmannstaße 2, D-85748 Garching Bei München (Germany); Fischer, U. [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Sanz, J. [Instituto de Fusión Nuclear/UPM, Madrid (Spain); Siuko, M. [VTT Technical Research Centre of Finland, P.O. Box 1000, FI-02044 VTT (Finland); Mittwollen, M. [Karlsruhe Institute of Technology, Institut für Fördertechnik und Logistiksysteme, Gotthard-Franz-Straße 8, Geb.50.38, 76131 Karlsruhe (Germany)

    2014-10-15

    EDFA, as part of the Power Plant Physics and Technology programme, has been working on the pre-conceptual design of a Demonstration Power Plant (DEMO). As part of this programme, a review of the remote maintenance strategy considered maintenance solutions compatible with expected environmental conditions, whilst showing potential for meeting the plant availability targets. A key finding was that, for practical purposes, the expected radiation levels prohibit the use of complex remote handling operations to replace the first wall. In 2012/2013, these remote maintenance activities were further extended, providing an insight into the requirements, constraints and challenges. In particular, the assessment of blanket and divertor maintenance, in light of the expected radiation conditions and availability, has elaborated the need for a very different approach from that of ITER. This activity has produced some very informative virtual reality simulations of the blanket segments and pipe removal that are exceptionally valuable in communicating the complexity and scale of the required operations. Through these simulations, estimates of the maintenance task durations have been possible demonstrating that a full replacement of the blankets within 6 months could be achieved. The design of the first wall, including the need to use sacrificial limiters must still be investigated. In support of the maintenance operations, a first indication of the requirements of an Active Maintenance Facility (AMF) has been elaborated.

  18. Pharmacological and toxicological assessment of a potential GnRH vaccine in young-adult male pigs

    NARCIS (Netherlands)

    Turkstra, J.A.; Staay, van der F.J.; Stockhofe-Zurwieden, N.; Woelders, H.; Meloen, R.H.; Schuurman, T.

    2011-01-01

    Active immunization against gonadotrophin-releasing hormone (GnRH) is successfully applied to prevent boar taint in pork. In men, GnRH immunization could be an alternative to hormone therapy in patients with prostate cancer. In this study, a new GnRH vaccine formulation (a modified GnRH peptide

  19. Using systematic aging assessments to improve effectiveness of plant maintenance programs

    International Nuclear Information System (INIS)

    Watson, P.; Yang, J.X.; Dam, R.F.; Nickerson, J.H.

    2003-01-01

    Nuclear plant equipment aging assessment studies provided by AECL include life assessments, condition assessments or systematic assessments of maintenance. AECL has developed several tools to apply the results of aging assessment studies to improve the effectiveness of actual plant maintenance programs. The Systematic Assessment of Maintenance and the SYSTMS tool generate maintenance tasks for a system. The System Maintenance Datastore tool assesses the maintenance resources on a system basis, and can thus quantify the savings realized by optimizing the maintenance program. Long term trends in condition-based maintenance due to component aging can be predicted, and resource savings due to optimum timing of component replacement or general plant refurbishment can be quantified. The System based Adaptive Maintenance Process ensures the maintenance program is continually updated to reflect the latest plant equipment condition and maintenance strategy information. (author)

  20. Assessment of a water hydraulics joint for RH operations in the divertor region

    International Nuclear Information System (INIS)

    Dubus, G.; David, O.; Measson, Y.; Friconneau, J.P.

    2007-01-01

    force control loops were assessed and endurance tests were performed. Loads and trajectories applied on the mock-up during the trials were defined according to representative Remote Handling tasks during maintenance operations. (orig.)

  1. Assessment of a water hydraulics joint for RH operations in the divertor region

    Energy Technology Data Exchange (ETDEWEB)

    Dubus, G.; David, O.; Measson, Y.; Friconneau, J.P. [CEA LIST, Interactive Robotics Unit (France)

    2007-07-01

    and force control loops were assessed and endurance tests were performed. Loads and trajectories applied on the mock-up during the trials were defined according to representative Remote Handling tasks during maintenance operations. (orig.)

  2. The machines maintenance conditions assessment in the plastic industry

    Directory of Open Access Journals (Sweden)

    Stanisław Borkowski

    2015-12-01

    Full Text Available The purpose, methodology, main findings, the originality of the subject area (research, way of using. The main research analysis purpose is a presentation, an assessment and an interpretation of the research findings on the machines maintenance conditions in the plastic industry. The research analysis was carried out with applying Technology ABC method and TPM coefficients calculations connected with Techno pak machine components maintenance. The research was carried out in the chosen manufacturing enterprise of the plastic industry. Research findings interpretation results have been introduced in the analyzed enterprise in the form of the manufacturing processes improvement.

  3. Contextual assessment of maintenance culture at Olkiluoto and Forsmark

    International Nuclear Information System (INIS)

    Reiman, T.; Oedewald, P.; Rollenhagen, C.; Eriksson, I.

    2004-04-01

    The study aims to characterise, assess and develop the organisational cultures of participating nuclear power companies' maintenance units. The assessment is made by the means of maintenance core task modelling that has already been started in previous studies. The theoretical core task model is used in evaluating the characteristics of the organisational culture. We aim to identify what are the strengths and weaknesses of the case organisation's culture in relation to its core task. The study also aims to validate the methodology for contextual assessment of organisational culture. In addition to case specific results, the study acts as a benchmark between the participating companies and gives a chance to compare the different culture profiles between the companies. Similarities and differences between the organisational cultures at the maintenance units were identified. The purpose is not however to evaluate which organisation is better, but to raise issues that require attention at the organisations. When evaluative statements are made, the criteria are formed on the basis of the core task model: Even though the practices differ, from the perspective of the maintenance core task they might both be as effective. (au)

  4. Contextual assessment of maintenance culture at Olkiluoto and Forsmark

    Energy Technology Data Exchange (ETDEWEB)

    Reiman, T.; Oedewald, P. [VTT Industrial Systems (Finland); Rollenhagen, C.; Eriksson, I. [Maelardalen University (Sweden)

    2004-04-01

    The study aims to characterise, assess and develop the organisational cultures of participating nuclear power companies' maintenance units. The assessment is made by the means of maintenance core task modelling that has already been started in previous studies. The theoretical core task model is used in evaluating the characteristics of the organisational culture. We aim to identify what are the strengths and weaknesses of the case organisation's culture in relation to its core task. The study also aims to validate the methodology for contextual assessment of organisational culture. In addition to case specific results, the study acts as a benchmark between the participating companies and gives a chance to compare the different culture profiles between the companies. Similarities and differences between the organisational cultures at the maintenance units were identified. The purpose is not however to evaluate which organisation is better, but to raise issues that require attention at the organisations. When evaluative statements are made, the criteria are formed on the basis of the core task model: Even though the practices differ, from the perspective of the maintenance core task they might both be as effective. (au)

  5. Human Error Probability Assessment During Maintenance Activities of Marine Systems

    Directory of Open Access Journals (Sweden)

    Rabiul Islam

    2018-03-01

    Full Text Available Background: Maintenance operations on-board ships are highly demanding. Maintenance operations are intensive activities requiring high man–machine interactions in challenging and evolving conditions. The evolving conditions are weather conditions, workplace temperature, ship motion, noise and vibration, and workload and stress. For example, extreme weather condition affects seafarers' performance, increasing the chances of error, and, consequently, can cause injuries or fatalities to personnel. An effective human error probability model is required to better manage maintenance on-board ships. The developed model would assist in developing and maintaining effective risk management protocols. Thus, the objective of this study is to develop a human error probability model considering various internal and external factors affecting seafarers' performance. Methods: The human error probability model is developed using probability theory applied to Bayesian network. The model is tested using the data received through the developed questionnaire survey of >200 experienced seafarers with >5 years of experience. The model developed in this study is used to find out the reliability of human performance on particular maintenance activities. Results: The developed methodology is tested on the maintenance of marine engine's cooling water pump for engine department and anchor windlass for deck department. In the considered case studies, human error probabilities are estimated in various scenarios and the results are compared between the scenarios and the different seafarer categories. The results of the case studies for both departments are also compared. Conclusion: The developed model is effective in assessing human error probabilities. These probabilities would get dynamically updated as and when new information is available on changes in either internal (i.e., training, experience, and fatigue or external (i.e., environmental and operational conditions

  6. Cost assessment of demo fusion reactor with considering maintenance

    International Nuclear Information System (INIS)

    Hashizume, Hidetoshi; Kitagoh, Kazutoshi

    2003-01-01

    The purpose of this study is to perform cost assessment of nuclear fusion reactors in order to draw up commercial plants. A fusion reactor may have a complex configuration to achieve high beta value, which leads to low and instable availability when maintenance is taken into account. Therefore, reactor's availability must be evaluated with considering the influence of the configuration complexity. Furthermore the availability has the strong impact on COE (Cost of Electricity), that is, a fusion reactor with low availability will not be accepted as a commercial plant. Therefore, we developed a new method to calculate availabilities with random numbers, in which the complexity of reactor's configuration could become considered. In addition, we considered the reduction of superconducting coil's maintenance time by introducing remountable magnet system because the coil maintenance requires quite long time in the present technology. The results show that the availability becomes relatively large if the short maintenance time of coils could be achieved, for example, by remountable magnetic systems. (author)

  7. Assessment of building maintenance in Nigerian university system ...

    African Journals Online (AJOL)

    Building maintenance involves preserving a building so that it can retain its economic value ... maintenance policy by employing outsourcing maintenance services. ... services including the use of information and communication technology.

  8. A Study on the Maintenance Effectiveness Assessment for Active Components

    International Nuclear Information System (INIS)

    Lim, Woo Sang; Oh, Seung Jong

    2006-01-01

    One of the key tasks in the periodic safety review (PSR) of nuclear power plant is to assess the aging management of structures, systems and components (SSC). The evaluation can be categorized by two parts, passive and active components. Unlike the passive components, active components are periodically maintained and replaced with new components, so the evaluation of aging mechanism of the passive components such as erosion, corrosion is not applicable to the evaluation of active components of nuclear power plant. For active components, they will maintain capability to fulfill its design function if preventive maintenance effectiveness is proper. In this paper, the assessment based on the reliability and availability of the active components of the domestic nuclear power plants is examined

  9. Risk Assessment to Dust Exposure in Room Maintenance

    Directory of Open Access Journals (Sweden)

    Saiku Rokhim

    2017-04-01

    Full Text Available As one of the particulate chemicals, dust could occur in most of the production process and can create interference for workers health and safety. As one of the air pollution sources, dust could became a potential hazard which exist in room maintenances. Protection to workers is a must in order to reduce the risk of respiratory tract syndrome that often could be found in this cases. The aim of this study is to conduct a risk assessment to dust exposure in room maintenance, which held by contractors in PT. X (Persero building in Surabaya. This is an cross sectional study with obsevation approach. The object of this research is the repairing  works. The results indicate that the activities which could produce dust, such as: walls sanding using sandpaper, the tiles dismantle, sawmilling, the wood fiber refining, grinding, mixing and stirring cast  materials, and room cleaning. Dust produced from a variety of works including sanddust, cement, lime, wood and dust mixed with paint. The results show that three types of works considere as high-risk activity (value > 12-25, 3 types of work consider as midle risk activities (value > 5-12, and one activity considered as a low-risk work (grades 1-5. The dusk factors controlling should be held regularly, in order to minimize the risk leveln againts the workers.

  10. Analysis of ITER upper port plug remote handling maintenance scenarios

    International Nuclear Information System (INIS)

    Koning, J.F.; Baar, M.R. de; Elzendoorn, B.S.Q.; Heemskerk, C.J.M.; Ronden, D.M.S.; Schuth, W.J.

    2012-01-01

    Highlights: ► Remote Handling Study Centre: providing RH compatibility analysis. ► Simulation: virtual reality including kinematics and realtime physics simulator. ► Applied on analysis of RH compatibility of Upper Launcher component replacement. ► Resulting in lowered maintenance procedure time and lessons learned. - Abstract: The ITER tokamak has a modular design, with port plugs, blanket modules and divertor cassettes. This set-up allows for maintenance of diagnostics, heating systems and first wall elements. The maintenance can be done in situ, or in the Hot Cell. Safe and effective remote handling (RH) will be ensured by the RH requirements and standards. Compliance is verified through remote handling compatibility assessments at the ITER Design Review milestones. The Remote Handling Study Centre at FOM Institute DIFFER is created to study ITER RH maintenance processes at different levels of complexity, from relatively simple situational awareness checks using snap-shots in the CAD system, time studies using virtual reality (VR) animations, to extensive operational sequence validation with multiple operators in real-time. The multi-operator facility mimics an RH work-cell as presently foreseen in the ITER RH control room. Novel VR technology is used to create a realistic setting in which a team of RH operators can interact with virtual ITER environments. A physics engine is used to emulate real-time contact interaction as to provide realistic haptic feed-back. Complex interactions between the RH operators and the control room system software are tested. RH task performance is quantified and operational resource usage estimated. The article provides a description and lessons learned from a recent study on replacement of the Steering Mirror Assembly on the ECRH (Electron Cyclotron Resonance Heating) Upper Launcher port plug.

  11. Analysis of ITER upper port plug remote handling maintenance scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Koning, J.F., E-mail: j.f.koning@heemskerk-innovative.nl [FOM Institute DIFFER - Dutch Institute for Fundamental Energy Research, Association EURATOM-FOM, Partner in the Trilateral Euregio Cluster and ITER-NL, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Baar, M.R. de; Elzendoorn, B.S.Q. [FOM Institute DIFFER - Dutch Institute for Fundamental Energy Research, Association EURATOM-FOM, Partner in the Trilateral Euregio Cluster and ITER-NL, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Heemskerk, C.J.M. [Heemskerk Innovative Technology, Noordwijk (Netherlands); Ronden, D.M.S.; Schuth, W.J. [FOM Institute DIFFER - Dutch Institute for Fundamental Energy Research, Association EURATOM-FOM, Partner in the Trilateral Euregio Cluster and ITER-NL, PO Box 1207, 3430 BE Nieuwegein (Netherlands)

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer Remote Handling Study Centre: providing RH compatibility analysis. Black-Right-Pointing-Pointer Simulation: virtual reality including kinematics and realtime physics simulator. Black-Right-Pointing-Pointer Applied on analysis of RH compatibility of Upper Launcher component replacement. Black-Right-Pointing-Pointer Resulting in lowered maintenance procedure time and lessons learned. - Abstract: The ITER tokamak has a modular design, with port plugs, blanket modules and divertor cassettes. This set-up allows for maintenance of diagnostics, heating systems and first wall elements. The maintenance can be done in situ, or in the Hot Cell. Safe and effective remote handling (RH) will be ensured by the RH requirements and standards. Compliance is verified through remote handling compatibility assessments at the ITER Design Review milestones. The Remote Handling Study Centre at FOM Institute DIFFER is created to study ITER RH maintenance processes at different levels of complexity, from relatively simple situational awareness checks using snap-shots in the CAD system, time studies using virtual reality (VR) animations, to extensive operational sequence validation with multiple operators in real-time. The multi-operator facility mimics an RH work-cell as presently foreseen in the ITER RH control room. Novel VR technology is used to create a realistic setting in which a team of RH operators can interact with virtual ITER environments. A physics engine is used to emulate real-time contact interaction as to provide realistic haptic feed-back. Complex interactions between the RH operators and the control room system software are tested. RH task performance is quantified and operational resource usage estimated. The article provides a description and lessons learned from a recent study on replacement of the Steering Mirror Assembly on the ECRH (Electron Cyclotron Resonance Heating) Upper Launcher port plug.

  12. Rh Incompatibility (For Parents)

    Science.gov (United States)

    ... work to destroy, foreign substances) against the Rh proteins. Other ways Rh-negative pregnant women can be exposed to the Rh protein that might cause antibody production include blood transfusions ...

  13. RH Packaging Program Guidance

    International Nuclear Information System (INIS)

    2008-01-01

    The purpose of this program guidance document is to provide the technical requirements for use, operation, inspection, and maintenance of the RH-TRU 72-B Waste Shipping Package (also known as the 'RH-TRU 72-B cask') and directly related components. This document complies with the requirements as specified in the RH-TRU 72-B Safety Analysis Report for Packaging (SARP), and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9212. If there is a conflict between this document and the SARP and/or C of C, the C of C shall govern. The C of C states: 'each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, Operating Procedures, of the application.' It further states: 'each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, Acceptance Tests and Maintenance Program of the Application.' Chapter 9.0 of the SARP tasks the Waste Isolation Pilot Plant (WIPP) Management and Operating (M and O) Contractor with assuring the packaging is used in accordance with the requirements of the C of C. Because the packaging is NRC-approved, users need to be familiar with Title 10 Code of Federal Regulations (CFR) 71.8, 'Deliberate Misconduct.' Any time a user suspects or has indications that the conditions of approval in the C of C were not met, the U.S. Department of Energy (DOE) Carlsbad Field Office (CBFO) shall be notified immediately. The CBFO will evaluate the issue and notify the NRC if required.In accordance with 10 CFR Part 71, 'Packaging and Transportation of Radioactive Material,' certificate holders, packaging users, and contractors or subcontractors who use, design, fabricate, test, maintain, or modify the packaging shall post copies of (1) 10 CFR Part 21, 'Reporting of Defects and Noncompliance,' regulations, (2) Section 206 of the Energy Reorganization Act of 1974, and (3) NRC Form 3, Notice to Employees. These documents must be posted in a conspicuous

  14. Assessing the Value Dimensions of Outsourced Maintenance Services

    DEFF Research Database (Denmark)

    Toossi, Amir; Lockett, Helen Louise; Raja, Jawwad

    2013-01-01

    Purpose – The purpose of this paper is to investigate the diverse nature of tangible and intangible value dimensions that contribute to customers’ perception of value from outsourced maintenance services. Design/methodology/approach – A multiple case study approach has been adopted. Repertory grid......, an in-depth structured interviewing technique, has been used in order to draw out the respondents’ hidden constructs in evaluating outsourced maintenance services. Data have been collected from four customer organizations of outsourced maintenance services, and a total of 33 interviews have been...... undertaken. Findings – The paper has identified a range of tangible and intangible value dimensions that are of importance in maintenance outsourcing decision making. The most important value dimensions for maintenance outsourcing were found to be specialist knowledge, accessibility (of the service provider...

  15. Use of probabilistic risk assessment in maintenance activities at Palo Verde

    International Nuclear Information System (INIS)

    Lindquist, R.C.; Pobst, D.S.

    1993-01-01

    Probabilistic risk assessment (PRA) is an important tool in addressing various maintenance activities. At the Palo Verde nuclear generating station (PVNGS), the PRA has been used in a variety of ways to support a wide and diverse selection of maintenance-related activities. For on-line or at-power maintenance, the PRA was used to evaluate combinations of maintenance activities possible with the 12-week or floating maintenance schedule. The maintenance schedule was evaluated to identify any higher risk, undesirable combinations of equipment outages, such as the sole steam-driven auxiliary feedwater pump and the same train emergency diesel generator. Table I is a sampling of the results from the maintenance schedule evaluation in terms of increase in conditional core damage frequency (CDF) above the base- line value due to maintenance on some important key safety systems and combinations thereof. The baseline CDF is 7.4 x 10 -7 per 72 h

  16. Assessment of complex microwaves occupational exposure in radar maintenance activity

    International Nuclear Information System (INIS)

    Danulescu, R.

    1996-01-01

    The modern of the society teas determined the increase of thousand times greater than the natural fond of the humankind exposure to a complex combination of electromagnetic man-made fields and radiations of extremely various strength and frequencies. A special contribution to this environmental change has had in the last decade the appearance and the explosive development of the microwaves generating appliances such as radars used in a great variety of military and civilian applications and which essentially contributes to the electromagnetic pollution. In the above mentioned content which firstly interests the occupational environment, it is necessary to improve the exposure limits, as well as, the emission standards, in order to better protect the human health and well-being. From this point of view, the estimation of the microwave occupational exposure risk constitutes, alongside the health status assessment, one of the priorities of the Occupational Health because the theoretical and practical problems related to the bioeffects of this kind of radiations are far to be clarified. Our study has been carried out in a factory where one performs research, production and especially maintenance of microwaves generating devices. (author)

  17. Assessment and improvement of urban streets maintenance: Case study Kragujevac

    Directory of Open Access Journals (Sweden)

    Jokanović Igor

    2017-01-01

    Full Text Available City of Kragujevac struggles with providing road maintenance services due to limited funds and low capacity within the existing Public Utility Companies. As a solution to problems with traditional methods of contracting, many road authorities have moved to contracting road maintenance works to the private sector based on performance measures. The paper presents the outcomes of the study conducted for the purpose of improving current practice and condition of urban network within the City of Kragujevac through the application of performance-based maintenance contracting.

  18. Improved Navy Maintenance Through Corrosion-Fatigue Assessment Program

    National Research Council Canada - National Science Library

    Hoppe, Wally

    2008-01-01

    ... to evaluate issues relevant to corrosion-fatigue of aircraft components. In this multi-year, multi-contract program, tools have been developed to assist in the establishment of maintenance options for corroded components...

  19. Assessment of the Automotive Inspection, Maintenance, and Repair Industry

    Science.gov (United States)

    1981-02-01

    The study describes the current status of the Inspection/Maintenance/Repair Industry in the U.S., the impact of technological changes and legislation, and related approaches used in Germany and Sweden. Based on these findings suggestions are provided...

  20. Human Error Probability Assessment During Maintenance Activities of Marine Systems

    OpenAIRE

    Rabiul Islam; Faisal Khan; Rouzbeh Abbassi; Vikram Garaniya

    2018-01-01

    Background: Maintenance operations on-board ships are highly demanding. Maintenance operations are intensive activities requiring high man–machine interactions in challenging and evolving conditions. The evolving conditions are weather conditions, workplace temperature, ship motion, noise and vibration, and workload and stress. For example, extreme weather condition affects seafarers' performance, increasing the chances of error, and, consequently, can cause injuries or fatalities to personne...

  1. RH Packaging Program Guidance

    International Nuclear Information System (INIS)

    2006-01-01

    The purpose of this program guidance document is to provide the technical requirements for use, operation, inspection, and maintenance of the RH-TRU 72-B Waste Shipping Package and directly related components. This document complies with the requirements as specified in the RH-TRU 72-B Safety Analysis Report for Packaging (SARP), and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9212. If there is a conflict between this document and the SARP and/or C of C, the C of C shall govern. The C of C states: 'each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, Operating Procedures, of the application.' It further states: 'each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, Acceptance Tests and Maintenance Program of the Application.' Chapter 9.0 of the SARP tasks the Waste Isolation Pilot Plant (WIPP) Management and Operating (M and O) Contractor with assuring the packaging is used in accordance with the requirements of the C of C. Because the packaging is NRC-approved, users need to be familiar with 10 Code of Federal Regulations (CFR) 1.8, 'Deliberate Misconduct.' Any time a user suspects or has indications that the conditions of approval in the C of C were not met, the U.S. Department of Energy (DOE) Carlsbad Field Office (CBFO) shall be notified immediately. CBFO will evaluate the issue and notify the NRC if required. In accordance with 10 CFR Part 71, 'Packaging and Transportation of Radioactive Material,' certificate holders, packaging users, and contractors or subcontractors who use, design, fabricate, test, maintain, or modify the packaging shall post copies of (1) 10 CFR Part 21, 'Reporting of Defects and Noncompliance,' regulations, (2) Section 206 of the Energy Reorganization Act of 1974, and (3) NRC Form 3, Notice to Employees. These documents must be posted in a conspicuous location where the activities subject to these

  2. RH Packaging Program Guidance

    International Nuclear Information System (INIS)

    Washington TRU Solutions, LLC

    2003-01-01

    The purpose of this program guidance document is to provide technical requirements for use, operation, inspection, and maintenance of the RH-TRU 72-B Waste Shipping Package and directly related components. This document complies with the requirements as specified in the RH-TRU 72-B Safety Analysis Report for Packaging (SARP), and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9212. If there is a conflict between this document and the SARP and/or C of C, the SARP and/or C of C shall govern. The C of C states: ''...each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, ''Operating Procedures,'' of the application.'' It further states: ''...each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, ''Acceptance Tests and Maintenance Program of the Application.'' Chapter 9.0 of the SARP tasks the Waste Isolation Pilot Plant (WIPP) Management and Operating (M and O) contractor with assuring the packaging is used in accordance with the requirements of the C of C. Because the packaging is NRC approved, users need to be familiar with 10 CFR (section) 71.11, ''Deliberate Misconduct.'' Any time a user suspects or has indications that the conditions of approval in the C of C were not met, the Carlsbad Field Office (CBFO) shall be notified immediately. CBFO will evaluate the issue and notify the NRC if required. This document details the instructions to be followed to operate, maintain, and test the RH-TRU 72-B packaging. This Program Guidance standardizes instructions for all users. Users shall follow these instructions. Following these instructions assures that operations are safe and meet the requirements of the SARP. This document is available on the Internet at: ttp://www.ws/library/t2omi/t2omi.htm. Users are responsible for ensuring they are using the current revision and change notices. Sites may prepare their own document using the word

  3. Summary of Tiger Team Assessment and Technical Safety Appraisal recurring concerns in the Maintenance Area

    International Nuclear Information System (INIS)

    1993-01-01

    Tiger Team Assessments and Technical Safety Appraisals (TSA) were reviewed and evaluated for concerns in the Maintenance Area (MA). Two hundred and thirty one (231) maintenance concerns were identified by the Tiger Team Assessments and TSA reports. These recurring concerns appear below. A summary of the Noteworthy Practices that were identified and a compilation of the maintenance concerns for each performance objective that were not considered as recurring are also included. Where the Tiger Team Assessment and TSA identified the operating contractor or facility by name, the concern has been modified to remove the name while retaining the intent of the comment

  4. Assessing ABO/Rh Blood Group Frequency and Association with Asymptomatic Malaria among Blood Donors Attending Arba Minch Blood Bank, South Ethiopia

    Directory of Open Access Journals (Sweden)

    Getaneh Alemu

    2016-01-01

    Full Text Available Background. Determination of the various ABO/Rh blood group distributions and their association with malaria infection has paramount importance in the context of transfusion medicine and malaria control. Methods. Facility based cross-sectional study was conducted from February to June, 2015, to assess ABO/Rh blood groups distribution and their association with asymptomatic malaria. A structured questionnaire was used to collect data. Blood grouping was done using monoclonal antibodies. Thin and thick blood films were examined for Plasmodium parasites. Data were analyzed using SPSS version 20.0. Results. A total of 416 blood donors participated with median age of 22±0.29 (median ± standard error of the mean. Distribution of ABO phenotypes, in decreasing order, was O (175, 42.1%, A (136, 32.7%, B (87, 20.9%, and AB (18, 4.3%. Most of them were Rh+ (386, 92.8%. The overall malaria prevalence was 4.1% (17/416. ABO blood group is significantly associated with malaria infection (P=0.022. High rate of parasitemia was seen in blood group O donors (6.899, P=0.003 compared to those with other ABO blood groups. Conclusion. Blood groups O and AB phenotypes are the most and the least ABO blood groups, respectively. There is significant association between ABO blood group and asymptomatic malaria parasitemia.

  5. Longview District Operations and Maintenance Headquarters: Environmental assessment

    International Nuclear Information System (INIS)

    1992-03-01

    Bonneville Power Administration (BPA) operations and maintenance staff are presently based at a headquarters next to the Longview Substation. These headquarters buildings, however, were built in 1941 and have deteriorated to the point of needing extensive repair. They also lack sufficient inside storage space. New buildings cannot be constructed on the site because of surrounding development. In addition, the site is within an area exposed to industrial fallout (coal tar pitch and metallic particles) that may be damaging buildings, equipment, and vehicles. BPA is concerned about the potential health risk to headquarters staff from the fallout. In light of these problems, BPA proposes to construct a new operations and maintenance headquarters at a different location, and to demolish the existing headquarters. This paper discusses the environmental impacts of the proposed action and alternatives

  6. Global optimization of maintenance and surveillance testing based on reliability and probabilistic safety assessment. Research project

    International Nuclear Information System (INIS)

    Martorell, S.; Serradell, V.; Munoz, A.; Sanchez, A.

    1997-01-01

    Background, objective, scope, detailed working plan and follow-up and final product of the project ''Global optimization of maintenance and surveillance testing based on reliability and probabilistic safety assessment'' are described

  7. Assessment of building maintenance management practices of higher education institutions in Niger State - Nigeria

    Directory of Open Access Journals (Sweden)

    Ofide Blessing

    2015-12-01

    Full Text Available Higher education institutions face immediate pressure to preserve existing building facilities within the campuses and enhance the capacity of their higher education system to address growing demands of an increasing influx of students and academic activities. There is no doubt that dilapidated and unhealthy buildings in a decaying environment depresses the quality of life and contributes in some measure to antisocial behaviours. The buildings of higher education institutions in Nigeria only receive top management attention when there is a problem. Hence, the paper assessed the building maintenance management practices of 6 higher institutions available (2 universities, 2 polytechnics and 2 colleges of education in Niger State. This was done by interviewing the Directors of Works of the 6 institutions using a structured interview method. The study revealed that there was no maintenance manual in any of the Works Department of the higher education institution, no user satisfaction survey has ever been conducted and none of the institutions had a computerised maintenance management system (CMMS in place. In addition to these, corrective maintenance was mostly adopted and there was inadequate staffing of the field operatives. All these shortcomings might be responsible for the backlog of maintenance work experienced in the institutions studied. A proactive maintenance system should be put in place, CMMS should be adopted to enhance effective maintenance work, and top management should be enlightened on the imperative of maintenance among other issues competing for funds within the institutions and be more flexible in allocation of resources to enhance maintenance works.

  8. Maintenance self-assessments - An INPO [Institute of Nuclear Power Operation] perspective

    International Nuclear Information System (INIS)

    Subalusky, W.T.

    1990-01-01

    In March 1987, all nuclear utilities in the US were requested by the Institute of Nuclear Power Operations (INPO) to perform a self-assessment of their maintenance programs. The goal of these self-assessments was to have each station identify any existing problem areas in maintenance in clear and sufficient detail to determine the root causes of the problems and to provide a foundation for subsequent corrective actions. The self-assessments were to be performed by each nuclear station using the INPO document Guidelines for the Conduct of Maintenance at Nuclear Power Stations. By December 1987, 72 of 74 stations had completed the self-assessments, and by the middle of 1988, all stations had completed this systematic review of their maintenance programs. As part of an industry plan to ensure continued improvements in maintenance, INPO is following up on the effectiveness of these self-assessments during the course of plant evaluation visits. This presentation briefly reviews the approaches to self-assessment of the station's maintenance programs, some of the lessons learned from this effort, and the results, to date, of INPO follow-up efforts in this area

  9. Probabilistic safety assessment support for the maintenance rule at Duke Power Company

    International Nuclear Information System (INIS)

    Brewer, H. Duncan; Canady, Ken S.

    1999-01-01

    The Nuclear Regulatory Commission (NRC) published the Maintenance Rule on July 10, 1991 with an implementation date of July 10, 1996 . Maintenance rule implementation at the Duke Power Company has used probabilistic safety assessment (PSA) insights to help focus the monitoring of structures, systems and components (SSC) performance and to ensure that maintenance is effectively performed. This paper describes how the probabilistic risk assessment (PRA) group at the Duke Power Company provides support for the maintenance rule by performing the following tasks: (1) providing a member of the expert panel; (2) determining the risk-significant SSCs; (3) establishing SSC performance criteria for availability and reliability; (4) evaluating past performance and its impact on core damage risk as part of the periodic assessment; (5) providing input to the PRA matrix; (6) providing risk analyses of combinations of SSCs out of service; (7) providing support for the SENTINEL program; and (8) providing support for PSA training. These tasks are not simply tied to the initial implementation of the rule. The maintenance rule must be kept consistent with the current design and operation of the plant. This will require that the PRA models and the many PSA calculations performed to support the maintenance rule are kept up-to-date. Therefore, support of the maintenance rule will be one of the primary roles of the PSA group for the remainder of the life of the plant

  10. Reliability assessment of power pole infrastructure incorporating deterioration and network maintenance

    International Nuclear Information System (INIS)

    Ryan, Paraic C.; Stewart, Mark G.; Spencer, Nathan; Li, Yue

    2014-01-01

    There is considerable investment in timber utility poles worldwide, and there is a need to examine the structural reliability and probability based management optimisation of these power distribution infrastructure elements. The work presented in this paper builds on the existing studies in this area through assessment of both treated and untreated timber power poles, with the effects of deterioration and network maintenance incorporated in the analysis. This more realistic assessment approach, with deterioration and maintenance considered, was achieved using event-based Monte Carlo simulation. The output from the probabilistic model is used to illustrate the importance of considering network maintenance in the time-dependent structural reliability assessment of timber power poles. Under wind load, treated and untreated poles designed and maintained in accordance with existing Australian standards were found to have similar failure rates. However, untreated pole networks required approximately twice as many maintenance based pole replacements to sustain the same level of reliability. The effect of four different network maintenance strategies on infrastructure performance was also investigated herein. This assessment highlighted the fact that slight alterations to network maintenance practices can lead to significant changes in performance of timber power pole networks. - Highlights: • A time-dependent structural reliability model was developed for timber power poles. • Deterioration and network maintenance were incorporated into this event based model. • Network maintenance had a significant impact on power pole wind vulnerability. • Treated and untreated poles designed to Australian standards had similar reliability. • Minor alterations to maintenance strategies had large effects on network performance

  11. Assessment of a maintenance model for a multi-deteriorating mode system

    International Nuclear Information System (INIS)

    Ponchet, Amelie; Fouladirad, Mitra; Grall, Antoine

    2010-01-01

    This paper deals with maintenance policies for stochastically deteriorating systems which are subject to sudden changes in their degradation processes. The main aim is to assess the interest of using change mode monitoring information from a maintenance decision making point of view. Two condition-based maintenance policies are considered and compared, each of them adapted to a specific level of available information, with or without change mode monitoring. Numerical examples show that the time distribution of the change of deterioration rate and the difference between the two possible deterioration rates strongly influence the choice of the best decision rule structure.

  12. Assessment of a maintenance model for a multi-deteriorating mode system

    Energy Technology Data Exchange (ETDEWEB)

    Ponchet, Amelie, E-mail: amelie.ponchet@utt.f [Institut Charles Delaunay, Universite de technologie de Troyes, UMR CNRS 6279 STMR, 12 rue Marie Curie, 10010 Troyes (France); Fouladirad, Mitra [Institut Charles Delaunay, Universite de technologie de Troyes, UMR CNRS 6279 STMR, 12 rue Marie Curie, 10010 Troyes (France); Grall, Antoine, E-mail: antoine.grall@utt.f [Institut Charles Delaunay, Universite de technologie de Troyes, UMR CNRS 6279 STMR, 12 rue Marie Curie, 10010 Troyes (France)

    2010-11-15

    This paper deals with maintenance policies for stochastically deteriorating systems which are subject to sudden changes in their degradation processes. The main aim is to assess the interest of using change mode monitoring information from a maintenance decision making point of view. Two condition-based maintenance policies are considered and compared, each of them adapted to a specific level of available information, with or without change mode monitoring. Numerical examples show that the time distribution of the change of deterioration rate and the difference between the two possible deterioration rates strongly influence the choice of the best decision rule structure.

  13. Maintenance & Repair Cost Calculation and Assessment of Resale Value for Different Alternative Commercial Vehicle Powertrain Technologies

    OpenAIRE

    Kleiner, Florian; Friedrich, Horst E.

    2017-01-01

    For detailed evaluation of the Total Cost of Ownership, expenditures for Maintenance & Repair as well as the resale value are important to consider and should not be neglected. However, information on Maintenance & Repair costs as well as residual values for commercial vehicles with alternative powertrains is missing and data on this issue is rare. There is a lack of information and consolidated knowledge. In order to enable a holistic cost assessment for commercial vehicles, a comprehensive ...

  14. Social Health Maintenance Organizations: assessing their initial experience.

    Science.gov (United States)

    Newcomer, R; Harrington, C; Friedlob, A

    1990-08-01

    The Social/Health Maintenance Organization (S/HMO) is a four-site national demonstration. This program combines Medicare Part A and B coverage, with various extended and chronic care benefits, into an integrated health plan. The provision of these services extends both the traditional roles of HMOs and that of long-term care community-service case management systems. During the initial 30 months of operation the four S/HMOs shared financial risk with the Health Care Financing Administration. This article reports on this developmental period. During this phase the S/HMOs had lower-than-expected enrollment levels due in part to market competition, underfunding of marketing efforts, the limited geographic area served, and an inability to differentiate the S/HMO product from that of other Medicare HMOs. The S/HMOs were allowed to conduct health screening of applicants prior to enrolling them. The number of nursing home-certifiable enrollees was controlled through this mechanism, but waiting lists were never very long. Persons joining S/HMOs and other Medicare HMOs during this period were generally aware of the alternatives available. S/HMO enrollees favored the more extensive benefits; HMO enrollees considerations of cost. The S/HMOs compare both newly formed HMOs and established HMOs. On the basis of administrator cost, it is more efficient to add chronic care benefits to an HMO than to add an HMO component to a community care provider. All plans had expenses greater than their revenues during the start-up period, but they were generally able to keep service expenditures within planned levels.

  15. Monte Carlo Risk Assessment (MCRA) software: maintenance and management 2016

    NARCIS (Netherlands)

    Boon PE; van der Voet H; Boer WJ; Kruisselbrink J; van Lenthe M; van Klaveren JD; VVH; V&Z

    2017-01-01

    This report shows the adjustments in the Monte Carlo Risk Assessment (MCRA) computational model implemented by RIVM and Wageningen UR Biometris in 2016. MCRA is a computational tool that presently gives the most realistic chemical intake via food. The model is available for registered users via the

  16. Plasma heating, fueling, and maintenance: a technical assessment

    International Nuclear Information System (INIS)

    Cullingford, H.S.

    1978-03-01

    The initial section of the following report describes the goals and approach; the essential results of the survey are overviewed in Section 1.4. Amplifying details are relegated to subsequent sections: certain aspects of the plasma physics and engineering questions that bear on technology requirements for fusion reactors are discussed in Section 2; particularly significant individual technology areas are discussed in Section 3; and requirements and technology considerations are combined in the assessment of Section 4

  17. Advanced solar concentrator mass production, operation, and maintenance cost assessment

    Science.gov (United States)

    Niemeyer, W. A.; Bedard, R. J.; Bell, D. M.

    1981-01-01

    The object of this assessment was to estimate the costs of the preliminary design at: production rates of 100 to 1,000,000 concentrators per year; concentrators per aperture diameters of 5, 10, 11, and 15 meters; and various receiver/power conversion package weights. The design of the cellular glass substrate Advanced Solar Concentrator is presented. The concentrator is an 11 meter diameter, two axis tracking, parabolic dish solar concentrator. The reflective surface of this design consists of inner and outer groups of mirror glass/cellular glass gores.

  18. Conceptual design and assessment of in-service inspection and maintenance of KALIMER

    Energy Technology Data Exchange (ETDEWEB)

    Joo, Young Sang; Kim, Seok Hun; Kim, Jong Bum; Lee, Jae Han [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-05-01

    In the conceptual design stage of KALIMER, the philosophy and methodology of in-service inspection (ISI) and maintenance for the reactor system and components are proposed and described. The ISI and maintenance should be carried out throughout plant life to ensure the structural integrity and safety of KALIMER. The conceptual design of ISI and maintenance are performed for considering the design characteristics of KALIMER and the intents of the ASME XI Division 3. This report describes and summarizes the requirements and available methods of ISI and maintenance. The visual inspection and continuous monitoring play a great role in the in-service inspection of KALIMER. The major structures of KALIMER reactor system are designed for maintenance free operation for the plant life time and the maintenance philosophy is to replace major components rather than repair them. The assessment of the ISI accessibility and maintainability is performed and reviewed each major component. The postulated failure defects for each component are estimated and evaluated for KALIMER safety and reliability. 8 refs., 16 figs., 13 tabs. (Author)

  19. Development of stand-alone risk assessment software for optimized maintenance planning of power plant facilities

    International Nuclear Information System (INIS)

    Choi, Woo Sung; Song, Gee Wook; Kim, Bum Shin; Chang, Sung Ho; Lee, Sang Min

    2015-01-01

    Risk-Risk-based inspection (RBI) has been developed in order to identify risky equipment that can cause major accidents or damages in large-scale plants. This assessment evaluates the equipment's risk, categorizes their priorities based on risk level, and then determines the urgency of their maintenance or allocates maintenance resources. An earlier version of the risk-based assessment software is already installed within the equipment management system; however, the assessment is based on examination by an inspector, and the results can be influenced by his subjective judgment, rather than assessment being based on failure probability. Moreover, the system is housed within a server, which limits the inspector's work space and time, and such a system can be used only on site. In this paper, the development of independent risk-based assessment software is introduced; this software calculates the failure probability by an analytical method, and analyzes the field inspection results, as well as inspection effectiveness. It can also operate on site, since it can be installed on an independent platform, and has the ability to generate an I/O function for the field inspection results regarding the period for an optimum maintenance cycle. This program will provide useful information not only to the field users who are participating in maintenance, but also to the engineers who need to decide whether to extend the life cycle of the power machinery or replace only specific components

  20. A proposed model for assessing service quality in small machining and industrial maintenance companies

    Directory of Open Access Journals (Sweden)

    Morvam dos Santos Netto

    2014-11-01

    Full Text Available Machining and industrial maintenance services include repair (corrective maintenance of equipments, activities involving the assembly-disassembly of equipments, fault diagnosis, machining operations, forming operations, welding processes, assembly and test of equipments. This article proposes a model for assessing the quality of services provided by small machining and industrial maintenance companies, since there is a gap in the literature regarding this issue and because the importance of small service companies in socio-economic development of the country. The model is an adaptation of the SERVQUAL instrument and the criteria determining the quality of services are designed according to the service cycle of a typical small machining and industrial maintenance company. In this sense, the Moments of Truth have been considered in the preparation of two separate questionnaires. The first questionnaire contains 24 statements that reflect the expectations of customers, and the second one contains 24 statements that measure perceptions of service performance. An additional item was included in each questionnaire to assess, respectively, the overall expectation about the services and the overall company performance. Therefore, it is a model that considers the interfaces of the client/supplier relationship, the peculiarities of the machining and industrial maintenance service sector and the company size.

  1. Risk-Based Maintenance Assessment in the Manufacturing Industry: Minimisation of Suboptimal Prioritisation

    Directory of Open Access Journals (Sweden)

    Ratnayake R.M. Chandima

    2017-03-01

    Full Text Available Manufacturing firms continuously strive to increase the efficiency and effectiveness in the maintenance management processes. Focus is placed on eliminating the unexpected failures which cause unnecessary costs and the production losses. Risk-based maintenance (RBM strategies enable to address the above through the identification of probability and consequences of potential failures whilst providing a way for prioritisation of maintenance actions based on the risk of possible failures. Such prioritisations enable to identify the optimal maintenance strategy, intervals of maintenance tasks, and optimal level of spare parts inventory. However, the risk assessment activities are performed with the support of a risk matrix. Suboptimal classifications and/or prioritisations arise due to the inherent nature of the risk matrix. This is caused by the fact that there are no means to incorporate actual circumstances at the boundary of the input ranges or at the levels of linguistic data and risk categories. In this paper, a risk matrix is first developed in collaboration with one of the manufacturing firms in Poland. Then, it illustrates the use of fuzzy logic for minimisation of suboptimal prioritisation and/or classifications using a fuzzy inference system (FIS together with illustrative membership functions and a rule base. Finally, an illustrative risk assessment is also demonstrated to illustrate the methodology.

  2. Rh Factor Blood Test

    Science.gov (United States)

    ... Also, talk with your health care provider about scheduling an Rh immune globulin injection during your pregnancy ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization ...

  3. RH Packaging Operations Manual

    International Nuclear Information System (INIS)

    Washington TRU Solutions LLC

    2003-01-01

    This procedure provides operating instructions for the RH-TRU 72-B Road Cask, Waste Shipping Package. In this document, ''Packaging'' refers to the assembly of components necessary to ensure compliance with the packaging requirements (not loaded with a payload). ''Package'' refers to a Type B packaging that, with its radioactive contents, is designed to retain the integrity of its containment and shielding when subject to the normal conditions of transport and hypothetical accident test conditions set forth in 10 CFR Part 71. Loading of the RH 72-B cask can be done two ways, on the RH cask trailer in the vertical position or by removing the cask from the trailer and loading it in a facility designed for remote-handling (RH). Before loading the 72-B cask, loading procedures and changes to the loading procedures for the 72-B cask must be sent to CBFO at sitedocuments at wipp.ws for approval

  4. Competencies development and self-assessment in maintenance management e-training

    Science.gov (United States)

    Papathanassiou, Nikos; Pistofidis, Petros; Emmanouilidis, Christos

    2013-10-01

    The maintenance management function requires staff to possess a truly multidisciplinary set of skills. This includes competencies from engineering and information technology to health and safety, management and finance, while also taking into account the normative and legislative issues. This body of knowledge is rarely readily available within a single university course. The potential of e-learning in this field is significant, as it is a flexible and less costly alternative to conventional training. Furthermore, trainees can follow their own pace, as their available time is often a commodity. This article discusses the development of tools to support competencies development and self-assessment in maintenance management. Based on requirements arising from professional bodies' guidelines and a user survey, the developed tools implement a dedicated maintenance management training curriculum. The results from pilot testing on academic and industrial user groups are discussed and user evaluations are linked with specific e-learning design issues.

  5. 77 FR 70846 - Regulatory Guide 1.182, “Assessing and Managing Risk Before Maintenance Activities at Nuclear...

    Science.gov (United States)

    2012-11-27

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0285] Regulatory Guide 1.182, ``Assessing and Managing Risk Before Maintenance Activities at Nuclear Power Plants'' AGENCY: Nuclear Regulatory Commission... withdrawing Regulatory Guide (RG)1.182, Revision (Rev.) 0, ``Assessing and Managing Risk Before Maintenance...

  6. The Development and Application of a Value-Driven Aircraft Maintenance Operations Performance Assessment Model combined with Real Options Analysis

    NARCIS (Netherlands)

    Goossens, H.G.; Beelaerts van Blokland, W.W.A.; Curran, R.

    2011-01-01

    This research paper presents the results from the development of an Aircraft Maintenance Operations Performance Assessment Model (AMOPAM). The AMOPAM is able to assess the differences in performance in between two different states or scenarios of aircraft maintenance operations and is able to

  7. Florida maintenance rating program (MRP) assessment and enhancement : final report, May 28, 2008.

    Science.gov (United States)

    2008-05-28

    The Maintenance Rating Program (MRP), developed in 1985 by FDOT, is a statewide maintenance system aimed : at evaluating the State highway maintenance conditions, and determining FDOT asset maintenance needs. In the : quest for continuous improvement...

  8. Risk assessment of maintenance operations: the analysis of performing task and accident mechanism.

    Science.gov (United States)

    Carrillo-Castrillo, Jesús A; Rubio-Romero, Juan Carlos; Guadix, Jose; Onieva, Luis

    2015-01-01

    Maintenance operations cover a great number of occupations. Most small and medium-sized enterprises lack the appropriate information to conduct risk assessments of maintenance operations. The objective of this research is to provide a method based on the concepts of task and accident mechanisms for an initial risk assessment by taking into consideration the prevalence and severity of the maintenance accidents reported. Data were gathered from 11,190 reported accidents in maintenance operations in the manufacturing sector of Andalusia from 2003 to 2012. By using a semi-quantitative methodology, likelihood and severity were evaluated based on the actual distribution of accident mechanisms in each of the tasks. Accident mechanisms and tasks were identified by using those variables included in the European Statistics of Accidents at Work methodology. As main results, the estimated risk of the most frequent accident mechanisms identified for each of the analysed tasks is low and the only accident mechanisms with medium risk are accidents when lifting or pushing with physical stress on the musculoskeletal system in tasks involving carrying, and impacts against objects after slipping or stumbling for tasks involving movements. The prioritisation of public preventive actions for the accident mechanisms with a higher estimated risk is highly recommended.

  9. How and when will self-assessment improve maintenance of CANDU plants - evaluator's view

    International Nuclear Information System (INIS)

    Mika, K.

    1997-01-01

    Learning organizations use self-evaluation programs to compare their actual performance with their management's expectations and industry standards. In general, self-evaluations identify areas needing improvement. Self-evaluation activities in maintenance departments include self-assessments, management monitoring observations, root cause analyses, event investigations, benchmarking, use of operating experience, self-checking, and problem reporting systems. In Ontario Hydro Nuclear (OHN) we have used almost all forms of self-evaluation with mixed success. However, we did not use self-assessments. With emphasis on excellent maintenance this powerful form of self-evaluation is being introduced to all our plants. Because of its recency and relative inexperience with it, this paper is focused on self-assessment. The paper provides the author's perspective on how a self-assessment program would be evaluated by an independent internal evaluation and what attributes should be in place in order for maintenance departments to succeed in the implementation and successful continuation of the program. (author)

  10. Pavement condition assessment to forecast maintenance program on JKR state roads in Petaling district

    Science.gov (United States)

    Hamsan, R.; Hafiz, H.; Azlan, A.; Keprawi, M. F.; Malik, A. K. A.; Adamuddin, A.; Abdullah, A. H.; Shafie, A. M.

    2018-02-01

    This research allows local authorities to project road maintenance in term of activities and financial expenditure through pavement condition assessment and then Highway Development and Management (HDM-4) analysis. Current form of road maintenance carried out by local authority is on reactive manner where corrective actions were taken based on reports recorded. Some went unrecorded hence causing prolonged damages. This causes the local authority unable to project the required cost to maintain the roads. This affects the socio-economy of the surrounding routes. Hence, it is seen, as preventive maintenance of the roads will provide more feasible option in term of work force and finance to the local authority. To overcome this issue, a preventive model was introduced. This was done through pavement condition assessment (PCA) where analysis was done through HDM-4. Nondestructive test and destructive test were conducted in order to provide an indicator to the road's health. This were then analyzed in HDM-4 where the result was benchmarked with maintenance standard. The scope of this research is set to PCA where DT and NDT were performed on the routes of Petaling and the output is analyzed in HDM-4. The result of this research provides a 10 years forecast maintenance budget in maintaining the roads in Petaling. This allows the local authority to perform good practice in term of maintaining the roads while at the same time helps them in forecasting their budget for the upcoming years. This research will have a strong impact on the local socio-economy as well as local road user confidence towards the authority over good practices. This research can be further expanded to other type of roads as well as highway bridges.

  11. Nursing Informatics Competencies: Psychometric Validation, Dissemination, and Maintenance of Self-Assessment Tool for Nurse Leaders.

    Science.gov (United States)

    Collins, Sarah

    2016-01-01

    Due to rapid advances in technology, HIT competencies for nursing leaders require frequent attention and updating from experts in the field to ensure relevance to nursing leaders' work. This workshop will target nursing informatics researchers and leaders to: 1) learn methods and findings from a study validating a Self-Assessment Scale for Nursing Informatics Competencies for Nurse Leaders, 2) generate awareness of the Self-Assessment scale, 3) discuss strategies for maintenance of competencies overtime and 4) identify strategies to engage nursing leaders in this pursuit.

  12. An independent safety assessment of Department of Energy nuclear reactor facilities: Procedures, operations and maintenance

    International Nuclear Information System (INIS)

    Toto, G.; Lindgren, A.J.

    1981-02-01

    The 1979 accident at the Three Mile Island commercial nuclear power plant has led to a number of studies of nuclear reactors, in both the public and private sectors. One of these is that of the Department of Energy's (DOE) Nuclear Facilities Personnel Qualification and Training (NFPQT) Committee, which has outlined tasks for assessment of 13 reactors owned by DOE and operated by contractors. This report covers one of the tasks, the assessment of procedures, operations, and maintenance at the DOE reactor facilities, based on a review of actual documents used at the reactor sites

  13. Probability-based assessment and maintenance of welded joints damaged by fatigue

    International Nuclear Information System (INIS)

    Cremona, C.; Lukic, M.

    1998-01-01

    This paper presents a probabilistic reliability assessment procedure for steel components damaged by fatigue. The study combines the structural reliability theory with a maintenance strategy. The fatigue assessment model is based on a modelisation of the fatigue phenomenon issued from the principles of fracture mechanics theory. The safety margin includes the crack growth propagation and allows to treat fatigue damage in a general manner. Damaging cycles and non damaging cycles are distinguished. The sensitivity study of the different parameters shows that some variables can be taken as deterministic. Applications are made on a welded joint 'stiffener/bottom-plate' of a typical steel bridge. The model is then used for taking into account inspection results. Non destructive inspection (NDI) techniques are also used for updating failure probabilities. The results show their ability to be inserted in a maintenance strategy for optimizing the next inspection time. This has led to define cost functions related to the total maintenance cost; this cost is then minimized for determining the optimal next inspection time. An example of welded joint cracked by fatigue highlights the different concepts. The approach presented in the paper is not only restrained to fatigue problems, but can be applied to a wide variety of degrading phenomena. (orig.)

  14. Florida maintenance rating program (MRP) assessment and enhancement : final report, May 28, 2008 [summary].

    Science.gov (United States)

    2008-01-01

    The Florida Department of Transportation : (FDOT) has used its maintenance rating : program (MRP) to evaluate the states : highway maintenance conditions and : determine asset maintenance needs since : 1985. Periodic evaluation of the program is :...

  15. 78 FR 26383 - Environmental Assessment of the Proposed Increase in Operation, Maintenance and Replacement...

    Science.gov (United States)

    2013-05-06

    ... Proposed Increase in Operation, Maintenance and Replacement Activities Associated With the Wasatch County... of potential impacts associated with a proposed change in Operation, Maintenance and Replacement..., Maintenance, and Replacement Proposed Action includes: stabilizing canal banks; lining, piping, or enclosing...

  16. Radiographic Assessment of Bone Formation Using rhBMP2 at Maxillary Periapical Surgical Defects: A Case Series.

    Science.gov (United States)

    Kumar, M Siva; Kumar, M Hari; Vishalakshi, K; Sabitha, H

    2016-04-01

    Periapical cysts are the most common inflammatory odontogenic cysts arising from untreated dental caries with pulp necrosis and periapical infection. The choice of treatment is often influenced by various factors like size, extension of the lesion, proximity to vital structures, systemic condition and compliance of the patient too. The treatment protocol for management of periapical cysts is still under discussion and options vary from conservative treatment by means of endodontic technique to surgical treatment like decompression or a marsupialisation or even to enucleation. Large bony defect secondary to periapical surgery compromising the tooth integrity often requires bone graft to enhance bone formation and thus restoring function at the earliest. The present case series included 10 patients who had established periapical pathology secondary to history of trauma on upper anterior teeth as well patients with history of carious teeth with an apparent failure in root canal therapy. All ten patients were treated with cyst enucleation and apiceotomy along with 1.4cc Recombinant Human Bone Morphogenetic Protein-2 soaked Absorbable Collagen Sponge implantation at surgical defect. Radiographs and clinical examinations were done upto 3 months to evaluate healing. Radiographic and clinical assessments revealed bone regeneration and restoration of the maxillary surgical defects in all 10 patients. No evidence of graft failure was noted. The Recombinant Human Bone Morphogenetic Protein-2 soaked Absorbable Collagen Sponge carrier is thus proved to be a viable option for the treatment of maxillary periapical surgical defects.

  17. Environmental risk assessment for start-up of a new consolidated maintenance facility

    Energy Technology Data Exchange (ETDEWEB)

    Heubach, J.G.; Wise, J.A.

    1992-10-01

    This paper summarizes a case study of a risk assessment for a consolidated maintenance facility (CMF). An interdisciplinary team was formed to identify and evaluate showstopper'' risks which could delay or prevent ontime, safe, and economical operation of a CMF and to recommend ways to mitigate the risks. The risk assessment was constrained by time, information, incomplete plans and facilities, and a concomitant major transition in manufacturing process, organization, and technology. Working within these constraints, the team integrated convergent findings into estimates of high, medium, and low risks based on the subjective likelihood of occurrence and predicted consequences of potential hazard events. The team also made risk-reduction recommendations for facility detail design and production start-up. The findings and recommendations reported in this study focus on risks related to environmental design and workstation ergonomics. Findings from the risk assessment effort should aid other constrained risk assessments and applied research on similar facilities.

  18. Organizational-economic maintenance of innovation activity in the region: comparative assessment

    Directory of Open Access Journals (Sweden)

    Nadezhda Igorevna Antipina

    2014-05-01

    Full Text Available The article proposes the approach to evaluate the organizational-economic maintenance of innovation activity in the regions in quantitative and qualitative indicators, as well as the method to calculate the assessment of regulatory support of this activity. It justifies the author’s approach of comparative efficiency evaluation of innovation legislation and regions’ innovation development level. The article gives the qualitative estimation of regulatory support of innovation development in the regions that are innovation leaders. It singles out key directions to develop regulatory support of innovation activity, which encourage RF subjects’ innovation activity

  19. Prediction of Maintenance Period of Equipment Through Risk Assessment of Thermal Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Song, Gee Wook; Kim, Bum Shin; Choi, Woo Song; Park, Myung Soo [KEPCO Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    Risk-based inspection (RBI) is a well-known method that is used to optimize inspection activities based on risk analysis in order to identify the high-risk components of major facilities such as power plants. RBI, when implemented and maintained properly, improves plant reliability and safety while reducing unplanned outages and repair costs. Risk is given by the product of the probability of failure (Pof) and the consequence of failure (COF). A semi-quantitative method is generally used for risk assessment. Semi-quantitative risk assessment complements the low accuracy of qualitative risk assessment and the high expense and long calculation time of quantitative risk assessment. The first step of RB I is to identify important failure modes and causes in the equipment. Once these are defined, the Pof and COF can be assessed for each failure. During Pof and COF assessment, an effective inspection method and range can be easily found. In this paper, the calculation of the Pof is improved for accurate risk assessment. A modified semi-quantitative risk assessment was carried out for boiler facilities of thermal power plants, and the next maintenance schedules for the equipment were decided.

  20. Prediction of Maintenance Period of Equipment Through Risk Assessment of Thermal Power Plants

    International Nuclear Information System (INIS)

    Song, Gee Wook; Kim, Bum Shin; Choi, Woo Song; Park, Myung Soo

    2013-01-01

    Risk-based inspection (RBI) is a well-known method that is used to optimize inspection activities based on risk analysis in order to identify the high-risk components of major facilities such as power plants. RBI, when implemented and maintained properly, improves plant reliability and safety while reducing unplanned outages and repair costs. Risk is given by the product of the probability of failure (Pof) and the consequence of failure (COF). A semi-quantitative method is generally used for risk assessment. Semi-quantitative risk assessment complements the low accuracy of qualitative risk assessment and the high expense and long calculation time of quantitative risk assessment. The first step of RB I is to identify important failure modes and causes in the equipment. Once these are defined, the Pof and COF can be assessed for each failure. During Pof and COF assessment, an effective inspection method and range can be easily found. In this paper, the calculation of the Pof is improved for accurate risk assessment. A modified semi-quantitative risk assessment was carried out for boiler facilities of thermal power plants, and the next maintenance schedules for the equipment were decided

  1. Industry comparison through systematic self assessment of the maintenance function of each operation company of the Norwegian continental shelf

    International Nuclear Information System (INIS)

    Nielsen, L.

    2000-01-01

    In this paper The Norwegian Petroleum Directorate (NPD) will describe a method for internal evaluation or self-assessment of the maintenance function of each operating oil company in the Norwegian offshore petroleum industry. Due to the current trends of cost reduction, demanning and downsizing, the industry has started to use RCM and other risk based maintenance techniques. Judged by the experience gained so far in this industry, the successful implementation of RCM and other risk based maintenance optimisation techniques seems to be closely linked with the existence of a efficient and professional maintenance management system. NPD is therefore now developing a guideline for systematic self-assessment of the maintenance function and the maintenance management system. The guideline has been developed based on a method developed by SKI. NPD has in close co-operation with the industry adapted SKI's guideline to fit the problems and challenges of the petroleum industry. It is NPD's intention to highlight different strategic, organisational and administrative issues linked with the introduction of risk based maintenance methods in the guideline. NPD also try to reflect 'best practices' in the industry in the guideline in order to provoke the oil companies to review their own practices in different areas. The results so far from using this method for self-assessment will be presented, and both the advantages and disadvantages of such an approach will be discussed. (author)

  2. Atomic Energy Control Board (AECB) staff assessment and views of current maintenance practices of a four unit CANDU plant

    International Nuclear Information System (INIS)

    Malek, I.

    1995-01-01

    This paper discusses the AECB practices in assessing maintenance activities at one four unit CANDU nuclear plant.-it outlines the authority of the AECB in enforcing the licence condition concerned with maintenance, and how this is interpreted by AECB site staff to measure and report maintenance activities. The AECB staff attaches great importance to proper maintenance as it affects safe operation. Programs used by the licensee staff to identify safety important components, or to predict degradations and failures are of particular interest. In our experience, the application of such programs has been generally good. However, their integration into an overall maintenance scheme can be improved, and the possibilities of integration are not well understood. This paper includes examples of such integration to illustrate our views and to highlight the resultant benefits that AECB staff believes are possible. (author)

  3. An integrated architecture for the ITER RH control system

    International Nuclear Information System (INIS)

    Hamilton, David Thomas; Tesini, Alessandro

    2012-01-01

    Highlights: ► Control system architecture integrating ITER remote handling equipment systems. ► Standard control system architecture for remote handling equipment systems. ► Research and development activities to validate control system architecture. ► Standardization studies to select standard parts for control system architecture. - Abstract: The ITER remote handling (RH) system has been divided into 7 major equipment system procurements that deliver complete systems (operator interfaces, equipment controllers, and equipment) according to task oriented functional specifications. Each equipment system itself is an assembly of transporters, power manipulators, telemanipulators, vehicular systems, cameras, and tooling with a need for controllers and operator interfaces. From an operational perspective, the ITER RH systems are bound together by common control rooms, operations team, and maintenance team; and will need to achieve, to a varying degree, synchronization of operations, co-operation on tasks, hand-over of components, and sharing of data and resources. The separately procured RH systems must, therefore, be integrated to form a unified RH system for operation from the RH control rooms. The RH system will contain a heterogeneous mix of specially developed RH systems and off-the-shelf RH equipment and parts. The ITER Organization approach is to define a control system architecture that supports interoperable heterogeneous modules, and to specify a standard set of modules for each system to implement within this architecture. Compatibility with standard parts for selected modules is required to limit the complexity for operations and maintenance. A key requirement for integrating the control system modules is interoperability, and no module should have dependencies on the implementation details of other modules. The RH system is one of the ITER Plant systems that are integrated and coordinated through the hierarchical structure of the ITER CODAC system

  4. EPRI steam turbine and generator NDE, life assessment, and maintenance workshop

    International Nuclear Information System (INIS)

    Nottingham, L.D.; Sabourin, P.F.

