WorldWideScience

Sample records for rev ecol syst

  1. ECOL Book Catalog.

    Science.gov (United States)

    Minneapolis Public Library, Minn. Environmental Conservation Library.

    This catalog represents the collection of the Environmental Conservation Library oF Minnesota (ECOL) as of September 1973, when it contained over 2,800 titles of books and government documents, augmented by periodicals and substantial numbers of pamphlets, papers, brochures, and related materials. The catalog includes an author and main entry…

  2. Administrative Circulars Rev.

    CERN Multimedia

    2003-01-01

    Administrative Circular N° 19 (Rev. 3) - April 2003 Subsistence indemnity - Other expenses necessarily incurred in the course of duty travelAdministrative Circular N° 25 (Rev. 2) - April 2003 Shift work - Special provisions for the Fire and Rescue Service - These circulars have been revised. Human Resources Division Tel. 74128Copies of these circulars are available in the Divisional Secretariats. In addition, administrative and operational circulars, as well as the lists of those in force, are available for consultation on the Web at: http://humanresources.web.cern.ch/humanresources/internal/admin_services/admincirc/listadmincirc.asp

  3. SEM-REV: A sea test site for Marine Energy Converter

    International Nuclear Information System (INIS)

    Berhault, Christian; Le Crom, Izan; Le Bihan, Gerard

    2015-01-01

    Thanks to a main funding of Region des Pays de la Loire, the sea test site SEM-REV has been developed by Ecole Centrale de Nantes since 2007 to test both Wave Energy Converters and Floating Wind Turbine in real sea conditions. The sea test site is equipped with a set of oceanographic sensors and with an electric cable of 8 MW, connected to the French grid. The project is located close to Le Croisic, Western coast of France. SEM-REV is one of the main test facilities operated by Ecole Centrale de Nantes to support MRE technologies development. After presenting the initial motivations of the SEM-REV development, the paper describes, in parts 1 and 2, the complete administrative and technical processes that were followed to reach SEM-REV commissioning in 2014. The third part is focused on the exploitation process, including technical and contractual specifications imposed to the MRE developers for installation, tests and decommissioning phases. Some words are given also on the R and D projects using the SEM-REV in-situ monitoring system: prediction of environmental conditions, bio-fooling, acoustic impact. Even if operational phase is not started, expected extensions of the tests site are listed. (authors)

  4. Implementace ERP systémů

    OpenAIRE

    Přívratský, Miroslav

    2008-01-01

    První část této práce uvádí vztah ERP systémů a jiných aplikací běžně zaváděných v podnikových informačních systémech a rozvádí funkcionalitu ERP systémů. Druhá část se poté věnuje detailní kategorizaci ERP produktů z mnoha různých hledisek a analyzuje obecné parametry, podle kterých je možné ERP systémy posuzovat (např. při výběru produktu, který má být implementován). Poslední část je zaměřena na projekty implementace ERP systémů, jejich průběh a hodnocení jejich úspěšnosti. Na závěr práce ...

  5. The SysteMHC Atlas project.

    Science.gov (United States)

    Shao, Wenguang; Pedrioli, Patrick G A; Wolski, Witold; Scurtescu, Cristian; Schmid, Emanuel; Vizcaíno, Juan A; Courcelles, Mathieu; Schuster, Heiko; Kowalewski, Daniel; Marino, Fabio; Arlehamn, Cecilia S L; Vaughan, Kerrie; Peters, Bjoern; Sette, Alessandro; Ottenhoff, Tom H M; Meijgaarden, Krista E; Nieuwenhuizen, Natalie; Kaufmann, Stefan H E; Schlapbach, Ralph; Castle, John C; Nesvizhskii, Alexey I; Nielsen, Morten; Deutsch, Eric W; Campbell, David S; Moritz, Robert L; Zubarev, Roman A; Ytterberg, Anders Jimmy; Purcell, Anthony W; Marcilla, Miguel; Paradela, Alberto; Wang, Qi; Costello, Catherine E; Ternette, Nicola; van Veelen, Peter A; van Els, Cécile A C M; Heck, Albert J R; de Souza, Gustavo A; Sollid, Ludvig M; Admon, Arie; Stevanovic, Stefan; Rammensee, Hans-Georg; Thibault, Pierre; Perreault, Claude; Bassani-Sternberg, Michal; Aebersold, Ruedi; Caron, Etienne

    2018-01-04

    Mass spectrometry (MS)-based immunopeptidomics investigates the repertoire of peptides presented at the cell surface by major histocompatibility complex (MHC) molecules. The broad clinical relevance of MHC-associated peptides, e.g. in precision medicine, provides a strong rationale for the large-scale generation of immunopeptidomic datasets and recent developments in MS-based peptide analysis technologies now support the generation of the required data. Importantly, the availability of diverse immunopeptidomic datasets has resulted in an increasing need to standardize, store and exchange this type of data to enable better collaborations among researchers, to advance the field more efficiently and to establish quality measures required for the meaningful comparison of datasets. Here we present the SysteMHC Atlas (https://systemhcatlas.org), a public database that aims at collecting, organizing, sharing, visualizing and exploring immunopeptidomic data generated by MS. The Atlas includes raw mass spectrometer output files collected from several laboratories around the globe, a catalog of context-specific datasets of MHC class I and class II peptides, standardized MHC allele-specific peptide spectral libraries consisting of consensus spectra calculated from repeat measurements of the same peptide sequence, and links to other proteomics and immunology databases. The SysteMHC Atlas project was created and will be further expanded using a uniform and open computational pipeline that controls the quality of peptide identifications and peptide annotations. Thus, the SysteMHC Atlas disseminates quality controlled immunopeptidomic information to the public domain and serves as a community resource toward the generation of a high-quality comprehensive map of the human immunopeptidome and the support of consistent measurement of immunopeptidomic sample cohorts. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  6. The SysteMHC Atlas project

    DEFF Research Database (Denmark)

    Shao, Wenguang; Pedrioli, Patrick G. A.; Wolski, Witold

    2018-01-01

    consisting of consensus spectra calculated from repeat measurements of the same peptide sequence, and links to other proteomics and immunology databases. The SysteMHC Atlas project was created and will be further expanded using a uniform and open computational pipeline that controls the quality of peptide......-scale generation of immunopeptidomic datasets and recent developments in MS-based peptide analysis technologies now support the generation of the required data. Importantly, the availability of diverse immunopeptidomic datasets has resulted in an increasing need to standardize, store and exchange this type of data...

  7. Optimized Chemical Probes for REV-ERBα

    OpenAIRE

    Trump, Ryan P.; Bresciani, Stefano; Cooper, Anthony W. J.; Tellam, James P.; Wojno, Justyna; Blaikley, John; Orband-Miller, Lisa A.; Kashatus, Jennifer A.; Dawson, Helen C.; Loudon, Andrew; Ray, David; Grant, Daniel; Farrow, Stuart N.; Willson, Timothy M.; Tomkinson, Nicholas C. O.

    2013-01-01

    REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability. Potent REV-ERBα agonists 4, 10, 16, and 23 are detailed for their ability to suppress BMAL and IL-6 expression from human cells while also demonstrating excellent selectivity over LXRα. Amine 4 demonstrated in vivo bioavailability after either IV o...

  8. Analysis of the Cochrane review : topical treatments for scalp psoriasis : Cochrane Database Syst Rev. 2016;2:CD009687

    OpenAIRE

    Queirós, Catarina Soares; Duarte, Gonçalo Silva; Costa, João; Carneiro, António Vaz

    2017-01-01

    Copyright © Ordem dos Médicos 2017 Regardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The...

  9. Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.

    Directory of Open Access Journals (Sweden)

    Catarina Soares Queirós

    2017-03-01

    Full Text Available Regardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The objective of this review was to evaluate the efficacy and safety of topical treatments for scalp psoriasis. A systematic review was performed according to the methodology recommended by Cochrane in order to evaluate the clinical severity of psoriasis, quality of life, and adverse events that led to treatment discontinuation. To evaluate this, 59 studies were included, with a total of 11 561 participants, and 15 comparisons were made between the various drugs and application vehicles tested. The principal conclusion is that corticosteroids of high or very high potency are more effective than vitamin D. The combination of a corticosteroid with vitamin D has only a marginal benefit over corticosteroid monotherapy, but is superior to vitamin D alone. Given the similar safety profile and only marginal benefit of the combination of corticosteroid with vitamin D over the corticosteroid alone, topical corticosteroid monotherapy appears to be fully acceptable for short-term therapy of scalp psoriasis.

  10. Alcances y limitaciones del concepto de huella ecológica

    OpenAIRE

    Higueras García, Esther

    2013-01-01

    Alcances y limitaciones del concepto de huella ecologica .- Antecedentes, Objetivo y definición de huella ecológica .- Cálculo de la huella ecológica .- Factores no recogidos por el indicador .- Reflexiones finales

  11. Une Exception Francaise: Les Grandes Ecoles (A French Exception: The Great Schools).

    Science.gov (United States)

    Kimmel, Alain

    1996-01-01

    Examines the role of exceptional schools in France that have produced famous personages such as Charles de Gaulle and Jean-Paul Sartre. The schools reviewed include L'Ecole Nationale d'Administration, L'Ecole Polytechnique, L'Ecole Normale Superieure, L'Ecole des Hautes Etudes Commerciales, Saint-Cyr, and L'Institut d'Etudes Politiques de Paris.…

  12. Estrutura espacial e processos ecológicos: o estudo da fragmentação dos habitats

    Directory of Open Access Journals (Sweden)

    Maria Laranjeira

    2012-06-01

    Full Text Available O presente artigo revê a relação entre alguns conceitos e pressupostos fundamentais para a atual investigação ecológica e biogeográfica que, desde meados de 1980, se tem vindo a centrar no estudo do regime e dos efeitos das perturbações ambientais, naturais e antrópicas, sobre espécies e comunidades biológicas. Salienta-se a afirmação crescente da Ecologia da Paisagem, disciplina que enfatiza a importância da heterogeneidade espacial e das relações recíprocas entre os padrões espaciais da paisagem e os processos ecológicos, sobretudo no contexto de uma perturbação como a da fragmentação dos habitats. A base conceptual e os resultados dos principais modelos de simulação espacial e dos estudos empíricos que permitem destrinçar a importância da perda do habitat relativamente à configuração espacial do habitat são sintetizados e discutidos.

  13. Systèmes de Gestion de Production et Systèmes de Contrôle de Gestion

    OpenAIRE

    Travaillé , Denis

    2009-01-01

    L'interrogation fondamentale des travaux de recherche porte sur la question de la séparabilité et de l'interaction entre système de gestion de production et système de contrôle de gestion. Le premier temps de la réflexion concerne la spécificité du contrôle de gestion en contexte de "Juste-à-Temps. Le second temps de la recherche est relatif aux systèmes d'information de production intégrés en relation avec le système de contrôle de gestion et au rôle des représentations comptables dans la qu...

  14. Firemní ERP systém

    OpenAIRE

    Komárek, Lukáš

    2010-01-01

    Tato bakalářská práce pojednává o problematice tvorby ERP systému na platformě .NET Framework s využitím Microsoft technologií. Jednotlivé kapitoly seznámí čtenáře s analýzou, návrhem a implementací vlastního ERP systému. Čtenář bude podrobněji seznámen se zařazením a komponentami ERP systému, moderními vývojovými technologiemi a nástroji, příkladem návrhu modulů a funkcí ERP systému včetně implementace a nasazení aplikace ERP systému. This thesis focuses on the issues while creating the E...

  15. Conciencia social y ecológica en el consumo

    OpenAIRE

    José Raúl Luyando Cuevas

    2016-01-01

    La presente investigación se propone utilizar una concepción diferente del consumo que ayude a amalgamar la principal corriente teórica con el paradigma de la sustentabilidad. A este nuevo enfoque lo denominamos consumo con conciencia social y ecológica. La pretensión es que se pueda utilizar para transitar hacia una producción más sosteni- ble en el corto plazo.

  16. Conciencia social y ecológica en el consumo

    Directory of Open Access Journals (Sweden)

    José Raúl Luyando Cuevas

    2016-01-01

    Full Text Available La presente investigación se propone utilizar una concepción diferente del consumo que ayude a amalgamar la principal corriente teórica con el paradigma de la sustentabilidad. A este nuevo enfoque lo denominamos consumo con conciencia social y ecológica. La pretensión es que se pueda utilizar para transitar hacia una producción más sosteni- ble en el corto plazo.

  17. Innovative Approaches by Ecole Polytechnique de Montreal Library

    OpenAIRE

    Dumont, Richard; Dupuis, Marie-Helene; Focault, Luc; Hiller, Marc; Proulx, Madeline

    2005-01-01

    Librarians are better able to respond to the needs of their end users while supporting the goals of their institution. This is illustrated through five recent initiatives undertaken by the Library of Ecole Polytechnique in direct support of institutional research activities: Master’s and Ph. D. students develop information skills through the preparation of a portfolio on their research topic. This assignment forms part of an information literacy laboratory within a research methodology cour...

  18. Quicklook overview of model changes in Melcor 2.2: Rev 6342 to Rev 9496

    Energy Technology Data Exchange (ETDEWEB)

    Humphries, Larry L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    MELCOR 2.2 is a significant official release of the MELCOR code with many new models and model improvements. This report provides the code user with a quick review and characterization of new models added, changes to existing models, the effect of code changes during this code development cycle (rev 6342 to rev 9496), a preview of validation results with this code version. More detailed information is found in the code Subversion logs as well as the User Guide and Reference Manuals.

  19. Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function

    DEFF Research Database (Denmark)

    Bugge, Anne Skovsø; Feng, Dan; Everett, Logan J

    2012-01-01

    of binding sites across the genome, enriched near metabolic genes. Depletion of both Rev-erbs in liver synergistically derepresses several metabolic genes as well as genes that control the positive limb of the molecular clock. Moreover, deficiency of both Rev-erbs causes marked hepatic steatosis, in contrast......-autonomous clock as well as hepatic lipid metabolism. Mouse embryonic fibroblasts were rendered arrhythmic by depletion of both Rev-erbs. In mouse livers, Rev-erbβ mRNA and protein levels oscillate with a diurnal pattern similar to that of Rev-erbα, and both Rev-erbs are recruited to a remarkably similar set...

  20. Revised Safety Instruction 41 (IS41 REV.)

    CERN Multimedia

    SC Secretariat

    2005-01-01

    Please note that the Revised Safety Instruction No. 41 (IS41 REV.), entitled 'The use of plastic and other non-metallic materials at CERN with respect to fire safety and radiation resistance' is available on the web at the following url: https://edms.cern.ch/document/335806/LAST_RELEASED Paper copies can also be obtained from the SC Unit Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  1. Introducing RevPASH: The Free Webtool Application

    Directory of Open Access Journals (Sweden)

    Peter Szende

    2014-10-01

    Full Text Available RevPASH (Revenue Per Available Seat Hour is an important measure that helps restaurant operators understand how efficiently each seat in a restaurant generates revenue. The RevPASH app is an easy-to-use web-tool that provides an operator with a quick way to input a few relevant numbers and calculate RevPASH.The application has the ability to compare RevPASH over different times, days, weeks, and months.

  2. Desastre ecológico y ambiental en Huancavelica

    OpenAIRE

    Pinto Herrera, Honorio

    2014-01-01

    El trabajo trata de confirmar, una vez más, que la actividad minera en el Perú afecta los sistemas ecológicos y el medio ambiente. Esto es posible debido al poder de las empresas y a la debilidad y complicidad del Estado. En este sentido, uno de los objetivos de esta investigación es contribuir al conocimiento de un problema nacional, que es la contaminación ambiental a partir de un caso concreto: el derrame de relaves en la mina Caudalosa Chica. Los temas centrales desarrollados abarcan l...

  3. Riesgo ecológico del sulfato de bario

    OpenAIRE

    Paredes Espinal, Christian Edgardo

    2016-01-01

    Se desconoce el efecto del sulfato de bario en los ecosistemas acuáticos donde se realizan actividades hidrocarburíferas y que vienen incrementándose a nivel nacional. Por tal motivo, se evaluó el riesgo ecológico del sulfato de bario empleando la respuesta ecotoxicológica de doce organismos no destinatarios a fin de conocer los posibles efectos que este compuesto pudiera estar ocasionando a los organismos relacionados a los ecosistemas marinos y epicontinentales donde se desarrollan activida...

  4. DRG systém v ČR

    OpenAIRE

    Hodyc, Daniel MUDr.

    2007-01-01

    Diplomová práce hodnotí historický proces implementace klasifikačního systému DRG v České republice a srovnává jej s vývojem analogických systémů v ostatních zemích světa. Na podkladě platné metodiky IR DRG užívané v ČR v roce 2006 analyzuje hospitalizační část lékařské péče poskytované ve Fakultní nemocnici v Motole. Zkoumá rozdíly v nákladovosti při srovnání rozdílných pacientských skupin (děti – dospělí, operovaní – léčení konzervativně) a ukazuje výhody užití DRG systému pro hodnocení kva...

  5. Rev 12 as a theology of history

    OpenAIRE

    Joanna Nowińska

    2009-01-01

    The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger), places (the temple, a desert), persons (the Child-Ruler, Michael) with the Old T...

  6. Rev 12 as a theology of history

    Directory of Open Access Journals (Sweden)

    Joanna Nowińska

    2009-12-01

    Full Text Available The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger, places (the temple, a desert, persons (the Child-Ruler, Michael with the Old Testament figurative exposing, a typical one for such a book (the Woman with Child, the heaven, the dragon, enriched with a lot of symbols (a crown, a horn, the moon under feet. God’s interference into World history is presented through lightning, voices, thunder, an earthquake and great hail, that stress His power and supremacy. The biblical writer refers to events, which make place whole the time in the natural- and supernatural space, like: the war between God and evil, persecutions, hiding, God’s care of men.  The specific literary structure of Rev 12, contrary to the other parts of that book, seem to help to put an accent for the fundamental truths for transcendental theology of history of which the most important is the eternal rule of God and only accidental, finished in the time perspective of Satan’s position.

  7. Suppression of atherosclerosis by synthetic REV-ERB agonist

    Energy Technology Data Exchange (ETDEWEB)

    Sitaula, Sadichha [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Billon, Cyrielle [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States); Kamenecka, Theodore M.; Solt, Laura A. [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Burris, Thomas P., E-mail: burristp@slu.edu [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States)

    2015-05-08

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.

  8. Modelo decisional proactivo en sistemas ecológicos (modepec.

    Directory of Open Access Journals (Sweden)

    Pedro Tolón Estarelles

    2007-07-01

    Full Text Available Los sistemas económicos y sociales son de tipo ecológico, y se pueden enmarcar en modelos de sistemas complejos de tipo DYSES (Dynamic Social and Economic Systems. No son  explicables o predecibles satisfactoriamente  con modelos determinísticos, pues, en general obedecen a procesos evolutivos de carácter estocástico, respondiendo en su interacción con el medio al segundo principio de la termodinámica en el sentido de la irreversibilidad (falta de simetría temporal y aumento de la entropía. MODEPEC © es un modelo que postula una metodología que asegura  un proceso  de formulación de criterios  para mejorar continuamente la calidad en la toma  de decisiones en sistemas ecológico-social-económicos. Los conceptos esenciales del modelo se enuncian seguidamente: 1-. Existencia de una Ecuación de Estado (EE Un sistema ecológico tiene un  comportamiento dinámico posible de ser representado mediante una ecuación de estado en cualquier intervalo de tiempo dado. 2-. Estimación de una política óptima (PO Es posible estimar  un conjunto óptimo de decisiones (política óptima. 3-. Contrato sobre estado deseable  (CED En la comunidad  social y económica de tipo ecológico, es posible acordar un diseño de estado ideal deseable, constituido a partir de un contrato sustentable a largo plazo entre las partes. 4-. Genotipo Decisional Planificado (GDP Es posible establecer un proceso racional de toma de decisiones, en este caso, el Genotipo Decisional Planificado  (GDP; capaz de asegurar niveles crecientes de calidad en la determinación de criterios para evaluación y adopción de cursos de acción en pos del logro de un estado deseado (ED tomado como propósito o contrato. The economic and social systems are of ecological type, and they are possible to be framed in models of complex systems of type SDES (Social Dynamic and Economic Systems. They are not explicable or predictable satisfactorily with deterministic models, then

  9. Système de guidage pour ponts roulants

    CERN Document Server

    Caldérone, A

    1999-01-01

    L'équipe de maintenance des ponts roulants ST-HM-PR est souvent confrontée à résoudre des problèmes d'usure de galets de translation. Ces défauts apparaissent particulièrement lorsque l'on travaille avec des charges décentrées et sur des ponts roulants de grande portée. Pour remédier à ces défauts, plutôt que d'utiliser une solution mécanique conventionnelle, le groupe HM a développé un système électronique qui consiste à mesurer la distance entre le rail de roulement et les joues des roues, traiter ce signal et corriger la vitesse des moteurs respectifs de translation, de façon à maintenir le pont roulant centré. Ce système a été entièrement réalisé au sein du groupe HM et installé sur deux ponts roulants équipant le hall EHN1.

  10. Ciudadanía ecológica

    Directory of Open Access Journals (Sweden)

    Dobson, Andrew

    2005-06-01

    de los otros dos tipos de ciudadanía. Este artículo explora el modo en que la ciudadanía ecológica completa la arquitectura general de la ciudadanía, antes de perfilar la importancia de la ciudadanía ecológica para el objetivo de lograr el desarrollo sostenible.

  11. Administrative Circular No. 14 (Rev. 2)

    CERN Document Server

    HR Department

    2007-01-01

    The HR Department wishes to draw the attention of members of the personnel to a number of amendments to Administrative Circular No. 14 (Rev. 2) entitled "Protection of members of the personnel against the financial consequences of illness, accident and disability" which came into force on 1st July 2006 (cf. Weekly Bulletin of 14 and 21 August 2006). Occupational Accident Declaration Form (HS50) https://cern.ch/service-procedures/AdminMan/Forms/HS50E.doc •\tIt must be completed within 10 working days of the date on which the accident occurred (§ 29.2.1), unless the person concerned is materially unable to meet this deadline. • The completed formula must be accompanied by a medical certificate giving details of any bodily injuries resulting from the accident (Annex 1, § 5). The medical certificate must be obtained from the doctor who has been consulted for that purpose. Benefits resulting from illnesses and accidents Medical treatment will cease to be reimbursed under ...

  12. Gouvernance des systèmes alimentaires urbains pour la prévention ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... contre ces systèmes alimentaires en évolution et l'augmentation connexe des maladies ... les systèmes d'information et d'enregistrement des faits d'état civil dans les pays en ... GrowInclusive : la plateforme tant attendue est en construction.

  13. Analyste de systèmes intermédiaire (h/f) | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'analyste de systèmes intermédiaire travaille sous la supervision du ... à la mise en œuvre et à la maintenance d'un large éventail de systèmes tout en assurant ... directement les consultants externes sous contrat afin de faciliter la transition ...

  14. Systèmes d'information sanitaire ou santé sexuelle et reproductive ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    23 mai 2017 ... Systèmes d'information sanitaire ou santé sexuelle et reproductive des adolescents en Afrique de l'Ouest. Appel. Propositions. Programme(s) ... Sujet(s). Systèmes de santé, ADOLESCENTS, SANTÉ REPRODUCTIVE, DROITS EN MATIERE DE PROCREATION. Durée. 36 à 48 mois. Financée par. CRDI ...

  15. Influence du système d'élevage sur la reproduction de la poule ...

    African Journals Online (AJOL)

    SARAH

    améliorer la productivité des poules locales. Le nombre d'œufs pondu par poule et par an dans ce système a été plus du ... moderne de poulet de chair, de poules pondeuses ..... conditionnée plus par le système de conduite et la.

  16. L’Ecole Sucrière Belge de Glons

    Directory of Open Access Journals (Sweden)

    Hendrik Deelstra

    2008-09-01

    Full Text Available The Belgian sugar school of Glons This article deals with the start in 1889 and the evolution till 1914 of the first Sugar technical school in Belgium located in Glons-Liège. In the literature on the history of sciences in Belgium this school has been unjustly neglected or forgotten. This is probably due to the total destruction of the archives in 1917 by the German occupiers. The history of the creation of a School for sugar chemists and technicians goes back to the early 1880’s, when the need was realised for the creation of such a High Technical School, to support and improve the most important agro-industrial industry in Belgium: the beet-sugar production. However there was at that time no consensus how to create and organize such an Institute. In 1889, E. Nihoul started in Glons a private sugar technical school for the direct training of specialists for all functions in the sugar industry, especially that of sugar chemists. This article describes the history of this school from 1889 till 1914. The school rapidly gained a great reputation and became extremely attractive for students outside Belgium. During the period 1900 till 1914 the school produced 251 qualified specialists of which 80% were foreigners. The school moved to Liège in 1917 and after 1932 involved in fusions with different Technical High Schools to form the now well-known ‘Hautes Ecoles Rennequin Sualem’ in Liège.

  17. ECOLE DE RUGBY DE CERN / MEYRIN / ST-GENIS

    CERN Multimedia

    RUGBY CLUB

    2010-01-01

    La période de rentrée des classes coïncide également avec la reprise des activités sportives de nos enfants. L’Ecole de Rugby du CMSG Rugby Club, une des plus grandes de Suisse avec près d’une de licenciés de 6 à 18 ans, profite de cette période pour vous informer sur la réelle alternative que représente le Rugby. Pourquoi le rugby pour mon enfant ? Parce qu’il contribue à l’épanouissement harmonieux des enfants et des jeunes, ainsi qu’à la formation de leur personnalité. C’est même le ‘Sport Collectif par Excellence’ selon le Manuel des Castor Juniors ! Le rugby est un sport complet qui sollicite et développe les capacités motrices, intellectuelles, sociales et affectives de celui qui l’exerce. Le rugby...

  18. Biallelic inactivation of REV7 is associated with Fanconi anemia.

    Science.gov (United States)

    Bluteau, Dominique; Masliah-Planchon, Julien; Clairmont, Connor; Rousseau, Alix; Ceccaldi, Raphael; Dubois d'Enghien, Catherine; Bluteau, Olivier; Cuccuini, Wendy; Gachet, Stéphanie; Peffault de Latour, Régis; Leblanc, Thierry; Socié, Gérard; Baruchel, André; Stoppa-Lyonnet, Dominique; D'Andrea, Alan D; Soulier, Jean

    2016-09-01

    Fanconi anemia (FA) is a recessive genetic disease characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure (BMF), and a strong predisposition to cancer. Twenty FA genes have been identified, and the FANC proteins they encode cooperate in a common pathway that regulates DNA crosslink repair and replication fork stability. We identified a child with severe BMF who harbored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), which encodes the mutant REV7 protein REV7-V85E. Patient-derived cells demonstrated an extended FA phenotype, which included increased chromosome breaks and G2/M accumulation upon exposure to DNA crosslinking agents, γH2AX and 53BP1 foci accumulation, and enhanced p53/p21 activation relative to cells derived from healthy patients. Expression of WT REV7 restored normal cellular and functional phenotypes in the patient's cells, and CRISPR/Cas9 inactivation of REV7 in a non-FA human cell line produced an FA phenotype. Finally, silencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA repair defect underlies the development of BMF in FA. Taken together, our genetic and functional analyses identified REV7 as a previously undescribed FA gene, which we term FANCV.

  19. Analysis of translesion DNA synthesis activity of the human REV1-REV7 complex, which is a key player in radiation-induced mutagenesis

    International Nuclear Information System (INIS)

    Masuda, Y.; Masuda, K.; Kamiya, K.

    2003-01-01

    Full text: Ionizing radiation frequently causes oxidative DNA damage in cells. It has been suggested that functions of the REV1 and REV7 genes are induction of mutations and prevention of cell death caused by ionizing radiation. With yeast Saccharomyces cerevisiae, results from a variety of investigations have demonstrated that the REV genes play a major role in induction of mutations through replication processes which directly copy the damaged DNA template during DNA replication. However, in higher eucaryotes, functions of homologues are poorly understood and appear somewhat different from the yeast case. It has been suggested that human REV1 interacts with human REV7, this being specific to higher eucaryotes. Here we show that purified human REV1 and REV7 proteins form a heterodimer in solution, which is stable through intensive purification steps. Results from biochemical analysis of the transferase reactions of the REV1-REV7 complex demonstrated, in contrast to the case of yeast Rev3 whose polymerase activity is stimulated by assembly with yeast Rev7, that human REV7 did not influence the stability, substrate specificity or kinetic parameters of the transferase reactions of REV1 protein. A possible molecular role of the REV7 subunit may be to help assembly of the REV1 protein to a large complex containing REV3 and/or other DNA polymerases in higher eucaryotes

  20. Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging

    International Nuclear Information System (INIS)

    Wolff, Horst; Hadian, Kamyar; Ziegler, Manja; Weierich, Claudia; Kramer-Hammerle, Susanne; Kleinschmidt, Andrea; Erfle, Volker; Brack-Werner, Ruth

    2006-01-01

    The human immunodeficiency virus Rev protein is a post-transcriptional activator of HIV gene expression. Rev is a nucleocytoplasmic shuttle protein that displays characteristic nuclear/nucleolar subcellular localization in various cell lines. Cytoplasmic localization of Rev occurs under various conditions disrupting Rev function. The goal of this study was to investigate the relationship between localization of Rev and its functional activity in living cells. A triple-fluorescent imaging assay, called AQ-FIND, was established for automatic quantitative evaluation of nucleocytoplasmic distribution of fluorescently tagged proteins. This assay was used to screen 500 rev genes generated by error-prone PCR for Rev mutants with different localization phenotypes. Activities of the Rev mutants were determined with a second quantitative, dual-fluorescent reporter assay. In HeLa cells, the majority of nuclear Rev mutants had activities similar to wild-type Rev. The activities of Rev mutants with abnormal cytoplasmic localization ranged from moderately impaired to nonfunctional. There was no linear correlation between subcellular distribution and levels of Rev activity. In astrocytes, nuclear Rev mutants showed similar impaired activities as the cytoplasmic wild-type Rev. Our data suggest that steady-state subcellular localization is not a primary regulator of Rev activity but may change as a secondary consequence of altered Rev function. The methodologies described here have potential for studying the significance of subcellular localization for functions of other regulatory factors

  1. El sector de los alimentos ecológicos: Regulación y etiquetado ecológico = The organic food sector: Regulation and ecological labeling

    Directory of Open Access Journals (Sweden)

    María Belén Aguirre García

    2016-06-01

    Full Text Available El sector de los alimentos ecológicos y la evolución de su normativa están experimentando continuos cambios y ampliaciones acordes con los flujos económicos y comerciales de nuestros días. El objetivo del artículo, desde una metodología descriptiva, es reflejar esta evolución, presentando la regulación vigente, que es exhaustiva y abarca ámbitos diversos: sistemas de producción agraria ecológica, control y certificación de operadores, comercialización y etiquetado de los alimentos ecológicos. Asimismo, se abordan las diferentes caracterizaciones en la actualidad del etiquetado de los alimentos ecológicos en Europa, en España y en las Comunidades Autónomas.   The organic food sector and the evolution of its regulations are undergoing continuous changes and extensions in line with the economic and commercial flows of our day. The objective of the article, from a descriptive methodology, is to reflect this evolution, presenting the current regulation, which is exhaustive and covers different areas: ecological agricultural production systems, operator control and certification, marketing and labeling of organic food. It also addresses the different characterizations of organic food labeling in Europe, Spain and the “Comunidades Autónomas”.

  2. Wave power plant at Horns Rev. Screening[Denmark]; Boelgekraftanlaeg ved Horns Rev. Screening

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Hans C.; Nielsen, Kim; Steenstrup, P.R.; Friis-Madsen, E.; Wigant, L.

    2005-12-15

    The objective for the analysis has been to establish data for the sea at Horns Rev wind farm in the North Sea in order to assess the opportunity for using the site as test site for demonstration of wave energy devices exemplified by three different devices under development in Denmark. For comparison alternative sites like Hanstholm, Samsoe and Nissum Bredning are also assessed as well as the test centre EMEC at the Orkney Islands and the proposed test site Wave Hub at the north coast of Cornwall. The analysis shows that it is possible without major technical problems to connect 2-4 MW power generated by 3 different wave energy devices (AquaBuOY, Wave Star Energy and Wave Dragon) to the wind farm at Horns Rev (www.hornsrev.dk). The expenses for connection and regulation within the wind farm is about 200,000 DKK (30,00 EURO). On top of this comes the cost for individual sub sea cable connection to the wave devices, pull in of the sub sea cable through the existing J-tube in turbine T04 and the necessary regulation/control system in the individual wave devices to avoid damaging the power system in case of too high production. The analysis of the co-production of wind and wave power is dealt with in a separate report which shows that over a time period of half to one hour the time variation for wind generated electricity is 3 times as large as for wave energy generated power based on the actual measurement at Horns Rev. Further on the analysis shows that the wave generated power is more predictable than wind energy generated power as the power from the waves first is present about 2 hours after the wind is acting and last for 3 to 6 hours after the wind dies out; 6 to 12 hours with wind from west. The time is off course strongly depending of the direction of the wind i.e. the fetch. As this special report has a more general scope than the analysis as such it is reported in English (Annex Report II). The analysis shows that it is up to the individual device developer

  3. A temática ambiental e o ensino de biologia: o professor enquanto sujeito ecológico

    OpenAIRE

    Campos, Daniela Bertolucci de [UNESP

    2007-01-01

    Professores são potencialmente educadores ambientais no ensino formal, mas para que atuem como tal é necessário que ocorra um processo de identificação pessoal e profissional com o ambiental durante a sua trajetória de vida. Segundo Carvalho (2004), professores que passam a cultivar idéias e sensibilidades ecológicas em sua prática educativa estão sendo portadores dos ideais do sujeito ecológico. O sujeito ecológico representa um tipo ideal, que possui um conjunto de atributos e valores ecoló...

  4. Analysis of the Cochrane Review: Omega-3 Fatty Acids for the Treatment of Dementia. Cochrane Database Syst Rev. 2016;4:CD009002.

    Directory of Open Access Journals (Sweden)

    David Cordeiro Sousa

    2017-10-01

    Full Text Available Dietary supplementation with omega-3 polyunsaturated fatty acids from fish and plant sources is commonly prescribed as a nonfarmacological alternative to improve brain functions and slow down the progression of dementia. This use is mostly based on findings of preclinical studies which established the role of omega-3 polyunsaturated fatty acids in the development and integrity of the brain, as well as epidemiological research that found evidence of malnutrition in patients with dementia. This Cochrane systematic review included three randomized, placebo-controlled trials at low risk of bias, in which omega-3 polyunsaturated fatty acids were administered to people with mild to moderate Alzheimer’s disease in the form of supplements. Of the main results of this systematic review we highlight the lack of convincing evidence for the efficacy of omega-3 polyunsaturated fatty acids supplementation in the treatment of patients with Alzheimer’s disease, as well as the low frequency of reported adverse events, with a comparable overall frequency between omega-3 polyunsaturated fatty acids and the placebo groups. The effects on other populations with dementia remain unclear. This paper aims to summarize and discuss the main results and conclusions of this systematic review, as well as its implications for the daily clinical practice.

  5. Administrative Circular N° 26 (Rev.  5) - November 2004

    CERN Multimedia

    Human Resources Department

    2004-01-01

    Procedure governing the career evolution of staff members The introduction of an electronic individual appraisal report form via EDH for the MAPS exercise entails some modifications to Administrative Circular N° 26 (Rev. 4). The revised version (Rev. 5) is available in departmental secretariats as well as on the Web at the following address: http://cern.ch/hr-web/internal/admin_services/admincirc/listadmincirc.asp Human Resources Department Tel. 74128

  6. Altered Sleep Homeostasis in Rev-erbα Knockout Mice.

    Science.gov (United States)

    Mang, Géraldine M; La Spada, Francesco; Emmenegger, Yann; Chappuis, Sylvie; Ripperger, Jürgen A; Albrecht, Urs; Franken, Paul

    2016-03-01

    The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of several core clock genes, including Rev-erbα, is modulated by sleep loss. We here test the consequences of a loss of REV-ERBα on the homeostatic regulation of sleep. EEG/EMG signals were recorded in Rev-erbα knockout (KO) mice and their wild type (WT) littermates during baseline, sleep deprivation, and recovery. Cortical gene expression measurements after sleep deprivation were contrasted to baseline. Although baseline sleep/wake duration was remarkably similar, KO mice showed an advance of the sleep/wake distribution relative to the light-dark cycle. After sleep onset in baseline and after sleep deprivation, both EEG delta power (1-4 Hz) and sleep consolidation were reduced in KO mice indicating a slower increase of homeostatic sleep need during wakefulness. This slower increase might relate to the smaller increase in theta and gamma power observed in the waking EEG prior to sleep onset under both conditions. Indeed, the increased theta activity during wakefulness predicted delta power in subsequent NREM sleep. Lack of Rev-erbα increased Bmal1, Npas2, Clock, and Fabp7 expression, confirming the direct regulation of these genes by REV-ERBα also in the brain. Our results add further proof to the notion that clock genes are involved in sleep homeostasis. Because accumulating evidence directly links REV-ERBα to dopamine signaling the altered homeostatic regulation of sleep reported here are discussed in that context. © 2016 Associated Professional Sleep Societies, LLC.

  7. Webový systém pro skladovou evidenci

    OpenAIRE

    Češka, Petr

    2015-01-01

    Cílem diplomové práce je zhodnotit a vylepšit aktuální řešení informačního systému organizace Klub Salesiánského hnutí mládeže v Prostějově tak, aby splňoval náročnější požadavky na rychlou online komunikaci a vytvořil tak dostupnou podporu pro řízení informací a řízení skladových aktiv. Práce se zaměřuje na další návrhy rozšíření IS tak, aby se na jeho základech mohla organizace dále rozvíjet a plnit požadavky udávané stakeholdery. The aim of the diploma thesis is to evaluate and improve ...

  8. GPS sledovací systém

    OpenAIRE

    Hofman, Jan

    2010-01-01

    V práci je popsán základní princip a vlastnosti globálního pozičního systému GPS. Je zde přiblížena problematika určování polohy, rychlosti a nadmořské výšky. Tyto poznatky jsou dále použity pro návrh zařízení, které komunikuje s běžně vyráběným GPS přijímačem a z něj získané informace zpracovává a ukládá do paměti pro pozdější vyhodnocení The keystone and properties of Global Position System (GPS) are described in this thesis. The thesis explains questions of position, speed and elevation...

  9. Restauración ecológica en la meseta central de Costa Rica

    OpenAIRE

    Barrientos Llosa, Zaidett; Monge-Nájera, Julian

    2016-01-01

    Debido al impacto negativo del ser humano sobre los hábitats terrestres y acuáticos, actualmente es necesaria la restauración ecológica de hábitats degradados. Suele confundírsele con la reforestación y la sucesión natural. La restauración ecológica es una actividad tecnológica que recupera en un ecosistema dañado el suelo, el agua, el aire y las especies que lo habitaron originalmente. Resumimos los hallazgos aplicables a la restauración ecológica en Costa Rica, con énfasis en la Meseta Cent...

  10. Ladrillos ecológicos una estrategia didáctica

    OpenAIRE

    Leiva Deantonio, Dolly Elizabeth; Reyes Roncancio, Jaime Duván

    2017-01-01

    Se presentan los resultados de la investigación desarrollada para incorporar una conciencia-ecológica-práctica en relación con la utilidad de los envases plásticos y el empaque de productos alimenticios que se generan diariamente en una institución educativa pública de la ciudad de Bogotá. El proceso metodológico de corte cualitativo involucró la participación de los estudiantes en la exploración del tipo de desechos plásticos y su adaptación como ladrillos ecológicos, fomentando acciones con...

  11. Natureza, ecologia e cultura: bases para uma abordagem ao projeto ecológico

    OpenAIRE

    Silva, Paula Gomes da

    2013-01-01

    A sensibilidade ao contexto natural, mais tarde identificado como contexto ecológico, constitui um aspecto fundamental da arquitectura paisagista. Simultaneamente, a criação de espaços de paisagem como produto cultural, motivado e apreciado no âmbito de convenções estéticas é também uma das características fundamentais da profissão. A dupla ligação à natureza (ciência) e à cultura (arte) tem sido motivadora de profundos conflitos. O projecto ecológico, que se consolidou como uma corrente proj...

  12. Una mirada actual del modelo ecológico de Florence Nightingale

    OpenAIRE

    Germán-Bes, Concepción

    2011-01-01

    Introducción: La celebración del centenario de Florence Nightingale y la iniciativa de la Fundación Index de la lectura continuada en voz alta, nos ha permitido reflexionar en la obra “Notas de Enfermería”, cuyo objetivo se ha centrado en los contenidos ecológicos de la misma. Método: Realizamos un “análisis de contenido” del texto buscando lo ecológico y ambiental y se han contrastado con las posibles influencias o concordancia con autores de su época y con lo que son hoy los conceptos de sa...

  13. Soutien au programme de recherche du GCRAI sur les systèmes d ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Plus de 700 millions de personnes dépendent de systèmes d'aquaculture pour gagner leur vie. Ces systèmes agricoles diversifiés combinent culture, élevage, aquaculture, pêche et collecte de ressources naturelles comme les fruits, les graines, le bois et la faune. Toutefois, de nombreuses contraintes empêchent les petits ...

  14. Schéma directeur des Systèmes d'information 2012-2016

    OpenAIRE

    Institut National de Recherche Agronomique UAR 0776 Administration du siège

    2012-01-01

    Le schéma directeur des systèmes d’information de l’inra est le premier Schéma directeur dont l’institut se dote dans le champ des systèmes D’information. Il couvre la période 2012‐2016 du contrat d’objectifs Et s’inscrit dans les perspectives scientifiques dressées par le document D’orientation 2010‐2020

  15. Un système multi-agents pour le filtrage automatique du courrier ...

    African Journals Online (AJOL)

    Cet article montre l'applicabilité et l'adaptabilité de l'appriche intelligence artificielle distribuée, en l'occurrence les systèmes multi-agnets, au filtrage du courrier électronique. Il décrit un système de filtrage de courriers électroniques dynamiques et intelligent (SYMCOL). Il permet de traiter la partie structurée et la partie texte ...

  16. Binding and thermodynamics of REV peptide-ctDNA interaction.

    Science.gov (United States)

    Upadhyay, Santosh Kumar

    2017-03-01

    The thermodynamics of DNA-ligand binding is important as it provides useful information to understand the details of binding processes. HIV-1 REV response element (RRE) located in the env coding region of the viral genome is reported to be well conserved across different HIV-1 isolates. In this study, the binding characteristics of Calf thymus DNA (ctDNA) and REV peptide from HIV-1 were investigated using spectroscopic (UV-visible, fluorescence, and circular dichroism (CD)) and isothermal titration calorimetric (ITC) techniques. Thermal stability and ligand binding properties of the ctDNA revealed that native ctDNA had a T m of 75.5 °C, whereas the ctDNA-REV peptide complex exhibited an incremental shift in the T m by 8 °C, indicating thermal stability of the complex. CD data indicated increased ellipticity due to large conformational changes in ctDNA molecule upon binding with REV peptide and two binding stoichiometric modes are apparent. The ctDNA experienced condensation due to large conformational changes in the presence of REV peptide and positive B→Ψ transition was observed at higher molar charge ratios. Fluorescence studies performed at several ligand concentrations revealed a gradual decrease in the fluorescence intensity of EtBr-bound ctDNA in response to increasing ligand concentrations. The fluorescence data further confirmed two stoichiometric modes of binding for ctDNA-REV peptide complex as previously observed with CD studies. The binding enthalpies were determined using ITC in the temperature range of 293 K-308 K. The ITC binding isotherm was exothermic at all temperatures examined, with low ΔH values indicating that the ctDNA-REV peptide interaction is driven largely by entropy. The heat capacity change (ΔC p ) was insignificant, an unusual finding in the area of DNA-peptide interaction studies. The variation in the values obtained for ΔH, ΔS, and ΔG with temperature further suggests that ctDNA-REV peptide interaction is entropically

  17. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-01-01

    The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised.

  18. Administrative Circular No. 26 (Rev. 9) – Recognition of Merit

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 26 (Rev. 9) entitled "Recognition of Merit”, approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 September 2011 is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp The circular was above all revised in order to integrate the new CERN Competency Model into the annual procedure of performance appraisal. It cancels and replaces Administrative Circular No. 26 (Rev. 8) entitled "Recognition of merit” of September 2008. Department Head Office HR Department

  19. Administrative Circular No. 26 (Rev. 7) – May 2007

    CERN Multimedia

    HR Department

    2007-01-01

    Recognition of Merit of Staff Members Administrative Circular No. 26 (Rev. 7) is now available on the intranet site of the Human Resources Department. This circular cancels and replaces Administrative Circular No. 26 (Rev. 6) - Procedures governing the career development of staff members. Copies will shortly be available in Departmental secretariats. If you require any additional information on the new staff-member merit assessment and recognition system, you may consult the FAQ, which has been available on the Human Resources Department intranet site since February 2007. Human Resources Department Tel. 78003

  20. From "Ecoles Superieures de Commerce" to "Management Schools": Transformations and Continuity in French Business Schools

    Science.gov (United States)

    Blanchard, Marianne

    2009-01-01

    Part of the national system of grandes Ecoles, French Business schools have known radical changes since the 1980s, notably in size, and have become more attractive to students both at a national and an international level. As a consequence, the French elitist system has been questioned by the competition of foreign--especially Anglo-Saxon--models.…

  1. Promoting Students' Emotions and Achievement--Instructional Design and Evaluation of the ECOLE-Approach

    Science.gov (United States)

    Glaser-Zikuda, Michaela; Fuss, Stefan; Laukenmann, Matthias; Metz, Kerstin; Randler, Christoph

    2005-01-01

    Emotions such as interest and anxiety are part of the learning process as well as cognition and motivation. In view of this, educational science should take emotional aspects of instruction into account. The "ECOLE"-approach ("Emotional and Cognitive Aspects of Learning") presented in this paper is a theoretically guided…

  2. IsoBank workshop held at IsoEcol10 - University of Tokyo 2016

    OpenAIRE

    Hayden, Brian

    2016-01-01

    IsoBank is a repository for stable isotope values and relevant metadata. These slides were presented at a workshop held during IsoEcol10 to refine and design the IsoBank for the needs of a diverse group of researchers.

  3. Amélioration du système de suivi de l'information sur la santé ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le système de suivi de l'information sur la santé communautaire (CHITS) est un système électronique d'information sur la santé publique mis en place par les services de santé de Pasay City en 2004. Le cinquième des habitants des bidonvilles du grand Manille étant établis à Pasay City, ce système dessert une population ...

  4. Marco para el análisis del tema ecológico en la literatura venezolana

    OpenAIRE

    María De los Ángeles Martín Hernández

    2016-01-01

    El propósito del artículo es sistematizar las premisas teóricas que constituyen la base fundamental para el abordaje analítico de los textos literarios con tema ecológico. Se conjugan y sintetizan los planteamientos hallados en la revisión bibliográfica realizada, relacionados con definiciones y caracterizaciones de la vinculación actividad literaria-tema ecológico en el contexto venezolano; se organizan consideraciones que explican la adopción del adjetivo “ecológico” y las vinculaciones eco...

  5. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-03-14

    Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein) as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  6. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

    Directory of Open Access Journals (Sweden)

    Sheehy Noreen

    2011-03-01

    Full Text Available Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  7. Aplikace pro nositelnou elektroniku se systémem Android Wear

    OpenAIRE

    Šmejkal, Petr

    2017-01-01

    Semestrální práce „Aplikace pro nositelnou elektroniku se systémem" Android Wear popisuje základní principy komunikačních sítí - M2M (machine to machine), H2H (human to human) a D2D (device to device). Práce se dále zabývá nositelnými zařízeními, zejména chytrými hodinkami, dostupnými operačními systémy pro chytré hodinky a systémem Android, Android Wear. V praktické části je popsaná funkcionalita, vzhled a struktura vyvinuté aplikace pro Android Wear. The semestral project "Application fo...

  8. Informační systém pro předprodej vstupenek

    OpenAIRE

    Galetka, Josef

    2007-01-01

    Práce se zabývá problematikou spojenou s návrhem a implementací informačního systému pro předprodej vstupenek. Systém umožňuje prodej a nákup vstupenek na různé akce. Je schopen generovat a zasílat vstupenky elektronicky. Je zahrnuta administrátorská správa systému a požadované uživatelské prostředky. Implementace byla realizována za použití technologie PHP, MySQL a JavaScript na serveru Apache. This work deals with the problems connected with projection and implementation of information s...

  9. Inteligentní přístupový systém

    OpenAIRE

    Steingart, Viktor

    2017-01-01

    Práce se zabývá tvorbou autonomního vestavěného systému sloužícího jako přístupový systém postaveném na platformě ESP8266. Systém umožňuje přístup správce do administrátorského webového rozhraní pomocí mobilního telefonu. This thesis deals with the creation of an autonomous embedded system serving as an access control system built on the platform ESP8266. The system allows administrator access to the admin web interface via a mobile phone. B

  10. La systématique de l’esprit pratique chez Wolff, Kant, Fichte et Hegel

    OpenAIRE

    Siep, Ludwig

    2011-01-01

    En dépit des grands bouleversements systématiques dans la philosophie allemande du xviiie siècle, la continuité est étonnante, de Wolff à Hegel, pour ce qui concerne le contenu des doctrines sur la raison pratique. Une comparaison de ces doctrines chez Wolff, Kant, Fichte et Hegel peut révéler l’intention et les raisons pour lesquelles chacun de ces auteurs modifia la systématique des différentes facultés. À partir de Kant, autonomie et liberté deviennent les concepts directeurs permettant de...

  11. A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev

    International Nuclear Information System (INIS)

    Fang Jianhua; Kubota, Satoshi; Yang Bin; Zhou Naiming; Zhang Hui; Godbout, Roseline; Pomerantz, Roger J.

    2004-01-01

    HIV-1 Rev escorts unspliced viral mRNAs out of the nucleus of infected cells, which allows formation of infectious HIV-1 virions. We have identified a putative DEAD box (Asp-Glu-Ala-Asp) RNA helicase, DDX1, as a cellular co-factor of Rev, through yeast and mammalian two-hybrid systems using the N-terminal motif of Rev as 'bait'. DDX1 is not a functional homolog of HIV-1 Rev, but down-regulation of DDX1 resulted in an alternative splicing pattern of Rev-responsive element (RRE)-containing mRNA, and attenuation of Gag p24 antigen production from HLfb rev(-) cells rescued by exogenous Rev. Co-transfection of a DDX1 expression vector with HIV-1 significantly increased viral production. DDX1 binding to Rev, as well as to the RRE, strongly suggest that DDX1 affects Rev function through the Rev-RRE axis. Moreover, down-regulation of DDX1 altered the steady state subcellular distribution of Rev, from nuclear/nucleolar to cytoplasmic dominance. These findings indicate that DDX1 is a critical cellular co-factor for Rev function, which maintains the proper subcellular distribution of this lentiviral regulatory protein. Therefore, alterations in DDX1-Rev interactions could induce HIV-1 persistence and targeting DDX1 may lead to rationally designed and novel anti-HIV-1 strategies and therapeutics

  12. Tècniques de maneig de pomera (Malus domestica Borkhausen) en agricultura ecològica

    OpenAIRE

    Alins Valls, Georgina

    2009-01-01

    En la darrera dècada, la superfície en agricultura ecològica a Europa ha experimentat unfort augment, però la producció de fruita dolça encara no arriba a l'1% de la producció totaldegut a les dificultats tècniques que comporta. La producció de pomes en agricultura ecològica planteja tota una sèrie de reptes com l'elecció de la varietat, el control de plagues, malalties i flora arvense i l'aclarida, entre altres. El treball realitzat en aquesta tesi ha tingut com a objectiu incrementar el con...

