WorldWideScience

Sample records for rev ed voelkerrechtliche

  1. Radiotherapy. 2. rev. ed.; Strahlentherapie

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    Wannenmacher, Michael; Debus, Juergen [Radiologische Klinik, Heidelberg (Germany). Abteilung fuer Radioonkologie und Strahlentherapie; Wenz, Frederik (ed.) [Universitaetsmedizin Mannheim (Germany). Klinik fuer Strahlentherapie und Radioonkologie

    2013-07-01

    The purpose of this medical specialty book, besides presenting the state of the art in clinical radiotherapy and radiooncology, is to explain the basic principles of medical physics and radiobiology. Following a number of chapters on general topics and theory it provides detailed coverage of the individual organ systems, briefly addressing future aspects in the process. The authors relate their view that radiooncology as a medical specialty will continue to be under pressure to change and that it will take continuous innovation to secure its status within the interdisciplinary context around the treatment of cancer patients. The authors of this, the textbook's second edition, have dedicated much space to modern methods and techniques in order to do justice to these developments.

  2. Solar astrophysics. 3. rev. ed.

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    Foukal, Peter V. [CRI, Nahant, MA (United States)

    2013-06-01

    This third, revised edition describes our current understanding of the sun - from its deepest interior, via the layers of the directly observable atmosphere to the solar wind, right up to its farthest extension into interstellar space. It includes a comprehensive account of the history of solar astrophysics, and the evolution of solar instruments. This account now includes the most up- to-date implementation of modern solar instruments in facilities on the ground and in space. The revised book now also provides an overview of recent results on ''space weather'' and on sun-climate relations, both of which are fields of increasing societal importance.

  3. International treaties. United Nations, mutual assistance pacts, human rights, sea-, air- and space law, environmental law, peace law, German reunification, conventions of war. As of March 1, 1991. 5. rev. ed. Voelkerrechtliche Vertraege. Vereinte Nationen, Beistandspakte, Menschenrechte, See-, Luft- und Weltraumrecht, Umweltrecht, Kriegsverhuetungsrecht, Deutsche Einheit, Kriegsrecht. Stand 1. Maerz 1991

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    Randelzhofer, A. (ed.)

    1991-01-01

    The 5th edition of this book dating from 1 March 1991 takes into account German unification; the previous treaties and legal documents are out of date in this regard. The book is divided into: international organizations; mutual assistance, friendship and partnership treaties; diplomacy, international treaties; human rights; international sea, air and space law; environmental law; settlement of disputes, measures for peace, disarmament; German unification; conventions of war. (HSCH).

  4. International treaties: United Nations; mutual assistance pacts; human rights; maritime law, air law, space law; environmental law; law for the prevention of war; German unification. Full-text edition. As of January 1994. 6. new rev. ed. Voelkerrechtliche Vertraege: Vereinte Nationen, Beistandspakte, Menschenrechte, See-, Luft- und Weltraumrecht, Umweltrecht, Kriegsverhuetungsrecht, deutsche Einheit. Textausgabe. Stand Januar 1994

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    Randelzhofer, A. (ed.)

    1994-01-01

    The book contains amongst others the following texts: Convention on Long-Range Transboundary Air Pollution (of 13.11.1979); Protocol to the 1979 Convention on Long-Range Transboundary Air Pollution on the Reduction of Sulphur Emissions or their Transboundary Fluxes by at least 30 per cent (of 8.7.1985); Protocol to the 1979 Convention on Long-Range Transboundary Air Pollution Concerning the Control of Emissions of Nitrogen Oxides or their Transboundary Fluxes (of 31.10.1988); Vienna Convention for the Protection of the Ozone Layer (of 22.3.1985); Montreal Protocol on Substances that Deplete the Ozone Layer (of 16.9.1987); Agreement on Early Notification in the Event of Nuclear Accidents (of 26.9.1986); Agreement on Mutual Assistance in the Event of Nuclear Accidents or Radiological Emergencies (of 26.9.1986). (HW)

  5. Radiology of osteoporosis. 2. rev. ed

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    Grampp, S. (ed.) [Dr. Grampp und Dr. Henk OEG Roentgenordination, Stockerau (Austria)

    2008-07-01

    This second edition of Radiology of Osteoporosis has been fully updated so as to represent the current state of the art. It provides a comprehensive overview of osteoporosis, the pathologic conditions that give rise to osteoporosis, and the complications that are frequently encountered. After initial chapters devoted to pathophysiology, the presentation of osteoporosis on conventional radiographs is illustrated and discussed. Thereafter, detailed consideration is given to each of the measurement methods employed to evaluate osteoporosis, including dual x-ray absorptiometry, vertebral morphometry, spinal and peripheral quantitative computed tomography, quantitative ultrasound, and magnetic resonance imaging. The role of densitometry in daily clinical practice is appraised. Finally, a collection of difficult cases involving pitfalls is presented, with guidance to their solution. The information contained in this volume will be invaluable to all with an interest in osteoporosis. (orig.)

  6. Agricultural crops. 8. rev. ed.; Nutzpflanzen

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    Lieberei, Reinhard; Reisdorff, Christoph [Univ. Hamburg (Germany). Abt. Nutzpflanzenbiologie/Angewandte Oekologie

    2012-07-01

    More than 75,000 plants are edible for human beings. Nearly 5,000 plants or utilized agriculturally or industrially. The authors of the book under consideration report on the most important agricultural crops and their application. The book is suitable for the beginner as well as for the advanced student. The book consists of three sections: The general section describes the morphology, anatomy and ingredients of the plants. The special section presents the individual agricultural crops. The appendix summarizes the actual data of production.

  7. Imaging pelvic floor disorders. 2. rev. ed.

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    Stoker, Jaap [Amsterdam Univ. (Netherlands). Dept. of Radiology; Taylor, Stuart A. [University College Hospital, London (United Kingdom). Dept. of Specialist X-Ray; DeLancey, John O.L. (eds.) [Michigan Univ., Ann Arbor, MI (United States). L4000 Women' s Hospital

    2008-07-01

    This volume builds on the success of the first edition of imaging pelvic floor disorders and is aimed at those practitioners with an interest in the imaging, diagnosis and treatment of pelvic floor dysfunction. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving field. Introductory chapters fully elucidate the anatomical basis underlying disorders of the pelvic floor. State of the art imaging techniques and their application in pelvic floor dysfunction are then discussed in detail. Additions since the first edition include consideration of the effect of aging and new chapters on perineal ultrasound, functional MRI and MRI of the levator muscles. The closing sections of the book describe the modern clinical management of pelvic floor dysfunction, including prolapse, urinary and faecal incontinence and constipation, with specific emphasis on the integration of diagnostic and treatment algorithms. (orig.)

  8. Boundless energy. 2. rev. ed.; Grenzenlose Energie

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    Haege, Walter

    2007-07-01

    For thousands of years, all cultures of man have described and researched life energy, whether they called it Qi, Chi, Prana, Od or Orgon. Since Rupert Sheldrake published his theory of morphogenetic fields, the subject has been accessible to the population in general and is contributing to the decline of the current paradigm of science. Knowledge that seamed indisputable since the time of Newton and Descartes is waning, and science must restructure itself on quite a different basis. Einstein, too, is becoming history. The book spans the discoveries of Lord Kelvin to Nikola Tesla to Prof. Dr.-Ing. K. Meyl whose potential eddy theory leads to a new understanding of the world. The key to this is the neutrino, and the fundamentals of neutrino physics are quite simple: At every moment, more than 60 thousand millions of neutrinos flow through us, controlling everything that exists. In his book, author Walter Haege shows how we can all utilise this indispensable neutrino power. It is a book for everyday practice, an indispensable reference manual for all those who intend a radical change in their view of the world and their way of living. (orig.) [German] Seit Jahrtausenden wird in allen Kulturen jene Energie beschrieben und erforscht, die uns steuert und unsere Zeit am Leben erhaelt, jene Energie mit den vielen Namen, von denen uns die bekanntesten, Qi, Chi, Prana, Od oder Orgon vielleicht gelaeufig sind. Seit Rupert Sheldrake und seiner wieder aufgegriffenen Theorie vom morphogenetischen Feld ist dieses Thema grossen Bevoelkerungskreisen neu zugaenglich geworden und traegt dazu bei, dass das jetzige Paradigma der Wissenschaften seinem Ende zugeht. Unser gesichertes Wissen, seit Newton und Descartes scheinbar unumstoesslich, geht dahin und die Wissenschaft muss sich auf gaenzlich anderer Grundlage neu formieren. Auch Einstein wird Geschichte. Die Wirbelphysik Lord Kelvins fuehrt uns ueber die sensationellen Entdeckungen Nikola Teslas zu dem Physiker Prof. Dr.-Ing. K. Meyl, der uns mit seiner Theorie der Potenzialwirbel zu einem neuen Weltverstaendnis fuehrt. Der Schluessel dazu heisst Neutrinos, wobei die Grundlage der Neutrinophysik gaenzlich einfach zu verstehen ist: Mehr als 60 Milliarden Neutrinos pro Sekunde und Quadratzentimeter - aus dem Weltraum kommend - durchfliessen uns und steuern alles was ist. Walter Haege zeigt in diesem Buch praktisch auf, wie jeder von uns diese so notwendige Neutrino-Energie selbst nutzen kann. Es Ist deshalb ein Praxisbuch, dessen Inhalt unverzichtbar fuer jenen Menschen ist, der seine Sicht der Welt und damit sein gesamtes Leben radikal auf neue Fuesse stellen will. (orig.)

  9. Neuroradiology. 4. rev. and enl. ed.; Neuroradiologie

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    Jansen, Olav; Forsting, Michael; Sartor, Klaus

    2008-07-01

    The book on neuroradiology covers the following topics: methods and normal diagnostic findings, brain malformations and development disorders, epilepsy diagnostics, traumatic consequences, carcinomas and tumor-like diseases, vascular diseases, infections and inflammations, demyelinising and degenerative diseases, spinal carcinomas and tumor-like diseases, spinal blood vessel diseases, demyelinising and degenerative diseases of the spinal cord, degenerative diseases of the vertebral column, other diseases of vertebral column and spinal cord, interventions in the head (therapy), spinal interventions (therapy), radiation protection, neuroradiological expertises.

  10. Pediatric uroradiology. 2nd rev. ed.

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    Fotter, Richard (ed.) [Univ. Hospital Medical Univ. Graz (Austria). Div. of Pediatric Radiology

    2008-07-01

    Since the first edition of Pediatric Uroradiology, very significant advances have been made in the imaging and treatment of common and important pediatric urologic disorders such as vesicoureteric reflux, urinary tract infection, and upper urinary tract dilatation. This revised and extended version takes full account of the sometimes dramatic changes. Where appropriate, new contents have been included, e.g., on genetics, while other information that continues to be pertinent has been retained. This book describes in detail all aspects of pediatric uroradiology. While it is written primarily from the point of view of the radiologist, it includes essential information for the pediatrician, pediatric surgeon, and urologist. It is specifically designed to aid the clinician in decisions on imaging management. The newest techniques and the changing relevance of imaging and interventional procedures are presented, and the diverse problems associated with the changing anatomy, physiology, and pathophysiology from the newborn period to adulthood are explained. The whole spectrum of imaging features of agenesis, anomalies, dysplasia, parenchymal diseases, neoplastic diseases, stone disease, renal vascular hypertension, renal failure, renal transplantation, and genitourinary trauma is covered. Individual chapters are devoted to vesicoureteric reflux, urinary tract infection, upper urinary tract dilatation, voiding dysfunction, and neurogenic bladder. A new chapter on the clinical management of common nephrourologic disorders, with the subtitle 'guidelines and beyond,' explains how imaging is embedded in the whole process of clinical management today. Short conclusions are included at the end of chapters and sections to provide the reader with the key information on the specific topic under consideration. (orig.)

  11. Ion Beam Synthesis of Ge Nanowires. rev. ed.

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    Mueller, T.

    2001-01-01

    The formation of Ge nanowires in V-grooves has been studied experimentally as well as theoretically. As substrate oxide covered Si V-grooves were used formed by anisotropic etching of (001)Si wafers and subsequent oxidation of their surface. Implantation of 1 x 10{sup 17} Ge{sup +}cm{sup -2} at 70 keV was carried out into the oxide layer covering the V-grooves. Ion irradiation induces shape changes of the V-grooves, which are captured in a novel continuum model of surface evolution. It describes theoretically the effects of sputtering, redeposition of sputtered atoms, and swelling. Thereby, the time evolution of the target surface is determined by a nonlinear integro-differential equation, which was solved numerically for the V-groove geometry. A very good agreement is achieved for the predicted surface shape and the shape observed in XTEM images. Surprisingly, the model predicts material (Si, O, Ge) transport into the V-groove bottom which also suggests an Ge accumulation there proven by STEM-EDX investigations. In this Ge rich bottom region, subsequent annealing in N{sub 2} atmosphere results in the formation of a nanowire by coalescence of Ge precipitates shown by XTEM images. The process of phase separation during the nanowire growth was studied by means of kinetic 3D lattice Monte-Carlo simulations. These simulations also indicate the disintegration of continuous wires into droplets mediated by thermal fluctuations. Energy considerations have identified a fragmentation threshold and a lower boundary for the droplet radii which were confirmed by the Monte Carlo simulation. The here given results indicate the possibility of achieving nanowires being several nanometers wide by further growth optimizations as well as chains of equally spaced clusters with nearly uniform diameter. (orig.)

  12. Advanced wood burning furnaces. 2. rev. ed.; Moderne Holzfeuerungsanlagen

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    Schneider, W. (comp.)

    2001-07-01

    New and environment-friendly technologies meet high requirements in terms of emission reduction and comfort of operation. In the field of wood burning furnaces, there is still a lack of knowledge which results in excessive cost, environmental pollution and loss of image. This brochure shows how wood furnaces should be operated correctly and also reviews the state of the art. [German] Durch die technische Entwicklung neuer, wirkungsvoller und vor allem umweltfreundlicher Heiztechniken wird zudem den in den letzten Jahren gestiegenen Anforderungen an den Emissionsschutz und den Bedienungskomfort Rechnung getragen. Mit Holz wird jedoch z. T. nicht immer richtig geheizt. Das kostet Geld und fuehrt zu vermeidbaren Umweltbelastungen und Imageschaeden. Ziel dieser Broschuere ist es daher, mit den Techniken des Heizens mit Holz vertraut zu machen und einen Ueberblick ueber den heutigen Stand zu geben. (orig.)

  13. Physics for engineers. 15. rev. ed.; Physik fuer Ingenieure

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    Siebke, W. [Fachhochschule Koblenz (Germany); Simon, G.; Wuttke, W. [comps.] [Westsaechsische Hochschule Zwickau (FH) (Germany); Lindner, H.

    1999-07-01

    This is the 15th, completely revised edition of this standard textbook. Rather than presenting the current state of knowledge in physics, the book aims at presenting the fundamentals of physics in a more up-to-date manner. This applies especially to the pictures and graphical illustrations, which have been replaced or modified so as to meet modern standards. [German] Der LINDNER, Physik fuer Ingenieure, ist ein seit vielen Jahren eingefuehrtes Lehrbuch, das auf Grund seiner weiten Verbreitung bereits zu den Klassikern unter den einfuehrenden Lehrbuechern gezaehlt werden kann. Trotz zahlreicher Verbesserungen in den frueheren Auflagen schien aber nicht zuletzt auf Grund der gestiegenen Anforderungen in den Studiengaengen eine gruendliche Ueberarbeitung des Lehrbuches unumgaenglich: In der neubearbeiteten 15. Auflage wurde der gesamte Stoff einer kritischen Sichtung unterzogen. Viele Kapitel und Abschnitte wurden dabei neu verfasst und den aktuellen Anforderungen angepasst. Zielsetzung war dabei nicht so sehr, den aktuellen Stand der Technik in der Physik darzustellen, sondern die Grundlagen in eine zeitgemaesse Form zu bringen. Die Neubearbeitung betrifft auch das gesamte Bildmaterial. Entbehrliches wurde entfernt, Bewaehrtes beibehalten und viel Neues hinzugefuegt, so dass auch die grafische Gestaltung den veraenderten Anspruechen entspricht. (orig.)

  14. Contrast media. Safety issues and ESUR guidelines. 2. rev. ed.

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    Thomsen, Henrik S. [Copenhagen University Hospital, Herlev (Denmark). Dept. of Diagnostic Radiology; Copenhagen Univ., Herlev (Denmark). Dept. of Diagnostic Sciences; Webb, Judith A.W. (eds.) [St. Bartholomew' s Hospital London Univ. (United Kingdom). Dept. of Radiology

    2009-07-01

    In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned members, reviewed the literature, proposed guidelines and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006. This second edition not only updates the previous edition, but also contains some completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues. Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are addressed, and the well-known ESUR guidelines on contrast media are included. This book, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media. (orig.)

  15. Paediatric radiology. 2. enl. and tot. rev. ed.; Kinderradiologie

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    Benz-Bohm, G. (ed.)

    2005-07-01

    This book presents a current, comprehensive and clearly written introduction to the often-neglected field of paediatric radiology, from important aspects of radiation protection to the specific anatomic features of the growing skeleton and the special anatomy of the thorax and abdomen of newborns and infants. Special knowledge is imparted on the radiology of trauma effects in infant age and the 'battered child syndrome'. The diseases and findings are presented in an organ-specific and topographic manner. There are special chapters on sonography, CT and MRT in infants. The structure of the book serves two purposes. First, the reader can obtain information on specific diseases; secondly, the particular features of examination techniques and the specifics of paediatric radiology are presented. (orig.) [German] Der grosse Umfang des Faches Radiologie hat schon vor vielen Jahren dazu gefuehrt, dass die Kinderradiologie als eigener Schwerpunkt eingerichtet und weiter entwickelt wurde. Bedeutung und Besonderheiten der Kinderradiologie werden aber dennoch in der Weiterbildung des Allgemeinradiologen nicht genuegend beruecksichtigt und gewuerdigt. Intensives Training und ausreichende eigene Erfahrung bei kinderradiologischen Untersuchungen sind nur bedingt gegeben bzw. werden in der Weiterbildung vermittelt. Umso wichtiger ist eine aktuelle, gruendliche und gut nachvollziehbare Aufarbeitung aller kinderradiologischen Themen zum Nachlesen und Nachschlagen. Dazu gehoert die Darstellung wichtiger Aspekte des Strahlenschutzes, die Eroerterung spezieller anatomischer Gegebenheiten des wachsenden Skeletts sowie der besonderen Anatomie von Thorax und Abdomen beim Saeugling und Kleinkind. Auch die Radiologie der Traumafolgen im Kindesalter und das ''Battered child syndrome'' verlangen besondere Expertise und Kenntnisse. Die Autoren haben alle fuer die Radiologie wesentlichen Erkrankungen des Kindesalters organbezogen bzw. topographisch aufgearbeitet und systematisch dargestellt. Darueber hinaus sind in eigenen Kapiteln die untersuchungstechnischen Besonderheiten der Sonographie, Computertomographie und Magnetresonanztomographie im Kindesalter erlaeutert worden. Mit dieser Gliederung ist es moeglich, sich ueber spezielle Krankheitsbilder zu informieren, sie erlaubt aber auch, sich in ein Untersuchungsverfahren einzuarbeiten und die Besonderheiten der Kinderradiologie kennen zu lernen. (orig.)

  16. Industrial inorganic chemistry. 2. Rev. Ed. Industrielle anorganische Chemie

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    Buechner, W.; Schliebs, R.; Winter, G.; Buechel, K.H.

    1986-01-01

    Inorganic chemistry is a branch of considerable economic and technical importance. Apart from supplying the market with metals, fertilizers, building materials, pigments and glass it is one of the major suppliers of process materials to the organic chemical industry. Many modern products of other industrial sectors (video tapes, optical fibers or silicon chips) could not have been developed and manufactured without the achievements of industrial inorganic chemistry. The publication is the first of its kind to give a compact description of the inorganic chemistry sector. A clearly arranged survey facilitates access to production processes, economic aspects, ecological implications, energy consumption and raw material consumption as well as to many other data and facts. Due to its clear arrangement and the combination of technical and economic facts the book is a valuable source of information.

  17. Physics of organic semiconductors. 2. compl. new rev. ed.

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    Bruetting, Wolfgang [Augsburg Univ. (Germany). Inst. fuer Physik; Adachi, Chihaya (eds.) [Kyushu Univ., Fukuoka (Japan). Center for Future Chemistry

    2012-07-01

    The field of organic electronics has seen a steady growth over the last 15 years. At the same time, our scientific understanding of how to achieve optimum device performance has grown, and this book gives an overview of our present-day knowledge of the physics behind organic semiconductor devices. Based on the very successful first edition, the editors have invited top scientists from the US, Japan, and Europe to include the developments from recent years, covering such fundamental issues as: - growth and characterization of thin films of organic semiconductors, - charge transport and photophysical properties of the materials as well as their electronic structure at interfaces, and - analysis and modeling of devices like organic light-emitting diodes or organic lasers. The result is an overview of the field for both readers with basic knowledge and for an application-oriented audience. It thus bridges the gap between textbook knowledge largely based on crystalline molecular solids and those books focusing more on device applications.

  18. Air pollution prevention manual on emission monitoring. 2. rev. ed.

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    NONE

    2008-08-15

    The Manual on Emission Monitoring covers the need for information about the national practice in the field of emission control at plants, requiring official approval. The legal bases for discontinuous and continuous measurements for emission control at plants, requiring official approval, are treated. Thereby also the European environmental legislation is considered. The publication procedure for testing institutes, which execute such measurements, is described. The execution of discontinuous emission measurements (course of the measurement and measurement requests) and for continuous emission measurement (suitability test, installation, maintenance, functional test and calibration of the automated measuring system) including the evaluation and documentation of the measured values is described. The procedure of remote emission monitoring is explained. The most important measuring procedures (continuous and discontinuous) are reported. The guide also includes an up-to-date list of tested and appropriate measurement devices. Such tested measuring devices are described by their manufacturers. Indications are given as to how the devices function together with their technical data (e. g. parameters from the suitability test). (orig.)

  19. Key to steel. 16. rev. and enlarged ed. Stahlschluessel

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    Wegst, C.W.

    1992-01-01

    The DIN substance reference numbers and abbreviations have been related to the trademarks of the steelworks and steel supplies. DIN specifications are compared with foreign specifications for different types of steel (e.g. structural steel, tool steel, noble steel, high-temperature steel). (MM).

  20. British Columbia 1998 mineral exploration review; rev. ed.

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    Schroeter, T.G.

    1999-01-01

    The review discusses mining and exploration highlights, government initiatives, and outlook for 1999. Mining covers the locations of 14 metal, eight coal, ten industrial mineral mines, and one tailings project. Exploration highlights cover metals, massive sulphide deposits, porphyry and related deposits, precious metal bearing veins and bulk-mineable deposits, skarn/manto deposits, magmatic nickel, coal deposits, and industrial minerals. Information is tabulated on the 1998 forecast value of solid mineral production and on new mines, closures, development, advanced exploration projects, and exploration highlights. 9 figs., 3 tabs.

  1. Pellet fired appliances. Market survey. 7. rev. ed.; Pelletheizungen. Marktuebersicht

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    NONE

    2013-01-15

    The market survey under consideration reports on pellet central heating systems and pellet fired appliances. The main chapters of this market survey are concerned to: (1) Information on wood pellets and pellet fired appliances; (2) Information about the interpretation of the market survey; (3) Survey of all compared pellet fired appliances with respect to the nominal power; (4) Price lists of pellet fired appliances and pellet central heating systems; (5) Type sheets of the compared pellet fired appliances and pellet central heating systems. Finally, this brochure contains the addresses of the produces and distribution partners of pellet fired appliances and pellet central heating systems.

  2. Diesel engines in practice. 8. rev. ed. Dieselmotoren-Praxis

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    Baentsch, E.

    1987-01-01

    The well-known manual has been completely revised and re-edited. A brief historical and economic review is followed by a discussion of the following subjects: Torque and power; fuel consumption; lube oil and cooling water; mass balance in multicylinder engines; oversquare and undersquare engines; suction engines and supercharged engines; two-stroke and four-stroke engines; engine selection; combustion processes; exhaust emissions; diesel engines in operation; cooling; piping; lubrication; starting; practical tests; variable-fuel engines. (HWJ).

  3. Environmental law. 2. rev. and enl. ed.; Umweltrecht

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    Koch, H.J. (ed.) [Hamburg Univ. (Germany). Forschungsstelle Umweltrecht

    2007-07-01

    The text book under consideration already is addressed to lawyers and students of jurisprudence. It enables an introduction into the general environmental law and consists of sixteen autonomous chapters: (a) International law in the field of ecology (Matthias Buck, Roda Verheyen); (b) European and national environmental constitutional law (Johannes Caspar); (c) General environmental administrative law (Ulrich Ramsauer); (d) Pollution abatement law (Hans-Joachim Koch); (e) Water protection law (Silke Laskowski, Cornelia Ziehm); (f) Recycling economy law and waste management law (Martin Dieckmann, Moritz Reese); (g) Nature conservation law (Christian Maass, Peter Schuette); (h) Soil conservation law and contaminated sites law (Nikolaus Herrmann); (i) Energy legal regulations as an instrument of environmental protection (Wolfgang Ewer); (j) Atomic energy law (Klaus Jankowski); (k) Genetic engineering law (Ursula Prall); (l) Law of hazardous materials (Eckhard Pache); (m) Environmental law in planning law (Nikolaus Hermann); (n) Environment and traffic (Philipp Hermann, Ekkehard Hofmann); (o) Agriculture and ecology (Ulf-Henning Moeker); (p) Liberal trade and environmental protection (Matthias Buck).

  4. Environmental law. 2. rev. and enl. ed.; Umweltrecht

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    Erbguth, W. [Rostock Univ. (Germany); Schlacke, S. [Bremen Univ. (Germany)

    2008-07-01

    The text book under consideration is addressed to students of jurisprudence. It enables an entrance into the general environment law and into selected areas of the special environment law in a clear and systematic form. After an introduction of fundamental principles of the environment law, the book consists of the following topics: Basic principles of the environment law; environmental constitutional law; instruments of the environment law; legal protection in the environment law; environmental European right; environmental international law; pollution protection law; wilderness protection act and landscape conservation act, water protection right, act on recycling and waste management, soil conservation law and contaminated site law, genetic engineering law, sea environment law for the protection of the North Sea and Baltic Sea, energy right.

  5. Neurology check list. 5. rev. and enl. ed.; Checkliste Neurologie

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    Grehl, Holger [Evangelisches und Johanniter Klinikum, Duisburg (Germany). Neurologische Klinik; Reinhardt, Frank

    2013-02-01

    The neurology check list covers the following issues, organized in four parts: Grey part - diagnostic fundamentals, therapeutic principles: clinical neurological examination, liquor puncture, specific laboratory diagnostics, neurophysical diagnostics, imaging techniques, therapeutic principles, legal aspects, neurological assessment. Green Part - leading syndromes and leading symptoms. Blue part - neurological disease appearance: pains in head and face, pain syndrome, congenital and development disturbances, liquor circulation disturbances, ZNS hemorrhages, tumors and neoplasm, paraneoplastic syndromes, inflammatory diseases of the nervous system, dementia diseases, metabolic and other encephalopathy, cerebellum diseases and system surmounting processes, movement degeneration, basal ganglion diseases, epilepsy, non-epileptic attacks, medulla diseases, brain nerve diseases, plexus lesions, radicular lesions, peripheric neuropathy, neuromuscular transfer disturbances, muscular diseases. Red part: neurological intensive medicine.

  6. Residues from waste incineration. Final report. Rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Astrup, T.; Juul Pedersen, A.; Hyks, J.; Frandsen, F.J.

    2010-04-15

    The overall objective of the project was to improve the understanding of the formation and characteristics of residues from waste incineration. This was done focusing on the importance of the waste input and the operational conditions of the furnace. Data and results obtained from the project have been discussed in this report according to the following three overall parts: i) mass flows and element distribution, ii) flue gas/particle partitioning and corrosion/deposition aspects, and iii) residue leaching. This has been done with the intent of structuring the discussion while tacitly acknowledging that these aspects are interrelated and cannot be separated. Overall, it was found that the waste input composition had significant impact of the characteristics of the generated residues. A similar correlation between operational conditions and residue characteristics could not be observed. Consequently, the project recommend that optimization of residue quality should focus on controlling the waste input composition. The project results showed that including specific waste materials (and thereby also excluding the same materials) may have significant effects on the residue composition, residue leaching, aerosol and deposit formation.It is specifically recommended to minimize Cl in the input waste. Based on the project results, it was found that a significant potential for optimization of waste incineration exist. (Author)

  7. Inform@ed space

    DEFF Research Database (Denmark)

    Bjerrum, Peter; Olsen, Kasper Nefer

    2001-01-01

    Inform@ed space Sensorial Perception And Computer Enchancement - bidrag til Nordisk Arkitekturforskningsforenings IT-konference, AAA april 2001.......Inform@ed space Sensorial Perception And Computer Enchancement - bidrag til Nordisk Arkitekturforskningsforenings IT-konference, AAA april 2001....

  8. 12MW Horns Rev experiment

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Peña, A.; Mikkelsen, Torben

    The 12MW project with the full title ‘12 MW wind turbines: the scientific basis for their operation at 70 to 270 m height offshore’ has the goal to experimentally investigate the wind and turbulence characteristics between 70 and 270 m above sea level and thereby establish the scientific basis...... relevant for the next generation of huge 12 MW wind turbines operating offshore. The report describes the experimental campaign at the Horns Rev offshore wind farm at which observations from Doppler Laser LIDAR and SODAR were collected from 3 May to 24 October 2006. The challenges for mounting...... profile. Further studies on this part of the work are on-going. Technical detail on LIDAR and SODAR are provided as well as theoretical work on turbulence and atmospheric boundary layer flow. Selected results from the experimental campaign are reported....

  9. PREFACE: EDS2010 Preface

    Science.gov (United States)

    Heggie, Malcolm I.

    2011-03-01

    The biennial international conference on Extended Defects in Semiconductors started in 1978 with a meeting in Hünfeld, Germany. Subsequent meetings rotated between Poland, France, Great Britain, Germany, Russia and Italy, culminating in EDS2004 in Chernogolovka, EDS2006 in Halle and EDS2008 in Poitiers. EDS2010 was held at the University of Sussex at Brighton, UK from September 19th to 24th. An extension of the tabulation of this history, which first appeared on the EDS2006 website, is given in the attached PDF. It is with sadness that we note one of the founders of the series, Prof. Dr Helmut Alexander, passed away on 3 December 2009 and we were proud to dedicate EDS2010 to his memory. It has become a tradition to make an award in his name, and this year it was made to Ivan Isacov for his poster "Electrical levels of dislocation networks in p- and n-type silicon". A short and warm celebration of Prof. Dr Alexander's life by his friends and colleagues, Prof. Drs Helmut Gottschalk, Eicke Weber and Wolfgang Schröter, is included in this volume. The conference was a forum for the state-of-the-art of investigation and modelling of extended defects in semiconductors. Scientists from universities, research institutes and industry made contributions to a deeper understanding of extended defects, their interaction with point defects and their role in the development of semiconductor technology. The remit of the conference included extended defects, nanostructures, nanoparticles, quantum dots and interfaces within semiconducting materials ranging from narrow to wide band gaps, including graphene-derived materials and diamond. Scientific interests range from defect geometry, electronic structure, dynamics, spectroscopy, microscopy, reactions and chemistry to introduction mechanisms, such as implantation and strained layers and the operation of devices such as integrated circuits, heterostructures, and solar cells. The organisers were confronted with a long period between

  10. Ed Deutschman Interview [video

    OpenAIRE

    Deutschman, Ed

    2011-01-01

    Background: Ed Deutschman was a Navy cadet at the Del Monte Pre-Flight School, located at the now (2013) Naval Postgraduate School. Mr Deutschman visited the Dudley Knox Library on May 2, 2011, and spoke about his service in World War II as a Corsair fighter pilot in the Pacific.

  11. Radiation sources for engineering and medicine. 2. rev. and enl. ed.; Strahlungsquellen fuer Technik und Medizin

    Energy Technology Data Exchange (ETDEWEB)

    Krieger, Hanno

    2013-07-01

    The book on radiation sources for engineering and medicine includes the following issues: Part I: Particle accelerators: review on radiation sources; fundamentals on particle accelerators and radiation optics; electron an ion sources, the X-ray tube; DC accelerators; high-frequency generators; hollow wave guides and cavity resonators; linear accelerators; medical electron linear accelerators; ring accelerators; synchrotron radiation and storage rings. Part II: Nuclear reactors and neutron sources: nuclear reactors; neutron sources and their applications. Part III: Radionuclides and their application: radionuclide production; radionuclides in medicine; cobalt radiation facilities for medicine; afterloading facilities for medicine; technical applications for radionuclides. Part IV: Attachments: tables; literature.

  12. Pollution control in Eastern and Western Germany. 2. Rev. Ed. Umweltschutz in beiden Deutschen Staaten

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    The various sectors of environmental policy are considered. Reference is made to waters, air, waste processing, noise etc. The respective situations are described and taken a critical look at both in relation to the Federal Republic of Germany and the German Democratic Republic. Measures to be taken are scrutinized in the same way. In conclusion environmental experiences gained in the Eastern and Western part of Germany lead to theses such as the following: - The communist ideology, refering to the two parts of Germany, cannot prove that the communist system is bound to promote pollution control whereas the democratic system of the Federal Republic of Germany is bound to smother it. In recent years both the Eastern and Western population has increasingly grown conscious of the enivronment. Attitudes and opinions are increasingly influencing political decision making. On the whole this development is an ideal basis for further positive advancements. According to scientifically proven technological know-how and socio-economic efficiency, conventional environmental loads can be counteracted by measures which will presumably bring about a positive change and trends towards recovery - both parts of Germany are disposing of balances giving proof of the fact that, as a matter of fact, our essential conditions for life are not inevitably bound to be destroyed. Not at all are these balances inferior to international standards. What remains to be done now is to realize the alternatives developed and tested by scientific and technical research. Convenient reorganizations and rearrangements will contribute to prompt, financially and organizationally feasible solutions. (orig./HSCH).

  13. The MR trainer. Upper extremities. 2. rev. and enl. ed.; Der MR-Trainer. Obere Extremitaet

    Energy Technology Data Exchange (ETDEWEB)

    Breitenseher, Martin [Landesklinikum Waldviertel Horn (Austria). Inst. fuer Radiologie und Interventionelle Radiologie

    2016-05-01

    The MR (magnetic resonance) trainer covers the indications in NMR images of hands, elbows and shoulder, including fractures and instabilities at the wrist, tendon and ligament lesions, carpal tunnel syndrome, ulnar tunnel syndrome, scaphoid bone fracture, (posttraumatic) osteonecrosis, synovial lesions, luxations, osteocondrosis, soft tissue rumors and bone tumors. The book includes training tasks for each issue.

  14. Diagnostic radiography in orthopedics. Focusing techniques; 3. new rev. ed.; Orthopaedische Roentgendiagnostik. Einstelltechnik

    Energy Technology Data Exchange (ETDEWEB)

    Bernau, A.

    1995-12-31

    After the introductory chapters dealing inter alia with approaches to defining the imaging tasks in relation to the anatomical regions to be exposed, and the relevant positioning, or aspects of radiological protection, positioning aids, and image optimization, the textbook presents a comprehensive guide to good imaging based on the functional approach commonly used in orthopedics, showing and explaining standard radiographs of the skeleton. The main aspect in this richly illustrated key part of the book is the focusing techniques best suitable for imaging the skull, the spine, the thorax and shoulders, the upper limbs, the pelvic region, and the lower limbs. (MG). 577 figs. [Deutsch] Nach einleitenden Kapiteln, die sich u.a. mit der anatomischen Orientierung, Strahlenschutzaspekten, Lagerungshilfen und Bildoptimierung befassen, wird eine der funktionellen Betrachtungsweise in der Orthopaedie angepasste Normierung der Skelettaufnahmen versucht. Dieser sich mit der Einstelltechnik befassende Hauptteil gliedert sich in die Bereiche Schaedel, Wirbelsaeule, Brustkorb und Schulterguertel, obere Extremitaeten, Beckenguertel sowie untere Extremitaeten. (MG)

  15. Turbomachines. Fundamentals and applications. 3. new rev. ed.; Stroemungsmaschinen. Grundlagen und Anwendungen

    Energy Technology Data Exchange (ETDEWEB)

    Sigloch, H.

    2006-07-01

    This new textbook presents a concise and application-centered review of the field of turbo-engines. The book concentrates on the basic features common to all turbo-engines. Centrifugal pumps, which encountered everywhere in engineering practice, serve as a typical example of a turbo-machines. In the second part of the book, the various groups of turbo-machines are discussed separately. The book uses only standard formulas, symbols, and dimensions. Wherever possible, equations between quantities are used, i.e. equations that are independent of the system of units. In the interest of the learning reader, the author tries to use a standardized terminology and standardized notations. 70 exercises serve to sink in the subject matter and illustrate its practical applications. The book thus makes it easier for the student to gain access to the subject field and serves as a memory aid and practical guide for the practical engineer. The third edition is completed by a CDrom covering besides multimedial presentations (images, videos, animations) also the solution of the exercises from the book on PDF formate (orig./GL)

  16. Diagnostic imaging of the hand. 3. rev. and enl. ed.; Bildgebende Diagnostik der Hand

    Energy Technology Data Exchange (ETDEWEB)

    Schmitt, Rainer [Herz und Gefaessklinik GmbH, Bad Neustadt (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie; Lanz, Ulrich

    2015-07-01

    The book on diagnostic imaging of the hand covers the following issues: projection radiography, cinematography, MRT and CR arthrography, arthroscopy, arteriography, skeleton scintiscanning, sonography, computerized tomography, magnetic resonance tomography, anatomy of forearm and carpus, anatomy of metacarpus and fingers, carpal function and morphometry, postoperative X-ray diagnostic, growing hand skeleton, normative variants, malformations and deformities, trauma of the distal forearm, lesions of the ulnocarpal complex (TFCC), scaphoid fractures, scaphoid arthrosis, fractures of other carpus bones, carpal luxations and luxation fractures, carpal instabilities, fractures of the metacarpalla, finger fractures, arthrosis deformans, enthesiopathies, sport induced soft tissue lesions, osteonecrosis, impingement syndromes, osteopenic skeletal diseases, metabolis diseases, crystal-induced osteoarthropaties, rheumatoid arthritis, spondyloarthritis, rheumatic fever, collagenoses, infective arthritis, osteomyelitis, soft tissue infections, cystoids bone lesions, skeletal tumors, soft tissue tumors, carpal tunnel syndrome, nerve compression syndrome, arterial perfusion disturbances, differential diagnostic tables on hand lesions.

  17. MRT of the locomotor system. 4. rev. and enl. ed.; MRT des Bewegungsapparats

    Energy Technology Data Exchange (ETDEWEB)

    Vahlensieck, Martin [Praxisnetz Radiologie und Nuklearmedizin Bonn Bad Godesberg - RheinSieg, Bonn (Germany); Reiser, Maximilian (ed.) [Klinikum Grosshadern, Muenchen (Germany). Inst. fuer Klinische Radiologie

    2015-02-01

    The book on MRT of the locomotor system covers the following topics: relevant NMT imaging techniques, spinal cord, shoulder, elbows, wrist and fingers, hip region, knee, lower leg - ankle - foot, temporomandibular joint, skeletal muscles, bone marrow, bone and soft tissue tumors, osteoporosis, sacroiliac joint, jaw and periodontium.

  18. Photovoltaics. Solar power from the roof. 3. rev. ed.; Photovoltaik. Solarstrom vom Dach

    Energy Technology Data Exchange (ETDEWEB)

    Seltmann, Thomas

    2012-09-15

    The photovoltaics experiences a rapid technical development. The power plants become ever more favourable and better. The financial supports and legal frame conditions change. The compass with a solid knowledge from practice is all the more important. The main topics of this contribution are: (a) Meaningful planning of a solar power plant; (b) Securing financing - utilization of financial support; (c) Construction and plugging of a solar power plant; (d) Operation and maintenance of the own plant; economical calculation - questions on tax and legal aspects.

  19. Imaging of the head and neck. 2. rev. and enl. ed

    Energy Technology Data Exchange (ETDEWEB)

    Mafee, M.F.; Valvassori, G.E. [University of Illinois, Chicago, IL (United States); Becker, M. [Geneva University Hospital (Switzerland)

    2004-07-01

    Remarkable advances in medical diagnostic imaging have been made during the past three decades. The development of new imaging techniques and continuous improvements in the display of digital images have opened new horizons in the study of head and neck anatomy and pathology. The American Society of Head and Neck Radiology (ASHNR) and its European and Asiatic counterparts evolved because of the emerging awareness of the roles that head and neck radiologists play in the diagnosis and management of head and neck, base of the skull, neuro-ophthalmologic and neuro-otologic diseases. This edition continues the tradition of excellence set by the first edition of Valvassori's Head and Neck Imaging (which was also the first textbook in head and neck radiology), and provides a comprehensive review of the most pertinent and up-to-date knowledge in the field of head and neck imaging. The content of this edition has been organized into 12 chapters according to anatomic regions. It now includes new material on the temporomandibular joint, the lacrimal drainage system, dental scanning, fibro-osseous and cartilaginous lesions of the head and neck, MRI sialography, MR interventional technique, and thyroid and parathyroid glands. All chapters have been expanded to address new developments in the field and to stress the importance of imaging anatomy, pathologic correlation, and pertinent clinical data. For each anatomic region, the embryology and anatomy are introduced, followed by congenital and developmental disorders, inflammatory processes, benign and malignant neoplastic diseases, trauma, and postoperative changes. The detailed reference lists in each chapter include key references and are as recent as possible. Care has been taken to include exquisitely reproduced illustrations that provide the maximum of pertinent information. It is our hope that this textbook will be useful to students and physicians in the fields of radiology, otolaryngology, neurootology, rhinology, head and neck surgery, ophthalmology, neuroophthalmology, oromaxillofacial-temporomandibular surgery, neurology, neurosurgery, and oncology. (orig.)

  20. Bones - joints - soft tissues II. 7. rev. ed. Knochen - Gelenke - Weichteile II

    Energy Technology Data Exchange (ETDEWEB)

    Dihlmann, W. (Roentgeninstitut, Allgemeines Krankenhaus Barmbek, Hamburg (Germany)); Frommhold, W. (Radiologische Klinik, Tuebingen Univ. (Germany)) (eds.)

    1991-01-01

    With the publication of the 2nd part to Volume VI, 'Bones - joints - soft tissues', the 7th edition of 'Diagnostic radiology in the hospital and medical practice' is complete. The advances made particularly during the past decade in the field of diagnostic radiology have made it neccesary for all the individual sections to be completely revised. Recently developed methods of imaging like sonography, computed tomography and magnetic resonance tomography are increasingly used as a replacement for or, at least, an adjunct to conventional X-ray procedures. Owing to the development and continuous refinement of related methods of intervention the gap between mere diagnostic applications and therapeutic uses of radiology could eventually be closed. The issues mainly discussed in this volume are bone fractures and healing, bone transplantation, osteopathy and osteoarthropathy, fibrous dyplasia or Albright's disease, Pagetoid osteitis, genetically transmitted constitutional disorders of the skeleton and soft tissue changes. While in the key sections on bone fractures and healing, osteopathy and osteoarthropathy as well as constitutional genetic disorders X-ray techniques are still described as the prevailing method of diagnosis, diseases of soft tissues now are much more commonly diagnosed using magnetic resonance imaging. (orig./MG) With 2248 figs., 59 tabs.

  1. Bioenergy. The manifold renewable energy. 4. compl. rev. ed.; Bioenergie. Die vielfaeltige erneuerbare Energie

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-06-15

    Bioenergy is the most important renewable energy source in Germany. With about 70 percent bioenergy contributes to the largest share of energy supply from renewable energy sources. This brochure provides an overview of the various possibilities, advantages and opportunities in the use of biomass and bioenergy.

  2. High-resolution sonography of the peripheral nervous system. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Peer, Siegfried [Innsbruck Medical University (Austria). Section for Diagnostic and Interventional Sonography; Bodner, Gerd (eds.) [St. Bernards Hospital (Gibraltar)

    2008-07-01

    Since the first edition of this book, sonography of the peripheral nervous system has evolved further. Not only has knowledge of the sonographic features of common neurological disorders deepened, but constant research has led to the application of sonography in the diagnosis and guided treatment of disorders that were not previously accessible. This second, revised edition reflects these ongoing developments in various ways: many state of the art high-resolution images are included, the text has been adapted to reflect the current state of the literature, and information is presented using a more modern layout. Anatomic/sonographic correlation is considered in depth, and examination technique with modern sonography equipment is explained. This book provides a practical, clinically oriented overview of all aspects of sonographic diagnosis and interventional therapy of the peripheral nervous system and will be of value to all with an interest in this field. (orig.)

  3. Ocean storage of CO{sub 2}. 2nd rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Ormerod, W.G.; Freund, P.; Smith, A.; (comps.); Davison, J.

    2002-03-01

    Storing carbon dioxide (CO{sub 2}) in the oceans may provide a useful means of tackling climate change. This report explains the concept, provides a simple description of its scientific aspects and discusses the environmental implications. It also describes the further research that would be needed before this option for controlling the rise in atmospheric CO{sub 2} concentration could be implemented. The report concentrates on the capturing of CO{sub 2} from large industrial point sources and injecting it into the deep ocean. Most of the information given is derived from a series of workshops sponsored by the IEA Greenhouse Gas R & D Programme. Section headings are: introduction; natural carbon storage in the oceans; how do the oceans remove CO{sub 2} from the atmosphere?; is direct injection of CO{sub 2} a practicable proposition?; is ocean storage an expensive option?; impact on the marine environment; will storage of CO{sub 2} in the ocean be permitted?; priorities for further research; conclusions; appendix (describing the alternative sequestration strategy for ocean fertilisation). 26 refs., 7 figs., 2 tabs., 1 app.

  4. Fundamentals of electrical engineering; 5. tot. new rev. ed.; Grundlagen der Elektrotechnik

    Energy Technology Data Exchange (ETDEWEB)

    Pregla, R. [Fernuniversitaet (Gesamthochschule) Hagen (Germany). Fachbereich Elektrotechnik

    1998-10-01

    This is a textbook for the first two university terms in electrical engineering. Subjects: Description of physical processes; Static electric fields; Electric current; d.c. circuits; Calculation of linear networks; Magnetic fields; Electromagnetic induction; Electric circuits in the quasi-stationary state; Alternating currents and networks. To facilitate self-studies, the book is divided into 14 training lessons. (orig.) [Deutsch] Dieser Band enthaelt - analog zur Stoffvermittlung in den ersten beiden Studiensemestern - folgende inhaltliche Schwerpunkte: - Beschreibung physikalischer Vorgaenge - statisches elektrisches Feld - elektrischer Strom - Gleichstromschaltungen - Berechnung linearer Netzwerke - magnetisches Feld - elektromagentische Induktion - elektrischer Stromkreis im quasistationaeren Zustand - Wechselstroeme und Netzwerke. Fuer die autodidaktische Erarbeitung des Stoffes besonders vorteilhaft ist die Aufteilung der Inhalte in 14 Kurseinheiten, die jeweils mit einer Vororientierung beginnen. (orig./GL)

  5. Electrical engineering. An introduction. 17., rev. ed.; Theoretische Elektrotechnik. Eine Einfuehrung

    Energy Technology Data Exchange (ETDEWEB)

    Mathis, W. [Hannover Univ. (Germany). Inst. fuer Theoretische Elektrotechnik und Hochfrequenztechnik; Reibiger, A. [Technische Univ. Dresden (Germany). Inst. fuer Grundlagen der Elektrotechnik und Elektronik; Kuepfmueller, K.

    2006-07-01

    After the 16, revised edition, this 17th edition presents further innovations. The main part of the book deals with the theory and applications of electromagnetic fields. Approximation theories are classified: Theory of electrical networks, electrostatics, electric current fields, steady magnetic fields, quasisteady field, full Maxwell equations. The authors present a novel explanation of the field theory approach in physical modelling and in the theory of steady magnetic fields and quasisteady fields. The fundamentals of the theory of electric networks and transmission lines were updated according to the latest state of knowledge. The application of the methods is illustrated by examples. The authors took care to retain the clear and intelligible style of the first author, Kuepfmueller. (Sections 14.5 Electron Optics, 37.1 Electric currents in gases, 38 Electron tubes were left out of the book and are available for downloading in the internet.) (orig.) [German] Der Klassiker der ''Theoretischen Elektrotechnik'' wurde in der 16. Auflage vollstaendig neu bearbeitet und fuer die vorliegende 17. Auflage weiter verbessert. Der Hauptteil des Buches befasst sich mit der Theorie und einfuehrenden Anwendungen elektromagnetischer Felder. Es gibt eine klare Gliederung der Naeherungstheorien: Theorie elektrischer Netzwerke, Elektrostatik, elektrisches Stroemungsfeld, stationaeres Magnetfeld, quasistationaeres Feld, volle Maxwellsche Gleichungen. Die Autoren geben eine neuartige Begruendung des feldtheoretischen Ansatzes bei der physikalischen Modellbildung und der Theorie stationaerer Magnetfelder und quasistationaerer Felder. Auch die Grundlagen der Theorie elektrischer Netzwerke und der Theorie der Uebertragungsleitungen wurden auf den neuesten wissenschaftlichen Stand gebracht. In den Beispielen und Anwendungsabschnitten wird die Brauchbarkeit der abgehandelten Methoden demonstriert. Besonderen Wert haben die Autoren darauf gelegt, den kuepfmuellerschen Stil beizubehalten, der das Buch zu einem Bestseller gemacht hat. (Die eher in den Hintergrund getretenen Abschnitte 14.5 Elektronenoptik, 37.1 Stromleitung in Gasen, 38 Elektronenroehren wurden aus Umfangsgruenden aus dem Buch ausgelagert und stehen nun zusaetzlich als Download im Internet zur Verfuegung.) (orig.)

  6. Electrical engineering. Dictionary for practice. 2. rev. and enl. ed.; Elektrotechnik. Lexikon fuer die Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, R.

    2006-07-01

    About 2000 terms from the practice of electrical engineering are explained quickly and specified in this dictionary. Besides detailed illustrations of definitions, acronyms and formulas - obvious according to the actual national, European and international standards - it contains additively english expressions of important terms as hints on relating facts and further special literature. The dictionary, provided with many colored illustrations, offers a reliable aid for practitioners, planners, teachers and trainees. Furtheron it is a useful guide for students, masters and technicians during their education to an engineer with diploma. (GL)

  7. Refrigeration engineering. Electrical engineering and control engineering. 2. rev. and enl. ed.; Kaelteanlagentechnik. Elektro- und Steuerungstechnik

    Energy Technology Data Exchange (ETDEWEB)

    Schittenhelm, D.

    1999-07-01

    The book presents the fundamentals of electrical engineering and its applications in refrigeration technology in accordance with the training syllabuses for refrigeration engineers. Practical examples are presented. The second part of the book discusses control technology in refrigeration engineering with the intention of inducing the reader to develop control systems and to design them according to specifications. Basic knowledge in this field is presented, and the reader is enabled to project, read and assess control systems with different boundary conditions. [German] Aufgabe dieses Buches ist es, im ersten Teil die Grundlagen der Elektrotechnik bezogen auf die Anwendung im Kaelteanlagenbau darzustellen. Es orientiert sich dabei an den bestehenden Rahmenlehrplaenen fuer die Aus- und Weiterbildung von Kaelteanlagenbauern. Anhand von Praxisbeispielen wird die Anwendung des Grundlagenwissens verdeutlicht. Der zweite Teil des Buches beschaeftigt sich mit der Steuerungstechnik im Kaelteanlagenbau. Dabei will das Buch Akzente setzen, Steuerungen fuer Kaelteanlagen zu entwickeln und diese auch normgerecht darzustellen. Einen weiteren Schwerpunkt bildet das Lesen und Beurteilen von kaeltetechnischen Steuerungen. Auch hierfuer sind zunaechst Grundlagen erforderlich, die in diesem Buch vermittelt werden. Ausgehend von bestimmten Grundschaltungen wird der Leser in die Lage versetzt, Steuerungen mit anderen Randbedingungen projektieren, lesen und beurteilen zu koennen. (orig.)

  8. Electrical measurement and control engineering; 9. rev. ed.; Elektrische Mess- und Regelungstechnik

    Energy Technology Data Exchange (ETDEWEB)

    Boettle, P.; Boy, G.; Clausing, H.

    1998-10-01

    The book provides the knowledge required for training of master electricians (electricians, electromechanics, constructors of electrical machines in industry and trade). Basic mathematical and electrotechnical knowledge is required. Contents: General laws and definitions; Measurement of electrical vairables; Electricity meters; Measuring transformers; Recording meters; Electrical measurement of nonelectric variables; Oscilloscopes; Control engineering. (orig.) [Deutsch] Die behandelten Themen vermitteln das Wissen, das in der Meisterausbildung von Elektrikern der energietechnischen Berufe (Elektroinstallateur, Elektromechaniker, Elektromaschinenbauer im Handwerk und in der Industrie) gefordert wird. Die mathematischen und elektrotechnischen Grundlagen werden vorausgesetzt. - Allgemeine Bestimmungen und Grundbegriffe - Messung elektrischer Groessen - Elektrizitaetszaehler - Messwandler - schreibende Messgeraete - elektrische Messung nichtelektrischer Groessen - Oszilloskop - Regelungstechnik. (orig.)

  9. Introduction to DIN-standards. 14. new rev. ed.; Einfuehrung in die DIN-Normen

    Energy Technology Data Exchange (ETDEWEB)

    Klein

    2008-07-01

    The book presents a comprehensive introduction to DIN standards and their application. It considers production-related and functional aspects of the standard and offers detailed information that makes it a valuable reference manual for studies and practice. For the fields of mechanical engineering and electrotechnics, it provides first-hand information that is indispensable in construction and production. In many cases, references are made to related standards and relevant literature, and the context of European and international standards is presented. For the 14th edition, the standard work Klein DIN-Normen was revised and re-edited in order to keep up with the present state of standardisation. Contents: Standardisation; DIN standards; Application of standards; International, regional and European standards; Standards for consumers and environmental protection; Safety and health protection with standards; Production processes; Materials; Technical product documentation and technical drawing; Fundamentals of construction; Machine elements; Mechanical connecting elements; Welding, soldering, cutting and thermal spraying; Threads; Tolerances and fits; Technical surfaces; Corrosion protection; Materials testing; Electrical engineering; Mathematics, physics; Quality management, statistics, metrology; DIN standard committees; Materials; List of standards, with numbers; Subject index. (orig.)

  10. Biogas plants in EEG. 3. new rev. and enl. ed.; Biogasanlagen im EEG

    Energy Technology Data Exchange (ETDEWEB)

    Loibl, Helmut; Maslaton, Martin; Bredow, Hartwig von; Walter, Rene (eds.)

    2013-06-01

    EEG 2012 is a complete revision for new EEG plants whereby the previous requirements of the EEG 2009 can be maintained for the existing plants. The authors of the book under consideration fully focus on the splitting into two different legal systems and the implications. It describes possibilities of solution for problems from the daily practice. The book provides a complete commentation of the biomass ordinance as well as the statements on the connection to the gas grid of biomethane plants.

  11. Wood fuel from the agriculture. 5. rev. ed.; Energieholz aus der Landwirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Baerwolff, Manuela; Hansen, Hermann; Hofmann, Martin; Setzer, Frank

    2012-11-01

    The cultivation of fast-growing trees in short rotation is an extensive form of land use which appears thoroughly interesting in terms of climate change and the recent price development. In Germany cultivation concepts have to be oriented to the existing agricultural structure. It is a crucial requirement for the practical introduction of fast growing tree species to answer the following questions: (1) What should be considered in the cultivation?; (2) What types of trees are recommended?; (3) Which harvesting processes do exist?; (4) How does the economy present itself? The contribution under consideration attempts to answer these and other questions. The contribution summarizes the current state of knowledge from previous research and the first practical cultivations. The contribution is addressed to the practical farmer.

  12. Doppler ultrasound in obstetrics and gynecology. 2. rev. and enl. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Maulik, D. [Winthrop Univ. Hospital, Mineola, NY (United States). Dept. of Obstetrics and Gynecology; Zalud, I. (eds.) [Kapiolani Medical Center for Women and Children, Honolulu, HI (United States)

    2005-07-01

    The second edition of Doppler Ultrasound in Obstetrics and Gynecology has been expanded and comprehensively updated to present the current standards of practice in Doppler ultrasound and the most recent developments in the technology. Doppler Ultrasound in Obstetrics and Gynecology encompasses the full spectrum of clinical applications of Doppler ultrasound for the practicing obstetrician-gynecologist, including the latest advances in 3D and color Doppler and the newest techniques in 4D fetal echocardiography. Written by preeminent experts in the field, the book covers the basic and physical principles of Doppler ultrasound; the use of Doppler for fetal examination, including fetal cerebral circulation; Doppler echocardiography of the fetal heart; and the use of Doppler for postdated pregnancy and in cases of multiple gestation. Chapters on the use of Doppler for gynecologic investigation include ultrasound in ectopic pregnancy, for infertility, for benign disorders and for gynecologic malignancies. (orig.)

  13. Directory of German wind energy 1998; 3. rev. ed.; Adressbuch der Windenergie 1998

    Energy Technology Data Exchange (ETDEWEB)

    Strunk-Stueckemann, C. [ed.

    1998-06-01

    The 3rd edition of the DEWI German Directory of Wind Energy comprises information on the following topics: (a) Manufacturers and suppliers of wind energy converters and components; measuring equipment; (b) Public and commercial research organisations; (c) Engineering offices and consultants; (d) Banks and insurance companies; (e) Investment and operators companies; (f) Electric supply utilities; (g) Services; (h) Public relations and education; (i) Subject index in German and English. (AKF) [Deutsch] Die dritte Auflage des DEWI-Adressbuches 1998 beinhaltet Angaben zu den folgenden Themen: (a) Hersteller/Lieferer von: Windkraftanlagen und Komponenten; Messtechnik; (b) Oeffentliche und gewerbliche Forschung; (c) Enginieurbueros/Beratung; (d) Banken und Versicherungen; (e) Beteiligungs- und Betreibergesellschaften; (f) Energieversorgungsunternehmen; (g) Dienstleistungen; (h) Oeffentlichkeitsarbeit und Aus- und Weiterbildung; (i) Register (deutsch-englich). (AKF)

  14. Mobility with less gasoline consumption. A guide. 2. rev. ed.; Sprit sparen und mobil sein. Ratgeber

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-02-15

    This publication by the Federal Environmental Office contains information on how to save motor fuels when driving, how to use the motor car intelligently, and how to chose a new car for buying. Alternative options like public transportation are gone into as well. (orig.)

  15. Electrosmog. Health hazards, limit values, consumer protection; 4. rev. ed.; Elektrosmog. Gesundheitsrisiken, Grenzwerte, Verbraucherschutz

    Energy Technology Data Exchange (ETDEWEB)

    Karus, M.; Ebert, L.; Wilke, I.; Schneider, W.; Koehnecke, W.; Loefflad, H.; Plotzke, O.; Niessen, P.

    1997-07-01

    The book deals with ``electrosmog``, the electromagnetic fields in our environment that are generated by electrical equipment and installations and which are being studied more closely recently as a suspected source of a variety of health hazards or diseases. The initial chapter explains the physical fundamentals and terminology, the process and the sources generating the electrical and magnetic fields found in our environment, as well as the measuring techniques applied for detection and assessment. The following chapters present information on the state of the art in research into the health effects of electrosmog in the low and high-frequency ranges, on currently applicable limit values and the underlying concepts of calculation, as well as the policy pursued in this context. The concluding chapters of the book discuss the sources of electrosmog in a variety of living environments as well as mitigating or protective measures defined from the angle of consumer protection. (FK) [Deutsch] Dieses Buch befasst sich mit der unter dem Namen `Elektrosmog` bekannt gewordenen elektromagnetischen Umweltbelastung, die in juengster Zeit fuer eine Vielzahl von Krankheiten verantwortlich gemacht wird. Eingangs werden grundlegende physikalische Begriffe, das Auftreten von elektrischen und magnetischen Feldern im Alltag sowie die Messung von Elektrosmog behandelt. Das folgende Kapitel stellt den aktuellen Forschungsstand ueber die gesundheitlichen Auswirkungen von Elektrosmog im Nieder- und Hochfrequenzbereich dar. Anschliessend werden die derzeit gueltigen Grenzwerte und ihre konzeptionelle und politische Basis diskutiert. Der letzte Teil geht auf die vielfaeltigen Quellen von Elektrosmog in den unterschiedlichen Lebensbereichen ein und diskutiert Massnahmen fuer den Verbraucherschutz. (FK)

  16. Law of the energy economy. A practical manual. 4. new rev. ed.; Recht der Energiewirtschaft. Praxishandbuch

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Jens-Peter [Freiburg Univ. (Germany); Theobald, Christian (ed.)

    2013-07-01

    This manual presents the laws governing the electricity and gas markets, a field that has evolved at ever greater speed since the onset of liberalisation. Its content is of practical relevance and well-founded, yet nonetheless readily comprehensible to the layman. Following introductory sections on the technical and economic as well as national and European foundations of energy law are a wealth of contributions offering detailed analyses of the regulation of market structures; planning and licensing of energy infrastructure and energy installations; granting of municipal concessions to energy supply companies; trade in energy and emission permits as well as grid operation and grid utilisation; energy regulatory authorities and procedures; promotion of renewable energy, cogeneration and energy saving. The manual consistently takes account of the relevant regulations of cartel, municipal, environmental, tax, contractual and financial market law. Links to energy law proper are duly covered wherever practically relevant. The following legislation in particular has been incorporated in this new edition: 2011 amendment to the Energy Economy Law (unbundling, transmission system operator, grid development plans, modernisation in metrology, new consumer rights); 2012 amendment to the Nuclear Energy Law; Grid Expansion Acceleration and Transmission System Law of 2011 (NABEG); Renewable Energy Law of 2012; and Cogeneration Law of 2012.