    1992-10-01

    On July 16--19, 1991, the EPRI NDE Center hosted the second EPRI Steam Turbine and Generator NDE, Life Assessment and Maintenance Workshop. This workshop was co-sponsored by the Nuclear Power and the Generation and Storage Divisions of EPRI. Attendees represented all sectors of the industry including utilities, equipment manufacturers, forging suppliers, service organizations, government organizations, insurancecarriers, and consultants from the United States and abroad. Domestic utility presence was again strong, with 105 representatives from 44 utilities in attendance. Australia, Canada, England, Finland, France, Germany, Italy, Japan, Korea, New Zealand, Spain, Sweden and Switzerland were represented in the international contingent. A key and integral part of the workshop was a vendor equipment fair, in which some 23 organizations displayed and demonstrated equipment and services that they offer. Formal presentation of 53 technical papers made up the technical portion of the agenda, which also included two breakout discussion sessions on topical subjects. To provide optimum opportunity for participants to hear all presentations on closely related topics, the sessions were set such that a NDE session ran parallel to the life assessment session. The first NDE session included turbine related topics while the first life assessment session addressed generator issues. The last sessions of the workshop were just reversed with turbine topics being addressed in the life assessment session while generator issues were presented in the NDE session. Presentations on maintenance topics and on monitoring and diagnostics topics were also presented in parallel sessions. These proceedings contain the texts of the papers presented at the workshop. Individual papers in indexed separately

  5. CoFeRh alloys

    Energy Technology Data Exchange (ETDEWEB)

    Tabakovic, Ibro [Seagate Technology, Research and Development, Bloomington, MN 55435 (United States)], E-mail: ibro.m.tabakovic@seagate.com; Qiu Jiaoming; Riemer, Steve; Sun Ming; Vas' ko, Vlad; Kief, Mark [Seagate Technology, Research and Development, Bloomington, MN 55435 (United States)

    2008-01-01

    The electrochemical behavior of Rh(III) species in CoFe solution containing RhCl{sub 3}, NH{sub 4}Cl, H{sub 3}BO{sub 3}, CoSO{sub 4}, FeSO{sub 4}, saccharin, and NaLS (Na lauryl sulfate) has been investigated. The electrochemistry of Rh(III) species is influenced by each of the compounds present in CoFe plating solution, but especially by addition of saccharin and H{sub 3}BO{sub 3} to the RhCl{sub 3}-NH{sub 4}Cl solution. The nucleation and growth of Rh on GC (glassy carbon), Ru, and Cu electrodes from NH{sub 4}Cl solution was studied using the potentiostatic current-transient methods. The results support a predominantly progressive nucleation of Rh on all three-electrode surfaces. The nucleation kinetic parameters ANo (steady state nucleation rate) and Ns (saturation nuclear number density) were found to vary with potential and are electrode-dependent in order: GC > Ru{approx}Cu. The electrodeposited Rh films obtained from NH{sub 4}Cl solution and nonmagnetic CoFeRh film obtained from CoFe solution were characterized in terms of the following properties: morphology, surface roughness, crystal structure and chemical composition. The origin of light elements found in Rh and CoFeRh films (O, Cl, S, C, N) was discussed.

  6. CoFeRh alloys

    International Nuclear Information System (INIS)

    Tabakovic, Ibro; Qiu Jiaoming; Riemer, Steve; Sun Ming; Vas'ko, Vlad; Kief, Mark

    2008-01-01

    The electrochemical behavior of Rh(III) species in CoFe solution containing RhCl 3 , NH 4 Cl, H 3 BO 3 , CoSO 4 , FeSO 4 , saccharin, and NaLS (Na lauryl sulfate) has been investigated. The electrochemistry of Rh(III) species is influenced by each of the compounds present in CoFe plating solution, but especially by addition of saccharin and H 3 BO 3 to the RhCl 3 -NH 4 Cl solution. The nucleation and growth of Rh on GC (glassy carbon), Ru, and Cu electrodes from NH 4 Cl solution was studied using the potentiostatic current-transient methods. The results support a predominantly progressive nucleation of Rh on all three-electrode surfaces. The nucleation kinetic parameters ANo (steady state nucleation rate) and Ns (saturation nuclear number density) were found to vary with potential and are electrode-dependent in order: GC > Ru∼Cu. The electrodeposited Rh films obtained from NH 4 Cl solution and nonmagnetic CoFeRh film obtained from CoFe solution were characterized in terms of the following properties: morphology, surface roughness, crystal structure and chemical composition. The origin of light elements found in Rh and CoFeRh films (O, Cl, S, C, N) was discussed

  7. Continuing competence assessment and maintenance in occupational therapy: Scoping review with stakeholder consultation.

    Science.gov (United States)

    Myers, Christine T; Schaefer, Nancy; Coudron, Ashley

    2017-12-01

    Continuing competence activities hold the promise of improving health-care service quality, especially given concerns about system inefficiencies and fragmentation. The aim of this scoping review was to describe the assessment and maintenance of occupational therapists' continuing competence and identify knowledge gaps for future research. A secondary aim was comparing scoping review findings with those from other health-care fields and considering possible impact of varying international regulations. A series of database searches retrieved peer-reviewed and grey literature on assessment and maintenance of occupational therapy continuing competence from 1995 to 2015. Themes were developed and findings shared with stakeholders, whose comments drove a second phase: searching for reviews related to continuing competence from allied health, medicine, and nursing, and reviewing websites and documents concerning regulatory requirements for occupational therapy continuing competence in seven English-speaking nations. Twenty-seven sources from the scoping review search met inclusion criteria. Stakeholder consultation validated the themes and preliminary knowledge gaps. Research into other health-care specialties corresponded to findings from the scoping review. The website/document review of occupational therapy regulatory requirements revealed wide variation on both the state/province and national levels. This scoping review highlights gaps in research on effective methods and assessment of occupational therapy continuing competence. Findings suggest a need for research on approaches to continuing competence that incorporate the translation of evidence to practice and address the influence of external factors. Regulatory agencies may address the quality of occupational therapy services by incorporating a variety of professional development options into requirements. © 2017 Occupational Therapy Australia.

  8. RH-TRU Waste Content Codes (RH-TRUCON)

    International Nuclear Information System (INIS)

    2007-01-01

    The Remote-Handled Transuranic (RH-TRU) Content Codes (RH-TRUCON) document describes the inventory of RH-TRU waste within the transportation parameters specified by the Remote-Handled Transuranic Waste Authorized Methods for Payload Control (RH-TRAMPAC).1 The RH-TRAMPAC defines the allowable payload for the RH-TRU 72-B. This document is a catalog of RH-TRU 72-B authorized contents by site. A content code is defined by the following components: A two-letter site abbreviation that designates the physical location of the generated/stored waste (e.g., ID for Idaho National Laboratory [INL]). The site-specific letter designations for each of the sites are provided in Table 1. A three-digit code that designates the physical and chemical form of the waste (e.g., content code 317 denotes TRU Metal Waste). For RH-TRU waste to be transported in the RH-TRU 72-B, the first number of this three-digit code is '3.' The second and third numbers of the three-digit code describe the physical and chemical form of the waste. Table 2 provides a brief description of each generic code. Content codes are further defined as subcodes by an alpha trailer after the three-digit code to allow segregation of wastes that differ in one or more parameter(s). For example, the alpha trailers of the subcodes ID 322A and ID 322B may be used to differentiate between waste packaging configurations. As detailed in the RH-TRAMPAC, compliance with flammable gas limits may be demonstrated through the evaluation of compliance with either a decay heat limit or flammable gas generation rate (FGGR) limit per container specified in approved content codes. As applicable, if a container meets the watt*year criteria specified by the RH-TRAMPAC, the decay heat limits based on the dose-dependent G value may be used as specified in an approved content code. If a site implements the administrative controls outlined in the RH-TRAMPAC and Appendix 2.4 of the RH-TRU Payload Appendices, the decay heat or FGGR limits based

  9. RH-TRU Waste Content Codes (RH-TRUCON)

    Energy Technology Data Exchange (ETDEWEB)

    Washington TRU Solutions LLC

    2007-08-01

    The Remote-Handled Transuranic (RH-TRU) Content Codes (RH-TRUCON) document describes the inventory of RH-TRU waste within the transportation parameters specified by the Remote-Handled Transuranic Waste Authorized Methods for Payload Control (RH-TRAMPAC).1 The RH-TRAMPAC defines the allowable payload for the RH-TRU 72-B. This document is a catalog of RH-TRU 72-B authorized contents by site. A content code is defined by the following components: • A two-letter site abbreviation that designates the physical location of the generated/stored waste (e.g., ID for Idaho National Laboratory [INL]). The site-specific letter designations for each of the sites are provided in Table 1. • A three-digit code that designates the physical and chemical form of the waste (e.g., content code 317 denotes TRU Metal Waste). For RH-TRU waste to be transported in the RH-TRU 72-B, the first number of this three-digit code is “3.” The second and third numbers of the three-digit code describe the physical and chemical form of the waste. Table 2 provides a brief description of each generic code. Content codes are further defined as subcodes by an alpha trailer after the three-digit code to allow segregation of wastes that differ in one or more parameter(s). For example, the alpha trailers of the subcodes ID 322A and ID 322B may be used to differentiate between waste packaging configurations. As detailed in the RH-TRAMPAC, compliance with flammable gas limits may be demonstrated through the evaluation of compliance with either a decay heat limit or flammable gas generation rate (FGGR) limit per container specified in approved content codes. As applicable, if a container meets the watt*year criteria specified by the RH-TRAMPAC, the decay heat limits based on the dose-dependent G value may be used as specified in an approved content code. If a site implements the administrative controls outlined in the RH-TRAMPAC and Appendix 2.4 of the RH-TRU Payload Appendices, the decay heat or FGGR

  10. RH-TRU Waste Content Codes (RH-TRUCON)

    Energy Technology Data Exchange (ETDEWEB)

    Washington TRU Solutions

    2007-05-30

    The Remote-Handled Transuranic (RH-TRU) Content Codes (RH-TRUCON) document describes the inventory of RH-TRU waste within the transportation parameters specified by the Remote-Handled Transuranic Waste Authorized Methods for Payload Control (RH-TRAMPAC).1 The RH-TRAMPAC defines the allowable payload for the RH-TRU 72-B. This document is a catalog of RH-TRU 72-B authorized contents by site. A content code is defined by the following components: • A two-letter site abbreviation that designates the physical location of the generated/stored waste (e.g., ID for Idaho National Laboratory [INL]). The site-specific letter designations for each of the sites are provided in Table 1. • A three-digit code that designates the physical and chemical form of the waste (e.g., content code 317 denotes TRU Metal Waste). For RH-TRU waste to be transported in the RH-TRU 72-B, the first number of this three-digit code is “3.” The second and third numbers of the three-digit code describe the physical and chemical form of the waste. Table 2 provides a brief description of each generic code. Content codes are further defined as subcodes by an alpha trailer after the three-digit code to allow segregation of wastes that differ in one or more parameter(s). For example, the alpha trailers of the subcodes ID 322A and ID 322B may be used to differentiate between waste packaging configurations. As detailed in the RH-TRAMPAC, compliance with flammable gas limits may be demonstrated through the evaluation of compliance with either a decay heat limit or flammable gas generation rate (FGGR) limit per container specified in approved content codes. As applicable, if a container meets the watt*year criteria specified by the RH-TRAMPAC, the decay heat limits based on the dose-dependent G value may be used as specified in an approved content code. If a site implements the administrative controls outlined in the RH-TRAMPAC and Appendix 2.4 of the RH-TRU Payload Appendices, the decay heat or FGGR

  11. RH-TRU Waste Content Codes (RH-Trucon)

    International Nuclear Information System (INIS)

    2007-01-01

    The Remote-Handled Transuranic (RH-TRU) Content Codes (RH-TRUCON) document describes the inventory of RH-TRU waste within the transportation parameters specified by the Remote-Handled Transuranic Waste Authorized Methods for Payload Control (RH-TRAMPAC).1 The RH-TRAMPAC defines the allowable payload for the RH-TRU 72-B. This document is a catalog of RH-TRU 72-B authorized contents by site. A content code is defined by the following components: A two-letter site abbreviation that designates the physical location of the generated/stored waste (e.g., ID for Idaho National Laboratory [INL]). The site-specific letter designations for each of the sites are provided in Table 1. A three-digit code that designates the physical and chemical form of the waste (e.g., content code 317 denotes TRU Metal Waste). For RH-TRU waste to be transported in the RH-TRU 72-B, the first number of this three-digit code is '3.' The second and third numbers of the three-digit code describe the physical and chemical form of the waste. Table 2 provides a brief description of each generic code. Content codes are further defined as subcodes by an alpha trailer after the three-digit code to allow segregation of wastes that differ in one or more parameter(s). For example, the alpha trailers of the subcodes ID 322A and ID 322B may be used to differentiate between waste packaging configurations. As detailed in the RH-TRAMPAC, compliance with flammable gas limits may be demonstrated through the evaluation of compliance with either a decay heat limit or flammable gas generation rate (FGGR) limit per container specified in approved content codes. As applicable, if a container meets the watt*year criteria specified by the RH-TRAMPAC, the decay heat limits based on the dose-dependent G value may be used as specified in an approved content code. If a site implements the administrative controls outlined in the RH-TRAMPAC and Appendix 2.4 of the RH-TRU Payload Appendices, the decay heat or FGGR limits based

  12. Observational Study to Assess the Therapeutic Value of Four Ovarian Hyperstimulation Protocols in IVF After Pituitary Suppression with GnRH Antagonists in Normally Responding Women.

    Science.gov (United States)

    Ana, Monzó; Vicente, Montañana; María, Rubio José; Trinidad, García-Gimeno; Alberto, Romeu

    2011-02-22

    To compare the clinical results of four different protocols of COH for IVF-ICSI in normovulatory women, using in all cases pituitary suppression with GnRH antagonists. A single center, open label, parallel-controlled, prospective, post-authorization study under the approved conditions for use where 305 normal responders women who were candidates to COH were assigned to r-FSH +hp-hMG (n = 51, Group I), hp-hMG (n = 61, Group II), fixed-dose r-FSH (n = 118, Group III), and r-FSH with potential dose adjustment (n = 75, Group IV) to subsequently undergo IVF-ICSI. During stimulation, Group IV needed significantly more days of stimulation as compared to Group II [8.09 ± 1.25 vs. 7.62 ± 1.17; P women undergoing pituitary suppression with GnRH antagonists.

  13. Assessment of remote maintenance technologies and their potential application in the Federal Waste Management System [FWMS

    International Nuclear Information System (INIS)

    Kring, C.T.; Meacham, S.A.; Peishel, F.L.

    1988-10-01

    The 40 plus years of remote operating experience in nuclear facilities are summarized, with emphasis on the evolution and capabilities of the remote systems. Current commercially available systems and major development activities are described. The advanced servomanipulator is described, which represents new remote technology that has been developed for the Department of Energy-Nuclear Energy and that can significantly improve remote operations by extending the range of admissible remote tasks and increasing remote work efficiency. Also based upon past ORNL experience with remote facilities for reprocessing fuel, the guidelines and concepts that are utilized in the design, fabrication, and remote operation of mechanical process equipment and facilities are outlined. The currently available remote handling systems that can be applied, in various combinations, to large-volume in-cell operations are described, and requirements for waste storage facilities are reviewed. A basic trade-off analysis of these remote systems considering waste plant requirements is given. Justification is given for selecting the overhead crane/servomanipulator-based maintenance concept as the option most desirable for future waste processing plant in-cell maintenance. The Robotics/Remote Handling workshop that was implemented by the Office of Storage and Transportation System during the period that this assessment was being performed, helped focus the remaining time allocated to this effort on the future implementation of an overall program plan using a total systems approach. The concluding recommendation of this assessment is that this Robotics/Remote Handling program plan be developed and implemented as soon as possible. 43 refs., 17 figs., 9 tabs

  14. Assessment of remote maintenance technologies and their potential application in the Federal Waste Management System (FWMS)

    Energy Technology Data Exchange (ETDEWEB)

    Kring, C.T.; Meacham, S.A.; Peishel, F.L.

    1988-10-01

    The 40 plus years of remote operating experience in nuclear facilities are summarized, with emphasis on the evolution and capabilities of the remote systems. Current commercially available systems and major development activities are described. The advanced servomanipulator is described, which represents new remote technology that has been developed for the Department of Energy-Nuclear Energy and that can significantly improve remote operations by extending the range of admissible remote tasks and increasing remote work efficiency. Also based upon past ORNL experience with remote facilities for reprocessing fuel, the guidelines and concepts that are utilized in the design, fabrication, and remote operation of mechanical process equipment and facilities are outlined. The currently available remote handling systems that can be applied, in various combinations, to large-volume in-cell operations are described, and requirements for waste storage facilities are reviewed. A basic trade-off analysis of these remote systems considering waste plant requirements is given. Justification is given for selecting the overhead crane/servomanipulator-based maintenance concept as the option most desirable for future waste processing plant in-cell maintenance. The Robotics/Remote Handling workshop that was implemented by the Office of Storage and Transportation System during the period that this assessment was being performed, helped focus the remaining time allocated to this effort on the future implementation of an overall program plan using a total systems approach. The concluding recommendation of this assessment is that this Robotics/Remote Handling program plan be developed and implemented as soon as possible. 43 refs., 17 figs., 9 tabs.

  15. A durability model incorporating safe life methodology and damage tolerance approach to assess first inspection and maintenance period for structures

    International Nuclear Information System (INIS)

    Xiong, J.J.; Shenoi, R.A.

    2009-01-01

    This paper outlines a new durability model to assess the first inspection and maintenance period for structures. Practical scatter factor formulae are presented to determine the safe fatigue crack initiation and propagation lives from the results of a single full-scale test of a complete structure. New theoretical solutions are proposed to determine the s a -s m -N surfaces of fatigue crack initiation and propagation. Prediction techniques are then developed to establish the relationship equation between safe fatigue crack initiation and propagation lives with a specific reliability level using a two-stage fatigue damage cumulative rule. A new durability model incorporating safe life and damage tolerance design approaches is derived to assess the first inspection and maintenance period. Finally, the proposed models are applied to assess the first inspection and maintenance period of a fastening structure at the root of helicopter blade.

  16. A durability model incorporating safe life methodology and damage tolerance approach to assess first inspection and maintenance period for structures

    Energy Technology Data Exchange (ETDEWEB)

    Xiong, J.J. [Aircraft Department, Beihang University, Beijing 100083 (China); Shenoi, R.A. [School of Engineering Sciences, University of Southampton, Southampton SO17 1BJ (United Kingdom)], E-mail: r.a.shenoi@ship.soton.ac.uk

    2009-08-15

    This paper outlines a new durability model to assess the first inspection and maintenance period for structures. Practical scatter factor formulae are presented to determine the safe fatigue crack initiation and propagation lives from the results of a single full-scale test of a complete structure. New theoretical solutions are proposed to determine the s{sub a}-s{sub m}-N surfaces of fatigue crack initiation and propagation. Prediction techniques are then developed to establish the relationship equation between safe fatigue crack initiation and propagation lives with a specific reliability level using a two-stage fatigue damage cumulative rule. A new durability model incorporating safe life and damage tolerance design approaches is derived to assess the first inspection and maintenance period. Finally, the proposed models are applied to assess the first inspection and maintenance period of a fastening structure at the root of helicopter blade.

  17. Structure and catalytic reactivity of Rh oxides

    DEFF Research Database (Denmark)

    Gustafson, J.; Westerström, R.; Resta, A.

    2009-01-01

    Using a combination of experimental and theoretical techniques, we show that a thin RhO2 surface oxide film forms prior to the bulk Rh2O3 corundum oxide on all close-packed single crystal Rh surfaces. Based on previous reports, we argue that the RhO2 surface oxide also forms on vicinal Rh surface...

  18. Maintenance and life assessment of steam generators at Embalse Nuclear Station

    International Nuclear Information System (INIS)

    Luna, P.; Diaz, G.; Sveruga, H.; Sainz, R.

    2006-01-01

    The Embalse Nuclear Generating Station (ENGS) has four vertical I-800 U-tubes Steam Generators (SGs) manufactured by Babcock and Wilcox (B and W). They are one of the most important components from the point of view of safety and cost-related elements for potential life extensions in case of a replacement thereof. A Life Management program has been started covering the entire plant and starting with the Life Assessment (LA) of this component which consists in a systematic way to evaluate aging mechanisms focused on the plant refurbishment and life extension. Because of this, maintenance-based ageing assessment from beginning of operation is analyzed and current LA-frame maintenance and inspections programs are carried out in order to maintain a high availability of the SGs then to enable the planning for the plant life extension. The most important taken actions have been the Eddy Current (EC) In Service Inspection program which performs 100% of the tubes of two SG every 1.5 years started in 1992, the mechanical cleaning by blasting of the internal tube surface, the sludge removal from the secondary side tubesheet, the divider plate replacement, the installation of antivibration bars (AVB's), installation of TSP inspection ports and an exhaustive inspection of the secondary internals as a preliminary result of the Life Assessment started during early 2000. The most relevant aging mechanism up to 2004 was the Flow Accelerated Corrosion (FAC) of U-bend supports and consequent fretting of tubes. The eddy current inspections allowed the fretting degradation to be detected and mitigated by installing AVB's. Currently, efficiency of this mitigating action is being performed by vibration measurements and visual inspections. However, other degradation mechanism that could have origin due to the U-bend FAC like loose part damage (LPD) is being to be analyzed since could be an issue in the future. At present, FAC degradation on the cold leg side and sludge deposition on the

  19. RH-TRU Waste Content Codes (RH TRUCON)

    International Nuclear Information System (INIS)

    2007-01-01

    The Remote-Handled Transuranic (RH-TRU) Content Codes (RH-TRUCON) document describes the inventory of RH-TRU waste within the transportation parameters specified by the Remote-Handled Transuranic Waste Authorized Methods for Payload Control (RH-TRAMPAC).1 The RH-TRAMPAC defines the allowable payload for the RH-TRU 72-B. This document is a catalog of RH-TRU 72-B authorized contents by site. A content code is defined by the following components: (1) A two-letter site abbreviation that designates the physical location of the generated/stored waste (e.g., ID for Idaho National Laboratory [INL]). The site-specific letter designations for each of the sites are provided in Table 1. (2) A three-digit code that designates the physical and chemical form of the waste (e.g., content code 317 denotes TRU Metal Waste). For RH-TRU waste to be transported in the RH-TRU 72-B, the first number of this three-digit code is ''3''. The second and third numbers of the three-digit code describe the physical and chemical form of the waste. Table 2 provides a brief description of each generic code. Content codes are further defined as subcodes by an alpha trailer after the three-digit code to allow segregation of wastes that differ in one or more parameter(s). For example, the alpha trailers of the subcodes ID 322A and ID 322B may be used to differentiate between waste packaging configurations. As detailed in the RH-TRAMPAC, compliance with flammable gas limits may be demonstrated through the evaluation of compliance with either a decay heat limit or flammable gas generation rate (FGGR) limit per container specified in approved content codes. As applicable, if a container meets the watt*year criteria specified by the RH-TRAMPAC, the decay heat limits based on the dose-dependent G value may be used as specified in an approved content code. If a site implements the administrative controls outlined in the RH-TRAMPAC and Appendix 2.4 of the RH-TRU Payload Appendices, the decay heat or FGGR

  20. RH-TRU Waste Content Codes (RH TRUCON)

    Energy Technology Data Exchange (ETDEWEB)

    Washington TRU Solutions

    2007-05-01

    The Remote-Handled Transuranic (RH-TRU) Content Codes (RH-TRUCON) document describes the inventory of RH-TRU waste within the transportation parameters specified by the Remote-Handled Transuranic Waste Authorized Methods for Payload Control (RH-TRAMPAC).1 The RH-TRAMPAC defines the allowable payload for the RH-TRU 72-B. This document is a catalog of RH-TRU 72-B authorized contents by site. A content code is defined by the following components: • A two-letter site abbreviation that designates the physical location of the generated/stored waste (e.g., ID for Idaho National Laboratory [INL]). The site-specific letter designations for each of the sites are provided in Table 1. • A three-digit code that designates the physical and chemical form of the waste (e.g., content code 317 denotes TRU Metal Waste). For RH-TRU waste to be transported in the RH-TRU 72-B, the first number of this three-digit code is “3.” The second and third numbers of the three-digit code describe the physical and chemical form of the waste. Table 2 provides a brief description of each generic code. Content codes are further defined as subcodes by an alpha trailer after the three-digit code to allow segregation of wastes that differ in one or more parameter(s). For example, the alpha trailers of the subcodes ID 322A and ID 322B may be used to differentiate between waste packaging configurations. As detailed in the RH-TRAMPAC, compliance with flammable gas limits may be demonstrated through the evaluation of compliance with either a decay heat limit or flammable gas generation rate (FGGR) limit per container specified in approved content codes. As applicable, if a container meets the watt*year criteria specified by the RH-TRAMPAC, the decay heat limits based on the dose-dependent G value may be used as specified in an approved content code. If a site implements the administrative controls outlined in the RH-TRAMPAC and Appendix 2.4 of the RH-TRU Payload Appendices, the decay heat or FGGR

  1. Performance Assessment of Maintenance Practices in Government Office Buildings: Case Study of Parcel E, Putrajaya

    Directory of Open Access Journals (Sweden)

    Awg Husaini A.I.

    2014-03-01

    Full Text Available Building maintenance practices must be taken into consideration by building facility managers or building owners. They involve daily operations to ensure that end users can work or live comfortably and safely. Through effective maintenance practices, the functions of the existing building facilities can be maintained and meet the needs of the building users. Maintenance practices must be effective in aspects such as planning, organization and supervision in order to maintain the building at a satisfactory level of performance all the time. A study was conducted on a Federal government office building in Parcel E, Putrajaya to determine the maintenance aspects of the management of the facility. To achieve the objectives of this study a questionnaire survey was used to obtain the required data. The outcomes indicate that the aspects of building maintenance practice and the effectiveness of the maintenance management in government office buildings can influence the satisfaction of the end user. However, some aspects of the current building maintenance practices seem to need improvements in order to enhance the building maintenance management. The recommendations of this study will help in the effective management of the facility and maintenance management practices.

  2. Remote assembly and maintenance of fusion reactors

    International Nuclear Information System (INIS)

    Becquet, M.C.; Farfaletti-Casali, F.

    1991-01-01

    This paper intend to present the state of the art in the field of remote assembly and maintenance, including system analysis design and operation for controlled fusion device such as JET, and the next NET and ITER reactors. The operational constraints of fusion reactors with respect to temperature, radiations dose rates and cumulated doses are considered with the resulting design requirements. Concepts like articulated boom, in-vessel vehicle and blanket handling device are presented. The close relations between computer simulations and experimental validation of those concepts are emphasized to ensure reliability of the operational behavior. Mockups and prototypes in reduced and full scale, as operating machines are described to illustrate the progress in remote operations for fusion reactors. The developments achieved at the Institute for System Engineering and Informatics of the Joint Research Center, in the field of remote blanket maintenance, reliability assessment of RH systems and remote cut and welding of lips joints are considered. (author)

  3. Observational Study to Assess the Therapeutic Value of Four Ovarian Hyperstimulation Protocols in IVF After Pituitary Suppression with GnRH Antagonists in Normally Responding Women

    OpenAIRE

    Ana, Monzó; Vicente, Montañana; María, Rubio José; Trinidad, García-Gimeno; Alberto, Romeu

    2011-01-01

    Objective To compare the clinical results of four different protocols of COH for IVF-ICSI in normovulatory women, using in all cases pituitary suppression with GnRH antagonists. Materials/methods A single center, open label, parallel-controlled, prospective, post-authorization study under the approved conditions for use where 305 normal responders women who were candidates to COH were assigned to r-FSH + hp-hMG (n = 51, Group I), hp-hMG (n = 61, Group II), fixed-dose r-FSH (n = 118, Group III...

  4. Assessment and Evaluation Report on a Pilot Project on Preventive School Maintenance in Eritrea

    DEFF Research Database (Denmark)

    Vagnby, Bo Hellisen

    In 2002, efforts started on formulating a maintenance policy for schools and other social service facilities in Eritrea. Since then, an appropriate policy and related implementation strategies have been further developed. In 2003, a specific pilot project was designed covering a number of schools...... of a school based approach to school maintenance are presented in the report....

  5. PRM-based patterns for knowledge formalisation of industrial systems to support maintenance strategies assessment

    International Nuclear Information System (INIS)

    Medina-Oliva, G.; Weber, P.; Iung, B.

    2013-01-01

    The production system and its maintenance system must be now developed on “system thinking” paradigm in order to guarantee that Key Performance Indicators (KPI) will be optimized all along the production system (operation) life. In a recursive way, maintenance system engineering has to integrate also KPI considerations with regards to its own enabling systems. Thus this paper develops a system-based methodology wherein a set of KPIs is computed in order to verify if the objectives of the production and maintenance systems are satisfied. In order to help the decision-making process for maintenance managers, a “unified” generic model have been developed. This model integrates (a) the interactions of the maintenance system with its enabling systems, (b) the impact of the maintenance strategies through the computation of some key performance indicators, and (c) different kinds of knowledge regarding the maintenance system and the system of interest, including quantitative and qualitative knowledge. This methodology is based on an executable unified model built with Probabilistic Relational Model (PRM). PRM allows a modular representation and inferences computation of large size models. The methodology added-value is shown on a test-bench

  6. Environmental Assessment for Waterfront Facilities Maintenance and Improvements, Pearl Harbor Naval Complex, Oahu, Hawaii

    National Research Council Canada - National Science Library

    2005-01-01

    Commander, Navy Region Hawaii (CNRH) proposes to repair, maintain, and improve waterfront berthing and maintenance facilities for ships and submarines on an as-needed basis within the Pearl Harbor Naval Complex (PHNC...

  7. Observational Study to Assess the Therapeutic Value of Four Ovarian Hyperstimulation Protocols in IVF after Pituitary Suppression with GnRH Antagonists in Normally Responding Women

    Directory of Open Access Journals (Sweden)

    Monzó Ana

    2011-01-01

    Full Text Available Objective To compare the clinical results of four different protocols of COH for IVF-ICSI in normovulatory women, using in all cases pituitary suppression with GnRH antagonists. Materials/methods A single center, open label, parallel-controlled, prospective, post-authorization study under the approved conditions for use where 305 normal responders women who were candidates to COH were assigned to r-FSH + hp-hMG (n = 51, Group I, hp-hMG (n = 61, Group II, fixed-dose r-FSH (n = 118, Group III, and r-FSH with potential dose adjustment (n = 75, Group IV to subsequently undergo IVF-ICSI. Results During stimulation, Group IV needed significantly more days of stimulation as compared to Group II [8.09 ± 1.25 vs. 7.62 ± 1.17; P < 0.05], but was the group in which more oocytes were recovered [Group I: 9.43 ± 4.99 vs. Group II: 8.96 ± 4.82 vs. Group III: 8.78 ± 3.72 vs. Group IV: 11.62 ± 5.80; P < 0.05]. No significant differences were seen between the groups in terms of clinical and ongoing pregnancy, but among patients in whom two embryos with similar quality parameters (ASEBIR were transferred, the group treated with hp-hMG alone achieved a significantly greater clinical pregnancy rate as compared to all other groups [Group I: 31.6%, Group II: 56.4%, Group III: 28.7%, Group IV: 32.7%; P < 0.05]. Conclusions Although randomized clinical trials should be conducted to achieve a more reliable conclusion, these observations support the concept that stimulation with hp-hMG could be beneficial in normal responders women undergoing pituitary suppression with GnRH antagonists.

  8. Assessment of skeletal muscle fatigue of road maintenance workers based on heart rate monitoring and myotonometry

    Directory of Open Access Journals (Sweden)

    Kalkis Henrijs

    2006-07-01

    Full Text Available Abstract Objective This research work is dedicated to occupational health problems caused by ergonomic risks. The research object was road building industry, where workers have to work very intensively, have long work hours, are working in forced/constrained work postures and overstrain during the work specific parts of their bodies. The aim of this study was to evaluate the work heaviness degree and to estimate the muscle fatigue of workers after one week work cycle. The study group consisted of 10 road construction and maintenance workers and 10 pavers aged between 20 and 60 years. Methods Physical load were analyzed by measuring heart rate (HR, work postures (OWAS and perceived exertion (RPE. Assessments of the muscles strain and functional state (tone were carried out using myotonometric (MYO measurements. The reliability of the statistical processing of heart rate monitoring and myotonometry data was determined using correlating analysis. Results This study showed that that road construction and repairing works should be considered as a hard work according to average metabolic energy consumption 8.1 ± 1.5 kcal/min; paving, in its turn, was a moderately hard work according to 7.2 ± 1.1 kcal/min. Several muscle tone levels were identified allowing subdivision of workers into three conditional categories basing on muscle tone and fatigue: I – absolute muscle relaxation and ability to relax; II – a state of equilibrium, when muscles are able to adapt to the work load and are partly able to relax; and III – muscle fatigue and increased tone. It was also found out that the increase of muscle tone and fatigue mainly depend on workers physical preparedness and length of service, and less – on their age. Conclusion We have concluded that a complex ergonomic analysis consisting of heart rate monitoring, assessment of compulsive working postures and myotonometry is appropriate to assess the work heaviness degree and can provide prognosis of

  9. How and when will self-assessment improve maintenance of CANDU plants - evaluator's view

    Energy Technology Data Exchange (ETDEWEB)

    Mika, K. [Ontario Hydro. Bruce Nuclear Station. Tiverton, ON (Canada)

    1997-07-01

    Learning organizations use self-evaluation programs to compare their actual performance with their management's expectations and industry standards. In general, self-evaluations identify areas needing improvement. Self-evaluation activities in maintenance departments include self-assessments, management monitoring observations, root cause analyses, event investigations, benchmarking, use of operating experience, self-checking, and problem reporting systems. In Ontario Hydro Nuclear (OHN) we have used almost all forms of self-evaluation with mixed success. However, we did not use self-assessments. With emphasis on excellent maintenance this powerful form of self-evaluation is being introduced to all our plants. Because of its recency and relative inexperience with it, this paper is focused on self-assessment. The paper provides the author's perspective on how a self-assessment program would be evaluated by an independent internal evaluation and what attributes should be in place in order for maintenance departments to succeed in the implementation and successful continuation of the program. (author)

  10. Wind Turbine Blade Life-Time Assessment Model for Preventive Planning of Operation and Maintenance

    Directory of Open Access Journals (Sweden)

    Mihai Florian

    2015-09-01

    Full Text Available Out of the total wind turbine failure events, blade damage accounts for a substantial part, with some studies estimating it at around 23%. Current operation and maintenance (O&M practices typically make use of corrective type maintenance as the basic approach, implying high costs for repair and replacement activities as well as large revenue losses, mainly in the case of offshore wind farms. The recent development and evolution of condition monitoring techniques, as well as the fact that an increasing number of installed turbines are equipped with online monitoring systems, offers a large amount of information on the blades structural health to the decision maker. Further, inspections of the blades are often performed in connection with service. In light of the obtained information, a preventive type of maintenance becomes feasible, with the potential of predicting the blades remaining life to support O&M decisions for avoiding major failure events. The present paper presents a fracture mechanics based model for estimating the remaining life of a wind turbine blade, focusing on the crack propagation in the blades adhesive joints. A generic crack propagation model is built in Matlab based on a Paris law approach. The model is used within a risk-based maintenance decision framework to optimize maintenance planning for the blades lifetime.

  11. Assessment of reliability and maintenance of motor operated valves at Finnish NPPS

    International Nuclear Information System (INIS)

    Laakso, K.; Haenninen, S.; Simola, K.

    1994-01-01

    This paper summarizes two studies on motor operated valve (MOV) failure and maintenance experiences in Finnish nuclear power plants. In the first study, described in section 2 of this paper, the failure reports of MOVs at Finnish BWR units from a nine years' time period were analyzed in a systematic way. The dominant failure mechanisms were identified and time-dependencies in failure occurrence were studied. This study initiated an experience based reliability centered maintenance (RCM) analysis of motor operated valve drives, which is summarized in chapter 3 of this paper. The RCM analysis resulted in the identification and proposal of the most suitable and effective maintenance tasks for consideration. 9 refs, 3 figs, 1 tab

  12. Wind turbine blade life-time assessment model for preventive planning of operation and maintenance

    DEFF Research Database (Denmark)

    Florian, Mihai; Sørensen, John Dalsgaard

    2014-01-01

    Out of the total wind turbine failure events, blade damage accounts for a substantial part, with some studies estimating it at around 23%. Current operation and maintenance (O&M) practices typically make use of corrective type maintenance as the basic approach, implying high costs for repair...... of information on the blades structural health to the decision maker. Further, inspections of the blades are often performed in connection with service. In light of the obtained information, a preventive type of maintenance becomes feasible, with the potential of predicting the blades remaining life to support O......&M decisions for avoiding major failure events. The present paper presents a fracture mechanics based model for estimating the remaining life of a wind turbine blade, focusing on the crack propagation in the blades adhesive joints. A generic crack propagation model is built in Matlab based on a Paris law...

  13. Wind Turbine Blade Life-Time Assessment Model for Preventive Planning of Operation and Maintenance

    DEFF Research Database (Denmark)

    Florian, Mihai; Sørensen, John Dalsgaard

    2015-01-01

    Out of the total wind turbine failure events, blade damage accounts for a substantial part, with some studies estimating it at around 23%. Current operation and maintenance (O&M) practices typically make use of corrective type maintenance as the basic approach, implying high costs for repair...... of information on the blades structural health to the decision maker. Further, inspections of the blades are often performed in connection with service. In light of the obtained information, a preventive type of maintenance becomes feasible, with the potential of predicting the blades remaining life to support O......&M decisions for avoiding major failure events. The present paper presents a fracture mechanics based model for estimating the remaining life of a wind turbine blade, focusing on the crack propagation in the blades adhesive joints. A generic crack propagation model is built in Matlab based on a Paris law...

  14. Nuclear reactor maintenance technology assessment. Final summary report, September 16, 1978-September 15, 1979

    International Nuclear Information System (INIS)

    Tesar, D.; Ohanian, M.J.; Dugan, E.T.

    1980-01-01

    Nuclear power plants have exhibited a downtime of one day in four during the past decade. For mature LWR plants, 40% of this downtime is due to forced (unexpected) outages. These outages increase the loss of revenues and increase occupational radiation exposure. In 1979, the cost of maintenance of 70 operating plants was $1 billion per year. A fully remote maintenance technology would save 70% of this cost. PWR steam generator maintenance under fully remote system technology could save $270 million a year. BWR valve maintenance with fully remote technology could save $54,000,000 a year. Benefits for 150 plants by the early 1990's would be substantially higher; the total yearly savings would amount to $1.8 billion. The PWR steam generator would save $550 million while the BWR valve problem would save $140 million. For nuclear power plant maintenance, the vendors initially took steps to redesign and improve the reliability of the reactor system. The second step was to develop special maintenance tooling. The development of a generalized robotic manipulator having greater precision, dexterity, reliability, obstacle avoidance capability and load capacity is now feasible using microelectronics and computers. In order to drive this more general slave, the master controller must also be generalized to create a man-machine interface as transparent as possible; software modules must be developed which filter jitter, change scales, automaticaly control vision systems, and adapt force feedback signals in order to enhance the speed and precision of operation of the total system. A full complement of component technologies such as sensors, actuators, end-effectors, and remote TV vision systems must also be developed. Several other energy systems represent operations where such remote systems technology may be valuable

  15. Preventative maintenance cycle of contact switches for nuclear power plants based on lifetime assessment and economic analysis

    International Nuclear Information System (INIS)

    Shi Jie

    2010-01-01

    An approach to determine the preventive maintenance cycle was proposed in consideration of the lifetime, optimal cost and economy. Two parameters Weibull distribution was used to calculate the lifetime of contact switch. The block replacement model and age replacement model were built with the objective of optimal cost, and the preventive replacement cycle was accounted. Eight proposals for preventive replacement cycle were given. Economy model was applied to assess those proposals and the optimal proposal was confirmed. (authors)

  16. The Octyl Ester of Ginsenoside Rh2 Induces Lysosomal Membrane Permeabilization via Bax Translocation

    Directory of Open Access Journals (Sweden)

    Fang Chen

    2016-04-01

    Full Text Available Ginsenoside Rh2 is a potential pharmacologically active metabolite of ginseng. Previously, we have reported that an octyl ester derivative of ginsenoside Rh2 (Rh2-O, has been confirmed to possess higher bioavailability and anticancer effect than Rh2 in vitro. In order to better assess the possibility that Rh2-O could be used as an anticancer compound, the underlying mechanism was investigated in this study. The present results revealed that lysosomal destabilization was involved in the early stage of cell apoptosis in HepG2 cells induced by Rh2-O. Rh2-O could induce an early lysosomal membrane permeabilization with the release of lysosomal protease cathepsins to the cytosol in HepG2 cells. The Cat B inhibitor (leu and Cat D inhibitor (pepA inhibited Rh2-O-induced HepG2 apoptosis as well as tBid production and Δφm depolarization, indicating that lysosomal permeabilization occurred upstream of mitochondrial dysfunction. In addition, Rh2-O induced a significant increase in the protein levels of DRAM1 and Bax (p < 0.05 in lysosomes of HepG2 cells. Knockdown of Bax partially inhibited Rh2-O-induced Cat D release from lysosomes. Thus it was concluded that Rh2-O induced apoptosis of HepG2 cells through activation of the lysosomal-mitochondrial apoptotic pathway involving the translocation of Bax to the lysosome.

  17. Competencies Development and Self-Assessment in Maintenance Management E-Training

    Science.gov (United States)

    Papathanassiou, Nikos; Pistofidis, Petros; Emmanouilidis, Christos

    2013-01-01

    The maintenance management function requires staff to possess a truly multidisciplinary set of skills. This includes competencies from engineering and information technology to health and safety, management and finance, while also taking into account the normative and legislative issues. This body of knowledge is rarely readily available within a…

  18. Criteria and model for assessing and improving information technology maturity within maintenance

    International Nuclear Information System (INIS)

    Kans, M; Ehsanifard, K; Moniri, A

    2012-01-01

    Maintenance optimization and decision-making processes have been both influenced considerably by Information Technology (IT) developments mainly by increasing data availability. The decision-making process in its turn has affected systems trustworthiness positively. Therefore, theoretically speaking it could be said that Maintenance Management Information technology (MMIT) has the potential to provide applicable solutions for many of the maintenance management problems. Nevertheless, this potential has been hardly experienced in practice because of the mismatch between the level of IT maturity in the organizations and their selected MMIT solutions. To fill this gap this paper suggests a number of criteria which are crucial in decision making for selecting a MMIT application. The criteria are formed based on previous findings utilising an extensive literature review. A model is further developed for this purpose which is also tested on a case company active in power generation in Sweden. The model proved to be helpful when taking further improvement steps for reaching high utilization of IT in maintenance.

  19. Use of Influence Diagrams and Fuzzy Theory to Develop Assessment Method of Organizational Influences on Component Maintenance

    International Nuclear Information System (INIS)

    Yoonik Kim; Kwang-Won Ahn; Chang-Hyun Chung; Kil Yoo Kim; Joon-Eon Yang

    2002-01-01

    Organization can make influences on all the systems. Especially in case of nuclear power plants in which safety is established to be one of the most important operating goals, there have been a lot of research efforts for the hardware advancement. However in recent years, it has been widely recognized that organizational factors in nuclear power plants have an important influence on the safety attitudes and the safe behavior of individuals. Until now, any means to include assessments of organizational structure in probabilistic risk assessments have not been universally accepted. The objective of this work is to develop a method to assess organizational influences on component maintenance. Influence diagrams are introduced in this method as a decision making tool and fuzzy theory is used to reflect the vagueness in considering relevance of human activities in maintenance tasks. Introducing fuzzy theory to assess the organizational factors is deemed to a somewhat new trial, which makes it possible to convert linguistic vague descriptions into mathematical ones. Fuzzy linguistic descriptions offer an alternative and often complementary language to conventional, i.e., analytic approaches to modeling systems. Among the existing methodologies to assess organizational factors, the concept of the ω-factor model is utilized and the mechanism that organizational factors have influences on component maintenance is evaluated through composing influence diagrams. These influences go to failure rates and eventually affect component unavailability. Further study will make it possible that the influences of organizational factors on human error probabilities are incorporated into human reliability analysis and furthermore probabilistic safety assessment. (authors)

  20. How chemical pollution becomes a social problem. Risk communication and assessment through regional newspapers during the management of PCB pollutions of the Rhône River (France).

    Science.gov (United States)

    Comby, Emeline; Le Lay, Yves-François; Piégay, Hervé

    2014-06-01

    The case study of the polychlorinated biphenyl (PCB) pollutions of the Rhône River (France) offers the possibility of studying criteria for the construction of social problems that result from chemical pollution (2005-2010). We investigated the dynamics of competition that create and define pollution as a social problem and entail its decline. News outlets are crucial for determining how an environmental issue emerges locally or nationally; this study used newspapers to highlight the potential of new outlets as a data source to analyze discourse variability, science-policy-media connections and the hydrosphere. Media coverage was based on a content analysis and textual data analysis of 75 articles. Analytical frameworks such as the Downs Model and the Public Arena Model (Hilgartner and Bosk, 1988) that consider time and stakeholders were tested to determine how human alteration of the hydrosphere can become a social problem and to analyze different communication strategies held by stakeholders. In terms of management, we described the temporal dynamics of the social problem based on the case study and considered an explanation of the selections. We considered the organization of particular stakeholders who define the social problem from its beginning to end by focusing on their discourses, relationships, decision-making and political choices, and scientific studies. Despite some biases, newspapers are useful for retrospectively evaluating the emergence of a social problem in the public arena by describing it through discourse and then understanding the temporal patterns of information. Despite uncertainties and information flow, decisions are made and science is translated to the public. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Track 6: safety and risk management. Plant operational risk management. Plant Configuration Risk Assessment Methodology Development for Periodic Maintenance

    International Nuclear Information System (INIS)

    Yang, Huichang; Chung, Chang Hyun; Sung, Key Yong

    2001-01-01

    As the operation experiences of nuclear power plants (NPPs) in Korea accumulate and NPP safety functions become enhanced, the role of stable and optimal NPP operation within acceptable safety criteria becomes important at present. To accomplish the goal of safe and optimal operation, maintenance and its related activities should be regarded as the issues of most concern. Studies of methodologies for maintenance improvement and optimization have focused on system performance rather than on the hardware itself. From this point of view, the probabilistic methods are most useful. In terms of risk including core damage frequency and unavailability, the cause that might impact plant safety during normal maintenance activities can be identified and evaluated effectively. The results from these probabilistic analyses can provide insightful information for the reallocation of risk-contributing maintenance activity. This information can be utilized in a way that separates the significant risk-contributing maintenance activities from each other unless they are timely related. In Korea, the risk-monitoring program for operating NPPs is under development and will be implemented in 2003. To accomplish the risk-monitoring program objectives, suitable risk evaluation methods should be developed before the implementation of the risk-monitoring program. The plant configuration assessment methodology was developed for these reasons, and this method is to incorporate the field experiences into the risk calculation exactly within the limit of probabilistic methods. During normal plant operation, the plant operational risk changes frequently depending on the status of the plant system and the arrangement of the components. Specific plant systems or components are typically removed from service because of random equipment failure, planned preventive/predictive maintenance, corrective maintenance, surveillance testing, and operational bypass activities, and such events usually impact the

  2. Liposome-based delivery systems for ginsenoside Rh2: in vitro and in vivo comparisons

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Linqiang [China Pharmaceutical University, Department of Pharmaceutics, State Key Laboratory of Natural Medicines (China); Yu, Hua [University of Macao, Institute of Chinese Medical Sciences (China); Yin, Shaoping; Zhang, Ruixia; Zhou, Yudan; Li, Juan, E-mail: lijuancpu@163.com [China Pharmaceutical University, Department of Pharmaceutics, State Key Laboratory of Natural Medicines (China)

    2015-10-15

    The Ginsenoside Rh2 (Rh2) has been shown to possess anti-cancer properties both in vitro and in vivo. However, the poor bioavailability and fast plasma elimination limit the further clinical applications of Rh2 for cancer treatments. In the present study, three types of Rh2-loaded liposomes including Rh2-loaded normal liposome (Rh2-LP), Rh2-loaded cationic liposome (Rh2-CLP), and Rh2-loaded Methoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) liposome (Rh2-PLP) have been optimized and prepared with mean particle size of 80–125 nm. Compared to Rh2-LP, surface modifications with mPEG or octadecylamine significantly improve the physicochemical and biological properties both in vitro and in vivo. Moreover, PLP presented better tumor accumulation of the fluorescent cyanine dye, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR) in HepG2-xenografted nude mice than CLP (1.3-fold) or LP (1.6-fold) and prolong the resident time of DiR in tumor and organs (more than 24 h). The in vivo anti-cancer efficacy assessments indicate that Rh2-PLP presents the most activity on suppressing tumor growth in HepG2-xenografted mice than Rh2-LP and Rh2-CLP and without any significant toxicity. Our results indicate that mPEG-PLA modified liposome should be a potential and promising strategy to enhance the therapeutic index for anti-cancer agents.

  3. The use of probabilistic safety assessment (PSA) based maintenance indicators to increase the availability of safety related systems in nuclear power plants

    International Nuclear Information System (INIS)

    Kirchsteiger, C.

    1991-04-01

    This work describes the theoretical development of a Probabilistic Safety Assessment (PSA) based Performance Indicator (PI) model for a comprehensive Maintenance Efficiency Analysis (MEA) and its practical application to past operational history data of a certain nuclear power plant. Plant specific equipment history and maintenance work on data have been collected and analysed using various advanced statistical procedures (nonparametric methods, multivariate analysis in order to be able to estimate safety system related equipment and maintenance process trends. The main results of such a MEA case study are the trends in the (in)effectiveness of the performance of a selected safety system and its dominant components as well as the detection of the dominant maintenance related causes of its bad (good) equipment performance. Finally, the therefrom gained results are used to propose a new set of safety system-based and maintenance-related performance indicators, including suggestions for a corresponding plant specific maintenance data collection system. (author)

  4. The use of probabilistic safety assessment based maintenance indicators to increase the availability of safety related systems in nuclear power plants

    International Nuclear Information System (INIS)

    Kirchsteiger, C.

    1991-04-01

    This work describes the theoretical development of a Probabilistic Safety Assessment (PSA) based Performance Indicator (PI) model for a comprehensive Maintenance Efficiency Analysis (MEA) and its practical application to past operational history data of a certain Nuclear Power Plant. Plant specific equipment history and maintenance work order data have been collected and analysed using various advanced statistical procedures (nonparametric methods, multivariate analysis) in order to be able to estimate safety system related equipment and maintenance process trends. The main results of such a MEA case study are the trends in the (in)effectiveness of the performance of a selected safety system and its dominant maintenance related causes of its bad (good) equipment performance. Finally, the therefrom gained results are used to propose a new set of safety system based and maintenance related Performance Indicators, including suggestions for a corresponding plant specific maintenance data collection system. (author)

  5. Assessing organizational culture in complex sociotechnical systems. Methodological evidence from studies in nuclear power plant maintenance organizations

    International Nuclear Information System (INIS)

    Reiman, T.

    2007-03-01

    Failures in industrial organizations dealing with hazardous technologies can have widespread consequences for the safety of the workers and the general population. Psychology can have a major role in contributing to the safe and reliable operation of these technologies. Most current models of safety management in complex sociotechnical systems such as nuclear power plant maintenance are either non-contextual or based on an overly-rational image of an organization. Thus, they fail to grasp either the actual requirements of the work or the socially-constructed nature of the work in question. The general aim of the present study is to develop and test a methodology for contextual assessment of organizational culture in complex sociotechnical systems. This is done by demonstrating the findings that the application of the emerging methodology produces in the domain of maintenance of a nuclear power plant (NPP). The concepts of organizational culture and organizational core task (OCT) are operationalized and tested in the case studies

  6. Assessing organizational culture in complex sociotechnical systems. Methodological evidence from studies in nuclear power plant maintenance organizations

    Energy Technology Data Exchange (ETDEWEB)

    Reiman, T.

    2007-03-15

    Failures in industrial organizations dealing with hazardous technologies can have widespread consequences for the safety of the workers and the general population. Psychology can have a major role in contributing to the safe and reliable operation of these technologies. Most current models of safety management in complex sociotechnical systems such as nuclear power plant maintenance are either non-contextual or based on an overly-rational image of an organization. Thus, they fail to grasp either the actual requirements of the work or the socially-constructed nature of the work in question. The general aim of the present study is to develop and test a methodology for contextual assessment of organizational culture in complex sociotechnical systems. This is done by demonstrating the findings that the application of the emerging methodology produces in the domain of maintenance of a nuclear power plant (NPP). The concepts of organizational culture and organizational core task (OCT) are operationalized and tested in the case studies

  7. The use of probabilistic risk assessment to satisfy the Nuclear Regulatory Commission's maintenance rule

    International Nuclear Information System (INIS)

    Dubord, R.M.

    1993-05-01

    Maintenance and inspection at nuclear power plants consumes a large portion of a utility's resources, making resource allocation for such procedures vital. The NRC Maintenance Rule, due to be implemented in July of 1996, requires utilities to select systems, structures, and components (SSCS) important to safety and to develop a monitoring program to ensure that these SSCs are capable of fulfilling their intended functions. In light of these concerns, two ratios were developed to compare the risk significance of individual components with the amount of plant staff time, or burden, associated with inspecting the component. These risk/burden ratios point out existing disparities between current inspection practices and safety concerns. These ratios can be used to develop new inspection schedules constituting a more equitable risk to burden distribution

  8. Interactive virtual mock-ups for Remote Handling compatibility assessment of heavy components

    Energy Technology Data Exchange (ETDEWEB)

    Oosterhout, J. van, E-mail: j.vanoosterhout@differ.nl [FOM Institute DIFFER (Dutch Institute for Fundamental Energy Research), Association EURATOM-FOM, Partner in the Trilateral Euregio Cluster, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Heemskerk, C.J.M.; Koning, J.F. [Heemskerk Innovative Technology B.V., Jonckerweg 12, 2201 DZ Noordwijk 6 (Netherlands); Ronden, D.M.S.; Baar, M. de [FOM Institute DIFFER (Dutch Institute for Fundamental Energy Research), Association EURATOM-FOM, Partner in the Trilateral Euregio Cluster, PO Box 1207, 3430 BE Nieuwegein (Netherlands)

    2014-10-15

    Highlights: •Specific ITER components require RHCA on hardware mock-ups. •Hardware mock-ups are expensive and have a long lead time. •Interactive Virtual Reality mock-ups are readily available and easily adapted. •This paper analysis and proposes improvements to simulator capabilities. -- Abstract: ITER standards Tesini (2009) require hardware mock-ups to validate the Remote Handling (RH) compatibility of RH class 1- and critical class 2-components. Full-scale mock-ups of large ITER components are expensive, have a long lead time and lose their relevance in case of design changes. Interactive Virtual Reality simulations with real time rigid body dynamics and contact interaction allow for RH Compatibility Assessment during the design iterations. This paper explores the use of interactive virtual mock-ups to analyze the RH compatibility of heavy component handling and maintenance. It infers generic maintenance operations from the analysis and proposes improvements to the simulator capabilities.

  9. Interactive virtual mock-ups for Remote Handling compatibility assessment of heavy components

    International Nuclear Information System (INIS)

    Oosterhout, J. van; Heemskerk, C.J.M.; Koning, J.F.; Ronden, D.M.S.; Baar, M. de

    2014-01-01

    Highlights: •Specific ITER components require RHCA on hardware mock-ups. •Hardware mock-ups are expensive and have a long lead time. •Interactive Virtual Reality mock-ups are readily available and easily adapted. •This paper analysis and proposes improvements to simulator capabilities. -- Abstract: ITER standards Tesini (2009) require hardware mock-ups to validate the Remote Handling (RH) compatibility of RH class 1- and critical class 2-components. Full-scale mock-ups of large ITER components are expensive, have a long lead time and lose their relevance in case of design changes. Interactive Virtual Reality simulations with real time rigid body dynamics and contact interaction allow for RH Compatibility Assessment during the design iterations. This paper explores the use of interactive virtual mock-ups to analyze the RH compatibility of heavy component handling and maintenance. It infers generic maintenance operations from the analysis and proposes improvements to the simulator capabilities

  10. Assessment of family functioning in families of patients on methadone maintenance treatment

    Directory of Open Access Journals (Sweden)

    Marković Jasminka

    2015-01-01

    Full Text Available Addiction has multi-factorial etiopathogenesis. Morbidity risk factors include both individual and social factors. Social factors are considered to be very important, especially at the initial stage of taking the substance. Family and the social environment, with their behavior and social norms, are the primary psychosocial determinants. Family functioning has an impact on both the development and the maintenance of addictions, so it is an important research topic. The aim of this study was to determine if families of drug addicts who are on methadone maintenance treatment differ in the level of functionality from families without addiction problems. The study sample included 100 persons divided into two groups - clinical and control. The clinical group consisted of 50 persons - drug addicts who are on methadone maintenance treatment, whereas the control group consisted of 50 persons without addiction problems. FACES IV and General questionnaire were used as instruments for the control group, and POMPIDU questionnaire for the clinical group. The results show that the families of addicts who are in methadone substitution treatment program vary in the level of functionality compared to families in which there is no problem of addiction and in a way that the families of the control group are more functional. These results in our region confirmed earlier results on the connection between family dysfunction and substance abuse, which may have significant implications in the treatment and prevention programs of addictions.

  11. The kidneys play a central role in the clearance of rhGH in rats

    DEFF Research Database (Denmark)

    Vestergaard, Bill; Thygesen, Peter; Kreilgaard, Mads

    2016-01-01

    at treatment of patients with growth hormone disorders. The purpose of this study was to investigate the relative importance of the kidneys in the clearance of rhGH. The study employed a newly validated nephrectomy rat model and a population based pharmacokinetic approach to assess renal clearance of rh...... that renal clearance plays a pivotal role in the elimination of rhGH in rats....

  12. Videoscopic assessment of the maintenance status of gamma radiography exposure containers employed in Brazil

    International Nuclear Information System (INIS)

    Candeias, J P; Estrada, J J S; Pinho, A S; D'Avila, R L; Ramalho, A T

    2007-01-01

    Industrial radiography is the most frequent method of non-destructive testing (NDT) used by Brazilian industrial facilities for investigating the material integrity of a test object. In Brazil, industrial radiography employs around 220 x-ray and 290 gamma radiography machines. About 90% of the latter uses iridium ( 192 Ir) sources. The large majority of 192 Ir projectors in operation in Brazil have been in continuous usage for more than 25 years, which means that they are old and worn-out. Usually the majority of accidents concerning gamma radiography occur during the return of the source into the exposure container. Poor maintenance or imperfections of the internal channel of the exposure container can lead to accidental source exposure. In the present work the internal tube of 65 gamma machines from nine Brazilian companies that render gamma radiography services were analysed using an industrial videoscope. The internal images from the projectors were compared with the internal image of an apparatus that had never been used, i.e. has never received a radioactive source. From the 65 machines evaluated, nine showed irregularities of the internal tube. It was also observed that each company follows a different methodology for the maintenance and lubrication of the exposure containers and drive cables

  13. Videoscopic assessment of the maintenance status of gamma radiography exposure containers employed in Brazil.

    Science.gov (United States)

    Candeias, J P; Estrada, J J S; Pinho, A S; D'Avila, R L; Ramalho, A T

    2007-03-01

    Industrial radiography is the most frequent method of non-destructive testing (NDT) used by Brazilian industrial facilities for investigating the material integrity of a test object. In Brazil, industrial radiography employs around 220 x-ray and 290 gamma radiography machines. About 90% of the latter uses iridium ((192)Ir) sources. The large majority of (192)Ir projectors in operation in Brazil have been in continuous usage for more than 25 years, which means that they are old and worn-out. Usually the majority of accidents concerning gamma radiography occur during the return of the source into the exposure container. Poor maintenance or imperfections of the internal channel of the exposure container can lead to accidental source exposure. In the present work the internal tube of 65 gamma machines from nine Brazilian companies that render gamma radiography services were analysed using an industrial videoscope. The internal images from the projectors were compared with the internal image of an apparatus that had never been used, i.e. has never received a radioactive source. From the 65 machines evaluated, nine showed irregularities of the internal tube. It was also observed that each company follows a different methodology for the maintenance and lubrication of the exposure containers and drive cables.

  14. Videoscopic assessment of the maintenance status of gamma radiography exposure containers employed in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Candeias, J P [IME, Military Institute of Engineering, Praca Gal Tiburcio 80, Praia Vermelha, Rio de Janeiro, 22290-270 (Brazil); Estrada, J J S [IME, Military Institute of Engineering, Praca Gal Tiburcio 80, Praia Vermelha, Rio de Janeiro, 22290-270 (Brazil); Pinho, A S [Institute of Radioprotection and Dosimetry (IRD/CNEN), Avenida Salvador Allende, PO Box 37750, Rio de Janeiro, 22780-160 (Brazil); D' Avila, R L [Institute of Radioprotection and Dosimetry (IRD/CNEN), Avenida Salvador Allende, PO Box 37750, Rio de Janeiro, 22780-160 (Brazil); Ramalho, A T [Institute of Radioprotection and Dosimetry (IRD/CNEN), Avenida Salvador Allende, PO Box 37750, Rio de Janeiro, 22780-160 (Brazil)

    2007-03-01

    Industrial radiography is the most frequent method of non-destructive testing (NDT) used by Brazilian industrial facilities for investigating the material integrity of a test object. In Brazil, industrial radiography employs around 220 x-ray and 290 gamma radiography machines. About 90% of the latter uses iridium ({sup 192}Ir) sources. The large majority of {sup 192}Ir projectors in operation in Brazil have been in continuous usage for more than 25 years, which means that they are old and worn-out. Usually the majority of accidents concerning gamma radiography occur during the return of the source into the exposure container. Poor maintenance or imperfections of the internal channel of the exposure container can lead to accidental source exposure. In the present work the internal tube of 65 gamma machines from nine Brazilian companies that render gamma radiography services were analysed using an industrial videoscope. The internal images from the projectors were compared with the internal image of an apparatus that had never been used, i.e. has never received a radioactive source. From the 65 machines evaluated, nine showed irregularities of the internal tube. It was also observed that each company follows a different methodology for the maintenance and lubrication of the exposure containers and drive cables.

  15. Reliability Assessment and Reliability-Based Inspection and Maintenance of Offshore Wind Turbines

    DEFF Research Database (Denmark)

    Ramirez, José Rangel

    actions are the most relevant and effective means of control of deterioration. The risk-based inspection planning methodology, based on Bayesian decision theory, represents an important tool to identify the suitable strategy to inspect and control the deterioration in structures such as offshore wind...... performance during the life cycle. The deterioration processes, such as fatigue and corrosion, are typically affecting offshore structural systems. This damage decreases the system performance and increases the risk of failure, thus not fulfilling the established safety criteria. Inspection and maintenance...... to their offshore location, no pollution risks and low human risks since they are unmanned. This allows the allocation of lower reliability level compared to e.g. oil & gas installations. With the incursion to water depths between 20 and 50 meters, the use of jacket and tripod structures represents a feasible...

  16. Normal maintenance costs drop at Duke Power: Impact of Hurricane Hugo being assessed

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    William S. Lee, chairman and president of Duke Power Company, said that a third-quarter earnings increase was primarily due to lower plant maintenance costs, but that figures aren't in yet on the damages related to Hurricane Hugo, which ripped through the Carolinas in late September. The severity of this storm is unprecedented in the company's history, he said. Lee also announced that Duke Power has entered into a new partnership with the Fluor Corporation, of Irvine, California. The two companies, operating under the name Duke/Fluor Daniel, will offer the power industry a single source of design, engineering, construction, and operation services for new and existing coal-fired plants

  17. A RhABF2/Ferritin module affects rose (Rosa hybrida) petal dehydration tolerance and senescence by modulating iron levels.

    Science.gov (United States)

    Liu, Jitao; Fan, Youwei; Zou, Jing; Fang, Yiqun; Wang, Linghao; Wang, Meng; Jiang, Xinqiang; Liu, Yiqing; Gao, Junping; Zhang, Changqing

    2017-12-01

    Plants often develop the capacity to tolerate moderate and reversible environmental stresses, such as drought, and to re-establish normal development once the stress has been removed. An example of this phenomenon is provided by cut rose (Rosa hybrida) flowers, which experience typical reversible dehydration stresses during post-harvest handling after harvesting at the bud stages. The molecular mechanisms involved in rose flower dehydration tolerance are not known, however. Here, we characterized a dehydration- and abscisic acid (ABA)-induced ferritin gene (RhFer1). Dehydration-induced free ferrous iron (Fe 2+ ) is preferentially sequestered by RhFer1 and not transported outside of the petal cells, to restrict oxidative stresses during dehydration. Free Fe 2+ accumulation resulted in more serious oxidative stresses and the induction of genes encoding antioxidant enzyme in RhFer1-silenced petals, and poorer dehydration tolerance was observed compared with tobacco rattle virus (TRV) controls. We also determined that RhABF2, an AREB/ABF transcription factor involved in the ABA signaling pathway, can activate RhFer1 expression by directly binding to its promoter. The silencing of RhABF2 decreased dehydration tolerance and disrupted Fe homeostasis in rose petals during dehydration, as did the silencing of RhFer1. Although both RhFer1 and Fe transporter genes are induced during flower natural senescence in plants, the silencing of RhABF2 or RhFer1 accelerates the petal senescence processes. These results suggest that the regulatory module RhABF2/RhFer1 contributes to the maintenance of Fe levels and enhances dehydration tolerance through the action of RhFer1 locally sequestering free Fe 2+ under dehydration conditions, and plays synergistic roles with transporter genes during flower senescence. © 2017 The Authors The Plant Journal © 2017 John Wiley & Sons Ltd.

