WorldWideScience

Sample records for rev revised edition

  1. Revising and editing for translators

    CERN Document Server

    Mossop, Brian

    2014-01-01

    Revising and Editing for Translators provides guidance and learning materials for translation students learning to edit texts written by others, and professional translators wishing to improve their self-revision ability or learning to revise the work of others. Editing is understood as making corrections and improvements to texts, with particular attention to tailoring them to the given readership. Revising is this same task applied to draft translations. The linguistic work of editors and revisers is related to the professional situations in which they work. Mossop offers in-depth coverage of a wide range of topics, including copyediting, style editing, structural editing, checking for consistency, revising procedures and principles, and translation quality assessment. This third edition provides extended coverage of computer aids for revisers, and of the different degrees of revision suited to different texts. The inclusion of suggested activities and exercises, numerous real-world examples, a proposed gra...

  2. Revised Safety Instruction 41 (IS41 REV.)

    CERN Multimedia

    SC Secretariat

    2005-01-01

    Please note that the Revised Safety Instruction No. 41 (IS41 REV.), entitled 'The use of plastic and other non-metallic materials at CERN with respect to fire safety and radiation resistance' is available on the web at the following url: https://edms.cern.ch/document/335806/LAST_RELEASED Paper copies can also be obtained from the SC Unit Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  3. Bibliocable. Revised Edition.

    Science.gov (United States)

    Cable Television Information Center, Washington, DC.

    This selective, annotated bibliography is a revision of the original published in 1972 (ED 071 402). Some 104 books, articles, and reports included here deal with access, applications, franchising, regulation, technology, and other aspects of cable television. The listings are of two types in each category. First are revisions of the original…

  4. Medical writing, revising and editing

    DEFF Research Database (Denmark)

    Pilegaard, Morten

    2006-01-01

    The globalization of science makes medical writing, editing and revision a rapidly growing field of linguistic study and practice. Medical science texts are written according to uniform, general guidelines and medical genres have become highly conventionalized in terms of structure and linguistic...... form. Medical editing often takes the form of peer review and mainly addresses issues of contents and overall validity. Medical revision incorporates the checking of the macrostructure and the microstructure of the text, its language and style and its suitability for the target reader or client...

  5. How Adults Learn. Revised Edition.

    Science.gov (United States)

    Kidd, J. R.

    The book's emphasis is on learning during the years of adulthood and examines present-day practice of adult education for practitioners. This revised edition brings up to date advances in such areas of learning as controversial theory; the effects of environment; sensory processes; intellectual capacities; motivation and attitude; transactional…

  6. A Guide to the Elements, Rev. Edition (by Albert Stwertka)

    Science.gov (United States)

    Berger, Reviewed By Daniel

    1999-12-01

    This edition is identical in format and content to the 1996 edition, now sold as the "library edition", except that the names and information for elements 104-109 have been updated. My earlier review still applies; a page-by-page comparison found this edition identical to the first except as noted in the previous sentence. The major revision has been in size and price. The 50% price reduction is welcome, but the format was not changed when the size was reduced, and the resulting 9-point font puts readers at risk of eyestrain. I would like to correct one of the criticisms in my earlier review There is excellent discussion of the industrial uses of each element, as well as its most common source minerals. The more economically important elements are given extensive discussions, detailing industrial uses of the element and its compounds. However, biological activity is given spotty coverage. There is no mention - under "iron" or elsewhere - of the central biological role of iron in oxygen transport or of magnesium in photosynthesis. When coverage appears it is not bad: the roles of calcium in vertebrate and invertebrate skeletons, of fluorine in reducing tooth decay by changing hydroxyapatite to fluorapatite, and of cobalt in vitamin B12 are discussed. While information on transuranium elements has been updated, there has been no attempt to correct several minor errors in spelling, placement, or even information. On page 14 the 1s subshell appears as part of the L (n = 2) shell, and upon the electrolysis of molten sodium chloride on page 54, "sodium collects atthe cathode, and chloride [sic] at...the anode." On page 73 the etymology of "potash" is still given as "potassium-rich ash" rather than "ash burned down in pots", though it is obvious that the latter is intended. On page 74, a picture caption claims that black powder ("potassium nitrate, wood charcoal, and sulfur") is used in modern, high-powered rifle cartridges. In spite of the mistakes, which are relatively

  7. ASSET guidelines. Revised 1991 Edition

    International Nuclear Information System (INIS)

    1991-12-01

    The present publication is an updated version of the IAEA Assessment of Safety Significant Events Team (ASSET) Guidelines, IAEA-TECDOC-573, published in 1990. Sections 5 and 6 include revised definitions and investigation guidelines for identification of both direct and root causes. These revisions were recommended by a Consultants Meeting held in Vienna on 3-7 December 1990. This guidance is not intended to infringe an expert's prerogative to investigate additional items. Its main purpose is to provide a basic structure and ensure consistency in the assessments. Use of the ASSET guidelines should also facilitate comparison between the observations made in different nuclear power plants and harmonize the reporting of generic ASSET results. The guidelines should always be used with a critical attitude and a view to possible improvements

  8. Nuclear Security Recommendations on Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225/Revision 5). Recommendations (Spanish Edition); Recomendaciones de Seguridad Fisica Nuclear sobre la Proteccion Fisica de los Materiales y las Instalaciones Nucleares (INFCIRC/225/Rev.5). Recomendaciones

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-06-15

    This publication, Revision 5 of Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225), is intended to provide guidance to States and their competent authorities on how to develop or enhance, implement and maintain a physical protection regime for nuclear material and nuclear facilities, through the establishment or improvement of their capabilities to implement legislative and regulatory programmes. The recommendations presented in this publication reflect a broad consensus among IAEA Member States on the requirements which should be met for the physical protection of nuclear materials and nuclear facilities.

  9. An Implementation Guide for Intermodal Transportation Career Education. Revised Edition.

    Science.gov (United States)

    Associated Research Corp., South Miami, FL.

    One of a series devoted to career education in transportation, this teachers' guide, which is a revised edition of a guide issued in 1974, covers the planning, implementation, and evaluation of programs in transportation career education and provides forms to be used in these three processes. The most important principles in program planning are…

  10. Probability and Statistics The Science of Uncertainty (Revised Edition)

    CERN Document Server

    Tabak, John

    2011-01-01

    Probability and Statistics, Revised Edition deals with the history of probability, describing the modern concept of randomness and examining "pre-probabilistic" ideas of what most people today would characterize as randomness. This revised book documents some historically important early uses of probability to illustrate some very important probabilistic questions. It goes on to explore statistics and the generations of mathematicians and non-mathematicians who began to address problems in statistical analysis, including the statistical structure of data sets as well as the theory of

  11. Algebra Sets, Symbols, and the Language of Thought (Revised Edition)

    CERN Document Server

    Tabak, John

    2011-01-01

    Algebra, Revised Edition describes the history of both strands of algebraic thought. This updated resource describes some of the earliest progress in algebra as well as some of the mathematicians in Mesopotamia, Egypt, China, and Greece who contributed to this early period. It goes on to explore the many breakthroughs in algebraic techniques as well as how letters were used to represent numbers. New material has been added to the chapter on "modern" algebra, a type of mathematical research that continues to occupy the attention of many mathematicians today.

  12. Geometry The Language of Space and Form (Revised Edition)

    CERN Document Server

    Tabak, John

    2011-01-01

    Geometry, Revised Edition describes geometry in antiquity. Beginning with a brief description of some of the geometry that preceded the geometry of the Greeks, it takes up the story of geometry during the European Renaissance as well as the significant mathematical progress in other areas of the world. It also discusses the analytic geometry of Ren Descartes and Pierre Fermat, the alternative coordinate systems invented by Isaac Newton, and the solid geometry of Leonhard Euler. Also included is an overview of the geometry of one of the most successful mathematicians of the 19th century, Bernha

  13. Second revised edition of JENDL-3 (JENDL-3,2)

    International Nuclear Information System (INIS)

    Kikuchi, Yasuyuki

    1995-01-01

    In Nuclear Data Center, Japan Atomic Energy Research Institute, the development of Japanese standard evaluated nuclear data library, JENDL, since the beginning of 1970s has been advanced. In June, 1994, the second revised edition of the third edition, JENDL-3,2, was opened to public. This JENDL-3,2 is expected to be utilized widely in Japan and abroad by freezing it for the time being as the final version of JENDL. This report is the contents of the publication of JENDL-3,2 of the title 'Present state of Japanese nuclear data activities' made at Physical Society of Japan in 1994. Nuclear data are divided into nuclear reaction data and nuclear structure data. The nuclear reaction data on neutron induction, evaluated nuclear data file and the international cooperation for nuclear data are described. The history of Japanese nuclear data activities, nuclear data libraries in the world and the history of JENDL are introduced. As for the evaluation of JENDL-3, its outline, light, medium and heavy nuclei, the nuclides of nuclear fission products, main actinide nuclides, transuranic elements and gamma ray generation data are reported. As for the bench mark test of JENDL-3,1, its outline, simple system bench mark, fast reactor system, thermal neutron reactor system, shield bench mark and feedback information from bench mark test are described. The evaluation and the bench mark test for LENDL-3,2 are reported. (K.I.)

  14. Safe Handling of Radioisotopes. First Edition with Revised Appendix I

    International Nuclear Information System (INIS)

    1966-01-01

    Under its Statute the International Atomic Energy Agency is empowered to provide for the application of standards of safety for protection against radiation to its own operations and to operations making use of assistance provided by it or with which it is otherwise directly associated. To this end authorities receiving such assistance are required to observe relevant health and safety measures prescribed by the Agency. As a first step, it was considered an urgent task to provide users of radioisotopes with a manual of practice for the safe handling of these substances. The first edition of such a manual was published in 1958 and represented the first of the 'Safety Series', a series of manuals and codes on health and safety published by the Agency. It was prepared after careful consideration of existing national and international codes of radiation safety by a group of international experts and in consultation with other international bodies. This edition presents the first revision. It incorporates in the Appendices the latest recommendations of the International Commission on Radiological Protection and extracts from the report of the Committee II of the I.C.R.P. on permissible dose for internal radiation. The Health Physics and Medical Addenda to this Manual, published as No. 2 and No. 3 in the Safety Series in 1960, give more complete advice to the user on specialized topics.

  15. Delta's Key to the TOEFL iBT[R]: Advanced Skill Practice. Revised Edition

    Science.gov (United States)

    Gallagher, Nancy

    2012-01-01

    Delta's Key to the TOEFL iBT: Advanced Skill Practice is a revised and updated edition of Delta's Key to the Next Generation TOEFL Test. Since the introduction of the TOEFL iBT in 2005, there have been significant changes to some of the test questions, particularly the integrated writing and integrated speaking tasks. The new 2011 edition of…

  16. What Video Games Have to Teach Us about Learning and Literacy. Second Edition: Revised and Updated Edition

    Science.gov (United States)

    Gee, James Paul

    2007-01-01

    The author begins his classic book with "I want to talk about video games--yes, even violent video games--and say some positive things about them." With this simple but explosive statement, one of America's most well-respected educators looks seriously at the good that can come from playing video games. In this revised edition, new games like…

  17. DJ Prinsloo and BP Sathekge (compil- ers — revised edition).

    African Journals Online (AJOL)

    The compilers of this new edition have successfully highlighted the important additions to the last edition of the dictionary. It is important to inform pro- spective users about new information. It is also a marketing strategy to announce the contents of a new product in both the preface and at the back of the cover page, as is the ...

  18. The Self-Concept. Volume 1, A Review of Methodological Considerations and Measuring Instruments. Revised Edition.

    Science.gov (United States)

    Wylie, Ruth C.

    This volume of the revised edition describes and evaluates measurement methods, research designs, and procedures which have been or might appropriately be used in self-concept research. Working from the perspective that self-concept or phenomenal personality theories can be scientifically investigated, methodological flaws and questionable…

  19. Mathematics and the Laws of Nature Developing the Language of Science (Revised Edition)

    CERN Document Server

    Tabak, John

    2011-01-01

    Mathematics and the Laws of Nature, Revised Edition describes the evolution of the idea that nature can be described in the language of mathematics. Colorful chapters explore the earliest attempts to apply deductive methods to the study of the natural world. This revised resource goes on to examine the development of classical conservation laws, including the conservation of momentum, the conservation of mass, and the conservation of energy. Chapters have been updated and revised to reflect recent information, including the mathematical pioneers who introduced new ideas about what it meant to

  20. Formal Dismissal Procedures Under Illinois Teacher Tenure Laws. Revised Edition.

    Science.gov (United States)

    Jenkins, Newell N.; And Others

    This handbook, an updated and revised version of the 1975 original, contains the new statutory requirements, state board of education rules, and court decisions pertaining to teacher dismissal in Illinois. This handbook is designed to acquaint Illinois school administrators and school board members with the legal procedures necessary in dismissal…

  1. Lifelong Adaptability: A Cultural Literacy Perspective (Revised Edition)

    Science.gov (United States)

    Moyer, John Thayer

    2011-01-01

    This revised 1997 ex post facto study attempted to identify a lifelong adaptability curriculum from a cultural literacy perspective. It investigated students' lifelong adaptability ratings of 15 general school subjects as predicted by family structure, parental age, parental educational level, student cultural literacy, and student gender;…

  2. The principles of radio engineering and antennas. II Antennas (2nd revised and enlarged edition)

    Science.gov (United States)

    Belotserkovskii, G. B.

    This book represents the second part of a textbook for technical schools. The characteristics and parameters of antennas are considered along with transmission lines, the theory of single dipoles and radiator systems, and the technological realization of elements and units of the antenna-feeder system, taking into account filters and multiport networks for microwave communications applications, and ferrite circulators and isolators. The first edition of this textbook was published in 1969. For the current edition, the material in the first edition has been revised, and new material has been introduced. Much attention is given to microwave antennas, including, in particular, arrays with electrical scanning characteristics. Other topics discussed are related to the general principles of antennas, the matching of the impedance of transmission lines, the elements of transmission lines, aperture-type antennas for microwaves, and the functional characteristics of antennas for ultrashort waves.

  3. Advances in food composition tables in Japan-Standard Tables Of Food Composition in Japan - 2015 - (Seventh Revised Edition).

    Science.gov (United States)

    Watanabe, Tomoko; Kawai, Ryoko

    2018-01-01

    The latest version of the Standard Tables of Food Composition in Japan-2015- comprises the main food composition table (Standard Tables of Food Composition in Japan-2015-[Seventh revised Edition)) and three supplementary books. The supplementary books are Standard Tables of Food Composition in Japan - 2015 - (Seventh Revised Edition) - Amino Acids -, Standard Tables of Food Composition in Japan - 2015 - (Seventh Revised Edition) - Fatty Acids - and Standard Tables of Food Composition in Japan - 2015 - (Seventh Revised Edition) - Available Carbohydrates, Polyols and Organic Acids-. We believe understanding these food composition tables can give greater insight into Japan's gastronomic culture and changes in eating habits. We expect them to play important roles as part of the East Asia food composition tables. Copyright © 2017. Published by Elsevier Ltd.

  4. Practice Study Outpatient Psychotherapy - Switzerland (PAP-S) : Study design and feasibility (Revised edition)

    OpenAIRE

    Wyl, Agnes von; Crameri, Aureliano; Koemeda, Margit; Tschuschke, Volker; Schulthess, Peter

    2016-01-01

    Revised edition of Von Wyl, A., Crameri, A., Koemeda, M., Tschuchke, V. & Schulthess, P. (2013). The PAP-S (Practice of Ambulant Psychotherapy-Study), Switzerland: Study Design and Feasibility. Zurich University of Applied Sciences, Zurich. The original article was published in German: von Wyl, A., Crameri, A., Koemeda, M., Tschuschke, V. & Schulthess, P. (2013). Praxisstudie ambulante Psychotherapie Schweiz (PAP-S): Studiendesign und Machbarkeit. Psychotherapie-Wissenschaft, 1, 6-22; op...

  5. Light water reactor fuel analysis code FEMAXI-7. Model and structure [Revised edition

    International Nuclear Information System (INIS)

    Suzuki, Motoe; Udagawa, Yutaka; Amaya, Masaki; Saitou, Hiroaki

    2014-03-01

    A light water reactor fuel analysis code FEMAXI-7 has been developed for the purpose of analyzing the fuel behavior in both normal conditions and anticipated transient conditions. This code is an advanced version which has been produced by incorporating the former version FEMAXI-6 with numerous functional improvements and extensions. In FEMAXI-7, many new models have been added and parameters have been clearly arranged. Also, to facilitate effective maintenance and accessibility of the code, modularization of subroutines and functions have been attained, and quality comment descriptions of variables or physical quantities have been incorporated in the source code. With these advancements, the FEMAXI-7 code has been upgraded to a versatile analytical tool for high burnup fuel behavior analyses. This report is the revised edition of the first one which describes in detail the design, basic theory and structure, models and numerical method, and improvements and extensions. The first edition, JAEA-Data/Code 2010-035, was published in 2010. The first edition was extended by orderly addition and disposition of explanations of models and organized as the revised edition after three years interval. (author)

  6. An analysis of teacher’s preparation in implementing 2013 revision edition curriculum on mathematics specialization learning

    Science.gov (United States)

    Susilo, T.; Suryawan, A.

    2018-05-01

    This study aimed to determine the pedagogical competence of teachers, the readiness of planning and implementation of learning related to the implementation 2013 revised edition curriculum on mathematics specialization learning for senior high schools Wonogiri. Informants in this study there are 6 high school mathematics teachers X and XI class who teach in the school district Wonogiri. Data were collected using questionnaire method, interview, observation and documentation. Qualitative data analysis is done interactively through 4 paths: data collection, data reduction, data display, drawing conclusion. The results showed that high school mathematics teacher class X and XI in school district of Wonogiri City. The results show that most high school mathematics teachers in grade X and XI are ready to implement the 2013 revised edition curriculum and a few have not been able to implement due to internal or external factors. High school math teachers at Wonogiri district who are ready to face the 2013 revised edition curriculum have applied 10 teacher pedagogic competency indicators according to Regulation of the national education ministry Number 16 Year 2007 in learning. The readiness and implementation of mathematics learning is in line with the demands of the 2013 revised edition curriculum. Based on the teachers who are not ready, data on issues that arise in the implementation of the 2013 revised edition curriculum. Especially the problems in learning, namely mismatch of Core Competence (KI) and Basic Competence (KD) in teacher manual, material disregard in student handbook and lack of examples of problems that exist in teacher manual.

  7. Revised and enlarged edition: editorial production as an artistic and a literary genre

    Directory of Open Access Journals (Sweden)

    Sofia Gonçalves

    2016-07-01

    Full Text Available The appropriation of the expression «revised and enlarged edition», from the traditional publishing jargon, is presented in this article as a hypotheses to characterize contemporary publishing practices. It consid- ers the publication, in all its stages, as a writing space and as a process that never resigns creativity and criticism.These practices are «revised» (revisited because they imply the problematization of practice, through an exploratory attitude or critic, leading to processes and discourses prepared for a permanent review. And «en- larged» because they expand the operations of each editorial production phase, they iden- tify alternative formats and models, they blur traditional roles (author/editor/designer/ reader and question editing as a mere me- diation for the creation, circulation, reception or reading processes. In this article, we will identify some of the principles and emerging phenomena that help us understand editorial production as an artistic or a literary genre.

  8. Regulations for the safe transport of radioactive material. 1996 edition (revised)

    International Nuclear Information System (INIS)

    2000-01-01

    Following a comprehensive review by panels of experts convened by the IAEA starting in 1991, a revised version of the IAEA Regulations for the Safe Transport of Radioactive Material (formerly Safety Series No. 6) was approved by the Board of Governors in September 1996. This publication supersedes all editions of the Regulations issued under Safety Series No. 6. By 1969, the Regulations had been adopted by almost all international organizations concerned with transport and used by many Member States for their own regulations. Through the worldwide adoption of the IAEA Regulations for all modes of transport, a very high standard of safety in transport has been achieved. In the revisions since the first edition, attempts have been made to find a balance between the need to take account of technical advances and operational experience, and the desirability of providing a stable framework of regulatory requirements. One of the aims of this approach is to allow packages designed to previous versions of the Regulations to continue to be used for a reasonable period of time. It is recognized that not all regulatory changes can be implemented simultaneously; Member States and international organizations are therefore invited, in adopting this revision, to provide for use of both the 'old' requirements and the 'new' ones during a period of transition that may last for a few years. It is further recommended that adoption of these revised Regulations occur within a period of five years from publication to achieve worldwide harmonization of their application. In implementing the provisions of these Regulations, it may be necessary for Member States to issue complementary national regulations. Except as necessary for solely domestic purposes, such national regulations should not conflict with these Regulations. For convenience, the requirements to be met for the transport of specified types of consignments are included in an abbreviated form as Schedules in this publication

  9. Regulations for the safe transport of radioactive material. 1996 edition (revised)

    International Nuclear Information System (INIS)

    2002-01-01

    Following a comprehensive review by panels of experts convened by the IAEA starting in 1991, a revised version of the IAEA Regulations for the Safe Transport of Radioactive Material (formerly Safety Series No. 6) was approved by the Board of Governors in September 1996. This publication supersedes all editions of the Regulations issued under Safety Series No. 6. By 1969, the Regulations had been adopted by almost all international organizations concerned with transport and used by many Member States for their own regulations. Through the worldwide adoption of the IAEA Regulations for all modes of transport, a very high standard of safety in transport has been achieved. In the revisions since the first edition, attempts have been made to find a balance between the need to take account of technical advances and operational experience, and the desirability of providing a stable framework of regulatory requirements. One of the aims of this approach is to allow packages designed to previous versions of the Regulations to continue to be used for a reasonable period of time. It is recognized that not all regulatory changes can be implemented simultaneously. Member States and international organizations are therefore invited, in adopting this revision, to provide for use of both the 'old' requirements and the 'new' ones during a period of transition that may last for a few years. It is further recommended that adoption of these revised Regulations occur within a period of five years from publication to achieve worldwide harmonization of their application. In implementing the provisions of these Regulations, it may be necessary for Member States to issue complementary national regulations. Except as necessary for solely domestic purposes, such national regulations should not conflict with these Regulations. For convenience, the requirements to be met for the transport of specified types of consignments are included in an abbreviated form as Schedules in this publication

  10. An analysis of international situation concerning nuclear security. Focused on the revision to INFCIRC/225/Rev.5

    International Nuclear Information System (INIS)

    Inamura, Tomoaki; Tanabe, Tomoyuki

    2011-01-01

    Since the September 11 attacks in 2001, counterterrorism measures have become not just domestic issues but critical issues that need international cooperation. Various nuclear security measures are in place as part of international counterterrorism measures. This report looks at the trend of international nuclear security measures to get implications for Japan, focusing on INFCIRC/225/Rev.5, an international guideline for physical protection of nuclear materials and nuclear facilities drawn up by IAEA. The observations of this report are as follows: 1) While legally binding nuclear security measures such as multilateral treaties and United Nations Security Council Resolutions impose minimum requirements on individual countries, the approaches led by IAEA or individual countries or private associations aim at more detailed consideration or information sharing to further improve nuclear security. 2) INFCIRC/225/Rev.5 comprises new concepts such as risk-based physical protection and nuclear security culture, as well as extended range of threats such as insiders or stand-off attacks and broader scope of measures to response. Japan should consider incorporation of INFCIRC/225/Rev.5 to its national laws and regulations putting in mind that it may have heavy influence and that Japan pledged to role leadership about nuclear security to international society. (author)

  11. Education and the American Indian: The Road to Self-Determination since 1928. Third Edition, Revised and Enlarged.

    Science.gov (United States)

    Szasz, Margaret Connell

    First published in 1974, this book was the first full-length study of federal Indian education policy. This revised edition brings the material up to date with the addition of analysis and interpretation of trends and policies that shaped Indian education in the 1980s and 1990s. Chapters are arranged chronologically and cover specific eras such as…

  12. Toxic substances: Federal-provincial control -- rev. revised edition. Current issue review No. 88-11E

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, K

    1994-12-31

    This document provides a background and analysis on federal-provincial control of toxic substances, including their control under the Canadian Constitution, legislation passed by both levels of government, political aspects, federal-provincial cooperation, the Green Plan, and the Auditor General`s report. Parliamentary action taken and a chronology of events are also included.

  13. Regulations for the safe transport of radioactive materials. 1973 revised edition (as amended).

    International Nuclear Information System (INIS)

    1979-01-01

    On the basis of a comprehensive review carried out by a panel of experts, a revised version of the International Atomic Energy Agency's Regulations for the Safe Transport of Radioactive Materials was approved by the Board of Governors in September 1972 and published in April 1973 as Safety Series No.6 - 1973 Revised Edition. Minor amendments, together with a number of changes of detail were promulgated by the Director General in 1975 and 1977. In October 1978, the Standing Advisory Group on the Safe Transport of Radioactive Materials, established by the Director General in 1977, reviewed and recommended a small number of additional amendments. The recommendations of SAGSTRAM were subsequently accepted by the Director General. All these minor amendments and changes of detail are incorporated in the present text of the Regulations. The purpose of these Regulations is to establish standards of safety which provide an acceptable level of control of the radiation hazards to persons, property and the environment that are associated with the transport of radioactive material. They apply to the transport by land, water or air, including transport on own account, of radioactive material other than that which is an integral part of the means of transport. Transport includes any operation incidental to the whole course of carriage, such as loading, unloading and storage in transit. The term includes both normal transport and that under accident conditions

  14. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 304, Revision 1 (FGE.304Rev1): Four carboxamides from Chemical Groups 30

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate four flavouring substances in the Flavouring Group Evaluation 304, Revision 1 (FGE.304Rev1) using the Procedure in Commission Regulation (EC) No 1565...... criteria and identity for the materials of commerce have been provided for all four candidate substances....

  15. Administrative Circulars Rev.

    CERN Multimedia

    2003-01-01

    Administrative Circular N° 19 (Rev. 3) - April 2003 Subsistence indemnity - Other expenses necessarily incurred in the course of duty travelAdministrative Circular N° 25 (Rev. 2) - April 2003 Shift work - Special provisions for the Fire and Rescue Service - These circulars have been revised. Human Resources Division Tel. 74128Copies of these circulars are available in the Divisional Secretariats. In addition, administrative and operational circulars, as well as the lists of those in force, are available for consultation on the Web at: http://humanresources.web.cern.ch/humanresources/internal/admin_services/admincirc/listadmincirc.asp

  16. How To Help Your Child Choose a Career. New and Revised Edition. Today's Youth and Tomorrow's Careers Edition.

    Science.gov (United States)

    Otto, Luther B.

    This edition of a handbook aimed at helping parents help their children make a career choice has been rewritten and updated. New material begins with the introduction, which provides a rationale for involving parents in their sons' and daughters' career decisions. Other new material includes sections on women and work, minorities and work,…

  17. A procedure for safety assessment of components with cracks - Handbook. 3rd revised edition

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, P.; Bergman, M.; Brickstad, B.; Dahlberg, L.; Nilsson, F.; Sattari-Far, I. [SAQ Kontroll AB, Stockholm (Sweden)

    1999-12-01

    given objectives, the handbook contains solutions for the stress intensity factor and the limit load for a number of crack geometries of importance for applications. It also contains rules for defect characterization, recommendations for estimation of residual stresses, material data for nuclear applications and a safety evaluation system. To ensure conservatism, the procedure with the given solutions of the stress intensity factor and the limit load has been validated. Predictions of the procedure were compared with the actual outcome of full scale experiments reported in the literature. The first edition of the handbook was released in 1990 and the second in 1991. This third edition has been extensively revised. A new safety evaluation system has been introduced. The conservatism in the method for assessment of secondary stresses has been reduced. The solutions for the stress intensity factor and the limit load, the recommendations for estimation of residual stresses and the given material data for nuclear applications have been updated. A modern Windows based PC-program SACC has been developed which can perform the assessments described in this handbook including calculation of crack growth due to stress corrosion and fatigue. The program also has an option which enables assessment of cracks according to the 1995 edition of the ASME Boiler and Pressure Vessel Code, Section XI. Appendices A, C and H for assessment of cracks in ferritic pressure vessels, austenitic piping and ferritic piping, respectively.

  18. A procedure for safety assessment of components with cracks - Handbook. 3rd revised edition

    International Nuclear Information System (INIS)

    Andersson, P.; Bergman, M.; Brickstad, B.; Dahlberg, L.; Nilsson, F.; Sattari-Far, I.

    1999-12-01

    , the handbook contains solutions for the stress intensity factor and the limit load for a number of crack geometries of importance for applications. It also contains rules for defect characterization, recommendations for estimation of residual stresses, material data for nuclear applications and a safety evaluation system. To ensure conservatism, the procedure with the given solutions of the stress intensity factor and the limit load has been validated. Predictions of the procedure were compared with the actual outcome of full scale experiments reported in the literature. The first edition of the handbook was released in 1990 and the second in 1991. This third edition has been extensively revised. A new safety evaluation system has been introduced. The conservatism in the method for assessment of secondary stresses has been reduced. The solutions for the stress intensity factor and the limit load, the recommendations for estimation of residual stresses and the given material data for nuclear applications have been updated. A modern Windows based PC-program SACC has been developed which can perform the assessments described in this handbook including calculation of crack growth due to stress corrosion and fatigue. The program also has an option which enables assessment of cracks according to the 1995 edition of the ASME Boiler and Pressure Vessel Code, Section XI. Appendices A, C and H for assessment of cracks in ferritic pressure vessels, austenitic piping and ferritic piping, respectively

  19. Student Practice Evaluation Form-Revised Edition online comment bank: development and reliability analysis.

    Science.gov (United States)

    Rodger, Sylvia; Turpin, Merrill; Copley, Jodie; Coleman, Allison; Chien, Chi-Wen; Caine, Anne-Maree; Brown, Ted

    2014-08-01

    The reliable evaluation of occupational therapy students completing practice education placements along with provision of appropriate feedback is critical for both students and for universities from a quality assurance perspective. This study describes the development of a comment bank for use with an online version of the Student Practice Evaluation Form-Revised Edition (SPEF-R Online) and investigates its reliability. A preliminary bank of 109 individual comments (based on previous students' placement performance) was developed via five stages. These comments reflected all 11 SPEF-R domains. A purpose-designed online survey was used to examine the reliability of the comment bank. A total of 37 practice educators returned surveys, 31 of which were fully completed. Participants were asked to rate each individual comment using the five-point SPEF-R rating scale. One hundred and two of 109 comments demonstrated satisfactory agreement with their respective default ratings that were determined by the development team. At each domain level, the intra-class correlation coefficients (ranging between 0.86 and 0.96) also demonstrated good to excellent inter-rater reliability. There were only seven items that required rewording prior to inclusion in the final SPEF-R Online comment bank. The development of the SPEF-R Online comment bank offers a source of reliable comments (consistent with the SPEF-R rating scale across different domains) and aims to assist practice educators in providing reliable and timely feedback to students in a user-friendly manner. © 2014 Occupational Therapy Australia.

  20. [Preliminary textual research on Zhijintang Sanctum re-revised version of Jinling edition of Ben cao gang mu (Compendium of Materia Medica)].

    Science.gov (United States)

    Zheng, Jinsheng

    2014-03-01

    The Zhijintang Sanctum version of the re-revised edition of Jinling edition of Ben cao gang mu (Compendium of Materia Medica)collected by Zhao Huiyuan of Baihe, Henan Province in 2008 was opted as one of the third batch of the National Directory of Rare Ancient Worksin 2010. On the second cover page (patent page), it is recorded as"Original Jiangxi version". However, it is investigated to find that most of its paper sheets were reprinted after the original Jinling version, only scores of paper sheets were supplemented block-printed, including the additional block-printed second preface and Li Jianyuan's submitted report of the Jiangxi version, the re-revised time of which should be after the Jiangxi edition, or 1603. The exact time can be determined only by checking it carefully against another Jinling re-revised version (the Sheyuantang Sanctum edition).

  1. 78 FR 65884 - 2014 Edition Electronic Health Record Certification Criteria: Revision to the Definition of...

    Science.gov (United States)

    2013-11-04

    .../HCPCS as clinical terminologies are best for most other medical settings, those standards sparingly... Administration Common Procedure Coding System (HCPCS) and Current Procedural Terminology, Fourth Edition (CPT-4... in either the Current Dental Terminology (CDT) (the standard specified at Sec. 170.207(b)(3)) or...

  2. Comparison of the Reading Subtests of the Wechsler Individual Achievement Test-Third Edition and the Peabody Individual Achievement Test-Revised/Normative Update

    Science.gov (United States)

    Ott, Lauren M.

    2010-01-01

    This study compared the reading subtests of the Wechsler Individual Achievement Test-Third Edition and the Peabody Individual Achievement Test-Revised/Normative Update. Scores were compared on these two tests in a group of 28 students ages 7 through 12 who were referred or reevaluated for suspected learning problems. The data were collected…

  3. CERN Library | Ted Wilson presents "Engines of discovery: a century of particle accelerators" (revised and expanded edition) | 22 July

    CERN Multimedia

    2014-01-01

    Particle accelerators exploit the cutting edge of every aspect of today's technology and have themselves contributed to many of these technologies. The largest accelerators have been constructed as research tools for nuclear and high energy physics and there is no doubt that it is this field that has sustained their development culminating in the Large Hadron Collider.   Engines of discovery: a century of particle accelerators (revised and expanded edition), by Andrew Sessler and Ted Wilson, World Scientific, 2014, ISBN 9789814417198. An earlier book by the same authors, Engines of Discovery: A Century of Particle Accelerators, chronicled the development of these large accelerators and colliders, emphasising the critical discoveries in applied physics and engineering that drove the field. Particular attention was given to the key individuals who contributed, the methods they used to arrive at their particular discoveries and inventions, often recalling how their human strengths and attit...

  4. 78 FR 11907 - Notice of Forthcoming Workshop To Discuss Revisions to NUREG/BR-0204, Rev. 2 “Instructions for...

    Science.gov (United States)

    2013-02-20

    ... radioactive waste disposal facilities if over-estimated. Additionally, the NRC staff received comments from... Performance Assessment Methodology for Low-Level Radioactive Waste Disposal Facilities'' (ADAMS Accession No..., Rev. 2 ``Instructions for Completing NRC's Uniform Low-Level Radioactive Waste Manifest.'' Information...

  5. Revising the ACS Guidelines for Chemistry Programs in Two-Year Colleges: Shaping the Next Edition

    Science.gov (United States)

    Clevenger, John V.; Wesemann, Jodi L.

    2008-06-01

    Much has changed since the second edition of the ACS Guidelines for Chemistry Programs in Two-Year Colleges was prepared in 1997. The roles that two-year college programs can and do play in providing access to and success in higher education are receiving more attention. Increased knowledge on how people learn, advances in technology, and demands for accountability are changing the educational landscape.

  6. A Selected List of Urban, Environmental and Social Problem Gaming/Simulations. Revised Edition.

    Science.gov (United States)

    Steinwachs, Barbara

    This revised list includes games/simulations for all age levels, though often most applicable at the secondary through adult levels. In her reviews of available products, the author limited her listings to those games/simulations which are useful for educational purposes and which focus directly on social concerns relative to urban and…

  7. Cross-Talk in Comp Theory: A Reader. Second Edition, Revised and Updated.

    Science.gov (United States)

    Villanueva, Victor, Ed.

    This revised and updated resource contains a total of 43 essays that serve to initiate graduate students and more experienced teachers into the theories that inform composition studies. Under Section One--The Givens in Our Conversations: The Writing Process--are these essays: "Teach Writing as a Process Not Product" (Donald M. Murray);…

  8. Cutting through the Hype: The Essential Guide to School Reform. Revised, Expanded, and Updated Edition

    Science.gov (United States)

    David, Jane L.; Cuban, Larry

    2010-01-01

    "Cutting Through the Hype: The Essential Guide to School Reform" is a revised, expanded, and updated version of the classic work by Jane L. David and Larry Cuban. It offers balanced analyses of 23 currently popular school reform strategies, from teacher performance pay and putting mayors in charge to turnaround schools and data-driven instruction.…

  9. Chesneys' radiographic imaging: revised and edited by John Ball and Tony Price. 5. ed.

    International Nuclear Information System (INIS)

    Chesney, D.N.

    1989-01-01

    This book (5th edition) reflects the change in emphasis in radiology from photographic processes towards electronic imaging methods. There is new material on image intensifiers and television imaging, digital imaging and digital subtractions. Analyses of the characteristics of, and defects in, images on radiographs, xeroradiographs and the television on screen are included. Methods, equipment and materials used to record the cathode ray tube image are described and there is new material on the principles of alternative diagnostic imaging techniques such as ultrasound, computed tomography and radionuclide imaging which provide cathode ray tube images. The book is primarily for student radiographers and radiographers studying for postdiplomate qualifications. (author)

  10. Regulations for the Safe Transport of Radioactive Materials. 1964 Revised Edition

    International Nuclear Information System (INIS)

    1965-01-01

    In 1961 the International Atomic Energy Agency, within the framework of its statutory functions and in accordance with recommendations made by its Preparatory Commission and by the Economic and Social Council of the United Nations, published safety regulations which could be applied to the national and international transport of radio active materials by all means of transport. At the same time, the Director General of the Agency indicated that these regulations would be revised at appropriate intervals in consultation with Member States and the organizations concerned and invited suggestions for their improvement in the light of experience and increased knowledge. In preparing the revised regulations presented in this document, the Agency has received considerable support from its Member States and the organizations concerned, which have made extensive studies and suggestions in order to assist in its work. The Agency also convened several meetings of experts from its Member States and of representatives of a number of international organizations, and has been represented in several meetings convened by those organizations. In publishing the revised transport regulations which result from that co-ordinated effort, the Agency aims at proposing a lasting framework of principles and rules, complemented by appropriate technical data, acceptable for the safe transport of radio active materials by air, land and water. In particular, the developments which have been introduced concerning the packaging requirements, the nuclear safety criteria for the transport of fissile materials and the methods for testing packages should facilitate the international acceptance of packages by the authorities concerned. The Board of Governors of the Agency approved the revised regulations in June and September 1964. It authorized the Director General to apply them, as appropriate, to Agency operations and Agency assisted operations and to recommend to Member States and to the

  11. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 21, Revision 4 (FGE.21Rev4)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 59 flavouring substances in the Flavouring Group Evaluation 21, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. This revision...... of these flavouring substances, the specifications for the materials of commerce have also been considered. Adequate specifications including complete purity criteria and identity for the materials of commerce have been provided for all 41 candidate substances...

  12. Environmental impact data for fuels. Part 2: Background information and technical appendix (New revised edition)

    International Nuclear Information System (INIS)

    Uppenberg, S.; Almemark, M.; Brandel, M.; Lindfors, L.G.; Marcus, H.O.; Stripple, H.; Wachtmeister, A.; Zetterberg, L.

    2001-05-01

    This report is a compilation of data concerning environmental impacts from the utilization of different fuels. The entire life cycle is studied, from the extraction of raw materials to combustion. The fuels under study are gasoline, gasoline with MTBE, diesel, fuel oil, LPG, coal, natural gas, peat, refuse, ethanol, RME, DME, methane and wood fuels (forestry residues, Salix, pellets/briquettes). Utilization areas studied are heating plants, cogeneration plants, power plants, domestic boilers, and light and heavy vehicles. In this new edition, the following changes were made: New life cycle analyses have been included, a few new fuels added, electricity from hydroelectric plants, wind power plants and nuclear power plants have been included and some other minor changes

  13. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 24 flavouring substances in the Flavouring Group Evaluation 24, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. This revision...... the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered. Adequate specifications including complete purity criteria and identity for the materials of commerce have been provided for all 24 candidate substances....

  14. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 21, Revision 4 (FGE.21Rev4)

    OpenAIRE

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz; Lund, Pia; Nørby, Karin Kristiane

    2013-01-01

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 59 flavouring substances in the Flavouring Group Evaluation 21, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. This revision is made due to the inclusion of the assessment of new toxicity data on one supporting substance 5,6-dihydro-2,4,6-tris(2-methylpropyl)-4H-1,3,5-dithiazine [FL-no: 15.113], which is considered to be str...

  15. EFSA ; Scientific Opinion on Flavouring Group Evaluation 66, Revision 1 (FGE.66Rev1): Consideration of Furfuryl Alcohol and Related Flavouring Substances Evaluated by JECFA (55th meeting)

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 14 flavouring substances in the Revision 1 of Flavouring Group Evaluation 66, using the Procedure in Commission Regulation (EC) No 1565/2000. None...

  16. Clinical Practice Guidelines for Irritable Bowel Syndrome in Korea, 2017 Revised Edition

    Science.gov (United States)

    Song, Kyung Ho; Jung, Hye-Kyung; Kim, Hyun Jin; Koo, Hoon Sup; Kwon, Yong Hwan; Shin, Hyun Duk; Lim, Hyun Chul; Shin, Jeong Eun; Kim, Sung Eun; Cho, Dae Hyeon; Kim, Jeong Hwan; Kim, Hyun Jung

    2018-01-01

    In 2011, the Korean Society of Neurogastroenterology and Motility (KSNM) published clinical practice guidelines on the management of irritable bowel syndrome (IBS) based on a systematic review of the literature. The KSNM planned to update the clinical practice guidelines to support primary physicians, reduce the socioeconomic burden of IBS, and reflect advances in the pathophysiology and management of IBS. The present revised version of the guidelines is in continuity with the previous version and targets adults diagnosed with, or suspected to have, IBS. A librarian created a literature search query, and a systematic review was conducted to identify candidate guidelines. Feasible documents were verified based on predetermined inclusion and exclusion criteria. The candidate seed guidelines were fully evaluated by the Guidelines Development Committee using the Appraisal of Guidelines for Research and Evaluation II quality assessment tool. After selecting 7 seed guidelines, the committee prepared evidence summaries to generate data exaction tables. These summaries comprised the 4 main themes of this version of the guidelines: colonoscopy; a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols; probiotics; and rifaximin. To adopt the core recommendations of the guidelines, the Delphi technique (ie, a panel of experts on IBS) was used. To enhance dissemination of the clinical practice guidelines, a Korean version will be made available, and a food calendar for patients with IBS is produced. PMID:29605976

  17. Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition

    Science.gov (United States)

    Shin, Jeong Eun; Jung, Hye-Kyung; Lee, Tae Hee; Jo, Yunju; Lee, Hyuk; Song, Kyung Ho; Hong, Sung Noh; Lim, Hyun Chul; Lee, Soon Jin; Chung, Soon Sup; Lee, Joon Seong; Rhee, Poong-Lyul; Lee, Kwang Jae; Choi, Suck Chei; Shin, Ein Soon

    2016-01-01

    The Korean Society of Neurogastroenterology and Motility first published guidelines for chronic constipation in 2005 and was updated in 2011. Although the guidelines were updated using evidence-based process, they lacked multidisciplinary participation and did not include a diagnostic approach for chronic constipation. This article includes guidelines for diagnosis and treatment of chronic constipation to realistically fit the situation in Korea and to be applicable to clinical practice. The guideline development was based upon the adaptation method because research evidence was limited in Korea, and an organized multidisciplinary group carried out systematical literature review and series of evidence-based evaluations. Six guidelines were selected using the Appraisal of Guidelines for Research & Evaluation (AGREE) II process. A total 37 recommendations were adopted, including 4 concerning the definition and risk factors of chronic constipation, 8 regarding diagnoses, and 25 regarding treatments. The guidelines are intended to help primary physicians and general health professionals in clinical practice in Korea, to provide the principles of medical treatment to medical students, residents, and other healthcare professionals, and to help patients for choosing medical services based on the information. These guidelines will be updated and revised periodically to reflect new diagnostic and therapeutic methods. PMID:27226437

  18. Revised

    DEFF Research Database (Denmark)

    Johannsen, Vivian Kvist; Nord-Larsen, Thomas; Riis-Nielsen, Torben

    This report is a revised analysis of the Danish data on CO2 emissions from forest, afforestation and deforestation for the period 1990 - 2008 and a prognosis for the period until 2020. Revision have included measurements from 2009 in the estimations. The report is funded by the Ministry of Climate...

  19. Polymer chemistry (revised edition)

    International Nuclear Information System (INIS)

    Kim, Jae Mum

    1987-02-01

    This book deals with polymer chemistry, which is divided into fourteen chapters. The contents of this book are development of polymer chemistry, conception of polymer, measurement of polymer chemistry, conception of polymer, measurement of polymer, molecule structure of polymer, thermal prosperities of solid polymer, basic theory of polymerization, radical polymerization, ion polymerization, radical polymerization, copolymerization, polymerization by step-reaction, polymer reaction, crown polymer and inorganic polymer on classification and process of creation such as polymeric sulfur and carbon fiber.

  20. New technical knowledge to be implemented to the revision of rules on pipe wall thinning management for PWR Plants. 2006 edition

    International Nuclear Information System (INIS)

    Hirai, Junya; Amano, Yoichi; Nakamura, Takao

    2013-01-01

    Rules for PWR plant pipe wall thinning management were formulated by the Japan Society of Mechanical Engineers in 2006. Since then thinning management of Japanese PWR plants has been carried out based on this rule. Pipe wall thinning phenomena to be dealt with in this rule have been identified in many piping components of power plants. New technical knowledge has been accumulated since the issuance of 2006 edition. We have formulated these knowledge and information about the thinning phenomena in PWR power plants. Given the history of application of this rule, we have to make our best effort to carry out a study of latest technical knowledge and implement them to the revision of rule and improve pipe wall thinning management. This paper summarizes the new technical knowledge and basis to be implemented to the revision of rules on pipe wall thinning management for PWR plants in Japan. (author)

  1. [The Revision and 5th Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5): Consequences for the Diagnostic Work with Children and Adolescents].