  17. EEG. Renewables Act. Comment. 4. new rev. and enl. ed.; EEG. Erneuerbare-Energien-Gesetz. Kommentar

    Energy Technology Data Exchange (ETDEWEB)

    Frenz, Walter [RWTH Aachen Univ. (Germany). Lehr- und Forschungsgebiet Berg-, Umwelt- und Europarecht; Mueggenborg, Hans-Juergen [Technische Hochschule Aachen (Germany); Kassel Univ. (Germany); Cosack, Tilman [Hochschule Trier, Umwelt-Campus Birkenfeld (Germany). IREK - Inst. fuer das Recht der Erneuerbaren Energien, Energieeffizienzrecht und Klimaschutzrecht; Ekardt, Felix (ed.) [Forschungsstelle Nachhaltigkeit und Klimapolitik, Leipzig (Germany)

    2015-07-01

    Unlike any other Act, the Renewable Energy Sources Act (EEG) changes continuously. Recently it has been fundamentally transformed with the amendment 2014. Comprehensive, readable and practice-oriented. The proven Berliner comment EEG is your reliable companion through the new regulatory regime. All provisions of the EEG 2014 thorough and easy to understand commented by experts of the matter. 2. The EEG Amending Act of 29.6.2015 has already been considered. A detailed introduction and contributions to the relevant European law and the antitrust aspects of the renewable energy sources to guarantee you a broad understanding of the rules. Valuable background information you provide, the digressions of the most important renewable energy technologies, will explain the pictures thanks to numerous the scientific and technical foundations. Moreover you the construction law aspects in the construction of photovoltaic and wind turbines are explained clearly. [German] Wie kaum ein anderes Gesetz veraendert sich das Erneuerbare-Energien-Gesetz (EEG) laufend. Zuletzt wurde es mit der Novelle 2014 grundlegend umgestaltet. Umfassend, verstaendlich und praxisgerecht Der bewaehrte Berliner Kommentar EEG ist Ihr verlaesslicher Begleiter durch das neue Regelungsregime. Alle Vorschriften des EEG 2014 werden gruendlich und leicht verstaendlich von Kennern der Materie kommentiert. Das 2. EEG-Aenderungsgesetz vom 29.06.2015 ist bereits beruecksichtigt. Eine ausfuehrliche Einleitung sowie Beitraege zum einschlaegigen europaeischen Recht und zu den kartellrechtlichen Aspekten der erneuerbaren Energien verhelfen Ihnen zu einem breiten Verstaendnis der Vorschriften. Wertvolles Hintergrundwissen liefern Ihnen auch die Exkurse zu den wichtigsten Erneuerbare-Energien-Technologien, die Ihnen dank zahlreicher Abbildungen die naturwissenschaftlich-technischen Grundlagen erlaeutern. Zudem werden Ihnen die baurechtlichen Aspekte bei der Errichtung von Photovoltaik- und Windenergieanlagen uebersichtlich erklaert.

  18. Biogas. Plants, raw materials, products. 7. rev. ed.; Biogas. Pflanzen, Rohstoffe, Produkte

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-08-15

    In order to save fossil fuels and to stopp the climate change, a gradual shift to renewable energies is necessary. The federal government has aimed to a modern, environmental friendly, sustainable and secure energy supply by means of the expansion of renewable energies. Bioenergy plays a central role in the future. Biogas for renewable energies will play a special role. Biogas can be used for simultaneous production of electricity and heat, as a fuel and as a substitute for natural gas.

  19. Differential diagnosis of rheumatic illnesses. 4. compl. rev. and enl. ed.; Differenzialdiagnose rheumatischer Erkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Zeidler, Henning [Rheumatologikum Hannover (Germany); Michel, Beat [UniversitaetsSpital Zuerich, Zurich (Switzerland). Rheumaklinik und Inst. fuer Physikalische Medizin

    2009-07-01

    The number of the possible differential diagnosis of rheumatic illnesses is extraordinarily high. This circumstance makes the diagnostics a difficult field with numerous pitfalls. The correct and complete diagnosis however is a condition for the correct therapy. This book facilitates this way from the symptom to the diagnosis for the reader: A detailed representation of the fundamentals (anamnesis, investigation findings, laboratory diagnostics and imaging) a detailed description of all important differential diagnosis follows. The meanwhile fourth edition of this standard work was completely revised and updated. An indispensable guide book for all persons which treat patients with rheumatic illnesses. [German] Die Zahl der moeglichen Differenzialdiagnosen rheumatischer Erkrankungen ist ausserordentlich hoch. Dieser Umstand macht die Diagnostik zu einem schwierigen Feld mit zahlreichen Fallstricken. Die korrekte und vollstaendige Diagnose ist aber Voraussetzung fuer die richtige Therapie. Dieses Buch erleichtert dem Leser diesen Weg vom Symptom zur Diagnose: Einer ausfuehrlichen Darstellung der Grundlagen (Anamnese, Untersuchungsbefund, Labordiagnostik und Bildgebung) folgt eine detaillierte Beschreibung aller wichtigen Differenzialdiagnosen. Die mittlerweile vierte Auflage dieses Standardwerks wurde komplett ueberarbeitet und aktualisiert. Ein unverzichtbarer Ratgeber fuer alle, die Patienten mit Erkrankungen aus dem rheumatologischen Formenkreis behandeln. (orig.)

  20. Dubbel. Handbook for mechanical engineering; 19. completely rev. ed.; Dubbel. Taschenbuch fuer den Maschinenbau

    Energy Technology Data Exchange (ETDEWEB)

    Beitz, W. [Technische Univ. Berlin (Germany); Grote, K.H. [eds.] [Magdeburg Univ. (Germany)

    1997-12-31

    The book is a textbook as well as as a handy source of reference offering a wealth of both fundamental and in-depth information relating to the subject fields of: Mathematics; mechanics; strength of materials; thermodynamics; materials technology; engineering design; mechanical machine components; hydraulic and pneumatic power transmission; electronic components; components of thermal apparatus; energy systems; HVAC engineering; process engineering; machine dynamics; reciprocating engines; automotive technology; fluid flow machines (turbomachinery); manufacturing processes; manufacturing systems; materials handling and conveying; electrical engineering; metrology; automatic control; electronic data processing. (orig./GL) [Deutsch] Nicht nur als Lehrmittel, sondern auch als Nachschlagewerk stellt das Buch das Basis- und Detailwissen der folgenden Gebiete bereit: - Mathematik - Mechanik - Festigkeitslehre - Thermodynamik - Werkstofftechnik - Konstruktionstechnik - mechanische Konstruktionselemente - fluidische Antriebe - elektronische Konstruktionskomponenten - Komponenten des thermischen Apparatebaus - Energietechnik - Klimatechnik - Verfahrenstechnik - Maschinendynamik - Kolbenmaschinen - Stroemungsmaschinen - Kraftfahrzeugtechnik - Fertigungsverfahren - Fertigungsmittel - Foerdertechnik - Elektrotechnik - Messtechnik - Regelungstechnik - elektronische Datenverarbeitung. (orig./GL)

  1. Acid rain and forest decline. 3. rev. ed. Saurer Regen und Waldsterben; Unterrichtsmaterialien

    Energy Technology Data Exchange (ETDEWEB)

    Kues, J.; Matzner, E.; Murach, D.; Blanck, K.

    1991-01-01

    These materials for sixth-form education and adult education provide information on emissions of SO[sub 2], NO[sub x] and heavy metals and their propagtaion, as well as on the formation of oxidants and other chemical conversion processes in the atmosphere. The pathway of the pollutants is followed up, via their atmospheric transport in their deposition on plants and soil, including forms and rates of deposition, and further to their direct and indirect effects on forest ecosystems and their elements. Effects on leaves, buffering of acids and soil acidification, and hazards to ground water are described; the physiological consequences of heavy-metal release in soil on roots and overground organs are explained. The kinetic of the effect of pollutants is followed up and its interaction with other stress factors discussed. Finally, suitable counter-measures are presented. (UWA)

  2. Quantum physics for dummies. 2. rev. and enl. ed.; Quantenphysik fuer Dummies

    Energy Technology Data Exchange (ETDEWEB)

    Holzner, Steven

    2012-07-01

    Quantum physics is a central and fascinating, albeit unpopular by many students theme of physics. Steven Holzner explains understandably and alively, what must be known about quantum physics. He explains the foundations of angular momentum and spin, gives tips how complex equations can be solved. Thereby he works with examples, which he explains extensively.

  3. Biogas plants in EEG. 4. new rev. and enl. ed.; Biogasanlagen im EEG

    Energy Technology Data Exchange (ETDEWEB)

    Loibl, Helmut; Maslaton, Martin; Bredow, Hartwig von; Walter, Rene (eds.)

    2016-08-01

    With the EEG 2014, the legislature has created a complete revision of all the RES plants. Specifically for biogas plants fundamental changes have been made with the maximum rated power or a new landscape conservation concept. For new biogas plants the legislator arranges not only a much lower remuneration, but also the direct marketing as a rule, which entails fundamental changes in the overall compensation system by itself. The new edition of this highly regarded standard work revives the extensive practical experience to EEG 2009, 2012 and 2014 in detail and in particular and takes into account the large number of newly issued clearinghouses decisions and judgments. All current legal issues and challenges of biogas plants can be found comprehensively presented here. [German] Mit dem EEG 2014 hat der Gesetzgeber eine komplette Neuregelung fuer alle EEG-Anlagen geschaffen. Speziell fuer Biogasanlagen wurden mit der Hoechstbemessungsleistung oder einem neuen Landschaftspflegebegriff grundlegende Aenderungen vorgenommen. Fuer neue Biogasanlagen ordnet der Gesetzgeber nicht nur eine deutlich geringere Verguetung, sondern zudem die Direktvermarktung als Regelfall an, was grundlegende Veraenderungen des gesamten Verguetungssystems nach sich zieht. Die Neuauflage dieses vielbeachteten Standardwerks greift die umfangreichen Praxiserfahrungen zum EEG 2009, 2012 und 2014 detailliert auf und beruecksichtigt insbesondere auch die Vielzahl der neu ergangenen Clearingstellenentscheidungen und Urteile. Alle aktuellen rechtlichen Themen und Herausforderungen bei Biogasanlagen finden Sie hier umfassend dargestellt.

  4. Electric batteries and the environment. 2. rev. and enlarged ed. Die Batterie und die Umwelt

    Energy Technology Data Exchange (ETDEWEB)

    Hiller, F.; Hartinger, L.; Kiehne, H.A.; Niklas, H.; Schiele, R.; Steil, H.U.

    1990-01-01

    The book deals with the prodution, use and waste management of batteries (accumulators and primary batteries), with regard to protection of the environment. Legal, technical and medical aspects are shown. Subjects: 1. Toxicological aspects of battery substances; 2. legal foundations of environmental protection; 3. off-air purification in battery production; 4. dust monitoring; 5. waste water of the battery industry; 6. safety aspects of battery operation; 7. recycling of battery materials; 8. disposal of used primary batteries. (orig./MM) With 67 figs.

  5. It comes with the territory handling problem situations in libraries, rev ed

    CERN Document Server

    Turner, Anne M

    2004-01-01

    ""Practical...useful""--Booklist; ""order this book immediately...interesting...entertaining and educational...outstanding...timely and useful--a must for all sizes and types of libraries""--Library Journal; ""good...recommended""--Public Libraries; ""Turner has revised and updated this classic guidebook that provides creative and sensible ways for handling sticky situations in public libraries""--SRRT Newletter; ""highly recommended""--Public Services Quarterly; ""well written...engaging...very helpful and timely""--Reference Quarterly

  6. Albert Einstein for beginners. 12. enl. and rev. ed.; Albert Einstein fuer Anfaenger

    Energy Technology Data Exchange (ETDEWEB)

    Karamanolis, Stratis

    2008-07-01

    He was called the most important jew since the birth of Christus. Others however believed however he has came like no other nearer to the gods. Thought is Albrt Einstein, the scientific work of him and especially his relativity theory has the world changed radically both in scientific and in political regard. The present 12th extended and strongly revised edition of the book, which came out firstly above 20 years ago and until today thousands of readers - young and old - has always enthused, describes not only the relativity theory but also the role, which Einstein played in the development of the first atomic bomb. A short biographical part mediates to the reader also something about the man Einstein.

  7. EEG. Renewables Act. Comment. 3. new rev. and enl. ed.; EEG. Erneuerbare-Energien-Gesetz. Kommentar

    Energy Technology Data Exchange (ETDEWEB)

    Frenz, Walter [Rheinisch-Westfaelische Technische Hochschule (RWTH), Aachen (Germany). Lehr- und Forschungsgebiet Berg-, Umwelt- und Europarecht; Mueggenborg, Hans-Juergen (eds.) [Kassel Univ. (Germany)

    2013-05-01

    Like hardly any other law, the Renewable Energy Sources Law (EEG) is a subject to continuing modifications. This makes the application of the already complicated regulations even for experts to a special challenge. With the proven Berliner comment EEG, now a reliable companion through the bureaucratic jungle is available. All regulations of the EEG are commented precisely and easily to understand by profound experts. An extensive selection of terminology enables a rapid orientation within this book. In addition to the excursions to renewable energy technologies, this book also describes the structural aspects in the establishment of a photovoltaic system.

  8. Fuel cells. Development, technology, application. 2. new rev. and enl. ed.; Brennstoffzellen. Entwicklung, Technologie, Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Ledjeff-Hey, K.; Mahlendorf, F.; Roes, J. [eds.

    2001-07-01

    The book reviews the state of the art of fuel cells: General aspects; State incentives for fuel cell projects; Alkaline fuel cells; Polymer membrane fuel cell systems; Direct methanol fuel cells; The Vaillant PEM fuel cell heater; Cogeneration systems with fuel cells - results of a 5-year trial of 200 kW PAFC systems; PAFC plants in Japan; The MTU direct fuel cell hot module (MCFC); Plant conceptions and economic efficiency of SOFC power plants; The Sulzer Hexis project: Low-capacity SOFC technology; Low-capacity fuel cell systems - portable applications and battery replacement. [German] Dieses Buch gibt einen Ueberblick ueber den aktuellen Stand der Brennstoffzellen. Die zwoelf Kapitel lauten wie folgt: Brennstoffzellen - ein Ueberblick; Foerderung der Brennstoffzellentechnik; Alkalische Brennstoffzellen; Polymermembran-Brennstoffzellen-Systeme; Direkt-Methanolbrennstoffzellen; Das Vaillant PEM-Brennstoffzellen-Heizgeraet; Kraft-Waerme-Kopplung mit Brennstoffzellen - Erfahrungen aus ein 5-jaehrigen Versuchsbetrieb mit 200 kW-PAFC-Anlagen; PAFC Plants in Japan; Das MTU Direkt-Brennstoffzellen Hot Module (MCFC); Anlagenkonzeptionen und Wirtschaftlichkeit von SOFC-Kraftwerken; Das Projekt Sulzer Hexis - SOFC-Technologie fuer kleine Leistungen; Brennstoffzellen im kleinen Leistungsbereich - portable Anwendungen und Batterieersatz.

  9. MRT of the locomotor system. 3. tot. rev. and enl. ed.; MRT des Bewegungsapparats

    Energy Technology Data Exchange (ETDEWEB)

    Vahlensieck, M. [Univ. Muenchen-Grosshadern (Germany). Klinische Radiologie; Reiser, M. (eds.) [Radiologie Haydnhaus, Bremen (Germany)

    2006-07-01

    Diseases of the skeleton and soft tissues are the most common indications of MRT, second only to diseases of the central nervous system. This book contains all information that is required for rational diagnostic planning, for achieving optimum image quality, and for differential diagnosis. The clasification is didactically consequent and enables fast access to relevant details and practical information. Each chapter contains MR examination protocols, MR images of normal anatomic findings, pathological findings,post-therapeutic findings, potential errors in image interpretation, and information on the diagnostic value as compared to other imaging techniques. This is the second, completely revised and re-edited edition. Its more than 650 pages contain about 1500 high-quality images that answer all questions concerning MRT of the locomotor system and make the book a reference manual for all German-speaking countries that should not be missing in any place of work. (orig.)

  10. Wind energy utilisation. 7. enl. and compl. rev. ed.; Nutzung der Windenergie

    Energy Technology Data Exchange (ETDEWEB)

    Heier, Siegfried [Kassel Univ. (Germany)

    2016-07-01

    The use of wind energy register furthermore rapid technological advances. Intensive research efforts in scientific institutions and in industry have led to it that the plants are reliable high technology products today. An overview of these developments give the completely revised BINE reference-book. The focus is on technologies, concepts and the market development of the wind industry. Other topics include network integration, economy and current research perspectives as well as environmental balance and repowering. Planners, investors and students get an overview of the status and development of the technology, the economy and the legal framework. [German] Die Nutzung der Windenergie verzeichnet weiterhin rasante technologische Fortschritte. Intensive Forschungsanstrengungen an wissenschaftlichen Institutionen und in der Industrie haben dazu gefuehrt, dass die Anlagen heute zuverlaessige Hightech Produkte sind. Einen Ueberblick ueber diese Entwicklungen gibt das vollstaendig ueberarbeitete BINE-Fachbuch. Im Mittelpunkt stehen Technologien, Konzepte und die Marktentwicklung der Windbranche. Weitere Themen sind die Netzintegration, Wirtschaftlichkeit und aktuelle Forschungsperspektiven sowie Umweltbilanz und Repowering. Planer, Investoren und Studierende erhalten einen Ueberblick ueber Stand und Entwicklung der Technik, die Wirtschaftlichkeit sowie die rechtlichen Rahmenbedingungen.

  11. Physics for physicians; 2. rev. and enl. ed.; Physik fuer Mediziner

    Energy Technology Data Exchange (ETDEWEB)

    Kamke, D. [Bochum Univ. (Germany); Walcher, W. [Marburg Univ. (Germany)

    1994-12-31

    The book is based on lectures read by the authors at medical schools and tailored towards the specific requirements of medical students through a careful selection of subjects, special attention to pertinent medical aspects as well as examples and calculations throwing light on the question of quantity. The book wants to provide insights into the links between physics and some domains of biology and medicine and lead to a better understanding of the magnitudes involved. Being a textbook on physics, the book has adopted the methodology of this science in that results obtained through experimental work are verbally described and closely defined in order to set up rules which would finally permit quantitative determinations to be made on the basis of arithmetic laws. The divisions in this book were made according to a system slightly different from that usually followed. Phenomena of a similar nature are dealt with simultaneously and particular emphasis is placed on an atomistic approach to the problems dealt with. One chapter, ``Physical Principles Underlying the Methods of Medical Imaging`` (X-ray CT, radionuclide procedures, nmr imaging, sonographic), has been added altogether. (orig./HP) [Deutsch] Das Buch ist aus Vorlesungen entstanden, die die Verfasser an ihren Hochschulen speziell fuer angehende Mediziner gehalten haben und die auf deren besondere Beduerfnisse abgestellt waren: durch geeignete Stoffauswahl, durch Betonung medizinischer Aspekte sowie durch Beispiele und Rechenaufgaben, die ans Quantitative heranfuehren. So wil dieses Buch dem Leser Einsicht in die Verknuepfung der Physik mit biologisch-medizinischen Teilbereichen geben und ein Gefuehl fuer die dabei vorkommenden Gruessenordnungen vermitteln. Das Buch ist ein Lehrbuch der Physik, das der Methode der Physik folgt und vom experimentell erarbeiteten und mit Worten beschriebenen Sachverhalt zum exakt definierten Begriff kommt, mit solchen Begriffen Gesetze formuliert, die mit Hilfe der Regeln der Mathematik die Berechnung von Quantitaeten ermoeglichen. Im Buch sind das Gesamtgebiet der Physik etwas anders als herkoemmlich aufgeteilt, gleichartige Erscheinungen zusammengefasst, vor allem aber die atomistische Betrachtungsweise in den Vordergrund gestellt. Neu aufgenommen wurde das Kapitel ``Physikalische Grundlagen bildgebender Verfahren der Medizin`` (Roentgen-CT, Szintigraphie, Kernspin-Tmographie, Sonographie). (orig./HP)

  12. Manual for the energy trade. 3. new rev. and enl. ed.; Handbuch Energiehandel

    Energy Technology Data Exchange (ETDEWEB)

    Schwintowski, Hans-Peter (ed.) [Humboldt-Universitaet, Berlin (Germany)

    2014-07-01

    This manual sheds a light on the energy trade from both a legal and an empirical economic perspective. Its focus is on those business fields within the energy trade that are of foremost practical relevance, namely the OTC trade and the exchange trade. It also provides concise coverage of risk management systems in the energy trade along with a competent account of their implications with regard to supervisory regulations. In this, its third edition the manual addresses the latest developments in both the national and the international energy trade, including those seen in the gas storage market and its market access regulations; consideration is here also given to market transparency, market distortion and liquidity. The commentary on standard contracts (EFET) has been updated. The manual also addresses the adaptations made in the minimum requirements for risk management.

  13. Check list Doppler and duplex sonography. 4. rev. ed.; Checkliste Doppler- und Duplexsonografie

    Energy Technology Data Exchange (ETDEWEB)

    Kopp, Helmut [MED-Facharztzentrum, Mainz (Germany). Praxis fuer Gefaessmedizin; Ludwig, Malte [Benedictus Krankenhaus Tutzing (Germany). Gefaesszentrum

    2012-11-01

    Check list Doppler and duplex sonography includes 4 parts: (1) Basic information: technical fundamentals, equipment premises, hemodynamics. (2) Flow schemata and pitfalls. (3) Special vascular regions: arteries in the upper and lower extremities, veins in the upper and lower extremities, abdominal arteries, abdominal veins, ex-cranial brain sustaining arteries, intra-cranial brain sustaining arteries. (4) Attachment: diagnostic criteria and case studies.

  14. Differential diagnosis in computerized tomography. 2. rev. and enl. ed.; Differenzialdiagnosen in der Computertomografie

    Energy Technology Data Exchange (ETDEWEB)

    Burgener, Francis A.; Meyers, Steven P. [Rochester Univ., NY (United States). Dept. of Imaging Sciences; Herzog, Christopher [Rotkreuzklinikum Muenchen (Germany); Zaunbauer, Wolfgang [Kantonsspital St. Gallen (Switzerland). Inst. fuer Radiologie

    2013-02-01

    The book on differential diagnosis in computerized tomography is aimed to support radiologists and physicians with experience concerning the interpretation of computerized tomography images by detailed descriptions of CT diagnoses. The book covers the following topics: intracranial indications, head and neck, spinal cord, muscle-skeleton system, thorax, abdomen and pelvis.

  15. Radiology trainer. Surgical ambulance. 2. rev. and enl. ed.; Roentgen-Trainer. Chirurgische Ambulanz

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, Ole [Wedau-Kliniken Duisburg (Germany). Klinik fuer Unfallchirurgie; Ruchholtz, Steffen [Universitaetsklinikum Giessen und Marburg GmbH, Marburg (Germany). Klinik fuer Unfall-, Hand- und Wiederherstellungschirurgie; Siemann, Holger [LVR Klinikum Essen (Germany); Barkhausen, Joerg [Universitaetsklinikum Schleswig-Holstein, Luebeck (Germany). Klinik fuer Radiologie und Nuklearmedizin

    2013-08-01

    The radiology trainer for surgical ambulance includes informative X-ray imaging examples for the following issues: zygoma, nasal bone, spinal cord, clavicle, shoulder, upper arms, elbow, forearms, wrist, hand, phalanx, thorax, sternum, pelvis, abdomen, hips, femur, knee, lower leg, ankle, feet.

  16. MRT of the central nervous system. 2. rev. and enl. ed.; MRT des Zentralnervensystems

    Energy Technology Data Exchange (ETDEWEB)

    Forsting, Michael [Universitaetsklinikum Essen (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie und Neuroradiologie; Jansen, Olav (ed.) [Universitaetsklinikum Schleswig-Holstein, Kiel (Germany). Klinik fuer Radiologie und Neuroradiologie

    2014-11-01

    The book on MRT of the central nervous system includes the following chapters: anatomy, vascular diseases, brain tumors, craniocerebral injuries, infectious diseases, multiple sclerosis and related diseases, metabolic diseases, degenerative diseases, malformations and developmental disorders, hydrocephalus and intracranial hypertension, spinal marrow, degenerative caused spinal and foraminal stenosis, traumata, tumors and tumor-like neoplasm, vascular diseases, inflammations, infections and related diseases, diseases of the peripheral nervous system.

  17. Transesophageal echocardiography. 3. rev. and enl. ed.; Transoesophageale Echokardiografie. Lehrbuch und Altlas zur Untersuchungstechnik und Befundinterpretation

    Energy Technology Data Exchange (ETDEWEB)

    Lambertz, Heinz [ECHOECUCT-Akademie, Wiesbaden (Germany); Lethen, Harald (eds.) [Internistische Intensivmedizin, Wiesbaden (Germany). Innere Medizin/Kardiologie

    2013-02-01

    The book on transesophageal echocardiography covers the following issues: Development of transesophageal echocardiography, technical advances; indications and contraindication for transesophageal echocardiography; systematic of the medical examination process; cardiac valves and valve prostheses; mitral and aortic valvuloplasty, TAVI and interventional treatment of mitral regurgitation; infectious endocarditis; one-way and effluence disturbances of the left and right ventricle; diseases of the thoracic aorta; undefined right ventricle enlargement; lung embolism, acute infarct complications; TEE during anesthesia and perioperative intensive medicine, cardiac sources of embolism; cardiac tumors, mediastinal lymph nodes; pericardiac diseases; congenital heart diseases in childhood and adulthood; catheter interventions and heart valve reconstruction; surgically corrected congenital cardiac defects; intracavitary versus transesophageal echocardiography; three-dimensional TEE; coronary diagnostics; ischemia and vitality diagnostics.

  18. Materials flow systems. Haulage- and storage technology. 3. new rev. ed.; Materialflusssysteme. Foerder- und Lagertechnik

    Energy Technology Data Exchange (ETDEWEB)

    Hompel, Michael ten; Juenemann, Reinhardt (eds.); Schmidt, Thorsten; Nagel, Lars [Fraunhofer-Institut fuer Materialfluss und Logistik (IML), Dortmund (Germany)

    2007-07-01

    This basic textbook of intralogistics focuses on material flow systems as a symbiosis of in-house organisation and its physical implementation. There are many tables, graphs and technical data, as well as a multitude of examples and options that give the reader a comprehensive survey of the key components of transport and storage techniques. To design efficient material flow systems, one must have knowledge of the state of the art of currently available technologies for material flow operations and their interactions in the many envisageable applications. The book is a decision aid for students, practicians, planners and decision-makers. There is also an introduction to the design and analytical calculation of material flow systems that provides a comprehensive outline of the available components for meeting the central logistic functions of storage, transport, joining of material flow, and distribution. (orig.) [German] Materialflusssysteme als Symbiose aus betrieblicher Organisation und physischer, foerdertechnischer Umsetzung stehen im Mittelpunkt dieses Grundlagenwerks der Intralogistik. Zahlreiche Tabellen, Grafiken und technische Daten sowie eine Fuelle von Systembeispielen und Auswahlmoeglichkeiten liefern dem Leser einen vollstaendigen Ueberblick ueber die wesentlichen Komponenten der Foerder- und Lagertechnik. Die Gestaltung effizienter Materialflusssysteme setzt Kenntnisse ueber den Stand der heute verfuegbaren Technologien fuer die vielfaeltigen Materialflussoperationen und deren Wechselwirkungen in den zahlreichen Anwendungen voraus. Beim Abwaegen der grossen Auswahl an Gestaltungsmoeglichkeiten, die aus den vielen Technologien hervorgeht, steht dieses Buch sowohl Studierenden als auch Praktikern, Planern und Entscheidern zur Seite. Eine Einfuehrung in die Planung und analytische Berechnung von Materialflusssystemen vervollstaendigt den grundlegenden Ueberblick ueber die Komponenten zur Erfuellung der zentralen logistischen Funktionen, Dinge zu lagern, zu transportieren, zusammenzufuehren und zu verteilen. (orig.)

  19. Physics and radiology for the nursing professions. 4. rev. ed. Physik und Strahlenkunde fuer Krankenpflegeberufe

    Energy Technology Data Exchange (ETDEWEB)

    Goretzki, G. (Gemeinschaftspraxis Radiologie/Nuklearmedizin Dres. Stuckenholz, Ritter, Urban, Goretzki, Bielefeld (Germany))

    1991-01-01

    The development of new methods and equipment also brings about in medicine continuous changes. To be mentioned here in the field of diagnotics is nuclear magnetic resonance imaging. The amendment of the Radiation Protection Ordinance of 1989 also made it necessary to revise appropriate chapters of this book. (orig.) With 119 figs.

  20. Wood production for energy purposes in the agriculture. 4. rev. ed.; Energieholzproduktion in der Landwirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, Martin [Kompetenzzentrum HessenRohstoffe (HeRo) e.V., Witzenhausen (Germany)

    2010-07-01

    The cultivation of fast growing tree species such as poplars or willows in short harvesting periods is an extensive form of land use which increasingly is interesting with respect to the climate protection and development of the prices for fossil energy sources. Cultivation concepts have to be oriented towards the existing agrarian structure and the possible lines of utilization. This requires an answer of the following questions: (a) What has to be considered with the cultivation?; (b) Which tree species are recommended?; (c) Which procedures of harvesting do exist?; (d) How does economy present itself? The contribution under consideration tries to give answers to these questions. The contribution summarizes the actual state of knowledge from research and first practical cultivations. The contribution under consideration also dedicates itself to the practical farmer.

  1. Combined scintigraphic and radiographic diagnosis of bone and joint diseases. 3. rev. and enl. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong-Whee [Sung Ae General Hospital, Seoul (Korea). Dept. of Nuclear Medicine and Radiology

    2007-07-01

    The third edition of Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases has been comprehensively rewritten and rearranged. It now encompasses, in addition to the bone and joint diseases described in the two earlier editions, hitherto unpublished novel applications of pinhole scanning to the diagnosis of a broader spectrum of skeletal disorders than ever before, including those of the soft tissues. A large number of state-of-the-art scans and corroboratory images obtained using CT, MRI and/or sonography are presented side by side. The book has been considerably expanded to discuss five new themes: Normal Variants and Artifacts, Drug-Induced Osteoporosis, Soft-Tissue Tumors and Tumor-like Conditions, PET/CT in Bone and Joint Diseases and A Genetic Consideration of Skeletal Disorders. Topical chapters on rheumatic skeletal disorders, malignant tumors of bone, benign tumors of bone and traumatic diseases have also been thoroughly rewritten and are complemented by the addition of some 90 recently acquired cases. (orig.)

  2. Rev Variation during Persistent Lentivirus Infection

    Directory of Open Access Journals (Sweden)

    Karin S. Dorman

    2011-01-01

    Full Text Available The ability of lentiviruses to continually evolve and escape immune control is the central impediment in developing an effective vaccine for HIV-1 and other lentiviruses. Equine infectious anemia virus (EIAV is considered a useful model for immune control of lentivirus infection. Virus-specific cytotoxic T lymphocytes (CTL and broadly neutralizing antibody effectively control EIAV replication during inapparent stages of disease, but after years of low-level replication, the virus is still able to produce evasion genotypes that lead to late re-emergence of disease. There is a high rate of genetic variation in the EIAV surface envelope glycoprotein (SU and in the region of the transmembrane protein (TM overlapped by the major exon of Rev. This review examines genetic and phenotypic variation in Rev during EIAV disease and a possible role for Rev in immune evasion and virus persistence.

  3. HIV Rev Assembly on the Rev Response Element (RRE: A Structural Perspective

    Directory of Open Access Journals (Sweden)

    Jason W. Rausch

    2015-06-01

    Full Text Available HIV-1 Rev is an ~13 kD accessory protein expressed during the early stage of virus replication. After translation, Rev enters the nucleus and binds the Rev response element (RRE, a ~350 nucleotide, highly structured element embedded in the env gene in unspliced and singly spliced viral RNA transcripts. Rev-RNA assemblies subsequently recruit Crm1 and other cellular proteins to form larger complexes that are exported from the nucleus. Once in the cytoplasm, the complexes dissociate and unspliced and singly-spliced viral RNAs are packaged into nascent virions or translated into viral structural proteins and enzymes, respectively. Rev binding to the RRE is a complex process, as multiple copies of the protein assemble on the RNA in a coordinated fashion via a series of Rev-Rev and Rev-RNA interactions. Our understanding of the nature of these interactions has been greatly advanced by recent studies using X-ray crystallography, small angle X-ray scattering (SAXS and single particle electron microscopy as well as biochemical and genetic methodologies. These advances are discussed in detail in this review, along with perspectives on development of antiviral therapies targeting the HIV-1 RRE.

  4. Revised Safety Instruction 4 (IS4 REV.)

    CERN Multimedia

    2006-01-01

    Please note that the revised safety instruction 4 (IS4 REV.) entitled 'Safety Inspections' is available on the web at the following url: https://edms.cern.ch/file/335741/LAST_RELEASED/E_IS4.pdf Paper copies can also be obtained from the SC unit secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  5. Thermodynamics of Rev-RNA interactions in HIV-1 Rev-RRE assembly.

    Science.gov (United States)

    Jayaraman, Bhargavi; Mavor, David; Gross, John D; Frankel, Alan D

    2015-10-27

    The HIV-1 protein Rev facilitates the nuclear export of intron-containing viral mRNAs by recognizing a structured RNA site, the Rev-response-element (RRE), contained in an intron. Rev assembles as a homo-oligomer on the RRE using its α-helical arginine-rich-motif (ARM) for RNA recognition. One unique feature of this assembly is the repeated use of the ARM from individual Rev subunits to contact distinct parts of the RRE in different binding modes. How the individual interactions differ and how they contribute toward forming a functional complex is poorly understood. Here we examine the thermodynamics of Rev-ARM peptide binding to two sites, RRE stem IIB, the high-affinity site that nucleates Rev assembly, and stem IA, a potential intermediate site during assembly, using NMR spectroscopy and isothermal titration calorimetry (ITC). NMR data indicate that the Rev-IIB complex forms a stable interface, whereas the Rev-IA interface is highly dynamic. ITC studies show that both interactions are enthalpy-driven, with binding to IIB being 20-30 fold tighter than to IA. Salt-dependent decreases in affinity were similar at both sites and predominantly enthalpic in nature, reflecting the roles of electrostatic interactions with arginines. However, the two interactions display strikingly different partitioning between enthalpy and entropy components, correlating well with the NMR observations. Our results illustrate how the variation in binding modes to different RRE target sites may influence the stability or order of Rev-RRE assembly and disassembly, and consequently its function.

  6. Quicklook overview of model changes in Melcor 2.2: Rev 6342 to Rev 9496

    Energy Technology Data Exchange (ETDEWEB)

    Humphries, Larry L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    MELCOR 2.2 is a significant official release of the MELCOR code with many new models and model improvements. This report provides the code user with a quick review and characterization of new models added, changes to existing models, the effect of code changes during this code development cycle (rev 6342 to rev 9496), a preview of validation results with this code version. More detailed information is found in the code Subversion logs as well as the User Guide and Reference Manuals.

  7. Revised Safety Instruction 41 (IS41 REV.)

    CERN Multimedia

    SC Secretariat

    2005-01-01

    Please note that the Revised Safety Instruction No. 41 (IS41 REV.), entitled 'The use of plastic and other non-metallic materials at CERN with respect to fire safety and radiation resistance' is available on the web at the following url: https://edms.cern.ch/document/335806/LAST_RELEASED Paper copies can also be obtained from the SC Unit Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  8. Rebooting the EdD

    Science.gov (United States)

    Wergin, Jon F.

    2011-01-01

    In this essay, Jon Wergin reminds readers of the philosophical and historical foundations of the doctor of education (EdD) degree. He argues that the EdD should be based, in large part, on John Dewey's progressive ideals of democratization and Paulo Freire's concepts of emancipatory education. Drawing on theories of reflective practice,…

  9. EDS becoms CERN Openlab contributor

    CERN Multimedia

    2007-01-01

    "EDS announced that it has become an official contributor to CERN openlab. The purpose of the joint project beteween CERN and EDS is to carry out research and development in the field of monitoring, management and operation of grid services." (1 page)

  10. EDS becomes CERN Openlab contributor

    CERN Multimedia

    2007-01-01

    "EDS today announced that it has become an official contributor to CERN openlab. The purpose of the joint project between CERN and EDS is to carry out research and development in the field of monitoring, management and operaiton of grid services." (2/3 page)

  11. Introducing RevPASH: The Free Webtool Application

    Directory of Open Access Journals (Sweden)

    Peter Szende

    2014-10-01

    Full Text Available RevPASH (Revenue Per Available Seat Hour is an important measure that helps restaurant operators understand how efficiently each seat in a restaurant generates revenue. The RevPASH app is an easy-to-use web-tool that provides an operator with a quick way to input a few relevant numbers and calculate RevPASH.The application has the ability to compare RevPASH over different times, days, weeks, and months.

  12. TechEdSat Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall goal of the Technical Education Satellite (TechEdSat) is to employ a small spacecraft to evaluate, demonstrate, and validate two new technologies for...

  13. Suppression of atherosclerosis by synthetic REV-ERB agonist

    Energy Technology Data Exchange (ETDEWEB)

    Sitaula, Sadichha [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Billon, Cyrielle [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States); Kamenecka, Theodore M.; Solt, Laura A. [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Burris, Thomas P., E-mail: burristp@slu.edu [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States)

    2015-05-08

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.

  14. Administrative Circular No. 14 (Rev. 2)

    CERN Multimedia

    HR Department

    2007-01-01

    The HR Department wishes to draw the attention of members of the personnel to a number of amendments to Administrative Circular No. 14 (Rev. 2) entitled "Protection of members of the personnel against the financial consequences of illness, accident and disability" which came into force on 1st July 2006 (cf. Weekly Bulletin of 14 and 21 August 2006). Occupational Accident Declaration Form (HS50) https://cern.ch/service-procedures/AdminMan/Forms/HS50E.doc •\tIt must be completed within 10 working days of the date on which the accident occurred (§ 29.2.1), unless the person concerned is materially unable to meet this deadline. • The completed formula must be accompanied by a medical certificate giving details of any bodily injuries resulting from the accident (Annex 1, § 5). The medical certificate must be obtained from the doctor who has been consulted for that purpose. Benefits resulting from illnesses and accidents Medical treatment will cease to be reimbursed under ...

  15. Mitigating Higher Ed Cyber Attacks

    Science.gov (United States)

    Rogers, Gary; Ashford, Tina

    2015-01-01

    In this presentation we will discuss the many and varied cyber attacks that have recently occurred in the higher ed community. We will discuss the perpetrators, the victims, the impact and how these institutions have evolved to meet this threat. Mitigation techniques and defense strategies will be covered as will a discussion of effective security…

  16. Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function

    DEFF Research Database (Denmark)

    Bugge, Anne Skovsø; Feng, Dan; Everett, Logan J;

    2012-01-01

    of binding sites across the genome, enriched near metabolic genes. Depletion of both Rev-erbs in liver synergistically derepresses several metabolic genes as well as genes that control the positive limb of the molecular clock. Moreover, deficiency of both Rev-erbs causes marked hepatic steatosis, in contrast...

  17. Overview of Deployed EDS Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Martz, H E; Crawford, C

    2009-09-24

    The term explosive detection system (EDS) is used by the TSA to describe equipment that is certified to detect explosives in checked bags. The EDS, as certified, by the TSL must consist of device for interrogating a bag and an automated detection algorithm (ATD) for evaluating the results of the interrogation. We only consider CT as the interrogation device in this report. A schematic drawing of a CT-based EDS is shown in Figure 2. The output of the ATD is the binary decision of alarm or non-alarm. Alarms may true- or false-positives. Non-alarms may be true- or false-negatives. False positives are also denoted false alarms. The true detection means that the ATD reports an alarm when a threat is present in the scanned bag. The probability of detecting a threat given that a threat is present is denoted the probability of detection (PD). The probability of false alarm (PFA) is the case when an alarm is reported when a threat is not present in a bag. Certification in this context means passing tests for PD and PFA at the TSL. The results of the EDS include CT cross-sectional images of the bag and specifics about the alarmed objects generated by ATD. These results are presented on a display so that a person may override the decision of ATD and declare the alarm to be a non-alarm. This process is denoted clearing. Bags that are not cleared by the person are sent to a secondary inspection process. Here the bags may be opened or assessed with explosive trace detection (ETD) in order to clear the bags. Bags that are not cleared at this point are evaluated by an ordinance disposal team. The CT scanner along with ATD is denoted Level 1 screening. The process of clearing on a display is denoted Level 2 screening. Secondary inspection is denoted Level 3 screening. Vendors of the deployed EDSs supply the TSA with equipment for all three levels. Therefore, the term EDS may include the equipment provided for Levels 1, 2 and 3. A schematic diagram of an EDS and the levels of

  18. Wave power plant at Horns Rev. Screening[Denmark]; Boelgekraftanlaeg ved Horns Rev. Screening

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Hans C.; Nielsen, Kim; Steenstrup, P.R.; Friis-Madsen, E.; Wigant, L.

    2005-12-15

    The objective for the analysis has been to establish data for the sea at Horns Rev wind farm in the North Sea in order to assess the opportunity for using the site as test site for demonstration of wave energy devices exemplified by three different devices under development in Denmark. For comparison alternative sites like Hanstholm, Samsoe and Nissum Bredning are also assessed as well as the test centre EMEC at the Orkney Islands and the proposed test site Wave Hub at the north coast of Cornwall. The analysis shows that it is possible without major technical problems to connect 2-4 MW power generated by 3 different wave energy devices (AquaBuOY, Wave Star Energy and Wave Dragon) to the wind farm at Horns Rev (www.hornsrev.dk). The expenses for connection and regulation within the wind farm is about 200,000 DKK (30,00 EURO). On top of this comes the cost for individual sub sea cable connection to the wave devices, pull in of the sub sea cable through the existing J-tube in turbine T04 and the necessary regulation/control system in the individual wave devices to avoid damaging the power system in case of too high production. The analysis of the co-production of wind and wave power is dealt with in a separate report which shows that over a time period of half to one hour the time variation for wind generated electricity is 3 times as large as for wave energy generated power based on the actual measurement at Horns Rev. Further on the analysis shows that the wave generated power is more predictable than wind energy generated power as the power from the waves first is present about 2 hours after the wind is acting and last for 3 to 6 hours after the wind dies out; 6 to 12 hours with wind from west. The time is off course strongly depending of the direction of the wind i.e. the fetch. As this special report has a more general scope than the analysis as such it is reported in English (Annex Report II). The analysis shows that it is up to the individual device developer

  19. Ed Watson - 1940-2006

    CERN Document Server

    2006-01-01

    Ed Watson passed away suddenly on 1 August in Geneva, he was 66. He leaves his wife and two children. Ed Watson arrived at CERN in March 1973 to work on digital electronics and CAMAC systems under Bob Dobinson, after many years at Rolls Royce in Scotland. He joined the European Muon Collaboration in 1976, where he played a major role in the design, deployment and running of its data acquisition system (DAQ) with David Botterill, Bob Dobinson, and Vicky White. The CAMAC-ROMULUS system was by far the largest and most advanced of its time, and it became a defining standard for DAQ systems for years to come. Ed was deeply involved in the detailed planning of the control rooms and the experiment cabling, as well as sharing the responsibility for the CAMAC readout system. He had a real talent for trouble shooting and played a vital part in supporting the experiment throughout its lifetime. He offered great moral support to the younger members of the collaboration and helped them a great deal with their work. The...

  20. Ed Watson 1940-2006

    CERN Multimedia

    2006-01-01

    Ed Watson arrived at CERN in March 1973 to work on digital electronics and CAMAC systems under Bob Dobinson, after many years at Rolls Royce in Scotland. He joined the European Muon Collaboration in 1976, where he played a major role in the design, deployment and running of its data acquisition system (DAQ) with David Botterill, Bob Dobinson, and Vicky White. The CAMAC-ROMULUS system was by far the largest and most advanced of its time, and it became a defining standard for DAQ systems for years to come. Ed was deeply involved in the detailed planning of the control rooms and the experiment cabling, as well as sharing the responsibility for the CAMAC readout system. He had a real talent for trouble shooting and played a vital part in supporting the experiment throughout its lifetime. He offered great moral support to the younger members of the collaboration and helped them a great deal with their work. The EMC had a wonderful social life to which Ed was a major contributor - who can forget its barbecues?  In...

  1. DNA nuclease activity of Rev-coupled transition metal chelates.

    Science.gov (United States)

    Joyner, Jeff C; Keuper, Kevin D; Cowan, J A

    2012-06-07

    Artificial nucleases containing Rev-coupled metal chelates based on combinations of the transition metals Fe(2+), Co(2+), Ni(2+), and Cu(2+) and the chelators DOTA, DTPA, EDTA, NTA, tripeptide GGH, and tetrapeptide KGHK have been tested for DNA nuclease activity. Originally designed to target reactive transition metal chelates (M-chelates) to the HIV-1 Rev response element mRNA, attachment to the arginine-rich Rev peptide also increases DNA-binding affinity for the attached M-chelates. Apparent K(D) values ranging from 1.7 to 3.6 µM base pairs for binding of supercoiled pUC19 plasmid DNA by Ni-chelate-Rev complexes were observed, as a result of electrostatic attraction between the positively-charged Rev peptide and negatively-charged DNA. Attachment of M-chelates to the Rev peptide resulted in enhancements of DNA nuclease activity ranging from 1-fold (no enhancement) to at least 13-fold (for Cu-DTPA-Rev), for the rate of DNA nicking, with second order rate constants for conversion of DNA(supercoiled) to DNA(nicked) up to 6 × 10(6) M(-1) min(-1), and for conversion of DNA(nicked) to DNA(linear) up to 1 × 10(5) M(-1) min(-1). Freifelder-Trumbo analysis and the ratios of linearization and nicking rate constants (k(lin)/k(nick)) revealed concerted mechanisms for nicking and subsequent linearization of plasmid DNA for all of the Rev-coupled M-chelates, consistent with higher DNA residency times for the Rev-coupled M-chelates. Observed rates for Rev-coupled M-chelates were less skewed by differing DNA-binding affinities than for M-chelates lacking Rev, as a result of the narrow range of DNA-binding affinities observed, and therefore relationships between DNA nuclease activity and other catalyst properties, such as coordination unsaturation, the ability to consume ascorbic acid and generate diffusible radicals, and the identity of the metal center, are now clearly illustrated in light of the similar DNA-binding affinities of all M-chelate-Rev complexes. This work

  2. Functional MRT in psychiatry and neurology. 2. rev. and upd. ed.; Funktionelle MRT in Psychiatrie und Neurologie

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Frank [Universitaetsklinikum Aachen (Germany); Fink, Gereon R. (eds.) [Forschungszentrum Juelich GmbH (Germany); Uniklinik Koeln (Germany)

    2013-08-01

    The book on functional MRT in psychiatry and neurology covers the following topics: (I) Fundamentals: functional neuro-anatomy, fundamentals of NMR imaging, basic research on the clinical use for diagnostics and therapy; basics of morphometry; real-time fMRT, planning and execution of experimental paradigms; data analysis and statistics; reliability and quality of fMRT experiments; eye movement, neuropharmacologic functional imaging, gender dependent effects, age dependent effects, resting state fMRT; meta analyses. (II) Higher brain achievements: movement and action, perception and attention, visual system and object processing, auditory system, executive functions, somatosensoric system, memory, learning and gratification system, functional neuro-anatomy of speech, number processing and calculation, connectivity, social cognition, emotions, olfactory system, functional imaging in the pain research. (III) Disease pattern: dystonia, Parkinson syndrome, Chorea Huntington, aphasia, apraxia, neglect, amnesia, function recovery following apoplexy, schizophrenia, affective disturbances, anxiety and fear, post-traumatic disturbances, hyperactivity syndrome, personality disorder. (IV) Working tools: brain atlas, tool for integrated analyses of structure, functionality and connectivity (SPM anatomy toolbox).

  3. Turbomachinery. Hydraulic and thermal turbo-engines and turbomachines. 5. rev. ed.; Stroemungsmaschinen. Hydraulische und thermische Kraft- und Arbeitsmaschinen

    Energy Technology Data Exchange (ETDEWEB)

    Menny, K.

    2006-07-01

    Turbomachines and turbo-engines use liquid and gaseous working fluids, i.e. they cover two different states of aggregation. Mechanical engineering, thermodynamics and gas dynamics as well as construction theory must all be considered in turbomachinery design. This is what the book intends to achieve with its conceptual structure. It starts by presenting the basic scientific equations and then proceeds to the specific engineering knowledge required in turbo-engine design and construction. The fifth edition was revised in several important aspects, i.e. the transition from bar to MPa and the thermodynamic state variables of water and steam according to IAPLWS 97. For this, many examples were newly calculated. The chapter on wind power systems has been brought up to date. Contents: Common fundamentals of turbomachinery; WAter turbines; Steam turbines and steam power systems; Gas turbines; Gyropumps; Blowers and compressors; Hydrodynamic transmissions and converters; Wind rotors and propellers; Appendix. (orig.)

  4. Explosion protection in electric plants. Questions and answers. 3. rev. ed.; Explosionsschutz elektrischer Anlagen. Fragen und Antworten

    Energy Technology Data Exchange (ETDEWEB)

    Pester, J.

    2008-07-01

    Subjects: Recent legislation, especially the Explosion Protection Ordinance and the amended Ordinance on Electric Systems in Areas with High Explosion Hazard (ElexV), and interim regulations. - Responsibilities of electricity specialists and their customers. - Physical fundamentals of explosion protection and classification of areas with high explosion hazards. - Types of ignition protection and classification of electric explosion protection, with classification codes and goals. - Types and selection of explosion-protected electric systems. - Special aspects of projecting, construction, maintenance and testing of electric systems in areas with high explosion hazard. (GL)

  5. Metallography. With an introduction to ceramography. 15. rev. and enl. ed.; Metallografie. Mit einer Einfuehrung in die Keramografie

    Energy Technology Data Exchange (ETDEWEB)

    Oettel, Heinrich [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Werkstoffwissenschaft; Schumann, Hermann (eds.)

    2011-07-01

    This revised primer comprises the following chapters: Structures of inorganic materials (metals and ceramics); Metallographic techniques; Phase equilibria and state diagrams; Influence of processing and treatment on the structure of metals and alloys; Iron and iron alloys; Structures of technical nonferrous metals and their alloys; High-performance ceramics. [German] Dieses aktualisierte Grundlagenwerk ist in folgende Kapitel aufgeteilt: Strukturen anorganischer Werkstoffe (Metalle und Keramiken); Metallografische Arbeitsverfahren; Phasengleichgewichte und Zustandsdiagramme; Einfluss der Verarbeitung und Behandlung auf die Gefuegeausbildung von Metallen und Legierungen; Eisen und Eisenlegierungen; Gefuege der technischen Nichteisenmetalle und ihrer Legierungen; Hochleistungskeramik.

  6. Environmental information systems. Fundamental concepts and applications. 2. new rev. and enl. ed.; Umweltinformationssysteme. Grundlegende Konzepte und Anwendungen

    Energy Technology Data Exchange (ETDEWEB)

    Fischer-Stabel, Peter (ed.) [Hochschule Trier (Germany). Professur Geomatik und Visualisierung; Hochschule Trier (Germany). Inst. fuer Softwaresysteme in Wirtschaft, Umwelt und Verwaltung

    2013-07-01

    Environmental Information Systems (EIS) of different dimensions today represent important tools to ensure a fast and qualified action in the face of the ever-growing needs of the environment. This publication is an interdisciplinary textbook which contents convey the conception and development of environmental information systems. Accessing the innovations of the last five years in the development of EIS in their 2nd Edition: in addition to the various disciplines which traditionally have to contribute in the development of environmental information systems, new topics had been modified in the present edition, to take into account of the extended interests of students in the framework of environmental information technology education. [German] Umweltinformationssysteme (UIS) der verschiedensten Dimensionen stellen heute wichtige Hilfsmittel dar, um angesichts der staendig wachsenden Anforderungen im Umweltbereich ein schnelles und qualifiziertes Handeln sicherzustellen. Diese Publikation ist ein interdisziplinaer angelegtes Lehrbuch, dessen Inhalte die Konzeption und Entwicklung von Umweltinformationssystemen vermitteln. Sie greift in ihrer 2. Auflage die Innovationen der letzten fuenf Jahre in der Entwicklung von UIS auf: Neben den verschiedenen Disziplinen, welche traditionell bei der Entwicklung von Umweltinformationssystemen Beitraege leisten muessen, wurden in der vorliegenden Auflage auch neue Themenfelder bearbeitet, um den erweiterten Interessen der Studierenden im Rahmen einer umweltbezogenen informationstechnischen Ausbildung Rechnung zu tragen.

  7. Table manual mechatronics. Tables, formulas, application of standards. 3. rev. and enl. ed.; Tabellenbuch Mechatronik. Tabellen, Formeln, Normenanwendung

    Energy Technology Data Exchange (ETDEWEB)

    Haeberle, G.; Haeberle, H.; Kilgus, R.; Krall, R.; Luecke, T.; Paetzold, H.; Rieger, K.; Roehrer, W.; Schiemann, B.; Schmitt, S.; Schultheiss, M.; Stephan, A.; Urian, T.

    2004-07-01

    The book covers all data and formulas from the main volume. The main topics are: fundamentals on data processing; technical communication; test engineering; quality management; materials engineering; mechanical systems; production of mechanical systems; fundamentals on electrical engineering; electric machines and devices; control systems; remote systems in automation engineering; mechatronic systems and their installation, commissioning and maintenance. (GL)

  8. Nuclear medicine. Basic knowledge and clinical applications. 7. rev. and enl. ed.; Nuklearmedizin. Basiswissen und klinische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Schicha, Harald [Universitaetsklinikum Koeln (Germany). Medizinisches Versorgungszentrum II; Schober, Otmar [Universitaetsklinikum Muenster (Germany). Klinik fuer Nuklearmedizin

    2013-11-01

    The book on basic knowledge and clinical applications of nuclear medicine covers the following issues: The first general part: principles of nuclear medicine; physical fundamentals; radiopharmaceutical chemistry; measuring techniques: gamma detectors, gamma spectrometry, gamma camera, SPECT, PET, PET/CT, PET/NMR, image processing and communication; nuclear medical examinations: metabolic and pharmacological kinetics, scintigraphic methods, criteria for the use; quality assurance; dosimetry and radiation protection, radiation risks and patients exposure, benefit-risk considerations. The second part covers endocrine organs, carcinomas, skeleton and bone joints, inflammations, lymph system, cardiovascular system, lungs, central nervous system, kidneys and urinary system, gastrointestinal tract, other scintigraphic examinations.

  9. Communal sewage systems. Dimensioning, extension, optimization, cost. 2. tot. new rev. ed.; Kommunale Klaeranlagen. Bemessung, Erweiterung, Optimierung und Kosten

    Energy Technology Data Exchange (ETDEWEB)

    Guenthert, F.W.; Reicherter, E.; Gallent, W. [Universitaet der Bundeswehr Muenchen, Neubiberg (Germany). Inst. fuer Wasserwesen; Baumann, P. [Wave GmbH, Stuttgart (Germany); Guender, B. [Berghof Filtrations- und Anlagentechnik GmbH und Co. KG, Eningen (Germany); Kapp, H. [Fachhochschule Biberach - Hochschule fuer Bauwesen und Wirtschaft, Biberach an der Riss (Germany); Mueller, J. [Technische Universitaet, Braunschweig (Germany). Institut fuer Siedlungswasserwirtschaft; Riedl, J. [Wasserwirtschaftsamt Weilheim (Germany); Steinle, E. [Dr. Steinle Ingenieurgesellschaft fuer Abwassertechnik, Weyam (Germany); Strohmeier, A. [Fachhochschule Aachen (Germany)

    2001-07-01

    The book presents practical solutions to current problems encountered in the projecting and construction of sewage systems: Fundamentals of biological sewage treatment, biological processes (activation, immersion disks, submerged fixed bed), further treatment of effluents; Dimensioning of activation systems, alternative processes, extension and optimization of existing sewage treatment systems, simulations and cost of process selection; Further treatment of effluents with phosphorus elimination and filtration systems; Sewage sludge treatment and its effects on waste water treatment and cost. [German] Das Buch bietet praxisnahe Problemloesungen fuer die heute anstehenden Fragestellungen bei Planung und Bau von Abwasserbehandlungsanlagen. In der ersten Auflage Bemessung von kommunalen Klaeranlagen wird sehr ausfuehrlich auf die Grundlagen der biologischen Abwasserreinigung, die verschiedenen Verfahren (Belebungsanlagen, Tropfkoerperanlagen, Anlagen mit getauchtem Festbett) sowie die weitergehende Abwasserreinigung eingegangen. Aufbauend auf diesen Grundlagen enthaelt die vorliegende zweite Auflage die inzwischen weiter entwickelten Bemessungsansaetze fuer das Belebungsverfahren (Belebung und Nachklaerung). Zudem werden Verfahrenspielraeume und Verfahrensalternativen (SBR-Anlagen) fuer den Bau und die Erweiterung und Optimierung von bestehenden Abwasserbehandlungsanlagen aufgezeigt. Grundlagen der Simulation und Ermittlung der anfallenden Kosten zur Bewertung von Verfahrensvarianten sollen dem Anwender helfen, die betrieblich und wirtschaftlich beste Loesung zu finden. Die weitergehende Abwasserbehandlung mit Phosphoreliminaton und Filtrationsanlagen ist in zwei Beitraegen ausfuehrlich dargestellt. Abschliessend wird auf die Klaerschlammbehandlung eingegangen, insbesondere auf ihre Auswirkungen auf die Abwasserbehandlung und deren Kosten. (orig.)

  10. Renewable resources in industry. Industrial use of agricultural and wood raw materials in Germany. 3. compl. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Peters, Dietmar

    2010-11-17

    The ''Action Plan for the Industrial Use of Renewable Resources'' that was adopted by the German Federal Government in 2009 is an important impulse for promoting the industrial use of renewable resources parallel to their use for energy generation. The Action Plan sets forth a broad vision, not only for a significant and sustainable increase in the proportion of biomass used in industry but also for an improvement in the efficiency of biomass use in ensuring Germany's raw material supplies while taking into account the objectives and requirements of sustainability strategies. It also aims to secure and advance Germany's role as an international leader in the industrial use of renewable resources. This brochure provides an overview of the possible industrial uses of renewable resources in Germany and illustrates the important role that agricultural raw materials and wood already play in today's industry. (orig.)

  11. The refrigeration technicians. Handbook for the practice. 11. rev. and enl. ed.; Der Kaeltemonteur. Handbuch fuer die Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Seidel, Rolf; Noack, Hugo

    2008-07-01

    The technical book under consideration is a standard work of the refrigerant plant technology established since years. Therein, refrigeration technicians and refrigeration plants suppliers find all important approaches when assembling, maintenance as well as repair and maintenance of refrigerant plants, and answers on complex questions from the occupational everyday life. Apart from physical fundamentals, the components of refrigerant plants are described. Detailed execution of measurements and service work also are described. Concisely formulated mnemonics emphasize the essential points and supply a fast overview.

  12. Computed tomography of the head and spinal cord. 2. rev. and enl. ed.; Computertomographie von Kopf und Wirbelsaeule

    Energy Technology Data Exchange (ETDEWEB)

    Hosten, N. [Greifswald Univ. (Germany). Inst. fuer Diagnostische Radiologie und Neuroradiologie; Liebig, T. [Klinikum rechts der Isar, Muenchen (Germany). Abt. Neuroradiologie

    2007-07-01

    This is an everyday reference manual for routine diagnosis and also for critical situations; it is a reliable vademecum for all radiologists, neurologists and neurosurgeons. It contains all information that is required for CT diagnosis of the skull and spinal cord. Detailed information on normal anatomy and standard reference values enable the practician to differentiate between normal and pathological findings. There is a clear and didactically useful structure with sections on pathogenesis, clinical findings and CT morphology for each clinical picture. (orig.)

  13. Guide biogas. From production to utilization. 5. compl. rev. ed.; Leitfaden Biogas. Von der Gewinnung zur Nutzung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    The book under consideration is a guide for biogas and consists of the following contributions: (a) Targets of the guide (M. Kaltschmitt); (b) Fundamentals of anaerobic fermentation (J. Friehe); (c) Systems engineering for supplying biogas (J. Postel); (d) Description of selected substrates (J. Friehe); (e) Operation of biogas plants (J. Liebetrau); (f) Gas processing and possibilities of utilization (M. Wetthaeuser); (g) Legal and administrative framework conditions (H. von Bredow); (g) Economy (S. Hartmann); (h) Company organisation (G. Reinhold); (i) Quality and utilization of fermentation residues (H. Doehler); (j) Implementation of a project (E. Fischer); (k) Position and significance of biogas as a renewable energy resource in Germany (M. Kaltschmitt); (l) Project examples (J. Friehe).

  14. Solar systems. Manual of thermal solar energy use. 6. rev. and enl. ed.; Solaranlagen. Handbuch der thermischen Solarenergienutzung

    Energy Technology Data Exchange (ETDEWEB)

    Ladener, H.; Spaete, F.

    1999-07-01

    Fundamentals, calculation and construction of solar heating systems for swimming pools, freshwater and rooms. Starting from the basic elements, i.e. collector, storage and heat transfer, the manual shows how solar systems are projected, dimensioned and construction. Established concepts for small and medium-sized plants are described as well as the new technologies for large space and water heating systems. Performance data are presented as well as information on cost and economic efficiency in order to present an outline of the state of the art and to gove planners and practical experts a concrete decision aid. Examples of existing systems are presented. [German] Grundlagen, Planung und Bau solarer Waermeerzeugungsanlagen zur Schwimmbadheizung, Trinkwassererwaermung und Raumheizung. Ausgehend von den Elementen Kollektor, Speicher und Waermetransport wird in diesem Handbuch gezeigt, wie Solaranlagen geplant, dimensioniert und gebaut werden. Bewaehrte Anlagenkonzepte fuer kleine und mittlere Anlagen werden ebenso beschrieben wie die in neuester Zeit entwickelten Techniken fuer grosse Anlagen zur Warmwasserbereitung und Raumheizung. Erfahrungen ueber die Leistung von Solaranlagen sowie Angaben ueber Kosten und Wirtschaftlichkeit zeigen den Stand der Technik und geben Planern, Handwerkern und Praktikern konkrete Entscheidungshilfen. Mit Beispielen ausgefuehrter Anlagen. (orig.)

  15. Hydrogen in motor car engineering. Production, storage, uses. 2. rev. and enl. ed.; Wasserstoff in der Fahrzeugtechnik. Erzeugung, Speicherung, Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Eichlseder, Helmut; Klell, Manfred

    2010-07-01

    The book presents a general outline of the various aspects of characteristics, generation, storage and applications of hydrogen. The focus is on the thermodynamic aspects of hydrogen storage and on its uses in automotive engineering and power engineering. The 2nd edition also contains a new chapter on fuel cells for power generation for electric motors and a chapter on hydrogen production by pyrolysis of glycerine. New information is presented on current applications, internal combustion engines fuelled with mixtures of hydrogen and methane, materials, efficiency aspects, and CO2 emissions. [German] Das Buch bietet einen allgemeinen Ueberblick ueber die verschiedenen Aspekte von Eigenschaften, Erzeugung, Speicherung und Anwendung von Wasserstoff. Schwerpunkte liegen auf der Thermodynamik der Speicherung von Wasserstoff sowie auf der Anwendung in der Fahrzeugtechnik und in der Energietechnik. Als eigener Abschnitt wurde in dieser 2. Auflage die Brennstoffzelle zur Stromerzeugung fuer Elektroantriebe ergaenzt. Ein Verfahren zur Wasserstoffproduktion durch Pyrolyse aus Glycerin wurde neu aufgenommen. Ergaenzt wurden Abschnitte ueber aktuelle Anwendungen, ueber Verbrennungsmotoren fuer Gemische aus Wasserstoff und Methan, ueber Werkstoffe sowie Fragen von Wirkungsgrad und CO{sub 2}-Emissionen.

  16. The Stirling engine. Simply explained, easily constructed. 9. rev. and enl. ed.; Der Stirlingmotor. Einfach erklaert und leicht gebaut

    Energy Technology Data Exchange (ETDEWEB)

    Viebach, Dieter

    2010-07-01

    Subsequently to a easily comprehensively description of the function and characteristics of Stirling engines, the author of the book under consideration describes the construction of a model Stirling engine on the basis of clear construction drawings. A delicacy for experienced modelers: The 'amazing model', a miniature Stirling engine consisting of beverage cans, has been running with the warmth of the human hand. Even in this technically demanding model, the construction will be described accurately by detailed construction drawings.

  17. Stirling engine technology. Fundamentals, concepts, developments, applications. 2. tot. new rev. ed.; Stirling-Maschinen-Technik. Grundlagen, Konzepte, Entwicklungen, Anwendungen

    Energy Technology Data Exchange (ETDEWEB)

    Steimle, F.; Lamprichs, J.; Beck, P.