  13. Operational circular No. 1 (Rev. 1) – Operational circulars

    CERN Multimedia

    HR Department

    2011-01-01

    Operational Circular No. 1 (Rev. 1) is applicable to members of the personnel and other persons concerned. Operational Circular No. 1 (Rev. 1) entitled "Operational circulars", approved following discussion at the Standing Concertation Committee meeting on 4 May 2011, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 1 entitled "Operational Circulars” of December 1996. This new version clarifies, in particular, that operational circulars do not necessarily arise from the Staff Rules and Regulations, and the functional titles have been updated to bring them into line with the current CERN organigram. Department Head Office  

  14. Administrative Circular No. 26 (Rev.10) - Recognition of merit

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 26 (Rev. 10) entitled “Recognition of Merit”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to staff members. It cancels and replaces Administrative Circular No. 26 (Rev. 9) entitled “Recognition of Merit” of December 2011. The circular was revised in order to take into account the work performed in the framework of an elective mandate during the exercise of merit recognition of staff members. In addition, the circular was revised to provide that, in the case of staff members on special leave for professional reasons for a period equal to or longer than half a year, it will no longer be possible to grant an exceptional advancement. Department Head Office HR Department

  15. Administrative Circular No. 23 (Rev. 4) - Special working hours

    CERN Document Server

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 23 (Rev. 4) entitled "Special working hours", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208539.   This revised circular cancels and replaces Administrative Circular No. 23 (Rev. 3) also entitled "Special working hours" of January 2013. This document contains modifications to reflect the new career structure and ensuring the provision consistent with practice that compensation or remuneration of special working hours performed remotely is possible only in case of emergency.   This circular will enter into force on 1st September 2016.

  16. Meteorological explanation of wake clouds at Horns Rev wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Emeis, S. [Karlsruhe Institute of Technology (Germany). Inst. for Meteorology and Climate Research

    2010-08-15

    The occurrence of wake clouds at Horns Rev wind farm is explained as mixing fog. Mixing fog forms when two nearly saturated air masses with different temperature are mixed. Due to the non-linearity of the dependence of the saturation water vapour pressure on temperature, the mixed air mass is over-saturated and condensation sets in. On the day in February 2008, when the wake clouds were observed at Horns Rev, cold and very humid air was advected from the nearby land over the warmer North Sea and led to the formation of a shallow layer with sea smoke or fog close above the sea surface. The turbines mixed a much deeper layer and thus provoked the formation of cloud trails in the wakes of the turbines. (orig.)

  17. Bajo el signo del miedo ecológico global: la imbricación de lo sagrado en la conciencia ecológica europea

    Directory of Open Access Journals (Sweden)

    Jose Manuel Echavarren

    2010-01-01

    Full Text Available La situación de crisis ecológica actual ha provocado un clima de miedo que afecta a amplios sectores de la sociedad. En el presente artículo se estudia cómo el miedo medioambiental influye en las actitudes y prácticas ecocéntricas por parte de la población europea, y cómo se imbrica a su vez con una interpretación sagrada del medio. La religión se puede considerar una respuesta cultural a miedos colectivos, y aquí se analiza cómo reacciona ante los nuevos miedos medioambientales del cambio de siglo. En particular interesa el caso de la ecorreligiosidad de nuevo cuño denominada por Giner y Tàbara Piedad Cósmica. Los datos se extraen de la encuesta ISSP Environment del año 2000, trabajando sobre una muestra de trece países europeos. Los resultados muestran que el miedo medioambiental es un activador de la conducta ecológica y que la Piedad Cósmica en particular destaca por su compromiso medioambiental.

  18. A sustentabilidade ecológica do consumo em Minas Gerais: uma aplicação do método da pegada ecológica

    Directory of Open Access Journals (Sweden)

    Marcos Henrique Godoi Gonzalez

    2016-02-01

    Full Text Available Embora sejam intensas as preocupações com o desenvolvimento sustentável, escassas são as tentativas de se mensurá-lo entre as unidades subnacionais no Brasil. Com o intuito de contribuir para o preenchimento dessa lacuna, este trabalho tem como objetivo principal analisar a sustentabilidade ecológica do consumo da população do Estado de Minas Gerais no ano de 2008 por meio do cálculo de sua pegada ecológica. A análise se baseia nas contribuições mais recentes para tal metodologia, buscando comparar o impacto local e a disponibilidade global de recursos. Concluiu-se que, apesar de estar dentro da própria capacidade de suporte do Estado, em termos per capita, a demanda absoluta por capital natural gera uma pressão excessiva quando comparada à disponibilidade mundial de capital natural, uma vez que, caso a população de todo o mundo mantivesse o mesmo padrão de consumo dos mineiros, seriam necessários 2,64 planetas Terra para sustentá-la.

  19. REV-ERB and ROR: therapeutic targets for treating myopathies

    Science.gov (United States)

    Welch, Ryan D.; Flaveny, Colin A.

    2017-08-01

    Muscle is primarily known for its mechanical roles in locomotion, maintenance of posture, and regulation of cardiac and respiratory function. There are numerous medical conditions that adversely affect muscle, myopathies that disrupt muscle development, regeneration and protein turnover to detrimental effect. Skeletal muscle is also a vital secretory organ that regulates thermogenesis, inflammatory signaling and directs context specific global metabolic changes in energy substrate preference on a daily basis. Myopathies differ in the causative factors that drive them but share common features including severe reduction in quality of life and significantly increased mortality all due irrefutably to the loss of muscle mass. Thus far clinically viable approaches for preserving muscle proteins and stimulating new muscle growth without unwanted side effects or limited efficacy has been elusive. Over the last few decades, evidence has emerged through in vitro and in vivo studies that suggest the nuclear receptors REV-ERB and ROR might modulate pathways involved in myogenesis and mitochondrial biogenesis. Hinting that REV-ERB and ROR might be targeted to treat myopathies. However there is still a need for substantial investigation into the roles of these nuclear receptors in in vivo rodent models of degenerative muscle diseases and acute injury. Although exciting, REV-ERB and ROR have somewhat confounding roles in muscle physiology and therefore more studies utilizing in vivo models of skeletal muscle myopathies are needed. In this review we highlight the molecular forces driving some of the major degenerative muscular diseases and showcase two promising molecular targets that may have the potential to treat myopathies: ROR and REV-ERB.

  20. ENDF/B-5 Fission Products Library. Rev. 2

    International Nuclear Information System (INIS)

    Schwerer, O.; Pronyaev, V.G.; Lemmel, H.D.

    1984-07-01

    This document summarizes contents and documentation of the 1984 version of the Fission Products Nuclear Data File of the ENDF/B-5 Library (Rev. 2) maintained by the National Nuclear Data Center (NNDC) at the Brookhaven National Laboratory, USA. This file contains numerical neutron reaction data and decay data for 877 fission product nuclides. The entire file or selective retrievals from it can be obtained on magnetic tape from the IAEA Nuclear Data Section. (author)

  1. Una filosofía ecológica en Rodolfo Kusch

    Directory of Open Access Journals (Sweden)

    Henry Armando Alfonso Salgado

    2010-01-01

    Full Text Available En su obra filosófica, el pensador argentino Rodolfo Kusch busca desentrañar el pensamiento del indígena y del campesino para poner en evidencia ese aferrado espíritu ecológico de América que está tan arraigado al suelo y a la vida. El suelo no se reduce a los cuatro puntos cardinales, tampoco se divide en suelos diferentes (el suelo es la extensión, sino que indica la situación, anclada en la categoría de “estar”, en la tierra. El pensamiento ecológico de América debe buscarse como una raíz muy profunda sin utilizar la fuerza, puesto que la vida se encuentra arraigada en lo más profundo de la tierra y no debe arrancarse por mediaciones que desnaturalicen los procesos mis- mos de estar en la tierra. De esta forma, el pensar ecológico-cosmológico se convierte en la matriz o en el fundamento de toda una filosofía cosmológica indígena que, a su vez, es la gestora de otras estructuras como la política, la arquitectura, la economía, la religión y otros ámbitos de su organización cultural, bien sea como imperio, civilización o comunidad organizada. Así su concepción cósmica-ecológica es la base o raíz que nace de la semilla sobre la cual se gestan los principales imperios americanos.

  2. Redescubriendo El suelo: Su importancia ecológica y agrícola

    Directory of Open Access Journals (Sweden)

    Noé Manuel Montaño

    2016-10-01

    Full Text Available Redescubriendo el suelo: su importancia ecológica y agrícola es un libro muy completo, actualizado y sin duda será de consulta obligada para quienes hacen investigación edafológica y como material elemental para los cursos de pre- y posgrado de suelo y materias afines, tanto en México como en América Latina.

  3. Aportaciones de las percepciones socio-ecológicas a la Educación Ambiental

    Directory of Open Access Journals (Sweden)

    María del Socorro Aguilar Cucurachi

    2017-01-01

    Full Text Available En el actual contexto de crisis socio-ecológica surge la necesidad de analizar cómo los grupos humanos le damos significado a la naturaleza, siendo éste el principal objetivo en el estudio de las percepciones. Por su parte, la Educación Ambiental emerge para hacer frente a la crisis actual, al promover actitudes y valores para mitigar sus consecuencias y buscar soluciones. Ante este propósito, estudiar las percepciones constituye un proceso pertinente para comprender las realidades afectadas, así como para construir y evaluar procesos educativos. Argumentamos que el estudio de las percepciones debe ser enmarcado dentro de un esquema interdisciplinario. El presente estudio apunta a tres formas en las que las percepciones contribuyen a la Educación Ambiental: 1 La Educación Ambiental como objeto perceptual y de análisis; 2 La Educación Ambiental, que desde su noción transformadora puede incidir como factor de influencia sobre las percepciones socio-ecológicas, y 3 Las percepciones como una herramienta pedagógica. Valorar las aportaciones del estudio de las percepciones al campo de la Educación Ambiental posibilita la construcción de procesos educativos significativos desde y para las diferentes realidades socio-ecológicas.

  4. Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

    Science.gov (United States)

    Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M

    2017-02-01

    HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide

  5. Administrative Circulars No. 12 A (Rev. 2) - "Education fees” and No. 12 B (Rev. 2) - “Education fees and language courses”

    CERN Multimedia

    2013-01-01

    Administrative Circulars No. 12 A (Rev. 2) entitled “Education fees” and No. 12 B (Rev. 2) entitled “Education fees and language courses”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, are available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 12 A (Rev. 2) is applicable to Staff Members (except former “Local Staff Members”) recruited before 1st January 2007. Administrative Circular No. 12 B (Rev. 2) is applicable to Staff Members recruited on or after 1st January 2007, to Fellows, to Scientific Associates, to Guest Professors and to former “Local Staff” recruited before 1st January 2007. They cancel and replace Administrative Circulars No. 12 A (Rev. 1/Corr.) entitled "Education fees” and No. 12 B (Rev. 1/Corr.) entitled “Edu...

  6. Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.

    Science.gov (United States)

    Bogerd, H P; Wiegand, H L; Yang, J; Cullen, B R

    2000-10-01

    Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor. Human endogenous retrovirus K, a family of ancient endogenous retroviruses that is not related to the exogenous retrovirus HIV-1, was recently shown to also encode a Crm1-dependent nuclear RNA export factor, termed K-Rev. Although HIV-1 Rev and K-Rev display little sequence identity, they share the ability not only to bind to Crm1 and to RNA but also to form homomultimers and shuttle between nucleus and cytoplasm. We have used mutational analysis to identify sequences in the 105-amino-acid K-Rev protein required for each of these distinct biological activities. While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export. Although several nonfunctional K-Rev mutants acted as dominant negative inhibitors of K-Rev-, but not HIV-1 Rev-, dependent RNA export, these were not defined by their inability to bind to Crm1, as is seen with HIV-1 Rev. In total, this analysis suggests a functional architecture for K-Rev that is similar to, but distinct from, that described for HIV-1 Rev and raises the possibility that viral RNA export mediated by the approximately 25 million-year-old K-Rev protein may require an additional cellular cofactor that is not required for HIV-1 Rev function.

  7. UV-induced reversion of his4 frameshift mutations in rad6, rev1, and rev3 mutants of yeast.

    Science.gov (United States)

    Lawrence, C W; O'Brien, T; Bond, J

    1984-01-01

    The UV-induced reversion of two his4 frameshift alleles was much reduced in rad6 mutants of Saccharomyces cerevisiae, an observation that is consistent with the hypothesis that RAD6 function is required for the induction of all types of genetic alteration in misrepair mutagenesis. The reversion of these his4 alleles, together with two others of the same type, was also reduced in rev1 and rev3 mutant strains; in these, however, the extent of the reduction varied considerably with test allele used, in a manner analogous to the results in these strains for base repair substitution test alleles. The general features of UV-induced frameshift and substitution mutagenesis therefore appear quite similar, indicating that they may depend on related processes. If this conclusion is correct, greater attention must be given to integrating models which account for the production of nucleotide additions and deletions into those concerning misrepair mutagenesis.

  8. Administrateur du système (h/f) | CRDI - Centre de recherches pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sous la supervision du gestionnaire, Infrastructure, sécurité et documents (ISD), ... et de la maintenance courants des divers systèmes d'infrastructure du Centre, ... techniques dans les régions et des techniciens sous contrat) pour fournir des ...

  9. Penser Système : Découvrir nos modèles d'organisation

    NARCIS (Netherlands)

    Bryan, B.; Goodman, M.; Schaveling, J.

    2011-01-01

    Pourquoi le travail s’accumule-t-il sur nos bureaux alors que nous travaillons de plus en plus? Parfois « nos solutions » aggravent nos problèmes. Comment pouvons-nous éviter ces paradoxes ? Penser système donne de nouvelles perspectives dans des situations complexes. Cela vous permettra de

  10. Mot du Directeur régional Pleins feux surla recherche des systèmes ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Gloria Lihemo

    Afrique sub-saharienne. Nous y parlons du travail que fait le. CRDI pour appuyer la recherche des systèmes sanitaires qui prend en compte une approche holistique, interdisciplinaire pour une meilleure santé. Le CRDI reconnaît ...

  11. Analyste de systèmes principal (h/f) | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'analyste de systèmes principal travaille sous la supervision du ... une analyse fonctionnelle élémentaire des exigences en parlant de la portée et de la raison ... et l'infrastructure en matière de TI tout en se mettant à la place des techniciens, ...

  12. Gestionnaire, Systèmes financiers (h/f) | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Examiner et évaluer les répercussions des mises à niveau de l'infrastructure du CRDI .... Analyste des systèmes de gestion ... Le titulaire du poste établit le lien nécessaire entre les activités fonctionnelles financières et administratives et les ...

  13. A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis.

    NARCIS (Netherlands)

    Emond-Rheault, Jean-Guillaume; Jeukens, Julie; Freschi, Luca; Kukavica-Ibrulj, Irena; Boyle, Brian; Dupont, Marie-Josée; Colavecchio, Anna; Barrere, Virginie; Cadieux, Brigitte; Arya, Gitanjali; Bekal, Sadjia; Berry, Chrystal; Burnett, Elton; Cavestri, Camille; Chapin, Travis K; Crouse, Alanna; Daigle, France; Danyluk, Michelle D; Delaquis, Pascal; Dewar, Ken; Doualla-Bell, Florence; Fliss, Ismail; Fong, Karen; Fournier, Eric; Franz, Eelco; Garduno, Rafael; Gill, Alexander; Gruenheid, Samantha; Harris, Linda; Huang, Carol B; Huang, Hongsheng; Johnson, Roger; Joly, Yann; Kerhoas, Maud; Kong, Nguyet; Lapointe, Gisèle; Larivière, Line; Loignon, Stéphanie; Malo, Danielle; Moineau, Sylvain; Mottawea, Walid; Mukhopadhyay, Kakali; Nadon, Céline; Nash, John; Ngueng Feze, Ida; Ogunremi, Dele; Perets, Ann; Pilar, Ana V; Reimer, Aleisha R; Robertson, James; Rohde, John; Sanderson, Kenneth E; Song, Lingqiao; Stephan, Roger; Tamber, Sandeep; Thomassin, Paul; Tremblay, Denise; Usongo, Valentine; Vincent, Caroline; Wang, Siyun; Weadge, Joel T; Wiedmann, Martin; Wijnands, Lucas; Wilson, Emily D; Wittum, Thomas; Yoshida, Catherine; Youfsi, Khadija; Zhu, Lei; Weimer, Bart C; Goodridge, Lawrence; Levesque, Roger C

    2017-01-01

    The Salmonella Syst-OMICS consortium is sequencing 4,500 Salmonella genomes and building an analysis pipeline for the study of Salmonella genome evolution, antibiotic resistance and virulence genes. Metadata, including phenotypic as well as genomic data, for isolates of the collection are provided

  14. Le renforcement des systèmes de santé | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    4 avr. 2013 ... Avec le soutien du CRDI, Walter Flores et une coalition dirigée par le Centro de Estudios para la Equidad y Gobernanza en los Sistemas de Salud ... Les briques et les clics sont importants; il est essentiel de disposer d'infrastructures convenables et de systèmes efficaces de gestion de l'information.

  15. Elaboration et Suivi des Budgets de Marketing Industriel: le Système ADVISOR

    OpenAIRE

    Choffray, Jean-Marie; Delabre, Gilles

    1982-01-01

    Cet article revoit les problèmes posés par l'élaboration et le suivi des budgets de marketing dans un environnement industriel. Il présente le système ADVISOR pour lequel nous avons développé un programme interactif adapté aux besoins des entreprises Françaises.

  16. Les systèmes alimentaires alternatifs face aux enjeux sanitaires

    OpenAIRE

    Touzard, Jean-Marc

    2012-01-01

    L’objet de la communication est de montrer comment la coexistence et la combinaison d’une diversité de système alimentaires est un trait de la globalisation et joue sur les enjeux, les pratiques, et les régulations sanitaires.

  17. Systèmes de recommandation et Recherche d'Information

    OpenAIRE

    Candillier , Laurent; Chai , Etienne; Delpech , Estelle

    2012-01-01

    National audience; Cet article traite de l'application des technologies de recommandation aux systèmes de Recherche d'Information. Nous y détaillons un cas d'application à la recherche de lieux à travers la présentation de l'annuaire Nomao.

  18. Sampling and estimation techniques for the implementation of new classification systems: the change-over from NACE Rev. 1.1 to NACE Rev. 2 in business surveys

    Directory of Open Access Journals (Sweden)

    Jan van den Brakel

    2010-09-01

    Full Text Available This paper describes some of the methodological problems encountered with the change-over from the NACE Rev. 1.1 to the NACE Rev. 2 in business statistics. Different sampling and estimation strategies are proposed to produce reliable figures for the domains under both classifications simultaneously. Furthermore several methods are described that can be used to reconstruct time series for the domains under the NACE Rev. 2.

  19. Repository Surface Design Engineering Files Report Rev 00 ICN 1

    International Nuclear Information System (INIS)

    2001-01-01

    The objective of the Repository Surface Design Engineering Files Report Supplement [herein known as the Engineering Files (EF)] is to provide the surface design data needed by the Environmental Impact Statement (EIS) contractor to prepare the EIS and evaluate options and alternatives. This document is based on the Repository Surface Design Engineering Files Report, Revision 03 (CRWMS M and O 1999f) (EF Rev 03). Where facility and system designs have been changed for the Site Recommendation (SR) effort they are described in this report. EIS information provided in this report includes the following: (1) Description of program phases; there are no changes that impact this report. (2) A description of the major design requirements and assumptions that drive the surface facilities reference design is provided herein (Section 2.2), including the surface design resulting from recommendations regarding Enhanced Design Alternative (EDA) II, as discussed in the License Application Design Section Report (CRWMS M and O 1999d), and changes to the waste stream. See Section 2, Table 2-2, for the SR waste stream. (3) The major design requirements and assumptions that drive the surface facilities reference design are by reference to EF Rev 03; there are no changes that impact this report. (4) Description of the reference design concept and existing site conditions is by reference to EF Rev 03 (including Table 4-1, which is not included in this supplement); there are no changes that impact this report. (5) Description of alternative design cases is by reference to EF Rev 03; there are no changes that impact this report. (6) Description of optional inventory modules is by reference to EF Rev 03; there are no changes that impact this report. (7) Tabular summary level engineering values (i.e., staffing, wastes, emissions, resources, and land use) for the reference design and the alternative design cases that address construction, emplacement operations, caretaker operations, and

  20. Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas

    Science.gov (United States)

    New Hampshire Fleet Revs up With Natural Gas to someone by E-mail Share Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Facebook Tweet about Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Twitter Bookmark Alternative Fuels Data Center

  1. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs

    International Nuclear Information System (INIS)

    Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang; Liu, Chao; Zhang, Hui

    2015-01-01

    Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.

  2. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Liu, Chao, E-mail: liuchao9@mail.sysu.edu.cn [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Zhang, Hui [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China)

    2015-12-15

    Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.

  3. Systèmes coopératifs hybride Satellite-Terrestre : analyse de performance et dimensionnement du système

    OpenAIRE

    Sreng, Sokchenda

    2012-01-01

    Les systèmes de communications par satellite sont utilisés dans le contexte de la radiodiffusion, de la navigation, du sauvetage et du secours aux sinistrés, car ils permettent de fournir des services sur une large zone de couverture. Cependant, cette zone de couverture est limitée par l'effet de masquage provoqué par des obstacles qui bloquent la liaison directe entre le satellite et un utilisateur terrestre. L'effet de masquage devient plus sévère en cas de satellites à faibles angles d'élé...

  4. Wind Farm Wake: The Horns Rev Photo Case

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Rasmussen, Leif; Peña, Alfredo

    2013-01-01

    The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surf...... in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog....

  5. Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.

    Directory of Open Access Journals (Sweden)

    Thomas Vercruysse

    Full Text Available HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs. We have recently identified a llama single-domain antibody (Nb190 as the first inhibitor targeting the Rev multimerization function in cells. This nanobody is a potent intracellular antibody that efficiently inhibits HIV-1 viral production. In order to gain insight into the Nb190-Rev interaction interface, we performed mutational and docking studies to map the interface between the nanobody paratope and the Rev epitope. Alanine mutants of the hyper-variable domains of Nb190 and the Rev multimerization domains were evaluated in different assays measuring Nb190-Rev interaction or viral production. Seven residues within Nb190 and five Rev residues are demonstrated to be crucial for epitope recognition. These experimental data were used to perform docking experiments and map the Nb190-Rev structural interface. This Nb190-Rev interaction model can guide further studies of the Nb190 effect on HIV-1 Rev function and could serve as starting point for the rational development of smaller entities binding to the Nb190 epitope, aimed at interfering with protein-protein interactions of the Rev N-terminal domain.

  6. La gestión ecológico-cultural en el paisaje de montaña

    Directory of Open Access Journals (Sweden)

    Recoder, P. Montserrat

    1992-12-01

    propagan automáticamente. Conviene mantener la investigación ecológica tradicional, pero completándola con la enseñanza y experimentos realizados en valles de montaña que no quieren morir culturalmente. Podemos "humanizar paisajes", revitalizados en esos ambientes que sólo pueden progresar a partir de sus recursos ganaderos y artesanos, con ayuda del turismo desmasificado, integrado al sistema, al paisaje. Será muy útil plantear acciones concretas en nuestras montañas Peninsulares y conectar con el proyecto SBl ("Sustainable Biosphere Iniciative" de la Ecological Society of America, para investigar a fondo nuestros recursos naturales, bióticos y culturales, los del hombre con su cultura tradicional que debe seguir evolucionando correctamente, para salvar todas las limitaciones actuales.
    [fr] L'auteur fait un résumé de l'évolution de ses idées suite à la connaissance botanique des phytocénoses situées dans un milieu de montagne diversifié, —avec des cultures traditionnelles très spécialisées et en continuelle évolution jusqu'à nos jours— afin de dresser le schéma des deux types extrêmes de gestion: 1 Celle que l'on exerce de loin, "à distance", et 2 la gestion "internalisée" ou autogestionnaire, propre à chaque système, qui permet une progression en accord avec les tendances communautaires et facilite les processus d'adaptation, aussi bien pour le milieu géophysique que pour le milieu biotique et social de chaque vallée et l'organisation politique supérieure, jusqu'à la Communauté Européenne. Il est intéressant dans ce cadre de créer des "Modèles" à partir du reste des cultures qui persistent ou prospèrent dans des milieux déterminés; il est utile de connaître leurs mécanismes régulateurs "homéostatiques", qui justement sont ceux qui ont permis de maintenir leur "cohésion culturelle" et qui, même, la diffusent automatiquement^ Il convient de poursuivre les recherches écologiques traditionnelles, mais en les

  7. Initiatives canadiennes d'avant-garde en matière de systèmes de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Initiatives canadiennes d'avant-garde en matière de systèmes de santé équitables et d'amélioration de la santé des mères et des enfants ... renforcement des systèmes de santé : d'une part, le recrutement des travailleurs de la santé, le maintien de cet effectif et, d'autre part, le rôle des systèmes d'information sur la santé.

  8. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  9. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Document Server

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  10. 12MW Horns Rev experiment[Wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Hasager, C.B.; Pena, A; Mikkelsen, T.; Courtney, M.; Antoniou, I.; Gryning, S.-E.; Hansen, P. [Risoe National Lab., DTU, Wind Energy Dept. (Denmark); Soerensen, P.B. [DONG Energy (Denmark)

    2007-10-15

    The 12MW project with the full title '12 MW wind turbines: the scientific basis for their operation at 70 to 270 m height offshore' has the goal to experimentally investigate the wind and turbulence characteristics between 70 and 270 m above sea level and thereby establish the scientific basis relevant for the next generation of huge 12 MW wind turbines operating offshore. The report describes the experimental campaign at the Horns Rev offshore wind farm at which observations from Doppler Laser LIDAR and SODAR were collected from 3 May to 24 October 2006. The challenges for mounting and operating the instruments on the transformer platform at Horns Rev were overcome by a close collaboration between DONG energy and Risoe National Laboratory DTU. The site is presented. In particular, three tall offshore meteorological masts, up to 70 m tall, provided a useful source of meteorological data for comparison to the remotely sensed wind and turbulence observations. The comparison showed high correlation. The LIDAR and SODAR wind and turbulence observations were collected far beyond the height of the masts (up to 160 m above sea level) and the extended profiles were compared to the logarithmic wind profile. Further studies on this part of the work are on-going. Technical detail on LIDAR and SODAR are provided as well as theoretical work on turbulence and atmospheric boundary layer flow. Selected results from the experimental campaign are reported. (au)

  11. Wind Farm Wake: The 2016 Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Charlotte Bay Hasager

    2017-03-01

    Full Text Available Offshore wind farm wakes were observed and photographed in foggy conditions at Horns Rev 2 on 25 January 2016 at 12:45 UTC. These new images show highly contrasting conditions regarding the wind speed, turbulence intensity, atmospheric stability, weather conditions and wind farm wake development as compared to the Horns Rev 1 photographs from 12 February 2008. The paper examines the atmospheric conditions from satellite images, radiosondes, lidar and wind turbine data and compares the observations to results from atmospheric meso-scale modelling and large eddy simulation. Key findings are that a humid and warm air mass was advected from the southwest over cold sea and the dew-point temperature was such that cold-water advection fog formed in a shallow layer. The flow was stably stratified and the freestream wind speed was 13 m/s at hub height, which means that most turbines produced at or near rated power. The wind direction was southwesterly and long, narrow wakes persisted several rotor diameters downwind of the wind turbines. Eventually mixing of warm air from aloft dispersed the fog in the far wake region of the wind farm.

  12. rev piyasaları ve vergilendirilmesi

    OpenAIRE

    İşler, İsmail; Utku, Mehmet

    2015-01-01

    rev piyasaları kavramı, vadeli işlem sözleşmeleri (forward, futures), opsiyon sözleşmeleri, swap sözleşmeleri ve aracı kuruluş varantları işlemlerinin tamamını içermektedir. Bu tür işlemler vadeli işlemlerdir. Vadeli işlemlerin ortak özelliği, ilerideki bir tarihte teslimatı yapılmak üzere herhangi bir malın veya finansal aracın, bugünden alım satımının yapılmasıdır. Bu çalışmada türev araçların tanımları ve vergilendirilmeleri örneklerle açıklanacaktır. The term derivatives market invol...

  13. Plan de empresa para una granja de gallinas ecológicas

    OpenAIRE

    Martínez Cañada, Alberto

    2014-01-01

    Este TFG surge como respuesta a los principales problemas del medio rural: despoblación, envejecimiento poblacional y estancamiento de la economía rural. Así se propone una actividad respetuosa con el medio ambiente, generadora de empleo y revitalizante para el municipio donde se instalará la explotación: la avicultura ecológica de puesta.El estudio se estructura en 4 capítulos; el 1º se centra en el estudio del medio rural, el 2ºes un análisis tecnológico de la explotación, el 3º un análisis...

  14. Análise de risco ecológico na Lagoa da Vela

    OpenAIRE

    Abrantes, Nelson José Cabaços

    2007-01-01

    A Análise de Risco Ecológico (ARE) é um processo sistemático de avaliação da probabilidade de efeitos adversos ocorrerem em resultado da exposição a um ou mais agentes de stress ambiental. No contexto da tomada de decisão relativa aos problemas ambientais, a ARE tem-se mostrado como uma ferramenta fundamental e eficaz, sendo cada vez mais utilizada nos países desenvolvidos. Contudo, em Portugal, o seu uso continua muito limitado e incipiente. A Lagoa da Vela, localizada n...

  15. Comprender la realidad sin representaciones: Affordances y psicología ecológica

    Directory of Open Access Journals (Sweden)

    Manuel Heras Escribano

    2012-08-01

    Full Text Available Frente al paradigma tradicional en ciencia cognitiva, donde la metáfora del ordenador es la imperante, la psicología ecológica se ofrece como la alternativa más potente en el futuro desarrollo de las investigaciones sobre el fenómeno de la cognición. Dentro de ella, la noción de affordance juega un papel fundamental, aunque el concepto no está exento de polémica.

  16. Anfibios de un bosque seco tropical: Reserva Ecológica Arenillas, Ecuador

    OpenAIRE

    Szekely, József Paul

    2016-01-01

    Arenillas Ecological Reserve (Reserva Ecológica Arenillas - REA) is located in southwestern Ecuador, close to the Peruvian border, and belongs to the Tumbesian Endemism Region and is one of the last remnants of tropical dry forests at altitudes below 100 m a.s.l. Climate is characterized by a rainy season extending from January to May and a dry season extending from June to December. Few studies on the amphibians from the reserve have been made so far. Over a period of twelve months, from 201...

  17. Estufas ecológicas ahorradoras de leña

    OpenAIRE

    Franco, Abelardo

    2012-01-01

    Unos de los proyectos emblemáticos que desarrolla la Sede Regional de Bocas del Toro, es el de la “Estufa Ecológica Ahorrativa de Leña”. Basada en el modelo Eco-Justa construido en Honduras, es la única estufa de este prototipo construida con ladrillos de arcilla y chimenea en la región. Este Proyecto lo desarrolla la Sede Regional de Bocas del Toro, a través del Ing. Abelardo Franco, docente en el área Ambiental, conjuntamente con la Cooperativa Bananera del Atlántico (COOBANA, R.L.) y el av...

  18. La cubierta ecológica como material de construcción

    Directory of Open Access Journals (Sweden)

    Neila, Javier

    2000-06-01

    Full Text Available The ecological roof is one with a cover of vegetation with a thin substratum and a layer of low level plants. This type of roof has many advantages including architectural, construction, environmental and aesthetic ad vantages. In order to determine the thermal behaviour of models with ecological roofs, simulations were performed on these and other types of construction in the two areas involved in the study: Maracaibo and Madrid. Five different roofs were created for the study, analysed in four ways: 1 with the building windows closed throughout the whole 24 hours, 2 with the windows closed during the day and open at night; 3 open 24 hours; 4 open during the day and closed at night. The simulation tool used in the study was the "Method of Interior Temperature Evolution Calculation" developed by Javier Neila. The results obtained show that the ecological roof reduces the heat transference in hot seasons, acting as exterior insulation, and preventing heat loss by radiation into space in winter.La cubierta ecológica es un tipo de cubierta vegetal con un substrato de poco espesor y una capa vegetal con plantas de bajo porte. Las ventajas de este tipo de cubierta, abarcan aspectos arquitectónicos, constructivos, medioambientales y estéticos. Para realizar estudios a través de modelos de ordenador con cubiertas ecológicas, primero se determinó el valor de conductividad térmica equivalente del substrato y capa vegetal, utilizando las ecuaciones de balance térmico, lo cual fue comprobado con un ensayo de laboratorio y, con estos resultados, se realizaron simulaciones térmicas en los espacios con cubiertas ecológicas comparándolos con sistemas constructivos de cubiertas utilizados en las dos zonas de estudio: Maracaibo y Madrid. Para el estudio se establecieron cinco alternativas de cubiertas, analizándose de cuatro maneras diferentes: 1 cerrada durante las 24 horas. 2 cerrada durante el día y abierta en la noche ; 3 abierta las 24 horas

  19. Aspectos biológicos y ecológicos de las garrapatas duras

    OpenAIRE

    Polanco-Echeverry, Diana Nayibe; Ríos-Osorio, Leonardo Alberto

    2016-01-01

    Las garrapatas duras son ectoparásitos hematófagos de la familia Ixodidae. Estos ácaros han sido considerados siempre como agentes disruptores de los sistemas ganaderos, en los que se les reconoce como causantes de pérdidas económicas y productivas. Sin embargo, su función ecológica es importante para el equilibrio dinámico del sistema de producción de carne o leche bovina. El conocimiento de su biología y ecología puede ilustrar la toma de decisiones sanitarias que se hagan sobre estos organ...

  20. Indicador espacial del metabolismo urbano. Huella Ecológica de la ciudad de Tandil, Argentina

    OpenAIRE

    Guerrero, Elsa Marcela; Guiñirgo, Fernando

    2008-01-01

    Además de problemas urbanos evidentes -contaminación, residuos, etc.-, existe un problema asociado a la propia dinámica del sistema urbano que es de interés: la apropiación creciente de ecosistemas productivos externos destinados a satisfacer los requerimientos del metabolismo urbano de la ciudad de Tandil, Argentina. Se emplea para su cálculo, la Huella Ecológica (HE) (Rees 1996a; Wackernagel 1996) que permite evaluar en términos espaciales –hectáreas- los requerimientos de alimentos, combus...

  1. Humedal urbano en Punta Arenas: Sustentabilidad del Proyecto Parque Ecológico Humedal Tres Puentes

    OpenAIRE

    Luis Inostroza Pino

    2009-01-01

    El Humedal Tres Puentes, ubicado en la entrada norte de Punta Arenas, es un espacio relevante desde el punto de vista ecológico y hábitat de una numerosa avifauna, uno de los más importantes de la ciudad. Sin embargo el Humedal está seriamente amenazado, dado su ubicación sobre uno de los principales vectores de crecimiento de la ciudad de Punta Arenas, en terrenos que han adquirido plusvalía paulatinamente, bien por efecto de la obra pública del Estado o por el simple crecimiento vegetativo ...

  2. Systèmes multi-échelles, Modélisation et simulation

    Science.gov (United States)

    Le Bris, Claude

    Systèmes multi-échelles est une introduction à la problématique des systèmes multi-échelles du point de vue du mathématicien appliqué. Il se compose d'une mosaique d'exemples dont le seul lien est d'appartenir à la très grande famille des problèmes issus de la physique au sens large qui présentent pour leur modélisation et leur simulation cette difficulté essentielle de comporter en leur sein des échelles de temps oud'espace très différentes.

  3. A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis

    Directory of Open Access Journals (Sweden)

    Jean-Guillaume Emond-Rheault

    2017-06-01

    Full Text Available The Salmonella Syst-OMICS consortium is sequencing 4,500 Salmonella genomes and building an analysis pipeline for the study of Salmonella genome evolution, antibiotic resistance and virulence genes. Metadata, including phenotypic as well as genomic data, for isolates of the collection are provided through the Salmonella Foodborne Syst-OMICS database (SalFoS, at https://salfos.ibis.ulaval.ca/. Here, we present our strategy and the analysis of the first 3,377 genomes. Our data will be used to draw potential links between strains found in fresh produce, humans, animals and the environment. The ultimate goals are to understand how Salmonella evolves over time, improve the accuracy of diagnostic methods, develop control methods in the field, and identify prognostic markers for evidence-based decisions in epidemiology and surveillance.

  4. Analyse des systèmes d'innovation (Burkina Faso) | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce projet a pour objectif d'améliorer l'efficience du système d'innovation en construction au Burkina Faso en renforçant les échanges entre chercheurs, inventeurs, ... Faso : communication présentée à la IIIe Conférence Internationale de KMA « Knowledge Management Africa » sous le thème « le... 49285. Journal articles.

  5. Architecture, des normes et des systèmes d'information libres, phase ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Architecture, des normes et des systèmes d'information libres, phase II (OASIS II) - Renforcement des capacités dans l'ensemble de l'Afrique. Sur presque tout le continent africain, la prestation des services de santé est limitée en raison des maigres ressources disponibles et de la charge de morbidité de plus en plus ...

  6. Armer les villes contre la faim : Systèmes alimentaires urbains ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le XXe siècle a été le témoin d'une croissance massive des populations urbaines. ... On y explore le rôle que les structures existantes de marketing et de distribution peuvent jouer pour améliorer l'accessibilité, les systèmes de distribution alimentaire en émergence et leur apport éventuel à l'élimination de la faim dans les ...

  7. Consolidation des systèmes d'approvisionnement en Amérique ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les technologies de l'information et de la communication (TIC) jouent un rôle clé dans la modernisation des systèmes d'administration publique, en général, ... Reporte final : VII Conferencia Anual sobre Compras Gubernamentales de las Américas, 18 al 20 de Octubre de 2011, Santo Domingo, República Dominicana.

  8. Systèmes d'information sur la santé

    International Development Research Centre (IDRC) Digital Library (Canada)

    personnel spécialisé — et bien souvent le leadership et la vision — pour ... Recourir aux données probantes pour réduire la mortalité maternelle au Nigeria. □ Incorporer les TIC aux systèmes de santé. □ Intégrer les collectivités à la surveillance du .... il y a lieu de mieux comprendre comment ces outils peuvent étayer la ...

  9. Influence du système de logement sur quelques performances ...

    African Journals Online (AJOL)

    Les effets de deux systèmes de logement (batterie de cages et sol sur litière) sur les performances zootechniques et économiques des poules pondeuses ont été évalués en zone tropicale humide, au sud du Benin. Un total de 180 poules pondeuses (Isa Brown) de 26 semaines d'âge était réparti en deux groupes de 108 et ...

  10. Mikrojádra operačních systémů

    OpenAIRE

    Beneš, Eduard

    2007-01-01

    Táto práca sa zaoberá problematikou mikrojadier operačných systémov. Prvá časť je zameraná na oboznámenie s problematikou jadier operačných systémov. Obsahuje základné vlastnosti a mechanizmy druhej generácie mikrojadier reprezentovanej mikrojadrom L4, na ktoré sa zameriavame v ďalších častiach práce. Následne sú opísané dva rôzne porty operačného systému Linux nad mikrojadro L4, sú to L4Linux a Wombat. V druhej časti práce je popísaný spôsob inštalácie vybraných portov a hlavné problémy, kto...

  11. Implementace protokolu ACP do operačního systému L4

    OpenAIRE

    Kolarík, Tomáš

    2012-01-01

    Práce se zabývá implementací protokolu ACP, který slouží k řízení přístupu pro operační systém založený na mikrojádře L4. Teoretická část práce se zabývá možnostmi řízení přístupu v počítačových sítích. Pozornost je se přitom soustřeďuje na AAA systémy, které řízení přístupu umožňují. Následně je podrobně popsán protokol ACP, typy jeho zpráv a reakce na ně. Druhá část teoretické přípravy je věnována operačním systémům kde se podrobněji zabývá jejich architekturou a službami. Následně je blíže...

  12. Optimalizace systému zaměstnaneckých benefitů v podniku

    OpenAIRE

    Knyblová, Lucie

    2009-01-01

    Cílem diplomové práce „Optimalizace systému zaměstnaneckých benefitů v podniku“ je analyzovat zaměstnanecké benefity dle současné právní úpravy z pohledu daňového zatížení podniku i zaměstnance. Dílčím cílem je na základě dotazníkového šetření zjistit spokojenost zaměstnanců se současným systémem zaměstnaneckých benefitů v konkrétním podniku a navrhnout určité změny, které povedou ke spokojenosti zaměstnanců a optimalizaci systému z daňového hlediska jak pro zaměstnance tak pro zaměstnavatele...

  13. Un système d'avant-garde rend l'accès à l'information abordable ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    27 oct. 2010 ... Bien avant l'avènement des ordinateurs personnels et d'Internet, les énormes collections et bases de données des organismes des Nations Unies étaient consultables sous forme numérique par le truchement d'un système appelé ISIS. Par contre, ce système ne pouvant fonctionner qu'au moyen ...

  14. Efectos distributivos de los tributos ecológicos. Apuntes metodológicos

    Directory of Open Access Journals (Sweden)

    Tomás J. López-Guzmán Guzmán

    2005-01-01

    Full Text Available El objetivo de este trabajo es presentar una propuesta metodológica para realizar un correcto diseño de un tributo ecológico que evite que determinados grupos sean los más perjudicados con la introducción de una ecotasa. Las pautas metodológicas se centran en el análisis de la estructura básica de un tributo ambiental, la determinación de los grupos de referencia y el análisis de los efectos distributivos. El principal resultado es que la introducción de los tributos ambientales debe tener en cuenta el probable impacto negativo en determinados grupos, sobre todo cuando se grave la energía eléctrica. Por tanto, sería necesario que previo a la introducción de los tributos ecológicos se elaborasen estudios necesarios para evitar su impacto negativo o, en su caso, se abordasen en la misma regulación políticas de compensación y mitigación.

  15. Efectos ecológicos del fenómeno ENOS en Colombia

    Directory of Open Access Journals (Sweden)

    Yesid Carvajal

    2014-06-01

    Full Text Available El fenómeno ENOS, tiene un sustancial efecto sobre las variaciones del clima a nivel mundial; por lo tanto, no sorprende que sus efectos tengan un impacto ecológico y socioeconómico fuerte, alterando la seguridad alimentaria de los países a nivel mundial. Ante este panorama, es comprensible que haya despertado el mayor interés mundial, no sólo en los especialistas en meteorología y oceanografía sino también entre biólogos, ecólogos, físicos, matemáticos, agrónomos, hidrólogos, economistas, sociólogos y planificadores, entre otros. En el presente documento, se muestra algunos de los principales efectos ecológicos en Colombia durante las fases extremas cálida (El Niño y fría (La Niña, indicando que es una necesidad urgente, orientar la investigación en sus causas, consecuencias e impactos.

  16. Proyecto de una planta industrial de ladrillos ecológicos del tipo suelo-cemento en Arequipa

    OpenAIRE

    Murillo Salas, Erick Manuel; Murillo Salas, Erick Manuel

    2015-01-01

    En este trabajo se desarrolló el proyecto de una planta de ladrillos ecológicos en la ciudad de Arequipa. Se fabricó un tipo de ladrillo compuesto de arena-arcilla y reforzado con cemento y se le sometió a tres (3) ensayos de laboratorio para comprobar su resistencia y durabilidad. Actualmente en el Perú no existe ninguna planta para la producción de un ladrillo ecológico por medios industriales. En la ciudad de Arequipa, la gran mayoría de las ladrilleras son artesanales e informales, alg...

  17. Applications of the INFCIRC225/rev5 to the national physical protection regime

    International Nuclear Information System (INIS)

    Kim, Jae Gwang

    2011-01-01

    The IAEA's first effort for playing a key role in physical protection of nuclear material and facilities resulted in the publication of 'Recommendations for the physical protection of nuclear material' in 1972. These recommendations were revised by a group of experts in co-operation with the IAEA Secretariat and the revised version was published in 1975 in INFCIRC/225. The document was subsequently revised in 1977(rev.1), 1989(rev.2), in 1993(rev.3) and 1998(rev4). The Physical Protection regime in ROK has been established on the basis of INFCIRC225 rev4 since 2004 IAEA recently published The INFCIRC 225 rev5 through the 2 years expert consultations. The publication recommended 12 nuclear security fundamentals and requirements of physical protection of nuclear material and nuclear facility to the member states. This paper suggests the several applications to the national physical protection system from the 12 fundamentals and the requirements

  18. Amazônia socioambiental: sustentabilidade ecológica e diversidade social

    Directory of Open Access Journals (Sweden)

    Deborah Lima

    2005-08-01

    Full Text Available ESTE ARTIGO baseia-se no emprego de um conceito central do discurso ambientalista - o de sustentabilidade ecológica - para construir um quadro analítico da diversidade socioambiental da Amazônia contemporânea. O exercício consiste em um ordenamento geral de categorias sociais segundo seu comportamento ambiental. Este é o ponto de partida para uma análise dos fundamentos históricos, econômicos e culturais da sustentabilidade ecológica atribuída a cada segmento social. A análise mostra a complexidade da interação entre múltiplos fatores que explicam o comportamento ecológico particular de cada um dos seguintes segmentos sociais considerados: a povos indígenas de comércio esporádico, b povos indígenas de comércio recorrente, c povos indígenas dependentes da produção mercantil, d pequenos produtores "tradicionais", e latifúndios "tradicionais", f latifúndios recentes, g migrantes/ fronteira, h grandes projetos e i exploradores itinerantes. Com este exercício, alguns estereótipos consagrados são contrariados, como aqueles que relacionam baixa sustentabilidade ecológica com pobreza, ou alta sustentabilidade ecológica com identidade indígena. Concluímos mostrando a importância de prosseguir com análises de amplo espectro para entender a diversidade socioambiental da Amazônia.WITH ONE of the central concepts of environmental discourse - that of ecological sustainability - we analyse the social diversity of contemporary Amazonia, presenting classification of Amazonian social segments according to the degree of environmental sustainability of their productive activities. With no intention of covering all of Amazonian social diversity, we identify nine of its main segments: Indians of sporadic commerce, Indians of recurrent commerce, Indians dependent on mercantile production, traditional peasants, traditional ranchers, recently established ranchers, frontier migrants, large scale entrepreneurial projects, and itinerant

  19. Influência do preço e as stratégias de comunicação visual baseadas em simbologia cultural sobre a preferência de marcas ecológicas e consumo sustentável

    Directory of Open Access Journals (Sweden)

    Haidy Johana Moreno C.

    2014-03-01

    Full Text Available Rev.esc.adm.neg Esta investigación pretende establecer la influencia del precio y las estrategias de comunicación visual, basadas en simbología cultural sobre la preferencia de marcas ecológicas en la categoría de productos de aseo en la ciudad de Bogotá, buscando fomentar el consumo sostenible en los hogares. Para ello, se realizaron dos fases: un estudio de tipo descriptivo para establecer la estrategia de precio más persuasiva para el consumidor en un producto ecológico en la categoría de aseo. Posteriormente en la fase dos, se realizó un estudio experimental mediante un diseño factorial 2x2x2, donde la primera variable independiente fue comunicación visual, la segunda, el enmarcamiento ecológico y la tercera, el precio; variable que actuó como elemento de influencia utilizada en cada grupo experimental. Los participantes fueron expuestos a estímulos visuales de tipo bidimensional y tridimensional, relacionados con las estrategias de precio; los resultados muestran, que de la manera como se comunica el precio, se present una alta incidencia en la preferencia de compra, debido a que los consumidores son más perceptibles a los descuentos y a las ofertas. Otro de los hallazgos relevantes fue la estrategia de posicionamiento en marcas verdes, las cuales deben generar en los consumidores una garantía que realmente es un producto que aporta al cuidado medioambiental y para ello, se requiere de información precisa y detallada en el diseño, los empaques, los envases, la marca y demás atributos del producto; pues en definitiva, en términos publicitarios que la comunicación visual en consumo sustentable cumple una función también informativa.

  20. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee at its meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  1. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  2. Intégration des pluies prévues du système AROME-PI dans le système AIGA

    OpenAIRE

    Demargne, J.; Javelle, P.

    2015-01-01

    / Cette étude a été réalisée pour le SCHAPI (Service Central d'Hydrométéorologie et d'Appui à la Prévision des Inondations) pour analyser l'amélioration du système d'avertissement sur la possibilité de crues rapides AIGA en intégrant des prévisions de pluie future à courte échéance et fine résolution spatio-temporelle et en prenant en compte leurs incertitudes. Le SCHAPI développe actuellement un service d'avertissement automatisé valable sur l'ensemble de la France, qui sera complété par un ...

  3. Intégration des pluies prévues du système COSMO-DE-EPS dans le système AIGA

    OpenAIRE

    Demargne, J.; Javelle, P.

    2014-01-01

    / Cette étude a été réalisée pour le SCHAPI (Service Central d'Hydrométéorologie et d'Appui à la Prévision des Inondations) pour analyser l'amélioration du système d'avertissement aux crues rapides AIGA en prenant en compte les incertitudes des pluies futures et des paramètres du modèle hydrologique calibré et régionalisé. Le SCHAPI développe actuellement un service d'avertissement automatisé valable sur l'ensemble de la France, qui sera complété par un service expertisé d'avertissement sur d...

  4. REV7, a new gene concerned with UV mutagenesis in yeast

    International Nuclear Information System (INIS)

    Lawrence, C.W.; Das, G.; Christensen, R.B.

    1985-01-01

    Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. Rev7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX. (orig.)

  5. REV7, a new gene concerned with UV mutagenesis in yeast

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, C.W.; Das, G.; Christensen, R.B.

    1985-06-26

    Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. REV7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX.

  6. Epistatic participation of REV1 and REV3 in the formation of UV-induced frameshift mutations in cell cycle-arrested yeast cells

    Energy Technology Data Exchange (ETDEWEB)

    Heidenreich, Erich [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)]. E-mail: erich.heidenreich@meduniwien.ac.at; Eisler, Herfried [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria); Steinboeck, Ferdinand [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)

    2006-01-29

    Mutations arising in times of cell cycle arrest may provide a selective advantage for unicellular organisms adapting to environmental changes. For multicellular organisms, however, they may pose a serious threat, in that such mutations in somatic cells contribute to carcinogenesis and ageing. The budding yeast Saccharomyces cerevisiae presents a convenient model system for studying the incidence and the mechanisms of stationary-phase mutation in a eukaryotic organism. Having studied the emergence of frameshift mutants after several days of starvation-induced cell cycle arrest, we previously reported that all (potentially error-prone) translesion synthesis (TLS) enzymes identified in S. cerevisiae did not contribute to the basal level of spontaneous stationary-phase mutations. However, we observed that an increased frequency of stationary-phase frameshift mutations, brought about by a defective nucleotide excision repair (NER) pathway or by UV irradiation, was dependent on Rev3p, the catalytic subunit of the TLS polymerase zeta (Pol {zeta}). Employing the same two conditions, we now examined the effect of deletions of the genes coding for polymerase eta (Pol {eta}) (RAD30) and Rev1p (REV1). In a NER-deficient strain background, the increased incidence of stationary-phase mutations was only moderately influenced by a lack of Pol {eta} but completely reduced to wild type level by a knockout of the REV1 gene. UV-induced stationary-phase mutations were abundant in wild type and rad30{delta} strains, but substantially reduced in a rev1{delta} as well as a rev3{delta} strain. The similarity of the rev1{delta} and the rev3{delta} phenotype and an epistatic relationship evident from experiments with a double-deficient strain suggests a participation of Rev1p and Rev3p in the same mutagenic pathway. Based on these results, we propose that the response of cell cycle-arrested cells to an excess of exo- or endogenously induced DNA damage includes a novel replication

  7. SSC-K code users manual (rev.1)

    International Nuclear Information System (INIS)

    Kwon, Y. M.; Lee, Y. B.; Chang, W. P.; Hahn, D.