    Science.gov (United States)

    Zulauf Logoz, Marina

    2014-01-01

    The Revision and 5th Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5): Consequences for the Diagnostic Work with Children and Adolescents.The present paper describes and discusses the major revisions in DSM-5 for children and adolescents. A major modification is that the separate chapter for disorders first diagnosed in childhood and adolescence was abandoned in favour of the integration of these clinical pictures into the relevant disorder-specific chapters. Several new diagnoses and diagnostic groups were introduced: "Disruptive mood regulation disorder" is a new diagnosis; the different diagnoses for autism were brought together into one, and a new diagnostic group for obsessive-compulsive disorders has been established. The developmental approach of DSM-5 and the integration of dimensional assessment tools are to be welcomed. Practice will show if the critiques afraid of possible increases in prevalences or those who approve the changes will end up being right.

  2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 11, Revision 2 (FGE.11Rev2): Aliphatic dialcohols, diketones, and hydroxyketones from chemical groups 8 and 10

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular......, the Panel was requested to evaluate 12 flavouring substances in the Flavouring Group Evaluation 11, Revision 2 (FGE.11Rev2), using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. These 12 flavouring substances belong to chemical group 10, Annex I of the Commission Regulation (EC...... is a tertiary alcohol) [FL-no: 07.097, 07.165 and 07.184] all belonging to chemical groups 8 and 10. One of the 12 candidate substances possesses four chiral centres [FL-no: 06.134] two possesses two chiral centres [FL-no: 02.133 and 07.168] and four substances possesses one chiral centre [FL-no: 07.097, 07...

  3. Administrative Circular N° 26 (Rev.  5) - November 2004

    CERN Multimedia

    Human Resources Department

    2004-01-01

    Procedure governing the career evolution of staff members The introduction of an electronic individual appraisal report form via EDH for the MAPS exercise entails some modifications to Administrative Circular N° 26 (Rev. 4). The revised version (Rev. 5) is available in departmental secretariats as well as on the Web at the following address: http://cern.ch/hr-web/internal/admin_services/admincirc/listadmincirc.asp Human Resources Department Tel. 74128

  4. Applications of the INFCIRC225/rev5 to the national physical protection regime

    International Nuclear Information System (INIS)

    Kim, Jae Gwang

    2011-01-01

    The IAEA's first effort for playing a key role in physical protection of nuclear material and facilities resulted in the publication of 'Recommendations for the physical protection of nuclear material' in 1972. These recommendations were revised by a group of experts in co-operation with the IAEA Secretariat and the revised version was published in 1975 in INFCIRC/225. The document was subsequently revised in 1977(rev.1), 1989(rev.2), in 1993(rev.3) and 1998(rev4). The Physical Protection regime in ROK has been established on the basis of INFCIRC225 rev4 since 2004 IAEA recently published The INFCIRC 225 rev5 through the 2 years expert consultations. The publication recommended 12 nuclear security fundamentals and requirements of physical protection of nuclear material and nuclear facility to the member states. This paper suggests the several applications to the national physical protection system from the 12 fundamentals and the requirements

  5. The Movement Imagery Questionnaire-Revised, Second Edition (MIQ-RS Is a Reliable and Valid Tool for Evaluating Motor Imagery in Stroke Populations

    Directory of Open Access Journals (Sweden)

    Andrew J. Butler

    2012-01-01

    Full Text Available Mental imagery can improve motor performance in stroke populations when combined with physical therapy. Valid and reliable instruments to evaluate the imagery ability of stroke survivors are needed to maximize the benefits of mental imagery therapy. The purposes of this study were to: examine and compare the test-retest intra-rate reliability of the Movement Imagery Questionnaire-Revised, Second Edition (MIQ-RS in stroke survivors and able-bodied controls, examine internal consistency of the visual and kinesthetic items of the MIQ-RS, determine if the MIQ-RS includes both the visual and kinesthetic dimensions of mental imagery, correlate impairment and motor imagery scores, and investigate the criterion validity of the MIQ-RS in stroke survivors by comparing the results to the KVIQ-10. Test-retest analysis indicated good levels of reliability (ICC range: .83–.99 and internal consistency (Cronbach α: .95–.98 of the visual and kinesthetic subscales in both groups. The two-factor structure of the MIQ-RS was supported by factor analysis, with the visual and kinesthetic components accounting for 88.6% and 83.4% of the total variance in the able-bodied and stroke groups, respectively. The MIQ-RS is a valid and reliable instrument in the stroke population examined and able-bodied populations and therefore useful as an outcome measure for motor imagery ability.

  6. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 21, Revision 5 (FGE.21Rev5): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30

    DEFF Research Database (Denmark)

    Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 41 flavouring substances in Flavouring Group Evaluation 21, Revision 5, using the Procedure in Commission Regulation (EC) No 1565/2000. This revision...... have also been considered. Adequate specifications, including complete purity criteria and identity for the materials of commerce, have been provided for all 41 candidate substances....

  7. Neurosurgery. Fourth edition

    International Nuclear Information System (INIS)

    Simon, L.; Thomas, D.G.T.; Clark, W.K.

    1987-01-01

    The Fourth Edition of this volume in the Operative Surgery Series has been considerably revised to accommodate the many changes which have changed the practice of neurosurgery in the past eight years. There have been advances in technology, such as the wider application of CT scanning, in surgical technique, and in the design of new implantable materials. All these developments have substantially affected both the practice of neurosurgery and the prognosis for the patient and are fully reflected in the new edition

  8. Decimal Classification Editions

    Directory of Open Access Journals (Sweden)

    Zenovia Niculescu

    2009-01-01

    Full Text Available The study approaches the evolution of Dewey Decimal Classification editions from the perspective of updating the terminology, reallocating and expanding the main and auxilary structure of Dewey indexing language. The comparative analysis of DDC editions emphasizes the efficiency of Dewey scheme from the point of view of improving the informational offer, through basic index terms, revised and developed, as well as valuing the auxilary notations.

  9. Decimal Classification Editions

    OpenAIRE

    Zenovia Niculescu

    2009-01-01

    The study approaches the evolution of Dewey Decimal Classification editions from the perspective of updating the terminology, reallocating and expanding the main and auxilary structure of Dewey indexing language. The comparative analysis of DDC editions emphasizes the efficiency of Dewey scheme from the point of view of improving the informational offer, through basic index terms, revised and developed, as well as valuing the auxilary notations.

  10. Validity of Alcohol Use Disorder Identification Test-Korean Revised Version for Screening Alcohol Use Disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Criteria.

    Science.gov (United States)

    Chang, Jung Wei; Kim, Jong Sung; Jung, Jin Gyu; Kim, Sung Soo; Yoon, Seok Joon; Jang, Hak Sun

    2016-11-01

    The Alcohol Use Disorder Identification Test (AUDIT) has been widely used to identify alcohol use disorder (AUD). This study evaluated the validity of the AUDIT-Korean revised version (AUDIT-KR) for screening AUD according to Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria. This research was conducted with 443 subjects who visited the Chungnam National University Hospital for a comprehensive medical examination. All subjects completed the demographic questionnaire and AUDIT-KR without assistance. Subjects were divided into two groups according to DSM-5 criteria: an AUD group, which included patients that fit the criteria for AUD (120 males and 21 females), and a non-AUD group, which included 146 males and 156 females that did not meet AUD criteria. The appropriate cut-off values, sensitivity, specificity, and positive and negative predictive values of the AUDIT-KR were evaluated. The mean±standard deviation AUDIT-KR scores were 10.32±7.48 points in males and 3.23±4.42 points in females. The area under the receiver operating characteristic curve (95% confidence interval, CI) of the AUDIT-KR for identifying AUD was 0.884 (0.840-0.920) in males and 0.962 (0.923-0.985) in females. The optimal cut-off value of the AUDIT-KR was 10 points for males (sensitivity, 81.90%; specificity, 81.33%; positive predictive value, 77.2%; negative predictive value, 85.3%) and 5 points for females (sensitivity, 100.00%; specificity, 88.54%; positive predictive value, 52.6%; negative predictive value, 100.0%). The AUDIT-KR has high reliability and validity for identifying AUD according to DSM-5 criteria.

  11. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2016. Scientific Opinion on Flavouring Group Evaluation 51, Revision 2 (FGE.51Rev2): Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by the JECFA (59th meeting, ) structurally related to alicyclic ketones secondary alcohols and related esters in FGE.09Rev6 (2015b)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    on metabolism and toxicity. The present consideration concerns a group of 24 alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting in 2002 and 63rd meeting in 2004). This revision is made due to inclusion of four additional substances cleared for genotoxicity concern...

  12. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 87, Revision 2 (FGE.87Rev2): Consideration of bicyclic secondary alcohols, ketones and related esters evaluated by JECFA (63rd meeting, ) structurally related to bicyclic secondary alcohols, ketones and related esters evaluated by EFSA in FGE.47Rev1 (2008)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Frandsen, Henrik Lauritz; Nørby, Karin Kristiane

    evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 19 bicyclic secondary alcohols, ketones and related esters evaluated by the JECFA at the 63rd meeting in 2004. This revision of FGE.87 is made due to inclusion of two additional...

  13. Radiotherapy. 2. rev. ed.

    International Nuclear Information System (INIS)

    Wannenmacher, Michael; Debus, Juergen; Wenz, Frederik

    2013-01-01

    The purpose of this medical specialty book, besides presenting the state of the art in clinical radiotherapy and radiooncology, is to explain the basic principles of medical physics and radiobiology. Following a number of chapters on general topics and theory it provides detailed coverage of the individual organ systems, briefly addressing future aspects in the process. The authors relate their view that radiooncology as a medical specialty will continue to be under pressure to change and that it will take continuous innovation to secure its status within the interdisciplinary context around the treatment of cancer patients. The authors of this, the textbook's second edition, have dedicated much space to modern methods and techniques in order to do justice to these developments.

  14. Documentation for the NCES Common Core of Data National Public Education Financial Survey (NPEFS), School Year 2008-09 (Fiscal Year 2009). Revised File Version 1b. NCES 2011-330rev

    Science.gov (United States)

    Cornman, Stephen Q.; Zhou, Lei; Nakamoto, Nanae

    2012-01-01

    This documentation is for the revised file (Version 1b) of the National Center for Education Statistics' (NCES) Common Core of Data (CCD) National Public Education Financial Survey (NPEFS) for school year 2008-2009, fiscal year 2009 (FY 09). It contains a brief description of the data collection along with information required to understand and…

  15. Scientific Opinion on Flavouring Group Evaluation 67 Revision 2 (FGE.67Rev2): Consideration of 28 furan-substituted compounds evaluated by JECFA at the 55th, 65th and 69th meetings (JECFA, 2001, 2006a, 2009b)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    on metabolism and toxicity. The present consideration concerns a group of 28 furan-substituted compounds evaluated by the JECFA. This revision of FGE.67 is due to new data on toxicity for 3-(-methyl-2-furyl) butanal [FL-no: 13.058] providing an appropriate NOAEL for the evaluation of candidate substance [FL...

  16. EFSA CEF Panel (EFSA Panel on Fo od Contact Materials, Enzymes, Flavourings and Proce ssing Aids), 2015. Scientific Opinion on Flavouring Group Evalua tion 35, Revision 1 (FGE.35Rev1)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate three flavouring substances in the Flavouring Group Evaluation 35, Revision 1, using the Procedure in Commission Regulation (EC) No 1565/2000. The present ...

  17. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 82, Revision 1 (FGE.82Rev1): Consideration of Epoxides evaluated by the JECFA (65 th meeting)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of five epoxides evaluated by the JECFA at the 65th meeting in 2005. This revision is made due to inclusion of one additional substance, beta-ionone epoxide [FL-no: 07.170], cleared...

  18. Scientific Opinion on Flavouring Group Evaluation 210 Revision 2 (FGE.210Rev2): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2.4 of FGE.19

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    Safety Authority was requested to evaluate the genotoxic potential of 14 flavouring substances in Flavouring Group Evaluation 210 (FGE.210). In FGE.210, the Panel concluded that the genotoxic potential could not be ruled out for any of the flavouring substances. In FGE.210 Revision1, the Panel co...

  19. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF); Scientific Opinion on Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The European Food Safety Authority (EFSA) asked the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs...... in the Member States. In particular, the Panel was requested to evaluate 19 flavouring substances in the Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2), using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. These 19 flavouring substances belong to chemical groups 15, 16, 22......-no: 03.022] Industry has informed that it occurs as a mixture of E- & Z-isomers, however, the composition of the mixture has to be specified. Two of the flavouring substances are classified into structural class I, seven are classified into structural class II and 10 are classified into structural class...

  20. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 12, Revision 4 (FGE.12Rev4): primary saturated or unsaturated alicyclic alcohols, aldehydes, acids and esters from chemical groups 1 and 7

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 12 flavouring substances in Flavouring Group Evaluation 12, Revision 4 (FGE.12Rev4), including two additional substances, using the Procedure in Commission...... (the Procedure) that integrates information on structure–activity relationships, intake from current uses and the toxicological threshold of concern and available data on metabolism and toxicity. The Panel concluded that none of the 12 substances [FL-nos: 02.134, 02.186, 02.216, 02.217, 05.157, 05.......182, 05.183, 05.198, 08.135, 09.342, 09.670 and 09.829] gives rise to safety concerns at their levels of dietary intake, estimated on the basis of the maximised survey-derived daily intake approach. Besides the safety assessment of these flavouring substances, the specifications for the materials...

  1. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 220, Revision 1 (FGE.220Rev1): alpha,beta-Unsaturated ketones and precursors from chemical subgroup 4.4 of FGE.19: 3(2H)-Furanones

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    in the Member States. In particular, the Panel was asked to evaluate flavouring substances using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. The present revision of FGE.220, FGE.220Rev1, concerns the evaluation of additional data submitted by Industry in response...... was alleviated, since one of the substances, for which positive genotoxicity data in mice were obtained, was not carcinogenic in a valid chronic assay in rats. Therefore, no further genotoxicity tests in somatic cells were required. However, some evidence was also available that this substance might elicit...... was requested. In March 2009 the Flavouring Industry submitted new data in reply to the above requested data for subgroup 4.4b of FGE.220. These data have now been examined by the Panel which has concluded the following. The results of a valid rat fertility and dominant lethal study have shown...

  2. Publishing and Revising Content

    Science.gov (United States)

    Editors and Webmasters can publish content without going through a workflow. Publishing times and dates can be set, and multiple pages can be published in bulk. Making an edit to published content created a revision.

  3. T.J. Kriel (original compiler), D.J. Prinsloo and B.P. Sathekge (compilers revised edition). Popular Northern Sotho Dictionary

    OpenAIRE

    Kwena J. Mashamaite

    2011-01-01

    The compilers of this new edition have successfully highlighted the important additions to the last edition of the dictionary. It is important to inform prospective users about new information. It is also a marketing strategy to announce the contents of a new product in both the preface and at the back of the cover page, as is the case with this dictionary.

  4. Choosing to Participate: Revised Edition

    Science.gov (United States)

    Goldstein, Phyllis; Strom, Adam

    2009-01-01

    "Choosing to Participate" focuses on civic choices--the decisions people make about themselves and others in their community, nation, and world. The choices people make, both large and small, may not seem important at the time, but little by little they shape them as individuals and responsible global citizens. "Choosing to…

  5. Polish Americans. Second, Revised Edition.

    Science.gov (United States)

    Lopata, Helen Znaniecka

    This book examines Polonia, the Polish ethnic community in America created by three giant waves of immigration between 1880 and 1990. The complicated history of this ethnic group is reflected in the lives of increasing numbers of Polish Americans, including recent immigrants brought by political and economic changes, as they achieve middle class…

  6. Automotive Electronics. Teacher Edition (Revised).

    Science.gov (United States)

    Mackert, Howard C.; Heiserman, Russell L.

    This learning module addresses computers and their applications in contemporary automobiles. The text provides students with information on automotive microcomputers and hands-on activities that will help them see how semiconductors and digital logic devices fit into the modern repair facility. The module contains nine instructional units that…

  7. Cryochemistry (2nd revised edition)

    Energy Technology Data Exchange (ETDEWEB)

    Sergeev, G.B.; Batiuk, V.A.

    1986-01-01

    Chemical reactions at low temperatures are characterized, summarizing the results of Soviet research since the late 1950s. Chapters are devoted to homogeneous and heterogeneous low-temperature reactions of gases and liquids, apparatus and techniques for cryochemistry, reactions of ions and radicals in frozen solids, low-temperature polymerization, chain reactions, spontaneous reactions, kinetic models of solid-phase reactions, reactions in multicomponent frozen systems, biochemical reactions at reduced and low temperatures, reactions involving metals, and science and engineering applications of low temperatures. 813 references.

  8. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 11, Revision 3 (FGE.11Rev3): Aliphatic dialcohols, diketones, and hydroxyketones from chemical groups 8 and 10

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Frandsen, Henrik Lauritz; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 11 flavouring substances in the Flavouring Group Evaluation 11, Revision 3, using the Procedure in Commission Regulation (EC) No 1565/2000. The substances......, the specifications for the materials of commerce have also been considered. Specifications including complete purity criteria and identity for the materials of commerce have been provided for all candidate substances....

  9. Administrative Circular No. 26 (Rev. 9) – Recognition of Merit

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 26 (Rev. 9) entitled "Recognition of Merit”, approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 September 2011 is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp The circular was above all revised in order to integrate the new CERN Competency Model into the annual procedure of performance appraisal. It cancels and replaces Administrative Circular No. 26 (Rev. 8) entitled "Recognition of merit” of September 2008. Department Head Office HR Department

  10. Nair handbook. 1995 edition

    International Nuclear Information System (INIS)

    1995-01-01

    This Handbook contains general background, administrative and technical information for those participating in the National Arrangements for Incidents involving Radioactivity (NAIR), updating and replacing the previous edition published in 1987. The overriding need for revision was brought about as a result of changes introduced by British Telecom to the telephone numbers of establishments. (UK)

  11. T.J. Kriel (original compiler, D.J. Prinsloo and B.P. Sathekge (compilers revised edition. Popular Northern Sotho Dictionary

    Directory of Open Access Journals (Sweden)

    Kwena J. Mashamaite

    2011-10-01

    Full Text Available The compilers of this new edition have successfully highlighted the important additions to the last edition of the dictionary. It is important to inform prospective users about new information. It is also a marketing strategy to announce the contents of a new product in both the preface and at the back of the cover page, as is the case with this dictionary.

  12. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 303, Revision 1 (FGE.303Rev1): Spilanthol from chemical group 30

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the flavouring substance spilanthol [FL-no: 16.121] in Flavouring Group Evaluation 303, Revision 1, using the Procedure according to Commission Regulation...... (MSDI) approach. Besides the safety assessment of the flavouring substance, the specifications for the material of commerce have also been considered. Adequate specifications including complete purity criteria and identity for the material of commerce have been provided for the candidate substance....

  13. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 25, Revision 3 (FGE.25Rev3): Aliphatic hydrocarbons from chemical group 31

    DEFF Research Database (Denmark)

    Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 14 flavouring substances in the Flavouring Group Evaluation 25, Revision 3, using the Procedure in Commission Regulation (EC) No 1565/2000. None...... on the basis of the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered. Adequate specifications including complete purity and identity criteria for the materials of commerce have been provided for all 14...

  14. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 61 flavouring substances in the Flavouring Group Evaluation 10, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. None of the sub......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 61 flavouring substances in the Flavouring Group Evaluation 10, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. None...... of the substances were considered to have genotoxic potential. The substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity....... The Panel concluded that the 61 substances do not give rise to safety concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered. For four...

  15. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 37 flavouring substances in the Flavouring Group Evaluation 25, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. None of the sub......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 37 flavouring substances in the Flavouring Group Evaluation 25, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. None...... of the substances were considered to have genotoxic potential. The substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity...... assessment of these flavouring substances, the specifications for the materials of commerce have also been considered. For five substances, the composition of the stereoisomeric mixture has to be specified further....

  16. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 21, Revision 3 (FGE.21Rev3): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 59 flavouring substances in the Flavouring Group Evaluation 21, including an additional three substances in this Revision 3, using the Procedure in Commiss......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 59 flavouring substances in the Flavouring Group Evaluation 21, including an additional three substances in this Revision 3, using the Procedure.......086, 15.090, 15.099, 15.114, 15.119 and 15.133] were considered to have genotoxic potential. The remaining 52 substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern.......092, 15.093, 15.094, 15.096, 15.097, 15.106, 15.107, 15.129 and 15.135] evaluated through the Procedure, no appropriate NOAEL was available and additional data are required. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been...

  17. Scientific Opinion on Flavouring Group Evaluation 220 Revision 3 (FGE.220Rev3): Consideration of genotoxic potential for α,β-unsaturated 3(2H)-Furanones from subgroup 4.4 of FGE.19

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 10 flavouring substances from FGE.19 subgroup 4.4, in the Flavouring Group Evaluation 220 (FGE.220). FGE.220 is subdivided...... into two subgroups: subgroup 4.4a containing [FL-no: 13.089, 13.117, 13.119, 13.157 and 13.175] and subgroup 4.4b containing [13.010, 13.084 and 13.085, 13.099 and 13.176]. For both subgroups the Panel concluded that the genotoxicity alert could not be ruled out based on the data available and accordingly...... additional genotoxicity data were requested. In FGE.220, Revision 1, the Panel concluded that for the substances in subgroup 4.4b there is no concern for genotoxicity. In FGE.220, Revision 2, the Panel evaluated genotoxicity studies on two representative substances of subgroup 4.4a: 2,5-dimethylfuran-3(2H...

  18. Radiation protection in medicine 2002. Guide to radiation protection in the use of ionizing radiation (Strahlenschutzverordnung - StrlSchV). Revised edition with detailed explanations. 5. tot. new rev. and enl. ed.

    International Nuclear Information System (INIS)

    Kemmer, W.; Michalczak, H.

    2003-01-01

    Full text of the Guide to RAdiation Protection in Medicine; list of essential items to be considered when applying for a licence for the handling of sealed or unsealed radioactives substances; hints and instructions concerning application forms in procedures for thelicensing of installations for the generation of ionizing radiation; rules concerning inspection deadlines for testing the impermeability of the packing of sealed radioactive substances; list of the supervisory authorities of the German states responsible for supervision in the medical field; DIN norms and drafts relating to radiology

  19. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 300, Revision 1 (FGE.300Rev1): One cyclo-aliphatic amide from chemical group 33

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Frandsen, Henrik Lauritz; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate a flavouring substance,cyclopropanecarboxylic acid (2-isopropyl-5-methyl-cyclohexyl)-amide [FL-no: 16.115] in the Flavouring Group Evaluation 300, Revision 1....... The substance was not considered to have genotoxic potential. The substance was evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity....... The Panel concluded that the substance [FL-no: 16.115] does not give rise to safety concern at its levels of dietary intake estimated on the basis of the Maximised Survey-derived Daily Intake MSDI approach. Besides the safety assessment of this flavouring substance, the specifications for the material...

  20. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 28 flavouring substances in the Flavouring Group Evaluation 17, including seven additional substances considered in this Revision 3, using the Procedure......-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that 24 substances [FL-no: 14.057, 14.081, 14.083, 14.084, 14.086, 14.087, 14.091, 14.097, 14.099, 14.101, 14.102, 14.108, 14.109, 14.111, 14.112, 14.113, 14.122, 14...... substances, the specifications for the materials of commerce have also been considered and for one substance [FL-no: 14.102], the composition of mixture has not been specified sufficiently....

  1. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring substituted phenolic substances from chemical groups 21 and 25

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 28 flavouring substances in the Flavouring Group Evaluation 22, Revision 1, using the Procedure in Commission Regulation (EC) No 1565/2000. The substance 3...... through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that these 27 candidate substances do not give rise to safety...... concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. Adequate specifications for the materials of commerce are available for all 27 flavouring substances evaluated through the Procedure....

  2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FEG.17Rev2): Pyrazine derivatives from chemical group 24

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 21 flavouring substances in the Flavouring Group Evaluation 17, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. From the in vitro...... substance [FL-no: 14.051] no intake data are available preventing it from being evaluated through the Procedure. The remaining 18 substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold...... intake, estimated on the basis of the MSDI approach. For the remaining substance [FL-no: 14.052] additional toxicity data are required. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered and for two substances...

  3. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 10, Revision 3 (FGE.10Rev3): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 63 flavouring substances in the Flavouring Group Evaluation 10, including additional two substances in this Revision 3, using the Procedure in Commission...... threshold of concern, and available data on metabolism and toxicity. The Panel concluded that the 62 substances do not give rise to safety concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications...... for the materials of commerce have also been considered. For four substances evaluated through the Procedure, the stereoisomeric composition has not been specified sufficiently....

  4. Administrative Circular No. 26 (Rev.10) - Recognition of merit

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 26 (Rev. 10) entitled “Recognition of Merit”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to staff members. It cancels and replaces Administrative Circular No. 26 (Rev. 9) entitled “Recognition of Merit” of December 2011. The circular was revised in order to take into account the work performed in the framework of an elective mandate during the exercise of merit recognition of staff members. In addition, the circular was revised to provide that, in the case of staff members on special leave for professional reasons for a period equal to or longer than half a year, it will no longer be possible to grant an exceptional advancement. Department Head Office HR Department

  5. The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency. Latest Status (Chinese Edition)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1979-03-15

    The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency were approved by the Board of Governors on 21 February 1979. The test is reproduced herein for the information of all Members. The provisions established by the Board of Governors on 24 September 1977 for the application of safeguards in relation to the granting of technical assistance are also reproduced in the Annex to the Revised Guiding Principles and General Operating Rules.

  6. The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency. Latest Status (Spanish Edition)

    International Nuclear Information System (INIS)

    1979-03-01

    The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency were approved by the Board of Governors on 21 February 1979. The test is reproduced herein for the information of all Members. The provisions established by the Board of Governors on 24 September 1977 for the application of safeguards in relation to the granting of technical assistance are also reproduced in the Annex to the Revised Guiding Principles and General Operating Rules. [es

  7. The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency. Latest Status (Chinese Edition)

    International Nuclear Information System (INIS)

    1979-03-01

    The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency were approved by the Board of Governors on 21 February 1979. The test is reproduced herein for the information of all Members. The provisions established by the Board of Governors on 24 September 1977 for the application of safeguards in relation to the granting of technical assistance are also reproduced in the Annex to the Revised Guiding Principles and General Operating Rules.

  8. The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency. Latest Status (Arabic Edition)

    International Nuclear Information System (INIS)

    1979-03-01

    The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency were approved by the Board of Governors on 21 February 1979. The test is reproduced herein for the information of all Members. The provisions established by the Board of Governors on 24 September 1977 for the application of safeguards in relation to the granting of technical assistance are also reproduced in the Annex to the Revised Guiding Principles and General Operating Rules.

  9. The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency. Latest Status (French Edition)

    International Nuclear Information System (INIS)

    1979-03-01

    The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency were approved by the Board of Governors on 21 February 1979. The test is reproduced herein for the information of all Members. The provisions established by the Board of Governors on 24 September 1977 for the application of safeguards in relation to the granting of technical assistance are also reproduced in the Annex to the Revised Guiding Principles and General Operating Rules. [fr

  10. The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency. Latest Status (Russian Edition)

    International Nuclear Information System (INIS)

    1979-03-01

    The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency were approved by the Board of Governors on 21 February 1979. The test is reproduced herein for the information of all Members. The provisions established by the Board of Governors on 24 September 1977 for the application of safeguards in relation to the granting of technical assistance are also reproduced in the Annex to the Revised Guiding Principles and General Operating Rules. [ru

  11. ENDF/B-5 formats manual. Revised update pages of Nov. 1983. Reprint of B.A. Magurno, BNL-NCS--50496 (ENDF-102) 2nd Edition

    Energy Technology Data Exchange (ETDEWEB)

    Magurno, B A

    1986-09-01

    The ENDF-5 Format, originally the format of the US Evaluated Nuclear Data File ENDF/B-5, was internationally recommended for the computer storage, processing and exchange of evaluated neutron nuclear data. The pages included in this document serve as an update to the original ENDF-5 Formats Manual BNL-NCS-50496 [ENDF-102] 2nd Edition, October 1979. (author)

  12. Biological fundamentals. 2. completely rev. ed

    Energy Technology Data Exchange (ETDEWEB)

    Sahm, H. (ed.) (Forschungszentrum Juelich GmbH (Germany). Inst. fuer Biotechnologie)

    1993-01-01

    This fully revised and expanded Second Edition takes into account all recent developments in biotechnology. It is extraordinarily broad in scope, up-to-date, carefully structured and wellbalanced. 'Biotechnology' considers both basic concepts and widely-differing industrial applications: It is a successful synthesis of theory and practice. Any scientist aiming for success in industrial microbiology, biochemistry, molecular biology and chemical engineering must turn to 'Biotechnology'. Everybody involved in biotechnology will appreciate having this volume at their fingertips. It offers a unique collection of current information on the basic biology (ecology, taxonomy, biochemistry, physiology, and genetics) of industrially important organisms. This book contains the background material indispensable for the development of biotechnological processes. Topics included are: - Cell Structure, - Metabolism, - Growth of Microorganisms, - Metabolic Design, - Immobilized Organisms, - Methylotrophs, - Pseudomonas, - Yeasts, - Filamentous Fungi, - Bacteriophages, - Cell Cultures. (orig.)

  13. RevManHAL: towards automatic text generation in systematic reviews.

    Science.gov (United States)

    Torres Torres, Mercedes; Adams, Clive E

    2017-02-09

    Systematic reviews are a key part of healthcare evaluation. They involve important painstaking but repetitive work. A major producer of systematic reviews, the Cochrane Collaboration, employs Review Manager (RevMan) programme-a software which assists reviewers and produces XML-structured files. This paper describes an add-on programme (RevManHAL) which helps auto-generate the abstract, results and discussion sections of RevMan-generated reviews in multiple languages. The paper also describes future developments for RevManHAL. RevManHAL was created in Java using NetBeans by a programmer working full time for 2 months. The resulting open-source programme uses editable phrase banks to envelop text/numbers from within the prepared RevMan file in formatted readable text of a chosen language. In this way, considerable parts of the review's 'abstract', 'results' and 'discussion' sections are created and a phrase added to 'acknowledgements'. RevManHAL's output needs to be checked by reviewers, but already, from our experience within the Cochrane Schizophrenia Group (200 maintained reviews, 900 reviewers), RevManHAL has saved much time which is better employed thinking about the meaning of the data rather than restating them. Many more functions will become possible as review writing becomes increasingly automated.

  14. Schering dictionary of radiology. 3. tot. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Zink, C.

    2005-01-01

    Sixteen years after the first edition, the new edition takes account of the dramatic developments in medical imaging. All entries have been revised, and the number of entries has been increased considerably. Special attention was given to magnetic resonance tomography and the many options of image-assisted interventions. Modern methods of nuclear medical diagnosis and radiotherapy were considered as well as new legal regulations on radiation protection. More entries dealing with clinical medicine and instructive case studies enable readers to get an even closer view at radiology in theory and practice. (orig.)

  15. Tough Choices or Tough Times: The Report of the New Commission on the Skills of the American Workforce. Revised and Expanded Edition

    Science.gov (United States)

    Jossey-Bass, An Imprint of Wiley, 2008

    2008-01-01

    "Tough Choices or Tough Times," the report of the New Commission on the Skills of the American Workforce, shows how the dynamics of the global economy will lead to a steady decline in the American standard of living if this country does not undertake the first thorough overhaul of its education system in a century. This new revised and expanded…

  16. When Gifted Kids Don't Have All the Answers: How to Meet Their Social and Emotional Needs. Revised and Updated Edition

    Science.gov (United States)

    Galbraith, Judy; Delisle, Jim

    2015-01-01

    Gifted kids are so much more than test scores and grades. Still, it's sometimes difficult to see past the potential to the child who may be anxious, lonely, confused, or unsure of what the future might bring. This book, now fully revised with updated information and new survey quotes, offers practical suggestions for addressing the social and…

  17. Managing the Incompetent Teacher. Second Edition.

    Science.gov (United States)

    Bridges, Edwin M.

    Featuring the same practical guidelines for ridding schools of incompetent teachers as the 1984 edition, this new edition incorporates substantially revised material on three topics: criteria and information sources for evaluating teaching effectiveness, remediation procedures, and grounds for dismissal. The book presents an eight-step systematic,…

  18. Accounting for Independent Schools. Second Edition.

    Science.gov (United States)

    National Association of Independent Schools, Boston, MA.

    This is a thoroughly revised edition of the 1969 publication, "Accounting for Independent Schools," a guide that attempted to codify basic accounting principles and practices for specific application to independent schools. The focus of the second edition is more on refining practices than on initiating them, and more on extending the managerial…

  19. Administrative Circular No. 23 (Rev. 4) - Special working hours

    CERN Document Server

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 23 (Rev. 4) entitled "Special working hours", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208539.   This revised circular cancels and replaces Administrative Circular No. 23 (Rev. 3) also entitled "Special working hours" of January 2013. This document contains modifications to reflect the new career structure and ensuring the provision consistent with practice that compensation or remuneration of special working hours performed remotely is possible only in case of emergency.   This circular will enter into force on 1st September 2016.

  20. Cardiovascular radiotherapy. A multi-disciplinary textbook. 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Hehrlein, C.

    2002-01-01

    Cardiovascular radiotherapy has made rapid progress over the past few years, thus necessitating a revision and re-edition of this textbook. The structure of the first edition has been largely retained, but there have nevertheless been some important new additions, including chapters on ''New insights on vessel thrombosis and the edge effect following vascular brachytherapy'', ''Catheter-based intracoronary brachytherapy using the β emitter phosphorus 32'', ''Intracoronary afterloading using the Novoste trademark system'' and ''Catheter-based γ-HDR brachytherapy of the peripheral vessels''. The contributions contained in the first edition have also been thoroughly revised

  1. Radiology trainer. Surgical ambulance. Revision 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Ackermann, Ole; Barkhausen, Joerg

    2013-01-01

    The radiology trainer for surgical ambulance includes informative X-ray imaging examples for the following issues: zygoma, nasal bone, spinal cord, clavicle, shoulder, upper arms, elbow, forearms, wrist, hand, phalanx, thorax, sternum, pelvis, abdomen, hips, femur, knee, lower leg, ankle, feet.

  2. Environmental impact data for fuels. Part 1: Main report. Resource consumption and emissions from the entire life cycle (New revised edition)

    International Nuclear Information System (INIS)

    Uppenberg, S.; Almemark, M.; Brandel, M.; Lindfors, L.G.; Marcus, H.O.; Stripple, H.; Wachtmeister, A.; Zetterberg, L.

    2001-05-01

    This report is a compilation of data concerning environmental impacts from the utilization of different fuels. The entire life cycle is studied, from the extraction of raw materials to combustion. The fuels under study are gasoline, gasoline with MTBE, diesel, fuel oil, LPG, coal, natural gas, peat, refuse, ethanol, RME, DME, methane and wood fuels (forestry residues, Salix, pellets/briquettes). Utilization areas studied are heating plants, cogeneration plants, power plants, domestic boilers, and light and heavy vehicles. In this new edition, the following changes were made: New life cycle analyses have been included, a few new fuels added, electricity from hydroelectric plants, wind power plants and nuclear power plants have been included and some other minor changes

  3. Revising the personality disorder diagnostic criteria for the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-V): consider the later life context.

    Science.gov (United States)

    Balsis, Steve; Segal, Daniel L; Donahue, Cailin

    2009-10-01

    The categorical measurement approach implemented by the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) personality disorder (PD) diagnostic system is theoretically and pragmatically limited. As a result, many prominent psychologists now advocate for a shift away from this approach in favor of more conceptually sound dimensional measurement. This shift is expected to improve the psychometric properties of the personality disorder (PD) diagnostic system and make it more useful for clinicians and researchers. The current article suggests that despite the probable benefits of such a change, several limitations will remain if the new diagnostic system does not closely consider the context of later life. A failure to address the unique challenges associated with the assessment of personality in older adults likely will result in the continued limited validity, reliability, and utility of the Diagnostic and Statistical Manual of Mental Disorders (DSM) system for this growing population. This article discusses these limitations and their possible implications. (c) 2009 APA, all rights reserved.

  4. Guidelines for the Review of Research Reactor Safety: Revised Edition. Reference Document for IAEA Integrated Safety Assessment of Research Reactors (INSARR)

    International Nuclear Information System (INIS)

    2013-01-01

    The Integrated Safety Assessment of Research Reactors (INSARR) is an IAEA safety review service available to Member States with the objective of supporting them in ensuring and enhancing the safety of their research reactors. This service consists of performing a comprehensive peer review and an assessment of the safety of the respective research reactor. The reviews are based on IAEA safety standards and on the provisions of the Code of Conduct on the Safety of Research Reactors. The INSARR can benefit both the operating organizations and the regulatory bodies of the requesting Member States, and can include new research reactors under design or operating research reactors, including those which are under a Project and Supply Agreement with the IAEA. The first IAEA safety evaluation of a research reactor operated by a Member State was completed in October 1959 and involved the Swiss 20 MW DIORIT research reactor. Since then, and in accordance with its programme on research reactor safety, the IAEA has conducted safety review missions in its Member States to enhance the safety of their research reactor facilities through the application of the Code of Conduct on the Safety of Research Reactors and the relevant IAEA safety standards. About 320 missions in 51 Member States were undertaken between 1972 and 2012. The INSARR missions and other limited scope safety review missions are conducted following the guidelines presented in this publication, which is a revision of Guidelines for the Review of Research Reactor Safety (IAEA Services Series No. 1), published in December 1997. This publication details those IAEA safety standards and guidance publications relevant to the safety of research reactors that have been revised or published since 1997. The purpose of this publication is to give guidance on the preparation, implementation, reporting and follow-up of safety review missions. It is also intended to be of assistance to operators and regulators in conducting

  5. The structure of Diagnostic and Statistical Manual of Mental Disorders (4th edition, text revision) personality disorder symptoms in a large national sample.

    Science.gov (United States)

    Trull, Timothy J; Vergés, Alvaro; Wood, Phillip K; Jahng, Seungmin; Sher, Kenneth J

    2012-10-01

    We examined the latent structure underlying the criteria for DSM-IV-TR (American Psychiatric Association, 2000, Diagnostic and statistical manual of mental disorders (4th ed., text revision). Washington, DC: Author.) personality disorders in a large nationally representative sample of U.S. adults. Personality disorder symptom data were collected using a structured diagnostic interview from approximately 35,000 adults assessed over two waves of data collection in the National Epidemiologic Survey on Alcohol and Related Conditions. Our analyses suggested that a seven-factor solution provided the best fit for the data, and these factors were marked primarily by one or at most two personality disorder criteria sets. A series of regression analyses that used external validators tapping Axis I psychopathology, treatment for mental health problems, functioning scores, interpersonal conflict, and suicidal ideation and behavior provided support for the seven-factor solution. We discuss these findings in the context of previous studies that have examined the structure underlying the personality disorder criteria as well as the current proposals for DSM-5 personality disorders. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  6. Quantum mechanics. Vol. 1. 4. rev. upd. ed.

    International Nuclear Information System (INIS)

    Cohen-Tannoudji, Claude; Diu, Bernard; Laloe, Franck

    2009-01-01

    The translation of the known French work of Nobel-price winner Cohen-Tannoudji and his co-authors Diu and Laloe introduces studyings of physics and natural sciences into the terms of quantum mechanics. After the positive acception of the first three editions of this textbook in German language the work now appears in fourth revised and improved edition. Each chapter consists of two parts. In the first part the basic postulates and terms are presented and developed. Teh second part - the supplements - mediates by means of numerous exercise problems and examples the handling of the basic quantum-mechanical knowledge. By this the work is at the same time a text and exercise book, which also, in the occupational praxis is useful as reference book

  7. Radiotherapy and radiooncology: An interdisciplinary approach. 4. tot. new rev. and enl. ed.

    International Nuclear Information System (INIS)

    Karstens, J.H.; Bremer, M.; Meyer, A.; Warszawski, A.; Bruns, F.

    2005-01-01

    This is the 4th, completely revised edition of the successful book on modern cancer therapy. The focus of this edition is on interdisciplinary cooperation. Current knowledge, both legal and medical, is presented in a clear and well-structured form. The text is supplemented by many illustrative drawings and pictures. The book addresses students and other readers interested in oncology and provides useful and detailed information on radiation therapy of benign and malignant diseases. (orig.)

  8. Optimized Chemical Probes for REV-ERBα

    OpenAIRE

    Trump, Ryan P.; Bresciani, Stefano; Cooper, Anthony W. J.; Tellam, James P.; Wojno, Justyna; Blaikley, John; Orband-Miller, Lisa A.; Kashatus, Jennifer A.; Dawson, Helen C.; Loudon, Andrew; Ray, David; Grant, Daniel; Farrow, Stuart N.; Willson, Timothy M.; Tomkinson, Nicholas C. O.

    2013-01-01

    REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability. Potent REV-ERBα agonists 4, 10, 16, and 23 are detailed for their ability to suppress BMAL and IL-6 expression from human cells while also demonstrating excellent selectivity over LXRα. Amine 4 demonstrated in vivo bioavailability after either IV o...

  9. Studies on Neotropical Phasmatodea XVI: Revision of Haplopodini Günther, 1953 (rev. stat.), with notes on the subfamily Cladomorphinae Bradley & Galil, 1977 and the descriptions of a new tribe, four new genera and nine new species (Phasmatodea: "Anareolatae": Phasmatidae: Cladomorphinae).

    Science.gov (United States)

    Hennemann, Frank H; Conle, Oskar V; Perez-Gelabert, Daniel E

    2016-06-27

    eggs. Haplopodini Günther, 1953 is re-established (rev. stat.) and comprises almost exclusively Caribbean genera previously placed in Hesperophasmatini by Bradley & Galil (1977) or Cranidiini by Zompro, (2004). Aploploides Rehn & Hebard, 1938, Diapherodes Gray, 1835, Haplopus Burmeister, 1838 and Paracranidium Brock, 1998 were misplaced in Cranidiini and are transferred to Haplopodini. On the basis of numerous morphological characters of the insects and eggs Hesperophasmatini is removed from Pseudophasmatidae: Xerosomatinae and re-transferred to its previous position in the subfamily Cladomorphinae sensu lato. A detailed newdiagnosis of Hesperophasmatini is presented, but is only provisional since the true diversity is as yet only fractionally known. The lack of a gula distinguishes Hesperophasmatini from all other tribes. The genus Laciphorus Redtenbacher, 1908 is removed from Hesperophasmatini and transferred to Diapheromeridae: Diapheromerinae: Diapheromerini. The new tribe Pterinoxylini n. trib. is established to contain only the type-genus Pterinoxylus Audinet-Serville, 1838. It is closely related and perhaps the sister taxon of Hesperophasmatini, with which it shares the presence of rough sensory areas on the probasisternum and profurcasternum. It differs from Hesperophasmatini and Haplopodini by the presence of a tympanal region (= stridulatory organ) in the alae of females and the alveolar eggs, which possess peripheral opercular and polar structures. Haplopodini is likely to be the sister group of Pterinoxylini n. trib. + Hesperophasmatini.        The tribe Haplopodini rev. stat. is revised at the species level and comprises eight almost exclusively Caribbean genera, four of which are newly described. All eight genera now contained in Haplopodini are described in detail, differentiated from their closest relatives and their relationships and systematic position within Haplopodini are discussed. Keys and maps showing their distributions are presented

  10. Principles of veterinary radiography. 2. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Douglas, S.W.; Herrtage, M.E.; Williamson, H.D.

    1991-01-01

    This book by Douglas and Williamson about the physical-technical fundamentals of radiology in veterinary medicine was first published in 1977 and the second edition now available has been revised and enlarged. Part 1 gives coverage of the basic physical and technical requirements of the necessary equipment and installations as well as the laws governing radiation protection. In Part 2, exposure techniques and special examinations procedures are described in detail. Contrast-enhanced examinations are dealt with exhaustively. (orig./MG) With 166 figs., 10 tabs [de

  11. An introduction to radioimmunoassay and related techniques. 3. rev. ed.

    International Nuclear Information System (INIS)

    Chard, T.

    1987-01-01

    This book is designed as an introductory text for the staff of clinical or research laboratories who conduct or intend to conduct radioimmunoassay and related immunoassay techniques, and will also be of great value to the clinicians who make use of such services. The emphasis is on general principles with practical illustrations rather than a detailed and encyclopaedic review of the literature. This 3rd revised edition places more emphasis on alternative labels (non-isotopic immunoassays), the use of labelled antibodies (immunometric assays), and the use of monoclonal antibodies. Both principles and practice are illustrated by diagrams and illustrations. (Auth.)

  12. Cluster editing

    DEFF Research Database (Denmark)

    Böcker, S.; Baumbach, Jan

    2013-01-01

    . The problem has been the inspiration for numerous algorithms in bioinformatics, aiming at clustering entities such as genes, proteins, phenotypes, or patients. In this paper, we review exact and heuristic methods that have been proposed for the Cluster Editing problem, and also applications......The Cluster Editing problem asks to transform a graph into a disjoint union of cliques using a minimum number of edge modifications. Although the problem has been proven NP-complete several times, it has nevertheless attracted much research both from the theoretical and the applied side...