    2007-07-01

    The book presents the technology of Stirling engines, their history, types, new trends and current and future applications. Commercially successful Stirling engines are presented. The second edition of this book focuses on decentral combined heat and power generation, utilisation of biomass and solar energy, heat pumps and refrigerators. Thermodynamic fundamentals of various types of Stirling engines are described, as well as requirements on engine components, and the ecological and economic advantages of the Stirling technology. A revised list of international suppliers, research institutions and individuals working in this field is contained in the appendix. (orig.)

  18. Combined scintigraphic and radiographic diagnosis of bone and joint diseases. Including gamma correction interpretation. 4. rev. and enl. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong-Whee [Sung Ae General Hospital, Seoul (Korea, Republic of). Dept. of Nuclear Medicine and Radiology

    2013-07-01

    In this fourth edition of Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, the text has been thoroughly amended, updated, and partially rearranged to reflect the latest advances. In addition to discussing the role of pinhole imaging in the range of disorders previously covered, the new edition pays detailed attention to the novel diagnostic use of gamma correction pinhole bone scan in a broad spectrum of skeletal disorders, including physical, traumatic, and sports injuries, infectious and non-infectious bone diseases, benign and malignant bone tumors, and soft tissue diseases. A large number of state of the art pinhole scans and corroborative CT, MRI, and/or ultrasound images are presented side by side. The book has been enlarged to encompass various new topics, including occult fractures; cervical sprain and whiplash trauma; bone marrow edema; microfractures of trabeculae; evident, gaping, and stress fractures; and differential diagnosis. This new edition will be essential reading for practitioners and researchers in not only nuclear medicine but also radiology, orthopedic surgery, and pathology.

  19. Diagnostic radiology of the osteo-articular system. 3. rev. and enl. ed.; Radiologische Diagnostik der Knochen und Gelenke

    Energy Technology Data Exchange (ETDEWEB)

    Bohndorf, Klaus [Medizinische Univ. Wien (Austria). Exzellenzzentrum Hochfeld-Magnetresonanz; Woertler, Klaus (ed.) [Technische Univ. Muenchen Klinikum rechts der Isar (Germany). Inst. fuer Radiologie; Imhof, Herwig

    2014-02-01

    The book on diagnostic radiology of the osteo-articular system includes the following chapters: (1) Acute trauma and chronic overstress: essentials; (2) Acute trauma and chronic overstress (according regions); (3) Infections of bones, bone joints and soft tissue; (4) Tumors and tumor-like lesions of bones, bone joints and soft tissue; (5) Bone marrow; (6) Skeleton necrosis; (7) Osteochondrosis; (8) Metabolic, hormone related and toxically induced osteopathy; (9) Constitutional skeleton and bone joint development disturbances; (1) Rheumatic diseases; (11) Different skeletal, bone joint and soft tissue diseases; (12) Interventional actions at the skeleton, soft tissue and bone joints; (13) Radiological imaging of skeleton and bone joints.

  20. Examinations for radiology. 1450 examination questions, with comments. 3. rev. and enl. ed.; Facharztpruefung Radiologie. 1450 kommentierte Pruefungsfragen

    Energy Technology Data Exchange (ETDEWEB)

    Albes, Guido [Klinikum Stuttgart (Germany). Neurozentrum

    2013-07-01

    The book on examinations for radiology contains 1450 examination questions, with comments. The chapter on technical fundamentals and radiation protection covers the topics X-ray technologies, ultrasound and magnetic resonance tomography. The chapter on specific diagnostic radiology covers the topics brain, spinal cord, head and neck, thorax, abdomen and pelvis organs and the muscoskeletal system.

  1. Clinical neuroanatomy - cranial MRI and CT. 4. rev. and enl. ed.; Klinische Neuroanatomie - kranielle MRT und CT

    Energy Technology Data Exchange (ETDEWEB)

    Lanfermann, Heinrich; Raab, Peter [Medizinische Hochschule Hannover (MHH) (Germany). Inst. fuer Diagnostische und Interventionelle Neuroradiologie; Kretschmann, Hans-Joachim; Weinrich, Wolfgang

    2015-07-01

    The book on clinical neuroanatomy - cranial MRI and CT covers the following issues: layered imaging diagnostics and reference structures; frontal layer, sagittal layers, transverse layers, brainstem, skull topography and the intracranial spaces and structures, facial skull topography, head-neck topography; neurofunctional systems, neurotransmitter and neuromodulators, surveillance material and techniques.

  2. Electric power supply in the 21st century. Proceedings. 2. rev. ed.; Stromversorgung des 21. Jahrhunderts. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    The proceedings include contributions to the following topics: The role of energy in the future society; efficiency enhancement by electric power; electromobility and power industry - future prospects of energy suppliers; better place - marketing model for electromobility; electric heating systems - techniques, efficiency and potentials; energy saving by smart metering; development of the electricity demand in Germany until 2050; energy supply concepts in the frame of IEKP; future of fossil duels in electricity generation; future of nuclear power in Europe; power-heat cogeneration for local heat and long-distance heat; micro CHP and virtual power plants; renewable energy - new challenges for transport and storage; possible development of the power generation system until 2050; electricity and electricity industry - how to improve the image? energy and climate policy consulting - experiences and expectations.

  3. Administrative Circular N° 26 (Rev.  5) - November 2004

    CERN Multimedia

    Human Resources Department

    2004-01-01

    Procedure governing the career evolution of staff members The introduction of an electronic individual appraisal report form via EDH for the MAPS exercise entails some modifications to Administrative Circular N° 26 (Rev. 4). The revised version (Rev. 5) is available in departmental secretariats as well as on the Web at the following address: http://cern.ch/hr-web/internal/admin_services/admincirc/listadmincirc.asp Human Resources Department Tel. 74128

  4. AdvancED Flex 4

    CERN Document Server

    Tiwari, Shashank; Schulze, Charlie

    2010-01-01

    AdvancED Flex 4 makes advanced Flex 4 concepts and techniques easy. Ajax, RIA, Web 2.0, mashups, mobile applications, the most sophisticated web tools, and the coolest interactive web applications are all covered with practical, visually oriented recipes. * Completely updated for the new tools in Flex 4* Demonstrates how to use Flex 4 to create robust and scalable enterprise-grade Rich Internet Applications.* Teaches you to build high-performance web applications with interactivity that really engages your users.* What you'll learn Practiced beginners and intermediate users of Flex, especially

  5. Pärnu REV sai kuuekümneseks / Andres Mets

    Index Scriptorium Estoniae

    Mets, Andres, 1943-

    2004-01-01

    Ehitusfirma Pärnu REV tähistab ainsa toimiva ja sisu muutnud remondi- ja ehitusvalitsusena kuuekümneaastast juubelit. Kommenteerivad REV-i nõukogu esimees Raivo Pulk ja REV-i juhataja Uno Kõressaar

  6. Pärnu REV sai kuuekümneseks / Andres Mets

    Index Scriptorium Estoniae

    Mets, Andres, 1943-

    2004-01-01

    Ehitusfirma Pärnu REV tähistab ainsa toimiva ja sisu muutnud remondi- ja ehitusvalitsusena kuuekümneaastast juubelit. Kommenteerivad REV-i nõukogu esimees Raivo Pulk ja REV-i juhataja Uno Kõressaar

  7. Real time analysis under EDS

    Energy Technology Data Exchange (ETDEWEB)

    Schneberk, D.

    1985-07-01

    This paper describes the analysis component of the Enrichment Diagnostic System (EDS) developed for the Atomic Vapor Laser Isotope Separation Program (AVLIS) at Lawrence Livermore National Laboratory (LLNL). Four different types of analysis are performed on data acquired through EDS: (1) absorption spectroscopy on laser-generated spectral lines, (2) mass spectrometer analysis, (3) general purpose waveform analysis, and (4) separation performance calculations. The information produced from this data includes: measures of particle density and velocity, partial pressures of residual gases, and overall measures of isotope enrichment. The analysis component supports a variety of real-time modeling tasks, a means for broadcasting data to other nodes, and a great degree of flexibility for tailoring computations to the exact needs of the process. A particular data base structure and program flow is common to all types of analysis. Key elements of the analysis component are: (1) a fast access data base which can configure all types of analysis, (2) a selected set of analysis routines, (3) a general purpose data manipulation and graphics package for the results of real time analysis. Each of these components are described with an emphasis upon how each contributes to overall system capability. 3 figs.

  8. HIV-1 tat and rev upregulates osteoclast bone resorption

    Directory of Open Access Journals (Sweden)

    Nicholas Chew

    2014-11-01

    Full Text Available Introduction: Disruption in bone homeostasis with increased osteoclastic resorption may lead to osteoporosis. HIV tat has been found to increase differentiation of precursor cells into osteoclast (OC (1. Presence of soluble HIV proteins in virally suppressed HIV patients on ART may drive a bone resorption phenotype. We investigated the role of soluble HIV proteins (tat, gp120 Mn and Bal, rev and p55-gag on osteoclastogenesis and OC resorptive capacity. Methods: Mouse monocyte RAW 264.7 cells were cultured in vitro and induced to differentiate into OCs with 50 ng/mL RANKL and 25 ng/mL mCSF. Medium was supplemented with 100 ng/mL of recombinant HIV tat, gp120 (Mn and Bal, rev, nef and p55-gag, respectively, with zolendronate as negative control. Differentiated OCs were stained for TRAP and counted. OC resorption function was examined by culturing differentiated OCs (in the presence of respective HIV proteins on dentin-coated plates and examining the following (i sealing zone formation, (ii volume of resorption pits and (iii area of resorption pits per field using confocal microscopy. Expression of OC specific genes including NFATc1 and cathepsin K was investigated by qPCR. Reactive oxygen species (ROS production is essential in RANKL-induced OC differentiation (2,3; effect of these proteins on ROS production was assessed using the fluorescent H2DCFH-DA. Mean fluorescence intensity was then measured by flow cytometry. TNFα production by OC precursors when incubated with tat and rev was measured by ELISA. Results: Tat and rev treatment was associated with increased OC formation by 70 and 26%, respectively (p<0.01, relative to control, while zolendronate significantly inhibited OC formation by 75%. Gp120 Mn and Bal, nef and p55-gag treatment had no effect on OC differentiation. Interestingly, neither tat nor rev treatment caused significant increases in sealing zone formation but increased dentin resorption pit area by 28 and 19%, respectively, and

  9. Administrative Circular No. 26 (Rev. 9) – Recognition of Merit

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 26 (Rev. 9) entitled "Recognition of Merit”, approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 September 2011 is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp The circular was above all revised in order to integrate the new CERN Competency Model into the annual procedure of performance appraisal. It cancels and replaces Administrative Circular No. 26 (Rev. 8) entitled "Recognition of merit” of September 2008. Department Head Office HR Department

  10. Administrative Circular No. 26 (Rev. 7) – May 2007

    CERN Multimedia

    HR Department

    2007-01-01

    Recognition of Merit of Staff Members Administrative Circular No. 26 (Rev. 7) is now available on the intranet site of the Human Resources Department. This circular cancels and replaces Administrative Circular No. 26 (Rev. 6) - Procedures governing the career development of staff members. Copies will shortly be available in Departmental secretariats. If you require any additional information on the new staff-member merit assessment and recognition system, you may consult the FAQ, which has been available on the Human Resources Department intranet site since February 2007. Human Resources Department Tel. 78003

  11. Due etimologie venete ed istriane

    Directory of Open Access Journals (Sweden)

    Alberto Zamboni

    1991-12-01

    Full Text Available Un isolato dialetto del Medio Agordino (La Valle, BL attesta per 'ginepro' (Juniperus eommunis L., d'altronde compattamente designato come dzené(iver, deneore il termine bozičo che richiama il busicio dato già per l'area bellunese dal Soravia (1877, 108. II Pellegrini (1964, 28 enota 51 ne riscontra il perfetto corrispondente del Veneto orientale buzíčo documentato al p. 356 (S. Stino di Livenza dali' AIS 599 e l'accosta senz'altro al padovano (in realtà piuttosto veneziano di terraferma brusiehio (eh = (č! segnalato dal Patriarchi (1821, ma I'ed. 1775 e che si giustificherebbe con l'intrusione di 'bruciare' dal noto usodi bruciare le bacche della pianta per suffumigi, cfr. il ted. regionale Feuerbaum (su cui Marzell 2/1972, 1091 e anche il tipo brusìn dell'alta Val di Sole (Pedrotti-Bertoldi 1931, 206s.. Si osservi che anche il grande repertorio poliglotta del Nemnich (3/1794, 267 dà esplicitamente brusichio per Venezia. Sul tipo e sull'etimo il Pellegrini ritorna più avanti (1982, 185 riassumendo la bibliografia precedente e aggiungendo documentazioni dall' ASLEF: bo/ič al p. 172 (Chions, PN e ancora nel friulano occidentale (in pratica sempre nella zona di confine col veneto sbrodicio, sbradicio a Budoia (AppiSanson 1970, 28;

  12. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-01-01

    The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised.

  13. Wind Farm Wake: The Horns Rev Photo Case

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Rasmussen, Leif; Peña, Alfredo

    2013-01-01

    The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea...

  14. Revised Safety Instruction NO. 4 (IS4 REV.)

    CERN Multimedia

    2006-01-01

    Please note that the revised safety instruction no. 4 (IS4 REV.), entitled 'Safety Inspections' is available on the web at the following url: https://edms.cern.ch/file/335741/LAST_RELEASED/E_IS4.pdf Paper copies can be obtained from the SC unit secretariat. SC Secretariat e-mail: sc.secretariat@cern.ch

  15. Revised Safety Instruction NO. 4 (IS4 REV.)

    CERN Multimedia

    SC Secretariat

    2006-01-01

    Please note that the revised safety instruction No. 4 (IS4 REV.), entitled 'Safety Inspections' is available on the web at the following url: https://edms.cern.ch/file/335741/LAST_RELEASED/E_IS4.pdf Paper copies can be obtained from the SC unit secretariat. SC Secretariat e-mail: sc.secretariat@cern.ch

  16. Revised Safety Instruction NO. 4 (IS4 REV.)

    CERN Multimedia

    2006-01-01

    Please note that the revised safety instruction no. 4 (IS4 REV.), entitled 'Safety Inspections' is available on the web at the following url: https://edms.cern.ch/file/335741/LAST_RELEASED/E_IS4.pdf Paper copies can be obtained from the SC unit secretariat. SC Secretariat sc.secretariat@cern.ch

  17. Wind Farm Wake: The 2016 Horns Rev Photo Case

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Nygaard, Nicolai Gayle; Volker, Patrick

    2017-01-01

    Offshore wind farm wakes were observed and photographed in foggy conditions at Horns Rev 2 on 25 January 2016 at 12:45 UTC. These new images show highly contrasting conditions regarding the wind speed, turbulence intensity, atmospheric stability, weather conditions and wind farm wake development...

  18. GeneEd -- A Genetics Educational Resource

    Science.gov (United States)

    ... Javascript on. Feature: Genetics 101 GeneEd — A Genetics Educational Resource Past Issues / Summer 2013 Table of Contents Science ... The Hereditary Material of Life / GeneEd — A Genetics Educational Resource / Using The Genetics Home Reference Website / Understanding the ...

  19. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-03-14

    Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein) as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  20. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

    Directory of Open Access Journals (Sweden)

    Sheehy Noreen

    2011-03-01

    Full Text Available Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  1. Administrative Circular No. 26 (Rev.10) - Recognition of merit

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 26 (Rev. 10) entitled “Recognition of Merit”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to staff members. It cancels and replaces Administrative Circular No. 26 (Rev. 9) entitled “Recognition of Merit” of December 2011. The circular was revised in order to take into account the work performed in the framework of an elective mandate during the exercise of merit recognition of staff members. In addition, the circular was revised to provide that, in the case of staff members on special leave for professional reasons for a period equal to or longer than half a year, it will no longer be possible to grant an exceptional advancement. Department Head Office HR Department

  2. Administrative Circular No. 23 (Rev. 4) - Special working hours

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 23 (Rev. 4) entitled "Special working hours", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208539.   This revised circular cancels and replaces Administrative Circular No. 23 (Rev. 3) also entitled "Special working hours" of January 2013. This document contains modifications to reflect the new career structure and ensuring the provision consistent with practice that compensation or remuneration of special working hours performed remotely is possible only in case of emergency.   This circular will enter into force on 1st September 2016.

  3. Operational circular No. 1 (Rev. 1) – Operational circulars

    CERN Multimedia

    HR Department

    2011-01-01

    Operational Circular No. 1 (Rev. 1) is applicable to members of the personnel and other persons concerned. Operational Circular No. 1 (Rev. 1) entitled "Operational circulars", approved following discussion at the Standing Concertation Committee meeting on 4 May 2011, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 1 entitled "Operational Circulars” of December 1996. This new version clarifies, in particular, that operational circulars do not necessarily arise from the Staff Rules and Regulations, and the functional titles have been updated to bring them into line with the current CERN organigram. Department Head Office  

  4. Safety Instruction nº 23 (IS 23 Rev. 3)

    CERN Multimedia

    SC Secretariat

    2005-01-01

    Please note that the revised version of Safety Instruction no 23 (IS 23 rev. 3) entitled "Criteria and standard test methods for the selection of electric cables and wires with respect to fire safety and radiation resistance" is available on the web at the following url: https://edms.cern.ch/document/335745/LAST_RELEASED/ Paper copies can also be obtained from the SC Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  5. International Field Reversible Thermal Connector (RevCon) Challenge

    Science.gov (United States)

    2016-07-01

    AFRL-RY-WP-TR-2016-0108 INTERNATIONAL FIELD REVERSIBLE THERMAL CONNECTOR (RevCon) CHALLENGE Chung-Lung Chen University of...or corporation; or convey any rights or permission to manufacture, use, or sell any patented invention that may relate to them. This report is...DD-MM-YY) 2. REPORT TYPE 3. DATES COVERED (From - To) July 2016 Final 07 November 2013 – 15 March 2016 4. TITLE AND SUBTITLE INTERNATIONAL

  6. REV-ERB and ROR: therapeutic targets for treating myopathies

    Science.gov (United States)

    Welch, Ryan D.; Flaveny, Colin A.

    2017-08-01

    Muscle is primarily known for its mechanical roles in locomotion, maintenance of posture, and regulation of cardiac and respiratory function. There are numerous medical conditions that adversely affect muscle, myopathies that disrupt muscle development, regeneration and protein turnover to detrimental effect. Skeletal muscle is also a vital secretory organ that regulates thermogenesis, inflammatory signaling and directs context specific global metabolic changes in energy substrate preference on a daily basis. Myopathies differ in the causative factors that drive them but share common features including severe reduction in quality of life and significantly increased mortality all due irrefutably to the loss of muscle mass. Thus far clinically viable approaches for preserving muscle proteins and stimulating new muscle growth without unwanted side effects or limited efficacy has been elusive. Over the last few decades, evidence has emerged through in vitro and in vivo studies that suggest the nuclear receptors REV-ERB and ROR might modulate pathways involved in myogenesis and mitochondrial biogenesis. Hinting that REV-ERB and ROR might be targeted to treat myopathies. However there is still a need for substantial investigation into the roles of these nuclear receptors in in vivo rodent models of degenerative muscle diseases and acute injury. Although exciting, REV-ERB and ROR have somewhat confounding roles in muscle physiology and therefore more studies utilizing in vivo models of skeletal muscle myopathies are needed. In this review we highlight the molecular forces driving some of the major degenerative muscular diseases and showcase two promising molecular targets that may have the potential to treat myopathies: ROR and REV-ERB.

  7. RevPAR、GOP率、GOPPAR的联动增长

    Institute of Scientific and Technical Information of China (English)

    陈雪羽

    2007-01-01

    RevPAR,指平均每间可售客房产生的收入,其计算方式是酒店客房的全年营收总额除以全年可供出售的客房总间数,或者用更简化的方式,就是用平均房价乘以平均出租率。

  8. Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

    Science.gov (United States)

    Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M

    2017-02-01

    HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding.

  9. User Instructions for the Systems Assessment Capability, Rev. 1, Computer Codes Volume 3: Utility Codes

    Energy Technology Data Exchange (ETDEWEB)

    Eslinger, Paul W.; Aaberg, Rosanne L.; Lopresti, Charles A.; Miley, Terri B.; Nichols, William E.; Strenge, Dennis L.

    2004-09-14

    This document contains detailed user instructions for a suite of utility codes developed for Rev. 1 of the Systems Assessment Capability. The suite of computer codes for Rev. 1 of Systems Assessment Capability performs many functions.

  10. Administrative Circulars No. 12 A (Rev. 2) - "Education fees” and No. 12 B (Rev. 2) - “Education fees and language courses”

    CERN Multimedia

    2013-01-01

    Administrative Circulars No. 12 A (Rev. 2) entitled “Education fees” and No. 12 B (Rev. 2) entitled “Education fees and language courses”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, are available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 12 A (Rev. 2) is applicable to Staff Members (except former “Local Staff Members”) recruited before 1st January 2007. Administrative Circular No. 12 B (Rev. 2) is applicable to Staff Members recruited on or after 1st January 2007, to Fellows, to Scientific Associates, to Guest Professors and to former “Local Staff” recruited before 1st January 2007. They cancel and replace Administrative Circulars No. 12 A (Rev. 1/Corr.) entitled "Education fees” and No. 12 B (Rev. 1/Corr.) entitled “Edu...

  11. Sampling and estimation techniques for the implementation of new classification systems: the change-over from NACE Rev. 1.1 to NACE Rev. 2 in business surveys

    Directory of Open Access Journals (Sweden)

    Jan van den Brakel

    2010-09-01

    Full Text Available This paper describes some of the methodological problems encountered with the change-over from the NACE Rev. 1.1 to the NACE Rev. 2 in business statistics. Different sampling and estimation strategies are proposed to produce reliable figures for the domains under both classifications simultaneously. Furthermore several methods are described that can be used to reconstruct time series for the domains under the NACE Rev. 2.

  12. "What do people do if they don't have insurance?": ED to ED Referrals.

    Science.gov (United States)

    Medford-Davis, Laura N; Prasad, Siddharth; Rhodes, Karin V

    2017-08-28

    Up to 20% of patients seen in public emergency departments (EDs) have already been seen for the same complaint at another ED, but little is known about the origin or impact of these duplicate ED visits. The goals of this investigation were to explore (1) whether patients making a repeat ED visit are self-referred or indirectly referred from the other ED; and (2) gather the perspective of affected patients on the health, social, and financial consequences of these duplicate ED visits. This mixed-methods study conducted over a 10-week period during 2016 in a large public hospital ED in Texas prospectively surveyed patients seen in another ED for the same chief complaint. Selected patients presenting with fractures were then enrolled for semi-structured qualitative interviews, which were audiotaped, transcribed, and independently coded by two team members until thematic saturation was reached. 143 patients were identified as being recently seen at another local ED for the same chief complaint prior to presenting to the public hospital; 94% were uninsured and 61% presented with fractures. 27% required admission at the public ED and 95% of those discharged required further outpatient follow-up. 51 patients completed a survey and qualitative interviews were conducted with 23 fracture patients. 53% of patients reported that staff at the first hospital told them to go the public hospital ED, and 23% reported referral from a follow-up physician associated with the first hospital. 73% reported receiving the same tests at both EDs. Interview themes identified multiple healthcare visits for the same injury, concern about complications, disrespectful treatment at the first ED, delayed care, problems accessing needed follow-up care without insurance, loss of work, and financial strain. The majority of patients presenting to a public hospital ED after treatment for the same complaint in another local ED were indirectly referred to the public ED without transferring paperwork or

  13. On the quantitativeness of EDS STEM

    Energy Technology Data Exchange (ETDEWEB)

    Lugg, N.R. [Institute of Engineering Innovation, The University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo 113-8656 (Japan); Kothleitner, G. [Institute for Electron Microscopy and Nanoanalysis, Graz University of Technology, Steyrergasse 17, 8010 Graz (Austria); Centre for Electron Microscopy, Steyrergasse 17, 8010 Graz (Austria); Shibata, N.; Ikuhara, Y. [Institute of Engineering Innovation, The University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo 113-8656 (Japan)

    2015-04-15

    Chemical mapping using energy dispersive X-ray spectroscopy (EDS) in scanning transmission electron microscopy (STEM) has recently shown to be a powerful technique in analyzing the elemental identity and location of atomic columns in materials at atomic resolution. However, most applications of EDS STEM have been used only to qualitatively map whether elements are present at specific sites. Obtaining calibrated EDS STEM maps so that they are on an absolute scale is a difficult task and even if one achieves this, extracting quantitative information about the specimen – such as the number or density of atoms under the probe – adds yet another layer of complexity to the analysis due to the multiple elastic and inelastic scattering of the electron probe. Quantitative information may be obtained by comparing calibrated EDS STEM with theoretical simulations, but in this case a model of the structure must be assumed a priori. Here we first theoretically explore how exactly elastic and thermal scattering of the probe confounds the quantitative information one is able to extract about the specimen from an EDS STEM map. We then show using simulation how tilting the specimen (or incident probe) can reduce the effects of scattering and how it can provide quantitative information about the specimen. We then discuss drawbacks of this method – such as the loss of atomic resolution along the tilt direction – but follow this with a possible remedy: precession averaged EDS STEM mapping. - Highlights: • Signal obtained in EDS STEM maps (of STO) compared to non-channelling signal. • Deviation from non-channelling signal occurs in on-axis experiments. • Tilting specimen: signal close to non-channelling case but atomic resolution is lost. • Tilt-precession series: non-channelling signal and atomic-resolution features obtained. • Associated issues are discussed.

  14. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Liu, Chao, E-mail: liuchao9@mail.sysu.edu.cn [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Zhang, Hui [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China)

    2015-12-15

    Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.

  15. Plant immunity: the EDS1 regulatory node.

    Science.gov (United States)

    Wiermer, Marcel; Feys, Bart J; Parker, Jane E

    2005-08-01

    ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and its interacting partner, PHYTOALEXIN DEFICIENT 4 (PAD4), constitute a regulatory hub that is essential for basal resistance to invasive biotrophic and hemi-biotrophic pathogens. EDS1 and PAD4 are also recruited by Toll-Interleukin-1 receptor (TIR)-type nucleotide binding-leucine rich repeat (NB-LRR) proteins to signal isolate-specific pathogen recognition. Recent work points to a fundamental role of EDS1 and PAD4 in transducing redox signals in response to certain biotic and abiotic stresses. These intracellular proteins are important activators of salicylic acid (SA) signaling and also mediate antagonism between the jasmonic acid (JA) and ethylene (ET) defense response pathways. EDS1 forms several molecularly and spatially distinct complexes with PAD4 and a newly discovered in vivo signaling partner, SENESCENCE ASSOCIATED GENE 101 (SAG101). Together, EDS1, PAD4 and SAG101 provide a major barrier to infection by both host-adapted and non-host pathogens.

  16. 12MW Horns Rev experiment[Wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Hasager, C.B.; Pena, A; Mikkelsen, T.; Courtney, M.; Antoniou, I.; Gryning, S.-E.; Hansen, P. [Risoe National Lab., DTU, Wind Energy Dept. (Denmark); Soerensen, P.B. [DONG Energy (Denmark)

    2007-10-15

    The 12MW project with the full title '12 MW wind turbines: the scientific basis for their operation at 70 to 270 m height offshore' has the goal to experimentally investigate the wind and turbulence characteristics between 70 and 270 m above sea level and thereby establish the scientific basis relevant for the next generation of huge 12 MW wind turbines operating offshore. The report describes the experimental campaign at the Horns Rev offshore wind farm at which observations from Doppler Laser LIDAR and SODAR were collected from 3 May to 24 October 2006. The challenges for mounting and operating the instruments on the transformer platform at Horns Rev were overcome by a close collaboration between DONG energy and Risoe National Laboratory DTU. The site is presented. In particular, three tall offshore meteorological masts, up to 70 m tall, provided a useful source of meteorological data for comparison to the remotely sensed wind and turbulence observations. The comparison showed high correlation. The LIDAR and SODAR wind and turbulence observations were collected far beyond the height of the masts (up to 160 m above sea level) and the extended profiles were compared to the logarithmic wind profile. Further studies on this part of the work are on-going. Technical detail on LIDAR and SODAR are provided as well as theoretical work on turbulence and atmospheric boundary layer flow. Selected results from the experimental campaign are reported. (au)

  17. Comparative analysis of Rev function in human immunodeficiency virus types 1 and 2.

    OpenAIRE

    Garrett, E D; Cullen, B R

    1992-01-01

    The Rev proteins of the related but distinct human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) display incomplete functional reciprocity. One possible explanation for this observation is that HIV-2 Rev is unable to interact with the HIV-1 Rev-response element (RRE1). However, an analysis of the biological activity of chimeric proteins derived from HIV-1 and HIV-2 Rev reveals that this target specificity does not map to the Rev RNA binding domain but is instead primarily determined ...

  18. TED-Ed lessons & TED-Ed clubs: Educational activities to amplify students' voices

    Science.gov (United States)

    Villias, Georgios

    2017-04-01

    TED-Ed lessons and TED-Ed clubs are two powerful educational tools that can be used in today's school classrooms in order to create an educational environment that is engaging for the students and favors their active participation, created and fostered by TED-Ed. TED-Ed is TED's educational initiative, committed to create lessons worth sharing and amplify the voices and ideas of teachers and students around the world. TED-Ed animated lessons are fully organized lessons structured around an animated video that introduces new topics to learners in an exciting, thought-provoking way. These lessons have been created as a result of the cooperation between expert educators and animators and have been uploaded at the TED-Ed platform (http://ed.ted.com). On the other hand, TED-Ed Clubs are also an interesting way to offer students the chance, the voice and the opportunity to express their thoughts, engage actively on these matters and connect with each other, both at a local, as well as at an international level (http://ed.ted.com/clubs). By developing new TED-Ed lessons or by customizing appropriately existing animated TED-Ed lessons (translating, modifying the questions asked, introducing new discussion topics), I have created and implemented in my student-centered, didactic approach, a series of TED-ED animated lessons directly connected with the Greek national science syllabus that were used to spark students curiosity and initiate a further analytical discussion or introduce other relevant educational activities (http://gvillias.wixsite.com/education). Furthermore, at my school, we established Varvakeio TED-Ed Club, an environment that supports and empowers our students to research, develop and disseminate their own personal ideas that worth spreading. During the year, our members were inspired by watching TED talks presented by experts on their field on various different areas, including social, economical, environmental and technological-scientific issues. Our aim

  19. Analysis of the virulence-associated RevSR two-component signal transduction system of Clostridium perfringens.

    Science.gov (United States)

    Cheung, Jackie K; Wisniewski, Jessica A; Adams, Vicki M; Quinsey, Noelene S; Rood, Julian I

    2016-09-01

    Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that causes human gas gangrene (clostridial myonecrosis) and food poisoning. Early studies showed that virulence was regulated by the VirSR two-component signal transduction system. However, our identification of the RevR orphan response regulator indicated that more than one system was involved in controlling virulence. To further characterize this virulence-associated regulator, gel mobility shift experiments, coupled with DNase I footprinting, were used to identify the RevR DNA binding sequence. Bioinformatics analysis suggested that an orphan sensor histidine kinase, CPE1757 (renamed RevS), was the cognate sensor of RevR. Interaction between RevS and RevR was demonstrated by use of a bacterial two-hybrid system and validated by protein-protein interaction studies using biolayer interferometry. To assess the involvement of RevS in virulence regulation, the revS gene was inactivated by Targetron insertion. When isogenic wild-type, revS and complemented revS strains were tested in a mouse myonecrosis model, the revS mutant was found to be attenuated in virulence, which was similar to the attenuation observed previously with the revR mutant. However, transcriptional analysis of selected RevR-regulated genes in the revS mutant revealed a different pattern of expression to a revR mutant, suggesting that the RevSR system is more complex than originally thought. Taken together, the results have led to the identification and characterization of the two essential parts of a new regulatory network that is involved in the regulation of virulence in C. perfringens.

  20. Canadian EdGEO National Workshop Program

    Science.gov (United States)

    Clinton, L. A.; Haidl, F. M.; Hymers, L. A.; van der Flier-Keller, E.

    2009-05-01

    Established in the early 1970s, EdGEO supports locally driven geosciences workshops for Canadian teachers. Workshops are organized by geoscientists and teachers, and typically have field, laboratory and classroom components. Grants of up to $3000 per workshop are available from the National EdGEO Program. By providing educational opportunities for today's teachers and, through them, their students, EdGEO seeks to cultivate a heightened awareness of our planet. EdGEO workshops provide teachers with potential fieldtrip sites for their students and the knowledge, enthusiasm and materials to inspire their students to engage in geoscience. Networking opportunities with local experts promote the importance of the geoscience profession. The expected result is an improved capacity on the part of Canadians to understand the Earth and to make informed decisions, especially with regard to the use of mineral and energy resources, the maintenance and remediation of the environment, and response to geological hazards. There exists a critical need to provide teachers with training and resources to tackle their Earth science curricula. In 2008, EdGEO supported fourteen workshops, with an unprecedented 521 teachers attending. These teachers then used our resources to reach an estimated 14,000 students during that single academic year. EdGEO workshops are locally driven and are therefore very diverse. Workshops are strongly tied to the provincial curriculum, focus on a specific geoscience topic, or may be largely field-based to demonstrate and practice how field activities could be incorporated into Earth science teaching. Many strive to include all of these important components. Geoscientists and teachers work collaboratively to develop and deliver EdGEO workshops to ensure that the activities can be effectively used in the classroom. The length of these professional development opportunities range from two-hour sessions to several days, and can generally accommodate up to twenty

  1. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  2. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  3. Ed Deutschman Visit Images, May 2, 2011

    OpenAIRE

    Deutschman, Ed

    2011-01-01

    Background: Ed Deutschman was a Navy cadet at the Del Monte Pre-Flight School, located at the now (2013) Naval Postgraduate School. Mr Deutschman visited the Dudley Knox Library on May 2, 2011, and spoke about his service in World War II as a Corsair fighter pilot in the Pacific.

  4. Prospective study of violence against ED workers.

    Science.gov (United States)

    Kowalenko, Terry; Gates, Donna; Gillespie, Gordon Lee; Succop, Paul; Mentzel, Tammy K

    2013-01-01

    Health care support occupations have an assault-injury rate nearly 10 times the general sector. Emergency departments (EDs) are at greatest risk of such events. The objective was to describe the incidence of violence in ED health care workers (HCWs) over 9 months. Specific aims were to (1) identify demographic, occupational, and perpetrator factors related to violent events (VEs) and (2) identify predictors of acute stress in victims and predictors of loss of productivity. A longitudinal, repeated-methods design was used to collect monthly survey data from ED HCWs at 6 hospitals. Surveys assessed number and type of VEs, and feelings of safety and confidence. Victims also completed specific VE surveys. Descriptive statistics and a repeated-measure linear regression model were used. Two hundred thirteen ED HCWs completed 1795 monthly surveys and 827 VEs were reported. Average VE rate per person per 9 months was 4.15. Six hundred one events were physical threats (PTs) (3.01 per person). Two hundred twenty six events were assaults (1.13 per person). Five hundred one VE surveys were completed, describing 341 PTs and 160 assaults. Men perpetrated 63% of PTs and 52% of assaults. Significant differences in VEs were reported between registered nurses (RNs) and medical doctors (MDs) (P = .0017) and patient care assistants (P stress than the MDs (P stress reduced productivity (P stress, and lost productivity. Acute stress has negative consequences on workers' ability to perform their duties. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. Geology of outer Horns Rev, Danish North Sea

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Joern B.; Gravesen, P.; Lomholt, S. (Geological Survey of Denmark and Greenland, Copenhagen (Denmark))

    2008-07-15

    In 2006, Dong Energy initiated the development of the Horns Rev II offshore wind farm in the North Sea. In order to evaluate and map the characteristics of the surface features of the sea bed and to characterise the subsurface in the wind farm area, the Geological Survey of Denmark and Greenland (GEUS) conducted a geophysical survey of the area. The survey utilised a variety of instruments: sparker, side-scan sonar, marine caesium magnetometer and a multibeam echo-sounder. In addition, information on the subsurface sediments was obtained by cone penetration tests (CPT) and by drilling to 30-50 m below the sea bottom. Geological correlation of the CPT results with the other survey results was extremely complicated but was required in order to understand the architecture of the ice marginal glaciotectonic complex. Information on the geology is crucial for evaluation of the geotechnical problems of the region. (au)

  6. Ensemble-based Probabilistic Forecasting at Horns Rev

    DEFF Research Database (Denmark)

    Pinson, Pierre; Madsen, Henrik

    2009-01-01

    of probabilistic forecasts, the resolution of which may be maximized by using meteorological ensemble predictions as input. The paper concentrates on the test case of the Horns Rev wind form over a period of approximately 1 year, in order to describe, apply and discuss a complete ensemble-based probabilistic...... the benefit of yielding predictive distributions that are of increased reliability (in a probabilistic sense) in comparison with the raw ensemble forecasts, at the some time taking advantage of their high resolution. Copyright (C) 2008 John Wiley & Sons, Ltd....... are then converted into predictive distributions with an original adaptive kernel dressing method. The shape of the kernels is driven by a mean-variance model, the parameters of which ore recursively estimated in order to maximize the overall skill of obtained predictive distributions. Such a methodology has...

  7. Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome.

    Science.gov (United States)

    Singh, Bhupendra; Li, Xiurong; Owens, Kjerstin M; Vanniarajan, Ayyasamy; Liang, Ping; Singh, Keshav K

    2015-01-01

    To date, mitochondrial DNA polymerase γ (POLG) is the only polymerase known to be present in mammalian mitochondria. A dogma in the mitochondria field is that there is no other polymerase present in the mitochondria of mammalian cells. Here we demonstrate localization of REV3 DNA polymerase in the mammalian mitochondria. We demonstrate localization of REV3 in the mitochondria of mammalian tissue as well as cell lines. REV3 associates with POLG and mitochondrial DNA and protects the mitochondrial genome from DNA damage. Inactivation of Rev3 leads to reduced mitochondrial membrane potential, reduced OXPHOS activity, and increased glucose consumption. Conversely, inhibition of the OXPHOS increases expression of Rev3. Rev3 expression is increased in human primary breast tumors and breast cancer cell lines. Inactivation of Rev3 decreases cell migration and invasion, and localization of Rev3 in mitochondria increases survival and the invasive potential of cancer cells. Taken together, we demonstrate that REV3 functions in mammalian mitochondria and that mitochondrial REV3 is associated with the tumorigenic potential of cells.

  8. RNA-guided assembly of Rev-RRE nuclear export complexes.

    Science.gov (United States)

    Bai, Yun; Tambe, Akshay; Zhou, Kaihong; Doudna, Jennifer A

    2014-08-27

    HIV replication requires nuclear export of unspliced and singly spliced viral transcripts. Although a unique RNA structure has been proposed for the Rev-response element (RRE) responsible for viral mRNA export, how it recruits multiple HIV Rev proteins to form an export complex has been unclear. We show here that initial binding of Rev to the RRE triggers RNA tertiary structural changes, enabling further Rev binding and the rapid formation of a viral export complex. Analysis of the Rev-RRE assembly pathway using SHAPE-Seq and small-angle X-ray scattering (SAXS) reveals two major steps of Rev-RRE complex formation, beginning with rapid Rev binding to a pre-organized region presenting multiple Rev binding sites. This step induces long-range remodeling of the RNA to expose a cryptic Rev binding site, enabling rapid assembly of additional Rev proteins into the RNA export complex. This kinetic pathway may help maintain the balance between viral replication and maturation.DOI: http://dx.doi.org/10.7554/eLife.03656.001.

  9. REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells.

    Science.gov (United States)

    Wang, Wenjie; Sheng, Wenjiong; Yu, Chenxiao; Cao, Jianping; Zhou, Jundong; Wu, Jinchang; Zhang, Huojun; Zhang, Shuyu

    2015-09-01

    Lung cancer remains the leading cause of cancer-related mortality worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases of lung cancer. Cisplatin plays a significant role in the management of human lung cancer. Translesion DNA synthesis (TLS) is involved in DNA damage repair. DNA polymerase ζ (Pol ζ) is able to mediate the DNA replication bypass of DNA damage, which is suggested to be involved in chemoresistance. REV3L is the catalytic subunit of Pol ζ. Due to its critical role in translesion DNA synthesis, whether REV3L modulates cisplatin response in NSCLC cells remains unknown. In this study, REV3L overexpression and silencing H1299 cell lines were established. The reports showed that cisplatin induced the expression of REV3L by recruiting Sp1 to its promoter. Similar results were obtained when the ability of the cells to express luciferase from a platinated plasmid was measured. Co-transfection of the reporter with the REV3L overexpression vector or REV3L plus REV7L significantly enhanced the reporter activity. Nuclear condensation and fragmentation of shRNA-REV3L H1299 cells were more pronounced than shRNA-NC H1299 cells after cisplatin exposure, indicating that REV3L overexpression abolished cisplatin-induced DNA damage. Moreover, a forced expression of REV3L conferred the resistance of H1299 cells to cisplatin, whereas the knockdown of REV3L sensitized cisplatin efficacy in H1299 cells. Taken together, we demonstrated that inhibition of REV3L sensitized lung cancer H1299 cells to cisplatin treatment. Thus, REV3L may be a novel target for the chemotherapy of NSCLC.

  10. Cytoplasmic Streaming - Skylab Student Experiment ED-63

    Science.gov (United States)

    1973-01-01

    This chart describes the Skylab student experiment (ED-63), Cytoplasmic Streaming, proposed by Cheryl A. Peitz of Arapahoe High School, Littleton, Colorado. Experiment ED-63 was to observe the effect of zero-gravity on cytoplasmic streaming in the aquatic plant named Elodea, commonly called water weed or water thyme. The phenomenon of cytoplasmic streaming is not well understood, but it is recognized as the circulation mechanism of the internal materials or cytoplasm of a cell. Cytoplasm is a gelatinous substance that has the ability to change its viscosity and flow, carrying various cell materials with it. The activity can be stimulated by sunlight or heat. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

  11. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee at its meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  12. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  13. Suured fondid on varunud börsile mineva Teede REV-2 aktsiaid / Annika Matson

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2004-01-01

    Seoses Teede REV-2 aktsionäride kavaga aktsiate noteerimiseks Tallinna börsil 2005. aasta alguses, on Hansa Balti Kasvufond, Sampo Uus Euroopa Fond ja Ühispanga Kasvufond ostnud hallatavatesse investeerimisportfellidesse ehitusettevõtte aktsiaid. Diagrammid: Suure osa Teede REV-2 aktsiate omanikest tegevjuhid; Teede-Rev 2 ootab tänavu käibe kasvu. Kommenteerib Aivaras Abromavicius

  14. Case Study:EDS in China

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Asign that China is quickly moving up the global service outsourcing ranking came earlier this year when EDS (Electronic Data Services), one of the world's leading IT outsourcing companies,announced it would be moving its Asia headquarters to Shanghai from Australia. Recognizing the growing potential of China in this area, the company also announced it would shortly be launching at least two offshore software development centers in the country, with the first location due to be announced at the begining of November.

  15. Regional Energy Deployment System (ReEDS)

    Energy Technology Data Exchange (ETDEWEB)

    Short, W.; Sullivan, P.; Mai, T.; Mowers, M.; Uriarte, C.; Blair, N.; Heimiller, D.; Martinez, A.

    2011-12-01

    The Regional Energy Deployment System (ReEDS) is a deterministic optimization model of the deployment of electric power generation technologies and transmission infrastructure throughout the contiguous United States into the future. The model, developed by the National Renewable Energy Laboratory's Strategic Energy Analysis Center, is designed to analyze the critical energy issues in the electric sector, especially with respect to potential energy policies, such as clean energy and renewable energy standards or carbon restrictions. ReEDS provides a detailed treatment of electricity-generating and electrical storage technologies and specifically addresses a variety of issues related to renewable energy technologies, including accessibility and cost of transmission, regional quality of renewable resources, seasonal and diurnal generation profiles, variability of wind and solar power, and the influence of variability on the reliability of the electrical grid. ReEDS addresses these issues through a highly discretized regional structure, explicit statistical treatment of the variability in wind and solar output over time, and consideration of ancillary services' requirements and costs.

  16. DDX5 facilitates HIV-1 replication as a cellular co-factor of Rev.

    Directory of Open Access Journals (Sweden)

    Xiuxia Zhou

    Full Text Available HIV-1 Rev plays an important role in the late phase of HIV-1 replication, which facilitates export of unspliced viral mRNAs from the nucleus to cytoplasm in infected cells. Recent studies have shown that DDX1 and DDX3 are co-factors of Rev for the export of HIV-1 transcripts. In this report, we have demonstrated that DDX5 (p68, which is a multifunctional DEAD-box RNA helicase, functions as a new cellular co-factor of HIV-1 Rev. We found that DDX5 affects Rev function through the Rev-RRE axis and subsequently enhances HIV-1 replication. Confocal microscopy and co-immunoprecipitation analysis indicated that DDX5 binds to Rev and this interaction is largely dependent on RNA. If the DEAD-box motif of DDX5 is mutated, DDX5 loses almost all of its ability to bind to Rev, indicating that the DEAD-box motif of DDX5 is required for the interaction between DDX5 and Rev. Our data indicate that interference of DDX5-Rev interaction could reduce HIV-1 replication and potentially provide a new molecular target for anti-HIV-1 therapeutics.

  17. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.

    Science.gov (United States)

    Actis, Marcelo L; Ambaye, Nigus D; Evison, Benjamin J; Shao, Youming; Vanarotti, Murugendra; Inoue, Akira; McDonald, Ezelle T; Kikuchi, Sotaro; Heath, Richard; Hara, Kodai; Hashimoto, Hiroshi; Fujii, Naoaki

    2016-09-15

    DNA interstrand crosslink (ICL) repair (ICLR) has been implicated in the resistance of cancer cells to ICL-inducing chemotherapeutic agents. Despite the clinical significance of ICL-inducing chemotherapy, few studies have focused on developing small-molecule inhibitors for ICLR. The mammalian DNA polymerase ζ, which comprises the catalytic subunit REV3L and the non-catalytic subunit REV7, is essential for ICLR. To identify small-molecule compounds that are mechanistically capable of inhibiting ICLR by targeting REV7, high-throughput screening and structure-activity relationship (SAR) analysis were performed. Compound 1 was identified as an inhibitor of the interaction of REV7 with the REV7-binding sequence of REV3L. Compound 7 (an optimized analog of compound 1) bound directly to REV7 in nuclear magnetic resonance analyses, and inhibited the reactivation of a reporter plasmid containing an ICL in between the promoter and reporter regions. The normalized clonogenic survival of HeLa cells treated with cisplatin and compound 7 was lower than that for cells treated with cisplatin only. These findings indicate that a small-molecule inhibitor of the REV7/REV3L interaction can chemosensitize cells by inhibiting ICLR.

  18. Epistatic participation of REV1 and REV3 in the formation of UV-induced frameshift mutations in cell cycle-arrested yeast cells

    Energy Technology Data Exchange (ETDEWEB)

    Heidenreich, Erich [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)]. E-mail: erich.heidenreich@meduniwien.ac.at; Eisler, Herfried [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria); Steinboeck, Ferdinand [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)

    2006-01-29

    Mutations arising in times of cell cycle arrest may provide a selective advantage for unicellular organisms adapting to environmental changes. For multicellular organisms, however, they may pose a serious threat, in that such mutations in somatic cells contribute to carcinogenesis and ageing. The budding yeast Saccharomyces cerevisiae presents a convenient model system for studying the incidence and the mechanisms of stationary-phase mutation in a eukaryotic organism. Having studied the emergence of frameshift mutants after several days of starvation-induced cell cycle arrest, we previously reported that all (potentially error-prone) translesion synthesis (TLS) enzymes identified in S. cerevisiae did not contribute to the basal level of spontaneous stationary-phase mutations. However, we observed that an increased frequency of stationary-phase frameshift mutations, brought about by a defective nucleotide excision repair (NER) pathway or by UV irradiation, was dependent on Rev3p, the catalytic subunit of the TLS polymerase zeta (Pol {zeta}). Employing the same two conditions, we now examined the effect of deletions of the genes coding for polymerase eta (Pol {eta}) (RAD30) and Rev1p (REV1). In a NER-deficient strain background, the increased incidence of stationary-phase mutations was only moderately influenced by a lack of Pol {eta} but completely reduced to wild type level by a knockout of the REV1 gene. UV-induced stationary-phase mutations were abundant in wild type and rad30{delta} strains, but substantially reduced in a rev1{delta} as well as a rev3{delta} strain. The similarity of the rev1{delta} and the rev3{delta} phenotype and an epistatic relationship evident from experiments with a double-deficient strain suggests a participation of Rev1p and Rev3p in the same mutagenic pathway. Based on these results, we propose that the response of cell cycle-arrested cells to an excess of exo- or endogenously induced DNA damage includes a novel replication

  19. Wind Farm Wake: The Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Pierre-Elouan Réthoré

    2013-02-01

    Full Text Available The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surface temperature as well as ground-based information at and near the wind farm, including Supervisory Control and Data Acquisition (SCADA data. The SCADA data reveal that the case of fog formation occurred 12 February 2008 on the 10:10 UTC. The fog formation is due to very special atmospheric conditions where a layer of cold humid air above a warmer sea surface re-condensates to fog in the wake of the turbines. The process is fed by warm humid air up-drafted from below in the counter-rotating swirl generated by the clock-wise rotating rotors. The condensation appears to take place primarily in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog.

  20. H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation.

    Directory of Open Access Journals (Sweden)

    Fu-Ming Tsai

    Full Text Available H-rev107 is a member of the HREV107 type II tumor suppressor gene family and acts as a phospholipase to catalyze the release of fatty acids from glycerophospholipid. H-rev107 has been shown to play an important role in fat metabolism in adipocytes through the PGE2/cAMP pathway, but the detailed molecular mechanism underlying H-rev107-mediated lipid degradation has not been studied. In this study, the interaction between H-rev107 and cytochrome P450 reductase (POR, which is involved in hepatic lipid content regulation, was determined by yeast two-hybrid screen and confirmed by using in vitro pull down assays and immunofluorescent staining. The expression of POR in H-rev107-expressing cells enhanced the H-rev107-mediated release of arachidonic acid. However, H-rev107 inhibited POR activity and relieved POR-mediated decreased triglyceride content in HtTA and HeLa cervical cells. The inhibitory effect of H-rev107 will be abolished when POR-expressing cells transfected with PLA2-lacking pH-rev107 or treated with PLA2 inhibitor. Silencing of H-rev107 using siRNA resulted in increased glycerol production and reversion of free fatty acid-mediated growth suppression in Huh7 hepatic cells. In summary, our results revealed that H-rev107 is also involved in lipid accumulation in liver cells through the POR pathway via its PLA2 activity.

  1. 34 CFR 85.942 - ED Deciding Official.

    Science.gov (United States)

    2010-07-01

    ...) Definitions § 85.942 ED Deciding Official. The ED Deciding Official is an ED officer who has delegated authority under the procedures of the Department of Education to decide whether to affirm a suspension or enter a debarment. Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189), E.O. 12689 ( 3 CFR, 1989 Comp., p...

  2. edX e-learning course development

    CERN Document Server

    Gilbert, Matthew A

    2015-01-01

    If you are an educator creating a course for edX or a corporate trainer using Open edX for large-scale learning and development initiatives, then edX E-Learning Course Development is the ideal book for you.

  3. Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.

    Science.gov (United States)

    Han, Chang Woo; Jeong, Mi Suk; Jang, Se Bok

    2017-09-16

    Ras proteins are small GTPases that serve as master moderators of a large number of signaling pathways involved in various cellular processes. Activating mutations in Ras are found in about one-third of cancers. H-REV107, a K-Ras binding protein, plays an important role in determining K-Ras function. H-REV107 is a member of the HREV107 family of class II tumor suppressor genes and a growth inhibitory Ras target gene that suppresses cellular growth, differentiation, and apoptosis. Expression of H-REV107 was strongly reduced in about 50% of human carcinoma cell lines. However, the specific molecular mechanism by which H-REV107 inhibits Ras is still unknown. In the present study, we suggest that H-REV107 forms a strong complex with activating oncogenic mutation Q61H K-Ras from various biochemical binding assays and modeled structures. In addition, the interaction sites between K-Ras and H-REV107 were predicted based on homology modeling. Here, we found that some structure-based mutants of the K-Ras disrupted the complex formation with H-REV107. Finally, a novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Biological Characterization of CVRM2-BAC, A Recombinant CV1988 Virus Containing an REV LTR Insertion

    Science.gov (United States)

    It has been previously reported that avian retroviruses, i.e. avian leukosis virus (ALV) and reticoloendotheliosis virus (REV), integrate in the Marek’s disease virus genome affecting MDV pathogenicity. RM-2 is an attenuated serotype 1 MDV virus generated by insertion of the REV LTR in the genome of...

  5. 48 CFR 53.301-18 - SF 18 (Rev. 6/95), Request for Quotations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 18 (Rev. 6/95), Request for Quotations. 53.301-18 Section 53.301-18 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.301-18 SF 18 (Rev. 6/95),...

  6. 48 CFR 53.301-1414 - SF 1414 (Rev. 10/93) Consent of Surety.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 1414 (Rev. 10/93) Consent of Surety. 53.301-1414 Section 53.301-1414 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.301-1414 SF 1414 (Rev....

  7. Protective efficacy of a recombinant BAC clone of Marek's disease virus containing REV-LTR

    Science.gov (United States)

    Insertion of reticuloendotheliosis virus (REV) long-terminal repeat (LTR) into a bacterial artificial chromosome (BAC) clone of a very virulent strain of Marek’s disease (MD) virus (MDV), Md5 (Kim et al, 2011) rendered the resultant recombinant virus termed rMd5 REV-LTR BAC fully attenuated at passa...

  8. Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression.

    Directory of Open Access Journals (Sweden)

    Ariadna Amador

    Full Text Available The nuclear receptors REV-ERBα and REV-ERBβ are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes. The circadian rhythm is an endogenous mechanism, which generates entrainable biological changes that follow a 24-hour period. It regulates a number of physiological processes, including sleep/wakeful cycles and feeding behaviors. We recently demonstrated that REV-ERB-specific small molecules affect sleep and anxiety. The orexinergic system also plays a significant role in mammalian physiology and behavior, including the regulation of sleep and food intake. Importantly, orexin genes are expressed in a circadian manner. Given these overlaps in function and circadian expression, we wanted to determine whether the REV-ERBs might regulate orexin. We found that acute in vivo modulation of REV-ERB activity, with the REV-ERB-specific synthetic ligand SR9009, affects the circadian expression of orexinergic genes in mice. Long term dosing with SR9009 also suppresses orexinergic gene expression in mice. Finally, REV-ERBβ-deficient mice present with increased orexinergic transcripts. These data suggest that the REV-ERBs may be involved in the repression of orexinergic gene expression.

  9. La Costituzione Islandese: storia ed evoluzione

    Directory of Open Access Journals (Sweden)

    Fabio Quartino

    2011-03-01

    Full Text Available "La Costituzione Islandese: storia ed evoluzione" is a degree thesis defended on 15th July 2009 by Fabio Quartino under the supervision of Prof. Andrea Canepa of the University of Genoa, Italy. It offers an extensive overview of Icelandic history aimed at finding out the roots of the nation's constitutional order, which is currently in the process of being revised by the first ever elected constitutional assembly in the life of the country. Fabio Quartino's work wishes to be a source of useful information for Italian-speaking scholars who have an interest in Iceland's constitutional history and may not have access to comprehensive overviews in their native tongue.

  10. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3

    Energy Technology Data Exchange (ETDEWEB)

    Kula, Anna; Gharu, Lavina [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy); Marcello, Alessandro, E-mail: marcello@icgeb.org [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy)

    2013-01-20

    Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

  11. Diagnostic evaluation of degenerative and post-traumatic lesions of the spine and joints. 2. rev. ed.; Orthopaedisch-traumatologische Gelenk- und Wirbelsaeulendiagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Jerosch, J.; Castro, W.H.M. (eds.)

    2002-07-01

    This second, completely revised and updated edition in one volume offers the following advantages: It covers and explains all applicable diagnostic methods. - Differentiation between standard and special methods. - Guidance and pinpointed information explaining the performance of the methods, together with a systematic representation of indications. - Standard reporting forms, appearances and Scores. (orig./CB) [German] Unterscheidung von Standard- und Spezialuntersuchungen. Alle gaengigen Verfahren, auch viele Spezialverfahren, sind beruecksichtigt. Vorschlag von Untersuchungsgaengen fuer bestimmte Situationen. Detaillierte Beschreibung zur Durchfuehrung der einzelnen Verfahren. Gleichwertige Darstellung der klinischen Untersuchung. Nicht bekannte Tests und Techniken nachschlagen koennen. Indikationen fuer die einzelnen Verfahren werden systematisch dargestellt. Hinweise zum gezielten und Kosten sparenden Einsatz. Umfassende Information. In jedem Kapitel finden Sie Angaben zu: klinische Untersuchung einschliesslich Anamnese, Funktionspruefungen und neurologische Untersuchung. Roentgen, Sonographie, CT, MRT, Szintigraphie, - ggf. weitere spezielle Verfahren wie Arthrographie, Pedobarographie, Myelographie, Diskographie, Infiltrationsdiagnostik, Videorasterstereographie. Neu in der 2. Auflage - Jetzt zusammengefasst in einem Band - Diagnostik bei Endoprothesenlockerung - Standardisierte Befundungsboegen - Darstellung der gaengigen Gelenk-Scores. (orig.)

  12. Manual for thermography in civil engineering. Theory, application fields, realization in practice. 4. rev. and enl. ed.; Leitfaden Thermografie im Bauwesen. Theorie, Anwendungsgebiete, praktische Umsetzung

    Energy Technology Data Exchange (ETDEWEB)

    Fouad, Nabil A. [Hannover Univ. (Germany). Fakultaet fuer Bauingenieurwesen; Richter, Torsten [Hannover Univ. (Germany). Inst. fuer Bauphysik

    2012-07-01

    Passive thermography is a method for documentation of the surface temperature distribution in a building component. It is a fast and nondestructive method for localizing thermal shortcomings and building damage, provided that certain boundary conditions are maintained and external influencing factors considered. The authors present a concise summary of their experience with thermography in building construction. After an introduction to the physical fundamentals and an outline of current thermography systems, they present practical examples to illustrate the many applications of IR thermography as well as its limits. Important hints and preconditions for successful thermography are summarized in a short guide as well. [German] Mit Hilfe der passiven Thermografie kann die Oberflaechentemperaturverteilung eines Bauteils in Momentaufnahmen dokumentiert werden. Sie stellt damit eine zerstoerungsfreie und schnell einsetzbare Mess- und Untersuchungsmethode zur Lokalisierung von waermetechnischen Maengeln und Bauschaeden dar. Um aussagekraeftige Messergebnisse zu erhalten, sind allerdings einige Randbedingungen einzuhalten und aeussere Einflussgroessen zu beruecksichtigen. Die Autoren geben in komprimierter Form ihre Erfahrungen mit der Thermografie in der Bautechnik weiter. Nach einer Einfuehrung in die physikalischen Grundlagen und einem Ueberblick ueber die verschiedenen Thermografiesysteme zeigen sie anhand einer Vielzahl von Praxisbeispielen die vielfaeltigen Moeglichkeiten und Einsatzgebiete der Infrarot-Thermografie, aber auch ihre Anwendungsgrenzen auf. In einem Kurzleitfaden werden abschliessend wichtige Hinweise und Voraussetzungen fuer eine erfolgreiche Thermogrammerstellung zusammengefasst.

  13. L E E guide on electric power supply in high rise buildings. tot. rev. ed.; L E E. Leitfaden Elektrische Energie im Hochbau

    Energy Technology Data Exchange (ETDEWEB)

    Hennings, D.; Hinz, E.; Steinmueller, B.; Grossklos, M.

    2000-07-01

    Energy policy aiming at sustainability must take account of the noxious effects of fossil fuels. This guide will help to solve this problem. It is an easy to handle tool for integral planning and optimisation of electric power supply in administrative and office buildings, with a standard projecting procedure, a method for improving electric systems in buildings on the basis of characteristic values, and hints for planning and optimisation. It addresses builder owners and investors as well as architects, planners, engineers and energy consultants all of whom may be concerned in the planning of a building and its technical facilities. [German] Eine am Ziel der Nachhaltigkeit orientierte Energiepolitik muss Konsequenzen draus ziehen, dass der Einsatz der fossilen Energietraeger, auf denen unsere Energieversorgung bisher basiert, mit schaedlichen Umweltauswirkungen verbunden ist. Kohlendioxid und andere klimarelevante Spurengase heizen die Erdatmosphaere auf und drohen zur Klimakatastrophe zu fuehren; Stickoxid und Schwefeldioxid belasten mit dem sauren Regen Boden, Gewaesser und ganze Oekosysteme. Der vorliegende Leitfaden 'Elektrische Energie im Hochbau' will hier Abhilfe schaffen. Er stellt ein gut zu handhabendes Werkzeug dar, mit dessen Hilfe eine integrale Planung und Optimierung des rationellen Einsatzes elektrischer Energie in Dienstleistungsgebaeuden moeglich ist. Inhalte des Leitfadens sind die Darstellung des Planungsablaufs, ein Kennwertverfahren zur Verwertung und Verbesserung von elektrischen Anwendungen im Gebaeudebereich als Massnahme zur Investitions- und Betriebskostenreduzierung sowie Hinweise fuer Planung und Optimierung. Der Leitfaden richtet sich sowohl an die Bauherren bzw. Investoren als auch die an der Gebaeude- und Technikplanung Beteiligten, also die Architekten, Planer, Ingenieure und Energieberater. (orig.)

  14. Textbook on X-ray diagnostics. Substantiated by Marianne Zimmer-Brossy. 6. new rev. ed.; Lehrbuch der roentgendiagnostischen Einstelltechnik. Begruendet von Marianne Zimmer-Brossy

    Energy Technology Data Exchange (ETDEWEB)

    Becht, Stefanie [Unfallkrankenhaus Berlin (Germany). Inst. fuer Radiologie; Bittner, Roland C. [Helios Klinikum Emil von Behring, Berlin (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Ohmstede, Anke [Klinikum Oldenburg gGmbH (Germany). MTA-Schule; Pfeiffer, Andreas [Klinikum Stuttgart (Germany). Servicecenter Informationstechnik; Rossdeutscher, Reinhard [Johanniter-Krankenhaus im Flaeming, Treuenbrietzen (Germany). Abt. fuer Roentgendiagnostik

    2008-07-01

    The standard textbook on x-ray diagnostics has been revised by the MTRA team and radiologists: The book covers the following topics: General information: the profession of a radiologist, the x-ray department, radiation protection, quality assurance, basic physics, x-ray imaging, analog and digital image processing, archives, image interpretation. Skeleton diagnostics; Inner organs (thorax organs, neck, abdomen, gastrointestinal tract, colon, gall bladder and biliary tract): Special x-ray diagnostic methods: x-ray diagnostic of the female and male chest, x-ray diagnostics of bone joints (arthrography, and contrast media), x-ray diagnostics of the urinary-genital system, x-ray diagnostics of cavities and syrinx, x-ray diagnostics of arteries (arteriography, angiography), percutaneous transluminal angioplasty, x-ray diagnostics of veins (phlebography), x-ray diagnostics of lymphatic vessels and lymph nodes, x-ray diagnostics of spinal cord (myelography); Specific imaging methods: computerized tomography. [German] Ein erfahrenes Team aus MTRA und Radiologen ueberarbeitete und verbesserte das bewaehrte Standardwerk grundlegend. Detailliert, praezise und ausfuehrlich erlaeutert die 6. Neuauflage technische und physikalische Grundlagen, Strahlenschutz, alle wichtigen Einstellungen (vom Skelettsystem bis hin zur Mammadiagnostik) und aktuelle Leitlinien. Nah an der Praxis sind insbesondere die Hinweise zur Patientenvorbereitung und -lagerung, Qualitaetskriterien und Bildmerkmale sowie viele Tipps und Checklisten. Alle Einstellbilder sowie die Mehrzahl der radiologischen Aufnahmen sind erneuert. Die Kapitel zur digitalen Radiographie und den Grundlagen der MRT sind neu, die Kapitel zu CT-Protokollen und zur interventionellen Radiologie erweitert. Ein ausfuehrliches Glossar rundet das Buch ab. Insgesamt ein wertvolles und unverzichtbares Standardwerk fuer Ausbildung und Beruf. (orig.)