    2002-01-01

    The Supper System Code of KAERI (SSC-K) is a best-estimate system code for analyzing a variety of off-normal or accidents in the heat transport system of a pool type LMR design. It is being developed at Korea Atomic Energy Research Institution (KAERI) on the basis of SSC-L, originally developed at BNL to analyze loop-type LMR transients. SSC-K can handle both designs of loop and pool type LMRs. SSC-K contains detailed mechanistic models of transient thermal, hydraulic, neutronic, and mechanical phenomena to describe the response of the reactor core, coolant, fuel elements, and structures to accident conditions. This report provides a revised User's Manual (rev.1) of the SSC-K computer code, focusing on phenomenological model descriptions for new thermal, hydraulic, neutronic, and mechanical modules. A comprehensive description of the models for pool-type reactor is given in Chapters 2 and 3; the steady-state plant characterization, prior to the initiation of transient is described in Chapter 2 and their transient counterparts are discussed in Chapter 3. Discussions on the intermediate heat exchanger (IHX) and the electromagnetic (EM) pump are described in Chapter 4 and 5, respectively. A model of passive safety decay heat removal system (PSDRS) is discussed in Chapter 6, and models for various reactivity feedback effects are discussed in Chapter 7. In Chapter 8, constitutive laws and correlations required to execute the SSC-K are described. New models developed for SSC-K rev.1 are two dimensional hot pool model in Chapter 9, and long term cooling model in Chapter 10. Finally, a brief description of MINET code adopted to simulate BOP is presented in Chapter 11. Based on test runs for typical LMFBR accident analyses, it was found that the present version of SSC-K would be used for the safety analysis of KALIMER. However, the further validation of SSC-K is required for real applications. It is noted that the user's manual of SSC-K will be revised later with the

  8. De perceptos a frames: cognição ecológica e linguagem

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Duque

    2017-06-01

    Full Text Available Neste artigo, proponho uma abordagem ecológica de cognição e linguagem, demonstrando que os processos de conceptualização parecem emergir da interação organismo-ambiente. Tal abordagem cognitiva exige a coordenação dos dois extremos dessa emergência e a consideração de que o uso da linguagem inevitavelmente envolve tanto os processos iniciais de interação do organismo com o ambiente quanto as estruturas e os processos que emergem dessas interações. De acordo com a abordagem aqui proposta, desenvolvemos conceitos e reorientamos nossos pensamentos sobre o mundo por meio de um mecanismo conhecido como framing, isto é, o recurso discursivo-cognitivo de que dispomos para (remodelar circuitos neurais (ou frames.

  9. International entrepreneurship and effectuation: the Yaguara Ecológico Coffee case

    Directory of Open Access Journals (Sweden)

    Paula Porto

    2015-12-01

    Full Text Available The purpose of this study is to investigate the role of the entrepreneur and the characteristics of the internationalization process for Yaguara Ecológico, a small Brazilian coffee producer, in the light of different theoretical approaches. A literature review was done with special attention given to the theories of International Entrepreneurship and Effectuation. This paper deals with the International New Venture phenomenon (OVIATT; McDOUGALL, 1994, and in order to understand the importance of entrepreneurs in a company's internationalization process, the Effectuation theory was chosen that offers alternatives to describe how they think and behave when starting a new venture (PERRY et.al., 2012. The research method used a single case study and in-depth interviews were conducted with company managers. The results suggest that the theories offer explanations for the company's internationalization activities; however, some characteristics of this trend did not adhere to the theoretical propositions.

  10. Sustentabilidade Ecológica do Espeleoturismo na Serra da Bodoquena, Mato Grosso do Sul

    Directory of Open Access Journals (Sweden)

    Heros Santos Lobo

    2010-07-01

    Full Text Available Resumo O presente artigo apresenta uma análise da estrutura e produção do espeleoturismo na Serra da Bodoquena, sob o enfoque do ideário de ecoturismo e da sustentabilidade ecológica. A metodologia de pesquisa incluiu levantamentos documentais e de campo em cavidades naturais turísticas. As discussões apresentam aspectos técnico-metodológicos como caminhos viáveis para um espeleoturismo com princípios ecológicos e conservacionistas. Conclui-se que o espeleoturismo pode se firmar não somente como um segmento, mas também como uma nova forma de se fazer o turismo na Serra da Bodoquena. Para tanto, deve identificar novas possibilidades de procedimentos de gestão e manejo ambiental que possam ir além dos paradigmas e modelos vigentes. Palavras-chave: ecoturismo; espeleoturismo; gestão ambiental; Bonito-MS. Abstract This article presents the results of an analysis of the structure and production of speleotourism at Serra da Bodoquena, based on the precepts of ecotourism and ecological sustainability. The methodology included a survey of documents and fieldwork in natural cavities exploited for tourism. The discussion presents a technical-methodological approach for a speleotourism based on ecology and conservation. The study concludes that speleotourism can be established, not only as a specific market segment, but also as a new kind of tourism in the Serra da Bodoquena. Hence new opportunities for environmental management and control of impacts that may exist beyond the paradigms and current models should be identified. Keywords: ecotourism; speleotourism; environmental management; Bonito-MS. Resumen El presente artículo muestra un análisis de la estructura y producción del espeleoturismo en la Serra da Bodoquena, desde el enfoque de la ideología de ecoturismo y de la sostenibilidad ecológica. La metodología de investigación incluyó investigación documental y de campo en cuevas naturales turísticas. Las

  11. La Estructura de la Revolución Ecológica en Arquitectura

    OpenAIRE

    Chinchilla Moreno, Izaskun

    2017-01-01

    El objetivo que ha guiado, genuinamente, la investigación y la redacción de esta tesis, ha sido ser útil a arquitectos y diseñadores que, por convicción propia o por mediación de terceros, quieren poder idear e implementar arquitectura o productos más ecológicos. La tesis propondrá, a esos profesionales, una hipótesis de fondo: la aplicación profunda de los principios de la ecología a la arquitectura lo cambiaría todo; no se trata de un cambio parcial, se trata de una revolución. En virtud de...

  12. Criando contextos ecológicos de desenvolvimento e direitos humanos para adolescentes

    Directory of Open Access Journals (Sweden)

    Ana Paula Lazzaretti de Souza

    2011-08-01

    Full Text Available Neste estudo descreve-se a aplicação do método de Inserção Ecológica em um programa de intervenção para educação em direitos humanos e protagonismo juvenil para adolescentes em situação de vulnerabilidade social. A criação de um microssistema constituído pelos participantes e pela equipe executora do programa resulta em mudanças positivas de comportamento e respeito às regras, entre outros. Estas transformações surgem em consonância com a proposta da Abordagem Bioecológica do Desenvolvimento Humano, sobre a influência do ambiente. Este estudo reforça a importância da aplicação dos resultados em políticas públicas e sociais.

  13. Redakční systém sportovního klubu

    OpenAIRE

    Gvizd, Peter

    2015-01-01

    GVIZD, P., Redakční systém sportovního klubu. Brno, 2015. The aim of this Bachelor thesis is to create a content management systems's de-sign for the sport club Jednota Sokol Chocholná -- Velčice. The design is created on the basis of the club analysis and the identification of the key properties, which should be met by the content management system. Other properties of the content management system are deduced from the club requirements. The implementation was realized by standard technologi...

  14. Système de recommandation des services web sémantiques.

    OpenAIRE

    KARAOUZENE, Meryem

    2015-01-01

    : Les systèmes de recommandation sont capables d’estimer l’intérêt d’un utilisateur pour une ressource donnée à partir de certaines informations relatives à d’autres utilisateurs similaires et aux propriétés des ressources. Dans ce mémoire nous avons présenté les phases d’une application sur ce domaine en introduisant la notion de recommandation sociale basant sur le filtrage collaboratif pour structurer les services web sémantique, on Calculant des similarités entre items pour...

  15. Diagnostic des systèmes de culture à base de mil [ Pennisetum ...

    African Journals Online (AJOL)

    Objectif : Le présent travail a pour objectif, de faire un état des lieux des systèmes de production à base de mil en Côte d'Ivoire septentrionale afin de proposer de nouvelles pistes d'amélioration. Méthodologie et résultats : L'approche méthodologique s'est reposée sur une enquête auprès des paysans sur le terrain dans ...

  16. Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.

    Science.gov (United States)

    Han, Chang Woo; Jeong, Mi Suk; Jang, Se Bok

    2017-09-16

    Ras proteins are small GTPases that serve as master moderators of a large number of signaling pathways involved in various cellular processes. Activating mutations in Ras are found in about one-third of cancers. H-REV107, a K-Ras binding protein, plays an important role in determining K-Ras function. H-REV107 is a member of the HREV107 family of class II tumor suppressor genes and a growth inhibitory Ras target gene that suppresses cellular growth, differentiation, and apoptosis. Expression of H-REV107 was strongly reduced in about 50% of human carcinoma cell lines. However, the specific molecular mechanism by which H-REV107 inhibits Ras is still unknown. In the present study, we suggest that H-REV107 forms a strong complex with activating oncogenic mutation Q61H K-Ras from various biochemical binding assays and modeled structures. In addition, the interaction sites between K-Ras and H-REV107 were predicted based on homology modeling. Here, we found that some structure-based mutants of the K-Ras disrupted the complex formation with H-REV107. Finally, a novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. RevManHAL: towards automatic text generation in systematic reviews.

    Science.gov (United States)

    Torres Torres, Mercedes; Adams, Clive E

    2017-02-09

    Systematic reviews are a key part of healthcare evaluation. They involve important painstaking but repetitive work. A major producer of systematic reviews, the Cochrane Collaboration, employs Review Manager (RevMan) programme-a software which assists reviewers and produces XML-structured files. This paper describes an add-on programme (RevManHAL) which helps auto-generate the abstract, results and discussion sections of RevMan-generated reviews in multiple languages. The paper also describes future developments for RevManHAL. RevManHAL was created in Java using NetBeans by a programmer working full time for 2 months. The resulting open-source programme uses editable phrase banks to envelop text/numbers from within the prepared RevMan file in formatted readable text of a chosen language. In this way, considerable parts of the review's 'abstract', 'results' and 'discussion' sections are created and a phrase added to 'acknowledgements'. RevManHAL's output needs to be checked by reviewers, but already, from our experience within the Cochrane Schizophrenia Group (200 maintained reviews, 900 reviewers), RevManHAL has saved much time which is better employed thinking about the meaning of the data rather than restating them. Many more functions will become possible as review writing becomes increasingly automated.

  18. Tiempo y sucesión ecológica en Ramón Margalef

    Directory of Open Access Journals (Sweden)

    Vargas Abarzúa, Esteban

    2010-02-01

    Full Text Available In this paper we attempt to think about the time in the Margalef’s ecological succession theory. In the classical model of ecological succession, populations succeed each other. Each phases of that succession “as a temporary phase” is merely juxtaposed with the other. It is the clock time, time like “measure” of the clock. Time here is absolute, independent of the process like in Newton. This does not happen in the model of Margalef. He thinks the ecosystem like a process in which energy is transfer and information acumulated. Thus, in the dynamic process of ecosystem appears various phases determined by the intrinsic dynamics of the system. Each ecosystem has its own time.

    En este trabajo intentamos meditar la concepción de tiempo en la teoría de sucesión ecológica de Margalef. En un modelo clásico de sucesión ecológica, las poblaciones se suceden unas a otras. Cada fase de esa sucesión “en tanto fase temporal” está meramente yuxtapuesta a las demás fases. Es el tiempo cronométrico, el tiempo como “medida” del reloj. El tiempo es aquí algo absoluto, independiente del proceso como en Newton. Esto no ocurre en el modelo de Margalef. Él piensa el ecosistema como un proceso de transferencia de energía y acumulación de información. Por esto, en el proceso dinámico del ecosistema existen diversas fases determinadas por la dinámica intrínseca del sistema. Cada ecosistema posee así su tiempo propio.

  19. TIPNIS y Amazonia: Contradicciones en la agenda ecológica de Bolivia

    Directory of Open Access Journals (Sweden)

    Ricardo Calla Ortega

    2012-04-01

    Full Text Available Abstract:The ecological agenda of the government of Evo Morales shows great contradictions. In international meetings it presents itself as the radical defender of the environmental rights of the Latin American peoples. In its own country, it pursues developmentalist policies which are based on the extraction of natural resources. This policy is causing large conflicts within the country. The most striking has been over the construction of a highway through the national park of TIPNIS. The contradiction between its in-ternational position and internal policies, which are far less green, is causing severe damage to the credibility of the Morales government, within and outside the country.Resumen:La agenda ecológica del gobierno de Evo Morales demuestra grandes contradicciones. En los encuentros internacionales se presen-ta como un defensor radical de los derechos ecológicos de los pueblos latinoamericanos. En su propio país está persiguiendo un pro-yecto desarrollista basado en la extracción de recursos nacionales. Esta política está causando grandes conflictos dentro del país. La más llamativa ha sido sobre la construc-ción de una autopista por el parque nacional del TIPNIS. La contradicción entre su pos-tura internacional y una política mucho me-nos verde al interior está dañando aguda-mente la credibilidad del gobierno de Mora-les dentro y fuera del país.

  20. Trilha ecológica do Cavalo-Marinho: Ecoturismo em Barra Grande/PI

    Directory of Open Access Journals (Sweden)

    Andrea Geisa Pereira Barbosa

    2010-06-01

    Full Text Available Na comunidade Barra Grande, localidade do município de Cajueiro da Praia - PI existe uma trilha ecológica muito bem planejada pelos moradores locais da própria comunidade: A Trilha do Cavalo - Marinho. Essa trilha consiste em um passeio ecológico, onde se trabalham comutantemente o turismo, a sustentabilidade e a educação ambiental.  A área de estudo - a localidade Barra Grande - pertence à Área de Proteção Ambiental (APA do Delta do Parnaíba (APA do Delta do Parnaíba, que visa proteger os ecossistemas costeiros, localizados nos estados do Maranhão, Piauí e Ceará. A referente pesquisa tem como principal objetivo inter-relacionar o termo ecoturismo, educação ambiental, sustentabilidade, e a trilha do cavalo marinho, realizado na pequena localidade do Piauí, Barra Grande. A metodologia utilizada no trabalho em estudo foi pesquisa bibliográfica: constituída de um conjunto de obras escritas referente ao turismo, desenvolvimento sustentável, desenvolvimento local sustentável, meio ambiente e educação ambiental e pesquisa de campo não participativa: realizada para obtenção das informações sobre a situação da área de estudo e analisar os aspectos trabalhados pelos moradores tanto na questão de educação ambiental como da sustentabilidade.

  1. Las cubiertas ecológicas de tercera generación: un nuevo material constructivo

    Directory of Open Access Journals (Sweden)

    Barbero, M.

    2008-09-01

    Full Text Available In 1994, the first ecological roof in Spain was built as a result of a research process. The structure of the construction, the substrate, and the chosen plants have been modified since then, in order to make the environmental properties optimum and to adapt it to extreme climatic conditions such as Spanish dry summers and frosted winters. All these changes have been tested and the energetic attitude has been studied. The best result is represented by a third generation roof model, called as an ecological garden roof. The present article describes the results obtained from the previous research as well as the final process results.En 1994 se inició una investigación que dio como resultado la construcción de la primera cubierta ecológica en España. Desde ese momento se han realizado modificaciones en su estructura constructiva, en el sustrato empleado y en las plantas empleadas, con la intención de optimizar su comportamiento, adaptándola a las condiciones climáticas que se padecen de España. Todas estas modificaciones han sido ensayadas y se ha evaluado rigurosamente su comportamiento energético. El resultado ha culminado en un modelo de cubierta, ya de una tercera generación, denominada como cubierta ecológica jardín. En este artículo se muestran, tanto los resultados de la investigación previa, como los correspondientes a la fase final que culminó con ese nuevo modelo, considerado como un nuevo material constructivo, plenamente sostenible.

  2. Wind Farm Wake: The Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Pierre-Elouan Réthoré

    2013-02-01

    Full Text Available The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surface temperature as well as ground-based information at and near the wind farm, including Supervisory Control and Data Acquisition (SCADA data. The SCADA data reveal that the case of fog formation occurred 12 February 2008 on the 10:10 UTC. The fog formation is due to very special atmospheric conditions where a layer of cold humid air above a warmer sea surface re-condensates to fog in the wake of the turbines. The process is fed by warm humid air up-drafted from below in the counter-rotating swirl generated by the clock-wise rotating rotors. The condensation appears to take place primarily in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog.

  3. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3

    International Nuclear Information System (INIS)

    Kula, Anna; Gharu, Lavina; Marcello, Alessandro

    2013-01-01

    Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

  4. Caffeine Abolishes the Ultraviolet-Induced REV3 Translesion Replication Pathway in Mouse Cells

    Directory of Open Access Journals (Sweden)

    Kouichi Yamada

    2011-11-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a photoproduct on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion. Using an alkaline sucrose density gradient sedimentation technique, we previously classified this process termed UV-induced translesion replication (UV-TLS into two types. In human cancer cells or xeroderma pigmentosum variant (XP-V cells, UV-TLS was inhibited by caffeine or proteasome inhibitors. However, in normal human cells, the process was insensitive to these reagents. Reportedly, in yeast or mammalian cells, REV3 protein (a catalytic subunit of DNA polymerase ζ is predominantly involved in the former type of TLS. Here, we studied UV-TLS in fibroblasts derived from the Rev3-knockout mouse embryo (Rev3KO-MEF. In the wild-type MEF, UV-TLS was slow (similar to that of human cancer cells or XP-V cells, and was abolished by caffeine or MG-262. In 2 cell lines of Rev3KO-MEF (Rev3−/− p53−/−, UV-TLS was not observed. In p53KO-MEF, which is a strict control for Rev3KO-MEF, the UV-TLS response was similar to that of the wild-type. Introduction of the Rev3 expression plasmid into Rev3KO-MEF restored the UV-TLS response in selected stable transformants. In some transformants, viability to UV was the same as that in the wild-type, and the death rate was increased by caffeine. Our findings indicate that REV3 is predominantly involved in UV-TLS in mouse cells, and that the REV3 translesion pathway is suppressed by caffeine or proteasome inhibitors.

  5. Mining the Human Complexome Database Identifies RBM14 as an XPO1-Associated Protein Involved in HIV-1 Rev Function

    OpenAIRE

    Budhiraja, Sona; Liu, Hongbing; Couturier, Jacob; Malovannaya, Anna; Qin, Jun; Lewis, Dorothy E.; Rice, Andrew P.

    2015-01-01

    By recruiting the host protein XPO1 (CRM1), the HIV-1 Rev protein mediates the nuclear export of incompletely spliced viral transcripts. We mined data from the recently described human nuclear complexome to identify a host protein, RBM14, which associates with XPO1 and Rev and is involved in Rev function. Using a Rev-dependent p24 reporter plasmid, we found that RBM14 depletion decreased Rev activity and Rev-mediated enhancement of the cytoplasmic levels of unspliced viral transcripts. RBM14 ...

  6. La huella ecológica del cultivo del olivo en España y su aplicabilidad como indicador de agricultura sostenible

    OpenAIRE

    López Bermúdez, Francisco; Alonso Sarriá, Francisco; Conesa García, Carmelo; Hernández Laguna, Enrique; Álvarez Rogel, Yolanda

    2004-01-01

    El cultivo del olivo ocupa vastas superficies en las tierras mediterráneas constituyendo parte esencial de su paisaje. Es el principal cultivo arbóreo mediterráneo y de España, con grandes repercusiones ecológicas, socio-económicas y culturales. Con el objetivo de determinar la sostenibilidad ecológica del cultivo, y el riesgo de desertificación, se aplica el cálculo del indicador de huella ecológica (HE), se lo compara con la biocapacidad (BP) del olivar en el campo español y ...

  7. La co-conception en partenariat de systèmes agricoles innovants

    Directory of Open Access Journals (Sweden)

    Vall Eric

    2016-01-01

    Full Text Available La co-conception de systèmes agricoles innovants est une piste prometteuse pour répondre au défi de l’innovation, notamment pour les exploitations agricoles familiales africaines confrontées à de multiples changements. Mais il faut penser à la place et aux rôles tenus par de multiples acteurs (agriculteurs, conseillers, chercheurs pour produire les changements souhaités par toutes les parties, et donc réfléchir à la question du partenariat dans le processus. Cet article présente la démarche de conception en partenariat de systèmes agricoles innovants (CPSAI élaborée entre 2005 et 2015 dans l’ouest du Burkina Faso, notamment sur la gestion de la fumure organique des cultures. La CPSAI s’appuie sur un dispositif partenarial formalisé et sur une démarche progressive en trois phases itératives : (1 exploration et formalisation du partenariat, (2 conceptions et test des options de changement, (3 bilan et désengagement. Les résultats obtenus montrent que l’innovation est plus efficace et durable quand elle est le produit d’un travail partenarial.

  8. Aplikace pro nositelnou elektroniku se systémem Apple WatchOS

    OpenAIRE

    Singh, Kevin

    2017-01-01

    Bakalářská práce „Aplikace pro nositelnou elektroniku se systémem Apple WatchOS“ se zabývá teoretickým rozborem komunikací M2M (Machine-to-Machine), H2H (Human- to-Human), D2D (Device-to-Device) a nositelnou elektronikou. V teoretické části jsou dále popsány chytré hodinky Apple Watch, jenž obsahují požadovaný systém WatchOS. V rámci bakalářské práce vznikly dvě aplikace, přičemž první byla vytvořena pro mobilní zařízení iPhone a druhá pro chytré hodinky Apple watch. Aplikace zobrazují inform...

  9. Posouzení stability kotevního systému

    OpenAIRE

    Krško, Matúš

    2012-01-01

    Bakalárska práca je zameraná na problematiku stability kotevného systému. Teoretická časť sa zaoberá rozdelením a technológiou výstavby kotvených stien a poruchovými stavmi, ktoré môžu nastať. Ďalej sú predstavené metódy na posúdenie vnútornej stability systému. Vo výpočtovej časti sú tieto metódy aplikované na vzorový príklad. V závere práce sú získané výsledky vyhodnotené. Bachelor´s thesis is focused on stability of anchored system. Theoretical part deals with various types of anchored ...

  10. Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells

    Energy Technology Data Exchange (ETDEWEB)

    Ramakrishnan, Sathiya N.; Lau, Patrick; Crowther, Lisa M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cleasby, Mark E. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Millard, Susan; Leong, Gary M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cooney, Gregory J. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Muscat, George E.O., E-mail: g.muscat@imb.uq.edu.au [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia)

    2009-10-30

    The nuclear hormone receptor, Rev-erb beta operates as a transcriptional silencer. We previously demonstrated that exogenous expression of Rev-erb{beta}{Delta}E in skeletal muscle cells increased Srebp-1c mRNA expression. We validated these in vitro observations by injection of an expression vector driving Rev-erb{beta}{Delta}E expression into mouse tibialis muscle that resulted in increased Srebp-1c mRNA expression. Paradoxically, Rev-erb{beta} siRNA expression in skeletal muscle cells repressed Srebp-1c expression, and indicated that Rev-erb{beta} expression was necessary for Srebp-1c expression. ChIP analysis demonstrated that Rev-erb{beta} was recruited to the Srebp-1c promoter. Moreover, Rev-erb{beta} trans-activated the Srebp-1c promoter, in contrast, Rev-erb{beta} efficiently repressed the Rev-erb{alpha} promoter, a previously characterized target gene. Finally, treatment with the Rev-erb agonist (hemin) (i) increased the trans-activation of the Srebp-1c promoter by Rev-erb{beta}; and (ii) increased Rev-erb{beta} and Srebp-1c mRNA expression. These data suggest that Rev-erb{beta} has the potential to activate gene expression, and is a positive regulator of Srebp-1c, a regulator of lipogenesis.

  11. Pozice RM-Systému na českém kapitálovém trhu

    OpenAIRE

    Novotný, Josef

    2007-01-01

    Práce popisuje historický vývoj RM-Systému, okolnosti, za kterých byl založen,princip jeho fungování. Popisuje také trhy cenných papírů z teoretického hlediska, jejich dělení a systémy, na kterých fungují. Dále práce popisuje současnou pozici RM-Systému na českém trhu cenných papírů a zkoumá její možné příčiny.

  12. Možnosti vstřikovacího systému common-rail

    OpenAIRE

    Smilek, Tomáš

    2008-01-01

    Tomáš Smilek Možnosti vstřikovacího systému common-rail BP, Ústav automobilního a dopravního inženýrství, 2008, str. 23, obr. 18, přílohy 0 Bakalářská práce se zabývá vstřikovacím systémem common-rail. Popisuje historii vývoje stejně jako jednotlivé části systému a jejich funkci. Také stanovuje výhody oproti starým způsobům vstřikování. Tomáš Smilek Possibilities of Common-rail Injection System BT, Institute of Automotive Engineering, 2008, p. 23, fig. 18, appendices 0 This study´s motivat...

  13. TEN YEARS OF THE NORTHEASTERN NURSING NETWORK JOURNAL - REV RENE: A DREAM COME TRUE

    Directory of Open Access Journals (Sweden)

    Inacia Sátiro Xavier de Franca

    2011-01-01

    Full Text Available Objetivou-se analisar a memória histórica da Rev Rene ao longo de uma década de sua existência destacando a sua organização, a produção científica e as conquistas alcançadas no concernente a sua indexação nas bases de dados. Estudo fenomenológico cujos dados foram coletados por meio de um formulário, submetidos a associações livres e interpretados em consonância com “A poética do espaço”. Os núcleos foram: Universidade Federal do Ceará (UFC — A casa da Rev Rene; A Rev Rene — ninho — um espaço aberto aos pesquisadores da Saúde e áreas afins; Poética das gavetas do cofre e dos armários — o capital científico da Rev Rene à disposição dos leitores; A Rev Rene — concha — uma homologia poética; A Rev Rene é redonda — Metas e ações para a projeção no cenário nacional e internacional. A Rev Rene transpôs a dimensão do sonho e consolidou-se como um lócus de ciência.

  14. Cuidado ecológico: o significado para profissionais de um hospital geral Cuidado ecológico: el significado para profesionales de un hospital general Ecological care: meaning for health care professionals from a general hospital

    Directory of Open Access Journals (Sweden)

    Marli Terezinha Stein Backes

    2009-01-01

    Full Text Available OBJETIVO: Compreender à luz do pensamento complexo, o significado do cuidado ecológico e como este vem sendo associado à prática de profissionais que trabalham em um hospital geral. MÉTODOS: Estudo descritivo de natureza qualitativa realizado com 15 profissionais que atuam em três diferentes setores: Serviço de Lavanderia, Serviço de Nutrição e uma Unidade de Internação. Os dados foram coletados por meio de um questionário semi-estruturado e submetidos à análise de conteúdo proposta por Bardin. RESULTADOS: As categorias encontradas foram: Significando o cuidado ecológico, Salientando a importância do cuidado ecológico para a prática profissional e Medidas preventivas em saúde associadas ao cuidado ecológico. CONCLUSÕES: O estudo evidenciou que existe uma preocupação geral, ainda que incipiente, a respeito da problemática ambiental. A preocupação principal está relacionada à separação, reciclagem e destino adequado do lixo, mesmo que alguns profissionais tenham sinalizado para a importância de medidas preventivas como a lavagem das mãos, utilização de produtos biodegradáveis, entre outros.OBJETIVO: Comprender a La luz del pensamiento complejo, el significado del cuidado ecológico y cómo éste viene siendo asociado a la práctica de profesionales que trabajan en un hospital general. MÉTODOS: Estudio descriptivo de naturaleza cualitativa realizado con 15 profesionales que actúan en tres diferentes sectores: Servicio de Lavandería, Servicio de Nutrición y una Unidad de Internamiento. Los datos fueron recolectados por medio de un cuestionario semi-estructurado y sometidos al análisis de contenido propuesto por Bardin. RESULTADOS: Las categorías encontradas fueron: Significando el cuidado ecológico, resaltando la importancia del cuidado ecológico para la práctica profesional y Medidas preventivas en salud asociadas al cuidado ecológico. CONCLUSIONES: El estudio evidenció que existe una preocupaci

  15. Géographie de l´Ecole et géographie à l´Ecole. (Etude du fichier des thèses de 1990 à 1994.)

    OpenAIRE

    Chevalier, Jean-Pierre

    1997-01-01

    La décennie des années 90 est marquée par un développement des travaux de thèses en géographie portant soit sur l´Ecole, soit sur la didactique de la discipline. Certaines font de l´Ecole un objet géographique, d´autres étudient l´enseignement de la géographie, ce sont ces dernières qui relèvent de préoccupations plus proprement didactiques. Nous distinguons donc “géographie de l´Ecole” et “géographie à l´Ecole”. Nous avons étudié le fichier des thèses soutenues et des sujets de thèses dépos...

  16. Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

    Directory of Open Access Journals (Sweden)

    Ryan D. Welch

    2017-07-01

    Conclusions: Disrupting Rev-Erb activity in injured muscle accelerates regenerative muscle repair/differentiation through transcriptional de-repression of myogenic programs. Rev-Erb, therefore, may be a potent therapeutic target for a myriad of muscular disorders.

  17. Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation

    Directory of Open Access Journals (Sweden)

    Jun Takezawa

    2010-01-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a lesion on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion, extend by a few nucleotides, and dissociate from the 3′-OH. The replicative polymerase then resumes DNA synthesis. This process, termed translesion replication (TLS or replicative bypass, may involve at least five different polymerases in mammals, although the participating polymerases and their roles have not been entirely characterized. Using siRNAs originally designed and an alkaline sucrose density gradient sedimentation technique, we verified the involvement of several polymerases in ultraviolet (UV light-induced TLS in HeLa cells. First, siRNAs to Rev3 or Rev7 largely abolished UV-TLS, suggesting that these 2 gene products, which comprise Polζ, play a main role in mutagenic TLS. Second, Rev1-targeted siRNA also abrogated UV-TLS, indicating that Rev1 is also indispensable to mutagenic TLS. Third, Polη-targeted siRNA also prevented TLS to a greater extent than our expectations. Forth, although siRNA to Polι had no detectable effect, that to Polκ delayed UV-TLS. To our knowledge, this is the first study reporting apparent evidence for the participation of Polκ in UV-TLS.

  18. O marketing ecológico como vantagem competitiva Green marketing as a competitive advantage

    Directory of Open Access Journals (Sweden)

    Sérgio Luís Stirbolov Motta

    2007-06-01

    Full Text Available A competição entre as organizações existe basicamente porque um ou mais players atuais ou potenciais, de um determinado setor econômico, percebem a oportunidade de melhorar sua posição (ou estabelecê-la ou se sentem pressionados por outro player, ou seja, os movimentos de uma empresa repercutem nas demais, numa relação de interdependência. Dessa forma, é constante a busca por alternativas que permitam o desenvolvimento empresarial. Este trabalho aponta um caminho que há algum tempo vem sendo percorrido por empresas, mas apenas nos últimos anos vem ganhando destaque nos meios de comunicação e na consciência dos indivíduos: a gerência de ações de marketing ecológico. A partir dos dados de uma pesquisa exploratória realizada na cidade de São Paulo e dos modelos de vantagem competitiva de Porter e de D'Aveni, pôde-se constatar que a prática de marketing ecológico pelas empresas pode constituir vantagem competitiva, não obstante o fato de esse fenômeno não ocorrer atualmente, pois tanto o conhecimento sobre as questões ambientais quanto as atitudes positivas em relação à preservação ambiental já estão presentes nos consumidores.Organizational competition exists because players or potential ones in an economic sector perceive an opportunity to improve or establish their position and may feel pressured by others. Therefore actions of one company have repercussions on the others, disclosing interdependence. As such, there is a constant pursuit for alternatives that foster company development. This article highlights the management of ecological marketing, an approach that companies have accompanied for some time and which only in recent years has attracted the attention of media and individuals. Based upon an exploratory survey made in the city of São Paulo as well as models of competitive advantage by Porter and D'Aveni, it was shown that green marketing may be of advantage. Although this is not a current practice

  19. Sustentabilidade: mantra ou escolha moral? uma abordagem ecológico-econômica

    Directory of Open Access Journals (Sweden)

    Clóvis Cavalcanti

    2012-01-01

    Full Text Available Qual é o tamanho ótimo da escala econômica que a natureza pode admitir? A questão requer que se esteja falando de uma situação em que a economia seja vista como subsistema do ecossistema. É assim que a economia ecológica percebe a realidade e é nessa óptica que se configura o conceito de sustentabilidade ecológica. O impacto ambiental do crescimento sobre os recursos e sumidouros da natureza tem que ser contido dentro de limites. A noção usual de sustentabilidade, porém, dá a impressão de se ter convertido numa espécie de mantra da atualidade, sem maior compromisso. Mudanças no sistema econômico são inevitáveis como forma de adaptação às restrições que o processo econômico confronta. Cabe indagar o que é que se deseja sustentar e em que escala de tempo. À sociedade cumpre escolher a mudança a se fazer: uma escolha moral.What is the optimum scale of the economy compatible with nature? This question asks for consideration of the economy as a subsystem of the ecosystem. Ecological economics adopts that perspective permitting that the concept of environmental sustainability be established. This implies that the environmental impact of growth on the source and sink functions of nature be contained within limits. The usual notion of sustainability, however, gives the impression of having been transformed into a kind of today's mantra, without serious obligations. Changes in the economic system are unavoidable as a means of adaptation to the restrictions that the economic process encounters. This requires knowing what it is to be sustained and in within which time scale. The duty of choosing the changes to be made must be ascribed to society: a moral choice.

  20. Metabolismo urbano y apropiación de excedentes ecológicos. De la estepa a la arquitectura burguesa

    Directory of Open Access Journals (Sweden)

    Luis Inostroza Pino

    2014-05-01

    Esta relación entre sociedad y naturaleza, dejó profundas huellas de organización y complejidad en Punta Arenas, conectada metabólicamente con las formas de explotación territorial y apropiación de la estepa. El coirón patagónico y la arquitectura burguesa, principio y fin de la misma cadena productiva, corresponden a las fases inicial y terminal de un proceso de apropiación social de los excedentes ecológicos. Como flujo metabólico, el excedente es ecológico en su origen y social en su evolución.

  1. Dimensiones ecológicas de la familia: La situación social de los niños

    Directory of Open Access Journals (Sweden)

    Réjean Tessier

    1994-06-01

    Full Text Available El artículo trata de la situación social de las familias y los niños. El autor usa el paradigma ecológico que intenta comprender el comportamiento como la resultante de un intercambio mutuo y recíproco entre el organismo y el medio. Partiendo de datos estadísticos de la OMS y UNICEF trata de demostrar las consecuencias posibles de ciertas situaciones sociales y del contexto demográfico sobre las oportunidades de desarrollo de los niños. Se destaca la importancia de los diferentes niveles de las dimensiones ecológicas de la familia y se alerta sobre los efectos nocivos que tienen en los niños la pobreza extrema y las condiciones familiares de gran adversidad.

  2. CH4 IPDA Lidar mission data simulator and processor for MERLIN: prototype development at LMD/CNRS/Ecole Polytechnique

    Science.gov (United States)

    Olivier, Chomette; Armante, Raymond; Crevoisier, Cyril; Delahaye, Thibault; Edouart, Dimitri; Gibert, Fabien; Nahan, Frédéric; Tellier, Yoann

    2018-04-01

    The MEthane Remote sensing Lidar missioN (MERLIN), currently in phase C, is a joint cooperation between France and Germany on the development of a spatial Integrated Path Differential Absorption (IPDA) LIDAR (LIght Detecting And Ranging) to conduct global observations of atmospheric methane. This presentation will focus on the status of a LIDAR mission data simulator and processor developed at LMD (Laboratoire de Météorologie Dynamique), Ecole Polytechnique, France, for MERLIN to assess the performances in realistic observational situations.

  3. Bacterial growth efficiency in the tropical estuarine and coastal waters of Goa, southwest coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Ram, A.; Nair, S.; Chandramohan, D.

    overview. Mar Ecol Prog Ser 43:1-10 8. Del Giorgio PA, Cole 11 (1998) Bacterial growth efficiency in natural aquatic ecosystems. Annu Rev Ecol Syst 29:503 541 9. Del Giorgio PA, Cole n (2000) Bacterial energetics and growth efficiency. In: DL Kirchman (ed...) Microbial Ecology of the Oceans. Wiley-Liss, New York pp289~325 10. Del Giorgio PA, Gasol JM, Mura P, Vaque D, Duarte CM (1996) Protozoan control of the proportion of metabolically active bacteria in coastal marine plankton. Limnol Oceanogr 41:1169-1179 11...

  4. Test en ligne des systèmes à base de microprocesseur

    OpenAIRE

    Michel , Thierry

    1993-01-01

    Cette thèse traite de la vérification en ligne, par des moyens matériels, du flot de contrôle d'un système a base de microprocesseur. Une technique de compaction est utilisée pour faciliter cette vérification (analyse de signature). La plupart des méthodes proposées jusqu'ici imposent une modification du programme d'application, afin d'introduire dans celui-ci des propriétés invariantes (la signature en chaque point de l'organigramme est indépendante des chemins préalablement parcourus). Les ...

  5. Simulation of rice yield under different irrigation and nitrogen application managements by CropSyst model

    Directory of Open Access Journals (Sweden)

    Narjes ZARE

    2015-12-01

    Full Text Available The aim of this study was the calibration and validation of CropSyst model for rice in the city of Rasht. The necessary data were extracted from a field experiment which was carried out during 2005-2007 in a split-plot design. The main plots were irrigation regimes including continuous flooding irrigation and 5-day irrigation intervals. The subplots consisted of four nitrogen levels: zero N application, 45, 60 and 75 kg N ha-1. Normalized Root Mean Squared Error (nRMSE and Residual Mass Coefficient (Crm in calibration years were 9.3 % and 0.06, respectively. In validation year, nRMSE and Crm were 9.7 % and 0.11, respectively. According to other indices to assess irrigation regimes and fertilizer levels, the most suitable treatments regarding environmental aspect were 5-day irrigation regime and 45 kg N ha-1.

  6. Automatizace chyb objednávkového systému

    OpenAIRE

    Bažant, Milan

    2007-01-01

    Bakalářská práce se zabývá vytvořením softwaru pro automatizaci oprav integračních chyb objednávkového systému. Na základě analýzy chyb, jejich příčin a možnostech opravy zajistit automatizaci opravy tak, aby nebyl potřeba ruční zásah a nedocházelo ke zpoždění realizace objednávek zákazníků. The bachelor thesis focuses on the creation of the automatic error cleansing software which clears the errors generated by the ordering system. Based on the error analysis (e.g. their causes and possib...

  7. Systèmes de type radar appliqués aux domaines routiers et ferroviaires

    OpenAIRE

    DELOOF, P; GHYS, JP; RIVENQ, A; HAESE, N; SAINT-VENANT, M

    2001-01-01

    La détection d'obstacles par radar peut s'appliquer aussi bien au domaine des transports routiers qu'à ceux des transports en commun. Quelques uns de ces systèmes sont étudiés au LEOST dans le cadre du GRRT, Groupement Régional Nord Pas-de-Calais pour la Recherche dans les Transports. La plupart des capteurs micro-ondes furent réalisés par le DHS. Ils étaient fondés soit sur la modulation linéaire en fréquence (FMCW) soit sur la modulation par impulsions. Ces études ont mené à la réalisation ...

  8. Teede REV-2 otsustas börsile minna / Gea Velthut-Sokka

    Index Scriptorium Estoniae

    Velthut-Sokka, Gea, 1977-

    2004-01-01

    Eelmise aasta edukaima ehitusfirma Teede REV-2 ja tema suurinvestori Alta Kapital esindajad põhjendavad börsile mineku otsust. Tabelid ja diagrammid: Veerandi aktsiate omanikuvahetus börsilemineku peaprooviks

  9. REV ÜRÜNLERİN MUHASEBELEŞTİRİLMESİ

    OpenAIRE

    YURT, Eda

    2009-01-01

    Eda, Yurt, Türev Ürünlerin Muhasebelestirilmesi, Tezsiz Yüksek Lisans Dönem Projesi,Danısman: Doç. Dr. Kadir Gürdal, 58 s.BİTİRME PROJESİ ÖZETİProje finansal araçlar olarak türev ürünlerin muhasebelestirilmesine iliskinstandartların incelenmesini amaçlamaktadır. Öncelikle finansal risk tanımlanmıstır.Daha sonra türev piyasaların tarihi anlatılmıs ve islem gördükleri piyasalara göresınıflandırılmıstır. Bu temel açıklamalar sonrasında türev ürünler için UluslararasıMuhasebe Standartları incelen...

  10. The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes

    International Nuclear Information System (INIS)

    Fang Jianhua; Acheampong, Edward; Dave, Rajnish; Wang Fengxiang; Mukhtar, Muhammad; Pomerantz, Roger J.

    2005-01-01

    Productive infection by human immunodeficiency virus type I (HIV-1) in the central nervous system (CNS) involves mainly macrophages and microglial cells. A frequency of less than 10% of human astrocytes is estimated to be infectable with HIV-1. Nonetheless, this relatively low percentage of infected astrocytes, but associated with a large total number of astrocytic cells in the CNS, makes human astrocytes a critical part in the analyses of potential HIV-1 reservoirs in vivo. Investigations in astrocytic cell lines and primary human fetal astrocytes revealed that limited HIV-1 replication in these cells resulted from low-level viral entry, transcription, viral protein processing, and virion maturation. Of note, a low ratio of unspliced versus spliced HIV-1-specific RNA was also investigated, as Rev appeared to act aberrantly in astrocytes, via loss of nuclear and/or nucleolar localization and diminished Rev-mediated function. Host cellular machinery enabling Rev function has become critical for elucidation of diminished Rev activity, especially for those factors leading to RNA metabolism. We have recently identified a DEAD-box protein, DDX1, as a Rev cellular co-factor and now have explored its potential importance in astrocytes. Cells were infected with HIV-1 pseudotyped with envelope glycoproteins of amphotropic murine leukemia viruses (MLV). Semi-quantitative reverse transcriptase-polymerase chain reactions (RT-PCR) for unspliced, singly-spliced, and multiply-spliced RNA clearly showed a lower ratio of unspliced/singly-spliced over multiply-spliced HIV-1-specific RNA in human astrocytes as compared to Rev-permissive, non-glial control cells. As well, the cellular localization of Rev in astrocytes was cytoplasmically dominant as compared to that of Rev-permissive, non-glial controls. This endogenous level of DDX1 expression in astrocytes was demonstrated directly to lead to a shift of Rev sub-cellular distribution dominance from nuclear and/or nucleolar to

  11. La perspectiva ecológica y la hipermediatización social

    Directory of Open Access Journals (Sweden)

    Eduardo Andrés Vizer

    2015-01-01

    Full Text Available La “ecología” de los medios no debe ser concebida como una especie de entorno que nos rodea y del cual somos el “centro”, sino como un sistema de producción, circulación y consumo en el cual son los individuos, en tanto consumidores y (realimentadores del sistema, los que conforman su “entorno”. Un abordaje ecológico de los medios tradicionales (radio, cine y televisión introduce a los públicos consumidores como su entorno, y no al contrario (¿quién consume a quién?. Un entorno, un mercado que a través de prácticas de consumo realimenta al sistema de medios. Por otro lado, en los sistemas digitales, todos somos parte de él, no hay entorno externo, y cada acto de consumo es igualmente un acto de circulación y de producción. Para conocer la incidencia profunda de un dispositivo técnico (sea hard o soft, debemos indagar sobre las múltiples dimensiones interligadas e interactivas dentro del ambiente en el que opera: poder, resistencias, tiempo y espacio, socialidades, lenguajes, símbolos.

  12. Think first job! Preferences and expectations of engineering students in a French `Grande Ecole'

    Science.gov (United States)

    Gerwel Proches, Cecile N.; Chelin, Nathalie; Rouvrais, Siegfried

    2018-03-01

    A career in engineering may be appealing owing to the prospect of a good salary and a dynamic work environment. There may, however, be challenges for students wishing to enter their first job. In engineering education, career preparation courses may be included so as to prepare students adequately for their first job, future careers, and to reinforce career decision-making skills. This study explored the first-job preferences and expectations of engineering students at a generalist French 'Grande Ecole' before their compulsory internship. The study ultimately provided insight into ways in which future engineers may best be equipped for their first jobs. A qualitative research study was employed, using four focus groups to collect data, which was analysed thematically. Key findings indicate the resolute importance that engineering students place on having a challenging job, teamwork, independence, opportunities for development, and a participative style of being managed. The research findings may be of value in order to renew an engineering curriculum with better alignment between students' expectations and industry needs.

  13. Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation

    Science.gov (United States)

    Amador, Ariadna; Huitron-Resendiz, Salvador; Roberts, Amanda J.; Kamenecka, Theodore M.; Solt, Laura A.; Burris, Thomas P.

    2016-01-01

    The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery that regulates the circadian clock. The identical core clock machinery regulates myriad endocrine and metabolic functions providing a link between sleep and metabolic health. The REV-ERBs (REV-ERBα and REV-ERBβ) are nuclear receptors that are key regulators of the molecular clock and have been successfully targeted using small molecule ligands. Recent studies in mice suggest that REV-ERB-specific synthetic agonists modulate metabolic activity as well as alter sleep architecture, inducing wakefulness during the light period. Therefore, these small molecules represent unique tools to extensively study REV-ERB regulation of sleep and wakefulness. In these studies, our aim was to further investigate the therapeutic potential of targeting the REV-ERBs for regulation of sleep by characterizing efficacy, and optimal dosing time of the REV-ERB agonist SR9009 using electroencephalographic (EEG) recordings. Applying different experimental paradigms in mice, our studies establish that SR9009 does not lose efficacy when administered more than once a day, nor does tolerance develop when administered once a day over a three-day dosing regimen. Moreover, through use of a time response paradigm, we determined that although there is an optimal time for administration of SR9009 in terms of maximal efficacy, there is a 12-hour window in which SR9009 elicited a response. Our studies indicate that the REV-ERBs are potential therapeutic targets for treating sleep problems as those encountered as a consequence of shift work or jet lag. PMID:27603791

  14. Systèmes d'information sur la santé Transposer les données ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    28 mars 2013 ... Au pire, un système d'information sur la santé dysfonctionnel peut entraîner la non-satisfaction des besoins fondamentaux de la population. Briser le ... Five IDRC-supported health systems researchers talk about how their work is improving primary health care for mothers and children, and changin.

  15. PLC SCADA systém pro řízení větrného tunelu

    OpenAIRE

    Trenčan, Tomáš

    2017-01-01

    Předložená bakalářská práce se věnuje programovatelnému automatu (PLC) firmy WAGO a SCADA systémům. Skládá se ze dvou části, z teoretické části a z praktické části. V teoretické části jsou na zakladě poznatků z odborné literatury vymezeny pojmy ohledně SCADA systémů, PLC od firmy WAGO a vývojového prostředí e!COCKPIT firmy WAGO a rešerše volně dostupných SCADA systémů podporujících Modbus TCP. Na základě této rešerše byl vybrán SCADA systém pro vizualizaci dvou demonstračníc úloh v praktické ...

  16. Applications des techniques de diffusion de la lumière, des rayons X et des neutrons a l'étude des systèmes colloïdaux. Troisième partie : caractérisation des microémulsions et des composés solides. Étude de différents systèmes d'intérêt industriel Application of Light, X-Ray and Neutron Diffusion Techniques to the Study of Colloidal Systems. Part Three: Microemulsions, Solid Materials, Liquids and Miscellaneous Systems with Industrial Uses

    Directory of Open Access Journals (Sweden)

    Espinat D.

    2006-11-01

    Full Text Available Cette troisième partie clôt une revue bibliographique concernant la caractérisation des systèmes colloïdaux par les techniques de diffusion (lumière, rayons X, neutrons (Rev. Inst. Franç. du Pétrole, Vol. 45, No 6, novembre-décembre 1990. Nous poursuivrons cette présentation en nous intéressant aux microémulsions. Après la présentation des informations que l'on peut obtenir sur les systèmes polymériques, les solutions micellaires ou les systèmes fractals, qui ont fait l'objet de multiples travaux, nous reviendrons sur les applications plus restreintes à des systèmes colloïdaux parfois moins bien définis et d'origine industrielle, telles les fractions lourdes des pétroles, les asphaltènes ou encore les additifs de lubrification. Les possibilités de la diffusion des rayons X et des neutrons à l'étude de matériaux solides seront présentées à travers la caractérisation des solides poreux et en particulier des catalyseurs. Nous terminerons cette présentation par les liquides purs ou les mélanges; les techniques de diffusion ont contribué fortement à la description des structures des phases liquides. This article is the second one (the first one was published in Revue de l'Institut Français du Pétrole No. 6, November-December 1990 concerning the application of techniques of light scattering, X rays and neutrons to the analysis of colloidal systems and more specifically to the theoretical description of the three methods. The aim of this second part is to make a nonexhaustive description of several fields of applications. A special effort is made to describe the potential of these methods for characterizing colloidal or divided systems encountered in a great many activities involving the petroleum industry. The first part of this article takes up polymer and colloidal solutions. Particular attention is paid to the importance of scattering techniques for characterizing polymers in solution and micellar solutions. A

  17. Offshore wind farms in the local environment - an examination at Horns Rev Offshore Wind Farm. Background report; Havvindmoeller i lokalomraadet - en undersoegelse ved Horns Rev Havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, Susanne

    2005-07-01

    Horns Rev Offshore Wind Farm was built in 2002. A presentation is made of a sociological, qualitative survey on the local community's reception of the offshore wind farm. The survey aims at identifying attitudes towards the farm before and after the construction, with a view to identifying possible changes in attitudes, and explain the reasons for these (ml)

  18. Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking.

    Directory of Open Access Journals (Sweden)

    Min-Hsuan Lin

    Full Text Available Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. Here we investigate the mechanism of this effect for the first time, establishing that redistribution of Rev by Nullbasic is not due to direct interaction between the two proteins. Rather, Nullbasic affects subcellular localization of cellular proteins that regulate Rev trafficking. In particular, Nullbasic induced redistribution of exportin 1 (CRM1, nucleophosmin (B23 and nucleolin (C23 from the nucleolus to the nucleus when Rev was coexpressed, but never in its absence. Inhibition of the Rev:CRM1 interaction by leptomycin B or a non-interacting RevM10 mutant completely blocked redistribution of Rev by Nullbasic. Finally, Nullbasic did not inhibit importin β- or transportin 1-mediated nuclear import, suggesting that cytoplasmic accumulation of Rev was due to increased export by CRM1. Overall, our data support the conclusion that CRM1-dependent subcellular redistribution of Rev from the nucleolus by Nullbasic is not through general perturbation of either nuclear import or export. Rather, Nullbasic appears to interact with and disrupt specific components of a Rev trafficking complex required for its nucleocytoplasmic shuttling and, in particular, its nucleolar accumulation.

  19. Análisis ecológico de la flora de dos parcelas pirenaicas de seguimiento de los ecosistemas forestales.

    Directory of Open Access Journals (Sweden)

    Madotz, N.

    2005-12-01

    Full Text Available Plants with hermaphrodite flowers show a trade-off in resource allocation to male and female functions of reproduction. Such a balance can be conditioned by several factors. One of them seems to be pollination vector. Thalictrum is a genus with species that use different ways of pollination. So that we have investigated the resource allocation patterns to each function (male and female among five species with different pollination vectors. Allocation has been mesured as dry weight of the different flower structures. We have found a significative trend, male function relative investment is bigger in anemophilous than entomophilous among the flve studied species: Th. macrocarpum (wind pollinated, Th. Minus (zoind pollinated, Th. Aquilegiifolium (insect pollinated, Th. tuberosum (insect pollinated and Th. flavum (insect pollinated. During bloom, the androecium has the the greater biomass in these five species, but when all the reproductive process is taken in account, fruits reach higher values. Furthermore, this temporal separation of the maximum allocation to each function would be a way to make competence for the same limited resources weaker.