  18. Premium cost optimization of operational and maintenance of green building in Indonesia using life cycle assessment method

    Science.gov (United States)

    Latief, Yusuf; Berawi, Mohammed Ali; Basten, Van; Budiman, Rachmat; Riswanto

    2017-06-01

    Building has a big impact on the environmental developments. There are three general motives in building, namely the economy, society, and environment. Total completed building construction in Indonesia increased by 116% during 2009 to 2011. It made the energy consumption increased by 11% within the last three years. In fact, 70% of energy consumption is used for electricity needs on commercial buildings which leads to an increase of greenhouse gas emissions by 25%. Green Building cycle costs is known as highly building upfront cost in Indonesia. The purpose of optimization in this research improves building performance with some of green concept alternatives. Research methodology is mixed method of qualitative and quantitative approaches through questionnaire surveys and case study. Assessing the successful of optimization functions in the existing green building is based on the operational and maintenance phase with the Life Cycle Assessment Method. Choosing optimization results were based on the largest efficiency of building life cycle and the most effective cost to refund.

  19. Industry assessment of human factors in aviation maintenance and inspection research program : an assessment of industry awareness and use of the Federal Aviation Administration Office of Aviation Medicine Human Factors in Aviation Maintenance and Inspect

    Science.gov (United States)

    1998-03-01

    Ten years ago the Federal Aviation Administration (FAA) Office of Aviation Medicine embarked on a research and development program dedicated to human factors in aviation maintenance and inspection. Since 1989 FAA has invested over $12M in maintenance...

  20. Magnetic properties of Co-Rh and Ni-Rh nanowires

    International Nuclear Information System (INIS)

    Sondon, Tristana; Saul, Andres; Guevara, Javier

    2007-01-01

    We have calculated the magnetic properties of pure Ni, Co and Rh, and alloyed Co-Rh and Ni-Rh free-standing nanowires by an ab initio method. We have found that the pure Co and Ni wires present an enhanced magnetic moment with respect to their bulk values, and we have obtained that a magnetic order appears for pure Rh wires. For concentrations up to 50% Rh, in the alloyed Ni-Rh linear chains there is an enhancement of the total magnetic moment with respect to the pure nanowires, and in the case of Co-Rh the alloying with Rh enhances the Co magnetic moment. In both systems we obtain very high Rh magnetic moments

  1. Cell saver filtering of extravasated rhBMP-2 after degenerative scoliosis reconstruction

    Directory of Open Access Journals (Sweden)

    Gabriel Liu, MBBCh, MSc, FRCS, FAMS (Orth

    2015-06-01

    Full Text Available RhBMP-2 is a bone fusion enhancer commonly used in scoliosis reconstruction surgery. It is delivered via an absorbable collagen sponge but has been known to migrate away from its delivery site. RhBMP-2 extravasation in surgical drainage has been noted during first two days post-surgery. Cell savers are widely used in scoliosis reconstruction to limit transfusion requirements and are commonly deployed in cases where rhBMP-2 is used for fusion augmentation. It is not known whether rhBMP-2 is present in salvaged blood or filtered away during cell saver recycling. Through this case series of four patients who underwent scoliosis reconstruction, we assess cell saver efficacy in filtering rhBMP-2 molecules by quantifying the amount of rhBMP-2 present in salvaged blood obtained after postoperative drainage recycling by OrthoPAT® cell saver and comparing it to rhBMP-2 leakage in postoperative drainage without cell saver recycling. We report an almost 10-fold reduction of rhBMP-2 concentration in salvaged blood obtained after cell saver recycling of postoperative drainage, suggesting cell saver effectiveness in filtering rhBMP-2 molecules.

  2. Numerical modelling to assess maintenance strategy management options for a small tidal inlet

    Science.gov (United States)

    Shaeri, Saeed; Tomlinson, Rodger; Etemad-Shahidi, Amir; Strauss, Darrell

    2017-03-01

    Small tidal inlets are found to be more sensitive to anthropogenic alteration than their larger counterparts. Such alterations, although typically supported by technical design reports, sometimes require amendments or modification. One of the most suitable tools to conduct the necessary studies in this regard is numerical modelling, since the behaviour of the inlet system in response to proposed remedial actions, can easily be identified. In this paper, various alternative proposals are investigated to determine the most practical and viable option to mitigate the need for ongoing maintenance at a typical small, jettied tidal inlet. The main tool to investigate the alternatives is the hydro-sedimentological modelling of the inlet system, which was performed using the Delft3D software package. The proposed alternative entrance modifications were based upon structural alterations of the inlet system (such as a jetty extension or submerged weir) and non-structural scenarios (such as a change of the time of the dredging campaign or the deposition location of the dredged material). It was concluded that whilst a detailed study is inevitable in order to achieve a comprehensive design plan, based upon the results of this study the construction of a submerged weir at the entrance channel can satisfy the needs of most of the stakeholders, with justifiable costs over a longer period.

  3. Results of potential exposure assessments during the maintenance and cleanout of deposition equipment

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, E., E-mail: eric.zimmermann@cea.fr; Derrough, S.; Locatelli, D.; Durand, C.; Fromaget, J. L.; Lefranc, E.; Ravanel, X.; Garrione, J. [Nanosafety Platform, CEA, DRT (France)

    2012-10-15

    This study is a compilation of results obtained during the cleanout of deposition equipment such as chemical vapor deposition or physical vapor deposition The measurement campaigns aimed to evaluate the potential exposure to nanoaerosols in the occupational environment and were conducted in the workspace. The characterization of aerosols includes measurements of the concentration using condensation particle counters and measurements of the size distribution using fast mobility particle sizer, scanning mobility particle sizer, and electrical low pressure impactor (ELPI). Particles were sampled using collection membranes placed on the ELPIs stages. The samples were analyzed with an SEM-EDS to provide information including size, shape, agglomeration state, and the chemical composition of the particles. The majority of the time, no emission of nanoparticles (NPs) was measured during the use of the molecular deposition equipment or when opening the chambers, mainly due to the enclosed processes. On the other hand, the maintenance of the equipment, and especially the cleanout step, could induce high concentrations of NPs in the workplace following certain processes. Values of around 1 million particles/cm{sup 3} were detected with a size distribution including a high concentration of particles around 10 nm.

  4. Characterization of Rh films on Ta(110)

    International Nuclear Information System (INIS)

    Jiang, L.Q.; Ruckman, M.W.; Strongin, M.

    1989-01-01

    The surface and electronic structure of Rh films on Ta(110) up to several monolayers thick on Ta(110) are characterized by photoemission, Auger emission, low energy electron diffraction and low energy ion scattering. From the variation of the Rh Auger peak-to-peak intensity as a function of evaporation time, Rh/Ta(110) appears to grow in the Stranski-Krastanov mode at room temperature. However, the LEIS data show that the Rh adatoms begin to cluster on Ta(110) before growth of the monolayer is completed. Diffuse LEED scattering suggests that the Rh films are disordered. Photoemission shows that Rh chemisorption on Ta(110) generates two peaks located at 1.2 and 2. 5 eV binding energy during the initial phase of thin film growth (0 3.7 ML). Photoemission data for CO covered surfaces show that CO dissociates on the Rh/Ta(110) surface for Rh coverages less than 2.5 ML and also show that the Rh clusters develop at least one site capable of molecular CO adsorption above 0.3 ML Rh coverage. 38 refs., 5 figs

  5. Context-Dependent Prognostics and Health Assessment: A Condition-Based Maintenance Approach That Supports Mission Compliance

    Energy Technology Data Exchange (ETDEWEB)

    Allgood, G.O.; Kercel, S.W.

    1999-04-19

    In today's manufacturing environment, plants, systems, and equipment are being asked to perform at levels not thought possible a decade ago. The intent is to improve process operations and equipment reliability, availability, and maintainability without costly upgrades. Of course these gains must be achieved without impacting operational performance. Downsizing is also taking its toll on operations. Loss of personnel, particularly those who represent the corporate history, is depleting US industries of their valuable experiential base which has been relied on so heavily in the past. These realizations are causing companies to rethink their condition-based maintenance policies by moving away from reacting to equipment problems to taking a proactive approach by anticipating needs based on market and customer requirements. This paper describes a different approach to condition-based maintenance-context-dependent prognostics and health assessment. This diagnostic capability is developed around a context-dependent model that provides a capability to anticipate impending failures and determine machine performance over a protracted period of time. This prognostic capability links operational requirements to an economic performance model. In this context, a system may provide 100% operability with less than 100% functionality. This paradigm is used to facilitate optimal logistic supply and support.

  6. Maintenance Plan for the Hanford Immobilized Low-Activity Tank Waste Performance Assessment

    International Nuclear Information System (INIS)

    MANN, F.M.

    2000-01-01

    The plan for maintaining the Hanford Immobilized Low-Activity Tank Waste Performance Assessment (PA) is described. The plan includes expected work on PA reviews and revisions, waste reports, monitoring, other operational activities, etc

  7. [Frequencies of blood groups, ABO and Rh D incompatibility in post-delivery women and their liveborn].

    Science.gov (United States)

    Baiochi, Eduardo; Camano, Luiz; Sass, Nelson; Colas, Osmar Ribeiro

    2007-01-01

    This study aimed to assess the frequency of different blood phenotypes and to predict the risk of Rh D alloimmunization and maternal-fetal incompatibility in a Brazilian population living in the West zone of the city of São Paulo-Brazil. This descriptive study evaluated 2,372 post-delivery women and their liveborn during one year. Blood types were analyzed by means of tube agglutination tests. The blood type frequencies were: 50.67 O, 32.17 A, 13.45 B, 3.75 AB, 90.34 Rh D(+) and 9.66 Rh D(-). ABO maternal-fetal incompatibility was detected in 18.4% and Rh D incompatibility in 7%. The fraction of Rh D(-) population at high risk for Rh D alloimmunization was 82%, emphasizing the importance of Rh D alloimmunization profilaxis.

  8. Human biomonitoring after chemical incidents and during short-term maintenance work as a tool for exposure analysis and assessment.

    Science.gov (United States)

    Bader, M; Van Weyenbergh, T; Verwerft, E; Van Pul, J; Lang, S; Oberlinner, C

    2014-12-15

    Human biomonitoring (HBM) is frequently used for the analysis and assessment of exposure to chemicals under routine working conditions. In recent years, HBM has also been applied to monitor the exposure of the general population, and of emergency responders in the aftermath of chemical incidents. Two examples of targeted HBM programs in the chemical industry are described and discussed in this paper: (1) analysis and assessment of the exposure of firefighters and chemical workers after the spill of p-chloroaniline from a burning chemical barrel, and (2) biomonitoring of maintenance workers potentially exposed to benzene during regular turnarounds. The results of these investigations underline that human biomonitoring contributes substantially to comprehensive exposure analyses, human health risk assessments and communication. In addition, regular HBM surveillance and feedback can assist in the continuous improvement of workplace safety measures and exposure control. In conclusion, data on accidental or short-term exposure to hazardous chemicals are an important source of information for the further development of limit and assessment values, the validation of biomarkers and of targeted HBM programs for both routine monitoring and disaster management. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  9. Assessing cognitive processes related to insomnia: A review and measurement guide for Harvey's cognitive model for the maintenance of insomnia.

    Science.gov (United States)

    Hiller, Rachel M; Johnston, Anna; Dohnt, Hayley; Lovato, Nicole; Gradisar, Michael

    2015-10-01

    Cognitive processes play an important role in the maintenance, and treatment of sleep difficulties, including insomnia. In 2002, a comprehensive model was proposed by Harvey. Since its inception the model has received >300 citations, and provided researchers and clinicians with a framework for understanding and treating insomnia. The aim of this review is two-fold. First, we review the current literature investigating each factor proposed in Harvey's cognitive model of insomnia. Second, we summarise the psychometric properties of key measures used to assess the model's factors and mechanisms. From these aims, we demonstrate both strengths and limitations of the current knowledge of appropriate measurements associated with the model. This review aims to stimulate and guide future research in this area; and provide an understanding of the resources available to measure, target, and resolve cognitive factors that may maintain chronic insomnia. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Characterization of Rh films on Ta(110)

    International Nuclear Information System (INIS)

    Jiang, L.Q.; Ruckman, M.W.; Strongin, M.

    1990-01-01

    The surface and electronic structure of Rh films on Ta(110) up to several monolayers thick on Ta(110) are characterized by photoemission, Auger emission, low-energy electron diffraction (LEED) and low-energy ion scattering (LEIS). From the variation of the Rh Auger peak-to-peak intensity as a function of evaporation time, Rh appears to grow in the Stranski--Krastanov mode at room temperature. However, the LEIS data show that the Rh adatoms begin to cluster on Ta(110) before growth of the monolayer is completed. Diffuse LEED scattering suggests that the Rh films are disordered. Photoemission shows that Rh chemisorption on Ta(110) generates two peaks located at -1.5 and -2.5 eV binding energy during the initial phase of thin-film growth (0 3.7 ML). CO dissociates on the Rh/Ta(110) surface for Rh coverages<2.5 ML and the surface develops a site capable of molecular CO adsorption above 0.3-ML Rh coverage

  11. The ITER EC H and CD Upper Launcher: Maintenance concepts

    International Nuclear Information System (INIS)

    Ronden, D.M.S.; Baar, M. de; Chavan, R.; Elzendoorn, B.S.Q.; Grossetti, G.; Heemskerk, C.J.M.; Koning, J.F.; Landis, J.-D.; Spaeh, P.; Strauss, D.

    2013-01-01

    Highlights: ► We explain how an overall maintenance strategy defines individual maintenance tasks. ► Concepts are presented for replacement strategies of the in-vessel optical components. ► Vertical placement of the Upper Launcher in the Hot Cell may simplify maintenance. -- Abstract: Maintenance of the ITER EC H and CD Upper Launcher (UL) shall be performed through the use of Remote Handling (RH) in the ITER Hot Cell Facility (HCF). The UL design will have to be fully compliant with ITER RH maintenance requirements and the set of RH tooling and services available in the HCF. This paper describes the development of an overall maintenance strategy for the UL, starting from a listing of all conceivable maintenance operations, including hands-on tasks. Components for which design concepts are discussed in this paper are the Blanket Shield Module (BSM), the steering mirror (M4), the mid optics (M1, M2) and the waveguide (WG) feed-through plate. Aspects related to RH documentation, overall maintenance strategy and design concepts for optimizing the maintainability of the UL are presented

  12. Assessment of the Performance of Several Roadway Mixes under Rain, Snow, and Winter Maintenance Activities

    OpenAIRE

    Flintsch, Gerardo W.

    2004-01-01

    The purpose of this study was to assess the relative functional performance, including skid resistance and splash and spray, of five hot-mix-asphalt (HMA) surfaces and a tinned portland cement concrete highway surface during controlled wet and wintry weather events. The study compared the way that these surfaces respond to various deicing and anti-icing snow removal and ice control techniques under artificial wintry conditions. In addition, the splash and spray characteristics of the surfaces...

  13. Environmental Assessment for the General Plan and Maintenance of Patrick Air Force Base, Florida

    Science.gov (United States)

    2005-05-01

    considered viable. P A F B G e n e r a l P l a n E A 2 Environmental Effects The General Plan EA evaluated the environmental impacts of...year cycle. The potential environmental effects were assessed for the following environmental resource areas: air quality, water quality, geology...ADP Area Development Plan AF Air Force AFB Air Force Base AFETR Air Force Eastern Test Range AFI Air Force Instruction AFMAN Air Force Manual

  14. Maintenance methods

    International Nuclear Information System (INIS)

    Sanchis, H.; Aucher, P.

    1990-01-01

    The maintenance method applied at the Hague is summarized. The method was developed in order to solve problems relating to: the different specialist fields, the need for homogeneity in the maintenance work, the equipment diversity, the increase of the materials used at the Hague's new facilities. The aim of the method is to create a knowhow formalism, to facilitate maintenance, to ensure the running of the operations and to improve the estimation of the maintenance cost. One of the method's difficulties is the demonstration of the profitability of the maintenance operations [fr

  15. Rh Variability in Multi-Ethnic Perspective: Consequences for RH Genotyping

    NARCIS (Netherlands)

    G.H.M. Tax

    2006-01-01

    textabstractThe RhD bloodgroup was first described by Levine en Stetson in 1939 after the manifestation of a hemolytic transfusion reaction in a woman who recently gave birth, after transfusion with her husbands red cells. The RhD-negative woman produced antibodies against the RhD present on the

  16. Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

    DEFF Research Database (Denmark)

    Payne, Ruth O; Silk, Sarah E; Elias, Sean C

    2017-01-01

    serum antibodies exhibited cross-strain functional growth inhibition activity (GIA) in vitro, targeted linear and conformational epitopes within RH5, and inhibited key interactions within the RH5 invasion complex. This is the first time to our knowledge that substantial RH5-specific responses have been...

  17. GnRH-agonist versus GnRH-antagonist IVF cycles

    DEFF Research Database (Denmark)

    Papanikolaou, E G; Pados, G; Grimbizis, G

    2012-01-01

    In view of the current debate concerning possible differences in efficacy between the two GnRH analogues used in IVF stimulated cycles, the current study aimed to explore whether progesterone control in the late follicular phase differs when GnRH antagonist is used as compared with GnRH agonist...

  18. RH-TRU Waste Content Codes

    Energy Technology Data Exchange (ETDEWEB)

    Washington TRU Solutions

    2007-07-01

    The Remote-Handled Transuranic (RH-TRU) Content Codes (RH-TRUCON) document describes the inventory of RH-TRU waste within the transportation parameters specified by the Remote-Handled Transuranic Waste Authorized Methods for Payload Control (RH-TRAMPAC).1 The RH-TRAMPAC defines the allowable payload for the RH-TRU 72-B. This document is a catalog of RH-TRU 72-B authorized contents by site. A content code is defined by the following components: • A two-letter site abbreviation that designates the physical location of the generated/stored waste (e.g., ID for Idaho National Laboratory [INL]). The site-specific letter designations for each of the sites are provided in Table 1. • A three-digit code that designates the physical and chemical form of the waste (e.g., content code 317 denotes TRU Metal Waste). For RH-TRU waste to be transported in the RH-TRU 72-B, the first number of this three-digit code is “3.” The second and third numbers of the three-digit code describe the physical and chemical form of the waste. Table 2 provides a brief description of each generic code. Content codes are further defined as subcodes by an alpha trailer after the three-digit code to allow segregation of wastes that differ in one or more parameter(s). For example, the alpha trailers of the subcodes ID 322A and ID 322B may be used to differentiate between waste packaging configurations. As detailed in the RH-TRAMPAC, compliance with flammable gas limits may be demonstrated through the evaluation of compliance with either a decay heat limit or flammable gas generation rate (FGGR) limit per container specified in approved content codes. As applicable, if a container meets the watt*year criteria specified by the RH-TRAMPAC, the decay heat limits based on the dose-dependent G value may be used as specified in an approved content code. If a site implements the administrative controls outlined in the RH-TRAMPAC and Appendix 2.4 of the RH-TRU Payload Appendices, the decay heat or FGGR

  19. Assessing the Relationship between Airlines' Maintenance Outsourcing and Aviation Professionals' Job Satisfaction

    Science.gov (United States)

    McCamey, Rotorua

    The current economic and security challenges placed an additional burden on U.S. airlines to provide optimum service at reasonable costs to the flying public. In efforts to stay competitive, U.S. airlines increased foreign-based outsourcing of aircraft major repair and overhaul (MRO) mainly to reduce labor costs and conserve capital. This concentrated focus on outsourcing and restructuring, ignored job dissatisfaction among remaining employees which could reduce and or eliminate an airline's competitiveness. The purpose of this quantitative study was (a) to assess the relationship between increased levels of foreign-based MRO outsourcing and aviation professionals' job satisfaction (Y1); (b) to assess the influence of increased levels of foreign-based outsourcing on MRO control (Y2), MRO error rate (Y3), and MRO technical punctuality (Y4) as perceived by aviation professionals; and (c) to assess the influence of increased levels of foreign-based MRO outsourcing on technical skills (Y5) and morale ( Y6) as perceived by aviation professionals. The survey instrument was utilized based on Paul Spector's Job Satisfaction Questionnaire and MRO specific questions. A random sample of 300 U.S. airline participants was requested via MarketTools to meet required sample size of 110 as determined through a priori power analysis. Study data rendered 198 useable surveys of 213 total responses, and correlation, multiple regression, and ANOVA methods were used to test study hypotheses. The Spearman's rho for (Y 1) was statistically significant, p = .010 and multiple regression was statistically significant, p < .001. A one-way ANOVA indicated participants differed in their opinions of (Y2) through (Y6), Recommendations for future research include contrasting domestic and global MRO providers, and examining global aircraft parts suppliers and aviation technical training.

  20. Assessment of effects of atomoxetine in adult patients with ADHD: consistency among three geographic regions in a response maintenance study.

    Science.gov (United States)

    Tanaka, Yoko; Escobar, Rodrigo; Upadhyaya, Himanshu P

    2017-06-01

    A previous study (Upadhyaya et al. in Eur J Psychiatry 2013b; 27:185-205) reported that adults with attention-deficit/hyperactivity disorder (ADHD) demonstrated maintenance of response for up to 25 weeks after initially responding to atomoxetine treatment. In the present report, the consistency of treatment effect across three geographic regions (Europe, United States/Canada [US/Can], and Latin America [Latin Am]) was explored. Data were analyzed from a phase 3, multicenter, randomized, double-blind, maintenance-of-response (randomized withdrawal) trial of atomoxetine versus placebo in adults with ADHD. Patients were randomized to atomoxetine (N = 266) or placebo (N = 258) for 25 weeks. Consistency assessments included the interaction test, pairwise t tests, noninferiority, and the criteria from Basic Principles on Global Clinical Trials (Ministry of Health, Labour and Welfare of Japan 2007). Atomoxetine-treated patients maintained the improved ADHD symptoms relative to placebo-treated patients on the Conners' Adult ADHD Rating Scale Investigator-Rated: Screening Version 18-Item (CAARS-Inv:SV) total score in all three regions (atomoxetine-placebo mean difference = -4.55, -3.18, and -0.07 for Europe, US/Can, and Latin Am, respectively). For the Latin Am region, the mean change in total score (0.41) was notably smaller for the placebo group than for Europe (5.87) and US/Can (4.39). Similar results were observed for the CAARS-Inv:SV hyperactivity/impulsivity and inattention subscale scores. Overall, patients maintained the response with atomoxetine treatment compared to placebo; however, the magnitude of treatment effect differed among the regions studied, being numerically higher in the EU and US/Can than Latin Am. Trial registration http://www.clinicaltrials.gov/(NCT00700427 ).

  1. Sublingual Buprenorphine and Methadone Maintenance Treatment: A Three-Year Follow-Up of Quality of Life Assessment

    Directory of Open Access Journals (Sweden)

    Salvatore M. Giacomuzzi

    2005-01-01

    Full Text Available This study was conducted to compare long-term outcome effects on the quality of life (QOL of oral methadone with sublingual buprenorphine maintenance treatment. The QOL status of opioid-dependent patients was assessed using the German version (“Berlin Quality of Life Profile” of the Lancashire Quality of Life Profile. Physical symptoms were measured using the Opiate Withdrawal Scale (OWS. Urine tests were carried out randomly to detect additional consumption. In the first study period, 53 opioid-dependent subjects were enrolled and 25 could be reached after 3 years. The retention rate was 50% for methadone and 45% for buprenorphine (p = 0.786. Baseline values of the total sample (completers and noncompleters QOL and somatic complaints did not show significant differences between the two treatment groups. QOL characteristics at 6 months of treatment of the buprenorphine completer and noncompleter groups differed significantly regarding job (p = 0.013, family, and total score of physical symptoms (p = 0.002, in which the completer group showed the more favorable values. Concerning physical symptoms at 36 months, logistic regression revealed significantly less stomach cramps (p = 0.037 and fatigue and tiredness (p = 0.034 in buprenorphine compared to the methadone. Moreover, the buprenorphine-maintained group showed significantly less additional consumption of benzodiazepines (p = 0.015 compared with methadone participants. It is concluded that opioid addicts improved their QOL and health status when treated with methadone or buprenorphine. In summary, regarding QOL and health status, the present data indicate that buprenorphine is also a useful long-term alternative for maintenance treatment of opioid-dependent patients.

  2. Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2

    International Nuclear Information System (INIS)

    Wu, Hsien-Ming; Wang, Hsin-Shih; Huang, Hong-Yuan; Lai, Chyong-Huey; Lee, Chyi-Long; Soong, Yung-Kuei; Leung, Peter CK

    2013-01-01

    More than 25% of patients diagnosed with endometrial carcinoma have an invasive primary cancer accompanied by metastases. Gonadotropin-releasing hormone (GnRH) plays an important role in reproduction. In mammals, expression of GnRH-II is higher than GnRH-I in reproductive tissues. Here, we examined the effect of a GnRH-II agonist on the motility of endometrial cancer cells and its mechanism of action in endometrial cancer therapy. Immunoblotting and immunohistochemistry (IHC) were used to determine the expression of the GnRH-I receptor protein in human endometrial cancer. The activity of MMP-2 in the conditioned medium was determined by gelatin zymography. Cell motility was assessed by invasion and migration assay. GnRH-I receptor si-RNA was applied to knockdown GnRH-I receptor. The GnRH-I receptor was expressed in the endometrial cancer cells. The GnRH-II agonist promoted cell motility in a dose-dependent manner. The GnRH-II agonist induced the phosphorylation of ERK1/2 and JNK, and the phosphorylation was abolished by ERK1/2 inhibitor (U0126) and the JNK inhibitor (SP600125). Cell motility promoted by GnRH-II agonist was suppressed in cells that were pretreated with U0126 and SP600125. Moreover, U0126 and SP600125 abolished the GnRH-II agonist-induced activation of MMP-2. The inhibition of MMP-2 with MMP-2 inhibitor (OA-Hy) suppressed the increase in cell motility in response to the GnRH-II agonist. Enhanced cell motility mediated by GnRH-II agonist was also suppressed by the knockdown of the endogenous GnRH-I receptor using siRNA. Our study indicates that GnRH-II agonist promoted cell motility of endometrial cancer cells through the GnRH-I receptor via the phosphorylation of ERK1/2 and JNK, and the subsequent, MAPK-dependent activation of MMP-2. Our findings represent a new concept regarding the mechanism of GnRH-II-induced cell motility in endometrial cancer cells and suggest the possibility of exploring GnRH-II as a potential therapeutic target for the

  3. Development and Assessment of a 3D-Printed Scaffold with rhBMP-2 for an Implant Surgical Guide Stent and Bone Graft Material: A Pilot Animal Study

    OpenAIRE

    Bae, Ji Cheol; Lee, Jin-Ju; Shim, Jin-Hyung; Park, Keun-Ho; Lee, Jeong-Seok; Bae, Eun-Bin; Choi, Jae-Won; Huh, Jung-Bo

    2017-01-01

    In this study, a new concept of a 3D-printed scaffold was introduced for the accurate placement of an implant and the application of a recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded bone graft. This preliminary study was conducted using two adult beagles to evaluate the 3D-printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP)/bone decellularized extracellular matrix (bdECM) scaffold conjugated with rhBMP-2 for the simultaneous use as an implant surgical guide stent an...

  4. New superconductor LaRhSb

    International Nuclear Information System (INIS)

    Nishigori, S.; Moriwaki, H.; Suzuki, T.; Fujita, T.; Tanaka, H.; Takabatake, T.; Fujii, H.

    1994-01-01

    Superconductivity in LaRhSb was newly found below the transition temperature T c = 2.67 K by the measurements of the electrical resistivity, magnetic susceptibility and specific heat in magnetic fields. The characteristics of the superconductivity determined in this study indicate that LaRhSb is a type II superconductor following the BCS theory. (orig.)

  5. Rh-catalyzed linear hydroformylation of styrene

    NARCIS (Netherlands)

    Boymans, E.H.; Janssen, M.C.C.; Mueller, C.; Lutz, M.; Vogt, D.

    2012-01-01

    Usually the Rh-catalyzed hydroformylation of styrene predominantly yields the branched, chiral aldehyde. An inversion of regioselectivity can be achieved using strong p-acceptor ligands. Binaphthol-based diphosphite and bis(dipyrrolyl-phosphorodiamidite) ligands were applied in the Rh-catalyzed

  6. Status of reliability in determining SDDR for manual maintenance activities in ITER: Quality assessment of relevant activation cross sections involved

    International Nuclear Information System (INIS)

    Garcia, R.; Garcia, M.; Pampin, R.; Sanz, J.

    2016-01-01

    Highlights: • Feasibility of manual maintenance activities in ITER port cell and port interspace. • Activation of relevant materials and components placed in the current ITER model. • Dominant radionuclides and pathways for shutdown dose rate in ITER. • Quality analysis of typically used EAF and TENDL activation libraries is performed. • EAF performance found as trustworthy with slight recommended improvements. - Abstract: This paper assesses the quality of the EAF-2007 and 2010 activation cross sections for relevant reactions in the determination of the Shutdown Dose Rate (SDDR) in the Port Cell (PC) and Port Interspace (PI) areas of ITER. For each of relevant ITER materials, dominant radionuclides responsible of SDDR and their production pathways are listed. This information comes from a review of the recent reports/papers about SDDR in ITER and own calculations. A total of 26 relevant pathways are found. The quality of these cross sections pathways is assessed following EAF validation procedure, and for those found as not validated last TENDL library versions have been investigated in order to check possible improvements when compared to EAF. The use of EAF libraries is found as trustworthy and it is recommended for the prediction of SDDR in the ITER PC and PI. However, 3 cross section reactions are considered for further improvement: Co59(n,2n)Co58, Cu63(n,g)Cu64 and Cr50(n,g)Cr51.

  7. Status of reliability in determining SDDR for manual maintenance activities in ITER: Quality assessment of relevant activation cross sections involved

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, R., E-mail: rgarciam@ind.uned.es [UNED, Power Engineering Department, C/Juan del Rosal 12, 28040 Madrid (Spain); Garcia, M. [UNED, Power Engineering Department, C/Juan del Rosal 12, 28040 Madrid (Spain); Pampin, R. [F4E, Torres Diagonal Litoral B3, Barcelona (Spain); Sanz, J. [UNED, Power Engineering Department, C/Juan del Rosal 12, 28040 Madrid (Spain)

    2016-11-15

    Highlights: • Feasibility of manual maintenance activities in ITER port cell and port interspace. • Activation of relevant materials and components placed in the current ITER model. • Dominant radionuclides and pathways for shutdown dose rate in ITER. • Quality analysis of typically used EAF and TENDL activation libraries is performed. • EAF performance found as trustworthy with slight recommended improvements. - Abstract: This paper assesses the quality of the EAF-2007 and 2010 activation cross sections for relevant reactions in the determination of the Shutdown Dose Rate (SDDR) in the Port Cell (PC) and Port Interspace (PI) areas of ITER. For each of relevant ITER materials, dominant radionuclides responsible of SDDR and their production pathways are listed. This information comes from a review of the recent reports/papers about SDDR in ITER and own calculations. A total of 26 relevant pathways are found. The quality of these cross sections pathways is assessed following EAF validation procedure, and for those found as not validated last TENDL library versions have been investigated in order to check possible improvements when compared to EAF. The use of EAF libraries is found as trustworthy and it is recommended for the prediction of SDDR in the ITER PC and PI. However, 3 cross section reactions are considered for further improvement: Co59(n,2n)Co58, Cu63(n,g)Cu64 and Cr50(n,g)Cr51.

  8. A study of clinical assessment of frailty in patients on maintenance hemodialysis supported by cashless government scheme

    Directory of Open Access Journals (Sweden)

    Manjusha Yadla

    2017-01-01

    Full Text Available This is a prospective cohort study to assess the prevalence of frailty in patients undergoing maintenance hemodialysis (HD under the government-funded scheme at our center and to assess the relationship between frailty and falls, hospitalizations, and mortality. This was done at our center which is completely supported by the government, which provides HD to all the patients under poverty line. Epidemiological data, anthropometric measurements, comorbidities assessment, frailty assessment using Fried criteria, subsequent hospitalizations, falls, and mortality were recorded in our prevalent dialysis population at our center between October 2014 and October 2015. Two hundred and twenty-six patients were enrolled during this period. Twenty-one patients were excluded as they did not satisfy the inclusion criteria. Two hundred and five prospective patients were studied for the predictors of frailty. Frailty was present in 82% of the study population. Mean age of our study population was 44.95 ± 13.27 years. On univariate analysis, diabetes mellitus, hypertension (HTN, cerebrovascular accident (CVA, left ventricular dysfunction (LVD, peripheral vascular disease (PVD, smoking, hepatitis C, inadequate dialysis, intradialytic hypotension (IDH, interdialytic weight gain, low serum creatinine <4 mg/dL, and anemia (Hb <10 g/dL were found to be statistically significantly different between frail and nonfrail groups On multivariate regression analysis, only HTN, PVD, CVA, anemia, smoking, and IDH were found to be significant. Frailty is highly prevalent among dialysis population. Factors predicting frailty include HTN, smoking, LVD, PVD, CVA, smoking, anemia, and IDH. Frailty is a significant risk factor for falls and hospitalizations.

  9. A comparative DFT study on the dehydrogenation of methanol on Rh(100) and Rh(110)

    Science.gov (United States)

    Zhang, Minhua; Wu, Xingyu; Yu, Yingzhe

    2018-04-01

    Numerous density functional theory calculations have been performed to investigate the complete mechanisms of methanol dehydrogenation on Rh(100) and Rh(110) surfaces. The adsorption properties of relevant species were discussed in details. In addition, a comprehensive reaction network including four reaction pathways was built and analyzed. It is found that the initial Osbnd H bond scission of CH3OH seems to be more favorable than Csbnd H bond cleavage on both Rh(100) and Rh(110) surfaces from the perspective of activation barriers. It is also concluded that path1 (CH3OH → CH3O → CH2O → CHO → CO) is the predominant pathway on both Rh(100) and Rh (110) surfaces. On the whole, in most of the dehydrogenation reactions investigated, the energy barriers on Rh(100) are lower than those on Rh (110). Remarkable differences in the activity and predominant reaction pathway on Rh(100), Rh(110) and Rh(111) indicate that the dehydrogenation of methanol might be structure-sensitive.

  10. Development and Assessment of a 3D-Printed Scaffold with rhBMP-2 for an Implant Surgical Guide Stent and Bone Graft Material: A Pilot Animal Study

    Directory of Open Access Journals (Sweden)

    Ji Cheol Bae

    2017-12-01

    Full Text Available In this study, a new concept of a 3D-printed scaffold was introduced for the accurate placement of an implant and the application of a recombinant human bone morphogenetic protein-2 (rhBMP-2-loaded bone graft. This preliminary study was conducted using two adult beagles to evaluate the 3D-printed polycaprolactone (PCL/β-tricalcium phosphate (β-TCP/bone decellularized extracellular matrix (bdECM scaffold conjugated with rhBMP-2 for the simultaneous use as an implant surgical guide stent and bone graft material that promotes new bone growth. Teeth were extracted from the mandible of the beagle model and scanned by computed tomography (CT to fabricate a customized scaffold that would fit the bone defect. After positioning the implant guide scaffold, the implant was placed and rhBMP-2 was injected into the scaffold of the experimental group. The two beagles were sacrificed after three months. The specimen block was obtained and scanned by micro-CT. Histological analysis showed that the control and experimental groups had similar new bone volume (NBV, % but the experimental group with BMP exhibited a significantly higher bone-to-implant contact ratio (BIC, %. Within the limitations of this preliminary study, a 3D-printed scaffold conjugated with rhBMP-2 can be used simultaneously as an implant surgical guide and a bone graft in a large bone defect site. Further large-scale studies will be needed to confirm these results.

  11. Development and Assessment of a 3D-Printed Scaffold with rhBMP-2 for an Implant Surgical Guide Stent and Bone Graft Material: A Pilot Animal Study

    Science.gov (United States)

    Bae, Ji Cheol; Lee, Jin-Ju; Shim, Jin-Hyung; Park, Keun-Ho; Lee, Jeong-Seok; Bae, Eun-Bin; Choi, Jae-Won; Huh, Jung-Bo

    2017-01-01

    In this study, a new concept of a 3D-printed scaffold was introduced for the accurate placement of an implant and the application of a recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded bone graft. This preliminary study was conducted using two adult beagles to evaluate the 3D-printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP)/bone decellularized extracellular matrix (bdECM) scaffold conjugated with rhBMP-2 for the simultaneous use as an implant surgical guide stent and bone graft material that promotes new bone growth. Teeth were extracted from the mandible of the beagle model and scanned by computed tomography (CT) to fabricate a customized scaffold that would fit the bone defect. After positioning the implant guide scaffold, the implant was placed and rhBMP-2 was injected into the scaffold of the experimental group. The two beagles were sacrificed after three months. The specimen block was obtained and scanned by micro-CT. Histological analysis showed that the control and experimental groups had similar new bone volume (NBV, %) but the experimental group with BMP exhibited a significantly higher bone-to-implant contact ratio (BIC, %). Within the limitations of this preliminary study, a 3D-printed scaffold conjugated with rhBMP-2 can be used simultaneously as an implant surgical guide and a bone graft in a large bone defect site. Further large-scale studies will be needed to confirm these results. PMID:29258172

  12. Implementation Guideline for Maintenance Line Operations Safety Assessment (M-LOSA) and Ramp LOSA (R-LOSA) Programs

    Science.gov (United States)

    2012-08-01

    Maintenance and/or Ramp LOSA)  Database  Observation protocol 16 hours; in person with hands-on observation and database practice 4. LOSA Database...Forms/Scenarios (Maintenance and/or Ramp LOSA)  Database  Observation protocol  Q&A Every year or every implementation run (whichever

  13. Regulatory inspection activities related to inspection planning, plant maintenance and assessment of safety. Proceedings of an international workshop

    Energy Technology Data Exchange (ETDEWEB)

    Van Binnebeek, J. J. [AIB-Vincotte Nuclear - AVN, Avenue du Roi, 157, B-1060 Brussels (Belgium); Aubrey, Richard; Grandame, Melvyn [Atomic Energy Control Board - AECB, P.O. Box 1046, Station B, 280 Slater Street, Ottawa, Ontario K1P 5S9 (Canada); Aro, Ilari [Finnish Centre for Radiation and Nuclear Safety - STUK, P.O. Box 14, FIN-00881 Helsinki (Finland); Balloffet, Yves [DRIRE Rhone Alpes, 146, rue Pierre Corneille, 69426 Lyon CEDEX 03 (France); Klonk, Hartmut [Bundesamt fuer Strahlenschutz - BfS, Federal Office for Radiation Protection, Postbox 10 01 49, 38201 Salzgitter 1 (Germany); Manzella, Pietro [A.N.P.A., Via V. Brancati, 48, 1-00144 Roma EUR (Italy); Koizumi, Hiroyoshi [Tech. Stan. Dept. - JAPEIC, Shin-Toranomon Bldg., 1-5-11, Akasaka, Minato-ku, Tokyo 107 (Japan); Bouvrie, E.C. des [Ministry of Social Affairs and Employment, Nuclear Safety Dept. KFD, P.O. Box 90804, 2509 LV The Hague (Netherlands); Forsberg, Staffan [Swedish Nuclear Power Inspectorate - SKI, Klarabergsviadukten 90, S-10658 Stockholm (Sweden); Lang, Hans-Guenter [Section Plant Coordination and Inspection, Swiss Federal Nuclear Safety Inspectorate - HSK, CH-5232 Villigen-HSK (Switzerland); Mehew, Robert; Warren, Thomas; Woodhouse, Paul [Health and Safety Executive - NII, St. Peter' s House, Balliol Road, Bootle, Merseyside L20 3LZ (United Kingdom); Gallo, Robert M. [Special Inspection Branch, US Nuclear Regulatory Commission - US NRC, Mail Stop 0-9A1, Washington, DC 20555 (United States); Campbell, Rob [International Atomic Energy Agency - IAEA, P.O. Box 100, A-1400 Vienna (International Atomic Energy Agency (IAEA))

    1997-07-01

    The NEA Committee on Nuclear Regulatory Activities (CNRA) believes that an essential factor in ensuring the safety of nuclear installations is the continuing exchange and analysis of technical information and data. To facilitate this exchange the Committee has established Working Groups and Groups of Experts in specialised topics. CNRA believes that safety inspections are a major element in the regulatory authority's efforts to ensure the safe operation of nuclear facilities. Considering the importance of these issues, the Committee has established a special Working Group on Inspection Practices (WGIP). The purpose of WGIP, is to facilitate the exchange of information and experience related to regulatory safety inspections between CNRA Member countries. This was the 3. international workshop held by the WGIP on regulatory inspection activities. The focus of this workshop was on 3 main topics; Inspection Planning, Plant Maintenance and Assessment of Safety. This document presents the proceedings from the workshop, including: workshop programme, results and conclusions, papers and presentations and the list of participants. The main purpose of the Workshop is to provide a forum of exchange of information on the regulatory inspection activities.

  14. Regulatory inspection activities related to inspection planning, plant maintenance and assessment of safety. Proceedings of an international workshop

    International Nuclear Information System (INIS)

    Van Binnebeek, J.J.; Aubrey, Richard; Grandame, Melvyn; Aro, Ilari; Balloffet, Yves; Klonk, Hartmut; Manzella, Pietro; Koizumi, Hiroyoshi; Bouvrie, E.C. des; Forsberg, Staffan; Lang, Hans-Guenter; Mehew, Robert; Warren, Thomas; Woodhouse, Paul; Gallo, Robert M.; Campbell, Rob; )

    1997-01-01

    The NEA Committee on Nuclear Regulatory Activities (CNRA) believes that an essential factor in ensuring the safety of nuclear installations is the continuing exchange and analysis of technical information and data. To facilitate this exchange the Committee has established Working Groups and Groups of Experts in specialised topics. CNRA believes that safety inspections are a major element in the regulatory authority's efforts to ensure the safe operation of nuclear facilities. Considering the importance of these issues, the Committee has established a special Working Group on Inspection Practices (WGIP). The purpose of WGIP, is to facilitate the exchange of information and experience related to regulatory safety inspections between CNRA Member countries. This was the 3. international workshop held by the WGIP on regulatory inspection activities. The focus of this workshop was on 3 main topics; Inspection Planning, Plant Maintenance and Assessment of Safety. This document presents the proceedings from the workshop, including: workshop programme, results and conclusions, papers and presentations and the list of participants. The main purpose of the Workshop is to provide a forum of exchange of information on the regulatory inspection activities

  15. A Life Cycle Assessment Framework for Pavement Maintenance and Rehabilitation Technologies : or An Integrated Life Cycle Assessment (LCA) – Life Cycle Cost Analysis (LCCA) Framework for Pavement Maintenance and Rehabilitation

    Science.gov (United States)

    2018-02-01

    Qing Lu (ORCID ID 0000-0002-9120-9218) Given a huge amount of annual investment and large inputs of energy and natural resources in pavement maintenance and rehabilitation (M&R) activities, significant environmental improvement and budget saving can ...

  16. Assessment of diagnostic and prognostic condition indices for efficient and robust maintenance decision-making of systems subject to stress corrosion cracking

    International Nuclear Information System (INIS)

    Huynh, K.T.; Grall, A.; Bérenguer, C.

    2017-01-01

    Seeking condition indices characterizing the health state of a system is a key problem in condition-based maintenance. For this purpose, diagnostic and prognostic models have been unceasingly developed and improved over the past few decades; nevertheless none of them explains thoroughly the impacts of such indices on the effectiveness of maintenance operations. As a complement to these efforts, this paper analyzes the effectiveness of some well-known diagnostic and prognostic indices for maintenance decision-making. The study is based on a system subject to competing risks due to multiple crack paths. A periodic inspection scheme is used to monitor the system health state. Each inspection returns the perfect diagnostic information: the number of cracks, corresponding crack sizes, and the system failure/working state. Based on this information, two kinds of prognostic condition indices are predicted: the average value and probability law of the system residual useful life. The associated condition-based maintenance strategies and cost models are then developed and compared with the ones whose maintenance decisions are based on diagnostic condition indices. The comparison results allow us to conclude on the performance and on the robustness of these strategies, hence giving some suggestions on the choice of reliable condition indices for maintenance decision-making. - Highlights: • Developing a new and generic degradation and failure model. • Synthesizing diagnostic and prognostic condition indices on the basis of the developed degradation and failure model. • Building diagnosis and prognosis-based maintenance strategies, and developing the associated cost models. • Assessing the performance and robustness of the considered strategies to find out reliable indices.

  17. Rh-flash acquisition card

    International Nuclear Information System (INIS)

    Bourrion, O.

    2003-01-01

    The rh-flash card main purpose is to convert and store the image of the analog data present at input into an output buffer, namely in a given timing window besides a stop signal (like a digital oscilloscope). It is conceived in VME format 1U wide with an additional connector. Novelty of this card is its ability to sample at a high frequency, due to flash coders, and this at a high repetition rate. To do that the card allows the storage of the data considered 'useful' and that is done by storing only the data exceeding a certain threshold. This can be useful for instance for viewing peaks in a spectrum, and obtaining their relative location. The goal is to stock and process the data sampled before and after the arrival of a stop signal (what entails a storage depth). A threshold is defined and any peak exceeding its level will really be stored in the output buffer which is readable through the VME bus. The peak values will be stored as well as m preceding and n subsequent values (both programmable). Obviously, if the threshold is zero the system of data processing is off and all data will be stored. The document is structured on six sections titled: 1. Description; 2. Specifications; 3. Explaining the design of channels; 4. Explaining the shared part of the design; 5. Addressing (→ user guide); 6. Software precautions. (author)

  18. Preventative Maintenance.

    Science.gov (United States)

    Migliorino, James

    Boards of education must be convinced that spending money up front for preventive maintenance will, in the long run, save districts' tax dollars. A good program of preventive maintenance can minimize disruption of service; reduce repair costs, energy consumption, and overtime; improve labor productivity and system equipment reliability; handle…

  19. Maintenance action readiness assessment plan for White Oak Creek and Melton Branch Weir Stilling Pool cleanout at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    1995-08-01

    This Readiness Assessment Plan has been prepared to document operational readiness for the following maintenance action: (1) removal of sediment from the White Oak Creek and Melton Branch Weir Stilling Pools and (2) disposal of the radiologically contaminated sediment in another location upstream of the weirs in an area previously contaminated by stream overflow from Melton Branch in Waste Area Grouping 2 (WAG) at Oak Ridge National Laboratory. This project is being performed as a maintenance action rather than an action under the Comprehensive Environmental Response, Compensation, and Liability Act because the risk to human health and environment is well below the US Environmental Protection Agency's level of concern. The decision to proceed as a maintenance action was documented by an interim action proposed plan, which is included in the administrative record. The administrative record is available for review at the US Department of Energy Information Resource Center, 105 Broadway Avenue, Oak Ridge, Tennessee 37830

  20. The role of affect in the maintenance of anorexia nervosa: evidence from a naturalistic assessment of momentary behaviors and emotion.

    Science.gov (United States)

    Engel, Scott G; Wonderlich, Stephen A; Crosby, Ross D; Mitchell, James E; Crow, Scott; Peterson, Carol B; Le Grange, Daniel; Simonich, Heather K; Cao, Li; Lavender, Jason M; Gordon, Kathryn H

    2013-08-01

    The current study examines the relationship of affect and eating disorder behavior in anorexia nervosa (AN) using ecological momentary assessment. Participants were 118 adult females recruited at three sites from eating disorder treatment centers and community advertisements. All participants met full Diagnostic and statistical manual of mental disorders (4th ed.) criteria or subthreshold criteria for AN. Participants were provided handheld computers and asked to report positive affect, negative affect, loss of control (LOC) eating, purging, exercise, drinking fluids to curb appetite, and weighing one's self multiple times per day as well as dietary restriction once daily over a 2-week interval. Mixed-effects models were used to examine the extent to which affective states predict dietary restriction. In addition, we used two analytic approaches to compare affect before and after other eating disorder behaviors. We found that higher daily ratings of negative affect were associated with a greater likelihood of dietary restriction on subsequent days. When examining the single rating immediately before and after behaviors, we found that negative affect increased significantly after LOC eating, purging, the combination of LOC and eating/purging, and weighing of one's self. Using this same analytic approach, we also found negative affect to decrease significantly after the consumption of fluids to curb appetite and exercise. When examining the covariation of AN behaviors and negative affect assessed multiple times in the hours and minutes before the behaviors, we found negative affect significantly increased before LOC eating, purging, the combination of LOC eating/and purging, and weighing behavior. Negative affect also significantly decreased after the occurrence of these behaviors. These findings are consistent with the idea that that negative affect is potentially a critical maintenance mechanism of some AN symptoms, but that the analytic approach used to examine

  1. Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen Report.

    Directory of Open Access Journals (Sweden)

    Mirko Manchia

    Full Text Available The assessment of response to lithium maintenance treatment in bipolar disorder (BD is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the "Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" scale currently used in the Consortium on Lithium Genetics (ConLiGen study.Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ] and reliability [intra-class correlation coefficient (ICC] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling.Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively, without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively. Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders.We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.

  2. Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report

    Science.gov (United States)

    Manchia, Mirko; Adli, Mazda; Akula, Nirmala; Ardau, Raffaella; Aubry, Jean-Michel; Backlund, Lena; Banzato, Claudio EM.; Baune, Bernhard T.; Bellivier, Frank; Bengesser, Susanne; Biernacka, Joanna M.; Brichant-Petitjean, Clara; Bui, Elise; Calkin, Cynthia V.; Cheng, Andrew Tai Ann; Chillotti, Caterina; Cichon, Sven; Clark, Scott; Czerski, Piotr M.; Dantas, Clarissa; Zompo, Maria Del; DePaulo, J. Raymond; Detera-Wadleigh, Sevilla D.; Etain, Bruno; Falkai, Peter; Frisén, Louise; Frye, Mark A.; Fullerton, Jan; Gard, Sébastien; Garnham, Julie; Goes, Fernando S.; Grof, Paul; Gruber, Oliver; Hashimoto, Ryota; Hauser, Joanna; Heilbronner, Urs; Hoban, Rebecca; Hou, Liping; Jamain, Stéphane; Kahn, Jean-Pierre; Kassem, Layla; Kato, Tadafumi; Kelsoe, John R.; Kittel-Schneider, Sarah; Kliwicki, Sebastian; Kuo, Po-Hsiu; Kusumi, Ichiro; Laje, Gonzalo; Lavebratt, Catharina; Leboyer, Marion; Leckband, Susan G.; López Jaramillo, Carlos A.; Maj, Mario; Malafosse, Alain; Martinsson, Lina; Masui, Takuya; Mitchell, Philip B.; Mondimore, Frank; Monteleone, Palmiero; Nallet, Audrey; Neuner, Maria; Novák, Tomás; O’Donovan, Claire; Ösby, Urban; Ozaki, Norio; Perlis, Roy H.; Pfennig, Andrea; Potash, James B.; Reich-Erkelenz, Daniela; Reif, Andreas; Reininghaus, Eva; Richardson, Sara; Rouleau, Guy A.; Rybakowski, Janusz K.; Schalling, Martin; Schofield, Peter R.; Schubert, Oliver K.; Schweizer, Barbara; Seemüller, Florian; Grigoroiu-Serbanescu, Maria; Severino, Giovanni; Seymour, Lisa R.; Slaney, Claire; Smoller, Jordan W.; Squassina, Alessio; Stamm, Thomas; Steele, Jo; Stopkova, Pavla; Tighe, Sarah K.; Tortorella, Alfonso; Turecki, Gustavo; Wray, Naomi R.; Wright, Adam; Zandi, Peter P.; Zilles, David; Bauer, Michael; Rietschel, Marcella; McMahon, Francis J.

    2013-01-01

    Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the “Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder” scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. Materials and Methods Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling. Results Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders). Conclusions We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study. PMID:23840348

  3. 103Ru/103mRh generator

    International Nuclear Information System (INIS)

    Bartos, B.; Kowalska, E.; Bilewicz, A.; Skarnemark, G.

    2009-01-01

    103m Rh is a very promising radionuclide for Auger electron therapy due to its very low photon/electron ratio. The goal of the present work was the elaboration a method for production of large quantities of 103m Rh for generator system. It was found that the combination of solvent extraction with evaporation of 103 RuO 4 followed by decomposition of H 5 IO 6 makes it possible to produce 103m Rh of high radionuclidic and chemical purity. (author)

  4. Scattering of fast neutrons from 103Rh

    International Nuclear Information System (INIS)

    Barnard, E.; Reitmann, D.

    1978-01-01

    The scattering of fast neutrons from 103 Rh was studied by means of (n, n), (n, n') and (n, n'γ) measurements at neutron energies up to 2 MeV. More than fifty unknown γ-transitions were identified and a level scheme established which includes fifteen unreported excited states. Branching ratios, spins and parities for these levels were deduced, as well as the effective activation cross sections for the 103 Rh(n, n')sup(103m)Rh reaction. The results are compared with existing data and with calculations based on the optical and statistical models. (Auth.)

  5. Reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD negative women

    DEFF Research Database (Denmark)

    Clausen, Frederik Banch; Krog, Grethe Risum; Rieneck, Klaus

    2005-01-01

    The objective of this study was to establish a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD negative women. This test is needed for future prenatal Rh prophylaxis.......The objective of this study was to establish a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD negative women. This test is needed for future prenatal Rh prophylaxis....

  6. Assessing the potential spread and maintenance of foot-and-mouth disease virus infection in wild ungulates: general principles and application to a specific scenario in Thrace

    DEFF Research Database (Denmark)

    Dhollander, S.; Belsham, Graham; Lange, M.

    2016-01-01

    Foot-and-mouth disease (FMD), due to infection with serotype O virus, occurred in wild boar and within eleven outbreaks in domestic livestock in the south-east of Bulgaria, Thrace region, in 2011. Hence, the issue of the potential for the spread and maintenance of FMD virus (FMDV) infection...... in a population of wild ungulates became important. This assessment focused on the spread and maintenance of FMDV infection within a hypothetical wild boar and deer population in an environment, which is characterized by a climate transitional between Mediterranean and continental and variable wildlife population...... densities. The assessment was based on three aspects: (i) a systematic review of the literature focusing on experimental infection studies to identify the parameters describing the duration of FMDV infection in deer and wild boar, as well as observational studies assessing the occurrence of FMDV infection...

  7. Absolute calibration of the Rh-103(n,n')Rh-103m reaction rate

    International Nuclear Information System (INIS)

    Taylor, W.H.; Murphy, M.F.; March, M.R.

    1979-05-01

    The uncertainties in determining the absolute values of the Rh-103(n, n') Rh-103m reaction rate (which is widely used as a neutron damage flux monitor) have been reduced to approximately +-5%. This has been achieved with the use of a calibrated source of Pd-103-Rh-103m activity supplied by the IAEA. Agreement to within 3% between measured and calculated values of the reaction rate (normalised to the U-238 fission rate) has been achieved. (author)

  8. Impact of a confirmatory RhD test on the correct serologic typing of blood donors

    Directory of Open Access Journals (Sweden)

    Luciana Cayres Schmidt

    2015-10-01

    Full Text Available BACKGROUND: The RHD gene is highly polymorphic, which results in a large number of RhD variant phenotypes. Discrepancies in RhD typing are still a problem in blood banks and increase the risk of alloimmunization. In this study, the RhD typing strategy at a blood bank in Brazil was evaluated.METHODS: One-hundred and fifty-two samples typed as RhD negative and C or E positive by routine tests (automated system and indirect antiglobulin test using the tube technique were reevaluated for RhD status by three methods. The method with the best performance was implemented and evaluated for a period of one year (n = 4897 samples. Samples that were D positive exclusively in the confirmatory test were submitted to molecular analysis.RESULTS: The gel test for indirect antiglobulin testing with anti-D immunoglobulin G (clone ESD1 presented the best results. Seventy samples (1.43% previously typed as RhD negative showed reactivity in the gel test for indirect antiglobulin testing and were reclassified as D positive. D variants that may cause alloimmunization, such as weak D type 2 and partial DVI, were detected.CONCLUSION: The confirmatory RhD test using the gel test for indirect antiglobulin testing represents a breakthrough in transfusion safety in this blood center. Our results emphasize the importance of assessing the blood group typing strategy in blood banks.

  9. Pregnancy outcome of “delayed start” GnRH antagonist protocol versus GnRH antagonist protocol in poor responders: A clinical trial study

    Directory of Open Access Journals (Sweden)

    Abbas Aflatoonian

    2017-08-01

    Full Text Available Background: Management of poor-responding patients is still major challenge in assisted reproductive techniques (ART. Delayed-start GnRH antagonist protocol is recommended to these patients, but little is known in this regards. Objective: The goal of this study was assessment of delayed-start GnRH antagonist protocol in poor responders, and in vitro fertilization (IVF outcomes. Materials and Methods: This randomized clinical trial included sixty infertile women with Bologna criteria for ovarian poor responders who were candidate for IVF. In case group (n=30, delayed-start GnRH antagonist protocol administered estrogen priming followed by early follicular-phase GnRH antagonist treatment for 7 days before ovarian stimulation with gonadotropin. Control group (n=30 treated with estrogen priming antagonist protocol. Finally, endometrial thickness, the rates of oocytes maturation, , embryo formation, and pregnancy were compared between two groups. Results: Rates of implantation, chemical, clinical, and ongoing pregnancy in delayed-start cycles were higher although was not statistically significant. Endometrial thickness was significantly higher in case group. There were no statistically significant differences in the rates of oocyte maturation, embryo formation, and IVF outcomes between two groups. Conclusion: There is no significant difference between delayed-start GnRH antagonist protocol versus GnRH antagonist protocol.

  10. Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats

    International Nuclear Information System (INIS)

    Olberg, Dag E.; Bauer, Nadine; Andressen, Kjetil W.; Hjørnevik, Trine; Cumming, Paul; Levy, Finn O.; Klaveness, Jo; Haraldsen, Ira; Sutcliffe, Julie L.

    2016-01-01

    Introduction: The gonadotropin releasing hormone receptor (GnRH-R) has a well-described neuroendocrine function in the anterior pituitary. However, little is known about its function in the central nervous system (CNS), where it is most abundantly expressed in hippocampus and amygdala. Since peptide ligands based upon the endogenous decapetide GnRH do not pass the blood–brain-barrier, we are seeking a high-affinity small molecule GnRH-R ligand suitable for brain imaging by positron emission tomography. We have previously reported the radiosynthesis and in vitro evaluation of two novel [ 18 F]fluorinated GnRH-R ligands belonging to the furamide class of antagonists, with molecular weight less than 500 Da. We now extend this work using palladium coupling for the synthesis of four novel radioligands, with putatively reduced polar surface area and hydrophilicity relative to the two previously described compounds, and report the uptake of these 18 F-labeled compounds in brain of living rats. Methods: We synthesized reference standards of the small molecule GnRH-R antagonists as well as mesylate precursors for 18 F-labeling. The antagonists were tested for binding affinity for both human and rat GnRH-R. Serum and blood stability in vitro and in vivo were studied. Biodistribution and PET imaging studies were performed in male rats in order to assess brain penetration in vivo. Results: A palladium coupling methodology served for the synthesis of four novel fluorinated furamide GnRH receptor antagonists with reduced heteroatomic count. Radioligand binding assays in vitro revealed subnanomolar affinity of the new fluorinated compounds for both human and rat GnRH-R. The 18 F-GnRH antagonists were synthesized from the corresponding mesylate precursors in 5–15% overall radiochemical yield. The radiolabeled compounds demonstrated good in vivo stability. PET imaging with the 18 F-radiotracers in naive rats showed good permeability into brain and rapid washout, but absence of

  11. Comparison of long GnRH agonist versus GnRH antagonist protocol in poor responders

    Directory of Open Access Journals (Sweden)

    Sadık Şahin

    2014-12-01

    Full Text Available Objective: To compare long GnRH agonist with GnRH antagonist protocol in poor responders. Materials and Methods: Medical charts of 531 poor responder women undergoing in-vitro fertilization (IVF cycle at Zeynep Kamil Maternity and Children’s Hospital, IVF Center were retrospectively analysed. Those who received at least 300 IU/daily gonadotropin and had ≤3 oocytes retrieved were enrolled in the study. Poor responders were categorized into two groups as those who received long GnRH agonist or GnRH antagonist regimen. Results: Treatment duration and total gonadotropin dosage were significantly higher in women undergoing the long GnRH agonist regimen compared with the GnRH antagonist regimen (p<0.001 for both. Although the number of total and mature oocytes retrieved was similar between the groups, good quality embryos were found to be higher in the GnRH antagonist regimen. The day of embryo transfer and number of transferred embryos were similar in the groups. No statistically significant differences were detected in pregnancy (10.5% vs 14.1%, clinical pregnancy (7.7% vs 10.6% and early pregnancy loss rates (27.2% vs 35% between the groups. Conclusion: GnRH antagonist regimen may be preferable to long GnRH regimen as it could decrease the cost and treatment duration in poor responders.

  12. Non-invasive assessment of the reproductive cycle in free-ranging female African elephants (Loxodonta africana treated with a gonadotropin-releasing hormone (GnRH vaccine for inducing anoestrus

    Directory of Open Access Journals (Sweden)

    Benavides Valades Gabriela

    2012-08-01

    Full Text Available Abstract Background In southern Africa, various options to manage elephant populations are being considered. Immunocontraception is considered to be the most ethically acceptable and logistically feasible method for control of smaller and confined populations. In this regard, the use of gonadotropin-releasing hormone (GnRH vaccine has not been investigated in female elephants, although it has been reported to be safe and effective in several domestic and wildlife species. The aims of this study were to monitor the oestrous cycles of free-ranging African elephant cows using faecal progestagen metabolites and to evaluate the efficacy of a GnRH vaccine to induce anoestrus in treated cows. Methods Between May 2009 - June 2010, luteal activity of 12 elephant cows was monitored non-invasively using an enzyme immunoassay detecting faecal 5alpha-reduced pregnanes (faecal progestagen metabolites, FPM on a private game reserve in South Africa. No bulls of breeding age were present on the reserve prior to and for the duration of the study. After a 3-month control period, 8 randomly-selected females were treated twice with 600 micrograms of GnRH vaccine (Improvac®, Pfizer Animal Health, Sandton, South Africa 5-7 weeks apart. Four of these females had been treated previously with the porcine zona pellucida (pZP vaccine for four years (2004-2007. Results All 12 monitored females (8 treated and 4 controls showed signs of luteal activity as evidenced by FPM concentrations exceeding individual baseline values more than once. A total of 16 oestrous cycles could be identified in 8 cows with four of these within the 13 to 17 weeks range previously reported for captive African elephants. According to the FPM concentrations the GnRH vaccine was unable to induce anoestrus in the treated cows. Overall FPM levels in samples collected during the wet season (mean 4.03 micrograms/gram dry faeces were significantly higher (P Conclusions The GnRH vaccination protocol failed

  13. Maintenance Mentor

    National Research Council Canada - National Science Library

    Jacobs, John

    2003-01-01

    Maintenance Mentor (MXM) is a research effort conducted by a joint AFRL/HESR and Northrop Grumman Information Technology team to identify the basic, high-level requirements necessary for improving flight line diagnostic capabilities...

  14. An electro-hydraulic servo control system research for CFETR blanket RH

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Changqi [Hefei University of Technology, Hefei 230009, Anhui (China); Tang, Hongjun, E-mail: taurustang@126.com [Hefei University of Technology, Hefei 230009, Anhui (China); Qi, Songsong [Hefei University of Technology, Hefei 230009, Anhui (China); Cheng, Yong; Feng, Hansheng; Peng, Xuebing; Song, Yuntao [Institute of Plasma Physics Chinese Academy of Sciences, Hefei 230031, Anhui (China)

    2014-11-15

    Highlights: • We discussed the conceptual design of CFETR blanket RH maintenance system. • The mathematical model of electro-hydraulic servo system was calculated. • A fuzzy adaptive PD controller was designed based on control theory and experience. • The co-simulation models of the system were established with AMESim/Simulink. • The fuzzy adaptive PD algorithm was designed as the core strategy of the system. - Abstract: Based on the technical design requirements of China Fusion Engineering Test Reactor (CFETR) blanket remote handling (RH) maintenance, this paper focus on the control method of achieving high synchronization accuracy of electro-hydraulic servo system. Based on fuzzy control theory and practical experience, a fuzzy adaptive proportional-derivative (PD) controller was designed. Then a more precise co-simulation model was established with AMESim/Simulink. Through the analysis of simulation results, a fuzzy adaptive PD control algorithm was designed as the core strategy of electro-hydraulic servo control system.