  13. Administrative Circular No. 22B (Rev. 2) - Compensation for hours of long-term shift work

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 22B (Rev. 2) entitled "Compensation for hours of long-term shift work",  approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208538.   This revised circular cancels and replaces Administrative Circular No. 22B (Rev. 1) also entitled "Compensation for hours of long-term shift work" of March 2011. This document contains minor changes to reflect the new career structure. This circular will enter into force on 1st September 2016.

  14. Administrative Circular No. 13 (Rev. 4) - Guarantees for representatives of the personnel

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 13 (Rev. 4) entitled "Guarantees for representatives of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208527.   This revised circular cancels and replaces Administrative Circular No. 13 (Rev. 3) also entitled "Guarantees for representatives of the personnel" of January 2014. This document contains a single change to reflect the terminology under the new career structure: the term "career path" is replaced by "grade". This circular will enter into force on 1st September 2016.

  15. Administrative Circular No. 11 (Rev. 4) - Categories of members of the personnel

    CERN Multimedia

    HR Department

    2016-01-01

    Administrative Circular No. 11 (Rev. 4) entitled "Categories of members of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 29 April 2016, will be available on 1 August 2016 via this following link.    This revised circular cancels and replaces the Administrative Circular No. 11 (Rev. 3) also entitled "Categories of members of the personnel" of September 2014. The main changes concern the status of apprentices and their transfer from the category of employed members of personnel to associated members of personnel. This circular will enter into force on 1 August 2016. Department Head Office

  16. Pediatric uroradiology. 2nd rev. ed.

    International Nuclear Information System (INIS)

    Fotter, Richard

    2008-01-01

    Since the first edition of Pediatric Uroradiology, very significant advances have been made in the imaging and treatment of common and important pediatric urologic disorders such as vesicoureteric reflux, urinary tract infection, and upper urinary tract dilatation. This revised and extended version takes full account of the sometimes dramatic changes. Where appropriate, new contents have been included, e.g., on genetics, while other information that continues to be pertinent has been retained. This book describes in detail all aspects of pediatric uroradiology. While it is written primarily from the point of view of the radiologist, it includes essential information for the pediatrician, pediatric surgeon, and urologist. It is specifically designed to aid the clinician in decisions on imaging management. The newest techniques and the changing relevance of imaging and interventional procedures are presented, and the diverse problems associated with the changing anatomy, physiology, and pathophysiology from the newborn period to adulthood are explained. The whole spectrum of imaging features of agenesis, anomalies, dysplasia, parenchymal diseases, neoplastic diseases, stone disease, renal vascular hypertension, renal failure, renal transplantation, and genitourinary trauma is covered. Individual chapters are devoted to vesicoureteric reflux, urinary tract infection, upper urinary tract dilatation, voiding dysfunction, and neurogenic bladder. A new chapter on the clinical management of common nephrourologic disorders, with the subtitle ''guidelines and beyond,'' explains how imaging is embedded in the whole process of clinical management today. Short conclusions are included at the end of chapters and sections to provide the reader with the key information on the specific topic under consideration. (orig.)

  17. Pediatric uroradiology. 2nd rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Fotter, Richard (ed.) [Univ. Hospital Medical Univ. Graz (Austria). Div. of Pediatric Radiology

    2008-07-01

    Since the first edition of Pediatric Uroradiology, very significant advances have been made in the imaging and treatment of common and important pediatric urologic disorders such as vesicoureteric reflux, urinary tract infection, and upper urinary tract dilatation. This revised and extended version takes full account of the sometimes dramatic changes. Where appropriate, new contents have been included, e.g., on genetics, while other information that continues to be pertinent has been retained. This book describes in detail all aspects of pediatric uroradiology. While it is written primarily from the point of view of the radiologist, it includes essential information for the pediatrician, pediatric surgeon, and urologist. It is specifically designed to aid the clinician in decisions on imaging management. The newest techniques and the changing relevance of imaging and interventional procedures are presented, and the diverse problems associated with the changing anatomy, physiology, and pathophysiology from the newborn period to adulthood are explained. The whole spectrum of imaging features of agenesis, anomalies, dysplasia, parenchymal diseases, neoplastic diseases, stone disease, renal vascular hypertension, renal failure, renal transplantation, and genitourinary trauma is covered. Individual chapters are devoted to vesicoureteric reflux, urinary tract infection, upper urinary tract dilatation, voiding dysfunction, and neurogenic bladder. A new chapter on the clinical management of common nephrourologic disorders, with the subtitle 'guidelines and beyond,' explains how imaging is embedded in the whole process of clinical management today. Short conclusions are included at the end of chapters and sections to provide the reader with the key information on the specific topic under consideration. (orig.)

  18. Carlsbad Area Office strategic plan, March 1995. Revision 1

    International Nuclear Information System (INIS)

    1995-03-01

    This edition of the Carlsbad Area Office Strategic Plan captures the US Department of Energy's (DOE's) new focus, and supersedes the edition issued previously (DOE, 1993a). This revision reflects: a revised strategy designed to demonstrate compliance with environmental regulations earlier than the previous course of action; and a focus on establishment of standardized transuranic waste characterization and acceptance criteria for disposal facilities

  19. Single-edition quadrangle maps

    Science.gov (United States)

    ,

    1998-01-01

    In August 1993, the U.S. Geological Survey's (USGS) National Mapping Division and the U.S. Department of Agriculture's Forest Service signed an Interagency Agreement to begin a single-edition joint mapping program. This agreement established the coordination for producing and maintaining single-edition primary series topographic maps for quadrangles containing National Forest System lands. The joint mapping program saves money by eliminating duplication of effort by the agencies and results in a more frequent revision cycle for quadrangles containing national forests. Maps are revised on the basis of jointly developed standards and contain normal features mapped by the USGS, as well as additional features required for efficient management of National Forest System lands. Single-edition maps look slightly different but meet the content, accuracy, and quality criteria of other USGS products. The Forest Service is responsible for the land management of more than 191 million acres of land throughout the continental United States, Alaska, and Puerto Rico, including 155 national forests and 20 national grasslands. These areas make up the National Forest System lands and comprise more than 10,600 of the 56,000 primary series 7.5-minute quadrangle maps (15-minute in Alaska) covering the United States. The Forest Service has assumed responsibility for maintaining these maps, and the USGS remains responsible for printing and distributing them. Before the agreement, both agencies published similar maps of the same areas. The maps were used for different purposes, but had comparable types of features that were revised at different times. Now, the two products have been combined into one so that the revision cycle is stabilized and only one agency revises the maps, thus increasing the number of current maps available for National Forest System lands. This agreement has improved service to the public by requiring that the agencies share the same maps and that the maps meet a

  20. Repository Surface Design Engineering Files Report Rev 00 ICN 1

    International Nuclear Information System (INIS)

    2001-01-01

    The objective of the Repository Surface Design Engineering Files Report Supplement [herein known as the Engineering Files (EF)] is to provide the surface design data needed by the Environmental Impact Statement (EIS) contractor to prepare the EIS and evaluate options and alternatives. This document is based on the Repository Surface Design Engineering Files Report, Revision 03 (CRWMS M and O 1999f) (EF Rev 03). Where facility and system designs have been changed for the Site Recommendation (SR) effort they are described in this report. EIS information provided in this report includes the following: (1) Description of program phases; there are no changes that impact this report. (2) A description of the major design requirements and assumptions that drive the surface facilities reference design is provided herein (Section 2.2), including the surface design resulting from recommendations regarding Enhanced Design Alternative (EDA) II, as discussed in the License Application Design Section Report (CRWMS M and O 1999d), and changes to the waste stream. See Section 2, Table 2-2, for the SR waste stream. (3) The major design requirements and assumptions that drive the surface facilities reference design are by reference to EF Rev 03; there are no changes that impact this report. (4) Description of the reference design concept and existing site conditions is by reference to EF Rev 03 (including Table 4-1, which is not included in this supplement); there are no changes that impact this report. (5) Description of alternative design cases is by reference to EF Rev 03; there are no changes that impact this report. (6) Description of optional inventory modules is by reference to EF Rev 03; there are no changes that impact this report. (7) Tabular summary level engineering values (i.e., staffing, wastes, emissions, resources, and land use) for the reference design and the alternative design cases that address construction, emplacement operations, caretaker operations, and

  1. The Cambridge encyclopedia of space (revised edition)

    Science.gov (United States)

    D'Allest, Frederic; Arets, Jean; Baker, Phillip J.; Balmino, Georges; Barth, Hans; Benson, Robert H.

    1990-01-01

    A comprehensive and intensively illustrated development history is presented for spaceflight, ranging over its basic concepts' speculative and fictional origins, the historical roots of rocket-related technologies, and the scientific accomplishments of earth orbit and interplanetary missions to date. Attention is given to propulsion systems, spaceflight launch centers, satellite systems, and solar system exploration by the U.S. and the Soviet Union. Current space-related activities encompass the meteorology, remote sensing, telecommunications and direct broadcasting, and navigation functions of unmanned satellites, as well as such manned spacecraft roles as medical and materials science research. The military uses of space, and increasingly important space industrialization concepts, are discussed as well.

  2. World Hunger: Ten Myths. Fourth Edition, Revised.

    Science.gov (United States)

    Lappe, Frances Moore; Collins, Joseph

    Although there are a number of complex political, economic, and ecological issues at the root of world hunger, a number of myths have been perpetuated to explain why hunger exists. One myth says that people are hungry because of scarcity; in fact, hunger exists in the face of plenty. The earth is producing more than enough to nourish every human…

  3. Public Affairs Manual. Revised 1976 Edition.

    Science.gov (United States)

    American Alliance for Health, Physical Education, and Recreation, Washington, DC.

    This public affairs manual is designed for health, physical education, and recreation personnel. It begins with a position statement by the American Alliance for Health, Physical Education, and Recreation (AAHPER). In section two, resources and procedures for crises action at the local and state level are discussed. Several organizational models…

  4. Laboratory Waste Disposal Manual. Revised Edition.

    Science.gov (United States)

    Stephenson, F. G., Ed.

    This manual is designed to provide laboratory personnel with information about chemical hazards and ways of disposing of chemical wastes with minimum contamination of the environment. The manual contains a reference chart section which has alphabetical listings of some 1200 chemical substances with information on the health, fire and reactivity…

  5. University Physics, Study Guide, Revised Edition

    Science.gov (United States)

    Benson, Harris

    1996-01-01

    Partial table of contents: Vectors. One-Dimensional Kinematics. Particle Dynamics II. Work and Energy. Linear Momentum. Systems of Particles. Angular Momentum and Statics. Gravitation. Solids and Fluids. Oscillations. Mechanical Waves. Sound. First Law of Thermodynamics. Kinetic Theory. Entropy and the Second Law of Thermodynamics. Electrostatics. The Electric Field. Gauss's Law. Electric Potential. Current and Resistance. The Magnetic Field. Sources of the Magnetic Field. Electromagnetic Induction. Light: Reflection and Refraction. Lenses and Optical Instruments. Wave Optics I. Special Relativity. Early Quantum Theory. Nuclear Physics. Appendices. Answers to Odd-Numbered Exercises and Problems. Index.

  6. China energy databook. Revision 2, 1992 edition

    Energy Technology Data Exchange (ETDEWEB)

    Sinton, J.E.; Levine, M.D.; Liu, Feng; Davis, W.B. [eds.] [Lawrence Berkeley Lab., CA (United States); Jiang Zhenping; Zhuang Xing; Jiang Kejun; Zhou Dadi [eds.] [State Planning Commission of China, Beijing, BJ (China). Energy Research Inst.

    1993-06-01

    The Energy Analysis Program at the Lawrence Berkeley Laboratory (LBL) first became involved in Chinese energy issues through a joint China-US symposium on markets and demand for energy held in Nanjing in November of 1988. Discovering common interests, EAP began to collaborate on projects with the Energy Research Institute of China`s State Planning Commission. In the course of this work it became clear that a major issue in the furtherance of our research was the acquisition of reliable data. In addition to other, more focused activities-evaluating programs of energy conservation undertaken in China and the prospects for making Chinese industries more energy-efficient, preparing historical reviews of energy supply and demand in the People`s Republic of China, sponsoring researchers from China to work with experts at LBL on such topics as energy efficiency standards for buildings, adaptation of US energy analysis software to Chinese conditions, and transportation issues, we decided to compile, assess, and organize Chinese energy data. We are hopeful that this volume will not only help us in our work, but help build a broader community of Chinese energy policy studies within the US. In order to select appropriate data from what was available we established several criteria. Our primary interest was to use the data to help understand the historical evolution and likely future of the Chinese energy system. A primary criterion was thus that the data relate to the structure of energy supply and demand in the past and indicate probable developments (e.g., as indicated by patterns of investment). Other standards were accuracy, consistency with other information, and completeness of coverage. This is not to say that all the data presented herein are accurate, consistent, and complete, but where discrepancies and omissions do occur we have tried to note them.

  7. Software Methodology Catalog. Second Edition. Revision

    Science.gov (United States)

    1989-03-01

    Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino, Italy [Developer] 3 I I I 3-149 I PROTOB 3.32.7 REFERENCES I [Brun86a] G. Bruno and G...Smalltalk, Mesa/XDE, Cedar, the Synthesizer Generator, Mentor, PDE, Syned, Pecan , Toolpack, Magpie, Cope, Poe, Rn, DICE, DOSE, UNIX, Cades, the

  8. Delivering Instruction to Adult Learners. Revised Edition.

    Science.gov (United States)

    Cantor, Jeffrey A.

    This one-stop guide for trainers and educators of adults in industry, business, or the professions details a results-oriented instructional strategy that is based on the following principles for instructing adults effectively: (1) act as a leader, helper, guide, change agent, coordinator, and facilitator of learning; (2) promote active…

  9. GUIDE FOR INMATE EDUCATION. REVISED EDITION.

    Science.gov (United States)

    WILKINSON, FRED T.

    AN EDUCATIONAL PROGRAM IN AN INSTITUTION CONCERNED WITH THE REHABILITATION OF AN INMATE MUST BE SOCIALLY AND VOCATIONALLY ORIENTED, WITH VOCATIONAL EMPHASIS ON THE TOTAL EDUCATIONAL PROCESS. SINCE THE MAJORITY OF INMATES ARE FUNCTIONALLY ILLITERATE, AND SINCE 90 PERCENT WILL EVENTUALLY RETURN TO SOCIETY, COURSES IN GENERAL EDUCATION ARE INTERWOVEN…

  10. Teaching Process Writing with Computers. Revised Edition.

    Science.gov (United States)

    Boone, Randy, Ed.

    Focusing on the use of word processing software programs as instructional tools for students learning writing composition, this collection includes 14 research articles and position papers, 16 reports on lesson ideas and projects, 5 articles on keyboarding, and 18 product reviews. These materials relate to teaching writing through the process…

  11. Discipline in the Classroom. Revised Edition.

    Science.gov (United States)

    National Education Association, Washington, DC.

    The articles in this booklet reflect a broad spectrum in their approach to discipline and the teaching process. Even though discipline is now called classroom control, these articles indicate that some educators question the desirability of precise prescription in the classroom. Running through the articles is a common thread: discipline is less…

  12. How to Use Eric. Revised Edition.

    Science.gov (United States)

    Griffin, Louise

    This booklet defines the ERIC system and gives directions on the use of "Research in Education." It also tells about the Eric Document Reproduction Service (EDRS), its use, and its products. In addition, it tells what types of materials ERIC Clearinghouses process. A list of the 19 Clearinghouses, with a description of their specific interests and…

  13. Graphic Design Career Guide 2. Revised Edition.

    Science.gov (United States)

    Craig, James

    The graphic design field is diverse and includes many areas of specialization. This guide introduces students to career opportunities in graphic design. The guide is organized in four parts. "Part One: Careers in Graphic Design" identifies and discusses the various segments of the graphic design industry, including: Advertising, Audio-Visual, Book…

  14. Diesel Fuel Systems. Teacher Edition (Revised).

    Science.gov (United States)

    Clark, Elton; Huston, Jane, Ed.

    This module is one of a series of teaching guides that cover diesel mechanics. The module contains six instructional units that cover the following topics: (1) introduction to fuel injection systems and components; (2) injection nozzles; (3) distributor type injection pumps; (4) unit injectors; (5) in-line injection pumps; and (6) pressure timed…

  15. Anatomy and Physiology. Revised Teacher Edition.

    Science.gov (United States)

    Hartman, Danene; And Others

    This curriculum guide contains 14 units of instruction for a course in anatomy and physiology for surgical technology students. The units cover the following topics: (1) organization of the body; (2) cells, tissues, and membranes; (3) integumentary system; (4) skeletal system; (5) muscular system; (6) nervous system; (7) special sense organs; (8)…

  16. ERIC User Services Manual. Revised Edition.

    Science.gov (United States)

    Wagner, Judith O., Comp.

    This manual explains how the user services functions, usually performed by a User Services Coordinator, can be conducted in the 16 ERIC (Educational Resources Information Center) Clearinghouses and the various adjunct ERIC Clearinghouses. It provides guidelines, suggestions, and examples of how ERIC components currently perform the user services…

  17. Clausewitzian Friction and Future War Revised Edition

    Science.gov (United States)

    2004-01-01

    Hanoverian general Rudolf von Hammerstein was ordered to occupy the town of Menin in southern Belgium, Scharnhorst served as his principal staff offi...their own files. 100 ENDNOTES FOR PAGES 38–41 156 The intractability of the traveling salesman, or Steiner shortest network, problem is as fol- lows...the class of “hard” problems epitomized by the Steiner problem remains “the preeminent problem in theoretical computer science” (Marshall W. Bern and

  18. Administrative circular n°11 (REV. 2) – Categories of members of the personnel

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 May 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department. This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 1) entitled “Categories of members of the personnel” of January 1997 as regards all contracts of members of the personnel issued on or after 1 January 2013. The circular was revised in order to take into account developments since the last revision of the categories of personnel in 1997 as well as the needs of the Organization and collaborating institutes. In particular, it introduces a new system for distinguishing categories of associated members of the personnel, namely with regard to the purpo...

  19. The Elgar companion to social economics : Second edition

    NARCIS (Netherlands)

    Davis, John B.; Dolfsma, Wilfred

    2015-01-01

    Social economics is a dynamic and growing field that emphasizes the key roles social values play in the economy and economic life. This second edition of the Elgar Companion to Social Economics revises all chapters from the first edition, and adds important new chapters to reflect the expansion and

  20. 75 FR 69921 - Trademark Manual of Examining Procedure, Seventh Edition

    Science.gov (United States)

    2010-11-16

    ... applications. The seventh edition incorporates USPTO trademark practice and relevant case law reported prior to September 1, 2010. The policies stated in this revision supersede any previous policies stated in prior editions, examination guides, or any other statement of USPTO policy, to the extent that there is any...

  1. Administrative Circular No. 2 (Rev. 7) - Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Multimedia

    2015-01-01

    Administrative Circular No. 2 (Rev. 7), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion at the Standing Concertation Committee meeting held on 17 February 2015 is available via the following link: AC No. 2 (Rev.7).   This revised circular cancels and replaces Administrative Circular No. 2 (Rev. 6), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" and dated January 2015. The circular was revised in order to implement the amendment to Article R II 1.17 of the Staff Regulations, which introduces the possibility of extending limited-duration (LD) contracts up to a maximum total duration of eight years from the previous duration of five years. The award of indefinite contracts will continue to be subject to the outcome of a competitive process. Department Head Of...

  2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific O pinion Flavouring Group Evaluation 23, Revision 4 (FGE.23Rev4): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 21 flavouring substances in the Flavouring Group Evaluation 23, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. This revision i...... also been considered. Specifications including complete purity criteria and identity for the materials of commerce have been provided for all 21 candidate substances. © European Food Safety Authority, 2013......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 21 flavouring substances in the Flavouring Group Evaluation 23, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. This revision...

  3. Handbook of Qualitative Research. Second Edition.

    Science.gov (United States)

    Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

    This handbook's second edition represents the state of the art for the theory and practice of qualitative inquiry. It features eight new topics, including autoethnography, critical race theory, applied ethnography, queer theory, and "testimonio"every chapter in the handbook has been thoroughly revised and updated. The book…

  4. Planning and Producing Audiovisual Materials. Third Edition.

    Science.gov (United States)

    Kemp, Jerrold E.

    A revised edition of this handbook provides illustrated, step-by-step explanations of how to plan and produce audiovisual materials. Included are sections on the fundamental skills--photography, graphics and recording sound--followed by individual sections on photographic print series, slide series, filmstrips, tape recordings, overhead…

  5. Atlas of enchocardiography, 2nd edition

    International Nuclear Information System (INIS)

    Salcedo, E.

    1985-01-01

    Completely revised and expanded, this new edition focuses on the interdependence of M-mode and two-dimensional echocardiography in diagnosing cardiac disorders. Systematically organized to facilitate locating information, the atlas follows the entire echocardiographic process from test through diagnosis. Illustrations and representative echocardiographs are included

  6. Measurement and Assessment in Teaching. Eighth Edition.

    Science.gov (United States)

    Linn, Robert L.; Gronlund, Norman E.

    This book is intended to introduce the classroom teacher and prospective teacher to the elements of measurement and assessment that are essential to good teaching. The main theme is that assessment plays an important role in the instructional process. This edition has been revised to reflect major changes in educational assessment since the last…

  7. Test Review: Wechsler Abbreviated Scale of Intelligence, Second Edition

    Science.gov (United States)

    Irby, Sarah M.; Floyd, Randy G.

    2013-01-01

    The Wechsler Abbreviated Scale of Intelligence, Second Edition (WASI-II; Wechsler, 2011) is a brief intelligence test designed for individuals aged 6 through 90 years. It is a revision of the Wechsler Abbreviated Scale of Intelligence (WASI; Wechsler, 1999). During revision, there were three goals: enhancing the link between the Wechsler…

  8. Multicultural Communities: Guidelines for Library Services. Third Edition

    Science.gov (United States)

    International Federation of Library Associations and Institutions (NJ1), 2009

    2009-01-01

    These Guidelines constitute the third edition of the International Federation of Library Associations (IFLA) "Multicultural Communities: "Guidelines for Library Services." This revision follows the IFLA Section of Library Services to Multicultural Populations' "2006-2010 Strategic Plans": to review and revise the…

  9. Quicklook overview of model changes in Melcor 2.2: Rev 6342 to Rev 9496

    Energy Technology Data Exchange (ETDEWEB)

    Humphries, Larry L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    MELCOR 2.2 is a significant official release of the MELCOR code with many new models and model improvements. This report provides the code user with a quick review and characterization of new models added, changes to existing models, the effect of code changes during this code development cycle (rev 6342 to rev 9496), a preview of validation results with this code version. More detailed information is found in the code Subversion logs as well as the User Guide and Reference Manuals.

  10. Expert knowledge in radiation protection. 2. rev. ed.

    International Nuclear Information System (INIS)

    Spang, A.

    1990-01-01

    This revised version of the first edition, which was published in 1983, incorporates the full scale of developments and changes made since then, as e.g.: the new Radiation Protection Ordinance, which introduces the concept and definition of effective dose, ED, and limits the maximum permissible occupational exposure to 400 mSv. Changes have become effective for instance in the transport regulations, in the regulations for radioactive waste delivery and collection, in the field of health physics, and with regard to activities under outside contract; b) the EURATOM basic standards and the new SI units: Becquerel and Sievert have replaced Curie and Rem; c) a number of ICRP recommendations, events and scientific results, which frequently make radiation protection more plausible, or sometimes even necessary; d) the new DIN standards and BMU regulations, which also are a valuable source of reference for the radiation protection officer. (orig./HP) [de

  11. Albert Einstein for beginners. 12. enl. and rev. ed.

    International Nuclear Information System (INIS)

    Karamanolis, Stratis

    2008-01-01

    He was called the most important jew since the birth of Christus. Others however believed however he has came like no other nearer to the gods. Thought is Albrt Einstein, the scientific work of him and especially his relativity theory has the world changed radically both in scientific and in political regard. The present 12th extended and strongly revised edition of the book, which came out firstly above 20 years ago and until today thousands of readers - young and old - has always enthused, describes not only the relativity theory but also the role, which Einstein played in the development of the first atomic bomb. A short biographical part mediates to the reader also something about the man Einstein

  12. LabVIEW 8 student edition

    CERN Document Server

    Bishop, Robert H

    2007-01-01

    For courses in Measurement and Instrumentation, Electrical Engineering lab, and Physics and Chemistry lab. This revised printing has been updated to include new LabVIEW 8.2 Student Edition. National Instruments' LabVIEW is the defacto industry standard for test, measurement, and automation software solutions. With the Student Edition of LabVIEW, students can design graphical programming solutions to their classroom problems and laboratory experiments with software that delivers the graphical programming capabilites of the LabVIEW professional version. . The Student Edition is also compatible with all National Instruments data acquisition and instrument control hardware. Note: The LabVIEW Student Edition is available to students, faculty, and staff for personal educational use only. It is not intended for research, institutional, or commercial use. For more information about these licensing options, please visit the National Instruments website at (http:www.ni.com/academic/)

  13. Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function

    DEFF Research Database (Denmark)

    Bugge, Anne Skovsø; Feng, Dan; Everett, Logan J

    2012-01-01

    of binding sites across the genome, enriched near metabolic genes. Depletion of both Rev-erbs in liver synergistically derepresses several metabolic genes as well as genes that control the positive limb of the molecular clock. Moreover, deficiency of both Rev-erbs causes marked hepatic steatosis, in contrast......-autonomous clock as well as hepatic lipid metabolism. Mouse embryonic fibroblasts were rendered arrhythmic by depletion of both Rev-erbs. In mouse livers, Rev-erbβ mRNA and protein levels oscillate with a diurnal pattern similar to that of Rev-erbα, and both Rev-erbs are recruited to a remarkably similar set...

  14. Radiotherapy and radiooncology: An interdisciplinary approach. 4. tot. new rev. and enl. ed.; Strahlentherapie und Radioonkologie aus interdisziplinaerer Sicht

    Energy Technology Data Exchange (ETDEWEB)

    Karstens, J.H.; Bremer, M.; Meyer, A.; Warszawski, A.; Bruns, F. (eds.) [Medizinische Hochschule Hannover (Germany). Abt. fuer Strahlentherapie und Spezielle Onkologie

    2005-07-01

    This is the 4th, completely revised edition of the successful book on modern cancer therapy. The focus of this edition is on interdisciplinary cooperation. Current knowledge, both legal and medical, is presented in a clear and well-structured form. The text is supplemented by many illustrative drawings and pictures. The book addresses students and other readers interested in oncology and provides useful and detailed information on radiation therapy of benign and malignant diseases. (orig.)

  15. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 99 Revision 1 (FGE.99Rev1): Consideration of furanone derivatives evaluated by the JECFA (63rd, 65th and 69th meetings)

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    on metabolism and toxicity. The present consideration concerns a group of six furanone derivatives evaluated by the JECFA at their 63rd, 65th and 69th meetings. This revision of FGE.99 includes the assessment of the 2,5-dimethyl-4-methoxyfuran-3(2H)-one [FL-no: 13.089] cleared for genotoxicity concern compared...

  16. EFSA CEF Panel (EFSA Panel on Fo od Contact Materials, Enzymes, Flavourings and Proce ssing Aids), 2015. Scientific Opinion on Flavouring Group Evalua tion 09, Revision 6 (FGE.09Rev6): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 22 flavouring substances in the Flavouring Group Evaluation 9, Revision 6, using the Procedure in Commission Regulation (EC) No 1565/2000. None of the subs...

  17. EFSA Panel on F ood Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) ; Scientific Opinion on Flavouring Group Evaluation 63, Revision 2 (FGE.63Rev2): Consideration of aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59 th and 6 9 th meeting s

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 20 aliphatic secondary alcohols, ketones and related esters evaluated by the JECFA at the 59th and 69th meetings in 2002 and 2008. This revision is made due to inclusion of one...

  18. EFSA ; Scientific Opinion on Flavouring Group Evaluation 63, Revision 1 (FGE.63Rev1): Consideration of aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th and 69th meetings) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 19 aliphatic secondary alcohols, ketones and related esters evaluated by the JECFA at the 59th and 69th meetings in 2002 and 2008. This revision is made due to inclusion of six...

  19. EFSA CEF Penal (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 212, Revision 2 (FGE.212Rev2): α,β-Unsaturated alicyclic ketones and precursors from chemical subgroup 2.6 of FGE.19

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Lund, Pia

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 24 flavouring substances from subgroup 2.6 of FGE.19 in the Flavouring Group Evaluation 212, Revision 2. The Panel concluded in ...

  20. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 9, Revision 3 (FGE.09Rev3): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 17 flavouring substances in the Flavouring Group Evaluation 9, Revision 3, using the Procedure in Commission Regulation (EC) No 1565/2000. None of the subs...

  1. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 9, Revision 4 (FGE.09Rev4): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 21 flavouring substances in the Flavouring Group Evaluation 9, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. The present revi...

  2. EFSA Scientific Opinion on Flavouring Group Evaluation 87 Revision 1 (FGE.87Rev1): Consideration of bicyclic secondary alcohols, ketones and related esters evaluated by JECFA (63rd meeting) structurally related to bicyclic secondary alcohols, ketones and related esters evaluated by EFSA in FGE.47

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 17 bicyclic secondary alcohols, ketones and related esters evaluated by the JECFA at the 63rd meeting in 2004. This revision of FGE.87 is made due to consideration of two additional...

  3. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 7, Revision 4 (FGE.07Rev4): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 49 flavouring substances in the Flavouring Group Evaluation 07, including additional five substances in this Revision 4, using the Procedure in Commission ...

  4. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 9, Revision 5 (FGE.09Rev5): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Frandsen, Henrik Lauritz; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 21 flavouring substances in the Flavouring Group Evaluation 9, Revision 5, using the Procedure in Commission Regulation (EC) No 1565/2000. The present revi...

  5. EFSA Panel on Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 51, Revision 1: Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by the JECFA (59th meeting) structurally related to alicyclic, ketones secondary alcohols and related esters in FGE.09Rev3 (2011)

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 20 alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting) in 2002. This revision is made due to inclusion of seven additional substances...

  6. EFSA ; Scientific Opinion on Flavouring Group Evaluation 94, Revision 1 (FGE.94Rev1): Consideration of aliphatic amines and amides evaluated in an addendum to the group of aliphatic and aromatic amines and amides evaluated by the JECFA (68th meeting)

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 12 aliphatic amines and amides evaluated by the JECFA at the 68th meeting in 2007. This revision of the consideration is made due to additional toxicity data available for two...

  7. LLNL Radiation Protection Program (RPP) Rev 9.2, Implementation of 10 CFR 835, 'Occupational Radiation Protection'

    Energy Technology Data Exchange (ETDEWEB)

    Shingleton, K. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-06-15

    The Department of Energy (DOE) originally issued Part 10 CFR 835, Occupational Radiation Protection, on January 1, 1994. This regulation, hereafter referred to as “the Rule”, required DOE contractors to develop and maintain a DOE-approved Radiation Protection Program (RPP); DOE approved the initial Lawrence Livermore National Laboratory (LLNL) RPP (Rev 2) on 6/29/95. DOE issued a revision to the Rule on December 4, 1998 and approved LLNL’s revised RPP (Rev 7.1) on 11/18/99. DOE issued a second Rule revision on June 8, 2007 (effective July 9, 2007) and on June 13, 2008 approved LLNL’s RPP (Rev 9.0) which contained plans and measures for coming into compliance with the 2007 Rule changes. DOE issued a correction to the Rule on April 21, 2009.

  8. SSC-K code users manual (rev.1)

    International Nuclear Information System (INIS)

    Kwon, Y. M.; Lee, Y. B.; Chang, W. P.; Hahn, D.

    2002-01-01

    The Supper System Code of KAERI (SSC-K) is a best-estimate system code for analyzing a variety of off-normal or accidents in the heat transport system of a pool type LMR design. It is being developed at Korea Atomic Energy Research Institution (KAERI) on the basis of SSC-L, originally developed at BNL to analyze loop-type LMR transients. SSC-K can handle both designs of loop and pool type LMRs. SSC-K contains detailed mechanistic models of transient thermal, hydraulic, neutronic, and mechanical phenomena to describe the response of the reactor core, coolant, fuel elements, and structures to accident conditions. This report provides a revised User's Manual (rev.1) of the SSC-K computer code, focusing on phenomenological model descriptions for new thermal, hydraulic, neutronic, and mechanical modules. A comprehensive description of the models for pool-type reactor is given in Chapters 2 and 3; the steady-state plant characterization, prior to the initiation of transient is described in Chapter 2 and their transient counterparts are discussed in Chapter 3. Discussions on the intermediate heat exchanger (IHX) and the electromagnetic (EM) pump are described in Chapter 4 and 5, respectively. A model of passive safety decay heat removal system (PSDRS) is discussed in Chapter 6, and models for various reactivity feedback effects are discussed in Chapter 7. In Chapter 8, constitutive laws and correlations required to execute the SSC-K are described. New models developed for SSC-K rev.1 are two dimensional hot pool model in Chapter 9, and long term cooling model in Chapter 10. Finally, a brief description of MINET code adopted to simulate BOP is presented in Chapter 11. Based on test runs for typical LMFBR accident analyses, it was found that the present version of SSC-K would be used for the safety analysis of KALIMER. However, the further validation of SSC-K is required for real applications. It is noted that the user's manual of SSC-K will be revised later with the

  9. Introducing RevPASH: The Free Webtool Application

    Directory of Open Access Journals (Sweden)

    Peter Szende

    2014-10-01

    Full Text Available RevPASH (Revenue Per Available Seat Hour is an important measure that helps restaurant operators understand how efficiently each seat in a restaurant generates revenue. The RevPASH app is an easy-to-use web-tool that provides an operator with a quick way to input a few relevant numbers and calculate RevPASH.The application has the ability to compare RevPASH over different times, days, weeks, and months.

  10. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 73, Revision 3 (FGE.73Rev3): Consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th and 63rd meeting

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Frandsen, Henrik Lauritz; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... of one additional substance, beta-ionyl acetate [FL-no: 09.305] cleared for genotoxicity concern in FGE.213Rev1. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern.......712] considered in this FGE and agrees with the JECFA conclusion, “No safety concern at estimated levels of intake as flavouring substances” based on the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered...

  11. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 3, Revision 2 (FGE.03Rev2): Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated or unsaturated

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate one flavouring substance, acetaldehyde ethyl isopropyl acetal [FL-no: 06.137], structurally related to the 58 flavouring substances in the Flavouring Group...... on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded as for the other already evaluated substances that the substance [FL-no: 06.137] do not give rise to safety concern at its level of dietary...... intake, estimated on the basis of the MSDI approach. Besides the safety assessment of this flavouring substance, the specifications for the materials of commerce have also been considered, and since the publication of FGE.03Rev1 additional information on chirality on 30 substances is made available...

  12. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 18, Revision 2 (FGE.18Rev2): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 32 flavouring substances in the Flavouring Group Evaluation 18, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. None of the sub......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 32 flavouring substances in the Flavouring Group Evaluation 18, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. None...... of the substances were considered to have genotoxic potential. The substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity......, the specifications for the materials of commerce have also been considered and for six substances information is lacking....

  13. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 08, Revision 5 (FGE.08Rev5): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since the publi......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since...... approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that 59 substances do not give rise to safety concerns at their levels of dietary intake, estimated...... substances, the specifications for the materials of commerce have also been considered and for three substances, evaluated through the Procedure, information on the specifications is lacking....

  14. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 70 flavouring substances in the Flavouring Group Evaluation 08, Revision 3, using the Procedure in Commission Regulation (EC) No 1565/2000. For the substan......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 70 flavouring substances in the Flavouring Group Evaluation 08, Revision 3, using the Procedure in Commission Regulation (EC) No 1565......-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that 48 substances do not give rise to safety concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. For the remaining fourteen......, the specifications for the materials of commerce have also been considered and for eightteen substances information on specifications is lacking....

  15. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13 Rev2) Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 27 flavouring substances in the Flavouring Group Evaluation 13, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. Three...... of commerce have also been considered. Adequate specifications including complete purity criteria and identity for the materials of commerce have been provided for all 24 flavouring substances evaluated through the Procedure....

  16. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 21, Revision 2 (FGE.21Rev2): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 56 flavouring substances in the Flavouring Group Evaluation 21, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. Seven...... of commerce have also been considered. For two substances are an identity test lacking and for one has the stereoisomeric composition to be specified....

  17. Administrative Cicular No. 31 (Rev. 2) - International indemnity and non-resident allowance

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 31 (Rev. 2) entitled "International indemnity and non-resident allowance", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 23 June 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208547.   This revised circular cancels and replaces Administrative Circular No. 31 (Rev. 1) also entitled "International indemnity and non-resident allowance" of October 2007. The main changes reflect the decision taken in the framework of the five-yearly review to extend eligibility for international indemnity to all staff members, as well to introduce a distinction between current staff members and those recruited as from 1st September 2016. For the latter, the international indemnity will be calculated as a percentage of the minimum salary of the grade into which they are recruited; the amount granted to the former will not change, and is now expressed ...

  18. Administrative Circular No. 11 (Rev. 3) - Categories of members of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 11 (Rev. 3) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 3 July 2014 and entering into force on 1 September 2014, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel” of January 2013. The circular was revised in order to include a minor adjustment of the determination of required period of break in the payment of subsistence allowance to certain categories of associated members of the personnel (taking account of possible technical means of control). Furthermore, the possibility of traineeships of long duration was restricted to cases in which the traineeship is awarded pursuant to an agreement between CERN and a...

  19. Administrative Circular No. 13 (Rev. 3) - Guarantees for representatives of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 13 (Rev. 3) entitled “Guarantees for representatives of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 13 (Rev. 2) entitled “Guarantees for members of the personnel holding representative office” of November 1992. The circular was revised in order to adapt the time given to the representatives of the personnel to perform their elective mandate and to ensure more transparency in their activities, by indicating, inter alia, the percentage of time worked in the framework of their mandate, as well as the training, activities and ensuing results. Department Head Office HR Department

  20. Administrative circular n°23 (Rev. 3) – Special working hours

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 23 (Rev. 3) entitled “Special working hours”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to staff members and fellows. It cancels and replaces Administrative Circular No. 23 (Rev. 2) entitled “Special working hours” of December 2008. Paragraph 6 a) of Annex II of this circular was revised following the modification of Article III 1.04 of the Staff Regulations approved by Council on 14 December 2012. The modification serves to adapt the minimum rest time to the fact that, in case of rapidly alternating shifts, a maximum of seven consecutive shifts may be performed. Department Head Office HR Department

  1. Rev 12 as a theology of history

    OpenAIRE

    Joanna Nowińska

    2009-01-01

    The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger), places (the temple, a desert), persons (the Child-Ruler, Michael) with the Old T...

  2. Marine botany. Second edition

    International Nuclear Information System (INIS)

    Dawes, C.J.

    1998-01-01

    Marine plants are a diverse group that include unicellular algae, seaweeds, seagrasses, salt marshes, and mangrove forests. They carry out a variety of ecological functions and serve as the primary producers in coastal wetlands and oceanic waters. The theme that connects such a wide variety of plants is their ecology, which was also emphasized in the 1981 edition. The goal of this revision is to present taxonomic, physiological, chemical, and ecological aspects of marine plants, their adaptations, and how abiotic and biotic factors interact in their communities. The data are presented in a concise, comparative manner in order to identify similarities and differences between communities such as salt marsh and mangroves or subtidal seaweeds and seagrasses. To accomplish this, the text is organized into five chapters that introduce the marine habitats, consider abiotic and biotic factors, and anthropogenic influences on the communities followed by seven chapters that deal with microalgae, seaweeds, salt marshes, mangroves, seagrasses, and coral reefs. Two appendixes are included; one presents simple field techniques and the other is a summary of seaweed uses

  3. Imaging pelvic floor disorders. 2. rev. ed.

    International Nuclear Information System (INIS)

    Stoker, Jaap; Taylor, Stuart A.; DeLancey, John O.L.

    2008-01-01

    This volume builds on the success of the first edition of imaging pelvic floor disorders and is aimed at those practitioners with an interest in the imaging, diagnosis and treatment of pelvic floor dysfunction. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving field. Introductory chapters fully elucidate the anatomical basis underlying disorders of the pelvic floor. State of the art imaging techniques and their application in pelvic floor dysfunction are then discussed in detail. Additions since the first edition include consideration of the effect of aging and new chapters on perineal ultrasound, functional MRI and MRI of the levator muscles. The closing sections of the book describe the modern clinical management of pelvic floor dysfunction, including prolapse, urinary and faecal incontinence and constipation, with specific emphasis on the integration of diagnostic and treatment algorithms. (orig.)

  4. Imaging pelvic floor disorders. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Stoker, Jaap [Amsterdam Univ. (Netherlands). Dept. of Radiology; Taylor, Stuart A. [University College Hospital, London (United Kingdom). Dept. of Specialist X-Ray; DeLancey, John O.L. (eds.) [Michigan Univ., Ann Arbor, MI (United States). L4000 Women' s Hospital

    2008-07-01

    This volume builds on the success of the first edition of imaging pelvic floor disorders and is aimed at those practitioners with an interest in the imaging, diagnosis and treatment of pelvic floor dysfunction. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving field. Introductory chapters fully elucidate the anatomical basis underlying disorders of the pelvic floor. State of the art imaging techniques and their application in pelvic floor dysfunction are then discussed in detail. Additions since the first edition include consideration of the effect of aging and new chapters on perineal ultrasound, functional MRI and MRI of the levator muscles. The closing sections of the book describe the modern clinical management of pelvic floor dysfunction, including prolapse, urinary and faecal incontinence and constipation, with specific emphasis on the integration of diagnostic and treatment algorithms. (orig.)

  5. Administrative Circular No. 30 (Rev. 3) - “Financial benefits on taking up appointment and on termination of contract”

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 30 (Rev. 3) entitled “Financial benefits on taking up appointment and on termination of contract”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, is available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 30 (Rev. 3) is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 30 (Rev. 2/Corr.) entitled "Financial benefits on taking up appointment and on termination of contract” of September 2009. This circular was revised in order to implement the modifications introduced into the Staff Rules and Regulations in January 2013 relating to the introduction of the status of Associate Member States and new categories of associated members of the personnel. In particular, the notion of “Member State” in Annexe II (&a...

  6. Revised legislation affecting the transport of radioactive materials

    International Nuclear Information System (INIS)

    Rowlands, R.P.

    1976-01-01

    The revised edition of the model Regulations for the safe transport of radioactive materials (1973, Vienna, International Atomic Energy Agency Safety Series no.6) has acted as the basis for the conditions of carriage and regulatory requirements in Great Britain. The changes introduced in this revised edition are discussed, and the current Regulations and Codes of Practice covering U.K. and international transport by road, sea, rail and air reviewed. (U.K.)

  7. Rev 12 as a theology of history

    Directory of Open Access Journals (Sweden)

    Joanna Nowińska

    2009-12-01

    Full Text Available The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger, places (the temple, a desert, persons (the Child-Ruler, Michael with the Old Testament figurative exposing, a typical one for such a book (the Woman with Child, the heaven, the dragon, enriched with a lot of symbols (a crown, a horn, the moon under feet. God’s interference into World history is presented through lightning, voices, thunder, an earthquake and great hail, that stress His power and supremacy. The biblical writer refers to events, which make place whole the time in the natural- and supernatural space, like: the war between God and evil, persecutions, hiding, God’s care of men.  The specific literary structure of Rev 12, contrary to the other parts of that book, seem to help to put an accent for the fundamental truths for transcendental theology of history of which the most important is the eternal rule of God and only accidental, finished in the time perspective of Satan’s position.

  8. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 20, Revision 3 (FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider in this revision 3 of Flavouring Group Evaluation 20, the SCF Opinion on benzoic acid. Furthermore information on stereoisomeric composition for two...... Regulation (EC) No 1565/2000. None of the substances were considered to have genotoxic potential. The substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern...

  9. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 23, Revision 3 (FGE.23Rev3): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 20 flavouring substances in the Flavouring Group Evaluation 23, Revision 3, using the Procedure in Commission Regulation (EC) No 1565/2000. None...... of the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered. Specifications including complete purity criteria and identity for the materials of commerce have been provided for all 20 candidate substances....

  10. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 30, Revision 1 (FGE.30Rev1): 4-Prop-1-enylphenol and 2-methoxy-4-(prop- 1enyl)phenyl 3-methylbutyrate from chemical group 17

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate two flavouring substances in the Flavouring Group Evaluation 30, Revision 1, using the Procedure in Commission Regulation (EC) No 1565/2000. None of the su......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate two flavouring substances in the Flavouring Group Evaluation 30, Revision 1, using the Procedure in Commission Regulation (EC) No 1565/2000. None...... of the substances were considered to have genotoxic potential. The two substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel...... concluded that the two substances [FL-no: 04.097, 09.894] do not give rise to safety concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been...

  11. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since the publi......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since...... be estimated and accordingly the Panel concluded that the Procedure could not be applied to these four substances either. The remaining 71 substances were evaluated through a stepwise approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold.......116, 12.120, 12.164, 12.167, 12.199, 15.007, 15.102 and 15.125 and 15.134], evaluated through the Procedure, no appropriate NOAEL was available and additional data are required. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also been...