  15. Power energy. Systems for energy conversion. Compact knowledge for study and profession. 5. rev. and enl. ed.; Energietechnik. Systeme zur Energieumwandlung. Kompaktwissen fuer Studium und Beruf

    Energy Technology Data Exchange (ETDEWEB)

    Zahoransky, Richard A. (ed.); Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

    2010-07-01

    This textbook imparts to the reader a fundamental understanding for relations of energy conversion processes. It comprises the total spectra of energy engineering, starting with fundamentals of energy process engineering via description of operating power plants (all types) to energy distribution and - storage. Main topics are sustainable energy systems from renewable energy sources. combined systems (e.g. Gas/steam turbine power plants) and plants with cogeneration (e.g. modular cogeneration plants). A new chapter Kyoto-Protocol was created as a concept of emissions-free coal-fired power plants. A new wording for deregulation of energy markets was received. Numerous texts and graphs were been revised. Chapter 18 ''Deregulation of Energy Markets'' is newly revised. The 5th edition was actualized by new trends in energy engineering, chapter wind energy revised, and deregulation topics in the energy market extended. Due to its didactic concepts the book directs not only to students but also everybody, who is inerested into actual questions of energy engineering. (orig./GL)

  16. Diagnostic radiology of thoracic diseases. Textbook and atlas. 4. compl. rev. and enl. ed.; Radiologische Diagnostik der Thoraxerkrankungen. Lehrbuch und Atlas

    Energy Technology Data Exchange (ETDEWEB)

    Lange, Sebastian

    2010-07-01

    The book on diagnostic radiology of thoracic diseases covers the following topics: diagnostic techniques and normal diagnostic findings using x-ray radiography, CT, scintigraphy, angiography, bronchography, ultrasonography and NMR imaging; malformations; infections; emphysema, chronic lung diseases and asthma; inhalation damage and pneumoconiosis; neoplasm; vascular diseases; thorax injuries, pleura diseases, heart diseases, mediastinum diseases; midriff diseases; thoracic wall diseases; pathological pattern in CT; radiological indications and differential diagnostics; thoracic interventions.

  17. Production of rapeseed oil fuel in decentralized oil extraction plants. Handbook. 2. new rev. and enl. ed.; Herstellung von Rapsoelkraftstoff in dezentralen Oelgewinnungsanlagen. Handbuch

    Energy Technology Data Exchange (ETDEWEB)

    Remmele, Edgar [Technologie- und Foerderzentrum (TFZ) im Kompetenzzentrum fuer Nachwachsende Rohstoffe, Straubing (Germany)

    2009-11-15

    Increasing oil prices, the dependence on petroleum imports and the desire to reduce the CO{sub 2} emissions, are arguments to accelerate the production and utilization of biofuels. In 2007, 3.3 million tons of biodiesel and 772,000 tons of vegetable oil were used as fuel. The technically and economically successful production of rapeseed oil fuel in decentralized oil mills requires a quality assurance. Specifically, the brochure under consideration reports on the following: (1) Oilseed processing; (2) Centralized oil production in Germany; (3) Design of a decentralized oil mill; (4) Production of rapeseed oil fuel in decentralized systems; (5) Quality assurance for rapeseed oil fuel in decentralized oil mills; (6) Properties of rapeseed oil fuel; (7) Quality of rapeseed oil fuel from decentralized oil mills; (8) Economic aspects of decentralized oil extraction; (9) Legal framework conditions.

  18. Dictionary of electrical engineering, power engineering and automation. Pt. 2. English-German. 6. rev. and enl. ed.; Woerterbuch Elektrotechnik, Energie- und Automatisierungstechnik. T. 2. Englisch - Deutsch

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This dictionary can be recommended as the standard reference manual for translators, engineers, and technical writers who are looking for a comprehensive and reliable compilation of terms from the fields of power generation, transmission and distribution, drive engineering, automation, switchgear and installation engineering, power electronics as well as measurement and test engineering. For this edition, the dictionary has been updated and enlarged by about 40%. In the translation direction English-German, it now contains about 115,000 entries and 156,000 translations. The book is clearly structured, and the required information is quickly accessible (orig.)

  19. Dictionary of electrical engineering, power engineering and automation. Pt. 1. German-English. 6. rev. and enl. ed.; Woerterbuch Elektrotechnik, Energie- und Automatisierungstechnik. T. 1. Deutsch-Englisch

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This dictionary is the standard work for translators, engineers, and technical writers requiring a comprehensive and reliable compilation of terms from the fields of power generation, transmission and distribution, drive engineering, automation, switchgear and installation engineering, power electronics as well as measurement and test engineering. For this edition, the dictionary has been updated and enlarged by about 40 %. In the translation direction German-English (Volume 1), it now contains 121,000 entries and 166,000 translations, in the translation direction English-German 115,000 entries and 156,000 translations. (orig.)

  20. Manual for lightning protection and earthing. Electrical- and facility engineering. 5. tot. new rev. and enl. ed.; Handbuch fuer Blitzschutz und Erdung. Elektro- und Gebaeudetechnik

    Energy Technology Data Exchange (ETDEWEB)

    Hasse, P.; Wiesinger, J.; Zischank, W.

    2006-07-01

    Recent research and international lightning protection conferences (ICLP) and standardisation committees (IEC) brought about new findings on lightning protection which are considered in this 5th edition. The book outlines the history of lightning research and protection, the development of storm cells and lightning discharges, the incidence of lightning and warning, the electricity characteristics of earthborne lightnings, magnetic lightning fields, the electromagnetic field of the lightning path, the principles and types of lightning protectors, potential equalisation in lightning protection, lightning protection of electric and computer systems, magnetic shields, test methods and generators for lightning protection components and protectors, lightning protection of persons, and legal regulations on lightning protection in Germany. (orig./GL) [German] Aus aktuellen Forschungsergebnissen haben sich ebenso wie aus den internationalen Blitzschutzkonferenzen (ICLP) und Normungsgremien (IEC) neue, weiterfuehrende Aspekte der Blitzschutztechnik ergeben, die in der 5. Auflage dieses Buch ihren Niederschlag gefunden haben. Es befasst sich eingehend mit der Historie der Blitzforschung und des Blitzschutzes, der Entstehung von Gewitterzellen und Blitzentladungen, der Blitzhaufigkeit und Gewitterwarnung, den Stromkennwerten von Erdblitzen, den magnetischen Blitzfeldern, dem elektromagnetischen Feld des Blitzkanals, den Prinzipien des Blitzschutzes, den Fangeinrichtungen, Ableitungen und Erdungen, dem Blitzschutz-Potentialausgleich, dem Blitzschutz elektrischer und informationstechnischer Anlagen, den magnetischen Schirmen, den Pruefverfahren und -generatoren fuer Blitzschutz-Komponenten und -Schutzgeraete, dem Blitzschutz fuer Personen, den Blitzschutzbestimmungen in der Bundesrepublik Deutschland. (orig./GL)

  1. Pocket book of the metal trade. Vol. 1. Metals and trading conditions. 11. rev. ed.; Taschenbuch des Metallhandels. Bd. 1. Metalle und Handelsbedingungen

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Ralf (ed.); Dietz, Ferdinand; Kammer, Catrin; Mohr, Heinz; Zocher, Nadine

    2008-07-01

    Vol. 1 of the pocket book on metals and trading conditions comprises the following chapters: 1. Metal, a raw material; 2. Metal stock exchanges; 3. Trading conditions and standards; 4. Addresses, organisations, associations; 5. Metals dictionary D-E-F; 6. List of commodities for external trading; 7. Statistics (prices, production, consumption). [German] Der erste Band ueber Metalle und Handelsbedingungen ist in folgende Kapitel unterteilt: 1. Der Rohstoff Metall; 2. Die Metallboersen; 3. Handelsbedingungen/Normen; 4. Anschriften, Organisationen, Verbaende; 5. Metall Woerterbuch: Deutsch-Englisch Franzoesisch; 6. Warenverzeichnis fuer den Aussenhandel und 7. Statistik (Preis-, Produktions- und Verbrauchsstatistik).

  2. Thermodynamics for engineers. Text- and workbook for university students. 2. tot. rev. ed.; Thermodynamik fuer Ingenieure. Ein Lehr- und Arbeitsbuch fuer das Studium

    Energy Technology Data Exchange (ETDEWEB)

    Langeheinecke, K. [ed.; Jany, P. [Fachhochschule Ravensburg-Weingarten, Weingarten (Germany); Sapper, E. [Fachhochschule Konstanz (Germany)

    1999-07-01

    Technical thermodynamics is part of the basics of engineering. This book lays the foundation needed to understand the real thermal processes. Extensive explanations with a large number of diagrams, examples, problems and exercises illustrate the theory, philosophy, methods and tools of thermodynamics and make this book a valuable instrument of self-study. Specially taken into account is the imparting of technical terminology. The added CDrom presents computer codes for heat transfer, gas-vapor mixtures, combustion and material values, a formula collection THERMODYNAMIK MEMORY and an extensive alphabetic THERMODYNAMIK GLOSSAR. The content in brief: Sytems and their description, material properties, energy, the second fundamental sentence, ideal gases, gas- and gas-vapor-mixtures, heat engines, heat transfer and combustion. [German] Die Technische Thermodynamik gehoert zur Basis der Ingenieurwissenschaften. Das Buch vermittelt die Grundlagen fuer das Verstehen der realen thermischen Prozesse. Ausfuehrliche Texte mit vielen bildlichen Darstellungen, durchgerechnete Beispiele, zahlreiche Fragen und Uebungen verdeutlichen die Aussagen, Denkweisen, Methoden und Werkzeuge der Thermodynamik und empfehlen dieses Buch besonders zum Selbststudium. Besonderer Wert wird auf die Vermittlung der Fachsprache gelegt. Die beigefuegte CD-Rom bringt Rechenprogramme fuer Waermeuebertragung, Gas-Dampf-Gemische und Verbrennung sowie fuer Stoffwerte, die Formelsammlung THERMODYNAMIK MEMORY und das umfangreiche alphabetische THERMODYNAMIK GLOSSAR. Der Inhalt - die Systeme und ihre Beschreibung - Stoffeigenschaften - Energien - der zweite Hauptsatz - ideale Gase - Gas- und Gas-Dampf-Gemische - thermische Maschinen - Waermeuebertragung - Verbrennung. (orig.)

  3. Thermodynamics for engineers. Text- and workbook for university students. 7. rev. and enl. ed.; Thermodynamik fuer Ingenieure. Ein Lehr- und Arbeitsbuch fuer das Studium

    Energy Technology Data Exchange (ETDEWEB)

    Langeheinecke, Klaus (ed.); Jany, Peter; Thieleke, Gerd

    2008-07-01

    Technical thermodynamics is part of the basics of engineering. This book lays the foundation needed to understand the real thermal processes. Extensive explanations with a large number of diagrams, examples, problems and exercises illustrate the theory, philosophy, methods and tools of thermodynamics and make this book a valuable instrument of self-study. Specially taken into account is the imparting of technical terminology. The comprehensive index German-English aids reliably to find places in the book. In the Internet are available an interactive usable glossary, formula assembly Memory and also Index German-English. The content in brief: Sytems and their description, material properties, energy, the second fundamental sentence, ideal gases, gas- and gas-vapor-mixtures, heat engines, heat transfer and combustion. (orig./GL) [German] Die Technische Thermodynamik gehoert zur Basis der Ingenieurwissenschaften. Die zum Verstehen realer thermischer Prozesse erforderlichen Kenntnisse werden in diesem Lehrbuch mit ausfuehrlichen Texten, vielen aussagekraeftigen Abbildungen und durchgerechneten Beispielen vermittelt. Besonderer Wert wird auf die Fachsprache gelegt. Zahlreiche Fragen und Uebungen mit Loesungen unterstuetzen das Selbststudium. Das ausfuehrliche Sachwortverzeichnis deutsch-englisch hilft zuverlaessig beim Finden von Textstellen. Im Internet stehen ein interaktiv nutzbares Glossar, die Formelsammlung Memory und das Sachwortverzeichnis englisch-deutsch zur Verfuegung. Aktuell wurde die Qualitaet der Bilder verbessert und der Tabellenteil um weitere Zustandsgroessen ergaenzt. Aus dem Inhalt Die Systeme - Stoffeigenschaften - Energien - Prozesse - Zustandsgleichungen und Zustandsaenderungen Idealer Gase - Ideale Gas- und Gas-Dampf-Gemische - Klimatechnik - Energieumwandlung - Thermische Maschinen - Kaelte- und Kryotechnik - Brennstoffzellen - Waermeuebertragung - Verbrennung - Tabellen. (orig.)

  4. Normal values in growth and development. Base for diagnostics and therapy. 2. tot. rev. ed.; Normalwerte in Wachstum und Entwicklung. Die Basis fuer Diagnostik und Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Exner, G.U. [Abt. Kinderorthopaedie und Tumororthopaedie, Orthopaedische Universitaetsklinik Balgrist, Zurich (Switzerland)

    2003-07-01

    This compendium provides reference values and probability distributions on the following parameters: clinical and radiological measured values relating to the growing skeleton including: growth; hand skeleton development stages with Central European deviations; hip sonography; psychomotor development; performance physiology; and lung function. Newly incorporated in this edition are, amongst other features, explanations on the clinical significance of the measured values.

  5. Renewable energies in the primary school. Vol. 1. Energy (conservation). Solar energy. 2. rev. ed.; Erneuerbare Energien in der Grundschule. Bd. 1. Energie(sparen). Sonnenenergie

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, Astrid; Lueschen, Iris; Reimer, Monika [Oldenburg Univ. (Germany)

    2012-11-01

    The rearrangement of the energy supply to renewable energies is an issue of central importance for the future of our society. This rearrangement has to be supported by broad segments of the population in order to achieve the intended impact. Under this aspect, the authors of the contribution under consideration report on the item of renewable energy sources in primary schools. This contribution consists of the following chapters: (1) Why ''Renewable Energies'' in knowledge lessons? (Didactical orientation); (2) Aspects of science especially for girls (Didactical potentials); (3) Hints for the handling of the practice material; (4) Factual information and practice materials for the modules ''Energy conservation'' and ''Solar energy''.

  6. Disaster medicine. A guide for medical care in case of disasters; 4. rev. ed.; Katastrophenmedizin. Leitfaden fuer die aerztliche Versorgung im Katastrophenfall

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This is the fourth edition of a vademecum for medical experts in the Federal Republic of Germany, published by the Civil Defence Commission, an advisory body of the Federal Ministry of the Interior. The booklet is to help to provide and organize medical care in case of disasters, panic, mass injuries, radiation damage, poisoning and epidemics. There is a separate chapter on radiation accidents and radiation disasters as well as an appendix with a glossary of radiological terms and a list of radiation protection centers. (orig/MG) [Deutsch] Die Schutzkommission, ein Beratergremium beim Bundesminister des Innern, legt hiermit ein Vademecum fuer die Aerzte in der Bundesrepublik Deutschland in vierter Auflage vor. Es soll in Katastrophenfaellen helfen, beim Auftreten von Panik, Massenverletzungen, Strahlenschaeden, Vergiftungen und Seuchen das aerztlich Notwendige zu tun oder zu veranlassen. In einem Kapitel werden darin ausfuehrlich die aerztlichen Massnahmen bei Strahlenunfaellen und Strahlenkatastrophen beschrieben. Im Anhang findet sich ein radiologisches Glossar sowie eine Auflistung regionaler Strahlenschutzzentren. (orig./MG).

  7. Imaging mammary diagnostics. Diagnostic techniques, archetypical findings, differential diagnostcs and interventions.. 2. rev. and enl. ed.; Bildgebende Mammadiagnostik. Untersuchungstechnik, Befundmuster, Differenzialdiagnose und Interventionen. Kartonierte Sonderausgabe

    Energy Technology Data Exchange (ETDEWEB)

    Heywang-Koebrunner, S. [Martin-Luther-Univ., Halle-Wittenberg (Germany). Klinik fuer Diagnostische Radiologie; Schreer, I. (eds.) [Mamma-Zentrum des UK Kiel (Germany). Klinik fuer Geburtshilfe und Gynaekologie

    2008-07-01

    The book includes the following chapters: I. Methodology: anamnesis and interview; clinical evidence, mammography, sonography, magnetic resonance tomography, new imaging techniques (scintigraphy, PET), transcutaneous biopsy, pre-operative marking; II. phenotypes: normal mammary glands, mastopathics, cysts, benign tumors, inflammatory diseases, in-situ carcinomas, invasive carcinomas, lymphomas, other semi-malign and malign tumors, post-traumatic, post-surgical and post-therapeutic changes, skin changes, male mamma, screening, continuative diagnostics of screening evidence and problem solving for symptomatic patients.

  8. The engineering manual. Fundamentals and applications of mechanical engineering. 15. rev. and enl. ed.; Das Techniker Handbuch. Grundlagen und Anwendungen der Maschinenbau-Technik

    Energy Technology Data Exchange (ETDEWEB)

    Boege, A. [ed.

    1999-07-01

    With its many problems, images and examples, the book has long been a useful companion to students and a reliable reference manual for practicians, with an index for ready reference. Contents: Mathematics; Physics; Mechanics; Strength of materials; Materials science; Thermodynamics; Electrotechnics; Non-cutting forming; Cutting forming; Machine tools; Business economy; Engines and machines; Conveyance; Machine elements; Control engineering; CNC engineering; Programmed-storage control; Introduction to IEC 1131-3. The book has more than 1700 pages, with 1800 illustrations, 306 tables, and more than 3800 index terms for reference. [German] Das Buch ist mit seiner Problembeschreibung, den vielen Abbildungen und vertiefenden Beispielen eine seit vielen Jahren bewaehrte Lernhilfe im Studium. Mit ihr kann der aktuelle Unterrichtsstoff bei der Hausarbeit in Zusammenhaengen gesehen und verstaendlicher nachvollzogen werden. Das breite Themenspektrum garantiert beim Nachschlagen auch nach Jahren der Berufspraxis den sicheren Zugriff. Das ausfuehrliche Sachwortverzeichnis ist eine wertvolle Hilfe, wenn in Ausbildung oder Praxis nicht ausreichend bekannte Probleme angesprochen werden. Der Inhalt umfasst folgende Themen der Maschinenbau-Technik: - Mathematik - Physik - Mechanik - Festigkeitslehre - Werkstoffkunde - Waermelehre - Elektrotechnik - spanlose Fertigung - Zerspantechnik - Werkzeugmaschinen - Betriebswirtschaftslehre - Kraft- und Arbeitsmaschinen - Foerdertechnik - Maschinenelemente - Steuerungstechnik - CNC-Technik - Speicherprogrammierbare Steuerungen (SPS) und Einfuehrung in IEC 1131-3. Das Buch hat auf ueber 1700 Seiten 1800 Bildern, 306 Tafeln und mehr als 3800 Stichwoerter. (orig.)

  9. Practical control engineering. A textbook for mechanical and electrical engineers with emphasis on applications; 5. rev. ed.; Praktische Regeltechnik. Anwendungsorientierte Einfuehrung fuer Maschinenbauer und Elektrotechniker

    Energy Technology Data Exchange (ETDEWEB)

    Orlowski, P.F. [Fachhochschule Giessen-Friedberg, Giessen (Germany)

    1999-07-01

    The textbook is intended as an introduction to theory and practice, focusing on the latter, for students at colleges of technology specializing in application-related subjects as well as for practising engineers, and is designed so as to enable optimal learning efficacy. The author gives priority to practical engineering throughout the entire book, even in the chapters discussing fundamental aspects, so that most attention is given to concrete examples of practical tasks and problems encountered by and of most interest to engineers. A very extensive chapter discusses exclusively typical applications of control technology. Complementary to the exercises and solutions given in the textbook, there is a CD-ROM attached for follow-up training at home. The CD-ROM contains a training program with in-depth explanations and is suitable for users familiar with the mathematics problems of higher secondary education. Training tools exceeding this level are explained in full. (orig./CB) [Deutsch] Dies ist eine auf optimalen Lernerfolg ausgerichtete Einfuehrung fuer Studenten der praxisorientierten technischen Faecher und fuer Ingenieure im Beruf. Der fuer den Ingenieur so wichtige Blick auf die Anwendung steht, auch in den grundlegenden Kapiteln, stets im Vordergrund. Einen grossen Raum nehmen daher die konkreten Praxisbeispiele ein. So gibt es ein umfangreiches Kapitel, in dem ausschliesslich typische Anwendungen beschrieben werden. Zur Einuebung des Gelernten liegt - als sinnvolle Ergaenzung zu den zahlreichen Aufgaben und Loesungen im Buch - eine CD-ROM mit einem ausfuehrlich erlaeuterten Uebungsprogramm bei. Im allgemeinen genuegt zum Verstaendnis die uebliche Oberstufenmathematik, wo einmal nicht, werden die benoetigten Werkzeuge erklaert. (orig.)

  10. Further development of a method for assessing mine rescuers` heat tolerance. Final report; Rev. ed.; Weiterentwicklung eines Verfahrens zur Ermittlung der Waermevertraeglichkeit von Grubenwehrmitgliedern. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Bresser, G.; Kampmann, B.

    1997-08-01

    A test method was to be developed which permits reliable prediction of mine rescuers` heat tolerance. Apart from the anthropometric data like age, body weight and body size, further reference data were to be obtained from a standard test and a test of the rescuers` physical condition (Dynavit{sup R} test). These tests provide further parameters that may influence heat tolerance and which have been monitored both quantitatively and qualitatively for long years by the Central Mine Rescuing Authority. The description of stress incurred during the standard test and the heat test while wearing protective clothing will relate the criteria applied for the standard physical acceptance examination to the loads incurred during the tests. In order to take account of day-to-day variations of physical fitness, quarterly tests were carried out with four staff members, and performance variations were recorded. The results will serve as a basis for deciding on how rigid potential classification criteria should be applied. (orig./MG) [Deutsch] Es sollte ein Testverfahren entwickelt werden, das eine zuverlaessige Prognose der Waermevertraeglichkeit eines Grubenwehrmitgliedes zulaesst. Als Bezugsrahmen sollte die Beanspruchung bei der Standarduebung und das Abschneiden bei einem Konditionstest (Dynavit{sup R}-Test) zusaetzlich erfasst werden. Damit stehen - neben den anthropometrischen Daten wie Alter, Koerpergewicht und Koerpergroesse - weitere moegliche Einflussgroessen zur Abschaetzung der Hitzetauglichkeit zur Verfuegung, ueber deren Groesse und Verteilung langjaehrige Erfahrungen im Bereich der Hauptstelle fuer das Grubenrettungswesen vorliegen. Durch die Beschreibung der Beanspruchung der Grubenwehrmitglieder bei der Standarduebung und bei der Klimabelastung unter Flammenschutzkleidung sollen die Kriterien der Grubenwehrtauglichkeitsuntersuchung in Bezug zur Beanspruchung bei Uebungen gesetzt werden. Um die Schwankungen der Tagesform, die bei den Untersuchungen vorliegt, abschaetzen zu koennen, wurden mit vier Beschaeftigten vierteljaehrlich Uebungen durchgefuehrt. Dieser Untersuchungsteil soll Aufschluesse ueber die Frage geben, wie stark die Beanspruchung von Mal zu Mal schwankt, d.h. wie die individuelle Leistungsfaehigkeit und Waermevertraeglichkeit im Laufe der Zeit schwankt. Hieraus werden Ueberlegungen abgeleitet, wie scharf daher moegliche Klassierungskriterien angewendet werden koennen. (orig./MG)

  11. Clinical neuroanatomy and diagnostic imaging of the skull. Computerized tomography and nmr imaging. 2. rev. and enlarged ed. Klinische Neuroanatomie und kranielle Bilddiagnostik. Computertomographie und Magnetresonanztomographie

    Energy Technology Data Exchange (ETDEWEB)

    Kretschmann, H.J. (Medizinische Hochschule Hannover (Germany). Abt. Neuroanatomie); Weinrich, W. (Krankenhaus Nordstadt, Hannover (Germany). Neurologische Klinik)

    1991-01-01

    In the last few years, the techniques of CT, MRI, PET and utrasonography have been improved in their diagnostic efficiency, but in spite of the much enhanced resolution achievable with the new techniques, a large part of the neurofunctional systems that are of great significance to clinical diagnostic evaluation remains in the dark. The local structure of the neurofunctional systems is derived from the data describing the position of the conductive structures such as cerebral ventricles or typical cerebral sulci or gyri. A good knowledge of the three-dimensional topography of the neuroanatomy in the skull is required for this purpose, and this is what the book at hand is intended to confer. The arteries and their vascular environment are shown in the frontal, sagittal and axial plane and are compared with drawings produced from angiographies. The information given covers the cranium viscerale, the craniocervical neighbouring areas, and the motor innervation areas of the skull. The term 'diagnostic imaging of the skull' comprises the whole head and the transitional zones. The illustration of the neurofunctional system anatomy in the tomogram presented in this book is a source of information that may serve as a guide for pathfinding in CT, MRI, PET and ultrasonography. In addition, the knowledge found in the book will help to assign clinical data to pathologic findings revealed by CT or MRI. (orig.) With 596 mostly coloured figs.

  12. Safety and comfort systems with communication systems. Function, control, components. 3. new rev. and enl. ed.; Sicherheits- und Komfortsysteme: mit Kommunikationssystemen. Funktion, Regelung und Komponenten

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-10-15

    Safety systems like ESPL or airbag are of utmost importance for motorists. They identify danger situations without human assistance and trigger complex processes to prevent the danger or at least reduce their effects on the car passengers. Comfort systems facilitate the use of many functions inside the passenger compartment and make driving more comfortable and less stressful. The driver is free to attend to the needs of driving and traffic. Many such sytems were developed to maturity by Bosch. This book is a first-hand description of these important components of motor cars. The text is supplemented by many detailed drawings and pictures. Subjects: Fundamentals of driving physics; Brakes in passenger cars; Brake components in passenger cars; Antiblocking systems; Electronic stability programme; Adaptive speed control; Passenger protection systems; Driver assistant systems; Navigation systems; Traffic telematics. (orig.)

  13. Guideline for the tendering of the Europe-wide procurement of the electricity supply. 2. rev. ed.; Arbeitshilfe zur Durchfuehrung einer europaweiten Ausschreibung der Stromlieferung

    Energy Technology Data Exchange (ETDEWEB)

    Buchmueller, Christian [Schnutenhaus und Kollegen, Berlin (Germany)

    2013-05-02

    In order to describe the practical fundamentals for the procurement of electricity, the authors of this contribution present a guideline for the implementation of a Europe-wide tendering of the electricity supply. The main aspects of this contribution are the procedure and time schedule of the procurement procedure, preparation of the procurement procedure, design of the procurement procedure concerning to the contents as well as the implementation of the procurement procedure.

  14. We experience more than we comprehend. Quantum physics and questions of life. rev. new ed.; Wir erleben mehr als wir begreifen. Quantenphysik und Lebensfragen

    Energy Technology Data Exchange (ETDEWEB)

    Duerr, Hans-Peter; Oesterreicher-Mollwo, Marianne

    2015-07-01

    The quantum physics has been arrived by thinking and experimenting to revolutioning knowledges, which determine our world, also if only few have understood these theories in their real sense. The present book follows the question, whether and how far a consciousness trained by quantum physics can reach more directly to the understanding of questions of life and religious questions than a thinking, which is obliged to classical physics. It deals especially with fundamental existential questions: The theme of personal responsibility, the value of the individual existence, the evaluation of the personal I-you relation. Hans Peter Duerr, a personality with guiding qualities, as they are necessary in the new millennium, is the ideal speech partner for the dimension of this theme. The connections of natural sciences and religion, ecology, and sociological change have always driven the Heisenberg successor. How can we speech about that, which science cannot comprehend?. What means self, identity, responsibility for the quantum physicist? An exciting meeting.

  15. Strategy: The Logic of War and Peace rev. and enlarged ed. by Edward N. Luttwak Cambridge, MA: The Belknap Press of Harvard University Press, 2001 / Book Review

    OpenAIRE

    Wirtz, James J.

    2003-01-01

    In the 1980s scholars in the ªelds of history and political science rediscovered the work of Carl von Clausewitz, the Prussian philosopher of war. This renewed interest sparked a brief revival of the study of war and strategy (the latter of which encompasses efforts to exploit war’s dialectic to achieve military and political victory). After relying for decades on operations research to minimize the likelihood of nuclear war by bolstering deterrence—an approach that largely eli...

  16. Energy law. The legal boundary conditions of power supply. 2. rev. ed.; Grundriss zum Energierecht. Der rechtliche Rahmen fuer die Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Stuhlmacher, Gerd [E.ON Global Commodities SE, Duesseldorf (Germany); Stappert, Holger; Jansen, Guido (eds.) [Luther Rechtsanwaltsgesellschaft mbH, Duesseldorf (Germany); Schoon, Heike [BDEW Bundesverband der Energie- und Wasserwirtschaft e.V., Berlin (Germany)

    2015-11-01

    Now appearing in its second edition, this book presents a comprehensive overview of the legal framework governing the energy sector. It provides readily understandable coverage, across the relevant subfields of law, of the legal regulations applicable to any manner of activity in the energy sector along with a wealth of practical advice on the interpretation and application of legal provisions. The content has been thoroughly revised, updated to reflect the current status of legislation and supplemented with numerous chapters. The 2014 amendment of the Renewable Energy Law (EEG) and its practical impact have also been taken into account. The following topics are covered amongst others: unbundling of network operation; connection and access to networks and metering; network charges and incentive regulation; easement contracts; energy supply and basic services; energy and electricity taxes; cartel law, law on operating aids, procurement law; energy trade OTC and at exchanges; energy trade surveillance law; fuel production and fracking; conventional and nuclear power production; renewable energy production (including offshore production); energy storage and power-to-gas; transmission line construction; climate protection (including the 2014 EEG, emission trade and the Law on the Promotion of Renewable Energy in the Heat Sector); cogeneration law, district heating and contracting; and investment protection.

  17. Energy modernisation guide. Saving cost - improving value of houses - conserving resources. 3. rev. ed.; Modernisierungsratgeber Energie. Kosten sparen - Wohnwert steigern - Umwelt schonen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-12-15

    You are thinking of modernising your house and have a lot of questions? About what building measures to give priority? What technologies and materials to use? How to find a suitable craftsman or architect? What work you can as a DIY person? Where to obtain promotion funds for energy saving measures or innovative solar energy systems? For each of these questions the Energy Modernisation Guide has an answer. It provides you with detailed information and practical hints on everything concerning the modernisation of your house. We explain to you step by step what to look out for most - from planning to soliciting offers down to final acceptance. You will also learn what technical options there are for saving energy and how you can help to protect the climate and your own purse at the same time. We will advise on what work you can do yourself and what things are better left to a trained craftsperson. Last not least, we will provide you with detailed information on the many attractive promotional funds available for the energy refurbishment of buildings. (orig./GL) [German] Sie moechten Ihr Haus modernisieren und haben wahrscheinlich viele Fragen: Welche Baumassnahmen muessen vordringlich durchgefuehrt werden? Welche Technik und welche Materialien sollen verwendet werden? Wie finde ich geeignete Handwerker und Architekten? Welche Arbeiten kann ich als <> durchfuehren? Und von wem bekomme ich Foerdermittel fuer Energiesparmassnahmen oder innovative Solaranlagen? Auf all diese Fragen gibt Ihnen der Modernisierungsratgeber Energie Antwort. Er bietet Ihnen ausfuehrliche Informationen und praktische Hilfestellungen wenn es um die Modernisierung Ihres Hauses geht. Wir erlaeutern Ihnen Schritt fuer Schritt, worauf Sie besonders achten muessen - von der Planung ueber die Einholung von Angeboten bis zur Abnahme. Zudem erfahren Sie, welche technischen Moeglichkeiten es gibt, Energie einzusparen und wie Sie so das Klima schuetzen und Ihren Geldbeutel schonen koennen. Wir geben Ihnen Tipps, welche Arbeiten Sie selber durchfuehren koennen und welche Sie besser dem Fachhandwerker ueberlassen sollten. Und nicht zuletzt informieren wir ausfuehrlich ueber die zahlreichen attraktiven Foerdermoeglichkeiten fuer energetische Gebaeudeerneuerung. (orig.)

  18. Control engineering 1. Fundamentals, analysis and design of single-loop control systems. 6. new rev. ed.; Regelungstechnik 1. Systemtheoretische Grundlagen, Analyse und Entwurf einschleifiger Regelungen

    Energy Technology Data Exchange (ETDEWEB)

    Lunze, J. [Bochum Univ. (Germany). Lehrstuhl fuer Automatisierungstechnik und Prozessinformatik

    2007-07-01

    In terms of didactics, topic selection and focus this manual distinguishes itself from other introductions in the field of control technology. The author aims at a thorough understanding of dynamic systems and control processes with his presentation. He begins with time range evaluations in the status space and changes to frequency range presentation afterwards. Practical examples from the fields of electric engineering, machine engineering, process technology and traffic technology explain the application of the discussed methods and show the field-overlapping character of control technology. The introduction into MATLAB (version 7.3) is the link to the computer-supported work of engineers. Practice exercises with detailed solutions deepen the instruction syllabus. The description of MATLAB functions, which are useful for project tasks are supplemented in 6th edition. (orig.) [German] In Didaktik, Stoffauswahl und Schwerpunktsetzung unterscheidet sich dieses Lehrbuch von anderen Einfuehrungen in die Regelungstechnik. Der Autor zielt mit seiner Darstellung auf ein tiefgruendiges Verstaendnis dynamischer Systeme und Regelungsvorgaenge ab. So beginnt er mit Zeitbereichsbetrachtungen im Zustandsraum und geht erst danach zur Frequenzbereichsdarstellung ueber. Praktische Beispiele aus Elektrotechnik, Maschinenbau, Verfahrenstechnik und Verkehrstechnik illustrieren die Anwendung der behandelten Methoden und zeigen den fachuebergreifenden Charakter der Regelungstechnik. Die Einfuehrung in MATLAB (Version 7.3) stellt den Anschluss an die rechnergestuetzte Arbeitsweise von Ingenieuren her. Uebungsaufgaben mit ausfuehrlichen Loesungen vertiefen den Lehrstoff. In der 6. Auflage erweitert: die Beschreibung von MATLAB- Funktionen, die fuer Projektaufgaben nuetzlich sind. (orig.)

  19. NMR imaging of the vertebral column and the spinal canal. 2. rev. and enl. ed.; MRT der Wirbelsaeule und des Spinalkanals

    Energy Technology Data Exchange (ETDEWEB)

    Forsting, Michael [Universitaetsklinikum Essen (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie und Neuroradiologie; Uhlenbrock, Detlev [St.-Josefs-Hospital, Dortmund (Germany). MVZ Radiologie, Nuklearmedizin und Strahlentherapie; Wanke, Isabel [Privatklinikengruppe Hirslanden, Zurich (Switzerland); Universitaetsklinikum Essen (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie und Neuroradiologie

    2009-07-01

    The book on the MRT (magnetic resonance tomography) of the vertebral cord and spinal canal covers the following topics: physics fundamentals and application; malformation of the spinal canal; degenerative vertebral column diseases; vertebral column and spinal canal carcinomas; inflammatory diseases of the vertebral column and the spinal canal; applicability of MRT in case of acute spinal cord traumata; vascular diseases of the spinal canal.

  20. Solar water heating for residential buildings. With instructions for the construction of a thermosiphon system. 6. rev. ed. Solare Brauchwassererwaermung im Haushalt. Mit Hinweisen zum Selbstbau einer Schwerkraftanlage

    Energy Technology Data Exchange (ETDEWEB)

    Auer, F. (Ingenieurbuero NES Neue Energie-Systeme, Langenselbold (Germany))

    1991-01-01

    The use of solar energy for domestic water heating by flat plate collectors is today technically matured, such systems are easy to install and to operate as well as economic and competitive to other sources of energy. In this booklet the main components collector and storage system and the design as thermosiphon or pump system are described in detail. In the second part instructions for the self-construction of a thermosiphon system are given. Finally the economy of solar water heating systems is gone into. (BWI).

  1. Electric power plant technology. Generators, transformers, auxiliary installations, protective systems. Lecture notes. 5. rev. ed.; Elektrische Kraftwerkstechnik. Generatoren, Transformatoren, Eigenbedarfsanlagen, Schutzeinrichtungen. Vorlesungsskript

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Ulrich

    2009-07-01

    The lecture series on electric power plant engineering was initiated in 1969 by Prof. Helmut Schaefer, founder of the then department of power economy and power plant engineering. The lecture series was continuously updated in its contents and didactic approach, e.g. by integrating innovative power generation concepts like micro cogeneration plants and fuel cell systems. The focus is on the fundamentals and function of generators, main transformers, auxiliary installations and protective systems in power plant. Apart from the electrotechnical aspects, also aspects of mechanical engineering are gone into. Also discussed are energy conversion concepts fo renewable power generation plants like wind turbines and PV systems. This is the 5th, completely revised edition. It addresses primarily attendants of the lectures but may also serve as a textbook and reference manual for interested experts.

  2. Photovoltaic energy conversion: Power from the sun. Technology, economic efficiency, market trends. 4. rev. and act. ed.; Photovoltaik - Strom aus der Sonne. Technologie, Wirtschaftlichkeit und Marktentwicklung

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, J. (ed.)

    1999-07-01

    The book reviews the physical and technical fundamentals of photovoltaic energy conversion, outlines the state of the art and presents examples, and goes into future prospects. [German] Mit Photovoltaik-Systemen laesst sich aus Solarenergie besonders umweltfreundlich und wartungsarm Elektrizitaet erzeugen. Diese Technologie traegt zur Schonung der fossilen Energievorraete und zum Abbau von Risiken in der Energieversorgung bei. In vielen Faellen ist sie nicht nur die komfortablere, sondern auch die wirtschaftlichere Loesung. Sie bietet besonders in den Laendern der Dritten Welt sehr guenstige, noch zu wenig genutzte Moeglichkeiten der Energieversorgung. Schwerpunkte heutiger Forschung sind die Erhoehung des Wirkungsgrades, die Zuverlaessigkeit der Komponenten und die Reduzierung der Kosten. Wirtschaftlichkeit ist jedoch eines von mehreren Kriterien bei der Wahl der optimalen Energieversorgung. Andere Vorzuege der Photovoltaik wie Geraeusch- und Emissionsfreiheit, Zuverlaessigkeit und Wartungsarmut koennen in vielen Faellen von groesserer Bedeutung sein als reine Kostenueberlegungen. Dieser Band fuehrt in die physikalischen und technischen Grundlagen ein, beschreibt, auch anhand von zahlreichen Beispielen, den Stand der Anwendungstechnik und zeigt Zukunftsperspektiven auf. (orig.)

  3. Fundamentals of automatic control. A book without higher mathematics addressing a general auditorium; 3. rev. and enl. ed.; Elementare Regelungstechnik. Allgemeingueltige Darstellung ohne hoehere Mathematik

    Energy Technology Data Exchange (ETDEWEB)

    Busch, P. [Berufsschule Lueneburg (Germany)

    1995-12-31

    This book wants to help readers understand what happens in control systems without excessively complex mathematics. It addresses a broad range of readers, for instance, pupils and students at vocational grammar schools, technical schools and colleges. In addition, it is suited for continuing education - thanks to its numerous examples and exercises with solutions - and for self-study. As the practical side should not be neglected, each general consideration is followed by the calculation of a practical example. Furthermore, exercises with solutions are offered for self-control. Upon finishing the book, the reader should be able to analyze a controlled system according to automatic control criteria and to select and set a suitable controller. For complex controlled systems, the exact mathematical calculation would be too comprehensive. For such cases it is common in practice to make use of experimentally obtained approximations, which are equally described. The book has not only been thoroughly revised; a new chapter on fuzzy logic and its use in automatic control has been added (orig./GL) [Deutsch] Anliegen dieses Buches ist es, dem Leser die Zusammenhaenge in Regelkreisen verstaendlich zu machen, ohne dass die mathematischen Betrachtungen zu kompliziert werden. Angesprochen werden soll damit ein breiter Leserkreis, z.B. Schueler und Studierende an beruflichen Gymnasien, Fachschulen (Technikerschulen), Fachhochschulen. Das Buch ist aber auch geeignet fuer entsprechende Fortbildungsveranstaltungen sowie - dank der zahlreichen Beispiele und Uebungsaufgaben mit Loesungen - zum Selbststudium. Damit der praktische Aspekt nicht zu kurz kommt, wird nach jeder allgemeinen Betrachtung ein konkretes Beispiel berechnet. Zur Selbstkontrolle werden zusaetzlich Uebungsaufgaben mit Loesungen angeboten. Der Leser soll nach Studium des Buches in der Lage sein, eine Regelstrecke nach regelungstechnischen Kritieren zu analysieren und einen dafuer passenden Reglertyp auszuwaehlen und einzustellen. Bei komplizierten Strecken wuerde die exakte mathematische Berechnung zu umfangreich. Fuer diese Faelle wendet man in der Praxis experimentell gewonnene Naeherungsverfahren an, die in diesem Buch ebenfalls vorgestellt werden. Neben einer gruendlichen Ueberarbeitung des Buches wurde ein neues Kapitel ueber Fuzzy-Logik und deren Einsatz in der Regelungstechnik geschrieben. (orig./GL)

  4. Diagnostic imaging of the breast. Examination techniques, appearances, differential diagnosis and interventiones. 3. compl. rev. ed.; Bildgebende Mammadiagnostik. Untersuchungstechnik, Befundmuster, Differenzialdiagnose und Interventionen

    Energy Technology Data Exchange (ETDEWEB)

    Heywang-Koebrunner, Sylvia H. [Referenzzentrum Mammographie, Muenchen (Germany).; Schreer, Ingrid [Radiologische Allianz, Hamburg (Germany).

    2015-07-01

    The book on diagnostic imaging of the breast covers the following topics: Part I: Techniques: anamnesis and dialogue, clinical indications, mammography, sonography, nuclear magnetic resonance imaging, new imaging techniques, image clarification and percutaneous breast biopsy, preoperative marking. Part II: Appearance: the normal mamma, benign mamma modifications, cysts, benign tumors, inflammatory diseases, lesions with uncertain biological potential (B3 lesions), in-situ carcinoma, invasive carcinoma. Lymph nodes, other semi-malign and malign tumors, post-traumatic, post-operative and post-therapeutic changes, imaging diagnostics for breast implants, skin changes, the male breast. Part III: Use of imaging breast diagnostics: continuative diagnostics of screening indications and problem solution for the symptomatic patient.

  5. Foundations of physical chemistry. Vol. 3. Transport processes. 2. rev. and enlarged ed. Grundzuege der physikalischen Chemie in Einzeldarstellungen. Bd. 3. Transportvorgaenge

    Energy Technology Data Exchange (ETDEWEB)

    Haase, R. (Rheinisch-Westfaelische Technische Hochschule, Aachen (Germany)) (ed.)

    1987-01-01

    The book shall make students of chemistry, physics, processing techniques, and related fields - nearly on the level of the preparation for a main diploma examination - familiar with the methods and most important results of the research on the field of the transport processes. The volume is now present in second, revised, and extended edition. It treats the foundations as well as most important examples the conduction of electricity, the diffusion, the thermal conduction, and the internal friction, an appendix deals with the transport processes in electrolytic melts. The present book is the result of many-years experience in research and teaching. The ''Transport Processes'' are part of the ten-volume series Foundations of Physical Chemistry, which is especially suited as accompanying text for the course and for the examination preparation. (orig.).

  6. Paths of science. An introduction to science theorie. 5. tot. new rev. and enl. ed.; Wege der Wissenschaft. Einfuehrung in die Wissenschaftstheorie

    Energy Technology Data Exchange (ETDEWEB)

    Bergemann, N. [Heidelberg Univ. (Germany). Psychiatrische Klinik; Altstoetter-Gleich, C. (eds.) [Landau Univ. (Germany). Fachbereich Psychologie; Chalmers, A.F.

    2001-07-01

    Chalmers' critical reflections on schools of science theory has become a standard work in academic teaching which has been translated into 15 languages. It owes its popularity to Chalmers' manner of presenting this complex subject in an easily understandable way using a wealth of illustrative examples. This tradition has been preserved in the present completely revised edition, which again has been supplemented by a number of chapters. In addition to providing an outstanding overview of classical approaches to science theory, i.e. inductionism, critical rationalism and falsificationism, and presenting the theories of Karl Popper, Imre Lakatos, Thomas Kuhn and Paul Feyerabend it also deals with more recent developments in science theory. Special emphasis is placed on the 'new experimentalism', the stochastic approach of Thomas Bayes, the nature of the laws of natural science and the current realism versus antirealism debate. [German] Chalmers kritische Reflexion ueber wissenschaftstheoretische Schulen ist zu einem Standardwerk universitaerer Lehre avanciert, das inzwischen in ueber 15 Sprachen uebersetzt wurde. Seine Popularitaet verdankt das Buch der Tatsache, dass es Chalmers gelingt, die komplexe Thematik in eine auch fuer Laien verstaendliche Form zu bringen und mit zahlreichen Beispielen zu illustrieren. In dieser voellig ueberarbeiteten und erneut um einige Kapitel erweiterten Auflagen bleibt Chalmers dieser Tradition treu. Es bietet nicht nur einen hervorragenden Ueberblick ueber klassische Ansaetze der Wissenschaftstheorie, den Induktivismus, den kritischen Rationalismus sowie den Falsifikationismus und stellt die Theorien von Karl Popper, Imre Lakatos, Thomas Kuhn und Paul Feyerabend vor, sondern geht auch auf neuere wissenschaftstheoretische Entwicklungen ein. Sein besonderes Augenmerk gilt dabei der Bedeutung des Experiments und dem 'Neuen Experimentalismus', dem wahrscheinlichkeitstheoretischen Ansatz von Thomas Bayes, dem Wesen naturwissenschaftlicher Gesetze sowie der aktuellen 'Realismus versus Anti-Realismus-Debatte'.

  7. Skeletal diseases. Diagnostic clinical radiology and differential diagnostics. 3. new rev. and enl. Ed.; Skeletterkrankungen. Klinisch-radiologische Diagnose und Differenzialdiagnose

    Energy Technology Data Exchange (ETDEWEB)

    Freyschmidt, J. [Klinikum Bremen-Mitte gGmbH, Bremen (Germany). Beratungsstelle und Referenzzentrum fuer Osteoradiologie

    2008-07-01

    The book covers the following topics: introduction into the osteoradiology, traumatisized bones, perfusion disturbances of bones and bone marrow, congenital and late sklerosient and hyperstotic skeletal changes, changes of the bone metabolism, skeletal changes due to different diseases, infectious and non-infectious skeletal diseases, vascular anomalies, perostal changes, primary and secondary bone tumors, tumor-like lesions. [German] Klare Struktur, praegnante Texte und hervorragende Abbildungen. Das vollstaendige Nachschlagewerk zu allen systemischen Skelett- und Gelenkerkrankungen. Aktuelle Erkenntnisse und neues Bildmaterial. Neues Kapitel: nichttumoroese Weichgewebserkrankungen. Synoptische Betrachtung klinischer und aller einsetzbaren bildgebenden Diagnoseverfahren inklusive MR und Skelettszintigraphie. Die klinischen Ansprueche an die Leistungsfaehigkeit der bildgebenden Diagnostik sind in den letzten Jahren gewaltig gewachsen. Die vollstaendig ueberarbeitete dritte Auflage der Skeletterkrankungen beruecksichtigt die aktuellen Erkenntnisse, vor allem im Hinblick auf neue Entitaeten und den sinnvollen Einsatz moderner Schnittbildverfahren. Entsprechend wurden die Abbildungen aktualisiert und durch neues Bildmaterial erweitert. Grundlegend neu bearbeitet sind unter anderem die Kapitel ueber die radiologische Untersuchungstechnik inkl. Befundinterpretation, Stressphaenomene, Perfusionsstoerungen, vaskulaere Anomalien, entzuendliche und rheumatische Erkrankungen, Knochentumoren sowie AIDS-assoziierte Skelettveraenderungen. Ein neues Kapitel beschaeftigt sich mit nichttumoroesen Weichgewebserkrankungen, denen der Radiologe heute immer haeufiger begegnet. Die klare Kapitelstruktur, praegnanten Texte und hervorragenden Abbildungen machen den 'Freyschmidt' zum unverzichtbaren Kompendium fuer die radiologische Praxis. (orig.)

  8. Rev1 is a base excision repair enzyme with 5′-deoxyribose phosphate lyase activity

    Science.gov (United States)

    Prasad, Rajendra; Poltoratsky, Vladimir; Hou, Esther W.; Wilson, Samuel H.

    2016-01-01

    Rev1 is a member of the Y-family of DNA polymerases and is known for its deoxycytidyl transferase activity that incorporates dCMP into DNA and its ability to function as a scaffold factor for other Y-family polymerases in translesion bypass events. Rev1 also is involved in mutagenic processes during somatic hypermutation of immunoglobulin genes. In light of the mutation pattern consistent with dCMP insertion observed earlier in mouse fibroblast cells treated with a base excision repair-inducing agent, we questioned whether Rev1 could also be involved in base excision repair (BER). Here, we uncovered a weak 5′-deoxyribose phosphate (5′-dRP) lyase activity in mouse Rev1 and demonstrated the enzyme can mediate BER in vitro. The full-length Rev1 protein and its catalytic core domain are similar in their ability to support BER in vitro. The dRP lyase activity in both of these proteins was confirmed by NaBH4 reduction of the Schiff base intermediate and kinetics studies. Limited proteolysis, mass spectrometry and deletion analysis localized the dRP lyase active site to the C-terminal segment of Rev1's catalytic core domain. These results suggest that Rev1 could serve as a backup polymerase in BER and could potentially contribute to AID-initiated antibody diversification through this activity. PMID:27683219

  9. Structural model of the Rev regulatory protein from equine infectious anemia virus.

    Directory of Open Access Journals (Sweden)

    Yungok Ihm

    Full Text Available Rev is an essential regulatory protein in the equine infectious anemia virus (EIAV and other lentiviruses, including HIV-1. It binds incompletely spliced viral mRNAs and shuttles them from the nucleus to the cytoplasm, a critical prerequisite for the production of viral structural proteins and genomic RNA. Despite its important role in production of infectious virus, the development of antiviral therapies directed against Rev has been hampered by the lack of an experimentally-determined structure of the full length protein. We have used a combined computational and biochemical approach to generate and evaluate a structural model of the Rev protein. The modeled EIAV Rev (ERev structure includes a total of 6 helices, four of which form an anti-parallel four-helix bundle. The first helix contains the leucine-rich nuclear export signal (NES. An arginine-rich RNA binding motif, RRDRW, is located in a solvent-exposed loop region. An ERLE motif required for Rev activity is predicted to be buried in the core of modeled structure where it plays an essential role in stabilization of the Rev fold. This structural model is supported by existing genetic and functional data as well as by targeted mutagenesis of residues predicted to be essential for overall structural integrity. Our predicted structure should increase understanding of structure-function relationships in Rev and may provide a basis for the design of new therapies for lentiviral diseases.

  10. Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation

    Directory of Open Access Journals (Sweden)

    Jun Takezawa

    2010-01-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a lesion on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion, extend by a few nucleotides, and dissociate from the 3′-OH. The replicative polymerase then resumes DNA synthesis. This process, termed translesion replication (TLS or replicative bypass, may involve at least five different polymerases in mammals, although the participating polymerases and their roles have not been entirely characterized. Using siRNAs originally designed and an alkaline sucrose density gradient sedimentation technique, we verified the involvement of several polymerases in ultraviolet (UV light-induced TLS in HeLa cells. First, siRNAs to Rev3 or Rev7 largely abolished UV-TLS, suggesting that these 2 gene products, which comprise Polζ, play a main role in mutagenic TLS. Second, Rev1-targeted siRNA also abrogated UV-TLS, indicating that Rev1 is also indispensable to mutagenic TLS. Third, Polη-targeted siRNA also prevented TLS to a greater extent than our expectations. Forth, although siRNA to Polι had no detectable effect, that to Polκ delayed UV-TLS. To our knowledge, this is the first study reporting apparent evidence for the participation of Polκ in UV-TLS.

  11. Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells

    Energy Technology Data Exchange (ETDEWEB)

    Ramakrishnan, Sathiya N.; Lau, Patrick; Crowther, Lisa M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cleasby, Mark E. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Millard, Susan; Leong, Gary M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cooney, Gregory J. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Muscat, George E.O., E-mail: g.muscat@imb.uq.edu.au [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia)

    2009-10-30

    The nuclear hormone receptor, Rev-erb beta operates as a transcriptional silencer. We previously demonstrated that exogenous expression of Rev-erb{beta}{Delta}E in skeletal muscle cells increased Srebp-1c mRNA expression. We validated these in vitro observations by injection of an expression vector driving Rev-erb{beta}{Delta}E expression into mouse tibialis muscle that resulted in increased Srebp-1c mRNA expression. Paradoxically, Rev-erb{beta} siRNA expression in skeletal muscle cells repressed Srebp-1c expression, and indicated that Rev-erb{beta} expression was necessary for Srebp-1c expression. ChIP analysis demonstrated that Rev-erb{beta} was recruited to the Srebp-1c promoter. Moreover, Rev-erb{beta} trans-activated the Srebp-1c promoter, in contrast, Rev-erb{beta} efficiently repressed the Rev-erb{alpha} promoter, a previously characterized target gene. Finally, treatment with the Rev-erb agonist (hemin) (i) increased the trans-activation of the Srebp-1c promoter by Rev-erb{beta}; and (ii) increased Rev-erb{beta} and Srebp-1c mRNA expression. These data suggest that Rev-erb{beta} has the potential to activate gene expression, and is a positive regulator of Srebp-1c, a regulator of lipogenesis.

  12. Citar e referenciar : APA 6ª ed.

    OpenAIRE

    Marcos, Isabel Marques

    2016-01-01

    A elaboração correta dos trabalhos científicos pressupõe o respeito por um conjunto de princípios normativos de citação e referenciação bibliográfica que salvaguardam os autores das criações intelectuais do uso indevido das mesmas. Partindo de três conceitos: citação, referência bibliográfica e lista de referências apresentam-se as normas da APA 6ª ed. nos seus elementos essenciais. Estas normas, da área da informação e documentação, definem regras para a normalização das referências bibliogr...

  13. Pareto vs Simmel: residui ed emozioni

    Directory of Open Access Journals (Sweden)

    Silvia Fornari

    2017-08-01

    Full Text Available A cento anni dalla pubblicazione del Trattato di sociologia generale (Pareto 1988 siamo a mantenere vivo ed attuale lo studio paretiano con una rilettura contemporanea del suo pensiero. Ricordato per la grande versatilità intellettuale dagli economisti, rimane lo scienziato rigoroso ed analitico i cui contributi sono ancora discussi a livello internazionale. Noi ne analizzeremo gli aspetti che l’hanno portato ad avvicinarsi all’approccio sociologico, con l’introduzione della nota distinzione dell’azione sociale: logica e non-logica. Una dicotomia utilizzata per dare conto dei cambiamenti sociali riguardanti le modalità d’azione degli uomini e delle donne. Com’è noto le azioni logiche sono quelle che riguardano comportamenti mossi da logicità e raziocinio, in cui vi è una diretta relazione causa-effetto, azioni oggetto di studio degli economisti, e di cui non si occupano i sociologi. Le azioni non-logiche riguardano tutte le tipologie di agire umano che rientrano nel novero delle scienze sociali, e che rappresentano la parte più ampia dell’agire sociale. Sono le azioni guidate dai sentimenti, dall’emotività, dalla superstizione, ecc., illustrate da Pareto nel Trattato di sociologia generale e in saggi successivi, dove riprende anche il concetto di eterogenesi dei fini, formulato per la prima volta da Giambattista Vico. Concetto secondo il quale la storia umana, pur conservando in potenza la realizzazione di certi fini, non è lineare e lungo il suo percorso evolutivo può accadere che l’uomo nel tentativo di raggiungere una finalità arrivi a conclusioni opposte. Pareto collega la definizione del filosofo napoletano alle tipologie di azione sociale e alla loro distinzione (logiche, non-logiche. L’eterogenesi dei fini per Pareto è dunque l’esito di un particolare tipo di azione non-logica dell’essere umano e della collettività.

  14. Contribution of ED admissions to inpatient hospital revenue.

    Science.gov (United States)

    Sacchetti, Alfred; Harris, Russell H; Warden, Todd; Roth, Sandra

    2002-01-01

    Emergency department (ED) practices are traditionally profiled in terms of their patient encounters. Such evaluations reflect a preponderance of outpatient visits while crediting income from admitted patients to traditional hospital-based services. This study evaluates the contribution of ED admissions to inpatient hospital revenue. The study was set at an urban tertiary care community hospital with university affiliation. Information referable to ED patients was collected from the hospital's Universal Billing Code (UB-92)-based patient information warehouse. Data fields referable to hospital charges, insurance type, and disposition were used for analysis of a 1-year period from September 1, 1998 to August 31, 1999. Statistical analysis was through chi square and ANOVA. During the study period 33,174 patients were treated in the ED with 6,671 (20%) admitted to inpatient services. Total hospital charges for all ED patients during this time were $107 million dollars with $9.1 million (8.5%) generated from discharged patients and $98.0 million (91.5%) from admitted ED patients (P revenue for inpatient services for the study period was $288 million of which 34% was contributed from admitted ED patients. ED services represent a major source of inpatient hospital revenue. The recognition of the ED's potential in this area may be lost if income from patients admitted through the ED is credited to traditional hospital-based services.

  15. Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

    Directory of Open Access Journals (Sweden)

    Ryan D. Welch

    2017-07-01

    Conclusions: Disrupting Rev-Erb activity in injured muscle accelerates regenerative muscle repair/differentiation through transcriptional de-repression of myogenic programs. Rev-Erb, therefore, may be a potent therapeutic target for a myriad of muscular disorders.

  16. Technical Analysis of IEC 61850 Ed 2.0%IEC 61850 Ed 2.0技术分析

    Institute of Scientific and Technical Information of China (English)

    任雁铭; 操丰梅; 张军

    2013-01-01

    对IEC 61850 Ed 2.0的文件构成和技术路线进行了介绍.对比IEC 61850 Ed 1.0,从数据模型、工程配置语言和一致性测试3个方面,对IEC 61850 Ed 2.0的技术特点进行了技术分析.从设备制造商和检测中心2个方面,讨论了如何从IEC 61850 Ed 1.0迁徙到IEC 61850 Ed 2.0.%The profile and technical philosophy of IEC 61850 Ed 2.0 are described. By comparison with IEC 61850 Ed 1.0, an analysis is made of the technical features of IEC 61850 Ed 2.0 data model, substation configuration language and conformance test. A discussion is made of shifting from IEC 61850 Ed 1.0 to IEC 61850 Ed 2.0 with respect to the manufacturer and testing organization.

  17. Structured classification for ED presenting complaints – from free text field-based approach to ICPC-2 ED application

    Directory of Open Access Journals (Sweden)

    Malmström Tomi

    2012-11-01

    Full Text Available Abstract Background Although there is a major need to record and analyse presenting complaints in emergency departments (EDs, no international standard exists. The aim of the present study was to produce structured complaint classification suitable for ED use and to implement it in practice. The structured classification evolved from a study of free text fields and ICPC-2 classification. Methods Presenting complaints in a free text field of ED admissions during a one-year period (n=40610 were analyzed and summarized to 70 presenting complaint groups. The results were compared to ICPC-2 based complaints collected in another ED. An expert panel reviewed the results and produced an ED application of ICPC-2 classification. This study implemented the new classification into an ED. Results The presenting complaints summarized from free text fields and those from ICPC-2 categories were remarkably similar. However, the ICPC-2 classification was too broad for ED; an adapted version was needed. The newly developed classification includes 89 presenting complaints and ED staff found it easy to use. Conclusions ICPC-2 classification can be adapted for ED use. The authors suggest a list of 89 presenting complaints for use in EDs adult patients.

  18. Take steps to curb violence, improve safety for ED personnel.

    Science.gov (United States)

    2011-10-01

    While violent eruptions are well documented in the ED, there is a not a lot of research into what strategies are most effective at both curbing violence and managing incidents when they do occur. Experts suggest that ED managers should consider staff training and visible security measures when developing procedures for dealing with violence. In one survey of ED physicians, more than three-quarters reported at least one incident of workplace violence in the previous 12 months. Researchers report that many EDs post security at the point of entry, but lack security coverage in patient care areas. Experts suggest that verbal de-escalation techniques can be helpful in lowering anxiety levels.They also urge ED managers to bring in assistance when the ED is crowded or waiting times are long.

  19. Teede REV-2 otsustas börsile minna / Gea Velthut-Sokka

    Index Scriptorium Estoniae

    Velthut-Sokka, Gea, 1977-

    2004-01-01

    Eelmise aasta edukaima ehitusfirma Teede REV-2 ja tema suurinvestori Alta Kapital esindajad põhjendavad börsile mineku otsust. Tabelid ja diagrammid: Veerandi aktsiate omanikuvahetus börsilemineku peaprooviks

  20. Rev. Konstanty Michalski's life and work. On his 50th anniversary of death

    Directory of Open Access Journals (Sweden)

    Stanisław Piech

    1998-12-01

    Full Text Available The article outlines the life and work of Rev. Konstanty Michalski, a lecturer at the Department of Theology at the Jagiellonian University, on the fiftieth anniversary of his death (deceased in 1947.

  1. Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates

    NARCIS (Netherlands)

    E. Sonoda (Eiichiro); S. Takeda (Shiunichi); T. Okada (Takashi); G.Y. Zhao (Guang); S. Tateishi (Satoshi); K. Araki (Kasumi); M. Yamaizumi (Masaru); T. Yagi (Takashi); N.S. Verkaik (Nicole); D.C. van Gent (Dik); M. Takata (Minoru)

    2003-01-01

    textabstractTranslesion DNA synthesis (TLS) and homologous DNA recombination (HR) are two major postreplicational repair (PRR) pathways. The REV3 gene of Saccharomyces cerevisiae encodes the catalytic subunit of DNA polymerase zeta, which is involved in mutagenic TLS. To

  2. 78 FR 27971 - Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not...

    Science.gov (United States)

    2013-05-13

    ... HUMAN SERVICES Food and Drug Administration Determination That REV-EYES (Dapiprazole Hydrochloride... determined that REV-EYES (dapiprazole hydrochloride ophthalmic solution), 0.5%, was not withdrawn from sale... refer to a listed drug. REV-EYES (dapiprazole hydrochloride ophthalmic solution), 0.5%, is the...