  15. An electro-hydraulic servo control system research for CFETR blanket RH

    International Nuclear Information System (INIS)

    Chen, Changqi; Tang, Hongjun; Qi, Songsong; Cheng, Yong; Feng, Hansheng; Peng, Xuebing; Song, Yuntao

    2014-01-01

    Highlights: • We discussed the conceptual design of CFETR blanket RH maintenance system. • The mathematical model of electro-hydraulic servo system was calculated. • A fuzzy adaptive PD controller was designed based on control theory and experience. • The co-simulation models of the system were established with AMESim/Simulink. • The fuzzy adaptive PD algorithm was designed as the core strategy of the system. - Abstract: Based on the technical design requirements of China Fusion Engineering Test Reactor (CFETR) blanket remote handling (RH) maintenance, this paper focus on the control method of achieving high synchronization accuracy of electro-hydraulic servo system. Based on fuzzy control theory and practical experience, a fuzzy adaptive proportional-derivative (PD) controller was designed. Then a more precise co-simulation model was established with AMESim/Simulink. Through the analysis of simulation results, a fuzzy adaptive PD control algorithm was designed as the core strategy of electro-hydraulic servo control system

  16. Instrumentation maintenance

    International Nuclear Information System (INIS)

    Mack, D.A.

    1976-09-01

    It is essential to any research activity that accurate and efficient measurements be made for the experimental parameters under consideration for each individual experiment or test. Satisfactory measurements in turn depend upon having the necessary instruments and the capability of ensuring that they are performing within their intended specifications. This latter requirement can only be achieved by providing an adequate maintenance facility, staffed with personnel competent to understand the problems associated with instrument adjustment and repair. The Instrument Repair Shop at the Lawrence Berkeley Laboratory is designed to achieve this end. The organization, staffing and operation of this system is discussed. Maintenance policy should be based on studies of (1) preventive vs. catastrophic maintenance, (2) records indicating when equipment should be replaced rather than repaired and (3) priorities established to indicate the order in which equipment should be repaired. Upon establishing a workable maintenance policy, the staff should be instructed so that they may provide appropriate scheduled preventive maintenance, calibration and corrective procedures, and emergency repairs. The education, training and experience of the maintenance staff is discussed along with the organization for an efficient operation. The layout of the various repair shops is described in the light of laboratory space and financial constraints

  17. A thermodynamic description of the system Pd-Rh-H-D-T

    Energy Technology Data Exchange (ETDEWEB)

    Joubert, J.-M., E-mail: jean-marc.joubert@icmpe.cnrs.fr [Chimie Metallurgique des Terres Rares, Institut de Chimie et des Materiaux Paris-Est, CNRS, Universite Paris-Est, UMR 7182, 2-8 Rue Henri Dunant, F-94320 Thiais (France); Thiebaut, S. [CEA/DAM/Valduc, F-21120 Is sur Tille (France)

    2011-02-15

    The quinary system D-H-Pd-Rh-T has been described thermodynamically by the CALPHAD approach. Previous descriptions of the binary subsystems have been used. To model the high pressure data an equation of state for the gases D{sub 2} and T{sub 2} compatible with the CALPHAD approach has been obtained similar to that previously used for H{sub 2}. A complete literature search has been undertaken for the three ternary systems H-Pd-Rh, D-Pd-Rh and Pd-Rh-T and the most significant experimental data have been selected for a thermodynamic assessment of these systems. In order to complement the available data, pressure-composition curves have been measured at different temperatures for the two last systems in the present work. Calculations and optimization of the system under para-equilibrium conditions, i.e. in pseudo-binary systems (Pd,Rh)-H, (Pd,Rh)-D or (Pd,Rh)-T, have been achieved using a pseudo-atom describing the Pd-Rh solid solution. This special method allows the presence of a miscibility gap in the binary metallic system to be dealt with. We show that a simple combination of the binary systems alone is unable to properly describe these ternary systems and that ternary interaction parameters have to be introduced. The binary and ternary systems may then be combined to perform calculations in the quinary D-H-Pd-Rh-T system. It is believed that extrapolation in systems containing different isotopes are fairly accurate provided that the so-called Toop model is used.

  18. Analysis of the ITER ECH Upper Port Launcher remote maintenance using virtual reality

    International Nuclear Information System (INIS)

    Elzendoorn, Ben; de Baar, Marco; Chavan, Rene; Goodman, Timothy; Heemskerk, Cock; Heidinger, Roland; Kleefeldt, Klaus; Koning, Jarich; Sanders, Stephen; Spaeh, Peter; Strauss, Dirk; Verhoeven, Toon; Vreede, Fred de

    2009-01-01

    All ITER sub-systems of remote handling (RH) classes 1 and 2 have to be remotely maintainable. The maintenance strategy for these components has to ensure system availability after failure or scheduled maintenance. This paper shows how virtual reality (VR) simulation can be used as a tool to analyze the maintenance process, to predict the mean time to repair and to ensure the RH compatibility of one ITER sub-system, the Upper Port Launcher (UPL) . Special emphasis is put on the development of RH procedures and the identification of tooling requirements. The possibility to simulate RH logistics and repair actions in an early stage of the design process allows for the identification of those maintenance actions that require dedicated tests in the Launcher Handling Test Facility at Karlsruhe. The VR analysis, together with dedicated mock-up tests will demonstrate the RH compatibility of the UPL plug, provide input to the design of the Port Plug maintenance area in the ITER Hot Cell, and support the development of RH maintenance tooling.

  19. Maintenance Process Strategic Analysis

    Science.gov (United States)

    Jasiulewicz-Kaczmarek, M.; Stachowiak, A.

    2016-08-01

    The performance and competitiveness of manufacturing companies is dependent on the availability, reliability and productivity of their production facilities. Low productivity, downtime, and poor machine performance is often linked to inadequate plant maintenance, which in turn can lead to reduced production levels, increasing costs, lost market opportunities, and lower profits. These pressures have given firms worldwide the motivation to explore and embrace proactive maintenance strategies over the traditional reactive firefighting methods. The traditional view of maintenance has shifted into one of an overall view that encompasses Overall Equipment Efficiency, Stakeholders Management and Life Cycle assessment. From practical point of view it requires changes in approach to maintenance represented by managers and changes in actions performed within maintenance area. Managers have to understand that maintenance is not only about repairs and conservations of machines and devices, but also actions striving for more efficient resources management and care for safety and health of employees. The purpose of the work is to present strategic analysis based on SWOT analysis to identify the opportunities and strengths of maintenance process, to benefit from them as much as possible, as well as to identify weaknesses and threats, so that they could be eliminated or minimized.

  20. Maintenance Plan for the Performance Assessments and Composite Analyses for the Area 3 and Area 5 Radioactive Waste Management Sites at the Nevada Test Site

    International Nuclear Information System (INIS)

    V. Yucel

    2002-01-01

    U.S. Department of Energy (DOE) Order 435.1 requires that performance assessments (PAs) and composite analyses (CAs) for low-level waste (LLW) disposal facilities be maintained by the field offices. This plan describes the activities to be performed in maintaining the Performance Assessment (PA) and Composite Analysis (CA) for the Area 3 and Area 5 Radioactive Waste Management Sites (RWMSs) at the Nevada Test Site (NTS). The Disposal Authorization Statement (DAS) for the continuing operations of a LLW facility at the DOE complex specifies the conditions for operations based on approval of a PA and CA, and requires the facility to implement a maintenance program to assure that these conditions will remain protective of the public health and the environment in the future. The goal of the maintenance program is to provide that assurance. The maintenance process is an iterative one in which changing conditions may result in a revision of PA and CA; the revised PA and CA may impose a different set of conditions for facility operation, closure, and postclosure. The maintenance process includes managing uncertainty, performing annual reviews, submitting annual summary reports to DOE Headquarters (DOE/HQ), carrying out special analyses, and revising the PAs and CAs, if necessary. Management of uncertainty is an essential component of the maintenance program because results of the original PAs and CAs are understood to be based on uncertain assumptions about the conceptual models; the mathematical models and parameters; and the future state of the lands, disposal facilities, and human activities. The annual reviews for the PAs include consideration of waste receipts, facility specific factors, results of monitoring, and results of research and development (R and D) activities. Likewise, results of ongoing R and D, changes in land-use planning, new information on known sources of residual radioactive materials, and identification of new sources may warrant an evaluation to

  1. An analysis of the radiation field characteristics for extremity dose assessment during maintenance periods at nuclear power plants in Korea

    International Nuclear Information System (INIS)

    Kim, H. G.; Kong, T. Y.

    2012-01-01

    Workers who maintain the water chambers of steam generators during maintenance periods in nuclear power plants (NPPs) have a higher likelihood of high radiation exposure, even if they are exposed for a short period of time. In particular, it is expected that the hands of workers would receive the highest radiation exposure as a consequence of hand contact with radioactive materials. In this study, a characteristic analysis of inhomogeneous radiation fields for contact operations was conducted using thermoluminescent dosemeters for the whole body and extremities during maintenance periods at Korean NPPs. It was observed that inhomogeneous radiation fields for contact operations at NPPs were dominated by high-energy photons. (authors)

  2. Hypersensitivity reaction with intravenous GnRH after pulsatile subcutaneous GnRH treatment in male hypogonadotrophic hypogonadism.

    OpenAIRE

    Popović, V.; Milosević, Z.; Djukanović, R.; Micić, D.; Nesović, M.; Manojlović, D.; Djordjević, P.; Mićić, J.

    1988-01-01

    Chronic pulsatile subcutaneous administration of low doses of gonadotrophin releasing hormone (GnRH) is an effective therapy for men with hypogonadotrophic hypogonadism. Hypersensitivity reactions to GnRH are rare. We wish to report hypersensitivity reactions with intravenous GnRH after low dose subcutaneous pulsatile GnRH treatment in two men with hypogonadotrophic hypogonadism due to suprasellar disease.

  3. Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes

    International Nuclear Information System (INIS)

    Saboori, A.M.; Smith, B.L.; Agre, P.

    1988-01-01

    A M r 32,000 integral membrane protein has previously been identified on erythrocytes bearing the Rh(D) antigen and is thought to contain the antigenic variations responsible for the different Rh phenotypes. To study it on a biochemical level, a simple large-scale method was developed to purify the M r 32,000 Rh protein from multiple units of Rh(D)-positive and -negative blood. Erythrocyte membrane vesicles were solubilized in NaDodSO 4 , and a tracer of immunoprecipitated 125 I surface-labeled Rh protein was added. The Rh protein was purified to homogeneity by hydroxylapatite chromatography followed by preparative NaDodSO 4 /PAGE. Approximately 25 nmol of pure Rh protein was recovered from each unit of Rh(D)-positive and -negative blood. Rh protein purified from both Rh phenotypes appeared similar by one-dimensional NaDodSO 4 /PAGE, and the N-terminal amino acid sequences for the first 20 residues were identical. Rh proteins purified from Rh(D)-positive and -negative blood were compared by two-dimensional iodopeptide mapping after 125 I-labeling and α-chymotrypsin digestion. The peptide maps were very similar. These data indicate that a similar core Rh protein exists in both Rh(D)-positive and -negative erythrocytes, and the Rh proteins from erythrocytes with different Rh phenotypes contain distinct structural polymorphisms

  4. Integrated maintenance program (IMP)

    International Nuclear Information System (INIS)

    Zemdegs, R.T.; Chout, Q.B.

    1998-01-01

    Approaches to the maintenance of nuclear power plants have undergone significant change in the past several decades. The traditional breakdown approach has been displaced by preventive (calendar-based) maintenance and more recently, by condition-based maintenance (CBM). This is largely driven by the fact that traditional maintenance programs, derived primarily from equipment vendor recommendations, are generally unsuccessful in controlling maintenance costs or equipment failures. Many advances in the maintenance field have taken place since the maintenance plans for Ontario Hydro's nuclear plants were initially established. Ontario Hydro nuclear plant operating costs can be substantially reduced and Incapability Factor improved with the application of modern maintenance processes and tools. Pickering is designated as the lead station for IMP. Of immediate concern is the fact that Pickering Nuclear Division has been experiencing a significant backlog of Operating Preventive Maintenance Callups. This backlog, over 2000, is unacceptable to both station management and the nuclear regulator, the Atomic Energy Control Board. In addition there are over 500 callups in various stages of revision (in hyperspace) without an adequate control nor reporting system to manage their completion. There is also considerable confusion about the classification of l icensing c allups, e.g. callups which are mandatory as a result of legal requirements. Furthermore the ineffectiveness of the Preventive Maintenance (PM) has been the subject of peer audits and Atomic Energy Control Board (AECB) findings over the past several years. The current preventive maintenance ratio PM2 /(PM+CM3) at Pickering ND is less than 20%, due to the current high load of equipment breakdown. This past summer, an Independent Integrated Performance Assessment (IIPA) review at Ontario Hydro confirmed these concerns. Over the past several years, Ontario Hydro nuclear staff have evaluated several programs to improve

  5. Maintenance Action Readiness Assessment Plan for Waste Area Grouping 1 inactive Tanks 3001-B, 3004-B, T-30, and 3013 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    1995-07-01

    This Readiness Assessment Plan has been prepared to document operational readiness for the maintenance action consisting of remediation of four inactive liquid low-level radioactive tanks in Waste Area Grouping 1 at Oak Ridge National Laboratory. The four tanks to be remediated are Tanks 3001-B, 3004-B, T-30, and 3013. Tanks 3001-B, 3004-B, and T-30 will be removed from the ground. Because of logistical issues associated with excavation and site access, Tank 3013 will be grouted in place and permanently closed. This project is being performed as a maintenance action rather than an action under the Comprehensive Environmental Response, Compensation, and Liability Act, because the risk to human health and environment is well below the US Environmental Protection Agency's level of concern. The decision to proceed as a maintenance action was documented by an interim action proposed plan, which is included in the administrative record. A Readiness Assessment Team has been assembled to review the criteria deemed necessary to conduct the remediation tasks. These criteria include approval of all plans, acquisition of needed equipment, completion of personnel training, and coordination with plant health and safety personnel. Once the criteria have been met and documented, the task will begin. The readiness assessment is expected to be completed by late July 1995, and the task will begin thereafter

  6. Evaluation of GnRH analogue testing in diagnosis and management of children with pubertal disorders

    Directory of Open Access Journals (Sweden)

    Hemchand K Prasad

    2012-01-01

    Full Text Available Context: Gonadotrophin releasing hormone (GnRH stimulation test is pivotal in the assessment of children with pubertal disorders. However, lack of availability and high cost often result in the test falling into disfavor. We routinely use the GnRH analogue stimulation test as an alternative at our center. Aim: To present the data on children with endocrine disorders who underwent GnRH agonist stimulation test in pediatric endocrine clinic of a tertiary care referral hospital. Setting and Design: Pediatric endocrine clinic of a tertiary care referral hospital. Retrospective analysis of case records. Materials and Methods: The details pertaining to clinical and radiological parameters and hormonal tests were retrieved from case records of 15 children who underwent GnRH agonist stimulation test from May 2010 to April 2011. Results: Indications for testing with GnRH analogue were evaluation of delayed puberty, diagnosis of precocious puberty, assessment of hormonal suppression in treatment of precocious puberty and micropenis in two, nine, three and one cases, respectively. The results of the test and clinical and radiological parameters were in concordance. The test was also crucial in diagnosing the onset of central precocious puberty in two children with congenital adrenal hyperplasia. Conclusion: GnRH agonist test is a convenient, safe test that can be performed on an out-patient basis and can help the clinicians in the correct diagnosis and appropriate treatment of various puberty-related disorders.

  7. Non-invasive assessment of the reproductive cycle in free-ranging female African elephants (Loxodonta africana) treated with a gonadotropin-releasing hormone (GnRH) vaccine for inducing anoestrus.

    Science.gov (United States)

    Benavides Valades, Gabriela; Ganswindt, Andre; Annandale, Henry; Schulman, Martin L; Bertschinger, Henk J

    2012-08-25

    In southern Africa, various options to manage elephant populations are being considered. Immunocontraception is considered to be the most ethically acceptable and logistically feasible method for control of smaller and confined populations. In this regard, the use of gonadotropin-releasing hormone (GnRH) vaccine has not been investigated in female elephants, although it has been reported to be safe and effective in several domestic and wildlife species. The aims of this study were to monitor the oestrous cycles of free-ranging African elephant cows using faecal progestagen metabolites and to evaluate the efficacy of a GnRH vaccine to induce anoestrus in treated cows. Between May 2009-June 2010, luteal activity of 12 elephant cows was monitored non-invasively using an enzyme immunoassay detecting faecal 5alpha-reduced pregnanes (faecal progestagen metabolites, FPM) on a private game reserve in South Africa. No bulls of breeding age were present on the reserve prior to and for the duration of the study. After a 3-month control period, 8 randomly-selected females were treated twice with 600 micrograms of GnRH vaccine (Improvac®, Pfizer Animal Health, Sandton, South Africa) 5-7 weeks apart. Four of these females had been treated previously with the porcine zona pellucida (pZP) vaccine for four years (2004-2007). All 12 monitored females (8 treated and 4 controls) showed signs of luteal activity as evidenced by FPM concentrations exceeding individual baseline values more than once. A total of 16 oestrous cycles could be identified in 8 cows with four of these within the 13 to 17 weeks range previously reported for captive African elephants. According to the FPM concentrations the GnRH vaccine was unable to induce anoestrus in the treated cows. Overall FPM levels in samples collected during the wet season (mean 4.03 micrograms/gram dry faeces) were significantly higher (Pelephants. These results indicate that irregular oestrous cycles occur amongst free

  8. 25 CFR 171.500 - How does BIA determine the annual operation and maintenance assessment rate for the irrigation...

    Science.gov (United States)

    2010-04-01

    ... costs needed for the reliable operation of the irrigation facility infrastructure; (8) Maintenance of a... 25 Indians 1 2010-04-01 2010-04-01 false How does BIA determine the annual operation and... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND...

  9. Preparation and Thermoelectric Characteristics of ITO/PtRh:PtRh Thin Film Thermocouple.

    Science.gov (United States)

    Zhao, Xiaohui; Wang, Hongmin; Zhao, Zixiang; Zhang, Wanli; Jiang, Hongchuan

    2017-12-15

    Thin film thermocouples (TFTCs) can provide more precise in situ temperature measurement for aerospace propulsion systems without disturbance of gas flow and surface temperature distribution of the hot components. ITO/PtRh:PtRh TFTC with multilayer structure was deposited on alumina ceramic substrate by magnetron sputtering. After annealing, the TFTC was statically calibrated for multiple cycles with temperature up to 1000 °C. The TFTC with excellent stability and repeatability was realized for the negligible variation of EMF in different calibration cycles. It is believed that owing to oxygen diffusion barriers by the oxidation of top PtRh layer and Schottky barriers formed at the grain boundaries of ITO, the variation of the carrier concentration of ITO film is minimized. Meanwhile, the life time of TFTC is more than 30 h in harsh environment. This makes ITO/PtRh:PtRh TFTC a promising candidate for precise surface temperature measurement of hot components of aeroengines.

  10. XANES and XMCD studies of FeRh and CoRh nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Smekhova, A; Wilhelm, F; Rogalev, A [European Synchrotron Radiation Facility, Grenoble Cedex 9, 38043 (France); Atamena, N; Ciuculescu, D; Amiens, C [Laboratoire de Chimie de Coordination, UPR 8241-CNRS, Toulouse Cedex 04, 31077 (France); Lecante, P, E-mail: smeal@esrf.f [Centre d' Elaboration de Materiaux et d' Etudes Structurales, UPR 8011-CNRS, Toulouse Cedex 04, 31055 (France)

    2010-01-01

    Element-selective magnetic properties of new core-shell bimetallic MRh (M=Fe or Co) nanoparticles (NP{sub S}) of 50/50 composition with either M-Rh or Rh-M core/shell order and an average diameter of {approx}2 nm have been investigated by X-ray Absorption Spectroscopy (XANES) and X-Ray Magnetic Circular Dichroism (XMCD) technique. XANES spectra at the Rh L{sub 2,3} edges exhibit the same characteristic features for all systems having the Rh metal enriched shell. XMCD experiments at the same edges have shown that 4d states of Rh atoms acquire a magnetic moment as a result of hybridization with iron or cobalt 3d states. As expected the value of this induced moment depends on the 3d transition metal and on the core/shell chemical order in the nanoparticle.

  11. Melatonin Inhibits GnRH-1, GnRH-3 and GnRH Receptor Expression in the Brain of the European Sea Bass, Dicentrarchus labrax

    Directory of Open Access Journals (Sweden)

    José Antonio Muñoz-Cueto

    2013-04-01

    Full Text Available Several evidences supported the existence of melatonin effects on reproductive system in fish. In order to investigate whether melatonin is involved in the modulation of GnRH systems in the European sea bass, we have injected melatonin (0.5 µg/g body mass in male specimens. The brain mRNA transcript levels of the three GnRH forms and the five GnRH receptors present in this species were determined by real time quantitative PCR. Our findings revealed day–night variations in the brain expression of GnRH-1, GnRH-3 and several GnRH receptors (dlGnRHR-II-1c, -2a, which exhibited higher transcript levels at mid-light compared to mid-dark phase of the photocycle. Moreover, an inhibitory effect of melatonin on the nocturnal expression of GnRH-1, GnRH-3, and GnRH receptors subtypes 1c, 2a and 2b was also demonstrated. Interestingly, the inhibitory effect of melatonin affected the expression of hypophysiotrophic GnRH forms and GnRH receptors that exhibit day–night fluctuations, suggesting that exogenous melatonin reinforce physiological mechanisms already established. These interactions between melatoninergic and GnRH systems could be mediating photoperiod effects on reproductive and other rhythmic physiological events in the European sea bass.

  12. Study to determine the reliability and validity of a needs-assessment instrument used within the mechanical maintenance field of the nuclear electrical-generating industry

    International Nuclear Information System (INIS)

    Russell, L.O.

    1982-01-01

    This study was to determine if task parameter ratings provided by nuclear power plant maintenance mechanics assessed the true task frequency, criticality, and difficulty. This was to measure the data's usefulness as a training needs assessment indicator. A questionnaire entitled Job Task Questionnaire for Maintenance Mechanics was developed and used to collect data from job incumbents. Development was based on plant visits and incumbent interviews. Duties, tasks, parameters, and scales were then compiled to form the questionnaire. The questionnaire was then pilot tested. A random sample was selected from the national population of nuclear power plant maintenance mechanics. This resulted in a sample which was stratified across the job title and random within the job title. The descriptive analysis did not tend to indicate that the mean value of each task parameter provided a true or valid value. The overall conclusion drawn from the data analysis was that the ratings did not provide a substantially valid or reliable indication on which to base task training needs

  13. N-of-1 study of weight loss maintenance assessing predictors of physical activity, adherence to weight loss plan and weight change.

    Science.gov (United States)

    Kwasnicka, Dominika; Dombrowski, Stephan U; White, Martin; Sniehotta, Falko F

    2017-06-01

    Behaviour change interventions are effective in supporting individuals to achieve clinically significant weight loss, but weight loss maintenance (WLM) is less often attained. This study examined predictive variables associated with WLM. N-of-1 study with daily ecological momentary assessment combined with objective measurement of weight and physical activity, collected with wireless devices (Fitbit™) for six months. Eight previously obese adults who had lost over 5% of their body weight in the past year took part. Data were analysed using time series methods. Predictor variables were based on five theoretical themes: maintenance motives, self-regulation, personal resources, habits, and environmental influences. Dependent variables were: objectively estimated step count and weight, and self-reported WLM plan adherence. For all participants, daily fluctuations in self-reported adherence to their WLM plan were significantly associated with most of the explanatory variables, including maintenance motivation and satisfaction with outcomes, self-regulation, habit, and stable environment. Personal resources were not a consistent predictor of plan adherence. This is the first study to assess theoretical predictions of WLM within individuals. WLM is a dynamic process including the interplay of motivation, self-regulation, habit, resources, and perceptions of environmental context. Individuals maintaining their weight have unique psychological profiles which could be accounted for in interventions.

  14. CORRELATION BETWEEN ANTHROPOMETRY, BIOCHEMICAL MARKERS AND SUBJECTIVE GLOBAL ASSESSMENT – DIALYSIS MALNUTRITION SCORE AS PREDICTORS OF NUTRITIONAL STATUS OF THE MAINTENANCE HEMODIALYSIS PATIENTS

    Directory of Open Access Journals (Sweden)

    Vanitha Rani N, S. Kavimani, Soundararajan P, Chamundeeswari D, Kannan Gopal

    2015-10-01

    Full Text Available Background: Protein energy malnutrition is the major cause of poor prognostic outcome in patients on maintenance hemodialysis (MHD. The assessment of nutritional status in patients on maintenance hemodialysis should be done both subjectively and objectively by integrating clinical, biochemical and anthropometric measurements. A study was conducted to assess the possible correlations between the subjective global assessment-dialysis malnutrition score (SGA-DMS, anthropometric measurements, and biochemical parameters in hemodialysis patients. Methods: The study included 90 patients (55 males and 35 females; age range of 25 to 73 years; mean age 52.62 ± 11.7 years undergoing twice/thrice weekly maintenance hemodialysis for six months and above in the dialysis unit of a tertiary care teaching hospital. The MHD patients were assessed by SGA -DMS, anthropometry and biochemical indicators (serum albumin, iron, ferritin and transferrin of nutritional status. Results: According to the SGA-DMS 54.4 % were moderate to severely malnourished, 31% were mild to moderately nourished and 14.4% were well nourished. There was a highly significant negative correlation between SGA –DMS and serum albumin, iron, transferrin; positive correlation between SGA-DMS and ferritin (P<0.0001. Body mass index, upper arm circumferences, and skin fold thickness had a highly significant negative correlation with SGA-DMS (P<0.001, where as the lean body mass, total body water and the fat free mass had a significant negative correlation (P<0.05. Conclusion: SGA-DMS correlated with anthropometric and biochemical parameters that are indicative of nutritional status. SGA –DMS used in conjunction with other objective nutritional assessment methods may be of greater impact in determining nutritional status of hemodialysis patients.

  15. Absolute calibration of the Rh-103 (n, n') Rh-103m reaction rate

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, W.H.; Murphy, M.F.; March, M.R. [Reactor Physics Division, Atomic Energy Establishment, Winfrith, Dorchester, Dorset (United Kingdom)

    1979-05-15

    The uncertainties in determining the absolute values of the Rh-103 (n, n') Rh-103m reaction rate (which is widely used as a neutron damage flux monitor) have been reduced to {approx}{+-}5%. This has been achieved with the use of a calibrated source of Pd-103-Rh-103m activity supplied by the I.A.E.A. Agreement to within 3% between measured and calculated values of the reaction rate (normalised to the U-238 fission rate) has been achieved. (author)

  16. Improvement of castable refractories for RH snorkel; RH shinshitsukanyo futeikeizai no kaizen

    Energy Technology Data Exchange (ETDEWEB)

    Nishi, K.; Obana, T.; Fijii, T.; Shimizu, I. [Harima Ceramics Corp., Hyogo (Japan)

    1999-11-01

    Relating to corrosion of RH submerged nozzle, resistance against iron oxide of monolithic refractories was examined. Corrosion and seepage of refractories were measured by rotating corrosion, refractories include alumina-spinel castable, which is applied to RH under tank, and alumina-magnesia castable, which is generally used for RH, submerged nozzle. Alumina-spinel castable is superior in resistance against iron oxide than alumina-magnesia castable, and the resistance decreased with increase of stainless fiber addition to castable. Alumina-spinel castable without stainless fiber was suitable for bottom end of the dipping pipe. (NEDO)

  17. Absolute calibration of the Rh-103 (n, n') Rh-103m reaction rate

    International Nuclear Information System (INIS)

    Taylor, W.H.; Murphy, M.F.; March, M.R.

    1979-05-01

    The uncertainties in determining the absolute values of the Rh-103 (n, n') Rh-103m reaction rate (which is widely used as a neutron damage flux monitor) have been reduced to ∼±5%. This has been achieved with the use of a calibrated source of Pd-103-Rh-103m activity supplied by the I.A.E.A. Agreement to within 3% between measured and calculated values of the reaction rate (normalised to the U-238 fission rate) has been achieved. (author)

  18. Noninvasive fetal RhD genotyping

    DEFF Research Database (Denmark)

    Clausen, Frederik Banch; Damkjær, Merete Berthu; Dziegiel, Morten Hanefeld

    2014-01-01

    Immunization against RhD is the major cause of hemolytic disease of the fetus and newborn (HDFN), which causes fetal or neonatal death. The introduction of postnatal immune prophylaxis in the 1960s drastically reduced immunization incidents in pregnant, D-negative women. In several countries, ant...

  19. Preparation of a 102Rh tracer

    International Nuclear Information System (INIS)

    Gorski, B.; Heinig, W.

    1986-01-01

    Electronic emission detectors used in reactors for the control of the neutron flux density contain rhodium as an emitter material. By dissolving the emitter material in a mixture of hydrobromic acid and bromine it is possible to get 102 Rh labelled solutions of the spent detectors. The preparation and purification of the solutions are described. (author)

  20. Atomic and molecular adsorption on Rh(111)

    DEFF Research Database (Denmark)

    Mavrikakis, Manos; Rempel, J.; Greeley, Jeffrey Philip

    2002-01-01

    A systematic study of the chemisorption of both atomic (H, O, N, S, C), molecular (N-2, CO, NO), and radical (CH3, OH) species on Rh(111) has been performed. Self-consistent, periodic, density functional theory (DFT-GGA) calculations, using both PW91 and RPBE functionals, have been employed to de...

  1. Radioprotective effects of Sipunculus nudus L. polysaccharide combined with WR-2721, rhIL-11 and rhG-CSF on radiation-injured mice

    International Nuclear Information System (INIS)

    Jiang Shuqi; Shen Xianrong; Liu Yuming; He Ying; Jiang Dingwen; Chen Wei

    2015-01-01

    This study investigated the radioprotective effect of Sipunculus nudus L. polysaccharide (SNP) in combination with WR-2721, rhIL-11 and rhG-CSF on irradiated mice. A total of 70 Imprinting Control Region (ICR) mice were divided into seven groups: the control group, the model group and five administration groups. All groups, except the control group, were exposed to a 5 Gy 60 Co γ-ray beam. Blood parameters [including white blood cell (WBC), red blood cell (RBC) and platelet counts and hemoglobin level] were assessed three days before irradiation, and the on the 3rd, 7th and 14th days after irradiation. Spleen, thymus and testicular indices, DNA contents of bone marrow cells, bone marrow nucleated cells, sperm counts, superoxide dismutase (SOD), malondialdehyde (MDA), testosterone and estradiol levels in the serum were assessed on the 14th day after irradiation. The combined administration of SNP, WR-2721, rhIL-11 and rhG-CSF exerted synergistic recovery effects on peripheral blood WBC, RBC and platelet counts and hemoglobin levels in irradiated mice, and synergistic promotion effects on spleen, thymus, testicle, bone marrow nucleated cells and sperm counts in irradiated mice. The synergistic administration increased the serum SOD activities and serum testosterone content of irradiated mice, but synergy decreased the content of serum MDA and estradiol in irradiated mice. These results suggest that the combined administration of SNP, WR-2721, rhIL-11 and rhG-CSF should increase the efficacy of these drugs for acute radiation sickness, protect immunity, hematopoiesis and the reproductive organs of irradiated-damaged mice, and improve oxidation resistance in the body. (author)

  2. {sup 103}Rh NMR investigation of the superconductor Rh{sub 17}S{sub 15}

    Energy Technology Data Exchange (ETDEWEB)

    Koyama, T., E-mail: t-koyama@sci.u-hyogo.ac.j [Graduate School of Material Science, University of Hyogo, Kamigori, Hyogo 678-1297 (Japan); Kanda, K.; Motoyama, G.; Ueda, K.; Mito, T.; Kohara, T. [Graduate School of Material Science, University of Hyogo, Kamigori, Hyogo 678-1297 (Japan); Nakamura, H. [Department of Materials Science and Engineering, Kyoto University, Kyoto 606-8501 (Japan)

    2010-12-15

    We present {sup 103}Rh NMR studies for the superconductor Rh{sub 17}S{sub 15} (T{sub c} 5.4 K). We have identified the observed NMR lines corresponding to four different Rh sites in the cubic unit cell and deduced the temperature (T) dependence of the Knight shift components in Rh 24m site whose point symmetry is not axial. The isotropic part of the Knight shift K decreases with T in the normal state, indicating the negative hyperfine coupling and the enhancement of the spin susceptibility at lower T. The sudden change of K below T{sub c} is an indication of the spin-singlet Cooper paring.

  3. Verifying elementary ITER maintenance actions with the MS2 benchmark product

    NARCIS (Netherlands)

    Heemskerk, C. J. M.; Elzendoorn, B. S. Q.; Magielsen, A. J.; Schropp, G. Y. R.

    2011-01-01

    A new facility has been taken in operation to investigate the influence of visual and haptic feedback on the performance of remotely executed ITER RH maintenance tasks. A reference set of representative ITER remote handling maintenance tasks was included the master slave manipulator system (MS2)

  4. Analysis of the ITER ECH Upper Port Launcher remote maintenance using virtual reality

    NARCIS (Netherlands)

    Elzendoorn, B.; Baar, M. de; Chavan, R.; Goodman, T.; Heemskerk, C.; Heidinger, R.; Kleefeldt, K.; Koning, J.; Sanders, S.; Späh, P.; Strauss, D.; Verhoeven, T.; Vreede, F. de

    2009-01-01

    All ITER sub-systems of remote handling (RH) classes 1 and 2 have to be remotely maintainable. The maintenance strategy for these components has to ensure system availability after failure or scheduled maintenance. This paper shows how virtual reality (VR) simulation [1] can be used as a tool to

  5. Remarks on the 103Rh(n,n') sup(103m)Rh excitation curve

    International Nuclear Information System (INIS)

    Pazsit, A.; Peto, G.; Csikai, J.; Jozsa, I.; Bacso, J.

    1975-01-01

    The cross sections of the 103 Rh(n,n')sup(103m)Rh reaction have been measured at 2.7MeV and 14.8MeV neutron energies as well as for neutron spectra of 252 Cf and 239 Pu-α-Be sources; the results are 999+-111mb, 216+-26mb, 757+-53mb and 918+-64mb, respectively. (author)

  6. The Association between ABO and Rh Blood Groups and Risk of Endometriosis in Iranian Women.

    Science.gov (United States)

    Malekzadeh, Farideh; Moini, Ashraf; Amirchaghmaghi, Elham; Daliri, Leila; Akhoond, Mohammad Reza; Talebi, Mehrak; Hosseini, Rihaneh

    2018-06-01

    Endometriosis is a common gynaecological disease that affects quality of life for women. Several studies have revealed that both environmental and genetic factors contribute to the development of endometriosis. The aim of this study was to investigate the distribution of ABO and Rh blood groups in Iranian women with endometriosis who presented to two referral infertility centers in Tehran, Iran. In this case-control study, women who referred to Royan Institute and Arash Women's Hospital for diagnostic laparoscopy between 2013 and 2014 were assessed. Based on the laparoscopy findings, we categorized the women into two groups: endometriosis and control (women without endometriosis and normal pelvis). Chi-square and logistic regression tests were used for data analysis. In this study, we assessed 433 women, of which 213 patients were assigned to the endometriosis group while the remaining 220 subjects comprised the control group. The most frequent ABO blood group was O (40.6%). The least frequent blood group was AB (4.8%). In terms of Rh blood group, Rh+ (90.1%) was more frequent than Rh- (9.9%). There was no significant correlation between ABO (P=0.091) and Rh (P=0.55) blood groups and risk of endometriosis. Also, there was no significant difference between the two groups with regards to the stage of endometriosis and distribution of ABO and Rh blood groups (P>0.05). Although the O blood group was less dominant in Iranian women with endometriosis, we observed no significant correlation between the risk of endometriosis and the ABO and Rh blood groups. Endometriosis severity was not correlated to any of these blood groups. Copyright© by Royan Institute. All rights reserved.

  7. Origin of room temperature ferromagnetic moment in Rh-rich [Rh/Fe] multilayer thin films

    International Nuclear Information System (INIS)

    Kande, Dhishan; Laughlin, David; Zhu Jiangang

    2010-01-01

    B2 ordered FeRh thin films switch from antiferromagnetic (AFM) to ferromagnetic (FM) state on heating above 350 K and switch back on cooling, with a hysteresis. This property makes FeRh a very attractive choice as a write-assist layer material for low temperature heat assisted magnetic recording (HAMR) media. Studies have shown that as we decrease the thickness of the FeRh films, the B2 phase is no longer AFM even below 350 K and there is a thickness dependant FM stabilization of the B2 phase. It was also proved that slightly Rh-richer compositions (>50 at. % Rh) were more preferable to stabilize the AFM phase. The current study focuses on growing highly ordered FeRh films by alternate layer rf sputtering of thin layers of iron and rhodium onto a heated substrate. It has been shown that films with rhodium content beyond 55 at. % contain a disordered bcc FM phase which gives rise to residual moment at room temperature even for thicker films.

  8. A cross-sectional assessment of biomarker levels around implants versus natural teeth in periodontal maintenance patients.

    Science.gov (United States)

    Recker, Erica N; Avila-Ortiz, Gustavo; Fischer, Carol L; Pagan-Rivera, Keyla; Brogden, Kim A; Dawson, Deborah V; Elangovan, Satheesh

    2015-02-01

    Recent studies point to the clinical utility of using peri-implant sulcular fluid (PISF) as a valuable diagnostic aid for monitoring peri-implant tissue health. The objectives of this study are to determine the levels of key biomarkers in PISF in periodontal maintenance participants and compare them with their corresponding levels in gingival crevicular fluid (GCF) obtained from the same participants. PISF and GCF were collected from an implant and a contralateral natural tooth after the clinical examination of 73 participants. The levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12, IL-17A, tumor necrosis factor (TNF)-α, C-reactive protein, osteoprotegerin, leptin, and adiponectin were determined using multiplex proteomic immunoassays. The correlation of biomarker concentrations between GCF versus PISF, within GCF or PISF, and with several covariates (age, brushing frequency, days since professional cleaning, probing depth [PD], and plaque index) were also determined. Significantly higher levels of IL-17A (P = 0.02) and TNF-α (P = 0.03) were noted in PISF when compared with their levels in GCF. Significant positive correlations were noted between the concentrations of cytokines in PISF versus their levels in GCF. Among the covariates, a significant positive correlation was noted between mean PDs around implants and levels of IL-1β (P periodontal maintenance patients, which is critical information before establishing PISF as a diagnostic fluid to monitor peri-implant health.

  9. Opportune maintenance and predictive maintenance decision support

    OpenAIRE

    Thomas , Edouard; Levrat , Eric; Iung , Benoît; Cocheteux , Pierre

    2009-01-01

    International audience; Conventional maintenance strategies on a single component are being phased out in favour of more predictive maintenance actions. These new kinds of actions are performed in order to control the global performances of the whole industrial system. They are anticipative in nature, which allows a maintenance expert to consider non-already-planned maintenance actions. Two questions naturally emerge: when to perform a predictive maintenance action; how a maintenance expert c...

  10. CANDU plant maintenance: Recent developments

    International Nuclear Information System (INIS)

    Charlebois, P.

    2000-01-01

    CANDU units have long been recognized for their exceptional safety and reliability. Continuing development in the maintenance area has played a key role in achieving this performance level. For over two decades, safety system availability has been monitored closely and system maintenance programs adjusted accordingly to maintain high levels of performance. But as the plants approach mid life in a more competitive environment and component aging becomes a concern, new methods and techniques are necessary. As a result, recent developments are moving the maintenance program largely from a corrective and preventive approach to predictive and condition based maintenance. The application of these techniques is also being extended to safety related systems. These recent developments include use of reliability centred methods to define system maintenance requirements and strategies. This approach has been implemented on a number of systems at Canadian CANDU plants with positive results. The pilot projects demonstrated that the overall maintenance effort remained relatively constant while the system performance improved. It was also possible to schedule some of the redundant component maintenance during plant operation without adverse impact on system availability. The probabilistic safety assessment was found to be useful in determining the safety implications of component outages. These new maintenance strategies are now making use of predictive and condition based maintenance techniques to anticipate equipment breakdown and schedule preventive maintenance as the need arises rather than time based. Some of these techniques include valve diagnostics, vibration monitoring, oil analysis, thermography. Of course, these tools and techniques must form part of an overall maintenance management system to ensure that maintenance becomes a living program. To facilitate this process and contain costs, new information technology tools are being introduced to provide system engineers

  11. Network maintenance

    CERN Multimedia

    GS Department

    2009-01-01

    A site-wide network maintenance operation has been scheduled for Saturday 28 February. Most of the network devices of the general purpose network will be upgraded to a newer software version, in order to improve our network monitoring capabilities. This will result in a series of short (2-5 minutes) random interruptions everywhere on the CERN sites throughout the day. This upgrade will not affect the Computer Centre itself, Building 613, the Technical Network and the LHC experiments, dedicated networks at the pits. For further details of this intervention, please contact Netops by phone 74927 or e-mail mailto:Netops@cern.ch. IT/CS Group

  12. Network maintenance

    CERN Multimedia

    IT Department

    2009-01-01

    A site wide network maintenance has been scheduled for Saturday 28 February. Most of the network devices of the General Purpose network will be upgraded to a newer software version, in order to improve our network monitoring capabilities. This will result in a series of short (2-5 minutes) random interruptions everywhere on the CERN sites along this day. This upgrade will not affect: the Computer centre itself, building 613, the Technical Network and the LHC experiments dedicated networks at the pits. Should you need more details on this intervention, please contact Netops by phone 74927 or email mailto:Netops@cern.ch. IT/CS Group

  13. GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines

    International Nuclear Information System (INIS)

    Morgan, Kevin; Meyer, Colette; Miller, Nicola; Sims, Andrew H; Cagnan, Ilgin; Faratian, Dana; Harrison, David J; Millar, Robert P; Langdon, Simon P

    2011-01-01

    Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells. The applicability of GnRH anti-proliferation to breast cancer was therefore analyzed. GnRH-R expression in 298 primary breast cancer samples was measured by quantitative immunofluorescence. Levels of functional GnRH-R in breast-derived cell lines were assessed using 125 I-ligand binding and stimulation of 3 H-inositol phosphate production. Elevated levels of GnRH-R were stably expressed in cells by transfection. Effects of receptor activation on in vitro cell growth were investigated in comparison with IGF-I and EGF receptor inhibition, and correlated with intracellular signaling using western blotting. GnRH-R immunoscoring was highest in hormone receptor (triple) negative and grade 3 breast tumors. However prior to transfection, functional endogenous GnRH-R were undetectable in four commonly studied breast cancer cell lines (MCF-7, ZR-75-1, T47D and MDA-MB-231). After transfection with GnRH-R, high levels of cell surface GnRH-R were detected in SVCT and MDA-MB-231 clones while low-moderate levels of GnRH-R occurred in MCF-7 clones and ZR-75-1 clones. MCF-7 sub-clones with high levels of GnRH-R were isolated following hygromycin phosphotransferase transfection. High level cell surface GnRH-R enabled induction of high levels of 3 H-inositol phosphate and modest growth-inhibition in SVCT cells. In contrast, growth of MCF-7, ZR-75-1 or MDA-MB-231 clones was unaffected by GnRH-R activation. Cell growth was inhibited by IGF-I or EGF receptor inhibitors. IGF-I receptor inhibitor lowered levels of p-ERK1/2 in MCF-7 clones. Washout of IGF-I receptor inhibitor resulted in transient hyper-elevation of p-ERK1/2, but co-addition of GnRH-R agonist did not alter the dynamics of ERK1/2 re-phosphorylation. Breast cancers exhibit a range of GnRH-R immunostaining, with higher levels of

  14. Environmental impact assessment of wood ash utilization in forest road construction and maintenance--A field study.

    Science.gov (United States)

    Oburger, Eva; Jäger, Anna; Pasch, Alexander; Dellantonio, Alex; Stampfer, Karl; Wenzel, Walter W

    2016-02-15

    The ever increasing use of wood material as fuel for green energy production requires innovative, environmentally safe strategies for recycling of the remaining wood ash. Utilizing wood ash in forest road construction and maintenance to improve mechanical stability has been suggested as a feasible recycling option. To investigate the environmental impact of wood ash application in forest road maintenance, a two-year field experiment was conducted at two Austrian forest sites (Kobernausserwald (KO) (soil pH 5.5) and Weyregg (WE) (pH 7.7)) differing in their soil chemical properties. Two different ashes, one produced by grate incineration (GA) and the other by fluidized bed incineration in a mixture with 15 vol% burnt lime (FBA), were incorporated in repeated road sections at a 15:85% (V/V) ash-to-soil rate. Leaching waters from the road body were collected and analyzed for 32 environmentally relevant parameters over two years. Upon termination of the experiment, sub-road soil samples were collected and analyzed for ash-related changes in soil chemistry. Even though a larger number of parameters was affected by the ash application at the alkaline site (WE), we observed the most pronounced initial increases of pH as well as Al, As, Fe, Mn, Ni, Co, Cu, Mo, and NO2(−) concentrations in leachates beneath GA-treated road bodies at Kobernausserwald due to the lower soil buffer capacity at this site. Despite the observed effects our results indicate that, when specific requirements are met (i.e. appropriate ash quality, sufficient soil buffer capacity below the road body, and single time-point ash incorporation within several decades), wood ash application in forest road construction is generally environmentally acceptable.

  15. Maintenance Plan for the Performance Assessments and Composite Analyses for the Area 3 and Area 5 Radioactive Waste Management Sites at the NTS

    Energy Technology Data Exchange (ETDEWEB)

    Vefa Yucel

    2007-01-03

    U.S. Department of Energy (DOE) Manual M 435.1-1 requires that performance assessments (PAs) and composite analyses (CAs) for low-level waste (LLW) disposal facilities be maintained by the field offices. This plan describes the activities performed to maintain the PA and the CA for the Area 3 and Area 5 Radioactive Waste Management Sites (RWMSs) at the Nevada Test Site (NTS). This plan supersedes the Maintenance Plan for the Performance Assessments and Composite Analyses for the Area 3 and Area 5 Radioactive Waste Management Sites at the Nevada Test Site (DOE/NV/11718--491-REV 1, dated September 2002). The plan is based on U.S. Department of Energy (DOE) Order 435.1 (DOE, 1999a), DOE Manual M 435.1-1 (DOE, 1999b), the DOE M 435.1-1 Implementation Guide DOE G 435.1-1 (DOE, 1999c), and the Maintenance Guide for PAs and CAs (DOE, 1999d). The plan includes a current update on PA/CA documentation, a revised schedule, and a section on Quality Assurance.

  16. Maintenance Plan for the Performance Assessments and Composite Analyses of the Area 3 and Area 5 Radioactive Waste Management Sites at the Nevada Test Site

    International Nuclear Information System (INIS)

    Vefa Yucel

    2007-01-01

    U.S. Department of Energy (DOE) Manual M 435.1-1 requires that performance assessments (PAs) and composite analyses (CAs) for low-level waste (LLW) disposal facilities be maintained by the field offices. This plan describes the activities performed to maintain the PA and the CA for the Area 3 and Area 5 Radioactive Waste Management Sites (RWMSs) at the Nevada Test Site (NTS). This plan supersedes the Maintenance Plan for the Performance Assessments and Composite Analyses for the Area 3 and Area 5 Radioactive Waste Management Sites at the Nevada Test Site (DOE/NV/11718--491-REV 1, dated September 2002). The plan is based on U.S. Department of Energy (DOE) Order 435.1 (DOE, 1999a), DOE Manual M 435.1-1 (DOE, 1999b), the DOE M 435.1-1 Implementation Guide DOE G 435.1-1 (DOE, 1999c), and the Maintenance Guide for PAs and CAs (DOE, 1999d). The plan includes a current update on PA/CA documentation, a revised schedule, and a section on Quality Assurance

  17. Expression of the GnRH and GnRH receptor (GnRH-R) genes in the hypothalamus and of the GnRH-R gene in the anterior pituitary gland of anestrous and luteal phase ewes.

    Science.gov (United States)

    Ciechanowska, Magdalena; Lapot, Magdalena; Malewski, Tadeusz; Mateusiak, Krystyna; Misztal, Tomasz; Przekop, Franciszek

    2008-11-01

    Data exists showing that seasonal changes in the innervations of GnRH cells in the hypothalamus and functions of some neural systems affecting GnRH neurons are associated with GnRH release in ewes. Consequently, we put the question as to how the expression of GnRH gene and GnRH-R gene in the hypothalamus and GnRH-R gene in the anterior pituitary gland is reflected with LH secretion in anestrous and luteal phase ewes. Analysis of GnRH gene expression by RT-PCR in anestrous ewes indicated comparable levels of GnRH mRNA in the preoptic area, anterior and ventromedial hypothalamus. GnRH-R mRNA at different concentrations was found throughout the preoptic area, anterior and ventromedial hypothalamus, stalk/median eminence and in the anterior pituitary gland. The highest GnRH-R mRNA levels were detected in the stalk/median eminence and in the anterior pituitary gland. During the luteal phase of the estrous cycle in ewes, the levels of GnRH mRNA and GnRH-R mRNA in all structures were significantly higher than in anestrous ewes. Also LH concentrations in blood plasma of luteal phase ewes were significantly higher than those of anestrous ewes. In conclusion, results from this study suggest that low expression of the GnRH and GnRH-R genes in the hypothalamus and of the GnRH-R gene in the anterior pituitary gland, amongst others, may be responsible for a decrease in LH secretion and the anovulatory state in ewes during the long photoperiod.

  18. Measurement of 103mRh produced by the 103Rh(γ,γ')103mRh reaction with liquid scintillation counting

    International Nuclear Information System (INIS)

    Sekine, T.; Yoshihara, Kenji; Pavlicsek, I.; Lakosi, L.; Veres, A.

    1989-01-01

    A liquid scintillation counting technique was applied to measure the isotope 103m Rh (half life = 56.12 min) which is difficult to detect because its γ-ray is of low energy and low emission probability. Tris-(2,4-pentanedionato)rhodium(III) (Rh(acac) 3 ) was irradiated with bremsstrahlung of accelerated 3.2 MeV electrons by LINAC. The method has given a reliable calibration curve for the determination of 103m Rh radioactivity below Rh(acac) 3 concentrations of 2 mM. The integrated cross section of 103 Rh(γ,γ') 103m Rh determined by this method was found to be 6.8±3.4 μb MeV at 3.2 MeV. (author) 8 refs.; 5 figs

  19. ABO and Rh blood groups frequency in women with HER2 positive breast cancer.

    Science.gov (United States)

    Urun, Y; Utkan, G; Altundag, K; Arslan, O; Onur, H; Arslan, U Y; Kocer, M; Dogan, I; Senler, F C; Yalcin, B; Demirkazik, A; Akbulut, H; Icli, F

    2012-01-01

    The role of genetic factors in the development of cancer is widely accepted. Data on the role of ABO blood group and Rh factor in breast cancer is inconclusive. The aim of this study was to investigate the presence of a possible association between HER2 (+) breast cancer in Turkish women and ABO blood groups and Rh factor. In 294 female patients with HER2 (+) breast cancer, ABO blood groups and Rh factor were examined. The relationship of blood groups with age, menopausal status, and family history of cancer, estrogen receptor (ER), progesterone receptor (PR) and HER2 status of these patients was evaluated. Blood groups distribution of 22,821 healthy blood donors was also assessed and compared with the patients' blood groups distribution. The median patient age was 47 years (range 20-80) and 56% of the patients were premenopausal. ER and PR were positive in 50 and 60% of the patients, respectively. Overall, the ABO blood group distribution of the 294 HER2 (+) breast cancer patients was similar to that of the healthy blood donors (p=0.36). Likewise there was no correlation between blood type and ER, PR and menopausal status. Rh (-) patients had more frequent family cancer history and this difference was significant for patients with blood group B Rh (-) and O Rh (-) (p = 0.04). In the present study we didn't find any relationship between HER2 status and ABO blood group and Rh factor. However, further studies with larger number of patients are needed to establish the role (if any) of blood groups in patients with breast cancer.

  20. Style et rhétorique

    DEFF Research Database (Denmark)

    Pedersen, Eva de la Fuente

    2006-01-01

    En se forgeant un style presque inimitable, qui paraît ébauché, Rembrandt a suscité l'admiration de ses contemporains. Au-delà son apparente spontanéité, ce style fait certainement écho aux préoccupations des théoriciens de l'art contemporains qui attendaient de la peinture, comme de la rhétorique...

  1. Advantages with prophylactic PEG-rhG-CSF versus rhG-CSF in breast cancer patients receiving multiple cycles of myelosuppressive chemotherapy: an open-label, randomized, multicenter phase III study.

    Science.gov (United States)

    Xie, Jie; Cao, Jun; Wang, Jing-Fen; Zhang, Bai-Hong; Zeng, Xiao-Hua; Zheng, Hong; Zhang, Yang; Cai, Li; Wu, Yu-Dong; Yao, Qiang; Zhao, Xiao-Chun; Mao, Wei-Dong; Jiang, Ai-Mei; Chen, Shao-Shui; Yang, Shun-E; Wang, Shu-Sen; Wang, Jian-Hong; Pan, Yue-Yin; Ren, Bi-Yong; Chen, Yan-Ju; Ouyang, Li-Zhi; Lei, Kai-Jian; Gao, Jing-Hua; Huang, Wen-He; Huang, Zhan; Shou, Tao; He, Yan-Ling; Cheng, Jing; Sun, Yang; Li, Wei-Ming; Cui, Shu-de; Wang, Xin; Rao, Zhi-Guo; Ma, Hu; Liu, Wei; Wu, Xue-Yong; Shen, Wei-Xi; Cao, Fei-Lin; Xiao, Ze-Min; Wu, Biao; Tian, Shu-Yan; Meng, Dong; Shen, Peng; Wang, Bi-Yun; Wang, Zhonghua; Zhang, Jian; Wang, Leiping; Hu, Xi-Chun

    2018-04-01

    PEG-rhG-CSF reduces neutropenia and improves chemotherapy safety. In China's registration trial (CFDA: 2006L01305), we assessed its efficacy and safety against rhG-CSF, and prospectively explored its value over multiple cycles of chemotherapy. In this open-label, randomized, multicenter phase 3 study, breast cancer patients (n = 569) were randomized to receive PEG-rhG-CSF 100 µg/kg, PEG-rhG-CSF 6 mg, or rhG-CSF 5 µg/kg/d after chemotherapy. The primary endpoints were the incidence and duration of grade 3/4 neutropenia during cycle 1. Secondary endpoints included the incidence and duration of grade 3/4 neutropenia during cycles 2-4, the incidence of febrile neutropenia, and the safety. A once-per-cycle PEG-rhG-CSF at either 100 µg/kg or 6 mg was not different from daily injections of rhG-CSF for either incidence or duration of grade 3/4 neutropenia. Interestingly, a substantial difference was noted during cycle 2, and the difference became bigger over cycles 3-4, reaching a statistical significance at cycle 4 in either incidence (P = 0.0309) or duration (P = 0.0289) favoring PEG-rhG-CSF. A significant trend toward a lower incidence of all-grade adverse events was noted at 129 (68.98%), 142 (75.53%), and 160 (82.47%) in the PEG-rhG-CSF 100 µg/kg and 6 mg and rhG-CSF groups, respectively (P = 0.0085). The corresponding incidence of grade 3/4 drug-related adverse events was 2/187 (1.07%), 1/188 (0.53%), and 8/194 (4.12%), respectively (P = 0.0477). Additionally, PFS in metastatic patients preferred PEG-rhG-CSF to rhG-CSF despite no significance observed by Kaplan-Meier analysis (n = 49, P = 0.153). PEG-rhG-CSF is a more convenient and safe formulation and a more effective prophylactic measure in breast cancer patients receiving multiple cycles of chemotherapy.

  2. Rh-Ni and Rh-Co Catalysts for Autothermal Reforming of Gasoline

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Yeongyu; Lee, Daehyung; Kim, Yongmin; Lee, Jinhee; Nam, Sukwoo; Choi, Daeki; Yoon, Chang Won [Korea Institute of Science and Technology, Seoul (Korea, Republic of)

    2014-01-15

    Rh doped Ni and Co catalysts, Rh-M/CeO{sub 2}(20 wt %)-Al{sub 2}O{sub 3} (0.2 wt % of Rh; M = Ni or Co, 20 wt %) were synthesized to produce hydrogen via autothermal reforming (ATR) of commercial gasoline at 700 .deg. C under the conditions of a S/C ratio of 2.0, an O/C ratio of 0.84, and a gas hourly space velocity (GHSV) of 20,000 h{sup -1}. The Rh-Ni/CeO{sub 2}(20 wt %)-Al{sub 2}O{sub 3} catalyst (1) exhibited excellent activities, with H{sub 2} and (H{sub 2}+CO) yields of 2.04 and 2.58 mol/mol C, respectively. In addition, this catalyst proved to be highly stable over 100 h without catalyst deactivation, as evidenced by energy dispersive spectroscopy (EDX) and elemental analyses. Compared to 1, Rh-Co/CeO{sub 2}(20 wt %)-Al{sub 2}O{sub 3} catalyst (2) exhibited relatively low stability, and its activity decreased after 57 h. In line with this observation, elemental analyses confirmed that nearly no carbon species were formed at 1 while carbon deposits (10 wt %) were found at 2 following the reaction, which suggests that carbon coking is the main process for catalyst deactivation.

  3. Nano-objects emitted during maintenance of common particle generators: direct chemical characterization with aerosol mass spectrometry and implications for risk assessments

    Energy Technology Data Exchange (ETDEWEB)

    Nilsson, Patrik T., E-mail: patrik.nilsson@design.lth.se; Isaxon, Christina [Lund University, Ergonomics and Aerosol Technology (Sweden); Eriksson, Axel C. [Lund University, Nuclear Physics (Sweden); Messing, Maria E. [Lund University, Solid State Physics (Sweden); Ludvigsson, Linus; Rissler, Jenny [Lund University, Ergonomics and Aerosol Technology (Sweden); Hedmer, Maria; Tinnerberg, Håkan [Lund University, Division of Occupational and Environmental Medicine, Department of Laboratory Medicine (Sweden); Gudmundsson, Anders [Lund University, Ergonomics and Aerosol Technology (Sweden); Deppert, Knut [Lund University, Solid State Physics (Sweden); Bohgard, Mats; Pagels, Joakim H. [Lund University, Ergonomics and Aerosol Technology (Sweden)

    2013-11-15

    Nanotechnology gives us materials with enhanced or completely new properties. At the same time, inhalation of manufactured nano-objects has been related to an array of adverse biological effects. We characterized particle emissions, which occurred during maintenance of common metal nanoparticle generators and contrasted the properties of the emitted particles with those originally produced by the generators. A new approach using online aerosol mass spectrometry (AMS), for time- and size-resolved measurements of the particle chemical composition, was applied in combination with more conventional techniques for particle sampling and analysis, including electron microscopy. Emissions during maintenance work, in terms of mass and surface area concentration in the size range of 0.02–10 μm, were dominated by large agglomerates (1–5 μm). With AMS, we show that the particle composition depends on both generator type and maintenance task being performed and that the instrument can be used for highly time-resolved selective studies of metal nanoparticle emissions. The emitted agglomerates have a relatively high probability to be deposited in the lower respiratory tract, since the mean particle diameter coincided with a peak in the lung deposition curve. Each of these agglomerates consisted of a very high number (10{sup 3}–10{sup 5}/agglomerate) of nanometer-sized primary particles originating from the particle synthesis process. This made them possess large surface areas, one of the key properties in nanotoxicology. Similar agglomerates may be emitted in a wide range of processes when nanoparticles are manufactured or handled. The fate of such agglomerates, once deposited in the respiratory tract, is unknown and should therefore be considered in future particle toxicological studies. Our results highlight the importance of including micrometer-sized particles in exposure and emission assessments.

  4. Nano-objects emitted during maintenance of common particle generators: direct chemical characterization with aerosol mass spectrometry and implications for risk assessments

    International Nuclear Information System (INIS)

    Nilsson, Patrik T.; Isaxon, Christina; Eriksson, Axel C.; Messing, Maria E.; Ludvigsson, Linus; Rissler, Jenny; Hedmer, Maria; Tinnerberg, Håkan; Gudmundsson, Anders; Deppert, Knut; Bohgard, Mats; Pagels, Joakim H.

    2013-01-01

    Nanotechnology gives us materials with enhanced or completely new properties. At the same time, inhalation of manufactured nano-objects has been related to an array of adverse biological effects. We characterized particle emissions, which occurred during maintenance of common metal nanoparticle generators and contrasted the properties of the emitted particles with those originally produced by the generators. A new approach using online aerosol mass spectrometry (AMS), for time- and size-resolved measurements of the particle chemical composition, was applied in combination with more conventional techniques for particle sampling and analysis, including electron microscopy. Emissions during maintenance work, in terms of mass and surface area concentration in the size range of 0.02–10 μm, were dominated by large agglomerates (1–5 μm). With AMS, we show that the particle composition depends on both generator type and maintenance task being performed and that the instrument can be used for highly time-resolved selective studies of metal nanoparticle emissions. The emitted agglomerates have a relatively high probability to be deposited in the lower respiratory tract, since the mean particle diameter coincided with a peak in the lung deposition curve. Each of these agglomerates consisted of a very high number (10 3 –10 5 /agglomerate) of nanometer-sized primary particles originating from the particle synthesis process. This made them possess large surface areas, one of the key properties in nanotoxicology. Similar agglomerates may be emitted in a wide range of processes when nanoparticles are manufactured or handled. The fate of such agglomerates, once deposited in the respiratory tract, is unknown and should therefore be considered in future particle toxicological studies. Our results highlight the importance of including micrometer-sized particles in exposure and emission assessments

  5. rhBMP-2 (ACS and CRM formulations) overcomes pseudarthrosis in a New Zealand white rabbit posterolateral fusion model.

    Science.gov (United States)

    Lawrence, James P; Waked, Walid; Gillon, Thomas J; White, Andrew P; Spock, Christopher R; Biswas, Debdut; Rosenberger, Patricia; Troiano, Nancy; Albert, Todd J; Grauer, Jonathan N

    2007-05-15

    The study design consisted of a New Zealand white rabbit model of pseudarthrosis repair. Study groups consisting of no graft, autograft, or recombinant human bone morphogenetic protein-2 (rhBMP-2) with absorbable collagen sponge (ACS) or compression resistant matrix (CRM) were evaluated. To evaluate the relative efficacy of bone graft materials (autograft, ACS, and CRM). rhBMP-2 has been shown to have a 100% fusion rate in a primary rabbit fusion model, even in the presence of nicotine, which is known to inhibit fusion. Seventy-two New Zealand white rabbits underwent posterolateral lumbar fusion with iliac crest autograft. To establish pseudarthroses, nicotine was administered to all animals. At 5 weeks, the spines were explored and all pseudarthroses were redecorticated and implanted with no graft, autograft, rhBMP-2/ACS, or rhBMP-2/CRM. At 10 weeks, fusions were assessed by manual palpation and histology. Eight rabbits (11%) were lost to complications. At 5 weeks, 66 (97%) had pseudarthroses. At 10 weeks, attempted pseudarthrosis repairs were fused in 1 of 16 of no graft rabbits (6%), 5 of 17 autograft rabbits (29%), and 31 of 31 rhBMP-2 rabbits (with ACS or CRM) (100%). Histologic analysis demonstrated more mature bone formation in the rhBMP-2 groups. The 2 rhBMP-2 formulations led to significantly higher fusion rates and histologic bone formation than no graft and autograft controls in this pseudarthrosis repair model.

  6. Optimizing preventive maintenance with maintenance templates

    International Nuclear Information System (INIS)

    Dozier, I.J.