    [fr]
    La végétation de deux placettes permanentes de suivi des écosystèmes forestiers (23Qf: chênaie; 24Ps: pinède-sapinière situées dans les Pyrénées occidentales a été échantillonnée pendant un an, afin d'analyser les types biologiques et chorologiques et de caractériser son état actuel d'après le Système de Valeurs Indicatrices d'Ellenberg. Les valeurs moyennes obtenues pour chacun des facteurs et le pourcentage des taxons correspondant à chacune des valeurs ont été comparés pour assurer qu 'elles montrent des différences entre placettes ainsi qu'entre les différents habitats de la placette 24Ps. Puisque les valeurs moyennes de la flore sont liées à d'autres caractéristiques de la végétation, elles pourraient être

  20. Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function

    Directory of Open Access Journals (Sweden)

    St-Laurent Georges

    2006-11-01

    Full Text Available Abstract Background The HIV Rev protein is known to facilitate export of incompletely spliced and unspliced viral transcripts to the cytoplasm, a necessary step in virus life cycle. The Rev-mediated nucleo-cytoplasmic transport of nascent viral transcripts, dependents on interaction of Rev with the RRE RNA structural element present in the target RNAs. The C-terminal variant of dsRNA-binding nuclear protein 90 (NF90ctv has been shown to markedly attenuate viral replication in stably transduced HIV-1 target cell line. Here we examined a mechanism of interference of viral life cycle involving Rev-NF90ctv interaction. Results Since Rev:RRE complex formations depend on protein:RNA and protein:protein interactions, we investigated whether the expression of NF90ctv might interfere with Rev-mediated export of RRE-containing transcripts. When HeLa cells expressed both NF90ctv and Rev protein, we observed that NF90ctv inhibited the Rev-mediated RNA transport. In particular, three regions of NF90ctv protein are involved in blocking Rev function. Moreover, interaction of NF90ctv with the RRE RNA resulted in the expression of a reporter protein coding sequences linked to the RRE structure. Moreover, Rev influenced the subcellular localization of NF90ctv, and this process is leptomycin B sensitive. Conclusion The dsRNA binding protein, NF90ctv competes with HIV Rev function at two levels, by competitive protein:protein interaction involving Rev binding to specific domains of NF90ctv, as well as by its binding to the RRE-RNA structure. Our results are consistent with a model of Rev-mediated HIV-1 RNA export that envisions Rev-multimerization, a process interrupted by NF90ctv.

  1. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

    Directory of Open Access Journals (Sweden)

    Gwendal Le Martelot

    2009-09-01

    Full Text Available In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coordinated by the circadian timing system. Molecular clocks are thought to rely on negative feedback loops in clock gene expression that engender oscillations in the accumulation of transcriptional regulatory proteins, such as the orphan receptor REV-ERBalpha. Circadian transcription factors then drive daily rhythms in the expression of clock-controlled output genes, for example genes encoding enzymes and regulators of cellular metabolism. To gain insight into clock output functions of REV-ERBalpha, we carried out genome-wide transcriptome profiling experiments with liver RNA from wild-type mice, Rev-erbalpha knock-out mice, or REV-ERBalpha overexpressing mice. On the basis of these genetic loss- and gain-of-function experiments, we concluded that REV-ERBalpha participates in the circadian modulation of sterol regulatory element-binding protein (SREBP activity, and thereby in the daily expression of SREBP target genes involved in cholesterol and lipid metabolism. This control is exerted via the cyclic transcription of Insig2, encoding a trans-membrane protein that sequesters SREBP proteins to the endoplasmic reticulum membranes and thereby interferes with the proteolytic activation of SREBPs in Golgi membranes. REV-ERBalpha also participates in the cyclic expression of cholesterol-7alpha-hydroxylase (CYP7A1, the rate-limiting enzyme in converting cholesterol to bile acids. Our findings suggest that this control acts via the stimulation of LXR nuclear receptors by cyclically produced oxysterols. In conclusion, our study suggests that rhythmic cholesterol and bile acid metabolism is not just driven by alternating feeding-fasting cycles, but also by REV-ERBalpha, a component of the circadian clockwork circuitry.

  2. Laudato Si” La Encíclica ecológica

    Directory of Open Access Journals (Sweden)

    Luz Bettina Villalobos

    2015-07-01

    Full Text Available El pasado 18 de junio el Papa Francisco de la iglesia Católica Romana, dio a conocer la Encíclica “ Laudato Si” (Alabado sea el Creador, tomado del Cántico de las Criaturas de San Francisco de Asís, reconocido como el patrono de la Ecología. Esta Carta Magisterial, representa un llamado de atención no solo a los cristianos católicos, sino a todos sin importar credo religioso o raza, pues es el llamado a recordar que este planeta es el único que habitamos, es el único que tenemos y que nuestra permanencia en él como humanidad, depende de cuánto lo respetemos y cuidemos. Más que una visión ecológica del grave problema que afrenta la humanidad por el calentamiento global, contaminación de las aguas, agotamiento de las tierras cultivables, es que toda esta problemática recae en una buena parte de la población más pobre del planeta. Urge por lo tanto un cambio de ruta en la vida de los humanos que nos permita ofrecer a las generaciones futuras un lugar habitable, limpio, en paz. Es por ello que esta encíclica propone un diálogo entre todos para afrontar y resolver los problemas que no distinguen, entre países, religiones o razas. Es una gran convocatoria a todo el mundo en pro del cuidado de la Naturaleza, la fragilidad de las interrelaciones que existen entre los factores bióticos y abióticos, que permiten la sustentabilidad de la vida y su evolución

  3. Le système de l'harmonie de Rameau dans sa correspondance avec d'Alembert et Rousseau

    Directory of Open Access Journals (Sweden)

    Stefanović Ana M.

    2002-01-01

    Full Text Available (francuski L'article examine la correspondance polémique de Rameau avec d'Alembert et Rousseau, entretenue dans la sixième décénie du XVIIIe siècle. Le système de l'harmonie de Rameau y est affronté à deux défis contradictoires: d'un côté, à la provocation d'absolutisation du système venant de son intériorité-même, et de l'autre, à une nouvelle conception de l'autonomie musicale, conçue sur le geste anarchique et destructif envers lui. Tandis que, de la polémique avec d'Alembert, le système vient de ressortir assuré et renforcé, soutenant la suprématie de la musique dans le champ théorique, la polémique avec Rousseau démontre que l'autonomie scientifique n'entraîne pas de soi l'isolation de la musique dans le domaine esthétique. Fondé sur le réseau cohérent de ses propres règles, le système musical est apte de se plier, de se modifier sous l'influence de ce qui lui est "extérieur": du sens contenu dans des énoncés linguistiques. L'idée de représentation musicale est alors modifiée dans la direction d'une réconcilliation possible de la raison (cartésienne et de l'imagination créatrice, du général et du particulier, de la norme et de l'individualité, dans la mesure où le système musical devenant analogue au système linguistique, en tant que "langue en action" participe chaque fois dans l'événement de sa propre création.

  4. Contributions of individual domains to function of the HIV-1 Rev response element.

    Science.gov (United States)

    O'Carroll, Ina P; Thappeta, Yashna; Fan, Lixin; Ramirez-Valdez, Edric A; Smith, Sean; Wang, Yun-Xing; Rein, Alan

    2017-08-16

    The HIV-1 Rev response element (RRE) is a 351-base element in unspliced and partially spliced viral RNA; binding of the RRE by the viral Rev protein induces nuclear export of RRE-containing RNAs, as required for virus replication. It contains one long, imperfect double helix (domain I), one branched domain (domain II) containing a high-affinity Rev-binding site, and two or three additional domains. We previously reported that the RRE assumes an "A" shape in solution and suggested that the location of the Rev binding sites in domains I and II, opposite each other on the two legs of the A, is optimal for Rev binding and explains Rev's specificity for RRE-containing RNAs. Using SAXS and a quantitative functional assay, we have now analyzed a panel of RRE mutants. All the results support the essential role of the A shape for RRE function. Moreover, they suggest that the distal portion of domain I and the three crowning domains all contribute to the maintenance of the A shape. Domains I and II are necessary and sufficient for substantial RRE function, provided they are joined by a flexible linker that allows the two domains to face each other. IMPORTANCE Retroviral replication requires that some of the viral RNAs transcribed in the cell nucleus be exported to the cytoplasm without being spliced. To achieve this, HIV-1 encodes a protein, Rev, which binds to a complex, highly structured element within viral RNA, the Rev Response Element (RRE), and escorts RRE-containing RNAs from the nucleus. We previously reported that the RRE is "A"-shaped and suggested that this architecture, with the 2 legs opposite one another, can explain the specificity of Rev for the RRE. We have analyzed the functional contributions of individual RRE domains, and now report that several domains contribute, with some redundancy, to maintenance of the overall RRE shape. The data strongly support the hypothesis that the opposed placement of the 2 legs is essential for RRE function. Copyright © 2017

  5. B23/nucleophosmin interacts with bovine immunodeficiency virus Rev protein and facilitates viral replication.

    Science.gov (United States)

    Passos-Castilho, Ana Maria; Marchand, Claude; Archambault, Denis

    2018-02-01

    The bovine immunodeficiency virus (BIV) Rev shuttling protein contains nuclear/nucleolar localization signals and nuclear import/export mechanisms that are novel among lentivirus Rev proteins. Several viral proteins localize to the nucleolus, which may play a role in processes that are essential to the outcome of viral replication. Although BIV Rev localizes to the nucleoli of transfected/infected cells and colocalizes with one of its major proteins, nucleophosmin (NPM1, also known as B23), the role of the nucleolus and B23 in BIV replication remains to be determined. Here, we demonstrate for the first time that BIV Rev interacts with nucleolar phosphoprotein B23 in cells. Using small interfering RNA (siRNA) technology, we show that depletion of B23 expression inhibits virus production by BIV-infected cells, indicating that B23 plays an important role in BIV replication. The interaction between Rev and B23 may represent a potential new target for the development of antiviral drugs against lentiviruses. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Implicancias ecológicas de la priorización económica en el paisaje cultural. Determinante de orden y sustentabilidad

    Directory of Open Access Journals (Sweden)

    Diego Subercaseaux-Ugarte

    2013-01-01

    Full Text Available La aproximación sistémica y la transdisciplinariedad son fundamentales para tratar la situación ecológica-territorial actual. El paisaje cultural corresponde a un objeto de estudio epistemológicamente adecuado ante la problemática de la sustentabilidad. La racionalidad económica prioriza la maximización del lucro económico frente al diseño del paisaje cultural (dimensión económica. Se definen 16 principios propios del determinante de orden económico, donde se identifican sus efectos en la estructura del paisaje y las consecuencias ecológicas. Sucede una disminución de la conectividad y de la diversidad ecológica del paisaje cultural, de su potencial de resiliencia y restauración, un desacoplamiento entre la autopoiesis y la adaptación, y así una disminución de su adaptabilidad ecológica. Esto finalmente genera una insustentabilidad de los servicios ecológicos vitales para nuestra sociedad.

  7. Reflexões sobre o paradigma da economia ecológica para a gestão ambiental

    Directory of Open Access Journals (Sweden)

    Maurício Fuks

    2012-01-01

    Full Text Available Este estudo ressalta a ausência de conhecimento sobre a economia ecológica por parte do crescente número de profissionais formados em Gestão Ambiental. O autor realiza uma síntese dos princípios e fundamentos da economia ecológica, especialmente por meio das ideias de dois dos seus principais pensadores (Georgescu-Röegen e Boulding e indica porque conhecer as ideias principais dessa escola de pensamento é fundamental para profissionais de Gestão Ambiental. Argumenta-se que esses profissionais não podem prescindir da economia ecológica, sob pena de caírem na ilusão do mito da hipótese win-win e terem uma visão incompleta das dificuldades de estabelecermos uma sociedade sustentável.his study draws attention to lack of knowledge regarding Ecological Economics amongst the growing number of professionals graduating in the field of Environmental Management. The author offers a synthesis of the main principles of Ecological Economics, with particular focus on two of its main thinkers (N. Georgescu-Röegen e K. E. Boulding and indicates why such knowledge is of fundamental importance for Environmental Management. The paper argues that environmental managers cannot ignore Ecological Economics; else they may fall prey to the myth of the win-win hypothesis and thus have an incomplete perception of the difficulties involved in establishing a sustainable society.

  8. Myrtaceae na Bacia do Rio Caveiras: Características Ecológicas e Usos Não Madeireiros

    Directory of Open Access Journals (Sweden)

    Juliano Pereira Gomes

    Full Text Available RESUMO Objetivou-se descrever o padrão florístico-estrutural, as características ecológicas e os potenciais das Myrtaceae na bacia hidrográfica do Rio Caveiras. As comunidades de Myrtaceae estudadas localizam-se no Planalto Sul Catarinense, Lages, São José do Cerrito e Urupema. Foram instaladas quatro blocos por município, totalizando 30 mil m2 de área amostral, nos quais todos os espécimes de Myrtaceae com diâmetro à altura do peito (DAP ≥ 5 cm foram amostrados. A estrutura da comunidade de Myrtaceae foi avaliada pelos descritores fitossociológicos e a suficiência amostral foi verificada utilizando-se o método de rarefação. As abordagens ecológicas e indicações de uso não madeireiro basearam-se em bibliografia especializada e base de dados científicos. Foram amostrados 1.480 exemplares de Myrtaceae pertencentes a 21 espécies e 11 gêneros. As espécies mais abundantes foram Myrceugenia euosma, Siphoneugena reitzii e Myrcia palustris, as quais representaram mais de 50% da estrutura da comunidade. Quanto à classificação ecológica, destacou-se o grupo das secundárias iniciais (57%. As espécies amostradas são indicadas para restauração de áreas alteradas, usos ornamentais (100% e fitoterápicos (60%. Apesar da representatividade e potencialidades das Myrtaceae, ainda são necessárias pesquisas para embasar a conservação via plano de manejo.

  9. Bioma cerrado, fragmentação florestal e relações ecológicas com a avifauna

    Directory of Open Access Journals (Sweden)

    Bruno Senna Corrêa

    2010-12-01

    Full Text Available O Bioma Cerrado ocupa grande parte do Brasil central. Destaca-se por apresentar formações savânicas e grande diversidade de aves. O presente trabalho teve por objetivo levantar informações teóricas sobre alguns aspectos ecológicos envolvendo a fragmentação no Bioma Cerrado associada à distribuição de aves. O processo de fragmentação observado nas formações florestais do Cerrado gerou uma série de distúrbios que afetou a distribuição, estabelecimento e comportamento das aves silvestres. A fragmentação influencia diretamente na distribuição dos diversos grupos de aves. Os grupos generalistas, conseguem se deslocar pela matriz antropizada. Já os grupos dependentes de ambientes florestais, dependem de atributos mais complexos de recursos alimentares e condições especiais, para que seu deslocamento seja viabilizado. Por outro lado, a configuração da paisagem, sua estrutura espacial e os graus de conectividade, podem servir como estratégias para propiciar o deslocamento de alguns grupos, dispersores de sementes. Observa-se dessa forma a importância e relevância da presença de corredores ecológicos na conexão de fragmentos, como estratégias essenciais para manutenção do fluxo gênico, da dinâmica ecológica e da manutenção de remanescentes florestais.

  10. Les touristes dans le système touristique polynésien: essai de typologie

    Directory of Open Access Journals (Sweden)

    Caroline Blondy

    2012-03-01

    Full Text Available Les touristes sont couramment considérés, dans la plupart des analyses, comme une catégorie homogène et distincte de la catégorie «société locale». L’un des enjeux de la thèse a été de déconstruire cette idée. Partant d’une définition du tourisme comme «système d’acteurs, de pratiques et de lieux qui a pour objectif de permettre aux individus de se déplacer pour leur recréation hors de leur lieu de vie habituel, en allant habiter temporairement d’autres lieux.» (Dehoorne et al., 2003, l’analyse de la catégorie des touristes amène à s’interroger sur leurs pratiques et leur rapport à l’altérité.

  11. Archivage électronique : spécifications relatives à la conception et à l'exploitation de systèmes informatiques en vue d'assurer la conservation et l'intégrité des documents stockés dans ces systèmes

    CERN Document Server

    Association Française de Normalisation. Paris

    2007-01-01

    Archivage électronique : spécifications relatives à la conception et à l'exploitation de systèmes informatiques en vue d'assurer la conservation et l'intégrité des documents stockés dans ces systèmes

  12. Nueva especie del genero Buenoa Kirkaldy (Hemiptera, notonectidae con clave para especies y notas ecológicas

    Directory of Open Access Journals (Sweden)

    Padilla Gil Dora N.

    1992-06-01

    Full Text Available Se incluyen las especies del género Buenoa encontradas en el Departamento de Cundinamarca con un rango altitudinal entre
    los 1728 y 3000 m.s.n.m. y descipción de la especie Buenoa cucunubensis n. sp., además clave para determinar especies y algunos datos ecológicos.Four species of genus Buenoa are recorded from Cundinamarca province in Colombia, Buenos cucunubensis nov. spec. is
    described. Also included are key to males, data on distribution and ecological information.

  13. Estudio Ecológico de Cambios en el Paisaje del Parque Regional de la Cuenca Alta del Manzanares (Madrid)

    OpenAIRE

    Escribano López, Álvaro

    2010-01-01

    El presente estudio se encuentra enmarcado dentro de la denominada Ecología del Paisaje, la cual se diferencia de la ecología tradicional por tener en consideración al patrón espacial (Turner y Gardner, 1990; Allen y Hoekstra, 1992). Como su propio nombre indica, la Ecología del Paisaje estudia al propio Paisaje, entendido éste como un conjunto de ecosistemas que interaccionan entre sí. Con mayor precisión, el Paisaje es un nivel de organización de los sistemas ecológicos superior al ecosiste...

  14. Integración del turismo educativo en la formación de nuevas sociedades ecológicas

    OpenAIRE

    Hidalgo Arias, Karol; Sandí Delgado, Juan Carlos; Cruz Sancho, Steven

    2014-01-01

    Este artículo es producto de una investigación realizada a nivel de primaria y secundaria en centros educativos ubicados en los cantones de Pococí y Guácimo, Limón, Costa Rica. Donde el principal objetivo fue alcanzar una integración valida entre el turismo educativo y la formación de nuevas sociedades ecológicas. Con el fin de responder a los objetivos de este estudio, dicho trabajo se llevó a cabo mediante el diseño descriptivo y exploratorio, respondiendo a su vez al enfoque metodológi...

  15. Proyecto de una industria de sidra natural ecológica en la localidad de Aguilar de Campoo (Palencia)

    OpenAIRE

    Aparicio Corada, Tamara

    2016-01-01

    Proyecto basado en el diseño e implantación de una industria destinada a la elaboración de sidra natural ecológica situada en el polígono II de la localidad de Aguilar de Campoo (Palencia) . Por las características de situación y comunicación de la zona se pretende ampliar el mercado en este sector y fomentar el desarrollo industrial en ella de una forma eficiente. Se trata de una pequeña industria con una producción alrededor de 10.000 botellas viéndose incrementada durante la vida ...

  16. Función ecológica de la Agricultura Familiar (AF) en la legislación argentina

    OpenAIRE

    Victoria, María Adriana

    2017-01-01

    Construir una nueva ruralidad en la región pasa por fortalecer la Agricultura Familiar (AF) y, a tales fines, los países están desarrollando políticas públicas y programas para estimular este sector fundamental del agro. Por ello, resulta necesario, analizar la función ecológica que cumple la AF en el contenido de la legislación, de aplicación en las provincias argentinas, a partir del marco doctrinario de la Multifuncionalidad de la agricultura (MFA) o Nueva ruralidad (NR) de la AF, a la luz...

  17. CH4 IPDA Lidar mission data simulator and processor for MERLIN: prototype development at LMD/CNRS/Ecole Polytechnique

    Directory of Open Access Journals (Sweden)

    Olivier Chomette

    2018-01-01

    Full Text Available The MEthane Remote sensing Lidar missioN (MERLIN, currently in phase C, is a joint cooperation between France and Germany on the development of a spatial Integrated Path Differential Absorption (IPDA LIDAR (LIght Detecting And Ranging to conduct global observations of atmospheric methane. This presentation will focus on the status of a LIDAR mission data simulator and processor developed at LMD (Laboratoire de Météorologie Dynamique, Ecole Polytechnique, France, for MERLIN to assess the performances in realistic observational situations.

  18. Anurans of the Reserva Ecológica da Michelin, Municipality of Igrapiúna, State of Bahia, Brazil

    OpenAIRE

    Camurugi, Felipe; Lima, Tasso Meneses; Mercês, Ednei de Almeida; Juncá, Flora Acuña

    2010-01-01

    We studied the richness and distribution of anuran species on different breeding sites at the Reserva Ecológica da Michelin (13° 50' S and 39° 10' W, approximately 90-400 m above sea level), Municipality of Igrapiúna, Bahia State, Brazil. The reserve includes fragments of Atlantic Rain Forest varying from 140 to 650 ha. Five types of environments were sampled: leaf litter inside forest fragments, streams inside forest fragments, dam on the edge of forest fragment, temporary pond inside forest...

  19. Caudal ecológico del río Chambas en la provincia Ciego de Ávila

    OpenAIRE

    Brown Manrique, Oscar; Gallardo Ballat, Yurisbel; Williams Harriote, Patricio W.; Torres Martínez, Yuneisi

    2016-01-01

    La investigación se desarrolló en el río Chambas de la provincia Ciego de Ávila con el objetivo de determinar el caudal ecológico mediante cinco metodologías: Curva de Permanencia de Caudales, Rafael Heras, Tennant, Franquet y Perímetro Mojado. Se analizó una serie de 21 años de gastos medios mensuales en el periodo comprendido de 1976 al 1986, obtenidos de la estación hidrométrica Puente Circuito Norte. Los principales resultados demostraron que los caudales promedios del río Chambas present...

  20. Etude systématique et écologique de la faune associée aux moules ()

    OpenAIRE

    Fezzani, S.; Zghal, F.; Ben Amor, Z.; El Abed, A.

    2001-01-01

    Ce travail s’intéresse non seulement à la connaissance de la faune associée aux moules notamment : Mytilus galloprovincialis, mais aussi à une étude systématique et écologique de la faune récoltée. Cette étude a été réalisée dans le lac de Bizerte, à la station de mytiliculture de Menzel Jemil. Une partie de ce travail est consacrée à un examen systématique de la faune récoltée et qui nous a permis d’inventorier 6 embranchements dont les annélides qui sont représentés par 10 espèces de Po...

  1. CDMA à séquence directe appliqué aux systèmes de communications optiques

    OpenAIRE

    Lourdiane , Mounia

    2005-01-01

    Depuis quelques années, le besoin de systèmes de communications plus rapides et plus sures se fait sentir. Le partage entre utilisateurs de la très grande bande passante des fibres optiques nécessite des techniques d'accès adaptées. Afin de répondre à ces besoins, un certain nombre de techniques de multiplexage, dont le CDMA, ont été développées. Cette technique d'accès multiple est déjà largement utilisée dans les systèmes de communications radio-mobiles, que ce soit dans les normes américai...

  2. Observaciones ecológicas en la Isla de Salamanca (Depto. del Magdalena, Colombia Observaciones ecológicas en la Isla de Salamanca (Depto. del Magdalena, Colombia

    Directory of Open Access Journals (Sweden)

    Schnetter Marie-Luise

    1969-06-01

    Grundwasser nicht bis an die Oberfläche steigt. Die oberen Bodenschichten sind dann salzarm, haben aber auch in der Regenzeit nur einen geringen Wassergehalt. An der untersuchten Stelle war der Boden in Grundwassernähe nicht mehr durchwurzelt.  Die meisten der im Trockenbusch wachsenden Arten werfen im Laufe der Trockenzeit ihre Blätter ab. Der Wassergehalt von Arten mit derben Blättern wie Prosopis juliflora und Pithecellobium spec. liegt etwas unter 70% und schwankt nur geringfügig. Pereskia colombiana, die sukkulente Blätter mit einem Wassergehalt von etwa 90% hat, verliert ihre Blätter schon am Ende der Regenzeit. Die Halophyten Batis und Sesuvium haben sukkulente, immergrüne Blätter. Bei beiden Arten ist der Wassergehalt der Blätter in der Regenzeit höher als in der Trockenzeit. Der Wassergehalt der derben immergrünen Blätter von Laguncularia racemosa, einer Mangrovenpflanze, zeigt keine von der Jahreszeit abhängigen Schwankungen.  Es wurde das Längenwachstum von Batis maritima, die in einer feuchten Zone wuchsen, mit dem von Pflanzen eines trockenen Standorts verglichen.  In der Trockenzeit war das Wachstum an beiden Stellen beeinträchtigt, jedoch an dem trockenen Standort stärker als an dem feuchten.  An einer Stelle, an der zwei Jahre zuvor Ableger von Lemaireocereus griseus gepflanzt worden waren, die inzwischen untersehiedlich gut wuchsen, wurde der Salzgehalt des Bodens bestimmt. Er war an Orten, an denen die Kakteen besonders gut gediehen waren, nicht eindeutig niedriger als an anderen Stellen, an denen das Wachstum schlechter gewesen war.  Neben dem Salzgehalt spielt wahrscheinlich die Bodenstruktur eine wichtige Rolle für die Vegetationsentwicklung in diesem Gebiet. Desde agosto de 1965 hasta junio de 1967 se realizaron estudios ecológicos en la Isla de Salamanca. La región mencionada esta situada en la Costa Atlántica de Colombia, entre las ciudades de Ciénaga y Barranquilla, y es limitada por el Mar Caribe en el norte y la Ci

  3. Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. III. rev 3 mutant strains

    International Nuclear Information System (INIS)

    Lawrence, C.W.; Crhistensen, R.B.

    1979-01-01

    The role of rev3 gene function in uv-induced mutagenesis in the yeast Saccharomyces cerevisiae has been examined by determining the reversion of 12 well-defined cyc1 mutations in diploid strains homozygous for the rev3-1 or rev3-3 allale. The 12 cyc1 alleles include one ochre, one amber, four initiation, two proline missense, and four frameshift mutations. We find that the rev3 mutations reduce the frequency of UV-induced reversion of all of the cyc1 alleles, though different classes of alleles respond to a different extent. These results imply that the rev3 gene function is required for the production of a wide variety of mutational events, though probably not all, and show that each of the three rev loci have different mutational phenotypes. Such diverse phenotypes are not predicted by the unitary model for bacterial mutagenes, suggesting that this is at best an incomplete description of eukaryotic mutagenesis

  4. Innocuity and immune response to Brucella melitensis Rev.1 vaccine in camels (Camelus dromedarius

    Directory of Open Access Journals (Sweden)

    A. Benkirane

    2014-10-01

    Full Text Available A field trial was conducted in a camel brucellosis-free herd to evaluate antibody response to the Brucella melitensis Rev.1 vaccine in camels and assess shedding of the vaccine strain in milk. Twenty eight camels were divided into four groups according to their age and vaccination route. Groups A (n=3 and B (n=3 consisted of non-pregnant lactating female camels, vaccinated through subcutaneous and conjunctival routes, respectively. Groups C (n=10 consisted of 8-11 months old calves vaccinated through conjunctival route. The rest of the herd (n=12 composed of female and young camels were not vaccinated and were considered as the control group. Each animal from groups A, B and C was given the recommended dose of 2 x 109 colony forming units of Rev.1 vaccine irrespective of age or route of vaccination. Blood samples were collected from all the animals at the time of vaccination and at weekly, bi-weekly and monthly interval until 32 weeks post vaccination and from controls at weeks 8 and 24. The serological tests used were modified Rose Bengal Test, sero-agglutination test, and an indirect Enzyme Linked Immunosorbent Assay. Milk samples were collected from all vaccinated female camels and tested for the presence of Rev.1 vaccine strain. Most vaccinated animals started to show an antibody response at week 2 and remained positive until week 16. By week 20 post-vaccination all animals in the three groups were tested negative for Brucella antibodies. Bacteriological analysis of milk samples did not allow any isolation of Brucella melitensis. All samples were found Brucella negative in PCR analysis. The results of this study indicate that the Rev.1 vaccine induces seroconversion in camels. Rev.1 vaccine strain is not excreted in the milk of camels. These findings are promising as to the safe use of the Rev.1 vaccine in camels.

  5. Droits des femmes et accès à l'eau et aux systèmes d ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Partout sur la planète, les citadines pauvres doivent composer chaque jour avec les problèmes liés à l'absence de systèmes d'assainissement sûrs, abordables, accessibles et appropriées. L'ONG Women in Cities International (WICI) tente de trouver des moyens de remédier à cette situation en Inde. Cette subvention lui ...

  6. La recherche-action participative appliquée aux systèmes de santé ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    4 déc. 2014 ... Une nouvelle publication, intitulée Participatory Action Research in Health Systems: a methods reader, a été lancée à l'occasion du troisième Symposium mondial sur la recherche sur les systèmes de santé, qui s'est tenu au Cap, en Afrique du Sud, du 30 septembre au 3 octobre 2014. Ce guide des ...

  7. Solutionner les problèmes du système d'autobus urbain au Salvador ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Un trajet en autobus public au Salvador peut être une expérience périlleuse, mais un projet de recherche contribue à améliorer ce système de transport qui dessert des millions de gens. Cet article fait partie d'une série de reportages sur des projets innovants mis en œuvre dans les pays en développement, compilée dans ...

  8. Caractérisation physico-chimique d'un système lotique en région ...

    African Journals Online (AJOL)

    SARAH

    31 mai 2017 ... région tropicale : la rivière Sô au Sud-Bénin, Afrique de l'Ouest. ... la mise en place d'un plan de gestion durable de la rivière et son bassin ...... système qui contrôle et traite les eaux usées avant leur ... Étude dynamique des.

  9. Agent des systèmes d'information financière (h/f) | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Répondre directement aux demandes des utilisateurs formulées par courriel ou par téléphone ou par l'entremise du système de gestion des appels de dépannage. Communiquer au besoin avec les fournisseurs de logiciels et le personnel responsable des TI pour régler les problèmes rencontrés par les utilisateurs finaux ...

  10. Carsim : un système pour convertir des textes en scènes tridimensionnelles animées

    NARCIS (Netherlands)

    Nugues, P.; Dupuy, S.; Egges, A.

    2004-01-01

    Cet article décrit un système de conversion de textes en scènes tridimensionnelles animées. Les textes sont des constats d’accidents de voitures rédigés par un des conducteurs. Le processus de conversion comporte de deux étapes. Un premier module d’extraction d’informations crée une description

  11. Renforcement des capacités de réaliser des examens systématiques

    International Development Research Centre (IDRC) Digital Library (Canada)

    LIRNEasia appliquera les protocoles de la Collaboration Campbell et renforcera les capacités des deux communautés précitées de réaliser des examens systémiques qui évalueront et consolideront les connaissances sur de grandes questions de développement, dont les suivantes : - l'incidence de l'argent mobile sur les ...

  12. Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia.

    Science.gov (United States)

    Tamura, Satoru; Kaneko, Masafumi; Shiomi, Atsushi; Yang, Guang-Ming; Yamaura, Toshiaki; Murakami, Nobutoshi

    2010-03-15

    Bioassay-guided separation from the MeOH extract of the South American medicinal plant Sida cordifolia resulted in isolation of (10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (1) as an unprecedented NES non-antagonistic inhibitor for nuclear export of Rev. This mechanism of action was established by competitive experiment by the biotinylated probe derived from leptomycin B, the known NES antagonistic inhibitor. Additionally, structure-activity relationship analysis by use of the synthesized analogs clarified cooperation of several functionalities in the Rev-export inhibitory activity of 1. Copyright 2010 Elsevier Ltd. All rights reserved.

  13. Administrative Circular No. 22B (Rev. 2) - Compensation for hours of long-term shift work

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 22B (Rev. 2) entitled "Compensation for hours of long-term shift work",  approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208538.   This revised circular cancels and replaces Administrative Circular No. 22B (Rev. 1) also entitled "Compensation for hours of long-term shift work" of March 2011. This document contains minor changes to reflect the new career structure. This circular will enter into force on 1st September 2016.

  14. Administrative Circular No. 13 (Rev. 4) - Guarantees for representatives of the personnel

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 13 (Rev. 4) entitled "Guarantees for representatives of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208527.   This revised circular cancels and replaces Administrative Circular No. 13 (Rev. 3) also entitled "Guarantees for representatives of the personnel" of January 2014. This document contains a single change to reflect the terminology under the new career structure: the term "career path" is replaced by "grade". This circular will enter into force on 1st September 2016.

  15. Empirical investigation of wind farm blockage effects in Horn Rev 1 offshore wind farm

    DEFF Research Database (Denmark)

    Mitraszewski, Karol; Hansen, Kurt Schaldemose; Nygaard, Nicolai

    We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds and stabi......We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds...

  16. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P. [NERI, Dept. of Wildlife Ecology and Biodiversity, Roskilde (Denmark)

    2005-07-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  17. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Hounisen, J.P.

    2005-01-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  18. RevTrans: multiple alignment of coding DNA from aligned amino acid sequences

    DEFF Research Database (Denmark)

    Wernersson, Rasmus; Pedersen, Anders Gorm

    2003-01-01

    The simple fact that proteins are built from 20 amino acids while DNA only contains four different bases, means that the 'signal-to-noise ratio' in protein sequence alignments is much better than in alignments of DNA. Besides this information-theoretical advantage, protein alignments also benefit...... proteins. It is therefore preferable to align coding DNA at the amino acid level and it is for this purpose we have constructed the program RevTrans. RevTrans constructs a multiple DNA alignment by: (i) translating the DNA; (ii) aligning the resulting peptide sequences; and (iii) building a multiple DNA...

  19. Administrative Circular No. 11 (Rev. 4) - Categories of members of the personnel

    CERN Multimedia

    HR Department

    2016-01-01

    Administrative Circular No. 11 (Rev. 4) entitled "Categories of members of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 29 April 2016, will be available on 1 August 2016 via this following link.    This revised circular cancels and replaces the Administrative Circular No. 11 (Rev. 3) also entitled "Categories of members of the personnel" of September 2014. The main changes concern the status of apprentices and their transfer from the category of employed members of personnel to associated members of personnel. This circular will enter into force on 1 August 2016. Department Head Office

  20. Bezpečnost operačního systému Apple iOS

    OpenAIRE

    Zahradníček, Zdeněk

    2013-01-01

    Bakalářská práce se zabývá zabezpečením operačního systému iOS a vytvářením aplikací pro tento systém. Popisuje základní vlastnosti systému, použitá zabezpečení, šifrování a třídy pro bezpečné ukládání souborů. Další oblastí, kterou se práce zabývá je zabezpečení přístupu k internetu a ochranou odesílaných a přijímaných dat. V práci je popsán programovací balíček Xcode, používaný vývojáři pro iOS platformu. Dále byla zkompilována aplikace pro ukázku práce s tímto programovacím balíčkem a její...

  1. Guide du calcul en mécanique valider le comportement des systèmes techniques

    CERN Document Server

    Spenlé, Daniel

    2012-01-01

    Ce guide couvre l’essentiel des programmes de la Première STI2D aux sections de BTS pour les compétences liées à la mécanique. Pour prendre en compte les nouveautés pédagogiques, cette nouvelle édition évolue vers des systèmes « grand public » (robotique humanoïde, cycle trainer, power-ball…) ou des systèmes liés au développement durable(éolienne, scooter électrique…). Points forts - Un guide qui tient compte des orientations du nouveau programme de STI2D : - systèmes vibratoires ; - accéléromètres, effet gyroscopique ; - développement de l’énergétique. - Les disciplines Génie mécanique/Génie électrique sont décloisonnées: - introduction de dispositifs pluri-techniques ; - présentation d’interfaces liant la partie opérative à la partie commande ; - introduction de la conversion de l’énergie électrique en énergie mécanique et réciproquement, étude comportementale, point de fonctionnement, définition des grandeurs associées. - Le caractère expérimental, ...

  2. Systémová dynamika a její modely jako součást Competitive Intelligence

    Directory of Open Access Journals (Sweden)

    Stanislava Mildeová

    2014-12-01

    Full Text Available Obchodní konkurence je oblast, která zatím plně nevyužívá výhod modelování a simulace. V reakci na tento fakt je cílem článku ukázat model simulující konkurenční boj. Model, vycházející z logiky Systémové dynamiky, slouží ke zkoumání efektu vývoje produktů na konkurenceschopnost podniku. V rámci tvorby tohoto vlastního modelu a provedených experimentů autor dokazuje, že použití modelování a simulací je užitečné při získávání nových informací, které nejsou obsaženy v podnikových informačních systémech. I když je prezentovaný model zjednodušením skutečného trhu, takový systémový model může být perspektivním nástrojem Competitive Intelligence.

  3. Ambiente ecológico e mundo vivido: aproximações possíveis entre a fenomenologia de Merleau-Ponty e a Filosofia Ecológica

    Directory of Open Access Journals (Sweden)

    Sabrina Balthazar Ramos Ferreira

    2017-05-01

    Full Text Available O problema mente-corpo esteve na base das discussões filosóficas ao longo de grande parte da história do pensamento ocidental. Com relação à Filosofia da Mente, inúmeros foram os trabalhos que divergiram quanto à separação ou não entre a mente e o corpo, a constituição de ambos ou mesmo a existência do primeiro. Nesse trabalho, abordaremos a posição de Maurice Merleau-Ponty quanto ao dualismo em sua obra A Fenomenologia da Percepção, sua saída para superá-lo e a intrínseca relação do homem com o mundo. Quanto a este último aspecto, buscaremos estabelecer um diálogo com a ideia de ambiente ecológico, abordada pela Filosofia Ecológica, apontando os fatores em comum entre os dois pensamentos filosóficos.

  4. Principios ecológicos en la gestión de los agrosistemas

    Directory of Open Access Journals (Sweden)

    García-Álvarez, A.

    2008-02-01

    Full Text Available Agroecology has as an objective the understanding of the key elements and processes that regulate the function of agrosystems, for their effective management in harmony with the environment. Plant protection has been focused on the concept of control, mainly utilizing chemical or biological arsenals, and more recently, the biotechnological. The application of ecological criteria in plant protection has allowed the implementation of the biofumigation processes, a technique based on the utilization of gases produced during the biodescomposition of organic matter to manage soilborne phytopathogenic organisms. It is hoped that future improvements in agriculture will consider the increasing worries related to the environment, the conservation of the natural resources, public health, and highlighting attention of the importance of agriculture in the elimination of poverty, as well as its contribution to the development of biofuels.La agroecología tiene como objetivo el conocimiento de los elementos y procesos claves en el funcionamiento de los agrosistemas, para su eficaz gestión en armonía con el ambiente. La protección vegetal ha sido enfocada tradicionalmente, bajo el concepto de lucha y control, utilizando arsenales químicos o biológicos y, en estos momentos, biotecnológicos. La aplicación de criterios ecológicos en protección vegetal ha permitido desarrollar procesos como la biofumigación, fundamentada en la utilización de los gases resultantes de la biodescomposición de la materia orgánica para el manejo de organismos patógenos de los vegetales. Es de esperar que el futuro de la agricultura muestre una mayor preocupación por el ambiente, la conservación de los recursos naturales, la salud de las personas y se destaque su contribución a la reducción de la pobreza, así como su aportación al desarrollo de los agrocombustibles.

  5. Gestión integral del agua desde un enfoque social hacia una economía ecológica

    Directory of Open Access Journals (Sweden)

    María de los Ángeles Gil Antonio

    2015-01-01

    Full Text Available El modelo de economía ecológica es un sistema abierto que distingue las interrelaciones entre el sistema económico y el ecológico. En ese sentido, es integral, pues considera aspectos moneta - rios, sociales y ambientales. En lo que respecta al estudio de la disminución en la disponibilidad de agua, este modelo presenta una alternativa, pues daría cuenta de aquellos aspectos relaciona - dos con la gestión integral del agua que apunta a la participación de la sociedad como una opción alterna. El objetivo de este trabajo es mostrar la relación entre la economía ecológica y la gestión integral del agua, tomando en consideración que para ambas el aspecto social es significativo.

  6. O psicólogo ecológico no contexto institucional: uma experiência com meninas vítimas de violência

    Directory of Open Access Journals (Sweden)

    Clarissa De Antoni

    Full Text Available Este ensaio consiste em um relato da experiência de trabalho de um psicólogo ecológico em uma instituição para meninas vítimas de violência, embasada no Modelo Ecológico de Desenvolvimento Humano. É discutida a integração da prática com a teoria, envolvendo desde aspectos relacionados ao cotidiano da instituição e da história de vida das meninas, até a influência cultural e social dos sistemas ecológicos. Os resultados mostraram que a integração destes aspectos levaram à melhoria da qualidade do trabalho dos profissionais e da vida das meninas atendidas.

  7. Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

    Directory of Open Access Journals (Sweden)

    Hong Zan

    2012-11-01

    Full Text Available By diversifying the biological effector functions of antibodies, class switch DNA recombination (CSR plays a critical role in the maturation of the immune response. It is initiated by activation-induced cytidine deaminase (AID-mediated deoxycytosine deamination, yielding deoxyuridine (dU, and dU glycosylation by uracil DNA glycosylase (Ung in antibody switch (S region DNA. Here we showed that the translesion DNA synthesis polymerase Rev1 directly interacted with Ung and targeted in an AID-dependent and Ung-independent fashion the S regions undergoing CSR. Rev1−/− Ung+/+ B cells reduced Ung recruitment to S regions, DNA-dU glycosylation, and CSR. Together with an S region spectrum of mutations similar to that of Rev1+/+ Ung−/− B cells, this suggests that Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1−/− Msh2−/− B cells. Rescue of CSR in Rev1−/− B cells by a catalytically inactive Rev1 mutant shows that the important role of Rev1 in CSR is mediated by Rev1’s scaffolding function, not its enzymatic function.

  8. 39 VetoMed : un système expert à base d'icônes pour la médecine ...

    African Journals Online (AJOL)

    PR BOKO

    Mots-clés: système expert, générateur de systèmes expert, base de connaissances, médecine traditionnelle vétérinaire, plantes médicinales, interface iconique, tradipraticien. Abstract. VetoMed : An icon-based expert system for Traditional Veterinary Medicine. In this paper we propose an expert system in which, icons are ...

  9. Los Desplazamientos en el Discurso ´Ecológico´: del Naturalismo Social al Sociologismo Natural

    Directory of Open Access Journals (Sweden)

    Rosario Rogel Salazar

    2000-01-01

    Full Text Available Este ensayo ofrece una introducción al desarrollo sustentable que permita, en la medida de lo posible, fomentar una actitud crítica ante la manera en que se analiza hoy la cuestión de la sustentabilidad. El hilo conductor es la búsqueda del sistema conceptual, que ha concebido los problemas ecológicos como “perturbaciones” y que ahora arriba a una postura denominada “desarrollo sustentable”, como nueva construcción utópica del proyecto de la modernidad. Se busca enmarcar el problema como una cuestión epistémica, debido a que ha sido la forma de razonar/conocer lo que ha circunscrito las catástrofes ecológicas a ‘perturbaciones’; es decir, a situaciones a controlar, lo que da pie a la idea de desarrollo sustentable. En síntesis, estas líneas proponen enfrentar el problema de la intervención e interpretación del sujeto en la construcción de proyectos colectivos, en los que se ha ubicado al desarrollo sustentable.

  10. Factores que determinan la resiliencia socio-ecológica para la alta montaña andina

    Directory of Open Access Journals (Sweden)

    Samir Joaqui Daza

    2014-12-01

    Full Text Available El presente artículo de revisión está enmarcado en el desarrollo de una tesis doctoral en Ciencias Ambientales. Analiza los procesos tradicionales de gestión y planificación que han tenido un enfoque disciplinar para enfrentar problemáticas ambientales como el cambio climático en la alta montaña andina cuyo propósito se ha centrado en el manejo o mitigación de los impactos ambientales generados por las actividades antrópicas. Sin embargo, el deterioro ecológico aumenta debido a que las bases conceptuales en las que se fundamentan las herramientas de gestión por lo general son descontextualizadas, asumiendo que las relaciones socio ecológicas se pueden desagregar para ser estudiadas y que los fenómenos de la naturaleza son predecibles y controlables. Considerando lo anterior, se propone la incorporación de teorías complementarias como los socio-ecosistemas, la resiliencia, la transformabilidad, la adaptación y la vulnerabilidad.

  11. ¿Conocimiento, medio ambiente o salud? Una investigación sobre los determinantes del consumo de alimentos ecológicos en España

    OpenAIRE

    López Galán, Belinda Susan; Gracia Royo, Azucena; Barreiro Hurlé, Jesús

    2013-01-01

    El objetivo de este estudio es determinar los factores que influyen en la intención de compra de alimentos ecológicos de los consumidores españoles. Para ello se ha especificado un modelo de intención de compra basado en la Teoría del Comportamiento Planeado de Ajzen al que se ha añadido el nivel de conocimiento sobre los alimentos ecológicos y la preocupación por la salud y el medioambiente como factores determinantes de la intención de compra. Para estimar el modelo se ha especificado un mo...

  12. ALUMNO: VARGAS DIEGO, Estimación de la huella ecológica del minifundio en la vereda Pasquilla, Bogotá, Colombia

    OpenAIRE

    VALERO VARGAS, RAFAEL ERNESTO; BELTRÁN VARGAS, JULIO EDUARDO

    2016-01-01

    En la actualidad el país no cuenta con un instrumento de gestión ambiental que permita estimar la huella ecológica provocada por las actividades agropecuarias de los minifundios, lo que restringe la formulación de políticas públicas locales de desarrollo agropecuario. En 2014, se midió la huella ecológica de 27 minifundios en la vereda Pasquilla de Bogotá, Cundinamarca, Colombia. La información provino de los productores y fue complementada con revisiones secundarias de las pub...

  13. O apelo ecológico na propaganda como fator de influência na atitude de compra do consumidor: um estudo experimental

    OpenAIRE

    Santos, João Maurício

    2010-01-01

    Este estudo examinou o apelo ecológico utilizado na propaganda como influenciador na atitude de compra do consumidor, tendo em vista que nas duas últimas décadas houve um crescimento nos anúncios que utilizam este tipo de apelo, demonstrando que, pelo surgimento de um novo nicho de mercado, empresas têm se valido do marketing verde e da influência normativa na sua estratégia de marketing. Buscou-se investigar se efetivamente o uso do apelo ecológico na propaganda influencia pos...

  14. Análisis de la racionalidad ecológica en agricultores hortícolas de La Plata, Argentina.

    OpenAIRE

    Gargoloff, Natalia Agustina; Abbona, Esteban Andres; Sarandón, Santiago Javier

    2010-01-01

    La existencia de una racionalidad ecológica implícita en el manejo de los recursos naturales em agricultores tradicionales, ha permitido la sustentabilidad de los agroecosistemas. Comprender la racionalidad ecológica en agricultores con características diferentes a la agricultura tradicional, podría contribuir a avanzar hacia una agricultura sustentable. Sin embargo, esto no es sencillo debido a la propia complejidad del término y la ausencia de una metodología que permita abordarla. En este ...

  15. Superando los límites medioambientales de la empresa: Un estudio experimental del efecto del posicionamiento ecológico en la actitud hacia la marca

    OpenAIRE

    Hartmann, Patrick; Forcada Sainz, Francisco Javier; Apaolaza Ibáñez, Vanesa

    2004-01-01

    Ponencia presentada y defendida en el XI Congreso Internacional de la Asociación de Dirección y Economía de la Empresa (AEDEM), celebrado en París en septiembre de 2002. [ES] La reducción del impacto medioambiental de un producto o de su proceso de fabricación no necesariamente constituye una limitación a la actividad empresarial, sino puede, asimismo, representar una oportunidad estratégica en el marco de una gestión de marcas ecológica. El posicionamiento ecológico se presenta como un...

  16. Indicadores ecológicos de hábitat y biodiversidad en un paisaje neotropical: perspectiva multitaxonómica

    Directory of Open Access Journals (Sweden)

    Noel González-Valdivia

    2011-09-01

    Full Text Available El uso de especies indicadoras para caracterizar unidades ecológicas específicas es de gran importancia en la biología de la conservación/restauración. El objetivo del estudio fue identificar desde una perspectiva multitaxonómica, las especies que caracterizan distintas unidades de un paisaje. Así, se diferenciaron dos ecomosaicos: bosque tropical lluvioso y matriz agropecuaria con cuatro unidades de paisaje cada uno. Se incluyeron cuatro grupos biológicos: aves (muy móviles, mariposas frugívoras diurnas (moderadamente móviles, gasterópodos terrestres (poco móviles y árboles (sésiles. La eficiencia de muestreo en los ecomosaicos fue ≥86%. Se registraron 50 especies de moluscos, 74 de mariposas, 218 de aves y 172 de árboles, totalizando 514 especies. Mediante ordenamiento y agrupamiento, se diferenciaron tres tipos de hábitats: bosque tropical lluvioso, vegetación secundaria y potreros con árboles. Aplicando el método InVal (≥50%, se identificaron 107 especies indicadoras, de las cuales 45 fueron árboles, 38 aves, 14 mariposas y diez gasterópodos. De éstas, 35 especies de árboles, diez de aves, cuatro de mariposas y ocho de gasterópodos son indicadoras del bosque. Diez, veintiocho, diez y dos especies (de cada grupo respectivamente caracterizaron a la matriz agropecuaria. En el bosque, los gasterópodos Carychium exiguum, Coelocentrum turris, Glyphyalinia aff. indentata y Helicina oweniana se correlacionaron significativamente (pEcological indicators of habitat and biodiversity in a Neotropical landscape: multitaxonomic perspective. The use of indicator species to characterize specific ecological areas is of high importance in conservation/ restoration biology. The objective of this study was to identify indicator species of diverse taxa that characterize different landscape units, and to better understand how management alters species composition. We identified two ecomosaics, tropical rain forest and the

  17. Estructura y daños en las comunidades de octocorales (Octocorallia: Alcyonacea de la Reserva Ecológica Siboney-Juticí, Santiago de Cuba, Cuba

    Directory of Open Access Journals (Sweden)

    Yunier Olivera Espinosa

    2010-12-01

    Full Text Available Se estudió la comunidad de octocorales del arrecife de macizos y canales de la Reserva Ecológica Siboney- Juticí (sur oriente de Cuba con el objetivo de caracterizar su composición, estructura y estado de conservación, así como inferir a partir de estas las condiciones ambientales imperantes en el área. La investigación se realizó entre enero y junio de 2009, en seis localidades ubicadas entre 12m y 17m de profundidad. Como unidad de muestreo se empleó un marco de 1m², el cual fue puesto en zigzag cada 2m sobre la superficie del arrecife de macizos. Se determinó, por localidad, la densidad de colonias y se infirieron los grados de severidad, constancia ambiental, tensión hidrodinámica y el Índice Comparativo de Contaminación. Se determinaron, además, los daños en la comunidad de octocorales. Se analizaron 752 colonias e identificaron 25 especies de octocorales. Eunicea flexuosa y Gorgonia ventalina fueron las especies más abundantes. La densidad fluctuó entre 3.58±1.84 colonias/m² y 7.58±2.16 colonias/ m² (densidad de baja a moderada tendiendo a baja. En la zona se infirió una tensión hidrodinámica entre baja y alta, con niveles de contaminación bajos y moderados, y un ambiente generalmente favorable y constante. Los daños de tipo mecánico fueron los más frecuentes, siendo G. ventalina la especie con más colonias dañadas. La comunidad de octocorales del hábitat de macizos y canales de la Reserva Ecológica Siboney-Juticí presentó un buen estado de conservación.Structure and injuries of octocoral communities (Octocorallia: Alcyonacea of Ecological Reserve Siboney-Juticí, Santiago de Cuba, Cuba. In the spur-and-groove reefs of the Ecological Reserve Siboney-Juticí (Southeast Cuba octocorals are one of the predominant components of the sessile fauna. Main objectives of the present paper are characterizing the composition, structure and conservation status of the octocoral communities and assessing on the

  18. Metabolism and apoptotic properties of elevated ceramide in HT29(rev) cells

    NARCIS (Netherlands)

    Veldman, R J; Klappe, K; Hoekstra, D; Kok, J W

    1998-01-01

    Ceramide (Cer) has been implicated in the regulation of apoptosis. In this study, we elevated cellular Cer levels in human colon-carcinoma (HT29(rev)) cells by incubating the cells in the presence of bacterial sphingomyelinase (bSMase) or, alternatively, in the presence of C2-Cer, a short-chain

  19. Material Trends ( From M.Imada, A. Fujimori, and Y. Tokura, Rev ...

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Material Trends ( From M.Imada, A. Fujimori, and Y. Tokura, Rev. Mod. Phys. 70, 1039 (1998) ). Differences due to changes in cation radius causing bending of Mn-O-Mn bonds. Extreme sensitivity to small changes.