  12. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 06, Revision 3 (FGE.06Rev3): Straight- and branched-chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters from chemical groups 1

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 50 flavouring substances in the Flavouring Group Evaluation 6, Revision 3, using the Procedure in Commission Regulation (EC) No 1565/2000. None of the subs......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 50 flavouring substances in the Flavouring Group Evaluation 6, Revision 3, using the Procedure in Commission Regulation (EC) No 1565/2000. None...... of the substances were considered to have genotoxic potential. The substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity...... of these flavouring substances, the specifications for the materials of commerce have also been considered. For one substance [FL-no: 09.938] an identity test is missing and for two substances [FL-no: 05.226 and 09.950] the range of the specific gravity is too wide. Additional, the stereoisomeric mixture has not been...

  13. Suppression of atherosclerosis by synthetic REV-ERB agonist

    Energy Technology Data Exchange (ETDEWEB)

    Sitaula, Sadichha [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Billon, Cyrielle [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States); Kamenecka, Theodore M.; Solt, Laura A. [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Burris, Thomas P., E-mail: burristp@slu.edu [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States)

    2015-05-08

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.

  14. Operational Circular No. 2 (Rev. 3) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    HR Department

    2015-01-01

    Operational Circular No. 2 (Rev. 3) entitled "Conditions of access to the fenced parts of the CERN site", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 24 September 2015, is now available via this link.   This revised circular cancels and replaces Operational Circular No. 2 (Rev. 2) also entitled "Conditions of access to the fenced parts of the CERN site", of September 2014. The circular was revised predominantly in order to specify that access to the CERN site is granted to CERN Pension Fund beneficiaries only provided that they are actually in receipt of payments from the Fund; and to allow the Director-General to permit special types of vehicles on site, such as trailers. It also includes a certain number of text improvements and an updated version of the implementation measures, in particular with regard to vehicle identification, road traffic and parking.  

  15. ENDF/B-5 Actinides (Rev. 86)

    International Nuclear Information System (INIS)

    Lemmel, H.D.

    1986-05-01

    This document summarizes the contents of the Actinides part of the ENDF/B-5 nuclear data library released by the US National Nuclear Data Center. This library or selective retrievals of it, are available costfree from the IAEA Nuclear Data Section upon request. The present version of the library is the Revision of 1986. (author). Refs, figs and tabs

  16. Multiplex editing system

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a multiplex editing system. The system allows multiple editing of nucleic acid sequences such as genomic sequences, such as knockins of genes of interest in a genome, knockouts of genomic sequences and/or allele replacement. Also provided herein are a method...... for editing nucleic acids and a cell comprising a stably integrated endonuclease....

  17. Revising Translations

    DEFF Research Database (Denmark)

    Rasmussen, Kirsten Wølch; Schjoldager, Anne

    2011-01-01

    The paper explains the theoretical background and findings of an empirical study of revision policies, using Denmark as a case in point. After an overview of important definitions, types and parameters, the paper explains the methods and data gathered from a questionnaire survey and an interview...... survey. Results clearly show that most translation companies regard both unilingual and comparative revisions as essential components of professional quality assurance. Data indicate that revision is rarely fully comparative, as the preferred procedure seems to be a unilingual revision followed by a more...... or less comparative rereading. Though questionnaire data seem to indicate that translation companies use linguistic correctness and presentation as the only revision parameters, interview data reveal that textual and communicative aspects are also considered. Generally speaking, revision is not carried...

  18. Radiological imaging of the neonatal chest. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Donoghue, Veronica (ed.) [Children' s University Hospital, Dublin (Ireland). Dept. of Radiology; National Maternity Hospital, Dublin (Ireland)

    2008-07-01

    This second, revised edition of Radiological Imaging of the Neonatal Chest provides a comprehensive and up-to-date discussion of the subject. It is written primarily from the point of view of the paediatric radiologist but will be of particular interest to all antenatal ultrasonographers, neonatologists, paediatric cardiologists, paediatricians and paediatric surgeons. It includes an update on clinical management and appraises the advantages of the various techniques available to image the newborn chest. There is particular emphasis on the impact of recent therapeutic advances on imaging findings. Extensive consideration is given to both antenatal and postnatal imaging of congenital chest malformations, as well as to controversies regarding the postnatal management of asymptomatic infants with these anomalies. There are dedicated chapters on upper airway problems, infection and congenital heart disease, with special emphasis on the current role of magnetic resonance imaging, computed tomography and interventional therapy. There is also a chapter devoted to computed radiography and digital radiography. This book contains important information for all those involved in caring for the neonate. (orig.)

  19. Bones - joints - soft tissues II. 7. rev. ed.

    International Nuclear Information System (INIS)

    Dihlmann, W.; Frommhold, W.

    1991-01-01

    With the publication of the 2nd part to Volume VI, 'Bones - joints - soft tissues', the 7th edition of 'Diagnostic radiology in the hospital and medical practice' is complete. The advances made particularly during the past decade in the field of diagnostic radiology have made it neccesary for all the individual sections to be completely revised. Recently developed methods of imaging like sonography, computed tomography and magnetic resonance tomography are increasingly used as a replacement for or, at least, an adjunct to conventional X-ray procedures. Owing to the development and continuous refinement of related methods of intervention the gap between mere diagnostic applications and therapeutic uses of radiology could eventually be closed. The issues mainly discussed in this volume are bone fractures and healing, bone transplantation, osteopathy and osteoarthropathy, fibrous dyplasia or Albright's disease, Pagetoid osteitis, genetically transmitted constitutional disorders of the skeleton and soft tissue changes. While in the key sections on bone fractures and healing, osteopathy and osteoarthropathy as well as constitutional genetic disorders X-ray techniques are still described as the prevailing method of diagnosis, diseases of soft tissues now are much more commonly diagnosed using magnetic resonance imaging. (orig./MG) With 2248 figs., 59 tabs [de

  20. Arrangements for transition from the 1985 edition (as amended 1990) to the 1996 edition of the IAEA Transport Regulations

    International Nuclear Information System (INIS)

    2001-03-01

    The purpose of this publication is to provide guidance to National Competent Authorities to facilitate compliance during, and after, transition from the previous edition of the International Atomic Energy Agency's (IAEA's) Transport Regulations (Safety Series No. 6, 1985 Edition, as Amended 1990) to the 1996 editions (TS-R-1 [ST-1, Revised], in English; ST-1 in French, Russian and Spanish) of the regulations. This may also provide guidance to other users of the IAEA's Transport Regulations such as consignors, carriers, consignees, owners and designers and fabricators of radioactive material and package designers and fabrications

  1. Editörden

    Directory of Open Access Journals (Sweden)

    Nadir Arıcan

    2007-04-01

    Full Text Available Değerli Adli Bilimci’ler, Dergimizin ilk baskısının yapıldığı 1996 yılından 2006 yılı sonuna kadar 11 ciltten oluşan dizisini ara vermeden kesintisiz olarak yayınlanma başarısını gösteren Adli Tıp Bülteni Yayın Kurulu adına saygı ile selamlıyoruz. Dergimizin 12. cildinin ilk sayısı, yayın kurulundaki görev değişikliği ile elinize ulaşıyor. “Adli Tıp Bülteni”ni tüm olumsuz koşullara karşın, siz alana emek veren adli bilimcilerin de büyük desteği ile yayın hayatım başarı ile sürdürdü. Bu başarıda başta editörlerimiz sayın Prof. Dr. Serpil Salaçin ve sayın Prof. Dr. Şebnem Korur Fincancı ile yayın kurulunda görev almış meslektaşlarımıza teşekkür ediyor ve desteklerinin artarak devam edeceğini ümit ediyoruz. Adli Tıp Bülteni, ilk editörü sayın Prof. Dr. Serpil Salaçin’in bültenin 1. sayısında belirttiği amaca uygun olarak, her geçen gün daha da güçlenerek yayın hayatını sürdürmektedir. Yayın akışında zaman zaman kesintiler olsa da, amacı doğrultusunda “alanındaki bilgi akışını sağlama ve bilimsel gelişmelerin önemli bir parçası olma özelliğini” Adli Tıp Uzmanları Derneği’nin resmi bilimsel yayın organı kimliği ile devam ettirmektedir. Hedefleri doğrultusunda uluslararası indekslerce taranan bir dergi olma yolunda ilk adımını atan dergimizin bu alandaki çalışmaları sayın Prof. Dr. Şebnem Korur Fincancı tarafından yürütülmektedir. Görevini genç meslektaşına devretmiş olsa da alanımızdaki uluslar arası deneyimi ile Adli Tıp Bülteni’ni çok farklı noktalara taşıyacağı inancındayım. Bu alanda yapacağı katkılardan dolayı sayın hocama biz kez daha teşekkür etmek istiyorum. Bundan böyle Adli Tıp Bülteni’ne yayınlanmak üzere gönderdiğiniz çalışmalarınızın değerlendirmesini daha hızlı yapabilmek ve baskı aşamasına getirmek amacı ile iletişimi elektronik ortamda yapmaya

  2. Malaria control in humanitarian emergencies: An interagency field handbook, 2nd Edition

    OpenAIRE

    Howard, N; Clements-Hunt, A

    2013-01-01

    This second edition represents a thorough updating and revision of the first edition. The structure remains similar, but includes an additional chapter on humanitarian coordination. All chapters have been revised to reflect changes in best practices, improvements in technologies, availability of new tools, and changes in WHO recommendations. The interagency handbook was developed to set out effective malaria control responses in humanitarian emergencies, particularly during the acute phase wh...

  3. New Directions in Reading Instruction--Revised.

    Science.gov (United States)

    Hinson, Bess, Ed.

    The gains in knowledge about the nature of reading and how to most effectively teach it come from cognitive research. This booklet (in the form of a flipchart) synthesizes and summarizes much of the current research on effective instruction for improved literacy and greater student achievement. The booklet, a revised edition of "New…

  4. Cloud Properties of CERES-MODIS Edition 4 and CERES-VIIRS Edition 1

    Science.gov (United States)

    Sun-Mack, Sunny; Minnis, Patrick; Chang, Fu-Lung; Hong, Gang; Arduini, Robert; Chen, Yan; Trepte, Qing; Yost, Chris; Smith, Rita; Brown, Ricky; hide

    2015-01-01

    The Clouds and Earth's Radiant Energy System (CERES) analyzes MODerate-resolution Imaging Spectroradiometer (MODIS) data and Visible Infrared Imaging Radiometer Suite (VIIRS) to derive cloud properties that are combine with aerosol and CERES broadband flux data to create a multi-parameter data set for climate study. CERES has produced over 15 years of data from Terra and over 13 years of data from Aqua using the CERES-MODIS Edition-2 cloud retrieval algorithm. A recently revised algorithm, CERESMODIS Edition 4, has been developed and is now generating enhanced cloud data for climate research (over 10 years for Terra and 8 years for Aqua). New multispectral retrievals of properties are included along with a multilayer cloud retrieval system. Cloud microphysical properties are reported at 3 wavelengths, 0.65, 1.24, and 2.1 microns to enable better estimates of the vertical profiles of cloud water contents. Cloud properties over snow are retrieved using the 1.24-micron channel. A new CERES-VIIRS cloud retrieval package was developed for the VIIRS spectral complement and is currently producing the CERES-VIIRS Edition 1 cloud dataset. The results from CERES-MODIS Edition 4 and CERES-VIIRS Edition 1 are presented and compared with each other and other datasets, including CALIPSO, CloudSat and the CERES-MODIS Edition-2 results.

  5. Radiology of the pancreas. 2. rev. ed.

    International Nuclear Information System (INIS)

    Baert, A.L.; Van Hoe, L.; Delorme, G.

    1999-01-01

    Radiology of the Pancreas discusses the diagnostic role of the various imaging modalities currently available for the assessment of pancreatic anatomy and disease. In comparison with the first edition, new technical developments (helical CT, ultrafast magnetic resonance imaging, color Doppler ultrasound, laparoscopic ultrasound), have been included, and several chapters have been significantly expanded. With the aid of numerous illustrations, the normal radiological anatomy, anatomical variants, the typical and atypical radiological features of both common and uncommon diseases, and potential pitfalls are considered in depth. All of the chapters have been written by recognized experts in the field, and the book should be of value to all radiologists and other specialists who treat patients with pancreatic disease or who have an interest in the subject. (orig.)

  6. Administrative Circular No. 14 (Rev. 2)

    CERN Document Server

    HR Department

    2007-01-01

    The HR Department wishes to draw the attention of members of the personnel to a number of amendments to Administrative Circular No. 14 (Rev. 2) entitled "Protection of members of the personnel against the financial consequences of illness, accident and disability" which came into force on 1st July 2006 (cf. Weekly Bulletin of 14 and 21 August 2006). Occupational Accident Declaration Form (HS50) https://cern.ch/service-procedures/AdminMan/Forms/HS50E.doc •\tIt must be completed within 10 working days of the date on which the accident occurred (§ 29.2.1), unless the person concerned is materially unable to meet this deadline. • The completed formula must be accompanied by a medical certificate giving details of any bodily injuries resulting from the accident (Annex 1, § 5). The medical certificate must be obtained from the doctor who has been consulted for that purpose. Benefits resulting from illnesses and accidents Medical treatment will cease to be reimbursed under ...

  7. Revised Huang-Yang multipolar pseudopotential

    International Nuclear Information System (INIS)

    Derevianko, Andrei

    2005-01-01

    A number of authors have recently pointed out inconsistencies of results obtained with the Huang-Yang multipolar pseudopotential for low-energy scattering [K. Huang and K. C. Yang, Phys. Rev. 105, 767 (1957); later revised by Huang, Statistical Mechanics (Wiley, New York, 1963)]. The conceptual validity of their original derivation has been questioned. Here I show that these inconsistencies are rather due to an algebraic mistake made by Huang and Yang. With the corrected error, I present the revised version of the multipolar pseudopotential

  8. New Mandates and Imperatives in the Revised "ACA Code of Ethics"

    Science.gov (United States)

    Kaplan, David M.; Kocet, Michael M.; Cottone, R. Rocco; Glosoff, Harriet L.; Miranti, Judith G.; Moll, E. Christine; Bloom, John W.; Bringaze, Tammy B.; Herlihy, Barbara; Lee, Courtland C.; Tarvydas, Vilia M.

    2009-01-01

    The first major revision of the "ACA Code of Ethics" in a decade occurred in late 2005, with the updated edition containing important new mandates and imperatives. This article provides interviews with members of the Ethics Revision Task Force that flesh out seminal changes in the revised "ACA Code of Ethics" in the areas of confidentiality,…

  9. General edition program

    International Nuclear Information System (INIS)

    Vaturi, Sylvain

    1969-01-01

    Computerized edition is essential for data processing exploitation. When a more or less complex edition program is required for each task, then the need for a general edition program become obvious. The aim of this study is to create a general edition program. Universal programs are capable to execute numerous and varied tasks. For a more precise processing, the execution of which is frequently required, the use of a specialized program is preferable because, contradictory to the universal program, it goes straight to the point [fr

  10. Radioactivity: Risks - safety. 2. rev. ed.

    International Nuclear Information System (INIS)

    Grupe, H.

    1991-01-01

    This revised and updated version of the report first published in 1987 by Karlsruhe Nuclear Center has been prepared by scientists of the Center who are experts in nuclear science and technology. The idea was to fulfill the so-to-speak ''creditor's'' obligation in the public debate about nuclear energy and its hazards, and to provide the general public not so familiar with the subject matter with information and insight for better understanding, hoping that the general public on their part will fulfill their ''debtor's'' obligation by trying to get properly informed. Chapters 1 and 6 of the report have been revised and brought up to date, while chapter 3 has been fully re-written, taking as a main source of reference the 1989 publication of Phase B of the German Risk Study on nuclear power plant. Chapters 2 and 5 are new in this report, dealing with less broadly known applications of radioactive substances in science, medicine and technology, and with the radiological situation in Germany after the Chernobyl reactor accident. (orig./DG) [de

  11. Revised SRAC code system

    International Nuclear Information System (INIS)

    Tsuchihashi, Keichiro; Ishiguro, Yukio; Kaneko, Kunio; Ido, Masaru.

    1986-09-01

    Since the publication of JAERI-1285 in 1983 for the preliminary version of the SRAC code system, a number of additions and modifications to the functions have been made to establish an overall neutronics code system. Major points are (1) addition of JENDL-2 version of data library, (2) a direct treatment of doubly heterogeneous effect on resonance absorption, (3) a generalized Dancoff factor, (4) a cell calculation based on the fixed boundary source problem, (5) the corresponding edit required for experimental analysis and reactor design, (6) a perturbation theory calculation for reactivity change, (7) an auxiliary code for core burnup and fuel management, etc. This report is a revision of the users manual which consists of the general description, input data requirements and their explanation, detailed information on usage, mathematics, contents of libraries and sample I/O. (author)

  12. Introduction into thermodynamics. From elements to technical applications. 13. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Cerbe, G.; Hoffmann, H.J.

    2002-01-01

    This textbook has been proved for more than 30 years and has been regularly revised and updated. Thus, recent developments in energy conversion and environmental protection have constantly been taken into account. Tabulated values and standards reflect the current state of things. The book's basic concept was maintained without change from the first to the twelfth edition: leading over from well-founded thermodynamic theory to technical applications, closeness to practice because of many examples with solutions and tasks with solution results, the opportunity for self-study with 130 examples, 135 tasks and 175 control questions with answers, and high usability because of many tables and direct-information diagrams. The 13th edition was actualised and enhanced by combined-cycle power plants and fuel cells. (orig./GL) [de

  13. 200 area liquid effluent facility quality assurance program plan. Revision 1

    International Nuclear Information System (INIS)

    Sullivan, N.J.

    1995-01-01

    Direct revision of Supporting Document WHC-SD-LEF-QAPP-001, Rev. 0. 200 Area Liquid Effluent Facilities Quality Assurance Program Plan. Incorporates changes to references in tables. Revises test to incorporate WHC-SD-LEF-CSCM-001, Computer Software Configuration Management Plan for 200 East/West Liquid Effluent Facilities

  14. Pediatric Dentistry: A Clinical Approach, 3rd Edition

    DEFF Research Database (Denmark)

    Pediatric Dentistry: A Clinical Approach, Third Edition provides a uniquely clear, comprehensive, and clinical approach to the dental treatment of children and adolescents. •Offers systematic coverage of all clinical, scientific and social topics relating to pediatric dentistry •Thoroughly revised...

  15. Short-Term Play Therapy for Children. Second Edition

    Science.gov (United States)

    Kaduson, Heidi Gerard, Ed.; Schaefer, Charles E., Ed.

    2006-01-01

    Now in a thoroughly revised and updated second edition, this volume presents a variety of play approaches that facilitate children's healing in a shorter time frame. Invaluable for clinicians working within managed care and all those seeking to optimize limited time with clients, the book describes effective methods for individual, family, and…

  16. Adolescent Literacy Resources: An Annotated Bibliography. Second Edition 2009

    Science.gov (United States)

    Center on Instruction, 2009

    2009-01-01

    This annotated bibliography updated from a 2007 edition, is intended as a resource for technical assistance providers as they work with states on adolescent literacy. This revision includes current research and documents of practical use in guiding improvements in grades 4-12 reading instruction in the content areas and in interventions for…

  17. Cognitive-Behavioral Therapy. Second Edition. Theories of Psychotherapy Series

    Science.gov (United States)

    Craske, Michelle G.

    2017-01-01

    In this revised edition of "Cognitive-Behavioral Therapy," Michelle G. Craske discusses the history, theory, and practice of this commonly practiced therapy. Cognitive-behavioral therapy (CBT) originated in the science and theory of classical and instrumental conditioning when cognitive principles were adopted following dissatisfaction…

  18. Information Literacy: Essential Skills for the Information Age, Second Edition

    Science.gov (United States)

    Eisenberg, Michael B.; Lowe, Carrie A.; Spitzer, Kathleen L.

    2004-01-01

    This is the definitive work on information literacy. Michael Eisenberg, known worldwide as one of the originators of the innovative Big6 Information Problem Solving Process, and frequent presenters on the subject Carrie A. Lowe and Kathleen L. Spitzer have extensively revised and updated this long-awaited second edition. Tracing the history of…

  19. Foundations of Bilingual Education and Bilingualism. Sixth Edition

    Science.gov (United States)

    Baker, Colin; Wright, Wayne E.

    2017-01-01

    The sixth edition of this bestselling textbook has been substantially revised and updated to provide a comprehensive introduction to bilingualism and bilingual education in the 21st century. Written in a compact and clear style, the book covers all the crucial issues in bilingualism at individual, group and societal levels. Updates to the new…

  20. Biallelic inactivation of REV7 is associated with Fanconi anemia.

    Science.gov (United States)

    Bluteau, Dominique; Masliah-Planchon, Julien; Clairmont, Connor; Rousseau, Alix; Ceccaldi, Raphael; Dubois d'Enghien, Catherine; Bluteau, Olivier; Cuccuini, Wendy; Gachet, Stéphanie; Peffault de Latour, Régis; Leblanc, Thierry; Socié, Gérard; Baruchel, André; Stoppa-Lyonnet, Dominique; D'Andrea, Alan D; Soulier, Jean

    2016-09-01

    Fanconi anemia (FA) is a recessive genetic disease characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure (BMF), and a strong predisposition to cancer. Twenty FA genes have been identified, and the FANC proteins they encode cooperate in a common pathway that regulates DNA crosslink repair and replication fork stability. We identified a child with severe BMF who harbored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), which encodes the mutant REV7 protein REV7-V85E. Patient-derived cells demonstrated an extended FA phenotype, which included increased chromosome breaks and G2/M accumulation upon exposure to DNA crosslinking agents, γH2AX and 53BP1 foci accumulation, and enhanced p53/p21 activation relative to cells derived from healthy patients. Expression of WT REV7 restored normal cellular and functional phenotypes in the patient's cells, and CRISPR/Cas9 inactivation of REV7 in a non-FA human cell line produced an FA phenotype. Finally, silencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA repair defect underlies the development of BMF in FA. Taken together, our genetic and functional analyses identified REV7 as a previously undescribed FA gene, which we term FANCV.

  1. Analysis of translesion DNA synthesis activity of the human REV1-REV7 complex, which is a key player in radiation-induced mutagenesis

    International Nuclear Information System (INIS)

    Masuda, Y.; Masuda, K.; Kamiya, K.

    2003-01-01

    Full text: Ionizing radiation frequently causes oxidative DNA damage in cells. It has been suggested that functions of the REV1 and REV7 genes are induction of mutations and prevention of cell death caused by ionizing radiation. With yeast Saccharomyces cerevisiae, results from a variety of investigations have demonstrated that the REV genes play a major role in induction of mutations through replication processes which directly copy the damaged DNA template during DNA replication. However, in higher eucaryotes, functions of homologues are poorly understood and appear somewhat different from the yeast case. It has been suggested that human REV1 interacts with human REV7, this being specific to higher eucaryotes. Here we show that purified human REV1 and REV7 proteins form a heterodimer in solution, which is stable through intensive purification steps. Results from biochemical analysis of the transferase reactions of the REV1-REV7 complex demonstrated, in contrast to the case of yeast Rev3 whose polymerase activity is stimulated by assembly with yeast Rev7, that human REV7 did not influence the stability, substrate specificity or kinetic parameters of the transferase reactions of REV1 protein. A possible molecular role of the REV7 subunit may be to help assembly of the REV1 protein to a large complex containing REV3 and/or other DNA polymerases in higher eucaryotes

  2. Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging

    International Nuclear Information System (INIS)

    Wolff, Horst; Hadian, Kamyar; Ziegler, Manja; Weierich, Claudia; Kramer-Hammerle, Susanne; Kleinschmidt, Andrea; Erfle, Volker; Brack-Werner, Ruth

    2006-01-01

    The human immunodeficiency virus Rev protein is a post-transcriptional activator of HIV gene expression. Rev is a nucleocytoplasmic shuttle protein that displays characteristic nuclear/nucleolar subcellular localization in various cell lines. Cytoplasmic localization of Rev occurs under various conditions disrupting Rev function. The goal of this study was to investigate the relationship between localization of Rev and its functional activity in living cells. A triple-fluorescent imaging assay, called AQ-FIND, was established for automatic quantitative evaluation of nucleocytoplasmic distribution of fluorescently tagged proteins. This assay was used to screen 500 rev genes generated by error-prone PCR for Rev mutants with different localization phenotypes. Activities of the Rev mutants were determined with a second quantitative, dual-fluorescent reporter assay. In HeLa cells, the majority of nuclear Rev mutants had activities similar to wild-type Rev. The activities of Rev mutants with abnormal cytoplasmic localization ranged from moderately impaired to nonfunctional. There was no linear correlation between subcellular distribution and levels of Rev activity. In astrocytes, nuclear Rev mutants showed similar impaired activities as the cytoplasmic wild-type Rev. Our data suggest that steady-state subcellular localization is not a primary regulator of Rev activity but may change as a secondary consequence of altered Rev function. The methodologies described here have potential for studying the significance of subcellular localization for functions of other regulatory factors

  3. Coming 5th Edition of the API Standard 618: major changes compared to the API 618, 4th edition

    NARCIS (Netherlands)

    Pyle, A.; Eijk, A.; Elferink, H.

    2003-01-01

    This paper will present the highlights of changes that will be found in the 5th Edition of API 618, which is expected to be published in late 2003 or early 2004. Approximately every 5 years the API Standards are revised in such a way that the latest field experiences and proven designs are included

  4. Wave power plant at Horns Rev. Screening[Denmark]; Boelgekraftanlaeg ved Horns Rev. Screening

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Hans C.; Nielsen, Kim; Steenstrup, P.R.; Friis-Madsen, E.; Wigant, L.

    2005-12-15

    The objective for the analysis has been to establish data for the sea at Horns Rev wind farm in the North Sea in order to assess the opportunity for using the site as test site for demonstration of wave energy devices exemplified by three different devices under development in Denmark. For comparison alternative sites like Hanstholm, Samsoe and Nissum Bredning are also assessed as well as the test centre EMEC at the Orkney Islands and the proposed test site Wave Hub at the north coast of Cornwall. The analysis shows that it is possible without major technical problems to connect 2-4 MW power generated by 3 different wave energy devices (AquaBuOY, Wave Star Energy and Wave Dragon) to the wind farm at Horns Rev (www.hornsrev.dk). The expenses for connection and regulation within the wind farm is about 200,000 DKK (30,00 EURO). On top of this comes the cost for individual sub sea cable connection to the wave devices, pull in of the sub sea cable through the existing J-tube in turbine T04 and the necessary regulation/control system in the individual wave devices to avoid damaging the power system in case of too high production. The analysis of the co-production of wind and wave power is dealt with in a separate report which shows that over a time period of half to one hour the time variation for wind generated electricity is 3 times as large as for wave energy generated power based on the actual measurement at Horns Rev. Further on the analysis shows that the wave generated power is more predictable than wind energy generated power as the power from the waves first is present about 2 hours after the wind is acting and last for 3 to 6 hours after the wind dies out; 6 to 12 hours with wind from west. The time is off course strongly depending of the direction of the wind i.e. the fetch. As this special report has a more general scope than the analysis as such it is reported in English (Annex Report II). The analysis shows that it is up to the individual device developer

  5. Introduction into thermodynamics. From elements to technical applications. 12. rev. ed.

    International Nuclear Information System (INIS)

    Cerbe, G.; Hoffmann, H.J.

    1999-01-01

    This textbook has been proved for more than 30 years and has been regularly revised and updated. Thus, recent developments in energy conversion and environmental protection have constantly been taken into account. Tabulated values and standards reflect the current state of things. The book's basic concept was maintained without change from the first to the twelfth edition: leading over from well-founded thermodynamic theory to technical applications, closeness to practice because of many examples with solutions and tasks with solution results, the opportunity for self-study with 124 examples, 132 tasks and 170 control questions with answers, and high usability because of many tables and direct-information diagrams. (orig.) [de

  6. Differential diagnosis of rheumatic illnesses. 4. compl. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Zeidler, Henning; Michel, Beat

    2009-01-01

    The number of the possible differential diagnosis of rheumatic illnesses is extraordinarily high. This circumstance makes the diagnostics a difficult field with numerous pitfalls. The correct and complete diagnosis however is a condition for the correct therapy. This book facilitates this way from the symptom to the diagnosis for the reader: A detailed representation of the fundamentals (anamnesis, investigation findings, laboratory diagnostics and imaging) a detailed description of all important differential diagnosis follows. The meanwhile fourth edition of this standard work was completely revised and updated. An indispensable guide book for all persons which treat patients with rheumatic illnesses [de

  7. Master Curriculum Guide in Economics. A Framework for Teaching the Basic Concepts. Second Edition.

    Science.gov (United States)

    Saunders, Phillip; And Others

    Intended for curriculum developers, this revised Framework presents a set of basic concepts for teaching K-12 economics. The revision reflects the change and development which the field of economics has undergone and includes improvements suggested by users of the first edition. The purpose of teaching economics is to impart a general…

  8. Quantum invariants of knots and 3-manifolds. 2. rev. ed.

    International Nuclear Information System (INIS)

    Turaev, Vladimir G.

    2010-01-01

    Due to the strong appeal and wide use of this monograph, it is now available in its second revised edition. The monograph gives a systematic treatment of 3-dimensional topological quantum field theories (TQFTs) based on the work of the author with N. Reshetikhin and O. Viro. This subject was inspired by the discovery of the Jones polynomial of knots and the Witten-Chern-Simons field theory. On the algebraic side, the study of 3-dimensional TQFTs has been influenced by the theory of braided categories and the theory of quantum groups. The book is divided into three parts. Part I presents a construction of 3-dimensional TQFTs and 2-dimensional modular functors from so-called modular categories. This gives a vast class of knot invariants and 3-manifold invariants as well as a class of linear representations of the mapping class groups of surfaces. In Part II the technique of 6j-symbols is used to define state sum invariants of 3-manifolds. Their relation to the TQFTs constructed in Part I is established via the theory of shadows. Part III provides constructions of modular categories, based on quantum groups and skein modules of tangles in the 3-space. This fundamental contribution to topological quantum field theory is accessible to graduate students in mathematics and physics with knowledge of basic algebra and topology. It is an indispensable source for everyone who wishes to enter the forefront of this fascinating area at the borderline of mathematics and physics. From the contents: - Invariants of graphs in Euclidean 3-space and of closed 3-manifolds - Foundations of topological quantum field theory - Three-dimensional topological quantum field theory - Two-dimensional modular functors - 6j-symbols - Simplicial state sums on 3-manifolds - Shadows of manifolds and state sums on shadows - Constructions of modular categories. (orig.)

  9. The Art of Electronics - 2nd Edition

    Science.gov (United States)

    Horowitz, Paul; Hill, Winfield

    1989-09-01

    This is the thoroughly revised and updated second edition of the hugely successful The Art of Electronics. Widely accepted as the single authoritative text and reference on electronic circuit design, both analog and digital, the original edition sold over 125,000 copies worldwide and was translated into eight languages. The book revolutionized the teaching of electronics by emphasizing the methods actually used by citcuit designers - a combination of some basic laws, rules to thumb, and a large nonmathematical treatment that encourages circuit values and performance. The new Art of Electronics retains the feeling of informality and easy access that helped make the first edition so successful and popular. It is an ideal first textbook on electronics for scientists and engineers and an indispensable reference for anyone, professional or amateur, who works with electronic circuits. The best self-teaching book and reference book in electronics Simply indispensable, packed with essential information for all scientists and engineers who build electronic circuits Totally rewritten chapters on microcomputers and microprocessors The first edition of this book has sold over 100,000 copies in seven years, it has a market in virtually all research centres where electronics is important

  10. Altered Sleep Homeostasis in Rev-erbα Knockout Mice.

    Science.gov (United States)

    Mang, Géraldine M; La Spada, Francesco; Emmenegger, Yann; Chappuis, Sylvie; Ripperger, Jürgen A; Albrecht, Urs; Franken, Paul

    2016-03-01

    The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of several core clock genes, including Rev-erbα, is modulated by sleep loss. We here test the consequences of a loss of REV-ERBα on the homeostatic regulation of sleep. EEG/EMG signals were recorded in Rev-erbα knockout (KO) mice and their wild type (WT) littermates during baseline, sleep deprivation, and recovery. Cortical gene expression measurements after sleep deprivation were contrasted to baseline. Although baseline sleep/wake duration was remarkably similar, KO mice showed an advance of the sleep/wake distribution relative to the light-dark cycle. After sleep onset in baseline and after sleep deprivation, both EEG delta power (1-4 Hz) and sleep consolidation were reduced in KO mice indicating a slower increase of homeostatic sleep need during wakefulness. This slower increase might relate to the smaller increase in theta and gamma power observed in the waking EEG prior to sleep onset under both conditions. Indeed, the increased theta activity during wakefulness predicted delta power in subsequent NREM sleep. Lack of Rev-erbα increased Bmal1, Npas2, Clock, and Fabp7 expression, confirming the direct regulation of these genes by REV-ERBα also in the brain. Our results add further proof to the notion that clock genes are involved in sleep homeostasis. Because accumulating evidence directly links REV-ERBα to dopamine signaling the altered homeostatic regulation of sleep reported here are discussed in that context. © 2016 Associated Professional Sleep Societies, LLC.

  11. Operational Circular No.2 (Rev. 2) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    2014-01-01

    Operational Circular No. 2 (Rev. 2) entitled “Conditions of access to the fenced parts of the CERN site” and its “implementation measures”, approved by the Director-General following discussion at the Standing Concertation Committee meeting on 20 May 2014 and entering into force on 1 September 2014, are available on the intranet site of the Human Resources Department (see here).   This circular is applicable to members of the personnel and other persons concerned. It cancels and replaces Operational Circular No. 2 (Rev. 1) entitled “Conditions of access to the fenced parts of the CERN site”, of April 1998. In particular, the revised circular provides for the possibility of mandating a person responsible for the proper implementation of the circular, specifies the rules relating to vehicles allowed on the site and the respective responsibilities of their owners, and relaxes certain administrative formalities in case of loss, theft or di...

  12. Administrative circular n°3 (Rev. 2) – Home leave, travel to home station and assimilated leave and travel

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 3 (Rev. 2) entitled “Home leave, travel to the home station and assimilated leave and travel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to employed members of the personnel. It cancels and replaces Administrative Circular No. 3 (Rev. 1) entitled “Travel to the home station and home leave” of June 2002. The circular was revised in order to take into account the new status of Associate Member State and the fact that henceforth, home stations may be situated on territory outside of Europe. It is proposed to introduce a new system of determination of the benefits (Travel expenses, travel time and distance indemnity) granted in the context of home leave and supplementary journeys to the home station.  For t...

  13. Residential Wiring. Teacher Edition [and] Student Edition. Third Edition.

    Science.gov (United States)

    Taylor, Mark; Batson, Larry; Carroll, Charles; Ipock, Dan; Leak, Lester; Onstott, Todd

    This revised curriculum guide for teachers and students is designed to help prepare students for entry-level employment in the residential wiring trade. The curriculum guide contains six units that cover the following topics: (1) blueprint reading and load calculations; (2) service; (3) rough-in; (4) trim out and troubleshooting; (5) low voltage…

  14. CRISPR Genome Editing

    Science.gov (United States)

    A research article about a technique for gene editing known as CRISPR-Cas9. The technique has made it much easier and faster for cancer researchers to study mutations and test new therapeutic targets.

  15. The genome editing revolution

    DEFF Research Database (Denmark)

    Stella, Stefano; Montoya, Guillermo

    2016-01-01

    -Cas system has become the main tool for genome editing in many laboratories. Currently the targeted genome editing technology has been used in many fields and may be a possible approach for human gene therapy. Furthermore, it can also be used to modifying the genomes of model organisms for studying human......In the last 10 years, we have witnessed a blooming of targeted genome editing systems and applications. The area was revolutionized by the discovery and characterization of the transcription activator-like effector proteins, which are easier to engineer to target new DNA sequences than...... sequence). This ribonucleoprotein complex protects bacteria from invading DNAs, and it was adapted to be used in genome editing. The CRISPR ribonucleic acid (RNA) molecule guides to the specific DNA site the Cas9 nuclease to cleave the DNA target. Two years and more than 1000 publications later, the CRISPR...

  16. Human Germline Genome Editing

    OpenAIRE

    Ormond, Kelly E.; Mortlock, Douglas P.; Scholes, Derek T.; Bombard, Yvonne; Brody, Lawrence C.; Faucett, W. Andrew; Garrison, Nanibaa’ A.; Hercher, Laura; Isasi, Rosario; Middleton, Anna; Musunuru, Kiran; Shriner, Daniel; Virani, Alice; Young, Caroline E.

    2017-01-01

    With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Association of Genetic Counsellors, International Genetic Epidemiology Society, and US National Society of Gen...

  17. Benchmark test of JENDL-3T and -3T/Rev.1

    International Nuclear Information System (INIS)

    Takano, Hideki; Kaneko, Kunio.

    1989-10-01

    The fast reactor 70-group constant set JFS-3-J3T has been generated by using the JENDL-3T nuclear data. One-dimensional 21-benchmark cores and the ZPPR-9 core were analysed with the JFS-3-J3T set. The results obtained are summarized as follows: (1) The values of keff are underestimated by 0.6% for Pu-fueled cores and overestimated by 2% for U-fueled cores. (2) The central reaction rate ratio 239 σ f φ/ 235 σ f φ is in a good agreement with the experimental value, though 238 σ c φ/ 239 σ f φ and 238 σ f φ/ 235 σ f φ are overestimated. (3) Doppler and Na-void reactivities are in a good agreement with the measured data. (4) The prediction accuracy of radial reaction rate distributions are improved in the comparison of the results obtained with the JENDL-2 data. Furthermore, the benchmark test of JENDL-3T/Rev. 1 which was revised from JENDL-3T for several important nuclides has been again performed. It was shown that JENDL-3T/Rev. 1 would predict nuclear characteristics more satisfactorily than JENDL-3T. (author)

  18. [Comparison of the compilation features of Science of Meridians and Acupoints among different editions].

    Science.gov (United States)

    Chen, Xiaojun

    The compilation features of Jingluo Shuxue Xue ( Science of Meridians and Acupoints ) among different editions were summarized and analyzed. Jingluo Xue ( Science of Meridians ) and Shuxue Xue ( Science of Acupoints ) published by Shanghai Scientific and Technical Publishers in 1984 are the pioneer as the textbook for the education of acupuncture discipline for the bachelor degree, but there is the big controversy for the editions in 1996. These two books were combined as one, titled Science of Meridians and Acupoints , 2013 edition, published by China Press of Traditional Chinese Medicine. It is concise and coherent in content and is regarded as the milestone in the history of textbook compilation. This book was re-edited in 2007 without major changes in content. The one in 2009 was revised a lot on the basis of the original several editions, published by Shanghai Scientific and Technical Publishers. But unfortunately, it did not bring the big impacts in China. The edition in 2012, published by China Press of Traditional Chinese Medicine had made the innovations besides integrating the achievements of the previous editions, characterized as preciseness and conciseness. By contrast, the edition in 2012, published by People's Medical Publishing House was accomplished by simple modification on the basis of the editions in 2003 and in 2007, without great innovation. Regarding the on-going publication of the textbooks in "the 13th five-year plan", it is viewed that the new edition of textbook should maintain the general framework of "the 12th five-year plan", based on which, a few questions should be revised appropriately. Additionally, "less words, more illustration" should be the basic principle for the revision of the new edition.

  19. Legislation on carriage of dangerous goods. Acts - directives - exemptions. 2. rev. ed.

    International Nuclear Information System (INIS)

    Vogt, H.W.

    1993-01-01

    This compact paperback edition presents the essential chapters of volume 3 'Acts, directives, exemptions' of the publication ''A handbook for dangerous goods officers''. Contents: (1) Act on the Carriage of Dangerous Goods. (2) Ordinance concerning Dangerous Goods Officers (GbV). (3) Legislative intent pursued with the GbV. (4) Instructions for implementation of the GbV. (5) Ordinance on Road Transport of Dangerous Goods (GGVS). (6) Annex A and B of the GGVS. The updating and amendment of the ADR provisions for harmonisation with the international classification schemes and hence the complete revision of categories 4.1, 4.2, 4.3, 5.1, 5.2, and 9, as well as the harmonisation of GGVS provisions with ADR provisions fall both under the 4th Amending Ordinance. This 4th Ordinance Amending the GGVS, passed by the Bundesrat on March 5, 1993 and announced on April 23, 1993, is, of course, part of this edition. Professional subscribers to the publication will prefer the loose-leaf edition of the Handbook for Dangerous Goods Officers, for easy updating of their reference source. (orig./HP) [de

  20. 76 FR 77025 - Office of New Reactors; Notice of Availability of the Final Staff Guidance Section 1.0, Revision...

    Science.gov (United States)

    2011-12-09

    ... the Final Staff Guidance Section 1.0, Revision 2 on Introduction and Interfaces AGENCY: Nuclear... Plants: LWR Edition,'' Section 1.0, Revision 2 on ``Introduction and Interfaces'' (Agencywide Documents Access and Management System (ADAMS) Accession No. ML112730393). The NRC staff issues revisions to SRP...

  1. Brief Report: An Exploratory Study Comparing Diagnostic Outcomes for Autism Spectrum Disorders under DSM-IV-TR with the Proposed DSM-5 Revision

    Science.gov (United States)

    Gibbs, Vicki; Aldridge, Fiona; Chandler, Felicity; Witzlsperger, Ellen; Smith, Karen

    2012-01-01

    The proposed revision for Autism spectrum disorders (ASDs) in the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) represents a shift from the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition, Text Revision (DSM-IV-TR). As the proposed DSM-5 criteria require a higher minimum number of symptoms to be…

  2. Fuel Cell Handbook, Fifth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Energy and Environmental Solutions

    2000-10-31

    Progress continues in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in November 1998. Uppermost, polymer electrolyte fuel cells, molten carbonate fuel cells, and solid oxide fuel cells have been demonstrated at commercial size in power plants. The previously demonstrated phosphoric acid fuel cells have entered the marketplace with more than 220 power plants delivered. Highlighting this commercial entry, the phosphoric acid power plant fleet has demonstrated 95+% availability and several units have passed 40,000 hours of operation. One unit has operated over 49,000 hours. Early expectations of very low emissions and relatively high efficiencies have been met in power plants with each type of fuel cell. Fuel flexibility has been demonstrated using natural gas, propane, landfill gas, anaerobic digester gas, military logistic fuels, and coal gas, greatly expanding market opportunities. Transportation markets worldwide have shown remarkable interest in fuel cells; nearly every major vehicle manufacturer in the U.S., Europe, and the Far East is supporting development. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultrahigh efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 8 describe the six major fuel cell types and their performance based on cell operating conditions. Alkaline and intermediate solid state fuel cells were added to this edition of the Handbook. New information indicates that manufacturers have stayed

  3. Administrative Circular No. 2 (Rev. 6) – Recruitment, appointment and possible developments regarding the contractual position of staff members (1 January 2015)

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 2 (Rev. 6) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 November 2014 is available on the Human Resources Department website. It cancels and replaces Administrative Circular No. 2 (Rev. 5) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" of September 2011. This circular was revised in order to improve the effectiveness of the career transition measures, in particular by expanding the scope of the programme to include also career transition within the Organization and by placing emphasis on career orientation and job search. Administrative Circular No. 2 will be further revised next year with the adoption of the new contract policy, subject to approval of the relevant amendments by all competent bodies. ...

  4. William Gowers: the never completed third edition of the 'Bible of Neurology'.

    Science.gov (United States)

    Eadie, Mervyn J; Scott, Ann E M; Lees, Andrew J; Woodward, Martin

    2012-10-01

    William Gowers' classic single-authored two-volume A manual of diseases of the nervous system appeared in a first edition in 1886 and 1888, and in a second edition in 1892 and 1893, with a third edition of Volume 1 in 1899. No third edition of Volume 2 ever appeared. However, in 1949 Critchley stated that he had seen part of a revision of this volume. Subsequent writers could not find this material, but it recently came to light at Gowers' old hospital at Queen Square, London. The present paper describes the rediscovered material, containing Gowers' handwritten alterations for a further edition of Volume 2, and substantial new material, at least in relation to nystagmus and myasthenia. Gowers' declining health, or a conflict between his planned new text and his contributions to the neurology segments (1899) of Allbutt's System of medicine, may explain why a third edition of Volume 2 of the Manual of diseases of the nervous system never appeared.

  5. [An overview on the collation and revision of medical books by the Bureau for Revising Medical Books in the Northern Song Dynasty].

    Science.gov (United States)

    Meng, Yongliang; Liang, Yongxuan

    2014-07-01

    The Bureau for Revising Medical Books was a temporary agency established by the government of the Northern Song Dynasty in 1057, the 2nd year of Jiayou of Emperor Renzong, exclusively for the edition, revision and publishing of ancient medical books. 11 medical books were revised and edited by 13 Bureau members in a period of 12 years until 1069, the 2nd year of Xining of Emperor ShenZong, which eventually became the final versions until today. 8 medical books were initially planned for the revision, but 11 were actually completed in the end. The time for completing a revision varied from over 10 years at most to less than 1 year at least. Instead of working in the office, the officers of the Bureau for Revising Medical Books did their works at home. The members of the said Bureau came from the Tiju officer of the Bureau for Revising Medical Books and the officials of revising medical books, consisting of both Confucian ministers and medical officers. Confucian ministers played an important role in revising medical books. The Bureau had a strict workflow in electing revising officials, making the project, and the determination of the principles and arrangements of the tasks of editing and proofreading.