    1996-01-01

    Rising operating costs has caused maintenance professionals to rethink their strategy for preventive maintenance (PM) programs. Maintenance Templates are pre-engineered PM task recommendations for a component type based on application of the component. Development of the maintenance template considers the dominant failure cause of the component and the type of preventive maintenance that can predict or prevent the failure from occurring. Maintenance template development also attempts to replace fixed frequency tasks with condition monitoring tasks such as vibration analysis or thermography. For those components that have fixed frequency PM intervals, consideration is given to the maintenance drivers such as criticality, environment and usage. This helps to maximize the PM frequency intervals and maximize the component availability. Maintenance Templates have been used at PECO Energy's Limerick Generating Station during the Reliability Centered Maintenance (RCM) Process to optimize their PM program. This paper describes the development and uses of the maintenance templates

  7. Electronic structure of Rh-based CuRh0.9Mg0.1O2 oxide thermoelectrics

    Science.gov (United States)

    Vilmercati, P.; Martin, E.; Cheney, C. Parks; Bondino, F.; Magnano, E.; Parmigiani, F.; Sasagawa, T.; Mannella, N.

    2013-03-01

    The electronic structure of the Rh-based CuRh0.9Mg0.1O2 oxide thermoelectric compound has been studied with a multitechnique approach consisting of photoemission, x-ray absorption, and x-ray emission spectroscopies. The data indicate that the region of the valence band in the proximity of the Fermi level is dominated by Rh-derived states. These findings outline the importance of the electronic structure of the Rh ions for the large thermoelectric power in CuRh0.9Mg0.1O2 at high temperature.

  8. Preparation and evaluation of self-microemulsions for improved bioavailability of ginsenoside-Rh1 and Rh2.

    Science.gov (United States)

    Yang, Feifei; Zhou, Jing; Hu, Xiao; Yu, Stephanie Kyoungchun; Liu, Chunyu; Pan, Ruile; Chang, Qi; Liu, Xinmin; Liao, Yonghong

    2017-10-01

    Due to intestinal cytochrome P450 (CYP450)-mediated metabolism and P-glycoprotein (P-gp) efflux, poor oral bioavailability hinders ginsenoside-Rh1 (Rh1) and ginsenoside-Rh2 (Rh2) from clinical application. In this study, Rh1 and Rh2 were incorporated into two self-microemulsions (SME-1 and SME-2) to improve oral bioavailability. SME-1 contained both CYP450 and P-gp inhibitory excipients while SME-2 only consisted of P-gp inhibitory excipients. Results for release, cellular uptake, transport, and lymph node distribution demonstrated no significant difference between either self-microemulsions in vivo, but were elevated significantly in comparison to the free drug. The pharmaceutical profiles in vivo showed that the bioavailability of Rh1 in SME-1 (33.25%) was significantly higher than that in either SME-2 (21.28%) or free drug (12.92%). There was no significant difference in bioavailability for Rh2 between SME-1 (48.69%) or SME-2 (41.73%), although they both had remarkable increase in comparison to free drug (15.02%). We confirmed that SME containing CYP450 and P-gp inhibitory excipient could distinctively improve the oral availabilities of Rh1 compared to free drug or SME containing P-gp inhibitory excipient. No notable increase was observed between either SME for Rh2, suggesting that Rh2 undergoes P-gp-mediated efflux, but may not undergo distinct CYP450-mediated metabolism.

  9. A computer calculation of the ternary Mo-Pd-Rh phase diagram

    International Nuclear Information System (INIS)

    Guerler, R.; Pratt, J.N.

    1993-01-01

    Thermodynamic coefficients for the phases in the binary Mo-Pd, Pd-Rh and Mo-Rh systems were derived by the assessment of the available experimental data using the binary Lukas optimization program. The resulting coefficients were first successfully utilised in reestablishing the binaries. The coefficients thus obtained in the binary computation were combined with ternary descriptions to compute ternary isothermal sections. Although no ternary interaction term was involved in the construction of the isotherms, the section calculated at 1373 K is found to be consistent with the experimentally established isothermal section at the same temperature. The location of three-phase field (bcc+hcp+fcc) and phase boundaries in both isotherms are matching reasonably well. Combining only binary coefficients of these phases, it is possible to construct reasonable isothermal sections at different temperatures. Following this conclusion, isothermal sections ranging from 1373 to 2673 K of the ternary Mo-Pd-Rh system were calculated. (orig.)

  10. Assessing the potential spread and maintenance of foot-and-mouth disease virus infection in wild ungulates: general principles and application to a specific scenario in Thrace.

    Science.gov (United States)

    Dhollander, S; Belsham, G J; Lange, M; Willgert, K; Alexandrov, T; Chondrokouki, E; Depner, K; Khomenko, S; Özyörük, F; Salman, M; Thulke, H H; Bøtner, A

    2016-04-01

    Foot-and-mouth disease (FMD), due to infection with serotype O virus, occurred in wild boar and within eleven outbreaks in domestic livestock in the south-east of Bulgaria, Thrace region, in 2011. Hence, the issue of the potential for the spread and maintenance of FMD virus (FMDV) infection in a population of wild ungulates became important. This assessment focused on the spread and maintenance of FMDV infection within a hypothetical wild boar and deer population in an environment, which is characterized by a climate transitional between Mediterranean and continental and variable wildlife population densities. The assessment was based on three aspects: (i) a systematic review of the literature focusing on experimental infection studies to identify the parameters describing the duration of FMDV infection in deer and wild boar, as well as observational studies assessing the occurrence of FMDV infection in wild deer and wild boar populations, (ii) prevalence survey data of wild boar and deer in Bulgaria and Turkey and (iii) an epidemiological model, simulating the host-to-host spread of FMDV infections. It is concluded, based on all three aspects, that the wildlife population in Thrace, and so wildlife populations in similar ecological settings, are probably not able to maintain FMD in the long term in the absence of FMDV infection in the domestic host population. However, limited spread of FMDV infection in time and space in the wildlife populations can occur. If there is a continued cross-over of FMDV between domestic and wildlife populations or a higher population density, virus circulation may be prolonged. © 2014 Blackwell Verlag GmbH.

  11. Guidelines for Remote Handling Maintenance of ITER Neutral Beam Components

    International Nuclear Information System (INIS)

    Cordier, J.-J.; Hemsworth, R.; Bayetti, P.

    2006-01-01

    Remote handling maintenance of ITER components is one of the main challenges of the ITER project. This type of maintenance shall be operational for the nuclear phase of exploitation of ITER, and be considered at a very early stage since it significantly impacts on the components design, interfaces management and integration business. A large part of the R/H equipment will be procured by the EU partner, in particular the whole Neutral Beam Remote Handling (RH) equipment package. A great deal of work has already been done in this field during the EDA phase of ITER project, but improvements and alternative option that are now proposed by ITER lead to added RH and maintenance engineering studies. The Neutral Beam Heating -and- Current Drive system 1 is being revisited by the ITER project. The vertical maintenance scheme that is presently considered by ITER, may significantly impact on the reference design of the Neutral Beam (NB) system and associated components and lead to new design of the NB box itself. In addition, revision of both NB cell radiation level zoning and remote handling classification of the beam line injector will also significantly impact on components design and maintenance. Based on the experience gained on the vertical maintenance scheme, developed in detail for the ITER Neutral Beam Test Facility 2 to be built in Europe in a near future, guidelines for the revision of the design and preliminary feasibility study of the remote handling vertical maintenance scheme of beam line components are described in the paper. A maintenance option for the SINGAP3 accelerator is also presented. (author)

  12. Evolving trends: hyperbilirubinemia among newborns delivered to rh negative mothers in southern India.

    Science.gov (United States)

    N, Girish; S, Santosh; Sr, Keshavamurthy

    2013-11-01

    Neonatal jaundice is the commonest abnormal physical finding in the new born nursery and hemolytic disease of the newborn (HDN) among babies born to Rh negative mothers is the most formidable etiology. During last few decades considerable evolution has been observed in this entity secondary to development of several novel preventive, diagnostic and therapeutic modalities. To study the current trends in presentation, management and outcome of hyperbilirubinemia among newborns delivered to Rh negative mothers. This observational descriptive study with prospective data collection included one hundred live born term babies born to Rh negative mothers in our hospital. A predesigned proforma was used to record antenatal and postnatal data .Cord blood collected during delivery for assessment of bilirubin,hematocrit and direct coombs test.Serum bilirubin levels were estimated in babies with clinical jaundice and treated for the same if required.All babies were regularly followed up weekly for one month. Chi square test/Fisher Exact test and Student "t" test has been used to find the significant association of jaundice(incidence,treatment) and study characteristics. Out of 100 babies enrolled, 57 babies developed jaundice. Jaundice is 2.7 times more likely associated with babies born to multiparous Rh-ve mothers with p=0.017*. Jaundice is 3 times more likely associated with Rh+ve babies born to multiparous mothers with p=0.020*. Jaundice is 3.97 times more likely associated with Rh+ve babies born to multiparous mothers who have not received Anti-D with p=0.154. Treatment of jaundice is 2.75 times more likely in Rh+ve babies born to multiparous mothers who have not received Anti-D with p=0.162. Duration of phototherapy is significantly more in Rh+ve babies born to multiparous mothers who had not received Anti-D with p=0.0097*.Exchange transfusion was required in two babies. Although the incidence of Rh isoimmunization has declined dramatically over the years ,it is still an

  13. Routine noninvasive prenatal screening for fetal RHD in plasma of RhD-negative pregnant women-2years of screening experience from Denmark

    DEFF Research Database (Denmark)

    Clausen, F. Banch; Steffensen, R.; Christiansen, M.

    2014-01-01

    Objective: Prenatal and postnatal RhD prophylaxis reduces the risk of RhD immunization in pregnancies of RhD-negative women. Based on the result from prenatal screening for the fetal RHD gene, prenatal RhD prophylaxis in Denmark is targeted to RhD-negative women who carry an RhD-positive fetus...... of newborns in 12,668 pregnancies. Early compliance was assessed for 690 pregnancies. Results: The sensitivity for the detection of fetal RHD was 99.9% (95% CI: 99.7-99.9%). Unnecessary recommendation of prenatal RhD prophylaxis was avoided in 97.3% of the women carrying an RhD-negative fetus. Fetuses...... that were seropositive for RhD were not detected in 11 pregnancies (0.087%). The sample uptake percentage was 84.2%, and the compliance for prenatal anti-D administration was 93.2%. Conclusion: The high sensitivity, maintained over 2years, underlines the reliability of routine prenatal fetal RHD screening...

  14. Immuno-modulatory effect of local rhEGF treatment during tissue repair in diabetic ulcers.

    Science.gov (United States)

    García-Honduvilla, Natalio; Cifuentes, Alberto; Ortega, Miguel A; Pastor, Marta; Gainza, Garazi; Gainza, Eusebio; Buján, Julia; Álvarez-Mon, Melchor

    2018-04-01

    Wound healing is a complex process that can be severely impaired due to pathological situations such as diabetes mellitus. Diabetic foot ulcers are a common complication of this pathology and are characterized by an excessive inflammatory response. In this work, the effects of local treatment with recombinant human epidermal growth factor (rhEGF) were studied using a full-thickness wound healing model in streptozotocin-induced diabetic rats. Wound healing process was assessed with different concentrations of rhEGF (0.1, 0.5, 2.0 and 8.0 µg/mL), placebo and both diabetic and non-diabetic controls ( n  = 53). The macroscopic healing observed in treated diabetic rats was affected by rhEGF concentration. Histologically, we also observed an improvement in the epithelialization, granulation tissue formation and maturation in treated groups, finding again the best response at doses of 0.5 and 2.0 µg/mL. Afterwards, the tissue immune response over time was assessed in diabetic rats using the most effective concentrations of rhEGF (0.5 and 2.0 µg/mL), compared to controls. The presence of macrophages, CD4 + T lymphocytes and CD8 + T lymphocytes, in the reparative tissue was quantified, and cytokine expression was measured by quantitative real-time PCR. rhEGF treatment caused a reduction in the number of infiltrating macrophages in the healing tissue of diabetic, as well as diminished activation of these leukocytes. These findings show that local administration of rhEGF improves the healing process of excisional wounds and the quality of the neoformed tissue in a dose-dependent manner. Besides, this treatment reduces the local inflammation associated with diabetic healing, indicating immuno-modulatory properties. © 2018 The authors.

  15. Experience in the implementation of quality assurance program and safety culture assessment of research reactor operation and maintenance

    International Nuclear Information System (INIS)

    Syarip; Suryopratomo, K.

    2001-01-01

    The implementation of quality assurance program and safety culture for research reactor operation are of importance to assure its safety status. It comprises an assessment of the quality of both technical and organizational aspects involved in safety. The method for the assessment is based on judging the quality of fulfillment of a number of essential issues for safety i.e. through audit, interview and/or discussions with personnel and management in plant. However, special consideration should be given to the data processing regarding the fuzzy nature of the data i.e. in answering the questionnaire. To accommodate this situation, the SCAP, a computer program based on fuzzy logic for assessing plant safety status, has been developed. As a case study, the experience in the assessment of Kartini research reactor safety status shows that it is strongly related to the implementation of quality assurance program in reactor operation and awareness of reactor operation staffs to safety culture practice. It is also shown that the application of the fuzzy rule in assessing reactor safety status gives a more realistic result than the traditional approach. (author)

  16. The type of GnRH analogue used during controlled ovarian stimulation influences early embryo developmental kinetics

    DEFF Research Database (Denmark)

    Muñoz, Manuel; Cruz, María; Humaidan, Peter

    2013-01-01

    in the Instituto Valenciano de Infertilidad (IVI) Alicante and the Instituto Universitario-IVI Valencia, Spain, 2817 embryos deriving from 400 couples undergoing oocyte donation were analysed. After controlled ovarian stimulation and IVF/intracytoplamic sperm injection, the timing of embryonic cleavages......OBJECTIVE: To explore if the GnRH analogue used for controlled ovarian stimulation (COS) and the ovulation triggering factor (GnRH agonist+hCG triggering versus GnRH antagonist+GnRH agonist triggering) affect embryo development and kinetics. STUDY DESIGN: In a retrospective cohort study...... was assessed by a video time-lapse system. The results were analysed using Student's t test for comparison of timings (hours) and Chi-squared test for comparison of proportions. A p-value...

  17. Photonuclear excitation of 103Rh by synchrotron radiation

    International Nuclear Information System (INIS)

    Kaji, Harumi; Yoshihara, Kenji; Mukoyama, Takeshi; Nakajima, Tetsuo

    1989-01-01

    Photonuclear excitation of 103 Rh nucleus was studied by the use of synchrotron radiation at KEK. Formation of excited state was confirmed by observing Rh K X-rays emitted following the isomeric transition of 103m Rh with a low-energy photon spectrometer. The induced activity due to 103 Rh(γ,γ') 103m Rh reaction was determined carefully by subtracting the fluorescent K X-rays due to natural background radiation. The integral cross-section for 103m Rh by resonance absorption at 295 keV is found to be (1∼2)x10 -28 cm 2 ·eV and is compared with that estimated from the previous experimental value for the 1277-keV level and the calculated value

  18. Preventive maintenance and life time assessment with respect to cyclic operation; Foerebyggande underhaall och livslaengdsbedoemning med avseende paa cyklisk drift

    Energy Technology Data Exchange (ETDEWEB)

    Storesund, Jan

    2011-03-15

    Procedures that may be used for the life time assessments and growth laws for failure mechanisms with respect to cyclic operation has been compiled. Experience and analyzes of the effects of cyclical operation of steam drums, steam boxes, steam accumulators and valves has been compiled. For the strain-induced corrosion cracking in steam drums a correlation between the voltage level and the crack growth rate has been developed.

  19. Maintenance Business Plans.

    Science.gov (United States)

    Adams, Matt

    2002-01-01

    Discusses maintenance business plans, statements which provide accountability for facilities maintenance organizations' considerable budgets. Discusses the plan's components: statement of plan objectives, macro and detailed description of the facility assets, maintenance function descriptions, description of key performance indicators, milestone…

  20. Maintenance Management Update.

    Science.gov (United States)

    Sternloff, Robert E.

    1987-01-01

    Current trends in park maintenance are overviewed, including maintenance impact statements, avoidance of cost through efficient use and national resource conservation, horticultural accomplishments that influence maintenance management, and vandalism prevention. (CB)

  1. {sup 103}Rh-NMR studies in the superconductor Rh{sub 17}S{sub 15}

    Energy Technology Data Exchange (ETDEWEB)

    Koyama, T; Kanda, K; Ueda, K; Mito, T; Kohara, T [Graduate School of Material Science, University of Hyogo, Kamigori, Hyogo 678-1297 (Japan); Nakamura, H, E-mail: t-koyama@sci.u-hyogo.ac.j [Department of Materials Science and Engineering, Kyoto University, Kyoto 606-8501 (Japan)

    2010-01-15

    {sup 103}Rh nuclear magnetic resonance (NMR) measurements have been performed in the superconductor Rh{sub 17}S{sub 15} with the transition temperature T{sub C}=5.4 K. The observed {sup 103}Rh-NMR spectrum shows an asymmetric shape with several peaks, reflecting the local symmetry around each Rh site. We have identified the observed NMR lines corresponding to four different Rh sites and obtained the temperature (T) dependence of the Knight shift of 24m site. The isotropic part of the Knight shift K{sub iso} decreases with decreasing T, indicating the existence of the electron correlation in Rh{sub 17}S{sub 15}. In the superconducting state, the resonance lines shift to higher frequencies owing to a decrease of the spin part of the Knight shift with negative hyperfine coupling.

  2. BaroFuse, a novel pressure-driven, adjustable-throughput perfusion system for tissue maintenance and assessment

    Directory of Open Access Journals (Sweden)

    Austin Rountree

    2016-12-01

    Conclusions: The very low flow rates and simplicity of design and operation of the BaroFuse device allow for the efficient generation of large number of kinetic profiles in OCR and other endpoints lasting from hours to days. The use of flow enhances the ability to make measurements on primary tissue where some elements of native three-dimensional structure are preserved. We offer the BaroFuse as a powerful tool for physiological studies and for pharmaceutical assessment of drug effects as well as personalized medicine.

  3. Assessing the Association between Serum Ferritin, Transferrin Saturation, and C-Reactive Protein in Northern Territory Indigenous Australian Patients with High Serum Ferritin on Maintenance Haemodialysis

    Directory of Open Access Journals (Sweden)

    Sandawana William Majoni

    2017-01-01

    Full Text Available Objective. To determine the significance of high serum ferritin observed in Indigenous Australian patients on maintenance haemodialysis in the Northern Territory, we assessed the relationship between ferritin and transferrin saturation (TSAT as measures of iron status and ferritin and C-reactive protein (CRP as markers of inflammation. Methods. We performed a retrospective cohort analysis of data from adult patients (≥18 years on maintenance haemodialysis (>3 months from 2004 to 2011. Results. There were 1568 patients. The mean age was 53.9 (11.9 years. 1244 (79.3% were Indigenous. 44.2% (n=693 were male. Indigenous patients were younger (mean age [52.3 (11.1 versus 57.4 (15.2, p<0.001] and had higher CRP [14.7 mg/l (7–35 versus 5.9 mg/l (1.9–17.5, p<0.001], higher median serum ferritin [1069 µg/l (668–1522 versus 794.9 µg/l (558.5–1252.0, p<0.001], but similar transferrin saturation [26% (19–37 versus 28% (20–38, p=0.516]. We observed a small positive correlation between ferritin and TSAT (r2=0.11, p<0.001, no correlation between ferritin and CRP (r2 = 0.001, p<0.001, and positive association between high serum ferritin and TSAT (p<0.001, Indigenous ethnicity (p<0.001, urea reduction ratio (p=0.001, and gender (p<0.001 after adjustment in mixed regression analysis. Conclusion. Serum ferritin and TSAT may inadequately reflect iron status in this population. The high ferritin was poorly explained by inflammation.

  4. Remote handling dynamical modelling: assessment on new approach to enhance positioning accuracy with heavy load manipulation

    International Nuclear Information System (INIS)

    Gagarina-Sasia, T.; David, O.; Dubus, G.; Perrot, Y.; Riwain, A.

    2007-01-01

    In vessel maintenance work in Fusion Tokamak will be carried out with help several sets of robotic devices. Heavy loads handling in constrained space is identified by all players of the RH community as a key-issue in the latest Fusion Tokamak facilities. To deal with high-level dexterity tasks, high payload to mass ratio and limited operating space, RH equipment designers can only propose systems whose mechanical flexibility is no longer negligible and need to be taken into account in the control scheme. Traditional approaches where control system only includes a linear model of deformation of the structure leads to poor positioning accuracy. Uncontrolled or under evaluated errors could be damaging for in-vessel components during maintenance operations in the Tokamak facility. To address the control of complex flexible systems, we will investigate the use of specific mechanical software that combines both finite element and kinematical joints analyses, with a strong-coupled formulation, to perform system dynamics simulations. This procedure will be applied on a single axis mock up robotic joint with highly flexible structure. A comparison of experimental results with the traditional linear approach and the specified software model will be carried out. Benefits introduced by this new approach will finally be assessed in view of RH design or specification in the field of RH in Fusion Tokamak scale such as ITER. (orig.)

  5. Multi-purpose deployer for ITER in-vessel maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chang-Hwan, E-mail: Chang-Hwan.CHOI@iter.org [ITER Organization, Route de Vinon-sur-Verdon, 13115 St Paul lez Durance (France); Tesini, Alessandro; Subramanian, Rajendran [ITER Organization, Route de Vinon-sur-Verdon, 13115 St Paul lez Durance (France); Rolfe, Alan; Mills, Simon; Scott, Robin; Froud, Tim; Haist, Bernhard; McCarron, Eddie [Oxford Technologies Ltd., 7 Nuffield Way, Abingdon, OXON (United Kingdom)

    2015-10-15

    Highlights: • ITER RH system called as the multi-purpose deployer (MPD) is introduced. • The MPD performs dust and tritium inventory control, in-service inspection. • The MPD performs leak localization, in-vessel diagnostics maintenance. • The MPD has nine degrees of freedom with a payload capacity up to 2 tons. - Abstract: The multi-purpose deployer (MPD) is a general purpose in-vessel remote handling (RH) system in the ITER RH system. The MPD provides the means for deployment and handling of in-vessel tools or components inside the vacuum vessel (VV) for dust and tritium inventory control, in-service inspection, leak localization, and in-vessel diagnostics. It also supports the operation of blanket first wall maintenance and neutral beam duct liner module maintenance operations. This paper describes the concept design of the MPD. The MPD is a cask based system, i.e. it stays in the hot cell building during the machine operation, and is deployed to the VV using the cask system for the in-vessel operations. The main part of the MPD is the articulated transporter which provides transportation and positioning of the in-vessel tools or components. The articulated transporter has nine degrees of freedom with a payload capacity up to 2 tons. The articulated transporter can cover the whole internal surface of the VV by switching between the four equatorial RH ports. Additionally it can use two non-RH equatorial ports to transfer large tools or components. A concept for in-cask tool exchange is developed which minimizes the cask transportation by allowing the MPD to stay in the VV during the tool exchange.

  6. Pacific Northwest Laboratory Maintenance Implementation plan

    International Nuclear Information System (INIS)

    Bright, J.D.

    1992-06-01

    This Maintenance Implementation plan has been developed for Pacific Northwest Laboratory's (PNL) Nuclear Facilities: 306W, 324, 325, 327 and 329NMF. It is based on a graded approach, self-assessment of the existing maintenance program(s) per the requirements specified by US Department of Energy (DOE) Order 4330.4A, Chapter II, Change number-sign 3. The results of this assessment were evaluated to determine needed improvements in PNL Craft Services' current maintenance program. The objective of this implementation plan is to provide baseline information for compliance to the DOE 4330.4A, and for needed improvements. The prime consideration in applying a graded approach to the Order has been to maintain safe and reliable operations, environmental compliance, safeguards and security, programmatic mission, facility preservation, and/or other facility-specific requirements. Using the results of the self-assessment, PNL has selected nine of the 18 elements of the Maintenance Program defined by DOE Order 4330.4A for improvement. The elements selected for improvement are Training and Qualification of Maintenance Personnel; Maintenance Procedures; Planning, Scheduling, and Coordination of Maintenance; Control of Maintenance Activities; Post-Maintenance Testing; Facility Condition Inspection; Management Involvement; Maintenance History; and Additional Maintenance Requirements. Based upon graded approach and current funding, those elements considered most important have been selected as goals for earliest compliance. Commitment dates for these elements have been established for compliance. The remaining elements of noncompliance will be targeted for implementation during later budget periods

  7. GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile.

    Science.gov (United States)

    Chaudhari, Nirja; Dawalbhakta, Mitali; Nampoothiri, Laxmipriya

    2018-04-11

    GnRH is the master molecule of reproduction that is influenced by several intrinsic and extrinsic factors such as neurotransmitters and neuropeptides. Any alteration in these regulatory loops may result in reproductive-endocrine dysfunction such as the polycystic ovarian syndrome (PCOS). Although low dopaminergic tone has been associated with PCOS, the role of neurotransmitters in PCOS remains unknown. The present study was therefore aimed at understanding the status of GnRH regulatory neurotransmitters to decipher the neuroendocrine pathology in PCOS. PCOS was induced in rats by oral administration of letrozole (aromatase inhibitor). Following PCOS validation, animals were assessed for gonadotropin levels and their mRNA expression. Neurotrasnmitter status was evaluated by estimating their levels, their metabolism and their receptor expression in hypothalamus, pituitary, hippocampus and frontal cortex of PCOS rat model. We demonstrate that GnRH and LH inhibitory neurotransmitters - serotonin, dopamine, GABA and acetylcholine - are reduced while glutamate, a major stimulator of GnRH and LH release, is increased in the PCOS condition. Concomitant changes were observed for neurotransmitter metabolising enzymes and their receptors as well. Our results reveal that increased GnRH and LH pulsatility in PCOS condition likely result from the cumulative effect of altered GnRH stimulatory and inhibitory neurotransmitters in hypothalamic-pituitary centre. This, we hypothesise, is responsible for the depression and anxiety-like mood disorders commonly seen in PCOS women.

  8. Large magnetoresistance in Er7Rh3

    International Nuclear Information System (INIS)

    Sengupta, Kaushik; Sampathkumaran, E.V.

    2005-01-01

    The compound Er 2 Rh 3 has been known to order antiferromagnetically below (T N =14K), and to exhibit a change in the sign of temperature coefficient of electrical resistivity (ρ) in the paramagnetic state around 120 K. Here we report the influence of external magnetic field (H) on the ρ(T) behavior of this compound (1.8-300 K). While the ρ behavior in the paramagnetic state, qualitatively speaking, is found to be robust to the application of H, the magnitude of the magnetoresistance (MR) is significant for moderate applications of H, even at temperatures for above T N untypical of metallic systems. In addition, large values are observed in the magnetically ordered state. (author)

  9. Rh Factor: How It Can Affect Your Pregnancy

    Science.gov (United States)

    ... father or the mother. Can the Rh factor cause problems during pregnancy? Yes. During pregnancy, problems can occur if you ... can die from anemia. Can the Rh factor cause problems during my first pregnancy? Health problems usually do not occur during an ...

  10. Photoelectrochemical properties of LaRhO3

    International Nuclear Information System (INIS)

    Viswanathan, B.; Narayanan, S.R.; Viswanath, R.P.; Varadrajan, T.K.

    1982-01-01

    The photoelectrochemical properties of LaRhO 3 at different values of pH were studied by current-voltage measurements and cyclic voltammetry and the results obtained are compared with those obtained for LaRhO 3 , a potential photoelectrode. (author)

  11. GnRH injection before artificial insemination (AI) alters follicle ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-08-04

    Aug 4, 2009 ... releasing hormone (GnRH) injection on day 6 of the estrous cycle. The estrous cycles ... follicle at the time of GnRH injection (Silcox et al., 1993;. Twagiramungu .... Waves and their Effect on pregnancy rate in the Cow. Reprod.

  12. The effect of maintenance policy violations

    NARCIS (Netherlands)

    Rijsdijk, Christiaan; Tinga, Tiedo

    2014-01-01

    Motivation Maintenance policy assessments usually rely on expert judgement. We seek for some history based validation. Organisations may use our inference to assess risks of maintenance policy violations. Approach We depart from the arbitrary viewpoint that decisions have observable effects. We

  13. ITER Remote Maintenance System (IRMS) lifecycle management

    Energy Technology Data Exchange (ETDEWEB)

    Tesini, Alessandro, E-mail: alessandro.tesini@iter.org [ITER Organization, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Otto' , Bede [Oxford Technologies Ltd, 7, Nuffield Way, Abingdon, Oxon OX14 1RJ (United Kingdom); Blight, John [FAAST 31c Allee de la Granette, 13600 Ceyreste (France); Choi, Chang-Hwan; Friconneau, Jean-Pierre; Gotewal, Krishan Kumar; Hamilton, David [ITER Organization, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Heckendorn, Frank [FD Technologies, PO Box 6686, Aiken, SC (United States); Martins, Jean-Pierre [ITER Organization, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Marty, Thomas [Westinghouse, 122, avenue de Hambourg, 13008 Marseille (France); Nakahira, Masataka; Palmer, Jim; Subramanian, Rajendran [ITER Organization, CS 90 046, 13067 St. Paul Lez Durance Cedex (France)

    2011-10-15

    The availability of the ITER machine to perform its scientific program is strongly dependent on the performance of the different Remote Handling (RH) systems constituting the ITER Remote Maintenance System (IRMS). The lifecycle of the IRMS will largely exceed 40 years from initial concept design and proof testing through to machine decommissioning. Such a long lifecycle requires that a rigorous approach is put in place to guarantee the technical capabilities of the highly innovative IRMS, its efficiency and its availability. For this purpose, an IRMS System Engineering and IRMS lifecycle management approach has been adopted by ITER. The approach aims at ensuring the IRMS full operability and availability at an acceptable cost of ownership over the full ITER machine assembly and operations period. The IRMS lifecycle management method described in this paper covers such subjects as specific requirements for IRMS design reviews, monitoring during manufacture, factory and site acceptance testing, integrated commissioning, decontamination, maintenance and re-qualification strategies, requirements for Integrated Logistical Support during operations. The updating and implementation of the IRMS lifecycle strategy and this procedure will be managed and monitored by the Remote Handling Integrated Product Team (RH-IPT). Although developed for the IRMS, the basic principles and procedures of lifecycle management could be applied to other ITER plant systems whose reliability and availability will be essential for the continued operation of the ITER machine.

  14. ITER Remote Maintenance System (IRMS) lifecycle management

    International Nuclear Information System (INIS)

    Tesini, Alessandro; Otto', Bede; Blight, John; Choi, Chang-Hwan; Friconneau, Jean-Pierre; Gotewal, Krishan Kumar; Hamilton, David; Heckendorn, Frank; Martins, Jean-Pierre; Marty, Thomas; Nakahira, Masataka; Palmer, Jim; Subramanian, Rajendran

    2011-01-01

    The availability of the ITER machine to perform its scientific program is strongly dependent on the performance of the different Remote Handling (RH) systems constituting the ITER Remote Maintenance System (IRMS). The lifecycle of the IRMS will largely exceed 40 years from initial concept design and proof testing through to machine decommissioning. Such a long lifecycle requires that a rigorous approach is put in place to guarantee the technical capabilities of the highly innovative IRMS, its efficiency and its availability. For this purpose, an IRMS System Engineering and IRMS lifecycle management approach has been adopted by ITER. The approach aims at ensuring the IRMS full operability and availability at an acceptable cost of ownership over the full ITER machine assembly and operations period. The IRMS lifecycle management method described in this paper covers such subjects as specific requirements for IRMS design reviews, monitoring during manufacture, factory and site acceptance testing, integrated commissioning, decontamination, maintenance and re-qualification strategies, requirements for Integrated Logistical Support during operations. The updating and implementation of the IRMS lifecycle strategy and this procedure will be managed and monitored by the Remote Handling Integrated Product Team (RH-IPT). Although developed for the IRMS, the basic principles and procedures of lifecycle management could be applied to other ITER plant systems whose reliability and availability will be essential for the continued operation of the ITER machine.

  15. Photonuclear excitation of 103Rh by synchrotron radiation

    International Nuclear Information System (INIS)

    Yoshihara, Kenji; Kaji, Harumi; Sekine, Tsutomu; Mukoyama, Takeshi

    1989-01-01

    Photonuclear excitation of the 103 Rh nucleus was studied using synchrotron radiation. Formation of the excited state was confirmed by observing K X-rays emitted following the isomeric transition of the 103m Rh with a low-energy photon spectrometer. The intensity of induced activity due to 103 Rh(γ,γ') 103m Rh reaction was determined carefully by subtracting the fluorescent K X-rays due to natural background radiation. The integral cross-section for isomer production of 103m Rh by resonance absorption of photons at 295 keV is found to be (2.1±0.8) x 10 -28 cm 2 eV and is compared with that estimated from the previous experimental value for the 1277-keV level. (author)

  16. A Situational Maintenance Model

    DEFF Research Database (Denmark)

    Luxhoj, James T.; Thorsteinsson, Uffe; Riis, Jens Ove

    1997-01-01

    An overview of trend in maintenance management and presentation of a situational model and an analytical tools for identification of managerial efforts in maintenance.......An overview of trend in maintenance management and presentation of a situational model and an analytical tools for identification of managerial efforts in maintenance....

  17. Predicting maintenance of attendance at walking groups: testing constructs from three leading maintenance theories.

    Science.gov (United States)

    Kassavou, Aikaterini; Turner, Andrew; Hamborg, Thomas; French, David P

    2014-07-01

    Little is known about the processes and factors that account for maintenance, with several theories existing that have not been subject to many empirical tests. The aim of this study was to test how well theoretical constructs derived from the Health Action Process Approach, Rothman's theory of maintenance, and Verplanken's approach to habitual behavior predicted maintenance of attendance at walking groups. 114 participants, who had already attended walking groups in the community for at least 3 months, completed a questionnaire assessing theoretical constructs regarding maintenance. An objective assessment of attendance over the subsequent 3 months was gained. Multilevel modeling was used to predict maintenance, controlling for clustering within walking groups. Recovery self-efficacy predicted maintenance, even after accounting for clustering. Satisfaction with social outcomes, satisfaction with health outcomes, and overall satisfaction predicted maintenance, but only satisfaction with health outcomes significantly predicted maintenance after accounting for clustering. Self-reported habitual behavior did not predict maintenance despite mean previous attendance being 20.7 months. Recovery self-efficacy, and satisfaction with health outcomes of walking group attendance appeared to be important for objectively measured maintenance, whereas self-reported habit appeared not to be important for maintenance at walking groups. The findings suggest that there is a need for intervention studies to boost recovery self-efficacy and satisfaction with outcomes of walking group attendance, to assess impact on maintenance.

  18. GnRH agonist versus GnRH antagonist in in vitro fertilization and embryo transfer (IVF/ET

    Directory of Open Access Journals (Sweden)

    Depalo Raffaella

    2012-04-01

    Full Text Available Abstract Several protocols are actually available for in Vitro Fertilization and Embryo Transfer. The review summarizes the main differences and the clinic characteristics of the protocols in use with GnRH agonists and GnRH antagonists by emphasizing the major outcomes and hormonal changes associated with each protocol. The majority of randomized clinical trials clearly shows that in “in Vitro” Fertilization and Embryo Transfer, the combination of exogenous Gonadotropin plus a Gonadotropin Releasing Hormone (GnRH agonist, which is able to suppress pituitary FSH and LH secretion, is associated with increased pregnancy rate as compared with the use of gonadotropins without a GnRH agonist. Protocols with GnRH antagonists are effective in preventing a premature rise of LH and induce a shorter and more cost-effective ovarian stimulation compared to the long agonist protocol. However, a different synchronization of follicular recruitment and growth occurs with GnRH agonists than with GnRH antagonists. Future developments have to be focused on timing of the administration of GnRH antagonists, by giving a great attention to new strategies of stimulation in patients in which radio-chemotherapy cycles are needed.

  19. Hydrodeoxygenation of Phenol to Benzene and Cyclohexane on Rh(111) and Rh(211) Surfaces: Insights from Density Functional Theory

    DEFF Research Database (Denmark)

    Garcia-Pintos, Delfina; Voss, Johannes; Jensen, Anker Degn

    2016-01-01

    Herein we describe the C-O cleavage of phenol and cyclohexanol over Rh (111) and Rh (211) surfaces using density functional theory calculations. Our analysis is complemented by a microkinetic model of the reactions, which indicates that the C-O bond cleavage of cyclohexanol is easier than that of...

  20. Assessment of cold-chain maintenance in vaccine carriers during Pulse Polio National Immunization Day in a rural block of India.

    Science.gov (United States)

    Pakhare, Abhijit P; Bali, Surya; Pawar, Radhakishan B; Lokhande, Ganesh S

    2014-01-01

    India was certified polio free on 27 March 2014. Supplementary immunization activities, in the form of national immunization days, is one of the core strategies for eradication, where oral polio vaccine is administered to children aged under 5 years throughout the country. Oral polio vaccine is heat sensitive and requires maintenance of a stringent cold chain. Therefore, vaccine carriers with ice packs are used in the Pulse Polio Immunization (PPI) programme. This study assessed whether the cold chain is maintained during National Immunization Day in Beed district. A cross-sectional study was conducted at six randomly selected booths, one each from six primary health centres in Georai block of Beed district in Maharashtra. Electronic data loggers, configured to measure half-hourly temperatures, were kept in vaccine carriers throughout the day of PPI. The vaccine carrier temperature was below 8 °C at all six booths; minimum temperature recorded was -9.5 °C, while the maximum was 4.5 °C. The vaccine vial monitor did not reach discard point in any booth. A vaccine carrier with four ice packs very effectively maintains the cold chain required for oral polio vaccine.

  1. Preventive maintenance and reliability-centered maintenance

    International Nuclear Information System (INIS)

    Anderson, J.G.

    1989-01-01

    In the recent past, the primary function of the preventive maintenance program at a nuclear power plant was to maintain the operability and reliability of the plant. Reducing overall maintenance costs by performing effective preventive maintenance, instead of more costly and disruptive corrective maintenance, instead of more costly and disruptive corrective maintenance, was a secondary consideration. In today's operating environment, the preventive maintenance program must meet the test of cost-effectiveness as well as many new standards for performance that are being required by rate regulators. The preventive maintenance program must be able to withstand the challenge of independent audit to a new standard of technical adequacy and compliance with recommendations from component vendors. In this new environment, the standard that is being applied at the San Onofre nuclear generating station (SONGS) is that the preventive maintenance program must meet the test of cost-effectiveness, improve equipment performance, support increased plant availability, and (a) literally implement the recommendations of the vendor, (b) provide other compensation for the vendor recommendation, or (c) provide technical justification for the deviation. The subject of this paper is the way that reliability-centered maintenance (RCM) is helping SONGS meet these challenges

  2. Remote-Handled Transuranic Waste Content Codes (RH-Trucon)

    International Nuclear Information System (INIS)

    2006-01-01

    The Remote-Handled Transuranic (RH-TRU) Content Codes (RH-TRUCON) document describes the inventory of RH-TRU waste within the transportation parameters specified by the Remote-Handled Transuranic Waste Authorized Methods for Payload Control (RH-TRAMPAC). The RH-TRAMPAC defines the allowable payload for the RH-TRU 72-B. This document is a catalog of RH-TRU 72-B authorized contents by site. A content code is defined by the following components: (1) A two-letter site abbreviation that designates the physical location of the generated/stored waste (e.g., ID for Idaho National Laboratory [INL]). The site-specific letter designations for each of the sites are provided in Table 1. (2) A three-digit code that designates the physical and chemical form of the waste (e.g., content code 317 denotes TRU Metal Waste). For RH-TRU waste to be transported in the RH-TRU 72-B, the first number of this three-digit code is ''3''. The second and third numbers of the three-digit code describe the physical and chemical form of the waste. Table 2 provides a brief description of each generic code. Content codes are further defined as subcodes by an alpha trailer after the three-digit code to allow segregation of wastes that differ in one or more parameter(s). For example, the alpha trailers of the subcodes ID 322A and ID 322B may be used to differentiate between waste packaging configurations. As detailed in the RH-TRAMPAC, compliance with flammable gas limits may be demonstrated through the evaluation of compliance with either a decay heat limit or flammable gas generation rate (FGGR) limit per container specified in approved content codes. As applicable, if a container meets the watt*year criteria specified by the RH-TRAMPAC, the decay heat limits based on the dose-dependent G value may be used as specified in an approved content code. If a site implements the administrative controls outlined in the RH-TRAMPAC and Appendix 2.4 of the RH-TRU Payload Appendices, the decay heat or FGGR

  3. Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I.

    Science.gov (United States)

    Wang, Raymond Y; Aminian, Afshin; McEntee, Michael F; Kan, Shih-Hsin; Simonaro, Calogera M; Lamanna, William C; Lawrence, Roger; Ellinwood, N Matthew; Guerra, Catalina; Le, Steven Q; Dickson, Patricia I; Esko, Jeffrey D

    2014-08-01

    abolished in rhIDUA-treated joints only. Intra-articular rhIDUA is well-tolerated and safe in the canine MPS I animal model. Qualitative and quantitative assessments indicate that IA-rhIDUA successfully reduces tissue and cellular GAG storage in synovium and articular cartilage, including cartilage deep to the articular surface, and eliminates inflammatory macrophages from synovial tissue. The MPS I canine IA-rhIDUA results suggest that clinical studies should be performed to determine if IA-rhIDUA is a viable approach to ameliorating refractory orthopedic disease in human MPS I. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. Waste Isolation Pilot Plant simulated RH TRU waste experiments: Data and interpretation pilot

    International Nuclear Information System (INIS)

    Molecke, M.A.; Argueello, G.J.; Beraun, R.

    1993-04-01

    The simulated, i.e., nonradioactive remote-handled transuranic waste (RH TRU) experiments being conducted underground in the Waste Isolation Pilot Plant (WIPP) were emplaced in mid-1986 and have been in heated test operation since 9/23/86. These experiments involve the in situ, waste package performance testing of eight full-size, reference RH TRU containers emplaced in horizontal, unlined test holes in the rock salt ribs (walls) of WIPP Room T. All of the test containers have internal electrical heaters; four of the test emplacements were filled with bentonite and silica sand backfill materials. We designed test conditions to be ''near-reference'' with respect to anticipated thermal outputs of RH TRU canisters and their geometrical spacing or layout in WIPP repository rooms, with RH TRU waste reference conditions current as of the start date of this test program. We also conducted some thermal overtest evaluations. This paper provides a: detailed test overview; comprehensive data update for the first 5 years of test operations; summary of experiment observations; initial data interpretations; and, several status; experimental objectives -- how these tests support WIPP TRU waste acceptance, performance assessment studies, underground operations, and the overall WIPP mission; and, in situ performance evaluations of RH TRU waste package materials plus design details and options. We provide instrument data and results for in situ waste container and borehole temperatures, pressures exerted on test containers through the backfill materials, and vertical and horizontal borehole-closure measurements and rates. The effects of heat on borehole closure, fracturing, and near-field materials (metals, backfills, rock salt, and intruding brine) interactions were closely monitored and are summarized, as are assorted test observations. Predictive 3-dimensional thermal and structural modeling studies of borehole and room closures and temperature fields were also performed

  5. Advanced maintenance research programs

    International Nuclear Information System (INIS)

    Marston, T.U.; Gelhaus, F.; Burke, R.

    1985-01-01

    The purpose of this paper is to provide the reader with an idea of the advanced maintenance research program at the Electric Power Research Institute (EPRI). A brief description of the maintenance-related activities is provided as a foundation for the advanced maintenance research projects. The projects can be divided into maintenance planning, preventive maintenance program development and implementation, predictive (or conditional) maintenance, and innovative maintenance techniques. The projects include hardware and software development, human factors considerations, and technology promotion and implementation. The advanced concepts include: the incorporation of artificial intelligence into outage planning; turbine and pump maintenance; rotating equipment monitoring and diagnostics with the aid of expert systems; and the development of mobile robots for nuclear power plant maintenance

  6. Selective interactions among Rh, ABO, and sex ratio of newborns.

    Science.gov (United States)

    Valenzuela, C Y; Walton, R

    1985-01-01

    The hypothesis that the Rh and ABO blood systems behave like the HLA system in relation to mother-conception tolerance-rejection mechanisms was tested in 25,501 mother-infant pairs. According to this hypothesis, heterozygotes carrying a paternal gene that is not present in their mothers should be better tolerated than homozygotes. Significantly more BO infants born to AO mothers. AO infants born to BO mothers, Rh(+) heterozygotes born to Rh(-) mothers, and less significantly AO infants born to OO mothers confirm the hypothesis. Fewer homozygotes occurred in Rh(-) infants born to Rh(+) mothers and in O infants born to non-O mothers. Deviations from the Hardy-Weinberg equilibrium found in the ABO system were modified by the Rh and sex of the infant. These data strongly support the hypothesis that at least two feto-maternal systems influence the destiny of pregnancies: the classical known incompatibility system which operates late in pregnancy and a new one which is based on the induction of maternal tolerance early in pregnancy: maternal tolerance seems to be better elicited by heterozygous eggs or embryos carrying a gene not present in the mother. The data also support the hypothesis that the sex ratio is influenced by feto-maternal tolerance-rejection mechanisms associated with the ABO and Rh systems.

  7. Practice Bulletin No. 181 Summary: Prevention of Rh D Alloimmunization.

    Science.gov (United States)

    2017-08-01

    Advances in the prevention and treatment of Rh D alloimmunization have been one of the great success stories of modern obstetrics. There is wide variation in prevalence rates of Rh D-negative individuals between regions, for example from 5% in India to 15% in North America (1). However, high birth rates in low prevalence areas means Rh hemolytic disease of the newborn is still an important cause of morbidity and mortality in countries without prophylaxis programs (1). In such countries, 14% of affected fetuses are stillborn and one half of live born infants suffer neonatal death or brain injury (1). The routine use of Rh D immune globulin is responsible for the reduced rate of red cell alloimmunization in more economically developed countries. First introduced in the 1970s, the postpartum administration of Rh D immune globulin reduced the rate of alloimmunization in at-risk pregnancies from approximately 13-16% to approximately 0.5-1.8% (2, 3). The risk was further reduced to 0.14-0.2% with the addition of routine antepartum administration (2, 3). Despite considerable proof of efficacy, there are still a large number of cases of Rh D alloimmunization because of failure to follow established protocols. In addition, there are new data to help guide management, especially with regard to weak D phenotype women. The purpose of this document is to provide evidence-based guidance for the management of patients at risk of Rh D alloimmunization.

  8. Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.

    Science.gov (United States)

    2017-08-01

    Advances in the prevention and treatment of Rh D alloimmunization have been one of the great success stories of modern obstetrics. There is wide variation in prevalence rates of Rh D-negative individuals between regions, for example from 5% in India to 15% in North America (1). However, high birth rates in low prevalence areas means Rh hemolytic disease of the newborn is still an important cause of morbidity and mortality in countries without prophylaxis programs (1). In such countries, 14% of affected fetuses are stillborn and one half of live born infants suffer neonatal death or brain injury (1). The routine use of Rh D immune globulin is responsible for the reduced rate of red cell alloimmunization in more economically developed countries. First introduced in the 1970s, the postpartum administration of Rh D immune globulin reduced the rate of alloimmunization in at-risk pregnancies from approximately 13-16% to approximately 0.5-1.8% (2, 3). The risk was further reduced to 0.14-0.2% with the addition of routine antepartum administration (2, 3). Despite considerable proof of efficacy, there are still a large number of cases of Rh D alloimmunization because of failure to follow established protocols. In addition, there are new data to help guide management, especially with regard to weak D phenotype women. The purpose of this document is to provide evidence-based guidance for the management of patients at risk of Rh D alloimmunization.

  9. Hydroformylation of 1-Hexene over Rh/Nano-Oxide Catalysts

    Directory of Open Access Journals (Sweden)

    Sari Suvanto

    2013-03-01

    Full Text Available The effect of nanostructured supports on the activity of Rh catalysts was studied by comparing the catalytic performance of nano- and bulk-oxide supported Rh/ZnO, Rh/SiO2 and Rh/TiO2 systems in 1-hexene hydroformylation. The highest activity with 100% total conversion and 96% yield of aldehydes was obtained with the Rh/nano-ZnO catalyst. The Rh/nano-ZnO catalyst was found to be more stable and active than the corresponding rhodium catalyst supported on bulk ZnO. The favorable morphology of Rh/nano-ZnO particles led to an increased metal content and an increased number of weak acid sites compared to the bulk ZnO supported catalysts. Both these factors favored the improved catalytic performance. Improvements of catalytic properties were obtained also with the nano-SiO2 and nano-TiO2 supports in comparison with the bulk supports. All of the catalysts were characterized by scanning electron microscope (SEM, inductively coupled plasma mass spectrometry (ICP-MS, BET, powder X-ray diffraction (PXRD and NH3- temperature-programmed desorption (TPD.

  10. A Methodology for Modeling Nuclear Power Plant Passive Component Aging in Probabilistic Risk Assessment under the Impact of Operating Conditions, Surveillance and Maintenance Activities

    Science.gov (United States)

    Guler Yigitoglu, Askin

    In the context of long operation of nuclear power plants (NPPs) (i.e., 60-80 years, and beyond), investigation of the aging of passive systems, structures and components (SSCs) is important to assess safety margins and to decide on reactor life extension as indicated within the U.S. Department of Energy (DOE) Light Water Reactor Sustainability (LWRS) Program. In the traditional probabilistic risk assessment (PRA) methodology, evaluating the potential significance of aging of passive SSCs on plant risk is challenging. Although passive SSC failure rates can be added as initiating event frequencies or basic event failure rates in the traditional event-tree/fault-tree methodology, these failure rates are generally based on generic plant failure data which means that the true state of a specific plant is not reflected in a realistic manner on aging effects. Dynamic PRA methodologies have gained attention recently due to their capability to account for the plant state and thus address the difficulties in the traditional PRA modeling of aging effects of passive components using physics-based models (and also in the modeling of digital instrumentation and control systems). Physics-based models can capture the impact of complex aging processes (e.g., fatigue, stress corrosion cracking, flow-accelerated corrosion, etc.) on SSCs and can be utilized to estimate passive SSC failure rates using realistic NPP data from reactor simulation, as well as considering effects of surveillance and maintenance activities. The objectives of this dissertation are twofold: The development of a methodology for the incorporation of aging modeling of passive SSC into a reactor simulation environment to provide a framework for evaluation of their risk contribution in both the dynamic and traditional PRA; and the demonstration of the methodology through its application to pressurizer surge line pipe weld and steam generator tubes in commercial nuclear power plants. In the proposed methodology, a

  11. In vitro evidence of glucose-induced toxicity in GnRH secreting neurons: high glucose concentrations influence GnRH secretion, impair cell viability, and induce apoptosis in the GT1-1 neuronal cell line.

    Science.gov (United States)

    Pal, Lubna; Chu, Hsiao-Pai; Shu, Jun; Topalli, Ilir; Santoro, Nanette; Karkanias, George

    2007-10-01

    To evaluate for direct toxic effects of high glucose concentrations on cellular physiology in GnRH secreting immortalized GT1-1 neurons. Prospective experimental design. In vitro experimental model using a cell culture system. GT1-1 cells were cultured in replicates in media with two different glucose concentrations (450 mg/dL and 100 mg/dL, respectively) for varying time intervals (24, 48, and 72 hours). Effects of glucose concentrations on GnRH secretion by the GT1-1 neurons were evaluated using a static culture model. Cell viability, cellular apoptosis, and cell cycle events in GT1-1 neurons maintained in two different glucose concentrations were assessed by flow cytometry (fluorescence-activated cell sorter) using Annexin V-PI staining. Adverse influences of high glucose concentrations on GnRH secretion and cell viability were noted in cultures maintained in high glucose concentration (450 mg/dL) culture medium for varying time intervals. A significantly higher percentage of cells maintained in high glucose concentration medium demonstrated evidence of apoptosis by a fluorescence-activated cell sorter. We provide in vitro evidence of glucose-induced cellular toxicity in GnRH secreting GT1-1 neurons. Significant alterations in GnRH secretion, reduced cell viability, and a higher percentage of apoptotic cells were observed in GT1-1 cells maintained in high (450 mg/dL) compared with low (100 mg/dL) glucose concentration culture medium.

  12. RhD Specific Antibodies Are Not Detectable in HLA-DRB11501* Mice Challenged with Human RhD Positive Erythrocytes

    Directory of Open Access Journals (Sweden)

    Lidice Bernardo

    2014-01-01

    Full Text Available The ability to study the immune response to the RhD antigen in the prevention of hemolytic disease of the fetus and newborn has been hampered by the lack of a mouse model of RhD immunization. However, the ability of transgenic mice expressing human HLA DRB11501* to respond to immunization with purified RhD has allowed this question to be revisited. In this work we aimed at inducing anti-RhD antibodies by administering human RhD+ RBCs to mice transgenic for the human HLA DRB11501* as well as to several standard inbred and outbred laboratory strains including C57BL/6, DBA1/J, CFW(SW, CD1(ICR, and NSA(CF-1. DRB11501* mice were additionally immunized with putative extracellular immunogenic RhD peptides. DRB11501* mice immunized with RhD+ erythrocytes developed an erythrocyte-reactive antibody response. Antibodies specific for RhD could not however be detected by flow cytometry. Despite this, DRB11501* mice were capable of recognizing immunogenic sequences of Rh as injection with Rh peptides induced antibodies reactive with RhD sequences, consistent with the presence of B cell repertoires capable of recognizing RhD. We conclude that while HLA DRB11501* transgenic mice may have the capability of responding to immunogenic sequences within RhD, an immune response to human RBC expressing RhD is not directly observed.

  13. Maintenance work management system

    International Nuclear Information System (INIS)

    Kanai, T.; Takahashi, Y.; Takahashi, K.; Nishino, M.; Takeshige, R.

    2000-01-01

    The maintenance work management system supports the efficient drawing up of various documents for the maintenance work at nuclear power stations and the speeding up of the permission procedure. In addition, it improves the quality assurance of the safety and reliability of the maintenance work. Key merits of the system are: 1. Efficiently drawing up various documents for the maintenance work by using the stored data for the previous maintenance work and the pipe and instrument diagram (P and ID) data. 2. Supporting the management work for the completion of maintenance work safety by using the isolation information stored on the computer system. 3. Speeding up the permission procedure by electronic mail and electronic permission. 4. Displaying additional information such as the specifications of equipment, maintenance result, and maintenance plan by linking up with the database of another system. 5. Reducing the cost of hardware devices by using client/server network configurations of personal computers and a personal computer server. (author)

  14. Unsurfaced Road Maintenance Management

    Science.gov (United States)

    1992-12-01

    This draft manual describes an unsurfaced road maintenance management system for use on military installations. This system is available in either a manual or computerized mode (Micro PAVER). The maintenance standards prescribed should protect Govern...

  15. Winter maintenance performance measure.

    Science.gov (United States)

    2016-01-01

    The Winter Performance Index is a method of quantifying winter storm events and the DOTs response to them. : It is a valuable tool for evaluating the States maintenance practices, performing post-storm analysis, training : maintenance personnel...

  16. The Design, Synthesis and Study of Mixed-Metal Ru,Rh and Os, Rh Complexes with Biologically Relevant Reactivity

    OpenAIRE

    Wang, Jing

    2013-01-01

    A series of mixed-metal bimetallic complexes [(TL)2M(dpp)RhCl2(TL)]3 (M = Ru and Os, terminal ligands (TL) = phen, Ph2phen, Me2phen and bpy, terminal ligands (TL) = phen, bpy and Me2bpy ), which couple one Ru or Os polyazine light absorber (LA) to a cis-RhIIICl2 center through a dpp bridging ligand (BL), were synthesized using a building block method. These are related to previously studied trimetallic systems [{(TL)2M(dpp)2RhCl2]5+, but the bimetallics are synthetically more complex to prepa...

  17. Methanol electro-oxidation and direct methanol fuel cell using Pt/Rh and Pt/Ru/Rh alloy catalysts

    International Nuclear Information System (INIS)

    Choi, Jong-Ho; Park, Kyung-Won; Park, In-Su; Nam, Woo-Hyun; Sung, Yung-Eun

    2004-01-01

    Pt-based binary or ternary catalysts containing Rh for use as anodes in direct methanol fuel cells (DMFC) were synthesized by borohydride reduction method combined with freeze-drying. The resulting catalysts had a specific surface area of approximately 65-75 m 2 /g. X-ray diffraction (XRD) patterns indicated that the catalysts were well alloyed and the average size of alloy catalysts was confirmed by transmission electron microscopy (TEM). The Pt/Rh (2:1) and Pt/Ru/Rh (5:4:1) alloy catalysts showed better catalytic activities for methanol electro-oxidation than Pt or Pt/Ru (1:1), respectively

  18. A Radiation Hardened Housekeeping Slave Node (RH-HKSN) ASIC

    Data.gov (United States)

    National Aeronautics and Space Administration — This projects seeks to continue the development of the Radiation Hardened Housekeeping Slave Node (RH-HKSN) ASIC. The effort has taken parallel paths by implementing...

  19. Comparative frequency and allelic distribution of ABO and Rh (D ...

    African Journals Online (AJOL)

    Gourab Dewan

    2015-02-18

    Feb 18, 2015 ... desh and having borders with India and Myanmar (Fig. 1). It is a hilly area with ..... calculated allelic frequencies for ABO/Rh systems previously. Therefore, allelic .... in backward caste population of Uttar Pradesh, India. Not Sci.

  20. Frequency distribution 0f ABO, RH blood groups and blood ...

    African Journals Online (AJOL)

    user

    2006-11-16

    Nov 16, 2006 ... blood genotypes among the cell biology and genetics students of ... problem in some pregnancies when the mother is Rh – negative and the foetus ... electrophoresis technique was used to determine haemoglobin genotype.

  1. Competence within Maintenance

    OpenAIRE

    Nerland, Annette Smørholm

    2010-01-01

    Maintenance can be a contributing factor to unwanted events, as well as desired events and states. Human competence can be defined as the ability to perform a specific task, action or function successfully, and is therefore a key factor to proper execution of maintenance tasks. Hence,maintenance will have negative consequences if done wrong, and give positive results when done right. The purpose of this report is to study the many aspects of maintenance competence. Endeavoring to improve ...

  2. Ontogenic and sexual differences in pituitary GnRH receptors and intracellular Ca2+ mobilization induced by GnRH.

    Science.gov (United States)

    Lacau-Mengido, I M; González Iglesias, A; Lux-Lantos, V; Libertun, C; Becú-Villalobos, D

    1998-04-01

    The present experiments were designed in order to elucidate the participation of the developing hypophysis in determining the changing sensitivity of gonadotrophins to gonadotropin-releasing hormone (GnRH) during ontogeny in the rat. To that end, we chose two well defined developmental ages that differ markedly in sexual and ontogenic characteristics of hypophyseal sensitivity to GnRH, 15 and 30 d. In order to study sex differences and the role of early sexual organization of the hypothalamus, experiments were carried out in males, females, and neonatally androgenized females (TP females). We evaluated (1) the characteristics of pituitary GnRH receptors, and (2) associated changes in GnRH-induced mobilization of intracellular Ca2+ (a second messenger involved in gonadotropins exocytosis). We measured binding characteristics of the GnRH analog D-Ser(TBu)6-des-Gly10-GnRH ethylamide in pituitary homogenates. We found that Kds did not vary among the different sex groups. Total number and concentration of receptors decreased in the female rat from 15-30 d of age, whereas in the male and TP female, receptors/pituitary increased, and the concentration/mg tissue did not change. Also, at 30 days of age, males presented higher content and concentration of receptors than females, and higher content than TP females. In order to evaluate if developmental and sexual differences in pituitary sensitivity to GnRH might be expressed through variations in the intracellular Ca2+ signal, we studied the mobilization of intracellular Ca2+ induced by GnRH (1 x 10(-8) to 1 x 10(-11) M) in a suspension of dispersed pituitary cells in the six groups. In cells from 15-d-old females, Ca2+ response was greater than in 30-d-old females at the doses of 10(-8) to 10(-10) M, indicating that in the infantile female rat activation of highly concentrated GnRH receptors is reflected in an increase in signal transduction mediated by Ca2+. In males and in female rats androgenized at birth, there was also

  3. Asphalt in Pavement Maintenance.

    Science.gov (United States)

    Asphalt Inst., College Park, MD.

    Maintenance methods that can be used equally well in all regions of the country have been developed for the use of asphalt in pavement maintenance. Specific information covering methods, equipment and terminology that applies to the use of asphalt in the maintenance of all types of pavement structures, including shoulders, is provided. In many…

  4. Optimization of surface maintenance

    International Nuclear Information System (INIS)

    Oeverland, E.

    1990-01-01

    The present conference paper deals with methods of optimizing the surface maintenance of steel-made offshore installations. The paper aims at identifying important approaches to the problems regarding the long-range planning of an economical and cost effective maintenance program. The methods of optimization are based on the obtained experiences from the maintenance of installations on the Norwegian continental shelf. 3 figs

  5. Dukovany NPP maintenance management

    International Nuclear Information System (INIS)

    Siegel, F.

    2005-01-01

    Maintenance planning and management for the technological equipment of the Dukovany NPP are described. A Maintenance Control and Evaluation System has been developed and is in use to help manage the complex maintenance issue. Practical examples of outputs of the System, with a comprehensive use of the cost, reliability and safety related data, are presented. (author)

  6. Regulation versus modulation in GnRH receptor function

    International Nuclear Information System (INIS)

    Zolman, J.C.; Theodoropoulos, T.J.

    1985-01-01

    Serum luteinizing hormone (LH) concentration after exposure to gonadotropin-releasing hormone (GnRH) indicates that an instantaneous increase occurs in the rate of release of LH directly from the anterior pituitary, as measured dynamically during superfusion in vitro. On the other hand, estradiol-17 beta (E2) alone shows no such instantaneous effect on LH release rate (at least for the first four hours), in either physiologic or pharmacologic concentrations. At the same time, brief (ten to 30 minute) exposure of isolated anterior pituitary plasma membranes to physiologic concentrations of E2 significantly alters the binding of a fully biologically active 125 I-GnRH to its plasma membrane receptor protein. In order to characterize the effect of E2 on GnRH binding further, dispersed bovine anterior pituitary cells were preincubated for six hours in the presence or absence of physiologic concentrations of E2 (10(-10)M). Following preincubation in the presence of E2, the cell suspension was incubated for 30 minutes with physiologic concentrations (5 x 10(-11) - 5 x 10(-10)M) of a fully biologically active 125 I-GnRH. The treatment, at least, doubled the number of biologically important high affinity GnRH binding sites (Kd's . 7.5 x -10(-11) - 4.5 x 10(-10)M), and changed the binding capacity of some of the binding sites up to three fold, which altered the cooperativity of GnRH-receptor interaction. Thus, the interaction of E2 with GnRH at the level of GnRH receptor is mandatory for the short-term pituitary effect of E2 on LH release in vitro and in vivo

  7. Reorientation precession measurements of quadrupole moments in 103Rh

    International Nuclear Information System (INIS)

    Gelberg, A.; Herskind, B.; Kalish, R.; Neiman, M.

    1976-01-01

    The quadrupole moments of the 3/2 - and 5/2 - states in 103 Rh have been determined by measuring the precession of the gamma-ray angular distribution following Coulomb excitation; 16 O and 32 S beams have been used. The structure of the negative-parity states in 103 Rh is found to be in agreement with the model of Arima and Iachello. (orig.) [de

  8. The Rh allele frequencies in Gaza city in Palestine

    Directory of Open Access Journals (Sweden)

    Skaik Younis

    2011-01-01

    Full Text Available Background: The Rh blood group system is the second most clinically significant blood group system. It includes 49 antigens, but only five (D, C, E, c and e are the most routinely identified due to their unique relation to hemolytic disease of the newborn (HDN and transfusion reactions. Frequency of the Rh alleles showed variation, with regard to race and ethnic. Objectives: The purpose of the study was to document the Rh alleles′ frequencies amongst males (M and females (F in Gaza city in Palestine. Materials and Methods: Two hundred and thirty-two blood samples (110 M and 122 F were tested against monoclonal IgM anti-C,anti-c, anti-E, anti-e and a blend of monoclonal/polyclonal IgM/IgG anti-D. The expected Rh phenotypes were calculated using gene counting method. Results: The most frequent Rh antigen in the total sample was e, while the least frequent was E.The order of the combined Rh allele frequencies in both M and F was CDe > cDe > cde > CdE > cDE > Cde > CDE. A significant difference was reported between M and F regarding the phenotypic frequencies (P < 0.05. However, no significance (P > 0.05 was reported with reference to the observed and expected Rh phenotypic frequencies in either M or F students. Conclusion: It was concluded that the Rh antigens, alleles and phenotypes in Gaza city have unique frequencies, which may be of importance to the Blood Transfusion Center in Gaza city and anthropology.