  3. 75 FR 27840 - NUREG-0654/FEMA-REP-1, Rev. 1, Supplement 3, Guidance for Protective Action Recommendations for...

    Science.gov (United States)

    2010-05-18

    ...: 2010-11842] NUCLEAR REGULATORY COMMISSION [NRC-2010-0080] NUREG-0654/FEMA-REP-1, Rev. 1, Supplement 3...: ``NUREG-0654/FEMA-REP-1, Rev. 1, Supplement 3, Guidance for Protective Action Recommendations for General... the existing guidance contained in Supplement 3 to NUREG- 0654/FEMA-REP-1, Rev. 1, ``Criteria...

  4. 75 FR 10524 - NUREG-0654/FEMA-REP-1, Rev. 1, Supplement 3, Guidance for Protective Action Recommendations for...

    Science.gov (United States)

    2010-03-08

    ... COMMISSION NUREG-0654/FEMA-REP-1, Rev. 1, Supplement 3, Guidance for Protective Action Recommendations for... document entitled: ``NUREG-0654/FEMA-REP-1, Rev. 1, Supplement 3, Guidance for Protective Action...-4737, or by e-mail to pdr.resource@nrc.gov . NUREG-0654/FEMA-REP-1, Rev. 1, Supplement 3,...

  5. Multi-Faceted Post-Transcriptional Functions of HIV-1 Rev

    Directory of Open Access Journals (Sweden)

    Kuan-Teh Jeang

    2012-07-01

    Full Text Available Post-transcriptional regulation of HIV-1 gene expression is largely governed by the activities of the viral Rev protein. In this minireview, the multiple post-transcriptional activities of Rev in the export of partially spliced and unspliced HIV-1 RNAs from the nucleus to the cytoplasm, in the translation of HIV-1 transcripts, and in the packaging of viral genomic RNAs are reviewed in brief.

  6. Offshore wind farms in the local environment - an examination at Horns Rev Offshore Wind Farm. Background report; Havvindmoeller i lokalomraadet - en undersoegelse ved Horns Rev Havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, Susanne

    2005-07-01

    Horns Rev Offshore Wind Farm was built in 2002. A presentation is made of a sociological, qualitative survey on the local community's reception of the offshore wind farm. The survey aims at identifying attitudes towards the farm before and after the construction, with a view to identifying possible changes in attitudes, and explain the reasons for these (ml)

  7. Application of RevPASH index in restaurant management%RevPASH指标在餐饮管理中的应用

    Institute of Scientific and Technical Information of China (English)

    王琪

    2013-01-01

    随着社会经济水平的提高,我国的餐饮业发展非常迅速。餐饮业和其他企业一样,也需要做好管理,而RevPASH指标作为一种重要的管理方法已在餐饮业得到了广泛的应用。文章主要对RevPASH指标在餐饮管理中的应用做了探讨。%With the improvement of socio-economic level, catering industry in our country is developing very quickly. The catering industry and other enterprises, also need to do a good job in the management, and take RevPASH index as an important management method, has been widely used in the food and beverage industry. This paper explored the application of RevPASH index in restaurant management.

  8. EDs trying not to let the bed bugs bite.

    Science.gov (United States)

    2010-09-01

    As bed bugs have emerged as a growing problem for EDs, managers have developed strategies for prevention and decontamination. Here are some of the approaches they have shared with ED Management: Educate your staff on what they should look for on patients and in rooms that would indicate the presence of bed bugs. Be proactive. Have an exterminator examine your ED on a regular basis. A decontamination room on the outside of the building will prevent the spread of these bugs in your ED.

  9. Unperturbed posttranscriptional regulatory Rev protein function and HIV-1 replication in astrocytes.

    Directory of Open Access Journals (Sweden)

    Ashok Chauhan

    Full Text Available Astrocytes protect neurons, but also evoke proinflammatory responses to injury and viral infections, including HIV. There is a prevailing notion that HIV-1 Rev protein function in astrocytes is perturbed, leading to restricted viral replication. In earlier studies, our finding of restricted viral entry into astrocytes led us to investigate whether there are any intracellular restrictions, including crippled Rev function, in astrocytes. Despite barely detectable levels of DDX3 (Rev-supporting RNA helicase and TRBP (anti-PKR in primary astrocytes compared to astrocytic cells, Rev function was unperturbed in wild-type, but not DDX3-ablated astrocytes. As in permissive cells, after HIV-1 entry bypass in astrocytes, viral-encoded Tat and Rev proteins had robust regulatory activities, leading to efficient viral replication. Productive HIV-1 infection in astrocytes persisted for several weeks. Our findings on HIV-1 entry bypass in astrocytes demonstrated that the intracellular environment is conducive to viral replication and that Tat and Rev functions are unperturbed.

  10. Minor injury attendance times to the ED.

    LENUS (Irish Health Repository)

    Conlon, Ciaran

    2009-07-01

    The Health Service Executive (HSE) highlights the need for effective patient throughput and management, whilst providing appropriate staffing and therapeutic interventions. It acknowledges that patient need is integral to the development of a nurse led service and advocates planning staffing levels to reflect arrival times of patients. An observational study of all patients who presented to the emergency department in July 2005 and February 2006 was undertaken (n=7768). The study identified 1577 patients suitable for treatment by the Advanced Nurse Practitioner (ANP) in these two months, which represents 20% of all patient attendances to the ED in this time period. A data collection tool was devised collectively by the ANPs to identify appropriate patients. The findings of the study revealed that 73% of patients suitable for the ANP service presented between the hours of 0800 and 2000, of which 54% attended between 0800 and 1600 h. Sunday emerged as the busiest day in July 2005 whereas Monday was found to be the busiest day in February 2006. Friday was found to be consistently busy for both months.

  11. Direct and Indirect Suppression of Interleukin-6 Gene Expression in Murine Macrophages by Nuclear Orphan Receptor REV-ERBα

    Directory of Open Access Journals (Sweden)

    Shogo Sato

    2014-01-01

    Full Text Available It is now evident that many nuclear hormone receptors can modulate target gene expression. REV-ERBα, one of the nuclear hormone receptors with the capacity to alter clock function, is critically involved in lipid metabolism, adipogenesis, and the inflammatory response. Recent studies suggest that REV-ERBα plays a key role in the mediation between clockwork and inflammation. The purpose of the current study was to investigate the role of REV-ERBα in the regulation of interleukin-6 (il6 gene expression in murine macrophages. REV-ERBα agonists, or overexpression of rev-erbα in the murine macrophage cell line RAW264 cells, suppressed the induction of il6 mRNA following a lipopolysaccharide (LPS endotoxin challenge. Also, rev-erbα overexpression decreased LPS-stimulated nuclear factor κB (NFκB activation in RAW264 cells. We showed that REV-ERBα represses il6 expression not only indirectly through an NFκB binding motif but also directly through a REV-ERBα binding motif in the murine il6 promoter region. Furthermore, peritoneal macrophages from mice lacking rev-erbα increased il6 mRNA expression. These data suggest that REV-ERBα regulates the inflammatory response of macrophages through the suppression of il6 expression. REV-ERBα may therefore be identified as a potent anti-inflammatory receptor and be a therapeutic target receptor of inflammatory diseases.

  12. Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking.

    Directory of Open Access Journals (Sweden)

    Min-Hsuan Lin

    Full Text Available Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. Here we investigate the mechanism of this effect for the first time, establishing that redistribution of Rev by Nullbasic is not due to direct interaction between the two proteins. Rather, Nullbasic affects subcellular localization of cellular proteins that regulate Rev trafficking. In particular, Nullbasic induced redistribution of exportin 1 (CRM1, nucleophosmin (B23 and nucleolin (C23 from the nucleolus to the nucleus when Rev was coexpressed, but never in its absence. Inhibition of the Rev:CRM1 interaction by leptomycin B or a non-interacting RevM10 mutant completely blocked redistribution of Rev by Nullbasic. Finally, Nullbasic did not inhibit importin β- or transportin 1-mediated nuclear import, suggesting that cytoplasmic accumulation of Rev was due to increased export by CRM1. Overall, our data support the conclusion that CRM1-dependent subcellular redistribution of Rev from the nucleolus by Nullbasic is not through general perturbation of either nuclear import or export. Rather, Nullbasic appears to interact with and disrupt specific components of a Rev trafficking complex required for its nucleocytoplasmic shuttling and, in particular, its nucleolar accumulation.

  13. Measuring the Fidelity of Re-ED Programs.

    Science.gov (United States)

    Meadowcroft, Pamela; Cantrell, Mary Lynn; Cantrell, Robert P.

    2002-01-01

    The effectiveness of a comprehensive intervention like Re-ED (Reeducation of Emotional Disturbed Children) requires a clear definition of the essential components of the model. This article describes an ongoing process to create a program assessment tool for Re-ED. Program fidelity requires being able to specify precisely what is meant by certain…

  14. Teaching Elementary School Social Studies Methods under edTPA

    Science.gov (United States)

    An, Sohyun

    2016-01-01

    This article reports a self-study that analyzes my experience as a teacher educator navigating a turbulent educational landscape with the advent of edTPA. The data consist of my journal entries, the syllabi, handouts, work submitted by my students, and course evaluations. Data were analyzed by using an inductive process to describe how the edTPA…

  15. Effects of EdU labeling on mesenchymal stem cells

    OpenAIRE

    Ning, Hongxiu; Albersen, Maarten; Lin, Guiting; Lue, Tom F.; Lin, Ching-Shwun

    2013-01-01

    Thymidine analog 5-ethynyl-2-deoxyuridine (EdU) has recently been used for tracking mesenchymal stem cells (MSCs). In the present study, we tested whether EdU was cytotoxic and whether it interfered with differentiation, cytokine secretion and migration of MSCs.

  16. Impact of REV-ERB alpha gene polymorphisms on obesity phenotypes in adult and adolescent samples.

    Science.gov (United States)

    Goumidi, L; Grechez, A; Dumont, J; Cottel, D; Kafatos, A; Moreno, L A; Molnar, D; Moschonis, G; Gottrand, F; Huybrechts, I; Dallongeville, J; Amouyel, P; Delaunay, F; Meirhaeghe, A

    2013-05-01

    REV-ERBα has been shown to regulate adipogenesis and lipid metabolism as well as to link the circadian timing system to whole body metabolic homeostasis. We thus tested whether polymorphisms in REV-ERBα could be associated with metabolic phenotypes in human population samples. We analyzed the associations between 5 REV-ERBα polymorphisms and anthropometric (body weight, body mass index (BMI), waist and hip circumferences), biochemical (plasma lipid, glucose and insulin levels) and clinical (systolic and diastolic blood pressure) variables in three population-based studies (MONICA Lille n=1155 adults, MONA LISA Lille n=1170 adults and HELENA n=1155 adolescents). We assessed in vitro, the potential influence of one REV-ERBα polymorphism in transient transfection assays using two different cell lines. We observed significant and consistent associations between the T minor allele of the REV-ERBα rs2071427 polymorphism (located in intron 1) and higher BMI (mean allele effect=+0.33 kg m(-2)) in the MONICA Lille (P=0.02), MONA LISA (P=0.02) and HELENA (P=0.03) studies. The odds ratios for obesity associated with this allele were 1.67 (1.00-2.79) (P=0.05) in MONICA Lille, 1.29 (1.01-1.65) (P=0.04) in MONA LISA Lille and the odds ratio for overweight was 1.48 (1.08-2.03) (P=0.01) in HELENA. In transfection experiments in human hepatocyte-derived cell lines, the REV-ERBα intron 1 directed the transcription of a luciferase reporter gene independently of the rs2071427 polymorphism. Our results suggest that the REV-ERBα rs2071427 polymorphism modulates body fat mass in both adult and young people.

  17. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

    Directory of Open Access Journals (Sweden)

    Gwendal Le Martelot

    2009-09-01

    Full Text Available In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coordinated by the circadian timing system. Molecular clocks are thought to rely on negative feedback loops in clock gene expression that engender oscillations in the accumulation of transcriptional regulatory proteins, such as the orphan receptor REV-ERBalpha. Circadian transcription factors then drive daily rhythms in the expression of clock-controlled output genes, for example genes encoding enzymes and regulators of cellular metabolism. To gain insight into clock output functions of REV-ERBalpha, we carried out genome-wide transcriptome profiling experiments with liver RNA from wild-type mice, Rev-erbalpha knock-out mice, or REV-ERBalpha overexpressing mice. On the basis of these genetic loss- and gain-of-function experiments, we concluded that REV-ERBalpha participates in the circadian modulation of sterol regulatory element-binding protein (SREBP activity, and thereby in the daily expression of SREBP target genes involved in cholesterol and lipid metabolism. This control is exerted via the cyclic transcription of Insig2, encoding a trans-membrane protein that sequesters SREBP proteins to the endoplasmic reticulum membranes and thereby interferes with the proteolytic activation of SREBPs in Golgi membranes. REV-ERBalpha also participates in the cyclic expression of cholesterol-7alpha-hydroxylase (CYP7A1, the rate-limiting enzyme in converting cholesterol to bile acids. Our findings suggest that this control acts via the stimulation of LXR nuclear receptors by cyclically produced oxysterols. In conclusion, our study suggests that rhythmic cholesterol and bile acid metabolism is not just driven by alternating feeding-fasting cycles, but also by REV-ERBalpha, a component of the circadian clockwork circuitry.

  18. Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function

    Directory of Open Access Journals (Sweden)

    St-Laurent Georges

    2006-11-01

    Full Text Available Abstract Background The HIV Rev protein is known to facilitate export of incompletely spliced and unspliced viral transcripts to the cytoplasm, a necessary step in virus life cycle. The Rev-mediated nucleo-cytoplasmic transport of nascent viral transcripts, dependents on interaction of Rev with the RRE RNA structural element present in the target RNAs. The C-terminal variant of dsRNA-binding nuclear protein 90 (NF90ctv has been shown to markedly attenuate viral replication in stably transduced HIV-1 target cell line. Here we examined a mechanism of interference of viral life cycle involving Rev-NF90ctv interaction. Results Since Rev:RRE complex formations depend on protein:RNA and protein:protein interactions, we investigated whether the expression of NF90ctv might interfere with Rev-mediated export of RRE-containing transcripts. When HeLa cells expressed both NF90ctv and Rev protein, we observed that NF90ctv inhibited the Rev-mediated RNA transport. In particular, three regions of NF90ctv protein are involved in blocking Rev function. Moreover, interaction of NF90ctv with the RRE RNA resulted in the expression of a reporter protein coding sequences linked to the RRE structure. Moreover, Rev influenced the subcellular localization of NF90ctv, and this process is leptomycin B sensitive. Conclusion The dsRNA binding protein, NF90ctv competes with HIV Rev function at two levels, by competitive protein:protein interaction involving Rev binding to specific domains of NF90ctv, as well as by its binding to the RRE-RNA structure. Our results are consistent with a model of Rev-mediated HIV-1 RNA export that envisions Rev-multimerization, a process interrupted by NF90ctv.

  19. TechEdSat Nano-Satellite Series Fact Sheet

    Science.gov (United States)

    Murbach, Marcus; Martinez, Andres; Guarneros Luna, Ali

    2014-01-01

    TechEdSat-3p is the second generation in the TechEdSat-X series. The TechEdSat Series uses the CubeSat standards established by the California Polytechnic State University Cal Poly), San Luis Obispo. With typical blocks being constructed from 1-unit (1U 10x10x10 cm) increments, the TechEdSat-3p has a 3U volume with a 30 cm length. The project uniquely pairs advanced university students with NASA researchers in a rapid design-to-flight experience lasting 1-2 semesters.The TechEdSat Nano-Satellite Series provides a rapid platform for testing technologies for future NASA Earth and planetary missions, as well as providing students with an early exposure to flight hardware development and management.

  20. The full moon and ED patient volumes: unearthing a myth.

    Science.gov (United States)

    Thompson, D A; Adams, S L

    1996-03-01

    To determine if there is any effect of the full moon on emergency department (ED) patient volume, ambulance runs, admissions, or admissions to a monitored unit, a retrospective analysis of the hospital electronic records of all patients seen in an ED during a 4-year period was conducted in an ED of a suburban community hospital. A full moon occurred 49 times during the study period. There were 150,999 patient visits to the ED during the study period, of which 34,649 patients arrived by ambulance. A total of 35,087 patients was admitted to the hospital and 11,278 patients were admitted to a monitored unit. No significant differences were found in total patient visits, ambulance runs, admissions to the hospital, or admissions to a monitored unit on days of the full moon. The occurrence of a full moon has no effect on ED patient volume, ambulance runs, admissions, or admissions to a monitored unit.

  1. Deconstructing Stereotypes : Ed Bullins' the Taking of Miss Janie = Ed Bullins'in

    Directory of Open Access Journals (Sweden)

    Çiğdem Pala MULL

    2004-06-01

    Full Text Available African-American playwright Ed Bullins is one of the most significant figures to emerge from the Black Arts Movement of the 1960s. His 1975 play The Taking of Miss Janie is a dramatic portrait of the specific events and ideas that created the 1960s, and their impact on the individual consciousnesses of the characters. The play brings into the foreground many issues related to race and ethnicity in America. Even though the general tone of The Taking of Miss Janie is one of violence and gloom, this reading focuses on those moments where love and human affection outshine the sense of destruction predominant in the play.

  2. cdma2000 1x EV-DO Rev.A的多流分组应用%MFPA of cdma2000 1x EV-DO Rev.A

    Institute of Scientific and Technical Information of China (English)

    摩托罗拉公司

    2007-01-01

    cdma2000 1x EV-DO版本A(即release A)将是中国CDMA运营商的3G选择.为使用户能同时支持不同QoS的实时应用,EV-DO Rev.A的数据平面引入了多流分组应用.为配合MFPA的应用,分组数据业务节点(PDSN)亦须做相应的升级.

  3. Empirical investigation of wind farm blockage effects in Horn Rev 1 offshore wind farm

    DEFF Research Database (Denmark)

    Mitraszewski, Karol; Hansen, Kurt Schaldemose; Nygaard, Nicolai;

    We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds and stabi......We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds...

  4. Administrative Circular No. 13 (Rev. 4) - Guarantees for representatives of the personnel

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 13 (Rev. 4) entitled "Guarantees for representatives of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208527.   This revised circular cancels and replaces Administrative Circular No. 13 (Rev. 3) also entitled "Guarantees for representatives of the personnel" of January 2014. This document contains a single change to reflect the terminology under the new career structure: the term "career path" is replaced by "grade". This circular will enter into force on 1st September 2016.

  5. Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia.

    Science.gov (United States)

    Tamura, Satoru; Kaneko, Masafumi; Shiomi, Atsushi; Yang, Guang-Ming; Yamaura, Toshiaki; Murakami, Nobutoshi

    2010-03-15

    Bioassay-guided separation from the MeOH extract of the South American medicinal plant Sida cordifolia resulted in isolation of (10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (1) as an unprecedented NES non-antagonistic inhibitor for nuclear export of Rev. This mechanism of action was established by competitive experiment by the biotinylated probe derived from leptomycin B, the known NES antagonistic inhibitor. Additionally, structure-activity relationship analysis by use of the synthesized analogs clarified cooperation of several functionalities in the Rev-export inhibitory activity of 1. Copyright 2010 Elsevier Ltd. All rights reserved.

  6. Switching studies for the Horns Rev 2 wind farm main cable

    DEFF Research Database (Denmark)

    Jensen, Christian Flytkjær; Faria da Silva, Filipe; Bak, Claus Leth

    2011-01-01

    This article proposes a method of constructing a PSCAD model suitable for switching studies in a system containing long HVAC cables. The transmission network connection to the 215 MW offshore wind farm Horns Rev 2 is used as a case study. The connection to Horns Rev 2 consists of two land cable...... model used in PSCAD are given. Results obtained using the model are compared to full scale measurement of the energization of the system, and good agreement is found. The influence of different simulation parameters are examined; amongst them the modeling of the screen, the relative permittivity...

  7. Rev-erbα and the circadian transcriptional regulation of metabolism

    DEFF Research Database (Denmark)

    Gerhart-Hines, Z.; Lazar, M. A.

    2015-01-01

    The circadian clock orchestrates the coordinated rhythmicity of numerous metabolic pathways to anticipate daily and seasonal changes in energy demand. This vital physiol. function is controlled by a set of individual clock components that are present in each cell of the body, and regulate each...... other as well as clock output genes. A key factor is the nuclear receptor, Rev-erbα, a transcriptional repressor which functions not only as a clock component but also as a modulator of metabolic programming in an array of tissues. This review explores the role of Rev-erbα in mediating this crosstalk...

  8. Administrative Circular No. 11 (Rev. 4) - Categories of members of the personnel

    CERN Multimedia

    HR Department

    2016-01-01

    Administrative Circular No. 11 (Rev. 4) entitled "Categories of members of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 29 April 2016, will be available on 1 August 2016 via this following link.    This revised circular cancels and replaces the Administrative Circular No. 11 (Rev. 3) also entitled "Categories of members of the personnel" of September 2014. The main changes concern the status of apprentices and their transfer from the category of employed members of personnel to associated members of personnel. This circular will enter into force on 1 August 2016. Department Head Office

  9. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P. [NERI, Dept. of Wildlife Ecology and Biodiversity, Roskilde (Denmark)

    2005-07-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  10. Administrative Circular No. 22B (Rev. 2) - Compensation for hours of long-term shift work

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 22B (Rev. 2) entitled "Compensation for hours of long-term shift work",  approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208538.   This revised circular cancels and replaces Administrative Circular No. 22B (Rev. 1) also entitled "Compensation for hours of long-term shift work" of March 2011. This document contains minor changes to reflect the new career structure. This circular will enter into force on 1st September 2016.

  11. Effect of Modified Atmosphere Packaging on Microbiological ...

    African Journals Online (AJOL)

    phrases: Modified atmosphere packaging, polypropylene, low density polyethylene ..... data from two packs pre treatment; mean separation by Duncan's Multiple Range Test at value 1%. ..... communities of lrltltiopia. ltlast Africa Medical. Journal ...

  12. A distance regular graph of type E1 Ed

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    In this note, the distance regular graph of type E1 Ed is considered and some characterization of the type graph is given. The results generalize the characterization of tight distance regular graphs.

  13. Elementi ed esercizi di geometria analitica e proiettiva

    CERN Document Server

    Francia, Giovanni

    1950-01-01

    La retta : preliminario ; coordinate cartesiane nel piano, equazioni della retta, distanze ed angoli ; cambiamento delle coordinate, coordinate polari ; il cerchio ; le coniche come luoghi geometrici : l'ellisse, l'iperbole, parabola.

  14. Nuclear Medicine Physics: The Basics. 7th ed.

    Science.gov (United States)

    Mihailidis, Dimitris

    2012-10-01

    Nuclear Medicine Physics: The Basics. 7th ed. Ramesh Chandra, Lippincott Williams and Wilkins, a Wolters Kluwer Business. Philadelphia, 2012. Softbound, 224 pp. Price: $69.99. ISBN: 9781451109412. © 2012 American Association of Physicists in Medicine.

  15. Safe Handling of Snakes in an ED Setting.

    Science.gov (United States)

    Cockrell, Melanie; Swanson, Kristofer; Sanders, April; Prater, Samuel; von Wenckstern, Toni; Mick, JoAnn

    2017-01-01

    Efforts to improve consistency in management of snakes and venomous snake bites in the emergency department (ED) can improve patient and staff safety and outcomes, as well as improve surveillance data accuracy. The emergency department at a large academic medical center identified an opportunity to implement a standardized process for snake disposal and identification to reduce staff risk exposure to snake venom from snakes patients brought with them to the ED.

  16. DISTRIBUZIONE, TASSONOMIA ED IMPATTO ECOLOGICO DI SPECIE ALIENE

    OpenAIRE

    Stinca, Adriano

    2013-01-01

    Il problema delle specie aliene, soprattutto negli ultimi decenni, è diventato un elemento cruciale nella biologia della conservazione. La diffusione rapida ed incontrollata di organismi estranei al contesto territoriale di riferimento, infatti, spesso comporta impatti sulla biodiversità e sul funzionamento degli ecosistemi. In tali casi, pertanto, vi è anche l’incapacità da parte degli stessi sistemi biologici invasi a ristabilire autonomamente ed in tempi relativamente brevi le condizioni i...

  17. Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function.

    Science.gov (United States)

    Yedavalli, Venkat S R K; Neuveut, Christine; Chi, Ya-Hui; Kleiman, Lawrence; Jeang, Kuan-Teh

    2004-10-29

    A single transcript in its unspliced and spliced forms directs the synthesis of all HIV-1 proteins. Although nuclear export of intron-containing cellular transcripts is restricted in mammalian cells, HIV-1 has evolved the viral Rev protein to overcome this restriction for viral transcripts. Previously, CRM1 was identified as a cellular cofactor for Rev-dependent export of intron-containing HIV-1 RNA. Here, we present evidence that Rev/CRM1 activity utilizes the ATP-dependent DEAD box RNA helicase, DDX3. We show that DDX3 is a nucleo-cytoplasmic shuttling protein, which binds CRM1 and localizes to nuclear membrane pores. Knockdown of DDX3 using either antisense vector or dominant-negative mutants suppressed Rev-RRE-function in the export of incompletely spliced HIV-1 RNAs. Plausibly, DDX3 is the human RNA helicase which functions in the CRM1 RNA export pathway analogously to the postulated role for Dbp5p in yeast mRNA export.

  18. Horns Rev 2 offshore wind farm photo case with wakes observed in 2016

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Nygaard, Nicolai Gayle; Volker, Patrick

    Offshore wind farm wakes were photographed in foggy conditions at Horns Rev 2 on 25 January 2016 at 12:45 UTC (See1). The study examines the atmospheric conditions from satellite images, radiosonde, vertical profiling wind lidar located at the transformer platform and SCADA data. Furthermore...

  19. Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates

    NARCIS (Netherlands)

    E. Sonoda (Eiichiro); S. Takeda (Shiunichi); T. Okada (Takashi); G.Y. Zhao (Guang); S. Tateishi (Satoshi); K. Araki (Kasumi); M. Yamaizumi (Masaru); T. Yagi (Takashi); N.S. Verkaik (Nicole); D.C. van Gent (Dik); M. Takata (Minoru)

    2003-01-01

    textabstractTranslesion DNA synthesis (TLS) and homologous DNA recombination (HR) are two major postreplicational repair (PRR) pathways. The REV3 gene of Saccharomyces cerevisiae encodes the catalytic subunit of DNA polymerase zeta, which is involved in mutagenic TLS. To investigat

  20. Power deficits due to wind turbine wakes at Horns Rev wind farm

    DEFF Research Database (Denmark)

    Hansen, Kurt Schaldemose; Barthelmie, Rebecca; Jensen, Leo E.

    2010-01-01

    The wind turbine operational charac-teristics, power measurements and the meteorological measurements as 10 minute statistical data from Horns Rev offshore wind farm have been identified, synchronized, quality screened and stored in a common database. A number of flow cases have been identified...

  1. TextRev: A Window into How General and Organic Chemistry Students Use Textbook Resources.

    Science.gov (United States)

    Smith, Bradley D.; Jacobs, Dennis C.

    2003-01-01

    Points out the important use of textbooks and their ancillary resources in lower-division chemistry courses and the scientific misconceptions found in them. Introduces the TextRev Project which is a new resource for data collection and analysis. Investigates how first and second year chemistry students use and value their textbooks and their study…

  2. Regulation of bile acid synthesis by the nuclear receptor Rev-erb alpha

    NARCIS (Netherlands)

    Duez, Helene; Van Der Veen, Jelske N.; Duhem, Christian; Pourcet, Benoit; Touvier, Thierry; Fontaine, Coralie; Derudas, Bruno; Bauge, Eric; Havinga, Rick; Bloks, Vincent W.; Wolters, Henk; Van Der Sluijs, Fjodor H.; Vennstrom, Bjorn; Kuipers, Folkert; Staels, Bart

    2008-01-01

    Background & Aims: Conversion into bile acids represents an important route to remove excess cholesterol from the body. Rev-erb alpha is a nuclear receptor that participates as one of the clock genes in the control of circadian rhythmicity and plays a regulatory role in lipid metabolism and adipogen

  3. Determining the REV for Fracture Rock Mass Based on Seepage Theory

    Directory of Open Access Journals (Sweden)

    Lili Zhang

    2017-01-01

    Full Text Available Seepage problems of the fractured rock mass have always been a heated topic within hydrogeology and engineering geology. The equivalent porous medium model method is the main method in the study of the seepage of the fractured rock mass and its engineering application. The key to the method is to determine a representative elementary volume (REV. The FractureToKarst software, that is, discrete element software, is a main analysis tool in this paper and developed by a number of authors. According to the standard of rock classification established by ISRM, this paper aims to discuss the existence and the size of REV of fractured rock masses with medium tractility and provide a general method to determine the existence of REV. It can be gleaned from the study that the existence condition of fractured rock mass with medium tractility features average fracture spacing smaller than 0.6 m. If average fracture spacing is larger than 0.6 m, there is no existence of REV. The rationality of the model is verified by a case study. The present research provides a method for the simulation of seepage field in fissured rocks.

  4. Offshore wind farms in the local community - a survey at Horns Rev wind farm. Background report; Havvindmoeller i lokalomraedet - en undersoegelse ved Horns Rev havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, S.

    2005-07-15

    This report is part of a socio-economic project about offshore wind farms' influence on the local community. The project is part of the monitoring programme in connection with the establishment of the offshore wind farms at Horns Rev and Nysted. The socio-economic project consists of a sociological and an environment-economic project. This report is part of the sociological project which has the purpose of identifying attitudes towards the wind farm before and after the erection with a view to identify possible changes in opinions and reasons for these changes. (BA)

  5. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2004-05-15

    Elsam and Eltra built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm off the Danish west coast. The wind farm is sited 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine was erected in May 2002 and the last wind turbine tower of a total of 80 was in place by August 2002. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production by December 2002. The expected impact of the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind turbine towers and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horns Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site-specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrate was conducted in March 2003 and in September 2003. This report describes the first year results of surveys on hard substrate after the completion of the offshore wind farm at Horns Rev. (au)

  6. Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration.

    Directory of Open Access Journals (Sweden)

    Aviad Levin

    Full Text Available BACKGROUND: The human immunodeficiency virus type 1 (HIV-1 integrase protein (IN, catalyzes the integration of viral DNA into the host cell genome. IN catalyzes the first step of the integration process, namely the 3'-end processing in which IN removes a pGT dinucleotide from the 3' end of each viral long terminal repeat (LTR. Following nuclear import of the viral preintegration complex, the host chromosomal DNA becomes accessible to the viral cDNA and the second step of the integration process, namely the strand-transfer step takes place. This ordered sequence of events, centered on integration, is mandatory for HIV replication. METHODOLOGY/PRINCIPAL FINDINGS: Using an integrase peptide library, we selected two peptides, designated INr-1 and INr-2, which interact with the Rev protein and probably mediate the Rev-integrase interaction. Using an in-vitro assay system, we show that INr-1 and INr-2 are able to abrogate the inhibitory effects exerted by Rev and Rev-derived peptides on integrase activity. Both INr-1 and INr-2 were found to be cell-permeable and nontoxic, allowing a study of their effect in HIV-1-infected cultured cells. Interestingly, both INr peptides stimulated virus infectivity as estimated by production of the viral P24 protein, as well as by determination of the appearance of newly formed virus particles. Furthermore, kinetics studies revealed that the cell-permeable INr peptides enhance the integration process, as was indeed confirmed by direct determination of viral DNA integration by real-time PCR. CONCLUSIONS/SIGNIFICANCE: The results of the present study raise the possibility that in HIV-infected cells, the Rev protein may be involved in the integration of proviral DNA by controlling/regulating the activity of the integrase. Release from such inhibition leads to stimulation of IN activity and multiple viral DNA integration events.

  7. Lasers (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Hellman, Hal

    1969-01-01

    A laser is an instrument that produces an enormously intense pencil-thin beam of light. In this booklet we shall learn what there is about the laser that gives it so much promise. We shall investigate what it is, how it works, and the different kinds of lasers there are.

  8. Computers (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R

    1967-01-01

    This booklet relates how wires, transistors, and human ingenuity are combined to produce machines that surpass all the calculating prodigies that ever lived in speed, accuracy, and stamina, though perhaps not in the matter of mystery.

  9. Computers (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R

    1967-01-01

    This booklet relates how wires, transistors, and human ingenuity are combined to produce machines that surpass all the calculating prodigies that ever lived in speed, accuracy, and stamina, though perhaps not in the matter of mystery.

  10. A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: characterization of the paratope.

    Science.gov (United States)

    Zhuang, Xiaolei; Stahl, Stephen J; Watts, Norman R; DiMattia, Michael A; Steven, Alasdair C; Wingfield, Paul T

    2014-07-18

    The HIV-1 protein Rev oligomerizes on viral transcripts and directs their nuclear export. Previously, a Fab against Rev generated by phage display was used to crystallize and solve the structure of the Rev oligomerization domain. Here we have investigated the capability of this Fab to block Rev oligomerization and inhibit HIV-1 replication. The Fab itself did not have antiviral activity, but when a Tat-derived cell-penetrating peptide was appended, the resulting molecule (FabRev1-Tat) was strongly inhibitory of three different CCR5-tropic HIV-1 isolates (IC50 = 0.09-0.44 μg/ml), as assessed by suppression of reverse transcriptase activity in infected peripheral blood mononuclear cells, and had low cell toxicity (TC50 > 100 μg/ml). FabRev1-Tat was taken up by both peripheral blood mononuclear and HEK293T cells, appearing in both the cytoplasm and nucleus, as shown by immunofluorescence confocal laser scanning microscopy. Computational alanine scanning was used to identify key residues in the complementarity-determining regions to guide mutagenesis experiments. Residues in the light chain CDR3 (LCDR3) were assessed to be important. Residues in LCDR3 were mutated, and LCDR3-Tyr(92) was found to be critical for binding to Rev, as judged by surface plasmon resonance and electron microscopy. Peptides corresponding to all six CDR regions were synthesized and tested for Rev binding. None of the linear peptides had significant affinity for Rev, but four of the amide-cyclic forms did. Especially cyclic-LCDR3 (LGGYPAASYRTA) had high affinity for Rev and was able to effectively depolymerize Rev filaments, as shown by both surface plasmon resonance and electron microscopy.

  11. MANY MEN USED ED TREATMENT WITHOUT THEIR PARTNERS’ KNOWLEDGE

    Directory of Open Access Journals (Sweden)

    Tan HM

    2007-01-01

    Full Text Available This paper aimed to identify and explore the understanding and perception of erectile dysfunction (ED using exploratory qualitative approaches. This study was conducted in Klang Valley, Malaysia. Purposive sampling was used to recruit 17 urban men aged 40-75 years. A semi-structural interview guide was used to explore men’s understanding of ED, impacts on their well-being and experiences with treatments. The focus groups revealed that ED was perceived to be an important loss in men’s lives as sexual performance was closely related to manhood. The men associated ED with a loss of masculinity and self-esteem. Men’s understanding of ED treatments was restricted to phophodiesterase type 5 inhibitors (PDE-5 inhibitors and traditional therapies. Although PDE-5 inhibitors were perceived to be effective, they were concerned about their safety and costs. Some of the men have learned to cope with ED rather than to seek help, particularly among older men, who attributed their decreased sexual capacities and erection difficulties to aging, and therefore conditioned themselves to accepting it. In contrast, younger men who have erectile difficulties are considered as ‘abnormal’, and are more likely to seek help and receive treatment for their sexual problem. Men’s knowledge of and experience with modern treatments of ED were mainly associated with PDE-5 inhibitors. Their perception towards PDE-5 inhibitors was largely influenced by personal experience, information from mass media and friends. The high cost and fear of side effects were two main deterrents in the use of PDE-5 inhibitors. Many men had conceded their use of PDE-5 inhibitors without their partners’ knowledge. They worried that their partners would view the matter with suspicion and mistrust.

  12. 75 FR 32493 - NUREG-0654/FEMA-REP-, Rev. 1, Supplement 3, Guidance for Protective Action Recommendations for...

    Science.gov (United States)

    2010-06-08

    ... SECURITY Federal Emergency Management Agency NUREG-0654/FEMA-REP-, Rev. 1, Supplement 3, Guidance for... be held to discuss the proposed Supplement 3 to NUREG-0654/FEMA-REP-1, Rev.1, Guidance for Protective Action Recommendations for General Emergencies (NUREG Supp 3). NUREG Supp 3 addresses onsite and...

  13. 48 CFR 53.301-1415 - SF 1415 (Rev. 7/93) Consent of Surety and Increase of Penalty.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 1415 (Rev. 7/93) Consent of Surety and Increase of Penalty. 53.301-1415 Section 53.301-1415 Federal Acquisition Regulations...-1415 SF 1415 (Rev. 7/93) Consent of Surety and Increase of Penalty. EC01MY91.102...

  14. 78 FR 63964 - Request for Comments on Draft NIST Interagency Report (NISTIR) 7628 Rev. 1, Guidelines for Smart...

    Science.gov (United States)

    2013-10-25

    ... (NISTIR) 7628 Rev. 1, Guidelines for Smart Grid Cyber Security AGENCY: National Institute of Standards and... Smart Grid Cyber Security. Draft NISTIR 7628 Rev. 1 was completed by the NIST-led Smart Grid Cybersecurity Committee (formerly the Cyber Security Working Group) of the Smart Grid Interoperability...

  15. Chick embryo proliferation studies using EdU labeling.

    Science.gov (United States)

    Warren, Michelle; Puskarczyk, Karolina; Chapman, Susan C

    2009-04-01

    Cell proliferation studies are an important experimental tool. The most commonly used thymidine analogues, tritiated thymidine and bromodeoxyuridine (BrdU) label cells during S-phase. Both methods have significant drawbacks: low sensitivity in the case of tritiated thymidine and a denaturation step during BrdU detection that destroys most cellular epitopes, requiring careful optimization. The antibody against BrdU is also large and tissue penetration can be difficult. EdU (5'-ethynyl-2'-deoxyuridine) is closely chemically related to BrdU, with detection achieved by a copper catalyzed reaction requiring a small fluorescently conjugated azide. Cell cultures, flow cytometry and high throughput studies using EdU-labeled cells is exceptionally fast and does not require denaturation or antibodies. We have developed a tissue-labeling technique in chick embryos using EdU. Following EdU chemistry to detect proliferating cells, the tissue can undergo immunolabeling. We demonstrate fluorescent EdU chemistry followed by Tuj1 antibody staining resulting in multiplex fluorescent tissues.

  16. Identification of Brucella melitensis Rev.1 vaccine-strain genetic markers: Towards understanding the molecular mechanism behind virulence attenuation.

    Science.gov (United States)

    Issa, Mohammad Nouh; Ashhab, Yaqoub

    2016-09-22

    Brucella melitensis Rev.1 is an avirulent strain that is widely used as a live vaccine to control brucellosis in small ruminants. Although an assembled draft version of Rev.1 genome has been available since 2009, this genome has not been investigated to characterize this important vaccine. In the present work, we used the draft genome of Rev.1 to perform a thorough genomic comparison and sequence analysis to identify and characterize the panel of its unique genetic markers. The draft genome of Rev.1 was compared with genome sequences of 36 different Brucella melitensis strains from the Brucella project of the Broad Institute of MIT and Harvard. The comparative analyses revealed 32 genetic alterations (30 SNPs, 1 single-bp insertion and 1 single-bp deletion) that are exclusively present in the Rev.1 genome. In silico analyses showed that 9 out of the 17 non-synonymous mutations are deleterious. Three ABC transporters are among the disrupted genes that can be linked to virulence attenuation. Out of the 32 mutations, 11 Rev.1 specific markers were selected to test their potential to discriminate Rev.1 using a bi-directional allele-specific PCR assay. Six markers were able to distinguish between Rev.1 and a set of control strains. We succeeded in identifying a panel of 32 genome-specific markers of the B. melitensis Rev.1 vaccine strain. Extensive in silico analysis showed that a considerable number of these mutations could severely affect the function of the associated genes. In addition, some of the discovered markers were able to discriminate Rev.1 strain from a group of control strains using practical PCR tests that can be applied in resource-limited settings.

  17. Reduction of electron channeling in EDS using precession.

    Science.gov (United States)

    Liao, Yifeng; Marks, Laurence D

    2013-03-01

    We demonstrated that EDS measurement can be significantly improved by precessing the electron beam, thereby reducing electron channeling effects. For a SrTiO3 specimen orientated along the [001] zone axis, the measured strontium to titanium atomic ratio was 0.74-0.80 using conventional EDS methods, and the ratio was improved to ~0.99 by precessing the electron beam for angles greater than 22.54 mRad. In ALCHEMI-like experiments in which the specimen was tilted to near two-beam condition, the strontium to titanium ratio was insensitive to the deviation from the Bragg condition using a precessed electron beam. Similar reduction of electron channeling effects was also observed in precession-assisted EDS measurements for an L21-ordered Fe2MnAl intermetallic alloy tilted to the [011] zone axis as well as near two-beam conditions.

  18. Administrative Cicular No. 31 (Rev. 2) - International indemnity and non-resident allowance

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 31 (Rev. 2) entitled "International indemnity and non-resident allowance", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 23 June 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208547.   This revised circular cancels and replaces Administrative Circular No. 31 (Rev. 1) also entitled "International indemnity and non-resident allowance" of October 2007. The main changes reflect the decision taken in the framework of the five-yearly review to extend eligibility for international indemnity to all staff members, as well to introduce a distinction between current staff members and those recruited as from 1st September 2016. For the latter, the international indemnity will be calculated as a percentage of the minimum salary of the grade into which they are recruited; the amount granted to the former will not change, and is now expressed ...

  19. The "effects" of Rev-1 vaccination of sheep and goats on human brucellosis in Greece.

    Science.gov (United States)

    Minas, A; Minas, M; Stournara, A; Tselepidis, S

    2004-06-10

    Vaccination of young animals (3-6-month-old sheep and goats) with Rev-1 vaccine for 15 years in Greece, importantly decreased the abortions in sheep and goats as well as the incidence of brucellosis in humans. After the stop of vaccination in 1994, all over Greece, the prevalence of brucellosis in animals and the incidence in humans quickly increased. It was a positive rank correlation (0.90) among these variables. Once an emergency mass-vaccination programme of young and adult animals with Rev-1 vaccine was started in 1998, the human incidence again decreased. The association of the vaccination coverage of animals and incidence of brucellosis in humans was not linear; the decrease in human brucellosis incidence was observed when the vaccination coverage of animals was >30%.

  20. Administrative Circular No. 11 (Rev. 3) - Categories of members of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 11 (Rev. 3) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 3 July 2014 and entering into force on 1 September 2014, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel” of January 2013. The circular was revised in order to include a minor adjustment of the determination of required period of break in the payment of subsistence allowance to certain categories of associated members of the personnel (taking account of possible technical means of control). Furthermore, the possibility of traineeships of long duration was restricted to cases in which the traineeship is awarded pursuant to an agreement between CERN and a...

  1. Administrative Circular No. 13 (Rev. 3) - Guarantees for representatives of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 13 (Rev. 3) entitled “Guarantees for representatives of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 13 (Rev. 2) entitled “Guarantees for members of the personnel holding representative office” of November 1992. The circular was revised in order to adapt the time given to the representatives of the personnel to perform their elective mandate and to ensure more transparency in their activities, by indicating, inter alia, the percentage of time worked in the framework of their mandate, as well as the training, activities and ensuing results. Department Head Office HR Department

  2. A Circular Motion Activity with Hot Wheels® Rev-Ups

    Science.gov (United States)

    Wagner, Glenn

    2009-02-01

    Hot Wheels® Rev-Ups provide a pedagogically engaging and inexpensive culminating activity for the application of circular motion with constant speed in introductory mechanics. The introductory Rev-Up, shown in Fig. 1, consists of a very durable car with two strong magnets built into the front and back of the car. The track is a piece of flexible plastic with a built-in metallic strip through its center that can then be formed into a circle. Pushing the car forward several times on a flat surface allows the car to move in a vertical circle when placed inside the track. What makes this toy attractive is that the gearing system allows the car to move at a relatively constant speed for about three to five seconds before slowing down appreciably.

  3. Portable Tester Friction (PFT). Mesures du coefficient de frottement dynamique de revêtements de sol

    OpenAIRE

    Marchal, P.; Jacques, M.

    2014-01-01

    Le Portable Tester Friction (PFT) est un appareil destiné à mesurer le coefficient de frottement dynamique d’un revêtement de sol en laboratoire et sur site. Ce document décrit le protocole de mesure avec le PFT et les résultats de mesures effectuées sur un panel de quinze revêtements de sol de caractéristiques différentes (matériaux, états de surface) réalisées en présence de deux polluants (huile et solution d’eau). Le PFT présente une très bonne sensibilité et une très bonne répétabilité. ...

  4. RevTrans: multiple alignment of coding DNA from aligned amino acid sequences

    DEFF Research Database (Denmark)

    Wernersson, Rasmus; Pedersen, Anders Gorm

    2003-01-01

    The simple fact that proteins are built from 20 amino acids while DNA only contains four different bases, means that the 'signal-to-noise ratio' in protein sequence alignments is much better than in alignments of DNA. Besides this information-theoretical advantage, protein alignments also benefit...... proteins. It is therefore preferable to align coding DNA at the amino acid level and it is for this purpose we have constructed the program RevTrans. RevTrans constructs a multiple DNA alignment by: (i) translating the DNA; (ii) aligning the resulting peptide sequences; and (iii) building a multiple DNA...... alignment by 'reverse translation' of the aligned protein sequences. In the resulting DNA alignment, gaps occur in groups of three corresponding to entire codons, and analogous codon positions are therefore always lined up. These features are useful when constructing multiple DNA alignments for phylogenetic...

  5. Administrative circular No. 20 (Rev. 2) – Use of private vehicules for journeys on official duty

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circular No. 20 (Rev. 2) entitled "Use of private vehicles for journeys on official duty", adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 January 2011, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 20 (Rev. 1) entitled "Use of private vehicles on official duty" of April 1993. This new version introduces, in particular, the payment of a kilometer allowance in case of emergency during standby duty or when on call and a simplified calculation of the allowance for journeys between sites. This circular also clarifies the type of permitted private vehicles. Department Head Office  

  6. Administrative circular n°23 (Rev. 3) – Special working hours

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 23 (Rev. 3) entitled “Special working hours”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to staff members and fellows. It cancels and replaces Administrative Circular No. 23 (Rev. 2) entitled “Special working hours” of December 2008. Paragraph 6 a) of Annex II of this circular was revised following the modification of Article III 1.04 of the Staff Regulations approved by Council on 14 December 2012. The modification serves to adapt the minimum rest time to the fact that, in case of rapidly alternating shifts, a maximum of seven consecutive shifts may be performed. Department Head Office HR Department

  7. Administrative circular n°11 (REV. 2) – Categories of members of the personnel

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 May 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department. This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 1) entitled “Categories of members of the personnel” of January 1997 as regards all contracts of members of the personnel issued on or after 1 January 2013. The circular was revised in order to take into account developments since the last revision of the categories of personnel in 1997 as well as the needs of the Organization and collaborating institutes. In particular, it introduces a new system for distinguishing categories of associated members of the personnel, namely with regard to the purpo...

  8. RevPAR、收益管理与收益管理经理

    Institute of Scientific and Technical Information of China (English)

    王大悟

    2013-01-01

    一、RevPAR这是酒店业熟悉的指标,即每间可供出租客房的实际平均房价,以客房门市价与出租率的乘积得出。这个指标至少考量了出租率与房价两个重要因素的组合,单纯出租率和房价并不能科学反映酒店的经营业绩。因此到目前为止,RevPAR依然是衡量与比较酒店经营状况的一个标准。

  9. ED becomes 'lean' and cuts LBTC, LOS times.

    Science.gov (United States)

    2008-04-01

    Lean manufacturing techniques, first developed by Toyota, can be successfully adapted to help improve processes in your ED. St. Luke's Episcopal Hospital in Houston, has used Lean to reduce median length of stay, frequency of diversions, and the percentage of patients who left before treatment was complete (LBTC). Here's why "Lean" can help improve the performance of your ED: It enables you and your staff to see things from the patient's point of view. Lean tools enable you to view the status of your department in real-time and to compare that status with your performance goals. Exercises help identify areas where your processes break down and determine the most likely solutions.

  10. Reduction of Electron Channeling in EDS using Precession

    OpenAIRE

    Liao, Yifeng; Marks, Laurence D.

    2012-01-01

    We demonstrate that EDS measurement can be significantly improved by precessing the electron beam, thereby reducing electron channeling effects. For a SrTiO3 specimen orientated along [001] zone axis, the measured strontium to titanium atomic ratio was 0.74 – 0.80 using conventional EDS methods, and the ratio was improved to ~0.99 by precessing the electron beam for angles greater than 22.54 mRad. In ALCHEMI-like experiments in which the specimen was tilted to near two-beam condition, the str...

  11. New psych unit eases patient burden in ED.

    Science.gov (United States)

    2008-06-01

    Creating a special unit for psychiatric patients frees up beds in your ED, ensures better care for that patient population, and improves the atmosphere in the main department for the rest of your patients. Consider these suggestions: The creation of a psych unit can be extremely costly. Be prepared to demonstrate projected savings when pitching the idea to administration. Make sure an ED physician has overall responsibility for each patient at all times. Keep a regular group of nurses in rotation. This setup will help ensure smooth handoffs.

  12. Effects on birds of an offshore wind park at Horns Rev: Environmental impact assessment

    Energy Technology Data Exchange (ETDEWEB)

    Noer, H.; Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [DMU, Dept. of Coastal Zone Ecology (Denmark)

    2000-07-01

    This report presents the technical background to the ornithological environmental impact assessment for the construction of an offshore windpark at Horns Rev, 14 km west-south-west of Blaevandshuk, Denmark. Construction of the park is planned to commence in 2001. The park will consist of c. 80 wind turbines, each of at least 1.8 MW, and cover an area of 27.5 km{sup 2} (including the 200 m exclusion zone around the park). (au)

  13. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2005-05-15

    Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

  14. International AIDS Society conference update. Compound targeting Rev protein promising. Orphaned approach still looking for home.

    Science.gov (United States)

    2005-09-01

    While clinicians and HIV/AIDS patients anxiously watch the trend of the virus developing resistance to multiple antiretroviral therapies, the question remains whether new drug research will continue to save the day. Some suggest there will need to be multiple new classes of antiretroviral drugs developed in order to stretch further the life span of longtime HIV patients. One potential new class would target the Rev protein, an approach that has received very little attention from the research and pharmaceutical communities.

  15. 生物钟基因Rev-erb-α缺失导致雌鼠生理周期延长%Circadian clock gene Rev-erb-α deficiency prolongs female estrous cyclicity

    Institute of Scientific and Technical Information of China (English)

    张芹; 董珍; 吴曦; 颜洁; 高基民

    2013-01-01

    在哺乳动物中,生物节律与生殖生理和生殖内分泌密切相关,流行病学研究显示长期倒时差的女性表现出生殖力低下和不良妊娠的概率更高,但是人们对生物节律影响生殖的机制了解还很少.本研究旨在以时钟基因Rev-erb-α敲除型(Reverb-α-/-)雌性小鼠为模型初步探索生物节律对生殖的影响.将Rev-erb-α-/-和野生型(Rev-erb-α+/+)小鼠与C57BL/6J小鼠交配观察生殖力变化,用苏木精-伊红(HE)染色法观察卵巢组织变化,将Rev-erb-α+/+与Rev-erb-α-/-雌性小鼠分别与C57BL/6J雄性小鼠交配后比较见栓后1.5 d统计的胚胎数量,用阴道涂片结合周期图和周期谱观察小鼠生理周期变化.结果显示,Rev-erb-α-/-雌性小鼠与C57BL/6J雄鼠交配是不生育的,并且Rev-erb-α-/-雌性小鼠生成的胚胎数量明显减少.Rev-erb-α-/-雌性小鼠卵巢存在各级卵泡,并且结构与野生型(Rev-erb-α+/+)雌性小鼠相比无明显差异.Rev-erb-α-/-雌性小鼠的生理周期较Rev-erb-α+/+小鼠周期长约3.22 d,较Rev-erb-α+/+雌性小鼠延长63.5%.以上结果提示,生物钟基因Rev-erb-α缺失导致雌性小鼠生理周期明显延长,可能是影响雌性小鼠生育的原因之一.因此,生物节律的稳定对于生理周期具有重要作用.%The circadian clock has been linked to female reproductive physiology and endocrine in mammals.Epidemiological studies of female shift workers have shown increased rates of abnormal reproduction and adverse pregnancy.But little is known how the circadian rhythms affect reproduction.The aim of the present study was to investigate the influences of circadian rhythms on estrous cycle in female mice using clock gene Rev-erb-α knock out (Rev-erb-α-/-) mice.To test the fertility of Rev-erb-α-/-mice,litter sizes were counted after mating with C57BL/6J male mice.HE staining was used to observe the change of follicle development.The number of embryos of Rev-erb-α+/+ and Rev

  16. Losers, Food, and Sex. Clerical Masculinity in the BBC Sitcom Rev.

    Directory of Open Access Journals (Sweden)

    Alexander Ornella

    2016-11-01

    Full Text Available Clerical masculinities, much like their lay/secular counterparts, often appear unchang¬ing because they are the products of naturalization processes. Clerical masculinities, however, are far from stable, for they live and breathe the dynamics of both their socio-religious context and their secular “others”. The BBC sitcom Rev. (BBC2, UK 2010–2014 is a refreshing take on the everyday life and problems of a vicar in the Church of England trying to avoid stereotypes that often come with clerical roles. Rev. (2010–2014 can be interpreted as an attempt to explore the negotiation processes of masculinity within an institution that is involved in the “production” of religion and gender roles. It shows that being a man in an institutional setting is as much a perfor¬mance as it is a more or less successful negotiation of other people’s expectations and one’s own worldview. In particular, the main male clerical characters in Rev. (2010– 2014 inhabit a position of power but all have their flaws. They can best be understood as losers whose clash with masculine systems renders them more human.

  17. Violence prevention in the ED: linkage of the ED to a social service agency.

    Science.gov (United States)

    Zun, Leslie S; Downey, La Vonne; Rosen, Jodi

    2003-10-01

    was a strong positive correlation of using services and case management (Pearson coefficient = 0.728, significance =.00). The referral of young victims of violence from the ED to psychosocial services could be successful using a case management model and an alliance between a healthcare system and a social service agency.

  18. Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function

    Directory of Open Access Journals (Sweden)

    Myers Michael P

    2011-07-01

    Full Text Available Abstract Background Central to the fully competent replication cycle of the human immunodeficiency virus type 1 (HIV-1 is the nuclear export of unspliced and partially spliced RNAs mediated by the Rev posttranscriptional activator and the Rev response element (RRE. Results Here, we introduce a novel method to explore the proteome associated with the nuclear HIV-1 RNAs. At the core of the method is the generation of cell lines harboring an integrated provirus carrying RNA binding sites for the MS2 bacteriophage protein. Flag-tagged MS2 is then used for affinity purification of the viral RNA. By this approach we found that the viral RNA is associated with the host nuclear matrix component MATR3 (Matrin 3 and that its modulation affected Rev activity. Knockdown of MATR3 suppressed Rev/RRE function in the export of unspliced HIV-1 RNAs. However, MATR3 was able to associate with Rev only through the presence of RRE-containing viral RNA. Conclusions In this work, we exploited a novel proteomic method to identify MATR3 as a cellular cofactor of Rev activity. MATR3 binds viral RNA and is required for the Rev/RRE mediated nuclear export of unspliced HIV-1 RNAs.

  19. Thermally Induced Silane Dehydrocoupling on Silicon Nanostructures (International ed.)

    Science.gov (United States)

    2016-07-29

    Arkles Gelest Inc. 11 East Steel Rd., Morrisville, PA 19067 (USA) Y. W. Jun, Prof. Dr. K. H. Ahn Department of Chemistry Pohang University of Science...Figure 1a) and elemental analysis by energy-dispersive X-ray (EDS) analysis revealed strong carbon and oxygen signals (Table S2). By contrast, a

  20. Ed Henneke receives award for innovation in nondestructive testing research

    OpenAIRE

    Gilbert, Karen

    2005-01-01

    Ed Henneke, of Blacksburg, associate dean for research and graduate studies in the College of Engineering at Virginia Tech, received the Award for Innovation in Nondestructive Testing Research (NDT) at the American Society for Nondestructive Testing's 14th Annual Research Symposium in Albuquerque, N.M. This award was established to recognize highly distinguished individual breakthroughs in research in NDT.

  1. Murray Pittock, ed., The Edinburgh Companion to Scottish Romanticism.

    Directory of Open Access Journals (Sweden)

    Manfred Malzahn

    2013-10-01

    Full Text Available Murray Pittock, ed., The Edinburgh Companion to Scottish Romanticism. Edinburgh: Edinburgh University Press, 2011. Pp. 251. ISBN 978-0-7486-3845-1 (hardback. £ 65.00. ISBN 978-0-7486-3846-8 (paperback. £ 21.99.

  2. Review: Askew, Mark (ed.: Legitimacy Crisis in Thailand

    Directory of Open Access Journals (Sweden)

    Napisa Waitoolkiat

    2011-01-01

    Full Text Available Review of the edited volume: Askew, Mark (ed. (2010, Legitimacy Crisis in Thailand, Chiang Mai, Thailand: Silkworm Books (= King Prajadhipok’s Institute Yearbook No. 5 (2008/09. ISBN 978-974-9511-97-8, 340 pages

  3. Inside the Sex Ed Studio: An Interview with Peggy Brick

    Science.gov (United States)

    Taverner, William J.

    2008-01-01

    "Inside the Sex Ed Studio" profiles leaders in the field of sexuality education. Peggy Brick, former director of Planned Parenthood of Greater Northern New Jersey's Center for Family Life Education (CFLE) and author of numerous sexuality education resources used worldwide, is the subject of this interview. Ms. Brick was interviewed by…

  4. Creating a Minnesota Statewide SNAP-Ed Program Evaluation

    Science.gov (United States)

    Gold, Abby; Barno, Trina Adler; Sherman, Shelley; Lovett, Kathleen; Hurtado, G. Ali

    2013-01-01

    Systematic evaluation is an essential tool for understanding program effectiveness. This article describes the pilot test of a statewide evaluation tool for the Supplemental Nutrition Assistance Program-Education (SNAP-Ed). A computer algorithm helped Community Nutrition Educators (CNEs) build surveys specific to their varied educational settings…

  5. Engaging the public through writing an op-ed

    Science.gov (United States)

    Labosier, Chris; Zhu, Laiyin; Quiring, Steven

    2012-10-01

    In May, prior to the start of the 2012 hurricane season, AGU asked us to write an op-ed for the Houston Chronicle on the importance of funding hurricane research. We were excited to be asked and pleased that AGU facilitated the process by providing us with some guidance on writing the op-ed. Given the impact that Hurricane Ike had in Texas just a few years ago, we felt it was important to remind the citizens of the greater Houston metropolitan area of the societal benefits of funding hurricane research. Thanks to the assistance of AGU staff, writing the article required only a few hours of time. Our op-ed was published in the print edition of the Houston Chronicle on 1 June 2012, the official start of the hurricane season (http://www.chron.com/default/article/Tight-budgets-posing-threat-to-Texas-hurricane-3600363.php). It was picked up by the media relations office in the College of Geosciences at Texas A&M University and featured on the college's Web site in the dean's biweekly briefing and on its Facebook page. As a result, the op-ed reached a large and diverse audience.

  6. Candidate Success and edTPA: Looking at the Data

    Science.gov (United States)

    Evans, Lesley A.; Kelly, Mary K.; Baldwin, Joni L.; Arnold, Jackie M.

    2016-01-01

    This descriptive study looks at the correlations between Teacher Performance Assessment (edTPA) data and numerous program data points, including GPA, major GPA, and benchmark assignment scores, gathered in an Early Childhood Education (ECE) program. Previous studies have looked to correlate grade point average (GPA) with pre-service teacher…

  7. Lifeworld and Textualism: Reassembling the Researcher/ed and "Others"

    Science.gov (United States)

    Payne, Phillip G.

    2005-01-01

    This response to McKenzie's "post-post" concerns about environmental education research draws upon empirical, conceptual, anecdotal, metaphorical, imaged and poetic means to help the researcher "reassemble" the researcher/ed by attending to her/his relational body and embodiment of various, often hegemonic, socially constructed environmental…

  8. TRAUMA (RE-)IMAG(IN)ED: EXPERIENCES AND MEMORIES OF ...

    African Journals Online (AJOL)

    imitch

    terms what trauma is, and interfaces it with how Soyinka has (re-)imag(in)ed it and submits ... innermost and visceral thoughts and being of his characters. .... Like The Man Died, Madmen and Specialists arose from Soyinka's painful and traumatic acquaintance ... out of the period, which I stayed in prison, which was just over.

  9. Status report of seabird surveys at Horns Rev, 2000-2001

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [NERI, Dept. of Coastal Zone Ecology, Roskilde (Denmark)

    2002-07-01

    The present report presents the results of three bird surveys conducted in the Horns Rev area during the second half of 2001. Due to poor weather conditions in December 2001, the last survey was, however, performed on 7 January 2002. The surveys are part of the base-line investigations of birds performed in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. The results of the surveys during August 2001 - January 2002 are presented together with the results obtained during the period August 2000 - April 2001, and are also compared to results obtained during the period August 1999 - April 2000. Based on the distribution of the most abundant bird species recorded during 16 aerial surveys performed during August 1999 - January 2002, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, mainly occurring in the areas north and south of Horns Rev, and with low numbers on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common Scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although common scoter was found in relatively high numbers on the southeast slopes of the Horns Rev and within the wind farm area in the April 2001 survey. Common scoters occurred in very high numbers in January 2002. This was probably related to increased immigration of birds from the inner Danish waters during a cold period in late December 2001. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affect less than 1% of the various species, except divers where 1.58% will be

  10. TrED: the Trichophyton rubrum Expression Database

    Directory of Open Access Journals (Sweden)

    Liu Tao

    2007-07-01

    Full Text Available Abstract Background Trichophyton rubrum is the most common dermatophyte species and the most frequent cause of fungal skin infections in humans worldwide. It's a major concern because feet and nail infections caused by this organism is extremely difficult to cure. A large set of expression data including expressed sequence tags (ESTs and transcriptional profiles of this important fungal pathogen are now available. Careful analysis of these data can give valuable information about potential virulence factors, antigens and novel metabolic pathways. We intend to create an integrated database TrED to facilitate the study of dermatophytes, and enhance the development of effective diagnostic and treatment strategies. Description All publicly available ESTs and expression profiles of T. rubrum during conidial germination in time-course experiments and challenged with antifungal agents are deposited in the database. In addition, comparative genomics hybridization results of 22 dermatophytic fungi strains from three genera, Trichophyton, Microsporum and Epidermophyton, are also included. ESTs are clustered and assembled to elongate the sequence length and abate redundancy. TrED provides functional analysis based on GenBank, Pfam, and KOG databases, along with KEGG pathway and GO vocabulary. It is integrated with a suite of custom web-based tools that facilitate querying and retrieving various EST properties, visualization and comparison of transcriptional profiles, and sequence-similarity searching by BLAST. Conclusion TrED is built upon a relational database, with a web interface offering analytic functions, to provide integrated access to various expression data of T. rubrum and comparative results of dermatophytes. It is devoted to be a comprehensive resource and platform to assist functional genomic studies in dermatophytes. TrED is available from URL: http://www.mgc.ac.cn/TrED/.