  6. Binding and thermodynamics of REV peptide-ctDNA interaction.

    Science.gov (United States)

    Upadhyay, Santosh Kumar

    2017-03-01

    The thermodynamics of DNA-ligand binding is important as it provides useful information to understand the details of binding processes. HIV-1 REV response element (RRE) located in the env coding region of the viral genome is reported to be well conserved across different HIV-1 isolates. In this study, the binding characteristics of Calf thymus DNA (ctDNA) and REV peptide from HIV-1 were investigated using spectroscopic (UV-visible, fluorescence, and circular dichroism (CD)) and isothermal titration calorimetric (ITC) techniques. Thermal stability and ligand binding properties of the ctDNA revealed that native ctDNA had a T m of 75.5 °C, whereas the ctDNA-REV peptide complex exhibited an incremental shift in the T m by 8 °C, indicating thermal stability of the complex. CD data indicated increased ellipticity due to large conformational changes in ctDNA molecule upon binding with REV peptide and two binding stoichiometric modes are apparent. The ctDNA experienced condensation due to large conformational changes in the presence of REV peptide and positive B→Ψ transition was observed at higher molar charge ratios. Fluorescence studies performed at several ligand concentrations revealed a gradual decrease in the fluorescence intensity of EtBr-bound ctDNA in response to increasing ligand concentrations. The fluorescence data further confirmed two stoichiometric modes of binding for ctDNA-REV peptide complex as previously observed with CD studies. The binding enthalpies were determined using ITC in the temperature range of 293 K-308 K. The ITC binding isotherm was exothermic at all temperatures examined, with low ΔH values indicating that the ctDNA-REV peptide interaction is driven largely by entropy. The heat capacity change (ΔC p ) was insignificant, an unusual finding in the area of DNA-peptide interaction studies. The variation in the values obtained for ΔH, ΔS, and ΔG with temperature further suggests that ctDNA-REV peptide interaction is entropically

  7. Editing Audio with Audacity

    Directory of Open Access Journals (Sweden)

    Brandon Walsh

    2016-08-01

    Full Text Available For those interested in audio, basic sound editing skills go a long way. Being able to handle and manipulate the materials can help you take control of your object of study: you can zoom in and extract particular moments to analyze, process the audio, and upload the materials to a server to compliment a blog post on the topic. On a more practical level, these skills could also allow you to record and package recordings of yourself or others for distribution. That guest lecture taking place in your department? Record it and edit it yourself! Doing so is a lightweight way to distribute resources among various institutions, and it also helps make the materials more accessible for readers and listeners with a wide variety of learning needs. In this lesson you will learn how to use Audacity to load, record, edit, mix, and export audio files. Sound editing platforms are often expensive and offer extensive capabilities that can be overwhelming to the first-time user, but Audacity is a free and open source alternative that offers powerful capabilities for sound editing with a low barrier for entry. For this lesson we will work with two audio files: a recording of Bach’s Goldberg Variations available from MusOpen and another recording of your own voice that will be made in the course of the lesson. This tutorial uses Audacity 2.1.2, released January 2016.

  8. Improved adsorption energetics within density-functional theory using revised Perdew-Burke-Ernzerhof functionals

    DEFF Research Database (Denmark)

    Hammer, Bjørk; Hansen, Lars Bruno; Nørskov, Jens Kehlet

    1999-01-01

    A simple formulation of a generalized gradient approximation for the exchange and correlation energy of electrons has been proposed by Perdew, Burke, and Ernzerhof (PBE) [Phys. Rev. Lett. 77, 3865 (1996)]. Subsequently Zhang and Yang [Phys. Rev. Lett. 80, 890 (1998)] have shown that a slight...... revision of the PBE functional systematically improves the atomization energies for a large database of small molecules. In the present work, we show that the Zhang and Yang functional (revPBE) also improves the chemisorption energetics of atoms and molecules on transition-metal surfaces. Our test systems...

  9. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-01-01

    The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised.

  10. Administrative Circular No. 26 (Rev. 7) – May 2007

    CERN Multimedia

    HR Department

    2007-01-01

    Recognition of Merit of Staff Members Administrative Circular No. 26 (Rev. 7) is now available on the intranet site of the Human Resources Department. This circular cancels and replaces Administrative Circular No. 26 (Rev. 6) - Procedures governing the career development of staff members. Copies will shortly be available in Departmental secretariats. If you require any additional information on the new staff-member merit assessment and recognition system, you may consult the FAQ, which has been available on the Human Resources Department intranet site since February 2007. Human Resources Department Tel. 78003

  11. Precision genome editing

    DEFF Research Database (Denmark)

    Steentoft, Catharina; Bennett, Eric P; Schjoldager, Katrine Ter-Borch Gram

    2014-01-01

    Precise and stable gene editing in mammalian cell lines has until recently been hampered by the lack of efficient targeting methods. While different gene silencing strategies have had tremendous impact on many biological fields, they have generally not been applied with wide success in the field...... of glycobiology, primarily due to their low efficiencies, with resultant failure to impose substantial phenotypic consequences upon the final glycosylation products. Here, we review novel nuclease-based precision genome editing techniques enabling efficient and stable gene editing, including gene disruption...... by introducing single or double-stranded breaks at a defined genomic sequence. We here compare and contrast the different techniques and summarize their current applications, highlighting cases from the field of glycobiology as well as pointing to future opportunities. The emerging potential of precision gene...

  12. Human Germline Genome Editing.

    Science.gov (United States)

    Ormond, Kelly E; Mortlock, Douglas P; Scholes, Derek T; Bombard, Yvonne; Brody, Lawrence C; Faucett, W Andrew; Garrison, Nanibaa' A; Hercher, Laura; Isasi, Rosario; Middleton, Anna; Musunuru, Kiran; Shriner, Daniel; Virani, Alice; Young, Caroline E

    2017-08-03

    With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Association of Genetic Counsellors, International Genetic Epidemiology Society, and US National Society of Genetic Counselors. These groups, as well as the American Society for Reproductive Medicine, Asia Pacific Society of Human Genetics, British Society for Genetic Medicine, Human Genetics Society of Australasia, Professional Society of Genetic Counselors in Asia, and Southern African Society for Human Genetics, endorsed the final statement. The statement includes the following positions. (1) At this time, given the nature and number of unanswered scientific, ethical, and policy questions, it is inappropriate to perform germline gene editing that culminates in human pregnancy. (2) Currently, there is no reason to prohibit in vitro germline genome editing on human embryos and gametes, with appropriate oversight and consent from donors, to facilitate research on the possible future clinical applications of gene editing. There should be no prohibition on making public funds available to support this research. (3) Future clinical application of human germline genome editing should not proceed unless, at a minimum, there is (a) a compelling medical rationale, (b) an evidence base that supports its clinical use, (c) an ethical justification, and (d) a transparent public process to solicit and incorporate stakeholder input. Copyright © 2017 American Society of Human Genetics. All rights reserved.

  13. Editing faces in videos

    OpenAIRE

    Amberg, Brian

    2011-01-01

    Editing faces in movies is of interest in the special effects industry. We aim at producing effects such as the addition of accessories interacting correctly with the face or replacing the face of a stuntman with the face of the main actor. The system introduced in this thesis is based on a 3D generative face model. Using a 3D model makes it possible to edit the face in the semantic space of pose, expression, and identity instead of pixel space, and due to its 3D nature allows...

  14. Behaviour Recovery. Second Edition

    Science.gov (United States)

    Rogers, Bill

    2004-01-01

    This second edition of Behaviour Recovery puts emphasis on teaching behaviour concerning children with emotional and behavioural disorders (EBD). These children have many factors in their lives that affect their behaviour over which schools have limited control. This book acknowledges the challenge and explores the practical realities, options and…

  15. Newspaper Editing: English, Journalism.

    Science.gov (United States)

    Bullock, Johanna

    A course designed to groom editors for the newspaper is presented. Editing copy, copyreading and proofreading, principles of headlining, responsibility of the press, libel and slander laws, and problems of censorship are covered. Course objectives include the following: (1) The student will recognize and correct all newspaper items that do not…

  16. Effective Organisational Communication: Perspectives, principles and practices (4th edition)

    OpenAIRE

    Blundel, Richard; Ippolito, Kate; Donnarumma, David

    2013-01-01

    Effective Organisational Communication gives students from all backgrounds the tools to communicate both within and between organisations of all kinds. With thorough coverage of the theoretical background of organisational communication, as well as practical content that helps readers develop their own communication skills, this is the perfect resource for those who want to improve their ability to work effectively with others. \\ud \\ud This heavily revised fourth edition reflects the rapidly ...

  17. Inquiry, A Project of the Wisconsin Bar Foundation. Vols. 1 and 2, Revised.

    Science.gov (United States)

    Scheurich, G. Michael, Ed.

    This new, revised edition of the Inquiry instructional materials is designed for use in teaching high school students about the U. S. laws and legal systems. The revised outlines, designed for instructors who have had legal training, are less technical and more informal, include new concepts and many current relevant topics, and de-emphasize…

  18. Tokamaks (Second Edition)

    Energy Technology Data Exchange (ETDEWEB)

    Stott, Peter [JET, UK (United Kingdom)

    1998-10-01

    The first edition of John Wesson's book on tokamaks, published in 1987, established itself as essential reading for researchers in the field of magnetic confinement fusion: it was an excellent introduction for students to tokamak physics and also a valuable reference work for the more experienced. The second edition, published in 1997, has been completely rewritten and substantially enlarged (680 pages compared with 300). The new edition maintains the aim of providing a simple introduction to basic tokamak physics, but also includes discussion of the substantial advances in fusion research during the past decade. The new book, like its predecessor, is well written and commendable for its clarity and accuracy. In fact many of the chapters are written by a series of co-authors bringing the benefits of a wide range of expertise but, by careful editing, Wesson has maintained a uniformity of style and presentation. The chapter headings and coverage for the most part remain the same - but are expanded considerably and brought up to date. The most substantial change is that the single concluding chapter in the first edition on 'Experiments' has been replaced by three chapters: 'Tokamak experiments' which deals with some of the earlier key experiments plus a selection of recent small and medium-sized devices, 'Large experiments' which gives an excellent summary of the main results from the four large tokamaks - TFTR, JET, JT60/JT60U and DIII-D, and 'The future' which gives a very short (possibly too short in my opinion) account of reactors and ITER. This is an excellent book, which I strongly recommend should have a place - on the desk rather than in the bookshelf - of researchers in magnetic confinement fusion. (book review)

  19. Tokamaks (Second Edition)

    International Nuclear Information System (INIS)

    Stott, Peter

    1998-01-01

    The first edition of John Wesson's book on tokamaks, published in 1987, established itself as essential reading for researchers in the field of magnetic confinement fusion: it was an excellent introduction for students to tokamak physics and also a valuable reference work for the more experienced. The second edition, published in 1997, has been completely rewritten and substantially enlarged (680 pages compared with 300). The new edition maintains the aim of providing a simple introduction to basic tokamak physics, but also includes discussion of the substantial advances in fusion research during the past decade. The new book, like its predecessor, is well written and commendable for its clarity and accuracy. In fact many of the chapters are written by a series of co-authors bringing the benefits of a wide range of expertise but, by careful editing, Wesson has maintained a uniformity of style and presentation. The chapter headings and coverage for the most part remain the same - but are expanded considerably and brought up to date. The most substantial change is that the single concluding chapter in the first edition on 'Experiments' has been replaced by three chapters: 'Tokamak experiments' which deals with some of the earlier key experiments plus a selection of recent small and medium-sized devices, 'Large experiments' which gives an excellent summary of the main results from the four large tokamaks - TFTR, JET, JT60/JT60U and DIII-D, and 'The future' which gives a very short (possibly too short in my opinion) account of reactors and ITER. This is an excellent book, which I strongly recommend should have a place - on the desk rather than in the bookshelf - of researchers in magnetic confinement fusion. (book review)

  20. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-03-14

    Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein) as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  1. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

    Directory of Open Access Journals (Sweden)

    Sheehy Noreen

    2011-03-01

    Full Text Available Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  2. Animals Alive! An Ecological Guide to Animal Activities. Revised Edition.

    Science.gov (United States)

    Holley, Dennis

    This guide is designed to help teachers develop an inquiry-oriented program for studying the animal kingdom in which live animals are collected locally, studied, observed, and then released completely unharmed back into their natural habitats. This book addresses such concerns of life science teachers as the environmental soundness of methods and…

  3. Learning about Sex: Resource Guide for Sex Educators. Revised Edition

    Science.gov (United States)

    Huberman, Barbara

    2011-01-01

    Whether you are someone new to the field of sex education, trying to start a library or resource center on adolescent sexual health, or an old pro, this guide should give you a basic orientation to what's available to support your work. These resources are important to advancing positive attitudes toward adolescent sexual health and the author…

  4. Background Information Relating to Southeast Asia and Vietnam (Revised Edition)

    Science.gov (United States)

    1965-06-16

    jet weapons and armoured vehicles, is prohibited. (b) It is understood, however, that war material, arms and munitions which have been destroyed...12-year Communist subversive effort. Indonesia was less well prepared; it gained its independence too, with our support, but with scars that have

  5. Classroom Creature Culture: Algae to Anoles. Revised Edition.

    Science.gov (United States)

    Hampton, Carolyn H.; And Others

    Identifying and providing the most appropriate classroom environment for living organisms can be time consuming, expensive, and sometimes seemingly impossible. This document, a collection of 2-4 page articles from "Sciences and Children," provides useful information on the collecting and culturing of plants and animals. Among the 43 chapters are:…

  6. Young People with Cancer: A Handbook for Parents. Revised Edition.

    Science.gov (United States)

    National Cancer Inst. (NIH), Bethesda, MD.

    This book informs parents and families of children and young adults with cancer about the most common types of cancer in the young, treatments and their side effects, and common issues that arise with a cancer diagnosis. Aspects of the disease, including characteristics of leukemia and solid tumors, are described. Treatment issues discussed…

  7. The revised edition of korean calendar for allergenic pollens.

    Science.gov (United States)

    Oh, Jae-Won; Lee, Ha-Baik; Kang, Im-Joo; Kim, Seong-Won; Park, Kang-Seo; Kook, Myung-Hee; Kim, Bong-Seong; Baek, Hey-Sung; Kim, Joo-Hwa; Kim, Ja-Kyung; Lee, Dong-Jin; Kim, Kyu-Rang; Choi, Young-Jin

    2012-01-01

    The old calendar of pollens did not reflect current pollen distribution and concentrations that can be influenced by changes of weather and environment of each region in South Korea. A new pollen calendar of allergenic pollens was made based on the data on pollen concentrations obtained in eight regions nationwide between 1997 and 2009. The distribution of pollen was assessed every day at 8 areas (Seoul, Guri, Busan, Daegu, Jeonju, Kwangju, Kangneung, and Jeju) for 12 years between July 1, 1997 and June 30, 2009. Pollens were collected by using Burkard 7-day sampler (Burkard Manufacturing Co Ltd, UK). Pollens which were stained with Calberla's fuchsin staining solution were identified and counted. Pine became the highest pollen in May, and the pollen concentrations of oak and birch also became high. Ragweed appeared in the middle of August and showed the highest pollen concentration in the middles of September. Japanese hop showed a high concentration between the middle of August and the end of September, and mugwort appeared in the middles of August and its concentration increased up until early September. In Kangneung, birch appeared earlier, pine showed a higher pollen concentration than in the other areas. In Daegu, Oriental thuja and alder produced a large concentration of pollens. Pine produced a large concentration of pollens between the middle of April and the end of May. Weeds showed higher concentrations in September and mugwort appeared earlier than ragweed. In Busan the time of flowering is relatively early, and alder and Oriental thuja appeared earliest among all areas. In Kwangju, Oriental thuja and hazelnut appeared in early February. Japanese cedar showed the highest pollen concentration in March in Jeju. In conclusion, update information on pollen calendar in South Korea should be provided for allergic patients through the website to manage and prevent the pollinosis.

  8. Canada Votes: How We Elect Our Government. Second Revised Edition.

    Science.gov (United States)

    Granfield, Linda

    This information book provides a student text on voting procedures in Canada. The short sections provide easy reading on the federal electoral process in Canada. Students read about who can vote, how and when women and minorities won voting rights, the different parties, the voting process --both present and past, and election day happenings.…

  9. British battleships of world war one new revised edition

    CERN Document Server

    Burt, R A

    2012-01-01

    This superb reference book achieved the status of 'classic' soon after its first publication in 1986; it was soon out of print and is now one of the most sought-after naval reference books on the secondhand market.
It presents, in one superb volume, the complete technical history of British capital ship design and construction during the dreadnought era. One hundred years ago at Jutland, Dogger Bank, Heligoland Bight and the first battle for the Falklands, might squadrons of these great armoured ships fought their German counterparts for command of the seas. Beginning with Dreadnought, the book continues to the end of the First World War, and all of the fifty dreadnoughts, 'super-dreadnoughts' and battlecruisers that served the Royal Navy during this era are described and superbly illustrated with photographs and line drawings. 
Each class of ship is described in detail so that design origins, and technical and operational factors, are discussed alongside characteristics, with special emphasis on armament...

  10. Shakespeare: To Teach or Not To Teach. Second Edition. Revised.

    Science.gov (United States)

    Foster, Cass; Johnson, Lynn G.

    Designed to supplement the "Shakespeare for Children" series, this guidebook can be used by teachers who have no dramatic training or particular experience with Shakespeare and with students from elementary to high school. The book begins with a rationale for teaching Shakespeare to children and a comprehensive introduction which…

  11. The Waldorf School Approach to History. Revised Edition.

    Science.gov (United States)

    Glas, Werner

    This publication presents parents, teachers, and educational policy-makers with an account of history instruction in Waldorf schools. An introduction outlines the theoretical content of the Waldorf School movement, the school's emphasis on creating a unity of experience, and the evolution of history instruction through the elementary grade…

  12. Dance Movement Therapy: A Healing Art. [Revised Edition.

    Science.gov (United States)

    Levy, Fran J.

    The concern of this text is the need that many individuals have for nonverbal, primarily physical forms of expression, and how this need has fueled the development of a new psychomotor discipline. The book treats the theory and practice of dance therapy, and examines the entire field from its inception through the present. Dance therapy, the use…

  13. The Waiter and Waitress Training Manual. Revised Edition.

    Science.gov (United States)

    Mitchell, Barbara J.

    This manual is intended for use in pre-employment or upgrading training programs for persons who are planning to work or are presently working in the hotel and restaurant food service industry. Eleven chapters cover interpersonal relationships with employers, fellow employees, and customers; grooming and personal hygiene; sanitary food handling;…

  14. An Economic Course for Elementary School Teachers. Second Revised Edition.

    Science.gov (United States)

    Lovell, Hugh; Harter, Charlotte

    This handbook is intended to help economic educators develop teacher training courses for demonstrating to classroom teachers how to teach economics to children, grades 1-9. Teachers enrolled in the course carry out their own pupil activities which teach economic ideas. These activities include problem solving, case studies, skits, making posters,…

  15. Calculus, Part 3, Teacher's Commentary, Unit No. 71. Revised Edition.

    Science.gov (United States)

    Beck, A.; And Others

    This is part three of a three-part manual for teachers using SMSG high school text materials. The overall purpose for each of the chapters is described and the mathematical development detailed. Background information for key concepts and answers for all exercises in each chapter are provided. Chapter topics include: (1) vectors and curves; (2)…

  16. Bread in a Bag. Teacher's Packet. Revised Edition.

    Science.gov (United States)

    Oklahoma State Dept. of Education, Oklahoma City.

    This unit is designed to familiarize students in grades 3-6 with wheat production; teach them the nutritional value of wheat products and their role in a well-balanced diet; and give then an easy, hands-on experience in bread making with a nominal amount of cleanup for teachers. The kit suggests that in the first week, teachers discuss wheat…

  17. Implementing Metrics at a District Level. Administrative Guide. Revised Edition.

    Science.gov (United States)

    Borelli, Michael L.; Morelli, Sandra Z.

    Administrative concerns in implementing metrics at a district level are discussed and specific recommendations are made regarding them. The paper considers the extent and manner of staff training necessary, the curricular changes associated with metrics, and the distinctions between elementary and secondary programs. Appropriate instructional…

  18. Teaching Measurement to Children: Grades K-6. Revised Edition.

    Science.gov (United States)

    Borelli, Michael L.; Morelli, Sandra Z.

    Objectives are listed describing the progression which students follow in learning to measure. These objectives follow a sequence that corresponds closely with the intellectual sequence found in students' learning. Grade-level recommendation charts follow the objectives. Topics dealt with are length, distance, area, volume, capacity, mass, and…

  19. Planning, Promoting and Passing School Tax Issues. [Revised Edition].

    Science.gov (United States)

    Whitman, Robert L.; Pittner, Nicholas A.

    This book provides Ohio citizens with information on school tax issues and levy campaigning. The material is presented in a structural step-by-step process that lends itself to the practical application for preparing a levy. This book is a guide to understanding various tax issues, tax reduction factors, and the changing tax duplicate that affects…

  20. Primary Treatment and Sludge Digestion Workshop. Second Edition (Revised).

    Science.gov (United States)

    Ontario Ministry of the Environment, Toronto.

    This manual was developed for use at workshops designed to upgrade the knowledge of experienced wastewater treatment plant operators. Each of the sixteen lessons has clearly stated behavioral objectives to tell the trainee what he should know or do after completing that topic. The body of the text provides content information, procedure outlines,…

  1. Calculus of Elementary Functions, Part II. Teacher's Commentary. Revised Edition.

    Science.gov (United States)

    Herriot, Sarah T.; And Others

    This course is intended for students who have a thorough knowledge of college preparatory mathematics, including algebra, axiomatic geometry, trigonometry, and analytic geometry. This teacher's guide is for Part II of the course. It is designed to follow Part I of the text. The guide contains background information, suggested instructional…

  2. Calculus of Elementary Functions, Part II. Student Text. Revised Edition.

    Science.gov (United States)

    Herriot, Sarah T.; And Others

    This course is intended for students who have a thorough knowledge of college preparatory mathematics, including algebra, axiomatic geometry, trigonometry, and analytic geometry. This text, Part II, contains material designed to follow Part I. Chapters included in this text are: (6) Derivatives of Exponential and Related Functions; (7) Area and…

  3. Calculus of Elementary Functions, Part I. Teacher's Commentary. Revised Edition.

    Science.gov (United States)

    Herriot, Sarah T.; And Others

    This course is intended for students who have a thorough knowledge of college preparatory mathematics including algebra, axiomatic geometry, trigonometry, and analytic geometry. It does not assume they have acquired a background of elementary functions. This teacher's guide contains background information, suggested instructional procedures, and…

  4. Calculus of Elementary Functions, Part I. Student Text. Revised Edition.

    Science.gov (United States)

    Herriot, Sarah T.; And Others

    This course is intended for students who have a thorough knowledge of college preparatory mathematics, including algebra, axiomatic geometry, trigonometry, and analytic geometry. This text, Part I, contains the first five chapters of the course and two appendices. Chapters included are: (1) Polynomial Functions; (2) The Derivative of a Polynomial…

  5. The Instructional Guide for Abbott Skills Enhancement Classes. Revised Edition.

    Science.gov (United States)

    Ballinger, Ronda; Gee, Mary Kay

    This guide, which integrates adult basic education (ABE) curriculum, job skills for Abbott Laboratories, and work-related foundation skills, is designed for an instructional program in the skill areas of reading, writing, oral communications, mathematics, and problem solving. In addition to creating a uniform process and product to promote…

  6. Solar Energy Education Packet for Elementary & Secondary Students. Revised Edition.

    Science.gov (United States)

    Center for Renewable Resources, Washington, DC.

    The arrangement of this packet is essentially evolutionary, with a conscious effort to alternate reading assignments, activities and experiments. It begins with solar energy facts and terminology as background to introduce the reader to basic concepts. It progresses into a discussion of passive solar systems. This is followed by several projects…

  7. Silver Drawing Test of Cognition and Emotion. Third Edition, Revised.

    Science.gov (United States)

    Silver, Rawley

    This test, the Silver Drawing Test (SDT), evolved from a belief that the intelligence of children and adults who have poor language skills tends to be underestimated. The aim of the SDT is to provide an instrument for assessing the cognitive skills of individuals who have difficulty understanding others and making themselves understood. There are…

  8. User's Manual. Vocational Education Readiness Test (VERT). Revised Edition.

    Science.gov (United States)

    Thomas, Edward L.; And Others

    This user's manual provides information suggesting various ways in which educational personnel may wish to utilize the eight modules included in the Vocational Education Readiness Test (VERT). The introductory section presents questions which can be used by school personnel to determine whether or not VERT will be useful in their school system.…

  9. Pictorial English/Haitian-Creole Dictionary. Revised Edition.

    Science.gov (United States)

    Vilsaint, Fequiere; Heurtelou, Maude

    The English-to-Haitian Creole (HC) dictionary contains simple, direct translations of English words to HC using line drawings. Words are organized by theme: plants; food and drinks; animals; people; ethnicity; clothes; body parts; first aid; buildings; inside the house; hygiene; sport, hobbies, and games; musical instruments; tools; measuring…

  10. A guide to radiologic methods of diagnosis. 9. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Thurn, P.; Buecheler, E.; Frommhold, H.

    1992-01-01

    With the 9th edition of this guide an attempt was made to take account of technical innovations in radiology and the appropriate range of indications. Attention was mainly focused on the various possibilities offered at the clinical level by high-resolution computed tomography as well as nmr imaging and digitized radiography. The chapter on radioprotection and radiation injuries has been rewritten and updated through the addition of recently prepared tables. The clinical chapters chiefly deal with the roles of nmr imaging and computed tomography. This applies in particular to discussions relating to the central nervous system, facial skull, cervical region and soft tissues. Radiologic methods of intervention were given some coverage. The chapter on contrast media and mishaps attributable to these was completely revised. (orig./MG) With 761 figs., 29 tabs [de

  11. Nuclear medicine. Basic knowledge and clinical applications. 6. rev. and upd. ed.

    International Nuclear Information System (INIS)

    Schicha, H.; Schober, O.

    2007-01-01

    The development of imaging techniques like SPECT, SPECT-CT, PET, PET-CT and MRT has advanced rapidly during the past few years, especially in the case of hybrid technology. These techniques have become indispensable in diagnosis, differential diagnosis, therapy follow-up and prevention. This 6th revised and edited version of 'Nuclear Medicine' takes account of these developments. The general section presents fundamentals of physics, radiopharmaceutical chemistry, measuring techniques, nuclear medical examination techniques, and dosimetry. The special section presents detailed descriptions of all relevant nuclear medical techniques by organ systems and clinical pictures. There are many examples and scintiscans of organs to train the diagnostic eye and give a link to clinical practice. This successful textbook presents complex subject matter in a clear and intelligible way. It addresses newcomers and expert doctors that require training in nuclear medical methods. It has also become a standard textbook in university medicine studies and in the training of radiological assistants. (orig.)

  12. Computerized tomography. Fundamentals, equipment, image quality, applications. 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Kalender, W.A.

    2006-01-01

    The book provides a clear and user-oriented outline of the theoretical and technical fundamentals of computerized tomography for a wide range of readers, from conventional CT to volume CT with conical beams. Image quality, its relevant influencing parameters and the performance factors to be observed for clinical application are discussed in detail, as are dose requirements, dose metering and dose reduction measures in CT. The second, revised edition contains updated information and also presents new technologies. A CD-ROM with attractive exemplary appications, animations and interactive exercises in image interpretation and manipulation is included. The book addresses everyone concerned with CT, either in their daily routine or even only every now and then, i.e. physicians, medical assistants, engineers, technicians and physicists. The book also contains a glossary of technical terms. (orig.)

  13. The thermodynamics of heat- and mass exchange in chemical engineering. Vol. 1. 2. rev. ed.

    International Nuclear Information System (INIS)

    Matz, G.

    1979-01-01

    The second and completely revised edition of the approved textbook 'The thermodynamics of heat- and mass exchange in chemical engineering' is devoted to students of technical and natural science disciplines as well as to practicians and scientists, which are confronted with thermodynamical problems of chemical engineering. Starting from the different phases and properties of matter, the first and the second law of thermodynamics are discussed together with many applications. After an introduction of the equilibrium state, the general principle of similarity for heat- and mass exchange is discussed, considering in particular the heat- and mass exchange in the counter flow between two phases. In a final chapter, the heat- and mass exchange between the vapor- and liquid phase is discussed, with special emphasis on problems as evaporation and drying. (orig./HK) [de

  14. Pocket atlas of radiographic anatomy. 2. rev. ed.; Taschenatlas der Roentgenanatomie

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, T.B.; Reif, E. [Caritas-Krankenhaus, Dillingen (Germany)

    1998-07-01

    This pocket atlas is the second, revised German edition of the pocket atlas of radiographic anatomy. All anatomic structures of clinical relevance are reproduced according to the split page concept, showing the radiographs, the accompanying drawings and the clinical terminology. (orig./CB) [German] Diese 2. ueberarbeitete Auflage des Taschenatlas der Roentgenanatomie und zeichnet sich aus durch folgende Aspekte: - Hoher Informationsgehalt: alle gaengigen Standard- und Spezialeinstellungen der konventionellen Radiologie einschliesslich aller Kontrastmitteluntersuchungen werden beschrieben. - Praezise im Detail: alle klinisch relevanten anatomischen Strukturen werden in einer dem Roentgenbild direkt gegenuebergestellten Zeichnung wiedergegeben und benannt. Der Benennung liegt die klinisch gebraeuchliche Terminologie zugrunde. - Immer griffbereit, handlich und uebersichtlich: das praktische Taschenbuchformat macht es leicht, das Buch immer dabeizuhaben. Der einfache Aufbau erspart muehsames Suchen in Inhalts- oder Sachverzeichnissen. (orig.)

  15. Planning Facilities for Athletics, Physical Education and Recreation. Revised.

    Science.gov (United States)

    American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD).

    This revised edition includes new material recommended by a panel of experts in the field of recreational planning. The following topics are covered: (1) the planning process; (2) indoor facilities; (3) outdoor facilities; (4) indoor and outdoor swimming pools; (5) encapsulated spaces and stadiums; (6) service areas; (7) recreation and park…

  16. Fan edits and the legacy of The Phantom Edit

    Directory of Open Access Journals (Sweden)

    Joshua Wille

    2014-09-01

    Full Text Available A fan edit can generally be defined as an alternative version of a film or television text created by a fan. It offers a different viewing experience, much as a song remix offers a different listening experience. The contemporary wave of fan edits has emerged during the remix zeitgeist of digital media and at a time when digital video editing technology has become more affordable and popular. The increasing number of alternative versions of films and the works of revisionist Hollywood filmmakers such as George Lucas have contributed to a greater public understanding of cinema as a fluid medium instead of one that exists in a fixed form. The Phantom Edit (2000, a seminal fan edit based on Lucas's Star Wars Episode I: The Phantom Menace (1999, inspired new ranks of fan editors. However, critics have misunderstood fan edits as merely the work of disgruntled fans. In order to provide a critical and historical basis for studies in fan editing as a creative practice, I examine previous interpretations of fan edits in the context of relevant contemporary works, and I use an annotated chronology of The Phantom Edit to trace its influence on subsequent fan editing communities and uncover their relationship with intellectual property disputes.

  17. A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev

    International Nuclear Information System (INIS)

    Fang Jianhua; Kubota, Satoshi; Yang Bin; Zhou Naiming; Zhang Hui; Godbout, Roseline; Pomerantz, Roger J.

    2004-01-01

    HIV-1 Rev escorts unspliced viral mRNAs out of the nucleus of infected cells, which allows formation of infectious HIV-1 virions. We have identified a putative DEAD box (Asp-Glu-Ala-Asp) RNA helicase, DDX1, as a cellular co-factor of Rev, through yeast and mammalian two-hybrid systems using the N-terminal motif of Rev as 'bait'. DDX1 is not a functional homolog of HIV-1 Rev, but down-regulation of DDX1 resulted in an alternative splicing pattern of Rev-responsive element (RRE)-containing mRNA, and attenuation of Gag p24 antigen production from HLfb rev(-) cells rescued by exogenous Rev. Co-transfection of a DDX1 expression vector with HIV-1 significantly increased viral production. DDX1 binding to Rev, as well as to the RRE, strongly suggest that DDX1 affects Rev function through the Rev-RRE axis. Moreover, down-regulation of DDX1 altered the steady state subcellular distribution of Rev, from nuclear/nucleolar to cytoplasmic dominance. These findings indicate that DDX1 is a critical cellular co-factor for Rev function, which maintains the proper subcellular distribution of this lentiviral regulatory protein. Therefore, alterations in DDX1-Rev interactions could induce HIV-1 persistence and targeting DDX1 may lead to rationally designed and novel anti-HIV-1 strategies and therapeutics

  18. Quantum field theory. From operators to path integrals. 2. rev. and enl. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Kerson

    2010-07-01

    A new, updated and enhanced edition of the classic work, which was welcomed for its general approach and self-sustaining organization of the chapters. Written by a highly respected textbook writer and researcher, this book has a more general scope and adopts a more practical approach than other books. It includes applications of condensed matter physics, first developing traditional concepts, including Feynman graphs, before moving on to such key topics as functional integrals, statistical mechanics and Wilson's renormalization group. The author takes care to explain the connection between the latter and conventional perturbative renormalization. Due to the rapid advance and increase in importance of low dimensional systems, this second edition fills a gap in the market with its added discussions of low dimensional systems, including one-dimensional conductors. All the chapters have been revised, while more clarifying explanations and problems have been added. A noteworthy new topic is Polchinski's renormalization equation, which is derived, and then solved to obtain the Halpern-Huang asymptotically free scalar field. The latter has found application in the dark-energy problem in cosmology. (orig.)

  19. Quantum field theory. From operators to path integrals. 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Huang, Kerson

    2010-01-01

    A new, updated and enhanced edition of the classic work, which was welcomed for its general approach and self-sustaining organization of the chapters. Written by a highly respected textbook writer and researcher, this book has a more general scope and adopts a more practical approach than other books. It includes applications of condensed matter physics, first developing traditional concepts, including Feynman graphs, before moving on to such key topics as functional integrals, statistical mechanics and Wilson's renormalization group. The author takes care to explain the connection between the latter and conventional perturbative renormalization. Due to the rapid advance and increase in importance of low dimensional systems, this second edition fills a gap in the market with its added discussions of low dimensional systems, including one-dimensional conductors. All the chapters have been revised, while more clarifying explanations and problems have been added. A noteworthy new topic is Polchinski's renormalization equation, which is derived, and then solved to obtain the Halpern-Huang asymptotically free scalar field. The latter has found application in the dark-energy problem in cosmology. (orig.)

  20. Dictionary of power engineering and automation. Pt. 1. 3. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Bezner, H.

    1993-01-01

    The dictionary has been prepared by the Translation Department of Siemens AG and essentially covers the following subjects: Basic electrotechnical terms and standards, Electrical machines (including transformers), Switchgear, Electrical systems and networks, Electrical installation practice (including lighting), Power cables, Power electronics, Protective devices and relays, Electrical measuring and analysis technology, Telecontrol, Automotive electronics, Semiconductor devices, integrated circuits, Automation technology (control engineering, programmable and numerical controls, process control), Bus systems, communication networks, data transmission and communication, Test engineering, Quality assurance and reliability. For the third edition, the dictionary has been thoroughly revised and about 2000 terms have been added, primarily referring to the subject of process control, so that the edition in hand contains approximately 65 000 entires. Sources referred to for this dictionary include: VDE specifications, DIN, VDI, IEC, BS, ANSI, CEE and ISO standards, technical literature and descriptions and operating instructions from German, British and American companies. The results of the European harmonization of electrotechnical regulations (DIN/ VDE/IEC/CEE) have been taken into account. (orig./HP) [de

  1. Operational circular No. 1 (Rev. 1) – Operational circulars

    CERN Multimedia

    HR Department

    2011-01-01

    Operational Circular No. 1 (Rev. 1) is applicable to members of the personnel and other persons concerned. Operational Circular No. 1 (Rev. 1) entitled "Operational circulars", approved following discussion at the Standing Concertation Committee meeting on 4 May 2011, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 1 entitled "Operational Circulars” of December 1996. This new version clarifies, in particular, that operational circulars do not necessarily arise from the Staff Rules and Regulations, and the functional titles have been updated to bring them into line with the current CERN organigram. Department Head Office  

  2. Meteorological explanation of wake clouds at Horns Rev wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Emeis, S. [Karlsruhe Institute of Technology (Germany). Inst. for Meteorology and Climate Research

    2010-08-15

    The occurrence of wake clouds at Horns Rev wind farm is explained as mixing fog. Mixing fog forms when two nearly saturated air masses with different temperature are mixed. Due to the non-linearity of the dependence of the saturation water vapour pressure on temperature, the mixed air mass is over-saturated and condensation sets in. On the day in February 2008, when the wake clouds were observed at Horns Rev, cold and very humid air was advected from the nearby land over the warmer North Sea and led to the formation of a shallow layer with sea smoke or fog close above the sea surface. The turbines mixed a much deeper layer and thus provoked the formation of cloud trails in the wakes of the turbines. (orig.)

  3. Arrangements for transition from the 1985 edition (as amended 1990) to the 1996 edition of the IAEA Transport Regulations

    International Nuclear Information System (INIS)

    2001-01-01

    In December 1996 the International Atomic Energy Agency published the 1996 Edition of the Regulations for the Safe Transport of Radioactive Material (formerly Safety Series No. 6) in a document called ST-1. That document has served as the basis for revising the UN Committee of Experts Recommendations on the Safe Transport of Dangerous Goods (published in 1999 as ''Model Regulations''), and as the basis for the Class 7 portions of the forthcoming revisions of RID, ADR, IMO (IMDG Code), ICAO (Technical Instructions) and IATA modal dangerous goods regulations. ST-1 was subsequently reviewed and revised with minor editorial corrections, and in 2000, a revised English version of the regulations called TS-R-1 (ST-1, Revised) was published. Difficulties may arise when applying the Regulations during the transition from the 1985 Edition of the Transport Regulations to the 1996 Edition of these regulations. These difficulties come mainly from the differences between the two sets of regulations, e.g. the definition of radioactive material with the new nuclide specific exemption levels, the new values of A 1 /A 2 , the annual dose limits, the related documentation, the labelling requirements for fissile material package, the changes in UN numbers and proper shipping names, the shipment of fissile material by air, etc. This TECDOC is intended to provide guidance on the implementation of changes in the Regulations for the Safe Transport of Radioactive Material. This guidance may be used to facilitate compliance with the Regulations. This guidance is aimed at all users of the regulations including National Competent Authorities, consignors, consignees and carriers

  4. REV-ERB and ROR: therapeutic targets for treating myopathies

    Science.gov (United States)

    Welch, Ryan D.; Flaveny, Colin A.

    2017-08-01

    Muscle is primarily known for its mechanical roles in locomotion, maintenance of posture, and regulation of cardiac and respiratory function. There are numerous medical conditions that adversely affect muscle, myopathies that disrupt muscle development, regeneration and protein turnover to detrimental effect. Skeletal muscle is also a vital secretory organ that regulates thermogenesis, inflammatory signaling and directs context specific global metabolic changes in energy substrate preference on a daily basis. Myopathies differ in the causative factors that drive them but share common features including severe reduction in quality of life and significantly increased mortality all due irrefutably to the loss of muscle mass. Thus far clinically viable approaches for preserving muscle proteins and stimulating new muscle growth without unwanted side effects or limited efficacy has been elusive. Over the last few decades, evidence has emerged through in vitro and in vivo studies that suggest the nuclear receptors REV-ERB and ROR might modulate pathways involved in myogenesis and mitochondrial biogenesis. Hinting that REV-ERB and ROR might be targeted to treat myopathies. However there is still a need for substantial investigation into the roles of these nuclear receptors in in vivo rodent models of degenerative muscle diseases and acute injury. Although exciting, REV-ERB and ROR have somewhat confounding roles in muscle physiology and therefore more studies utilizing in vivo models of skeletal muscle myopathies are needed. In this review we highlight the molecular forces driving some of the major degenerative muscular diseases and showcase two promising molecular targets that may have the potential to treat myopathies: ROR and REV-ERB.

  5. ENDF/B-5 Fission Products Library. Rev. 2

    International Nuclear Information System (INIS)

    Schwerer, O.; Pronyaev, V.G.; Lemmel, H.D.

    1984-07-01

    This document summarizes contents and documentation of the 1984 version of the Fission Products Nuclear Data File of the ENDF/B-5 Library (Rev. 2) maintained by the National Nuclear Data Center (NNDC) at the Brookhaven National Laboratory, USA. This file contains numerical neutron reaction data and decay data for 877 fission product nuclides. The entire file or selective retrievals from it can be obtained on magnetic tape from the IAEA Nuclear Data Section. (author)

  6. Preface to Special Edition

    Directory of Open Access Journals (Sweden)

    Renee Nathanson

    2012-04-01

    Full Text Available Given that reading comprehension is at the forefront of global literacy discourse, this special edition of Per Linguam, the first number that is also published online, features a collection of articles that cover different aspects of reading comprehension and instruction, such as, strategies for comprehending texts, metacognitive awareness, the reciprocity of assessment and comprehension instruction and socio-affective factors that influence comprehension.

  7. Genome Editing of Monkey.

    Science.gov (United States)

    Liu, Zhen; Cai, Yijun; Sun, Qiang

    2017-01-01

    Gene-modified monkey models would be particularly valuable in biomedical and neuroscience research. Virus-based transgenic and programmable nucleases-based site-specific gene editing methods (TALEN, CRISPR-cas9) enable the generation of gene-modified monkeys with gain or loss of function of specific genes. Here, we describe the generation of transgenic and knock-out (KO) monkeys with high efficiency by lentivirus and programmable nucleases.

  8. Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

    Science.gov (United States)

    Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M

    2017-02-01

    HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide

  9. Administrative Circulars No. 12 A (Rev. 2) - "Education fees” and No. 12 B (Rev. 2) - “Education fees and language courses”

    CERN Multimedia

    2013-01-01

    Administrative Circulars No. 12 A (Rev. 2) entitled “Education fees” and No. 12 B (Rev. 2) entitled “Education fees and language courses”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, are available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 12 A (Rev. 2) is applicable to Staff Members (except former “Local Staff Members”) recruited before 1st January 2007. Administrative Circular No. 12 B (Rev. 2) is applicable to Staff Members recruited on or after 1st January 2007, to Fellows, to Scientific Associates, to Guest Professors and to former “Local Staff” recruited before 1st January 2007. They cancel and replace Administrative Circulars No. 12 A (Rev. 1/Corr.) entitled "Education fees” and No. 12 B (Rev. 1/Corr.) entitled “Edu...

  10. Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.

    Science.gov (United States)

    Bogerd, H P; Wiegand, H L; Yang, J; Cullen, B R

    2000-10-01

    Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor. Human endogenous retrovirus K, a family of ancient endogenous retroviruses that is not related to the exogenous retrovirus HIV-1, was recently shown to also encode a Crm1-dependent nuclear RNA export factor, termed K-Rev. Although HIV-1 Rev and K-Rev display little sequence identity, they share the ability not only to bind to Crm1 and to RNA but also to form homomultimers and shuttle between nucleus and cytoplasm. We have used mutational analysis to identify sequences in the 105-amino-acid K-Rev protein required for each of these distinct biological activities. While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export. Although several nonfunctional K-Rev mutants acted as dominant negative inhibitors of K-Rev-, but not HIV-1 Rev-, dependent RNA export, these were not defined by their inability to bind to Crm1, as is seen with HIV-1 Rev. In total, this analysis suggests a functional architecture for K-Rev that is similar to, but distinct from, that described for HIV-1 Rev and raises the possibility that viral RNA export mediated by the approximately 25 million-year-old K-Rev protein may require an additional cellular cofactor that is not required for HIV-1 Rev function.

  11. Test Review: Constantino, J. N., & Gruber, C. P. (2012). "Social Responsiveness Scale-Second Edition" ("SRS-2"). Torrance, CA: Western Psychological Services

    Science.gov (United States)

    Bruni, Teryn P.

    2014-01-01

    This article reviews the Social Responsiveness Scale-Second Edition (SRS-2), a 65-item rating scale measuring deficits in social behavior associated with Autism Spectrum Disorder (ASD), as outlined by the "Diagnostic and Statistical Manual of Mental Disorders" (4th ed., text rev.; "DSM-IV-TR"; American Psychiatric Association,…

  12. UV-induced reversion of his4 frameshift mutations in rad6, rev1, and rev3 mutants of yeast.

    Science.gov (United States)

    Lawrence, C W; O'Brien, T; Bond, J

    1984-01-01

    The UV-induced reversion of two his4 frameshift alleles was much reduced in rad6 mutants of Saccharomyces cerevisiae, an observation that is consistent with the hypothesis that RAD6 function is required for the induction of all types of genetic alteration in misrepair mutagenesis. The reversion of these his4 alleles, together with two others of the same type, was also reduced in rev1 and rev3 mutant strains; in these, however, the extent of the reduction varied considerably with test allele used, in a manner analogous to the results in these strains for base repair substitution test alleles. The general features of UV-induced frameshift and substitution mutagenesis therefore appear quite similar, indicating that they may depend on related processes. If this conclusion is correct, greater attention must be given to integrating models which account for the production of nucleotide additions and deletions into those concerning misrepair mutagenesis.

  13. Fusion. An introduction of the physics and technology of magnetic confinement fusion. 2. compl. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Stacey, Weston M.