  20. 48 CFR 53.301-18 - SF 18 (Rev. 6/95), Request for Quotations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 18 (Rev. 6/95), Request for Quotations. 53.301-18 Section 53.301-18 Federal Acquisition Regulations System FEDERAL ACQUISITION... for Quotations. EC01MY91.002 [60 FR 34763, July 3, 1995] ...

  1. Determining the REV for Fracture Rock Mass Based on Seepage Theory

    Directory of Open Access Journals (Sweden)

    Lili Zhang

    2017-01-01

    Full Text Available Seepage problems of the fractured rock mass have always been a heated topic within hydrogeology and engineering geology. The equivalent porous medium model method is the main method in the study of the seepage of the fractured rock mass and its engineering application. The key to the method is to determine a representative elementary volume (REV. The FractureToKarst software, that is, discrete element software, is a main analysis tool in this paper and developed by a number of authors. According to the standard of rock classification established by ISRM, this paper aims to discuss the existence and the size of REV of fractured rock masses with medium tractility and provide a general method to determine the existence of REV. It can be gleaned from the study that the existence condition of fractured rock mass with medium tractility features average fracture spacing smaller than 0.6 m. If average fracture spacing is larger than 0.6 m, there is no existence of REV. The rationality of the model is verified by a case study. The present research provides a method for the simulation of seepage field in fissured rocks.

  2. Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction.

    Science.gov (United States)

    Sail, Vibhavari; Rizzo, Alessandro A; Chatterjee, Nimrat; Dash, Radha C; Ozen, Zuleyha; Walker, Graham C; Korzhnev, Dmitry M; Hadden, M Kyle

    2017-07-21

    Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired resistance so often observed with standard anticancer regimens. As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate. The TLS DNA polymerase Rev1 serves as an integral scaffolding protein that mediates the assembly of the active multiprotein TLS complexes. Protein-protein interactions (PPIs) between the C-terminal domain of Rev1 (Rev1-CT) and the Rev1-interacting region (RIR) of other TLS DNA polymerases play an essential role in regulating TLS activity. To probe whether disrupting the Rev1-CT/RIR PPI is a valid approach for developing a new class of targeted anticancer agents, we designed a fluorescence polarization-based assay that was utilized in a pilot screen for small molecule inhibitors of this PPI. Two small molecule scaffolds that disrupt this interaction were identified, and secondary validation assays confirmed that compound 5 binds to Rev1-CT at the RIR interface. Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.

  3. Molecular typing of Brucella melitensis endemic strains and differentiation from the vaccine strain Rev-1.

    Science.gov (United States)

    Noutsios, Georgios T; Papi, Rigini M; Ekateriniadou, Loukia V; Minas, Anastasios; Kyriakidis, Dimitrios A

    2012-03-01

    In the present study forty-four Greek endemic strains of Br. melitensis and three reference strains were genotyped by Multi locus Variable Number Tandem Repeat (ML-VNTR) analysis based on an eight-base pair tandem repeat sequence that was revealed in eight loci of Br. melitensis genome. The forty-four strains were discriminated from the vaccine strain Rev-1 by Restriction Fragment Length Polymorphism (RFLP) and Denaturant Gradient Gel Electrophoresis (DGGE). The ML-VNTR analysis revealed that endemic, reference and vaccine strains are genetically closely related, while most of the loci tested (1, 2, 4, 5 and 7) are highly polymorphic with Hunter-Gaston Genetic Diversity Index (HGDI) values in the range of 0.939 to 0.775. Analysis of ML-VNTRs loci stability through in vitro passages proved that loci 1 and 5 are non stable. Therefore, vaccine strain can be discriminated from endemic strains by allele's clusters of loci 2, 4, 6 and 7. RFLP and DGGE were also employed to analyse omp2 gene and reveled different patterns among Rev-1 and endemic strains. In RFLP, Rev-1 revealed three fragments (282, 238 and 44 bp), while endemic strains two fragments (238 and 44 bp). As for DGGE, the electrophoretic mobility of Rev-1 is different from the endemic strains due to heterologous binding of DNA chains of omp2a and omp2b gene. Overall, our data show clearly that it is feasible to genotype endemic strains of Br. melitensis and differentiate them from vaccine strain Rev-1 with ML-VNTR, RFLP and DGGE techniques. These tools can be used for conventional investigations in brucellosis outbreaks.

  4. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2004-05-15

    Elsam and Eltra built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm off the Danish west coast. The wind farm is sited 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine was erected in May 2002 and the last wind turbine tower of a total of 80 was in place by August 2002. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production by December 2002. The expected impact of the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind turbine towers and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horns Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site-specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrate was conducted in March 2003 and in September 2003. This report describes the first year results of surveys on hard substrate after the completion of the offshore wind farm at Horns Rev. (au)

  5. Offshore wind farms in the local community - a survey at Horns Rev wind farm. Background report; Havvindmoeller i lokalomraedet - en undersoegelse ved Horns Rev havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, S.

    2005-07-15

    This report is part of a socio-economic project about offshore wind farms' influence on the local community. The project is part of the monitoring programme in connection with the establishment of the offshore wind farms at Horns Rev and Nysted. The socio-economic project consists of a sociological and an environment-economic project. This report is part of the sociological project which has the purpose of identifying attitudes towards the wind farm before and after the erection with a view to identify possible changes in opinions and reasons for these changes. (BA)

  6. Approche systémique du processus de gestion des ressources humaines

    Directory of Open Access Journals (Sweden)

    Cesar Nieto Licht

    2013-08-01

    Full Text Available Rev.esc.adm.neg Mediante la comprensión de la teoría sistémica, su evolución y sus aplicaciones se plantearán los retos generales y específicos que afrontan actualmente los profesionales de Gestión Humana para diseñar y desarrollar sus procesos de manera sistémica, generando valor para la organización y aportando significativamente al desarrollo de la empresa y de los seres humanos que la conforman. Por lo tanto, este artículo presentará una exploración por las herramientas de la era de la máquina, su impacto en el proceso de pensamiento de los administradores, el significado de la era sistémica y sus aplicaciones e incidencias en el diseño de los procesos. Finalmente, se presentarán los retos específicos que los profesionales de Gestión Humana deben afrontar para intervenir sus procesos bajo un enfoque sistémico.

  7. Rapport d’étape – Le Système canadien hospitalier d’information et de recherche en prévention des traumatismes : un système de surveillance des blessures dynamique et novateur

    Directory of Open Access Journals (Sweden)

    J. Crain

    2016-01-01

    Full Text Available Ce rapport d’étape sur le Système canadien hospitalier d’information et de recherche en prévention des traumatismes (SCHIRPT, un système de surveillance des blessures et des empoisonnements utilisé par les services d’urgence, décrit le résultat de la migration d’un processus d’entrée et de codage des données centralisé vers le processus décentralisé de l’eSCHIRPT, réalisée en 2011. Ce système sécurisé accroît la souplesse et la rapidité globales du SCHIRPT, attributs clés d’un système de surveillance efficace. La plate-forme intégrée de l’eSCHIRPT permet une entrée de données et un accès aux données en temps quasi réel, comprend des outils conviviaux de gestion et d’analyse des données et facilite la communication et la connectivité au sein du réseau du SCHIRPT grâce à un centre de collaboration en ligne. L’essai pilote mené actuellement sur les outils automatisés de contrôle de données et d’analyse des tendances – destinés à surveiller et à mettre en évidence les données d’entrée à partir de critères prédéfinis (par exemple un nouveau produit de consommation – révèle le potentiel de détection rapide des nouveaux dangers, enjeux et tendances que possède l’eSCHIRPT.

  8. Valor ambiental em uma perspectiva heterodoxa institucional-ecológica: an institutional-ecological heterodox perspective Environmental value

    Directory of Open Access Journals (Sweden)

    Maurício de Carvalho Amazona

    2009-04-01

    Full Text Available O presente trabalho discute a perspectiva de valoração ambiental a partir de fundamentos heterodoxos, numa abordagem aqui denominada institucional-ecológica. Inicia-se pela identificação das principais limitações da abordagem neoclássica e suas correspondentes proposições de valoração, particularmente tendo-se em vista o desafio posto pelo critério de Desenvolvimento Sustentável. Em seguida, busca resgatar princípios propositivos de abordagens heterodoxas, particularmente nas formulações do campo teórico institucionalista e do campo teórico da economia ecológica, como elementos de potencial integração analítica para a constituição de uma conceituação heterodoxa de valores ambientais. Por fim, o trabalho propõe, a partir de uma discussão sobre o processo de formação e internalização dos valores ambientais e desse potencial de integração analítica, bases de constituição de uma abordagem institucional-ecológica para interpretação da valoração ambiental e, dentro dessa perspectiva, discute ao final qual o escopo de aplicação dos métodos de valoração correntemente utilizados pela Economia Ambiental Neoclássica.This article discusses an environmental valuation perspective, based on heterodox foundations, in an approach here called institutional-ecological. First, it is identified the main limits of neoclassical approach and its corresponding valuation propositions, specially having in mind the challenge placed by Sustainable Development criteria. After, it seeks to bring up propositive principles from heterodox approaches, particularly from formulations in the institutionalist field and ecological economics field. These are considered elements potentially able to analytical integration for the constitution of a heterodox framework for environmental values. Finally, based on a discussion on the process of environmental values constitution and internalization and on the so claimed analytical integration

  9. Système expert pour la conception en électronique de puissance

    Science.gov (United States)

    Fezzani, D.; Piquet, H.; Foch, H.

    1996-03-01

    The study that we propose concerns the automatic design of static converters and especially of Uninterrupted Power Supply (UPS). The aim is the development of a tool bringing an assistance in the analysis of the specifications, the choice and design of the structure that best match the application. To realize the design of these UPS, a new approach is presented. Specifications are described in terms of input and output performances (voltage, current, ...). These data are analyzed by using design rules and methods which allows designing the input filter, the output filter, the inverter, the rectifier, etc. In practice, these rules and methods are implemented on a micro computer by use of an “expert system generator” SMECI. We present and justify the modular structure that has been installed, as well as its functioning. L'étude que nous proposons concerne la conception automatique des convertisseurs statiques et en particulier des Alimentations Sans Interruption (ASI). Le but recherché est la mise au point d'un outil apportant une aide à l'analyse du cahier des charges, au choix et au dimensionnement des structures les mieux adaptées. Pour réaliser la conception de ces ASI, une nouvelle approche est présentée. Les spécifications sont décrites par les performances recherchées au niveau des courants et des tensions à l'entrée et à la sortie. Ces données sont analysées par l'emploi de méthodes et de règles de conception permettant ainsi de dimensionner le filtre d'entrée, le filtre de sortie, l'onduleur, le redresseur, etc. Au plan pratique, ces règles et méthodes sont implantées à l'aide du “générateur de système expert” SMECI. Nous présentons et justifions la structure modulaire qui a été mise en place, ainsi que son fonctionnement.

  10. MicroRNA-340 inhibits the proliferation and promotes the apoptosis of colon cancer cells by modulating REV3L

    Science.gov (United States)

    Arivazhagan, Roshini; Lee, Jaesuk; Bayarsaikhan, Delger; Kwak, Peter; Son, Myeongjoo; Byun, Kyunghee; Salekdeh, Ghasem Hosseini; Lee, Bonghee

    2018-01-01

    DNA Directed Polymerase Zeta Catalytic Subunit (REV3L) has recently emerged as an important oncogene. Although the expressions of REV3L are similar in normal and cancer cells, several mutations in REV3L have been shown to play important roles in cancer. These mutations cause proteins misfolding and mislocalization, which in turn alters their interactions and biological functions. miRNAs play important regulatory roles during the progression and metastasis of several human cancers. This study was undertaken to determine how changes in the location and interactions of REV3L regulate colon cancer progression. REV3L protein mislocalization confirmed from the immunostaining results and the known interactions of REV3L was found to be broken as seen from the PLA assay results. The mislocalized REV3L might interact with new proteins partners in the cytoplasm which in turn may play role in regulating colon cancer progression. hsa-miR-340 (miR-340), a microRNA down-regulated in colon cancer, was used to bind to and downregulate REV3L, and found to control the proliferation and induce the apoptosis of colon cancer cells (HCT-116 and DLD-1) via the MAPK pathway. Furthermore, this down-regulation of REV3L also diminished colon cancer cell migration, and down-regulated MMP-2 and MMP-9. Combined treatment of colon cancer cells with miR-340 and 5-FU enhanced the inhibitory effects of 5-FU. In addition, in vivo experiments conducted on nude mice revealed tumor sizes were smaller in a HCT-116-miR-340 injected group than in a HCT-116-pCMV injected group. Our findings suggest mutations in REV3L causes protein mislocalization to the cytoplasm, breaking its interaction and is believed to form new protein interactions in cytoplasm contributing to colon cancer progression. Accordingly, microRNA-340 appears to be a good candidate for colon cancer therapy. PMID:29435169

  11. Identification of Brucella melitensis Rev.1 vaccine-strain genetic markers: Towards understanding the molecular mechanism behind virulence attenuation.

    Science.gov (United States)

    Issa, Mohammad Nouh; Ashhab, Yaqoub

    2016-09-22

    Brucella melitensis Rev.1 is an avirulent strain that is widely used as a live vaccine to control brucellosis in small ruminants. Although an assembled draft version of Rev.1 genome has been available since 2009, this genome has not been investigated to characterize this important vaccine. In the present work, we used the draft genome of Rev.1 to perform a thorough genomic comparison and sequence analysis to identify and characterize the panel of its unique genetic markers. The draft genome of Rev.1 was compared with genome sequences of 36 different Brucella melitensis strains from the Brucella project of the Broad Institute of MIT and Harvard. The comparative analyses revealed 32 genetic alterations (30 SNPs, 1 single-bp insertion and 1 single-bp deletion) that are exclusively present in the Rev.1 genome. In silico analyses showed that 9 out of the 17 non-synonymous mutations are deleterious. Three ABC transporters are among the disrupted genes that can be linked to virulence attenuation. Out of the 32 mutations, 11 Rev.1 specific markers were selected to test their potential to discriminate Rev.1 using a bi-directional allele-specific PCR assay. Six markers were able to distinguish between Rev.1 and a set of control strains. We succeeded in identifying a panel of 32 genome-specific markers of the B. melitensis Rev.1 vaccine strain. Extensive in silico analysis showed that a considerable number of these mutations could severely affect the function of the associated genes. In addition, some of the discovered markers were able to discriminate Rev.1 strain from a group of control strains using practical PCR tests that can be applied in resource-limited settings. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Estudios ecológicos en salud ambiental: más allá de la epidemiología

    Directory of Open Access Journals (Sweden)

    Luis C. Blanco-Becerra

    2015-08-01

    Full Text Available Los estudios ecológicos se caracterizan por tener como unidad de análisis a las poblaciones, y constituyen una fuente importante y frecuente de información comprobada en salud ambiental. En esta revisión se resumen los fundamentos de los estudios ecológicos, partiendo de la premisa de que es posible hacerlos con métodos cuantitativos, cualitativos o mixtos. Se presenta la lógica que subyace a su diseño, y su papel en la exploración de la causalidad, las variables y las categorías de análisis, los principales diseños y las técnicas de recolección de datos. Igualmente, se dan ejemplos de estudios ecológicos llevados a cabo en América Latina, y se discuten algunos de los problemas metodológicos frecuentes y las posibles vías para abordarlos. Por último, se resalta la relevancia de los estudios ecológicos cuantitativos y cualitativos en salud ambiental como una forma de superar el individualismo conceptual y metodológico hegemónico, que resulta insuficiente para el estudio de la salud en las poblaciones.

  13. Recruitment and Workplace Integration of Men and Women Engineers in France: The Case of EPF Ecole D'ingénieurs Graduates

    Science.gov (United States)

    Stevanovic, Biljana

    2014-01-01

    Based on "First Job" surveys conducted six months after graduation among graduates from 2000 to 2007 and semi-structured interviews, this paper examines the recruitment and workplace integration of women and men graduates from EPF Ecole d'Ingenieurs. The study's findings show that women engineering graduates from EPF generally have more…

  14. How well can blood pressure be controlled? Progress report on the Systolic Hypertension in Europe Follow-Up Study (Syst-Eur 2

    Directory of Open Access Journals (Sweden)

    Sarti Cinzia

    2001-10-01

    Full Text Available Abstract Background The randomised, double-blind, placebo-controlled Systolic Hypertension in Europe trial (Syst-Eur 1 proved that blood pressure (BP lowering therapy starting with nitrendipine reduces the risk of cardiovascular complications in elderly patients with isolated systolic hypertension. In an attempt to confirm the safety of long-term antihypertensive therapy based on a dihydropyridine, the Syst-Eur patients remained in open follow-up after the end of Syst-Eur 1. This paper presents the second progress report of this follow-up study (Syst-Eur 2. It describes BP control and adherence to study medications. Methods After the end of Syst-Eur 1 all patients, treated either actively or with placebo, were invited either to continue or to start antihypertensive treatment with the same drugs as previously used in the active treatment arm. In order to reach the target BP (sitting SBP Results Of the 3787 eligible patients, 3516 (93% entered Syst-Eur 2. At the last available visit, 72% of the patients were taking nitrendipine. SBP/DBP at entry in Syst-Eur 2 averaged 160/83 mmHg in the former placebo group and 151/80 mmHg in the former active-treatment group. At the last follow-up visit SBP/DBP in the patients previously randomised to placebo or active treatment had decreased by 16/5 mmHg and 7/5 mmHg, respectively. The target BP was reached by 74% of the patients. Conclusion Substantial reductions in systolic BP may be achieved in older patients with isolated systolic hypertension with a treatment strategy starting with the dihydropyridine calcium-channel blocker, nitrendipine, with the possible addition of enalapril and/or hydrochlorothiazide.

  15. Systèmes d'innovation des pays BRICS (Brésil, Russie, Inde, Chine ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Brésil, la Russie, l'Inde, la Chine et l'Afrique du Sud (dits pays BRICS) ont placé l'innovation au coeur de leur stratégie de développement. Toutefois, les chercheurs disposent de très peu de connaissances sur le système d'innovation de chacun de ces pays et sur les répercussions qu'il a sur l'économie. La subvention ...

  16. Détection de dysfonctionnement d'un système amortisseur de véhicule automobile

    OpenAIRE

    Ragot , José; Maquin , Didier; Adrot , Olivier; Boatas , Armand; Jampi , Didier

    2003-01-01

    International audience; Le système d'amortissement d'un véhicule est un organe sensible au vieillissement, à l'usure et à des défauts accidentels ; les conséquences de ces perturbations sur la tenue de route peuvent être critiques et l'on conçoit alors l'intérêt de développer des méthodes de diagnostic capables de renseigner sur l'état de fonctionnement de ce dispositif en fournissant des indicateurs d'alerte de dysfonctionnement. Cette communication apporte quelques éléments méthodologiques ...

  17. Modernización ecológica y políticas ambientales: notas para un debate (Brasil).

    OpenAIRE

    Olivier, Alejandro Gabriel; Domínguez, Carlos Federico

    2011-01-01

    El propósito del presente artículo es explorar conceptualmente la teoría de la modernización ecológica. Se trata de demostrar que dicha teoría, inicialmente sustentada por autores tales como Joseph Huber y Marteen Jänicke, y con desarrollos conceptuales más complejos a partir de los trabajos de Arthur Mol y Gert Spaargarem, entre otros, puede conducir a una revisión sustancial en la percepción, en la formulación y en la implementación de las políticas ambientales. El artículo concluye con el ...

  18. Návrhový systém pro zjištění a kvantifikaci požadavků na řídicí systém inteligentního domu

    OpenAIRE

    Kotík, Miloslav

    2015-01-01

    Bakalářská práce se věnuje analýze požadavků investora na řídicí systém inteligentního domu. Je navržen dotazník jako vodítko projektanta při komunikaci s investorem a tento postup je převeden do interaktivní podoby formuláře. Na základě dotazníku je poté navržen postup pro automatické vyhodnocení a převod zjištěných požadavků investora do seznamu doporučených komponent řídicího systému Tecomat Foxtrot a jeho periferií pro realizaci. První dvě kapitoly práce jsou teoretické a popisují intelig...

  19. Administrative Cicular No. 31 (Rev. 2) - International indemnity and non-resident allowance

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 31 (Rev. 2) entitled "International indemnity and non-resident allowance", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 23 June 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208547.   This revised circular cancels and replaces Administrative Circular No. 31 (Rev. 1) also entitled "International indemnity and non-resident allowance" of October 2007. The main changes reflect the decision taken in the framework of the five-yearly review to extend eligibility for international indemnity to all staff members, as well to introduce a distinction between current staff members and those recruited as from 1st September 2016. For the latter, the international indemnity will be calculated as a percentage of the minimum salary of the grade into which they are recruited; the amount granted to the former will not change, and is now expressed ...

  20. Administrative Circular No. 11 (Rev. 3) - Categories of members of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 11 (Rev. 3) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 3 July 2014 and entering into force on 1 September 2014, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel” of January 2013. The circular was revised in order to include a minor adjustment of the determination of required period of break in the payment of subsistence allowance to certain categories of associated members of the personnel (taking account of possible technical means of control). Furthermore, the possibility of traineeships of long duration was restricted to cases in which the traineeship is awarded pursuant to an agreement between CERN and a...

  1. Administrative Circular No. 13 (Rev. 3) - Guarantees for representatives of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 13 (Rev. 3) entitled “Guarantees for representatives of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 13 (Rev. 2) entitled “Guarantees for members of the personnel holding representative office” of November 1992. The circular was revised in order to adapt the time given to the representatives of the personnel to perform their elective mandate and to ensure more transparency in their activities, by indicating, inter alia, the percentage of time worked in the framework of their mandate, as well as the training, activities and ensuing results. Department Head Office HR Department

  2. Administrative circular n°23 (Rev. 3) – Special working hours

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 23 (Rev. 3) entitled “Special working hours”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to staff members and fellows. It cancels and replaces Administrative Circular No. 23 (Rev. 2) entitled “Special working hours” of December 2008. Paragraph 6 a) of Annex II of this circular was revised following the modification of Article III 1.04 of the Staff Regulations approved by Council on 14 December 2012. The modification serves to adapt the minimum rest time to the fact that, in case of rapidly alternating shifts, a maximum of seven consecutive shifts may be performed. Department Head Office HR Department

  3. Administrative circular n°11 (REV. 2) – Categories of members of the personnel

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 May 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department. This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 1) entitled “Categories of members of the personnel” of January 1997 as regards all contracts of members of the personnel issued on or after 1 January 2013. The circular was revised in order to take into account developments since the last revision of the categories of personnel in 1997 as well as the needs of the Organization and collaborating institutes. In particular, it introduces a new system for distinguishing categories of associated members of the personnel, namely with regard to the purpo...

  4. Administrative circular No. 20 (Rev. 2) – Use of private vehicules for journeys on official duty

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circular No. 20 (Rev. 2) entitled "Use of private vehicles for journeys on official duty", adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 January 2011, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 20 (Rev. 1) entitled "Use of private vehicles on official duty" of April 1993. This new version introduces, in particular, the payment of a kilometer allowance in case of emergency during standby duty or when on call and a simplified calculation of the allowance for journeys between sites. This circular also clarifies the type of permitted private vehicles. Department Head Office  

  5. Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

    Directory of Open Access Journals (Sweden)

    Dudley Jaquelin P

    2009-02-01

    Full Text Available Abstract Background Mouse mammary tumor virus (MMTV encodes the Rem protein, an HIV Rev-like protein that enhances nuclear export of unspliced viral RNA in rodent cells. We have shown that Rem is expressed from a doubly spliced RNA, typical of complex retroviruses. Several recent reports indicate that MMTV can infect human cells, suggesting that MMTV might interact with human retroviruses, such as human immunodeficiency virus (HIV, human T-cell leukemia virus (HTLV, and human endogenous retrovirus type K (HERV-K. In this report, we test whether the export/regulatory proteins of human complex retroviruses will increase expression from vectors containing the Rem-responsive element (RmRE. Results MMTV Rem, HIV Rev, and HTLV Rex proteins, but not HERV-K Rec, enhanced expression from an MMTV-based reporter plasmid in human T cells, and this activity was dependent on the RmRE. No RmRE-dependent reporter gene expression was detectable using Rev, Rex, or Rec in HC11 mouse mammary cells. Cell fractionation and RNA quantitation experiments suggested that the regulatory proteins did not affect RNA stability or nuclear export in the MMTV reporter system. Rem had no demonstrable activity on export elements from HIV, HTLV, or HERV-K. Similar to the Rem-specific activity in rodent cells, the RmRE-dependent functions of Rem, Rev, or Rex in human cells were inhibited by a dominant-negative truncated nucleoporin that acts in the Crm1 pathway of RNA and protein export. Conclusion These data argue that many retroviral regulatory proteins recognize similar complex RNA structures, which may depend on the presence of cell-type specific proteins. Retroviral protein activity on the RmRE appears to affect a post-export function of the reporter RNA. Our results provide additional evidence that MMTV is a complex retrovirus with the potential for viral interactions in human cells.

  6. Effects on birds of an offshore wind park at Horns Rev: Environmental impact assessment

    Energy Technology Data Exchange (ETDEWEB)

    Noer, H.; Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [DMU, Dept. of Coastal Zone Ecology (Denmark)

    2000-07-01

    This report presents the technical background to the ornithological environmental impact assessment for the construction of an offshore windpark at Horns Rev, 14 km west-south-west of Blaevandshuk, Denmark. Construction of the park is planned to commence in 2001. The park will consist of c. 80 wind turbines, each of at least 1.8 MW, and cover an area of 27.5 km{sup 2} (including the 200 m exclusion zone around the park). (au)

  7. Determination of Geometrical REVs Based on Volumetric Fracture Intensity and Statistical Tests

    Directory of Open Access Journals (Sweden)

    Ying Liu

    2018-05-01

    Full Text Available This paper presents a method to estimate a representative element volume (REV of a fractured rock mass based on the volumetric fracture intensity P32 and statistical tests. A 150 m × 80 m × 50 m 3D fracture network model was generated based on field data collected at the Maji dam site by using the rectangular window sampling method. The volumetric fracture intensity P32 of each cube was calculated by varying the cube location in the generated 3D fracture network model and varying the cube side length from 1 to 20 m, and the distribution of the P32 values was described. The size effect and spatial effect of the fractured rock mass were studied; the P32 values from the same cube sizes and different locations were significantly different, and the fluctuation in P32 values clearly decreases as the cube side length increases. In this paper, a new method that comprehensively considers the anisotropy of rock masses, simplicity of calculation and differences between different methods was proposed to estimate the geometrical REV size. The geometrical REV size of the fractured rock mass was determined based on the volumetric fracture intensity P32 and two statistical test methods, namely, the likelihood ratio test and the Wald–Wolfowitz runs test. The results of the two statistical tests were substantially different; critical cube sizes of 13 m and 12 m were estimated by the Wald–Wolfowitz runs test and the likelihood ratio test, respectively. Because the different test methods emphasize different considerations and impact factors, considering a result that these two tests accept, the larger cube size, 13 m, was selected as the geometrical REV size of the fractured rock mass at the Maji dam site in China.

  8. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2005-05-15

    Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

  9. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S B; Pedersen, John

    2005-05-15

    Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

  10. Losers, Food, and Sex. Clerical Masculinity in the BBC Sitcom Rev.

    Directory of Open Access Journals (Sweden)

    Alexander Ornella

    2016-11-01

    Full Text Available Clerical masculinities, much like their lay/secular counterparts, often appear unchang¬ing because they are the products of naturalization processes. Clerical masculinities, however, are far from stable, for they live and breathe the dynamics of both their socio-religious context and their secular “others”. The BBC sitcom Rev. (BBC2, UK 2010–2014 is a refreshing take on the everyday life and problems of a vicar in the Church of England trying to avoid stereotypes that often come with clerical roles. Rev. (2010–2014 can be interpreted as an attempt to explore the negotiation processes of masculinity within an institution that is involved in the “production” of religion and gender roles. It shows that being a man in an institutional setting is as much a perfor¬mance as it is a more or less successful negotiation of other people’s expectations and one’s own worldview. In particular, the main male clerical characters in Rev. (2010– 2014 inhabit a position of power but all have their flaws. They can best be understood as losers whose clash with masculine systems renders them more human.

  11. Guidance and considerations for implementation of INFCIRC/225/Rev.3, the physical protection of nuclear material

    International Nuclear Information System (INIS)

    1997-09-01

    The Physical Protection of Nuclear Material, INFCIRC/225/Rev.3, provides recommendations for the physical protection of nuclear material against theft in use, storage and transport, whether national or international and whether peaceful or military, and contains provisions relating to the sabotage of nuclear material or facilities. The recommendations contained in INFCIRC/225/Rev.3 detail the elements that should be included in a State's system of physical protection. It also recognizes the adverse health and safety consequences arising from the theft of nuclear material and the sabotage of nuclear material or facilities. Most industrial and developing countries use these recommendations to some extent in the establishment and operation of their physical protection systems. Although INFCIRC/225/Rev.3 provides recommendations for protecting materials and facilities from theft or sabotage, it does not provide in-depth details for these recommendations. In June 1996, the IAEA convened a consultants meeting to consider this matter. This report is the result of continuing discussions and drafts over a period of nine months. The intent of this guidance is to provide a broader basis for relevant State organizations to prescribe appropriate requirements for the use of nuclear materials which are compatible with accepted international practice

  12. Approches par points de vue pour l’ingénierie des Systèmes d’information

    Directory of Open Access Journals (Sweden)

    Brahim Lahna

    2009-07-01

    Full Text Available Les concepts de point de vue, de rôle, de perspective et de vue ont été largement étudiés et utilisés dans de nombreux travaux, dans divers domaines de l’informatique. On retrouve ces notions dans les Systèmes de Représentation de Connaissances par Objets, les Bases de Données Orientées Objets, les Méthodes de Conception, la Programmation Orientée Objets, etc. Chaque domaine lui donne sa propre définition et l’utilise dans son propre contexte. La notion de vue se développe indépendamment dans ces différentes disciplines. Bien que les propositions différent, elles sont confrontées aux mêmes problèmes : établir des relations entre vues et garantir la cohérence des vues entre elles ou vis-à-vis d'un modèle de référence. Nous présentons dans cet article des travaux relatifs aux notions de vues et points de vue dans différentes disciplines informatiques en insistant sur une proposition originale pour une nouvelle ingénierie des systèmes d’information orientée perspectives et composants multivues réutilisables.

  13. Estudio de Impacto Ambiental de una Granja de Gallinas Ponedoras en Producción Ecológica en el término municipal de Iznalloz, Granada

    OpenAIRE

    MARTÍNEZ AYALA, ANTONIO JOSÉ

    2012-01-01

    El proyecto consiste en la construcción de una granja de huevos ecológicos en la comarca de Los Montes situada en la zona norte de la provincia de Granada, con los siguientes fines: -¿Producción de huevos ecológicos cubriendo así, la creciente demanda de la sociedad, cada vez más comprometida con el consumo responsable. -Fomentar la producción de huevos ecológicos respecto a la producción convencional. -¿Favorecer el desarrollo sostenible y el desarrollo local con sist...

  14. Etude empirique de la relation entre le système monétaire et financier et la croissance économique

    OpenAIRE

    Ouni, Moez; Nejadan-Zarin, Milad

    2011-01-01

    La problématique de la relation entre le système financier, et de ses effets, et la croissance économique reste une question controversée. Elle est sujet d’un débat animé entre les différentes tendances économiques. L’objectif de la présente thèse est d’apporter des éclairages sur la nature de ladite relation. Pour atteindre cet objectif, Nous avons considéré le système financier composé du système bancaire, y compris la banque centrale, et de la bourse de valeurs, et la croissance économique...

  15. Status report of seabird surveys at Horns Rev, 2000-2001

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

    2002-01-01

    The present report presents the results of three bird surveys conducted in the Horns Rev area during the second half of 2001. Due to poor weather conditions in December 2001, the last survey was, however, performed on 7 January 2002. The surveys are part of the base-line investigations of birds performed in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. The results of the surveys during August 2001 - January 2002 are presented together with the results obtained during the period August 2000 - April 2001, and are also compared to results obtained during the period August 1999 - April 2000. Based on the distribution of the most abundant bird species recorded during 16 aerial surveys performed during August 1999 - January 2002, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, mainly occurring in the areas north and south of Horns Rev, and with low numbers on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common Scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although common scoter was found in relatively high numbers on the southeast slopes of the Horns Rev and within the wind farm area in the April 2001 survey. Common scoters occurred in very high numbers in January 2002. This was probably related to increased immigration of birds from the inner Danish waters during a cold period in late December 2001. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affect less than 1% of the various species, except divers where 1.58% will be

  16. Revisión del paradigma ecológico de la 'legionella'. Estrategia ecológica y su implicación en salud pública

    Directory of Open Access Journals (Sweden)

    José Bernardo Ferrer Simó

    2008-12-01

    Full Text Available Algunos aspectos difícilmente explicados por el modelo ecológico descrito por Rowbothan en 1980, como son: la dosis infecciosa anormalmente baja, las largas distancias en las cuales la bacteria permanece viable en el seno del aerosol difundido, la dificultad de crecimiento en los medios de cultivo estándar, la poca eficacia de los desinfectantes antilegionela en el control de los brotes, la reinfección o sencillamente la ausencia de transmisión persona-persona, son analizados bajo el prisma de la microbiología ecológica. Centrados en la relación bacteria-protozoo, diversos estudios sugieren que la amplificación o crecimiento bacteriano podría tener lugar en dos fases o etapas, funcionalmente distintas, según la proporción o ratio bacteria-ameba (MOI- multiplicity of infection. En una primera fase de crecimiento rápido, en la que esta relación es sustancialmente baja, la entrada de una bacteria de legionela en la ameba originaría una única vacuola, que tras la lisis amebiana, liberaría al medio formas libres infectantes para otras amebas. La segunda etapa, de diseminación o colonización de otros nichos ecológicos, con relaciones MOI altas, se producen varias vesículas de crecimiento en el interior de la ameba que serían expulsadas por la misma sin necesidad de lisar. El enquistamiento de la ameba en esta fase, se produce tras la liberación masiva al medio de las vesículas que hubiera en el interior. Algunos autores sugieren que estas vesículas por sus características de resistencia y “empaquetamiento” de formas de vivas de legionela, constituyen el núcleo infectante en la transmisión de la legionelosis. La presencia de un biofilm específico podría ser determinante en este proceso. Teniendo en cuenta este sistema de relación-interacción ameba-legionela, las medidas preventivas deberían ir encaminadas a mantener la relación MOI baja, siempre en conjunción con bajos niveles de biofilm. En este sentido la adici

  17. Tentative d'évaluation du systéme d'information marketing au niveau des banques publiques Algériennes

    OpenAIRE

    Hassaine-kazi-tani, Amel

    2014-01-01

    Le premier chapitre présente les fondements théoriques relatifs au marketing, marketing des services et notamment le marketing bancaire.dans le deuxiéme chapitre seront développées les notions de base du concept d'information et celui de systéme d'information et puis le systéme d'information marketing.le troisiéme chapitre pratique présente une étude de cas auprés des banques publiques Algériennes.

  18. Garantías Ambientales en la Constitución: Un nuevo modelo ecológico-político para Costa Rica y el resto del mundo

    Directory of Open Access Journals (Sweden)

    Gabriel Quesada A

    2009-09-01

    Full Text Available La Constitución Política de Costa Rica incluye un párrafo sobre el derecho a un ambiente sano, la responsabilidad del Estado a garantizar, defender y preservar ese derecho, así como la acción popular (Artículo 50. Sin embargo, es fundamental incluir en la Constitución un título de Derechos y Garantías Ambientales donde el Estado garantice, defienda y preserve el derecho a un ambiente biofísico y humano ecológicamente sostenible, donde se mantenga el dominio público sobre los elementos del ambiente, y se regule su uso y aprovechamiento de conformidad con las reglas de la ciencia y la técnica. Costa Rica sería el primer país en el mundo con un título constitucional de Derechos y Garantías Ambientales y daría el ejemplo a otras naciones en materia ambiental. Las Garantías Ambientales serán un instrumento ágil y eficiente para proteger el ambiente.Environmental Guarantees in the Constitution: a new ecological-political model for Costa Rica and the rest of the world. In the last thirty years significant changes to protect the environment have been introduced in the judicial, administrative and social systems. Costa Rica is a well known international model in the field of sustainable development, and here I present a proposal for adding environmental gaurantees to the Costa Rican Constitution. One of the most important changes in the Costa Rican judicial system has been the introduction of an environmental amendment in the Constitution (Article 50. However, it is still fundamental to introduce a Title of Environmental Guarantees in the Constitution of Costa Rica, with these components: first, the State, the public and the private sector have the duty of defending the right to a safe environment; second, public domain over environmental issues, and third, the use of the environment should be regulated by scientific and technical knowledge. If current efforts succeed, Costa Rica will be the first country in the world to include

  19. DC Brushless Motor Control Design and Preliminary Testing for Independent 4-Wheel Drive Rev-11 Robotic Platform

    Directory of Open Access Journals (Sweden)

    Roni Permana Saputra

    2012-03-01

    Full Text Available This paper discusses the design of control system for brushless DC motor using microcontroller ATMega 16 that will be applied to an independent 4-wheel drive Mobile Robot LIPI version 2 (REV-11. The control system consists of two parts which are brushless DC motor control module and supervisory control module that coordinates the desired command to the motor control module. To control the REV-11 platform, supervisory control transmit the reference data of speed and direction of motor to control the speed and direction of each actuator on the platform REV-11. From the test results it is concluded that the designed control system work properly to coordinate and control the speed and direction of motion of the actuator motor REV-11 platform. 

  20. Évaluation de l'apport des pluies prévues par le système opérationnel AROME-PI dans le système Vigicrues-Flash

    OpenAIRE

    Demargne, J.; Javelle, P.

    2016-01-01

    / Cette étude a été réalisée pour le SCHAPI (Service Central d'Hydrométéorologie et d'Appui à la Prévision des Inondations) pour analyser l'amélioration du système d'avertissement sur la possibilité de crues rapides en intégrant des prévisions de pluie future à courte échéance et fine résolution spatio-temporelle et en prenant en compte leurs incertitudes. Le SCHAPI développe actuellement un service d'avertissement automatisé valable sur l'ensemble de la France, appelé Vigicrues-Flash, qui de...

  1. Regionalización ecológica de la llanura costera norte de Nayarit, México

    Directory of Open Access Journals (Sweden)

    Areli González García Sancho

    2009-10-01

    Full Text Available El estado de Nayarit se localiza al noroeste de la República Mexicana; en su territorio confluyen cuatro importantes Provincias Fisiográficas; Sierra Madre Oriental, Cinturón Volcánico Trans-Mexicano, Sierra Madre del Sur y la Llanura Costera del Pacífico. Cada una de ellas tiene un sustrato geológico específico como repuesta a una génesis diferente, estas características favorecen la existencia de marcadas diferencias de altura en distancias cortas y por tanto un potencial en la variedad geomorfológica y climática, estos aspectos son los responsables de la existencia de una diversidad de paisajes. La Llanura Costera del Pacífico ocupa un pequeño sector localizado al noroeste del estado y representa 445 069 ha, en esta superficie se hace una regionalización ecológica que tiene como punto de partida la caracterización de unidades geomorfopedológicas; de cobertura del terreno y uso del suelo. Con este fin se desarrolló un sistema de clasificación jerárquica que define ambientes, paisajes y subpaisajes geomorfológicos, a los cuales se asociaron datos edafológicos. Por otra parte, se realizó el levantamiento de cobertura y de uso del suelo mediante el empleo de ortofotos digitales, imágenes de satélite, cartografía temática (1:50 000, verificación de campo y descripción de puntos con barrena. Los resultados obtenidos se integraron y analizaron utilizando un sistema de información geográfica ArcView 3.2, de esta manera fue posible identificar 58 regiones ecológicas, agrupadas en 11 subpaisajes, cuatro paisajes geomorfológicos y dos regiones geomorfológicas.

  2. Abelhas sem ferrão (Hymenoptera: Apidae, Meliponini da Estação Ecológica de Água Limpa, Cataguases-MG, Brasil.

    Directory of Open Access Journals (Sweden)

    Hugo Werneck

    2014-08-01

    Stingless Bees of the Estação Ecológica de Água Limpa, Cataguases-MG, Brazil Abstract. This study carried out a survey of nests of stingless bees present in the Estação Ecológica de Água Limpa (EEAL in the municipality of Cataguases, Minas Gerais. We found twenty-one nests belonging to nine species: Friesella schrottkyi (Friese, Melipona bicolor Lepeletier, Plebeia sp. 1, Plebeia sp. 2, Tetragona clavipes (Fabricius, Tetragona quadrangula (Fabricius, Tetragonisca angustula (Latreille, Trigona hyalinata (Lepeletier, Trigona spinipes (Fabricius. Twenty of the 21 nests were found in arboreal substrate. The fauna of stingless bees observed in EEAL is represented by a low number of species. Although the local vegetation has the potential to provide substrates for nesting and floral resources, the low species richness may be related to the fact that the EEAL is an isolated forest remnant.

  3. Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.

    2000-03-15

    An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

  4. Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S B

    2000-03-15

    An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

  5. Bird numbers and distributions in the Horns Rev offshore wind farm area. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Krag Petersen, I.

    2005-07-01

    This report presents data from four aerial surveys of birds in the Horns Rev wind farm area in 2004. Three surveys from the winter and spring of 2004 are thoroughly reported here. The fourth survey of 9 September 2004 is reported in general terms, but not included in presentations of distribution and effect analyses of the wind farm. Data from this survey will be thoroughly dealt with in a future report. Including the four surveys of 2004, a total of 29 surveys have been performed in that area since August 1999. (au)

  6. Pilot power based rate control in CDMA 2000 1x EV-DO Rev-A

    Institute of Scientific and Technical Information of China (English)

    LIU Xiao-feng; GU Jian; YANG Hong-wen

    2008-01-01

    This article proposes a new algorithm to improvethe rate control efficiency of enhanced reverse link mediumaccess control (RLMAC) in the code division multiple access(CDMA) lx EV-DO release A(Rev. A) system. The newalgorithm brings reverse access terminal (AT) pilot power tothe RLMAC rate control procedure and makes it easier for alow pilot power user to increase its data rate when the systemis slightly loaded and harder to decrease its date rate when thesystem is heavily loaded. Numerical results of system levelsimulations show that the new algorithm can bring highersystem throughput, lower AT transmission power, and lowersystem load.

  7. Simulaton of the Avedøreværket Unit 1 Cogeneration Plant with DNA

    DEFF Research Database (Denmark)

    Elmegaard, Brian; Houbak, Niels

    2003-01-01

    The simulator contest proposed for the ECOS 2003 conference has been solved using the DNA energy system simulator. The contest concerns the steam process of the Avedøreværket Unit 1 (AVV1) power plant. The plant is a 250 MWCHP plant with a maximum district heat production of 330 MJ/s. The plant has...... a net electric efficiency of 42% and a maximum energy utilization of 92%. In this paper it is demonstrated, that the DNA model of AVV1 can calculate the whole flow sheet balance at any load point, i.e., any possible combination of power production and district heat production. The paper also contains...

  8. A novel, mouse mammary tumor virus encoded protein with Rev-like properties

    International Nuclear Information System (INIS)

    Indik, Stanislav; Guenzburg, Walter H.; Salmons, Brian; Rouault, Francoise

    2005-01-01

    We have identified a novel, multiple spliced, subgenomic mRNA species in MMTV producing cells of different origin containing an open reading frame encoding a 39-kDa Rev-like protein, Rem (regulator of expression of MMTV). An EGFP-Rem fusion protein is shown to be predominantly in the nucleolus. Further leptomycin B inhibits the nuclear export of nonspliced MMTV transcripts, implicating Rem in nuclear export by the Crm1 pathway in MMTV. Rem is thus reminiscent of the Rec protein from the related endogenous human retrovirus, HERV-K

  9. Permeability computation on a REV with an immersed finite element method

    International Nuclear Information System (INIS)

    Laure, P.; Puaux, G.; Silva, L.; Vincent, M.

    2011-01-01

    An efficient method to compute permeability of fibrous media is presented. An immersed domain approach is used to represent the porous material at its microscopic scale and the flow motion is computed with a stabilized mixed finite element method. Therefore the Stokes equation is solved on the whole domain (including solid part) using a penalty method. The accuracy is controlled by refining the mesh around the solid-fluid interface defined by a level set function. Using homogenisation techniques, the permeability of a representative elementary volume (REV) is computed. The computed permeabilities of regular fibre packings are compared to classical analytical relations found in the bibliography.

  10. Fundamental study on REV based on crack tensor at the Mizunami Underground Research Laboratory

    International Nuclear Information System (INIS)

    Tanno, Takeo; Sato, Toshinori; Sanada, Hiroyuki; Hikima, Ryoichi; Kumasaka, Hiroo; Tada, Hiroyuki

    2013-01-01

    The crack tensor model which is a kind of equivalent continuum model has been studied in rock mechanical investigation in the MIU. The fractured rock mass is modeled as the elastic continuum model with this crack tensor. In this study, this crack tensor based on the geological observation in the MIU project was calculated, and Representative Elementary Volume (REV) in the ventilation shaft and -300 m access/research gallery was studied based on the relative error of this crack tensor. As a result, the convergence of the relative error was faster in the -300 m access/research gallery than in the ventilation shaft. (author)

  11. El uso de especies vegetales exóticas como una estrategia de restauración ecológica

    OpenAIRE

    Maglianesi Sandoz, Maria Alejandra

    2016-01-01

    El presente artículo describe el desarrollo de programas de reforestación en Costa Rica y el uso de especies vegetales exóticas para la recuperación de tierras degradadas en los trópicos. Se lleva a cabo un análisis de las ventajas y desventajas del uso de estas especies en programas de restauración ecológica.

  12. Entre la economía política de Karl Marx y la economía ecológica

    Directory of Open Access Journals (Sweden)

    Julián Sabogal Tamayo

    2012-12-01

    Full Text Available Este artículo intenta contribuir a la discusión sobre las diferencias y afinidades entre la economía política de Marx y la economía ecológica. Se centra en las diferencias de objetivos, de temas de estudio y de métodos. También señala los puntos de convergencia y la necesidad de la solidaridad y del aprendizaje mutuo.

  13. Assimilation des débits dans le modèle hydrologique du système AIGA

    OpenAIRE

    Demargne, J.; Javelle, P.

    2015-01-01

    / Cette étude a été réalisée pour le SCHAPI (Service Central d'Hydrométéorologie et d'Appui à la Prévision des Inondations) et l'Irstea pour tester l'impact d'une assimilation des observations de débit sur les performances du système d'avertissement aux crues rapides AIGA. En collaboration avec l'IRSTEA, le SCHAPI développe actuellement un service d'avertissement automatisé valable sur l'ensemble de la France, qui sera complété par un service expertisé d'avertissement sur des bassins dits pri...

  14. Utilité du système expert Climprod pour la connaissance du déterminisme du recrutement

    OpenAIRE

    Fréon, Pierre; Kwiecinski, B.; Lopez, D.

    1992-01-01

    Une vingtaine de modèles globaux de production comportant une variable climatique ont été proposés (Fréon, 1986). CLIMPROD est un système expert qui permet de choisir, parmi ces modèles, le mieux adapté au stock considéré en fonction de critères objectifs ou empiriques. Le modèle retenu est ensuite ajusté aux données par régression non-linéaire, puis validé par des tests non-paramétriques (jacknife). A partir de quelques exemples pris dans des régions de remontées d'eau profonde, on montre le...

  15. Le système du risque à Saint-Martin (Petites Antilles françaises

    Directory of Open Access Journals (Sweden)

    Virginie Duvat

    2008-11-01

    Full Text Available L’île de Saint-Martin constitue un terrain particulièrement intéressant pour étudier le système du risque naturel et les conditions de la co-évolution territoire/catastrophes. Les mécanismes qui s’y observent renforcent sa vulnérabilité et l’efficacité du retour d’expérience est affaiblie par des blocages d’ordre politique et juridique.The island of Saint-Martin is an interesting case study for a systemic approach applied to cyclone hazards and the co-evolution of territory and disaster management. The mecanisms which can be observed increase its vulnerability and the progress of hazard management policies is weakened by political and juridical bottlenecks.

  16. L'impact d'une démarche d'alignement stratégique du système d'information sur la stratégie de l'entreprise Cas de SONATRACH

    OpenAIRE

    Taieb Errahmani, Mohamed

    2014-01-01

    Le management des systèmes d'information et des technologies de l'information a apporté de nombreux concepts et pratiques, à savoir ; la gouvernance IT, la gestion stratégique des systèmes d’information… etc. Le concept d’alignement stratégique du système d'information rassemble deux axes principaux, soit ; la stratégie du système d’information et la stratégie de l'entreprise. L'objectif principal de cette étude est de mettre en évidence l'impact d’une démarche d'alignement des systèmes d'inf...

  17. PERSOREC : un système personnalisé de recommandations pour les folksonomies basé sur les concepts quadratiques

    OpenAIRE

    Jelassi , Mohamed Nader; Ben Yahia , Sadok; Mephu Nguifo , Engelbert

    2015-01-01

    National audience; Ce papier présente un nouveau système personnalisé de recommandations pour les folksonomies basé sur les concepts quadratiques.; This paper introduces a new personalized recommender system for folksonomies based on quadratic concepts.

  18. Predikční systém ELVÍRA pro predikci spotřeby zemního plynu

    Czech Academy of Sciences Publication Activity Database

    Pelikán, Emil; Eben, Kryštof; Šimůnek, Milan; Kolman, M.; Hais, J.

    2000-01-01

    Roč. 80, č. 11 (2000), s. 253-255 ISSN 0032-1761 Institutional research plan: AV0Z1030915 Keywords : predikční modely * systémy pro podporu rozhodování * regresní metody * umělé neuronové sítě Subject RIV: BB - Applied Statistics, Operational Research

  19. Las microalgas de Tillandsia multicaulis Steud. (Bromeliaceae de la Reserva Ecológica “La Martinica”, Veracruz

    Directory of Open Access Journals (Sweden)

    Brisceida Hernández-Rodríguez

    2014-01-01

    Full Text Available Las bromelias tienen la capacidad de retener agua en las axilas de las hojas lo que es conocido como tanques o fitotelmata; mantienen cadenas tróficas complejas con todo tipo de organismos, desde bacterias hasta vertebrados pequeños. En este trabajo, presentamos la primera aproximación a las microalgas que viven en las cisternas de una especie de bromelia en la Reserva Ecológica “La Martinica” en Banderilla, Veracruz. Las recolecciones se estudiaron en material preservado y en cultivos. Se obtuvieron cerca de 60 algas pertenecientes a las Cyanoprokariota, Euglenophyta, Cryptophyta, Chlorophyta y Bacillariophyta, sin embargo, solo se lograron identificar 16 especies. Se concluye que los tanques de Tillandsia multicaulis brindan las condiciones adecuadas para el desarrollo de microalgas y que la ubicación y la morfología de la bromelia influyen en la distribución de este grupo biológico. La escasez de individuos en las muestras analizadas no permitió una identificación precisa de todas las especies. En los cultivos aparecieron especies no observadas en el material preservado, lo que indica una flora mucho más rica de la que puede observarse directamente.