  11. WBN-1 Cycle 10 TPBAR Tritium Release, Deduced From Analysis of RCS Data TTP-1-3046-00, Rev 0

    Energy Technology Data Exchange (ETDEWEB)

    Shaver, Mark W.; Niehus, Mark T.; Love, Edward F.

    2012-02-19

    This document contains the calculation of the TPBAR tritium release from the Mark 9.2 design TPBARs irradiated in WBN cycle 10. The calculation utilizes the generalized cycle analysis methodology given in TTP-1-3045 Rev. 0.

  12. DC Brushless Motor Control Design and Preliminary Testing for Independent 4-Wheel Drive Rev-11 Robotic Platform

    Directory of Open Access Journals (Sweden)

    Roni Permana Saputra

    2012-03-01

    Full Text Available This paper discusses the design of control system for brushless DC motor using microcontroller ATMega 16 that will be applied to an independent 4-wheel drive Mobile Robot LIPI version 2 (REV-11. The control system consists of two parts which are brushless DC motor control module and supervisory control module that coordinates the desired command to the motor control module. To control the REV-11 platform, supervisory control transmit the reference data of speed and direction of motor to control the speed and direction of each actuator on the platform REV-11. From the test results it is concluded that the designed control system work properly to coordinate and control the speed and direction of motion of the actuator motor REV-11 platform. 

  13. Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.

    2000-03-15

    An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

  14. Pilot power based rate control in CDMA 2000 1x EV-DO Rev-A

    Institute of Scientific and Technical Information of China (English)

    LIU Xiao-feng; GU Jian; YANG Hong-wen

    2008-01-01

    This article proposes a new algorithm to improvethe rate control efficiency of enhanced reverse link mediumaccess control (RLMAC) in the code division multiple access(CDMA) lx EV-DO release A(Rev. A) system. The newalgorithm brings reverse access terminal (AT) pilot power tothe RLMAC rate control procedure and makes it easier for alow pilot power user to increase its data rate when the systemis slightly loaded and harder to decrease its date rate when thesystem is heavily loaded. Numerical results of system levelsimulations show that the new algorithm can bring highersystem throughput, lower AT transmission power, and lowersystem load.

  15. De novo mutations in Plxnd1 and Rev3l cause mobius syndrome

    OpenAIRE

    Kayserili Karabey, Hülya; Tomas-Roca, Laura; Tsaalbi-Shtylik, Anastasia; Jansen, Jacob G.; Singh, Manvendra K.; Epstein, Jonathan A.; Altunoglu, Umut; Verzijl, Harriette; Soria, Laura; van Beusekom, Ellen; Roscioli, Tony; Iqbal, Zafar; Gilissen, Christian; Hoischen, Alexander; de Brouwer,Arjan P. M.; Erasmus, Corrie; Schubert, Dirk; Brunner, Han; Aytes, Antonio Perez; Marin, Faustino; Aroca, Pilar; Carta, Arturo; de Wind, Niels; Padberg, George W.; van Bokhoven, Hans

    2015-01-01

    ARTICLE Received 15 Nov 2014 | Accepted 17 Apr 2015 | Published 12 Jun 2015 De novo mutations in PLXND1 and REV3L cause Mo¨bius syndrome Laura Tomas-Roca1,2, Anastasia Tsaalbi-Shtylik3, Jacob G. Jansen3, Manvendra K. Singh4,5, Jonathan A. Epstein4, Umut Altunoglu6, Harriette Verzijl7, Laura Soria1, Ellen van Beusekom1, Tony Roscioli1,8, Zafar Iqbal1, Christian Gilissen1, Alexander Hoischen9, Arjan P.M. de Brouwer1, Corrie Erasmus7, Dirk Schubert10, Han Brunner1,11, Antoni...

  16. Simulaton of the Avedøreværket Unit 1 Cogeneration Plant with DNA

    DEFF Research Database (Denmark)

    Elmegaard, Brian; Houbak, Niels

    2003-01-01

    The simulator contest proposed for the ECOS 2003 conference has been solved using the DNA energy system simulator. The contest concerns the steam process of the Avedøreværket Unit 1 (AVV1) power plant. The plant is a 250 MWCHP plant with a maximum district heat production of 330 MJ/s. The plant has...... a brief description of the DNA simulator, as well as a short notice on some of the component models used. In particular, there is a small investigation of the difference obtained in the solution depending on the model used for the turbine (isentropic efficiency, polytropic efficiency, or straight...

  17. Bird numbers and distributions in the Horns Rev offshore wind farm area. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Krag Petersen, I.

    2005-07-01

    This report presents data from four aerial surveys of birds in the Horns Rev wind farm area in 2004. Three surveys from the winter and spring of 2004 are thoroughly reported here. The fourth survey of 9 September 2004 is reported in general terms, but not included in presentations of distribution and effect analyses of the wind farm. Data from this survey will be thoroughly dealt with in a future report. Including the four surveys of 2004, a total of 29 surveys have been performed in that area since August 1999. (au)

  18. CTL Responses to Regulatory Proteins Tat and Rev in HIV-1 B'/C Virus-Infected Individuals

    Institute of Scientific and Technical Information of China (English)

    MING-MING JIA; KUN-XUE HONG; JIAN-PING CHEN; HONG-WEI LIU; SHA LIU; XIAO-QING ZHANG; HONG-JING ZHAO; YI-MING SHAO

    2008-01-01

    To characterize HIV-1 specific CTL responses to regulatory proteins Tat and Rev in HIV-B'/C vires-infected ART-naive individuals. Methods HIV-1-specific CTL responses were analyzed by IFN-γ ELISPOT assay using overlapping peptides spanning the consensus sequences of HIV-1 clade C Tat and Rev proteins. Statistical analysis and graphical presentation were performed using SIGMAPLOT 10.0 and SIGMASTAT 3.5. For samples with a positive response, the magnitude of CTL responses was compared between HIV-1 C proteins by Wilcoxon rank sum test, and the significance threshold was P<0.05. Results Tat and Rev were frequently recognized, with 23% and 52% of the tested individuals having detectable responses to these proteins, respectively. Several immunodominant regions were detected in Rev. No significant correlation was observed between the magnitude and breadth of CTL responses to regulatory proteins and the control of virus replication in this study. Conclusion Tat and Rev can serve as targets for HIV-1-specific CTL, and several immunodominant regions are detectable in Rev. Further characterization of epitopes and their role in virus control may shed light on pathogenesis of HIV-1 natural infection and also be useful for the design and testing of candidate vaccines.

  19. HIV-1 Rev protein specifies the viral RNA export pathway by suppressing TAP/NXF1 recruitment.

    Science.gov (United States)

    Taniguchi, Ichiro; Mabuchi, Naoto; Ohno, Mutsuhito

    2014-06-01

    Nuclear RNA export pathways in eukaryotes are often linked to the fate of a given RNA. Therefore, the choice of export pathway should be well-controlled to avoid an unfavorable effect on gene expression. Although some RNAs could be exported by more than one pathway, little is known about how the choice is regulated. This issue is highlighted when the human immunodeficiency virus type 1 (HIV-1) Rev protein induces the export of singly spliced and unspliced HIV-1 transcripts. How these RNAs are exported is not well understood because such transcripts should have the possibility of utilizing CRM1-dependent export via Rev or cellular TAP/NXF1-dependent export via the transcription/export (TREX) complex, or both. Here we found that Rev suppressed TAP/NXF1-dependent export of model RNA substrates that recapitulated viral transcripts. In this effect, Rev interacted with the cap-binding complex and inhibited the recruitment of the TREX complex. Thus, Rev controls the identity of the factor occupying the cap-proximal region that determines the RNA export pathway. This ribonucleoprotein remodeling activity of Rev may favor viral gene expression.

  20. Nanoscale voxel spectroscopy by simultaneous EELS and EDS tomography.

    Science.gov (United States)

    Haberfehlner, Georg; Orthacker, Angelina; Albu, Mihaela; Li, Jiehua; Kothleitner, Gerald

    2014-11-01

    Extending the capabilities of electron tomography with advanced imaging techniques and novel data processing methods, can augment the information content in three-dimensional (3D) reconstructions from projections taken in the transmission electron microscope (TEM). In this work we present the application of simultaneous electron energy-loss spectroscopy (EELS) and energy-dispersive X-ray spectroscopy (EDS) to scanning TEM tomography. Various tools, including refined tilt alignment procedures, multivariate statistical analysis and total-variation minimization enable the 3D reconstruction of analytical tomograms, providing 3D analytical metrics of materials science samples at the nanometer scale. This includes volumetric elemental maps, and reconstructions of EDS, low-loss and core-loss EELS spectra as four-dimensional spectrum volumes containing 3D local voxel spectra. From these spectra, compositional, 3D localized elemental analysis becomes possible opening the pathway to 3D nanoscale elemental quantification.

  1. Differential cDNA cloning by enzymatic degrading subtraction (EDS).

    OpenAIRE

    1994-01-01

    We describe a new method, called enzymatic degrading subtraction (EDS), for the construction of subtractive libraries from PCR amplified cDNA. The novel features of this method are that i) the tester DNA is blocked by thionucleotide incorporation; ii) the rate of hybridization is accelerated by phenol-emulsion reassociation; and iii) the driver cDNA and hybrid molecules are enzymatically removed by digestion with exonucleases III and VII rather than by physical partitioning. We demonstrate th...

  2. States leverage telepsychiatry solutions to ease ED crowding, accelerate care.

    Science.gov (United States)

    2015-02-01

    Many states are having success turning to telepsychiatry-based solutions to connect mental health patients with needed care while also decompressing crowded EDs. Just one year into a statewide telepsychiatry initiative in North Carolina (NC-STeP), administrators say the approach has saved as much as $7 million, and hospital demand for the service is higher than anticipated. In Texas, mental health emergency centers (MHEC) that use telepsychiatry to connect patients in rural areas with needed psychiatric care are freeing up EDs to focus on medical care. In just 11 months, 91 North Carolina hospitals have at least started the process to engage in NC-STeP. Much of the savings from NC-STeP come from involuntary commitment orders being overturned as a result of the telepsychiatry consults, reducing the need for expensive inpatient care. Implementing NC-STeP has involved multiple hurdles including credentialing difficulties and technical/firewall challenges. The Texas model provides 24/7 availability of psychiatrists via telemedicine through a network of MHECs. In-person staff at the MHECs perform basic screening tests and blood draws so that medical clearance can be achieved without the need for an ED visit in most cases. Funding for the MHECs comes from the state, hospitals in the region, and local governmental authorities that reap savings or benefits from the initiative.

  3. A BAC clone of MDV strain GX0101 with REV-LTR integration retained its pathogenicity

    Institute of Scientific and Technical Information of China (English)

    SUN AiJun; LAWRENCE Petherbridge; ZHAO YuGuang; LI YanPeng; NAIR Venugopal K; CUI ZhiZhong

    2009-01-01

    The complete genome of Marek's disease virus (MDV) strain GX0101,which was integrated with the LTR sequences of REV,was cloned in Escherichia coli as a bacterial artificial chromosome (BAC).BAC vector sequences were introduced into the US2 locus of the MDV genome by homologous recombination.The viral DNA containing the BAC vector was used to transform Escherichia coli strain of DH10B.Then the recombinant virus was successfully rescued by transfection of the recombinant BAC DNA into primary chicken embryo fibroblast (CEF).This BAC viral clone was named bac-GX0101.When the reconstituted virus was inoculated into 1-day-old birds,visceral tumors could be detected as early as 62 d post infection.There was no difference in growth ability and pathogenicity to birds between the BAC derived virus and its parental virus.The BAC derived virus maintained its oncogenicity and immunosuppressive effects.In conclusion,the complete genome of GX0101 strain was successfully cloned into BAC and the infectious clone was rescued.With the powerful BAC manipulation system,the infectious clone will provide a useful tool for further understanding the functional roles of the inserted REV-LTR sequence in the GX0101 strain of MDV.

  4. High amplitude phase resetting in rev-erbalpha/per1 double mutant mice.

    Directory of Open Access Journals (Sweden)

    Corinne Jud

    Full Text Available Over time, organisms developed various strategies to adapt to their environment. Circadian clocks are thought to have evolved to adjust to the predictable rhythms of the light-dark cycle caused by the rotation of the Earth around its own axis. The rhythms these clocks generate persist even in the absence of environmental cues with a period of about 24 hours. To tick in time, they continuously synchronize themselves to the prevailing photoperiod by appropriate phase shifts. In this study, we disrupted two molecular components of the mammalian circadian oscillator, Rev-Erbalpha and Period1 (Per1. We found that mice lacking these genes displayed robust circadian rhythms with significantly shorter periods under constant darkness conditions. Strikingly, they showed high amplitude resetting in response to a brief light pulse at the end of their subjective night phase, which is rare in mammals. Surprisingly, Cry1, a clock component not inducible by light in mammals, became slightly inducible in these mice. Taken together, Rev-Erbalpha and Per1 may be part of a mechanism preventing drastic phase shifts in mammals.

  5. Impact of prospective verification of intravenous antibiotics in an ED.

    Science.gov (United States)

    Hunt, Allyson; Nakajima, Steven; Hall Zimmerman, Lisa; Patel, Manav

    2016-12-01

    Delay in appropriate antibiotic therapy is associated with an increase in mortality and prolonged length of stay. Automatic dispensing machines decrease the delivery time of intravenous (IV) antibiotics to patients in the emergency department (ED). However, when IV antibiotics are not reviewed by pharmacists before being administered, patients are at risk for receiving inappropriate antibiotic therapy. The objective of this study was to determine if a difference exists in the time to administration of appropriate antibiotic therapy before and after implementation of prospective verification of antibiotics in the ED. This retrospective, institutional review board-approved preimplementation vs postimplementation study evaluated patients 18years or older who were started on IV antibiotics in the ED. Patients were excluded if pregnant, if the patient is a prisoner, if no cultures were drawn, or if the patient was transferred from an outside facility. Appropriate antibiotic therapy was based on empiric source-specific evidence-based guidelines, appropriate pharmacokinetic and pharmacodynamic properties, and microbiologic data. The primary end point was the time from ED arrival to administration of appropriate antibiotic therapy. Of the 1628 evaluated, 128 patients met the inclusion criteria (64 pre vs 64 post). Patients were aged 65.2±17.0years, with most of infections being pneumonia (44%) and urinary tract infections (18%) and most patients being noncritically ill. Time to appropriate antibiotic therapy was reduced in the postgroup vs pregroup (8.1±8.6 vs 15.2±22.8hours, respectively, P=.03). In addition, appropriate empiric antibiotics were initiated more frequently after the implementation (92% post vs 66% pre; P=.0001). There was no difference in mortality or length of stay between the 2 groups. Prompt administration of the appropriate antibiotics is imperative in patients with infections presenting to the ED. The impact of prospective verification of

  6. Health care utilization before and after an outpatient ED visit in older people.

    Science.gov (United States)

    Horney, Carolyn; Schmader, Kenneth; Sanders, Linda L; Heflin, Mitchell; Ragsdale, Luna; McConnell, Eleanor; Hocker, Michael; Hastings, S Nicole

    2012-01-01

    Older adults in the United States receive a significant amount of care in the emergency department (ED), yet the associations between ED and other types of health care utilization have not been adequately studied in this population. The goals of this study were to examine the relationships between health care use before and after an ED visit among older adults. This retrospective cohort study examined health care use among 308 patients 65 years or older discharged from a university-affiliated ED. Proportional-hazards models were used to assess the relationship between pre-ED health care use (primary care physician [PCP], specialist, ED, and hospital) and risk of return ED visits. Older ED patients in this study had visited other types of providers frequently in the previous year (median number of PCP and specialist visits, 4). Patients who used the ED on 2 or more occasions in the previous year were found to have visited their PCP more often than those without frequent ED use (median number of visits, 7.0 vs 4.0; P < .001). Despite more PCP use in this population, frequent ED use was associated with increased risk of a repeat ED visit (hazard ratio, 2.20; 95% confidence interval, 1.15-4.21), in models adjusted for demographics and health status. Older adults who use the ED are also receiving significant amounts of care from other sources; simply providing additional access to care may not improve outcomes for these vulnerable individuals. Published by Elsevier Inc.

  7. Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4.

    Science.gov (United States)

    Feys, B J; Moisan, L J; Newman, M A; Parker, J E

    2001-10-01

    The Arabidopsis EDS1 and PAD4 genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. Phenotypic analysis of eds1 and pad4 null mutants shows that EDS1 and PAD4 are required for resistance conditioned by the same spectrum of R genes but fulfil distinct roles within the defence pathway. EDS1 is essential for elaboration of the plant hypersensitive response, whereas EDS1 and PAD4 are both required for accumulation of the plant defence-potentiating molecule, salicylic acid. EDS1 is necessary for pathogen-induced PAD4 mRNA accumulation, whereas mutations in PAD4 or depletion of salicylic acid only partially compromise EDS1 expression. Yeast two-hybrid analysis reveals that EDS1 can dimerize and interact with PAD4. However, EDS1 dimerization is mediated by different domains to those involved in EDS1-PAD4 association. Co-immunoprecipitation experiments show that EDS1 and PAD4 proteins interact in healthy and pathogen-challenged plant cells. We propose two functions for EDS1. The first is required early in plant defence, independently of PAD4. The second recruits PAD4 in the amplification of defences, possibly by direct EDS1-PAD4 association.

  8. Factors affecting ED length-of-stay in surgical critical care patients.

    Science.gov (United States)

    Davis, B; Sullivan, S; Levine, A; Dallara, J

    1995-09-01

    To determine what patient characteristics are associated with prolonged emergency department (ED) length-of-stay (LOS) for surgical critical care patients, the charts of 169 patients admitted from the ED directly to the operating room (OR) or intensive care unit (ICU) during a 6-week period in 1993 were reviewed. The ED record was reviewed for documentation of factors that might be associated with prolonged ED LOS, such as use of computed tomographic (CT), radiology special procedures, and the number of plain radiographs and consultants. ED LOS was considered to be the time from triage until a decision was made to admit the patient. Using a Cox proportional hazards model, use of CT and special procedures were the strongest independent predictors of prolonged ED length-of-stay. The number of plain radiographs and consultants had only a minimal effect. Use of a protocol-driven trauma evaluation system was associated with a shorter ED LOS. In addition to external factors that affect ED overcrowding, ED patient management decisions may also be associated with prolonged ED length-of-stay. Such ED-based factors may be more important in surgical critical care patients, whose overall ED LOS is affected more by the length of the ED work-up rather than the time spent waiting for a ICU bed or operating suite.

  9. EDS coal liquefaction process development. Phase V. EDS commercial plant study design update. Illinois coal. Volume 1. Main report

    Energy Technology Data Exchange (ETDEWEB)

    Epperly, W. R.

    1981-03-01

    The objectives of the Study Design Update (SDU) were to identify the technical issues facing a potential commercial-size EDS plant design; to provide a reliable basis for estimating the cost of EDS products; and to furnish research guidance to the EDS Project. The SDU consists of two distinct studies in which different processing schemes are used to produce the hydrogen and fuel gas required by the plant. These studies are referred to as the Base Case and the Market Flexibility Sensitivity Case. In the Base Case, hydrogen is generated by steam reforming of the light hydrocarbon gases produced in the plant. Fuel gas is generated by feeding the bottoms stream from the liquefaction section vacuum pipestill to a FLEXICOKING unit. In the FLEXICOKING unit reactor, the bottoms stream is converted to coke; additional liquid product is also recovered. The coke is converted to low-Btu fuel gas in the FLEXICOKING unit gasifier. In the Market Flexibility Sensitivity (MFS) Case, the bottoms stream from the vacuum pipestill is split, and about half is sent to the FLEXICOKING unit for recovery of additional liquid product and production of fuel gas. The remainder of the bottoms stream is converted to hydrogen in a Partial Oxidation Unit. Hence the MFS Case does not consume light hydrocarbon gases produced and they are available for sale. The study of these two cases has demonstrated the importance of bottoms process selection to the economics and thermal efficiency of an EDS plant. Volume 1 - Main Report has been developed to be a stand-alone document. Both the Base Case and Market Flexibility Sensitivity (MFS) Case are covered. This volume includes an overview and detailed case summaries. It also covers economics, product recovery factors, material and energy balances, cost estimates and enviromental considerations.

  10. Is EdF carrying things too far?; EdF va-t-il trop loin?

    Energy Technology Data Exchange (ETDEWEB)

    Jemain, A.; Rouaud, P.O.

    2002-06-01

    Considered as too fast, too dispersed and financially too hazardous, the recent series of acquisitions of Electricite de France (EdF) oblige the French government to make short work of the statute of the French electrical utility. This situation increases the debt of the company and constrains its captive clients (domestic clients and small and medium size companies) to contribute to this unlimited expansionism by paying their electricity a higher price. (J.S.)

  11. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.

    Directory of Open Access Journals (Sweden)

    Keith I Pardee

    2009-02-01

    Full Text Available Heme is a ligand for the human nuclear receptors (NR REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO, and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD. A 1.9 A crystal structure of the REV-ERBbeta LBD, in complex with the oxidized Fe(III form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBbeta complex reveal that the Fe(II form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions.

  12. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.

    Science.gov (United States)

    Pardee, Keith I; Xu, Xiaohui; Reinking, Jeff; Schuetz, Anja; Dong, Aiping; Liu, Suya; Zhang, Rongguang; Tiefenbach, Jens; Lajoie, Gilles; Plotnikov, Alexander N; Botchkarev, Alexey; Krause, Henry M; Edwards, Aled

    2009-02-24

    Heme is a ligand for the human nuclear receptors (NR) REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO), and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD). A 1.9 A crystal structure of the REV-ERBbeta LBD, in complex with the oxidized Fe(III) form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBbeta complex reveal that the Fe(II) form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II) LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions.

  13. Does the Op-Ed Page Have a Chance to Become a Public Forum?

    Science.gov (United States)

    Ciofalo, Andrew; Traverso, Kim

    1994-01-01

    Surveys op-ed page editors, finding that fewer than half of the responding papers have op-ed pages; that professional journalists, public figures, and propagandists dominate the pages; and that editors firmly control the agenda. (SR)

  14. A functional EDS1 ortholog is differentially regulated in powdery mildew resistant and susceptible grapevines and complements an Arabidopsis eds1 mutant.

    Science.gov (United States)

    Gao, Fei; Shu, Xiaomei; Ali, Mohammad Babar; Howard, Susanne; Li, Nan; Winterhagen, Patrick; Qiu, Wenping; Gassmann, Walter

    2010-04-01

    Vitis vinifera (grapevine) is the most economically important deciduous fruit crop, but cultivated grapevine varieties lack adequate innate immunity to a range of devastating diseases. To identify genetic resources for grapevine innate immunity and understand pathogen defense pathways in a woody perennial plant, we focus in this study on orthologs of the central Arabidopsis thaliana defense regulator ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1). The family of EDS1-like genes is expanded in grapevine, and members of this family were previously found to be constitutively upregulated in the resistant variety 'Norton' of the North American grapevine species Vitis aestivalis, while they were induced by Erysiphe necator, the causal agent of grapevine powdery mildew (PM), in the susceptible V. vinifera variety 'Cabernet Sauvignon'. Here, we determine the responsiveness of individual EDS1-like genes in grapevine to PM and salicylic acid, and find that EDS1-like paralogs are differentially regulated in 'Cabernet Sauvignon', while two are constitutively upregulated in 'Norton'. Sequencing of VvEDS1 and VaEDS1 cDNA and genomic clones revealed high conservation in the protein-encoding sequence and some divergence of the promoter sequence in the two grapevine varieties. Complementation of the Arabidopsis eds1-1 mutant showed that the EDS1-like gene with highest predicted amino acid sequence similarity to AtEDS1 from either grapevine varieties is a functional ortholog of AtEDS1. Together, our analyses show that differential susceptibility to PM is correlated with differences in EDS1 expression, not differences in EDS1 function, between resistant 'Norton' and susceptible 'Cabernet Sauvignon'.

  15. A Successful ED Fall Risk Program Using the KINDER 1 Fall RiskAssessment Tool.

    Science.gov (United States)

    Townsend, Ann B; Valle-Ortiz, Marisol; Sansweet, Tracy

    2016-11-01

    Emergency nurses did not perform falls risk assessments routinely on our ED patients; the instrument used was aimed at inpatients. We identified a need to revise fall assessment practices specific to our emergency department. The purpose of the performance improvement project was to reduce ED falls and evaluate the use of an ED-specific fall risk tool, the KINDER 1 Fall Risk Assessment. The plan was to establish fall risk assessment practices at point of ED entry and to decrease total falls.

  16. Molecular cloning and characterization of enhanced disease susceptibility 1 (EDS1) from Gossypium barbadense.

    Science.gov (United States)

    Su, Xiaofeng; Qi, Xiliang; Cheng, Hongmei

    2014-06-01

    Arabidopsis enhanced disease susceptibility 1 (EDS1) plays an important role in plant defense against biotrophic and necrotrophic pathogens. The necrotrophic pathogen Verticillium dahliae infection of Gossypium barbadense could lead to Verticillium wilt which seriously reduces the cotton production. Here, we cloned and characterized a G. barbadense homolog of EDS1, designated as GbEDS1. The full-length cDNA of the GbEDS1 gene was obtained by the technique of rapid-amplification of cDNA ends. The open reading frame of the GbEDS1 gene was 1,647 bp long and encoded a protein of 548 amino acids residues. Comparison of the cDNA and genomic DNA sequence of GbEDS1 indicated that this gene contained a single intron and two exons. Like other EDS1s, GbEDS1 contained a conserved N-terminal lipase domain and an EDS1-specific KNEDT motif. Subcellular localization assay revealed that GbEDS1-green fluorescence protein fusion protein was localized in both cytosol and nucleus. Interestingly, the transcript levels of GbEDS1 were dramatically increased in response to pathogen V. dahliae infection. To investigate the role of GbEDS1 in plant resistance against V. dahliae, a conserved fragment derived from GbEDS1 was used to knockdown the endogenous EDS1 in Nicotiana benthamiana by heterologous virus-induced gene silencing. Our data showed that silencing of NbEDS1 resulted in increased susceptibility to V. dahliae infection in N. benthamiana, suggesting a possible involvement of the novelly isolated GbEDS1 in the regulation of plant defense against V. dahliae.

  17. Treatment of Nausea and Vomiting in Pregnancy: Factors Associated with ED Revisits

    Directory of Open Access Journals (Sweden)

    Brian R. Sharp

    2016-09-01

    Full Text Available Introduction: Nausea and vomiting in pregnancy (NVP is a condition that commonly affects women in the first trimester of pregnancy. Despite frequently leading to emergency department (ED visits, little evidence exists to characterize the nature of ED visits or to guide its treatment in the ED. Our objectives were to evaluate the treatment of NVP in the ED and to identify factors that predict return visits to the ED for NVP. Methods: We conducted a retrospective database analysis using the electronic medical record from a single, large academic hospital. Demographic and treatment variables were collected using a chart review of 113 ED patient visits with a billing diagnosis of “nausea and vomiting in pregnancy” or “hyperemesis gravidarum.” Logistic regression analysis was used with a primary outcome of return visit to the ED for the same diagnoses. Results: There was wide treatment variability of nausea and vomiting in pregnancy patients in the ED. Of the 113 patient visits, 38 (33.6% had a return ED visit for NVP. High gravidity (OR 1.31, 95% CI [1.06-1.61], high parity (OR 1.50 95% CI [1.12-2.00], and early gestational age (OR 0.74 95% CI [0.60-0.90] were associated with an increase in return ED visits in univariate logistic regression models, while only early gestational age (OR 0.74 95% CI [0.59-0.91] was associated with increased return ED visits in a multiple regression model. Admission to the hospital was found to decrease the likelihood of return ED visits (p=0.002. Conclusion: NVP can be difficult to manage and has a high ED return visit rate. Optimizing care with aggressive, standardized treatment in the ED and upon discharge, particularly if factors predictive of return ED visits are present, may improve quality of care and reduce ED utilization for this condition.

  18. Treatment of Nausea and Vomiting in Pregnancy: Factors Associated with ED Revisits

    Science.gov (United States)

    Sharp, Brian R.; Sharp, Kristen M.; Patterson, Brian; Dooley-Hash, Suzanne

    2016-01-01

    Introduction Nausea and vomiting in pregnancy (NVP) is a condition that commonly affects women in the first trimester of pregnancy. Despite frequently leading to emergency department (ED) visits, little evidence exists to characterize the nature of ED visits or to guide its treatment in the ED. Our objectives were to evaluate the treatment of NVP in the ED and to identify factors that predict return visits to the ED for NVP. Methods We conducted a retrospective database analysis using the electronic medical record from a single, large academic hospital. Demographic and treatment variables were collected using a chart review of 113 ED patient visits with a billing diagnosis of “nausea and vomiting in pregnancy” or “hyperemesis gravidarum.” Logistic regression analysis was used with a primary outcome of return visit to the ED for the same diagnoses. Results There was wide treatment variability of nausea and vomiting in pregnancy patients in the ED. Of the 113 patient visits, 38 (33.6%) had a return ED visit for NVP. High gravidity (OR 1.31, 95% CI [1.06–1.61]), high parity (OR 1.50 95% CI [1.12–2.00]), and early gestational age (OR 0.74 95% CI [0.60–0.90]) were associated with an increase in return ED visits in univariate logistic regression models, while only early gestational age (OR 0.74 95% CI [0.59–0.91]) was associated with increased return ED visits in a multiple regression model. Admission to the hospital was found to decrease the likelihood of return ED visits (p=0.002). Conclusion NVP can be difficult to manage and has a high ED return visit rate. Optimizing care with aggressive, standardized treatment in the ED and upon discharge, particularly if factors predictive of return ED visits are present, may improve quality of care and reduce ED utilization for this condition. PMID:27625723

  19. The Staff Association (SA) in the Enlarged Directorate (ED) meeting!

    CERN Multimedia

    Staff Association

    2017-01-01

    The Vice-President and the President presented the plan of activities of the Staff Association for 2017 and expressed the Staff Association’s concerns at the meeting of the Enlarged Directorate (Directors and Heads of Departments and Units) on 3 April. Five topics were presented, starting with the implementation of the decisions made during the 2015 Five-Yearly Review. Five-Yearly Review – Follow-up (see Echo No. 257) 2016 – Key points of implementation Several changes were already implemented in 2016: review of the Staff Rules and Regulations in January 2016 for the diversity aspects, and in September 2016 to incorporate the new career structure and the new salary grid with grades; review of the Administrative Circular No. 26 (Rev. 11) on the “Recognition of Merit”; placement in grades and provisional placement in benchmark jobs of all staff members; definition of guidelines for the 2017 MERIT exercise. The Staff Association was extensively involved in the...

  20. Overlapping cis sites used for splicing of HIV-1 env/nef and rev mRNAs.

    Science.gov (United States)

    Swanson, A K; Stoltzfus, C M

    1998-12-18

    Alternative splicing is used to generate more than 30 human immunodeficiency virus type 1 (HIV-1) spliced and unspliced mRNAs from a single primary transcript. The abundance of HIV-1 mRNAs is determined by the efficiencies with which its different 5' and 3' splice sites are used. Three splice sites (A4c, A4a, and A4b) are upstream of the rev initiator AUG. RNAs spliced at A4c, A4a, and A4b are used as mRNAs for Rev. Another 3' splice site (A5) is immediately downstream of the rev initiator. RNAs spliced at A5 are used as mRNAs for Env and Nef. In this report, primer extension analysis of splicing intermediates was used to show that there are eight branch points in this region, all of which map to adenosine residues. In addition, cis elements recognized by the cellular splicing machinery overlap; the two most 3' branch points overlap with the AG dinucleotides at rev 3' splice sites A4a and A4b. Competition of the overlapping cis sites for different splicing factors may play a role in maintaining the appropriate balance of mRNAs in HIV-1-infected cells. In support of this possibility, mutations at rev 3' splice site A4b AG dinucleotide dramatically increased splicing of the env/nef 3' splice site A5. This correlated with increased usage of the four most 3' branch points, which include those within the rev 3' splice site AG dinucleotides. Consistent with these results, analysis of a mutant in which three of the four env/nef branch points were inactivated indicated that use of splice site A5 was inhibited and splicing was shifted predominantly to the most 5' rev 3' splice site A4c with preferential use of the two most 5' branch points. Our results suggest that spliceosomes formed at rev A4a-4b, rev A4c, and env/nef A5 3' splice sites each recognize different subsets of the eight branch point sequences.

  1. EDS1 mediates pathogen resistance and virulence function of a bacterial effector in soybean

    Science.gov (United States)

    Enhanced disease susceptibility 1 (EDS1) and phytoalexin deficient 4 (PAD4) are well known regulators of both basal and resistance (R) protein-mediated plant defense. We identified two EDS1- (GmEDS1a/b) and one PAD4-like (GmPAD4) protein that are required for resistance signaling in soybean. Consist...

  2. EDS V26 Containment Vessel Explosive Qualification Test Report

    Energy Technology Data Exchange (ETDEWEB)

    Crocker, Robert W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Haroldsen, Brent L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stofleth, Jerome H. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-11-01

    The objective of the test was to qualify the vessel for its intended use by subjecting it to a 1.25 times overtest. The criteria for success are that the measured strains do not exceed the calculated strains from the vessel analysis, there is no significant additional plastic strain on subsequent tests at the rated design load (shakedown), and there is no significant damage to the vessel and attached hardware that affect form, fit, or function. Testing of the V25 Vessel in 2011 established a precedent for testing V26 [2]. As with V25, two tests were performed to satisfy this objective. The first test used 9 pounds of Composition C-4 (11.25 lbs. TNT-equivalent), which is 125 percent of the design basis load. The second test used 7.2 pounds of Composition C-4 (9 lbs. TNT-equivalent) which is 100 percent of the design basis load. The first test provided the required overtest while the second test served to demonstrate shakedown and the absence of additional plastic deformation. Unlike the V25 vessel, which was mounted in a shipping cradle during testing, the V26 vessel was mounted on the EDS P2U3 trailer prior to testing. Visual inspections of the EDS vessel, surroundings, and diagnostics were completed before and after each test event. This visual inspection included analyzing the seals, fittings, and interior surfaces of the EDS vessel and documenting any abnormalities or damages. Photographs were used to visually document vessel conditions and findings before and after each test event.

  3. Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expression

    Directory of Open Access Journals (Sweden)

    Jeang Kuan-Teh

    2011-07-01

    Full Text Available Abstract Post-transcriptional regulation of HIV-1 gene expression is mediated by interactions between viral transcripts and viral/cellular proteins. For HIV-1, post-transcriptional nuclear control allows for the export of intron-containing RNAs which are normally retained in the nucleus. Specific signals on the viral RNAs, such as instability sequences (INS and Rev responsive element (RRE, are binding sites for viral and cellular factors that serve to regulate RNA-export. The HIV-1 encoded viral Rev protein binds to the RRE found on unspliced and incompletely spliced viral RNAs. Binding by Rev directs the export of these RNAs from the nucleus to the cytoplasm. Previously, Rev co-factors have been found to include cellular factors such as CRM1, DDX3, PIMT and others. In this work, the nuclear matrix protein Matrin 3 is shown to bind Rev/RRE-containing viral RNA. This binding interaction stabilizes unspliced and partially spliced HIV-1 transcripts leading to increased cytoplasmic expression of these viral RNAs.

  4. Development of a real-time quantitative RT-PCR to detect REV contamination in live vaccine.

    Science.gov (United States)

    Luan, Huaibiao; Wang, Yixin; Li, Yang; Cui, Zhizhong; Chang, Shuang; Zhao, Peng

    2016-09-01

    Based on the published Avian reticuloendotheliosis virus (REV) whole genome sequence, primers and TaqMan probes were designed and synthesized, and the TaqMan probe fluorescence real-time quantitative RT-PCR (qRT-PCR) method for detecting the REV pol gene was established by optimizing the reaction conditions. Sensitivity analysis showed that the qRT-PCR method had a sensitivity that was 1,000-fold higher than conventional PCR. Additionally, no amplification signals were obtained when we attempted to detect DNA or cDNA of ALV-A/B/J, MDV, CIAV, IBDV, ARV, NDV, AIV, or other viruses, suggesting a high specificity for our method. Various titers of REV were artificially "spiked" into the FPV and MDV vaccines to simulate REV contamination in attenuated vaccines to validate this qRT-PCR method. Our findings indicated that this qRT-PCR method could detect REV contamination at a dose of 1 TCID50/1,000 feathers, which was 10,000-fold more sensitive than the regular RT-PCR detection (10(4) TCID50/1000 feathers).

  5. 一种CDMA EV-DO revA网络性能优化方案的设计%A Kind of Paln Design about Network Property Mayorization Based on CDMA EV-DO Rev A

    Institute of Scientific and Technical Information of China (English)

    李晓堂; 湛邵斌; 谢忠时

    2010-01-01

    CDMA EV-DO Rev.A作为CDMA EV-DO Rel.O技术之后的下一代版本极大地增强了对实时业务的支持.CDMA EV-DO Rev.A除了继续提高数据业务的带宽之外,引入了一系列关键技术,保证各种业务流获得其相应的业务质量保证.提供了一种针对CDMA EV-DO Rev.A QoS算法进行的优化设计方案,以保证更优的网络性能.

  6. Esther Schor, ed. The Cambridge Companion to Mary Shelley

    Directory of Open Access Journals (Sweden)

    Anne BERTON

    2006-06-01

    Full Text Available “Today, whether she is found between staid cloth covers, in paperback, on the screen or in cyberspace, Mary Shelley is everywhere,” writes Esther Schor in her Introduction to this collection of essays (2. Interest in “the Author of Frankenstein” and of other works has grown steadily over the last twenty years, thanks notably to the publication of her Journals (The Journals of Mary Shelley, 1814-1844, ed. Paula R. Feldman and Diana Scott-Kilvert, 2 vols, Oxford: Clarendon, 1987, of her Lette...

  7. Book Review: Digital Forensic Evidence Examination (2nd ed.)

    OpenAIRE

    Gary Kessler

    2010-01-01

    Cohen, F. (2010). Digital Forensic Evidence Examination (2nd ed.). Livermore, CA: ASP Press. 452 pages, ISBN: 978-1-878109-45-3, US$79.Reviewed by Gary C. Kessler, Gary Kessler Associates & Edith Cowan University ()On the day that I sat down to start to write this review, the following e-mailcame across on one of my lists:Person A and Person B write back and forth and create an email thread. Person A then forwards the email to Person C, but changes some wording in the e...

  8. Numerical Modelling of Large-Diameter Steel Piles at Horns Rev

    DEFF Research Database (Denmark)

    Augustesen, Anders Hust; Brødbæk, K. T.; Møller, M.;

    2009-01-01

    Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used as founda......Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used...... as foundation for a wind turbine at Horns Rev located in the Danish sector of the North Sea. The outer diameter of the pile is 4 m and the subsoil at the location consists primarily of sand. The behaviour of the pile is investigated under realistic loading conditions by means of a traditional Winkler...

  9. Update to Rev6 ignition designs NIF, with details about support tent in particular

    Science.gov (United States)

    Haan, S. W.; Berzak Hopkins, L.; Clark, D. S.; Eder, D.; Hammel, B. A.; Hamza, A.; Ho, D.; Jones, O. S.; Kritcher, A.; Lafortune, K.; MacGowan, B. J.; Meezan, N. B.; Milovich, J.; Peterson, J. L.; Robey, H. F.; Salmonson, J. D.; Spears, B. K.; Town, R. P.; Kline, J. L.; Wilson, D. C.; Simakov, A. N.; Yi, S. A.; Nikroo, A.; Huang, H.; Hoover, D.

    2013-10-01

    Ignition experiments on the National Ignition Facility will use an indirectly driven spherical implosion to assemble and ignite a mass of DT fuel. Requirements describing the specifics of the experiment and the corresponding expected performance were established several years prior. These requirements include laser features, target fabrication and characterization, and data obtained from pre-ignition experiments. Since those requirements were originally set, various NIF experiments using surrogate targets have motivated updates to the target designs and requirements. A summary of these updates will be presented. Rev6 designs for CH(Si), C(W), and Be(Cu) will be summarized. One particularly significant change regards the thickness of the tent films supporting the capsule, and the presentation will include updated thickness goals and the experimental motivation for the change. Prepared by LLNL under Contract DE-AC52-07NA27344.

  10. OPERATIONAL CIRCULAR No. 4 (REV. 1) – USE OF VEHICLES BELONGING TO OR RENTED BY CERN

    CERN Multimedia

    2012-01-01

    Operational Circular No. 4 (Rev. 1) entitled “Use of vehicles belonging to or rented by CERN”, approved by the Director-general following discussion in the Standing Concertation Committee meeting of 15 February 2012, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 4 entitled “Conditions for use by members of the CERN personnel of vehicles belonging to or rented by CERN” of April 2003. This new version enables, in particular, to include CERN contractors and their personnel, to harmonize the structure of the circular with other circulars and to simplify the procedures by permitting electronics forms. Department Head Office HR Department

  11. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://https://hr-docs.web.cern.ch/hr-docs/admincirc/admincirc_fr.asp These circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover, in particular, lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you requi...

  12. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp These Circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover in particular lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you require any additional informa...

  13. Ensemble-based forecasting at Horns Rev: Ensemble conversion and kernel dressing

    DEFF Research Database (Denmark)

    Pinson, Pierre; Madsen, Henrik

    methodology. In a first stage, ensemble forecasts of meteorological variables are converted to power through a suitable power curve model. The relevance and benefits of employing a newly developed orthogonal fitting method for the power curve model over the traditional least-squares one are discussed...... predictive distributions. Such a methodology has the benefit of yielding predictive distributions that are of increased reliability (in a probabilistic sense) in comparison with the raw ensemble forecasts, while taking advantage of their high resolution....... of probabilistic forecasts, the resolution of which may be maximized by using meteorological ensemble predictions as input. The paper concentrates on the test case of the Horns Rev wind farm over a period of approximately one year, in order to describe, apply and discuss a complete ensemble-based forecasting...

  14. Indledende undersøgelser af Wave Star lokaliteten ved Horns Rev

    DEFF Research Database (Denmark)

    Kramer, Morten

    Havområdet ved Horns Rev havvindmøllepark er, pga. tilslutningsmulighederne for el, egnet til udbygning med et eller flere demonstrationsanlæg baseret på bølgekraft. Nærværende rapport beskriver detaljerede undersøgelser vedr. placering af den næste skala 1:2 maskine af Wave Star på lokaliteten....... Formålet med nærværende skrift er at beskrive bølgerne på lokaliteten mht. bølgehøjde, -periode og -retning, at estimere årsproduktionen fra en skala 1:2 Wave Star maskine og forventet orientering af maskinen for maksimal årsproduktion samt at vurdere de største bølger i samspil med vandstand som kan...

  15. Bayesian Assessment of Accuracy Properties of Rose Bengal Test in REV-1 Vaccinated Small Ruminants

    Directory of Open Access Journals (Sweden)

    KUJTIM MERSINAJ

    2015-12-01

    Full Text Available The live Brucella melitensis Rev-1 strain is considered the best vaccine available for the prevention of brucellosis in small ruminants. In Albania, vaccination of small ruminants with REV-1 has been used under various regimes since 2004. The effectiveness of the vaccination campaigns is monitored through a post vaccination monitoring and surveillance system based on testing vaccinated animals with Rose Bengal Plate Test (RBPT. Regrettably the test accuracy properties such as the sensitivity and specificity have not been validated in vaccinated small ruminants. The lack of knowledge on these properties hampers the correct evaluation of the true sero-conversion rate of the post vaccination monitoring at national and at flock scale. This study addressed this issue by using a Bayesian modelling framework to estimate two serological tests the RBPT which is the standard serological test used in the post vaccination monitoring and Complement Fixation Test (CFT. Serum samples from 191 reportedly vaccinated small ruminants were tested in parallel with RBPT and CFT. The estimates of sensitivity and specificity values of RBPT were 91% (95% CrI: 82 -98 and 89% (95% CrI: 70 - 98. For CFT the sensitivity resulted 86% (95% CrI: 70 - 95 and the specificity 95% (95% CrI: 80 - 99. The good sensitivity and acceptable specificity of RBPT support its utilization as screening test for post vaccination monitoring. The interpretation of the post vaccination data with RBPT are well acceptable at national level but not well suited for flock status interpretation. In terms of disease diagnosis, especially for a latter phase of the brucellosis control strategy in Albania, both tests could justify their use in association.

  16. Role of AtPolζ, AtRev1, and AtPolη in UV light-induced mutagenesis in Arabidopsis.

    Science.gov (United States)

    Nakagawa, Mayu; Takahashi, Shinya; Tanaka, Atsushi; Narumi, Issay; Sakamoto, Ayako N

    2011-01-01

    Translesion synthesis (TLS) is a DNA damage tolerance mechanism in which DNA lesions are bypassed by specific polymerases. To investigate the role of TLS activities in ultraviolet light-induced somatic mutations, we analyzed Arabidopsis (Arabidopsis thaliana) disruptants of AtREV3, AtREV1, and/or AtPOLH genes that encode TLS-type polymerases. The mutation frequency in rev3-1 or rev1-1 mutants decreased compared with that in the wild type, suggesting that AtPolζ and AtRev1 perform mutagenic bypass events, whereas the mutation frequency in the polh-1 mutant increased, suggesting that AtPolη performs nonmutagenic bypass events with respect to ultraviolet light-induced lesions. The rev3-1 rev1-1 double mutant showed almost the same mutation frequency as the rev1-1 single mutant. The increased mutation frequency found in polh-1 was completely suppressed in the rev3-1 polh-1 double mutant, indicating that AtPolζ is responsible for the increased mutations found in polh-1. In summary, these results suggest that AtPolζ and AtRev1 are involved in the same (error-prone) TLS pathway that is independent from the other (error-free) TLS pathway mediated by AtPolη.

  17. Constitutive disease resistance requires EDS1 in the Arabidopsis mutants cpr1 and cpr6 and is partially EDS1-dependent in cpr5.

    Science.gov (United States)

    Clarke, J D; Aarts, N; Feys, B J; Dong, X; Parker, J E

    2001-05-01

    The systemic acquired resistance (SAR) response in Arabidopsis is characterized by the accumulation of salicylic acid (SA), expression of the pathogenesis-related (PR) genes, and enhanced resistance to virulent bacterial and oomycete pathogens. The cpr (constitutive expressor of PR genes) mutants express all three SAR phenotypes. In addition, cpr5 and cpr6 induce expression of PDF1.2, a defense-related gene associated with activation of the jasmonate/ethylene-mediated resistance pathways. cpr5 also forms spontaneous lesions. In contrast, the eds1 (enhanced disease susceptibility) mutation abolishes race-specific resistance conferred by a major subclass of resistance (R) gene products in response to avirulent pathogens. eds1 plants also exhibit increased susceptibility to virulent pathogens. Epistasis experiments were designed to explore the relationship between the cpr- and EDS1-mediated resistance pathways. We found that a null eds1 mutation suppresses the disease resistance phenotypes of both cpr1 and cpr6. In contrast, eds1 only partially suppresses resistance in cpr5, leading us to conclude that cpr5 expresses both EDS1-dependent and EDS1-independent components of plant disease resistance. Although eds1 does not prevent lesion formation on cpr5 leaves, it alters their appearance and reduces their spread. This phenotypic difference is associated with increased pathogen colonization of cpr5 eds1 plants compared to cpr5. The data allow us to place EDS1 as a necessary downstream component of cpr1- and cpr6-mediated responses, but suggest a more complex relationship between EDS1 and cpr5 in plant defense.

  18. Administrative Circular No. 30 (Rev. 3) - “Financial benefits on taking up appointment and on termination of contract”

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 30 (Rev. 3) entitled “Financial benefits on taking up appointment and on termination of contract”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, is available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 30 (Rev. 3) is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 30 (Rev. 2/Corr.) entitled "Financial benefits on taking up appointment and on termination of contract” of September 2009. This circular was revised in order to implement the modifications introduced into the Staff Rules and Regulations in January 2013 relating to the introduction of the status of Associate Member States and new categories of associated members of the personnel. In particular, the notion of “Member State” in Annexe II (&a...

  19. Administrative Circular No. 30 (Rev. 3) - “Financial benefits on taking up appointment and on termination of contract”

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 30 (Rev. 3) entitled “Financial benefits on taking up appointment and on termination of contract”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, is available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 30 (Rev. 3) is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 30 (Rev. 2/Corr.) entitled "Financial benefits on taking up appointment and on termination of contract” of September 2009. This circular was revised in order to implement the modifications introduced into the Staff Rules and Regulations in January 2013 relating to the introduction of the status of Associate Member States and new categories of associated members of the personnel. In particular, the notion of “Member State” in Annexe II (&a...

  20. Protection against brucellosis in goats, five years after vaccination with reduced-dose Brucella melitensis Rev 1 vaccine.

    Science.gov (United States)

    Díaz-Aparicio, E; Hernández, L; Suárez-Güemes, F

    2004-02-01

    The protection conferred by the reduced-dose Rev 1 Brucella melitensis vaccine in goats that had been immunized 5 years previously was evaluated. Sixteen goats vaccinated 5 years before with Rev 1 (1 x 10(5) cfu) and 5 non-vaccinated goats were challenged with B. melitensis 16M (4 x 10(5) cfu) using the conjunctival route. After giving birth or aborting, the goats were sacrificed and tissue samples were taken for bacteriological study. The challenge strain was recovered in 12%, of the animals from the vaccinated group, and in (80% of the control group. It is concluded, therefore that the use of reduced-dose Rev 1 protects goats vaccinated in endemic areas for at least 5 years after immunization.

  1. Administrative Circular No. 2 (Rev. 7) - Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Multimedia

    2015-01-01

    Administrative Circular No. 2 (Rev. 7), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion at the Standing Concertation Committee meeting held on 17 February 2015 is available via the following link: AC No. 2 (Rev.7).   This revised circular cancels and replaces Administrative Circular No. 2 (Rev. 6), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" and dated January 2015. The circular was revised in order to implement the amendment to Article R II 1.17 of the Staff Regulations, which introduces the possibility of extending limited-duration (LD) contracts up to a maximum total duration of eight years from the previous duration of five years. The award of indefinite contracts will continue to be subject to the outcome of a competitive process. Department Head Of...

  2. Domestic violence in an inner-city ED.

    Science.gov (United States)

    Ernst, A A; Nick, T G; Weiss, S J; Houry, D; Mills, T

    1997-08-01

    A confidential written survey was conducted at the emergency department (ED) of Charity Hospital in New Orleans to determine the prevalence of domestic violence (DV) for male and female ED patients and to determine the demographics of DV. Four violence parameters were calculated for patients who had a partner at the time of presentation: 1) present physical; 2) present nonphysical; 3) past physical; and 4) past nonphysical. Out of the 516 patients enrolled, 283 were women and 233 were men. On the basis of Index of Spouse Abuse scoring, 14% of men and 22% of women had experienced past nonphysical violence, and 28% of men and 33% of women had experienced past physical violence. Of the 157 men and 207 women with partners at the time of presentation, 11% men and 15% women reported present nonphysical violence, and 20% men and 19% of the women reported present physical violence. Logistic-regression models demonstrated that women experienced significantly more past and present nonphysical violence but not physical violence than men. Alcohol, drug use, and suicidal ideation were found to be significant predictors associated with DV. In conclusion, DV rates were high in the New Orleans population, with nearly equal rates of past and present physical violence for men and women.

  3. The collection of MicroED data for macromolecular crystallography.

    Science.gov (United States)

    Shi, Dan; Nannenga, Brent L; de la Cruz, M Jason; Liu, Jinyang; Sawtelle, Steven; Calero, Guillermo; Reyes, Francis E; Hattne, Johan; Gonen, Tamir

    2016-05-01

    The formation of large, well-ordered crystals for crystallographic experiments remains a crucial bottleneck to the structural understanding of many important biological systems. To help alleviate this problem in crystallography, we have developed the MicroED method for the collection of electron diffraction data from 3D microcrystals and nanocrystals of radiation-sensitive biological material. In this approach, liquid solutions containing protein microcrystals are deposited on carbon-coated electron microscopy grids and are vitrified by plunging them into liquid ethane. MicroED data are collected for each selected crystal using cryo-electron microscopy, in which the crystal is diffracted using very few electrons as the stage is continuously rotated. This protocol gives advice on how to identify microcrystals by light microscopy or by negative-stain electron microscopy in samples obtained from standard protein crystallization experiments. The protocol also includes information about custom-designed equipment for controlling crystal rotation and software for recording experimental parameters in diffraction image metadata. Identifying microcrystals, preparing samples and setting up the microscope for diffraction data collection take approximately half an hour for each step. Screening microcrystals for quality diffraction takes roughly an hour, and the collection of a single data set is ∼10 min in duration. Complete data sets and resulting high-resolution structures can be obtained from a single crystal or by merging data from multiple crystals.

  4. Temperature inducible β-sheet structure in the transactivation domains of retroviral regulatory proteins of the Rev family

    Science.gov (United States)

    Thumb, Werner; Graf, Christine; Parslow, Tristram; Schneider, Rainer; Auer, Manfred

    1999-11-01

    The interaction of the human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev with cellular cofactors is crucial for the viral life cycle. The HIV-1 Rev transactivation domain is functionally interchangeable with analog regions of Rev proteins of other retroviruses suggesting common folding patterns. In order to obtain experimental evidence for similar structural features mediating protein-protein contacts we investigated activation domain peptides from HIV-1, HIV-2, VISNA virus, feline immunodeficiency virus (FIV) and equine infectious anemia virus (EIAV) by CD spectroscopy, secondary structure prediction and sequence analysis. Although different in polarity and hydrophobicity, all peptides showed a similar behavior with respect to solution conformation, concentration dependence and variations in ionic strength and pH. Temperature studies revealed an unusual induction of β-structure with rising temperatures in all activation domain peptides. The high stability of β-structure in this region was demonstrated in three different peptides of the activation domain of HIV-1 Rev in solutions containing 40% hexafluoropropanol, a reagent usually known to induce α-helix into amino acid sequences. Sequence alignments revealed similarities between the polar effector domains from FIV and EIAV and the leucine rich (hydrophobic) effector domains found in HIV-1, HIV-2 and VISNA. Studies on activation domain peptides of two dominant negative HIV-1 Rev mutants, M10 and M32, pointed towards different reasons for the biological behavior. Whereas the peptide containing the M10 mutation (L 78E 79→D 78L 79) showed wild-type structure, the M32 mutant peptide (L 78L 81L 83→A 78A 81A 83) revealed a different protein fold to be the reason for the disturbed binding to cellular cofactors. From our data, we conclude, that the activation domain of Rev proteins from different viral origins adopt a similar fold and that a β-structural element is involved in binding to a

  5. Improving ED specimen TAT using Lean Six Sigma.

    Science.gov (United States)

    Sanders, Janet H; Karr, Tedd

    2015-01-01

    Lean and Six Sigma are continuous improvement methodologies that have garnered international fame for improving manufacturing and service processes. Increasingly these methodologies are demonstrating their power to also improve healthcare processes. The purpose of this paper is to discuss a case study for the application of Lean and Six Sigma tools in the reduction of turnaround time (TAT) for Emergency Department (ED) specimens. This application of the scientific methodologies uncovered opportunities to improve the entire ED to lab system for the specimens. This case study provides details on the completion of a Lean Six Sigma project in a 1,000 bed tertiary care teaching hospital. Six Sigma's Define, Measure, Analyze, Improve, and Control methodology is very similar to good medical practice: first, relevant information is obtained and assembled; second, a careful and thorough diagnosis is completed; third, a treatment is proposed and implemented; and fourth, checks are made to determine if the treatment was effective. Lean's primary goal is to do more with less work and waste. The Lean methodology was used to identify and eliminate waste through rapid implementation of change. The initial focus of this project was the reduction of turn-around-times for ED specimens. However, the results led to better processes for both the internal and external customers of this and other processes. The project results included: a 50 percent decrease in vials used for testing, a 50 percent decrease in unused or extra specimens, a 90 percent decrease in ED specimens without orders, a 30 percent decrease in complete blood count analysis (CBCA) Median TAT, a 50 percent decrease in CBCA TAT Variation, a 10 percent decrease in Troponin TAT Variation, a 18.2 percent decrease in URPN TAT Variation, and a 2-5 minute decrease in ED registered nurses rainbow draw time. This case study demonstrated how the quantitative power of Six Sigma and the speed of Lean worked in harmony to improve

  6. Administrative circular No. 2 (Rev. 5) – Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circular No. 2 (Rev. 5) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 1 September 2011, is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 2 (Rev. 4) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" of September 2009. Department Head Office

  7. Comments on Phys. Rev. D89 (2014) 097101 "Reevaluation of the parton distribution of strange quarks in the nucleon"

    CERN Document Server

    Stolarski, M

    2014-01-01

    The HERMES collaboration in Phys. Rev. D89 (2014) 097101 extracted information about the strange quark density in the nucleon. One of the main results is an observation that the shape of the extracted density is very different from the shapes of the strange quark density from global QCD fits and also from that of the light antiquarks. In this paper systematic studies on the HERMES published multiplicity of pion and kaon data are presented. It is shown that the conclusions concerning the strange quark distribution in the nucleon reached in Phys. Rev. D89 (2014) 097101 are at the moment premature.

  8. A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity.

    Science.gov (United States)

    Boons, Eline; Li, Guangdi; Vanstreels, Els; Vercruysse, Thomas; Pannecouque, Christophe; Vandamme, Anne-Mieke; Daelemans, Dirk

    2014-12-01

    The HIV Rev protein mediates the transport of partially and unspliced HIV mRNA from the nucleus to the cytoplasm. Rev multimerizes on a secondary stem-loop structure present in the viral intron-containing mRNA species and recruits the cellular karyopherin CRM1 to export viral mRNAs from the nucleus to the cytoplasm. Previously we have identified a single-domain intrabody (Nb(190)), derived from a llama heavy-chain antibody, which efficiently inhibits Rev multimerization and suppresses the production of infectious virus. We recently mapped the epitope of this nanobody and demonstrated that Rev residues K20 and Y23 are crucial for interaction while residues V16, H53 and L60 are important to a lesser extent. Here, we generated cell lines stably expressing Nb(190) and assessed the capacity of these cell lines to suppress the replication of different HIV-1 subtypes. These cells stably expressing the single-domain antibody are protected from virus-induced cytopathogenic effect even in the context of high multiplicity of infection. In addition, the replication of different subtypes of group M and one strain of group O is significantly suppressed in these cell lines. Next, we analysed the natural variations of Rev amino acids in sequence samples from HIV-1 infected patients worldwide and assessed the effect of Nb(190) on the most prevalent polymorphisms occurring at the key epitope positions (K20 and Y23) in Rev. We found that Nb(190) was able to suppress the function of these Rev variants except for the K20N mutant, which was present in only 0.7% of HIV-1 sequence populations (n = 4632). Cells stably expressing the single-domain intrabody Nb(190) are protected against virus-induced cytopathogenic effect and display a selective survival advantage upon infection. In addition, Nb(190) suppresses the replication of a wide range of different HIV-1 subtypes. Large-scale sequence analysis reveals that the Nb(190) epitope positions in Rev are well conserved across major HIV-1

  9. Reliability of Concentric, Eccentric and Isometric Knee Extension and Flexion when using the REV9000 Isokinetic Dynamometer

    DEFF Research Database (Denmark)

    de Carvalho Froufe Andrade, Alberto César Pereira; Caserotti, Paolo; de Carvalho, Carlos Manuel Pereira

    2013-01-01

    The aim of this study was to assess the reliability of isokinetic and ISO knee extensor and flexor muscle strength when using the REV9000 (Technogym) isokinetic dynamometer. Moreover, the reliability of several strength imbalance indices and bilateral ratios were also examined. Twenty......). The results of this study showed a high reproducibility in eccentric (0.95-0.97), concentric (0.95-0.96) and isometric (0.93-0.96), isokinetic strength for knee extensor and flexor muscles, thus indicating that the REV9000 isokinetic dynamometer can be used in future sports performance studies. A low...

  10. Registered Nurses and Discharge Planning in a Taiwanese ED: A Neglected Issue?

    Science.gov (United States)

    Chang, Wen; Goopy, Suzanne; Lin, Chun-Chih; Barnard, Alan; Liu, Hsueh-Erh; Han, Chin-Yen

    2016-10-01

    Published research on discharge planning is written from the perspective of hospital wards and community services. Limited research focuses on discharge planning in the emergency department (ED). The objective of this study was to identify ED nurses' perceptions of factors influencing the implementation of discharge planning. This qualitative study collected data from 25 ED nurses through in-depth interviews and a drawing task in which participants were asked to depict on paper the implementation of discharge planning in their practice. Factors influencing discharge planning were grouped into three categories: discharge planning as a neglected issue in the ED, heavy workload, and the negative attitudes of ED patients and their families. The study highlighted a need for effective discharge planning to be counted as an essential clinical competency for ED nurses and factored into their everyday workload. Nurses perceived that organizational culture, and parents' and relatives' attitudes were barriers to implementing discharge teaching in the ED.

  11. SEM-EDS analysis and discrimination of forensic soil.

    Science.gov (United States)

    Cengiz, Salih; Cengiz Karaca, Ali; Cakir, Ismail; Bülent Uner, H; Sevindik, Aytekin

    2004-04-20

    Soils vary among different areas, and have some characteristics because of the natural effects and transfers made by human and other living beings in time. So that forensic examination of soil is not only concerned with the analysis of naturally occurring rocks, minerals, vegetation, and animal matter. It also includes the detection of such manufactured materials such as ions from synthetic fertilizers and from different environments (e.g., nitrate, phosphate, and sulfate) as environmental artifacts (e.g., lead or objects as glass, paint chips, asphalt, brick fragments, and cinders) whose presence may impart soil with characteristics that will make it unique to a particular location. Many screening and analytical methods have been applied for determining the characteristics which differentiate and discriminate the forensic soil samples but none of them easily standardized. Some of the methods that applied in forensic laboratories in forensic soil discrimination are the color comparison of the normal air-dried (dehumidified) and overheated soil samples, macroscopic observation, and low-power stereo-microscopic observation, determination of anionic composition by capillary electrophoresis (CE), and the elemental composition by scanning electron microscope (SEM)-energy dispersive X-ray spectrometer (EDS) and other high sensitivity techniques. The objective of this study was to show the effect of the application of 9 tonnes/cm2 pressure on the elemental compositions obtained by SEM-EDS technique and comparing the discrimination power of the pressed-homogenized and not homogenized forensic soil samples. For this purpose soil samples from 17 different locations of Istanbul were collected. Aliquots of the well mixed samples were dried in an oven at 110-120 degrees C and sieved by using 0.5 mm sieve and then the undersieve fraction(JEO-JSM-5600 equipped with an energy dispersive X-ray spectrometer OXFORD Link-ISIS-300. The samples from top of the sieves were examined with

  12. Prevalence and correlates of erectile dysfunction (ED) and treatment seeking for ED in Asian Men: the Asian Men's Attitudes to Life Events and Sexuality (MALES) study.