    2010-01-01

    This second edition of a popular textbook is thoroughly revised with around 25% new and updated content. It provides an introduction to both plasma physics and fusion technology at a level that can be understood by advanced undergraduates and graduate students in the physical sciences and related engineering disciplines. As such, the contents cover various plasma confinement concepts, the support technologies needed to confine the plasma, and the designs of ITER as well as future fusion reactors. With end of chapter problems for use in courses. (orig.)

  14. Sampling and estimation techniques for the implementation of new classification systems: the change-over from NACE Rev. 1.1 to NACE Rev. 2 in business surveys

    Directory of Open Access Journals (Sweden)

    Jan van den Brakel

    2010-09-01

    Full Text Available This paper describes some of the methodological problems encountered with the change-over from the NACE Rev. 1.1 to the NACE Rev. 2 in business statistics. Different sampling and estimation strategies are proposed to produce reliable figures for the domains under both classifications simultaneously. Furthermore several methods are described that can be used to reconstruct time series for the domains under the NACE Rev. 2.

  15. Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas

    Science.gov (United States)

    New Hampshire Fleet Revs up With Natural Gas to someone by E-mail Share Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Facebook Tweet about Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Twitter Bookmark Alternative Fuels Data Center

  16. Stirling engine design manual, 2nd edition

    Science.gov (United States)

    Martini, W. R.

    1983-01-01

    This manual is intended to serve as an introduction to Stirling cycle heat engines, as a key to the available literature on Stirling engines and to identify nonproprietary Stirling engine design methodologies. Two different fully described Stirling engines are discussed. Engine design methods are categorized as first order, second order, and third order with increased order number indicating increased complexity. FORTRAN programs are listed for both an isothermal second order design program and an adiabatic second order design program. Third order methods are explained and enumerated. In this second edition of the manual the references are updated. A revised personal and corporate author index is given and an expanded directory lists over 80 individuals and companies active in Stirling engines.

  17. Writing, Proofreading and Editing in Information Theory

    Directory of Open Access Journals (Sweden)

    J. Ricardo Arias-Gonzalez

    2018-05-01

    Full Text Available Information is a physical entity amenable to be described by an abstract theory. The concepts associated with the creation and post-processing of the information have not, however, been mathematically established, despite being broadly used in many fields of knowledge. Here, inspired by how information is managed in biomolecular systems, we introduce writing, entailing any bit string generation, and revision, as comprising proofreading and editing, in information chains. Our formalism expands the thermodynamic analysis of stochastic chains made up of material subunits to abstract strings of symbols. We introduce a non-Markovian treatment of operational rules over the symbols of the chain that parallels the physical interactions responsible for memory effects in material chains. Our theory underlies any communication system, ranging from human languages and computer science to gene evolution.

  18. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs

    International Nuclear Information System (INIS)

    Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang; Liu, Chao; Zhang, Hui

    2015-01-01

    Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.

  19. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Liu, Chao, E-mail: liuchao9@mail.sysu.edu.cn [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Zhang, Hui [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China)

    2015-12-15

    Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.

  20. Stable isotope geochemistry. 3. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Hoefs, J.

    1987-01-01

    Stable Isotope Geochemistry is an authoritative book comprising theoretical and experimental principles; surveying important fractionation mechanisms affecting the most important elements; discussing the natural variations of geologically important reservoirs. This updated 3rd edition, with a completely rewritten and extended main part, contains two new chapters on stable isotope composition of mantle material and on changes of the ocean during the geological past. (orig.)

  1. REDIdb: the RNA editing database.

    Science.gov (United States)

    Picardi, Ernesto; Regina, Teresa Maria Rosaria; Brennicke, Axel; Quagliariello, Carla

    2007-01-01

    The RNA Editing Database (REDIdb) is an interactive, web-based database created and designed with the aim to allocate RNA editing events such as substitutions, insertions and deletions occurring in a wide range of organisms. The database contains both fully and partially sequenced DNA molecules for which editing information is available either by experimental inspection (in vitro) or by computational detection (in silico). Each record of REDIdb is organized in a specific flat-file containing a description of the main characteristics of the entry, a feature table with the editing events and related details and a sequence zone with both the genomic sequence and the corresponding edited transcript. REDIdb is a relational database in which the browsing and identification of editing sites has been simplified by means of two facilities to either graphically display genomic or cDNA sequences or to show the corresponding alignment. In both cases, all editing sites are highlighted in colour and their relative positions are detailed by mousing over. New editing positions can be directly submitted to REDIdb after a user-specific registration to obtain authorized secure access. This first version of REDIdb database stores 9964 editing events and can be freely queried at http://biologia.unical.it/py_script/search.html.

  2. Safe Handling of Radioisotopes. 1973 Edition

    International Nuclear Information System (INIS)

    1973-01-01

    Under its Statute the International Atomic Energy Agency is empowered to provide for the application of standards of safety for protection against radiation to its own operations and to operations making use of assistance provided by it or with which it is otherwise directly associated. To this end authorities receiving such assistance are required to observe relevant health and safety measures prescribed by the Agency. As a first step, it was considered an urgent task to provide users of radionuclides with a manual of practice for the safe handling of these substances. The first edition of such a manual was published in 1958 and represented the first of the ''Safety Series'', a series of manuals and codes on health and safety published by the Agency. It was prepared after careful consideration of existing national and international codes of radiation safety by a group of international experts and in consultation with other international bodies. This edition presents the second revision. In response to the suggestion made by some Member States, the term 'radioisotopes' has been changed to 'radionuclides' in the title and, as appropriate, in the text because the term 'radionuclides' includes the radioactive element itself as well as the isotopes. The series of manuals and codes published in the Safety Series and the Technical Reports Series give more complete advice to the user on specialized topics.

  3. Administrative circular No.14 (Rev. 3) – Protection of members of the personnel against the financial consequences of illness, accident and incapacity for work

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 14 (Rev. 3) entitled “Protection of members the personnel against the financial consequences of illness, accident and incapacity for work”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 19 April 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 14 (Rev. 2) entitled “Protection of members of the personnel against the financial consequences of illness, accident and disability” from July 2006. The circular was revised in order to improve the procedure before the Joint Advisory Rehabilitation and Disability Board (JARDB) and the management of long-term sick leave through a multidisciplinary approach launched upstream. The aim of this approach is to allow staff/fellows c...

  4. The Craft of Editing

    DEFF Research Database (Denmark)

    Moeran, Brian

    To edit is to make a choice, or series of choices. Will I write a rough draft of this essay in longhand, or hammer it out on my computer? If the latter, what font shall I use? Times New Roman, Book Antiqua, or Garamond? Once I get started, what style shall I adopt: realistic, confessional or impr...... or impressionistic; or a combination of all three (Van Maanen 1988)? Should I try to impress with ‘learned scholarship’, or should I merely outline in conversational English a few thoughts based on my own experiences?...

  5. Peer-editing Practice in the Writing Classroom: Benefits and Drawbacks

    Directory of Open Access Journals (Sweden)

    Ann Rosnida Md. Deni

    2011-01-01

    Full Text Available Small scale studies have shown that peer-editing is beneficial to students as it increases their awareness of the complex process of writing, it improves their knowledge of and skills in writing and helps them become more autonomous in learning. Teachers too may benefit from peer-editing as this practice discloses invaluable information on students’ writing weaknesses and strengths: and teachers’ teaching effectiveness. This is a small scale study conducted on fifteen first-year degree students majoring in Tourism to view the usefulness of peer-editing practice in enhancing their writing skills. Retrospective notes were taken to record students’ receptiveness and reaction towards peer editing practice: students writing samples and peer- editing questionnaires were analyzed to view students’ revisions and comments; and an open— ended questionnaire was distributed to identify students perceptions of peer—editing practice in the writing classroom. Analysis of data gathered revealed that peer-editing practice benefitted both the teacher and most of her students as it exposed important information that could improve her teaching of writing and her students’ writing practices. Data analysis also. however, discloses that peer-editing practice may have adverse effects on students’ motivation and improvement in writing if they are not deployed properly.

  6. Wind Farm Wake: The Horns Rev Photo Case

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Rasmussen, Leif; Peña, Alfredo

    2013-01-01

    The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surf...... in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog....

  7. Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.

    Directory of Open Access Journals (Sweden)

    Thomas Vercruysse

    Full Text Available HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs. We have recently identified a llama single-domain antibody (Nb190 as the first inhibitor targeting the Rev multimerization function in cells. This nanobody is a potent intracellular antibody that efficiently inhibits HIV-1 viral production. In order to gain insight into the Nb190-Rev interaction interface, we performed mutational and docking studies to map the interface between the nanobody paratope and the Rev epitope. Alanine mutants of the hyper-variable domains of Nb190 and the Rev multimerization domains were evaluated in different assays measuring Nb190-Rev interaction or viral production. Seven residues within Nb190 and five Rev residues are demonstrated to be crucial for epitope recognition. These experimental data were used to perform docking experiments and map the Nb190-Rev structural interface. This Nb190-Rev interaction model can guide further studies of the Nb190 effect on HIV-1 Rev function and could serve as starting point for the rational development of smaller entities binding to the Nb190 epitope, aimed at interfering with protein-protein interactions of the Rev N-terminal domain.

  8. Play Therapy with Children in Crisis: Individual, Group, and Family Treatment. Third Edition

    Science.gov (United States)

    Webb, Nancy Boyd, Ed.

    2007-01-01

    Now in a completely revised and updated third edition, this widely adopted casebook and text presents effective, creative approaches to helping children who have experienced such stressful situations as parental death or divorce, abuse and neglect, violence in the school or community, and natural disasters. While the book retains the focus on…

  9. Teaching at Its Best: A Research-Based Resource for College Instructors. Second Edition.

    Science.gov (United States)

    Nilson, Linda B.

    This handbook is meant to be a toolbox, a compilation of hundreds of practical teaching techniques, formats, classroom activities, and exercises. This edition is revised and expanded to cover more about topics relevant to today's classroom, such as technology and the Internet. The 31 chapters are grouped into these sections: (1) "Sound…

  10. Meeting Special Educational Needs in Primary Classrooms: Inclusion and How to Do It. 2nd Edition

    Science.gov (United States)

    Briggs, Sue

    2016-01-01

    There are greater numbers of children with Special Educational Needs and Disabilities (SEND) now attending mainstream schools. This fully updated and revised edition of "Meeting Special Educational Needs in Primary Classrooms" is written by an experienced teacher, adviser and SEN consultant and explains the challenges that these children…

  11. Developing Cross-Cultural Competence: A Guide for Working with Children and Their Families. Fourth Edition

    Science.gov (United States)

    Lynch, Eleanor W., Ed.; Hanson, Marci J., Ed.

    2011-01-01

    As the U.S. population grows more and more diverse, how can professionals who work with young children and families deliver the best services while honoring different customs, beliefs, and values? The answers are in the fourth edition of this bestselling textbook, fully revised to reflect nearly a decade of population changes and best practices in…

  12. Online Training and Practice Manual for ERIC Data Base Searchers. 2nd Edition.

    Science.gov (United States)

    Markey, Karen; Cochrane, Pauline A.

    Revised to reflect changes in both DIALOG and ERIC, this second edition of a self-improvement manual for online searchers who wish to refine their skills presents three basic approaches to searching and provides illustrations from DIALOG's ERIC ONTAP database. The manual is divided into two parts: an 8-step model of the total search process which…

  13. Internet, Phone, Mail, and Mixed-Mode Surveys: The Tailored Design Method, 4th Edition

    Science.gov (United States)

    Dillman, Don A.; Smyth, Jolene D.; Christian, Lean Melani

    2014-01-01

    For over two decades, Dillman's classic text on survey design has aided both students and professionals in effectively planning and conducting mail, telephone, and, more recently, Internet surveys. The new edition is thoroughly updated and revised, and covers all aspects of survey research. It features expanded coverage of mobile phones, tablets,…

  14. Coping with Risk in Agriculture, 3rd edition : Applied Decision Analysis

    NARCIS (Netherlands)

    Hardaker, J.B.; Lien, G.; Anderson, J.R.; Huirne, R.

    2015-01-01

    Risk and uncertainty are inescapable factors in agriculture which require careful management. Farmers face production risks from the weather, crop and livestock performance, and pests and diseases, as well as institutional, personal and business risks. This revised third edition of this popular

  15. Educating Emergent Bilinguals: Policies, Programs, and Practices for English Learners. Second Edition. Language and Literacy Series

    Science.gov (United States)

    Garcia, Ofelia; Kleifgen, Jo Anne

    2018-01-01

    Now available in a revised and expanded edition, this accessible guide introduces readers to the issues and controversies surrounding the education of language minority students in the United States. What makes this book a perennial favorite are the succinct descriptions of alternative practices for transforming our schools and students' futures,…

  16. With this Special Edition

    Directory of Open Access Journals (Sweden)

    Oscar Antonio Martínez Molina

    2017-02-01

    Full Text Available With this Special Edition, the refereed Scientific Magazine, published in February 2017, presents a nourished and multidisciplinary theme, from the relationship of Environmental Education, in this ecological sharing man-environment; the social responsibility from the Management environment and the motivational values ​​conducive to the teaching performance in the different educational levels. Twenty-five (25 articles, generated from research production in university environments at the International level, are a signature of the quality of articles / essays presented in this Special Edition. Several reasons motivate the literary pen of our authors, adjusting to the rhythm of the times and the use of new technologies; and in correspondence with the care of the environment, this way of disseminating and making visible the scientific contents of humanistic and social court, support the care and protection of the forests, being an online production, in the Cloud. Thanks to the support of the Instituto Internacional de Investigación y Desarrollo Tecnológico Educativo INDTEC, CA, Scientific Magazine has been able to develop from the cooperative work of the people who compose its different committees: Editorial Academic Committee, Academic Scientific Committee and the Arbitrators in the review and valuation of the quality of the articles. With these assets, the Scientific Magazine, opening to the general public and especially to the academic new intellectual horizons.

  17. Natural Hazards, Second Edition

    Science.gov (United States)

    Rouhban, Badaoui

    Natural disaster loss is on the rise, and the vulnerability of the human and physical environment to the violent forces of nature is increasing. In many parts of the world, disasters caused by natural hazards such as earthquakes, floods, landslides, drought, wildfires, intense windstorms, tsunami, and volcanic eruptions have caused the loss of human lives, injury, homelessness, and the destruction of economic and social infrastructure. Over the last few years, there has been an increase in the occurrence, severity, and intensity of disasters, culminating with the devastating tsunami of 26 December 2004 in South East Asia.Natural hazards are often unexpected or uncontrollable natural events of varying magnitude. Understanding their mechanisms and assessing their distribution in time and space are necessary for refining risk mitigation measures. This second edition of Natural Hazards, (following a first edition published in 1991 by Cambridge University Press), written by Edward Bryant, associate dean of science at Wollongong University, Australia, grapples with this crucial issue, aspects of hazard prediction, and other issues. The book presents a comprehensive analysis of different categories of hazards of climatic and geological origin.

  18. Instrumental analysis, second edition

    International Nuclear Information System (INIS)

    Christian, G.D.; O'Reilly, J.E.

    1988-01-01

    The second edition of Instrumental Analysis is a survey of the major instrument-based methods of chemical analysis. It appears to be aimed at undergraduates but would be equally useful in a graduate course. The volume explores all of the classical quantitative methods and contains sections on techniques that usually are not included in a semester course in instrumentation (such as electron spectroscopy and the kinetic methods). Adequate coverage of all of the methods contained in this book would require several semesters of focused study. The 25 chapters were written by different authors, yet the style throughout the book is more uniform than in the earlier edition. With the exception of a two-chapter course in analog and digital circuits, the book purports to de-emphasize instrumentation, focusing more on the theory behind the methods and the application of the methods to analytical problems. However, a detailed analysis of the instruments used in each method is by no means absent. The book has the favor of a user's guide to analysis

  19. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  20. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Document Server

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  1. Diagnostic imaging of the hand. 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Schmitt, R.

    2004-01-01

    The second edition contains the following new features: Focus on cogenital, degenerative, inflammatory, tumourous, neurogenic and vascular diseases of the hands; new images of multiline spiral CT including 2D pictures and 3D reconstructions; new MRT images with examination protocols; synoptic presentation of all diseases according to their pathoanatomy, clinical symptoms, diagnostic imaging, differential diagnosis, therapeutic options; checklists for the doctor's everyday work. (orig.)

  2. 12MW Horns Rev experiment[Wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Hasager, C.B.; Pena, A; Mikkelsen, T.; Courtney, M.; Antoniou, I.; Gryning, S.-E.; Hansen, P. [Risoe National Lab., DTU, Wind Energy Dept. (Denmark); Soerensen, P.B. [DONG Energy (Denmark)

    2007-10-15

    The 12MW project with the full title '12 MW wind turbines: the scientific basis for their operation at 70 to 270 m height offshore' has the goal to experimentally investigate the wind and turbulence characteristics between 70 and 270 m above sea level and thereby establish the scientific basis relevant for the next generation of huge 12 MW wind turbines operating offshore. The report describes the experimental campaign at the Horns Rev offshore wind farm at which observations from Doppler Laser LIDAR and SODAR were collected from 3 May to 24 October 2006. The challenges for mounting and operating the instruments on the transformer platform at Horns Rev were overcome by a close collaboration between DONG energy and Risoe National Laboratory DTU. The site is presented. In particular, three tall offshore meteorological masts, up to 70 m tall, provided a useful source of meteorological data for comparison to the remotely sensed wind and turbulence observations. The comparison showed high correlation. The LIDAR and SODAR wind and turbulence observations were collected far beyond the height of the masts (up to 160 m above sea level) and the extended profiles were compared to the logarithmic wind profile. Further studies on this part of the work are on-going. Technical detail on LIDAR and SODAR are provided as well as theoretical work on turbulence and atmospheric boundary layer flow. Selected results from the experimental campaign are reported. (au)

  3. Wind Farm Wake: The 2016 Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Charlotte Bay Hasager

    2017-03-01

    Full Text Available Offshore wind farm wakes were observed and photographed in foggy conditions at Horns Rev 2 on 25 January 2016 at 12:45 UTC. These new images show highly contrasting conditions regarding the wind speed, turbulence intensity, atmospheric stability, weather conditions and wind farm wake development as compared to the Horns Rev 1 photographs from 12 February 2008. The paper examines the atmospheric conditions from satellite images, radiosondes, lidar and wind turbine data and compares the observations to results from atmospheric meso-scale modelling and large eddy simulation. Key findings are that a humid and warm air mass was advected from the southwest over cold sea and the dew-point temperature was such that cold-water advection fog formed in a shallow layer. The flow was stably stratified and the freestream wind speed was 13 m/s at hub height, which means that most turbines produced at or near rated power. The wind direction was southwesterly and long, narrow wakes persisted several rotor diameters downwind of the wind turbines. Eventually mixing of warm air from aloft dispersed the fog in the far wake region of the wind farm.

  4. rev piyasaları ve vergilendirilmesi

    OpenAIRE

    İşler, İsmail; Utku, Mehmet

    2015-01-01

    rev piyasaları kavramı, vadeli işlem sözleşmeleri (forward, futures), opsiyon sözleşmeleri, swap sözleşmeleri ve aracı kuruluş varantları işlemlerinin tamamını içermektedir. Bu tür işlemler vadeli işlemlerdir. Vadeli işlemlerin ortak özelliği, ilerideki bir tarihte teslimatı yapılmak üzere herhangi bir malın veya finansal aracın, bugünden alım satımının yapılmasıdır. Bu çalışmada türev araçların tanımları ve vergilendirilmeleri örneklerle açıklanacaktır. The term derivatives market invol...

  5. Contrast media. Safety issues and ESUR guidelines. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Thomsen, Henrik S. [Copenhagen University Hospital, Herlev (Denmark). Dept. of Diagnostic Radiology; Copenhagen Univ., Herlev (Denmark). Dept. of Diagnostic Sciences; Webb, Judith A.W. (eds.) [St. Bartholomew' s Hospital London Univ. (United Kingdom). Dept. of Radiology

    2009-07-01

    In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned members, reviewed the literature, proposed guidelines and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006. This second edition not only updates the previous edition, but also contains some completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues. Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are addressed, and the well-known ESUR guidelines on contrast media are included. This book, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media. (orig.)

  6. Contrast media. Safety issues and ESUR guidelines. 2. rev. ed.

    International Nuclear Information System (INIS)

    Thomsen, Henrik S.; Copenhagen Univ., Herlev; Webb, Judith A.W.

    2009-01-01

    In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned members, reviewed the literature, proposed guidelines and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006. This second edition not only updates the previous edition, but also contains some completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues. Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are addressed, and the well-known ESUR guidelines on contrast media are included. This book, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media. (orig.)

  7. Fundamentals of Welding. Teacher Edition [and] Student Edition [and] Student Workbook. Second Edition.

    Science.gov (United States)

    Fortney, Clarence; Gregory, Mike; New, Larry

    Teacher and student editions and a student workbook for fundamentals of welding comprise the first of six in a series of competency-based instructional materials for welding programs. Introductory pages in the teacher edition are training and competency profile, instructional/task analysis, basic skills icons and classifications, basic skills…

  8. Oxyacetylene Welding and Oxyfuel Cutting. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

    Science.gov (United States)

    Knapp, John; Harper, Eddie

    This Oklahoma curriculum guide, which includes a teacher edition, a student edition, and a student workbook, provides three units for a course on oxyacetylene welding, oxyfuel cutting, and cutting done with alternative fuels such as MAPP, propane, and natural gas. The three units are: "Oxyacetylene Welding"; "Oxyfuel Cutting";…

  9. Residential and Light Commercial HVAC. Teacher Edition and Student Edition. Second Edition.

    Science.gov (United States)

    Stephenson, David

    This package contains teacher and student editions of a residential and light commercial heating, ventilation, and air conditioning (HVAC) course of study. The teacher edition contains information on the following: using the publication; national competencies; competency profile; related academic and workplace skills list; tools, equipment, and…

  10. Volcanoes, Third Edition

    Science.gov (United States)

    Nye, Christopher J.

    It takes confidence to title a smallish book merely “Volcanoes” because of the impliction that the myriad facets of volcanism—chemistry, physics, geology, meteorology, hazard mitigation, and more—have been identified and addressed to some nontrivial level of detail. Robert and Barbara Decker have visited these different facets seamlessly in Volcanoes, Third Edition. The seamlessness comes from a broad overarching, interdisciplinary, professional understanding of volcanism combined with an exceptionally smooth translation of scientific jargon into plain language.The result is a book which will be informative to a very broad audience, from reasonably educated nongeologists (my mother loves it) to geology undergraduates through professional volcanologists. I bet that even the most senior professional volcanologists will learn at least a few things from this book and will find at least a few provocative discussions of subjects they know.

  11. Handbook of welding engineering. Vol. 1 and Vol. 2. 2. rev. ed.

    International Nuclear Information System (INIS)

    Ruge, J.

    1980-01-01

    This second edition of the handbook still has been guided by the principle of presenting as comprehensive information as possible on the whole subject field of welding engineering as concisely as seems adequate. The task of completely revising the first edition has not been restricted to up-dating the standards, guidelines and instruction sheets. It rather also seemed appropriate to amend the text in many cases in order to incorporate the latest results of research in science and technology. This inevitably enlarged the material to an extent recommending a publication in two volumes. Volume I deals with materials problems, and the sections discussing technical aspects of fracture mechanics and the welding of high-alloy steels have been enlarged. The section on nonmetals has been supplemented by a more detailed treatment of plastics and by chapters on other nonmetals such as glass, ceramics, graphite, and biological substances. Volume II deals with welding techniques, fabrication and quality assurance. Apart from the methods of welding, cutting, soldering, bonding (adhesives), and thermal spray coating, methods of improving the efficiency of fabrication by means of numerically controlled welding and process control are discussed in detail. Taking into account the growing importance of quality assurance, new chapters on modern control methods have been incorporated, methods such as control by neutron radiation, xeroradiography and acoustic and optical holography, as well as a section on distortion and buckling. The chapters on welding and cutting under water in marine technology, on occupational safety and economic aspects have been considerably enlarged. (orig./IHOE) [de

  12. Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection

    Science.gov (United States)

    Doria, Margherita; Neri, Francesca; Gallo, Angela; Farace, Maria Giulia; Michienzi, Alessandro

    2009-01-01

    Adenosine deaminases that act on dsRNA (ADARs) are enzymes that target double-stranded regions of RNA converting adenosines into inosines (A-to-I editing) thus contributing to genome complexity and fine regulation of gene expression. It has been described that a member of the ADAR family, ADAR1, can target viruses and affect their replication process. Here we report evidence showing that ADAR1 stimulates human immuno deficiency virus type 1 (HIV-1) replication by using both editing-dependent and editing-independent mechanisms. We show that over-expression of ADAR1 in HIV-1 producer cells increases viral protein accumulation in an editing-independent manner. Moreover, HIV-1 virions generated in the presence of over-expressed ADAR1 but not an editing-inactive ADAR1 mutant are released more efficiently and display enhanced infectivity, as demonstrated by challenge assays performed with T cell lines and primary CD4+ T lymphocytes. Finally, we report that ADAR1 associates with HIV-1 RNAs and edits adenosines in the 5′ untranslated region (UTR) and the Rev and Tat coding sequence. Overall these results suggest that HIV-1 has evolved mechanisms to take advantage of specific RNA editing activity of the host cell and disclose a stimulatory function of ADAR1 in the spread of HIV-1. PMID:19651874

  13. Loosening After Acetabular Revision

    DEFF Research Database (Denmark)

    Beckmann, Nicholas A.; Weiss, Stefan; Klotz, Matthias C.M.

    2014-01-01

    The best method of revision acetabular arthroplasty remains unclear. Consequently, we reviewed the literature on the treatment of revision acetabular arthroplasty using revision rings (1541 cases; mean follow-up (FU) 5.7 years) and Trabecular Metal, or TM, implants (1959 cases; mean FU 3.7 years...

  14. Explosive (chemical) substances. 6. rev. and enlarged ed. Explosivstoffe

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, R

    1985-01-01

    The sixth edition of this review manual again has been enlarged and actualized, the proved concept has been maintained. The text describes in large more than 550 items alphabetically, among them about 120 chemical compounds attributed with structure formulas and data. The properties, preparation procedures, and application possibilities of these substances and of about 70 additives, fuels and oxidants are presented for the reader. By nearly 1500 keywords in the index, English and French translations, and explanations of abbreviations, this book becomes a comprehensive and actual dictionary, not only for the specialist, but also for translators, interpreters, newspaper editors, and patent lawyers. (orig./HK).

  15. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee at its meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  16. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  17. Java2 Enterprise Edition 14 (J2EE 14) Bible

    CERN Document Server

    McGovern, James; Fain, Yakov; Gordon, Jason; Henry, Ethan; Hurst, Walter; Jain, Ashish; Little, Mark; Nagarajan, Vaidyanathan; Oak, Harshad; Phillips, Lee Anne

    2011-01-01

    Java 2 Enterprise Edition (J2EE) is the specification that all enterprise Java developers need to build multi-tier applications, and also the basis for BEA's WebLogic Application Server and IBM's WebSphereRevised to be current with the significant J2EE 1.4 update that will drive substantial developer interestWritten by a top-selling team of eleven experts who provide unique and substantial business examples in a vendor-neutral format, making the information applicable to various application serversCovers patterns, J2EE application servers, frameworks, Ant, and continuous availabilityIncludes e

  18. REV7, a new gene concerned with UV mutagenesis in yeast

    International Nuclear Information System (INIS)

    Lawrence, C.W.; Das, G.; Christensen, R.B.

    1985-01-01

    Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. Rev7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX. (orig.)

  19. REV7, a new gene concerned with UV mutagenesis in yeast

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, C.W.; Das, G.; Christensen, R.B.

    1985-06-26

    Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. REV7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX.

  20. NCCI Medically Unlikely Edits (MUEs)

    Data.gov (United States)

    U.S. Department of Health & Human Services — Medically Unlikely Edits (MUEs) define for each HCPCS / CPT code the maximum units of service (UOS) that a provider would report under most circumstances for a...

  1. Exercises in diagnostic radiology. Vol. 1. 4. rev. ed.

    International Nuclear Information System (INIS)

    Squire, L.F.; Colaiace, W.M.; Strutynsky, N.

    1983-01-01

    Intention of this book is to impart - by means of numerous exercises to be done - knowledge about radiology. It shall be used around the termination of the study of medicine, more or less in the sense of a self-test and supplement of the previous lectures and previously revised text books. The exercises of this first volume proceed from a certain knowledge about thorax radiology to be present. (orig./MG) [de

  2. Editörden Veda

    Directory of Open Access Journals (Sweden)

    Serpil Salaçin

    2000-04-01

    ştirenler. Kendine göre oıtak düşünce ve yürek ürünü olan dergiyi asılsız ve haksız yorumlayanlar. Ama tüm zorlukların üstesinden gelindiğini düşünüyorum. Bu nedenle benim kişisel olarak baştan beri üstlenmeyi düşündüğüm görevimin tamamlandığını düşünüyorum. Aşağıda bir kaç gün önce derneğimiz başkanlığına gönderdiğim görevden affım ile ilgili mektubu bu derneğin üyeleri olarak sizlerin de öğrenmeye hakkınız olduğunu düşünerek sizlerle paylaşmak istiyorum. Adli Tıp Uzmanları Derneği Başkanlığına, Sayın Prof. Dr. Gürsel Çetin, 26.03.2001 Derneğimizin kuruluşundan bu yana meslektaşlarımızın özverileri ile üretilenlere katkıda bulunmak hepimiz için görev olarak algılanıp yerine getirilmeye çalışıldı. Bu etkinlikler içinde bu alanın bilimsel üretimlerini paylaşabileceği, danışmanlı olarak çalışabilecek bir derginin oluşturulması fikri de derneğimizin bir etkinliğinde sizin de bildiğiniz koşullarda ortaya atıldı. Benimsendi. Bu üretimin gerçekleştirilmesinde görev verilenlerden de biri de bendim. Çıkarılacak derginin editörlük görevini bana vermiştiniz. Bana duyulan güvene ve verilmiş olan bu göreve teşekkür ediyorum. Adli Tıp Bülteni, ismi ile eldeki sınırlı olanaklarla rengi, kapağı, amblemi, formatı ile bir grup özverili arkadaşımızla birlikte doğdu. (ISSN 1300-865X kaydını aldı. Ben bu görevi bir meslek misyonu olarak gerçekleştirmeye çalıştım. Ulusal ve uluslar arası danışma kurulunun oluşturulmasında edindiğim uluslararası ilişkileri devreye sokarak bu kurulların zenginleştirilmesine çalıştım. Birlikte çalıştığımız arkadaşlarımızın her birinin özverileri ile dergi yazım kuralları, gelen makalelerin kaydı, danışmanlara gönderilmesi, danışman ve yazar arasındaki yazışmaların gerçekleştirilmesi, her sayının içeriği ve makale dışı yazı düzenlemeleri, sîzlerin de yakından bildiği bir

  3. [Preface for genome editing special issue].

    Science.gov (United States)

    Gu, Feng; Gao, Caixia

    2017-10-25

    Genome editing technology, as an innovative biotechnology, has been widely used for editing the genome from model organisms, animals, plants and microbes. CRISPR/Cas9-based genome editing technology shows its great value and potential in the dissection of functional genomics, improved breeding and genetic disease treatment. In the present special issue, the principle and application of genome editing techniques has been summarized. The advantages and disadvantages of the current genome editing technology and future prospects would also be highlighted.

  4. NRC comprehensive records disposition schedule. Revision 3

    International Nuclear Information System (INIS)

    1998-02-01

    Title 44 US Code, ''Public Printing and Documents,'' regulations issued by the General Service Administration (GSA) in 41 CFR Chapter 101, Subchapter B, ''Management and Use of Information and Records,'' and regulations issued by the National Archives and Records Administration (NARA) in 36 CFR Chapter 12, Subchapter B, ''Records Management,'' require each agency to prepare and issue a comprehensive records disposition schedule that contains the NARA approved records disposition schedules for records unique to the agency and contains the NARA's General Records Schedules for records common to several or all agencies. The approved records disposition schedules specify the appropriate duration of retention and the final disposition for records created or maintained by the NRC. NUREG-0910, Rev. 3, contains ''NRC's Comprehensive Records Disposition Schedule,'' and the original authorized approved citation numbers issued by NARA. Rev. 3 incorporates NARA approved changes and additions to the NRC schedules that have been implemented since the last revision dated March, 1992, reflects recent organizational changes implemented at the NRC, and includes the latest version of NARA's General Records Schedule (dated August 1995)

  5. NRC comprehensive records disposition schedule. Revision 3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    Title 44 US Code, ``Public Printing and Documents,`` regulations issued by the General Service Administration (GSA) in 41 CFR Chapter 101, Subchapter B, ``Management and Use of Information and Records,`` and regulations issued by the National Archives and Records Administration (NARA) in 36 CFR Chapter 12, Subchapter B, ``Records Management,`` require each agency to prepare and issue a comprehensive records disposition schedule that contains the NARA approved records disposition schedules for records unique to the agency and contains the NARA`s General Records Schedules for records common to several or all agencies. The approved records disposition schedules specify the appropriate duration of retention and the final disposition for records created or maintained by the NRC. NUREG-0910, Rev. 3, contains ``NRC`s Comprehensive Records Disposition Schedule,`` and the original authorized approved citation numbers issued by NARA. Rev. 3 incorporates NARA approved changes and additions to the NRC schedules that have been implemented since the last revision dated March, 1992, reflects recent organizational changes implemented at the NRC, and includes the latest version of NARA`s General Records Schedule (dated August 1995).

  6. Editörden

    OpenAIRE

    Toprakcı, Erdal

    2017-01-01

    Editörden 2017 yılının ikinci sayısıyla yeniden sizinleyiz. Kaliteye verdiğimiz önem sayesinde, çok kısa sürede adından söz ettiren bir dergiye dönüştük. Kuşkusuz bu süreçte en önemli etken yazarlarımız ve hakemlerimizin titizliğidir.Dergimizin bu sayısında şunlar var: Birinci olarak, YBO’da öğrenim gören öğrencilerin matematiğe yönelik genel tutumların olumlu olduğu, tutum puanlarının sınıf düzeyi, matematik başarısı, matematik öğretmeni sevme düzeyi, matematik önem algısı ve öz-yeterlik baş...

  7. Bones - joints - soft tissues II. 7. rev. ed. Knochen - Gelenke - Weichteile II

    Energy Technology Data Exchange (ETDEWEB)

    Dihlmann, W. (Roentgeninstitut, Allgemeines Krankenhaus Barmbek, Hamburg (Germany)); Frommhold, W. (Radiologische Klinik, Tuebingen Univ. (Germany)) (eds.)

    1991-01-01

    With the publication of the 2nd part to Volume VI, 'Bones - joints - soft tissues', the 7th edition of 'Diagnostic radiology in the hospital and medical practice' is complete. The advances made particularly during the past decade in the field of diagnostic radiology have made it neccesary for all the individual sections to be completely revised. Recently developed methods of imaging like sonography, computed tomography and magnetic resonance tomography are increasingly used as a replacement for or, at least, an adjunct to conventional X-ray procedures. Owing to the development and continuous refinement of related methods of intervention the gap between mere diagnostic applications and therapeutic uses of radiology could eventually be closed. The issues mainly discussed in this volume are bone fractures and healing, bone transplantation, osteopathy and osteoarthropathy, fibrous dyplasia or Albright's disease, Pagetoid osteitis, genetically transmitted constitutional disorders of the skeleton and soft tissue changes. While in the key sections on bone fractures and healing, osteopathy and osteoarthropathy as well as constitutional genetic disorders X-ray techniques are still described as the prevailing method of diagnosis, diseases of soft tissues now are much more commonly diagnosed using magnetic resonance imaging. (orig./MG) With 2248 figs., 59 tabs.

  8. Energy law. The legal boundary conditions of power supply. 2. rev. ed.

    International Nuclear Information System (INIS)

    Stuhlmacher, Gerd; Stappert, Holger; Jansen, Guido

    2015-01-01

    Now appearing in its second edition, this book presents a comprehensive overview of the legal framework governing the energy sector. It provides readily understandable coverage, across the relevant subfields of law, of the legal regulations applicable to any manner of activity in the energy sector along with a wealth of practical advice on the interpretation and application of legal provisions. The content has been thoroughly revised, updated to reflect the current status of legislation and supplemented with numerous chapters. The 2014 amendment of the Renewable Energy Law (EEG) and its practical impact have also been taken into account. The following topics are covered amongst others: unbundling of network operation; connection and access to networks and metering; network charges and incentive regulation; easement contracts; energy supply and basic services; energy and electricity taxes; cartel law, law on operating aids, procurement law; energy trade OTC and at exchanges; energy trade surveillance law; fuel production and fracking; conventional and nuclear power production; renewable energy production (including offshore production); energy storage and power-to-gas; transmission line construction; climate protection (including the 2014 EEG, emission trade and the Law on the Promotion of Renewable Energy in the Heat Sector); cogeneration law, district heating and contracting; and investment protection.

  9. Biogas plants in EEG. 4. new rev. and enl. ed.; Biogasanlagen im EEG

    Energy Technology Data Exchange (ETDEWEB)

    Loibl, Helmut; Maslaton, Martin; Bredow, Hartwig von; Walter, Rene (eds.)

    2016-08-01

    With the EEG 2014, the legislature has created a complete revision of all the RES plants. Specifically for biogas plants fundamental changes have been made with the maximum rated power or a new landscape conservation concept. For new biogas plants the legislator arranges not only a much lower remuneration, but also the direct marketing as a rule, which entails fundamental changes in the overall compensation system by itself. The new edition of this highly regarded standard work revives the extensive practical experience to EEG 2009, 2012 and 2014 in detail and in particular and takes into account the large number of newly issued clearinghouses decisions and judgments. All current legal issues and challenges of biogas plants can be found comprehensively presented here. [German] Mit dem EEG 2014 hat der Gesetzgeber eine komplette Neuregelung fuer alle EEG-Anlagen geschaffen. Speziell fuer Biogasanlagen wurden mit der Hoechstbemessungsleistung oder einem neuen Landschaftspflegebegriff grundlegende Aenderungen vorgenommen. Fuer neue Biogasanlagen ordnet der Gesetzgeber nicht nur eine deutlich geringere Verguetung, sondern zudem die Direktvermarktung als Regelfall an, was grundlegende Veraenderungen des gesamten Verguetungssystems nach sich zieht. Die Neuauflage dieses vielbeachteten Standardwerks greift die umfangreichen Praxiserfahrungen zum EEG 2009, 2012 und 2014 detailliert auf und beruecksichtigt insbesondere auch die Vielzahl der neu ergangenen Clearingstellenentscheidungen und Urteile. Alle aktuellen rechtlichen Themen und Herausforderungen bei Biogasanlagen finden Sie hier umfassend dargestellt.

  10. Stochastic processes in physics and chemistry. Revised and enlarged ed.

    International Nuclear Information System (INIS)

    Van Kampen, N.G.

    1992-01-01

    Three major changes have been made to this revised and updated edition. The Langevin equation receives more attention in a separate chapter in which non-Gaussian and colored noise are introduced. Another additional chapter contains old and new material on first-passage times and related subjects which lay the foundation for the chapter on unstable systems. Finally a completely new chapter has been written on the quantum mechanical foundations of noise. The references have also been expanded and updated

  11. Epistatic participation of REV1 and REV3 in the formation of UV-induced frameshift mutations in cell cycle-arrested yeast cells

    Energy Technology Data Exchange (ETDEWEB)

    Heidenreich, Erich [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)]. E-mail: erich.heidenreich@meduniwien.ac.at; Eisler, Herfried [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria); Steinboeck, Ferdinand [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)

    2006-01-29

    Mutations arising in times of cell cycle arrest may provide a selective advantage for unicellular organisms adapting to environmental changes. For multicellular organisms, however, they may pose a serious threat, in that such mutations in somatic cells contribute to carcinogenesis and ageing. The budding yeast Saccharomyces cerevisiae presents a convenient model system for studying the incidence and the mechanisms of stationary-phase mutation in a eukaryotic organism. Having studied the emergence of frameshift mutants after several days of starvation-induced cell cycle arrest, we previously reported that all (potentially error-prone) translesion synthesis (TLS) enzymes identified in S. cerevisiae did not contribute to the basal level of spontaneous stationary-phase mutations. However, we observed that an increased frequency of stationary-phase frameshift mutations, brought about by a defective nucleotide excision repair (NER) pathway or by UV irradiation, was dependent on Rev3p, the catalytic subunit of the TLS polymerase zeta (Pol {zeta}). Employing the same two conditions, we now examined the effect of deletions of the genes coding for polymerase eta (Pol {eta}) (RAD30) and Rev1p (REV1). In a NER-deficient strain background, the increased incidence of stationary-phase mutations was only moderately influenced by a lack of Pol {eta} but completely reduced to wild type level by a knockout of the REV1 gene. UV-induced stationary-phase mutations were abundant in wild type and rad30{delta} strains, but substantially reduced in a rev1{delta} as well as a rev3{delta} strain. The similarity of the rev1{delta} and the rev3{delta} phenotype and an epistatic relationship evident from experiments with a double-deficient strain suggests a participation of Rev1p and Rev3p in the same mutagenic pathway. Based on these results, we propose that the response of cell cycle-arrested cells to an excess of exo- or endogenously induced DNA damage includes a novel replication

  12. Quantum physics. 9. tot. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Gasiorowicz, S.

    2005-01-01

    This textbook belongs to the mostly favorite and illustrative introductions to quantum physics. The understandable way of presentation allows the independent access of the physical background of the world of quanta. Starting from the physical phenomena the book mediates the fundamental terms and procedures of quantum mechanics and illustrates them by means of extensive application examples and estimations of orders of magnitude. This proximity tro praxis gives to the book its aliveness. For the better understanding Gasiorowicz includes explaining steps and abandons complicated mathematical derivations. The discussion of the physical connections helps in the illustration of formal calculations. By this the successful transition from a course about modern physics to the purely formal development of quantum mechanics is possible. Numerous exercises are found in the extended part of problems. Furthermore the commented list of literature in the appendix is a valuable orientational aid for the study of quantum physics. The 9th edition was completely surveyed, actualized, and extended

  13. Contrast media in diagnostic radiology. 3. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Elke, M.; Gueckel, C.; Schmitt, H.E.; Felder, E.; Froehlich, J.M.; Radue, E.W.; Scheidegger, D.; Speck, U.

    1992-01-01

    With the 3rd edition of this book a comprehensive description is provided of all the properties and side-effects of contrast media as well as of the available remedies in mishaps caused by these agents. The individual chapters are headed as follows: (s. table of contents). 1. Introduction. 2. Contrast media for X-ray radiography, MRT, and ultrasonic scanning. 3. Kinetics of X-ray contrast media. 4. Pharamcodynamics of X-ray contrast media. 5. Side-effects of X-ray contrast media and complications encountered in practical radiology. 6. The mobile reanimation unit and the emergency kit. 7. Treatment of reactions to contrast media. 8. Appendix. 9. Bibliography, subject index. (orig./MG) With 25 figs., 5 text tabs., 39 tabs [de

  14. An introduction to magnetic resonance in medicine. 2. rev. ed.

    International Nuclear Information System (INIS)

    Rinck, P.A.; Muller, R.N.; Petersen, S.B.

    1990-01-01

    The second edition of this introduction to magnetic resonance in medicine is published five years after the first. During these years, magnetic resonance has established itself as a leading diagnostic modality in medicine. With the introduction of fast imaging methods and contrast agents, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have become even more complicated and complex than before. The purpose of this introduction to biomedical MRI and MRS is to give the readers a basic knowledge that will make it possible for them to pursue studies of their own and to cope with some of the most common problems such as image artifacts or patient questions concerning possible hazards of magnetic resonance. (orig./MG) With 99 figs., 11 tabs

  15. Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.

    Science.gov (United States)

    Han, Chang Woo; Jeong, Mi Suk; Jang, Se Bok

    2017-09-16

    Ras proteins are small GTPases that serve as master moderators of a large number of signaling pathways involved in various cellular processes. Activating mutations in Ras are found in about one-third of cancers. H-REV107, a K-Ras binding protein, plays an important role in determining K-Ras function. H-REV107 is a member of the HREV107 family of class II tumor suppressor genes and a growth inhibitory Ras target gene that suppresses cellular growth, differentiation, and apoptosis. Expression of H-REV107 was strongly reduced in about 50% of human carcinoma cell lines. However, the specific molecular mechanism by which H-REV107 inhibits Ras is still unknown. In the present study, we suggest that H-REV107 forms a strong complex with activating oncogenic mutation Q61H K-Ras from various biochemical binding assays and modeled structures. In addition, the interaction sites between K-Ras and H-REV107 were predicted based on homology modeling. Here, we found that some structure-based mutants of the K-Ras disrupted the complex formation with H-REV107. Finally, a novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Wind Farm Wake: The Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Pierre-Elouan Réthoré

    2013-02-01

    Full Text Available The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surface temperature as well as ground-based information at and near the wind farm, including Supervisory Control and Data Acquisition (SCADA data. The SCADA data reveal that the case of fog formation occurred 12 February 2008 on the 10:10 UTC. The fog formation is due to very special atmospheric conditions where a layer of cold humid air above a warmer sea surface re-condensates to fog in the wake of the turbines. The process is fed by warm humid air up-drafted from below in the counter-rotating swirl generated by the clock-wise rotating rotors. The condensation appears to take place primarily in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog.

  17. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3

    International Nuclear Information System (INIS)

    Kula, Anna; Gharu, Lavina; Marcello, Alessandro

    2013-01-01

    Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

  18. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan; Zhang, Eugene; Kobayashi, Yoshihiro; Wonka, Peter

    2011-01-01

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed highlevel operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques. © 2011 ACM.