  9. Assessing the co-benefits of greenhouse gas reduction: Health benefits of particulate matter related inspection and maintenance programs in Bangkok, Thailand

    International Nuclear Information System (INIS)

    Li, Ying; Crawford-Brown, Douglas J.

    2011-01-01

    Since the 1990s, the capital city of Thailand, Bangkok has been suffering from severe ambient particulate matter (PM) pollution mainly attributable to its wide use of diesel-fueled vehicles and motorcycles with poor emission performance. While the Thai government strives to reduce emissions from transportation through enforcing policy measures, the link between specific control policies and associated health impacts is inadequately studied. This link is especially important in exploring the co-benefits of greenhouse gas emissions reductions, which often brings reduction in other pollutants such as PM. This paper quantifies the health benefits potentially achieved by the new PM-related I/M programs targeting all diesel vehicles and motorcycles in the Bangkok Metropolitan Area (BMA). The benefits are estimated by using a framework that integrates policy scenario development, exposure assessment, exposure-response assessment and economic valuation. The results indicate that the total health damage due to the year 2000 PM emissions from vehicles in the BMA was equivalent to 2.4% of Thailand's GDP. Under the business-as-usual (BAU) scenario, total vehicular PM emissions in the BMA will increase considerably over time due to the rapid growth in vehicle population, even if the fleet average emission rates are projected to decrease over time as the result of participation of Thailand in post-Copenhagen climate change strategies. By 2015, the total health damage is estimated to increase by 2.5 times relative to the year 2000. However, control policies targeting PM emissions from automobiles, such as the PM-oriented I/M programs, could yield substantial health benefits relative to the BAU scenario, and serve as co-benefits of greenhouse gas control strategies. Despite uncertainty associated with the key assumptions used to estimate benefits, we find that with a high level confidence, the I/M programs will produce health benefits whose economic impacts considerably outweigh

  10. Maintenance evaluation using risk based criteria

    International Nuclear Information System (INIS)

    Torres Valle, A.

    1996-01-01

    The maintenance evaluation is currently performed by using economic and, in some case, technical equipment failure criteria, however this is done to a specific equipment level. In general, when statistics are used the analysis for maintenance optimization are made isolated and whit a post mortem character; The integration provided by mean of Probabilistic Safety assessment (PSA) together with the possibilities of its applications, allow for evaluation of maintenance on the basis of broader scope criteria in regard to those traditionally used. The evaluate maintenance using risk based criteria, is necessary to follow a dynamic and systematic approach, in studying the maintenance strategy, to allow for updating the initial probabilistic models, for including operational changes that often take place during operation of complex facilities. This paper proposes a dynamic evaluation system of maintenance task. The system is illustrated by means of a practical example

  11. Upgrade of maintenance technologies of Nuclear Power Plants

    International Nuclear Information System (INIS)

    Kamada, Kazuaki

    2005-01-01

    In order to enhance long-term safe and stable operation of Ikata Nuclear Power Plants (NPPs) in more efficient way, maintenance technology upgrade project was started aiming at establishment of simplified and efficient self-maintenance system with affiliated companies. Maintenance technique and supervisor qualification system was introduced after improvement and reinforcement of personnel education and training. Reflecting investigation of maintenance activities of US NPPs and productivity improvement in other industries, preventive maintenance optimization project had been performed such as introduction of key performance indicator (KPI), new system incorporating reliability-centered maintenance (RCM) and condition-based maintenance (CBM), and on-line monitoring and maintenance (OLM) based on risk assessment. Enterprise asset management (EAM) to establish information data base and total productive maintenance (TPM) action for every personnel to participate in self-maintenance was also introduced. (T. Tanaka)

  12. A first-principles study of the possible magnetism of Rh in the Cu/Rh/Cu(001) system

    CERN Document Server

    Jang, Y R; Chang, C S; Cho, L H; Lee, J I

    1999-01-01

    Possible 4d magnetism of a Rh monolayer in a Cu/Rh/Cu(001) system is investigated using the full-potential linearized augmented-plane-wave (FLAPW) energy band method based on the local-spin-density approximation (LSDA). We have calculated the total energy of the Cu/Rh/Cu(001) system and have found that the Rh monolayer is ferromagnetic (FM) with a tiny magnetic moment. However, the total energy difference between the ferromagnetic and the paramagnetic states is found to be very small, and thus which state can be realized at room temperature is uncertain. The calculated charge densities and layer-projected density of states (LDOS) are presented and discussed in relation to the magnetic properties.

  13. EPR design for maintenance

    International Nuclear Information System (INIS)

    Krugmann, U.

    1998-01-01

    Preventive maintenance is very important in achieving high plant availability. For the European Pressurized Reactor (EPR) preventive maintenance has been carefully addressed in the design stage. This is particularly necessary because of the traditionally different maintenance strategies employed in France and Germany. This paper emphasizes the following features introduced in the ERP design to minimize the duration of the refueling outage: (1) containment accessibility during power operation; (2) overall plant layout to facilitate inspections and maintenances within the containment; and (3) safety system design for enabling preventive maintenance during power operation. (author)

  14. Modern electronic maintenance principles

    CERN Document Server

    Garland, DJ

    2013-01-01

    Modern Electronic Maintenance Principles reviews the principles of maintaining modern, complex electronic equipment, with emphasis on preventive and corrective maintenance. Unfamiliar subjects such as the half-split method of fault location, functional diagrams, and fault finding guides are explained. This book consists of 12 chapters and begins by stressing the need for maintenance principles and discussing the problem of complexity as well as the requirements for a maintenance technician. The next chapter deals with the connection between reliability and maintenance and defines the terms fai

  15. Managing nuclear maintenance

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    For utilities operating nuclear powerplants, the rules of the game continue to change. Conflicting regulatory pressures and a tougher competitive environment will make management's job more complicated and difficult in the 1990s. Dealing with these pressures successfully requires greater attention to maintenance effectiveness. Utilities can help shape their future environment by developing a well-planned strategy to guide their actions. Parts of the strategy that are discussed include developing a sound maintenance philosophy, selecting a service company, radiation exposure, and managing spare parts. This article also addresses the Swedish experience in maintenance, German philosophy regarding maintenance and the current maintenance practices of the Electricite de France

  16. AIRCRAFT MAINTENANCE HANGAR

    Directory of Open Access Journals (Sweden)

    GEAMBASU Gabriel George

    2017-05-01

    Full Text Available The paper presents the maintenance process that is done on an airplane, at a certain period of time, or after a number of flight hours or cycles and describes the checks performed behind each inspection. The first part of research describes the aircraft maintenance process that has to be done after an updated maintenance manual according with aircraft type, followed by a short introduction about maintenance hangar. The second part of the paper presents a hangar design with a foldable roof and walls, which can be folded or extended, over an airplane when a maintenance process is done, or depending on weather condition.

  17. Inspection of licensee - Maintenance programme and activities

    International Nuclear Information System (INIS)

    2013-01-01

    An effective maintenance programme is critical to sustained safe and reliable operation of nuclear power plants. The Working Group on Inspection Practices (WGIP) concluded that when a licensee has an effective maintenance programme, the overall operating safety of the plant is improved and the protection of public health and safety enhanced. All Regulatory Bodies (RB) consider maintenance to be an important area for oversight. Although a variety of inspection practices are being used; RB are actively monitoring licensee performance. Specifically the following conclusions were reached and commendable practices identified: - Maintenance oversight by regulators appears to be in a stable continuous improvement state. Most regulators are executing inspection oversight based on an existing regulatory framework. - The performance of a licensee's maintenance programme is recognized as important part of maintaining nuclear safety. The result of the maintenance program assessment is included in the overall performance assessment of a license. - Maintenance inspection activities are recognized as an important part of the regulatory oversight process. Inspection activities are based on the safety significance and nature of work being performed by the licensee. - The effectiveness of the maintenance inspection activities is recognized to rely on properly qualified inspectors; who are adequately supported by specialists. Training and qualification of inspectors should be based on how the RB reviews and inspects licensee maintenance programmes. - Reporting requirements are identified to provide information on the licensees maintenance programme, and to help guide inspection activities. - Performance Indicators are recognized as a useful tool for helping focus regulatory activities. Basic PI are identified and tracked by the RB, and use of PI by the licensee is monitored. - Inspections are designed to confirm that the licensee is planning and scheduling maintenance with due

  18. Estimating Maintenance Cost for Web Applications

    Directory of Open Access Journals (Sweden)

    Ion IVAN

    2016-01-01

    Full Text Available The current paper tackles the issue of determining a method for estimating maintenance costs for web applications. The current state of research in the field of web application maintenance is summarized and leading theories and results are highlighted. The cost of web maintenance is determined by the number of man-hours invested in maintenance tasks. Web maintenance tasks are categorized into content maintenance and technical maintenance. Research is centered on analyzing technical maintenance tasks. The research hypothesis is formulated on the assumption that the number of man-hours invested in maintenance tasks can be assessed based on the web application’s user interaction level, complexity and content update effort. Data regarding the costs of maintenance tasks is collected from 24 maintenance projects implemented by a web development company that tackles a wide area of web applications. Homogeneity and diversity of collected data is submitted for debate by presenting a sample of the data and depicting the overall size and comprehensive nature of the entire dataset. A set of metrics dedicated to estimating maintenance costs in web applications is defined based on conclusions formulated by analyzing the collected data and the theories and practices dominating the current state of research. Metrics are validated with regards to the initial research hypothesis. Research hypothesis are validated and conclusions are formulated on the topic of estimating the maintenance cost of web applications. The limits of the research process which represented the basis for the current paper are enunciated. Future research topics are submitted for debate.

  19. Successful synthesis and thermal stability of immiscible metal Au-Rh, Au-Ir andAu-Ir-Rh nanoalloys

    Science.gov (United States)

    Shubin, Yury; Plyusnin, Pavel; Sharafutdinov, Marat; Makotchenko, Evgenia; Korenev, Sergey

    2017-05-01

    We successfully prepared face-centred cubic nanoalloys in systems of Au-Ir, Au-Rh and Au-Ir-Rh, with large bulk miscibility gaps, in one-run reactions under thermal decomposition of specially synthesised single-source precursors, namely, [AuEn2][Ir(NO2)6], [AuEn2][Ir(NO2)6] х [Rh(NO2)6]1-х and [AuEn2][Rh(NO2)6]. The precursors employed contain all desired metals ‘mixed’ at the atomic level, thus providing significant advantages for obtaining alloys. The observations using high-resolution transmission electron microscopy show that the nanoalloy structures are composed of well-dispersed aggregates of crystalline domains with a mean size of 5 ± 3 nm. Еnergy dispersive x-ray spectroscopy and x-ray powder diffraction (XRD) measurements confirm the formation of AuIr, AuRh, AuIr0.75Rh0.25, AuIr0.50Rh0.50 and AuIr0.25Rh0.75 metastable solid solutions. In situ high-temperature synchrotron XRD (HTXRD) was used to study the formation mechanism of nanoalloys. The observed transformations are described by the ‘conversion chemistry’ mechanism characterised by the primary development of particles comprising atoms of only one type, followed by a chemical reaction resulting in the final formation of a nanoalloy. The obtained metastable nanoalloys exhibit essential thermal stability. Exposure to 180 °C for 30 h does not cause any dealloying process.

  20. Origins of gonadotropin-releasing hormone (GnRH) in vertebrates: identification of a novel GnRH in a basal vertebrate, the sea lamprey.

    Science.gov (United States)

    Kavanaugh, Scott I; Nozaki, Masumi; Sower, Stacia A

    2008-08-01

    We cloned a cDNA encoding a novel (GnRH), named lamprey GnRH-II, from the sea lamprey, a basal vertebrate. The deduced amino acid sequence of the newly identified lamprey GnRH-II is QHWSHGWFPG. The architecture of the precursor is similar to that reported for other GnRH precursors consisting of a signal peptide, decapeptide, a downstream processing site, and a GnRH-associated peptide; however, the gene for lamprey GnRH-II does not have introns in comparison with the gene organization for all other vertebrate GnRHs. Lamprey GnRH-II precursor transcript was widely expressed in a variety of tissues. In situ hybridization of the brain showed expression and localization of the transcript in the hypothalamus, medulla, and olfactory regions, whereas immunohistochemistry using a specific antiserum showed only GnRH-II cell bodies and processes in the preoptic nucleus/hypothalamus areas. Lamprey GnRH-II was shown to stimulate the hypothalamic-pituitary axis using in vivo and in vitro studies. Lamprey GnRH-II was also shown to activate the inositol phosphate signaling system in COS-7 cells transiently transfected with the lamprey GnRH receptor. These studies provide evidence for a novel lamprey GnRH that has a role as a third hypothalamic GnRH. In summary, the newly discovered lamprey GnRH-II offers a new paradigm of the origin of the vertebrate GnRH family. We hypothesize that due to a genome/gene duplication event, an ancestral gene gave rise to two lineages of GnRHs: the gnathostome GnRH and lamprey GnRH-II.

  1. Maintenance management systems

    International Nuclear Information System (INIS)

    Rohan, M. de

    1989-01-01

    This paper is concerned principally with Maintenance Management systems and their effective introduction into organisations. Maintenance improvement is basically a problem of managing the maintenance department in the broadest sense. Improvement does not only lie in the area of special techniques, systems or procedures; although they are valuable tools, but rather in a balanced attack, carefully guided by management. Over recent years, maintenance systems have received the major emphasis and in many instances the selection of the system has become a pre-occupation, whereas the importance of each maintenance function must be recognised and good management practices applied to all maintenance activities. The ingredients for success in the implementation of maintenance management systems are summarised as: having a management committee, clear objectives, project approach using project management techniques and an enthusiastic leader, user managed and data processing supported project, realistic budget and an understanding of the financial audit requirements. (author)

  2. Knowledge based maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Sturm, A [Hamburgische Electacitaets-Werke AG Hamburg (Germany)

    1998-12-31

    The establishment of maintenance strategies is of crucial significance for the reliability of a plant and the economic efficiency of maintenance measures. Knowledge about the condition of components and plants from the technical and business management point of view therefore becomes one of the fundamental questions and the key to efficient management and maintenance. A new way to determine the maintenance strategy can be called: Knowledge Based Maintenance. A simple method for determining strategies while taking the technical condition of the components of the production process into account to the greatest possible degree which can be shown. A software with an algorithm for Knowledge Based Maintenance leads the user during complex work to the determination of maintenance strategies for this complex plant components. (orig.)

  3. Knowledge based maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Sturm, A. [Hamburgische Electacitaets-Werke AG Hamburg (Germany)

    1997-12-31

    The establishment of maintenance strategies is of crucial significance for the reliability of a plant and the economic efficiency of maintenance measures. Knowledge about the condition of components and plants from the technical and business management point of view therefore becomes one of the fundamental questions and the key to efficient management and maintenance. A new way to determine the maintenance strategy can be called: Knowledge Based Maintenance. A simple method for determining strategies while taking the technical condition of the components of the production process into account to the greatest possible degree which can be shown. A software with an algorithm for Knowledge Based Maintenance leads the user during complex work to the determination of maintenance strategies for this complex plant components. (orig.)

  4. Thermal Methane Conversion to Syngas Mediated by Rh1-Doped Aluminum Oxide Cluster Cations RhAl3O4.

    Science.gov (United States)

    Li, Ya-Ke; Yuan, Zhen; Zhao, Yan-Xia; Zhao, Chongyang; Liu, Qing-Yu; Chen, Hui; He, Sheng-Gui

    2016-10-05

    Laser ablation generated RhAl 3 O 4 + heteronuclear metal oxide cluster cations have been mass-selected using a quadrupole mass filter and reacted with CH 4 or CD 4 in a linear ion trap reactor under thermal collision conditions. The reactions have been characterized by state-of-the-art mass spectrometry and quantum chemistry calculations. The RhAl 3 O 4 + cluster can activate four C-H bonds of a methane molecule and convert methane to syngas, an important intermediate product in methane conversion to value-added chemicals. The Rh atom is the active site for activation of the C-H bonds of methane. The high electron-withdrawing capability of Rh atom is the driving force to promote the conversion of methane to syngas. The polarity of Rh oxidation state is changed from positive to negative after the reaction. This study has provided the first example of methane conversion to syngas by heteronuclear metal oxide clusters under thermal collision conditions. Furthermore, the molecular level origin has been revealed for the condensed-phase experimental observation that trace amounts of Rh can promote the participation of lattice oxygen of chemically very inert support (Al 2 O 3 ) to oxidize methane to carbon monoxide.

  5. The European contribution to the ITER Remote Maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Damiani, C., E-mail: carlo.damiani@f4e.europa.eu [Fusion for Energy, Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Annino, C.; Balagué, S.; Bates, P.; Ceccanti, F.; Di Mascio, T.; Dubus, G.; Esqué, S.; Gonzalez, C.; Lewczanin, M.; Locke, D.; Mont, L.; Olajos, K.; Ranz, R.; Shuff, R.; Puiu, A.; Van Hille, C.; Van Uffelen, M. [Fusion for Energy, Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Choi, C.H.; Friconneau, J.P. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); and others

    2014-10-15

    Highlights: •The article introduces the needs for remote maintenance in ITER. •It also discusses some of the issues related to the cultural transition from tokamaks as plasma physics to nuclear reactors. •It highlights the related cultural change and the implications on plant topology and maintenance. •Then, it presents those remote handling systems that will be procured by Europe. •The article emphasises the need of a major involvement of industries from now on. -- Abstract: For a first-of-a-kind nuclear fusion reactor like ITER, remote maintainability of neutron-activated components is one of the key aspects of plant design and operations, and a fundamental ingredient for the demonstration of long-term viability of fusion as energy source. The European Domestic Agency (EU DA, i.e. Fusion for Energy, F4E) is providing important support to the ITER Organisation (IO) in specifying the functional requirements of the Remote Handling (RH) Procurement Packages (i.e. the subsystems allocated to EU DA belonging to the overall ITER Remote Maintenance Systems IRMS), and in performing design and R and D activities – with the support of national laboratories and industries – in order to define a sound concept for these packages. Furthermore, domestic industries are being involved in the subsequent detailed design, validation, manufacturing and installation activities, in order to actually fulfil our procurement-in-kind obligations. After an introduction to ITER Remote Maintenance, this paper will present status and next stages for the RH systems allocated to EU DA, and will also illustrate complementary aspects related to cross cutting technologies like radiation tolerant components and RH control systems. Finally, the way all these efforts are coordinated will be presented together with the overall implementation scenario and key milestones.

  6. Maintenance proficiency evaluation test bank

    International Nuclear Information System (INIS)

    Maier, Loran

    2003-01-01

    The Maintenance Proficiency Evaluation Test Bank (MPETB) is an Electric Power Research Institute- (EPRJ-) operated, utility-sponsored means of developing, maintaining, and disseminating secure, high-quality written and performance maintenance proficiency tests. EPRTs charter is to ensure that all tests and test items that go into the Test Bank have been validated, screened for reliability, and evaluated to high standards of psychometric excellence. Proficiency tests of maintenance personnel.(mechanics, electricians, and instrumentation and control [I and C] technicians) are most often used to determine if an experienced employee is capable of performing maintenance tasks without further training. Such tests provide objective evidence for decisions to exempt an employee from what, for the employee, is unnecessary training. This leads to considerable savings in training costs and increased productivity because supervisors can assign personnel to tasks at which their competence is proven. The ultimate objective of proficiency evaluation is to ensure that qualified maintenance personnel are available to meet the maintenance requirements of the plant Numerous task-specific MPE tests (both written and performance) have been developed and validated using the EPRI MPE methodology by the utilities participating in the MPETB project A task-specific MPE consists of a multiple-choice written examination and a multi-step performance evaluation that can be used to assess an individual's present knowledge and skill level for a given maintenance task. The MPETB contains MPEs and test items for the mechanical, electrical, and I and C classifications that are readily available to participating utilities. Presently, utilities are placing emphasis on developing MPEs to evaluate outage-related maintenance tasks that demonstrate the competency and qualifications of plant and contractor personnel before the start of outage work. Utilities are also using the MPE methodology and process to

  7. Pilot, randomized study assessing safety, tolerability and efficacy of simplified LPV/r maintenance therapy in HIV patients on the 1 PI-based regimen.

    Science.gov (United States)

    Cahn, Pedro; Montaner, Julio; Junod, Patrice; Patterson, Patricia; Krolewiecki, Alejandro; Andrade-Villanueva, Jaime; Cassetti, Isabel; Sierra-Madero, Juan; Casiró, Arnaldo David; Bortolozzi, Raul; Lupo, Sergio Horacio; Longo, Nadia; Rampakakis, Emmanouil; Ackad, Nabil; Sampalis, John S

    2011-01-01

    To compare the efficacy and safety of an individualized treatment-simplification strategy consisting of switching from a highly-active anti-retroviral treatment (HAART) with a ritonavir-boosted protease inhibitor (PI/r) and 2 nucleoside reverse-transcriptase inhibitors (NRTIs) to lopinavir/ritonavir (LPV/r) monotherapy, with intensification by 2 NRTIs if necessary, to that of continuing their HAART. This is a one-year, randomized, open-label, multi-center study in virologically-suppressed HIV-1-infected adults on their first PI/r-containing treatment, randomized to either LPV/r-monotherapy or continue their current treatment. Treatment efficacy was determined by plasma HIV-1 RNA viral load (VL), time-to-virologic rebound, patient-reported outcomes (PROs) and CD4+T-cell-count changes. Safety was assessed with the incidence of treatment-emergent adverse events (AE). Forty-one patients were randomized to LPV/r and 39 to continue their HAART. No statistically-significant differences between the two study groups in demographics and baseline characteristics were observed. At day-360, 71(39:LPV/r;32:HAART) patients completed treatment, while 9(2:LPV/r;7:HAART) discontinued. In a Last Observation Carried Forward Intent-to-Treat analysis, 40(98%) patients on LPV/r and 37(95%) on HAART had VL<200 copies/mL (P = 0.61). Time-to-virologic rebound, changes in PROs, CD4+ T-cell-count and VL from baseline, also exhibited no statistically-significant between-group differences. Most frequent AEs were diarrhea (19%), headache (18%) and influenza (16%). Four (10%) patients on LPV/r were intensified with 2 NRTIs, all regaining virologic control. Eight serious AEs were reported by 5(2:LPV/r;3:HAART) patients. At day-360, virologic efficacy and safety of LPV/r appears comparable to that of a PI+2NRTIs HAART. These results suggest that our individualized, simplified maintenance strategy with LPV/r-monotherapy and protocol-mandated NRTI re-introduction upon viral rebound, in

  8. Pilot, Randomized Study Assessing Safety, Tolerability and Efficacy of Simplified LPV/r Maintenance Therapy in HIV Patients on the 1st PI-Based Regimen

    Science.gov (United States)

    Cahn, Pedro; Montaner, Julio; Junod, Patrice; Patterson, Patricia; Krolewiecki, Alejandro; Andrade-Villanueva, Jaime; Cassetti, Isabel; Sierra-Madero, Juan; Casiró, Arnaldo David; Bortolozzi, Raul; Lupo, Sergio Horacio; Longo, Nadia; Rampakakis, Emmanouil; Ackad, Nabil; Sampalis, John S.

    2011-01-01

    Objectives To compare the efficacy and safety of an individualized treatment-simplification strategy consisting of switching from a highly-active anti-retroviral treatment (HAART) with a ritonavir-boosted protease inhibitor (PI/r) and 2 nucleoside reverse-transcriptase inhibitors (NRTIs) to lopinavir/ritonavir (LPV/r) monotherapy, with intensification by 2 NRTIs if necessary, to that of continuing their HAART. Methods This is a one-year, randomized, open-label, multi-center study in virologically-suppressed HIV-1-infected adults on their first PI/r-containing treatment, randomized to either LPV/r-monotherapy or continue their current treatment. Treatment efficacy was determined by plasma HIV-1 RNA viral load (VL), time-to-virologic rebound, patient-reported outcomes (PROs) and CD4+T-cell-count changes. Safety was assessed with the incidence of treatment-emergent adverse events (AE). Results Forty-one patients were randomized to LPV/r and 39 to continue their HAART. No statistically-significant differences between the two study groups in demographics and baseline characteristics were observed. At day-360, 71(39:LPV/r;32:HAART) patients completed treatment, while 9(2:LPV/r;7:HAART) discontinued. In a Last Observation Carried Forward Intent-to-Treat analysis, 40(98%) patients on LPV/r and 37(95%) on HAART had VL<200copies/mL (P = 0.61). Time-to-virologic rebound, changes in PROs, CD4+ T-cell-count and VL from baseline, also exhibited no statistically-significant between-group differences. Most frequent AEs were diarrhea (19%), headache (18%) and influenza (16%). Four (10%) patients on LPV/r were intensified with 2 NRTIs, all regaining virologic control. Eight serious AEs were reported by 5(2:LPV/r;3:HAART) patients. Conclusion At day-360, virologic efficacy and safety of LPV/r appears comparable to that of a PI+2NRTIs HAART. These results suggest that our individualized, simplified maintenance strategy with LPV/r-monotherapy and protocol-mandated NRTI re

  9. Pilot, randomized study assessing safety, tolerability and efficacy of simplified LPV/r maintenance therapy in HIV patients on the 1 PI-based regimen.

    Directory of Open Access Journals (Sweden)

    Pedro Cahn

    Full Text Available To compare the efficacy and safety of an individualized treatment-simplification strategy consisting of switching from a highly-active anti-retroviral treatment (HAART with a ritonavir-boosted protease inhibitor (PI/r and 2 nucleoside reverse-transcriptase inhibitors (NRTIs to lopinavir/ritonavir (LPV/r monotherapy, with intensification by 2 NRTIs if necessary, to that of continuing their HAART.This is a one-year, randomized, open-label, multi-center study in virologically-suppressed HIV-1-infected adults on their first PI/r-containing treatment, randomized to either LPV/r-monotherapy or continue their current treatment. Treatment efficacy was determined by plasma HIV-1 RNA viral load (VL, time-to-virologic rebound, patient-reported outcomes (PROs and CD4+T-cell-count changes. Safety was assessed with the incidence of treatment-emergent adverse events (AE.Forty-one patients were randomized to LPV/r and 39 to continue their HAART. No statistically-significant differences between the two study groups in demographics and baseline characteristics were observed. At day-360, 71(39:LPV/r;32:HAART patients completed treatment, while 9(2:LPV/r;7:HAART discontinued. In a Last Observation Carried Forward Intent-to-Treat analysis, 40(98% patients on LPV/r and 37(95% on HAART had VL<200 copies/mL (P = 0.61. Time-to-virologic rebound, changes in PROs, CD4+ T-cell-count and VL from baseline, also exhibited no statistically-significant between-group differences. Most frequent AEs were diarrhea (19%, headache (18% and influenza (16%. Four (10% patients on LPV/r were intensified with 2 NRTIs, all regaining virologic control. Eight serious AEs were reported by 5(2:LPV/r;3:HAART patients.At day-360, virologic efficacy and safety of LPV/r appears comparable to that of a PI+2NRTIs HAART. These results suggest that our individualized, simplified maintenance strategy with LPV/r-monotherapy and protocol-mandated NRTI re-introduction upon viral rebound, in

  10. Final Environmental Assessment: Construction of Maintenance and Storage Facility, Perimeter Fence Upgrade and Demolition of Three Buildings and Two Structures Gila River Air Force Space Surveillance Station Arizona

    Science.gov (United States)

    2012-11-01

    Estrella mountain range is approximately six miles west of the Installation and the Sacaton mountain range lie approximate- ly six miles to the southeast...Structures 3-4 Figure 5. Geological Map of Gila River AFSSS and Vicinity Sierra Estrella Range Sacaton Range EA — Construct Maintenance & Storage

  11. Environmental assessment of radiological effluents from data gathering and maintenance operation on Three Mile Island Unit 2: interim criteria approved by the Commission on April 7,1980

    International Nuclear Information System (INIS)

    1980-05-01

    The staff is currently in the process of preparing a programmatic environmental impact statement (PEIS) for TMI-2 which will address all radiological releases that may occur as a result of the cleanup and recovery operations. These operations will begin after the PEIS is published in final form provided the proposed cleanup programs have been found to be environmentally acceptable. In the interim period it is necessary for the licensee to conduct data gathering and maintenance operations on the damaged reactor. The action of approval of these interim operations does not foreclose any of the options of the PEIS. In addition, regardless of what cleanup choice is made in the PEIS, the approval of these data gathering and maintenance operations enhance the ability of the licensee to maintain the reactor in a safe configuration and to plan effectively for recovery operations. This Environmental Impact Appraisal evaluates the effects on the environment of allowing these data gathering and maintenance operations to be conducted. These data gathering and maintenance operations do not include purging of the containment atmosphere, disposal of EPICOR-II water, or the treatment and disposal of high level radioactively contaminated water in the reactor building

  12. Maintenance quality assurance peer exchange 2.

    Science.gov (United States)

    2009-04-01

    This report documents a comprehensive study of twenty three maintenance quality assurance : (MQA) programs throughout the United States and Canada. The policies and standards of : each program were synthesized to create a general assessment on the co...

  13. RhNAC2 and RhEXPA4 Are Involved in the Regulation of Dehydration Tolerance during the Expansion of Rose Petals1[C][W][OA

    Science.gov (United States)

    Dai, Fanwei; Zhang, Changqing; Jiang, Xinqiang; Kang, Mei; Yin, Xia; Lü, Peitao; Zhang, Xiao; Zheng, Yi; Gao, Junping

    2012-01-01

    Dehydration inhibits petal expansion resulting in abnormal flower opening and results in quality loss during the marketing of cut flowers. We constructed a suppression subtractive hybridization library from rose (Rosa hybrida) flowers containing 3,513 unique expressed sequence tags and analyzed their expression profiles during cycles of dehydration. We found that 54 genes were up-regulated by the first dehydration, restored or even down-regulated by rehydration, and once again up-regulated by the second dehydration. Among them, we identified a putative NAC family transcription factor (RhNAC2). With transactivation activity of its carboxyl-terminal domain in yeast (Saccharomyces cerevisiae) cell and Arabidopsis (Arabidopsis thaliana) protoplast, RhNAC2 belongs to the NAC transcription factor clade related to plant development in Arabidopsis. A putative expansin gene named RhEXPA4 was also dramatically up-regulated by dehydration. Silencing RhNAC2 or RhEXPA4 in rose petals by virus-induced gene silencing significantly decreased the recovery of intact petals and petal discs during rehydration. Overexpression of RhNAC2 or RhEXPA4 in Arabidopsis conferred strong drought tolerance in the transgenic plants. RhEXPA4 expression was repressed in RhNAC2-silenced rose petals, and the amino-terminal binding domain of RhNAC2 bound to the RhEXPA4 promoter. Twenty cell wall-related genes, including seven expansin family members, were up-regulated in Arabidopsis plants overexpressing RhNAC2. These data indicate that RhNAC2 and RhEXPA4 are involved in the regulation of dehydration tolerance during the expansion of rose petals and that RhEXPA4 expression may be regulated by RhNAC2. PMID:23093360

  14. The preventive effect of recombinant human growth factor (rhEGF) on the recurrence of radiodermatitis

    International Nuclear Information System (INIS)

    Ryu, Seung-Hee; Kim, Yeun-Hwa; Lee, Sang-Wook; Hong, Joon-Pio

    2010-01-01

    The effects of topical application of recombinant human epidermal growth factor (rhEGF) on wound healing and the recurrence of radiodermatitis were assessed in the irradiated skin of BALB/c Nu/Nu mice. Mice irradiated with 45 Gy of radiation were divided into 5 groups and treated with 10, 50, and 100 μg/g rhEGF ointment, vehicle alone, or no treatment (control) for 6 months. Wounds were observed initially in all groups and complete healing time (HT 100 ) for initial wound repair did not differ significantly among groups. However, the rate of recurrence over 6 months was significantly lower in the EGF-treated groups than in the control group (p<0.05). Histological examination showed that treatment with the optimum dose of EGF (50 μg/g) accelerated normal wound healing when compared with the higher dose of EGF (100 μg/g), vehicle alone, or no treatment, with the latter group showing irregular epidermal thickness, poor definition of epidermis and dermis, and unstable dermal structure. Collagen distribution was also significantly increased in mice treated with 50 μg/g rhEGF (p<0.05) compared with the control or vehicle-treated group. Taken together, these results indicate that treatment with exogenous EGF (50 μg/g dose) can enhance radiation-induced wound repair while preserving structural tissue stability and preventing the recurrence of radiodermatitis. (author)

  15. Maintenance analysis method and operational feedback: a comprehensive maintenance management

    International Nuclear Information System (INIS)

    Mathieu Riou; Victor Planchon

    2006-01-01

    components instead of cask. Safety Analysis Reports have now exhaustive periodic upkeep program, listing all the inspections mandatory to guarantee transportations safety and cask's conformity with current approval certificates. Some inspections have been deleted, leading to a radiation exposure reduction. Some criteria have been widened, leading to replacement component optimization. It is currently too early to have a precise estimation of waste optimization, as the relation between waste quantity and maintenance operations. This methodology will be applied on the other casks of the COGEMA LOGISTICS fleet. As soon as the new procedures are applicable, an assessment will be carried out. (authors)

  16. Cloning and functional analysis of promoters of three GnRH genes in a cichlid

    International Nuclear Information System (INIS)

    Kitahashi, Takashi; Sato, Hideki; Sakuma, Yasuo; Parhar, Ishwar S.

    2005-01-01

    Mechanisms regulating gonadotropin-releasing hormone (GnRH) types, a key molecule for reproductive physiology, remain unclear. In the present study, we cloned the promoters of GnRH1, GnRH2, and GnRH3 genes in the tilapia, Oreochromis niloticus; and found putative binding sites for glucocorticoid receptors, Sp1, C/EBP, GATA, and Oct-1, but not for androgen receptors in all three GnRH promoters using computer analysis. The presence of binding sites for progesterone receptors in GnRH1, estrogen receptors in GnRH1 and GnRH2, and thyroid hormone receptors in GnRH1 and GnRH3 suggests direct action of steroid hormones on GnRH types. Our observation of SOX and LINE-like sequences exclusively in GnRH1, COUP in GnRH2, and retinoid X receptors in GnRH3 suggests their role in sexual differentiation, midbrain segmentation, and visual cue integration, respectively. Thus, the characteristic binding sites for nuclear receptors and transcription factors support the notion that each GnRH type is regulated differently and has distinct physiological roles

  17. Modelling inspection policies for building maintenance.

    Science.gov (United States)

    Christer, A H

    1982-08-01

    A method of assessing the potential of an inspection maintenance policy as opposed to an existing breakdown maintenance policy for a building complex is developed. The method is based upon information likely to be available and specific subjective assessments which could be made available. Estimates of the expected number of defects identified at an inspection and the consequential cost saving are presented as functions of the inspection frequency.

  18. Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep

    Directory of Open Access Journals (Sweden)

    SERGIO E RECABARREN

    2007-01-01

    Full Text Available Although evidence is accumulating that prenatal testosterone (T compromises reproductive function in the female, the effects of excess T in utero on the postnatal development of male reproductive function has not been studied. The aim of this study was to assess the influence of prenatal T excess on age-related changes in pituitary and gonadal responsiveness to GnRH in the male sheep. We used the GnRH agonist, leuprolide (10 µg/kg, as a pharmacologic challenge at 5, 10, 20 and 30 weeks of age. These time points correspond to early and late juvenile periods and the prepubertal and postpubertal periods of sexual development, respectively. LH and T were measured in blood samples collected before and after GnRH agonist administration. The area under the response curve (AUC of LH increased progressively in both controls and prenatal T-treated males from 5 to 20 weeks of age (P<0.01. The LH responses in prenatal T-treated males were lower at 20 and 30 weeks of age compared to controls (P<0.05. AUC-T increased progressively in control males from 5 through 30 weeks of age and prenatal T-treated males from 5 to 20 weeks of age. The T response in prenatal T-treated males was higher at 20 weeks compared to controls of same age but similar to controls and prenatal T-treated males at 30 weeks of age (P <0.05. Our findings suggest that prenatal T treatment advances the developmental trajectory of gonadal responsiveness to GnRH in male offspring

  19. Random maintenance policies

    CERN Document Server

    Nakagawa, Toshio

    2014-01-01

    Exploring random maintenance models, this book provides an introduction to the implementation of random maintenance, and it is one of the first books to be written on this subject.  It aims to help readers learn new techniques for applying random policies to actual reliability models, and it provides new theoretical analyses of various models including classical replacement, preventive maintenance and inspection policies. These policies are applied to scheduling problems, backup policies of database systems, maintenance policies of cumulative damage models, and reliability of random redundant systems. Reliability theory is a major concern for engineers and managers, and in light of Japan’s recent earthquake, the reliability of large-scale systems has increased in importance. This also highlights the need for a new notion of maintenance and reliability theory, and how this can practically be applied to systems. Providing an essential guide for engineers and managers specializing in reliability maintenance a...

  20. Framework for Maintenance Planning

    DEFF Research Database (Denmark)

    Soares, C. Guedes; Duarte, J. Caldeira; Garbatov, Y.

    2010-01-01

    the design and during the whole life span of operational use, within an integrated framework founded on risk and reliability based techniques. The document addresses designers, decision makers and professionals responsible for or involved in establishing maintenance plans. The purpose of this document......The present document presents a framework for maintenance planning. Maintenance plays a fundamental role in counteracting degradation effects, which are present in all infrastructure and industrial products. Therefore, maintenance planning is a very critical aspect to consider both during...... is to present maintenance as an integrated approach that needs to be planned, designed, engineered, and controlled by proper qualitative and quantitative techniques. This document outlines the basic premises for maintenance planning and provides the general philosophies that can be followed and points to a best...

  1. Suncor maintenance and reliability

    Energy Technology Data Exchange (ETDEWEB)

    Little, S. [Suncor Energy, Calgary, AB (Canada)

    2006-07-01

    Fleet maintenance and reliability at Suncor Energy was discussed in this presentation, with reference to Suncor Energy's primary and support equipment fleets. This paper also discussed Suncor Energy's maintenance and reliability standard involving people, processes and technology. An organizational maturity chart that graphed organizational learning against organizational performance was illustrated. The presentation also reviewed the maintenance and reliability framework; maintenance reliability model; the process overview of the maintenance and reliability standard; a process flow chart of maintenance strategies and programs; and an asset reliability improvement process flow chart. An example of an improvement initiative was included, with reference to a shovel reliability review; a dipper trip reliability investigation; bucket related failures by type and frequency; root cause analysis of the reliability process; and additional actions taken. Last, the presentation provided a graph of the results of the improvement initiative and presented the key lessons learned. tabs., figs.

  2. MRI of transforaminal lumbar interbody fusion: imaging appearance with and without the use of human recombinant bone morphogenetic protein-2 (rhBMP-2)

    Energy Technology Data Exchange (ETDEWEB)

    Fox, Michael G.; Goldberg, Judd M.; Gaskin, Cree M.; Barr, Michelle S.; Alford, Bennett [University of Virginia, Department of Radiology and Medical Imaging, Charlottesville, VA (United States); Patrie, James T. [University of Virginia, Department of Public Health Sciences, Charlottesville, VA (United States); Shen, Francis H. [University of Virginia, Department of Orthopedic Surgery, Charlottesville, VA (United States)

    2014-09-15

    To describe the vertebral endplate and intervertebral disc space MRI appearance following TLIF, with and without the use of rhBMP-2, and to determine if the appearance is concerning for discitis/osteomyelitis. After institutional review board approval, 116 TLIF assessments performed on 75 patients with rhBMP-2 were retrospectively and independently reviewed by five radiologists and compared to 73 TLIF assessments performed on 45 patients without rhBMP-2. MRIs were evaluated for endplate signal, disc space enhancement, disc space fluid, and abnormal paraspinal soft tissue. Endplate edema-like signal was reported when T1-weighted hypointensity, T2-weighted hyperintensity, and endplate enhancement were present. Subjective concern for discitis/osteomyelitis on MRI was graded on a five-point scale. Generalized estimating equation binomial regression model analysis was performed with findings correlated with rhBMP-2 use, TLIF level, graft type, and days between TLIF and MRI. The rhBMP-2 group demonstrated endplate edema-like signal (OR 5.66; 95 % CI [1.58, 20.24], p = 0.008) and disc space enhancement (OR 2.40; 95 % CI [1.20, 4.80], p = 0.013) more often after adjusting for the TLIF level, graft type, and the number of days following TLIF. Both groups had a similar temporal distribution for endplate edema-like signal but disc space enhancement peaked earlier in the rhBMP-2 group. Disc space fluid was only present in the rhBMP-2 group. Neither group demonstrated abnormal paraspinal soft tissue and discitis/osteomyelitis was not considered likely in any patient. Endplate edema-like signal and disc space enhancement were significantly more frequent and disc space enhancement developed more rapidly following TLIF when rhBMP-2 was utilized. The concern for discitis/osteomyelitis was similar and minimal in both groups. (orig.)

  3. Software evolution and maintenance

    CERN Document Server

    Tripathy, Priyadarshi

    2014-01-01

    Software Evolution and Maintenance: A Practitioner's Approach is an accessible textbook for students and professionals, which collates the advances in software development and provides the most current models and techniques in maintenance.Explains two maintenance standards: IEEE/EIA 1219 and ISO/IEC14764Discusses several commercial reverse and domain engineering toolkitsSlides for instructors are available onlineInformation is based on the IEEE SWEBOK (Software Engineering Body of Knowledge)

  4. Status of fusion maintenance

    International Nuclear Information System (INIS)

    Fuller, G.M.

    1984-01-01

    Effective maintenance will be an essential ingredient in determining fusion system productivity. This level of productivity will result only after close attention is paid to the entire system as an entity and appropriate integration of the elements is made. The status of fusion maintenance is reviewed in the context of the entire system. While there are many challenging developmental tasks ahead in fusion maintenance, the required technologies are available in several high-technology industries, including nuclear fission

  5. Laboratory equipment maintenance contracts.

    Science.gov (United States)

    Boudreau, D A; Scheer, W D; Catrou, P G

    1985-12-01

    The increasing level of technical sophistication and complexity found in clinical laboratory instrumentation today more than ever demands careful attention to maintenance service needs. The time-worn caution for careful definition of requirements for acquisition of a system should also carry over to acquisition of maintenance service. Guidelines are presented for specifications of terms and conditions for maintenance service from the perspective of the laboratorian in the automated clinical laboratory.

  6. Interactive videodisc in maintenance

    International Nuclear Information System (INIS)

    Zwingelstein, G.; Nguyen Van Nghi, B.

    1986-01-01

    After a recall of the videodisc characteristics, this paper presents its utilization by Electricite de France in the framework of training and maintenance. The SICMA (Interactive Communication System in Maintenance) developed and tested by Electricte de France is presented as also its utilization. It has been tested on the sites of Dampierre and Paluel in the cases of training and maintenance (deconnexion of drive rods of control elements); the conclusions of this experimentation are finally given. 4 refs [fr

  7. Turbine maintenance and modernization

    Energy Technology Data Exchange (ETDEWEB)

    Unga, E. [Teollisuuden Voima Oy, Olkiluoto (Finland)

    1998-12-31

    The disturbance-free operation of the turbine plant plays an important role in reaching good production results. In the turbine maintenance of the Olkiluoto nuclear power plant the lifetime and efficiency of turbine components and the lifetime costs are taken into account in determining the turbine maintenance and modernization/improvement program. The turbine maintenance program and improvement/modernization measures taken in the plant units are described in this presentation. (orig.)

  8. Turbine maintenance and modernization

    Energy Technology Data Exchange (ETDEWEB)

    Unga, E [Teollisuuden Voima Oy, Olkiluoto (Finland)

    1999-12-31

    The disturbance-free operation of the turbine plant plays an important role in reaching good production results. In the turbine maintenance of the Olkiluoto nuclear power plant the lifetime and efficiency of turbine components and the lifetime costs are taken into account in determining the turbine maintenance and modernization/improvement program. The turbine maintenance program and improvement/modernization measures taken in the plant units are described in this presentation. (orig.)

  9. The system Cu-Rh-S at 900 degrees, 700 degrees, 540 degrees and 500 degrees C

    DEFF Research Database (Denmark)

    Karup-Møller, Sven; Makovicky, E.

    2007-01-01

    Phase relations in the dry condensed system Cu-Rh-S were determined at 900, 700, 540 and 500 degrees C. At 900 degrees C, the system contains digenite, four rhodium sulfides (Rh17S15, Rh3S4, Rh2S3 and RhS similar to 3), three ternary sulfides (CuRh2S4, CuxRhS3+x and a fibrous sulfide in the range...

  10. Industrial Maintenance Strategies

    International Nuclear Information System (INIS)

    Sajjad Akbar

    2006-01-01

    Industrial plants have become more complex due to technological advancement. This has made the task of maintenance more difficult. The maintenance costs in terms of resources and downtime loss are so high that maintenance function has become a critical factor in a plant's profitability. Industry should devote as much forethought to the management of maintenance function as to production. Maintenance has grown from an art to a precise, technical engineering science. Planning, organizing scheduling and control of maintenance using modern techniques pays dividends in the form of reduced costs and increased reliability. The magnitude and the dimension of maintenance have multiplied due to development in the engineering technologies. Production cost and capacities are directly affected by the breakdown time. Total operating cost including the maintenance cost plays an important role in replacement dimension. The integrated system approach would bring forth the desired results of high maintenance standards. The standards once achieved and sustained, would add to the reliability of the plan and relieve heavy stresses and strains on the engineering logistic support. (author)

  11. Analysis of maintenance strategies

    International Nuclear Information System (INIS)

    Laakso, K.; Simola, K.

    1998-01-01

    The main topics of the presentation include: (1) an analysis model and methods to evaluate maintenance action programs and the support decision to make changes in them and (2) to understand the maintenance strategies in a systems perspective as a basis for future developments. The subproject showed how systematic models for maintenance analysis and decision support, utilising computerised and statistical tool packages, can be taken into use for evaluation and optimisation of maintenance of active systems from the safety and economic point of view

  12. Remote Maintenance Monitoring System -

    Data.gov (United States)

    Department of Transportation — The Remote Maintenance and Monitoring System (RMMS) is a collection of subsystems that includes telecommunication components, hardware, and software, which serve to...

  13. Army Maintenance System Transformation

    National Research Council Canada - National Science Library

    Gilbertson, Frank V

    2006-01-01

    .... Used in conjunction with pertinent historical data and developed with Army transformation goals in mind, General Systems thinking can provide the framework for guiding maintenance transformation...

  14. 77 FR 67584 - Air Carrier Contract Maintenance Requirements

    Science.gov (United States)

    2012-11-13

    ... many, including air carriers lowering costs by employing fewer maintenance personnel and reducing their... make accurate risk assessments. B. History In May 1996, employees of SabreTech, a contract maintenance...-certificated repair facilities, and the air carriers' outsourcing of maintenance. In each of those reports...

  15. Evolution of triaxial shapes at large isospin: Rh isotopes

    Directory of Open Access Journals (Sweden)

    A. Navin

    2017-04-01

    Full Text Available The rotational response as a function of neutron–proton asymmetry for the very neutron-rich isotopes of Rh (116–119Rh has been obtained from the measurement of prompt γ rays from isotopically identified fragments, produced in fission reactions at energies around the Coulomb barrier. The measured energy “signature” splitting of the yrast bands, when compared with the Triaxial Projected Shell Model (TPSM calculations, shows the need for large, nearly constant, triaxial deformations. The present results are compared with global predictions for the existence of non axial shapes in the periodic table in the case of very neutron-rich nuclei Rh isotopes. The predicted trend of a second local maximum for a triaxial shape around N∼74 is not found.

  16. Chemoselective hydrogenation of arenes by PVP supported Rh nanoparticles

    DEFF Research Database (Denmark)

    Ibrahim, Mahmoud; Poreddy, Raju; Philippot, Karine

    2016-01-01

    Polyvinylpyrrolidone-stabilized Rh nanoparticles (RhNPs/PVP) of ca. 2.2 nm in size were prepared by the hydrogenation of the organometallic complex [Rh(η3-C3H5)3] in the presence of PVP and evaluated as a catalyst in the hydrogenation of a series of arene substrates as well as levulinic acid...... for the hydrogenation of levulinic acid and methyl levulinate in water leading to quantitative formation of the fuel additive γ-valerolactone under moderate reaction conditions compared to previously reported catalytic systems....... and methyl levulinate. The catalyst showed excellent activity and selectivity towards aromatic ring hydrogenation compared to other reported transition metal-based catalysts under mild reaction conditions (room temperature and 1 bar H2). Furthermore, it was shown to be a highly promising catalyst...

  17. Physical Modelling Of The Steel Flow In RH Apparatus

    Directory of Open Access Journals (Sweden)

    Pieprzyca J.

    2015-09-01

    Full Text Available The efficiency of vacuum steel degassing using RH methods depends on many factors. One of the most important are hydrodynamic processes occurring in the ladle and vacuum chamber. It is always hard and expensive to determine the flow character and the way of steel mixing in industrial unit; thus in this case, methods of physical modelling are applied. The article presents the results of research carried out on the water physical model of RH apparatus concerning the influence of the flux value of inert gas introduced through the suck legs on hydrodynamic conditions of the process. Results of the research have visualization character and are presented graphically as a RTD curves. The main aim of such research is to optimize the industrial vacuum steel degassing process by means of RH method.

  18. Evaluation of (101)Rh as a brachytherapy source.

    Science.gov (United States)

    Pakravan, Delaram; Ghorbani, Mahdi; Meigooni, Ali Soleimani

    2015-04-01

    Recently a number of hypothetical sources have been proposed and evaluated for use in brachytherapy. In the present study, a hypothetical (101)Rh source with mean photon energy of 121.5 keV and half-life of 3.3 years, has been evaluated as an alternative to the existing high-dose-rate (HDR) sources. Dosimetric characteristics of this source model have been determined following the recommendation of the Task Group 43 (TG-43) of the American Association of the Physicist in Medicine (AAPM), and the results are compared with the published data for (57)Co source and Flexisource (192)Ir sources with similar geometries. MCNPX Monte Carlo code was used for simulation of the (101)Rh hypothetical HDR source design. Geometric design of this hypothetical source was considered to be similar to that of Flexisource (192)Ir source. Task group No. 43 dosimetric parameters, including air kerma strength per mCi, dose rate constant, radial dose function, and two dimensional (2D) anisotropy functions were calculated for the (101)Rh source through simulations. Air kerma strength per activity and dose rate constant for the hypothetical (101)Rh source were 1.09 ± 0.01 U/mCi and 1.18 ± 0.08 cGy/(h.U), respectively. At distances beyond 1.0 cm in phantom, radial dose function for the hypothetical (101)Rh source is higher than that of (192)Ir. It has also similar 2D anisotropy functions to the Flexisource (192)Ir source. (101)Rh is proposed as an alternative to the existing HDR sources for use in brachytherapy. This source provides medium energy photons, relatively long half-life, higher dose rate constant and radial dose function, and similar 2D anisotropy function to the Flexisource (192)Ir HDR source design. The longer half-life of the source reduces the frequency of the source exchange for the clinical environment.

  19. Radiation chemical behavior of Rh(III) in HClO4 and HNO3

    International Nuclear Information System (INIS)

    Vladimirova, M.V.; Khalkina, E.V.

    1995-01-01

    The radiation chemical behavior of Rh is very interesting since Rh accumulates in irradiated U but has not been reported in the literature. Scattered data do exist for the radiation chemical behavior of Rh(III) in weakly acidic and alkaline solutions. Pulsed radiolysis was used to investigate the formation of unstable oxidation states of Rh during reduction and oxidation of Rh(III) in neutral solutions. The rate constant of the reaction Rh(III) + e aq - was found to be 6·10 10 liter/mole·sec. The radiation chemical behavior of Rh(III) toward γ-radiolysis in neutral, weakly acidic (up to 0.1 N), and alkaline solutions was examined. In neutral solutions of [Rh(NH 3 ) 5 Cl]Cl 2 and RhCl 3 , metallic Rh is formed. The degree of reduction is ∼ 1%. In neutral and weakly acidic solutions of Rh(NO 3 ) 3 , Rh 2 O 3 ·xH 2 O is formed. Irradiation of Rh(ClO 4 ) 3 solutions produces no reduction. The radiation chemical behavior of Rh(III) in HClO 4 and HNO 3 solutions at concentrations > 1 M is studied in the present work

  20. Structure sensitivity of CO dissociation on Rh surfaces

    DEFF Research Database (Denmark)

    Mavrikakis, Manos; Baumer, M.; Freund, H.J.

    2002-01-01

    than the flat surface, but the effect is considerably weaker than the effect of surface structure on the dissociation barrier. Our findings are compared with available experimental data, and the consequences for CO activation in methanation and Fischer-Tropsch reactions are discussed.......Using periodic self-consistent density functional calculations it is shown that the barrier for CO dissociation is similar to120 kJ/mol lower on the stepped Rh(211) surface than on the close-packed Rh(111) surface. The stepped surface binds molecular CO and the dissociation products more strongly...

  1. TOTAL PRODUCTIVE MAINTENANCE, A CENTRAL PREOCCUPATION OF THE MANAGERS

    OpenAIRE

    Daniela POPESCU; Adriana SCRIOŞTEANU; ANDREI POPESCU

    2013-01-01

    This present study demonstrates that the role of the mangers in the productive maintenance is currently becoming more important. This assessment is formulated starting from the daily realities regarding the growth of the proportions of productions and along with these the growth of the volume of equipments which need a better care and maintenance for a proper operation. The productive maintenance has developed and emerged out of this necessity. Therefore, the productive maintenance in the eco...

  2. Maintenance Trades Guidelines

    Science.gov (United States)

    Weidner, Theodore J.

    2008-01-01

    In 2002, APPA published "Maintenance Staffing Guidelines for Educational Facilities," the first building maintenance trades staffing guideline designed to assist educational facilities professionals with their staffing needs. addresses how facilities professionals can determine the appropriate size and mix of their organization. Contents…

  3. Using the system maintenance datastore to characterize lifetime maintenance for PLiM

    International Nuclear Information System (INIS)

    Watson, P.; Dam, R.; Nickerson, J.

    2004-01-01

    A comprehensive Plant Life Management (PLiM) program involves evaluating a large amount of information. For any plant, there are numerous maintenance, surveillance and inspection programs for the important systems, structures and components. There is extensive industry experience on component failure modes, degradation mechanisms and recommended maintenance practices. This information forms the basis of the aging assessment work, through which improvements to these plant programs are identified. AECL has developed several tools to manage the quantities of information required in aging assessment studies, such as the SYSTMS (SYtematic approach for the development of STrategy for Maintenance and Surveillance) tool and the System Maintenance Datastore (SMD). The SMD has been developed to serve as a hub to a Systematic based Adaptive Maintenance Program (SAMP), by storing maintenance resource requirements for recommended maintenance tasks for use by the other processes in a SAMP. The SMD can be used to (a) quantify the savings or cost of optimising a maintenance program, (b) characterize and understand long term trends in condition-based maintenance due to component aging, (c) quantify the resource savings due to optimum timing of component replacement or general plant refurbishment, and (d) provide aging assessment cost information for input to plant asset evaluation. The SMD contains data for regular maintenance program tasks, plant condition assessment recommendations, and equipment refurbishment costs. A prototype SMD has been developed with data tables populated with information from operating CANDU stations. The SMD is now available to be used either with a SYSTMS evaluation or with a plant's database of maintenance tasks. (author)

  4. Review of maintenance personnel practices at nuclear power plants

    International Nuclear Information System (INIS)

    Chockie, A.D.; Badalamente, R.V.; Hostick, C.J.; Vickroy, S.C.; Bryant, J.L.; Imhoff, C.H.

    1984-05-01

    As part of the Nuclear Regulatory Commission (NRC) sponsored Maintenance Qualifications and Staffing Project, the Pacific Northwest Laboratory (PNL) has conducted a preliminary assessment of nuclear power plant (NPP) maintenance practices. As requested by the NRC, the following areas within the maintenance function were examined: personnel qualifications, maintenance training, overtime, shiftwork and staffing levels. The purpose of the assessment was to identify the primary safety-related problems that required further analysis before specific recommendations can be made on the regulations affecting NPP maintenance operations

  5. Risk of severe ovarian hyperstimulation syndrome in GnRH antagonist versus GnRH agonist protocol

    DEFF Research Database (Denmark)

    Toftager, M.; Bogstad, J; Bryndorf, T

    2016-01-01

    interval (CI): 0.33-0.57) compared with the traditional GnRH agonist protocol. Previous trials comparing the two protocols mainly included selected patient populations, a limited number of patients and the applied OHSS criteria differed, making direct comparisons difficult. In two recent large meta...... IV, dual-centre, open-label, RCT including 1050 women allocated to either short GnRH antagonist or long GnRH agonist protocol in a 1:1 ratio and enrolled over a 5-year period using a web-based concealed randomization code. This is a superiority study designed to detect a difference in severe OHSS...... between the two arms. None of the women had undergone previous ART treatment. PARTICIPANTS/MATERIALS, SETTING, METHODS: All infertile women referred for their first IVF/ICSI at two public fertility clinics, less than 40 years of age and with no uterine malformations were asked to participate. A total...

  6. Cross section measurement for the reaction /sup 103/Rh (n,n') /sup 103m/Rh

    International Nuclear Information System (INIS)

    Paulsen, A.; Liskien, H.; Vaninbroukx, R.; Widera, R.

    1980-01-01

    The excitation function for the reaction /sup 103/Rh (n,n') /sup 103m/Rh was measured by the activation technique from 0.2 to 6.1 MeV in 0.1-MeV steps and from 13.0 to 16.7 MeV in 1-MeV steps. This excitation function is normalized through an absolute measurement at 1.8 MeV. This measurement is based on n-p scattering for neutron flux determination and on liquid scintillation counting of /sup 103m/Rh separated from /sup 103/Pd solutions for the activity determination. The total uncertainty of the cross-section results is typically + or -5% above 0.5 MeV (about + or -10% above 13 MeV). Concurrence with existing data is good except below 0.35 MeV, where the present results are considerably higher

  7. Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood.

    Science.gov (United States)

    Roland, Alison V; Moenter, Suzanne M

    2011-02-01

    Prenatal androgenization (PNA) of female mice with dihydrotestosterone programs reproductive dysfunction in adulthood, characterized by elevated luteinizing hormone levels, irregular estrous cycles, and central abnormalities. Here, we evaluated activity of GnRH neurons from PNA mice and the effects of in vivo treatment with metformin, an activator of AMP-activated protein kinase (AMPK) that is commonly used to treat the fertility disorder polycystic ovary syndrome. Estrous cycles were monitored in PNA and control mice before and after metformin administration. Before metformin, cycles were longer in PNA mice and percent time in estrus lower; metformin normalized cycles in PNA mice. Extracellular recordings were used to monitor GnRH neuron firing activity in brain slices from diestrous mice. Firing rate was higher and quiescence lower in GnRH neurons from PNA mice, demonstrating increased GnRH neuron activity. Metformin treatment of PNA mice restored firing activity and LH to control levels. To assess whether AMPK activation contributed to the metformin-induced reduction in GnRH neuron activity, the AMPK antagonist compound C was acutely applied to cells. Compound C stimulated cells from metformin-treated, but not untreated, mice, suggesting that AMPK was activated in GnRH neurons, or afferent neurons, in the former group. GnRH neurons from metformin-treated mice also showed a reduced inhibitory response to low glucose. These studies indicate that PNA causes enhanced firing activity of GnRH neurons and elevated LH that are reversible by metformin, raising the possibility that central AMPK activation by metformin may play a role in its restoration of reproductive cycles in polycystic ovary syndrome.

  8. Effects of up to 15 years of recombinant human GH (rhGH) replacement on bone metabolism in adults with growth hormone deficiency (GHD): the Leiden Cohort Study.

    Science.gov (United States)

    Appelman-Dijkstra, Natasha M; Claessen, Kim M J A; Hamdy, Neveen A T; Pereira, Alberto M; Biermasz, Nienke R

    2014-11-01

    Growth hormone deficiency (GHD) in adulthood may be associated with a decreased bone mineral density (BMD), a decreased bone mineral content (BMC) and an increased fracture risk. Recombinant human GH (rhGH) replacement induces a progressive increase in BMD for up to 5-7 years of treatment. Data on longer follow-up are, however, scarce. Two hundred and thirty-adult GHD patients (mean age 47·1 years, 52·6% female), of whom 88% patients had adult-onset (AO) GHD, receiving rhGH replacement for ≥5 years were included in the study. Most patients had multiple pituitary hormone deficiencies. Bone turnover markers, BMC and BMD and T-scores at the lumbar spine and femoral neck were evaluated at baseline, and after 5, 10 and 15 years of rhGH replacement. In addition, clinical fracture incidence was assessed. Mean lumbar spine BMD, lumbar spine BMC and T-scores gradually increased during the first 10 years of rhGH replacement and remained stable thereafter. Largest effects of rhGH supplementation were found in men. In the small subset of patients using bisphosphonates, use of bisphosphonates did not impact additional beneficial effects in the long term. Low baseline BMD positively affected the change in BMD and BMC over time, but there was a negative effect of high GH dose at 1 year on the change in BMD and BMC over time. Clinical fracture incidence during long-term rhGH replacement was 20.1/1000 py. Fifteen years of rhGH replacement in GHD adults resulted in a sustained increase in BMD values at the lumbar spine, particularly in men, and stabilization of BMD values at the femoral neck. Clinical fracture incidence was suggested not to be increased during long-term rhGH replacement. © 2014 John Wiley & Sons Ltd.

  9. Maintenance improvement program

    International Nuclear Information System (INIS)

    Derbonne, D.R.; Plunkett, T.F.; Simpson, J.R.

    1989-01-01

    During fuel cycle 1 at River Bend station, considerable effort was expended to reduce corrective maintenance work orders (MWOs) to <1,000. This was done by complementing the plant staff with costly contract personnel. Coming out of the first refueling outage, most contract personnel were released. The change in MWO backlog started a steady rise. It became readily apparent that to avoid costly contract staff time, a maintenance improvement program (MIP) was necessary. The MIP Was primarily directed at two areas: crew efficiency improvements and improved preplanned MWO packages. The overall effect of the MIP was to achieve significant productivity improvements with reduced operation and maintenance cost by providing frequent accountability to all levels of maintenance supervision. The MIP also produced a feeling of pride among the maintenance department employees that had not really existed before. This was the best benefit of all

  10. Treatment of extremely severe acute hemopoietic radiation sickness beagles with RhG-CSF and RhIL-11

    International Nuclear Information System (INIS)

    Zhao Jianzhi; Zhang Ri; Li Ming; Xing Shuang; Luo Qingliang; Zhang Xueguang; Miao Jingcheng; Zhu Nankang

    2010-01-01

    Objective: To evaluate the effects of treatment combined recombinant human G-CSF (rhG-CSF) and recombinant human interleukin-11 (rhIL-11) on severe acute hemopoietic radiation sickness (ARS) beagles. Methods: Beagles were irradiated with 4.5 Gy 60 Co γ-ray to establish ARS models, and animals were divided into the irradiated control group and the supportive care and combined cytokines treatment cohort. After irradiation the irradiated control beagles was given no treatment, the supportive care beagles received purely symptomatic treatment including blood transfusion and anti-infection while the combined cytokines treatment beagles received rhG-CSF and rhIL-11 subcutaneously for three weeks besides symptomatic treatment.Results After irradiation, all kinds of cells' population declined sharply, but rebounded to normal basically in the combined cytokines treatment rate in the cohort. The mean blood transfusion volume of cytokines in the cohort and the period of blood transfusion all were less than those in the supportive care cohort (P<0.01). The period of administrated antibiotic of cytokines in the cohort was shorter than that in the supportive care cohort (P<0.05). In the observe period of 45 d, survival rate in the irradiated controls cohort was 0%, in the supportive care cohort was 80%, and in the combined cytokines treatment cohort was 100%(P<0.01). Conclusion: Administration of rhG-CSF and rhIL-11 early after irradiation and continued daily, in combined with supportive care in severe acute hemopoietic radiation sickness beagles can improve hematopoietic function restoration, stimulate blood cells to restore to the normal level quickly, significantly decrease the reguired volume of blood transfusion, shorten the period of anti-infection and increase survival of irradiated canines. (authors)

  11. GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome

    Science.gov (United States)

    Alama, Pilar; Bellver, Jose; Vidal, Carmen; Giles, Juan

    2013-01-01

    The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article. PMID:23825982

  12. Red cell autoantibodies characterized by competitive inhibition of iodine 125 Rh alloantibody binding and by immunoprecipitation of membrane proteins

    International Nuclear Information System (INIS)

    Pierce, S.W.; Victoria, E.J.; Masouredis, S.P.