  20. Un estudio ecológico del voto socialista en el medio rural-urbano andaluz, 1999-2012

    Directory of Open Access Journals (Sweden)

    Carmen Ortega

    2015-01-01

    Full Text Available Este artículo pretende contribuir a reforzar los estudios electorales en España, ampliando su especialización temática y metodológica, con la realización de un estudio ecológico del voto. En concreto, se exploran, desde un enfoque agregado, las relaciones entre el tipo de hábitat y el voto socialista en los distintos procesos celebrados en Andalucía, desde 1999 hasta 2012. Nuestro análisis empírico comprende dos aproximaciones: la primera ofrece una geografía del voto más descriptiva que explicativa, donde se muestra que tanto la participación como el voto al PSOE se asocia de forma negativa con el grado de urbanización; la segunda, mediante modelos de regresión espaciales, indaga las bases socioestructurales y muestra que el voto socialista se asocia a la inestabilidad y precariedad económica de las localidades ?fundamentalmente tasas de desempleo y de población agraria subsidiada?, especialmente en las elecciones generales y autonómicas.

  1. Anatomía ecológica de algunas especies del género Paspalum (Poaceae, Panicoideae, Paniceae

    Directory of Open Access Journals (Sweden)

    Sandra S. Aliscioni

    2000-01-01

    Full Text Available Aliscioni, S. S. 2000. Anatomía ecológica de algunas especies del género Paspalum(Poaceae, Panicoideae, Paniceae. Darwiniana 38(3-4: 187-207.El género Paspalum L. presenta un elevado número de especies, con una amplia variabilidadmorfológica y una extensa distribución geográfica. Sus especies crecen en hábitats sumamente diversos,desde ambientes muy húmedos o acuáticos, a lugares secos de suelos arcillosos o arenosos, muchas vecessalinos. Dada la diversidad de ambientes en los que puede hallarse Paspalum, se estudiaron lascaracterísticas anatómico-foliares presentes en el género con la finalidad de interpretar diferentesestrategias adaptativas en distintas especies. Se presenta una descripción general de la anatomía foliar delgénero y se discuten ciertos caracteres anatómicos, interpretando su posible relación con las condicionesdel hábitat

  2. High amplitude phase resetting in rev-erbalpha/per1 double mutant mice.

    Directory of Open Access Journals (Sweden)

    Corinne Jud

    Full Text Available Over time, organisms developed various strategies to adapt to their environment. Circadian clocks are thought to have evolved to adjust to the predictable rhythms of the light-dark cycle caused by the rotation of the Earth around its own axis. The rhythms these clocks generate persist even in the absence of environmental cues with a period of about 24 hours. To tick in time, they continuously synchronize themselves to the prevailing photoperiod by appropriate phase shifts. In this study, we disrupted two molecular components of the mammalian circadian oscillator, Rev-Erbalpha and Period1 (Per1. We found that mice lacking these genes displayed robust circadian rhythms with significantly shorter periods under constant darkness conditions. Strikingly, they showed high amplitude resetting in response to a brief light pulse at the end of their subjective night phase, which is rare in mammals. Surprisingly, Cry1, a clock component not inducible by light in mammals, became slightly inducible in these mice. Taken together, Rev-Erbalpha and Per1 may be part of a mechanism preventing drastic phase shifts in mammals.

  3. Validation of CATHENA MOD-3.5/Rev0 for single-phase water hammer

    International Nuclear Information System (INIS)

    Beuthe, T.G.

    2000-01-01

    This paper describes work performed to validate the system thermalhydraulics code CATHENA MOD-3.5c/Rev0 for single-phase water hammer. Simulations were performed and are compared quantitatively against numerical tests and experimental results from the Seven Sisters Water Hammer Facility to demonstrate CATHENA can predict the creation and propagation of pressure waves when valves are opened and closed. Simulations were also performed to show CATHENA can model the behaviour of reflected and transmitted pressure waves at area changes, dead ends, tanks, boundary conditions, and orifices in simple and more complex piping systems. The CATHENA results are shown to calculate pressure and wave propagation speeds to within 0.2% and 0.5% respectively for numerical tests and within 3.3% and 5% for experimental results respectively. These results are used to help validate CATHENA for use in single-phase water hammer analysis. They also provide assurance that the fundamental parameters needed to successfully model more complex forms of water hammer are accounted for in the MOD-3.5c/Rev0 version of CATHENA, and represent the first step in the process to validate the code for use in modelling two-phase water hammer and condensation-induced water hammer. (author)

  4. Technical reports retrieval system(rev. 1) in the field of nuclear energy

    International Nuclear Information System (INIS)

    Choi, S.D.; Lee, Y.K.; Yim, S.H.

    1983-01-01

    TRRS(rev. 1), on-line Technical Reports Retrieval System, a set of computer programs, was designed and developed to provide fast and efficient access to computer-based information files. This system was foucused upon its application to the retrival of technical reports collected in KAERI, and developed not only to meet the requirements of researchers sitting at terminal but to accomodate its sufficiently general logic to other computer systems. The retrival program language is FORTRAN IV Plus. The users can search the whole files using next eleven TRRS(rev. 1) commands, HELP, SEARCH, LOOK, COMBINE, EXPAND, SELECT, REVIEW, RESTART, TYPE, PRINT, and END. The special features of this system are as follows. First, the SEARCH command can process full and truncation (truncation mark is %), and can combine such truncated terms using Boolean operators, and (*), and and-not (.). Second, COMBINE command can combine set numbers with year(s), language(s) and a substring of titles. Third, after EXPAND command, either full or truncated term, SELECT command brings same result of SEARCH command. Finally, real time response is very short, real time response is very short, usually within a second or less. (Author)

  5. Benchmark test of JENDL-3T and -3T/Rev.1

    International Nuclear Information System (INIS)

    Takano, Hideki; Kaneko, Kunio.

    1989-10-01

    The fast reactor 70-group constant set JFS-3-J3T has been generated by using the JENDL-3T nuclear data. One-dimensional 21-benchmark cores and the ZPPR-9 core were analysed with the JFS-3-J3T set. The results obtained are summarized as follows: (1) The values of keff are underestimated by 0.6% for Pu-fueled cores and overestimated by 2% for U-fueled cores. (2) The central reaction rate ratio 239 σ f φ/ 235 σ f φ is in a good agreement with the experimental value, though 238 σ c φ/ 239 σ f φ and 238 σ f φ/ 235 σ f φ are overestimated. (3) Doppler and Na-void reactivities are in a good agreement with the measured data. (4) The prediction accuracy of radial reaction rate distributions are improved in the comparison of the results obtained with the JENDL-2 data. Furthermore, the benchmark test of JENDL-3T/Rev. 1 which was revised from JENDL-3T for several important nuclides has been again performed. It was shown that JENDL-3T/Rev. 1 would predict nuclear characteristics more satisfactorily than JENDL-3T. (author)

  6. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.

    Directory of Open Access Journals (Sweden)

    Keith I Pardee

    2009-02-01

    Full Text Available Heme is a ligand for the human nuclear receptors (NR REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO, and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD. A 1.9 A crystal structure of the REV-ERBbeta LBD, in complex with the oxidized Fe(III form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBbeta complex reveal that the Fe(II form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions.

  7. The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

    Science.gov (United States)

    Pardee, Keith I; Xu, Xiaohui; Reinking, Jeff; Schuetz, Anja; Dong, Aiping; Liu, Suya; Zhang, Rongguang; Tiefenbach, Jens; Lajoie, Gilles; Plotnikov, Alexander N; Botchkarev, Alexey; Krause, Henry M; Edwards, Aled

    2009-01-01

    Heme is a ligand for the human nuclear receptors (NR) REV-ERBα and REV-ERBβ, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO), and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD). A 1.9 Å crystal structure of the REV-ERBβ LBD, in complex with the oxidized Fe(III) form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBβ complex reveal that the Fe(II) form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II) LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions. PMID:19243223

  8. VIC–CropSyst-v2: A regional-scale modeling platform to simulate the nexus of climate, hydrology, cropping systems, and human decisions

    Directory of Open Access Journals (Sweden)

    K. Malek

    2017-08-01

    Full Text Available Food supply is affected by a complex nexus of land, atmosphere, and human processes, including short- and long-term stressors (e.g., drought and climate change, respectively. A simulation platform that captures these complex elements can be used to inform policy and best management practices to promote sustainable agriculture. We have developed a tightly coupled framework using the macroscale variable infiltration capacity (VIC hydrologic model and the CropSyst agricultural model. A mechanistic irrigation module was also developed for inclusion in this framework. Because VIC–CropSyst combines two widely used and mechanistic models (for crop phenology, growth, management, and macroscale hydrology, it can provide realistic and hydrologically consistent simulations of water availability, crop water requirements for irrigation, and agricultural productivity for both irrigated and dryland systems. This allows VIC–CropSyst to provide managers and decision makers with reliable information on regional water stresses and their impacts on food production. Additionally, VIC–CropSyst is being used in conjunction with socioeconomic models, river system models, and atmospheric models to simulate feedback processes between regional water availability, agricultural water management decisions, and land–atmosphere interactions. The performance of VIC–CropSyst was evaluated on both regional (over the US Pacific Northwest and point scales. Point-scale evaluation involved using two flux tower sites located in agricultural fields in the US (Nebraska and Illinois. The agreement between recorded and simulated evapotranspiration (ET, applied irrigation water, soil moisture, leaf area index (LAI, and yield indicated that, although the model is intended to work on regional scales, it also captures field-scale processes in agricultural areas.

  9. VIC-CropSyst-v2: A regional-scale modeling platform to simulate the nexus of climate, hydrology, cropping systems, and human decisions

    Science.gov (United States)

    Malek, Keyvan; Stöckle, Claudio; Chinnayakanahalli, Kiran; Nelson, Roger; Liu, Mingliang; Rajagopalan, Kirti; Barik, Muhammad; Adam, Jennifer C.

    2017-08-01

    Food supply is affected by a complex nexus of land, atmosphere, and human processes, including short- and long-term stressors (e.g., drought and climate change, respectively). A simulation platform that captures these complex elements can be used to inform policy and best management practices to promote sustainable agriculture. We have developed a tightly coupled framework using the macroscale variable infiltration capacity (VIC) hydrologic model and the CropSyst agricultural model. A mechanistic irrigation module was also developed for inclusion in this framework. Because VIC-CropSyst combines two widely used and mechanistic models (for crop phenology, growth, management, and macroscale hydrology), it can provide realistic and hydrologically consistent simulations of water availability, crop water requirements for irrigation, and agricultural productivity for both irrigated and dryland systems. This allows VIC-CropSyst to provide managers and decision makers with reliable information on regional water stresses and their impacts on food production. Additionally, VIC-CropSyst is being used in conjunction with socioeconomic models, river system models, and atmospheric models to simulate feedback processes between regional water availability, agricultural water management decisions, and land-atmosphere interactions. The performance of VIC-CropSyst was evaluated on both regional (over the US Pacific Northwest) and point scales. Point-scale evaluation involved using two flux tower sites located in agricultural fields in the US (Nebraska and Illinois). The agreement between recorded and simulated evapotranspiration (ET), applied irrigation water, soil moisture, leaf area index (LAI), and yield indicated that, although the model is intended to work on regional scales, it also captures field-scale processes in agricultural areas.

  10. Espécies de Melastomataceae Juss. com potencial para restauração ecológica de mata ripária no cerrado

    Directory of Open Access Journals (Sweden)

    Lidiamar Albuquerque

    2015-08-01

    Full Text Available Melastomataceae Juss. é a sexta família em importância no bioma Cerrado, sendo comuns em vegetação secundária. As espé-cies desta família apresentam estratégias de vida e adaptações como grande produção de sementes, dispersão efi ciente de propágulos, altas taxas de germinação e crescimento rápido que podem propiciar a ativação dos processos ecológicos envolvidos na rege-neração natural de habitats perturbados. O objetivo foi caracterizar as espécies de Melastomataceae em vegetação secundária e avaliar seu potencial para uso na restauração ecológica de áreas degradadas de matas ripárias. Este estudo foi realizado na área experimental da Embrapa Cerrados, à margem direita do córrego Sarandi, Distrito Federal, Brasil, em uma área de um hectare, onde foram instadas parcelas e transectos para avaliação dos parâmetros: caracterís-ticas botânicas, ecológicas e reprodutivas, síndromes de polinização e de dispersão de sementes, reprodução vegetativa, riqueza de espécies, abundância, cobertura, fenofases de floração e frutificação. A partir da análise destes parâmetros definiuse os critérios para avaliar o potencial de uso das espécies na restauração ecológica. Entre as 14 espécies da família de Melastomataceae registradas,Miconia chamissoisNaud. (35.42% e 42.53%,Ossaea congestiflora(Naud. Cong. (23.6% e 13.29%,Macairea radulaDC (19.66% e 17.22% eTococa formicariaMart. (6.78% e 3.87% apresentaram maior abundância e cobertura, respectivamente. As espécies estudadas apresentaram, em sua maioria, grande oferta de recursos ali-mentares ao longo do ano, que, associadas a outras características permitiram identifi car o potencial de restaurabilidade de cada espécie avaliada. O potencial para uso na res-tauração ecológica foi alto para as espécies:Miconia chamissois,Miconia ibaguensis,Miconia albicans,Miconia theaezanse Tococa formicaria. Estas espécies podem atuar como nucleadoras

  11. REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American.

    Science.gov (United States)

    Garaulet, Marta; Smith, Caren E; Gomez-Abellán, Purificación; Ordovás-Montañés, María; Lee, Yu-Chi; Parnell, Laurence D; Arnett, Donna K; Ordovás, José M

    2014-04-01

    Despite the solid connection between REV-ERB and obesity, the information about whether genetic variations at this locus may be associated with obesity traits is scarce. Therefore our objective was to study the association between REV-ERB-ALPHA1 rs2314339 and obesity in two independent populations. Participants were 2214 subjects from Spanish Mediterranean (n = 1404) and North American (n = 810) populations. Anthropometric, biochemical, dietary, and genotype analyses were performed. We found novel associations between the REV-ERB-ALPHA1 rs2314339 genotype and obesity in two independent populations: in Spanish Mediterranean and North American groups, the frequency of the minor-allele-carriers (AA+ AG) was significantly lower in the "abdominally obese" group than in those of the "nonabdominally obese" group (p obesity than noncarriers, and the effect was of similar magnitude for both populations (OR ≈ 1.50). There were consistent associations between REV-ERB-ALPHA1 genotype and obesity-related traits (p obesity was also detected in the Mediterranean population. This new discovery highlights the importance of REV-ERB-ALPHA1 in obesity and provides evidence for the connection between our biological clock and obesity-related traits. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Abordando las enfermedades respiratorias agudas en niños con un Enfoque Ecológico en la Comunidad

    Directory of Open Access Journals (Sweden)

    Francisco Lamus-Lemus

    2015-01-01

    Full Text Available Objetivos: Disminuir los episodios de enfermedad respiratoria aguda (ERA en las familias, mediante un enfoque modificado del modelo ecológico de Morelatto para identificar y tra-bajar colectivamente determinantes que influyen en la salud respiratoria de niños y niñas.Materiales y Métodos: Durante el proceso se realizaron actividades encaminadas a pre-venir las principales causas de ERA basadas en el modelo transteórico del comportamiento con el fin de generar cambios conductuales en las familias. Para ello se creó una escala de valoración del riesgo de ERA como instrumento de medición de la efectividad de las activi-dades realizadas, otorgándole a cada familia un puntaje antes y después de la intervención para determinar si hubo disminución del mismo. Resultados: Las actividades realizadas conducen a cambios evidenciados en las prácticas cotidianos de las madres y sus familias, reflejadas en la escala de valoración de riesgos a partir de la disminución de conductas que favorecen la enfermedad respiratoria aguda y sus complicaciones en la primera infancia afiliada a la FA R -Génesis.Conclusiones: Una menor exposición a eventos y complicaciones de la ERA en miembros de grupos familiares de la FA R -Génesis puede contribuir a mejorar la resiliencia y dismi-nuir la vulnerabilidad socioeconómica de las familias afectadas regularmente por la ERAsus complicaciones.

  13. De las áreas ecológicas significativas al Plan de Ordenamiento Territorial de Montevideo

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Bartorila

    2010-01-01

    Full Text Available En ámbitos metropolitanos el medio natural y el medio artificial pugnan y compiten uno sobre otro. Sus desarrollos, aparentemente desconectados, tienen importantes puntos en común. El interés por abordar, en un mismo nivel, los procesos que conforman los ecosistemas naturales y el artefacto urbano nos abren el camino al estudio de los ecosistemas en la ciudad y al urbanismo de redes (Dupuy, 1998. Este artículo presenta los resultados parciales de una investigación (tesis doctoral que pretende señalar la importancia de la determinación de las denominadas areas ecológicas significativas en la práctica del urbanismo. A través del análisis de caso de la ciudad de Montevideo, Uruguay, se caracterizan detalles de los aspectos espaciales y temporales de los ecosistemas naturales en la ciudad, señalando la manera en que se reconocen y se integran en el planeamiento territorial. Existen instrumentos de análisis y estudios que colaboran en la determinación espacialmente compleja de la realidad natural de los territorios. Será por medio de la revisión de trabajos de otros autores como se busca conocer la manera como ha sido estudiado e interpretado el conocimiento e interrelación de los ecosistemas y la ciudad, lo que permitirá en consecuencia, obtener instrumentos urbanísticos para delimitar y revalorizar los ecosistemas naturales intra y periurbanos.

  14. Administrative Circular No. 2 (Rev. 7) - Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Multimedia

    2015-01-01

    Administrative Circular No. 2 (Rev. 7), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion at the Standing Concertation Committee meeting held on 17 February 2015 is available via the following link: AC No. 2 (Rev.7).   This revised circular cancels and replaces Administrative Circular No. 2 (Rev. 6), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" and dated January 2015. The circular was revised in order to implement the amendment to Article R II 1.17 of the Staff Regulations, which introduces the possibility of extending limited-duration (LD) contracts up to a maximum total duration of eight years from the previous duration of five years. The award of indefinite contracts will continue to be subject to the outcome of a competitive process. Department Head Of...

  15. Administrative Circular No. 30 (Rev. 3) - “Financial benefits on taking up appointment and on termination of contract”

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 30 (Rev. 3) entitled “Financial benefits on taking up appointment and on termination of contract”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, is available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 30 (Rev. 3) is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 30 (Rev. 2/Corr.) entitled "Financial benefits on taking up appointment and on termination of contract” of September 2009. This circular was revised in order to implement the modifications introduced into the Staff Rules and Regulations in January 2013 relating to the introduction of the status of Associate Member States and new categories of associated members of the personnel. In particular, the notion of “Member State” in Annexe II (&a...

  16. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp These Circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover in particular lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you require any additional informa...

  17. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://https://hr-docs.web.cern.ch/hr-docs/admincirc/admincirc_fr.asp These circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover, in particular, lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you requi...

  18. Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

    International Nuclear Information System (INIS)

    1997-07-01

    The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

  19. Numerical Modelling of Large-Diameter Steel Piles at Horns Rev

    DEFF Research Database (Denmark)

    Augustesen, Anders Hust; Brødbæk, K. T.; Møller, M.

    2009-01-01

    Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used as founda......Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used...... as foundation for a wind turbine at Horns Rev located in the Danish sector of the North Sea. The outer diameter of the pile is 4 m and the subsoil at the location consists primarily of sand. The behaviour of the pile is investigated under realistic loading conditions by means of a traditional Winkler...

  20. Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels.

  1. Numerical modelling of powder caking at REV scale by using DEM

    Science.gov (United States)

    Guessasma, Mohamed; Silva Tavares, Homayra; Afrassiabian, Zahra; Saleh, Khashayar

    2017-06-01

    This work deals with numerical simulation of powder caking process caused by capillary condensation phenomenon. Caking consists in unwanted agglomeration of powder particles. This process is often irreversible and not easy to predict. To reproduce mechanism involved by caking phenomenon we have used the Discrete Elements Method (DEM). In the present work, we mainly focus on the role of capillary condensation and subsequent liquid bridge formation within a granular medium exposed to fluctuations of ambient relative humidity. Such bridges cause an attractive force between particles, leading to the formation of a cake with intrinsic physicochemical and mechanical properties. By considering a Representative Elementary Volume (REV), the DEM is then performed by means of a MULTICOR-3D software tacking into account the properties of the cake (degree of saturation) in order to establish relationships between the microscopic parameters and the macroscopic behaviour (tensile strength).

  2. Numerical modelling of powder caking at REV scale by using DEM

    Directory of Open Access Journals (Sweden)

    Guessasma Mohamed

    2017-01-01

    Full Text Available This work deals with numerical simulation of powder caking process caused by capillary condensation phenomenon. Caking consists in unwanted agglomeration of powder particles. This process is often irreversible and not easy to predict. To reproduce mechanism involved by caking phenomenon we have used the Discrete Elements Method (DEM. In the present work, we mainly focus on the role of capillary condensation and subsequent liquid bridge formation within a granular medium exposed to fluctuations of ambient relative humidity. Such bridges cause an attractive force between particles, leading to the formation of a cake with intrinsic physicochemical and mechanical properties. By considering a Representative Elementary Volume (REV, the DEM is then performed by means of a MULTICOR-3D software tacking into account the properties of the cake (degree of saturation in order to establish relationships between the microscopic parameters and the macroscopic behaviour (tensile strength.

  3. OPERATIONAL CIRCULAR No. 4 (REV. 1) – USE OF VEHICLES BELONGING TO OR RENTED BY CERN

    CERN Document Server

    2012-01-01

    Operational Circular No. 4 (Rev. 1) entitled “Use of vehicles belonging to or rented by CERN”, approved by the Director-general following discussion in the Standing Concertation Committee meeting of 15 February 2012, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 4 entitled “Conditions for use by members of the CERN personnel of vehicles belonging to or rented by CERN” of April 2003. This new version enables, in particular, to include CERN contractors and their personnel, to harmonize the structure of the circular with other circulars and to simplify the procedures by permitting electronics forms. Department Head Office HR Department

  4. Introduction Of Wavestar Wave Energy Converters At The Danish Offshore Wind Power Plant Horns Rev 2

    DEFF Research Database (Denmark)

    Marquis, L.; Kramer, Morten; Kringelum, J.

    is to be connected to a wind turbine at the DONG Energy owned wind power plant Horns Rev 2 placed off the western coast of Denmark. The plant delivers its energy production to a transformer station owned by Energinet.dk. Energinet.dk has the obligation to ensure that power is transmitted to the Danish consumers...... with this combination. This can increase the value of the produced power from future wind/wave plants. Further potential synergies of combining wind and wave energy in the same area include increased energy production from the available area and sharing of infrastructure costs as well as O&M facilities. In a future....... If Executed the project will be the first one in the world where wind and wave power are combined at full scale. The goal of the project is to evaluate the opportunities of combining wind and wave energy production on a commercial scale and to demonstrate the reduction of energy fluctuations...

  5. Hard bottom substate monitoring Horns Rev offshore wind farm 2004. Survey report no. 1

    Energy Technology Data Exchange (ETDEWEB)

    Frederiksen, Rune

    2004-05-15

    In connection with the implementation of the monitoring programme concerning the ecological implication of the effect of the introduction of hard substrate related to the Horns Rev Wind Farm, the third survey was carried out in the period 2431 March 2004. The survey covered collection of fauna and flora samples from the scour protection and at the wind turbine towers at six turbine sites. Video recordings were planned at different sites to provide documentation, but due to poor visibility the video recordings were postponed. On request from Elsam Engineering A/S video inspections on technical installations were made at turbine '84 and 95. This report covers a short description of the methodology, sampling activities and site description. (au)

  6. Révision systématique des Hipparion sensu lato (Perissodactyla, Equidae de l'Ancien Monde

    Directory of Open Access Journals (Sweden)

    Zouhri, S.

    2005-04-01

    Full Text Available La systématique des Hipparion sensu lato de l’Ancien Monde se caractérise par un foisonnement anormal des espèces rapportées à ce groupe et par une vive controverse sur le statut supraspécifique de celles-ci d’où une confusion générale de la phylogénie de ce groupe et bien évidemment des interprétations biochronologiques et biogéographiques qui en découlent. L’analyse critique de la systématique de chacune de ces nombreuses espèces d’Hipparion [s. l.] a permis une discussion et une réévaluation de la validité de ces dernières et la suggestion de synonymies et de regroupements de certaines espèces et l’élaboration d’une nouvelle classification supraspécifique de ce groupe. Quatre genres ont été alors redéfinis : Hippotherium, Hipparion, Cremohipparion et Proboscidipparion. Ce dernier taxon est subdivisé en trois sous-genres : Proboscidipparion, Plesiohipparion et Eurygnathohippus.La sistemática de Hipparion sensu lato del Antiguo Mundo se caracteriza por una multiplicación excesiva de especies relacionadas con este grupo y una marcada controversia sobre el status supraespecífico que trae consigo una confusión general de su filogenia, así como de las interpretaciones biocronológicas y biogeográficas que se deducen. El análisis crítico de la sistemática de cada una de las numerosas especies de Hipparion [s. l.] del Antiguo Mundo ha permitido una discusión y una reevaluación de la validez de las mismas, así como una nueva clasificación supraespecífica de este grupo. Cuatro géneros han sido redefinidos: Hippotherium, Hipparion, Cremohipparion y Proboscidipparion. Este último taxon ha sido subdividido en tres subgéneros: Proboscidipparion, Plesiohipparion y Eurygnathohippus. La validez, las sinonimias y los reagrupamientos de las especies relacionadas con cada uno de estos taxones han sido discutidos y analizados en detalle.

  7. Films minces d'oxycarbonates préparés par ablation laser pulsé : du système monocible au système multicible

    Science.gov (United States)

    Prellier, W.; Mercey, B.; Allen, J. L.; Tebano, A.; Hamet, J. F.; Hervieu, M.; Raveau, B.

    1998-01-01

    The microstructural study of superconductor thin films with general formula: (CaCuO_2)_m(Ba_2CuO_2CO_3)_n, grown from a single target, has shown that these films exhibited numerous intergrowth phases. Such films can not be used for precise physical studies. To obtain a regular stacking along a growth direction perpendicular to the substrate a multi-target system has to be used. The preliminary results of this study are presented herein. L'étude microstructurale des films minces supraconducteurs de formule générale : (CaCuO_2)_m(Ba_2CuO_2CO_3)_n, déposés à partir d'une seule cible, a montré qu'ils sont formés de nombreuses intercroissances. Ceci les rend pratiquement inutilisables pour des caractérisations physiques fines. Dans cet article sont présentées les étapes de la mise en oeuvre du système multicible nécessaire à la croissance d'un empilement régulier.

  8. Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors

    International Nuclear Information System (INIS)

    Kiss, A.; Li, L.; Gettemeier, T.; Venkatesh, L.K.

    2003-01-01

    Human immunodeficiency virus type 1 (HIV-1) Rev-mediated nuclear export of viral RNAs involves the interaction of its leucine-rich nuclear export sequence (NES) with nuclear cofactors. In yeast two-hybrid screens of a human lymph node derived cDNA expression library, we identified the human nucleoporin Nup98 as a highly specific and potent interactor of the Rev NES. Using an extensive panel of nuclear export positive and negative mutants of the functionally homologous NESs of the HIV-1 Rev, human T cell leukemia virus type 1 (HTLV-1) Rex, and equine infectious anemia virus (EIAV) Rev proteins, physiologically significant interaction of hNup98 with the various NESs was demonstrated. Missense mutations in the yeast nuclear export factor Crm1p that abrogated Rev NES interaction with the XXFG repeat-containing nucleoporin, Rab/hRIP, had minimal effects on the interaction of GLFG repeat-containing hNup98. Functional analysis of Nup98 domains required for nuclear localization demonstrated that the entire ORF was required for efficient incorporation into the nuclear envelope. A putative nuclear localization signal was identified downstream of the GLFG repeat region. Whereas overexpression of both full-length Nup98 and the amino-terminal GLFG repeat region, but not the unique carboxy-terminal region, induced significant suppression of HIV unspliced RNA export, lower levels of exogenous Nup98 expression resulted in a relatively modest increase in unspliced RNA export. These results suggest a physiological role for hNup98 in modulating Rev-dependent RNA export during HIV infection

  9. A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity.

    Science.gov (United States)

    Boons, Eline; Li, Guangdi; Vanstreels, Els; Vercruysse, Thomas; Pannecouque, Christophe; Vandamme, Anne-Mieke; Daelemans, Dirk

    2014-12-01

    The HIV Rev protein mediates the transport of partially and unspliced HIV mRNA from the nucleus to the cytoplasm. Rev multimerizes on a secondary stem-loop structure present in the viral intron-containing mRNA species and recruits the cellular karyopherin CRM1 to export viral mRNAs from the nucleus to the cytoplasm. Previously we have identified a single-domain intrabody (Nb(190)), derived from a llama heavy-chain antibody, which efficiently inhibits Rev multimerization and suppresses the production of infectious virus. We recently mapped the epitope of this nanobody and demonstrated that Rev residues K20 and Y23 are crucial for interaction while residues V16, H53 and L60 are important to a lesser extent. Here, we generated cell lines stably expressing Nb(190) and assessed the capacity of these cell lines to suppress the replication of different HIV-1 subtypes. These cells stably expressing the single-domain antibody are protected from virus-induced cytopathogenic effect even in the context of high multiplicity of infection. In addition, the replication of different subtypes of group M and one strain of group O is significantly suppressed in these cell lines. Next, we analysed the natural variations of Rev amino acids in sequence samples from HIV-1 infected patients worldwide and assessed the effect of Nb(190) on the most prevalent polymorphisms occurring at the key epitope positions (K20 and Y23) in Rev. We found that Nb(190) was able to suppress the function of these Rev variants except for the K20N mutant, which was present in only 0.7% of HIV-1 sequence populations (n = 4632). Cells stably expressing the single-domain intrabody Nb(190) are protected against virus-induced cytopathogenic effect and display a selective survival advantage upon infection. In addition, Nb(190) suppresses the replication of a wide range of different HIV-1 subtypes. Large-scale sequence analysis reveals that the Nb(190) epitope positions in Rev are well conserved across major HIV-1

  10. Administrative circular No. 2 (Rev. 5) – Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Document Server

    HR Department

    2011-01-01

    Administrative Circular No. 2 (Rev. 5) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 1 September 2011, is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 2 (Rev. 4) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" of September 2009. Department Head Office

  11. Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

    Directory of Open Access Journals (Sweden)

    Wesselingh Steven L

    2007-07-01

    Full Text Available Abstract Background The Sydney blood bank cohort (SBBC of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1. Although the cohort members have experienced differing clinical courses and now comprise slow progressors (SP as well as long-term nonprogressors (LTNP, longitudinal analysis of nef/long-terminal repeat (LTR sequences demonstrated convergent nef/LTR sequence evolution in SBBC SP and LTNP. Thus, the in vivo pathogenicity of attenuated HIV-1 strains harboured by SBBC members is dictated by factors other than nef/LTR. Therefore, to determine whether defects in other viral genes contribute to attenuation of these HIV-1 strains, we characterized dominant HIV-1 rev alleles that persisted in 4 SBBC subjects; C18, C64, C98 and D36. Results The ability of Rev derived from D36 and C64 to bind the Rev responsive element (RRE in RNA binding assays was reduced by approximately 90% compared to Rev derived from HIV-1NL4-3, C18 or C98. D36 Rev also had a 50–60% reduction in ability to express Rev-dependent reporter constructs in mammalian cells. In contrast, C64 Rev had only marginally decreased Rev function despite attenuated RRE binding. In D36 and C64, attenuated RRE binding was associated with rare amino acid changes at 3 highly conserved residues; Gln to Pro at position 74 immediately N-terminal to the Rev activation domain, and Val to Leu and Ser to Pro at positions 104 and 106 at the Rev C-terminus, respectively. In D36, reduced Rev function was mapped to an unusual 13 amino acid extension at the Rev C-terminus. Conclusion These findings provide new genetic and mechanistic insights important for Rev function, and suggest that Rev function, not Rev/RRE binding may be rate limiting for HIV-1 replication. In addition, attenuated rev alleles may contribute to viral attenuation and long-term survival of HIV-1 infection in a subset of SBBC members.

  12. Analysis of translesion DNA synthesis activity of the human REV1 protein, which is a key player in radiation-induced mutagenesis

    International Nuclear Information System (INIS)

    Masuda, Yuji; Kamiya, Kenji

    2003-01-01

    Ionizing radiation frequently causes oxidative DNA damage in cells. It has been suggested that functions of the REV1 gene are induction of mutations and prevention of cell death caused by ionizing radiation through the damage bypass DNA replication. The gene product possesses a deoxycytidyl transferase activity, which is required for translesion DNA synthesis of a variety of damaged bases and an abasic site. To elucidate molecular mechanisms of the mutagenesis and translesion DNA synthesis, it is important to characterize the enzymatic properties of the REV1 protein. Here, we describe a novel method for purifying the recombinant human REV1 protein and the anzymatic properties of the protein. We established an efficient system for induction of the recombinant human REV1 protein in Escherichia coli cells. The REV1 protein was purified to homogeneity using nickel-chelating sepharose, heparin sepharose and superdex 200 chromatography. When purified by this method, REV1 protein is free of endo-, exonuclease and DNA polymerase activities. The purified REV1 protein is suitable for enzymological studies, and we used this to biochemical characterization. The REV1 protein inserts dCMP opposite templates G, A, T, C and an abasic site and inserts dGMP and dTMP opposite template G. Kinetic analysis provided evidence for high efficiency for dCMP insertion opposite template G and an abasic site, suggesting that the REV1 protein play a role in translesion DNA synthesis of an abasic site. (author)

  13. Les pensions dans les pays de l'OCDE 2009 panorama des systèmes de retraite

    CERN Document Server

    Organisation for Economic Cooperation and Development. Paris

    2009-01-01

    Les politiques menées en matière de pensions et de retraite ont connu des évolutions considérables au cours des dernières années, les pouvoirs publics s’efforçant de concilier deux objectifs : assurer des revenus suffisants aux retraités et garantir la viabilité financière à long terme des systèmes de retraite face au vieillissement de la population. Panorama des Pensions 2009 propose un cadre de référence cohérent permettant de comparer les politiques adoptées dans ce domaine par les différents pays de l’OCDE, ainsi qu’un ensemble de données fiables. Cette troisième édition renferme des informations actualisées sur les principales caractéristiques des pensions versées au sein des pays de l’OCDE et contient des projections relatives aux revenus que percevront demain les salariés d’aujourd’hui. Elle offre également une gamme élargie d’indicateurs, parmi lesquels figurent des données chiffrées concernant les actifs, les performances des investissements, l’ampleur des ...

  14. Percepción local de los servicios ecológicos y de bienestar de la selva de la zona maya en Quintana Roo, México

    Directory of Open Access Journals (Sweden)

    Karla Diana Infante Ramírez

    2014-01-01

    Full Text Available Este estudio evalúa la percepción local sobre los servicios ecológicos y de bienestar de la selva en comunidades de la zona maya del centro de Quintana Roo. Se trabajó con seis unidades de paisaje, las cuales fueron delimitadas con la participación de habitantes de las comunidades y con una revisión de literatura. Para identificar los servicios que perciben las comunidades de la selva, se utilizaron entrevistas abiertas y semiestructuradas, observación participante, entrevistas a profundidad y talleres comunitarios. Los resultados muestran que los entrevistados identificaron servicios de provisión, de regulación y mantenimiento, y culturales. En particular, percibieron más servicios ecológicos en las unidades del “monte alto” y el “acahual de 20 años” o más, mientras que la “sabana” fue identificada como la que menos servicios les proporciona. Además, a partir de la teoría de los estudios de desarrollo, el estudio identifica las tres dimensiones del concepto de “bienestar humano”: la material, la relacional y la subjetiva, y logra presentar la relación de éstas con los servicios ecológicos percibidos por las comunidades estudiadas. Los resultados muestran una clara interacción sociedad maya-naturaleza y son útiles para orientar la toma de decisiones en el manejo de los recursos naturales, tanto a nivel comunitario como gubernamental.

  15. Determinación de la calidad ecológica del río Tuluá Valle del Cauca

    Directory of Open Access Journals (Sweden)

    César Augusto Bustamante Toro

    2014-12-01

    Full Text Available En el período comprendido entre febrero y junio de 2011, se realizó un estudio sobre la calidad ecológica del río Tuluá en sus tramos medio y bajo en la jurisdicción del municipio de Tuluá, Valle del Cauca. Se establecieron seis puntos de muestreo donde se colectaron macroinvertebrados acuáticos y se tomaron muestras de agua para los análisis físico-químicos y bacteriológicos. Para los resultados se aplicaron los índices de contaminación acuática (ICOMO, ICOMI e ICOSUS de Viña & Ramírez (1998, el índice biótico de calidad del agua BMWP adaptado por Zúñiga (2004 y los índices ecológicos de diversidad alfa y beta. También se determinó la composición y estructura del ensamble de macroinvertebrados encontrándose 1174 individuos distribuidos en 3 Phyllum, 4 Clases, 12 Órdenes, 25 Familias y 12 Géneros con valores de diversidad entre medios y bajo; en términos físico-químicos y ecológicos los tramos estudiados se encuentran en condiciones que varían entre aguas limpias y de buena calidad hasta aguas muy contaminadas. Es necesario que la autoridad ambiental y la sociedad civil del municipio de Tuluá formulen y apliquen estrategias de saneamiento para la prevención y control de la contaminación de esta importante corriente hídrica que es la principal fuente de abastecimiento de dicha localidad.

  16. Revisando a inserção ecológica: uma proposta de sistematização Revisiting the ecological engagement: a proposal to systematization

    Directory of Open Access Journals (Sweden)

    Laíssa Eschiletti Prati

    2008-01-01

    Full Text Available O presente artigo descreve como os quatro conceitos-chave da Teoria Bioecológica do Desenvolvimeno Humano (processo, pessoa, contexto e tempo se fazem presentes na metodologia denominada Inserção Ecológica. Tem o objetivo de proporcionar algumas linhas de ação que podem auxiliar equipes de pesquisa na utilização desta proposta em seus projetos de pesquisa. Para isso, foi realizada uma breve comparação entre a Inserção Ecológica e outras metodologias que valorizam o contexto da investigação, e que partem de referenciais teóricos diferentes. Além disso, são apresentados e discutidos estudos que utilizaram a Inserção Ecológia a fim de estabelecer alguns pontos em comum e definir aspectos que possam ser considerados características fundamentais a essa proposta metodológica.This article describes how the four key concepts of the Bioecological Theory of Human Development (process, person, context and time are present in the Ecological Engagement methodology. The goal is to provide some lines of action that may guide research teams to use this proposal in their projects. A brief comparison is performed between the Ecological Engagement and other methodologies, which value the concept of investigation and have distinct theoretical references. Moreover, other studies that used the Ecological Engagement are presented and discussed in order to establish some common points and to define aspects that may be considered as fundamental characteristics of this methodological proposal.

  17. Analyse de l'emballement thermique d'un système chimique hybride non tempéré

    OpenAIRE

    Véchot , Luc; Bigot , Jean-Pierre; Minko , Wilfried ,; Kazmierczak , Marc; Vicot , Patricia

    2009-01-01

    National audience; Ce travail s'intéresse au “blow-down” (emballement thermique en présence d'un évent de sécurité) d'un système chimique non tempéré (30% CHP) soumis à un incendie. Il utilise une maquette à l'échelle 0,1 l. L'analyse des données post décomposition a montré que la vapeur présente est principalement un produit de la réaction. Toutes les expériences de blow-down ont présenté deux pics de pression, quel que soit le rapport A/V, ce qui est typique des systèmes non tempérés. Nous ...

  18. Le Machine Learning confronté aux contraintes opérationnelles des systèmes de détection

    OpenAIRE

    Beaugnon , Anaël; Husson , Antoine

    2017-01-01

    International audience; Les systèmes de détection d’intrusion, reposant traditionnellementsur des signatures, n’ont pas échappé à l’attrait récent des techniquesde Machine Learning. Si les résultats présentés dans les articles de rechercheacadémique sont souvent excellents, les experts en sécurité ontcependant encore de nombreuses réticences concernant l’utilisation duMachine Learning dans les systèmes de détection d’intrusion. Ils redoutentgénéralement une inadéquation de ces techniques aux ...

  19. Intégration d'un système de Retour d'Expériences à un PLM

    OpenAIRE

    Bertin, Aurélie

    2012-01-01

    Les travaux présentés dans cette thèse s’inscrivent dans une problématique d’amélioration continue appliquée aux produits et aux processus industriels, par la mise en place d’un système de Retour d’Expérience (REx) couplé au système PLM (Product Lifecycle Management) de gestion du cycle de vie du produit. Les développements, menés dans le cadre d’un partenarial industriel, ciblent l’établissement d’une solution de valorisation du patrimoine immatériel de l’entreprise, constitué des expérience...

  20. Simulation numérique des transferts thermiques dans un système de séchage solaire du bois

    OpenAIRE

    Khouya , Ahmed; Benabdelouhab , Jaâfar; Draoui , Abdeslam

    2007-01-01

    International audience; Les auteurs présentent une étude théorique sur un système de séchage constitué d'un capteur solaire à air de type multi–passes muni d'ailettes et couplé à une cuve de stockage dans les conditions climatiques de la région de Tanger au Maroc. L'étude est réalisée à partir des modèles mathématiques obtenus par l'écriture des lois de conservation de l'énergie dans les différentes composantes du système. Des simulations ont été réalisées en exploitant des mesures expériment...

  1. Modélisation d'un système de séchage solaire du tabac en Algérie

    OpenAIRE

    Benaouda , Nour-Eddine; Belhamel , Maiouf

    2007-01-01

    International audience; L'étude a porté sur la contribution théorique du bilan d'énergie d'un système de séchage convectif des produits en feuilles. Dans ce travail, nous nous intéressons aux aspects énergétiques d'un système solaire de séchage. Le but visé par ce présent travail est l'étude de l'influence des différents paramètres entrant en jeu dans le séchage du tabac par voie solaire en Algérie.

  2. Techniques avancées du traitement d'antennes pour la localisation de sources : application à la localisation de mobile: cas du système UMTS.

    OpenAIRE

    Grosicki , Emmanuele

    2003-01-01

    La thèse a porté sur la localisation de mobile pour les systèmes UMTS-FDD. Il s'agit d'un sujet qui intéresse de plus en plus les opérateurs, notamment dans le cas de système UMTS-FDD où il existe très peu de réseaux réels. Les différentes approches permettant de localiser un émetteur ont ainsi été envisagées, et plus particulièrement, celles basées sur les mesures de puissances, les temps d'arrivée (TOA) en liaison descendante ou encore celles basées sur les angles d'arrivée (AOA) et sur tou...

  3. Le système d’information sur la biodiversité de l’administration des parcs nationaux argentins

    Directory of Open Access Journals (Sweden)

    Leonidas Lizarraga

    2014-06-01

    Full Text Available Introduction Le système d’information sur la biodiversité (SIB, Sistema de Información de Biodiversidad de l’administration des parcs nationaux argentins (APN, Administración de Parques Nacionales a été lancé en 2002, avec le soutien du Global Environment Fund (GEF dans le cadre du Projet de préservation de la biodiversité mené par l’État argentin. Le dispositif, abrégé en SIB-APN, est composé d’un ensemble de bases de données thématiques et d’un système d’information géographique : son ob...

  4. Optimisation du temps de réponse du système de recommandation pour l'évaluation MIMICRY

    OpenAIRE

    Follet , Damien; Delestre , Nicolas; Malandain , Nicolas; Vercouter , Laurent

    2015-01-01

    Conférence EIAH 2015; L'évaluation par grille d'évaluation est de plus en plus répandue. Elle facilite l'apprentissage des apprenants mais augmente la charge d'évaluation des enseignants. Nous proposons un système de recommandation pour l'évaluation par grille de compétences, utile, utilisable, thématiquement indépendant et basé sur l'apprentissage artificiel. Dans cet article nous testons ce système sur des données réelles pour des compétences non triviales. Nous identifions deux limites fon...

  5. La economía ecológica y las formas de propiedad del manglar de la zona norte de Esmeraldas

    OpenAIRE

    Rosales Estupiñan, Mauricio

    1995-01-01

    Hay dos problemas urgentes por resolver en la zona norte de Esmeraldas: La pobreza de las comunidades locales, y la conversión (destrucción) de los manglares a camaroneras y sus externalidades. En la zona norte de Esmeraldas se encuentra el sistema de manglar comprendido entre los ríos Mataje y los alrededores de la desembocadura del río Santiago, con un extensión aproximada de 50.000 ha. Los manglares son un sistema ecológico abierto que interactúa con el mar, los estuarios, los esteros y la...

  6. Metodología para determinar la huella ecológica de la construcción de edificios de uso residencial en España

    OpenAIRE

    Solís-Guzmán, Jaime

    2013-01-01

    La actividad constructora es en la actualidad una gran consumidora de recursos naturales. Para evaluar este consumo de recursos generalmente se han empleado metodologías relacionadas con el Análisis de Ciclo de Vida. Se plantea en esta comunicación la integración del indicador Huella Ecológica (HE) en el sector edificación, para observar las dificultades y las ventajas que puede generar respecto a otros indicadores. Para ello, se pretende adaptar los conocimientos previos relacionados con el ...

  7. La ficción en Internet para trasladar información de actualidad: ¿Diga?, un cortometraje sobre la huella ecológica

    OpenAIRE

    Velasco Manso, Marta

    2017-01-01

    ¿Diga? es un cortometraje de ficción que traslada información sobre hábitos de consumo responsable con el fin de mostrar su importancia en el medio ambiente y en concreto, en la reducción de la huella ecológica. El cortometraje se enmarca dentro de un proyecto digital, Episodio Piloto, una página web donde albergar producciones breves de ficción junto a información que se pretenda mostrar con ellas. La información ligada a ¿Diga? se traslada mediante un artículo sencillo que explica el concep...

  8. Las áreas naturales protegidas y la investigación ecológica de largo plazo en México

    OpenAIRE

    M. Maass; E. Jardel; A. Martínez-Yrízar; L. Calderón; J. Herrera; A. Castillo; J. Euán-Ávila; M. Equihua

    2010-01-01

    Detrás de la actual crisis ambiental está nuestra limitada comprensión de los procesos ecológicos y sociales que operan a escalas espaciotemporales amplias. Esta falta de conocimiento ha desencadenado fallos en los esquemas de manejo y utilización de los servicios y recursos que nos brindan los ecosistemas naturales, lo que a su vez ha provocado su deterioro a escalas globales. Una respuesta de la comunidad académica a este vacío del conocimiento ha sido la formación de grupos de científicos ...

  9. Las áreas naturales protegidas y la investigación ecológica de largo plazo en México

    OpenAIRE

    Maass Moreno, Manuel; Jardel Peláez, Enrique; Martínez Yrízar, Angelina; Calderón Aguilera, Luis; Herrera Silveira, Jorge; Castillo Álvarez, Alicia; Euán Ávila, Jorge; Equihua Zamora, Miguel

    2010-01-01

    Detrás de la actual crisis ambiental está nuestra limitada comprensión de los procesos ecológicos y sociales que operan a escalas espacio-temporales amplias. Esta falta de conocimiento ha desencadenado fallos en los esquemas de manejo y utilización de los servicios y recursos que nos brindan los ecosistemas naturales, lo que a su vez ha provocado su deterioro a escalas globales. Una respuesta de la comunidad académica a este vacío del conocimiento ha sido la formación de grupos de científicos...

  10. Ecoturismo en la reserva Cuyabeno : realidad y retórica en la relación de los Siona con el turismo ecológico 1994

    OpenAIRE

    Arrueta, José Antonio

    1996-01-01

    El Turismo es una actividad que consiste básicamente en visitar lugares en donde buscamos satisfacer demandas relacionadas a información, diversión, conocimiento y placer. El turismo ecológico implica reglamentos de conducta de los visitantes, en relación a la preservación y conservación de los sitios naturales a silvestres que se visita. Incluye la participación de las poblaciones locales de los sitos de reserva como “beneficiarias” del ecoturismo. Estos "principios generales" del turismo ec...

  11. Preocupación y conducta ecológica responsable en estudiantes universitarios: estudio comparativo entre estudiantes chilenos y españoles

    OpenAIRE

    Palavecinos, Mireya; Amérigo, María; Ulloa, Jorge B.; Muñoz, Jaime

    2016-01-01

    RESUMEN Se discutirán los resultados de un estudio piloto, que forma parte de un proyecto mayor, orientado al análisis transcultural de la preocupación ambiental y su relación con la conducta ecológica. El propósito de este artículo es mostrar los resultados obtenidos de la aplicación del instrumento creado en España para probarlo en la realidad chilena, donde no se contaba con un instrumento pertinente que evaluara estos factores a nivel local. El método contempla la comparación de los resul...

  12. El plan director de la vega baja de Toledo, España: paisaje patrimonial, ecológico y urbano.

    OpenAIRE

    Hernandez Aja, Agustin; Roch Peña, Fernando; Moran Alonso, Nerea; Fernandez Ramirez, Cristina

    2014-01-01

    La Vega Baja de Toledo constituye un gran vacío urbano que, por avatares históricos, se ha mantenido al margen del crecimiento de la ciudad, rodeada por el casco histórico de Toledo, los barrios del ensanche norte y el río Tajo. Su localización privilegiada, junto a la riqueza patrimonial y ecológica del espacio, han sido las bases de la propuesta del Plan Director de la Vega Baja (PDVB). El objetivo del PDVB ha sido articular este vacío y abrirlo a la población, a la vez que proteger y re...

  13. Diseño de un plan comunicacional para la industria de las curtiembres, basado en marketing ecológico

    OpenAIRE

    Rincón Alvarado, Mónica Lorena

    2012-01-01

    La trasformación y constante contaminación generada por las actuales empresas, ha generado un impacto en los consumidores que obliga a que las diferentes industrias apliquen cambios en sus actuales formas de producción, es por esto que a través del marketing ecológico se pretende implementar cambios que ayuden a que la industria de los cueros reduzca su actual impacto negativo en el medio ambiente. Facultad de Ciencias Económicas

  14. La huella ecológica y los países andinos, una reflexión sobre la sustentabilidad y la biocapacidad

    Directory of Open Access Journals (Sweden)

    Deyanira Gómez

    2013-09-01

    Full Text Available La escasez de los recursos ha llevado a la reflexión respecto a la medición del desarrollo, que ya no puede ser medido únicamente en términos de crecimiento económico como lo hace el Producto Interno Bruto (PIB, sino que es necesario tomar en cuenta los recursos o capital natural con los que cuenta una determinada nación para que desde una perspectiva de sustentabilidad, pueda asegurar la calidad de vida de las generaciones futuras, esta herramienta se la conoce como la Huella Ecológica.

  15. Estudio de las especies de pulgones y sus enemigos naturales en una finca de horticultura ecológica en Alcàsser, Valencia

    OpenAIRE

    JIMÉNEZ PÉREZ, IRENE

    2016-01-01

    En la finca donde se ha realizado este estudio, el principal problema de plagas en los cultivos son los pulgones. Debido a la importancia de estos insectos y la gravedad de los daños que producen, se plantea el siguiente TFC que tiene como objetivos: 1. Identificar las diferentes especies de pulgón que podemos encontrar en determinadas plantas hortícolas a lo largo de un periodo de 6 meses en un cultivo ecológico en el municipio de Alcàsser, Valencia. 2. Determinar la densidad de poblac...