  19. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan

    2011-12-12

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed highlevel operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques. © 2011 ACM.

  20. [Genome editing of industrial microorganism].

    Science.gov (United States)

    Zhu, Linjiang; Li, Qi

    2015-03-01

    Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

  1. Caffeine Abolishes the Ultraviolet-Induced REV3 Translesion Replication Pathway in Mouse Cells

    Directory of Open Access Journals (Sweden)

    Kouichi Yamada

    2011-11-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a photoproduct on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion. Using an alkaline sucrose density gradient sedimentation technique, we previously classified this process termed UV-induced translesion replication (UV-TLS into two types. In human cancer cells or xeroderma pigmentosum variant (XP-V cells, UV-TLS was inhibited by caffeine or proteasome inhibitors. However, in normal human cells, the process was insensitive to these reagents. Reportedly, in yeast or mammalian cells, REV3 protein (a catalytic subunit of DNA polymerase ζ is predominantly involved in the former type of TLS. Here, we studied UV-TLS in fibroblasts derived from the Rev3-knockout mouse embryo (Rev3KO-MEF. In the wild-type MEF, UV-TLS was slow (similar to that of human cancer cells or XP-V cells, and was abolished by caffeine or MG-262. In 2 cell lines of Rev3KO-MEF (Rev3−/− p53−/−, UV-TLS was not observed. In p53KO-MEF, which is a strict control for Rev3KO-MEF, the UV-TLS response was similar to that of the wild-type. Introduction of the Rev3 expression plasmid into Rev3KO-MEF restored the UV-TLS response in selected stable transformants. In some transformants, viability to UV was the same as that in the wild-type, and the death rate was increased by caffeine. Our findings indicate that REV3 is predominantly involved in UV-TLS in mouse cells, and that the REV3 translesion pathway is suppressed by caffeine or proteasome inhibitors.

  2. Mining the Human Complexome Database Identifies RBM14 as an XPO1-Associated Protein Involved in HIV-1 Rev Function

    OpenAIRE

    Budhiraja, Sona; Liu, Hongbing; Couturier, Jacob; Malovannaya, Anna; Qin, Jun; Lewis, Dorothy E.; Rice, Andrew P.

    2015-01-01

    By recruiting the host protein XPO1 (CRM1), the HIV-1 Rev protein mediates the nuclear export of incompletely spliced viral transcripts. We mined data from the recently described human nuclear complexome to identify a host protein, RBM14, which associates with XPO1 and Rev and is involved in Rev function. Using a Rev-dependent p24 reporter plasmid, we found that RBM14 depletion decreased Rev activity and Rev-mediated enhancement of the cytoplasmic levels of unspliced viral transcripts. RBM14 ...

  3. The physics and engineering aspects of radiology.. Textbook with questions and answers. 2. enl. and rev. ed.

    International Nuclear Information System (INIS)

    Link, T.M.; Heppe, A.

    1998-01-01

    The authors have chosen the form of questions and answers derived from practice in order to present and explain the fundamental physics and engineering aspects of radiology. The second, completely revised edition of the textbook has been updated so as to include recent legislation and the guidelines for specialized medical education and training for specialists in diagnostic radiology. One new chapters added deals with the diagnostic method of magnetic resonance imaging (MRI), and the chapters on computed tomography (CT), digital radiography and ultrasonography have been enlarged to include recent developments. The text is accompanied by illustrations that are easy to remember, showing the typical aspects and information, and the chapter containing and discussing diagnostic images has likewise been enlarged by representative CT and MRI images. The book is intended for readers preparing for their examination as specialists, for participants of courses in radiological protection, radiological medical technicians or medical students, and may also serve as a refresher course. (orig./CB) [de

  4. Verification of failure avoidance concepts in R6 Rev3

    International Nuclear Information System (INIS)

    Milne, I.; Knee, N.

    1988-09-01

    The first part of this Report outlines how recent developments in fracture mechanics have led to a more accurate interpretation of the two-criteria approach to defect assessment. The implementation of these developments into Revision 3 of the Central Electricity Generating Board code of practice for the assessment of the defect tolerance of structures (R6) is described. One of the key elements of the revised version is the recommendation that the failure assessment line should be derived from the actual tensile stress/strain properties of the material. The second part of the Report addresses the validation of the method, which is a crucial step on the way to obtaining acceptance of R6 by, in particular, the regulatory bodies. The range of structures used to validate the procedure is illustrated by two examples. The use of conservative data and assumptions is fundamental to the R6 philosophy, which means that the procedure should not be used as a predictive tool. In the second example the importance of making these conservative assumptions is clearly illustrated. (author)

  5. Comparative biomechanics: life's physical world (second edition)

    CERN Document Server

    Vogel, Steven

    2013-01-01

    Why do you switch from walking to running at a specific speed? Why do tall trees rarely blow over in high winds? And why does a spore ejected into air at seventy miles per hour travel only a fraction of an inch? Comparative Biomechanics is the first and only textbook that takes a comprehensive look at the mechanical aspects of life--covering animals and plants, structure and movement, and solids and fluids. An ideal entry point into the ways living creatures interact with their immediate physical world, this revised and updated edition examines how the forms and activities of animals and plants reflect the materials available to nature, considers rules for fluid flow and structural design, and explores how organisms contend with environmental forces. Drawing on physics and mechanical engineering, Steven Vogel looks at how animals swim and fly, modes of terrestrial locomotion, organism responses to winds and water currents, circulatory and suspension-feeding systems, and the relationship between size and mech...

  6. Boneless Pose Editing and Animation

    DEFF Research Database (Denmark)

    Bærentzen, Jakob Andreas; Hansen, Kristian Evers; Erleben, Kenny

    2007-01-01

    In this paper, we propose a pose editing and animation method for triangulated surfaces based on a user controlled partitioning of the model into deformable parts and rigid parts which are denoted handles. In our pose editing system, the user can sculpt a set of poses simply by transforming...... the handles for each pose. Using Laplacian editing, the deformable parts are deformed to match the handles. In our animation system the user can constrain one or several handles in order to define a new pose. New poses are interpolated from the examples poses, by solving a small non-linear optimization...... problem in order to obtain the interpolation weights. While the system can be used simply for building poses, it is also an animation system. The user can specify a path for a given constraint and the model is animated correspondingly....

  7. Tokamaks - Third Edition

    International Nuclear Information System (INIS)

    Rogister, A L

    2004-01-01

    John Wesson's well known book, now re-edited for the third time, provides an excellent introduction to fusion oriented plasma physics in tokamaks. The author's task was a very challenging one, for a confined plasma is a complex system characterised by a variety of dimensionless parameters and its properties change qualitatively when certain threshold values are reached in this multi-parameter space. As a consequence, theoretical description is required at different levels, which are complementary: particle orbits, kinetic and fluid descriptions, but also intuitive and empirical approaches. Theory must be carried out on many fronts: equilibrium, instabilities, heating, transport etc. Since the properties of the confined plasma depend on the boundary conditions, the physics of plasmas along open magnetic field lines and plasma surface interaction processes must also be accounted for. Those subjects (and others) are discussed in depth in chapters 2-9. Chapter 1 mostly deals with ignition requirements and the tokamak concept, while chapter 14 provides a list of useful relations: differential operators, collision times, characteristic lengths and frequencies, expressions for the neoclassical resistivity and heat conduction, the bootstrap current etc. The presentation is sufficiently broad and thorough that specialists within tokamak research can either pick useful and up-to-date information or find an authoritative introduction into other areas of the subject. It is also clear and concise so that it should provide an attractive and accurate initiation for those wishing to enter the field and for outsiders who would like to understand the concepts and be informed about the goals and challenges on the horizon. Validation of theoretical models requires adequately resolved experimental data for the various equilibrium profiles (clearly a challenge in the vicinity of transport barriers) and the fluctuations to which instabilities give rise. Chapter 10 is therefore devoted to

  8. Test Reviews: Reynolds, C., & Voress, J. K. (2007). "Test of Memory and Learning: Second Edition." Austin, TX: PRO-ED

    Science.gov (United States)

    Schmitt, Ara J.; Decker, Scott L.

    2009-01-01

    This article reviews the Test of Memory and Learning: Second Edition (TOMAL-2), published by PRO-ED, which constitutes a recent revision of the Test of Memory and Learning (TOMAL; Reynolds & Bigler, 1994). Advertised as the "single most comprehensive memory battery available for the entire age range of 5 years through 59 years of age", the TOMAL-2…

  9. How to Reach and Teach Children with ADD/ADHD: Practical Techniques, Strategies, and Interventions. Third Edition

    Science.gov (United States)

    Rief, Sandra F.

    2016-01-01

    The third edition of "How to Reach and Teach Children and Teens with ADD/ADHD" has been completely revised to offer the most updated and comprehensive guidance to everyone engaged in the positive education of children and teens who have been diagnosed with ADHD or show signs and symptoms of the disorder. This valuable resource contains…

  10. Correlations between the Stanford-Binet, 4th Edition, and the WISC-R with a Learning Disabled Population.

    Science.gov (United States)

    Phelps, LeAdelle; And Others

    1988-01-01

    Compared Stanford-Binet (Fourth Edition) and the Wechsler Intelligence Scale for Children-Revised as instruments for assessing the intellectual strengths and weaknesses of students (N=35) classified as learning disabled in elementary and secondary grades. Results suggest the tests will yield similar intelligence quotients for the learning disabled…

  11. Understanding Editing Behaviors in Multilingual Wikipedia.

    Directory of Open Access Journals (Sweden)

    Suin Kim

    Full Text Available Multilingualism is common offline, but we have a more limited understanding of the ways multilingualism is displayed online and the roles that multilinguals play in the spread of content between speakers of different languages. We take a computational approach to studying multilingualism using one of the largest user-generated content platforms, Wikipedia. We study multilingualism by collecting and analyzing a large dataset of the content written by multilingual editors of the English, German, and Spanish editions of Wikipedia. This dataset contains over two million paragraphs edited by over 15,000 multilingual users from July 8 to August 9, 2013. We analyze these multilingual editors in terms of their engagement, interests, and language proficiency in their primary and non-primary (secondary languages and find that the English edition of Wikipedia displays different dynamics from the Spanish and German editions. Users primarily editing the Spanish and German editions make more complex edits than users who edit these editions as a second language. In contrast, users editing the English edition as a second language make edits that are just as complex as the edits by users who primarily edit the English edition. In this way, English serves a special role bringing together content written by multilinguals from many language editions. Nonetheless, language remains a formidable hurdle to the spread of content: we find evidence for a complexity barrier whereby editors are less likely to edit complex content in a second language. In addition, we find that multilinguals are less engaged and show lower levels of language proficiency in their second languages. We also examine the topical interests of multilingual editors and find that there is no significant difference between primary and non-primary editors in each language.

  12. Understanding Editing Behaviors in Multilingual Wikipedia.

    Science.gov (United States)

    Kim, Suin; Park, Sungjoon; Hale, Scott A; Kim, Sooyoung; Byun, Jeongmin; Oh, Alice H

    2016-01-01

    Multilingualism is common offline, but we have a more limited understanding of the ways multilingualism is displayed online and the roles that multilinguals play in the spread of content between speakers of different languages. We take a computational approach to studying multilingualism using one of the largest user-generated content platforms, Wikipedia. We study multilingualism by collecting and analyzing a large dataset of the content written by multilingual editors of the English, German, and Spanish editions of Wikipedia. This dataset contains over two million paragraphs edited by over 15,000 multilingual users from July 8 to August 9, 2013. We analyze these multilingual editors in terms of their engagement, interests, and language proficiency in their primary and non-primary (secondary) languages and find that the English edition of Wikipedia displays different dynamics from the Spanish and German editions. Users primarily editing the Spanish and German editions make more complex edits than users who edit these editions as a second language. In contrast, users editing the English edition as a second language make edits that are just as complex as the edits by users who primarily edit the English edition. In this way, English serves a special role bringing together content written by multilinguals from many language editions. Nonetheless, language remains a formidable hurdle to the spread of content: we find evidence for a complexity barrier whereby editors are less likely to edit complex content in a second language. In addition, we find that multilinguals are less engaged and show lower levels of language proficiency in their second languages. We also examine the topical interests of multilingual editors and find that there is no significant difference between primary and non-primary editors in each language.

  13. Vieweg manual of motor car engineering. 3. tot. new rev. and enl. ed.; Vieweg Handbuch Kraftfahrzeugtechnik

    Energy Technology Data Exchange (ETDEWEB)

    Braess, H.H.; Seiffert, U. (eds.)

    2003-07-01

    This is the 3rd, revised and re-edited edition. Current trends are considered, i.e. DI and variable valve operation, particulate filters, double clutch gears, ESP-Plus, SUN-Fuel, and variable adaptive lighting. There are new chapters on standardisation (e.g. telematics and interface problems), accident research, internals, software, service-friendly design, maintenance and diagnosis, as well as sports and racing cars. Contents: Requirements on motor cars; Innovative technologies; Aerodynamics; Air conditioning; Acoustics; Design; Package; Fuel cell; Electric vehicles; Gas turbine; Spark ignition engine; Diesel engine; Superchargers; Couplings and gears; Four-wheel drives; Brakes and control systems; Two-stroke engines; Car bodies; Materials; Surface protection; Passenger compartment; Safety; Brakes; Tyres; Chassis; Fuels; Electric and electronic systems; Software; Driver assistant systems; Lighting; Sensors; Onboard network; EMP; Materials; Simultaneous engineering; Simulations; Experimental technologies; Motor cars and transportation in the future; Legislation and standardisation; Accident research; Diagnosis and maintenance; Racing cars and sports cars. [German] Fahrzeugingenieure in Praxis und Ausbildung benoetigen den raschen und sicheren Zugriff auf Grundlagen und Details der Fahrzeugtechnik sowie wesentliche zugehoerige industrielle Prozesse. Solche Informationen, die in ganz unterschiedlichen Quellen abgelegt sind, systematisch und bewertend zusammenzufuehren, hat sich dieses Handbuch zum Ziel gesetzt. Die Autoren sind bedeutende Fachleute der deutschen Automobil- und Zuliefererindustrie, sie stellen sicher, dass Theorie und Praxis vernetzt vermittelt werden. Die dritte Auflage wurde neu bearbeitet, aktualisiert und erweitert. Damit haben die aktuellen Entwicklungen von Benzindirekteinspritzung und variabler Ventilbetrieb, sowie Partikelfilter, Doppelkupplungsgetriebe, ESP-Plus, SUN-Fuel oder variable adaptive Beleuchtungssysteme Eingang gefunden. Neu

  14. Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells

    Energy Technology Data Exchange (ETDEWEB)

    Ramakrishnan, Sathiya N.; Lau, Patrick; Crowther, Lisa M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cleasby, Mark E. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Millard, Susan; Leong, Gary M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cooney, Gregory J. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Muscat, George E.O., E-mail: g.muscat@imb.uq.edu.au [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia)

    2009-10-30

    The nuclear hormone receptor, Rev-erb beta operates as a transcriptional silencer. We previously demonstrated that exogenous expression of Rev-erb{beta}{Delta}E in skeletal muscle cells increased Srebp-1c mRNA expression. We validated these in vitro observations by injection of an expression vector driving Rev-erb{beta}{Delta}E expression into mouse tibialis muscle that resulted in increased Srebp-1c mRNA expression. Paradoxically, Rev-erb{beta} siRNA expression in skeletal muscle cells repressed Srebp-1c expression, and indicated that Rev-erb{beta} expression was necessary for Srebp-1c expression. ChIP analysis demonstrated that Rev-erb{beta} was recruited to the Srebp-1c promoter. Moreover, Rev-erb{beta} trans-activated the Srebp-1c promoter, in contrast, Rev-erb{beta} efficiently repressed the Rev-erb{alpha} promoter, a previously characterized target gene. Finally, treatment with the Rev-erb agonist (hemin) (i) increased the trans-activation of the Srebp-1c promoter by Rev-erb{beta}; and (ii) increased Rev-erb{beta} and Srebp-1c mRNA expression. These data suggest that Rev-erb{beta} has the potential to activate gene expression, and is a positive regulator of Srebp-1c, a regulator of lipogenesis.

  15. German legislation for promotion of renewable energies 2014. Act on feed-in and guaranteed pricing of electricity from renewable energy sources (EEG). Commentary. 7. new rev. ed.

    International Nuclear Information System (INIS)

    Salje, Peter

    2015-01-01

    The EEG is continuously subjected to changes and the permanent center of political discussions. Therefore now already the 7th edition of the EEG comment of the science and practice well recognized and highly recognized author Prof. Dr. Dr. Peter Salje appear. The revision includes, inter alia, further evaluation of the law of electric power produced from renewable energy sources from the EEG of 2012 and the regulations made there under (including Biomass and AusglMechV). The changes associated with the so-called Photovoltaic amendment dated August 2012 and the recent case law since the publication of the previous edition handed down are considered. In particular, the incorporation of the full basic EEG reform in 2014 guarantees the highest topicality. [de

  16. Introducing ZBrush 3rd Edition

    CERN Document Server

    Keller, Eric

    2012-01-01

    Learn ZBrush inside and out with this updated new edition Get totally comfortable sculpting in a digital environment with the latest edition of this bestselling beginner's guide to ZBrush. Fully updated for the newest version of the software, ZBrush 4R3, this book dispels any fears you might have about the difficulty of using ZBrush and soon has you creating realistic, cartoon, and organic models with flair. Learn all the essentials, as you complete fun tutorials on painting, meshes, organic scripting, hard surface sculpting, lighting, rendering, and more. Introduces you to ZBrush, the sculpt

  17. Language Editing at Astronomy & Astrophysics

    Science.gov (United States)

    Adams, J.

    2011-07-01

    In 2002, the A&A Board of Directors voted that all articles must be written in English and decided to improve the overall quality of the language in the articles with the help of a team of language editors. This article reviews the general advantages of editing the English expression and describes both the aims of this effort and its place in the full publication process. This is followed by the Guide to language editing that has been available on the Journal's website for several years now.

  18. Beginning XML, 5th Edition

    CERN Document Server

    Fawcett, Joe; Quin, Liam R E

    2012-01-01

    A complete update covering the many advances to the XML language The XML language has become the standard for writing documents on the Internet and is constantly improving and evolving. This new edition covers all the many new XML-based technologies that have appeared since the previous edition four years ago, providing you with an up-to-date introductory guide and reference. Packed with real-world code examples, best practices, and in-depth coverage of the most important and relevant topics, this authoritative resource explores both the advantages and disadvantages of XML and addresses the mo

  19. Implementation of the 1996 edition of the IAEA regulations for the safe transport of radioactive material

    International Nuclear Information System (INIS)

    Rawl, R.R.; Kervella, O.

    1998-01-01

    The International Atomic Energy Agency (IAEA) completed a 10 year and revision of its 'Regulations for the Safe Transport of Radioactive Material' with approval of the amendments by its Board of Governors in September 1996. The revised edition contains some important changes in the regulations, including: type C package requirements; provisions for low dispersible material; uranium hexafluoride packaging; exemption value specifications; operational requirements, including the creation of a criticality safety index and new proper shipping names/UN numbers. The 1996 edition of the IAEA regulations has been published and corresponding revisions now being considered by the international transport safety organizations and Member States. In particular, the United Nations Committee of Experts on the Transport of Dangerous Goods, International Civil Aviation Organization and International Maritime Organization and preparing revisions to take into account the revised Class 7 requirements. An effective date of 1 January 2001 has been recommended so that international and domestic requirements might come into force simultaneously, thereby avoiding disruptive out-of-phase implementation. (authors)

  20. TEN YEARS OF THE NORTHEASTERN NURSING NETWORK JOURNAL - REV RENE: A DREAM COME TRUE

    Directory of Open Access Journals (Sweden)

    Inacia Sátiro Xavier de Franca

    2011-01-01

    Full Text Available Objetivou-se analisar a memória histórica da Rev Rene ao longo de uma década de sua existência destacando a sua organização, a produção científica e as conquistas alcançadas no concernente a sua indexação nas bases de dados. Estudo fenomenológico cujos dados foram coletados por meio de um formulário, submetidos a associações livres e interpretados em consonância com “A poética do espaço”. Os núcleos foram: Universidade Federal do Ceará (UFC — A casa da Rev Rene; A Rev Rene — ninho — um espaço aberto aos pesquisadores da Saúde e áreas afins; Poética das gavetas do cofre e dos armários — o capital científico da Rev Rene à disposição dos leitores; A Rev Rene — concha — uma homologia poética; A Rev Rene é redonda — Metas e ações para a projeção no cenário nacional e internacional. A Rev Rene transpôs a dimensão do sonho e consolidou-se como um lócus de ciência.

  1. Dictionary of agriculture. 5. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Haensch, G.; Haberkamp de Anton, G.

    1987-01-01

    The fifth edition of the 'Dictionary of Agriculture' has, like its predecessors, been set out in the proven and systematic way, namely according to linguistic subject matter. An alphabetical index in six languages and an additional index of Latin names and terms in current use means that the dictionary can be used as a technical dictionary as well as a systematic guide to terminology. Each term has been consecutively numbered throughout the systematic part of the dictionary. Since these numbers recur in every index, entries are both easy to find and easy to read. A natural selection had constantly to be made from the wealth of possible terms. Wherever possible, however, terms that are characteristic of a particular region have also been taken into account. The same is true of linguistic differences, e.g. between American and British English and between European and American Spanish as well as of regional peculiarities in language use in Germany, Austria, Switzerland, France and Belgium. Where popular plant names in addition to the scientific ones could not be ascertained - as was the case for Spanish, in particular - only the Latin names are listed, in accordance with general practice in Spanish specialist literature. (orig.) [de

  2. Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

    Directory of Open Access Journals (Sweden)

    Ryan D. Welch

    2017-07-01

    Conclusions: Disrupting Rev-Erb activity in injured muscle accelerates regenerative muscle repair/differentiation through transcriptional de-repression of myogenic programs. Rev-Erb, therefore, may be a potent therapeutic target for a myriad of muscular disorders.

  3. Edix: A Software for Editing Algebraic Expressions.

    OpenAIRE

    Bouhineau , Denis; Nicaud , Jean-François; Pavard , X.

    2001-01-01

    International audience; The paper presents a computer software, called Edix, devoted to the edition of algebraic expressions in their usual 2D representation. At present, many systems display fine algebraic expressions, but the edition of such expressions is weak. Systems like Word and FrameMaker place sub-expressions in too many boxes so that many editing actions are not simple, while usual CAS (computer algebra systems) just use a 1D representation for the edition. Furthermore, Edix allows ...

  4. Human Genome Editing and Ethical Considerations.

    Science.gov (United States)

    Krishan, Kewal; Kanchan, Tanuj; Singh, Bahadur

    2016-04-01

    Editing human germline genes may act as boon in some genetic and other disorders. Recent editing of the genome of the human embryo with the CRISPR/Cas9 editing tool generated a debate amongst top scientists of the world for the ethical considerations regarding its effect on the future generations. It needs to be seen as to what transformation human gene editing brings to humankind in the times to come.

  5. Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation

    Directory of Open Access Journals (Sweden)

    Jun Takezawa

    2010-01-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a lesion on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion, extend by a few nucleotides, and dissociate from the 3′-OH. The replicative polymerase then resumes DNA synthesis. This process, termed translesion replication (TLS or replicative bypass, may involve at least five different polymerases in mammals, although the participating polymerases and their roles have not been entirely characterized. Using siRNAs originally designed and an alkaline sucrose density gradient sedimentation technique, we verified the involvement of several polymerases in ultraviolet (UV light-induced TLS in HeLa cells. First, siRNAs to Rev3 or Rev7 largely abolished UV-TLS, suggesting that these 2 gene products, which comprise Polζ, play a main role in mutagenic TLS. Second, Rev1-targeted siRNA also abrogated UV-TLS, indicating that Rev1 is also indispensable to mutagenic TLS. Third, Polη-targeted siRNA also prevented TLS to a greater extent than our expectations. Forth, although siRNA to Polι had no detectable effect, that to Polκ delayed UV-TLS. To our knowledge, this is the first study reporting apparent evidence for the participation of Polκ in UV-TLS.

  6. Strategies of Qualitative Inquiry. Third Edition

    Science.gov (United States)

    Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

    2007-01-01

    "Strategies of Qualitative Inquiry, Third Edition," the second volume in the paperback version of "The SAGE Handbook of Qualitative Research, 3rd Edition," consists of Part III of the handbook ("Strategies of Inquiry"). "Strategies of Qualitative Inquiry, Third Edition" presents the major tactics--historically, the research methods--that…

  7. World Weather Extremes. Revision,

    Science.gov (United States)

    1985-12-01

    Ext r-,ncs, Weekl Weather and Crop Bull, Vol. 43, No. 9, pp. 6-8, 27 Feb 56. 21A. ntoli, La Piu Alta Temperatura del Mondo," [The HiLhest Temperi... Temperatura in Libia", Boll Soc Geogr Ita’iana, ser. 8, Vol. 7, pp. 59-71, 1954. 23J. Gentilli, "Libyan Climate", Geograph Rev, V0 l. 45, No. 2, p. 269 S" Apr

  8. Tea and cake [second edition

    OpenAIRE

    Wood, Philippa; MacLellan, Tamar

    2011-01-01

    Tea & Cake is an edited version of the original book produced by Philippa Wood in 2007. The book takes a nostalgic look at childhood memories of ‘baking with mother’ or special tea-time treats. The book combines ink-jet printing with typewritten text and rubber stamps; doilly end-papers and embroidered traycloth covers.

  9. Promoting School Success. Third Edition

    Science.gov (United States)

    Lovitt, Thomas C.

    2007-01-01

    Like its two predecessors, "Preventing School Dropouts" [C1991] and "Preventing School Failure" [C2000], this third edition is a book about teaching. Although primarily written for teachers, tutors and parents may also find this book helpful. It is a collection of carefully selected teaching techniques aimed at helping young adults learn important…

  10. Veterinary Microbiology, 3rd Edition

    Science.gov (United States)

    Veterinary Microbiology, Third Edition is organized into four sections and begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral d...

  11. Money and Schools. Fifth Edition

    Science.gov (United States)

    Thompson, David C.; Crampton, Faith E.; Wood, R. Craig

    2012-01-01

    In the new edition of this essential, all-inclusive text, the authors provide more important research for future principals and others enrolled in graduate-level school finance courses. Written in a style that is highly readable, the book offers strong connections to real-world experiences. Readers get both a broad overview of funding concepts and…

  12. Functional design criteria for project W-252, phase II liquid effluent treatment and disposal. Revision 2

    International Nuclear Information System (INIS)

    Hatch, C.E.

    1995-05-01

    This document is the Functional Design Criteria for Project W-252. Project W-252 provides the scope to provide BAT/AKART (best available technology...) to 200 Liquid Effluent Phase II streams (B-Plant). This revision (Rev. 2) incorporates a major descoping of the project. The descoping was done to reflect a combination of budget cutting measures allowed by a less stringent regulatory posture toward the Phase II streams

  13. Dictionary of minor planet names addendum to 6th edition 2012-2014

    CERN Document Server

    Schmadel, Lutz D

    2015-01-01

    The quantity of numbered minor planets is now approaching half a million. Together with this Addendum, the sixth edition of the Dictionary of Minor Planet Names, which is the IAU's official reference for the field, now covers more than 19,000 named minor planets. In addition to being of practical value for identification purposes, the Dictionary of Minor Planet Names provides authoritative information about the basis for the rich and colorful variety of ingenious names, from heavenly goddesses to artists, from scientists to Nobel laureates, from historical or political figures to ordinary women and men, from mountains to buildings, as well as a variety of compound terms and curiosities. This Addendum to the 6th edition of the Dictionary of Minor Planet Names adds approximately 2200 entries. It also contains many corrections, revisions and updates to the entries published in earlier editions. This work is an abundant source of information for anyone interested in minor planets and who enjoys reading about the ...

  14. 16th edition IEE wiring regulations design and verification of electrical installations

    CERN Document Server

    Scaddan, Brian

    1995-01-01

    This book builds on the basic knowledge and techniques covered in 16th Edition IEE Wiring Regulations Explained and Illustrated, providing the information and revision materials needed for the City & Guilds 2400 (Design, Erection and Verification ofElectrical Installations) exam. All Qualifying Managers will be required to gain this qualification, and Brian Scaddan's book is the ideal text for all students undertaking C&G 2400 courses.

  15. Maintenance manual. Vol. 1. Maintenance management; 2. completely rev. ed.; Handbuch Instandhaltung. Bd. 1. Instandhaltungsmanagement

    Energy Technology Data Exchange (ETDEWEB)

    Warnecke, H.J. [ed.] [Fraunhofer-Institut fuer Produktionstechnik und Automatisierung (IPA), Stuttgart (Germany)

    1992-12-31

    This manual is the second, completely revised edition of the standard manual ``Maintenance - Fundamentals``, which was first published in 1981. It presents an outline of all relevant fields of maintenance today and contains practical information on new and established methods of maintenance management and technology. With its comprehensive concept, which addresses any industrial enterprise that wants to remain competitive, the manual is indispensable for maintenance managers in industry, service enterprises and consultancies. Vol.1, ``Maintenance Management``, informs the reader on fundamentals, design with a view to maintenance, organisation of maintenance work, personnel management, industrial safety and economic aspects of maintenance. Current issues such as product liability, electronic data processing, expert systems, environmental protection, controlling based on characteristic data, etc. are gone into. Graphical representations, concrete procedural information and exemplary solutions may be used directly as working tools for the practice of maintenance. (orig.) [Deutsch] Das vorliegende Handbuch ist die zweite, voellig ueberarbeitete und erweiterte Auflage des Standardwerkes ``Instandhaltung - Grundlagen``, das 1981 erstmals erschien. Es gibt einen Ueberblick ueber alle relevanten Gebiete einer modernen Instandhaltung und vermittelt praxisnahes Wissen ueber neue und bewaehrte Methoden und Verfahren des Instandhaltungsmanagements und der Instandhaltungstechnik. Mit dieser umfassenden Konzeption, die auf die Belange des im Wettbewerb stehenden Industriebetriebes ausgerichtet ist, wendet sich das Handbuch an die Fuehrungskraefte der Instandhaltung in der Industrie sowie an Dienstleistungs- und Beratungsunternehmen. Im Band 1 ``Instandhaltungsmanagement`` kann sich der Leser ueber Grundlagen, instandhaltungsgerechtes Konstruieren, Organisation der Instandhaltung, Personalmanagement, Arbeitssicherheit sowie Wirtschaftlichkeit der Instandhaltung informieren

  16. Radiation Protection and Safety of Radiation Sources: International Basic Safety Standards. General Safety Requirements. Pt. 3 (Chinese Edition)

    International Nuclear Information System (INIS)

    2014-01-01

    This publication is the new edition of the International Basic Safety Standards. The edition is co-sponsored by seven other international organizations — European Commission (EC/Euratom), FAO, ILO, OECD/NEA, PAHO, UNEP and WHO. It replaces the interim edition that was published in November 2011 and the previous edition of the International Basic Safety Standards which was published in 1996. It has been extensively revised and updated to take account of the latest finding of the United Nations Scientific Committee on the Effects of Atomic Radiation, and the latest recommendations of the International Commission on Radiological Protection. The publication details the requirements for the protection of people and the environment from harmful effects of ionizing radiation and for the safety of radiation sources. All circumstances of radiation exposure are considered

  17. Radiation protection and safety of radiation sources: International basic safety standards. General safety requirements. Pt. 3 (French Edition)

    International Nuclear Information System (INIS)

    2016-01-01

    This publication is the new edition of the International Basic Safety Standards. The edition is co-sponsored by seven other international organizations — European Commission (EC/Euratom), FAO, ILO, OECD/NEA, PAHO, UNEP and WHO. It replaces the interim edition that was published in November 2011 and the previous edition of the International Basic Safety Standards which was published in 1996. It has been extensively revised and updated to take account of the latest finding of the United Nations Scientific Committee on the Effects of Atomic Radiation, and the latest recommendations of the International Commission on Radiological Protection. The publication details the requirements for the protection of people and the environment from harmful effects of ionizing radiation and for the safety of radiation sources. All circumstances of radiation exposure are considered

  18. Radiation Protection and Safety of Radiation Sources: International Basic Safety Standards. General Safety Requirements. Pt. 3 (Arabic Edition)

    International Nuclear Information System (INIS)

    2015-01-01

    This publication is the new edition of the International Basic Safety Standards. The edition is co-sponsored by seven other international organizations — European Commission (EC/Euratom), FAO, ILO, OECD/NEA, PAHO, UNEP and WHO. It replaces the interim edition that was published in November 2011 and the previous edition of the International Basic Safety Standards which was published in 1996. It has been extensively revised and updated to take account of the latest finding of the United Nations Scientific Committee on the Effects of Atomic Radiation, and the latest recommendations of the International Commission on Radiological Protection. The publication details the requirements for the protection of people and the environment from harmful effects of ionizing radiation and for the safety of radiation sources. All circumstances of radiation exposure are considered

  19. Test Methods for Evaluating Solid Waste, Physical/Chemical Methods. First Update. (3rd edition)

    International Nuclear Information System (INIS)

    Friedman; Sellers.

    1988-01-01

    The proposed Update is for Test Methods for Evaluating Solid Waste, Physical/Chemical Methods, SW-846, Third Edition. Attached to the report is a list of methods included in the proposed update indicating whether the method is a new method, a partially revised method, or a totally revised method. Do not discard or replace any of the current pages in the SW-846 manual until the proposed update I package is promulgated. Until promulgation of the update package, the methods in the update package are not officially part of the SW-846 manual and thus do not carry the status of EPA-approved methods. In addition to the proposed Update, six finalized methods are included for immediate inclusion into the Third Edition of SW-846. Four methods, originally proposed October 1, 1984, will be finalized in a soon to be released rulemaking. They are, however, being submitted to subscribers for the first time in the update. These methods are 7211, 7381, 7461, and 7951. Two other methods were finalized in the 2nd Edition of SW-846. They were inadvertantly omitted from the 3rd Edition and are not being proposed as new. These methods are 7081 and 7761

  20. Teede REV-2 otsustas börsile minna / Gea Velthut-Sokka

    Index Scriptorium Estoniae

    Velthut-Sokka, Gea, 1977-

    2004-01-01

    Eelmise aasta edukaima ehitusfirma Teede REV-2 ja tema suurinvestori Alta Kapital esindajad põhjendavad börsile mineku otsust. Tabelid ja diagrammid: Veerandi aktsiate omanikuvahetus börsilemineku peaprooviks

  1. REV ÜRÜNLERİN MUHASEBELEŞTİRİLMESİ

    OpenAIRE

    YURT, Eda

    2009-01-01

    Eda, Yurt, Türev Ürünlerin Muhasebelestirilmesi, Tezsiz Yüksek Lisans Dönem Projesi,Danısman: Doç. Dr. Kadir Gürdal, 58 s.BİTİRME PROJESİ ÖZETİProje finansal araçlar olarak türev ürünlerin muhasebelestirilmesine iliskinstandartların incelenmesini amaçlamaktadır. Öncelikle finansal risk tanımlanmıstır.Daha sonra türev piyasaların tarihi anlatılmıs ve islem gördükleri piyasalara göresınıflandırılmıstır. Bu temel açıklamalar sonrasında türev ürünler için UluslararasıMuhasebe Standartları incelen...

  2. The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes

    International Nuclear Information System (INIS)

    Fang Jianhua; Acheampong, Edward; Dave, Rajnish; Wang Fengxiang; Mukhtar, Muhammad; Pomerantz, Roger J.

    2005-01-01

    Productive infection by human immunodeficiency virus type I (HIV-1) in the central nervous system (CNS) involves mainly macrophages and microglial cells. A frequency of less than 10% of human astrocytes is estimated to be infectable with HIV-1. Nonetheless, this relatively low percentage of infected astrocytes, but associated with a large total number of astrocytic cells in the CNS, makes human astrocytes a critical part in the analyses of potential HIV-1 reservoirs in vivo. Investigations in astrocytic cell lines and primary human fetal astrocytes revealed that limited HIV-1 replication in these cells resulted from low-level viral entry, transcription, viral protein processing, and virion maturation. Of note, a low ratio of unspliced versus spliced HIV-1-specific RNA was also investigated, as Rev appeared to act aberrantly in astrocytes, via loss of nuclear and/or nucleolar localization and diminished Rev-mediated function. Host cellular machinery enabling Rev function has become critical for elucidation of diminished Rev activity, especially for those factors leading to RNA metabolism. We have recently identified a DEAD-box protein, DDX1, as a Rev cellular co-factor and now have explored its potential importance in astrocytes. Cells were infected with HIV-1 pseudotyped with envelope glycoproteins of amphotropic murine leukemia viruses (MLV). Semi-quantitative reverse transcriptase-polymerase chain reactions (RT-PCR) for unspliced, singly-spliced, and multiply-spliced RNA clearly showed a lower ratio of unspliced/singly-spliced over multiply-spliced HIV-1-specific RNA in human astrocytes as compared to Rev-permissive, non-glial control cells. As well, the cellular localization of Rev in astrocytes was cytoplasmically dominant as compared to that of Rev-permissive, non-glial controls. This endogenous level of DDX1 expression in astrocytes was demonstrated directly to lead to a shift of Rev sub-cellular distribution dominance from nuclear and/or nucleolar to

  3. Letter of Map Revision

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The National Flood Hazard Layer (NFHL) data incorporates all Digital Flood Insurance Rate Map(DFIRM) databases published by FEMA, and any Letters Of Map Revision...

  4. National Ignition Facility risk management plan, rev. 1

    International Nuclear Information System (INIS)

    Brereton, S J; Lane, M A

    1998-01-01

    The initial release of the National Ignition Facility (AUF) Risk Management Plan (LLNL, 1997a) was prepared in accordance with the DOE Life Cycle Asset Management Good Practice Guide (DOE, 1996a) and supported Critical Decision 3 (CD3), Approval to Initiate Construction (DOE, 1997a). The objectives of the plan were to: (1) Identify the risks to the completion of the Project in terms of meeting technical and regulatory requirements, cost, and schedule. (2) Assess the risks in terms of likelihood of occurrence and their impact potential relative to technical performance, ES and H (environmental, safety and health), costs, and schedule. (3) Address suitable risk mitigation measures for each identified risk. This revision of the Risk Management Plan considers project risks and vulnerabilities after CD3 (DOE, 1997a) was approved by the Secretary of Energy. During the one-year period since the initial release, the vulnerabilities of greatest concern have been the litigation of the Programmatic Environmental Impact Statement (PEIS) (DOE, 1996b) by a group of environmental organizations led by the Natural Resources Defense Council; the finding and successful clean-up of polychlorinated biphenyl (PCB)-filled electrical capacitors at the NIF site excavation; the FY98 congressional budget authorization and request for the FY99 budget authorization; funding for Inertial Confinement Fusion (ICF)/NIF programmatic activities (including French and other sources of funding); and finally, progress in the core science and technology, and optics program that form the basis for the NIF design

  5. Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation

    Science.gov (United States)

    Amador, Ariadna; Huitron-Resendiz, Salvador; Roberts, Amanda J.; Kamenecka, Theodore M.; Solt, Laura A.; Burris, Thomas P.

    2016-01-01

    The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery that regulates the circadian clock. The identical core clock machinery regulates myriad endocrine and metabolic functions providing a link between sleep and metabolic health. The REV-ERBs (REV-ERBα and REV-ERBβ) are nuclear receptors that are key regulators of the molecular clock and have been successfully targeted using small molecule ligands. Recent studies in mice suggest that REV-ERB-specific synthetic agonists modulate metabolic activity as well as alter sleep architecture, inducing wakefulness during the light period. Therefore, these small molecules represent unique tools to extensively study REV-ERB regulation of sleep and wakefulness. In these studies, our aim was to further investigate the therapeutic potential of targeting the REV-ERBs for regulation of sleep by characterizing efficacy, and optimal dosing time of the REV-ERB agonist SR9009 using electroencephalographic (EEG) recordings. Applying different experimental paradigms in mice, our studies establish that SR9009 does not lose efficacy when administered more than once a day, nor does tolerance develop when administered once a day over a three-day dosing regimen. Moreover, through use of a time response paradigm, we determined that although there is an optimal time for administration of SR9009 in terms of maximal efficacy, there is a 12-hour window in which SR9009 elicited a response. Our studies indicate that the REV-ERBs are potential therapeutic targets for treating sleep problems as those encountered as a consequence of shift work or jet lag. PMID:27603791

  6. Statistical Physics Approaches to RNA Editing

    Science.gov (United States)

    Bundschuh, Ralf

    2012-02-01

    The central dogma of molecular Biology states that DNA is transcribed base by base into RNA which is in turn translated into proteins. However, some organisms edit their RNA before translation by inserting, deleting, or substituting individual or short stretches of bases. In many instances the mechanisms by which an organism recognizes the positions at which to edit or by which it performs the actual editing are unknown. One model system that stands out by its very high rate of on average one out of 25 bases being edited are the Myxomycetes, a class of slime molds. In this talk we will show how the computational methods and concepts from statistical Physics can be used to analyze DNA and protein sequence data to predict editing sites in these slime molds and to guide experiments that identified previously unknown types of editing as well as the complete set of editing events in the slime mold Physarum polycephalum.

  7. Offshore wind farms in the local environment - an examination at Horns Rev Offshore Wind Farm. Background report; Havvindmoeller i lokalomraadet - en undersoegelse ved Horns Rev Havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, Susanne

    2005-07-01

    Horns Rev Offshore Wind Farm was built in 2002. A presentation is made of a sociological, qualitative survey on the local community's reception of the offshore wind farm. The survey aims at identifying attitudes towards the farm before and after the construction, with a view to identifying possible changes in attitudes, and explain the reasons for these (ml)

  8. The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency. Latest Status (Spanish Edition); Texto Revisado de Los Principios Rectores n Normas Generales de Ejecucion Para la Prestacion de Asistencia Tecnica por el Organismo

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1979-03-15

    The Revised Guiding Principles and General Operating Rules to Govern the Provision of Technical Assistance by the Agency were approved by the Board of Governors on 21 February 1979. The test is reproduced herein for the information of all Members. The provisions established by the Board of Governors on 24 September 1977 for the application of safeguards in relation to the granting of technical assistance are also reproduced in the Annex to the Revised Guiding Principles and General Operating Rules. [Spanish] El 21 de febrero de 1979 la Junta de Gobernadores aprobo el texto revisado de los Principios rectores y normas generales de ejecucion para la prestacion de asistencia tecnica por el Organismo. Para informacion de todos los Estados Miembros, en el presente documento se transcribe dicho texto. En el Anexo del texto revisado de los Principios rectores y normas generales de ejecucion se transcriben tambien las disposiciones prescritas por la Junta de Gobernadores el 24 de septiembre de 1977 acerca de la aplicacion de salvaguardias en relacion con la asistencia tecnica.

  9. Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking.

    Directory of Open Access Journals (Sweden)

    Min-Hsuan Lin

    Full Text Available Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. Here we investigate the mechanism of this effect for the first time, establishing that redistribution of Rev by Nullbasic is not due to direct interaction between the two proteins. Rather, Nullbasic affects subcellular localization of cellular proteins that regulate Rev trafficking. In particular, Nullbasic induced redistribution of exportin 1 (CRM1, nucleophosmin (B23 and nucleolin (C23 from the nucleolus to the nucleus when Rev was coexpressed, but never in its absence. Inhibition of the Rev:CRM1 interaction by leptomycin B or a non-interacting RevM10 mutant completely blocked redistribution of Rev by Nullbasic. Finally, Nullbasic did not inhibit importin β- or transportin 1-mediated nuclear import, suggesting that cytoplasmic accumulation of Rev was due to increased export by CRM1. Overall, our data support the conclusion that CRM1-dependent subcellular redistribution of Rev from the nucleolus by Nullbasic is not through general perturbation of either nuclear import or export. Rather, Nullbasic appears to interact with and disrupt specific components of a Rev trafficking complex required for its nucleocytoplasmic shuttling and, in particular, its nucleolar accumulation.

  10. 77 FR 65700 - Notice of Request for Comments on the Scope of Future Revisions to “Criteria for Preparation and...

    Science.gov (United States)

    2012-10-30

    ...: The Federal Emergency Management Agency (FEMA) is soliciting comments from stakeholders and interested... Regulatory Commission (NRC), is soliciting comments from stakeholders and interested members of the public on... revising NUREG-0654/ FEMA-REP-1, Rev.1 to address stakeholder interest and the various emergency planning...

  11. Interactive editing program using display

    International Nuclear Information System (INIS)

    Lang, I.; Ehsenski, J.; Namsraj, Yu.; Fefilov, B.V.

    1976-01-01

    A general description is given as well as principal functions are considered of 'DOSE' interactive editor program with a display involved. The program has been elaborated for TRA/1-1001 computer. This program enables one to edit and correct texts in algorithmical languages on a raster display screen as well as to provide perforated tapes for their further usage. 'DOSE' program is regarded as a basic program system for a set of TRA/1 and MINSK-32 computers

  12. Experimental Plan for EDF Energy Creep Rabbit Graphite Irradiations- Rev. 2 (replaces Rev. 0 ORNL/TM/2013/49).

    Energy Technology Data Exchange (ETDEWEB)

    Burchell, Timothy D [ORNL

    2014-07-01

    The experimental results obtained here will assist in the development and validation of future models of irradiation induced creep of graphite by providing the following data: Inert creep stain data from low to lifetime AGR fluence Inert creep-property data (especially CTE) from low to lifetime AGR fluence Effect of oxidation on creep modulus (by indirect comparison with experiment 1 and direct comparison with experiment 3 NB. Experiment 1 and 3 are not covered here) Data to develop a mechanistic understanding, including oAppropriate creep modulus (including pinning and high dose effects on structure) oInvestigation of CTE-creep strain behavior under inert conditions oInformation on the effect of applied stress/creep strain on crystallite orientation (requires XRD) oEffect of creep strain on micro-porosity (requires tomography & microscopy) This document describes the experimental work planned to meet the requirements of project technical specification [1] and EDF Energy requests for additional Pre-IE work. The PIE work is described in detail in this revision (Section 8 and 9).