    Science.gov (United States)

    Tan, Hui-Meng; Low, Wah Yun; Ng, Chirk Jenn; Chen, Kuang-Kuo; Sugita, Minoru; Ishii, Nobuhisa; Marumo, Ken; Lee, Sung Won; Fisher, William; Sand, Michael

    2007-11-01

    There have been limited multiregional studies in Asia examining the parameters of men's general and sexual health and quality of life in the general population vs. those in clinical cohorts of patients with erectile dysfunction (ED). The aims of the Asian Men's Attitudes to Life Events and Sexuality (Asian MALES) study were to investigate the prevalence of ED, associated health conditions, and ED treatment-seeking patterns in the general male population in five regions of Asia (China, Japan, Korea, Malaysia, and Taiwan). Standardized questionnaire previously used in a similar multiregional study and modified to ensure culturally appropriate content for Asia. Phase I of the study involved 10,934 adult men, aged 20-75 years, who were interviewed using the standardized questionnaire. Phase II of the study involved men with self-reported ED recruited from Phase I and via physician referral, invitations in general practitioner offices, and street interception (total Phase II sample, N = 1,209). The overall prevalence of self-reported ED in the Phase I study population was 6.4%. ED prevalence varied by region and significantly increased with age (P influencer of treatment seeking in all regions except Malaysia. The findings confirm those of existing research on ED in both Asian and non-Asian males: ED is a prevalent condition; the prevalence of ED increases with age and is strongly associated with comorbid conditions; and the majority of men have never sought treatment for their condition. This study highlights a substantial need for the evaluation and treatment of ED in Asian men.

  13. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Bech, M.; Leonhars, S.B.; Pedersen, John

    2004-05-15

    ELSAM and ELTRA have established an offshore wind farm with an output of 160 MW in the waters of Horns Rev 1420 km off Blaevands Huk, which is the most westerly point of Denmark. The first phase of construction of the wind farm started in spring 2002. Before the construction activities took place, a baseline description of the benthos was conducted as a part of an environmental monitoring programme for the establishment of the Horns Rev Offshore Wind Farm. The baseline surveys for the present monitoring programme were conducted in the wind farm area on three occasions: spring 1999, spring 2001 and September 2001. In designated reference areas, surveys were conducted in spring 1999 and September 2001. The reference areas in 1999 and September 2001 were placed at two different geographical locations because the survey in September 2001 was planned to be a part of a fish monitoring programme. A comparison between the baseline study in spring 2001 and the baseline study in autumn 2001 clearly revealed that the biomass of most species increased considerably from spring to September. Despite the increase in biomass, the overall distribution of the species and their relative abundance did not change. In order to use the baseline data to investigate a possible impact after the construction of the wind farm, it was essential to arrange the monitoring programme either in spring or in September 2003, because the baseline studies were conducted in these periods. The monitoring programme was conducted in September 2003 after the wind farm had become operational, parallel with the survey on hard bottom substrates. The impacts of the wind farm on the benthic fauna (infauna) in the area were mainly expected to be due to the alteration of the local currents. As the changes in the currents are only minor, impacts on the water chemistry and on the benthic fauna resulting from hydrodynamic causes were expected to be limited or non-existent. The main objective of the present monitoring

  14. Infauna monitoring Horns Rev offshore wind farm. Annual state report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Bech, M.; Frederiksen, R.; Pedersen, John; Leonhard, S.B.

    2005-04-15

    A total of 40 species were identified from the surveys in the Horns Rev area in September 2004 while 42 species were identified in 2003 and 47 species in September 2001. The decline in the number of species occurred both inside the wind farm and reference areas, which indicates that the decline could be a combination of changes in sediment characteristics and natural variation rather than an effect from the establishment of the wind farm. More species were not associated with the hard substrate at the turbine sites in 2004 compared to 2003, while in 2001, more species were associated with fine-grained sand. The median sediment grain size increased from 2001 to 2003 to 2004, which suggests that the velocity of the current increased, but modelling calculations on current speed predicted a 2% reduction in the wind farm area and up to a 15% reduction very close to the scour protection. These results agreed with the grain sizes found at the stations 5, 25 and 100 metres from the scour protection. At most stations, the medium grain size was 5 metres lower from the scour protection compared with the station 100 metres from the scour protection, which indicates that the velocity of the current was lower close to the scour protection. No significant impact on the infauna in the wind farm area was detectable concerning distance-related effects. Though general reductions in the population size of some of the character species in the surveyed areas might be related to changes in the sediment structure, the infauna community at Horns Rev showed no obvious sign of stress response as a consequence of possible impact from construction and operating activities. New species were observed in 2003 and 2004 and some of these might be a result of sediment characteristics, less predation or natural variation. The recording of other species might be a result of the introduction of hard bottom habitants in the wind farm area. The density of the most abundant bivalves and bristle worms was

  15. Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

    Directory of Open Access Journals (Sweden)

    Wesselingh Steven L

    2007-07-01

    Full Text Available Abstract Background The Sydney blood bank cohort (SBBC of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1. Although the cohort members have experienced differing clinical courses and now comprise slow progressors (SP as well as long-term nonprogressors (LTNP, longitudinal analysis of nef/long-terminal repeat (LTR sequences demonstrated convergent nef/LTR sequence evolution in SBBC SP and LTNP. Thus, the in vivo pathogenicity of attenuated HIV-1 strains harboured by SBBC members is dictated by factors other than nef/LTR. Therefore, to determine whether defects in other viral genes contribute to attenuation of these HIV-1 strains, we characterized dominant HIV-1 rev alleles that persisted in 4 SBBC subjects; C18, C64, C98 and D36. Results The ability of Rev derived from D36 and C64 to bind the Rev responsive element (RRE in RNA binding assays was reduced by approximately 90% compared to Rev derived from HIV-1NL4-3, C18 or C98. D36 Rev also had a 50–60% reduction in ability to express Rev-dependent reporter constructs in mammalian cells. In contrast, C64 Rev had only marginally decreased Rev function despite attenuated RRE binding. In D36 and C64, attenuated RRE binding was associated with rare amino acid changes at 3 highly conserved residues; Gln to Pro at position 74 immediately N-terminal to the Rev activation domain, and Val to Leu and Ser to Pro at positions 104 and 106 at the Rev C-terminus, respectively. In D36, reduced Rev function was mapped to an unusual 13 amino acid extension at the Rev C-terminus. Conclusion These findings provide new genetic and mechanistic insights important for Rev function, and suggest that Rev function, not Rev/RRE binding may be rate limiting for HIV-1 replication. In addition, attenuated rev alleles may contribute to viral attenuation and long-term survival of HIV-1 infection in a subset of SBBC members.

  16. Analysis of translesion DNA synthesis activity of the human REV1 protein, which is a key player in radiation-induced mutagenesis

    Energy Technology Data Exchange (ETDEWEB)

    Masuda, Yuji; Kamiya, Kenji [Hiroshima Univ., Research Institute for Radiation Biology and Medicine, Kasumi, Hiroshima (Japan)

    2003-07-01

    Ionizing radiation frequently causes oxidative DNA damage in cells. It has been suggested that functions of the REV1 gene are induction of mutations and prevention of cell death caused by ionizing radiation through the damage bypass DNA replication. The gene product possesses a deoxycytidyl transferase activity, which is required for translesion DNA synthesis of a variety of damaged bases and an abasic site. To elucidate molecular mechanisms of the mutagenesis and translesion DNA synthesis, it is important to characterize the enzymatic properties of the REV1 protein. Here, we describe a novel method for purifying the recombinant human REV1 protein and the anzymatic properties of the protein. We established an efficient system for induction of the recombinant human REV1 protein in Escherichia coli cells. The REV1 protein was purified to homogeneity using nickel-chelating sepharose, heparin sepharose and superdex 200 chromatography. When purified by this method, REV1 protein is free of endo-, exonuclease and DNA polymerase activities. The purified REV1 protein is suitable for enzymological studies, and we used this to biochemical characterization. The REV1 protein inserts dCMP opposite templates G, A, T, C and an abasic site and inserts dGMP and dTMP opposite template G. Kinetic analysis provided evidence for high efficiency for dCMP insertion opposite template G and an abasic site, suggesting that the REV1 protein play a role in translesion DNA synthesis of an abasic site. (author)

  17. Fisica e fumetti: Paperone ed il deposito sotterraneo

    CERN Document Server

    Bagnoli, Franco

    2011-01-01

    I fumetti, come i film, spesso utilizzano idee scientifiche "fantasiose". Non ci riferiamo qui alla violazione implicita delle leggi della fisica, cosa permessa in un mondo di fantasia, quanto piuttosto all'uso di spiegazioni fisiche errate che vengono usate in buona fede perch\\'e a riflettono convinzioni molto diffuse, ma sbagliate, sull'interpretazione di fenomeni a partire dai principi fisici. D'altra parte questi errori possono servire a illustrare la corretta applicazione della fisica in una maniera molto pi\\`u accattivante rispetto alla modalit\\'a tradizionale di presentazione. Analizziamo qui l'avventura Paperone ed il deposito sotterraneo di Pezzin e Cavezzano. ----- Comics and cartoon movies sometimes exploit fictitious scientific ideas. It is often the case that these ideas, althought wrong, actually reflect the popular vision of some natural phenomenon. We do not refer here to the implicit violation of physical laws in fictions, a practice allowed by the underlining "poetic licence" of comics. Howe...

  18. EDS V25 containment vessel explosive qualification test report.

    Energy Technology Data Exchange (ETDEWEB)

    Rudolphi, John Joseph

    2012-04-01

    The V25 containment vessel was procured by the Project Manager, Non-Stockpile Chemical Materiel (PMNSCM) as a replacement vessel for use on the P2 Explosive Destruction Systems. It is the first EDS vessel to be fabricated under Code Case 2564 of the ASME Boiler and Pressure Vessel Code, which provides rules for the design of impulsively loaded vessels. The explosive rating for the vessel based on the Code Case is nine (9) pounds TNT-equivalent for up to 637 detonations. This limit is an increase from the 4.8 pounds TNT-equivalency rating for previous vessels. This report describes the explosive qualification tests that were performed in the vessel as part of the process for qualifying the vessel for explosive use. The tests consisted of a 11.25 pound TNT equivalent bare charge detonation followed by a 9 pound TNT equivalent detonation.

  19. ED services: the impact of caring behaviors on patient loyalty.

    Science.gov (United States)

    Liu, Sandra S; Franz, David; Allen, Monette; Chang, En-Chung; Janowiak, Dana; Mayne, Patricia; White, Ruth

    2010-09-01

    This article describes an observational study of caring behaviors in the emergency departments of 4 Ascension Health hospitals and the impact of these behaviors on patient loyalty to the associated hospital. These hospitals were diverse in size and geography, representing 3 large urban community hospitals in metropolitan areas and 1 in a midsized city. Research assistants from Purdue University (West Lafayette, IN) conducted observations at the first study site and validated survey instruments. The Purdue research assistants trained contracted observers at the subsequent study sites. The research assistants conducted observational studies of caregivers in the emergency departments at 4 study sites using convenience sampling of patients. Caring behaviors were rated from 0 (did not occur) to 5 (high intensity). The observation included additional information, for example, caregiver roles, timing, and type of visit. Observed and unobserved patients completed exit surveys that recorded patient responses to the likelihood-to-recommend (loyalty) questions, patient perceptions of care, and demographic information. Common themes across all study sites emerged, including (1) the area that patients considered most important to an ED experience (prompt attention to their needs upon arrival to the emergency department); (2) the area that patients rated as least positive in their actual ED experience (prompt attention to their needs upon arrival to the emergency department); (3) caring behaviors that significantly affected patient loyalty (eg, making sure that the patient is aware of care-related details, working with a caring touch, and making the treatment procedure clearly understood by the patient); and (4) the impact of wait time to see a caregiver on patient loyalty. A number of correlations between caring behaviors and patient loyalty were statistically significant (P loyalty but that occurred least frequently. The study showed through factor analysis that some caring

  20. The calculational VVER burnup Credit Benchmark No.3 results with the ENDF/B-VI rev.5 (1999)

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Gual, Maritza [Centro de Tecnologia Nuclear, La Habana (Cuba). E-mail: mrgual@ctn.isctn.edu.cu

    2000-07-01

    The purpose of this papers to present the results of CB3 phase of the VVER calculational benchmark with the recent evaluated nuclear data library ENDF/B-VI Rev.5 (1999). This results are compared with the obtained from the other participants in the calculations (Czech Republic, Finland, Hungary, Slovaquia, Spain and the United Kingdom). The phase (CB3) of the VVER calculation benchmark is similar to the Phase II-A of the OECD/NEA/INSC BUC Working Group benchmark for PWR. The cases without burnup profile (BP) were performed with the WIMS/D-4 code. The rest of the cases have been carried with DOTIII discrete ordinates code. The neutron library used was the ENDF/B-VI rev. 5 (1999). The WIMS/D-4 (69 groups) is used to collapse cross sections from the ENDF/B-VI Rev. 5 (1999) to 36 groups working library for 2-D calculations. This work also comprises the results of CB1 (obtained with ENDF/B-VI rev. 5 (1999), too) and CB3 for cases with Burnup of 30 MWd/TU and cooling time of 1 and 5 years and for case with Burnup of 40 MWd/TU and cooling time of 1 year. (author)

  1. 77 FR 30546 - Notice of Proposed Information Collection: Comment Request; Form HUD-40221(rev) “LOCCS/VRS Self...

    Science.gov (United States)

    2012-05-23

    ...) ``LOCCS/VRS Self-Help Homeownership Opportunity Program Payment Voucher'' AGENCY: Office of the Assistant... Payment Voucher'' prior to requesting a drawdown of funds through LOCCS/VRS. Title of Proposal: Form HUD-40221(rev) ``LOCCS/VRS Self-help Homeownership Opportunity Program Payment Voucher''. OMB Control...

  2. Specific amino acid residues are involved in substrate discrimination and template binding of human REV1 protein.

    Science.gov (United States)

    Piao, Jinlian; Masuda, Yuji; Kamiya, Kenji

    2010-02-05

    REV1 is a member of the Y-family DNA polymerases, but is atypical in utilizing only dCTP with a preference for guanine (G) as the template. Crystallography of the REV1-DNA-dCTP ternary complex has revealed a unique mechanism by which template G is evicted from the DNA helix and incoming dCTP is recognized by an arginine residue in an alpha-loop, termed the N-digit. To better understand functions of its individual amino acid residues, we made a series of mutant human REV1 proteins. We found that R357 and L358 play vital roles in template binding. Furthermore, extensive mutation analysis revealed a novel function of R357 for substrate discrimination, in addition to previously proposed specific interaction with incoming dCTP. We found that the binding pocket for dCTP of REV1 has also significant but latent affinity for dGTP. The results suggest that the positive charge on R357 could prevent interaction with dGTP. We propose that both direct and indirect mechanisms mediated by R357 ensure specificity for dCTP.

  3. OPERATIONAL CIRCULAR NO2 (REV. 1) - APRIL 1998 'CONDITIONS OF ACCESS TO THE FENCED PARTS OF THE CERN SITE'

    CERN Multimedia

    Human Resources Division

    2001-01-01

    Subsidiary document 'Implementation Measures' (Rev. 2) - April 2001 The subsidiary document has been amended. Copies are available from Divisional Secretariats and at CERN card issue points. Note : Administrative and operational circulars, as well as the lists of those in force, are available for consultation on WWW : ADMINISTRATIVE CIRCULARS OPERATIONAL CIRCULARS

  4. Functions of EDS1-like and PAD4 genes in grapevine defenses against powdery mildew.

    Science.gov (United States)

    Gao, Fei; Dai, Ru; Pike, Sharon M; Qiu, Wenping; Gassmann, Walter

    2014-11-01

    The molecular interactions between grapevine and the obligate biotrophic fungus Erysiphe necator are not understood in depth. One reason for this is the recalcitrance of grapevine to genetic modifications. Using defense-related Arabidopsis mutants that are susceptible to pathogens, we were able to analyze key components in grapevine defense responses. We have examined the functions of defense genes associated with the salicylic acid (SA) pathway, including ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), EDS1-LIKE 2 (EDL2), EDL5 and PHYTOALEXIN DEFICIENT 4 (PAD4) of two grapevine species, Vitis vinifera cv. Cabernet Sauvignon, which is susceptible to E. necator, and V. aestivalis cv. Norton, which is resistant. Both VaEDS1 and VvEDS1 were previously found to functionally complement the Arabidopsis eds1-1 mutant. Here we show that the promoters of both VaEDS1 and VvEDS1 were induced by SA, indicating that the heightened defense of Norton is related to its high SA level. Other than Va/VvEDS1, only VaEDL2 complemented Arabidopsis eds1-1, whereas Va/VvPAD4 did not complement Arabidopsis pad4-1. Bimolecular fluorescence complementation results indicated that Vitis EDS1 and EDL2 proteins interact with Vitis PAD4 and AtPAD4, suggesting that Vitis EDS1/EDL2 forms a complex with PAD4 to confer resistance, as is known from Arabidopsis. However, Vitis EDL5 and PAD4 did not interact with Arabidopsis EDS1 or PAD4, correlating with their inability to function in Arabidopsis. Together, our study suggests a more complicated EDS1/PAD4 module in grapevine and provides insight into molecular mechanisms that determine disease resistance levels in Vitis species native to the North American continent.

  5. Antioxidant status in pregnant ewes vaccinated with Rev 1 against brucellosis

    Directory of Open Access Journals (Sweden)

    W. S. Al- Khafaji

    2012-01-01

    Full Text Available The aim of this study was to examine the changes in the indicators of free radicals and antioxidant activity, represented by malondialdehyde and glutathione peroxidase in the sera of ewes vaccinated with Rev 1 vaccine. The experiment included 28 animals which were divided into four equal groups. Animals of the first and second groups were vaccinated subcutaneously with 2×109 and 2×107 colony forming units (CFU, respectively, whereas the animals of third and fourth groups were vaccinated conjunctively with 2×109 and 2×107 CFU, respectively. Sera were collected monthly for 6 months. Antibody responses were assessed by classical tests (Rose Bengal test, tube agglutination and 2-mercaptoethanol tests in comparison with competitive ELISA. The antibody titers were higher and remained for along period in the subcutaneously vaccinated groups with the two doses compared those vaccinated conjunctively. There was a significant increase in serum glutathione peroxidase activity in the 8th week post vaccination in subcutaneously vaccinated groups and during the 12th week in those vaccinated conjunctively. Significant increase of serum malondialdehyde levels occurred during the 4th week in those vaccinated conjunctively and in 8th week in those vaccinated subcutaneously. This study concluded that the route of administration of the vaccine affects glutathione peroxidase activity and malondialdehyde level, which act as indicators of oxidative stress response, more than the vaccine dose.

  6. Effect of nacelle on the wake meandering in Horns Rev wind farm

    Science.gov (United States)

    Yang, Xiaolei; Foti, Daniel; Sotiropoulos, Fotis

    2016-11-01

    Turbine wake meandering has considerable effects on the velocity deficit and turbulence intensity in the wake. However, the mechanism for wake meandering is still not well understood and low-order models cannot take into account the wake meandering effects accurately. A recent work by Kang, Yang and Sotiropoulos showed that the nacelle has a significant effect on the wake meandering of a hydrokinetic turbine. To examine the nacelle contributions to wake meandering and wake interactions in utility-scale wind farms, we simulate the atmospheric turbulent flow over the Horns Rev wind farm using large-eddy simulation with actuator type models. In a preliminary simulation on a coarse grid using actuator line model for turbine blades without a nacelle model, the computed power shows overall good agreement with field measurements. Fine grid simulations using an actuator surface model for turbine blades with and without a nacelle model are being carried out. The corresponding results will be presented with analysis on wake meandering dynamics using the technique proposed by Horward et al. and Foti et al.. This work was supported by DOE (DE-AC04-94AL85000), Xcel Energy (Grant RD4-13) and Sandia National Laboratories. Computational resources were provided by National Renewable Energy Laboratory and University of Minnesota Supercomputing Institute.

  7. Modeling RNA-ligand interactions: the Rev-binding element RNA-aminoglycoside complex.

    Science.gov (United States)

    Leclerc, F; Cedergren, R

    1998-01-15

    An approach to the modeling of ligand-RNA complexes has been developed by combining three-dimensional structure-activity relationship (3D-SAR) computations with a docking protocol. The ability of 3D-SAR to predict bound conformations of flexible ligands was first assessed by attempting to reconstruct the known, bound conformations of phenyloxazolines complexed with human rhinovirus 14 (HRV14) RNA. Subsequently, the same 3D-SAR analysis was applied to the identification of bound conformations of aminoglycosides which associate with the Rev-binding element (RBE) RNA. Bound conformations were identified by parsing ligand conformational data sets with pharmacophores determined by the 3D-SAR analysis. These "bioactive" structures were docked to the receptor RNA, and optimization of the complex was undertaken by extensive searching of ligand conformational space coupled with molecular dynamics computations. The similarity between the bound conformations of the ligand from the 3D-SAR analysis and those found in the docking protocol suggests that this methodology is valid for the prediction of bound ligand conformations and the modeling of the structure of the ligand-RNA complexes.

  8. Bird numbers and distribution in the Horns Rev offshore wind farm area. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This report presents data from six aerial surveys of birds in the Horns Rev wind farm area in 2003. Including 16 surveys conducted before construction of the wind farm started and three during the construction phase, a total of 25 surveys have been performed in the area since August 1999. Up until August 2002 the study area was surveyed from 26 north-south oriented, parallel transect lines. After that time four short transects were added eastwards from the previously easternmost transect. From August 2002 slight adjustments to the transect lines in the wind farm area had to be made in order to avoid collision, as survey altitude was 76 m and wind turbines are 110 m to highest wing tip. The six surveys in 2003 were performed on 13 February, 16 March, 23 April, 5 September, 4 and 30 December. The operational phase of the wind farm commenced in 2002. Hence the six surveys from 2003 are all considered post-construction data sets. A preliminary evaluation of the potential impact of the wind turbines on bird distributions has been carried out by comparison of these data to those from the 16 pre-construction surveys. (au)

  9. REVS: a radar-based enhanced vision system for degraded visual environments

    Science.gov (United States)

    Brailovsky, Alexander; Bode, Justin; Cariani, Pete; Cross, Jack; Gleason, Josh; Khodos, Victor; Macias, Gary; Merrill, Rahn; Randall, Chuck; Rudy, Dean

    2014-06-01

    Sierra Nevada Corporation (SNC) has developed an enhanced vision system utilizing fast-scanning 94 GHz radar technology to provide three-dimensional measurements of an aircraft's forward external scene topography. This threedimensional data is rendered as terrain imagery, from the pilot's perspective, on a Head-Up Display (HUD). The image provides the requisite "enhanced vision" to continue a safe approach along the flight path below the Decision Height (DH) in Instrument Meteorological Conditions (IMC) that would otherwise be cause for a missed approach. Terrain imagery is optionally fused with digital elevation model (DEM) data of terrain outside the radar field of view, giving the pilot additional situational awareness. Flight tests conducted in 2013 show that REVS™ has sufficient resolution and sensitivity performance to allow identification of requisite visual references well above decision height in dense fog. This paper provides an overview of the Enhanced Flight Vision System (EFVS) concept, of the technology underlying REVS, and a detailed discussion of the flight test results.

  10. Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production.

    Science.gov (United States)

    Na, Hong; Huisman, Willem; Ellestad, Kristofor K; Phillips, Tom R; Power, Christopher

    2010-09-01

    Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analyses were performed in both an infectious FIV molecular clone and a FIV CAT-RRE reporter system. These studies disclosed that the stems within SLA (SA1, 2, 3, 4, and 5) of the RRE were critical but SA6 was not essential for FIV replication and CAT expression. These studies also revealed that the secondary structure rather than an antisense protein (ASP) mediates virus expression and replication in vitro. In addition, a single synonymous mutation within the FIV-RRE, SA3/45, reduced viral reverse transcriptase activity and p24 expression after transfection but in addition also showed a marked reduction in viral expression and production following infection.

  11. C14-Crash. The C14-method and dendrochronology, unveiling the illusion. 2. rev. ed.; C14-Crash. Das Ende der Illusion, mit Radiokarbonmethode und Dendrochronologie datieren zu koennen

    Energy Technology Data Exchange (ETDEWEB)

    Bloess, C.; Niemitz, H.U.

    2000-07-01

    In this second edition of the book, which was published almost three years after the first edition, the authors reiterate and substantiate their doubts as to the basic theories underlying the radiocarbon dating method and the applicability of dendrochronology. (orig/CB) [German] In dieser zweiten Auflage des Buches, die knapp drei Jahre nach der ersten erschien, vertiefen die Autoren ihre Zweifel an den grundlegenden Theorien und den bisherigen Resultaten der Radiokarbonmethode und der Dendrochronologie. (orig./CB)

  12. Continuum of quanta in the final theory. Model of spiral fields. Basic ideas for a compatible physics and a consistent nature science. 4. rev. ed.; Quantenkontinuum in der Finaltheorie. Spiralfeldmodell. Grundgedanken fuer eine Kompatible Physik und eine Konsistente Naturwissenschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hartje, Udo Albert Juergen

    2009-07-01

    The internationally favored direction of the physics sciences looks for the solution of the basic problems in higher and higher energies at impressive research constructions - mockingly mentioned as 'cognition machines' - which surpass itself with its financial efforts each the other. If in this wise shall be found: 'The elementariest bit of all elements' and 'the unity of the whole physics as well as the whole nature sciences at all', then this is a thought aberration. The prognosticated HIGGS-particles may have an exceptional quality; however, they would be very complex objects which integrate an enormous number of effect-quanta h (Planck constants) in their structure: They are with safety not simplicity. They will also not bring a better understanding about the simplicity of the last elements for us. We know since Planck, Poincare, Einstein, Bohr, Heisenberg, Schroedinger, DeBrogue and other well-known physicists that the 'atomos' can have only a diminutiveness discrete not measurable energy. The search with gigantic machines is at all especially nonsensical than it pumps still energy into the processes. However, the elementary consists of fractions from that energy what have well-known smallest particles or weakest radiation in itself puts. The work in hand follows another approach. It grasps nature on a deductive way. I start out from a most general analysis and synthesis of scientific and everyday-language concepts; and I combine that with a principle of 'general physical field' which after Einstein must exist. The dynamic space-time processes of the fields are depicted by graphic means in mathematical spatial coordinate-systems. Through it arises a consistent view over all areas of the knowledge from the most simply over simple structures until to the most complicated phenomena and things: that one are the cognition remained secretive till now obstinately. In the foreground will be originate as important the solution of the puzzle around the 'Dualism of Waves and Particles'. Structures of matter do not consist of any a priori, i.e. out the beginning existing tiniest primordial particles that secondarily swings; but they generate themselves from radiation which does not interrupt their light-fast movement in the interior of particles; and therefore it remains radiation-like. The circulation in itself creates locality; without that the radiation lost their dynamics; and without that this radiation must itself change into electrons: with their secondary turn in the orbital path. The Classic Physics and the Quantum Physics amalgamate into the 'Spiral Field Model' (Model of Spiral Fields). Classic Physics and the Quantum Physics merge in a Model of Spiral Fields into a paramount thought building with a new imagination for radiation and particles. Molecules, atoms and seedless particles have to be analyzed on the new basis. The rich fundus of proven knowledge will help. Problems of the natural sciences which do not find any immediate explanation should be taken in relation to the new thoughts; therewith will the special aspects visible. A single human is not able to it in view of the gigantic range of the accumulated knowledge. (orig.)

  13. Photovoltaic energy conservation: Unlimited power supply. Optimized construction and use of grid-connected solar power systems. 4. rev. ed.; Photovoltaik. Strom ohne Ende. Netzgekoppelte Solarstromanlagen optimal bauen und nutzen

    Energy Technology Data Exchange (ETDEWEB)

    Seltmann, Thomas

    2009-07-01

    The author of the contribution under consideration reports on the essential aspects of the photovoltaics in easily understandable and well structured texts with valuable hints, examples, check lists, diagrams, photos and tables. Beyond this, the author also supplies answers to legal and financial questions. All important data, conditions of power supply (Renewable energy resources act) and the detailed financing calculation are brought up to date.

  14. Guidebook for energy-saving construction. Hitten the point - neutral specialized information for more energy efficiency. 3. rev. and enl. ed.; Ratgeber energiesparendes Bauen. Auf den Punkt gebracht - Neutrale Fachinformationen fuer mehr Energieeffizienz

    Energy Technology Data Exchange (ETDEWEB)

    Koenigstein, T.

    2007-07-01

    Energy conservation measures in the area of buildings can considerably contribute to the planned reduction of CO{sub 2} emissions particularly if they are not only carried out in the field of new buildings but also in existing buildings. In this booklet technical possibilities and bases of constructional thermal insulation in modern construction engineering are described in detail. In this connection the following subjects are gone into: Low-energy houses, bases of heat and humidity technology, correct heating and ventilating, thermal insulation of heating systems and water heaters, renewable energy sources, legal obligations like energy passport, support possibilities, energy diagnosis and counselling. (GL)

  15. Electrical engineering of engineers 2. Alternative current engineering, loci diagrams, transformers, multiphase systems - a lecture and working book for the basic study. 5. rev. ed.; Elektrotechnik fuer Ingenieure 2. Wechselstromtechnik, Ortskurven, Transformator, Mehrphasensysteme - Ein Lehr- und Arbeitsbuch fuer das Grundstudium

    Energy Technology Data Exchange (ETDEWEB)

    Weissgerber, W.

    2005-07-01

    This lecture- and training book covers comprehensively and systematically fundamentals and calculation methods of ac engineering, loci diagrams, transformers and three-phase systems. Many tasks with detailed solutions in the appendix complete theoretical treatises and enable a good preparation for the examination. The latest edition contains an index of applicated definitions, formulas and units. The content: Sinusoidal changing parameters; Calculation of ac grids; Power in the ac circuit; Loci diagrams; transformers; Multi- and three-phase systems. The book directs to students of vocational colleges, technical universities and professional academies. (GL)

  16. Electrical engineering of engineers 1. Direct current engineering and electromagnetic field - a lecture and working book for the basic study. 6., rev. ed.; Elektrotechnik fuer Ingenieure 1. Gleichstromtechnik und Elektromagnetisches Feld - Ein Lehr- und Arbeitsbuch fuer das Grundstudium

    Energy Technology Data Exchange (ETDEWEB)

    Weissgerber, W.

    2005-07-01

    This lecture- and training book covers comprehensively and systematically fundamentals and calculation methods of DC engineering and electromagnetic field. Many tasks with detailed solutions in the appendix complete theoretical treatises and enable a good preparation for the examination. The latest edition contains an index of applicated definitions, formulas and units. The content: Physical fundamentals; Branched and non-branched power circuits; Procedures on grid calculation; Energy and power; Electrostatic field; Magnetic field. The book directs to students of vocational colleges, technical universities and professional academies. (GL)

  17. Electrical engineering of engineers 1. Direct current engineering and electromagnetic field. A lecture and working book for the basic study. 9. rev. ed.; Elektrotechnik fuer Ingenieure 1. Gleichstromtechnik und Elektromagnetisches Feld. Ein Lehr- und Arbeitsbuch fuer das Grundstudium

    Energy Technology Data Exchange (ETDEWEB)

    Weissgerber, Wilfried

    2013-05-01

    The book under consideration covers the basics and calculation methods of the direct current technology as well as the electromagnetic field. The main topics are: fundamental concepts of physics, direct current technology, electric circuit, network calculation, energy and power, electromagnetic field, electric flow field, electrostatic and magnetic fields, induction, magnetic energy. The book is dedicated to the students of engineering and natural sciences, electrical engineering, technical informatics and physics at higher institutes of applied sciences, technical colleges, universities and universities of cooperative education.

  18. Modern power converter drives. Drive systems, power electronics, machines, mechatronics and motion control. 5. rev. and enl. ed.; Moderne Stromrichterantriebe. Antriebssystem, Leistungselektronik, Maschinen, Mechatronik und Motion Control, Arbeitsweise drehzahlveraenderbarer Antriebe mit Stromrichtern und Antriebsvernetzung

    Energy Technology Data Exchange (ETDEWEB)

    Brosch, P.F.

    2008-07-01

    This book informs students and practicians on variable-speed drives. Constructional engineers, technicians and others are given a practical tool for their daily work. - Fundamentals of motive power engineering - power converter components - electric machines - power converter drives with commutator motors - power converter drives with induction machines - integrated drive systems - motion control and mechatronics - selection and dimensioning of variable-speed drives converter measuring engineering - electromagnetic compatibility, with examples - measurements on power converter drives with variable speed adjustment - electromagnetic compatibility. (orig./GL)

  19. Electromagnetic converters and sensors. Fundamentals, fieldnumerical calculation of electromagnetic fields and application in mechatronics. 2. new rev. and enl. ed.; Elektromagnetische Wandler und Sensoren. Grundlagen, feldnumerische Berechnung elektromagnetischer Felder und Anwendungen in der Mechatronik

    Energy Technology Data Exchange (ETDEWEB)

    Cassing, W.; Stanek, W.; Erd, L.; Huebner, K.D.; Koch, J.; Dukart, A.

    2002-07-01

    Electrodynamic theories and calculation methods are discussed with particular regard to permanent electromagnetic circuits in mechatronics. Design strategies and computer calculation methods are explained by examples and applied to magnetic sensors, e.g. in automotive, electrically switched permanent magnet systems and actuators. The theoretical background is based primarily on the complete Maxwell's equations with their interdisciplinary related fields and up to compact formulations for use in relativistic quantum electrodynamics. [German] In diesem Fachbuch werden elektrodynamische Theorien und verschiedene Berechnungsverfahren unter besonderer Beruecksichtigung dauerelektromagnetischer Kreise in der Mechatronik behandelt. An ausgewaehlten Berechnungsbeispielen werden die wichtigsten Entwurfsstrategien und computerorientierten Rechenverfahren erlaeutert und auf magnetische Sensoren u.a. aus dem Bereich Automotive, elektrisch schaltbare Dauermagnetsysteme und Aktuatoren angewendet. Der theoretische Hintergrund hierfuer sind vorrangig die kompletten Maxwell'schen Gleichungen mit interdisziplinaeren Nachbargebieten bis hin zu kompakten Formulierungen fuer die relativistische Quantenelektrodynamik. (orig.)

  20. FEM. Fundamentals and applications of Finite-Element-Method in the field of machine- and vehicle engineering. 7. rev. ed.; FEM. Grundlagen und Anwendungen der Finite-Element-Methode im Maschinen- und Fahrzeugbau

    Energy Technology Data Exchange (ETDEWEB)

    Klein, B. [Kassel Univ. (Germany). Leichbau, CAD und Entwicklungsmethodik

    2007-07-01

    Virtual product development at the workstation has become reality, creating a link between 3D-CAD, MKS, FEM, STRUOPT and Rapid Prototyping. Engineers must have good knowledge of computer-assisted techniques. The key element of CAE is the finite element method (FEM) which is a universal analytical tool providing deep insight into the elastic, dynamic, cinematic/kinetic, thermal, and fluid-mechanical characteristics of components and systems. On the basis of these simulations, reliable predictions are possible that will shorten innovation and trial periods and result in very short amortisation periods of FEM investments. This is shown by the textbook in a very clear and illustrative manner. Case studies are presented to enable the reader to deepen her knowledge by herself. (orig.)

  1. The pellet wood gasification boiler - a modern and environment-friendly alternative for energy generation in the residential section. 3. rev. ed; Scheitholzvergaserkessel - eine moderne und umweltfreundliche Alternative fuer die Energieerzeugung im haeuslichen Bereich

    Energy Technology Data Exchange (ETDEWEB)

    Uth, J.

    2001-12-01

    The decision to install a pellet wood gasification boiler is a conscious vote using renewable fuels in the residential sector. This brochure has been elaborated to facilitate interested citizens the right selection of this boilers. So an effective evaluation of the listed boiler types is possible. Text and tables are based on a manufacturers questionnaire, taking place from 1995 to September 1999respectively in October 2000 due to a fast technological development were actualized. Furthermore new sellers appeared upgrading their product spectra in the heating sector by advanced wood gasification boilers.(GL) [German] Die Entscheidung zur Installation eines Scheitholzvergaserkessels ist ein bewusstes Votum zum Einsatz eines nachwachsenden Brennstoffes im haeuslichen Bereich. Um ineressierten Buergern die Auswahl geeigneter Kessel zu erleichtern, wurde die vorliegende Broschuere ausgearbeitet. Damit ist eine effektive Beurteilung der aufgelisteten Kesseltypen moeglich. Text und Tabellen basieren auf einer Herstellerumfrage aus dem Jahr 1995, die im September 1999 bzw. im Oktober 2000 auf grund der rasanten technischen Entwicklung dieses Sektors aktualisiert werden musste. Darueber hinaus sind gaenzlich neue Anbieter aufgetreten, die ihre Produktpalette im Heizungsbereich mit modernen Scheitholzvergaserkesseln aufwerten wollen (Pflege des ''Oekoimage'').(orig/GL)

  2. Unbundling and regulation in the German power industry. Practical manual for application of the EnWG. 3. rev. ed.; Entflechtung und Regulierung in der deutschen Energiewirtschaft. Praxishandbuch zum Energiewirtschaftsgesetz

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    The book provides a fast outline into the new legal boundary conditions for power supply in Germany. Apart from the legal aspects of power generation and distribution, other fields like taxes, labour, public procurement and cartel law are gone into as well. Subjects: Fundamentals, methods and current modifications of unbundling; Relevant aspects of unbundling for operators of transmission lines, grids, and power stores; Regulation by incentives and grid usage fees; Competences of state regulation authorities; Grid development planning. There is also a free online access to tools and updates. (orig./RHM)

  3. German legislation for promotion of renewable energies 2014. Act on feed-in and guaranteed pricing of electricity from renewable energy sources (EEG). Commentary. 7. new rev. ed.; Erneuerbare-Energien-Gesetz 2014. Gesetz fuer den Ausbau erneuerbarer Energien. Kommentar

    Energy Technology Data Exchange (ETDEWEB)

    Salje, Peter [Hannover Univ. (Germany). Lehrstuhl fuer Zivilrecht und Recht der Wirtschaft

    2015-07-01

    The EEG is continuously subjected to changes and the permanent center of political discussions. Therefore now already the 7th edition of the EEG comment of the science and practice well recognized and highly recognized author Prof. Dr. Dr. Peter Salje appear. The revision includes, inter alia, further evaluation of the law of electric power produced from renewable energy sources from the EEG of 2012 and the regulations made there under (including Biomass and AusglMechV). The changes associated with the so-called Photovoltaic amendment dated August 2012 and the recent case law since the publication of the previous edition handed down are considered. In particular, the incorporation of the full basic EEG reform in 2014 guarantees the highest topicality. [German] Das EEG ist fortlaufend Neuerungen unterworfen und im staendigen Mittelpunkt der politischen Diskussionen. In nunmehr bereits 7. Auflage erscheint daher der EEG-Kommentar von dem in Wissenschaft und Praxis bestens ausgewiesenen und hoechst anerkannten Autor Prof. Dr. Dr. Peter Salje. Die Neubearbeitung umfasst u.a. die weitere Auswertung des Rechts der Stromerzeugung aus Erneuerbaren Energien aus dem EEG 2012 und den dazu ergangenen Verordnungen (u.a. BiomasseV und AusglMechV). Die mit der sog. Photovoltaik-Novelle vom August 2012 einhergehenden Aenderungen sowie die seit Erscheinen der Vorauflage ergangene Rechtsprechung werden beruecksichtigt. Insbesondere die vollumfaengliche Einarbeitung der grundlegenden EEG-Reform 2014 garantiert hoechste Aktualitaet.

  4. Clinical neuroanatomy and diagnostic imaging and evaluation of the brain. MRI and CT atlas. 3. new rev. and enl. ed.; Klinische Neuroanatomie und kranielle Bilddiagnostik. Atlas der Magnetresonanztomographie und Computertomographie

    Energy Technology Data Exchange (ETDEWEB)

    Kretschmann, H.J. [Medizinische Hochschule Hannover (Germany); Weinrich, W. [Krankenhaus Nordstadt, Klinikum Hannover (Germany)

    2003-07-01

    New features of this 3rd German edition are: - Number of the MR and CT images almost doubled, all pictures now in large format, displaying much more brain structures. - New knowledge and insight incorporated in the text and pictures. (orig./CB) [German] In der vorliegenden 3. Auflage wurden die MR- und CT-Bilder des Bildatlas durch grossformatige Abbildungen ersetzt. Ihre Anzahl wurde nahezu verdoppelt. In den nun grossen Abbildungen konnte die Zahl der bezeichneten Hirnstrukturen wesentlich erhoeht werden. Neues Wissen wurde in den Text und in die Abbildungen aufgenommen. (orig./AJ)

  5. Blowers in practice. A manual for planners, constructors, and vocational training. 4. rev. and act. ed.; Ventilatoren in der Praxis. Das Handbuch fuer Planer, Anlagenbauer, Meister-, Techniker- und Ingenieurschulen

    Energy Technology Data Exchange (ETDEWEB)

    Lexis, J.

    2000-07-01

    The different specific properties and applications of radial blowers with and without casings, axial flow and cross-fow blowers are described with the aid of examples, comparisons and calculations. The book takes a practical attitude, i.e. theoretical elements like dimensionless characteristics are left out. The subject matter has been revised in consideration of the European standards (''EN''). [German] Dieses Handbuch dient dem planenden wie ausfuehrenden Lueftungs- und Klimaingenieur zur Loesung von ventilatortechnischen Problemstellungen. In einer praxisnahen Form sollen mit Hilfe von konkreten Beispielen, Gegenueberstellungen und Berechnungen die unterschiedlichen spezifischen Eigenschaften und Anwendungsgebiete von Radialventilatoren mit Gehaeuse, Radialventilatoren ohne Gehaeuse, Axial- und Querstromventilatoren aufgezeigt werden. Diese unterschiedlichen spezifischen Eigenschaften sind jedoch haeufig infolge zu theoretischer Behandlung dieser Thematik fuer den Klimaingenieur nicht leicht durchschaubar und bleiben daher vielfach unberuecksichtigt. Es wurde daher ganz bewusst auf die ansonsten in der Fachliteratur uebliche praxisfremde Darstellungsform dimensionsloser Kennlinien verzichtet. Vielen wertvollen Anregungen und Verbesserungsvorschlaegen folgend, wurden unter Beruecksichtigung der Europaeischen Normen ''EN'', die einzelnen Kapitel ergaenzt und ueberarbeitet. (orig.)

  6. Food guide: Constituents, additives, residues. Vol. 1. Fruit, vegetables, cereals, bread, biscuits, cakes and pastries, honey, sweets. 2. rev. ed.; Lebensmittelfuehrer: Inhalte, Zusaetze, Rueckstaende. Bd. 1. Obst, Gemuese, Getreide, Brot, Gebaeck, Knabberartikel, Honig, Suesswaren

    Energy Technology Data Exchange (ETDEWEB)

    Vollmer, G.; Josst, G.; Schenker, D.; Sturm, W.; Vreden, N.

    2001-07-01

    It is not easy for the consumer to select the right food. Supermarket displays, packaging or an attractive appearance may induce him to buy without reflecting. Food labels often present more problems than they propose to solve. Knowledge about food constituents is the best way to select food. Once the consumer knows what is inside food, and which of these substances are classified substances, it is easier for him to select the best food for his purposes and needs. The book therefore classifies fruit, vegetables, peas and beans potatoes and mushrooms, cereals, cakes and biscuits, sugar, chocolate, sweets, icecream, honey, marmalades, jellies and new foods according to their constituents. This includes nutrients (proteins, carbohydrates, fats, vitamins, minerals, roughage), additives (listed and unlisted), pollutants (natural, environmental and synthetic pollutants). The nature and function of the ingredients are explained in an introductory chapter. Agricultural and chemical production processes are discussed, and the range of products available on the market is listed alphabetically by groups of products or trade classes. Each chapter also contains information and practical household hints. [German] Aus der Fuelle des Lebensmittelangebots das Richtige auszuwaehlen, ist nicht leicht. Die Plazierung in den Regalen der Supermaerkte, die Verpackung oder das aeussere Erscheinungsbild verleiten den Verbraucher oft zu einem unueberlegten Einkauf. Auch die Kennzeichnung von Lebensmitteln gibt haeufig mehr Probleme auf, als dass sie Klarheit schafft. Am verlaesslichsten ist eine Beurteilung von Lebensmitteln anhand ihrer Inhaltsstoffe. Kennt sie der Verbraucher und weiss er, welche davon (nicht) kennzeichnungspflichtig sind, kann er sich leichter orientieren und besser nach seinen Beduerfnissen auswaehlen. In diesem Band werden deshalb Obst, Gemuese und Huelsenfruechte, Kartoffeln und Pilze, Getreide, Backwaren und Knabbererzeugnisse, Zucker, Schokolade, Zuckerwaren, Speiseeis, Honig, Konfituere, andere suesse Brotaufstriche und neuartige Lebensmittel nach ihren Inhaltsstoffen bewertet. Dabei sind die Inhalts- und Naehrstoffe (Eiweiss, Kohlenhydrate, Fette, Vitamine, Mineralstoffe, Ballaststoffe) der jeweiligen Lebensmittel, die (nicht) zugelassenen Zusatzstoffe und die moeglicherweise enthaltenen Schadstoffe (natuerliche Schadstoffe oder umweltbedingte wie Schwermetalle und synthetische wie Pflanzenbehandlungsmittel) angegeben und ihre Bedeutung am Anfang des Buches in einem einfuehrenden Kapitel erlaeutert. Des weiteren gibt der Band Auskunft ueber Anbaumethoden beziehungsweise Herstellungsverfahren sowie ueber das Warensortiment des Handels (eingeteilt nach Warengruppen oder Handelsklassen bzw. alphabetisch geordnet). Informationen und praktische Hinweise fuer den Haushalt runden die einzelnen Kapitel ab. (orig.)

  7. Physics, radiology, and chemistry. An introduction to natural science. Textbook for the medical professions and nursing training centres. 7. rev. ed. Physik, Strahlenkunde und Chemie. Eine Einfuehrung in diese Naturwissenschaften. Studienbuch fuer Angehoerige der Heilberufe und Krankenpflegeschulen

    Energy Technology Data Exchange (ETDEWEB)

    Linde, O.K.; Knigge, H.J.

    1986-01-01

    This book is an introduction to physics and chemistry especially for medical personnel. After a general introduction, measurement methods, mechanics including mechanics of solid bodies, fluids and gases, heat, optics, acoustics, electricity, radiations including their biological effects, general chemistry, inorganic and organic chemistry are treated. Every chapter contains exercises mostly in connection with medical and biological effects. Furthermore, connections with biology and medicine are considered. The chapters on physiological chemistry, computer and information theory, chemistry and ecology, and metabolism have been rewritten. (HP).

  8. Physics, radiology, and chemistry. An introduction to natural science. Textbook for the medical professions and nursing training centres. 8. rev. ed. Physik, Strahlenkunde und Chemie. Eine Einfuehrung in diese Naturwissenschaften. Studienbuch fuer Angehoerige der Heilberufe und Krankenpflegeschulen

    Energy Technology Data Exchange (ETDEWEB)

    Linde, O.K.; Knigge, H.J.

    1991-01-01

    This book is an introduction to physics and chemistry especially for medical personnel. After a general introduction, measurement methods, mechanics including mechanics of solid bodies, fluids and gases, heat, optics, acoustics, electricity, radiations including their biological effects, general chemistry, inorganic and organic chemistry are treated. Every chapter contains exercises mostly in connection with medical and biological effects. Furthermore connections with biology and medicine are considered. (orig./HP) With 104 figs., 51 tabs.

  9. The billet wood gasification boiler - a modern and environment-friendly alternative for energy generation in the residential section. 2. rev. ed.; Scheitholzvergaserkessel - eine moderne und umweltfreundliche Alternative fuer die Energieerzeugung im haeuslichen Bereich

    Energy Technology Data Exchange (ETDEWEB)

    Uth, J.

    2000-10-15

    The decision to install a billet wood gasification boiler is a conscious vote using renewable fuels in the residential sector. This brochure has been elaborated to facilitate interrested citizens the right selection of this boilers. So an effective evaluation of the listed boiler types is possible. Text and tables are based on a manufacturers questionnaire, taking place from 1995 to September 1999respectively in October 2000 due to a fast technological development were actualized. Furthermore new sellers appeared upgrading their product spectra in the heating sector by advanced wood gasification boilers.(GL) [German] Die Entscheidung zur Installation eines Scheitholzvergaserkessels ist ein bewusstes Votum zum Einsatz eines nachwachsenden Brennstoffes im haeuslichen Bereich. Um ineressierten Buergern die Auswahl geeigneter Kessel zu erleichtern, wurde die vorliegende Broschuere ausgearbeitet. Damit ist eine effektive Beurteilung der aufgelisteten Kesseltypen moeglich. Text und Tabellen basieren auf einer Herstellerumfrage aus dem Jahr 1995, die im September 1999 bzw. im Oktober 2000 auf grund der rasanten technischen Entwicklung dieses Sektors aktualisiert werden musste. Darueber hinaus sind gaenzlich neue Anbieter aufgetreten, die ihre Produktpalette im Heizungsbereich mit modernen Scheitholzvergaserkesseln aufwerten wollen (Pflege des ''Oekoimage'').(orig/GL)

  10. Endogenous rhythmicity of Bmal1 and Rev-erb alpha in the hamster pineal gland is not driven by norepinephrine.

    Science.gov (United States)

    Wongchitrat, Prapimpun; Felder-Schmittbuhl, Marie-Paule; Phansuwan-Pujito, Pansiri; Pévet, Paul; Simonneaux, Valérie

    2009-05-01

    Pineal melatonin is synthesized with daily and seasonal rhythms following the hypothalamic clock-driven release of norepinephrine (NE). The pineal gland of rats and mice, like the biological clock, expresses a number of clock genes. However, the role of pineal clock elements in pineal physiology is still unknown. We examined the expression and regulation of several clock genes (Per1, Cry2, Bmal1 and Rev-erb alpha) under different lighting conditions or following adrenergic treatments in the Syrian hamster, a seasonal rodent. We found that Per1 and Cry2 genes were similarly regulated by the nocturnal release of NE: levels of Per1 and Cry2 mRNA displayed a nocturnal increase that was maintained after 2 days in constant darkness (DD) but abolished after 2 days under constant light (LL), a condition that suppresses endogenous NE release, or after an early night administration of the adrenergic antagonist propranolol. In contrast, Bmal1 and Rev-erb alpha exhibited a different pattern of expression and regulation. mRNA levels of both clock genes displayed a marked daily variation, maintained in DD, with higher values at midday for Bmal1 and at day/night transition for Rev-erb alpha. Remarkably, the daily variation of both Bmal1 and Rev-erb alpha mRNA was maintained in LL conditions and was not affected by propranolol. This study confirms the daily regulation of Per1 and Cry2 gene expression by NE in the pineal gland of rodents and shows for the first time that a second set of clock genes, Bmal1 and Rev-erb alpha are expressed with a circadian rhythm independent of the hypothalamic clock-driven noradrenergic signal.

  11. RT-PCR Analysis of ED-A,ED-B, and IIICS Fibronectin Domains: A New Screening Marker For Bladder Cancer

    Directory of Open Access Journals (Sweden)

    M Ahmadi Javid

    2004-12-01

    Full Text Available Background: Fibronectin seems to play a very important role in the progression and invasion of bladder cancer. EDA, EDB, and IIICS domains of fibronectin are not expressed in the adult persons but they’re expressed in different cancers. The aim of this study is to investigate the mRNA of fibronectin in transitional carcinoma cells (TCC of bladder to study these domains. Methods: A total of 20 patients with known bladder cancer were studied. Two of them excluded since their excised tissues were not enough for both the pathological examination and RNA study. Another 20 (control group were normal volunteers who needed bladder operations. The excised tissue was immediately transferred to RNAlater (Ambion,TX. RNA was extracted via RNAWIZ (Ambion, TX. cDNA was made via RevertAid First Strand cDNA Synthesis Kit (Fermentas. PCR of the cDNAs was performed using primers for EDA, EDB, and IIICS (Eurogentec,Belgium. Results: For the first time, we present the expression of the oncofetal fibronectin mRNA in the transitional cell carcinoma of bladder. The high grade muscle invasive (G3T2 tumor, expressed ED-A, ED-B, and IIICS. Expression of ED-A, ED-B, and IIICS was confirmed in the two patients with G3T1 TCC. The four patients with G2Ta and G3Ta expressed both ED-A and ED-B. The four patients with G1T1 tumor expressed ED-A only, similar to the nine patients with G1Ta tumor. None of the normal volunteers expressed the oncofetal extra domains. The sensitivity of ED-A positive fibronectin RNA for detecting TCC of any kind is 100%, and of ED-B was only 35%. The specificity of ED-B positive fibronectin RNA for the high grade TCC is 100%. Conclusion: ED-A, ED-B, and IIICS could be used as useful markers for the diagnosis and following up of bladder carcinoma. Keywords: Transitional Cell Carcinoma, bladder cancer, fibronectin, RT-PCR, oncofetal.

  12. Patient-Centered Care Transition for Patients Admitted through the ED: Improving Patient and Employee Experience

    Directory of Open Access Journals (Sweden)

    Andrea Algauer BSN, RN

    2015-05-01

    Full Text Available With increasing wait times in emergency departments (ED across America, there is a need to streamline the inpatient admission process in order to decrease wait times and more important, to increase patient and employee satisfaction. One inpatient unit at New York-Presbyterian Weill Cornell Medical Center initiated a program to help expedite the inpatient admission process from the ED. The goal of the ED Bridge program is to ease the patient's transition from the ED to an inpatient unit by visiting the patient in the ED and introducing and setting expectations for the inpatient environment (i.e. telemetry alarms, roommates, hourly comfort rounds. Along with improving the patient experience, this program intends to improve the collaboration between ED nurses and inpatient nurses. With the continued support of our nurse management, hospital administrators and most important, our staff, this concept is aimed to increase patient satisfaction scores and subsequently employee satisfaction.

  13. The NStED Periodogram Service and Interface for Public CoRoT Data

    CERN Document Server

    von Braun, K; Beekley, A; Berriman, G B; Bryden, G; Chan, B; Ciardi, D R; Good, J; Harbut, M; Kane, S R; Laity, A; Lau, C; Lynn, M; McElroy, D; Plavchan, P; Regelson, M; Rey, R; Ramirez, S V; Stauffer, J; Zhang, A

    2011-01-01

    As part of the NASA-CNES agreement, the NASA Star and Exoplanet Database (NStED) serves as the official US portal for the public CoRoT data products. NStED is a general purpose archive with the aim of providing support for NASA's planet finding and characterization goals. Consequently, the NASA Exoplanet Science Institute (NExScI) developed, and NStED adapted, a periodogram service for CoRoT data to determine periods of variability phenomena and create phased photometric light curves. Through the NStED periodogram interface, the user may choose three different period detection algorithms to use on any photometric time series product, or even upload and analyze their own data. Additionally, the NStED periodogram is remotely accessed by the CoRoT archive as part of its interface. NStED is available at {\\bf http://nsted.ipac.caltech.edu}.

  14. Effect of Layered Double Hydroxides on Ultraviolet Aging Resistance of SBS Modifi ed Bitumen Membrane

    Institute of Scientific and Technical Information of China (English)

    XU Song; YU Jianying; XUE Lihui; SUN Yubin; XIE Dong

    2015-01-01

    Layered double hydroxides (LDHs)/styrene-butadiene-styrene (SBS) copolymer modified bitumen was prepared by melt blending. The effect of LDHs on the ultraviolet (UV) aging behavior of SBS modifi ed bitumen was investigated. The changes of chemical structures of modifi ed bitumen before and after UV aging were characterized by Fourier transform infrared spectroscopy (FTIR). The results show that LDHs obviously reduce the variation of softening point and low temperaturefl exibility of SBS modifi ed bitumen under different UV radiation intensities, which indicates that the UV aging resistance performance of SBS modifi ed bitumen is improved effectively by LDHs. Compared with SBS modifi ed bitumen, the changes of carbonyl, sulfoxide and butadienyl of LDHs/SBS modified bitumen decrease significantly after UV aging according to FTIR analysis, demonstrating that the oxidation and degradation reactions of SBS modifi ed bitumen were restrained effectively by adding LDHs.

  15. Are family physicians the answer to ED doctor shortage, or 'blasphemy'?

    Science.gov (United States)

    2011-01-01

    Some organizations maintain that family physicians have the skills and training necessary to practice in the ED and help combat the current physician shortage, while others maintain their training is inadequate. Here are some issues to take into consideration with such candidates: Have they obtained thorough experience the necessary skills to practice in the ED? Have they received a significant amount of clinical training in an ED? Has their training progress been monitored by a teaching attending?

  16. Horns Rev offshore wind power farm. Environmental impact assessment on water quality

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, Per

    2000-05-15

    As part of an overall Environmental Impact Assessment (EIA) undertaken in connection with a planned 150 MW offshore wind farm at Horns Rev, an assessment was made of the effects the wind farm would have on the water quality in the area. This EIA study was drawn up in accordance with the guidelines laid down by the Danish Ministry of Environment and Energy in the publication 'Guidelines for the preparation of EIA studies for offshore wind farms'. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. Only local and minor changes are anticipated in connection with the currents, sediments and wave conditions during the production phase. These will occur in the immediate vicinity of the individual foundations. For these reasons, no changes are expected in the water quality. This also includes also the pelagic primary production and the occurrence of plankton in the area. Increased local copper contamination of phytoplankton and zooplankton may be expected during the production phase, as a result of the total annual discharge of 206 kg copper from the slip-rings in the wind turbines. The contamination will potentially result in a local reduction of the pelagic primary production and changes in the species composition of the plankton. The wind turbines will be sandblasted and painted once during their lifetime, as part of the routine maintenance. The sandblasting and painting will lead to a temporary spill of paint, paint waste and sand. The impacts on water quality and plankton production are unknown. It is recommended that factors such as the toxicity of the paint be investigated, and that spills and the impact of waste be reduced as much as possible. The water quality and the plankton in the wind farm area and along the cable line's passage to shore through the international protected area, will only be

  17. Design of octahedral spherical hohlraum for CH Rev5 ignition capsule

    Science.gov (United States)

    Cao, Hui; Chen, Yao-Hua; Zhai, Chuanlei; Zheng, Chunyang; Lan, Ke

    2017-08-01

    In this paper, we design an octahedral spherical Au hohlraum for CH Rev5 ignition capsule [S. W. Haan et al., Phys. Plasmas 18, 051001 (2011)] by using the initial design method and two-dimensional (2D) simulations, and we investigate its laser entrance hole (LEH) closure and laser-plasma instabilities (LPI) by using a spherical hohlraum with two different-size LEHs via 2D simulations. The designed spherical hohlraum with RH=5 RC, RL=1.2 mm , and RL*=2 RL requires an ignition laser pulse of 1.92 MJ in energy and 670 TW in peak power, where RH, RC, RL, and RL* are radii of the spherical hohlraum, capsule, LEH, and the cylindrical LEH outer ring, respectively. From 2D simulations, the closure and opening up of LEH are clearly obtained. The LEH closure and its rate are strongly connected to the radiation pulse, while the LEH opening-up and its rate are strongly connected to the laser pulse. The smallest radius of LEH during closure is 0.6 mm before opening up, which leaves enough room for arranging the laser beams with a radius of 0.5 mm in our design. By using a post-process code for LPI, a relatively high stimulated Brillouin scattering fraction and a very low stimulated Raman scattering fraction are predicted, which may be due to the neglection of three-dimensional density gradients of the ablative flow along the laser transportation in 2D simulations. This work provides the energy and power references for the future ignition laser facility which uses octahedral spherical hohlraums as ignition targets.

  18. HRensembleHR. High resolution ensemble for Horns Rev. Final project report; Offshore wind power

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The wind farm output of an offshore-farm such as Horns Rev changes between nearly constant output to highly variable power output. A balance responsible will therefore benefit from knowing the variability of a wind farm in advance. Some understanding of the observed variability and the corresponding forecast error on offshore wind farms had been gathered in the past few years, while a large fraction (about 60%) of the error still lacked understanding and required further intense research. This was the outset at the beginning of the HREnsemble project. Results from the wave study, variability study, ocean coupling, findings from the sensitivity experiments, the iEnKF short-term forecast and finally the demonstration phase have given significant synergy. The most basic research result in the project is that the two empirical mode decomposition approaches, Hilbert-Huang and later the Ensemble Empirical Mode Decomposition (EEMD). Both approaches confirmed that significant variability exists in offshore conditions. It was found that the variability of the short time-scales (24 minutes) are either not explicitly visible in the grid-scale of the NWP models or in the best case significantly smoothed out in all of the tested model configurations. If we interpret 2/3 of the variability due to vertical waves not present in the mean flow and 1/3 of the variability due to meso-scale weather, then the model results and EEMD are consistent. We can however not verify this theory. At present we do not know if EEMD counts neither the events correct nor whether the ensemble forecast suppresses variability. The existence of variability above the time-scale related to friction between ocean waves and air can in fact explain some of the inconsistent results published in the literature and set a question mark behind the correctness of the calculation of friction in wave, ocean and weather modelling. (LN)

  19. Mapping Wind Farm Loads and Power Production - A Case Study on Horns Rev 1

    Science.gov (United States)

    Galinos, Christos; Dimitrov, Nikolay; Larsen, Torben J.; Natarajan, Anand; Hansen, Kurt S.

    2016-09-01

    This paper describes the development of a wind turbine (WT) component lifetime fatigue load variation map within an offshore wind farm. A case study on the offshore wind farm Horns Rev I is conducted with this purpose, by quantifying wake effects using the Dynamic Wake Meandering (DWM) method, which has previously been validated based on CFD, Lidar and full scale load measurements. Fully coupled aeroelastic load simulations using turbulent wind conditions are conducted for all wind directions and mean wind speeds between cut-in and cut-out using site specific turbulence level measurements. Based on the mean wind speed and direction distribution, the representative 20-year lifetime fatigue loads are calculated. It is found that the heaviest loaded WT is not the same when looking at blade root, tower top or tower base components. The blade loads are mainly dominated by the wake situations above rated wind speed and the highest loaded blades are in the easternmost row as the dominating wind direction is from West. Regarding the tower components, the highest loaded WTs are also located towards the eastern central location. The turbines with highest power production are, not surprisingly, the ones facing a free sector towards west and south. The power production results of few turbines are compared with SCADA data. The results of this paper are expected to have significance for operation and maintenance planning, where the schedules for inspection and service activities can be adjusted to the requirements arising from the varying fatigue levels. Furthermore, the results can be used in the context of remaining fatigue lifetime assessment and planning of decommissioning.

  20. Administrative circulars No. 22A (rev. 1) – Award of additional periods of membership in the Pensions Fund for long-term shift work and No. 22B (rev. 1) – Compensation for long-term shift work hours

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circulars No. 22A (Rev. 1) entitled "Award of additional periods of membership in the Pension Fund for long-term shift work" and No. 22B (Rev.1) entitled “Compensation for long-term shift work hours”, adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 March 2011, are available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp They cancel and replace Administrative Circulars No. 22A and 22B entitled "Award of additional periods of membership in the Pension Fund to shift workers (Early Departure)” and “Duration and special compensation for shift work” of January 2000. This new version clarifies, in particular, the compensation of effective long-term shift work hours. Department Head Office  

  1. Resposta imunitária à vacinação conjuntival com a estirpe Rev.1 de Brucella melitensis em ovinos e caprinos Serological response of sheep and goats to conjunctival Brucella melitensis Rev.1 vaccine

    Directory of Open Access Journals (Sweden)

    P. Poeta

    2003-04-01

    Full Text Available The live B. melitensis Rev.1 strain is considered the best vaccine available for the prophylaxis of brucellosis in small ruminants, especially when used at the standard dose by the conjunctival route. In the present study a 1´ 10(9 CFU dose for both sheep and goats conjunctivally vaccinated was tested to evaluate the duration of serological responses. Conjunctival vaccination with Rev. 1 performed in adult animals induced a rapid rise in serological titres as measured by Rose Bengal Plate Test (RBPT, Complement Fixation Test (CF and Modified Rose Bengal Plate Test (MRBPT. Titres then decreased and became negative in most animals by four months after vaccination (except MRBPT. The goats responded better to the vaccination than the sheep as one month after vaccination 100% of the goats revealed positive results to RB and RBM and 93.4% to FC test. The RBM was the one that detected more positive animals along the study.