    1990-01-01

    The relationship between determinants recognized by warm-type immunoglobulin G red cell autoantibodies and the Rh antigens was characterized by autoantibody competitive inhibition of iodine 125 Rh alloantibody binding and autoantibody immunoprecipitation of iodine 125 red blood cell membrane proteins. The majority of blood donor autoantibody recognized epitopes that are closely related to Rh antigens as determined by competitive inhibition studies. Eighteen of 20 (90%) autoantibodies inhibited anti-Rh(c) binding, 15 inhibited anti-Rh(E), 5 inhibited anti-Rh(D), and only 2 failed to inhibit any of the three Rh alloantibodies tested. Autoantibodies that inhibited anti-Rh(D) also inhibited anti-Rh(c) and anti-Rh(E) and all those that inhibited anti-Rh(E) also inhibited anti-Rh(c). Autoantibodies that inhibited all three Rh alloantibodies immunoprecipitated 30 kd membrane polypeptides, as did two of the three autoantibodies that inhibited only anti-Rh(c) and anti-Rh(E). One autoantibody in this group and two autoantibodies that inhibited only anti-Rh(c), as well as an autoantibody that did not inhibit any of the Rh alloantibodies, immunoprecipitated only a single membrane polypeptide identified as band 3. The majority of normal donor red blood cell autoantibodies inhibited the binding of Rh alloantibodies, which indicates that they either bound to the Rh polypeptides or to epitopes on band 3 that were closely associated with the Rh complex

  13. Computation of beam quality parameters for Mo/Mo, Mo/Rh, Rh/Rh, and W/Al target/filter combinations in mammography

    International Nuclear Information System (INIS)

    Kharrati, Hedi; Zarrad, Boubaker

    2003-01-01

    A computer program was implemented to predict mammography x-ray beam parameters in the range 20-40 kV for Mo/Mo, Mo/Rh, Rh/Rh, and W/Al target/filter combinations. The computation method used to simulate mammography x-ray spectra is based on the Boone et al. model. The beam quality parameters such as the half-value layer (HVL), the homogeneity coefficient (HC), and the average photon energy were computed by simulating the interaction of the spectrum photons with matter. The checking of this computation was done using a comparison of the results with published data and measured values obtained at the Netherlands Metrology Institute Van Swinden Laboratorium, National Institute of Standards and Technology, and International Atomic Energy Agency. The predicted values with a mean deviation of 3.3% of HVL, 3.7% of HC, and 1.5% of average photon energy show acceptable agreement with published data and measurements for all target/filter combinations in the 23-40 kV range. The accuracy of this computation can be considered clinically acceptable and can allow an appreciable estimation for the beam quality parameters

  14. GnRH signalling pathways and GnRH-induced homologous desensitization in a gonadotrope cell line (alphaT3-1).

    Science.gov (United States)

    Poulin, B; Rich, N; Mas, J L; Kordon, C; Enjalbert, A; Drouva, S V

    1998-07-25

    Exposure of the gonadotrope cells to gonadotropin-releasing hormone (GnRH) reduces their responsiveness to a new GnRH stimulation (homologous desensitization). The time frame as well as the mechanisms underlying this phenomenon are yet unclear. We studied in a gonadotrope cell line (alphaT3-1) the effects of short as well as long term GnRH pretreatments on the GnRH-induced phospholipases-C (PLC), -A2 (PLA2) and -D (PLD) activities, by measuring the production of IP3, total inositol phosphates (IPs), arachidonic acid (AA) and phosphatidylethanol (PEt) respectively. We demonstrated that although rapid desensitization of GnRH-induced IP3 formation did not occur in these cells, persistent stimulation of cells with GnRH or its analogue resulted in a time-dependent attenuation of GnRH-elicited IPs formation. GnRH-induced IPs desensitization was potentiated after direct activation of PKC by the phorbol ester TPA, suggesting the involvement of distinct mechanisms in the uncoupling exerted by either GnRH or TPA on GnRH-stimulated PI hydrolysis. The levels of individual phosphoinositides remained unchanged under any desensitization condition applied. Interestingly, while the GnRH-induced PLA2 activity was rapidly desensitized (2.5 min) after GnRH pretreatments, the neuropeptide-evoked PLD activation was affected at later times, indicating an important time-dependent contribution of these enzymatic activities in the sequential events underlying the GnRH-induced homologous desensitization processes in the gonadotropes. Under GnRH desensitization conditions, TPA was still able to induce PLD activation and to further potentiate the GnRH-evoked PLD activity. AlphaT3-1 cells possess several PKC isoforms which, except PKCzeta, were differentially down-regulated by TPA (PKCalpha, betaII, delta, epsilon, eta) or GnRH (PKCbetaII, delta, epsilon, eta). In spite of the presence of PKC inhibitors or down-regulation of PKC isoforms by TPA, the desensitizing effect of the neuropeptide on

  15. [Standardization of the quantitative flow cytometric test with anti-D antibodies for fetomaternal hemorrhage in RhD negative women].

    Science.gov (United States)

    Spychalska, Justyna; Uhrynowska, Małgorzata; Pyl, Hanna; Klimczak-Jajor, Edyta; Kopeć, Izabella; Peciakowska, Małgorzata; Gutowska, Renata; Gawlak, Maciej; Słomska, Sylwia; Dąbkowska, Syiwia; Szczecina, Roman; Dębska, Marzena; Brojer, Ewa

    2015-07-01

    In order to determine the appropriate dose of anti-D immunoglobulin to be administered as a preventive measure against hemolytic disease of the fetus/newborn in the subsequent pregnancy it is necessary to assess the number of fetal red blood cells that infiltrate/penetrate into the maternal circulation as a result of fetomaternal hemorrhage (FMH). One of the quantitative methods of FMH analysis is based on flow cytometry (FACS) which makes use of monoclonal antibodies to RhD antigen (anti-D test). The aim of the study was to further develop the method, evaluate its sensitivity and reproducibility and to compare it with the test based on the detection of fetal hemoglobin (HbF). The FACS study involved 20 RhD negative pregnant women and 80 RhD negative women after delivery. The following monoclonal antibodies were used: BRAD 3 FITC (anti-RhD antigen), CD45 PerCP (anti leukocyte antigen CD45), and anti-HbF PE. The fluorescence intensity of cells incubated with BRAD 3 FITC was demonstrated to depend on the RhD antigen expression, though the anti-D test also detects the weak D variant. The CD45 PerCP antibodies increased the sensitivity of anti-D test since they eliminated the leukocytes which non-specifically bind anti-D from the analysis. The presence of anti-D antibodies in maternal plasma does not affect the quantitative assessment of the fetal RhD positive fetal cells with BRAD 3 FITC. In case of FMH, the results of the anti-D test were similar to those with anti-HbF antibodies. The flow cytometric test with anti-D and anti-CD45 is useful in the assessment of the fetomaternal hemorrhage in RhD negative women. The sensitivity of the test is estimated at 0.05%.

  16. Ethylene decomposition on Rh(100): theory and experiment

    NARCIS (Netherlands)

    Nieskens, D.L.S.; Bavel, van A.P.; Curulla Ferre, D.; Niemantsverdriet, J.W.

    2004-01-01

    The decompn. of ethylene on a Rh(100) single crystal has been studied by a combination of exptl. techniques: static secondary ion mass spectrometry (SSIMS), temp.-programmed desorption (TPD), LEED, and high-resoln. electron energy loss spectroscopy (HREELS), to gain insight into the nature of the

  17. The Rh = ct universe in alternative theories of gravity

    Science.gov (United States)

    Sultana, Joseph; Kazanas, Demosthenes

    2017-12-01

    The Λ cold dark matter (ΛCDM) model (one comprising of a cosmological constant Λ and cold dark matter) is generally considered the standard model in cosmology. One of the alternatives that has received attention in the last few years is the Rh = ct universe, which provides an age for the Universe similar to that of ΛCDM and whose (vanishing) deceleration parameter is apparently not inconsistent with observations. Like the ΛCDM, the Rh = ct universe is based on a Friedmann-Robertson-Walker cosmology with the total energy density ρ and pressure p of the cosmic fluid satisfying the simple equation of state ρ + 3p = 0, i.e. a vanishing total active gravitational mass. In an earlier paper, we examined the possible sources for the Rh = ct universe within general relativity, and we have shown that it still contains a dark energy component, albeit not in the form of a cosmological constant. The growing interest in gravitational theories, alternative to Einstein's general relativity, in cosmology, is mainly driven by the need for cosmological models that attain a late-time accelerated expansion without the presence of a cosmological constant as in the ΛCDM, and thereby avoiding the problems associated with it. In this paper, we discuss some of these common alternative theories and show that the Rh = ct is also a solution to some of them.

  18. The Disintegration of {sup 103}Rh{sup m}

    Energy Technology Data Exchange (ETDEWEB)

    Czock, K. H.; Haselberger, N.; Reichel, F. [International Atomic Energy Agency, Vienna (Austria)

    1974-09-15

    A technique for determination of the disintegration rate of {sup 103}Rh{sup m} in thick foils is described. In addition values for the following parameters were determined: - total internal conversion coefficient {alpha} = 1531 {+-} 30; - K shell internal conversion coefficient {alpha}{sub K} = 127 {+-} 6; - conversion ratio R= K/L+M+..... = 0.0914 {+-} 0.0043. (author)

  19. Altering properties of cerium oxide thin films by Rh doping

    International Nuclear Information System (INIS)

    Ševčíková, Klára; Nehasil, Václav; Vorokhta, Mykhailo; Haviar, Stanislav; Matolín, Vladimír

    2015-01-01

    Highlights: • Thin films of ceria doped by rhodium deposited by RF magnetron sputtering. • Concentration of rhodium has great impact on properties of Rh–CeO x thin films. • Intensive oxygen migration in films with low concentration of rhodium. • Oxygen migration suppressed in films with high amount of Rh dopants. - Abstract: Ceria containing highly dispersed ions of rhodium is a promising material for catalytic applications. The Rh–CeO x thin films with different concentrations of rhodium were deposited by RF magnetron sputtering and were studied by soft and hard X-ray photoelectron spectroscopies, Temperature programmed reaction and X-ray powder diffraction techniques. The sputtered films consist of rhodium–cerium mixed oxide where cerium exhibits a mixed valency of Ce 4+ and Ce 3+ and rhodium occurs in two oxidation states, Rh 3+ and Rh n+ . We show that the concentration of rhodium has a great influence on the chemical composition, structure and reducibility of the Rh–CeO x thin films. The films with low concentrations of rhodium are polycrystalline, while the films with higher amount of Rh dopants are amorphous. The morphology of the films strongly influences the mobility of oxygen in the material. Therefore, varying the concentration of rhodium in Rh–CeO x thin films leads to preparing materials with different properties

  20. Isomer 103Rh excitation in the electron beam

    International Nuclear Information System (INIS)

    Alpatov, V.G.; Berezkin, V.V.; Vysotskij, S.A.

    1993-01-01

    Rhodium foil targets were irradiated by a beam of electrons from a linear accelerator containing a minor impurity of bremsstrahlung. X-ray and γ-quanta from decay of 103m Rh isomer states were detected. The ratio of isomer cross section activation by bremsstrahlung, formed in the target, and electrons, equals 89. 7 refs.; 3 figs.; 2 tabs

  1. Thermodynamics of Rh nuclear spins calculated by exact diagonalization

    DEFF Research Database (Denmark)

    Lefmann, K.; Ipsen, J.; Rasmussen, F.B.

    2000-01-01

    We have employed the method of exact diagonalization to obtain the full-energy spectrum of a cluster of 16 Rh nuclear spins, having dipolar and RK interactions between first and second nearest neighbours only. We have used this to calculate the nuclear spin entropy, and our results at both positi...

  2. NdRhSn: A ferromagnet with an antiferromagnetic precursor

    Czech Academy of Sciences Publication Activity Database

    Mihalik, M.; Prokleška, J.; Kamarád, Jiří; Prokeš, K.; Isnard, O.; McIntyre, G. J.; Dönni, A.; Yoshii, S.; Kitazawa, H.; Sechovský, V.; de Boer, F.R.

    2011-01-01

    Roč. 83, č. 10 (2011), "104403-1"-"104403-10" ISSN 1098-0121 R&D Projects: GA ČR GA202/09/1027 Institutional research plan: CEZ:AV0Z10100521 Keywords : NdRhSn * ferromagnet * antiferromagnetic precursor Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.691, year: 2011

  3. Frequency distribution 0f ABO, RH blood groups and blood ...

    African Journals Online (AJOL)

    One hundred and fifty students (150) were randomly selected from the Department of Cell Biology and Genetics of University of Lagos, Akoka, Nigeria for ABO, RH blood groups and 6 haemoglobin genotypes studies. Blood group O was the highest with the percentage frequency of 55.3%, followed by blood group A (25.3%) ...

  4. Itinerant magnetism in CeRh3B2

    DEFF Research Database (Denmark)

    Eriksson, Olle; Johansson, Börje; Brooks, M. S. S.

    1989-01-01

    Spin-polarized energy-band calculations, including spin-orbit coupling in the band Hamiltonian, have been performed on CeRh3B2. Good agreement is obtained between theory and experiment concerning the magnetic moment. It is also found that the magnetic moment varies strongly with volume and from...

  5. Performance based regulation - The maintenance rule

    Energy Technology Data Exchange (ETDEWEB)

    Correia, Richard P. [NRR/DOTS/TQMP, U.S. Nuclear Regulatory Commission, Office of Nuclear Reactor Regulation, M/S OWFN 10A19, Washington, D.C. 20555 (United States)

    1997-07-01

    The U.S. Nuclear Regulatory Commission has begun a transition from 'process-oriented' to 'results-oriented' regulations. The maintenance rule is a results-oriented rule that mandates consideration of risk and plant performance. The Maintenance Rule allows licensees to devise the most effective and efficient means of achieving the results described in the rule including the use of Probabilistic Risk (or Safety) Assessments. The NRC staff conducted a series of site visits to evaluate implementation of the Rule. Conclusions from the site visits indicated that the results-oriented Maintenance Rule can be successfully implemented and enforced. (author)

  6. Performance based regulation - The maintenance rule

    International Nuclear Information System (INIS)

    Correia, Richard P.

    1997-01-01

    The U.S. Nuclear Regulatory Commission has begun a transition from 'process-oriented' to 'results-oriented' regulations. The maintenance rule is a results-oriented rule that mandates consideration of risk and plant performance. The Maintenance Rule allows licensees to devise the most effective and efficient means of achieving the results described in the rule including the use of Probabilistic Risk (or Safety) Assessments. The NRC staff conducted a series of site visits to evaluate implementation of the Rule. Conclusions from the site visits indicated that the results-oriented Maintenance Rule can be successfully implemented and enforced. (author)

  7. The utility of the gonadotrophin releasing hormone (GnRH) test in the diagnosis of polycystic ovary syndrome (PCOS).

    Science.gov (United States)

    Lewandowski, Krzysztof C; Cajdler-Łuba, Agata; Salata, Ireneusz; Bieńkiewicz, Małgorzata; Lewiński, Andrzej

    2011-01-01

    Polycystic ovary syndrome (PCOS) is characterised by increased frequency of hypothalamic GnRH pulses leading to a relative increase in LH synthesis by the pituitary. As GnRH stimulation can reveal a relative LH excess, we have endeavoured to assess whether GnRH test might be useful in the diagnosis of PCOS. The study involved 185 subjects: a PCOS group, n = 151, all with oligo- or amenorrhoea, aged (mean ± SD) 24.8 ± ± 5.4 years, BMI 24.5 ± 6.0 kg/m²; and regularly menstruating controls, n = 34, aged 26.6 ± 5.0 years, BMI 24.6 ± 5.5 kg/m². In 121 subjects with PCOS and in 32 controls, serum LH and FSH were measured before (0 minutes) and 30 and 60 minutes after GnRH stimulation (100 μg i.v.). Insulin resistance was assessed by HOMA and Insulin Resistance Index derived from glucose and insulin concentrations during 75 gram oral glucose tolerance test. Women with PCOS had higher testosterone (p = 0.0002), androstendione (p = 0.0021), 17OH-progesterone (p PCOS. Baseline and stimulated LH concentrations were higher in PCOS (9.09 ± 5.56 vs 4.83 ± 1.71 IU/L, 35.48 ± 31.4 vs 16.30 ± 6.68 IU/L, 33.86 ± 31.8 vs 13.45 ± 5.2 IU/L, at 0, 30 and 60 mins post GnRH, respectively, p PCOS in comparison to controls (LH0 min/FSH(₀ min) 1.59 ± 0.95 vs 0.76 ± 0.2, LH(₃₀ min) /FSH(₃₀ min) 4.07 ± 3.0 vs 1.89 ± 0.79, LH(₆₀ min)/FSH(₆₀ min) 3.56 ± 2.58 vs 1.55 ± 0.63, p 2.11 or LH(₆₀ min)/FSH(₆₀ min) > 1.72 had 78.3% and 87.5% sensitivity and 81.7% and 81.3% specificity for the diagnosis of PCOS, respectively. Women with PCOS have higher baseline and GnRH-stimulated LH concentrations. GnRH stimulation results in an increase in LH/FSH ratio in women with PCOS. Therefore we postulate that this phenomenon might be potentially useful as an additional tool in the diagnosis of PCOS.

  8. Program integration of predictive maintenance with reliability centered maintenance

    International Nuclear Information System (INIS)

    Strong, D.K. Jr; Wray, D.M.

    1990-01-01

    This paper addresses improving the safety and reliability of power plants in a cost-effective manner by integrating the recently developed reliability centered maintenance techniques with the traditional predictive maintenance techniques of nuclear power plants. The topics of the paper include a description of reliability centered maintenance (RCM), enhancing RCM with predictive maintenance, predictive maintenance programs, condition monitoring techniques, performance test techniques, the mid-Atlantic Reliability Centered Maintenance Users Group, test guides and the benefits of shared guide development

  9. A practical procedure for the selection of time-to-failure models based on the assessment of trends in maintenance data

    International Nuclear Information System (INIS)

    Louit, D.M.; Pascual, R.; Jardine, A.K.S.

    2009-01-01

    Many times, reliability studies rely on false premises such as independent and identically distributed time between failures assumption (renewal process). This can lead to erroneous model selection for the time to failure of a particular component or system, which can in turn lead to wrong conclusions and decisions. A strong statistical focus, a lack of a systematic approach and sometimes inadequate theoretical background seem to have made it difficult for maintenance analysts to adopt the necessary stage of data testing before the selection of a suitable model. In this paper, a framework for model selection to represent the failure process for a component or system is presented, based on a review of available trend tests. The paper focuses only on single-time-variable models and is primarily directed to analysts responsible for reliability analyses in an industrial maintenance environment. The model selection framework is directed towards the discrimination between the use of statistical distributions to represent the time to failure ('renewal approach'); and the use of stochastic point processes ('repairable systems approach'), when there may be the presence of system ageing or reliability growth. An illustrative example based on failure data from a fleet of backhoes is included.

  10. A practical procedure for the selection of time-to-failure models based on the assessment of trends in maintenance data

    Energy Technology Data Exchange (ETDEWEB)

    Louit, D.M. [Komatsu Chile, Av. Americo Vespucio 0631, Quilicura, Santiago (Chile)], E-mail: rpascual@ing.puc.cl; Pascual, R. [Centro de Mineria, Pontificia Universidad Catolica de Chile, Av. Vicuna Mackenna 4860, Santiago (Chile); Jardine, A.K.S. [Department of Mechanical and Industrial Engineering, University of Toronto, 5 King' s College Road, Toronto, Ont., M5S 3G8 (Canada)

    2009-10-15

    Many times, reliability studies rely on false premises such as independent and identically distributed time between failures assumption (renewal process). This can lead to erroneous model selection for the time to failure of a particular component or system, which can in turn lead to wrong conclusions and decisions. A strong statistical focus, a lack of a systematic approach and sometimes inadequate theoretical background seem to have made it difficult for maintenance analysts to adopt the necessary stage of data testing before the selection of a suitable model. In this paper, a framework for model selection to represent the failure process for a component or system is presented, based on a review of available trend tests. The paper focuses only on single-time-variable models and is primarily directed to analysts responsible for reliability analyses in an industrial maintenance environment. The model selection framework is directed towards the discrimination between the use of statistical distributions to represent the time to failure ('renewal approach'); and the use of stochastic point processes ('repairable systems approach'), when there may be the presence of system ageing or reliability growth. An illustrative example based on failure data from a fleet of backhoes is included.

  11. Space station orbit maintenance

    Science.gov (United States)

    Kaplan, D. I.; Jones, R. M.

    1983-01-01

    The orbit maintenance problem is examined for two low-earth-orbiting space station concepts - the large, manned Space Operations Center (SOC) and the smaller, unmanned Science and Applications Space Platform (SASP). Atmospheric drag forces are calculated, and circular orbit altitudes are selected to assure a 90 day decay period in the event of catastrophic propulsion system failure. Several thrusting strategies for orbit maintenance are discussed. Various chemical and electric propulsion systems for orbit maintenance are compared on the basis of propellant resupply requirements, power requirements, Shuttle launch costs, and technology readiness.

  12. Maintenance optimization after RCM

    International Nuclear Information System (INIS)

    Doyle, E.K.; Lee, C.-G.; Cho, D.

    2005-01-01

    Variant forms of RCM (Reliability Centered Maintenance) have been the maintenance optimizing tools of choice in industry for the last 20 years. Several such optimization techniques have been implemented at the Bruce Nuclear Station. Further cost refinement of the Station preventive maintenance strategy whereby decisions are based on statistical analysis of historical failure data are now being evaluated. The evaluation includes a requirement to demonstrate that earlier optimization projects have long term positive impacts. This proved to be a significant challenge. Eventually a methodology was developed using Crowe/AMSAA (Army Materials Systems Analysis Activity) plots to justify expenditures on further optimization efforts. (authors)

  13. Nuclear power plants maintenance

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    Nuclear power plants maintenance now appears as an important factor contributing to the competitivity of nuclea energy. The articles published in this issue describe the way maintenance has been organized in France and how it led to an actual industrial activity developing and providing products and services. An information note about Georges Besse uranium enrichment plant (Eurodif) recalls that maintenance has become a main data not only for power plants but for all nuclear industry installations. (The second part of this dossier will be published in the next issue: vol. 1 January-February 1989) [fr

  14. Mobile network maintenance (GSM)

    CERN Multimedia

    IT Department

    2009-01-01

    Maintenance work will be carried out on the CERN mobile network infrastructure (GSM) on the 23 and 24 July from 6 p.m. to 6 a.m. in order to replace discontinued equipment and to increase the bandwidth capacity of the GSM mobile network. All CERN GSM emitters (40 units) will be moved one by one to the new infrastructure during the maintenance. The call of a user connected to an emitter at the time of its maintenance will be cut off. However, the general overlapping of the GSM radio coverage should mean that users are able immediately to call again should their call be interrupted. IT/CS/CS

  15. Initiating statistical maintenance optimization

    International Nuclear Information System (INIS)

    Doyle, E. Kevin; Tuomi, Vesa; Rowley, Ian

    2007-01-01

    Since the 1980 s maintenance optimization has been centered around various formulations of Reliability Centered Maintenance (RCM). Several such optimization techniques have been implemented at the Bruce Nuclear Station. Further cost refinement of the Station preventive maintenance strategy includes evaluation of statistical optimization techniques. A review of successful pilot efforts in this direction is provided as well as initial work with graphical analysis. The present situation reguarding data sourcing, the principle impediment to use of stochastic methods in previous years, is discussed. The use of Crowe/AMSAA (Army Materials Systems Analysis Activity) plots is demonstrated from the point of view of justifying expenditures in optimization efforts. (author)

  16. Intravenous immunoglobulin in ABO and Rh hemolytic diseases of newborn.

    Science.gov (United States)

    Nasseri, Fatemeh; Mamouri, Gholam A; Babaei, Homa

    2006-12-01

    To evaluate whether the use of intravenous immunoglobulin in newborn infants with isoimmune hemolytic jaundice due to Rh and ABO incompatibility is an effective treatment in reducing the need for exchange transfusion. This study included all direct Coombs' test positive Rh and ABO isoimmunized babies, who admitted in the Neonatal Intensive Care Unit of Ghaem Hospital of Mashhad University of Medical Sciences, Iran, from October 2003 to October 2004. Significant hyperbilirubinemia was defined as rising by >or=0.5 mg/dl per hour. Babies were randomly assigned to received phototherapy with intravenous immunoglobulin (IVIg) 0.5 g/kg over 4 hours, every 12 hours for 3 doses (study group) or phototherapy alone (control group). Exchange transfusion was performed in any group if serum bilirubin exceeded >or=20mg/dl or rose by >or=1mg/dl/h. A total of 34 babies were eligible for this study (17 babies in each group). The number of exchange transfusion, duration of phototherapy and hospitalization days, were significant shorter in the study group versus control group. When we analyzed the outcome results in ABO and Rh hemolytic disease separately, the efficacy of IVIg was significantly better in Rh versus ABO isoimmunization. Late anemia was more common in the IVIg group 11.8% versus 0%, p=0.48. Adverse effects were not observed during IVIg administration. Administration of IVIg to newborns with significant hyperbilirubinemia due to Rh hemolytic disease reduced the need for exchange transfusion but in ABO hemolytic disease there was no significant difference between IVIg and double surface blue light phototherapy.

  17. Evaluations of maintenance effectiveness on unavailability and risk

    International Nuclear Information System (INIS)

    Vesely, W.E.

    1993-01-01

    A methodology is presented for quantifying the effectiveness of maintenance on unavailability and on risk. The methodology is based on standard Markov modeling principles. What is new is the application to quantify maintenance effectiveness by explicitly quantifying maintenance benefits as well as maintenance's negative contributions. Maintenance effects are quantified by defining a degraded state for the component in addition to an operational state and a failed state which are usually defined. The maintenance model which is developed is a natural extension of the standard models used in reliability analysis and in Probabilistic Risk Assessments (PRAs). The results which are obtained can be directly used in PRAs. Applications of the methodology are presented by quantifying maintenance effectiveness on component performance and component unavailability for specific maintenance schedules

  18. Probing the interaction of Rh, Co and bimetallic Rh-Co nanoparticles with the CeO2 support: catalytic materials for alternative energy generation.

    Science.gov (United States)

    Varga, E; Pusztai, P; Óvári, L; Oszkó, A; Erdőhelyi, A; Papp, C; Steinrück, H-P; Kónya, Z; Kiss, J

    2015-10-28

    The interaction of CeO2-supported Rh, Co and bimetallic Rh-Co nanoparticles, which are active catalysts in hydrogen production via steam reforming of ethanol, a process related to renewable energy generation, was studied by X-ray diffraction (XRD), high resolution electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and low energy ion scattering (LEIS). Furthermore, diffuse reflectance infrared spectroscopy (DRIFTS) of adsorbed CO as a probe molecule was used to characterize the morphology of metal particles. At small loadings (0.1%), Rh is in a much dispersed state on ceria, while at higher contents (1-5%), Rh forms 2-8 nm particles. Between 473-673 K pronounced oxygen transfer from ceria to Rh is observed and at 773 K significant agglomeration of Rh occurs. On reduced ceria, XPS indicates a possible electron transfer from Rh to ceria. The formation of smaller ceria crystallites upon loading with Co was concluded from XRD and HRTEM; for 10% Co, the CeO2 particle size decreased from 27.6 to 10.7 nm. A strong dissolution of Co into ceria and a certain extent of encapsulation by ceria were deduced by XRD, XPS and LEIS. In the bimetallic system, the presence of Rh enhances the reduction of cobalt and ceria. During thermal treatments, reoxidation of Co occurs, and Rh agglomeration as well as oxygen migration from ceria to Rh are hindered in the presence of cobalt.

  19. Plant Maintenance. The Licensee's Viewpoint

    Energy Technology Data Exchange (ETDEWEB)

    Ungi, T. [Heysham 2 Power Station, Nuclear Electric LTD (United Kingdom)

    1997-07-01

    Plant maintenance is a very complex process which requires considerable effort from both within the maintenance process and also many support activities. It is important that the plant maintenance policy is translated into a maintenance programme which will define all relevant aspects of the maintenance. An aspect of this maintenance programme will be a maintenance catalogue which will define the maintenance activities to be carried out and at what frequencies. This paper is aimed at discussing the maintenance philosophy and resulting maintenance catalogues currently adopted in Nuclear Electric Ltd, and in particular at Heysham 2 Power Station. It goes on to consider whether these maintenance catalogues contain the optimum maintenance and if not should they be changed. If change is required, the process by which this change will be brought about is also discussed. (author)

  20. Experts' meeting: Maintenance '83

    International Nuclear Information System (INIS)

    1983-01-01

    The brochure presents, in full wording, 20 papers read at the experts' meeting ''Maintenance '83'' in Wiesbaden. Most of the papers discuss reliability data (acquisition, evaluation, processing) of nearly all fields of industry. (RW) [de

  1. Excellence through maintenance mastering

    International Nuclear Information System (INIS)

    Lamarche, M.; Guillot, M.; Monier, M.

    1987-01-01

    To improve the overall availability factor of nuclear power plants you have to cut either the forced outage role and the planned outage time or you need to reduce simultaneously the failures and the efforts devoted to avoiding them. Among other results, this goal leads to a decrease in the number of real or anticipated problems. Electricite de France policy, in this matter, is to focus on decreasing the compoents' maintenance needs through a comprehensive modification program, targeted to eliminating the weak points as revealed by the operation. Thereby one may reach, for simple equipment, a nearly maintenance-free condition in which the only maintenance needed is surveillance, which provides assurance that everything is operating properly. A good example of this type of equipment is the family of static components, drums, and pipes whose corrective maintenance is almost nil when their initial condition is good

  2. Nutritional status of maintenance dialysis patients

    DEFF Research Database (Denmark)

    Koefoed, Mette Juul; Kromann, Charles Boy; Juliussen, Sophie Ryberg

    2016-01-01

    Background and Aims Maintenance dialysis patients are at increased risk of abnormal nutritional status due to numerous causative factors, both nutritional and non-nutritional. The present study assessed the current prevalence of protein-energy wasting, low lean bodymass index and obesity...... protein catabolic rate in order to assess the prevalence of protein-energy wasting, low lean body mass index and obesity in these patients. Results Seventy-nine eligible maintenance dialysis patients participated. The prevalence of proteinenergy wasted patients was 4%(95%CI: 2-12) as assessed......-energy wasting and obesity varied considerably, depending on nutritional assessment methodology. Conclusions Our data indicate that protein-energy wasting is uncommon, whereas low lean body mass index and obesity are frequent conditions among patients in maintenance dialysis. A focus on how to increase...

  3. Applying principles of Design For Assembly to ITER maintenance operations

    International Nuclear Information System (INIS)

    Heemskerk, Cock; de Baar, Marco; Elzendoorn, Ben; Koning, Jarich; Verhoeven, Toon; Vreede, Fred de

    2009-01-01

    In ITER, maintenance operations in the vessel and in the Hot Cell will be largely done by Remote Handling (RH). Remotely performed maintenance actions tend to be more time-costly than actions performed by direct human access. With a human operator in the control loop and adequate situational feedback, a two-armed master slave manipulator system can mimic direct access with dexterous manipulation, tactile feedback and vision. But even then, turnaround times are still very high. Adapting the design for simplified maintenance operations can yield significant time savings. One of the methods known to produce a simpler, more robust design, which is also better suited for handling with robots, is Design For Assembly (DFA). This paper discusses whether and how the principles of DFA can be applied to simplify maintenance operations for ITER. While DFA is normally used with series-production and ITER is a unique product, it is possible to apply the principles of DFA to ITER maintenance operations. Furthermore, DFA's principles can be applied at different abstraction levels. Combining principles of DFA with Virtual Reality leads to new insights and provides additional value.

  4. Remote maintenance development

    International Nuclear Information System (INIS)

    Zook, C.R.

    1979-01-01

    The concept of remote maintenance as it pertains to nuclear fuel fabrication facilities is quite unique. The future may require completely remote facilities where maintenance will be performed by hybrid manipulators/robots. These units will be capable of being preprogrammed for automatic operation or manually operated with the operator becoming a part of the closed loop control system. These robots will mesh television, computer control, and direct force feedback manual control in a usable new concept of robotics

  5. Predictive maintenance primer

    International Nuclear Information System (INIS)

    Flude, J.W.; Nicholas, J.R.

    1991-04-01

    This Predictive Maintenance Primer provides utility plant personnel with a single-source reference to predictive maintenance analysis methods and technologies used successfully by utilities and other industries. It is intended to be a ready reference to personnel considering starting, expanding or improving a predictive maintenance program. This Primer includes a discussion of various analysis methods and how they overlap and interrelate. Additionally, eighteen predictive maintenance technologies are discussed in sufficient detail for the user to evaluate the potential of each technology for specific applications. This document is designed to allow inclusion of additional technologies in the future. To gather the information necessary to create this initial Primer the Nuclear Maintenance Applications Center (NMAC) collected experience data from eighteen utilities plus other industry and government sources. NMAC also contacted equipment manufacturers for information pertaining to equipment utilization, maintenance, and technical specifications. The Primer includes a discussion of six methods used by analysts to study predictive maintenance data. These are: trend analysis; pattern recognition; correlation; test against limits or ranges; relative comparison data; and statistical process analysis. Following the analysis methods discussions are detailed descriptions for eighteen technologies analysts have found useful for predictive maintenance programs at power plants and other industrial facilities. Each technology subchapter has a description of the operating principles involved in the technology, a listing of plant equipment where the technology can be applied, and a general description of the monitoring equipment. Additionally, these descriptions include a discussion of results obtained from actual equipment users and preferred analysis techniques to be used on data obtained from the technology. 5 refs., 30 figs

  6. Maintenance of scientific instruments

    International Nuclear Information System (INIS)

    Lucero, E.

    1986-01-01

    During the last years Colombia has increased the use of nuclear techniques, instruments and equipment in ambitious health programs, as well as in research centers, industry and education; this has resulted in numerous maintenance problems. As an alternative solution IAN has established a Central Maintenance Laboratory for nuclear instruments within an International Atomic Energy Agency program for eight Latin American and nine Asian Countries. Established strategies and some results are detailed in this writing

  7. Spectroscopy of the odd-odd chiral candidate nucleus 102Rh

    Directory of Open Access Journals (Sweden)

    Yavahchova M.S.

    2014-03-01

    Full Text Available Excited states in 102Rh were populated in the fusion-evaporation reaction 94Zr(11B, 3n102Rh at a beam energy of 36 MeV, using the INGA spectrometer at IUAC, New Delhi. The angular correlations and the electromagnetic character of some of the 03B3-ray transitions observed in 102Rh were investigated in detail. A new candidate for achiral twin band was identified in 102Rh for the first time.

  8. Mechanical configuration and maintenance

    International Nuclear Information System (INIS)

    Brown, T.G.; Casini, G.; Churakov, G.F.

    1982-01-01

    The INTOR engineering design has been strongly influenced by considerations for assembly and maintenance. A maintenance philosophy was established at the outset of the conceptual design to insure that the tokamak configuration would be developed to accommodate maintenance requirements. The main features of the INTOR design are summarized in this paper with primary emphasis on the impact of maintenance considerations. The most apparent configuration design feature is the access provided for torus maintenance. Particular attention was given to the size and location of superconducting magnets and the location of vacuum boundaries. All of the poloidal field (PF) coils are placed outside of the bore of the toroidal field (TF) coils and located above and below an access opening between adjacent TF coils through which torus sectors are removed. A magnet structural configuration consisting of mechanically attached reinforcing members has been designed which facilitates the open access space for torus sector removal. For impurity control, a single null poloidal divertor was selected over a double null design in order to maintain sufficient access for pumping and maintenance of the collector. A double null divertor was found to severely limit access to the torus with the addition of divertor collectors and pumping at the top. For this reason, a single null concept was selected in spite of the more difficult design problems associated with the required asymmetric PF system and higher particle loadings

  9. Principles of MONJU maintenance. Characteristic of MONJU maintenance and reflection of LWR maintenance experience to FBR

    International Nuclear Information System (INIS)

    Nakai, Satoru; Nishio, Ryuichi; Uchihashi, Masaya; Kaneko, Yoshihisa; Yamashita, Hironobu; Yamaguchi, Atsunori; Aoki, Takayuki

    2014-01-01

    A sodium cooled fast breeder reactor (FBR) has unique systems and components and different degradation mechanism from light water reactor (LWR) so that need to establish maintenance technology in accordance with its features. The examination of the FBR maintenance technology is carried out in the special committee for considering the maintenance for Monju established in the Japan Society of Maintenology (JSM). As a result of the study such as extraction of Monju maintenance feature, maintenance technology benchmark between Monju and LWR components and survey of LWR maintenance experience, it is clear that principles of maintenance are same as LWR, necessity of LWR maintenance experience reflection and points to be considered in Monju maintenance. The road map to establish a FBR maintenance technology in the technical aspect became clear and it is vital to acquire operation and maintenance experience of the plant to implement this road map, and to establish a fast reactor maintenance. (author)

  10. Induction of spermatogenesis and fertility in hypogonadotropic azoospermic men by intravenous pulsatile gonadotropin-releasing hormone (GnRH).

    Science.gov (United States)

    Blumenfeld, Z; Makler, A; Frisch, L; Brandes, J M

    1988-06-01

    Gonadotropin-releasing hormone (GnRH) has only recently become a helpful tool in the medication of hypogonadotropic hypogonadism (HH). Two azoospermic patients with HH who had previously been treated with hCG/hMG because of delayed puberty and each of whom had fathered a child after previous gonadotropin therapy were referred due to secondary failure of hCG/hMG treatment to induce spermatogenesis and fertility. A pulse study where blood was drawn every 15 minutes for LH, FSH and PRL RIAs was performed in each patient, and afterwards a bolus of i.v. GnRH was injected to assess gonadotropin responsiveness. A portable GnRH pump was connected to each patient so that it administered 5-20 micrograms of GnRH i.v. every 89 minutes. Spermatogenesis was first detected after 42 and 78 days respectively in the 2 treated HH men and 4 1/2 months from the start of treatment their wives became pregnant. No thrombophlebitis or other complications of the i.v. therapy occurred. In the case of the first patient, the semen was washed and concentrated and intra-uterine inseminations were carried out in an attempt to shorten the time needed to achieve fertility. The first pregnancy was successfully terminated at 38 weeks with the delivery of 2 heterozygotic normal male babies. The second pregnancy ended in spontaneous delivery of a healthy female. We conclude that i.v. pulsatile, intermittent GnRH administration is a safe, efficient and highly successful means of treating azoospermic men with HH.

  11. Effects of GnRH immunization in sexually mature pony stallions

    NARCIS (Netherlands)

    Turkstra, J.A.; Meer, F.J.U.M.; Knaap, J.; Rottier, P.J.M.; Teerds, K.J.; Colenbrander, B.; Meloen, R.H.

    2005-01-01

    Immunization against gonadotrophin releasing hormone (GnRH) was studied as an alternative for the commonly used surgical castration in stallions. Two GnRH vaccines comprising non-mineral oil adjuvants were evaluated for their potential to induce high antibody titers directed against GnRH and

  12. Prevalence of weak RhD phenotype in the blood donor population ...

    African Journals Online (AJOL)

    Background: The weak RhD phenotype is a form of RhD antigen that, in routine RhD typing, does not react by agglutination with potent monoclonal anti-D serum, but requires addition of antiglobulin serum to demonstrate the presence of the antigen. However, the weak D antigen can cause immunization or sensitization ...

  13. Hybridization and magnetism in U(Ru, Rh)X, X=Al, Ga

    NARCIS (Netherlands)

    Sechovsky, V.; Havela, L.; Boer, de F.R.; Veenhuizen, P.A.; Sugiyama, K.; Kuroda, T.; Sugiura, T.; Ono, M.; Date, M.; Yamagishi, A.

    1992-01-01

    Results of magnetic studies of pseudoternary U(Ru, Rh)Al and U(Ru, Rh)Ga systems are presented. Reduction of the 5f-4d hybridization with increasing Rh content is reflected in a gradual transition from paramagnetic (spin fluctuation) behaviour of URuX to ferromagnetism in URhX. The huge uniaxial

  14. Spectroscopic and DFT Study of RhIII Chloro Complex Transformation in Alkaline Solutions.

    Science.gov (United States)

    Vasilchenko, Danila B; Berdyugin, Semen N; Korenev, Sergey V; O'Kennedy, Sean; Gerber, Wilhelmus J

    2017-09-05

    The hydrolysis of [RhCl 6 ] 3- in NaOH-water solutions was studied by spectrophotometric methods. The reaction proceeds via successive substitution of chloride with hydroxide to quantitatively form [Rh(OH) 6 ] 3- . Ligand substitution kinetics was studied in an aqueous 0.434-1.085 M NaOH matrix in the temperature range 5.5-15.3 °C. Transformation of [RhCl 6 ] 3- into [RhCl 5 (OH)] 3- was found to be the rate-determining step with activation parameters of ΔH † = 105 ± 4 kJ mol -1 and ΔS † = 59 ± 10 J K -1 mol -1 . The coordinated hydroxo ligand(s) induces rapid ligand substitution to form [Rh(OH) 6 ] 3- . By simulating ligand substitution as a dissociative mechanism, using density functional theory (DFT), we can now explain the relatively fast and slow kinetics of chloride substitution in basic and acidic matrices, respectively. Moreover, the DFT calculated activation energies corroborated experimental data that the kinetic stereochemical sequence of [RhCl 6 ] 3- hydrolysis in an acidic solution proceeds as [RhCl 6 ] 3- → [RhCl 5 (H 2 O)] 2- → cis-[RhCl 4 (H 2 O) 2 ] - . However, DFT calculations predict in a basic solution the trans route of substitution [RhCl 6 ] 3- → [RhCl 5 (OH)] 3- → trans-[RhCl 4 (OH) 2 ] 3- is kinetically favored.

  15. Effective maintenance practices to manage system aging

    International Nuclear Information System (INIS)

    Chockie, A.; Bjorkelo, K.

    1992-01-01

    For a variety of economic and technical reasons, there has been a growing concern with the aging of complex systems and components and the role that maintenance can play in reducing this degradation. A study for the Nuclear Regulatory Commission was recently undertaken to identify effective maintenance practices that could be adapted by the nuclear industry in the United States to assist in managing the aging degradation of plant systems and components. Four organizations were examined to assess the influence that their maintenance programs have on their ability to address the systems and component aging degradation issues. An effective maintenance program was found to be essential to the management of system and component aging. The four key elements of an effective maintenance program that are important to an aging management program were identified. These are: the selection of critical systems and components; the development of an understanding of aging through the collection and analysis of equipment performance information; the development of appropriate preventive and predictive maintenance tasks to manage equipment and system aging degradation; the use of feedback mechanisms to continuously improve the management of aging systems and components. These elements were found to be common to all four organizations. In examining how the four organizations have structured their maintenance programs to include these key elements provides valuable lessons not only for the nuclear power industry, but also for any industrial organization that is concerned with the management of system and component aging degradation. This document provides detail, of these studies

  16. Implementation of maintenance rule for structures

    International Nuclear Information System (INIS)

    Ashar, H.; Bagchi, G.

    1999-01-01

    The maintenance rule, 10 CFR 50.65, 'Requirements for Monitoring the Effectiveness of Maintenance at Nuclear Power Plants', was published by the Nuclear Regulatory Commission (NRC) in the Federal Register (56 FR 31324) on July 10, 1991. The rule became effective on July 10, 1996, giving nuclear power plant licensees 5 years to implement it. During 1994-1995, NRC staff visited nine nuclear power plant sites to observe licensees' preparations for implementation of the rule. The teams found that most of the licensees had not established goals, or performance criteria for monitoring structures at their sites. The licensees contended that the structures were inherently reliable and required no monitoring under the maintenance rule. On the basis of earlier site visits performed by NRC staff to assess the condition of structures, the NRC staff could not accept this contention, and clarified its position in Revision 1 of Regulatory Guide 1.160, 'Monitoring the Effectiveness of Maintenance at Nuclear Power Plants'. This paper discusses the applicability of the maintenance rule criteria for structures and its usefulness in ensuring that the structures, systems, and components within the scope of the maintenance rule are capable of fulfilling their intended functions. Also discussed are the aspects of maintenance rule efforts that could be useful for license renewal applications. (orig.)

  17. Evaluation of 101Rh as a brachytherapy source

    Science.gov (United States)

    Ghorbani, Mahdi; Meigooni, Ali Soleimani

    2015-01-01

    Purpose Recently a number of hypothetical sources have been proposed and evaluated for use in brachytherapy. In the present study, a hypothetical 101Rh source with mean photon energy of 121.5 keV and half-life of 3.3 years, has been evaluated as an alternative to the existing high-dose-rate (HDR) sources. Dosimetric characteristics of this source model have been determined following the recommendation of the Task Group 43 (TG-43) of the American Association of the Physicist in Medicine (AAPM), and the results are compared with the published data for 57Co source and Flexisource 192Ir sources with similar geometries. Material and methods MCNPX Monte Carlo code was used for simulation of the 101Rh hypothetical HDR source design. Geometric design of this hypothetical source was considered to be similar to that of Flexisource 192Ir source. Task group No. 43 dosimetric parameters, including air kerma strength per mCi, dose rate constant, radial dose function, and two dimensional (2D) anisotropy functions were calculated for the 101Rh source through simulations. Results Air kerma strength per activity and dose rate constant for the hypothetical 101Rh source were 1.09 ± 0.01 U/mCi and 1.18 ± 0.08 cGy/(h.U), respectively. At distances beyond 1.0 cm in phantom, radial dose function for the hypothetical 101Rh source is higher than that of 192Ir. It has also similar 2D anisotropy functions to the Flexisource 192Ir source. Conclusions 101Rh is proposed as an alternative to the existing HDR sources for use in brachytherapy. This source provides medium energy photons, relatively long half-life, higher dose rate constant and radial dose function, and similar 2D anisotropy function to the Flexisource 192Ir HDR source design. The longer half-life of the source reduces the frequency of the source exchange for the clinical environment. PMID:26034499

  18. Building relationships for better maintenance.

    Science.gov (United States)

    Lee, Hackman Hon Yin; Scott, David

    2009-02-01

    Effective management of building maintenance is a vital ingredient in ensuring a high quality built environment for any building's occupiers. However, maintenance is not high on the list of priorities for most organisations. Communication between top management personnel looking at maintenance issues from a strategic standpoint and maintenance staff considering them at an operational level is often not as good as it should be. When planning maintenance activities maintenance personnel often draw too heavily on their technical experience and expertise without taking sufficient account of wider organisational objectives or consulting effectively with top management. Senior managers also regularly complain about lack of managerial input from maintenance departments. Such barriers contribute to communication difficulties between top management at a strategic level and maintenance personnel at an operational level. Identifying where the key differences lie in senior managers' and maintenance personnel's viewpoints on maintenance strategy can prove invaluable in achieving some convergence of opinions and optimising the efficiency of the overall building maintenance process.

  19. Frequency Distribution of Blood Groups ABO, MN and Rh Factor in Philippine Cosmopolitan, Regional and the National Populations

    OpenAIRE

    Ruth Marian S. Guzman; Ricardo Noel R. Gervasio; Ian Kendrich C. Fontanilla; Ernelea P. Cao

    2009-01-01

    Frequency distribution of blood groups is important as it is used in modern medicine, genetic research, anthropology, and tracing ancestral relations of humans. Blood groups include the ABO, Rh and the MN red cell antigens. The frequency distribution of these three blood groups were obtained and assessed for differences from three populations: (1) a regional population from the town of Cabagan located in Isabela province; (2) a cosmopolitan population from the University of the Philippines’ r...

  20. JRR-3 maintenance program utilizing accumulated maintenance data

    International Nuclear Information System (INIS)

    Izumo, Hironobu; Kato, Tomoaki; Kinase, Masami; Torii, Yoshiya; Murayama, Yoji

    2007-07-01

    JRR-3(Japan Research Reactor No.3) has been operated for more than 15 years after the modification, without significant troubles by carrying out maintenance such as the preventive maintenance (mainly time-based maintenance) for the safety-grade equipments and the breakdown maintenance for the non-safety-grade equipments. Unscheduled shutdowns causes by aged non-safety-grade equipments have been increasing, and the resources such as budgets have been decreasing year by year. In this situation, JRR-3 maintenance program was reviewed about safety, reliability and economic efficiency. This report offers the policy of the maintenance review and the future direction of maintenance programs. (author)

  1. Configuration management of on-line maintenance

    International Nuclear Information System (INIS)

    Grantom, C.R.

    1996-01-01

    Maintenance activities are performed on station equipment to ensure continued safe and reliable performance. Equipment reliability is thereby improved, resulting in greater confidence that the component will be capable of performing its intended (safety) function. Probabilistic Safety Assessments (PSAs) consider equipment reliability and availability to calculate Core Damage Frequency (CDF) and other risk-related values. Since maintenance activities are included in PSA analyses, the effect of equipment outages on CDF can be analyzed. Results from these types of studies can be scaled to reflect different time periods and show the time-dependent impact of planned equipment outages on CDF. These time-dependent impacts on CDF are graphically presented and referred to as ''risk profiles''. Risk profiles are being successfully used at the South Texas Project (STP) to plan preventive maintenance activities and to assess the impact of unplanned maintenance activities on plant safety. At STP, planned maintenance activities are scheduled to minimize the risk impact of unavailable equipment and to prevent the Occurrence of undesirable plant configurations. The features of the risk profiles used at STP enable the evaluation of both work scope and duration of maintenance activities to be evaluated. This is possible since the risk profile illustrates both instantaneous CDF effects and cumulative impacts to CDF

  2. Early implementation of the Maintenance Rule

    International Nuclear Information System (INIS)

    Green, J.R.

    1995-01-01

    On July 10, 1991, the U.S. Nuclear Regulatory Commission (NRC) published the Maintenance Rule as Section 50.65 of 10 CFR 50. The purpose of the Maintenance Rule is to ensure that the effectiveness of maintenance activities is assessed on an ongoing basis in a manner that ensures key structures, systems, and components are capable of performing their intended function. Full implementation of the rule is required by July 10, 1996. On May 31, 1994, the NRC published Generic Letter 94-01, which allowed removal of technical specification accelerated testing and special reporting requirements for emergency diesel generators provided a program is implemented for monitoring and maintaining emergency diesel generator performance consistent with the provisions of the Maintenance Rule

  3. A human factors approach to effective maintenance

    International Nuclear Information System (INIS)

    Penington, J.; Shakeri, S.

    2006-01-01

    Traditionally in the field of Human Factors within the nuclear industry, the focus has been to identify the potential for human errors in operating tasks, and develop strategies to prevent their occurrence, provide recovery mechanisms, and mitigate the consequences of error as appropriate. Past experience has demonstrated however a significant number of human errors within the nuclear industry occur during maintenance tasks. It is for this reason, and the fact that our nuclear power plants are ageing and increasingly in need of maintenance, that the industry must pay more attention to maintenance tasks. The purpose of this paper is to present a framework for effective maintenance programs, and based upon this framework discuss an approach (an audit tool) that can be used to both design such a program, and to assess existing programs. In addition, this tool can form the basis of cost benefit decisions relating to priorities for improvements to existing programs. (author)

  4. Stacking reactions of the borole complex Cp*Rh(η5-C4H4BPh) with the dicationic fragments [Cp*M]2+ (M = Rh or Ir)

    International Nuclear Information System (INIS)

    Loginov, D.A.; Muratov, D.V.; Starikova, Z.A.; Petrovskij, P.V.; Kudinov, A.R.

    2006-01-01

    The reaction of the (borole)rhodium iodide complex [(η-C 4 H 4 BPh)RhI] 4 with Cp*Li afforded the sandwich compound Cp*Rh(η-C 4 H 4 BPh) (1). The reactions of compound 1 with the solvated complexes [Cp*M(MeNO 2 ) 3 ] 2+ (BF 4 - ) 2 gave triple-decker cationic complexes with the central borole ligand [Cp*Rh(μ-η 5 :η 5 -C 4 H 4 BPh)MCp*] 2+ (BF 4 - ) 2 (M = Rh or Ir). The structure of complex 1 was established by X-ray diffraction [ru

  5. Quasi-two-dimensional Fermi-liquid state in Sr2RhO4-δ

    International Nuclear Information System (INIS)

    Nagai, Ichiro; Shirakawa, Naoki; Umeyama, Norio; Ikeda, Shin-ichi

    2010-01-01

    Single crystals of layered perovskite Sr 2 RhO 4-δ (δ=0.0 and 0.1) are successfully grown by the floating-zone method. Stoichiometric single crystals (Sr 2 RhO 4.0 ) are obtained by O 2 -annealing the as-grown crystals (Sr 2 RhO 3.9 ). Sr 2 RhO 4.0 and Sr 2 RhO 3.9 show quasi-two-dimensional Fermi-liquid behavior at low temperatures, whereas there are large differences in the anisotropy of electrical resistivity ρ c (3 K)/ρ ab (3 K) and Wilson ratio R w between Sr 2 RhO 4.0 and Sr 2 RhO 3.9 : ρ c (3 K)/ρ ab (3 K)=2400 (19000) and R w =3.8 (6.4) for Sr 2 RhO 4.0 (Sr 2 RhO 3.9 ). The differences observed between the temperature dependence of the in-plane electrical resistivity (T 2 RhO 4.0 and Sr 2 RhO 3.9 are mainly derived from those between the density of states and band structure near the corresponding Fermi level. This indicates that the changes in these physical properties, which are accompanied by oxygen defects in the Sr 2 RhO 4-δ system, can be explained by the rigid band model. Moreover, these results suggest that t 2g band-filling can be controlled by adjusting the oxygen defect content δ in the Sr 2 RhO 4-δ system. Although many similarities are observed in this study between the physical properties of Sr 2 RhO 4.0 and Sr 2 RuO 4 . Sr 2 RhO 4.0 does not exhibit superconductivity down to 36 mK. (author)

  6. Lattice dynamics of KxRhO2 single crystals

    Directory of Open Access Journals (Sweden)

    Bin-Bin Zhang

    2015-08-01

    Full Text Available A series of crystals KxRhO2 (x = 0.72, 0.63, 0.55, 0.39, and 0.24 have been synthesized and their vibrational properties have been studied by first principles calculations, Raman spectroscopy, and inelastic neutron scattering. The measured vibrational spectra of KxRhO2 for x = 0.72 and 0.63 are consistent with the theoretical prediction for the stoichiometric KRhO2. For samples with x = 0.55, 0.39 and 0.24, extra vibrational modes have been observed and they are believed to be due to the symmetry reduction and the loss of translational symmetry induced by K disorder. The good agreement was found for the phonon density of states among the Raman spectroscopic observations, inelastic neutron scattering and the first principles calculations, as an evidence for the generation of structure disorder by K deficiency.

  7. Antiferromagnetic ordering in GdRhIn{sub 5}

    Energy Technology Data Exchange (ETDEWEB)

    Latka, K.; Rams, M. [Marian Smoluchowski Inst. of Physics, Jagiellonian Univ., Krakow (Poland); Kmiec, R.; Pacyna, A.W. [Henryk Niewodniczanski Inst. of Nuclear Physics, Polish Academy of Sciences, Krakow (Poland); Zaremba, V.I. [Inorganic Chemistry Dept., Ivan Franko National Univ. of Lviv, Lviv (Ukraine); Inst. fuer Anorganische und Analytische Chemie, Westfaelische Wilhelms-Univ. Muenster (Germany); Poettgen, R. [Inst. fuer Anorganische und Analytische Chemie, Westfaelische Wilhelms-Univ. Muenster (Germany)

    2004-09-01

    A polycrystalline sample of tetragonal GdRhIn{sub 5} (HoCoGa{sub 5} type, space group P4/mmm) was obtained by induction melting of the elements in a glassy carbon crucible in a water-cooled sample chamber and subsequent annealing at 670 K. X-ray powder data yielded the cell parameters a = 460.65(7), c = 743.52(12) pm. The magnetic and electronic properties of GdRhIn{sub 5} have been studied by magnetic susceptibility, electrical resistivity, and {sup 155}Gd Moessbauer spectroscopic measurements. Antiferromagnetic ordering is detected at 41.0(2) K. The results are discussed using a simple molecular field approximation. (orig.)

  8. Guidelines for remote handling maintenance of ITER neutral beam line components: Proposal of an alternate supporting system

    International Nuclear Information System (INIS)

    Cordier, J.J.; Bayetti, P.; Hemsworth, R.; David, O.; Friconneau, J.P.

    2007-01-01

    Remote handling (R/H) maintenance of ITER components is one of the main challenges of the ITER project. This type of maintenance shall be operational for the assembly and nuclear phase of exploitation of ITER. It must be considered at a very early stage since it significantly impacts on the components design, interfaces management, assembly, maintenance and integration aspects. A large part of the R/H equipment will be procured by the EU Participating Team, including the whole Neutral Beam R/H Equipment. The Neutral Beam Heating and Current Drive system (NB and CD) design is being revisited by the ITER project. A vertical maintenance scheme is presently considered which may significantly impact on the reference design and associated components and lead to a new design of the NB and CD vacuum tank. In addition, NB line components remote handling solutions are being studied. The neutral beam test facility ITER to be built in Europe in the near future is also based on the vertical NB maintenance scheme of beam line components. New design guidelines compliant for both the ITER NB and CD system and the NB test facility proposed by the CEA association are described in the paper

  9. Use of cffDNA to avoid administration of anti-D to pregnant women when the fetus is RhD-negative: implementation in the NHS.

    Science.gov (United States)

    Soothill, P W; Finning, K; Latham, T; Wreford-Bush, T; Ford, J; Daniels, G

    2015-11-01

    To determine whether a policy of offering cffDNA testing to all RhD-negative women at about 16 weeks' gestation to avoid anti-D administration when the fetus is RhD-negative could be implemented successfully in the NHS without additional funding. Prospectively planned observational service implementation pilot and notes audit. Three maternity services in the South West of England. All RhD-negative women in a 6-month period. Prospective, intervention, cross-sectional observational study, using pre-intervention data as controls. Proportion of suitable women who offered and accepted the test. Accuracy of the cffDNA result as assessed by cord blood group result. Fall in anti-D doses administered. 529 samples were received; three were unsuitable. The results were reported as RhD-positive (n = 278), RhD-negative (n = 185) or inconclusive, treat as positive (n = 63). Cord blood results were available in 502 (95%) and the only incorrect result was one case of a false positive (cffDNA reported as positive, cord blood negative - and so given anti-D unnecessarily). The notes audit showed that women who declined this service were correctly managed and that anti-D was not given when the fetus was predicted to be RhD-negative. The total use of anti-D doses fell by about 29% which equated to about 35% of RhD-negative women not receiving anti-D in their pregnancy unnecessarily. We recommend this service is extended to all UK NHS services. © 2014 Royal College of Obstetricians and Gynaecologists.

  10. Comparative evaluation of remote maintenance schemes for fusion DEMO reactor

    Energy Technology Data Exchange (ETDEWEB)

    Utoh, Hiroyasu, E-mail: uto.hiroyasu@jaea.go.jp; Tobita, Kenji; Someya, Youji; Asakura, Nobuyuki; Sakamoto, Yoshiteru; Hoshino, Kazuo; Nakamura, Makoto

    2015-10-15

    Highlights: • Various remote maintenance schemes for DEMO were comparatively assessed based on requirements for DEMO remote maintenance. • The banana shape segment transport using all vertical maintenance ports would be more probable DEMO reactor maintenance scheme. • The key engineering issues are in-vessel transferring mechanism of segment, pipe connection and conducting shell design for plasma vertical stability. - Abstract: Maintenance schemes are one of the critical issues in DEMO design, significantly affecting the configuration of in-vessel components, the size of toroidal field (TF) coil, the arrangement of poloidal field (PF) coils, reactor building, hot cell and so forth. Therefore, the maintenance schemes should satisfy many design requirements and criteria to assure reliable and safe plant operation and to attain reasonable plant availability. The plant availability depends on reliability of remote maintenance scheme, inspection of pipe connection and plasma operation. In this paper, various remote maintenance schemes for DEMO were comparatively assessed based on requirements for DEMO remote maintenance. From the view points of the reliability of inspection on hot cell, TF coil size, stored energy of PF coil and portability of segment, the banana shape segment transport using all vertical maintenance ports would be more probable DEMO reactor maintenance scheme, and it has key engineering issues such as in-vessel transferring mechanism of segment, pipe connection and conducting shell design for plasma vertical stability.

  11. Comparative evaluation of remote maintenance schemes for fusion DEMO reactor

    International Nuclear Information System (INIS)

    Utoh, Hiroyasu; Tobita, Kenji; Someya, Youji; Asakura, Nobuyuki; Sakamoto, Yoshiteru; Hoshino, Kazuo; Nakamura, Makoto

    2015-01-01

    Highlights: • Various remote maintenance schemes for DEMO were comparatively assessed based on requirements for DEMO remote maintenance. • The banana shape segment transport using all vertical maintenance ports would be more probable DEMO reactor maintenance scheme. • The key engineering issues are in-vessel transferring mechanism of segment, pipe connection and conducting shell design for plasma vertical stability. - Abstract: Maintenance schemes are one of the critical issues in DEMO design, significantly affecting the configuration of in-vessel components, the size of toroidal field (TF) coil, the arrangement of poloidal field (PF) coils, reactor building, hot cell and so forth. Therefore, the maintenance schemes should satisfy many design requirements and criteria to assure reliable and safe plant operation and to attain reasonable plant availability. The plant availability depends on reliability of remote maintenance scheme, inspection of pipe connection and plasma operation. In this paper, various remote maintenance schemes for DEMO were comparatively assessed based on requirements for DEMO remote maintenance. From the view points of the reliability of inspection on hot cell, TF coil size, stored energy of PF coil and portability of segment, the banana shape segment transport using all vertical maintenance ports would be more probable DEMO reactor maintenance scheme, and it has key engineering issues such as in-vessel transferring mechanism of segment, pipe connection and conducting shell design for plasma vertical stability.

  12. The intermetallic ThRh5: microstructure and enthalpy increments

    International Nuclear Information System (INIS)

    Banerjee, Aparna; Joshi, A.R.; Kaity, Santu; Mishra, R.; Roy, S.B.

    2013-01-01

    Actinide intermetallics are one of the most interesting and important series of compounds. Thermochemistry of these compounds play significant role in understand the nature of bonding in alloys and nuclear fuel performance. In the present paper we report synthesis and characterization of thorium based intermetallic compound ThRh 5 (s) by SEM/EDX technique. The mechanical properties and enthalpy increment as a function of temperature of the alloy has been measured. (author)

  13. Maintenance for life management

    International Nuclear Information System (INIS)

    Hevia, F.

    1997-01-01

    Life Management is based on the detection, monitoring and control of long-term degradation that affects individual plant components and important populations. Experience has shown that in many cases current maintenance practices do not attend to ageing directly; instead they deal with the consequences when it is already too late, when good Life Management is no longer practical. This has brought about the need for specific Maintenance Evaluation and Improvement Programmes to adjust to the basic objective of Life Management which is to project against, monitor and mitigate ageing that can affect the safe and profitable operating life of the facility. New regulatory requirements for ageing monitoring and effective maintenance to ensure safety (Maintenance Rule) have made it even more necessary to implement the Maintenance Evaluation Programme to cope with ageing, and to integrate that tasks in both programmes to optimise effort and use of tools. This paper presents a brief description of the objectives and methodologies of these Programmes which has been applied to plants around the world and in Spain at the Garona and Vandellos II plants in Spain as part of the PIE project for developing a Remanent Life Evaluation System for nuclear power plants. (Author)

  14. A Stable Coordination Complex of Rh(IV) in an N,O-Donor Environment

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, Shashi B. [Department of Chemistry, Yale University, 225 Prospect; Shopov, Dimitar Y. [Department of Chemistry, Yale University, 225 Prospect; Sharninghausen, Liam S. [Department of Chemistry, Yale University, 225 Prospect; Vinyard, David J. [Department of Chemistry, Yale University, 225 Prospect; Mercado, Brandon Q. [Department of Chemistry, Yale University, 225 Prospect; Brudvig, Gary W. [Department of Chemistry, Yale University, 225 Prospect; Crabtree, Robert H. [Department of Chemistry, Yale University, 225 Prospect

    2015-12-10

    We describe facial and meridional isomers of [RhIII(pyalk)3], as well as meridional [RhIV(pyalk)3]+ {pyalk =2-(2-pyridyl)-2-propanoate}, the first coordination complex in an N,O-donor environment to show a clean, reversible RhIII/IV redox couple and to have a stable Rh(IV) form, which we characterize by EPR and UV–visible spectroscopy as well as X-ray crystallography. The unprecedented stability of the Rh(IV) species is ascribed to the exceptional donor strength of the ligands, their oxidation resistance, and the meridional coordination geometry.