  16. Determinación de la Huella de Carbono de productos agrícolas en una finca de agricultura ecológica

    OpenAIRE

    ROIG BENEDITO, MIGUEL

    2017-01-01

    [ES] La necesidad de paliar el cambio climático hace necesario reducir las emisiones absolutas en todos los sectores, incluso en la agricultura. La determinación de la Huella de Carbono en los productos permite estimar las emisiones de GEI (Gases de Efecto Invernadero) durante el ciclo de vida de los productos agrícolas. El objetivo del presente trabajo es identificar los distintos gases de efecto invernadero que se producen en una explotación de agricultura ecológica. Para ello s...

  17. Impacto ecológico de los Intercambiadores de calor de tubo y coraza; Ecological impact of Shell and tube heat exchangers

    Directory of Open Access Journals (Sweden)

    Maida Bárbara Reyes Rodríguez

    2015-04-01

    Full Text Available Los intercambiadores de calor de tubo y coraza son de los equipos más importantes en la industria. Su diseño termodinámico se basa en el coeficiente global de transferencia de calor y la caída de presión total. En 2007 se estableció una nueva propiedad termodinámica denominada “Entransía”, que expresa la capacidad de un cuerpo de transferir calor. A la pérdida de esa capacidad se le denomina “Disipación de Entransía”. Para evaluar el impacto ecológico de las máquinas térmicas, Angulo-Brown creó en 1991 la llamada función ecológica. En el presente trabajo se combinó la disipación de entransía con la función ecológica y se creó una nueva expresión para evaluar el impacto ambiental de los intercambiadores de calor. Se realizó además la optimización muti-objetivo de estos equipos. Fueron utilizadas como funciones objetivo la función ecológica y el costo. Para realizar la optimización se utilizó el método de los Algoritmos Genéticos.Shell and tube heat exchangers are ones the most important equipment in the industry. Their thermodynamic design is based on the global heat transference coefficient and the pressure drop. In 2007 was settled a new thermodynamic property denominated “Entransy”, which expresses the capacity of a body to transfer heat. The loss of this capacity is denominated “Entransy Dissipation”. For evaluating the ecological impact of thermal machines, Angulo-Brown created in 1991 the “ecological function”. In this paper the“entransy dissipation” and the ecological function were combined and a new expression for evaluating the ecological impact of shell and tube heat exchangers was created. A multi-objective optimization of this equipment wasalso realized. The ecological function and the cost wereused as objective functions. For carry out the optimization the method of the Genetic Algorithms was used.

  18. Estudios florísticos y ecológicos sobre las algas de agua dulce de turberas de Tierra del Fuego

    OpenAIRE

    Mataloni, María Gabriela

    1994-01-01

    En esta Tesis Doctoral se realizan diversas investigaciones florísticas y ecológicas sobre las algas de turberas de Sphagnum de la provincia de Tierra Fuego. Para ello se condijeron básicamente dos trabajos. en la primera parte se estudiaron ocho ojos de agua pertenecientes a siete turberas ubicadas en el sur de Tierra del Fuego. En cada una de ellas se muestrearon tanto el fitoplancton del agua libre como las algas que viven asociadas a Sphagnum a lo largo de un gradiente ambiental caracteri...

  19. Introducción a la Huella Ecológica. Aplicación al análisis de Sistemas agroganaderos

    OpenAIRE

    David Pérez Neira; Marta Soler Montiel

    2012-01-01

    La Huella Ecológica puede ser definida como un indicador biofísico que integra el conjunto de impactos que ejerce una comunidad sobre su entorno medido en términos de apropiación de ecosistemas -considerando tanto los recursos necesarios como los residuos generados para el mantenimiento de dicha comunidad. En los últimos años, en la literatura académica esta herramienta también se ha venido utilizando como indicador que mide de impacto asociado a productos, servicios o actividades económicas....

  20. Systèmes turbiditiques calcaires du Tithonien et du Barrémo-Bédoulien subalpins (SE de la France) (1-3 septembre 2005)

    OpenAIRE

    Ferry , Serge; Atrops , François; Backert , Nicolas; Lozano-Garcia , F.; Savary , Bérangère

    2005-01-01

    International audience; Les systèmes turbiditiques calcaires sont encore peu étudiés par rapport à leurs homologues silico-clastiques, bien que la notion de “calcaires allodapiques” soit à peu près aussi ancienne que la notion de turbidite. Une typologie des appareils calcaires (faciès, géométries, rapports avec les plates-formes carbonatées nourricières) reste à faire.

  1. Výběr volebního systému v kontextu demokratické tranzice a konsolidace

    OpenAIRE

    Maděra, Milan

    2017-01-01

    Electoral System Choice in the Context of the Democratic Transition and Consolidation Diploma thesis examines the influence of exogenous factors on motivation and preferences of electoral reform actors based on their power position and value-driven approach in Czechoslovakia. It deals with the relation among mode of transition, the electoral reform type and the electoral system type as outcome for the founding elections. It attempts to identify the difference of conditions for electoral syste...

  2. Activité antérieure – Améliorer la recherche sur les systèmes de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 avr. 2016 ... M. Félix Boa Yapo, directeur général de la santé de la Côte d'Ivoire, a ouvert la séance de consultation, en compagnie de Stanislas Kambour, directeur des systèmes de recherche et de renseignements sur la santé de l'OOAS, et de Chantal de Varennes, ambassadrice du Canada auprès de la République ...

  3. Analýza reportingového informačního systému ve skupině GE Money ČR

    OpenAIRE

    Greif, Tomáš

    2006-01-01

    Popis prvků informačních systémů ve společnosti. Vliv IS na manažerskou práci. Obecné projektové řízení a nástin metod řešení a vizualizace. Východiska a postup aplikace metodiky BPMS. Aplikace metodiky BPMS v organizaci. Implementace reportingové technologie.

  4. Développement d’un système de contrôle, de configuration et de supervision graphique distribué

    CERN Document Server

    Moreau, Alexandre

    2005-01-01

    Dans le cadre de l’expérience LHCb, les physiciens travaillant au CERN devront acquérir et analyser un nombre considérable d’informations issues des différents d´etecteurs. Afin de les obtenir, un important dispositif d’acquisition de données a été élaboré au sein même du CERN, comprenant des centaines de cartes électroniques, qui permettront non seulement de s’assurer du bon déroulement de l’expérience, mais également de véhiculer ces données depuis les détecteurs jusqu’aux zones de stockage. La configuration, le contrôle et la surveillance de ces cartes devront être faits à distance, grâce à un logiciel de type SCADA, sous la forme d’interfaces graphiques. Mon travail a donc consisté à réaliser ce système pour un type bien précis de cartes électroniques équipées d’un PC embarqué. Le système réalisé répond maintenant à la plupart des attentes, mais existant des systèmes équivalents pour d’autres types de cartes électroniques, il est maintenant envisag...

  5. Informační systém pro správu rezervací v restauracích

    OpenAIRE

    Slanař, David

    2009-01-01

    Tato bakalářská práce pojednává o stávajícím stavu fungování rezervací v restauracích a jeho inovaci pomocí zavedení informačního systému pro vytváření a správu rezervací. Popisuje návrh internetové webové aplikace umožňující on-line vytváření rezervací samotnými uživateli a jejich následnou správu zaměstnanci. Dále popis ekonomického přínosu a jiných výhod plynoucích ze zavedení tohoto systému v reálném světě a v neposlední řadě řešení případných problémů při nasazování systému v praxi. T...

  6. OPERATIONAL CIRCULAR NO2 (REV. 1) - APRIL 1998 'CONDITIONS OF ACCESS TO THE FENCED PARTS OF THE CERN SITE'

    CERN Multimedia

    Human Resources Division

    2001-01-01

    Subsidiary document 'Implementation Measures' (Rev. 2) - April 2001 The subsidiary document has been amended. Copies are available from Divisional Secretariats and at CERN card issue points. Note : Administrative and operational circulars, as well as the lists of those in force, are available for consultation on WWW : ADMINISTRATIVE CIRCULARS OPERATIONAL CIRCULARS

  7. 78 FR 27971 - Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not...

    Science.gov (United States)

    2013-05-13

    ...] Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not Withdrawn From Sale... ophthalmic solution), 0.5%, was not withdrawn from sale for reasons of safety or effectiveness. This... ophthalmic solution, 0.5%, if all other legal and regulatory requirements are met. FOR FURTHER INFORMATION...

  8. Finanšu pārskata revīzijas process lielai sabiedrībai

    OpenAIRE

    Špoģe, Sarmīte

    2018-01-01

    Finanšu pārskata revīzijas process ir svarīgs temats, jo pirmreizēji revidētiem uzņēmumiem tiek atklātas būtiskas neatbilstības grāmatvedības uzskaitē, tās atbilstībai LR likumiem un normatīvajiem aktiem, kā arī finanšu pārskata sagatavošanā. Darba mērķis: apkopot un analizēt finanšu pārskata revīzijas procesu lielā sabiedrībā, noteikt revīzijas riskus, izstrādāt priekšlikumus revīzijas procesa uzlabošanai. Izvirzīto mērķu sasniegšanai autore pētīja un apkopoja informāciju par finanšu pārska...

  9. Upper Bound Radiation Dose Assessment for Military Personnel at McMurdo Station, Antarctica, between 1962 and 1979 (2REV)

    Science.gov (United States)

    2017-09-30

    N IC A L R EP O R T Defense Threat Reduction Agency 8725 John J. Kingman Road , MS-6201 Fort Belvoir, VA 22060-6201 STANDARD FORM 298 (Rev. 8/98...8725 John J. Kingman Road , Mail Stop 6201 Fort...Early Operation ..................................................................................... 5 2.2 Operations and Maintenance

  10. Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    DEFF Research Database (Denmark)

    Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth

    2017-01-01

    (ADP) ribose polymerase 1 (PARP1) activity, low endogenous NAD+, low expression of SIRT1 and PGC1α and low adenosine monophosphate (AMP)-activated kinase (AMPK) activity. We conclude that replication stress via Rev1-deficiency contributes to metabolic stress caused by compromized mitochondrial function via...... the PARP-NAD+-SIRT1-PGC1α axis....

  11. Reliability of Concentric, Eccentric and Isometric Knee Extension and Flexion when using the REV9000 Isokinetic Dynamometer

    DEFF Research Database (Denmark)

    de Carvalho Froufe Andrade, Alberto César Pereira; Caserotti, Paolo; de Carvalho, Carlos Manuel Pereira

    2013-01-01

    The aim of this study was to assess the reliability of isokinetic and ISO knee extensor and flexor muscle strength when using the REV9000 (Technogym) isokinetic dynamometer. Moreover, the reliability of several strength imbalance indices and bilateral ratios were also examined. Twenty-four physic...

  12. A Comprehensive Experiment for Molecular Biology: Determination of Single Nucleotide Polymorphism in Human REV3 Gene Using PCR-RFLP

    Science.gov (United States)

    Zhang, Xu; Shao, Meng; Gao, Lu; Zhao, Yuanyuan; Sun, Zixuan; Zhou, Liping; Yan, Yongmin; Shao, Qixiang; Xu, Wenrong; Qian, Hui

    2017-01-01

    Laboratory exercise is helpful for medical students to understand the basic principles of molecular biology and to learn about the practical applications of molecular biology. We have designed a lab course on molecular biology about the determination of single nucleotide polymorphism (SNP) in human REV3 gene, the product of which is a subunit of…

  13. The calculational VVER burnup Credit Benchmark No.3 results with the ENDF/B-VI rev.5 (1999)

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Gual, Maritza [Centro de Tecnologia Nuclear, La Habana (Cuba). E-mail: mrgual@ctn.isctn.edu.cu

    2000-07-01

    The purpose of this papers to present the results of CB3 phase of the VVER calculational benchmark with the recent evaluated nuclear data library ENDF/B-VI Rev.5 (1999). This results are compared with the obtained from the other participants in the calculations (Czech Republic, Finland, Hungary, Slovaquia, Spain and the United Kingdom). The phase (CB3) of the VVER calculation benchmark is similar to the Phase II-A of the OECD/NEA/INSC BUC Working Group benchmark for PWR. The cases without burnup profile (BP) were performed with the WIMS/D-4 code. The rest of the cases have been carried with DOTIII discrete ordinates code. The neutron library used was the ENDF/B-VI rev. 5 (1999). The WIMS/D-4 (69 groups) is used to collapse cross sections from the ENDF/B-VI Rev. 5 (1999) to 36 groups working library for 2-D calculations. This work also comprises the results of CB1 (obtained with ENDF/B-VI rev. 5 (1999), too) and CB3 for cases with Burnup of 30 MWd/TU and cooling time of 1 and 5 years and for case with Burnup of 40 MWd/TU and cooling time of 1 year. (author)

  14. Epitopes of human immunodeficiency virus regulatory proteins tat, nef, and rev are expressed in normal human tissue

    NARCIS (Netherlands)

    Parmentier, H. K.; van Wichen, D. F.; Meyling, F. H.; Goudsmit, J.; Schuurman, H. J.

    1992-01-01

    The expression of regulatory proteins tat, rev, and nef of human immunodeficiency virus type-1 (HIV-1) and tat of HIV-2 was studied in frozen sections of lymph nodes from HIV-1-infected individuals, and various tissues from uninfected persons. In HIV-1-positive lymph nodes, monoclonal antibodies to

  15. Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

    Science.gov (United States)

    Vincendeau, Michelle; Kramer, Susanne; Hadian, Kamyar; Rothenaigner, Ina; Bell, Jeanne; Hauck, Stefanie M; Bickel, Christian; Nagel, Daniel; Kremmer, Elisabeth; Werner, Thomas; Leib-Mösch, Christine; Brack-Werner, Ruth

    2010-10-23

    In human astrocytes, restriction of HIV replication involves inhibition of HIV Rev activity. We previously identified a Rev-interacting human protein fragment (16.4.1) that can reduce Rev activity. The 16.4.1 sequence is contained in a group of highly similar host cell proteins, which we call the Risp family. Here we investigate whether the Risp family is connected to HIV replication in astrocytes. Cell/tissue lysates were analyzed for Risp expression by western blot with various anti-Risp antibodies. The interaction of astrocytic Risp members with Rev was investigated by affinity chromatography. Astrocytes were transfected with expression plasmids containing cDNAs encoding full-length Risp or the isolated 16.4.1 region for Risp overexpression or with siRNAs designed for Risp knock-down. Rev activity was investigated with a Rev-reporter assay. RNA levels were quantified by real-time RT-PCR, HIV Gag levels by p24ELISA. Expression of the Risp family was demonstrated in human brain tissues and astrocytes. Astrocytes were shown to produce Risp family members that interact with Rev. Production of HIV Gag proteins and Rev-dependent RNAs in persistently infected astrocytes increased upon Risp knock-down and decreased upon Risp overexpression. Risp knock-down increased Rev activity and raised proportions of Rev proteins in the nucleus of astrocytes. Our results link the Risp family to restriction of HIV production and inhibition of Rev activity in astrocytes. We conclude that the Risp family represents a novel family of host factors that can control HIV replication and may be important for the containment of HIV infection in brain reservoirs.

  16. Study on the REV Size of Fractured Rock in the Non-Darcy Flow Based on the Dual-Porosity Model

    Directory of Open Access Journals (Sweden)

    Yuan Wang

    2018-01-01

    Full Text Available For the problem of whether the representative elementary volume (REV obtained in the Darcy flow is also applicable to the case of the non-Darcy flow, the study on the REV size within the non-Darcy flow is proposed tentatively. The concept of the REV in the non-Darcy flow is based on the definition of the REV. According to the determination of the REV in the Darcy flow, the intrinsic permeability k and non-Darcy coefficient β are used simultaneously for the determination of the REV in the non-Darcy flow. The pore pressure cohesive element (PPCE is developed with the subroutine in ABAQUS. Then the simulation method of the Darcy and non-Darcy flow in the fractured rock mass is built using the PPCE. The proposed plan is examined through the comparison with existing research results. It is validated that this technic is efficient and accurate in simulating the Darcy and non-Darcy flow in the fractured rock mass. Combined with fracture networks generated by Monte Carlo Simulation technique, the PPCE is applied to the study on the REV size. Both conditions of the Darcy and non-Darcy flow are simulated for comparison. The simulation results of this model show that the REV of the non-Darcy flow is inconsistent with the REV of the Darcy flow, and the REV of the non-Darcy flow is more significant than the REV of the Darcy flow. The intrinsic permeability k tensors obtained in the Darcy flow and the non-Darcy flow are basically the same.

  17. Determinantes de la transmisión de dengue en Veracruz: un abordaje ecológico para su control

    Directory of Open Access Journals (Sweden)

    Escobar-Mesa Javier

    2003-01-01

    Full Text Available OBJETIVO: Identificar los factores ambientales, sociales y demográficos que contribuyen a explicar las diferencias en la transmisión de dengue en Veracruz, México, durante el periodo 1995-1998 y definir las áreas de riesgo para promover un mejor control del problema. MATERIAL Y MÉTODOS: Bajo un diseño ecológico se analizó una base de datos con el número de casos de dengue que se presentaron en 1 249 localidades en las 11 Jurisdicciones Sanitarias del estado de Veracruz durante el periodo 1995-1998. Cada una de las localidades fue identificada de acuerdo con su altitud, latitud y longitud, y con el número total de la población por sexo, el número de viviendas y la dotación de servicios públicos. Se tomó también el índice de marginación por localidad del Consejo Nacional de Población. RESULTADOS: El dengue en Veracruz se registró en 17% de las localidades y en sólo 6% de ellas se concentraron 70% de los casos de dengue en el estado. Las localidades repetidoras de dengue fueron grandes centros urbanos, con baja marginación y extensa dotación de servicios públicos. El dengue sí se transmite en las áreas rurales del estado aunque la transmisión es ocasional. El promedio de casos de dengue reportados en las localidades dependió del tamaño de la misma y del número de años que reportaron dengue durante el periodo. Se reporta un umbral poblacional para la transmisión. CONCLUSIONES: Se identificaron las localidades repetidoras de dengue que concentran 70% de los casos, y las determinantes sociales y ambientales de la transmisión. Este enfoque de riesgo puede mejorar el control y tener un impacto significativo en la prevención de la transmisión en las zonas de mayor riesgo.

  18. Linajes fantasma y correlación con variables ecológicas: el caso de la Subfamilia Caprinae

    Directory of Open Access Journals (Sweden)

    Morales, J.

    2006-12-01

    Full Text Available Integration between systematic phylogenetics and palaeontological data has been probed to be an effective methodology to value palaeodiversities because it identifies periods in the evolutionary history of the clade without fossil representation. These are called ghost lineages. In this work we explore the possible relationship of ghost lineages duration with biometric, biogeografic or ecological variables in the Subfamily Caprinae (Bovidae, Mammalia. Variables were codified as binary characters and their relationship was examined using the concentrated-changes test. Our results indicate that species appearing in rainforest, warm temperate forest, taiga and desert biomes are related with high proportion of ghost lineages, while those from steppe biome present lower proportions. Zones inhabited by species of Caprinae in rainforest, warm temperate forest, taiga and desert are usually associated with high altitudes and a steep topography. Thus, we interpret that proportions in ghost lineages would be determined by probabilities of sedimentation and fossil site development .La integración de la sistemática filogenética con datos paleontológicos ha demostrado ser una eficaz metodología a la hora de estimar paleodiversidades mediante la identificación de periodos en la historia evolutiva de los clados sin representantes fósiles, a los que se denominan linajes fantasma. En este trabajo pretendemos estudiar la posible correlación con variables biométricas, biogeográficas o ecológicas con el fin de averiguar si la duración de los linajes fantasma puede ser relacionada con este tipo de variables. Este estudio está basado en la Subfamilia Caprinae (Bovidae, Mammalia. Las variables estudiadas fueron traducidas a caracteres binarios y se analizó su correlación mediante análisis de cambios concentrados. Nuestros resultados indican que las especies que aparecen en los biomas pluvisilva, laurisilva, taiga y desierto están ligadas a altos

  19. The effects of cynodon dactylon on the immune response of NMRI-MICE after challenge with REV1

    Directory of Open Access Journals (Sweden)

    Behrooz Ilkhanizadeh

    2016-10-01

    Full Text Available Cynodon dactylon is used in Iranian traditional medicine as a healing agent for reducing the complications of diabetes mellitus. We proposed that Cynodon dactylon may perform its effects through moderating humoral and cellular immune responses. We aimed to determine the possible effects of hydroalcholic extract of Cynodon dactylonon humoral and cellular immune responses following the Rev1 challenge in the mouse model. 20 NMRI male mice were randomly grouped in two equal groups and immunized with Rev1[0.1 ml Rev1+0.9 PBS[. Mice in the treatment group orally received 400 mg/kg hydroalcoholic extract of Cynodon dactylon every day from the beginning of the study for 2 weeks. Blood samples were obtained from the animals 5 days after the last injection. Moreover, 48 hr before bleeding time, Rev1[0.1 ml Rev1+0.9 PBS[was injected into the left hind foot pad of mice. The levels of anti-Rev1 antibody and the specific cellular immune responses were measured by microhemagglutination test and footpad thickness, respectively. Moreover, susceptibility of macrophages respiratory burst and proliferation of immune cells were measured in order withNitroblue tetrazolium[NBT] and Microculture Tetrazolium Assay [MTT]. The concentrations of IL-1, TNFα, Il-6, and IL-10 in the serum were determined using commercially available ELISA kits. We found a significant increase in anti-Rev1 antibody levels and simultaneously a significant decrease in the level of cellular immunity[DTH] in the treatment group compared to the control group. Lymphocyte proliferation index in splenocytes was significantly increased in the treatment group. However, the level of respiratory burst in phagocytic population of splenocytes dramatically decreased in the treatment group compared to the control. A significant decrease in IL-6, TNF-α , IL-1 and increaseIl-10 serum levels were also seen in the treatment group. Cynodon dactylon extract could have an anti-inflammatory effect through

  20. Indemnisation des dommages résultant de soins de santé. Phase V : impact budgétaire de la transposition du système français en Belgique

    OpenAIRE

    Yerna, Benoît-Laurent; Maréchal, Xavier; Denuit, Michel; Closon, Jean-Pierre; Vinck, Imgard

    2009-01-01

    L’objectif de la présente étude consiste, d’une part, à décrire le système français d’indemnisation des victimes de dommages médicaux et, d’autre part, à calculer l’impact budgétaire de la transposition d’un tel système en Belgique. Les spécificités du système qui sera introduit en Belgique n’étant pas connues au moment de l’étude, le coût a été calculé sur la base des modalités du système en vigueur en France. Les statistiques françaises de fréquences des différents types de dommages (infect...

  1. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2003

    International Nuclear Information System (INIS)

    Bech, M.; Leonhars, S.B.; Pedersen, John

    2004-05-01

    ELSAM and ELTRA have established an offshore wind farm with an output of 160 MW in the waters of Horns Rev 1420 km off Blaevands Huk, which is the most westerly point of Denmark. The first phase of construction of the wind farm started in spring 2002. Before the construction activities took place, a baseline description of the benthos was conducted as a part of an environmental monitoring programme for the establishment of the Horns Rev Offshore Wind Farm. The baseline surveys for the present monitoring programme were conducted in the wind farm area on three occasions: spring 1999, spring 2001 and September 2001. In designated reference areas, surveys were conducted in spring 1999 and September 2001. The reference areas in 1999 and September 2001 were placed at two different geographical locations because the survey in September 2001 was planned to be a part of a fish monitoring programme. A comparison between the baseline study in spring 2001 and the baseline study in autumn 2001 clearly revealed that the biomass of most species increased considerably from spring to September. Despite the increase in biomass, the overall distribution of the species and their relative abundance did not change. In order to use the baseline data to investigate a possible impact after the construction of the wind farm, it was essential to arrange the monitoring programme either in spring or in September 2003, because the baseline studies were conducted in these periods. The monitoring programme was conducted in September 2003 after the wind farm had become operational, parallel with the survey on hard bottom substrates. The impacts of the wind farm on the benthic fauna (infauna) in the area were mainly expected to be due to the alteration of the local currents. As the changes in the currents are only minor, impacts on the water chemistry and on the benthic fauna resulting from hydrodynamic causes were expected to be limited or non-existent. The main objective of the present monitoring

  2. Infauna monitoring Horns Rev offshore wind farm. Annual state report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Bech, M.; Frederiksen, R.; Pedersen, John; Leonhard, S.B.

    2005-04-15

    A total of 40 species were identified from the surveys in the Horns Rev area in September 2004 while 42 species were identified in 2003 and 47 species in September 2001. The decline in the number of species occurred both inside the wind farm and reference areas, which indicates that the decline could be a combination of changes in sediment characteristics and natural variation rather than an effect from the establishment of the wind farm. More species were not associated with the hard substrate at the turbine sites in 2004 compared to 2003, while in 2001, more species were associated with fine-grained sand. The median sediment grain size increased from 2001 to 2003 to 2004, which suggests that the velocity of the current increased, but modelling calculations on current speed predicted a 2% reduction in the wind farm area and up to a 15% reduction very close to the scour protection. These results agreed with the grain sizes found at the stations 5, 25 and 100 metres from the scour protection. At most stations, the medium grain size was 5 metres lower from the scour protection compared with the station 100 metres from the scour protection, which indicates that the velocity of the current was lower close to the scour protection. No significant impact on the infauna in the wind farm area was detectable concerning distance-related effects. Though general reductions in the population size of some of the character species in the surveyed areas might be related to changes in the sediment structure, the infauna community at Horns Rev showed no obvious sign of stress response as a consequence of possible impact from construction and operating activities. New species were observed in 2003 and 2004 and some of these might be a result of sediment characteristics, less predation or natural variation. The recording of other species might be a result of the introduction of hard bottom habitants in the wind farm area. The density of the most abundant bivalves and bristle worms was

  3. Horns Rev offshore wind power farm. Environmental impact assessment on water quality

    International Nuclear Information System (INIS)

    Andersen, Per

    2000-05-01

    As part of an overall Environmental Impact Assessment (EIA) undertaken in connection with a planned 150 MW offshore wind farm at Horns Rev, an assessment was made of the effects the wind farm would have on the water quality in the area. This EIA study was drawn up in accordance with the guidelines laid down by the Danish Ministry of Environment and Energy in the publication 'Guidelines for the preparation of EIA studies for offshore wind farms'. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. Only local and minor changes are anticipated in connection with the currents, sediments and wave conditions during the production phase. These will occur in the immediate vicinity of the individual foundations. For these reasons, no changes are expected in the water quality. This also includes also the pelagic primary production and the occurrence of plankton in the area. Increased local copper contamination of phytoplankton and zooplankton may be expected during the production phase, as a result of the total annual discharge of 206 kg copper from the slip-rings in the wind turbines. The contamination will potentially result in a local reduction of the pelagic primary production and changes in the species composition of the plankton. The wind turbines will be sandblasted and painted once during their lifetime, as part of the routine maintenance. The sandblasting and painting will lead to a temporary spill of paint, paint waste and sand. The impacts on water quality and plankton production are unknown. It is recommended that factors such as the toxicity of the paint be investigated, and that spills and the impact of waste be reduced as much as possible. The water quality and the plankton in the wind farm area and along the cable line's passage to shore through the international protected area, will only be affected in a minor way

  4. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2004

    International Nuclear Information System (INIS)

    Bech, M.; Frederiksen, R.; Pedersen, John; Leonhard, S.B.

    2005-04-01

    A total of 40 species were identified from the surveys in the Horns Rev area in September 2004 while 42 species were identified in 2003 and 47 species in September 2001. The decline in the number of species occurred both inside the wind farm and reference areas, which indicates that the decline could be a combination of changes in sediment characteristics and natural variation rather than an effect from the establishment of the wind farm. More species were not associated with the hard substrate at the turbine sites in 2004 compared to 2003, while in 2001, more species were associated with fine-grained sand. The median sediment grain size increased from 2001 to 2003 to 2004, which suggests that the velocity of the current increased, but modelling calculations on current speed predicted a 2% reduction in the wind farm area and up to a 15% reduction very close to the scour protection. These results agreed with the grain sizes found at the stations 5, 25 and 100 metres from the scour protection. At most stations, the medium grain size was 5 metres lower from the scour protection compared with the station 100 metres from the scour protection, which indicates that the velocity of the current was lower close to the scour protection. No significant impact on the infauna in the wind farm area was detectable concerning distance-related effects. Though general reductions in the population size of some of the character species in the surveyed areas might be related to changes in the sediment structure, the infauna community at Horns Rev showed no obvious sign of stress response as a consequence of possible impact from construction and operating activities. New species were observed in 2003 and 2004 and some of these might be a result of sediment characteristics, less predation or natural variation. The recording of other species might be a result of the introduction of hard bottom habitants in the wind farm area. The density of the most abundant bivalves and bristle worms was

  5. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Bech, M.; Leonhars, S.B.; Pedersen, John

    2004-05-15

    ELSAM and ELTRA have established an offshore wind farm with an output of 160 MW in the waters of Horns Rev 1420 km off Blaevands Huk, which is the most westerly point of Denmark. The first phase of construction of the wind farm started in spring 2002. Before the construction activities took place, a baseline description of the benthos was conducted as a part of an environmental monitoring programme for the establishment of the Horns Rev Offshore Wind Farm. The baseline surveys for the present monitoring programme were conducted in the wind farm area on three occasions: spring 1999, spring 2001 and September 2001. In designated reference areas, surveys were conducted in spring 1999 and September 2001. The reference areas in 1999 and September 2001 were placed at two different geographical locations because the survey in September 2001 was planned to be a part of a fish monitoring programme. A comparison between the baseline study in spring 2001 and the baseline study in autumn 2001 clearly revealed that the biomass of most species increased considerably from spring to September. Despite the increase in biomass, the overall distribution of the species and their relative abundance did not change. In order to use the baseline data to investigate a possible impact after the construction of the wind farm, it was essential to arrange the monitoring programme either in spring or in September 2003, because the baseline studies were conducted in these periods. The monitoring programme was conducted in September 2003 after the wind farm had become operational, parallel with the survey on hard bottom substrates. The impacts of the wind farm on the benthic fauna (infauna) in the area were mainly expected to be due to the alteration of the local currents. As the changes in the currents are only minor, impacts on the water chemistry and on the benthic fauna resulting from hydrodynamic causes were expected to be limited or non-existent. The main objective of the present monitoring

  6. A Percepção dos Consumidores Quanto às Características Ecológicas: Análise de Viabilidade Baseada no Modelo Bertolini para Água Mineral

    Directory of Open Access Journals (Sweden)

    Raquel Adriana Gafuri

    2015-12-01

    Full Text Available A conscientização quanto às questões ambientais tem influenciado a decisão de compra e os padrões de consumo que podem indicar a disposição em adquirir um produto com características ecológicas. Este estudo de caso pretende averiguar se investimentos em características ecológicas seriam capazes de trazer retornos financeiros positivos para uma indústria de água mineral de 510 ml. Para tal verificação as análises são feitas com base no modelo proposto por Bertolini (2009, que consistiu em identificar as características ecológicas mais percebidas pelos consumidores, avaliar a disponibilidade em adquirir o produto com tais características, analisar a viabilidade econômica do projeto, além de realizar cruzamentos entre as variáveis. Apurou-se que o fator preço ainda se sobrepõe à conscientização ecológica, e que o consumidor está disposto a pagar o mesmo preço tanto para produto ecológico, quanto para produto convencional. Mesmo diante dessas condições, pode-se dizer que a utilização da ferramenta de análise foi capaz de apontar viabilidade para investimentos em características ecológicas para o produto água mineral de 510 ml.

  7. Une méthodologie d'analyse des effets de la globalisation sur les systèmes régionaux locaux

    Directory of Open Access Journals (Sweden)

    Silvana Lombardo

    1999-06-01

    Full Text Available Ce travail a pour but d'enrichir les études concernant les répercussions du changement de l'économie de l'entreprise au niveau global sur les modèles d'organisation territorial au niveau local les entreprises. La recherche part du constat d'une insuffisance du cadre d'étude et d'un manque d'information systématique généralisé. Dans ce but nous avons essayé d'approfondir certains aspects théoriques relatifs d'une part au modèle de réseau que relie les composantes du système territorial, et d'autre part aux effets de globalisation de l'entreprise.Nous avons abordé l'analyse des systèmes industriels de deux régions de l'Italie - les Abbruzes et le Lazio - très peu étudiées mais qui, dans les années dernières, ont montré de grands changements, notamment en ce qui concerne les PME et la formation de véritables systèmes locaux organisés afin de répondre d'une façon très active aux mutations du système économique global.L'analyse s'appuie sur une enquête directe par questionnaire adressée à un échantillon d'entreprises. La loi sur "la privacy" nous a contraintes à employer les données traditionnelles de l'Institut Central de Statistiques et de l'Union des Chambres de Commerce, à partir desquelles nous avons défini l'univers statistique et construit un échantillon représentatif.Les connaissances produites par l'analyse des données permettent de déterminer les formes des questions et d'identifier les aspects devant être approfondis. Les premières conclusions portent en particulier sur les facteurs principaux des choix de localisation de l'entreprise.

  8. Evaluación de requerimientos ecológicos para el diseño de regímenes ambientales de caudales fluviales

    Directory of Open Access Journals (Sweden)

    Juan Manuel Diez-Hernández

    2008-11-01

    Full Text Available Las sociedades avanzadas medioambientalmente están reclamando progresivamente una gestión fluvial auténticamente integral, que implemente Planes de Manejo de Cuencas Hidrográficas fundamentados en el paradigma del Régimen Ambiental de Caudales (RAC. Este trabajo sugiere una metodología genérica para establecer RAC confiables, que posibiliten el aprovechamiento hídrico a un coste ecológico admisible. Adicionalmente, plantea los criterios y técnicas preferentes para la evaluación de los requerimientos ecosistémicos de caudal, los cuales componen el RAC mediante el Régimen de Caudales Ecológicos (RCE. La adaptación de estos procedimientos para los ríos de Colombia favorecerá la conservación de su valiosa biodiversidad. / The environmentally advanced societies are claiming progressively an authentically integral fluvial management, that implements Watershed Management Programs based on the paradigm of the Environmental Flows Regime (EFR. This work suggests a generic methodology for the reliable EFR setting, that facilitate the water use with an environmental acceptable cost. Additionally, it outlines the approaches and outstanding techniques for the evaluation of instream flow requirements, which constitute the EFR by means of the Instream Flow Regime (IFR. The adaptation of these approaches to the Colombian rivers will contribute to the conservation of their valuable biodiversity.

  9. Ordenamiento ecológico y ordenamiento territorial: retos para la gestión del desarrollo regional sustentable en el siglo XXI

    Directory of Open Access Journals (Sweden)

    Pablo Wong-González

    2010-01-01

    Full Text Available América Latina, se reconoce que a pesar de los avances en la materia, la planificación tradicional en general y los programas de ordenamiento ecológico y territorial en particular, éstos últimos como instrumentos de gestión ambiental directamente ligados al uso del suelo, los esfuerzos han sido preferentemente indicativos y no han estado respaldados políticamente con una aplicación eficaz. El objetivo de este ensayo es llevar a cabo una reflexión analítica de las fuerzas generadoras de cambio y megatendencias que están impactando los procesos de planeación territorial y contribuir a la discusión de alternativas. Para ello se toman como referencia los principales programas de ordenamiento ligados al territorio en México: el Ordenamiento Ecológico y el Ordenamiento Territorial. Se argumenta que por sí mismos ambos ordenamientos, debido a su orientación fundamentalmente sectorial urbana- asentamientos humanos el segundo-, no pueden constituirse en sustitutos de una política comprehensiva de desarrollo regionalterritorial sustentable.

  10. De la comprensión a la aplicación del conocimiento en el diagnóstico ecológico

    Directory of Open Access Journals (Sweden)

    Jaime Matus Parada

    2011-01-01

    Full Text Available Ante la actual crisis socioambiental, los centros de educación superior enfrentan la demanda del conocimiento aplicado en distintos campos. Este texto se refiere al campo de la Biología impartido en la Universidad Autónoma Metropolitana Unidad Xochimilco (uam-x. El artículo explora el grado de relación que los conocimientos conceptuales pueden presentar con la capacidad de aplicación del conocimiento en un dominio cognitivo específico que posee una naturaleza procedimental, el diagnóstico ecológico. Salvo en los casos de los alumnos más aventajados, los resultados sugieren que los esquemas conceptuales que poseen los alumnos no son suficientes para garantizar un desempeño complejo como el que implica el diagnóstico ecológico. Este hallazgo se ve influido por la naturaleza del dominio cognitivo estudiado, caracterizado por una demanda conceptual relativamente moderada, pero también por un desempeño extremadamente amplio y complejo.

  11. El marketing ecológico y su integración en la planificación estratégica

    Directory of Open Access Journals (Sweden)

    Yoleida Hernández

    2012-05-01

    Full Text Available El presente trabajo tuvo como objetivo describir la integración del marketing ecológico en la planificación, con el fin establecer los aspectos que integra dicha tendencia y los beneficios que le aporta a las organizaciones, dentro del contexto ambiental. La investigación es de tipo descriptivo-documental, basada principalmente en los aportes realizados por autores como: Chamorro (2001, David (2003, Kaplan y Norton (2000, López (2007, Lorenzo (2002 y Machín (2003. La revisión realizada permitió concluir, que el marketing ecológico como mecanismo necesario en la planificación estratégica de toda organización, acorde con las exigencias ambientales de los clientes y la sociedad en general, debido a que determina los objetivos ambientales: los elementos presentes en el proceso, su integración con la visión estratégica y las estrategias para alcanzarlos, lo cual le permite a la organización direccionarse hacia una economía verde.

  12. Why the dimension matters in ecological models? ¿Por qué importa la dimensión en modelos ecológicos?

    Directory of Open Access Journals (Sweden)

    Rodrigo Ramos-Jiliberto

    2004-12-01

    Full Text Available In this work we discuss the ecological and mathematical significance of system's dimension in continuous-time population dynamics models. We show how the system's dimension reflects the ecological assumptions and affects both the spectrum of dynamic output and mathematical tractability of the models. We stress that the model dimension is not always the same as the number of state-variables, and we also present conditions under which the system's dimension is alteredEn este trabajo discutimos la significación ecológica y matemática de la dimensión del sistema en modelos de dinámica poblacional en tiempo continuo. Mostramos cómo la dimensión del sistema refleja los supuestos ecológicos y afecta el espectro de resultados dinámicos así como la tratabilidad matemática de los modelos. Acentuamos que la dimensión de un modelo no es siempre equivalente al número de variables de estado, y presentamos condiciones bajo las cuales la dimensión del sistema es alterada.

  13. Balance sheet method assessment for nitrogen fertilization in winter wheat: II. alternative strategies using the CropSyst simulation model

    Directory of Open Access Journals (Sweden)

    Maria Corbellini

    2006-09-01

    Full Text Available It is important, both for farmer profit and for the environment, to correctly dose fertilizer nitrogen (N for winter wheat growth. Balance-sheet methods are often used to calculate the recommended dose of N fertilizer. Other methods are based on the dynamic simulation of cropping systems. Aim of the work was to evaluate the balance-sheet method set up by the Region Emilia-Romagna (DPI, by comparing it with the cropping systems simulation model CropSyst (CS, and with an approach based on fixed supplies of N (T. A 3-year trial was structured as a series of N fertility regimes at 3 sites (Papiano di Marsciano, Ravenna, San Pancrazio. The N-regimes were generated at each site-year as separate trials in which 3 N rates were applied: N1 (DPI, N2 (DPI+50 kg ha-1 N at spike initiation, N3 (DPI + 50 kg ha-1 N at early booting. Above ground biomass and soil data (NO3-N and water were sampled and used to calibrate CS. Doses of fertilizer N were calculated by both DPI and CS for winter wheat included in three typical rotations for Central and Northern Italy. Both these methods and method T were simulated at each site over 50 years, by using daily generated weather data. The long-term simulation allowed evaluating such alternative fertilization strategies. DPI and CS estimated comparable crop yields and N leached amounts, and both resulted better than T. Minor risk of leaching emerged for all N doses. The N2 and N3 rates allowed slightly higher crop yields than N1.

  14. Bird numbers and distribution in the Horns Rev offshore wind farm area. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This report presents data from six aerial surveys of birds in the Horns Rev wind farm area in 2003. Including 16 surveys conducted before construction of the wind farm started and three during the construction phase, a total of 25 surveys have been performed in the area since August 1999. Up until August 2002 the study area was surveyed from 26 north-south oriented, parallel transect lines. After that time four short transects were added eastwards from the previously easternmost transect. From August 2002 slight adjustments to the transect lines in the wind farm area had to be made in order to avoid collision, as survey altitude was 76 m and wind turbines are 110 m to highest wing tip. The six surveys in 2003 were performed on 13 February, 16 March, 23 April, 5 September, 4 and 30 December. The operational phase of the wind farm commenced in 2002. Hence the six surveys from 2003 are all considered post-construction data sets. A preliminary evaluation of the potential impact of the wind turbines on bird distributions has been carried out by comparison of these data to those from the 16 pre-construction surveys. (au)

  15. Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production

    Science.gov (United States)

    Na, Hong; Huisman, Willem; Ellestad, Kristofor K.; Phillips, Tom R.; Power, Christopher

    2010-01-01

    Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analyses were performed in both an infectious FIV molecular clone and a FIV CAT-RRE reporter system. These studies disclosed that the stems within SLA (SA1, 2, 3, 4, and 5) of the RRE were critical but SA6 was not essential for FIV replication and CAT expression. These studies also revealed that the secondary structure rather than an antisense protein (ASP) mediates virus expression and replication in vitro. In addition, a single synonymous mutation within the FIV-RRE, SA3/45, reduced viral reverse transcriptase activity and p24 expression after transfection but in addition also showed a marked reduction in viral expression and production following infection. PMID:20570310

  16. Sondeo ecológico rápido de las comunidades de peces tropicales en un área de explotación minera en Costa Rica

    Directory of Open Access Journals (Sweden)

    Mario Espinoza Mendiola

    2008-12-01

    Full Text Available El impacto de las minerías de oro ha generado una gran preocupación por el deterioro de los hábitats acuáticos y la fragmentación de los sistemas naturales. Las perturbaciones antropogénicas sobre la estructura y heterogeneidad del sistema pueden influir en la estabilidad de las comunidades acuáticas. Sondeos ecológicos rápidos (1996, 2002, 2007 fueron empleados para determinar la estructura, composición y distribución de las comunidades de peces tropicales en varios ríos y quebradas del área de una minería de oro en el Cerro Crucitas, Costa Rica. Además, la composición de especies y abundancia relativa se relacionó con la estructura del hábitat. Se registró un total de 35 especies, de las cuales la sardina Astyanax aeneus (Characidae y la olomina Alfaro cultratus (Poeciliidae fueron las especies más abundantes (71%. La mayor riqueza de especies se observó en el Caño Crucitas (s = 19 y la quebrada Minas (s = 18. Se encontró una gran variación en la estructura y composición de las comunidades de peces, principalmente, en el río Infiernillo y Minas (λ = 0.0, F132, 66 = 2.24, p Rapid ecological assessment of tropical fish communities in a gold mine area of Costa Rica. Gold mining impacts have generated a great concern regarding aquatic systems and habitat fragmentation. Anthropogenic disturbances on the structure and heterogeneity of a system can have an important effect on aquatic community stability. Ecological rapid assessments (1996, 2002, and 2007 were employed to determine the structure, composition and distribution of tropical fish communities in several rivers and smaller creeks from a gold mining area in Cerro Crucitas, Costa Rica. In addition, species composition and relative abundance were related with habitat structure. A total of 35 species were registered, among which sardine Astyanax aeneus (Characidae and livebearer Alfaro cultratus (Poeciliidae were the most abundant fish (71%. The highest species

  17. Resposta imunitária à vacinação conjuntival com a estirpe Rev.1 de Brucella melitensis em ovinos e caprinos Serological response of sheep and goats to conjunctival Brucella melitensis Rev.1 vaccine

    Directory of Open Access Journals (Sweden)

    P. Poeta

    2003-04-01

    Full Text Available The live B. melitensis Rev.1 strain is considered the best vaccine available for the prophylaxis of brucellosis in small ruminants, especially when used at the standard dose by the conjunctival route. In the present study a 1´ 10(9 CFU dose for both sheep and goats conjunctivally vaccinated was tested to evaluate the duration of serological responses. Conjunctival vaccination with Rev. 1 performed in adult animals induced a rapid rise in serological titres as measured by Rose Bengal Plate Test (RBPT, Complement Fixation Test (CF and Modified Rose Bengal Plate Test (MRBPT. Titres then decreased and became negative in most animals by four months after vaccination (except MRBPT. The goats responded better to the vaccination than the sheep as one month after vaccination 100% of the goats revealed positive results to RB and RBM and 93.4% to FC test. The RBM was the one that detected more positive animals along the study.

  18. Administrative circulars No. 22A (rev. 1) – Award of additional periods of membership in the Pensions Fund for long-term shift work and No. 22B (rev. 1) – Compensation for long-term shift work hours

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circulars No. 22A (Rev. 1) entitled "Award of additional periods of membership in the Pension Fund for long-term shift work" and No. 22B (Rev.1) entitled “Compensation for long-term shift work hours”, adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 March 2011, are available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp They cancel and replace Administrative Circulars No. 22A and 22B entitled "Award of additional periods of membership in the Pension Fund to shift workers (Early Departure)” and “Duration and special compensation for shift work” of January 2000. This new version clarifies, in particular, the compensation of effective long-term shift work hours. Department Head Office  

  19. Afinidad ecológica y distribución actual de Primates (Cebidae en Campeche, México

    Directory of Open Access Journals (Sweden)

    Eloísa Navarro Fernández

    2003-06-01

    Full Text Available Realizamos recorridos de campo durante la temporada de marzo a septiembre del 2000 para obtener la distribución actual de cébidos presentes en el estado de Campeche, México. Por medio de encuestas y observaciones directas, se determinó la distribución de Ateles geoffroyi yucatanensis, Alouatta pigra y se documentó por primera vez localidades en Campeche donde se encuentra Alouatta palliata mexicana. Se elaboraron mapas de distribución de las especies con la ayuda de los paquetes ArcInfo y ArcView por medio de la sobreposición de coberturas de vegetación, obtenidas en el Inventario Nacional Forestal (1995 y los puntos de registro obtenidos durante el trabajo de campo. En los mapas se presenta la distribución verificada y probable de cada especie. Con la ayuda de los atributos de dicho inventario se calcularon las áreas de distribución confiable resultando 22 736 km 2 para Alouatta sp. y 18 501 km 2 para A. g. yucatanensis. Se presenta la superficie ocupada por cada especie en los diferentes tipos de vegetación y el porcentaje respectivo, así como el porcentaje de ocupación de las especies en el territorio del Estado, para la discusión de las afinidades ecológicas. Para Alouatta, se corroboró su capacidad para soportar la presión de encontrase en ambientes perturbados ocasionados por la fragmentación del hábitat, al ser este ambiente el ocupado con mayor proporción por este género. En el caso de A. g. yucatanensis encontramos que presenta una mayor afinidad a los ambientes no perturbados.We carried out surveys realized field work from March to September 2000 to get the current distribution of Cebids in the state of Campeche, Mexico. Based on interviews and direct observations. We defined the distribution of Ateles geoffroyi yucatanensis and Alouatta pigra and we documented the first time localities where Allouata palliata is found in the state. We made distributional maps of each species using vegetation overlays from

  20. HRensembleHR. High resolution ensemble for Horns Rev. Final project report; Offshore wind power

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The wind farm output of an offshore-farm such as Horns Rev changes between nearly constant output to highly variable power output. A balance responsible will therefore benefit from knowing the variability of a wind farm in advance. Some understanding of the observed variability and the corresponding forecast error on offshore wind farms had been gathered in the past few years, while a large fraction (about 60%) of the error still lacked understanding and required further intense research. This was the outset at the beginning of the HREnsemble project. Results from the wave study, variability study, ocean coupling, findings from the sensitivity experiments, the iEnKF short-term forecast and finally the demonstration phase have given significant synergy. The most basic research result in the project is that the two empirical mode decomposition approaches, Hilbert-Huang and later the Ensemble Empirical Mode Decomposition (EEMD). Both approaches confirmed that significant variability exists in offshore conditions. It was found that the variability of the short time-scales (24 minutes) are either not explicitly visible in the grid-scale of the NWP models or in the best case significantly smoothed out in all of the tested model configurations. If we interpret 2/3 of the variability due to vertical waves not present in the mean flow and 1/3 of the variability due to meso-scale weather, then the model results and EEMD are consistent. We can however not verify this theory. At present we do not know if EEMD counts neither the events correct nor whether the ensemble forecast suppresses variability. The existence of variability above the time-scale related to friction between ocean waves and air can in fact explain some of the inconsistent results published in the literature and set a question mark behind the correctness of the calculation of friction in wave, ocean and weather modelling. (LN)

  1. NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

    Science.gov (United States)

    Güttler, Thomas; Madl, Tobias; Neumann, Piotr; Deichsel, Danilo; Corsini, Lorenzo; Monecke, Thomas; Ficner, Ralf; Sattler, Michael; Görlich, Dirk

    2010-11-01

    Classic nuclear export signals (NESs) confer CRM1-dependent nuclear export. Here we present crystal structures of the RanGTP-CRM1 complex alone and bound to the prototypic PKI or HIV-1 Rev NESs. These NESs differ markedly in the spacing of their key hydrophobic (Φ) residues, yet CRM1 recognizes them with the same rigid set of five Φ pockets. The different Φ spacings are compensated for by different conformations of the bound NESs: in the case of PKI, an α-helical conformation, and in the case of Rev, an extended conformation with a critical proline docking into a Φ pocket. NMR analyses of CRM1-bound and CRM1-free PKI NES suggest that CRM1 selects NES conformers that pre-exist in solution. Our data lead to a new structure-based NES consensus, and explain why NESs differ in their affinities for CRM1 and why supraphysiological NESs bind the exportin so tightly.

  2. ADMINISTRATIVE CIRCULAR No. 25 (REV. 3) - Special provisions for the fire and rescue service governing working and rest time

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 25 (Rev. 3) entitled “Special provisions for the Fire and Rescue Service governing working and rest time”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 28 September 2012 and entering into force in October 2012, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp This Circular is applicable to staff members of the Fire and Rescue Service It cancels and replaces Administrative Circular No. 25 (Rev. 2) entitled “Shift work – Special provisions for the Fire and Rescue Service” of April 2003. This new version takes into account the new organisation of the Fire and Rescue Service, members of which will henceforth not exclusively perform their functions in the context of shift work, but also during reference working hours and during stand-by duty. Additionally, applicable limits regarding working and rest times an...

  3. Operational Circular No.2 (Rev. 2) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    2014-01-01

    Operational Circular No. 2 (Rev. 2) entitled “Conditions of access to the fenced parts of the CERN site” and its “implementation measures”, approved by the Director-General following discussion at the Standing Concertation Committee meeting on 20 May 2014 and entering into force on 1 September 2014, are available on the intranet site of the Human Resources Department (see here).   This circular is applicable to members of the personnel and other persons concerned. It cancels and replaces Operational Circular No. 2 (Rev. 1) entitled “Conditions of access to the fenced parts of the CERN site”, of April 1998. In particular, the revised circular provides for the possibility of mandating a person responsible for the proper implementation of the circular, specifies the rules relating to vehicles allowed on the site and the respective responsibilities of their owners, and relaxes certain administrative formalities in case of loss, theft or di...

  4. Operational Circular No. 2 (Rev. 3) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    HR Department

    2015-01-01

    Operational Circular No. 2 (Rev. 3) entitled "Conditions of access to the fenced parts of the CERN site", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 24 September 2015, is now available via this link.   This revised circular cancels and replaces Operational Circular No. 2 (Rev. 2) also entitled "Conditions of access to the fenced parts of the CERN site", of September 2014. The circular was revised predominantly in order to specify that access to the CERN site is granted to CERN Pension Fund beneficiaries only provided that they are actually in receipt of payments from the Fund; and to allow the Director-General to permit special types of vehicles on site, such as trailers. It also includes a certain number of text improvements and an updated version of the implementation measures, in particular with regard to vehicle identification, road traffic and parking.  