  2. RevMan、Stata和R软件在生存资料Meta分析的应用%The Application of RevMan, Stata and R Software for Meta-analysis of Survival Data

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    生存资料的Meta分析越来越多.从原始文献计算出风险比(HR)及其95%可信区间,实际频数和理论频数的差值(O-E)及其标准差后,可以使用Review Manager (RevMan)、Stata和R等软件计算合并HR.RevMan软件简单易学,但存在一定的局限;Stata和R软件功能强大,灵活多样,能够绘制多种图形,但需要进行适当的编程.

  3. 无对照二分类数据的Meta分析在RevMan软件中的实现%Implement Meta-Analysis with Non-Comparative Binary Data in RevMan Software

    Institute of Scientific and Technical Information of China (English)

    陈月红; 杜亮; 耿兴远; 刘关键

    2014-01-01

    本文介绍无对照二分类数据资料的2种效应指标及其标准误的计算方法,然后通过1个实例分别用上述2种方法计算效应指标及其标准误,将计算所得的效应指标及其标准误在RevMan软件中进行Meta分析,最后将计算结果与用实例的原始数据在Stata软件中的Meta分析结果进行比较.结果显示RevMan和Stata软件进行无对照二分类数据资料Meta分析的结果一致.

  4. Spazio, movimento, prospettiva ed empatia: un prototipo di videogame didattico

    Directory of Open Access Journals (Sweden)

    Pio Alfredo Di Tore

    2014-09-01

    Full Text Available Questo lavoro presenta la cornice teorica che sta alla base della progettazione di un videogame didattico pensato per valutare le abilità di perspective taking (capacità di adottare la prospettiva altrui e di mental rotation (rotazione mentale dei giocatori. Lo studio mira a rilevare come tali abilità siano coinvolte nella relazione empatica e a verificarne le implicazioni in campo educativo. Il lavoro adotta la definizione di empatia riconducibile ad Alain Berthoz ed alla teoria spaziale dell’empatia qui presentata con i relativi sistemi di riferimento spaziale. È inoltre fornita una rapida revisione della letteratura sulla rappresentazione dello spazio nel bambino e sulla rappresentazione dello spazio nel gioco (su base visiva. Infine, il lavoro descrive il prototipo di gioco – realizzato presso l’Università di Salerno – in cui il giocatore si trova alle prese con tre differenti compiti di cui due progettati per misurare le abilità di perspective taking mentre il terzo è calibrato sulle abilità di mental rotation.

  5. Etica ed evoluzionismo: la proposta di Marc Hauser

    Directory of Open Access Journals (Sweden)

    Irene Pilloni

    2013-11-01

    Full Text Available Le recenti scoperte nell’ambito della psicologia evoluzionistica potrebbero offrire una risposta al dibattito sull’origine evoluzionistica della facoltà morale dell’Homo sapiens. In passato, il tentativo di spiegare il comportamento morale a partire dalla teoria dell’evoluzione è stato intrapreso dal padre fondatore dell’evoluzionismo Charles Darwin, successivamente da T.H. Huxley e da H. Spencer e infine dal sociobiologo E. Wilson a metà degli anni ‘70 del Novecento. Oggi questa impresa è stata ereditata dallo psicologo evoluzionista Marc Hauser, le cui indagini prendono avvio da un’analogia tra facoltà morale e facoltà linguistica. Questa analogia gli consente di affermare che la pluralità di codici morali adottati dagli uomini nelle differenti culture dipende da un numero limitato di principi morali, nello stesso modo in cui la varietà di lingue con cui gli uomini si esprimono, dipende da un numero limitato di principi linguistici universali. Dunque, sembrerebbe che l’evoluzione biologica abbia plasmato dei principi morali universali e uniformi che si presentano costanti in tutti gli uomini a prescindere dalla loro appartenenza culturale. Come vadano intesi i principi morali universali e quale rapporto intercorre tra di essi e i vari codici morali sarà l’argomento di questo saggio, il quale tenterà di analizzare la proposta di Marc Hauser all’interno della cornice dei rapporti tra etica ed evoluzionismo.

  6. Interdisciplinary mistrust, communication breakdowns cited in survey of ED handoffs.

    Science.gov (United States)

    2015-11-01

    Both emergency and inpatient physicians agree that miscommunication during interunit handoffs can compromise patient care and that sequential handoffs are particularly problematic, according to a new study conducted at the University of Nebraska Medical Center (UNMC) in Omaha, NE. The study highlights physician survey data showing that there is mistrust between inpatient and emergency physicians, and that which provider is responsible for patient care can be unclear when a verbal handoff is made. To make improvements, UNMC has been piloting a tool aimed at standardizing verbal and written handoff communications. Nearly a third of all the participating physicians surveyed reported having handoff-related adverse events, and most put the blame on ineffective communication. Ninety-four percent of emergency physicians surveyed indicated that they had to defend their clinical decisions at least some of the time. The admitting physicians largely validated this concern, with more than 25% noting that they usually disagree with decisions made in the ED. Using the situation, background, assessment, recommendation (SBAR) form of communication as a starting point, an intervention tool aims to streamline handoff communications, both verbally and in the electronic medical record.

  7. Book Review: Digital Forensic Evidence Examination (2nd ed.

    Directory of Open Access Journals (Sweden)

    Gary Kessler

    2010-06-01

    Full Text Available Cohen, F. (2010. Digital Forensic Evidence Examination (2nd ed.. Livermore, CA: ASP Press. 452 pages, ISBN: 978-1-878109-45-3, US$79.Reviewed by Gary C. Kessler, Gary Kessler Associates & Edith Cowan University (gck@garykessler.netOn the day that I sat down to start to write this review, the following e-mailcame across on one of my lists:Person A and Person B write back and forth and create an email thread. Person A then forwards the email to Person C, but changes some wording in the email exchange between A & B. What is the easiest way (and is it even possible to find out when that earlier email message was altered before sent to Person C?Before you try to answer these questions, read Fred Cohen's Digital Forensic Evidence Examination. His book won't actually tell you how to answer these questions but it will help you understand the difficulty in even trying to answer them with any level of certainty.(see PDF for full review

  8. Hearing of Mr. Francois Roussely, President of EdF; Audition de M. Francois Roussely, President d'EdF

    Energy Technology Data Exchange (ETDEWEB)

    Roussely, F. [Electricite de France (EDF), 75 - Paris (France)

    2005-07-01

    This document is the proceedings of the hearing of F. Roussely, President of Electricite de France (EdF), at the commission of economic affairs of the French house of commons, about the advisability of the construction of the EPR (European pressurized reactor) demonstration plant and about its possible financing by EdF. In a first part, F. Roussely recalls the European context of deregulation of energy markets and its impact of the French electric power industry (opening of the French market, industrial and social actions of EdF, need of a new generation of nuclear reactor, preservation of EdF's energy mix, warranty of public utility, un-bundling between energy trade and distribution, EdF's turnover and profitability, EdF's foreign daughter companies). In a second part, F. Roussely answers a series of questions asked by the different members of the commission concerning the different points presented in the first part. (J.S.)

  9. The utility of transvaginal ultrasound in the ED evaluation of complications of first trimester pregnancy.

    Science.gov (United States)

    Panebianco, Nova L; Shofer, Frances; Fields, J Matthew; Anderson, Kenton; Mangili, Alessandro; Matsuura, Asako C; Dean, Anthony J

    2015-06-01

    For patients with early intrauterine pregnancy (IUP), the sonographic signs of the gestation may be below the resolution of transabdominal ultrasound (TAU); however, it may be identified by transvaginal ultrasound (TVU). We sought to determine how often TVU performed in the emergency department (ED) reveals a viable IUP after a nondiagnostic ED TAU and the impact of ED TVU on patient length of stay (LOS). This was a retrospective cohort study of women presenting to our ED with complications of early pregnancy from January 1, 2007 to February 28, 2009 in a single urban adult ED. Abstractors recorded clinical and imaging data in a database. Patient imaging modality and results were recorded and compared with respect to ultrasound (US) findings and LOS. Of 2429 subjects identified, 795 required TVU as part of their care. Emergency department TVU was performed in 528 patients, and 267 went to radiology (RAD). Emergency department TVU identified a viable IUP in 261 patients (49.6%). Patients having initial ED US had shorter LOS than patients with initial RAD US (median 4.0 vs 6.0 hours; P < .001). Emergency department LOS was shorter for women who had ED TVU performed compared with those sent for RAD TVU regardless of the findings of the US (median 4.9 vs 6.7 hours; P < .001). There was no increased LOS for patients who needed further RAD US after an indeterminate ED TVU (7.0 vs 7.1 hours; P = .43). There was no difference in LOS for those who had a viable IUP confirmed on ED TAU vs ED (median 3.1 vs 3.2 hours, respectively; P < .32). When an ED TVU was performed, a viable IUP was detected 49.6% of the time. Emergency department LOS was significantly shorter for women who received ED TVU after indeterminate ED TAU compared with those sent to RAD for TVU, with more marked time savings among those with live IUP diagnosed on ED TVU. For patients who do not receive a definitive diagnosis of IUP on ED TVU, this approach does not result in increased LOS. Copyright © 2015

  10. ADMINISTRATIVE CIRCULAR No. 25 (REV. 3) - Special provisions for the fire and rescue service governing working and rest time

    CERN Document Server

    2012-01-01

    Administrative Circular No. 25 (Rev. 3) entitled “Special provisions for the Fire and Rescue Service governing working and rest time”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 28 September 2012 and entering into force in October 2012, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp This Circular is applicable to staff members of the Fire and Rescue Service It cancels and replaces Administrative Circular No. 25 (Rev. 2) entitled “Shift work – Special provisions for the Fire and Rescue Service” of April 2003. This new version takes into account the new organisation of the Fire and Rescue Service, members of which will henceforth not exclusively perform their functions in the context of shift work, but also during reference working hours and during stand-by duty. Additionally, applicable limits regarding working and rest times an...

  11. Reply Comments on Phys. Rev. D89, 097101 (2014) "Reevaluation of the parton distribution of strange quarks in the nucleon"

    CERN Document Server

    Aschenauer, E C; Joosten, S; Rith, K; Schnell, G; Van Hulse, C

    2015-01-01

    In the "Comments on Phys. Rev. D89, 097101 (2014)", the Author presents a number of studies to conjecture that the analysis by the HERMES Collaboration presented in Phys. Rev. D89, 097101 (2014) likely suffers from effects that invalidate the leading-order analysis used in that publication. In our opinion, the Author has drawn erroneous conclusions. We present below a discussion of his arguments and the results from a repetition of that analysis using a range of parton distribution sets. The spread in those results precludes credible conclusions and demonstrates the sensitivity of the analysis to poorly known input data (unfavored FFs, strange-quark distributions, and mixed singlet and nonsinglet quantities).

  12. Operational Circular No.2 (Rev. 2) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    2014-01-01

    Operational Circular No. 2 (Rev. 2) entitled “Conditions of access to the fenced parts of the CERN site” and its “implementation measures”, approved by the Director-General following discussion at the Standing Concertation Committee meeting on 20 May 2014 and entering into force on 1 September 2014, are available on the intranet site of the Human Resources Department (see here).   This circular is applicable to members of the personnel and other persons concerned. It cancels and replaces Operational Circular No. 2 (Rev. 1) entitled “Conditions of access to the fenced parts of the CERN site”, of April 1998. In particular, the revised circular provides for the possibility of mandating a person responsible for the proper implementation of the circular, specifies the rules relating to vehicles allowed on the site and the respective responsibilities of their owners, and relaxes certain administrative formalities in case of loss, theft or di...

  13. Operational Circular No. 2 (Rev. 3) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    HR Department

    2015-01-01

    Operational Circular No. 2 (Rev. 3) entitled "Conditions of access to the fenced parts of the CERN site", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 24 September 2015, is now available via this link.   This revised circular cancels and replaces Operational Circular No. 2 (Rev. 2) also entitled "Conditions of access to the fenced parts of the CERN site", of September 2014. The circular was revised predominantly in order to specify that access to the CERN site is granted to CERN Pension Fund beneficiaries only provided that they are actually in receipt of payments from the Fund; and to allow the Director-General to permit special types of vehicles on site, such as trailers. It also includes a certain number of text improvements and an updated version of the implementation measures, in particular with regard to vehicle identification, road traffic and parking.  

  14. Administrative circular n°3 (Rev. 2) – Home leave, travel to home station and assimilated leave and travel

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 3 (Rev. 2) entitled “Home leave, travel to the home station and assimilated leave and travel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to employed members of the personnel. It cancels and replaces Administrative Circular No. 3 (Rev. 1) entitled “Travel to the home station and home leave” of June 2002. The circular was revised in order to take into account the new status of Associate Member State and the fact that henceforth, home stations may be situated on territory outside of Europe. It is proposed to introduce a new system of determination of the benefits (Travel expenses, travel time and distance indemnity) granted in the context of home leave and supplementary journeys to the home station.  For t...

  15. LabINRS. Mesures en laboratoire du coefficient de frottement dynamique de revêtements de sol

    OpenAIRE

    Marchal, P.; Jacques, M.

    2014-01-01

    Le LabINRS est un banc d’essai de laboratoire destiné à mesurer le coefficient de frottement dynamique d’un revêtement de sol. Ce document décrit le protocole de mesures avec le LabINRS et les résultats de mesures effectuées sur un panel de quinze revêtements de sol de caractéristiques différentes (matériaux, états de surface) réalisées en présence de deux polluants (huile et solution d’eau). Le LabINRS présente une sensibilité élevée et une très bonne répétabilité. Ces résultats ont été comp...

  16. Final Report - Sulfate Solubility in RPP-WTP HLW Glasses, VSL-06R6780-1, Rev. 0

    Energy Technology Data Exchange (ETDEWEB)

    Kruger, Albert A.; Pegg, I. L.; Feng, A.; Gan, H.; Kot, W. K.

    2013-12-03

    This report describes the results of work and testing specified by Test Specifications 24590-HLW-TSP-RT-01-006 Rev 1, Test Plans VSL-02T7800-1 Rev 1 and Test Exceptions 24590-HLW-TEF-RT-05-00007. The work and any associated testing followed established quality assurance requirements and were conducted as authorized. The descriptions provided in this report are an accurate account of both the conduct of the work and the data collected. Results required by the Test Plans are reported. Also reported are any unusual or anomalous occurrences that are different from the starting hypotheses. The test results and this report have been reviewed and verified.

  17. A new Method to Estimate the Representative Elementary Volume (REV) for Porosity in Heterogeneous Karst Aquifers Using Geographic Information Systems

    Science.gov (United States)

    Gross, M. R.; Manda, A. K.

    2004-12-01

    Karst limestones are characterized by solution-enhanced macropores and conduits that lead to exceptional heterogeneity at the aquifer scale. The interconnected network of solution cavities often results in a conduit flow regime that bypasses the less permeable rock matrix. Efforts to manage and protect karst aquifers, which are vital water resources in many parts of the world, will benefit from meaningful characterizations of the heterogeneity inherent in these formations. To this end, we propose a new method to estimate the representative elementary volume (REV) for macroporosity within karst aquifers using techniques borrowed from remote sensing and geospatial analysis. The REV represents a sampling window in which numerous measurements of a highly-variable property (e.g., porosity, hydraulic conductivity) can be averaged into a single representative value of statistical and physical significance. High-resolution borehole images are classified into binary images consisting of pixels designated as either rock matrix or pore space. A two-dimensional porosity is calculated by summing the total area occupied by pores within a rectangular sampling window placed over the binary image. Small sampling windows quantify the heterogeneous nature of porosity distribution in the aquifer, whereas large windows provide an estimate of overall porosity. Applying this procedure to imagery taken from the Biscayne aquifer of south Florida yields a macroporosity of ~40%, considerably higher than the ~28% porosity measured from recovered core samples. Geospatial analysis may provide the more reliable estimate because it incorporates large solution cavities and conduits captured by the borehole image. The REV is estimated by varying the size of sampling windows around prominent conduits and evaluating the change in porosity as a function of window size. Average porosities decrease systematically with increasing sampling size, eventually converging to a constant value and thus

  18. Comment on "Total Negative Refraction in Real Crystals for Ballistic Electrons and Light" (Phys. Rev. Lett. 91, 157404 (2003))

    OpenAIRE

    Yau, H. -F.; Liu, J.-P.; Ke, B; Kuo, C. -H.; Ye, Z.

    2003-01-01

    Recently, Zhang et al. (Phys. Rev. Lett. 91, 157404 (2003)) have demonstrated that an amphoteric refraction, i. e. both positive and negative refraction, may prevail at the interface of two uniaxial anisotropic crystals when their optical axes are in different directions. The authors subsequently made a correspondence between such a refraction with the negative refraction expected for Left Handed Materials (LHMs). Here we comment that the amphoteric refraction can be observed even with one un...

  19. Nuclear receptor REV-ERBα mediates circadian sensitivity to mortality in murine vesicular stomatitis virus-induced encephalitis.

    Science.gov (United States)

    Gagnidze, Khatuna; Hajdarovic, Kaitlyn H; Moskalenko, Marina; Karatsoreos, Ilia N; McEwen, Bruce S; Bulloch, Karen

    2016-05-17

    Certain components and functions of the immune system, most notably cytokine production and immune cell migration, are under circadian regulation. Such regulation suggests that circadian rhythms may have an effect on disease onset, progression, and resolution. In the vesicular stomatitis virus (VSV)-induced encephalitis model, the replication, caudal penetration, and survivability of intranasally applied VSV depends on both innate and adaptive immune mechanisms. In the current study, we investigated the effect of circadian time of infection on the progression and outcome of VSV-induced encephalitis and demonstrated a significant decrease in the survival rate in mice infected at the start of the rest cycle, zeitgeber time 0 (ZT0). The lower survival rate in these mice was associated with higher levels of circulating chemokine (C-C motif) ligand 2 (CCL2), a greater number of peripherally derived immune cells accumulating in the olfactory bulb (OB), and increased production of proinflammatory cytokines, indicating an immune-mediated pathology. We also found that the acrophase of molecular circadian clock component REV-ERBα mRNA expression in the OB coincides with the start of the active cycle, ZT12, when VSV infection results in a more favorable outcome. This result led us to hypothesize that REV-ERBα may mediate the circadian effect on survival following VSV infection. Blocking REV-ERBα activity before VSV administration resulted in a significant increase in the expression of CCL2 and decreased survival in mice infected at the start of the active cycle. These data demonstrate that REV-ERBα-mediated inhibition of CCL2 expression during viral-induced encephalitis may have a protective effect.

  20. Book Review: John M. Hobson and Leonard Seabrooke (2007) (eds) Everyday Politics of the World Economy

    DEFF Research Database (Denmark)

    Strange, Michael Stewart

    2009-01-01

    Book Review: John M. Hobson and Leonard Seabrooke (2007) (eds) Everyday Politics of the World Economy (Cambridge: Cambridge University Press), 254pp. Udgivelsesdato: 2009......Book Review: John M. Hobson and Leonard Seabrooke (2007) (eds) Everyday Politics of the World Economy (Cambridge: Cambridge University Press), 254pp. Udgivelsesdato: 2009...

  1. Multiple Intelligence and Digital Learning Awareness of Prospective B.Ed Teachers

    Science.gov (United States)

    Gracious, F. L. Antony; Shyla, F. L. Jasmine Anne

    2012-01-01

    The present study Multiple Intelligence and Digital Learning Awareness of prospective B.Ed teachers was probed to find the relationship between Multiple Intelligence and Digital Learning Awareness of Prospective B.Ed Teachers. Data for the study were collected using self made Multiple Intelligence Inventory and Digital Learning Awareness Scale.…

  2. A Review of "Older, Wiser, Sexually Smarter: 30 Sex Ed Lessons for Adults Only"

    Science.gov (United States)

    Garrity, Joan Mogul

    2010-01-01

    While virtually all sex ed curricula are designed to be used with children, teens and young adults, "Older, Wiser, Sexually Smarter: 30 Sex Ed Lessons for Adults Only" ([C] 2009, Planned Parenthood of Greater Northern New Jersey) offers lessons to help participants fully embrace the possibility of sexual pleasure and intimacy from mid-life through…

  3. MobilED – a mobile tools and services platform for formal and informal learning

    CSIR Research Space (South Africa)

    Ford, M

    2006-10-01

    Full Text Available The MobilED initiative is aimed at designing teaching and learning environments that are meaningfully enhanced with mobile technologies and services. The MobilED deliverables are to develop a set of scenarios and guidelines of how mobile...

  4. "What about Bilingualism?" A Critical Reflection on the edTPA with Teachers of Emergent Bilinguals

    Science.gov (United States)

    Kleyn, Tatyana; López, Dina; Makar, Carmina

    2015-01-01

    Amidst the debates surrounding teacher quality and preparation programs, the edTPA (education Teaching Performance Assessment) has emerged to assess future teachers through a portfolio-based certification process. This study offers the perspective of three faculty members who participated in an experimental configuration of edTPA implementation…

  5. An EDS1 orthologue is required for N-mediated resistance against tobacco mosaic virus.

    Science.gov (United States)

    Peart, Jack R; Cook, Graeme; Feys, Bart J; Parker, Jane E; Baulcombe, David C

    2002-03-01

    In Arabidopsis, EDS1 is essential for disease resistance conferred by a structural subset of resistance (R) proteins containing a nucleotide-binding site, leucine-rich-repeats and amino-terminal similarity to animal Toll and Interleukin-1 (so-called TIR-NBS-LRR proteins). EDS1 is not required by NBS-LRR proteins that possess an amino-terminal coiled-coil motif (CC-NBS-LRR proteins). Using virus-induced gene silencing (VIGS) of a Nicotiana benthaminana EDS1 orthologue, we investigated the role of EDS1 in resistance specified by structurally distinct R genes in transgenic N. benthamiana. Resistance against tobacco mosaic virus mediated by tobacco N, a TIR-NBS-LRR protein, was EDS1-dependent. Two other R proteins, Pto (a protein kinase), and Rx (a CC-NBS-LRR protein) recognizing, respectively, a bacterial and viral pathogen did not require EDS1. These data, together with the finding that expression of N. benthamiana and Arabidopsis EDS1 mRNAs are similarly regulated, lead us to conclude that recruitment of EDS1 by TIR-NBS-LRR proteins is evolutionarily conserved between dicotyledenous plant species in resistance against bacterial, oomycete and viral pathogens. We further demonstrate that VIGS is a useful approach to dissect resistance signaling pathways in a genetically intractable plant species.

  6. Minimizing ED Waiting Times and Improving Patient Flow and Experience of Care

    Directory of Open Access Journals (Sweden)

    Assaad Sayah

    2014-01-01

    Full Text Available We conducted a pre- and postintervention analysis to assess the impact of a process improvement project at the Cambridge Hospital ED. Through a comprehensive and collaborative process, we reengineered the emergency patient experience from arrival to departure. The ED operational changes have had a significant positive impact on all measured metrics. Ambulance diversion decreased from a mean of 148 hours per quarter before changes in July 2006 to 0 hours since April 2007. ED total length of stay decreased from a mean of 204 minutes before the changes to 132 minutes. Press Ganey patient satisfaction scores rose from the 12th percentile to the 59th percentile. ED patient volume grew by 11%, from a mean of 7,221 patients per quarter to 8,044 patients per quarter. Compliance with ED specific quality core measures improved from a mean of 71% to 97%. The mean rate of ED patients that left without being seen (LWBS dropped from 4.1% to 0.9%. Improving ED operational efficiency allowed us to accommodate increasing volume while improving the quality of care and satisfaction of the ED patients with minimal additional resources, space, or staffing.

  7. The Clock Gene Rev-Erbα Regulates Methamphetamine Actions on Circadian Timekeeping in the Mouse Brain.

    Science.gov (United States)

    Salaberry, Nora L; Mateo, Maria; Mendoza, Jorge

    2017-09-01

    Circadian rhythms are strongly affected by drugs. In rodents, chronic methamphetamine (METH) intake changes circadian activity rhythms, mainly by altering light synchronization that generates the expression of a free-running rhythm with a period longer than 24 h and a second behavioral component that is independent of the main suprachiasmatic (SCN) clock. Although a number of clock genes do not appear to be involved in the effects of METH on circadian behavior, the molecular clockwork controlling these changes is still unclear. Therefore, we investigated the role of the clock gene Rev-Erbα in METH-induced behavioral and molecular responses using knockout mice and their wild-type littermates. Chronic intake of METH alters period circadian behavior of wild-type mice. However, in mice lacking the clock gene Rev-Erbα METH had no effect on their behavioral rhythms. Furthermore, PER2 bioluminescence rhythms in two extra-SCN brain oscillators, the dorsomedial hypothalamus and the habenula, were altered by METH in wild type but not in KO mice. Together, the present results implicate Rev-Erbα in the modulation of the circadian responses to METH and may provide a better comprehension into the mechanisms underlying circadian alterations provoked by drug addiction.

  8. Safety and efficacy of reduced doses of Brucella melitensis strain Rev. 1 vaccine in pregnant Iranian fat-tailed ewes.

    Science.gov (United States)

    Ebrahimi, Mohammad; Nejad, Ramin Bagheri; Alamian, Saeed; Mokhberalsafa, Ladan; Abedini, Fatemeh; Ghaderi, Rainak; Jalali, Hamid Reza

    2012-01-01

    Brucellosis is one of the most important zoonotic diseases and is a significant cause of abortion in animals. Brucella melitensis strain Rev. 1 is recommended as the most effective vaccine for small ruminants but the application of full doses in adult animals is restricted. This study was conducted to determine a proper reduced dose of vaccine which confers protection but which is not abortifacient in Iranian fat-tailed sheep. A total of 51 non-vaccinated pregnant ewes were divided into three main groups and several subgroups. Ewes in different groups were vaccinated at different stages of pregnancy and various subgroups were subcutaneously immunised with different quantities of the micro-organism (7.5 × 10(6), 10(6), 5 × 10(5)). Ewes again became pregnant a year later and were challenged with the wild-type strain to evaluate the protection conferred. Results revealed that the proportion of vaccination-induced abortions was significantly higher in ewes immunised with 7.5 × 10(6) Rev. 1 organisms than in those which received 10(6) or 5 × 10(5) bacteria. While 80% of non-vaccinated ewes aborted after challenge, none of the vaccinated ewes aborted post-challenge. This study indicated that a reduced dose of Rev. 1 vaccine containing 10(6) or 5 × 10(5) live cells could be safely used to induce protection in Iranian fat-tailed sheep at various stages of pregnancy.

  9. Safety and efficacy of reduced doses of Brucella melitensis strain Rev. 1 vaccine in pregnant Iranian fat-tailed ewes

    Directory of Open Access Journals (Sweden)

    Mohammad Ebrahimi

    2012-12-01

    Full Text Available Brucellosis is one of the most important zoonotic diseases and is a significant cause of abortion in animals. Brucella melitensis strain Rev. 1 is recommended as the most effective vaccine for small ruminants but the application of full doses in adult animals is restricted. This study was conducted to determine a proper reduced dose of vaccine which confers protection but which is not abortifacient in Iranian fat-tailed sheep. A total of 51 non-vaccinated pregnant ewes were divided into three main groups and several subgroups. Ewes in different groups were vaccinated at different stages of pregnancy and various subgroups were subcutaneously immunised with different quantities of the micro-organism (7.5 × 106, 106, 5 × 105. Ewes again became pregnant a year later and were challenged with the wild-type strain to evaluate the protection conferred. Results revealed that the proportion of vaccination-induced abortions was significantly higher in ewes immunised with 7.5 × 106 Rev. 1 organisms than in those which received 106 or 5 × 105 bacteria. While 80% of non-vaccinated ewes aborted after challenge, none of the vaccinated ewes aborted post-challenge. This study indicated that a reduced dose of Rev. 1 vaccine containing 106 or 5 × 105 live cells could be safely used to induce protection in Iranian fat-tailed sheep at various stages of pregnancy.

  10. Variation in opioid prescribing patterns between ED providers.

    Science.gov (United States)

    Smulowitz, Peter B; Cary, Chris; Boyle, Katherine L; Novack, Victor; Jagminas, Liudvikas

    2016-12-01

    Abuse of opioid prescription drugs has become an epidemic across the developed world. Despite the fact that emergency physicians overall account for a small proportion of total opioids prescribed, the number of prescriptions has risen dramatically in the past decade and, to some degree, contributes to the available supply of opioids in the community, some of which are diverted for non-medical use. Since successfully reducing opioid prescribing on the individual level first requires knowledge of current prescribing patterns, we sought to determine to what extent variation exists in opioid prescribing patterns at our institution. This was a single-institution observational study at a community hospital with an annual ED volume of 47,000 visits. We determined the number of prescriptions written by each provider, both total number and accounting for the number of patients seen. Our primary outcome measure was the level of variation at the physician level for number of prescriptions written per patient. We also identified the mean number of pills written per prescription. We analyzed data from November 13, 2014 through July 31, 2015 for 21 full-time providers. There were a total of 2211 prescriptions for opioids written over this time period for a total of 17,382 patients seen. On a per-patient basis, the rate of opioid prescriptions written per patient during this period was 127 per 1000 visits (95 % CI 122-132). There was a variation on the individual provider level, with rates ranging from 33 per to 332 per 1000 visits. There was also substantial variation by provider in the number of pills written per prescription with coefficient of variation (standard deviation divided by mean) averaged over different opioids ranging from 16 to 40 %. There was significant variation in opioid prescribing patterns at the individual physician level, even when accounting for the number of patients seen.

  11. Improved spectrum simulation for validating SEM-EDS analysis

    Science.gov (United States)

    Statham, P.; Penman, C.; Duncumb, P.

    2016-02-01

    X-ray microanalysis by SEM-EDS requires corrections for the many physical processes that affect emitted intensity for elements present in the material. These corrections will only be accurate provided a number of conditions are satisfied and it is essential that the correct elements are identified. As analysis is pushed to achieve results on smaller features and more challenging samples it becomes increasingly difficult to determine if all conditions are upheld and whether the analysis results are valid. If a theoretical simulated spectrum based on the measured analysis result is compared with the measured spectrum, any marked differences will indicate problems with the analysis and can prevent serious mistakes in interpretation. To achieve the necessary accuracy a previous theoretical model has been enhanced to incorporate new line intensity measurements, differential absorption and excitation of emission lines, including the effect of Coster-Kronig transitions and an improved treatment of bremsstrahlung for compounds. The efficiency characteristic has been measured for a large area SDD detector and data acquired from an extensive set of standard materials at both 5 kV and 20 kV. The parameterized model has been adjusted to fit measured characteristic intensities and both background shape and intensity at the same beam current. Examples are given to demonstrate how an overlay of an accurate theoretical simulation can expose some non-obvious mistakes and provide some expert guidance towards a valid analysis result. A new formula for calculating the effective mean atomic number for compounds has also been derived that is appropriate and should help improve accuracy in techniques that calculate the bremsstrahlung or use a bremsstrahlung measurement for calibration.

  12. Francesco Fiorentino (ed., Figure e forme della memoria culturale

    Directory of Open Access Journals (Sweden)

    Paola Di Gennaro

    2012-12-01

    Full Text Available Lavorare la memoria, obliare, ricordare, riscrivere il passato con gli strumenti del presente, è questo il soggetto e l’oggetto dei saggi riuniti in questo volume da Francesco Fiorentino, che li introduce attraverso l’operazione artistica di Robert Rauschenberg, il quale, dopo aver chiesto un disegno a de Kooning, maestro dell’Espressionismo astratto, lo espone cancellato. Questa «sottile meditazione iconologica sul tempo edipico dell’arte moderna» (7-8 annuncia uno dei leitmotiv del volume, verità ovvia ma necessaria: se la novità ha valore estetico, come è vero dal Settecento, allora il passato diventa fondamentale come sistema interno dell’arte. È su questo necessario filtro di selezione che agiscono le memorie citate nei saggi seguenti: intersezioni di tracce e cancellazioni, di cui si indagano autenticità, costruzione, ricostruzione, senza che i confini siano tra l’altro mai definiti – ed è questo, forse, che crea l’arte, per suo mezzo e scopo, tramite l’inaffidabilità della memoria: arte che è, come il quadro di Rauschenberg, «rappresentazione della permanenza e, insieme, dell’inattingibilità di ciò che è cancellato» (11. È insomma la «dimensione performativa dell’agire culturale» che viene messa in evidenza in questo volume, memoria che è culturale, appunto, umana e storica, e che, come il Wunderblock di Freud, si cancella ma mai completamente, e mai innocuamente. L’irriconoscibilità finale del ricordo rappresenta quindi il risultato della dimenticanza, e il suo prodotto più creativo. È proprio l’infedeltà della memoria a renderla oggetto sostanziale dell’arte, così come di questo lavoro, oggetto autoriflessivo della memoria collettiva.

  13. 联合应用顺阿曲库铵与维库溴铵后ED50和ED95的改变%The change of ED50 and ED95 for combination of cisatracurium and ve-curonium

    Institute of Scientific and Technical Information of China (English)

    葛培青; 叶照君; 陶伟平; 梁伟民

    2014-01-01

    目的:观察顺式阿曲库铵联合维库溴铵用药后ED50和ED95的变化。方法将75例择期手术患者(ASAⅠ~Ⅱ级)随机分为3组:顺式阿曲库铵组、维库溴铵组和顺式阿曲库铵+维库溴铵组,每组各25例。麻醉诱导后,以单次给药法观察起效时间和T1达到最大抑制的时间,描绘3组患者的量-效曲线,求得各自的ED50和ED95值,并运用等效图法和代数法对两药相互作用进行分析。结果单用顺式阿曲库铵组、维库溴铵组ED50值分别为32.35、28.78μg/kg,ED95值分别为52.67、51.20μg/kg。联合用药时ED50值为16.81、12.17μg/kg,ED95值为23.49、22.16μg/kg,与单独用药相比,差异均有统计学意义。联合用药时ED50和ED95的合用代数值分别为0.942、0.879。结论联合使用顺式阿曲库铵和维库溴铵具有协同作用,且量-效曲线产生左移。%Objective To observe the change of ED50 and ED95 for the treatment with cisatracurium and vecuronium. Methods 75 cases of patients undergoing elective surgery (ASA Ⅰ to II level) were ramdomly divided into three groups:cisatracurium group,vecuronium group and cisatracurium+vecuronium group,each group of 25 cases.The onset time and T1 maximum inhibition time were determined by the single-injection doseresponse technique after anesthesia induction.Their respective ED50 of ED95 values were caculated by the depicted dose-response curve among the three groups of patients.The two medicine interaction analysis was caculated by the equivalent diagram method and algebraic method. Results ED50 was 32.35,28.78 μg/kg and ED95 was 52.67,51.20 μg/kg when patients were given single dose of atracurium or vecuronium.ED50 was 16.81,12.17 μg/kg and ED95 was 23.49,22.16 μg/kg when it combined the both two groups.Compared with other group,the differences in cisatracurium+vecuronium group were statistically significant.The combinational value of ED50 and ED95 was 0.942 and 0.879,respectively

  14. Accuracy of ED Bedside Ultrasound for Identification of Gallstones: Retrospective Analysis of 575 Studies

    Directory of Open Access Journals (Sweden)

    Scruggs, William

    2008-01-01

    Full Text Available Study Objective: To determine the ability of emergency department (ED physicians to diagnose cholelithiasis with bedside ultrasound. Methods: ED gallbladder ultrasounds recorded over 37 months were compared to radiology ultrasound interpretation. Results: Of 1,690 ED gallbladder ultrasound scans performed during this period, radiology ultrasound was performed in 575/1690 (34% cases. ED physician bedside interpretation was 88% sensitive [95% CI, 84-91] and 87% specific [95% CI, 82-91], while positive predictive value (PPV was 91% [88- 94%] and negative predictive value (NPV was 83% [78-87%], using radiology interpretation as the criterion reference. Conclusion: ED physician ultrasound of the gallbladder for cholelithiasis is both sensitive and specific.

  15. The influence of sonority on the production of words ending in -ed by Brazilian EFL learners

    Directory of Open Access Journals (Sweden)

    Fernanda Delatorre

    2010-11-01

    Full Text Available This study investigated the influence of sonority on the production of vowel epenthesis in verbs ending in -ed by Brazilian learners of English. Participants were twenty-six upper-intermediate Brazilian EFL learners who read and audio-recorded ten paragraphs containing 91 verbs ending in ed. The results demonstrated that sonority influenced mispronunciations since the least sonorous obstruents preceding -ed induced more vowel epenthesis than the more sonorous sonorants, which in turn induced more epenthesis than vowels in the same position. The results also demonstrated that within the class of obstruents, affricates preceding -ed induced more epenthesis than stops, which induced more epenthesis than fricatives, and that, within the class of sonorants, nasals induced more epenthesis than liquids. These results suggest that markedness in terms of sonority affects the production of vowel epenthesis in words ending in -ed.

  16. The influence of sonority on the production of words ending in -ed by Brazilian EFL learners

    Directory of Open Access Journals (Sweden)

    Fernanda Delatorre

    2008-01-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2008n55p83 This study investigated the influence of sonority on the production of vowel epenthesis in verbs ending in -ed by Brazilian learners of English. Participants were twenty-six upper-intermediate Brazilian EFL learners who read and audio-recorded ten paragraphs containing 91 verbs ending in ed. The results demonstrated that sonority influenced mispronunciations since the least sonorous obstruents preceding -ed induced more vowel epenthesis than the more sonorous sonorants, which in turn induced more epenthesis than vowels in the same position. The results also demonstrated that within the class of obstruents, affricates preceding -ed induced more epenthesis than stops, which induced more epenthesis than fricatives, and that, within the class of sonorants, nasals induced more epenthesis than liquids. These results suggest that markedness in terms of sonority affects the production of vowel epenthesis in words ending in -ed.

  17. Teaching and Assessing ED Handoffs: A Qualitative Study Exploring Resident, Attending, and Nurse Perceptions

    Directory of Open Access Journals (Sweden)

    Moira Flanigan

    2015-10-01

    Full Text Available Introduction: The Accreditation Council for Graduate Medical Education requires that residency programs ensure resident competency in performing safe, effective handoffs. Understanding resident, attending, and nurse perceptions of the key elements of a safe and effective emergency department (ED handoff is a crucial step to developing feasible, acceptable educational interventions to teach and assess this fundamental competency. The aim of our study was to identify the essential themes of ED-based handoffs and to explore the key cultural and interprofessional themes that may be barriers to developing and implementing successful ED-based educational handoff interventions. Methods: Using a grounded theory approach and constructivist/interpretivist research paradigm, we analyzed data from three primary and one confirmatory focus groups (FGs at an urban, academic ED. FG protocols were developed using open-ended questions that sought to understand what participants felt were the crucial elements of ED handoffs. ED residents, attendings, a physician assistant, and nurses participated in the FGs. FGs were observed, hand-transcribed, audiorecorded and subsequently transcribed. We analyzed data using an iterative process of theme and subtheme identification. Saturation was reached during the third FG, and the fourth confirmatory group reinforced the identified themes. Two team members analyzed the transcripts separately and identified the same major themes. Results: ED providers identified that crucial elements of ED handoff include the following: 1 Culture (provider buy-in, openness to change, shared expectations of sign-out goals; 2 Time (brevity, interruptions, waiting; 3 Environment (physical location, ED factors; 4 Process (standardization, information order, tools. Conclusion: Key participants in the ED handoff process perceive that the crucial elements of intershift handoffs involve the themes of culture, time, environment, and process. Attention

  18. EdU induces DNA damage response and cell death in mESC in culture.

    Science.gov (United States)

    Kohlmeier, Fanni; Maya-Mendoza, Apolinar; Jackson, Dean A

    2013-03-01

    Recently, a novel DNA replication precursor analogue called 5-ethynyl-2'-deoxyuridine (EdU) has been widely used to monitor DNA synthesis as an alternative to bromodeoxyuridine. Use of EdU benefits from simplicity and reproducibility and the simple chemical detection systems allows excellent preservation of nuclear structure. However, the alkyne moiety is highly reactive, raising the possibility that incorporation might compromise genome stability. To assess the extent of possible DNA damage, we have analysed the effect of EdU incorporation into DNA during short- and long-term cell culture using a variety of cell lines. We show that EdU incorporation has no measurable impact on the rate of elongation of replication forks during synthesis. However, using different cell lines we find that during long-term cell culture variable responses to EdU incorporation are seen, which range from delayed cell cycle progression to complete cell cycle arrest. The most profound phenotypes were seen in mouse embryonic stem cells, which following incorporation of EdU accumulated in the G2/M-phase of the cell cycle before undergoing apoptosis. In long-term cell culture, EdU incorporation also triggered a DNA damage response in all cell types analysed. Our study shows that while EdU is extremely useful to tag sites of on-going replication, for long-term studies (i.e. beyond the cell cycle in which labelling is performed), a careful analysis of cell cycle perturbations must be performed in order to ensure that any conclusions made after EdU treatment are not a direct consequence of EdU-dependent activation of cell stress responses.

  19. Association of Rev-erbα in adipose tissues with Type 2 diabetes mellitus amelioration after gastric bypass surgery in Goto-Kakizaki rats.

    Science.gov (United States)

    Zhang, Rui; Yan, Caifeng; Zhou, Xinrong; Qian, Bangguo; Li, Fuqiang; Sun, Yidan; Shi, Chen; Li, Bing; Saito, Shigeru; Horimoto, Katsuhisa; Zhou, Huarong

    2013-07-15

    We estimated the key molecules related to Type 2 diabetes mellitus (T2DM) in adipose, liver, and muscle tissues, from nonobese diabetic Goto-Kakizaki (GK) rats and their Wistar controls, by computationally analyzing the expression profiles in open source data. With the aid of information from previous reports, Rev-erbα in adipose tissue emerged as one of the most plausible candidates. Here, in animal models, including GK rats surgically treated to ameliorate T2DM, we examined the association of Rev-erbα in adipose tissue with T2DM progression. After analyses of the Rev-erbα mRNA expression in the adipose tissue of our animal models, we compared the Rev-erbα protein expression levels in the adipose, liver, and muscle tissues of GK and Wistar controls at the ages of 1 mo (M), 3M, and 6M. The Rev-erbα protein levels in adipose tissue showed a distinctive pattern, with the negative correlation of an increasing trend in GK rats, and a decreasing trend in Wistar rats during aging, from those in liver and muscle tissues. Moreover, dysregulation of the circadian Rev-erbα expression in the adipose tissue of 6-mo-old GK rats was also observed. In particular, we ameliorated T2DM in GK rats by gastric bypass surgery, and revealed that T2DM amelioration in diabetic GK rats was associated with improved circadian Rev-erbα expression, in a comparison between the surgically treated and untreated GK rats. The roles of Rev-erbα in adipose tissue were further investigated by observations of Rev-erbα-related molecules, with reference to previous reports.

  20. Rapid Primary Care Follow-up from the ED to Reduce Avoidable Hospital Admissions.

    Science.gov (United States)

    Carmel, Amanda S; Steel, Peter; Tanouye, Robert; Novikov, Aleksey; Clark, Sunday; Sinha, Sanjai; Tung, Judy

    2017-08-01

    Hospital admissions from the emergency department (ED) now account for approximately 50% of all admissions. Some patients admitted from the ED may not require inpatient care if outpatient care could be optimized. However, access to primary care especially immediately after ED discharge is challenging. Studies have not addressed the extent to which hospital admissions from the ED may be averted with access to rapid (next business day) primary care follow-up. We evaluated the impact of an ED-to-rapid-primary-care protocol on avoidance of hospitalizations in a large, urban medical center. We conducted a retrospective review of patients referred from the ED to primary care (Weill Cornell Internal Medicine Associates - WCIMA) through a rapid-access-to-primary-care program developed at New York-Presbyterian / Weill Cornell Medical Center. Referrals were classified as either an avoided admission or not, and classifications were performed by both emergency physician (EP) and internal medicine physician reviewers. We also collected outcome data on rapid visit completion, ED revisits, hospitalizations and primary care engagement. EPs classified 26 (16%) of referrals for rapid primary care follow-up as avoided admissions. Of the 162 patients referred for rapid follow-up, 118 (73%) arrived for their rapid appointment. There were no differences in rates of ED revisits or subsequent hospitalizations between those who attended the rapid follow-up and those who did not attend. Patients who attended the rapid appointment were significantly more likely to attend at least one subsequent appointment at WCIMA during the six months after the index ED visit [N=55 (47%) vs. N=8 (18%), P=0.001]. A rapid-ED-to-primary-care-access program may allow EPs to avoid admitting patients to the hospital without risking ED revisits or subsequent hospitalizations. This protocol has the potential to save costs over time. A program such as this can also provide a safe and reliable ED discharge option

  1. ED50 and ED95 of Intrathecal Bupivacaine Coadministered with Sufentanil for Cesarean Delivery Under Combined Spinal-epidural in Severely Preeclamptic Patients

    Institute of Scientific and Technical Information of China (English)

    Fei Xiao; Wen-Ping Xu; Xiao-Min Zhang; Yin-Fa Zhang; Li-Zhong Wang; Xin-Zhong Chen

    2015-01-01

    Background:Spinal anesthesia was considered as a reasonable anesthetic option in severe preeclampsia when cesarean delivery is indicated,and there is no indwelling epidural catheter or contraindication to spinal anesthesia.However,the ideal dose of intrathecal bupivacaine has not been quantified for cesarean delivery for severe preeclamptic patients.This study aimed to determine the ED50 and ED95 of intrathecal bupivacaine for severely preeclamptic patients undergoing elective cesarean delivery.Methods:Two hundred severely preeclamptic patients are undergoing elective cesarean delivery under combined spinal-epidural anesthesia enrolled in this randomized,double-blinded,dose-ranging study.Patients received 4 mg,6 mg,8 mg,or 10 mg intrathecal hyperbaric bupivacaine with 2.5 μg sufentanil.Successful spinal anesthesia was defined as a T6 sensory level achieved within 10 minutes after intrathecal drug administration and/or no epidural supplement was required during the cesarean section.The ED50 and ED95 were calculated with a logistic regression model.Results:ED50 and ED95 ofintrathecal bupivacaine for successful spinal anesthesia were 5.67 mg (95% confidence interval [CI]:5.20-6.10 mg) and 8.82 mg (95% CI:8.14-9.87 mg) respectively.The incidence of hypotension in Group 8 mg and Group 10 mg was higher than that in Group 4 mg and Group 6 mg (P < 0.05).The sensory block was significantly different among groups 10 minutes after intrathecal injection (P < 0.05).The use of lidocaine in Group 4 mg was higher than that in other groups (P < 0.05).The use of phenylephrine in Group 8 mg and Group 10 mg was higher than that in the other two groups (P < 0.05).The lowest systolic blood pressure before the infant delivery of Group 8 mg and Group 10 mg was lower than the other two groups (P < 0.05).The satisfaction of muscle relaxation in Group 4 mg was lower than other groups (P < 0.05).There was no significant difference in patients' satisfaction and the newborns

  2. Soil hydraulic properties and REV study using X-ray microtomography and pore-scale modelling: saturated hydraulic conductivity

    Science.gov (United States)

    Gerke, Kirill; Khirevich, Siarhei; Sizonenko, Timofey; Karsanina, Marina; Umarova, Aminat; Korost, Dmitry; Matthai, Stephan; Mallants, Dirk

    2016-04-01

    To verify pore-scale modelling approach for determination of soil saturated hydraulic conductivity properties we scanned three cylindrical soil samples taken from A, Ah and B horizons using X-ray microtomography method. Resulting 3D soil images with resolutions of 15.25-20.96 μm were segmented into pores and solids and their maximum inscribed cube subvolumes were used as input data for three major pore-scale modelling methods to simulate saturated flow - lattice-Boltzmann method, finite-difference solution of the Stokes problem, and pore-network model. Provided that imaging resolution is high enough to capture the backbone of effective porosity and the main conducting pores all three methods resulted in simulated soil permeabilities close to experimental values for Ah and B samples. The resolution of A sample was not enough for an accurate modelling and we concluded that this soil requires multi-scale imaging to cover all relevant heterogeneities. We demonstrate that popular SWV method to choose segmentation threshold resulted in oversegmentation and order of magnitude higher permeability values. Careful manual thresholding combined with local segmentation algorithm provided much more accurate results. Detailed analysis of water retention curves showed that air-filled porosity at relevant pressure stages cannot be used for verification of the segmentation results. Representativity analysis by simulating flow in increasing soil volume up to 2.8 cm3 revealed no representative elementary volume (REV) within Ah sample and non-uniqueness of REV for B sample. The latter was explained by soil structure non-stationarity. We further speculate that structures soil horizons can exhibit no REV at all. We discuss numerous advantages of coupled imaging and pore-scale modelling approach and show how it can become a successor of the conventional soil coring method to parametrize large scale continuum models.

  3. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells

    Energy Technology Data Exchange (ETDEWEB)

    Morioka, Norimitsu, E-mail: mnori@hiroshima-u.ac.jp; Tomori, Mizuki; Zhang, Fang Fang; Saeki, Munenori; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro

    2016-01-08

    Under physiological conditions, astrocytes maintain homeostasis in the CNS. Following inflammation and injury to the CNS, however, activated astrocytes produce neurotoxic molecules such as cytokines and chemokines, amplifying the initial molecular-cellular events evoked by inflammation and injury. Nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammation- and metabolism-related gene transcription. The current study sought to elucidate a role of REV-ERBs in rat C6 astroglial cells on the expression of inflammatory molecules following stimulation with the neuroinflammatory cytokine tumor necrosis factor (TNF). Stimulation of C6 cells with TNF (10 ng/ml) significantly increased the mRNA expression of CCL2, interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and matrix metalloprotease (MMP)-9, but not fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (COX-2) and MMP-2. Treatment with either REV-ERB agonists GSK4112 or SR9009 significantly blocked TNF-induced upregulation of CCL2 mRNA and MMP-9 mRNA, but not IL-6 mRNA and iNOS mRNA expression. Furthermore, treatment with RGFP966, a selective histone deacetylase 3 (HDAC3) inhibitor, potently reversed the inhibitory effects of GSK4112 on TNF-induced expression of MMP-9 mRNA, but not CCL2 mRNA. Expression of Rev-erbs mRNA in C6 astroglial cells, primary cultured rat cortical and spinal astrocytes was confirmed by reverse transcription polymerase chain reaction. Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 and CCL2 transcription, of astroglial REV-ERBs activation through HDAC3-dependent and HDAC3-independent mechanisms. - Highlights: • Rev-erbα mRNA and Rev-erbβ mRNA are expressed in C6 astroglial cells. • TNF increases the expression of CCL2, IL-6, MMP-9 and iNOS mRNA. • REV-ERB activation inhibits CCL2 mRNA and MMP-9 mRNA expression. • HDAC3 activity is involved in the inhibitory effect of REV-ERB on MMP-9 induction.

  4. Numerical modelling of the flow in the resin infusion process on the REV scale: A feasibility study

    DEFF Research Database (Denmark)

    Jabbaribehnam, Mirmasoud; Jambhekar, V. A.; Gersborg, A. R.

    2016-01-01

    development. In this paper, we show the implementation of 2D numerical models for the RIP using the open source simulator DuMuX. The idea of this study is to present a model which accounts for the interfacial forces coming from the capillary pressure on the so-called representative elementary volume (REV......) scale. The model is described in detail and three different test cases - a constant and a tensorial permeability as well as a preform/Balsa domain - are investigated. The results show that the developed model is very applicable for the RIP for manufacturing of composite parts. The idea behind this study...

  5. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-15

    As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind

  6. Comments on Letter (Phys. Rev. L, Vol.89, No. 10,2002) by D. Shapira and M. Saltmarsh

    CERN Document Server

    Taleyarkhan, Rusi P; Cho, JaeSeon; Lahey, Richard T; Nigmatulin, Robert I; Block, Robert C

    2013-01-01

    This article focuses on correcting several factual errors and critiques in the previously published Letter in Phys. Rev. L, Vol. 89, No. 10, 2022, by D. Shapira and M. Saltmarsh. The authors of the Letter did not perform their own "independent" experiments as claimed; they did not perform control experiments with normal acetone; and, neither did they monitor for tritium. It their Letter, the authors (D. Shapira and M. Saltmarsh) failed to disclose that the data they collected actually confirmed our claims of having observed statistically significant nuclear emissions in chilled, cavitated deuterated acetone.

  7. Resurrection of Auritibicen shikokuanus (Kato, 1959 stat. rev. & comb. nov. (Hemiptera: Cicadidae: Cryptotympanini from Ehime and Hiroshima of Japan

    Directory of Open Access Journals (Sweden)

    Young June Lee

    2017-03-01

    Full Text Available Auritibicen shikokuanus (Kato, 1959 stat. rev. & comb. nov. (Hemiptera: Cicadidae: Cryptotympanini from Ehime Prefecture (Shikoku of Japan is resurrected from junior synonymy with Auritibicen kyushyuensis (Kato, 1926. Auritibicen ishiharai (Kato, 1959 syn. nov. & comb. nov. from Hiroshima Prefecture (Honshu of Japan is resurrected from junior synonymy with A. kyushyuensis and then is synonymized with A. shikokuanus. Morphological comparisons are made among closely related species, A. shikokuanus, A. kyushyuensis, and Auritibicen intermedius (Mori, 1931.

  8. Residual virulence and immunogenicity of CGV26 and CGV2631 B. melitensis Rev. 1 deletion mutant strains in sheep after subcutaneous or conjunctival vaccination.

    Science.gov (United States)

    Guilloteau, Laurence A; Laroucau, Karine; Olivier, Michel; Grillo, Maria Jesus; Marin, Clara M; Verger, Jean-Michel; Blasco, Jose-Maria

    2006-04-24

    The CGV26 and CGV2631 strains are novel engineered Brucella melitensis Rev.1 mutant strains deleted for the bp26 gene or for both bp26 and omp31 genes, respectively, coding for proteins of diagnostic significance. The residual virulence and immunogenicity of both mutants were compared to the parental Rev.1 strain in sheep after subcutaneous or conjunctival vaccination. The deletion of the bp26 gene or both bp26 and omp31 genes had no significant effect on the intracellular survival of the Rev.1 strain in ovine macrophage cultures. The kinetics of infection induced by both mutants in sheep was similar to the Rev.1 strain, and inoculation by the subcutaneous route produced wider and more generalized infections than the conjunctival route. All strains were cleared from lymph nodes and organs within 3 months after inoculation. The CGV26 and CGV2631 mutants induced both specific systemic antibody response and lymphoproliferation in sheep. The kinetics of the responses induced by the mutants was quite similar to that of the parental Rev.1 strain, except for the intensity of the lymphoproliferative response, which was attenuated for the CGV2631 mutant. In conclusion, the residual virulence of both CGV26 and CGV2631 mutants in sheep was similar to that of the parental Rev.1 vaccine strain. These mutants induced also significant specific antibody and cell-mediated immunity in sheep and are suitable to be evaluated as potential vaccine candidates against B. melitensis and B. ovis infections in sheep.

  9. Review: Abdul Raufu Mustapha (ed., Sects & Social Disorder: Muslim Identities & Conflict in Northern Nigeria (2014

    Directory of Open Access Journals (Sweden)

    Heinrich Bergstresser

    2015-01-01

    Full Text Available Review of the edited volume:Abdul Raufu Mustapha (ed., Sects & Social Disorder: Muslim Identities & Conflict in Northern Nigeria, Martlesham: James Currey, 2014, ISBN 9781847011077, 256 pages

  10. Review: Funston, John (ed. (2009, Divided Over Thaksin: Thailand’s Coup and Problematic Transition

    Directory of Open Access Journals (Sweden)

    Paul Chambers

    2010-04-01

    Full Text Available Review of the edited volume: Funston, John (ed. (2009, Divided Over Thaksin: Thailand’s Coup and Problematic Transition, Chiangmai: Silkworm Books, Singapore: ISEAS. ISBN 978-981-230-961-7, 203 pages.

  11. Hispaania võib oma väed Iraagist ära tuua / Erkki Bahovski

    Index Scriptorium Estoniae

    Bahovski, Erkki, 1970-

    2004-01-01

    Hispaania parlamendivalimised võitnud sotsialistliku partei liider, arvatav uus peaminister Jose Luis Rodriguez Zapatero lubas Hispaania väed Iraagist ära tuua. Diagrammid: Hispaania valimistulemused

  12. Modified Adomian decomposition method for fracture of laminated uni-directional composites

    Indian Academy of Sciences (India)

    B K Raghu Prasad; P V Ramana

    2012-02-01

    In this paper, the well-known Adomian Decomposition Method (ADM) is modified to solve the fracture laminated multi-directional problems. The results are compared with the existing analytical/exact or experimental method. The already known existing ADM is modified to improve the accuracy and convergence. Thus, the modified method is named as Modified Adomian Decomposition Method (MADM). The results from MADM are found to converge very quickly, simple to apply for fracture(singularity) problems and are more accurate compared to experimental and analytical methods. MADM is quite efficient and is practically well-suited for use in these problems. Several examples are given to check the reliability of the present method. In the present paper, the principle of the decomposition method is described, and its advantages form the analyses of fracture of laminated uni-directional composites.

  13. Hispaania võib oma väed Iraagist ära tuua / Erkki Bahovski

    Index Scriptorium Estoniae

    Bahovski, Erkki, 1970-

    2004-01-01

    Hispaania parlamendivalimised võitnud sotsialistliku partei liider, arvatav uus peaminister Jose Luis Rodriguez Zapatero lubas Hispaania väed Iraagist ära tuua. Diagrammid: Hispaania valimistulemused

  14. Jean Libis, Fabio Ferreira, Catherine Gublin, Sarah Mezaguer (eds.), Les Lectures de Gaston Bachelard. Index bibliographique

    OpenAIRE

    Aurosa Alison

    2012-01-01

    Jean Libis, Fabio Ferreira, Catherine Gublin, Sarah Mezaguer (eds.), Les Lectures de Gaston Bachelard. Index bibliographique (Paris, Presse Universitaire de Franche-Comté, 2011 ISBN: 978-2-84867-392) di     Aurosa Alison

  15. Voyager, a journey into the unknown - an interview with Ed Stone (Caltech), Voyager project scientist

    CERN Multimedia

    CERN Video productions; Piotr Traczyk

    2012-01-01

    Voyager, a journey into the unknown - an interview with Ed Stone (Caltech), Voyager project scientist, interviewed on the 100th anniversary of the discovery of Cosmic Rays conference, Spaceparts, at CERN in November 2012.

  16. Ekspert : "Väed Afganistanist välja!" / Aadu Hiietamm

    Index Scriptorium Estoniae

    Hiietamm, Aadu, 1954-

    2007-01-01

    Saksa kriisiekspert Peter Scholl-Latour on seisukohal, et välisväed peavad Afganistanist lahkuma, sest seni pole keegi suutnud seal sõda võita. P. Scholl-Latouri artiklist poliitikaajakirjas Cicero

  17. Jean Libis, Fabio Ferreira, Catherine Gublin, Sarah Mezaguer (eds., Les Lectures de Gaston Bachelard. Index bibliographique

    Directory of Open Access Journals (Sweden)

    Aurosa Alison

    2012-10-01

    Full Text Available Jean Libis, Fabio Ferreira, Catherine Gublin, Sarah Mezaguer (eds., Les Lectures de Gaston Bachelard. Index bibliographique (Paris, Presse Universitaire de Franche-Comté, 2011 ISBN: 978-2-84867-392 di  Aurosa Alison

  18. Balanced nuclear and cytoplasmic activities of EDS1 are required for a complete plant innate immune response.

    Directory of Open Access Journals (Sweden)

    Ana V García

    Full Text Available An important layer of plant innate immunity to host-adapted pathogens is conferred by intracellular nucleotide-binding/oligomerization domain-leucine rich repeat (NB-LRR receptors recognizing specific microbial effectors. Signaling from activated receptors of the TIR (Toll/Interleukin-1 Receptor-NB-LRR class converges on the nucleo-cytoplasmic immune regulator EDS1 (Enhanced Disease Susceptibility1. In this report we show that a receptor-stimulated increase in accumulation of nuclear EDS1 precedes or coincides with the EDS1-dependent induction and repression of defense-related genes. EDS1 is capable of nuclear transport receptor-mediated shuttling between the cytoplasm and nucleus. By enhancing EDS1 export from inside nuclei (through attachment of an additional nuclear export sequence (NES or conditionally releasing EDS1 to the nucleus (by fusion to a glucocorticoid receptor (GR in transgenic Arabidopsis we establish that the EDS1 nuclear pool is essential for resistance to biotrophic and hemi-biotrophic pathogens and for transcriptional reprogramming. Evidence points to post-transcriptional processes regulating receptor-triggered accumulation of EDS1 in nuclei. Changes in nuclear EDS1 levels become equilibrated with the cytoplasmic EDS1 pool and cytoplasmic EDS1 is needed for complete resistance and restriction of host cell death at infection sites. We propose that coordinated nuclear and cytoplasmic activities of EDS1 enable the plant to mount an appropriately balanced immune response to pathogen attack.

  19. Balanced nuclear and cytoplasmic activities of EDS1 are required for a complete plant innate immune response.

    Science.gov (United States)

    García, Ana V; Blanvillain-Baufumé, Servane; Huibers, Robin P; Wiermer, Marcel; Li, Guangyong; Gobbato, Enrico; Rietz, Steffen; Parker, Jane E

    2010-07-01

    An important layer of plant innate immunity to host-adapted pathogens is conferred by intracellular nucleotide-binding/oligomerization domain-leucine rich repeat (NB-LRR) receptors recognizing specific microbial effectors. Signaling from activated receptors of the TIR (Toll/Interleukin-1 Receptor)-NB-LRR class converges on the nucleo-cytoplasmic immune regulator EDS1 (Enhanced Disease Susceptibility1). In this report we show that a receptor-stimulated increase in accumulation of nuclear EDS1 precedes or coincides with the EDS1-dependent induction and repression of defense-related genes. EDS1 is capable of nuclear transport receptor-mediated shuttling between the cytoplasm and nucleus. By enhancing EDS1 export from inside nuclei (through attachment of an additional nuclear export sequence (NES)) or conditionally releasing EDS1 to the nucleus (by fusion to a glucocorticoid receptor (GR)) in transgenic Arabidopsis we establish that the EDS1 nuclear pool is essential for resistance to biotrophic and hemi-biotrophic pathogens and for transcriptional reprogramming. Evidence points to post-transcriptional processes regulating receptor-triggered accumulation of EDS1 in nuclei. Changes in nuclear EDS1 levels become equilibrated with the cytoplasmic EDS1 pool and cytoplasmic EDS1 is needed for complete resistance and restriction of host cell death at infection sites. We propose that coordinated nuclear and cytoplasmic activities of EDS1 enable the plant to mount an appropriately balanced immune response to pathogen attack.

  20. 2003 annual results of EdF group; Resultats annuels 2003 du groupe EDF

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-03-01

    The Electricite de France (EdF) group Board of Directors, meeting on March 11, 2004, under the Chairmanship of Francois Roussely, reviewed the audited consolidated financial statements for the year ended 12/31/2003. This document presents the consolidated results of EdF group for 2003: consolidated financial statements, highlights of the year, focus on 2003 events, commercial results, EDF in Europe and worldwide, EDF France highlights, key figures. (J.S.)