  13. BOOK REVIEW: The Complete A-Z Physics Handbook, Second Edition

    Science.gov (United States)

    Breithaupt, Jim

    2000-11-01

    The first edition of this book was published in 1997 and reviewed in Physics Education in March 1988. This second edition is 13 pages longer and contains a significant number of new entries, mostly in particle physics and astrophysics, to match the latest AS/A-level specifications. Some entries on topics such as surface tension that were removed from previous AS/A-level syllabuses have now been deleted. The revised book thus provides an effective alphabetical guide to key terms used in the latest AS/A-level specifications as most AS/A-level core terms are included, apart from terms for some of the new topics such as image processing in the new IOP AS/A-level specification. The style of the second edition is the same as the first, each entry commencing with the key term in bold print followed by an explanation of the term, accompanied by the relevant equation and/or a simple diagram where appropriate. Cross-references are given in italics. For example, the entry under quarks (which is one of the new entries) lists the six quarks and their characteristic properties in bullet point format then follows up with the information about the quark composition of baryons and mesons, giving the composition of the proton, the neutron and the pions as examples. The change of quark composition due to beta decay is mentioned with a cross-reference to beta decay. Other cross-references link to entries on the proton, the neutron and the four fundamental interactions. Lengthy entries such as the photoelectric effect each cover several pages, thus providing opportunities for in-depth revision. Useful theme entries provided in the first edition have been retained and referred to in a new two-page appendix on preparing for synoptic questions. Some proofs are provided such as the proof of the kinetic theory equation. Some experiments are described, each under an appropriate entry. Technically, the entries are reasonably accurate and usually expressed in appropriate and familiar language

  14. New Testament Textual Criticism is dead! Long live New Testament ...

    African Journals Online (AJOL)

    p1243322

    HTS 63(2) 2007 scholarship taking Greek seriously, use the Greek New Testament texts of. Nestle-Aland, the latest being the 27th edition (NA 27) or that of the United. Bible Societies, the latest being the 4th revised edition (UBSGNT 4 rev or UBS4 rev ) and, except where it can help an argument, it seems that they generally.

  15. Particle Physics, 2nd Edition

    Science.gov (United States)

    Martin, B. R.; Shaw, G.

    1998-01-01

    Particle Physics, Second Edition is a concise and lucid account of the fundamental constituents of matter. The standard model of particle physics is developed carefully and systematically, without heavy mathematical formalism, to make this stimulating subject accessible to undergraduate students. Throughout, the emphasis is on the interpretation of experimental data in terms of the basic properties of quarks and leptons, and extensive use is made of symmetry principles and Feynman diagrams, which are introduced early in the book. The Second Edition brings the book fully up to date, including the discovery of the top quark and the search for the Higgs boson. A final short chapter is devoted to the continuing search for new physics beyond the standard model. Particle Physics, Second Edition features: * A carefully structured and written text to help students understand this exciting and demanding subject. * Many worked examples and problems to aid student learning. Hints for solving the problems are given in an Appendix. * Optional "starred" sections and appendices, containing more specialised and advanced material for the more ambitious reader.

  16. RNA Editing in Plant Mitochondria

    Science.gov (United States)

    Hiesel, Rudolf; Wissinger, Bernd; Schuster, Wolfgang; Brennicke, Axel

    1989-12-01

    Comparative sequence analysis of genomic and complementary DNA clones from several mitochondrial genes in the higher plant Oenothera revealed nucleotide sequence divergences between the genomic and the messenger RNA-derived sequences. These sequence alterations could be most easily explained by specific post-transcriptional nucleotide modifications. Most of the nucleotide exchanges in coding regions lead to altered codons in the mRNA that specify amino acids better conserved in evolution than those encoded by the genomic DNA. Several instances show that the genomic arginine codon CGG is edited in the mRNA to the tryptophan codon TGG in amino acid positions that are highly conserved as tryptophan in the homologous proteins of other species. This editing suggests that the standard genetic code is used in plant mitochondria and resolves the frequent coincidence of CGG codons and tryptophan in different plant species. The apparently frequent and non-species-specific equivalency of CGG and TGG codons in particular suggests that RNA editing is a common feature of all higher plant mitochondria.

  17. Edition des Corpus areopagiticum slavicum

    Directory of Open Access Journals (Sweden)

    Dieter Fahl

    2005-12-01

    Full Text Available An Edition of the Corpus areopagiticum slavicum In the fourteenth century, the monk Isaiah of the holy Mount Athos translated the writings of pseudo-Dionysius the Areopagite (c. end of the 5th century, core texts for Eastern and Western European theological and philosophical thought, from Greek into Church Slavonic. This first Slavic translation of Dionysius’ oeuvre (“De Coelesti Hierarchia,” “De Ecclesiastica Hierarchia,” “De Divinis Nominibus,” “De Mystica Theologia,” the epistles and scholia, which played a significant role in the development of Slavic culture, Orthodox Slavic socio-political theory and praxis, is still central to the study of Slavia Orthodoxa. A working group of German and Russian scholars has completed an edition of the translator’s Church Slavonic autograph with an en face reconstruction of the Greek text used by the translator and philological commentary. A Church Slavonic-Greek and Greek-Church Slavonic dictionary of this edition, currently in preparation, plans to make the terminology used in this influential translation accessible to interdisciplinary researchers. For the first time, the Church Slavonic lexica of this corpus, a substantial part of which was coined by the translator, will be registered in an index of words and forms.

  18. Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function

    Directory of Open Access Journals (Sweden)

    St-Laurent Georges

    2006-11-01

    Full Text Available Abstract Background The HIV Rev protein is known to facilitate export of incompletely spliced and unspliced viral transcripts to the cytoplasm, a necessary step in virus life cycle. The Rev-mediated nucleo-cytoplasmic transport of nascent viral transcripts, dependents on interaction of Rev with the RRE RNA structural element present in the target RNAs. The C-terminal variant of dsRNA-binding nuclear protein 90 (NF90ctv has been shown to markedly attenuate viral replication in stably transduced HIV-1 target cell line. Here we examined a mechanism of interference of viral life cycle involving Rev-NF90ctv interaction. Results Since Rev:RRE complex formations depend on protein:RNA and protein:protein interactions, we investigated whether the expression of NF90ctv might interfere with Rev-mediated export of RRE-containing transcripts. When HeLa cells expressed both NF90ctv and Rev protein, we observed that NF90ctv inhibited the Rev-mediated RNA transport. In particular, three regions of NF90ctv protein are involved in blocking Rev function. Moreover, interaction of NF90ctv with the RRE RNA resulted in the expression of a reporter protein coding sequences linked to the RRE structure. Moreover, Rev influenced the subcellular localization of NF90ctv, and this process is leptomycin B sensitive. Conclusion The dsRNA binding protein, NF90ctv competes with HIV Rev function at two levels, by competitive protein:protein interaction involving Rev binding to specific domains of NF90ctv, as well as by its binding to the RRE-RNA structure. Our results are consistent with a model of Rev-mediated HIV-1 RNA export that envisions Rev-multimerization, a process interrupted by NF90ctv.

  19. Nuclear Regulatory Commission Human Factors Program Plan. Revision 2

    International Nuclear Information System (INIS)

    1986-04-01

    This document is the Second Annual Revision to the NRC Human Factors Program Plan. The first edition was published in August 1983. Revision 1 was published in July of 1984. Purpose of the NRC Human Factors Program is to ensure that proper consideration is given to human factors in the design and operation of nuclear power plants. This document describes the plans of the Office of Nuclear Reactor Regulation to address high priority human factors concerns of importance to reactor safety in FY 1986 and FY 1987. Revision 2 of the plan incorporates recent Commission decisions and policies bearing on the human factors aspects of reactor safety regulation. With a few exceptions, the principal changes from prior editions reflect a shift from developing new requirements to staff evaluation of industry progress in resolving human factors issues. The plan addresses seven major program elements: (1) Training, (2) Licensing Examinations, (3) Procedures, (4) Man-Machine Interface, (5) Staffing and Qualifications, (6) Management and Organization, and (7) Human Performance

  20. Benchmarking in Thoracic Surgery. Third Edition.

    Science.gov (United States)

    Freixinet Gilart, Jorge; Varela Simó, Gonzalo; Rodríguez Suárez, Pedro; Embún Flor, Raúl; Rivas de Andrés, Juan José; de la Torre Bravos, Mercedes; Molins López-Rodó, Laureano; Pac Ferrer, Joaquín; Izquierdo Elena, José Miguel; Baschwitz, Benno; López de Castro, Pedro E; Fibla Alfara, Juan José; Hernando Trancho, Florentino; Carvajal Carrasco, Ángel; Canalís Arrayás, Emili; Salvatierra Velázquez, Ángel; Canela Cardona, Mercedes; Torres Lanzas, Juan; Moreno Mata, Nicolás

    2016-04-01

    Benchmarking entails continuous comparison of efficacy and quality among products and activities, with the primary objective of achieving excellence. To analyze the results of benchmarking performed in 2013 on clinical practices undertaken in 2012 in 17 Spanish thoracic surgery units. Study data were obtained from the basic minimum data set for hospitalization, registered in 2012. Data from hospital discharge reports were submitted by the participating groups, but staff from the corresponding departments did not intervene in data collection. Study cases all involved hospital discharges recorded in the participating sites. Episodes included were respiratory surgery (Major Diagnostic Category 04, Surgery), and those of the thoracic surgery unit. Cases were labelled using codes from the International Classification of Diseases, 9th revision, Clinical Modification. The refined diagnosis-related groups classification was used to evaluate differences in severity and complexity of cases. General parameters (number of cases, mean stay, complications, readmissions, mortality, and activity) varied widely among the participating groups. Specific interventions (lobectomy, pneumonectomy, atypical resections, and treatment of pneumothorax) also varied widely. As in previous editions, practices among participating groups varied considerably. Some areas for improvement emerge: admission processes need to be standardized to avoid urgent admissions and to improve pre-operative care; hospital discharges should be streamlined and discharge reports improved by including all procedures and complications. Some units have parameters which deviate excessively from the norm, and these sites need to review their processes in depth. Coding of diagnoses and comorbidities is another area where improvement is needed. Copyright © 2015 SEPAR. Published by Elsevier Espana. All rights reserved.

  1. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

    Directory of Open Access Journals (Sweden)

    Gwendal Le Martelot

    2009-09-01

    Full Text Available In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coordinated by the circadian timing system. Molecular clocks are thought to rely on negative feedback loops in clock gene expression that engender oscillations in the accumulation of transcriptional regulatory proteins, such as the orphan receptor REV-ERBalpha. Circadian transcription factors then drive daily rhythms in the expression of clock-controlled output genes, for example genes encoding enzymes and regulators of cellular metabolism. To gain insight into clock output functions of REV-ERBalpha, we carried out genome-wide transcriptome profiling experiments with liver RNA from wild-type mice, Rev-erbalpha knock-out mice, or REV-ERBalpha overexpressing mice. On the basis of these genetic loss- and gain-of-function experiments, we concluded that REV-ERBalpha participates in the circadian modulation of sterol regulatory element-binding protein (SREBP activity, and thereby in the daily expression of SREBP target genes involved in cholesterol and lipid metabolism. This control is exerted via the cyclic transcription of Insig2, encoding a trans-membrane protein that sequesters SREBP proteins to the endoplasmic reticulum membranes and thereby interferes with the proteolytic activation of SREBPs in Golgi membranes. REV-ERBalpha also participates in the cyclic expression of cholesterol-7alpha-hydroxylase (CYP7A1, the rate-limiting enzyme in converting cholesterol to bile acids. Our findings suggest that this control acts via the stimulation of LXR nuclear receptors by cyclically produced oxysterols. In conclusion, our study suggests that rhythmic cholesterol and bile acid metabolism is not just driven by alternating feeding-fasting cycles, but also by REV-ERBalpha, a component of the circadian clockwork circuitry.

  2. Acetabular Cup Revision.

    Science.gov (United States)

    Kim, Young-Ho

    2017-09-01

    The use of acetabular cup revision arthroplasty is on the rise as demands for total hip arthroplasty, improved life expectancies, and the need for individual activity increase. For an acetabular cup revision to be successful, the cup should gain stable fixation within the remaining supportive bone of the acetabulum. Since the patient's remaining supportive acetabular bone stock plays an important role in the success of revision, accurate classification of the degree of acetabular bone defect is necessary. The Paprosky classification system is most commonly used when determining the location and degree of acetabular bone loss. Common treatment options include: acetabular liner exchange, high hip center, oblong cup, trabecular metal cup with augment, bipolar cup, bulk structural graft, cemented cup, uncemented cup including jumbo cup, acetabular reinforcement device (cage), trabecular metal cup cage. The optimal treatment option is dependent upon the degree of the discontinuity, the amount of available bone stock and the likelihood of achieving stable fixation upon supportive host bone. To achieve successful acetabular cup revision, accurate evaluation of bone defect preoperatively and intraoperatively, proper choice of method of acetabular revision according to the evaluation of acetabular bone deficiency, proper technique to get primary stability of implant such as precise grafting technique, and stable fixation of implant are mandatory.

  3. The Sport Concussion Assessment Tool 5th Edition (SCAT5): Background and rationale.

    Science.gov (United States)

    Echemendia, Ruben J; Meeuwisse, Willem; McCrory, Paul; Davis, Gavin A; Putukian, Margot; Leddy, John; Makdissi, Michael; Sullivan, S John; Broglio, Steven P; Raftery, Martin; Schneider, Kathryn; Kissick, James; McCrea, Michael; Dvořák, Jiří; Sills, Allen K; Aubry, Mark; Engebretsen, Lars; Loosemore, Mike; Fuller, Gordon; Kutcher, Jeffrey; Ellenbogen, Richard; Guskiewicz, Kevin; Patricios, Jon; Herring, Stanley

    2017-06-01

    This paper presents the Sport Concussion Assessment Tool 5th Edition (SCAT5), which is the most recent revision of a sport concussion evaluation tool for use by healthcare professionals in the acute evaluation of suspected concussion. The revision of the SCAT3 (first published in 2013) culminated in the SCAT5. The revision was based on a systematic review and synthesis of current research, public input and expert panel review as part of the 5th International Consensus Conference on Concussion in Sport held in Berlin in 2016. The SCAT5 is intended for use in those who are 13 years of age or older. The Child SCAT5 is a tool for those aged 5-12 years, which is discussed elsewhere. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. X-ray anatomy - radiological imaging, radiation protection. For auxiliary medical personnel, technicians, physicists. 3. rev. and enlarged ed. Roentgenanatomie - radiologische Darstellung, Strahlenschutz. Fuer aerztliches Hilfspersonal, Techniker, Physiker

    Energy Technology Data Exchange (ETDEWEB)

    Frik, W; Goering, U

    1988-01-01

    This third edition as the result of a complete revision of the second edition reflects the current state of the art and includes topical information on a variety of advances hitherto achieved, as for instance information on novel imaging techniques in diagnostic radiology that have been included in the chapters on physical fundamentals or examination methods, as well as in all chapters discussing the anatomy and the relevant radiological imaging methods. As practice has shown that the application of the latest standards on radiation doses and units still poses problems, the authors decided to add a section explaining dose concepts, terminology and units. The two chapters dealing with contrast media and with radiological examination methods have been updated and supplemented. The anatomy chapters, written for readers who are not doctors, and the survey of the relevant diagnostic radiology still form the core of the book, but all in all this third edition now puts equal emphasis on all three aspects concerned, namely X-ray anatomy, radiological imaging, and radiation protection. (orig./MG) With 96 figs.

  5. C14-Crash. The C14-method and dendrochronology, unveiling the illusion. 2. rev. ed.

    International Nuclear Information System (INIS)

    Bloess, C.; Niemitz, H.U.

    2000-01-01

    In this second edition of the book, which was published almost three years after the first edition, the authors reiterate and substantiate their doubts as to the basic theories underlying the radiocarbon dating method and the applicability of dendrochronology. (orig/CB) [de

  6. Learn, Grow, Become. TSA Edition.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This revised curriculum guide contains five units that are designed to help students develop an understanding of the mission of the Technology Student Association (TSA). Each unit follows a standard format that includes some or all of these basic components: performance objectives, suggested activities, handouts, information sheets, supplements,…

  7. Intellectual Freedom Manual. Eighth Edition

    Science.gov (United States)

    ALA Editions, 2010

    2010-01-01

    Updated for the first time since 2005, this indispensable volume includes revised interpretations of the Library Bill of Rights along with key intellectual freedom guidelines and policies, including: (1) A new chapter, "Interactivity and the Internet," and other fresh material on intellectual freedom and privacy in online social…

  8. The continuous review and periodic revision process for the International Atomic Energy Agencies regulations for the safe transport of radioactive materials - A status report

    International Nuclear Information System (INIS)

    O'Sullivan, R.A.; Pettersson, B.G.; Pope, R.B.

    1989-01-01

    The International Atomic Energy Agencies (IAEA) Regulations for the Safe Transport of Radioactive Material, Safety Series No.6 (hereinafter denoted as the Regulations) have developed into the model for international modal organization and individual country regulations (and other regulatory-related documentation) controlling the packaging and transportation of radioactive materials. The Regulations were initially developed in 1961 and have been periodically revised since then. Revised editions of the Regulations, accounting for developments in technology and shipping practices, were issued in 1965, 1967, 1973 (also, an amended 1973 Edition was issued in 1979), and in 1985. The process of developing these documents has been performed on a cooperative basis utilizing inputs from various member states of the IAEA and from other interested international organizations. The latest comprehensive revision of the Regulations and its supportive documents was initiated in 1979, and culminated in the 1985 Edition of the Regulations. This was the first complete revision to be published since 1973 (except for the amended Edition thereto being issued in 1979). During the process which led to the 1985 Edition of the Regulations and its supportive documents, it became apparent that changes needed to be made in this process. Not addressing issues related to transportation regulations on a continuing basis created many difficulties in trying to efficiently and acceptably review and revise these documents in a short period of time. The purpose of this paper is to outline the review/revision process which was established, to summarize the results from that process so far (in terms of changes that have been made to the 1985 Edition through supplements thereto), and to discuss current plans for carrying on with the review/revision process with slight modifications

  9. Connectivity editing for quad-dominant meshes

    KAUST Repository

    Peng, Chihan

    2013-08-01

    We propose a connectivity editing framework for quad-dominant meshes. In our framework, the user can edit the mesh connectivity to control the location, type, and number of irregular vertices (with more or fewer than four neighbors) and irregular faces (non-quads). We provide a theoretical analysis of the problem, discuss what edits are possible and impossible, and describe how to implement an editing framework that realizes all possible editing operations. In the results, we show example edits and illustrate the advantages and disadvantages of different strategies for quad-dominant mesh design. © 2013 The Author(s) Computer Graphics Forum © 2013 The Eurographics Association and John Wiley & Sons Ltd.

  10. Contributions of individual domains to function of the HIV-1 Rev response element.

    Science.gov (United States)

    O'Carroll, Ina P; Thappeta, Yashna; Fan, Lixin; Ramirez-Valdez, Edric A; Smith, Sean; Wang, Yun-Xing; Rein, Alan

    2017-08-16

    The HIV-1 Rev response element (RRE) is a 351-base element in unspliced and partially spliced viral RNA; binding of the RRE by the viral Rev protein induces nuclear export of RRE-containing RNAs, as required for virus replication. It contains one long, imperfect double helix (domain I), one branched domain (domain II) containing a high-affinity Rev-binding site, and two or three additional domains. We previously reported that the RRE assumes an "A" shape in solution and suggested that the location of the Rev binding sites in domains I and II, opposite each other on the two legs of the A, is optimal for Rev binding and explains Rev's specificity for RRE-containing RNAs. Using SAXS and a quantitative functional assay, we have now analyzed a panel of RRE mutants. All the results support the essential role of the A shape for RRE function. Moreover, they suggest that the distal portion of domain I and the three crowning domains all contribute to the maintenance of the A shape. Domains I and II are necessary and sufficient for substantial RRE function, provided they are joined by a flexible linker that allows the two domains to face each other. IMPORTANCE Retroviral replication requires that some of the viral RNAs transcribed in the cell nucleus be exported to the cytoplasm without being spliced. To achieve this, HIV-1 encodes a protein, Rev, which binds to a complex, highly structured element within viral RNA, the Rev Response Element (RRE), and escorts RRE-containing RNAs from the nucleus. We previously reported that the RRE is "A"-shaped and suggested that this architecture, with the 2 legs opposite one another, can explain the specificity of Rev for the RRE. We have analyzed the functional contributions of individual RRE domains, and now report that several domains contribute, with some redundancy, to maintenance of the overall RRE shape. The data strongly support the hypothesis that the opposed placement of the 2 legs is essential for RRE function. Copyright © 2017

  11. Environmental Radioactivity from Natural, Industrial and Military Sources. 4th Edition

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Steve

    1998-09-01

    Merril Eisenbud's series of books on environmental radioactivity have long had a place on the bookshelves of those involved with the environmental aspects of radiation protection. They provide authoritative coverage of the subject including sources, transport mechanisms and effects. The first edition, published in 1963, was naturally mostly concerned with the effects of nuclear weapons testing in the atmosphere. The second edition, published in 1977, reflected the then expansive phase of nuclear power development worldwide and included an extensive treatment of the nuclear fuel cycle and its contributions to environmental radioactivity. In 1987 the third edition included coverage of the Three Mile Island accident and the Chernobyl accident against the background of cessation of new orders for nuclear plant in the United States. The fourth edition is a major revision with a lot of new material, and the welcome adoption of SI units throughout. The principal additions to the new edition are chapters on environmental surveillance, radiological assessment and dose reconstruction, and the remediation of contaminated sites; nothing has been lost from the extensive coverage of other topics in the third edition, whilst the text and bibliography have been revised and brought up to date. Earlier editions of the book have provided good summaries of accidents which have resulted in environmental contamination, and the updating here results in more extensive and up-to-date coverage of the Three Mile Island and Chernobyl accidents, including the more recent evidence of health effects from the latter, together with new sections on the Palomares nuclear weapons accident in Spain, the Mayak/Chelyabinsk complex in Russia, and the accidents involving lost gamma radiation sources in Juarez, Mexico and Goiania, Brazil. Both here and in the extensive coverage of contamination at the USDoE production sites the new edition reflects and benefits from the increased public availability

  12. Government Contract Law (9th Edition)

    Science.gov (United States)

    1987-04-01

    This Ninth Edition, like its predecessors, will serve as the textbook for the Government Contract Law taught at the School of Systems and Logistics...drawn from Government Contract Law -Cases, 1987 edition, for a rounded approach to the subject. This edition of the text includes coverage of the...Government Contract Law complements the Federal Acquisition Regulation and provides a preventive law treatment for contracting personnel. While it may

  13. Operational Transformation In Co-Operative Editing

    Directory of Open Access Journals (Sweden)

    Mandeep Kaur

    2015-08-01

    Full Text Available Cooperative Editing Systems in real-time allows a virtual team to view and edit a shared document at the same time. The document shared must be synchronized in order to ensure consistency for all the participants. This paper describes the Operational Transformation the evolution of its techniques its various applications major issues and achievements. In addition this paper will present working of a platform where two users can edit a code programming file at the same time.

  14. B23/nucleophosmin interacts with bovine immunodeficiency virus Rev protein and facilitates viral replication.

    Science.gov (United States)

    Passos-Castilho, Ana Maria; Marchand, Claude; Archambault, Denis

    2018-02-01

    The bovine immunodeficiency virus (BIV) Rev shuttling protein contains nuclear/nucleolar localization signals and nuclear import/export mechanisms that are novel among lentivirus Rev proteins. Several viral proteins localize to the nucleolus, which may play a role in processes that are essential to the outcome of viral replication. Although BIV Rev localizes to the nucleoli of transfected/infected cells and colocalizes with one of its major proteins, nucleophosmin (NPM1, also known as B23), the role of the nucleolus and B23 in BIV replication remains to be determined. Here, we demonstrate for the first time that BIV Rev interacts with nucleolar phosphoprotein B23 in cells. Using small interfering RNA (siRNA) technology, we show that depletion of B23 expression inhibits virus production by BIV-infected cells, indicating that B23 plays an important role in BIV replication. The interaction between Rev and B23 may represent a potential new target for the development of antiviral drugs against lentiviruses. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. SEM-REV: A sea test site for Marine Energy Converter

    International Nuclear Information System (INIS)

    Berhault, Christian; Le Crom, Izan; Le Bihan, Gerard

    2015-01-01

    Thanks to a main funding of Region des Pays de la Loire, the sea test site SEM-REV has been developed by Ecole Centrale de Nantes since 2007 to test both Wave Energy Converters and Floating Wind Turbine in real sea conditions. The sea test site is equipped with a set of oceanographic sensors and with an electric cable of 8 MW, connected to the French grid. The project is located close to Le Croisic, Western coast of France. SEM-REV is one of the main test facilities operated by Ecole Centrale de Nantes to support MRE technologies development. After presenting the initial motivations of the SEM-REV development, the paper describes, in parts 1 and 2, the complete administrative and technical processes that were followed to reach SEM-REV commissioning in 2014. The third part is focused on the exploitation process, including technical and contractual specifications imposed to the MRE developers for installation, tests and decommissioning phases. Some words are given also on the R and D projects using the SEM-REV in-situ monitoring system: prediction of environmental conditions, bio-fooling, acoustic impact. Even if operational phase is not started, expected extensions of the tests site are listed. (authors)

  16. Comparison of Wechsler Memory Scale-Fourth Edition (WMS-IV) and Third Edition (WMS-III) dimensional structures: improved ability to evaluate auditory and visual constructs.

    Science.gov (United States)

    Hoelzle, James B; Nelson, Nathaniel W; Smith, Clifford A

    2011-03-01

    Dimensional structures underlying the Wechsler Memory Scale-Fourth Edition (WMS-IV) and Wechsler Memory Scale-Third Edition (WMS-III) were compared to determine whether the revised measure has a more coherent and clinically relevant factor structure. Principal component analyses were conducted in normative samples reported in the respective technical manuals. Empirically supported procedures guided retention of dimensions. An invariant two-dimensional WMS-IV structure reflecting constructs of auditory learning/memory and visual attention/memory (C1 = .97; C2 = .96) is more theoretically coherent than the replicable, heterogeneous WMS-III dimension (C1 = .97). This research suggests that the WMS-IV may have greater utility in identifying lateralized memory dysfunction.

  17. GPU Computing Gems Emerald Edition

    CERN Document Server

    Hwu, Wen-mei W

    2011-01-01

    ".the perfect companion to Programming Massively Parallel Processors by Hwu & Kirk." -Nicolas Pinto, Research Scientist at Harvard & MIT, NVIDIA Fellow 2009-2010 Graphics processing units (GPUs) can do much more than render graphics. Scientists and researchers increasingly look to GPUs to improve the efficiency and performance of computationally-intensive experiments across a range of disciplines. GPU Computing Gems: Emerald Edition brings their techniques to you, showcasing GPU-based solutions including: Black hole simulations with CUDA GPU-accelerated computation and interactive display of

  18. Revised PROPELLER for T2-weighted imaging of the prostate at 3 Tesla: impact on lesion detection and PI-RADS classification

    Energy Technology Data Exchange (ETDEWEB)

    Meier-Schroers, Michael; Marx, Christian; Schmeel, Frederic Carsten; Wolter, Karsten; Block, Wolfgang; Sprinkart, Alois Martin; Traeber, Frank; Schild, Hans Heinz; Kukuk, Guido Matthias [University Hospital Bonn, Department of Radiology, Bonn (Germany); Gieseke, Juergen [Philips Healthcare Germany, Hamburg (Germany); Willinek, Winfried [Hospital of Barmherzige Brueder, Department of Radiology, Neuroradiology, Sonography and Nuclear Medicine, Trier (Germany)

    2018-01-15

    To evaluate revised PROPELLER (RevPROP) for T2-weighted imaging (T2WI) of the prostate as a substitute for turbo spin echo (TSE). Three-Tesla MR images of 50 patients with 55 cancer-suspicious lesions were prospectively evaluated. Findings were correlated with histopathology after MRI-guided biopsy. T2 RevPROP, T2 TSE, diffusion-weighted imaging, dynamic contrast enhancement, and MR-spectroscopy were acquired. RevPROP was compared to TSE concerning PI-RADS scores, lesion size, lesion signal-intensity, lesion contrast, artefacts, and image quality. There were 41 carcinomas in 55 cancer-suspicious lesions. RevPROP detected 41 of 41 carcinomas (100%) and 54 of 55 lesions (98.2%). TSE detected 39 of 41 carcinomas (95.1%) and 51 of 55 lesions (92.7%). RevPROP showed fewer artefacts and higher image quality (each p < 0.001). No differences were observed between single and overall PI-RADS scores based on RevPROP or TSE (p = 0.106 and p = 0.107). Lesion size was not different (p = 0.105). T2-signal intensity of lesions was higher and T2-contrast of lesions was lower on RevPROP (each p < 0.001). For prostate cancer detection RevPROP is superior to TSE with respect to motion robustness, image quality and detection rates of lesions. Therefore, RevPROP might be used as a substitute for T2WI. (orig.)

  19. Revised PROPELLER for T2-weighted imaging of the prostate at 3 Tesla: impact on lesion detection and PI-RADS classification

    International Nuclear Information System (INIS)

    Meier-Schroers, Michael; Marx, Christian; Schmeel, Frederic Carsten; Wolter, Karsten; Block, Wolfgang; Sprinkart, Alois Martin; Traeber, Frank; Schild, Hans Heinz; Kukuk, Guido Matthias; Gieseke, Juergen; Willinek, Winfried

    2018-01-01

    To evaluate revised PROPELLER (RevPROP) for T2-weighted imaging (T2WI) of the prostate as a substitute for turbo spin echo (TSE). Three-Tesla MR images of 50 patients with 55 cancer-suspicious lesions were prospectively evaluated. Findings were correlated with histopathology after MRI-guided biopsy. T2 RevPROP, T2 TSE, diffusion-weighted imaging, dynamic contrast enhancement, and MR-spectroscopy were acquired. RevPROP was compared to TSE concerning PI-RADS scores, lesion size, lesion signal-intensity, lesion contrast, artefacts, and image quality. There were 41 carcinomas in 55 cancer-suspicious lesions. RevPROP detected 41 of 41 carcinomas (100%) and 54 of 55 lesions (98.2%). TSE detected 39 of 41 carcinomas (95.1%) and 51 of 55 lesions (92.7%). RevPROP showed fewer artefacts and higher image quality (each p < 0.001). No differences were observed between single and overall PI-RADS scores based on RevPROP or TSE (p = 0.106 and p = 0.107). Lesion size was not different (p = 0.105). T2-signal intensity of lesions was higher and T2-contrast of lesions was lower on RevPROP (each p < 0.001). For prostate cancer detection RevPROP is superior to TSE with respect to motion robustness, image quality and detection rates of lesions. Therefore, RevPROP might be used as a substitute for T2WI. (orig.)

  20. Revision of Pachycentria (Melastomataceae)

    NARCIS (Netherlands)

    Clausing, Gudrun

    2000-01-01

    A revision of Pachycentria Blume, which includes the monotypic Pogonanthera Blume, is presented. Pachycentria comprises eight species and one subspecies. Two species, P. vogelkopensis and P. hanseniana, are newly described. The genus is distinguished from other genera in the Medinillinae by a small

  1. Revision of Oxandra (Annonaceae)

    NARCIS (Netherlands)

    Junikka, L.; Maas, P.J.M.; Maas-van de Kamer, H.; Westra, L.Y.Th.

    2016-01-01

    A taxonomic revision is given of the Neotropical genus Oxandra (Annonaceae). Within the genus 27 species are recognized, 4 of which are new to science. Most of the species are occurring in tropical South America, whereas a few (6) are found in Mexico and Central America and two in the West Indies

  2. Revision without ordinals

    NARCIS (Netherlands)

    Rivello, Edoardo

    2013-01-01

    We show that Herzberger’s and Gupta’s revision theories of truth can be recast in purely inductive terms, without any appeal neither to the transfinite ordinal numbers nor to the axiom of Choice. The result is presented in an abstract and general setting, emphasising both its validity for a wide

  3. Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. III. rev 3 mutant strains

    International Nuclear Information System (INIS)

    Lawrence, C.W.; Crhistensen, R.B.

    1979-01-01

    The role of rev3 gene function in uv-induced mutagenesis in the yeast Saccharomyces cerevisiae has been examined by determining the reversion of 12 well-defined cyc1 mutations in diploid strains homozygous for the rev3-1 or rev3-3 allale. The 12 cyc1 alleles include one ochre, one amber, four initiation, two proline missense, and four frameshift mutations. We find that the rev3 mutations reduce the frequency of UV-induced reversion of all of the cyc1 alleles, though different classes of alleles respond to a different extent. These results imply that the rev3 gene function is required for the production of a wide variety of mutational events, though probably not all, and show that each of the three rev loci have different mutational phenotypes. Such diverse phenotypes are not predicted by the unitary model for bacterial mutagenes, suggesting that this is at best an incomplete description of eukaryotic mutagenesis

  4. Innocuity and immune response to Brucella melitensis Rev.1 vaccine in camels (Camelus dromedarius

    Directory of Open Access Journals (Sweden)

    A. Benkirane

    2014-10-01

    Full Text Available A field trial was conducted in a camel brucellosis-free herd to evaluate antibody response to the Brucella melitensis Rev.1 vaccine in camels and assess shedding of the vaccine strain in milk. Twenty eight camels were divided into four groups according to their age and vaccination route. Groups A (n=3 and B (n=3 consisted of non-pregnant lactating female camels, vaccinated through subcutaneous and conjunctival routes, respectively. Groups C (n=10 consisted of 8-11 months old calves vaccinated through conjunctival route. The rest of the herd (n=12 composed of female and young camels were not vaccinated and were considered as the control group. Each animal from groups A, B and C was given the recommended dose of 2 x 109 colony forming units of Rev.1 vaccine irrespective of age or route of vaccination. Blood samples were collected from all the animals at the time of vaccination and at weekly, bi-weekly and monthly interval until 32 weeks post vaccination and from controls at weeks 8 and 24. The serological tests used were modified Rose Bengal Test, sero-agglutination test, and an indirect Enzyme Linked Immunosorbent Assay. Milk samples were collected from all vaccinated female camels and tested for the presence of Rev.1 vaccine strain. Most vaccinated animals started to show an antibody response at week 2 and remained positive until week 16. By week 20 post-vaccination all animals in the three groups were tested negative for Brucella antibodies. Bacteriological analysis of milk samples did not allow any isolation of Brucella melitensis. All samples were found Brucella negative in PCR analysis. The results of this study indicate that the Rev.1 vaccine induces seroconversion in camels. Rev.1 vaccine strain is not excreted in the milk of camels. These findings are promising as to the safe use of the Rev.1 vaccine in camels.

  5. Independent Examination of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): What Does the WAIS-IV Measure?

    Science.gov (United States)

    Benson, Nicholas; Hulac, David M.; Kranzler, John H.

    2010-01-01

    Published empirical evidence for the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV) does not address some essential questions pertaining to the applied practice of intellectual assessment. In this study, the structure and cross-age invariance of the latest WAIS-IV revision were examined to (a) elucidate the nature of the constructs…

  6. How to Get the Teaching Job You Want: The Complete Guide for College Graduates, Teachers Changing Schools, Returning Teachers and Career Changers. Second Edition

    Science.gov (United States)

    Feirsen, Robert; Weitzman, Seth

    2004-01-01

    Competition for the best teaching jobs is becoming more intense. Since publication of the first edition, when it was mainly the most desirable schools that were deluged by applications, the economic climate has made the teacher market more competitive across the board, and is changing hiring practices. Now extensively revised, this book maintains…

  7. Coefficients of Correlation of IQ's on the WAIS-R with Standard Age Scores on the Stanford-Binet, 4th Edition for Previously Identified Mentally Handicapped Adolescents.

    Science.gov (United States)

    Richardson, John C.

    This paper presents a study regarding the correlation of the Stanford-Binet: 4th Edition Intelligence Quotient (IQ) scores with the Wechsler Adult Intelligence Scale-Revised (WAIS-R) IQ scores for the purpose of improving the identification process for educable mentally handicapped (EMH) school age adolescents and young adults. The sample included…

  8. Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia.

    Science.gov (United States)

    Tamura, Satoru; Kaneko, Masafumi; Shiomi, Atsushi; Yang, Guang-Ming; Yamaura, Toshiaki; Murakami, Nobutoshi

    2010-03-15

    Bioassay-guided separation from the MeOH extract of the South American medicinal plant Sida cordifolia resulted in isolation of (10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (1) as an unprecedented NES non-antagonistic inhibitor for nuclear export of Rev. This mechanism of action was established by competitive experiment by the biotinylated probe derived from leptomycin B, the known NES antagonistic inhibitor. Additionally, structure-activity relationship analysis by use of the synthesized analogs clarified cooperation of several functionalities in the Rev-export inhibitory activity of 1. Copyright 2010 Elsevier Ltd. All rights reserved.

  9. Empirical investigation of wind farm blockage effects in Horn Rev 1 offshore wind farm

    DEFF Research Database (Denmark)

    Mitraszewski, Karol; Hansen, Kurt Schaldemose; Nygaard, Nicolai

    We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds and stabi......We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds...

  10. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P. [NERI, Dept. of Wildlife Ecology and Biodiversity, Roskilde (Denmark)

    2005-07-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  11. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Hounisen, J.P.

    2005-01-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  12. RevTrans: multiple alignment of coding DNA from aligned amino acid sequences

    DEFF Research Database (Denmark)

    Wernersson, Rasmus; Pedersen, Anders Gorm

    2003-01-01

    The simple fact that proteins are built from 20 amino acids while DNA only contains four different bases, means that the 'signal-to-noise ratio' in protein sequence alignments is much better than in alignments of DNA. Besides this information-theoretical advantage, protein alignments also benefit...... proteins. It is therefore preferable to align coding DNA at the amino acid level and it is for this purpose we have constructed the program RevTrans. RevTrans constructs a multiple DNA alignment by: (i) translating the DNA; (ii) aligning the resulting peptide sequences; and (iii) building a multiple DNA...

  13. RCC-MX (2008 edition)

    International Nuclear Information System (INIS)

    Bravo, X.; Drubay, B.

    2008-10-01

    The RCC-MX books is a compilation of design and construction rules for the mechanical materials of experimental reactors, for their auxiliaries and irradiation devices. This second edition includes the updates of references to NF, EN and ISO standards, the compliance with the regulations for nuclear pressure equipments, and the feedback since the 2005 edition. It comprises 9 books and a CD-Rom and includes a presentation document. The RCC-MX has been developed for the Jules Horowitz reactor but can be used for the design and construction of new projects of new experimental reactors or new equipments and devices for existing facilities. Content: - Book 1: general dispositions, materials for experimental reactors and their auxiliaries, for irradiation devices and for control or handling mechanisms, complementary requirements and particular dispositions; - Book 2: materials for the reactor and for its level 1 auxiliaries; - Book 3: materials for the reactor and for its level 2 and level 3 auxiliaries, control and handling mechanisms, materials for irradiation devices; - Book 4: technical appendixes - materials characteristics (steels and alloys); - Book 5: technical appendixes (design rules); - Book 6: technical specifications of materials; - Book 7: tests and control methods; - Book 8: welding; - Book 9: fabrication. (J.S.)

  14. Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

    Directory of Open Access Journals (Sweden)

    Hong Zan

    2012-11-01

    Full Text Available By diversifying the biological effector functions of antibodies, class switch DNA recombination (CSR plays a critical role in the maturation of the immune response. It is initiated by activation-induced cytidine deaminase (AID-mediated deoxycytosine deamination, yielding deoxyuridine (dU, and dU glycosylation by uracil DNA glycosylase (Ung in antibody switch (S region DNA. Here we showed that the translesion DNA synthesis polymerase Rev1 directly interacted with Ung and targeted in an AID-dependent and Ung-independent fashion the S regions undergoing CSR. Rev1−/− Ung+/+ B cells reduced Ung recruitment to S regions, DNA-dU glycosylation, and CSR. Together with an S region spectrum of mutations similar to that of Rev1+/+ Ung−/− B cells, this suggests that Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1−/− Msh2−/− B cells. Rescue of CSR in Rev1−/− B cells by a catalytically inactive Rev1 mutant shows that the important role of Rev1 in CSR is mediated by Rev1’s scaffolding function, not its enzymatic function.

  15. Fusion Canada issue 32. Final edition

    International Nuclear Information System (INIS)

    1997-07-01

    Fusion Canada is a bulletin of the National Fusion Program, this is the last edition. Included in this July edition are articles on Funding for Canada's fusion program, Research and Development on TdeV-96 , Divertor Maintenance Robotics and reference listing for Canada's Fusion research and development sites

  16. Bibliography of Fynbos ecology: 2nd edition

    CSIR Research Space (South Africa)

    Manders, PT

    1989-12-01

    Full Text Available The first edition of a bibliography of fynbos ecology was produced in 1981 and comprised 814 references to work completed or commenced prior to the initiation of the Fynbos Biome Project. It is appropriate that this second edition...

  17. The Aldine Edition of Aristotle's De Sensu

    DEFF Research Database (Denmark)

    Bloch, David Kristian

    2006-01-01

    This small article examines the quality of and the textual foundation for the først printed edition ever of Aristotle's De Sensu et Sensibilibus, that is, Aldus Manutius' (1497).......This small article examines the quality of and the textual foundation for the først printed edition ever of Aristotle's De Sensu et Sensibilibus, that is, Aldus Manutius' (1497)....

  18. Edit Distance to Monotonicity in Sliding Windows

    DEFF Research Database (Denmark)

    Chan, Ho-Leung; Lam, Tak-Wah; Lee, Lap Kei

    2011-01-01

    Given a stream of items each associated with a numerical value, its edit distance to monotonicity is the minimum number of items to remove so that the remaining items are non-decreasing with respect to the numerical value. The space complexity of estimating the edit distance to monotonicity of a ...

  19. Power energy. Systems for energy conversion. Compact knowledge for study and profession. 5. rev. and enl. ed.; Energietechnik. Systeme zur Energieumwandlung. Kompaktwissen fuer Studium und Beruf

    Energy Technology Data Exchange (ETDEWEB)

    Zahoransky, Richard A. (ed.); Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

    2010-07-01

    This textbook imparts to the reader a fundamental understanding for relations of energy conversion processes. It comprises the total spectra of energy engineering, starting with fundamentals of energy process engineering via description of operating power plants (all types) to energy distribution and - storage. Main topics are sustainable energy systems from renewable energy sources. combined systems (e.g. Gas/steam turbine power plants) and plants with cogeneration (e.g. modular cogeneration plants). A new chapter Kyoto-Protocol was created as a concept of emissions-free coal-fired power plants. A new wording for deregulation of energy markets was received. Numerous texts and graphs were been revised. Chapter 18 ''Deregulation of Energy Markets'' is newly revised. The 5th edition was actualized by new trends in energy engineering, chapter wind energy revised, and deregulation topics in the energy market extended. Due to its didactic concepts the book directs not only to students but also everybody, who is inerested into actual questions of energy engineering. (orig./GL)

  20. A Study on Improvement of Test Method of Nuclear Power Plant ESF ACS by applying Regulatory Guide 1.52 (Rev.3)

    International Nuclear Information System (INIS)

    Lee, Sook Kyung; Kim, Kwang Sin; Sohn, Soon Hwan; Song, Kyu Min; Lee, Kae Woo; Cho, Byoung Ho; Park, Jeong Seo; Yoo, Byeang Jea; Hong, Soon Joon; Kang, Sun Haeng

    2010-01-01

    U. S. NRC Regulation Guide 1.52 regulating ESF ACS in nuclear power plants has been revised to revision 3. To apply reduction of operability test time, allowance of alternative challenge agents for in-place leak test of HEPA filters, and upgrade of Methyl Iodide penetration acceptance criterion in activated carbon performance test suggested in Reg. Guide 1.52(Rev.3) on Yonggwang units 5 and 6 ESF ACSes, technical feasibility study was carried out with on-site experiments as well as experiments with a lab-scale model. It was confirmed that the moisture in the system returned to the level before the test in 1 or 4 days even though the moisture was removed during the operability test lasting more than 10 hours. Therefore, it is appropriate to perform monthly operability test in 15 minutes just long enough to check the operability of equipment. To change challenge material for in-place HEPA filter leak test, size of aerosol, production rate, and leak detection capability were compared for DOP and PAO. It was concluded that PAO can be substituted for DOP in nuclear power plants. The upgrade of Methyl Iodide penetration acceptance criterion from 0.175 % to 0.5 % in active carbon filter bed deeper than 4 inches was to conform to the change of activated carbon performance test method to ASTM D3803(1989). It was confirmed that Methyl Iodide penetration acceptance criterion of 0.5 % under 30 .deg. C