  15. Building Maintenance, Management, and Budgeting.

    Science.gov (United States)

    Pawsey, M. R.

    1982-01-01

    Australian methods and formulas for funding building maintenance and management are outlined and found to be haphazard. Discussed are: ultimate costs of deferred maintenance, major plant replacements, life cycle costing, types of maintenance programs (including full preventive maintenance), use of computer programs for planning, and organization…

  16. Gama-gama angular correlations in the 105Rh nucleus

    International Nuclear Information System (INIS)

    Esteves, V.A.P.

    1979-01-01

    The Directional Correlation of γ transitions in 105 Rh have been measured from the β - decay of 105 Ru using a Ge(Li) - Nal(Tl) spectrometers. The measurements were carried out for the (316-469), (500-469), (845-499), (875-469), (878-499), (907-469), (1017-469), (350-326), (393-263), (413-263), (489-149) and (575-149) KeV gama cascades. The present results confirm the spin assignments to several levels in 105 Rh obtained in previous studies. The multipole mixing ratios Δ(E2/M1) for several gama transitions have been calculated from the measured angular correlations. The results are Δ(149)=0.34+-0.01,Δ(262)=-1.27+-0.02 or -0.14+-0.01,Δ(326)=-1.79+-0.01 or 0.014+-0.002, Δ(393)=-7.1+-0.3 or -0.36+-0.01, Δ(489)=0.25+-0.002, Δ(500)=0.7+-0.3 and Δ(907)=-21.7 +8 -31.1 or 0.21+-0.03. The structure of nuclear levels in 105 Rh is discussed briefly in terms of models applicable for nuclide in this mass region [pt

  17. GnRH-Analoga und Add-back-Verfahren

    Directory of Open Access Journals (Sweden)

    Kleinstein J

    2008-01-01

    Full Text Available GnRH-Analoga haben eine große Bedeutung in der medikamentösen Therapie der Endometriose erlangt. Sie sind in der Lage, Endometrioseassoziierte Schmerzen zu beseitigen und sind Bestandteil der Therapie der endometriosebedingten Infertilität. Aufgrund der Chronizität der Endometriose bedarf es in vielen Fällen der Prolongation der GnRH-A-Therapie über den Zeitraum von 6 Monaten hinaus. Für diese Fälle eignet sich eine Add-back- Therapie nach dem Format von Hormonersatztherapien, um vasomotorischen Nebeneffekten und dem Knochensubstanzverlust entgegenwirken zu können. Dabei wird der Estrogenanteil niedrig dosiert eingesetzt, um innerhalb eines "therapeutischen Fensters" den Hypoestrogenismus auszugleichen, ohne das Endometriosewachstum zu fördern. Prinzipiell kann dazu das Estrogen oral, aber auch transdermal appliziert werden. Die Effektivität der Kombination aus GnRH-A plus Add-back bezüglich der Knochenprotektion konnte bereits für einen Zeitraum von bis zu 10 Jahren bestätigt werden, sodass damit eine Langzeitkonzeption für Frauen mit rezidivierender Endometriose und wiederholten operativen Eingriffen existiert. Alternativen zur klassischen Add-back mit Sexualsteroiden existieren vielfältig, aber ihr Einsatz ist durch Partialwirkungen und eigene Nebenwirkungen limitiert.

  18. The MERC maintenance system

    International Nuclear Information System (INIS)

    Izquierdo, J.J.; Chauvire, P.; Plessis, L.

    1991-01-01

    Maintenance in the modern commercial reprocessing plants is a subject of the highest priority in order to guarantee availability for the whole life of the plant. The design concept of the UP3 reprocessing plant at La Hague identified several categories of equipment according to their maintenance design principles. Among them, Standard Process Equipment such as pumps, valves, ejectors and filters which need periodic maintenance. These equipment items are designed in removable modular form to avoid the need to disconnect piping. Removal is performed under shielding and without breach of containment through the use of a transfer cask that is connected to the cell containing the equipment to be removed. This transfer cask is called MERC (Mobile Equipment Replacement Cask). Containment is preserved by an air-tight system consisting of coupled doors, with a special connecting gasket. This system can remove and replace failed equipment, without spreading contamination to work areas. (author)

  19. Reliability Centered Maintenance - Methodologies

    Science.gov (United States)

    Kammerer, Catherine C.

    2009-01-01

    Journal article about Reliability Centered Maintenance (RCM) methodologies used by United Space Alliance, LLC (USA) in support of the Space Shuttle Program at Kennedy Space Center. The USA Reliability Centered Maintenance program differs from traditional RCM programs because various methodologies are utilized to take advantage of their respective strengths for each application. Based on operational experience, USA has customized the traditional RCM methodology into a streamlined lean logic path and has implemented the use of statistical tools to drive the process. USA RCM has integrated many of the L6S tools into both RCM methodologies. The tools utilized in the Measure, Analyze, and Improve phases of a Lean Six Sigma project lend themselves to application in the RCM process. All USA RCM methodologies meet the requirements defined in SAE JA 1011, Evaluation Criteria for Reliability-Centered Maintenance (RCM) Processes. The proposed article explores these methodologies.

  20. Computer assisted procedure maintenance

    International Nuclear Information System (INIS)

    Bisio, R.; Hulsund, J. E.; Nilsen, S.

    2004-04-01

    The maintenance of operating procedures in a NPP is a tedious and complicated task. Through the whole life cycle of the procedures they will be dynamic, 'living' documents. Several aspects of the procedure must be considered in a revision process. Pertinent details and attributes of the procedure must be checked. An organizational structure must be created and responsibilities allotted for drafting, revising, reviewing and publishing procedures. Available powerful computer technology provides solutions within document management and computerisation of procedures. These solutions can also support the maintenance of procedures. Not all parts of the procedure life cycle are equally amenable to computerized support. This report looks at the procedure life cycle in todays NPPs and discusses the possibilities associated with introduction of computer technology to assist the maintenance of procedures. (Author)

  1. Bone marrow concentrate promotes bone regeneration with a suboptimal-dose of rhBMP-2.

    Science.gov (United States)

    Egashira, Kazuhiro; Sumita, Yoshinori; Zhong, Weijian; I, Takashi; Ohba, Seigo; Nagai, Kazuhiro; Asahina, Izumi

    2018-01-01

    Bone marrow concentrate (BMC), which is enriched in mononuclear cells (MNCs) and platelets, has recently attracted the attention of clinicians as a new optional means for bone engineering. We previously reported that the osteoinductive effect of bone morphogenetic protein-2 (BMP-2) could be enhanced synergistically by co-transplantation of peripheral blood (PB)-derived platelet-rich plasma (PRP). This study aims to investigate whether BMC can effectively promote bone formation induced by low-dose BMP-2, thereby reducing the undesirable side-effects of BMP-2, compared to PRP. Human BMC was obtained from bone marrow aspirates using an automated blood separator. The BMC was then seeded onto β-TCP granules pre-adsorbed with a suboptimal-dose (minimum concentration to induce bone formation at 2 weeks in mice) of recombinant human (rh) BMP-2. These specimens were transplanted subcutaneously to the dorsal skin of immunodeficient-mice and the induction of ectopic bone formation was assessed 2 and 4 weeks post-transplantation. Transplantations of five other groups [PB, PRP, platelet-poor plasma (PPP), bone marrow aspirate (BM), and BM-PPP] were employed as experimental controls. Then, to clarify the effects on vertical bone augmentation, specimens from the six groups were transplanted for on-lay placement on the craniums of mice. The results indicated that BMC, which contained an approximately 2.5-fold increase in the number of MNCs compared to PRP, could accelerate ectopic bone formation until 2 weeks post-transplantation. On the cranium, the BMC group promoted bone augmentation with a suboptimal-dose of rhBMP-2 compared to other groups. Particularly in the BMC specimens harvested at 4 weeks, we observed newly formed bone surrounding the TCP granules at sites far from the calvarial bone. In conclusion, the addition of BMC could reduce the amount of rhBMP-2 by one-half via its synergistic effect on early-phase osteoinduction. We propose here that BMC transplantation

  2. Random-start GnRH antagonist for emergency fertility preservation: a self-controlled trial

    Directory of Open Access Journals (Sweden)

    Checa MA

    2015-02-01

    Full Text Available Miguel A Checa,1,2 Mario Brassesco,2 Margalida Sastre,1 Manuel Gómez,2 Julio Herrero,3 Laura Marque,3 Arturo Brassesco,2 Juan José Espinós3 1Department of Obstetrics and Gynecology, Parc de Salut Mar, Universitat Autònoma de Barcelona, 2Centro de Infertilidad y Reproducción Humana (CIRH, 3Centro de Reproducción Asistida Sagrada Familia, Clínica Sagrada Familia, Barcelona, Spain Abstract: The aim of this study is to evaluate the feasibility and safety of random-start controlled ovarian hyperstimulation (COH for emergency fertility preservation, regardless of the phase of the menstrual cycle. A self-controlled pilot clinical trial (NCT01385332 was performed in an acute-care teaching hospital and in two private reproductive centers in Barcelona, Spain. Eleven egg donors participated in the study. Two random-start gonadotropin-releasing hormone (GnRH antagonist protocols were assessed in which ganirelix was initiated on either day 10 (protocol B or on day 20 (protocol C of the menstrual cycle and was continued until estradiol levels were below 60 pg/dL. These protocols were compared with a standard protocol (protocol A. The main outcome of interest was the number of metaphase 2 oocytes retrieved. Results from this study show that the number of mature oocytes retrieved was comparable across the different protocols (14.3±4.6 in the standard protocol versus 13.0±9.1 and 13.2±5.2 in protocols B and C, respectively; values expressed as mean ± standard deviation. The mean number of days needed for a GnRH antagonist to lower estradiol levels, as well as the ongoing pregnancy rates, were also similar when protocols B (stimulation in follicular phase and C (stimulation on luteal phase were compared with protocol A (standard stimulation. GnRH antagonists can be effectively used for random-start controlled ovarian hyperstimulation with an ovarian response similar to that of standard protocols, and the antagonists appear suitable for emergency

  3. The role of GABA in the regulation of GnRH neurons

    Directory of Open Access Journals (Sweden)

    Miho eWatanabe

    2014-11-01

    Full Text Available Gonadotropin-releasing hormone (GnRH neurons form the final common pathway for the central regulation of reproduction. Gamma-amino butyric acid (GABA has long been implicated as one of the major players in the regulation of GnRH neurons. Although GABA is typically an inhibitory neurotransmitter in the mature adult central nervous system, most mature GnRH neurons show the unusual characteristic of being excited by GABA. While many reports have provided much insight into the contribution of GABA to the activity of GnRH neurons, the precise physiological role of the excitatory action of GABA on GnRH neurons remains elusive. This brief review presents the current knowledge of the role of GABA signaling in GnRH neuronal activity. We also discuss the modulation of GABA signaling by neurotransmitters and neuromodulators and the functional consequence of GABAergic inputs to GnRH neurons in both the physiology and pathology of reproduction.

  4. Maintenance simulation: Software issues

    Energy Technology Data Exchange (ETDEWEB)

    Luk, C.H.; Jette, M.A.

    1995-07-01

    The maintenance of a distributed software system in a production environment involves: (1) maintaining software integrity, (2) maintaining and database integrity, (3) adding new features, and (4) adding new systems. These issues will be discussed in general: what they are and how they are handled. This paper will present our experience with a distributed resource management system that accounts for resources consumed, in real-time, on a network of heterogenous computers. The simulated environments to maintain this system will be presented relate to the four maintenance areas.

  5. Training of maintenance personnel

    International Nuclear Information System (INIS)

    Rabouhams, J.

    1986-01-01

    This lecture precises the method and means developed by EDF to ensure the training of maintenance personnel according to their initial educational background and their experience. The following points are treated: General organization of the training for maintenance personnel in PWR and GCR nuclear power stations and in Creys Malville fast breeder reactor; Basic nuclear training and pedagogical aids developed for this purpose; Specific training and training provided by contractors; complementary training taking into account the operation experience and feedback; Improvement of velocity, competence and safety during shut-down operations by adapted training. (orig.)

  6. Inhibition of RM-1 prostate carcinoma and eliciting robust immune responses in the mouse model by using VEGF-M2-GnRH3-hinge-MVP vaccine.

    Science.gov (United States)

    Wang, Yiqin; Alahdal, Murad; Ye, Jia; Jing, Liangliang; Liu, Xiaoxin; Chen, Huan; Jin, Liang; Cao, Rongyue

    2018-01-23

    GnRH and VEGF have been investigated as prostate carcinoma enhancers that support tumor spread and progression. Although both have documented roles in prostate carcinoma and many cancer types, the weak immunogenicity of these peptides has remained a major challenge for use in immunotherapy. Here, we describe a novel strategy to inhibit GnRH and VEGF production and assess the effect on the immune responses against these hormones using the RM-1 prostate cancer model. We designed a novel recombinant fusion protein which combined GnRH and VEGF as a vaccine against this tumor. The newly constructed fusion protein hVEGF121-M2-GnRH3-hinge-MVP contains the human vascular endothelial growth factor (hVEGF121) and three copies of GnRH in sequential linear alignment and T helper epitope MVP as an immunogenic vaccine. The effectiveness of the vaccine in eliciting an immune response and attenuating the prostate tumor growth was evaluated. Results showed that administration of a new vaccine effectively elicited humoral and cellular immune responses. We found that, a novel fusion protein, hVEGF121-M2-GnRH3-hinge-MVP, effectively inhibited growth of RM-1 prostate model and effectively promoted immune response. In conclusion, hVEGF121-M2-GnRH3-hinge-MVP is an effective dual mechanism tumor vaccine that limits RM-1 prostate growth. This vaccine may be a promising strategy for the treatment of hormone refractory prostate malignancies.

  7. Energy barriers for interlayer diffusion in Pt/Pt(111) and Rh/Rh(111) homoepitaxy: small islands

    Czech Academy of Sciences Publication Activity Database

    Máca, František; Kotrla, Miroslav; Trushin, O. S.

    1999-01-01

    Roč. 49, č. 11 (1999), s. 1591-1596 ISSN 0011-4626. [Symposium on Surface Physics /8./. Třešť, 28.06.1999-02.07.1999] R&D Projects: GA MŠk OC P3.80 Institutional research plan: CEZ:AV0Z1010914 Keywords : molecular statics * energy barriers * Pt and Rh Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.328, year: 1999

  8. GnRH-I and GnRH-II-induced calcium signaling and hormone secretion in neonatal rat gonadotrophs

    Czech Academy of Sciences Publication Activity Database

    Balík, Aleš; Jindřichová, Marie; Bhattacharyya, Sharmistha; Zemková, Hana

    2009-01-01

    Roč. 58, č. 5 (2009), s. 709-716 ISSN 0862-8408 R&D Projects: GA ČR(CZ) GA305/07/0681; GA AV ČR(CZ) IAA500110702; GA MŠk(CZ) LC554 Institutional research plan: CEZ:AV0Z50110509 Keywords : gonadotrophs * GnRH-II * melatonin Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 1.430, year: 2009

  9. Iodine excretion during stimulation with rhTSH in differentiated thyroid carcinoma

    International Nuclear Information System (INIS)

    Loeffler, M.; Weckesser, M.; Franzius, C.; Kies, P.; Schober, O.

    2003-01-01

    Aim: Elevated iodine intake is a serious problem in the diagnostic and therapeutic application of 131 iodine in patients with differentiated thyroid cancer. Therefore, iodine avoidance is necessary 3 months in advance. Additionally, endogenous stimulation requires withdrawal of thyroid hormone substitution for 4 weeks. Exogenous stimulation using recombinant human TSH (rhTSH) enables the continuous substitution of levothyroxine, which contains 65.4% of its molecular weight in iodine. Thus, a substantial source of iodine intake is maintained during exogenous stimulation. Although this amount of stable iodine is comparable to the iodine intake in regions of normal iodine supply, it may reduce the accumulation of radioiodine in thyroid carcinoma tissue. The aim of this study was to assess the iodine excretion depending on different ways of stimulation. Methods: Iodine excretion was measured in 146 patients in the long term follow up after differentiated thyroid carcinoma. Patients were separated into 2 groups, those on hormone withdrawal (G I) and rhTSH-stimulated patients on hormone substitution (G II). Results: Iodine excretion was significantly lower in hypothyroid patients (G I, median 50 μg/l, range: 25-600 μg/l) than in those under levothyroxine medication (G II, median 75 μg/l, 25-600 μg/l, p [de

  10. Management of maintenance activities at Cernavoda NPP

    International Nuclear Information System (INIS)

    Riedel, M.; Urjan, R.; Marinescu, S.; Corlan, L.

    2000-01-01

    After the Construction and Commissioning phases are over, the safety and economic performances of each nuclear unit are determined by the quality of its operation as well as by the combination of reliability and availability of the systems consisting the whole unit. Therefore, the value of a good maintenance program in making a safe and profitable operation is now widely recognized; all stations operating with excellent performance have well-defined policies and effectively administered programs to govern maintenance activities. The Cernavoda maintenance optimization initiative is derived from good practices suggested by such recognized bodies as the IAEA, INPO and EPRI. It should be noted that the program is evolving at this time and that this paper is an attempt to summarize the myriad of activities and plans required to finally implement the maintenance program. Although many of the elements of the program are in place, many are in various stages of completion. The main components of the program (policy's objectives, strategies used, specific subprograms, maintenance plans and their integration) are presented in brief along with the performance indicators used to assess the effectiveness of the program and maintenance activities. The new programs intended to be developed are also specified, as well as the main comments and recommendations received from IAEA experts. (author)

  11. Maintenance and environmental qualification

    International Nuclear Information System (INIS)

    Martin, R.S.; Austin, D.G.

    1995-01-01

    The design of today's nuclear generating plants involves many detailed design considerations. This includes comprehensive look at aging effects on plant components over their expected lifetimes. This is important to ensuring that the plant operates safely throughout its life. The effects of aging are required to be documented in detail in today's designs. This documentation provides assurance that safe operating conditions are maintained throughout the station life cycle. This requirement is analogous to the longer standing requirement to ensure pressure boundary integrity. The pressure boundary integrity requirement has existed in the industry since its inception. The subject of plant aging effects and the maintenance of functionality is known as Environmental Qualification (EQ). This paper will attempt to explain the wisdom of EQ and the potential for optimizing maintenance activities (to move from reactive to proactive activities), within the context of the overall maintenance program. It is the author's intent to encourage the active involvement of maintenance professionals in the effective implementation of the ongoing EQ program so that the benefits are maximized

  12. Maintenance Resources Evaluation Technique.

    Science.gov (United States)

    1999-03-01

    variable Z; P-6 BIBLIOGRAPHY Argentine Air Force. Reglamento de Conduction Logistica RAC 9 (Logistics Management Regulation). Estado Mayor General de ...other hand, too many resources are expensive to acquire and maintain and difficult to transport . 1-1 Sizing the means needed to accomplish its...functional areas (maintenance, supply/inventory, transportation , etc), methodologies of operations research (simulation, mathematical programming

  13. Optimizing preventive maintenance

    International Nuclear Information System (INIS)

    DiCola, F.E.

    1988-01-01

    The traditional approach to preventive maintenance (PM) is based on adherence to manufacturers's requirements and recommended frequencies. When equipment fails, either new procedures are established or the frequency is increased. This leads to an increase in the number of PM activities, overloading not only maintenance resources, but support as well. There is no correlation between more PM and an increase in equipment reliability. More PM may actually induce failures. Reliability-centered maintenance, a new concept in utility maintenance, is based on identifying system/subsystem functions, failures, and dominant failure modes to develop or revise PM tasks. The activities described in this paper are based on actual implementation of this concept on an ongoing project to upgrade the PM program at one of the largest electric utilities in the country. Optimum PM activities are those that, when implemented, will minimize factors that c cause equipment to fail. One technique described illustrates how equipment performance, failure modes, and causes can be related to minimize the occurrence of failures. Operating history and service life of a component are key factors in determining the most effective PM activities, provided that the factors are related to failure modes and causes

  14. Floors: Care and Maintenance.

    Science.gov (United States)

    Post Office Dept., Washington, DC.

    Guidelines, methods and policies regarding the care and maintenance of post office building floors are overviewed in this handbook. Procedures outlined are concerned with maintaining a required level of appearance without wasting manpower. Flooring types and characteristics and the particular cleaning requirements of each type are given along with…

  15. Floors: Selection and Maintenance.

    Science.gov (United States)

    Berkeley, Bernard

    Flooring for institutional, commercial, and industrial use is described with regard to its selection, care, and maintenance. The following flooring and subflooring material categories are discussed--(1) resilient floor coverings, (2) carpeting, (3) masonry floors, (4) wood floors, and (5) "formed-in-place floors". The properties, problems,…

  16. Maintenance procedure upgrade programs

    International Nuclear Information System (INIS)

    Campbell, J.J.; Zimmerman, C.M.

    1988-01-01

    This paper describes a systematic approach to upgrading nuclear power plant maintenance procedures. The approach consists of four phases: diagnosis, program planning, program implementation, and program evaluation. Each phase is explained as a series of steps to ensure that all factors in a procedure upgrade program are considered

  17. Maintenance: problem and solution

    CERN Multimedia

    CERN Bulletin

    2012-01-01

    Equipment that is often unique, machines that are as old as the Laboratory, continuous and demanding performance requirements: these are the challenges faced by CERN’s accelerator maintenance teams. There are some twenty such teams, attached to different departments. A new project aims to standardise their procedures to make their work easier, and you can be a part of it.   “For the past year or so, the Accelerator and Technologies Sector and the GS Department have been working together on identifying the needs of the different teams that perform maintenance on CERN’s equipment. We are now ready to provide computer support with detailed specifics about the processes that need to be set up,” explains Goran Perinić, one of the leaders in CERN’s new Maintenance Management project (MMP). Since the LHC entered operation, the responsibilities of the technical teams have been broadened to cover maintenance of the collider and that of its injectors...

  18. Subcontracting Railway Maintenance

    DEFF Research Database (Denmark)

    Thommesen, Jacob

    2010-01-01

    railway infrastructure manager (InfraMan), whichis subcontracting maintenance tasks to other companies. InfraMan has implemented various central elements in managing their subcontractors. The latter are required to present a safety plan as part of their bid, they must be approved if they are to be awarded...

  19. Operations and maintenance philosophy

    International Nuclear Information System (INIS)

    DUNCAN, G.P.

    1999-01-01

    This Operations and Maintenance (O and M) Philosophy document is intended to establish a future O and M vision, with an increased focus on minimizing worker exposure, ensuring uninterrupted retrieval operations, and minimizing operation life-cycle cost. It is intended that this document would incorporate O and M lessons learned into on-going and future project upgrades

  20. Aircraft Maintenance Expert Systems.

    Science.gov (United States)

    1983-11-01

    PARA 2 -104)) 44: (( JETCAL ANALYSIS SHOWS SYSTEM READS CORRECT) (REPLACE FAULTY PARTS)) 45: ((OVERTEMP EXCEEDED SERVICE LIMITS) 46: I(ENGINE CONTROL...CIRCUITS WITHIN LIMITS ON JETCAL ) (REPLACE FAULTY PARTS)) 47: (ADJUST EST AT AMPLIFIER AND CHECK TENP)) (SEND ENGINE TO HIGHER LEVEL MAINTENANCE)) 48: 2

  1. Telephone Exchange Maintenance

    CERN Multimedia

    2005-01-01

    Urgent maintenance work on CERN telephone exchanges will be performed on 24 March from 6 a.m. to 8 a.m. Telephone services may be disrupted or even interrupted during this time. For more details, please contact us by email at Standard.Telephone@cern.ch.

  2. CH Packaging Maintenance Manual

    International Nuclear Information System (INIS)

    Washington TRU Solutions

    2002-01-01

    This procedure provides instructions for performing inner containment vessel (ICV) and outer containment vessel (OCV) maintenance and periodic leakage rate testing on the following packaging seals and corresponding seal surfaces using a nondestructive helium (He) leak test. In addition, this procedure provides instructions for performing ICV and OCV structural pressure tests

  3. Maintenance: Two Views.

    Science.gov (United States)

    Ballard, J. Barry; Burdette, Clarence E.

    1987-01-01

    Presents two viewpoints on the question of using funding from the Vocational Education Act to maintain ongoing vocational programs. Ballard argues that programs have improved qualitatively because of additional program improvement monies, whereas Burdette argues that the ban on using funds for maintenance treats some states unfairly. (CH)

  4. Maintenance and hazardous substances

    NARCIS (Netherlands)

    Kuhl, K.; Terwoert, J.; Cabecas, J.J.M.

    2012-01-01

    Maintenance workers come into close contact with a broad variety of often hazardous chemicals. Depending on the specific type, these chemicals may not only cause diseases like skin sores or cancer, but many of them are highly flammable and explosive. This e-facts focuses on the specific risks

  5. Building Maintenance Syllabus.

    Science.gov (United States)

    Fischer, Joseph; Messier, Joseph

    Building maintenance is a basic two-year trade education course requiring 2 1/2 hours of study on each of 160 teaching days per year. Student abilities should range from those capable of the simplest custodial work to those who may eventually be superintendents of building complexes. The syllabus is organized in sections by traditional skills…

  6. Maintenance and regulations

    International Nuclear Information System (INIS)

    Noel, R.

    1984-01-01

    Description of the main regulations concerning the processes tied with maintenance and in service supervision of the pressure vessels in classical or nuclear power plants or of their accessories (essentially in order to fix the time-table of the hydraulic test procedures and the inspection chronology [fr

  7. Maintenance in sustainable manufacturing

    Directory of Open Access Journals (Sweden)

    Vladimir Stuchly

    2014-09-01

    Full Text Available Background: Sustainable development is about reaching a balance between economic, social, and environmental goals, as well as people's participation in the planning process in order to gain their input and support. For a company, sustainable development means adoption of such business strategy and actions that contribute to satisfying present needs of company and stakeholders, as well as simultaneous protection, maintenance and strengthening of human and environmental potential which will be needed in the future. This new approach forces manufacturing companies to change their previous management paradigms. New management paradigm should include new issues and develop innovative methods, practices and technologies striving for solving problem of shortages of resources, softening environment overload and enabling development of environment-friendly lifecycle of products. Hence, its realization requires updating existing production models as they are based on previously accepted paradigm of unlimited resources and unlimited regeneration capabilities. Maintenance plays a crucial role because of its impact on availability, reliability, quality and life cycle cost, thus it should be one of the main pillars of new business running model.  Material and methods: The following paper is a result of research on the literature and observation of practices undertaken by a company within maintenance area. Results and conclusions: The main message is that considering sustainable manufacturing requires considerable expanding range of analysis and focusing on supporting processes. Maintenance offers numerous opportunities of decreasing influence of business processes on natural environment and more efficient resources utilization. The goal of maintenance processes realizing sustainable development strategy is increased profitability of exploitation and optimization of total lifecycle cost without disturbing safety and environmental issues. 

  8. Advances in safety related maintenance

    International Nuclear Information System (INIS)

    2000-03-01

    The maintenance of systems, structures and components in nuclear power plants (NPPs) plays an important role in assuring their safe and reliable operation. Worldwide, NPP maintenance managers are seeking to reduce overall maintenance costs while maintaining or improving the levels of safety and reliability. Thus, the issue of NPP maintenance is one of the most challenging aspects of nuclear power generation. There is a direct relation between safety and maintenance. While maintenance alone (apart from modifications) will not make a plant safer than its original design, deficient maintenance may result in either an increased number of transients and challenges to safety systems or reduced reliability and availability of safety systems. The confidence that NPP structures, systems and components will function as designed is ultimately based on programmes which monitor both their reliability and availability to perform their intended safety function. Because of this, approaches to monitor the effectiveness of maintenance are also necessary. An effective maintenance programme ensures that there is a balance between the improvement in component reliability to be achieved and the loss of component function due to maintenance downtime. This implies that the safety level of an NPP should not be adversely affected by maintenance performed during operation. The nuclear industry widely acknowledges the importance of maintenance in NPP safety and operation and therefore devotes great efforts to develop techniques, methods and tools to aid in maintenance planning, follow-up and optimization, and in assuring the effectiveness of maintenance

  9. Mental distress and personality in women undergoing GnRH agonist versus GnRH antagonist protocols for assisted reproductive technology

    DEFF Research Database (Denmark)

    Stenbæk, D. S.; Toftager, M.; Hjordt, L. V.

    2015-01-01

    STUDY QUESTION: Do mental distress and mood fluctuations in women undergoing GnRH agonist and GnRH antagonist protocols for assisted reproductive technology (ART) differ depending on protocol and the personality trait, neuroticism? SUMMARY ANSWER: ART treatment did not induce elevated levels...... of mental distress in either GnRH antagonist or agonist protocols but neuroticism was positively associated with increased mental distress, independent of protocols. WHAT IS KNOWN ALREADY: ART treatment may increase mental distress by mechanisms linked to sex hormone fluctuations. General psychological...... characteristics, such as personality traits indexing negative emotionality, e.g. neuroticism, are likely to affect mental distress during ART treatment. STUDY DESIGN, SIZE, DURATION: A total of 83 women undergoing their first ART cycle were consecutively randomized 1:1 to GnRH antagonist (n = 42) or GnRH agonist...

  10. The comparision of effect of microdose GnRH-a flare-up, GnRH antagonist/aromatase inhibitor letrozole and GnRH antagonist/clomiphene citrate protocols on IVF outcomes in poor responder patients.

    Science.gov (United States)

    Ozcan Cenksoy, Pinar; Ficicioglu, Cem; Kizilkale, Ozge; Suhha Bostanci, Mehmet; Bakacak, Murat; Yesiladali, Mert; Kaspar, Cigdem

    2014-07-01

    To compare the effects of microdose GnRH-a flare-up, GnRH antagonist/aromatase inhibitor letrozole and GnRH antagonist/clomiphene citrate protocols on IVF outcomes in poor responder patients. Of 225 patients, 83 patients were in microdose flare-up group (Group 1), 70 patients were in GnRH antagonist/letrozole group (Group 2) and 72 patients were in GnRH antagonist/clomiphene citrate group (Group 3). Demographic and endocrine characteristics, the total number of oocytes retrieved, cancellation rate and clinical pregnancy rate were collected Results: Total dosage of gonadotropins (p=0.002) and serum E2 levels on the day of hCG administration (p=0.010) were significantly higher and duration of stimulations (p=0.03) was significantly longer in group 1. The number of oocytes retrieved was significantly greater in group 1 and 2 when compare to those of group 3 (p=0,000). There was a trend towards increasing cycle cancellation rates with GnRH antagonist/clomiphene citrate and GnRH antagonist/letrozole. Our finding suggest that the results of microdose flare-up protocol are better than other two used treatment protocols, in terms of maximum estradiol levels, number of mature oocytes retrieved, and cancellation rate and it still seems to be superior the ovarian stimulation regime for the poor responder patients.

  11. Experimental investigation of air relative humidity (RH) cycling tests on MEA/cell aging in PEMFC. Pt. II. Study of low RH cycling test with air RH at 62%/0%

    Energy Technology Data Exchange (ETDEWEB)

    Huang, B.T.; Chatillon, Y.; Bonnet, C.; Lapicque, F. [Laboratoire Reactions et Genie des Procedes, CNRS-Nancy University, Nancy (France); Leclerc, S. [Laboratoire d' Energetique et de Mecanique Theorique et Appliquee, CNRS-Nancy University, Vandoeuvre-les-Nancy (France); Hinaje, M.; Rael, S. [Groupe de Recherche en Electrotechnique et Electronique de Nancy, Nancy University, Vandoeuvre-les-Nancy (France)

    2012-06-15

    The effect of low relative humidity (RH) cycling (RH{sub C} 62%/0%) on the degradation mechanisms of a single proton exchange membrane fuel cell (5 x 5 cm{sup 2}) was investigated and compared to a cell operated at constant humidification (RH{sub C} = 62%). The overall cell performance loss was near 33 {mu}V h{sup -1}, which is greater than the voltage decay under constant RH condition near 3 {mu}V h{sup -1}. The electroactive surface was reduced but to an acceptable level. Impedance spectroscopy revealed that the ohmic and charge transfer resistances were reduced by the likely improved hydration of the ionomeric layer at the catalyst due to hydrogen crossover. This was so important that H{sub 2} starvation was finally responsible for the collapse of the cell after 650 h. Transmission electron microscopy showed occurrence of various phenomena, e.g., bubbles and pinholes formation in the membrane due to local overheat from hydrogen combustion at the cathode, and thickness reduction of catalytic layers. The water up take obtained by {sup 1}H NMR within the membrane electrode assembly (MEA) after low RH cycling reduced by 24% compared to a fresh MEA. Observations are also compared to those obtained at high RH cycling (RH{sub C} 62%/100%) presented in Part I of this study [1]. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  12. Cost-effectiveness of the management of rh-negative pregnant women.

    Science.gov (United States)

    Duplantie, Julie; Gonzales, Odilon Martinez; Bois, Antoine; Nshimyumukiza, Léon; Gekas, Jean; Bujold, Emmanuel; Morin, Valérie; Vallée, Maud; Giguère, Yves; Gagné, Christian; Rousseau, François; Reinharz, Daniel

    2013-08-01

    The purpose of this study was to determine the most cost-effective option to prevent alloimmunization against the Rh factor. A virtual population of Rh-negative pregnant women in Quebec was built to simulate the cost-effectiveness of preventing alloimmunization. The model considered four options: (1) systematic use of anti-D immunoglobulin; (2) fetal Rh(D) genotyping; (3) immunological determination of the father's Rh type; (4) mixed screening: immunological determination of the father's Rh type, followed if positive by fetal Rh(D) genotyping. Two outcomes were considered, in addition to the estimated costs: (1) the number of babies without hemolytic disease, and (2) the number of surviving infants. In a first pregnancy, two options emerged as the most cost-effective options: systematic prophylaxis and immunological Rh typing of the father, with overlapping confidence intervals between them. In a second pregnancy, the results were similar. In all cases (first or second pregnancy or a combination of the two) fetal genotyping was not found to be a cost-effective option. Routine prophylaxis and immunological Rh typing of the father are the most cost-effective options for the prevention of Rh alloimmunization. Considering that immunological typing of the father would probably not be carried out by the majority of clinicians, routine prophylaxis remains the preferred option. However, this could change if the cost of Rh(D) fetal genotyping fell below $140 per sample.

  13. Characteristics of Mammalian Rh Glycoproteins (SLC42 transporters) and Their Role in Acid-Base Transport

    Science.gov (United States)

    Nakhoul, Nazih L.; Hamm, L. Lee

    2012-01-01

    The mammalian Rh glycoproteins belong to the solute transporter family SLC42 and include RhAG, present in red blood cells, and two non-erythroid members RhBG and RhCG that are expressed in various tissues, including kidney, liver, skin and the GI tract. The Rh proteins in the red blood cell form an “Rh complex” made up of one D-subunit, one CE-subunit and two RhAG subunits. The Rh complex has a well-known antigenic effect but also contributes to the stability of the red cell membrane. RhBG and RhCG are related to the NH4+ transporters of the yeast and bacteria but their exact function is yet to be determined. This review describes the expression and molecular properties of these membrane proteins and their potential role as NH3/NH4+ and CO2 transporters. The likelihood that these proteins transport gases such as CO2 or NH3 is novel and significant. The review also describes the physiological importance of these proteins and their relevance to human disease. PMID:23506896

  14. A conserved non-reproductive GnRH system in chordates.

    Directory of Open Access Journals (Sweden)

    Takehiro G Kusakabe

    Full Text Available Gonadotropin-releasing hormone (GnRH is a neuroendocrine peptide that plays a central role in the vertebrate hypothalamo-pituitary axis. The roles of GnRH in the control of vertebrate reproductive functions have been established, while its non-reproductive function has been suggested but less well understood. Here we show that the tunicate Ciona intestinalis has in its non-reproductive larval stage a prominent GnRH system spanning the entire length of the nervous system. Tunicate GnRH receptors are phylogenetically closest to vertebrate GnRH receptors, yet functional analysis of the receptors revealed that these simple chordates have evolved a unique GnRH system with multiple ligands and receptor heterodimerization enabling complex regulation. One of the gnrh genes is conspicuously expressed in the motor ganglion and nerve cord, which are homologous structures to the hindbrain and spinal cord of vertebrates. Correspondingly, GnRH receptor genes were found to be expressed in the tail muscle and notochord of embryos, both of which are phylotypic axial structures along the nerve cord. Our findings suggest a novel non-reproductive role of GnRH in tunicates. Furthermore, we present evidence that GnRH-producing cells are present in the hindbrain and spinal cord of the medaka, Oryzias latipes, thereby suggesting the deep evolutionary origin of a non-reproductive GnRH system in chordates.

  15. Gene Frequency and Heritability of Rh Blood Group Gene in 44 Human Populations

    Directory of Open Access Journals (Sweden)

    Supriyo CHAKRABORTY

    2010-09-01

    Full Text Available The frequency of RhD and Rhd alleles of Rh blood group gene was estimated in 44 human populations distributed all over the world from the RhD phenotypic data. The average frequency of RhD and Rhd allele over these populations was 0.70 and 0.30, respectively. Higher frequency of RhD allele than the expected estimate (0.50 in all the populations, under Hardy-Weinberg equilibrium condition assuming equal frequency of both alleles in the initial population, indicated inbreeding at RhD/d locus as well as natural selection for RhD allele. Very high heritability estimate (84.04% of Rh allele frequency revealed that this trait was under weak selection pressure and resulted in greater genetic variation in existing populations. It is consistent with Fishers fundamental theorem of natural selection. The results from the present study suggest that inbreeding at RhD/d locus and some other factors (possibly mutation, migration and genetic drift other than natural selection alone played major roles in changing the Rh allele frequency in these populations.

  16. Experimental investigation of air relative humidity (RH) cycling tests on MEA/cell aging in PEMFC. Pt. I. Study of high RH cycling test with air RH at 62%/100%

    Energy Technology Data Exchange (ETDEWEB)

    Huang, B.T.; Chatillon, Y.; Bonnet, C.; Lapicque, F. [Laboratoire Reactions et Genie des Procedes, CNRS-Nancy University, Nancy (France); Leclerc, S. [Laboratoire d' Energetique et de Mecanique Theorique et Appliquee, CNRS-Nancy University, Vandoeuvre-les-Nancy (France); Hinaje, M.; Rael, S. [Groupe de Recherche en Electrotechnique et Electronique de Nancy, CNRS-Nancy University, Vandoeuvre-les-Nancy (France)

    2012-06-15

    The effect of high air relative humidity (RH) cycling (RH{sub C} 62%/100%) on the degradation mechanisms of a single (5 x 5 cm{sup 2}) proton exchange membrane fuel cells was investigated. The cell performance was compared to a cell operated at constant humidification (RH{sub C} = 62%). Runs were conducted over approximately 1,500 h at 0.3 A cm{sup -2}. The overall loss in cell performance for the high RH cycling test was 12 {mu}V h{sup -1} whereas it was at 3 {mu}V h{sup -1} under constant humidification. Impedance spectroscopy reveals that the ohmic and charge transfer resistances were little modified in both runs. H{sub 2} crossover measurement indicated that both high RH cycling and constant RH test did not promote serious effect on gas permeability. The electroactive surface loss for anode and cathode during high air RH cycling was more significant than at constant RH operation. The water uptake determined by {sup 1}H nuclear magnetic resonance within the membrane electrode assembly (MEA) after high RH cycling was reduced by 12% in comparison with a fresh MEA. Transmission electron microscopy showed bubbles and pinholes formation in the membrane, catalyst particles agglomeration (also observed by X-ray diffraction), catalyst particles migration in the membrane and thickness reduction of the catalytic layers. Scanning electron microscopy was conducted to observe the changes in morphology of gas diffusion layers after the runs. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  17. Gallium-containing Heusler phases ScRh{sub 2}Ga, ScPd{sub 2}Ga, TmRh{sub 2}Ga and LuRh{sub 2}Ga. Magnetic and solid state NMR-spectroscopic characterization

    Energy Technology Data Exchange (ETDEWEB)

    Heletta, Lukas; Seidel, Stefan; Poettgen, Rainer [Muenster Univ. (Germany). Inst. fuer Anorganische und Analytische Chemie; Benndorf, Christopher [Leipzig Univ. (Germany). Inst. fuer Mineralogie, Kristallographie und Materialwissenschaften; Eckert, Hellmut [Muenster Univ. (Germany). Inst. fuer Physikalische Chemie; Sao Paulo Univ., Sao Carlos (Brazil). Inst. of Physics

    2017-10-01

    The gallium-containing Heusler phases ScRh{sub 2}Ga, ScPd{sub 2}Ga, TmRh{sub 2}Ga and LuRh{sub 2}Ga have been synthesized by arc-melting of the elements followed by different annealing sequences to improve phase purity. The samples have been studied by powder X-ray diffraction. The structures of Lu{sub 0.97}Rh{sub 2}Ga{sub 1.03} (Fm3m, a=632.94(5) pm, wR2=0.0590, 46 F{sup 2} values, seven variables) and Sc{sub 0.88}Rh{sub 2}Ga{sub 1.12} (a=618.91(4) pm, wR2=0.0284, 44 F{sup 2} values, six variables) have been refined from single crystal X-ray diffractometer data. Both gallides show structural disorder through Lu/Ga and Sc/Ga mixing. Temperature dependent magnetic susceptibility measurements showed Pauli paramagnetism for ScRh{sub 2}Ga, ScPd{sub 2}Ga, and LuRh{sub 2}Ga and Curie-Weiss paramagnetism for TmRh{sub 2}Ga. {sup 45}Sc and {sup 71}Ga solid state MAS NMR spectroscopic investigations of the Sc containing compounds confirmed the site mixing effects typically observed for Heusler phases. The data indicate that the effect of mixed Sc/Ga occupancy is significantly stronger in ScRh{sub 2}Ga than in ScPd{sub 2}Ga.

  18. Standard enthalpies of formation of selected Rh2YZ Heusler compounds

    International Nuclear Information System (INIS)

    Yin, Ming; Nash, Philip

    2015-01-01

    The standard enthalpies of formation (Δ f H°) of selected ternary Rh-based Rh 2 YZ (Y = Cu, Fe, Mn, Ni, Ru, Ti, V; Z = Al, Ga, In, Si, Ge, Sn) compounds were measured using high temperature direct reaction calorimetry. The measured standard enthalpies of formation (in kJ/mol of atoms) are, for the Heusler compound Rh 2 MnSn (−40.1 ± 3.6), for the B2-structured compounds: Rh 2 FeAl (−48.5 ± 2.9); Rh 2 MnAl (−72.4 ± 2.7); Rh 2 MnGa (−55.3 ± 2.0); Rh 2 MnIn (−35.3 ± 1.9), for the tetragonal compounds: Rh 2 FeSn (−28.9 ± 1.3); Rh 2 TiAl (−97.6 ± 2.2); Rh 2 TiGa (−79.0 ± 1.8); Rh 2 TiSn (−74.7 ± 3.1). Values are compared with those from first principles calculations in published papers and the Open Quantum Materials Database (OQMD). Lattice parameters of these compounds are determined using X-ray diffraction analysis (XRD). Microstructures were characterized using scanning electron microscopy (SEM) and Energy Dispersive Spectroscopy (EDS). - Highlights: • Standard enthalpies of formation of Rh 2 YZ were measured using a drop calorimeter. • Measured enthalpies agree with first principles data in general. • Lattice parameters and related phase relationships were consistent with literature data. • Rh 2 TiSn of tI8 structure were reported for the first time.

  19. Standard enthalpies of formation of selected Rh{sub 2}YZ Heusler compounds

    Energy Technology Data Exchange (ETDEWEB)

    Yin, Ming, E-mail: myin1@hawk.iit.edu; Nash, Philip

    2015-11-25

    The standard enthalpies of formation (Δ{sub f}H°) of selected ternary Rh-based Rh{sub 2}YZ (Y = Cu, Fe, Mn, Ni, Ru, Ti, V; Z = Al, Ga, In, Si, Ge, Sn) compounds were measured using high temperature direct reaction calorimetry. The measured standard enthalpies of formation (in kJ/mol of atoms) are, for the Heusler compound Rh{sub 2}MnSn (−40.1 ± 3.6), for the B2-structured compounds: Rh{sub 2}FeAl (−48.5 ± 2.9); Rh{sub 2}MnAl (−72.4 ± 2.7); Rh{sub 2}MnGa (−55.3 ± 2.0); Rh{sub 2}MnIn (−35.3 ± 1.9), for the tetragonal compounds: Rh{sub 2}FeSn (−28.9 ± 1.3); Rh{sub 2}TiAl (−97.6 ± 2.2); Rh{sub 2}TiGa (−79.0 ± 1.8); Rh{sub 2}TiSn (−74.7 ± 3.1). Values are compared with those from first principles calculations in published papers and the Open Quantum Materials Database (OQMD). Lattice parameters of these compounds are determined using X-ray diffraction analysis (XRD). Microstructures were characterized using scanning electron microscopy (SEM) and Energy Dispersive Spectroscopy (EDS). - Highlights: • Standard enthalpies of formation of Rh{sub 2}YZ were measured using a drop calorimeter. • Measured enthalpies agree with first principles data in general. • Lattice parameters and related phase relationships were consistent with literature data. • Rh{sub 2}TiSn of tI8 structure were reported for the first time.

  20. Concepts for measuring maintenance performance and methods for analysing competing failure modes

    International Nuclear Information System (INIS)

    Cooke, Roger; Paulsen, Jette

    1997-01-01

    Measurement of maintenance performance is done on the basis of component history data in which service sojourns are distinguished according to whether they terminate in corrective or preventive maintenance. From the viewpoint of data analysis, corrective and preventive maintenance constitute competing failure nudes. This article examines ways to assess maintenance performance without introducing statistical assumptions, then introduces a plausible statistical model for describing the interaction of preventive and corrective maintenance, and finally illustrates these with examples from the Nordic TUD data system

  1. Perencanaan Kegiatan Maintenance Dengan Metode Reability Centered Maintenance (Rcm) II

    OpenAIRE

    Rachmad Hidayat; Nachnul Ansori; Ali Imron

    2010-01-01

    Maintenance Activity Planning by Reability Centered Maintenance (RCM) II Method. This research discussmaintenance activity by using RCM II method to determine failure function risk at compresor screw. Calculation isgiven to magnitude optimum time maintenance interval by considering the cost maintenance and the cost reparation.From the research results with RPN points out that critical component that needs to get main priority in givemaintenance on compresor screw are bust logistic on timeworn...

  2. Magnetic anomaly in superconducting TmRh4B4

    International Nuclear Information System (INIS)

    Smith, J.L.; Huang, C.Y.; Tsou, J.J.; Ho, J.C.

    1978-01-01

    The magnetic and superconducting properties of TmRh 4 B 4 (which becomes superconducting at 9.6 K) by means of ac and dc magnetic susceptibility and specific heat measurements are investigated. At 10.7 K, an ac susceptibility peak similar to those found in spin glasses has been observed. In addition, a pronounced specific heat peak has been observed at 11.4 K. The susceptibility peak is essentially unaffected by substitution of 1% Lu or Er for the Tm, but it diminishes when much larger amounts of Er are substituted. The physical origin of this anomalous peak will be discussed

  3. Davis PV plant operation and maintenance manual

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-09-01

    This operation and maintenance manual contains the information necessary to run the Photovoltaics for Utility Scale Applications (PVUSA) test facility in Davis, California. References to more specific information available in drawings, data sheets, files, or vendor manuals are included. The PVUSA is a national cooperative research and demonstration program formed in 1987 to assess the potential of utility scale photovoltaic systems.

  4. Interval of Routine Maintenance and Maintenance Performance: A Literature Review

    Directory of Open Access Journals (Sweden)

    Au-Yong Cheong Peng

    2016-01-01

    Full Text Available In high-rise residential buildings, the quality of facilities management services is significant to the normal operation of the facilities. Unfortunately, lack of concern towards building maintenance, especially preventive maintenance, happens in domestic housing industry in Malaysia. Majority of the maintenance operations of condominiums suffer from lack of planning, lack of proactive maintenance plan, and lack of proper implementation. Thus, this paper reviews the implementation of preventive maintenance strategy, routine maintenance in specific. An extensive review of literature published in 1987 to 2014 is performed for the purpose of this research. The publications are sourced from journal articles, conference proceedings and books. The literature analysis confirms that the routine maintenance of facilities and building services is vital and it can be influential towards the maintenance performance. Subsequently, a theoretical framework is developed, which shows the relationship between routine maintenance of building facilities & services and maintenance performance. The building facilities & services are divided into two categories. They are essential facilities & services that ensure the safety, health, habitability, and operability of buildings; while value-added facilities & services deal with property value, return on investment, and quality living of buildings. Based on the findings, a future research is proposed, which aims to identify the appropriate routine of maintenance for the facilities and services in high-rise residential buildings to improve the maintenance performance.

  5. Blood doses and remnant biokinetics after thyroid ablation therapy of differentiated thyroid cancer: withdrawal vs. rh TSH

    International Nuclear Information System (INIS)

    Lassmann, Michael; Haenscheid, Heribert; Luster, Markus; Reiners, Christoph; Ablation, Trial Study Group

    2005-01-01

    Full text: An international randomized multicenter trial (9 sites; North America: 5, Europe: 4) was carried out investigating the effectiveness of ablation therapy with 3.7 GBq 131 I in differentiated thyroid cancer. We present the results of the trial dosimetry assessments. 63 patients were randomized after thyroidectomy to either hypothyroidism (THW) or euthyroidism in combination with rh TSH (0.9 mg q d x 2, Thyrogen). The biokinetics and residence times (RT) of the remnants were assessed from 3 neck scans starting 48 h after administration. The blood doses (a surrogate for the bone marrow dose) were calculated from activity concentrations in blood samples and 131 I whole body retention measurements between 2 and 168 h after 131 I administration. The overall dosimetry results were calculated centrally (Wuerzberg) in an externally audited standardized data evaluation procedure. The patient ablation rate was 100%. The 48 h 131 I uptake was lower in the remnant tissue of the rh TSH group: 0.5 ± 0.7%; THW group: 0.9 ±1.0% (p=0.1), the effective half life showed smaller values for the THW group (48.0 ± 52.6 h vs. 67.6 ± 48.9 h, p=0.0116). The mean RT in the remnant tissue was shorter in the rh TSH group: 0.9 ± 1.3 h; THW group: 1.4 ± 1.5 h (p=0.1). A greater decrease in the mean percentage of administered activity in the blood at 48 h, and a lower mean residence time was seen in the rh TSH group: 0.8%, RT: 2.3 ± 0.7 h; THW group: 1.8% (p=0.0011), RT: 3.5 ± 1.63 h (p=0.0004). The mean specific blood dose was significantly lower (p<0.0001) in the rh TSH group (0.072 ± 0.017 mGy/MBq, blood vessel radius (VR):0.2 mm; 0.104 ± 0.025 mGy/MBq, VR: 5 mm) than in the Hypothyroid group (0.106 ± 0.037 mGy/MBq, VR: 0.2 mm; 0.158 ± 0.059 mGy/MBq, VR: 5 mm). Conclusion: Although the remnant RT tended to be lower in the rh TSH group the ablation rates in the 2 study arms were comparable. The radiation dose to the blood was significantly lower in the rh TSH group. This

  6. Selection of maintenance tasks

    Energy Technology Data Exchange (ETDEWEB)

    Dean, B; Rombos, P [Wardrop (W.L.) and Associates Ltd., Winnipeg, MB (Canada)

    1995-10-01

    Two methodologies for maintenance task selection, Reliability Centre Maintenance (RCM) and Degradation Mode Analysis (DMA), are compared with regard to application in the nuclear industry and potential for application at CANDU nuclear power plants. RCM is the favoured one of the two methodologies. It is more thorough than DMA, is well supported within the US nuclear industry, and - with experience in application - is gaining cost effectiveness. There is interest in the use of RCM in other nations, including France and Japan, and it is already being implemented at Bruce A NGS and Bruce B NGS in Canada. DMA lags behind RCM in development and currently there is little experience to support claims of major benefits at reduced cost. Significant advantages over RCM need to be demonstrated if DMA is to gain acceptance in the nuclear industry. (author). 41 refs., 7 tabs., 8 figs.

  7. Maintenance - a design perspective

    International Nuclear Information System (INIS)

    Hedges, K.R.

    1992-01-01

    The paper describes how the CANDU-3 has incorporated, at the design stage, maintenance requirements such as component accessibility, standardization, ease of replacement, reduction in the number of components, and simplified component design. AECL is also active in the planned rehabilitation of the four units at Ontario Hydro's Bruce A nuclear generating station. In addition to conceptual design and development, detailed design and analysis, procurement and site assistance, AECL's Sheridan Park Laboratory will provide important development and mockup facilities. An AECL research and development program on reactor maintenance includes the identification and characterization of aging and degrading mechanisms, the tailoring of developed products to plant requirements, and the identification of areas of international cooperation and information exchange. 3 tabs., 1 fig

  8. Selection of maintenance tasks

    International Nuclear Information System (INIS)

    Dean, B.; Rombos, P.

    1995-10-01

    Two methodologies for maintenance task selection, Reliability Centre Maintenance (RCM) and Degradation Mode Analysis (DMA), are compared with regard to application in the nuclear industry and potential for application at CANDU nuclear power plants. RCM is the favoured one of the two methodologies. It is more thorough than DMA, is well supported within the US nuclear industry, and - with experience in application - is gaining cost effectiveness. There is interest in the use of RCM in other nations, including France and Japan, and it is already being implemented at Bruce A NGS and Bruce B NGS in Canada. DMA lags behind RCM in development and currently there is little experience to support claims of major benefits at reduced cost. Significant advantages over RCM need to be demonstrated if DMA is to gain acceptance in the nuclear industry. (author). 41 refs., 7 tabs., 8 figs

  9. Flight Crew Health Maintenance

    Science.gov (United States)

    Gullett, C. C.

    1970-01-01

    The health maintenance program for commercial flight crew personnel includes diet, weight control, and exercise to prevent heart disease development and disability grounding. The very high correlation between hypertension and overweight in cardiovascular diseases significantly influences the prognosis for a coronary prone individual and results in a high rejection rate of active military pilots applying for civilian jobs. In addition to physical fitness the major items stressed in pilot selection are: emotional maturity, glucose tolerance, and family health history.

  10. Predictors of weight maintenance

    NARCIS (Netherlands)

    Pasman, W.J.; Saris, W.H.M.; Westerterp-Plantenga, M.S.

    1999-01-01

    Objective: To obtain predictors of weight maintenance after a weight-loss intervention. Research Methods and Procedures: An overall analysis of data from two-long intervention studies [n = 67 women; age: 37.9±1.0 years; body weight (BW): 87.0±1.2 kg; body mass index: 32.1±0.5 kg·m-2; % body fat:

  11. Maintenance, a global approach

    International Nuclear Information System (INIS)

    Calmejane, P.

    2001-01-01

    Maintenance is an important economic activity, it can represent up to 40% of operating costs in some fabrication units. The opening of energy markets to competition has led main operators to center their activities on their basis business and to sub-contract subsidiary activities. Subcontracting with strong engagements from the sub-contractor about results, time allowed and costs is now currently applied in nuclear industry. (A.C.)

  12. Computerized plant maintenance management

    International Nuclear Information System (INIS)

    Kozusko, A.M.

    1986-01-01

    The evolution of the computer has and continues to have a great impact on industry. We are in an adjustment cycle with the current computer evolution, and will need to adapt to make the changes for the coming decade. Hardware and software are continually being enhanced. Computers are becoming more powerful and will eventually provide an effective man-machine interface. This paper shares experiences encountered during implementations of computerized maintenance systems

  13. Data management in maintenance outsourcing

    International Nuclear Information System (INIS)

    Murthy, D.N.P.; Karim, M.R.; Ahmadi, A.

    2015-01-01

    Most businesses view maintenance as tasks carried out by technicians and the data collected is mostly cost related. There is a growing trend towards outsourcing of maintenance and the data collection issues are not addressed properly in most maintenance service contracts. Effective maintenance management requires proper data management - data collection and analysis for decision-making. This requires a proper framework and when maintenance is outsourced it raises several issues and challenges. The paper develops a framework for data management when maintenance is outsourced and looks at a real case study that highlights the need for proper data management. - Highlights: • Framework for data management in maintenance outsourcing. • Black-box to grey-box approaches for modelling. • Improvements to maintenance decision-making. • Case study to illustrate the approaches and the shortcomings in data collection

  14. An experimental maintenance management system.

    Science.gov (United States)

    1979-01-01

    The purpose of this study was to evaluate Virginia's maintenance management system and to recommend modifications directed at improving it. The study revealed that (1) the current system of allocating maintenance monies is based upon centerline milea...

  15. A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH

    Directory of Open Access Journals (Sweden)

    Reed Michael C

    2004-09-01

    Full Text Available Abstract In a previous study, a model was developed to investigate the release of luteinizing hormone (LH from pituitary cells in response to a short pulse of gonadotropin-releasing hormone (GnRH. The model included: binding of GnRH to its receptor (R, dimerization and internalization of the hormone receptor complex, interaction with a G protein, production of inositol 1,4,5-trisphosphate (IP3, release of calcium from the endoplasmic reticulum (ER, entrance of calcium into the cytosol via voltage gated membrane channels, pumping of calcium out of the cytosol via membrane and ER pumps, and release of LH. The extended model, presented in this paper, also includes the following physiologically important phenomena: desensitization of calcium channels; internalization of the dimerized receptors and recycling of some of the internalized receptors; an increase in Gq concentration near the plasma membrane in response to receptor dimerization; and basal rates of synthesis and degradation of the receptors. With suitable choices of the parameters, good agreement with a variety of experimental data of the LH release pattern in response to pulses of various durations, repetition rates, and concentrations of GnRH were obtained. The mathematical model allows us to assess the effects of internalization and desensitization on the shapes and time courses of LH response curves.

  16. The TFTR maintenance manipulator

    International Nuclear Information System (INIS)

    Kungl, D.; Loesser, D.; Heitzenroeder, P.; Cerdan, G.

    1989-01-01

    TFTR plans to begin D-T experiments in mid 1990. The D-T experimental program will produce approximately one hundred shots, with a neutron generation rate of 10 19 neutrons per shot. This will result in high levels of activation in TFTR, especially in the vacuum vessel. The primary purpose of the Maintenance Manipulator is to provide a means of remotely performing certain defined maintenance and inspection tasks inside the vacuum torus so as to minimize personnel exposure to radiation. The manipulator consists of a six-link folding boom connected to a fixed boom on a movable carriage. The entire manipulator is housed in a vacuum antechamber connected to the vacuum torus, through a port formerly used for a vacuum pumping duct. The configuration extends 180 0 in either direction to provide complete coverage of the torus. The four 3500 l/s turbopumps which were formerly used in the pumping duct will be mounted on the antechamber. The manipulator will utilize two end effectors. The first, called a General Inspection Arm (GIA) provides a movable platform to an inspection camera and an in-vacuum leak detector. The second is a bilateral, force-reflecting pair of slave arms which utilize specially developed tools to perform several maintenance functions. All components except the slave arms are capable of operating in TFTR's vacuum environment and during 150 0 C bakeout of the torus. (orig.)

  17. Reducing maintenance costs

    International Nuclear Information System (INIS)

    Zaiss, W.; Reuschle, K.; Baier, B.

    2002-01-01

    The increasingly more expensive maintenance measures, cuts in the cost budget, and the loss of know-how on the part of vendors all require a change of policy with respect to maintenance concepts of the part of operators. This also applies to the existing valve concepts, the drives included. Under these aspects, the current drive, which is self-actuated and actuated by outside media, for a parallel-plate valve of a nomial width of 700 was reconsidered. The effort served to reduce maintenance costs and, at the same time, simplify the drive concept as well as cut back on the number of in-service inspections. Moreover, the number of active components were to be minimized and installation conditions in the plant were to be improved. When the boundary conditions to be observed with respect to process technology had been laid down, the competent technical department developed a concept of modification of the drive. A major constituent part was the demonstration of the functioning capability of the new drive under accident conditions. It was achieved mainly by an analytical approach. In the resultant drive concept, the same control valves are employed to actuate a driving cylinder by means of self-actuation or by an outside medium as a function of pressure. (orig.) [de

  18. Maintenance in dental implants

    Directory of Open Access Journals (Sweden)

    Giselle Póvoa Gomes

    2008-01-01

    Full Text Available In implants, maintenance is a decisive factor for obtaining success when implant supported overdentures and dentures are used. The present stud presents, a clinical case of a patient, a 70 year-old white man, with a completely edentulous mandibular alveolar ridge, severe bone resorption with presence of basal bone only, and absence of vestibule. Initially, treatment consisted of the placement of a mandibular overdenture, supported on three implants in the anterior inter-foramen region, as the left implant was transfixed in the basal bone of 2 to 3 millimeters. Eleven years later, another two implants were placed in the anterior area and an immediate load was performed up to the first molars, for the placement of an implant supported fixed. Throughout the entire treatment, meticulous maintenance was carried out, with follow-up for fourteen years, interrupted by the patient’s death. From the third month after the opening the three implants initially placed, the presence of keratinized mucosa, definition of the vestibule, maturation of the alveolar ridge and bone formation in the mento region were observed. It was concluded that good planning, allied to mastery of the technique and adequate maintenance were the prerequisites necessary for obtaining favorable results, success of the present case, and for the patient to have a better quality of life.

  19. Managed maintenance, the next step in power plant maintenance

    International Nuclear Information System (INIS)

    Butterworth, G.; Anderson, T.M.

    1984-01-01

    The Westinghouse Nuclear Services Integration Division managed maintenance services are described. Essential to the management and control of a total plant maintenance programme is the development of a comprehensive maintenance specification. During recent years Westinghouse has jointly developed total plant engineering-based maintenance specifications with a number of utilities. The process employed and the experience to date are described. To efficiently implement the maintenance programme Westinghouse has developed a computer software program specifically designed for day to day use at the power plant by maintenance personnel. This program retains an equipment maintenance history, schedules maintenance activities, issues work orders and performs a number of sophisticated analyses of the maintenance backlog and forecast, equipment failure rates, etc. The functions of this software program are described and details of Westinghouse efforts to support the utilities in reducing outage times through development of predefined outage plans for critical report maintenance activities are given. Also described is the experience gained in the training of specialized maintenance personnel, employing competency-based training techniques and equipment mock-ups, and the benefits experienced, in terms of improved quality and productivity of maintenance performed. The success experienced with these methods has caused Westinghouse to expand the use of these training techniques to the more routine skill areas of power plant maintenance. A significant reduction in the operating costs of nuclear power plants will only be brought about by a significant improvement in the quality of maintenance. Westinghouse intends to effect this change by expanding its international service capabilities and to make major investments in order to promote technological developments in the area of power plant maintenance. (author)

  20. 6. CNS international conference on CANDU maintenance. Proceedings

    International Nuclear Information System (INIS)

    2003-01-01

    The 6th CNS International Conference on CANDU Maintenance took place in Toronto, Ontario on November 16-18, 2003. The theme for the conference was 'Maintenance for Life'. About 270 delegates attended the conference held by the Canadian Nuclear Society. The conference consisted of four parallel sessions, a pattern that continued throughout the conference. Papers were grouped under the following headings: Fuel Channels and End Fittings - Assessments; Fuel Channels and End Fittings - Inspections; Fuel Channels and End Fittings - Maintenance; Fuel Channels and End Fittings - Universal Delivery Machine; Water Upgrading; Performance and Plant Life Improvement; Steam Generator Life Management; Steam Generator Modifications; Steam Generators - Inspections; Steam Generators - Assessments; Maintenance Programs; Feeder Inspections; Feeder Assessment and Mitigation; Valve Maintenance; Instrumentation and Control; Inspection Technology; and Fuel Handling