  5. Administrative circular n°3 (Rev. 2) – Home leave, travel to home station and assimilated leave and travel

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 3 (Rev. 2) entitled “Home leave, travel to the home station and assimilated leave and travel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to employed members of the personnel. It cancels and replaces Administrative Circular No. 3 (Rev. 1) entitled “Travel to the home station and home leave” of June 2002. The circular was revised in order to take into account the new status of Associate Member State and the fact that henceforth, home stations may be situated on territory outside of Europe. It is proposed to introduce a new system of determination of the benefits (Travel expenses, travel time and distance indemnity) granted in the context of home leave and supplementary journeys to the home station.  For t...

  6. Changements climatiques au Maroc: quels systèmes de culture et quelles biotechnologies pour s’y adapter ?

    Directory of Open Access Journals (Sweden)

    Abdelhadi AIT HOUSSA

    2017-09-01

    scale use of seawater in agriculture or finding new salinity tolerant cultivars. In Morocco, we should think of desalinization with renewable energies (solar, wind and the use of this water mainly in coastal areas where climate, land quality, sun and wind are adequate to these projects. To anticipate the future of food security of the country, attention should be given to the use of readily available resources to overcome the structural deficit in wheat starch and animal protein. The study suggests the use of other starch sources that Morocco can produce easily such as potato. For animal protein, we suggest fisheries resources which are still underused by the population. Résumé On présente une étude prospective concernant l’impact probable des changements climatiques sur les systèmes de culture et d’élevage au Maroc. D’après le constat de terrain et dans les limites de ce que signifie ce genre d’étude, l’effet direct du réchauffement climatique peut conduire à terme (et c’est déjà le cas dans certaines contrées à la nécessité d’une redistribution variétale pour des espèces exigeantes en froid comme les rosacées. Des variétés de pomme, telle que le groupe des Golden, risquent de disparaître des montagnes pour laisser la place à d’autres moins exigeantes comme le groupe des Gala. Le bananier et l’avocatier risquent de migrer vers les régions un peu plus continentales, l’olivier et les agrumes un peu plus vers le pied de la montagne. Le réchauffement climatique peut aussi obliger à faire évoluer les systèmes d’élevage et de culture en faisant déplacer la frontière de la sécheresse un peu plus vers le centre et le nord du pays; l’aride serait peut-être envahi par la désertification, le semi-aride passerait en partie à l’étage aride et le Bour dit favorable en partie dans le semi-aride. Comme corollaire à ce changement, il faudrait s’attendre à une perte de potentiel de ressources en eau qui obligerait

  7. HRensembleHR. High resolution ensemble for Horns Rev. Final project report. Executive summary; Offshore wind power

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The development of offshore wind power results in more energy production per area unit and new requirements to the generation forecasts. Measurements from Horns Rev and ensemble forecasts were used to upgrade forecasting tools for the relevant periods and time scales. The most significant development is a new algorithm for short-term forecasts that combines any relevant online measurements by means of ensemble forecasts. (ln)

  8. Comment on "Total Negative Refraction in Real Crystals for Ballistic Electrons and Light" (Phys. Rev. Lett. 91, 157404 (2003))

    OpenAIRE

    Yau, H. -F.; Liu, J. -P.; Ke, B.; Kuo, C. -H.; Ye, Z.

    2003-01-01

    Recently, Zhang et al. (Phys. Rev. Lett. 91, 157404 (2003)) have demonstrated that an amphoteric refraction, i. e. both positive and negative refraction, may prevail at the interface of two uniaxial anisotropic crystals when their optical axes are in different directions. The authors subsequently made a correspondence between such a refraction with the negative refraction expected for Left Handed Materials (LHMs). Here we comment that the amphoteric refraction can be observed even with one un...

  9. Índice de estado limnológico (IEL para evaluar las condiciones ecológicas de las ciénagas del Canal del Dique

    Directory of Open Access Journals (Sweden)

    Gabriel Antonio Pinilla Agudelo

    2010-05-01

    Full Text Available Determinar el estado o salud ecológica de un ecosistema brinda herramientas útiles para su gestión y conservación. En Colombia no se han desarrollado índices que combinen en un solo parámetro las variables físicas, químicas y biológicas de los sistemas acuáticos, de manera que la evaluación de su estado ecológico ha sido fragmentaria o incompleta. En este trabajo se presenta el desarrollo de un Índice de Estado Limnológico (IEL para las ciénagas del Canal del Dique, ecosistemas sometidos a constante presión por parte de las comunidades humanas. Para la construcción de este índice multimétrico se realizó un análisis de componentes principales, se construyeron gráficas de calidad de las variables seleccionadas y se les asignaron valores de importancia. Se empleó la teoría de los multiatributos para construir el IEL, el cual considera 12 variables. Se diseñó una versión simplificada (IEL parcial - IELP en la que se excluyeron 4 de las variables biológicas. Finalmente, se construyó una escala de interpretación de los valores obtenidos con estos índices. El IEL y el IELP se aplicaron a las ciénagas del Canal del Dique para establecer su condición ecológica actual. Los datos muestran que el estado limnológico de la mayoría de ciénagas de esta región es aceptable, lo que sugiere que estos ecosistemas lénticos se encuentran dentro de los límites admisibles de funcionamiento, aunque no están excentos de procesos de deterioro.

  10. Reciclo-óleo: do óleo de cozinha ao sabão ecológico, um projeto de educação ambiental

    Directory of Open Access Journals (Sweden)

    Maria Isabel Morgan Martins

    2016-10-01

    Full Text Available O consumo de óleo faz parte do dia-a-dia das famílias, restaurantes, indústrias e com ele o descarte incorreto do óleo de cozinha usado (OCU se torna um grave problema ambiental. Quando despejado no lixo comum impermeabiliza e contamina o solo, porque a decomposição aumenta o efeito estufa, na rede de esgoto compromete as tubulações das residências e das cidades e ao atingir os rios forma uma película na água que impede a passagem de luz e oxigênio a flora e a fauna aquática. Objetivo: é promover a educação ambiental para o descarte correto e a reciclagem do óleo de cozinha usado, transformando-o em sabão em barra ecológico, gerando renda e sustentabilidade. Método/ atividades de extensão: o projeto apresenta duas linhas bem definidas à educação ambiental e o desenvolvimento de receitas que transformam do OCU em sabão em barra ecológico. O projeto educa para a consciência e responsabilidade ambiental a diferentes grupos da comunidade, ensina e orienta a importância de dar o destino correto ao OCU, bem como, a reciclagem com sustentabilidade, criando alternativa de geração de renda. Desde 2010, as oficinas foram realizadas em diferentes bairros, escolas e empresas dos municípios da grande Porto Alegre, RS. As receitas foram desenvolvidas no laboratório do campus da ULBRA Gravataí, e apresentam baixo custo, para a fabricação “caseira” do sabão ecológico. O primeiro processo é educar com consciência ambiental. Considerações finais: o reciclo-óleo contribui para o combate à poluição e manutenção dos recursos naturais. Portanto, com ações de educação em saúde é possível refletir positivamente na preservação do meio ambiente, contribuindo, dessa forma, para o desenvolvimento sustentável e para a promoção da saúde das cidades.

  11. Evaluación externa en la LOMCE. Reválidas, exclusión y competitividad

    Directory of Open Access Journals (Sweden)

    Ángel I. Pérez Gómez

    2014-01-01

    Full Text Available La evaluación de las competencias o cualidades humanas que cada aprendiz ha de desarrollar de manera singular para afrontar la complejidad de la era digital contemporánea es incompatible con las reválidas, test y pruebas externas estandarizadas, iguales para todos. Las cualidades más importantes del aprendizaje en la era digital —autodirección, iniciativa, creatividad, pensamiento crítico, solución de problemas y autoevaluación— son difícilmente evaluables mediante instrumentos baratos y masivos «de papel y lápiz», como los test estandarizados o las reválidas externas; requieren, por el contrario, herramientas y procesos más complejos, plurales y flexibles como la observación continua de los equipos docentes sobre el quehacer y los procesos y productos de los aprendices (Soto Gómez, 2014. La LOMCE,1 fiel exponente de la pedagogía conservadora del movimiento GERM,2 recupera las reválidas, pues apuesta por la estandarización de aprendizajes superficiales en lugar de potenciar el desarrollo singular de cada aprendiz hasta el máximo de sus posibilidades.

  12. An analysis of international situation concerning nuclear security. Focused on the revision to INFCIRC/225/Rev.5

    International Nuclear Information System (INIS)

    Inamura, Tomoaki; Tanabe, Tomoyuki

    2011-01-01

    Since the September 11 attacks in 2001, counterterrorism measures have become not just domestic issues but critical issues that need international cooperation. Various nuclear security measures are in place as part of international counterterrorism measures. This report looks at the trend of international nuclear security measures to get implications for Japan, focusing on INFCIRC/225/Rev.5, an international guideline for physical protection of nuclear materials and nuclear facilities drawn up by IAEA. The observations of this report are as follows: 1) While legally binding nuclear security measures such as multilateral treaties and United Nations Security Council Resolutions impose minimum requirements on individual countries, the approaches led by IAEA or individual countries or private associations aim at more detailed consideration or information sharing to further improve nuclear security. 2) INFCIRC/225/Rev.5 comprises new concepts such as risk-based physical protection and nuclear security culture, as well as extended range of threats such as insiders or stand-off attacks and broader scope of measures to response. Japan should consider incorporation of INFCIRC/225/Rev.5 to its national laws and regulations putting in mind that it may have heavy influence and that Japan pledged to role leadership about nuclear security to international society. (author)

  13. Safety and efficacy of reduced doses of Brucella melitensis strain Rev. 1 vaccine in pregnant Iranian fat-tailed ewes

    Directory of Open Access Journals (Sweden)

    Mohammad Ebrahimi

    2012-12-01

    Full Text Available Brucellosis is one of the most important zoonotic diseases and is a significant cause of abortion in animals. Brucella melitensis strain Rev. 1 is recommended as the most effective vaccine for small ruminants but the application of full doses in adult animals is restricted. This study was conducted to determine a proper reduced dose of vaccine which confers protection but which is not abortifacient in Iranian fat-tailed sheep. A total of 51 non-vaccinated pregnant ewes were divided into three main groups and several subgroups. Ewes in different groups were vaccinated at different stages of pregnancy and various subgroups were subcutaneously immunised with different quantities of the micro-organism (7.5 × 106, 106, 5 × 105. Ewes again became pregnant a year later and were challenged with the wild-type strain to evaluate the protection conferred. Results revealed that the proportion of vaccination-induced abortions was significantly higher in ewes immunised with 7.5 × 106 Rev. 1 organisms than in those which received 106 or 5 × 105 bacteria. While 80% of non-vaccinated ewes aborted after challenge, none of the vaccinated ewes aborted post-challenge. This study indicated that a reduced dose of Rev. 1 vaccine containing 106 or 5 × 105 live cells could be safely used to induce protection in Iranian fat-tailed sheep at various stages of pregnancy.

  14. Pour mesurer le débit de l'Indus : un nouveau système de prévision ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 juil. 2011 ... Un partenariat de recherche entre le Pakistan et le Canada a mené au lancement d'un système de prévision très perfectionné qui promet d'aider les autorités pakistanaises à mesurer avec précision le débit de l'Indus, principale artère d'un des plus grands réseaux d'irrigation du monde.

  15. The Odda System: Integration of Conventional Programming and Artificial Intelligence Le système ODDA : intégration de programmation classique et d'intelligence artificielle

    Directory of Open Access Journals (Sweden)

    Cayeux E.

    2006-11-01

    Full Text Available The ODDA system (Offshore Directional Drilling Advisor is an example of how numerical packages, a relational database, graphical interfaces and knowledge bases can be integrated into an industrial application. Le système ODDA (Offshore Directional Drilling Advisor est un exemple illustrant la façon dont des progiciels numériques, une base de données relationnelle, des interfaces graphiques et des bases de connaissances peuvent être intégrés dans une application industrielle.

  16. Politiques et dynamique des systèmes de production: comment concilier défi alimentaire, compétitivité et environnement ?

    OpenAIRE

    Chatellier, Vincent; Dupraz, Pierre

    2011-01-01

    Cette communication propose une réflexion portant sur l’influence des politiques publiques (commerciale, agricole et environnementale) sur la dynamique des systèmes de production en agriculture. Elle rappelle, dans un premier temps, que les politiques commerciales définies dans le cadre des accords de l’OMC contribuent à une libéralisation accentuée des marchés agricoles internationaux. En se focalisant sur les principales productions agricoles développées dans l’Union européenne (céréales, l...

  17. L'intégration des TIC dans un environnement éducatif conditionné par le système du 'spoon-feeding.'

    OpenAIRE

    Saurty , Krishnah Moortee

    2013-01-01

    Cet article prend son essence dans un projet pédagogique dont la préoccupation est de renforcer les savoirs notamment à travers le concept d'apprentissage intégrant les Technologies de l'Information et de la Communication (Tic) afin de développer des actions éducatives pouvant apporter des réponses réelles aux principes du 'spoon-feeding', véritable pilier du système éducatif mauricien s'appuyant sur le contenu du savoir disciplinaire et conditionnant l'apprenant dans sa capacité à développer...

  18. Analýza systému franchisingu McDonald´s v podmínkách EU

    OpenAIRE

    Nováková, Monika

    2007-01-01

    Tato práce hodnotí systém franchisingu - v teoretické části obecně, dále v ČR i v zahraničí. V aplikaci pak na firmě McDonald´s. V práci je obsažen i aspekt ekologie, médií a globální pohled. Také vedlejší činnosti McDonald´s, McDonald´s Cup a charita.

  19. Mamíferos silvestres de la Reserva Ecológica del Pedregal de San Ángel en Ciudad Universitaria, Universidad Nacional Autónoma de México, México, D. F. Wild mammals of Reserva Ecológica del Pedregal de San Ángel, Ciudad Universitaria, UNAM, Mexico, D.F.

    OpenAIRE

    Yolanda Hortelano-Moncada; Fernando A. Cervantes; Aída Trejo-Ortiz

    2009-01-01

    Se realizó un inventario de las especies de mamíferos que habitan en la Reserva Ecológica del Pedregal de San Ángel (REPSA). Los datos se obtuvieron a partir de registros de colecciones científicas, de recolectas recientes en el área y de consultas en literatura especializada. Los resultados comprenden 628 registros acumulados desde 1943 y corresponden a 33 especies, agrupadas en 28 géneros, 15 familias y 6 órdenes de mamíferos. La ardilla gris (Sciurus aureogaster nigrescens) y el ratón del ...

  20. Correlación ecológica entre consumo de bebidas alcohólicas y mortalidad por cirrosis hepática en México

    OpenAIRE

    NARRO-ROBLES JOSÉ; GUTIÉRREZ-AVILA JESÚS HECTOR

    1997-01-01

    Objetivo. Determinar la correlación entre consumo de bebidas alcohólicas y mortalidad por cirrosis hepática. Material y métodos. Se efectuó un análisis de correlación ecológica entre el conjunto de variables que integran el patrón de consumo de bebidas alcohólicas investigadas en la Encuesta Nacional de Adicciones en 1993 y la mortalidad por cirrosis hepática, en el periodo 1971-1993 en las ocho regiones en que fue dividido el país. Para determinar el nivel de correlación se utilizaron los co...

  1. Nucleation in tropical ecological restoration A nucleação na restauração ecológica de ecossistemas tropicais

    Directory of Open Access Journals (Sweden)

    Ademir Reis

    2010-04-01

    Full Text Available Ecological theories of facilitation and nucleation are proposed as a basis for environmental restoration in tropical ecosystems. The main goal of this paper is to present restoration techniques based on the concept of nucleation, in which small nuclei of vegetation are established within a degraded land. The nucleation techniques (artificial shelters for animals, planting of herbaceous shrub life forms, soil and seed bank translocation, seed rain translocation, soil and seed rain translocation's seedling set, artificial perches, planting of native trees in groups, and ecological stepping-stones with functional groups promote the landscape connectivity on two flows: inward: receiver connectivity and outward: donor connectivity. The nuclei development represents an alternative for restoration by prioritizing the natural processes of succession. This methodology appears to take long to generate vegetation corresponding to tropical climates, but is fundamental in the formation of communities capable of acting, in the future, as a new functional nuclei within the current fragmented landscape. This strategy also encourages greater integration between the theories and projects of ecological restoration for the development of human resources and to benefit the restoration practitioner.As teorias ecológicas da facilitação e nucleação são propostas como base para a restauração ambiental de ecossistemas tropicais. Nesse "Ponto de Vista" apresentam-se técnicas de restauração fundamentadas no conceito de nucleação, onde pequenos núcleos de vegetação são implantados em uma área degradada. As técnicas de nucleação (abrigos artificiais para animais, plantio de espécies herbáceo-arbustivas, transposição de solo e banco de sementes, transposição de chuva de sementes, blocos de mudas procedentes de transposição de solo e chuva de sementes, poleiros artificiais, plantio de árvores nativas em grupos de Anderson, e trampolins ecol

  2. Fatores ecológicos associados à colonização e ao desenvolvimento de macrófitas aquáticas e desafios de manejo

    OpenAIRE

    Thomaz,S.M.

    2002-01-01

    As macrófitas constituem-se em uma importante assembléia de ecossistemas aquáticos continentais, mas seu crescimento excessivo pode provocar danos aos usos múltiplos de alguns ambientes. Durante o processo de sucessão ecológica, a maioria dos ecossistemas aquáticos é colonizada, em diferentes graus, pela vegetação aquática. No entanto, explosões populacionais são usualmente decorrentes de ações antrópicas, como introduções de espécies exóticas e alterações de habitats. O conhecimento da ecolo...

  3. Impacto turístico, cultural e histórico del circuito turístico ecológico bolivariano Colombia-Venezuela

    OpenAIRE

    Sánchez Segrera, José Rafael

    2015-01-01

    El desarrollo de la presente propuesta ha permitido identificar la necesidad que se tiene de dar inicio a la promoción del turismo histórico, a través del Circuito Turístico Bolivariano en los Distritos Turístico, Cultural e Histórico de Santa Marta y Federal de Caracas, a los que une la historia por ser las ciudades en las que nació el 24 de julio de 1783 y falleció el 17 de diciembre de 1830, el Libertador Simón Bolívar. El Circuito Turístico Ecológico Bolivariano Local dentro del Distri...

  4. El Plan Director de La Vega Baja de Toledo, España: Paisaje patrimonial, ecológico y urbano

    Directory of Open Access Journals (Sweden)

    Agustín Hernández Aja

    2014-11-01

    El planteamiento general del PDVB ha sido tratar el espacio como un continuo abierto, una sucesión de paisajes con su propio carácter, que alberguen distintos usos y funciones: Desde el jardín clásico que rodearía al circo romano, llegando hasta el río, con una vegetación, mobiliario y recorridos acordes con las ruinas existentes; pasando por el jardín patrimonial del yacimiento, para el que se proponen plantaciones e itinerarios efímeros que cambien a la par que avanzan las excavaciones; hasta el paisaje más puramente agrícola del vivero o paisaje de ribera, de gran valor ecológico en relación con la fauna aviar.

  5. Estudos ecológicos preliminares e caracterização química dos Cnidaria da costa noroeste portuguesa

    OpenAIRE

    Gadelha, Juliana Rodrigues

    2007-01-01

    O levantamento de recursos em espécies marinhas em Portugal ainda é incipiente, considerando que este domínio de investigação tem sido amplamente desenvolvido noutros pontos do globo, pescas, química, bioquímica e farmacologia de organismos marinhos, de modo a obter informações sobre a química de produtos naturais e ecologia química de organismos marinhos derivadas destes organismos. São de realçar a importância das defesas químicas para as relações ecológicas de predação, comp...

  6. Sucessão ecológica, entropia e o Modelo Autonomia-Heteronomia para análise dos sistemas agrícolas

    Directory of Open Access Journals (Sweden)

    Rodrigo Aleixo Brito de Azevedo

    2017-04-01

    Full Text Available É proposto o modelo analítico Autonomia-Heteronomia, de caráter agronômico, para descrição e análise dos sistemas agrícolas. Os sistemas autônomos caracterizam-se por utilização preferencial dos recursos locais e estratégias orientadas ao atendimento das necessidades locais ou regionais. São sistemas de baixa entropia e localizados nos estágios mais avançados da sucessão ecológica. Os sistemas heterônomos caracterizam-se por utilização preferencial dos recursos globais e orientação preferencialmente para a mercantilização. São sistemas de alta entropia e localizados nos estágios mais iniciais da sucessão.

  7. Compartimentação geoambiental no complexo de campo maior, PI: uma área de tensão ecológica

    OpenAIRE

    Barros,José Sidiney; Castro,Antônio Alberto Jorge Farias

    2006-01-01

    A região pesquisada, localizada numa área de tensão ecológica, foi submetida a estudos de compartimentação geoambiental de suas unidades, segundo pressupostos da teoria geossistêmica. A vegetação, em manchas ou capões, configura tipos fisionômicos com contatos abruptos ou gradacionais, instalados em solos submetidos a processos de lateritização e ferralitização. Foram analisadas relações entre solo, vegetação, estrutura, florística e diversidade em oito parcelas de 20m x 50m, registrando-se 4...

  8. Consumo de combustíveis no Brasil e Mato Grosso: estimativa do custo ecológico da emissão de gases de efeito estufa

    Directory of Open Access Journals (Sweden)

    Vallência Maíra Gomes

    2012-01-01

    Full Text Available O principal objetivo deste trabalho foi estimar o nível da emissão de gases deefeito estufa (GEE a partir do consumo de combustíveis fósseis e renováveis noBrasil e no estado de Mato Grosso entre os anos de 2003 e 2010. Uma vezreconhecido o quantum de emissão de GEE, calculou-se o custo ecológico destaemissão a partir dos preços da tonelada de carbono comercializada na BolsaEuropeia do Clima e na Bolsa do Clima de Chicago. A partir deste exercício,estimou-se o peso deste custo ecológico sobre o Produto Interno Bruto do Brasil ede Mato Grosso no período analisado, considerando hipoteticamente a incorporaçãodestes custos externos na matriz produtiva de ambas as referências espaciais.Utilizando a base de dados de consumo de combustíveis do Brasil e de Mato Grossoda Agência Nacional de Petróleo, Gás Natural e Biocombustíveis, foi empregado oMétodo “Top-Down” ou método de referência do IPCC para estimar as emissões dedióxido de carbono. Atrelou-se o preço do carbono nas Bolsas da Europa e dosEstados Unidos à emissão de gases do efeito estufa, para se estimar os custosexternos, chamados aqui também de custos ecológicos. Os resultados mostram queos custos ecológicos estão tendendo a redução neste período, tanto pela contençãoda emissão de GEE frente ao PIB quanto pela tendência negativa dos preços docarbono nas bolsas internacionais.Abstract The main objective of this study was to estimate the level of greenhouse gasesemission (GHG from the consumption of fossil and renewable fuels in Brazil and inthe state of Mato Grosso between the years 2003 and 2010. Once recognized thequantum of GHG emission, was calculated the ecological cost of this emission asfrom the prices of the ton of carbon traded on the European Climate Exchange andon the Chicago Climate Exchange. From this exercise, was estimated the weight ofthis ecological cost on Gross Domestic Product (GDP of the Brazil and of MatoGrosso in the period

  9. Long term forecasts to 2050 for the forestry and forest-based industries as seen by the students at the 'Ecole superieure du bois'

    International Nuclear Information System (INIS)

    Groutel, Emmanuel

    2013-01-01

    Some of the engineering students in their 3. year at the Nantes Ecole superieure du bois acquire knowledge through the 'World Forestry Exchanges' scheme. These students - Brazilians, Latvians, Taiwanese, Chines, Tunisian, ... French - learn about forestry flows, wood marketing and product trends. It is against this multi-cultural background that is open and seeks to awaken the students curiosity that their feedback is requested in the form of their own vision of the products and services that should be on offer in the future in many forest-based industries. The diversity of their responses and the originality and relevance of some of these inspired the author to write this article which classifies and summarises these thoughts. This is a cooperative approach which aims at being of educational, academic and practical value. (authors)

  10. Análise ecológica dos acidentes e da violência letal em Vitória, ES

    OpenAIRE

    Bastos,Márcia de Jesus Rocha Pereira; Pereira,Jacira dos Anjos; Smarzaro,Dorian Chim; Costa,Everaldo Francisco; Bossanel,Regina Célia Lobo; Oliosa,Durvalina Maria Sesari; Pereira,Joseanny Gomes Poltronieri; Feitosa,Hideko Nagatani; Costa,Marcilene Favarato da; Oliveira,Fabiano José Pereira de; Fávero,Juliana Lopes; Maciel,Ethel Leonor Noia

    2009-01-01

    OBJETIVO: Analisar o contexto socioeconômico e sua relação com a incidência espacial da mortalidade devido à violência. MÉTODOS: Foi realizado estudo do tipo ecológico no município de Vitória, ES, de 2000 a 2003, sobre a distribuição espacial da mortalidade por acidentes e violência, com base nas informações populacionais e socioeconômicas. Os dados sobre mortalidade foram relacionados a informações como local de residência da vítima, tipo de ocorrência, sexo e raça/cor. A análise das informa...

  11. Análisis de valoración contingente de restauración ecológica de una cantera en Soacha, Cundinamarca, Colombia

    Directory of Open Access Journals (Sweden)

    Lina Melissa Tequia Mayorga

    2016-12-01

    Full Text Available La investigación tuvo como objetivo analizar la disponibilidad a pagar por la realización de la restauración ecológica de la cantera Cueva del zorro, por parte de los habitantes de la vereda Panamá, en el municipio de Soacha, Cundinamarca, Colombia. Metodológicamente se aplicaron encuestas y una entrevista al líder comunitario de la comunidad con el fin de conocer la percepción acerca del ambiente, la restauración y la minería. La información  recopilada fue analizada a través de estadísticas descriptivas. Los resultados muestran que los niveles socio-económicos de la población influyen directamente en la toma de decisiones en cuanto al valor monetario ofrecido para la realización de la restauración.

  12. Amphibians of the Reserva Ecológica Michelin: a high diversity site in the lowland Atlantic Forest of southern Bahia, Brazil.

    Science.gov (United States)

    de Mira-Mendes, Caio Vinícius; Ruas, Danilo Silva; de Oliveira, Renan Manoel; Castro, Indira Maria; Dias, Iuri Ribeiro; Baumgarten, Julio Ernesto; Juncá, Flora Acuña; Solé, Mirco

    2018-01-01

    An inventory of the amphibians of the Reserva Ecológica Michelin - REM in southern Bahia, Brazil is presented. Sixty-nine species were recorded during a ten-year sampling period. Amphibians were distributed in two orders (Gymnophiona and Anura), belonging to twelve families [Aromobatidae (1), Bufonidae (3), Centrolenidae (1), Craugastoridae (5), Eleutherodactylidae (3), Hemiphractidae (2), Hylidae (34), Phyllomedusidae (5) Leptodactylidae (7), Microhylidae (4), Odontophrynidae (3) and Caeciliidae (1)]. Fifty per cent of the reproductive modes known for Atlantic forest anurans were recorded. While no threatened species were found at REM, six species are classified as data deficient (DD) by the Brazilian Red List of threatened species and deserve additional attention. Phasmahyla timbo and Vitreorana eurygnatha are listed as endangered in Bahia according to the list of threatened species of the state. Despite a higher diversity of amphibians in the Atlantic forest having been reported for mountainous regions, our results revealed that amphibian richness for lowland forests is also high.

  13. Crítica ecológica al concepto de Desarrollo y nuevas alternativas desde América Latina

    Directory of Open Access Journals (Sweden)

    Ana Luíza Matos de Oliveira

    2014-12-01

    Full Text Available Este artículo derivado de investigación analiza el concepto de Desarrollo desde sus orígenes, presentando la crítica ecológica a este concepto, en especial por parte de la teoría del decrecimiento, muestra algunas contribuciones de los pueblos originarios a las constituciones de países de tendencia de izquierda en América Latina en los años recientes y problematiza la actual inserción de América Latina en el comercio internacional. Se encontró que contrarrestar a la fuerza económica, política y discursiva del agronegocio y del “progreso”, apoyado en el “desarrollo” no es algo simple. En América Latina hay tensiones entre el concepto de desarrollo convencional e intentos por construir un nuevo camino, un camino latinoamericano. Hay resistencias entre la (reprimarización y la inserción internacional de América Latina, también existen tensiones en el campo, conuna disputa entre el agronegocio como modelo de desarrollo, modernidad y progreso y otras formas de relacionarse con el medio ambiente y con el otro. Se concluye que desde América Latina es posible crear un nuevo camino, no necesariamente en aras de imitar el mundo desarrollado, sino considerando los limites ecológicos y sociales del capitalismo y las contribuciones de los pueblos originarios.

  14. Estado ecológico de algunos humedales colombianos en los últimos 15 años: una evaluación prospectiva

    Directory of Open Access Journals (Sweden)

    Juan Pablo Rodríguez

    2017-06-01

    Full Text Available Los humedales desempeñan un papel fundamental desde una perspectiva ecológica y socioeconómica. Contrario a la idea ya obsoleta de lugares insalubres y de poca productividad, hoy son considerados ecosistemas estratégicos, amortiguadores de crecientes, sitios especiales de conservación de biota y cruciales por los servicios ecosistémicos que prestan. Partiendo de una revisión bibliográfica referente al estado ecológico de los humedales en Colombia en los últimos 15 años, se analizó cuáles son los factores, problemáticas e impactos más frecuentes y comunes que se presentan en 29 humedales colombianos. Se aplicó una metodología prospectiva, mediante el software MICMAC®, con el fin de conocer y priorizar los factores que son más sensibles a la transformación del ecosistema y sobre los cuales habría que tomar acciones de mitigación, preservación y/o conservación. Se encontró que los procesos urbanísticos son un factor de alto impacto en el deterioro del humedal. Se pudo comprobar la potencialidad y robustez del software MICMAC® como herramienta de análisis prospectivo, lo cual podría ser usado por las autoridades ambientales para mejorar la toma de decisiones respecto a qué hacer, cómo actuar y qué esperar de los factores y problemáticas que se presentan en los humedales.

  15. Valoración de impactos ecológicos por minería de oro en río Guabas, Valle del Cauca, Colombia

    Directory of Open Access Journals (Sweden)

    Diego Esteban Gamboa García

    2015-12-01

    Full Text Available La minería de oro es una actividad que se ha desarrollado por siglos en diferentes territorios en el planeta. Sin embargo, la minería ha generado impactos ambientales afectando a la sociedad, debido a que comprometen la cantidad y calidad de los servicios ecosistémicos y en consecuencia, la calidad de vida de la población mundial. Para medir el nivel de afectación sobre los componentes del ambiente, se revisaron los métodos clásicos para Estudios de Impacto Ambiental (EIA para proyectos mineros y se tomó como base la matriz de Leopold desarrollada por el Servicio Geológico del Departamento del Interior de los Estados Unidos, para valorizar los impactos de actividades mineras. En esta investigación se revisaron investigaciones publicadas con las palabras clave “matriz cualitativa” y “minería de oro”, tanto en inglés como en español, desde el año 2000 al 2011, en proyectos mineros realizados en países en vía de desarrollo. Posteriormente, se extrajeron y sistematizaron, las metodologías clásicas y sus variaciones y los componentes ecológicos y actividades del proyecto comunes en los estudios. Las metodologías usadas fueron cualitativas. Adicionalmente, se desarrolló la metodología Valor del Índice Ambiental (VIA para valorizar los impactos ecológicos de la minería de oro en la cuenca del río Guabas, Valle del Cauca, Colombia. Se encontró que el impacto promedio de la actividad minera desarrollada en el río Guabas fue considerado severo, a diferencia del impacto global revisado en la literatura, que fue considerado como moderado, en la mayoría de los casos.

  16. La restauración ecológica participativa: Una visión juvenil desde el territorio de Ciudad Bolívar

    Directory of Open Access Journals (Sweden)

    Shirley Eliana Camacho-Ballesteros

    2016-05-01

    Full Text Available Ciudad Bolívar, una localidad de la ciudad de Bogotá, ha aumentado su población de forma acelerada en las últimas décadas, ya que constituye un centro de confluencia para el asentamiento de las personas que emigran de las zonas rurales, principalmente por la búsqueda de nuevas oportunidades o un refugio contra la violencia y el desplazamiento forzado. Tal situación implica el uso de los recursos naturales y territorios de acuerdo con las necesidades en un corto plazo, así como la falta de planificación en el desarrollo de la localidad, por lo cual se establecen en territorios desprovistos de los ambientes naturales, con una menor calidad de vida y de salud, y problemas constantes que surgen dentro de la población. Sin embargo, la niñez y la juventud que viven en estos entornos complejos surgen de la desesperanza, impulsando alternativas y anhelos como una contribución para mejorar su calidad de vida. Esta joven población constituyen los sujetos principales de este artículo teórico, ya que se enfrentan y proponen el tema de la restauración ecológica participativa como mecanismo de planificación, la memoria y la construcción de mejores condiciones para la vida. Desde su experiencia y punto de vista reflexivo, surge una propuesta sobre dónde y cómo llevar a cabo el proceso de restauración ecológica, como una suma de acciones para el fortalecimiento de los valores territoriales y ambientales.

  17. Crisis y nuevos patrones de consumo: discursos sociales acerca del consumo ecológico en el ámbito de las grandes ciudades españolas.

    Directory of Open Access Journals (Sweden)

    Luis Enrique Alonso

    2014-01-01

    Full Text Available La situación de profunda crisis económica que atraviesa España desde hace varios años está teniendo efectos significativos en las formas de relación de la ciudadanía con las prácticas de consumo. Una de las cuestiones más relevantes en este contexto tiene que ver con la posibilidad de un crecimiento de la con - ciencia medioambiental, ante la dificultad creciente para sostener los patrones consumistas de la época del boom, la popularización de nuevas pautas de con - sumo responsable y la creciente preocupación en relación a fenómenos como el cambio climático. En este artículo, nuestro objetivo específico es el de explorar las percepciones sociales en relación al denominado consumo ecológico, desde una perspectiva fundamentalmente cualitativa. Para ello, procederemos a realizar un análisis de los discursos generados en una serie de grupos de discusión, en el marco de una investigación más amplia sobre la relación entre consumo y crisis. Los resultados obtenidos parecen apuntar hacia las dificultades que presentan las opciones de consumo ecológicas de consolidarse en el imaginario del consumi - dor medio español, debido a una serie de razones que se describirán con detalle en nuestro trabajo

  18. Características bio-ecológicas en poblaciones de lombrices (Oligochaeta: Glossoscolecidae de una sabana natural y una protegida en los llanos centrales de Venezuela

    Directory of Open Access Journals (Sweden)

    Luis Hernández

    2012-09-01

    Full Text Available Las lombrices de tierra tienen un papel importante en el ciclado de nutrientes y el mantenimiento de la fertilidad de los suelos. En este estudio se empleo el método de extracción manual para determinar la densidad y la biomasa de las lombrices de tierra en diferentes profundidades y en diferentes estaciones, seleccionando al azar cinco monolitos de 25cm2x30cm, ubicados en un área de 90x90m en una Sabana Protegida (SP y una Sabana Natural Intervenida (SNI. Adicionalmente, se estimó la densidad de los capullos, se analizaron las clases de etapas de desarrollo y se clasificaron los individuos en categorías ecológicas. Se estimó la humedad del suelo, la capacidad de campo, la temperatura, la densidad aparente y la textura del suelo. La SP presentó mejores condiciones físicas en el suelo que la SNI, mientras que la actividad de las lombrices de tierra estuvo limitada a los meses de lluvia y se observó un patrón de migración estacional en el perfil del suelo. En la SNI sólo se observó presencia de individuos en agosto y no se encontró diferencia significativa en sus biomasas con la SP. Los sistemas estuvieron dominados por individuos jóvenes con una categoría ecológica de tipo endo-anécica pertenecientes a la familia

  19. Concepções de agricultores ecológicos do Paraná sobre alimentação saudável

    Directory of Open Access Journals (Sweden)

    Erica Ell

    2012-04-01

    Full Text Available OBJETIVO: Descrever as concepções de agricultores ecológicos sobre alimentação saudável. MÉTODOS: Estudo com abordagem qualitativa. Entre janeiro e fevereiro de 2007, foram realizadas entrevistas em profundidade com o apoio de um roteiro com 11 mulheres e um homem residentes em comunidade agrícola de Rio Branco do Sul, PR, selecionados aleatoriamente dentre as 20 famílias de agricultores ecológicos desse município. RESULTADOS: Três categorias de análise foram identificadas: "tomada de consciência da alimentação saudável", "capacidade de compra" e "terra saudável". O significado da alimentação saudável para as mulheres agricultoras envolve a ideia de que os alimentos devem ser naturais, sem agrotóxicos nem produtos químicos industrializados. Cotidianamente o consumo de frutas, verduras e legumes somado ao básico feijão, arroz e carne deve ser abundante e a composição do prato deve visar à prevenção de obesidade e doenças crônico-degenerativas. O cuidado com os recursos naturais para garantir a produção de alimentos saudáveis, a segurança alimentar, a sustentabilidade do meio ambiente e a vida futura do planeta integram o conceito de alimentação saudável. CONCLUSÕES: O conhecimento, a autocrítica e o discernimento acompanharam as concepções em relação à alimentação saudável.

  20. Conhecimento ecológico tradicional sobre plantas cultivadas pelos pescadores da comunidade Estirão Comprido, Pantanal matogrossense, Brasil

    Directory of Open Access Journals (Sweden)

    Fernando Ferreira de Morais

    Full Text Available Esta pesquisa situa-se no campo da etnoecologia e aborda o conhecimento ecológico tradicional (CET sobre plantas cultivadas na comunidade de Estirão Comprido, rio Cuiabá, Barão de Melgaço, Pantanal matogrossense. Foram entrevistados 22 pescadores para a elaboração da lista livre de plantas. Para a análise da lista, foram utilizados: índice de saliência de Smith, análise de consenso cultural, similaridade e dissimilaridade com escalonamento multidimensional e técnica de empilhamento. O programa ANTHROPAC 4.0 foi utilizado para o tratamento estatístico dos dados. Por meio do índice de saliência de Smith, foram identificadas seis rupturas no domínio cultural sobre plantas cultivadas, concentrando-se em 116 etnoespécies. Laranja e milho foram citados com maior frequência e em primeiro lugar na lista, portanto, encontram-se na primeira ruptura da lista livre com índices de Smith 0,728 e 0,711, respectivamente. A análise de consenso cultural mostrou que o CET sobre plantas cultivadas caracteriza um consenso, concentrando-se em 18 etnoespécies. A análise de empilhamento evidenciou que o conhecimento sobre plantas está relacionado aos diferentes tipos de uso. Neste contexto, as possibilidades de uso e manejo aqui evidenciadas podem contribuir para a elaboração de políticas públicas destinadas à conservação da biodiversidade ecológica e cultural.

  1. Prostorové rozhraní informačního systému malé obce řešené v Open Source Software

    Directory of Open Access Journals (Sweden)

    Karel Jedlička

    2006-12-01

    Full Text Available Příspěvek si klade za cíl představit možnosti open source software pro implementaci prostorového rozhraní informačního systému malé obce.Zabývá se návrhem projektu po jednotlivých částech: identifikace požadavků zastupitelského úřadu (uživatele systému, popis obecné architektury systému a volba vhodných (nekomerčních technologií pro jeho implementaci. Součástí projektu je i popis vyvinuté technologie pro import nejdůležitějších datových vrstev (informací o vlastnictví do systému.Článek je doplněn výčtem využitelných datových zdrojů pro informační systém malé obce v České republice.

  2. Systém na automatické generování písemných zkoušek

    OpenAIRE

    Kapusta, Vlastimil

    2013-01-01

    Tato bakalářská práce popisuje grafický návrh, použité technologie a implementaci systému na automatické generování písemných zkoušek. Jako implementační jazyk byl použit jazyk Java. Práce se zabývá použitím knihovny Swing pro tvorbu GUI a využitím knihoven Insubstantial a SwingX, které rozšiřují knihovnu Swing. Důležitou částí práce je propojení jazyka Java a sázecího systému LaTeX. Výsledkem je aplikace, která umožňuje vytváření zadání písemných zkoušek. Dále je umožněno ukládání a načítání...

  3. Système de PLC pour la supervision de la distribution basse tension des expériences ALICE et LHCb

    CERN Document Server

    Burdet, G

    2004-01-01

    Le groupe TS/EL étudie et réalise la distribution électrique basse tension pour alimenter les racks contenant l'électronique associée aux détecteurs dans les zones expérimentales du LHC. La distribution basse tension utilisera des tableaux récupérés des expériences du LEP pour ALICE et LHCb et un système basé sur des gaines CANALIS pour ATLAS et CMS. L'ensemble de la distribution électrique basse tension sera surveillée et contrôlée par l'intermédiaire de systèmes à base de PLC. Ce papier décrit l'infrastructure de supervision proposée pour ALICE et LHCb et son intégration au CERN Electrical Network Supervisor (ENS) et au Detector Control System (DCS).

  4. Návrhové systémy používané v oblasti elektrických přístrojů

    OpenAIRE

    Stejskal, Jiří

    2008-01-01

    Bakalářská práce je vypracována na základě požadavků zadavatele firmy OEZ, s.r.o. a je rozdělena na dvě části. První část práce se zabývá nejčastěji používanými 2D CAD systémy, které používají konstruktéři, dle svých odpovědí v oblasti návrhu elektrických rozvaděčů nn. V práci jsou popsány hlavní možnosti těchto systémů, dále pak jaké datové formáty jsou jimi podporovány. V druhé části práce jsou popsány programy určené k výpočtu oteplení rozváděčů. Jedná se jednak o programy, které dodává ko...

  5. Systém pro obchodování s virtuálními předměty

    OpenAIRE

    Sedláček, Lukáš

    2007-01-01

    Cílem této práce je seznámit čtenáře s problematikou systémů pro obchodování s virtuálními předměty. Práce je zaměřena hlavně na virtuální ekonomiky MMORPG (Massive(ly)-Multiplayer Online Role-Playing Game). Pro hlubší pochopení MMORPG světů, je v této práci zpracován jejich vznik, vývoj, historie, psychologické aspekty, náhled do problematiky jejich virtuálních ekonomik, stručná charakteristika elektronických platebních systémů a informace o dvou virtuálních ekonomikách (Entropia Universe a ...

  6. Diversity as a General Basis of Tourism – System Approach/ Diverzita Jako Základ Turizmu – Systémový Přístup

    Directory of Open Access Journals (Sweden)

    Schejbal Ctirad

    2015-03-01

    Full Text Available Obecným základem turizmu je diverzita přírodního a antropogenního prostředí. diverzitu lze považovat za přirozenou vlastnost přírodních a antropogenních systémů, kterou si samy vytvářejí, jakožto podmínku svého setrvání a rozvoje na všech úrovních. Při posuzování turizmu lze vymezit geodiverzitu, biodiverzitu a socioekonomickou diverzitu, jejíž součástí je technologická diverzita. Geodiverzita a biodiverzita představuje spolu s trechnologickou diverzitou základ geovědního a montánního turizmu. V případě biodiverzity je z hlediska turizmu důležitá především regionální diverzita a strukturní diverzita, které lze paralelizovat s geotopem a geofenoménem. Cílem je poukázat na nutnost systémového přístupu k analýze turizmu jako komplexního jevu se složitou strukturou.

  7. Equilibres de phases dans les systèmes fluides petroliers-eau Phase Equilibria in Oil-Water Systems

    Directory of Open Access Journals (Sweden)

    Peneloux A.

    2006-11-01

    Full Text Available Nous présentons quelques résultats obtenus à partir du logiciel FHYD qui permet le traitement des mélanges eau-fluides pétroliers, avec la détermination de la nature des phases (huile-gaz-eau-hydrate thermodynamiquement stables dans des conditions données de température et de pression, ainsi que de la quantité, de la composition de ces différentes phases et de leurs propriétés. Ce logiciel permet le tracé automatique des diagrammes de phases et nous présentons des exemples, depuis les systèmes binaires (eau-éthane, ternaires (eau-méthane-propane jusqu'aux fluides les plus complexes. La présence de sels (chlorure de sodium dissous est envisagée, ainsi que le calcul des conditions de dépôt du sel solide. Des exemples de problèmes pétroliers sont cités (gaz de séparateur saturé en eau, huile saturée en eau dans les conditions de gisement, huile en présence d'eau salée. Les estimations sur les quantités d'hydrate formées et leurs compositions sont comparées à des données expérimentales et aux résultats obtenus par d'autres logiciels. Le programme FHYD pourrait permettre une représentation plus réaliste de l'évolution des fluides pétroliers et des propriétés de transport de leurs différentes phases dans les modèles de simulation des conduites polyphasiques. This article presents a selection of results obtained with the FHYD program. This software allows simulation of mixtures composed of petroleum fluids and water, with determination of the nature of thermodynamically stable phases (oil-gas-water-hydrate under given conditions of temperature and pressure, along with the quantity, composition and properties of these different phases. Additionally, the program can automatically produce phase diagrams. Several examples of these have been included here, ranging from binary systems (water-ethane and ternary systems (water-methane-propane to the most complex petroleum fluids. The presence of dissolved salts

  8. hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Li Ziqiang; Zhang Hong; McManus, Terrence P.; McCormick, J. Justin; Lawrence, Christopher W.; Maher, Veronica M

    2002-12-29

    In S. cerevisiae, the REV3 gene, encoding the catalytic subunit of polymerase zeta, is involved in translesion synthesis and required for the production of mutations induced by ultraviolet radiation (UV) photoproducts and other DNA fork-blocking lesions, and for the majority of spontaneous mutations. To determine whether hREV3, the human homolog of yeast REV3, is similarly involved in error-prone translesion synthesis past UV photoproducts and other lesions that block DNA replication, an hREV3 antisense construct under the control of the TetP promoter was transfected into an infinite life span human fibroblast cell strain that expresses a high level of tTAk, the activator of that promoter. Three transfectant strains expressing high levels of hREV3 antisense RNA were identified and compared with their parental cell strain for sensitivity to the cytotoxic and mutagenic effects of UV. The three hREV3 antisense-expressing cell strains were not more sensitive than the parental strain to the cytotoxic effect of UV, but the frequency of mutants induced by UV in their HPRT gene was significantly reduced, i.e. to 14% that of the parent. Two of these hREV3 antisense-expressing cell strains were compared with the parental strain for sensitivity to ({+-})-7{beta},8{alpha}-dihydroxy-9{alpha},10{alpha}-epoxy-7,8,9,10-tetrahydro= benzo[a]pyrene (BPDE). They were not more sensitive than the parent strain to the cytotoxic effect of BPDE, but the frequency of mutants induced was significantly reduced, i.e. in one strain, to 17% that of the parent, and in the other, to 24%. DNA sequencing showed that the kinds of mutations induced by BPDE in the parental and the derivative strains did not differ and were similar to those found previously with finite life span human fibroblasts. The data strongly support the hypothesis that hRev3 plays a critical role in the induction of mutations by UV or BPDE. Because the level of hRev3 protein in human fibroblasts is below the level of antibody

  9. hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts

    International Nuclear Information System (INIS)

    Li Ziqiang; Zhang Hong; McManus, Terrence P.; McCormick, J. Justin; Lawrence, Christopher W.; Maher, Veronica M.

    2002-01-01

    In S. cerevisiae, the REV3 gene, encoding the catalytic subunit of polymerase zeta, is involved in translesion synthesis and required for the production of mutations induced by ultraviolet radiation (UV) photoproducts and other DNA fork-blocking lesions, and for the majority of spontaneous mutations. To determine whether hREV3, the human homolog of yeast REV3, is similarly involved in error-prone translesion synthesis past UV photoproducts and other lesions that block DNA replication, an hREV3 antisense construct under the control of the TetP promoter was transfected into an infinite life span human fibroblast cell strain that expresses a high level of tTAk, the activator of that promoter. Three transfectant strains expressing high levels of hREV3 antisense RNA were identified and compared with their parental cell strain for sensitivity to the cytotoxic and mutagenic effects of UV. The three hREV3 antisense-expressing cell strains were not more sensitive than the parental strain to the cytotoxic effect of UV, but the frequency of mutants induced by UV in their HPRT gene was significantly reduced, i.e. to 14% that of the parent. Two of these hREV3 antisense-expressing cell strains were compared with the parental strain for sensitivity to (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). They were not more sensitive than the parent strain to the cytotoxic effect of BPDE, but the frequency of mutants induced was significantly reduced, i.e. in one strain, to 17% that of the parent, and in the other, to 24%. DNA sequencing showed that the kinds of mutations induced by BPDE in the parental and the derivative strains did not differ and were similar to those found previously with finite life span human fibroblasts. The data strongly support the hypothesis that hRev3 plays a critical role in the induction of mutations by UV or BPDE. Because the level of hRev3 protein in human fibroblasts is below the level of antibody detection, it was not

  10. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells

    Energy Technology Data Exchange (ETDEWEB)

    Morioka, Norimitsu, E-mail: mnori@hiroshima-u.ac.jp; Tomori, Mizuki; Zhang, Fang Fang; Saeki, Munenori; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro

    2016-01-08

    Under physiological conditions, astrocytes maintain homeostasis in the CNS. Following inflammation and injury to the CNS, however, activated astrocytes produce neurotoxic molecules such as cytokines and chemokines, amplifying the initial molecular-cellular events evoked by inflammation and injury. Nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammation- and metabolism-related gene transcription. The current study sought to elucidate a role of REV-ERBs in rat C6 astroglial cells on the expression of inflammatory molecules following stimulation with the neuroinflammatory cytokine tumor necrosis factor (TNF). Stimulation of C6 cells with TNF (10 ng/ml) significantly increased the mRNA expression of CCL2, interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and matrix metalloprotease (MMP)-9, but not fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (COX-2) and MMP-2. Treatment with either REV-ERB agonists GSK4112 or SR9009 significantly blocked TNF-induced upregulation of CCL2 mRNA and MMP-9 mRNA, but not IL-6 mRNA and iNOS mRNA expression. Furthermore, treatment with RGFP966, a selective histone deacetylase 3 (HDAC3) inhibitor, potently reversed the inhibitory effects of GSK4112 on TNF-induced expression of MMP-9 mRNA, but not CCL2 mRNA. Expression of Rev-erbs mRNA in C6 astroglial cells, primary cultured rat cortical and spinal astrocytes was confirmed by reverse transcription polymerase chain reaction. Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 and CCL2 transcription, of astroglial REV-ERBs activation through HDAC3-dependent and HDAC3-independent mechanisms. - Highlights: • Rev-erbα mRNA and Rev-erbβ mRNA are expressed in C6 astroglial cells. • TNF increases the expression of CCL2, IL-6, MMP-9 and iNOS mRNA. • REV-ERB activation inhibits CCL2 mRNA and MMP-9 mRNA expression. • HDAC3 activity is involved in the inhibitory effect of REV-ERB on MMP-9 induction.

  11. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells

    International Nuclear Information System (INIS)

    Morioka, Norimitsu; Tomori, Mizuki; Zhang, Fang Fang; Saeki, Munenori; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro

    2016-01-01

    Under physiological conditions, astrocytes maintain homeostasis in the CNS. Following inflammation and injury to the CNS, however, activated astrocytes produce neurotoxic molecules such as cytokines and chemokines, amplifying the initial molecular-cellular events evoked by inflammation and injury. Nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammation- and metabolism-related gene transcription. The current study sought to elucidate a role of REV-ERBs in rat C6 astroglial cells on the expression of inflammatory molecules following stimulation with the neuroinflammatory cytokine tumor necrosis factor (TNF). Stimulation of C6 cells with TNF (10 ng/ml) significantly increased the mRNA expression of CCL2, interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and matrix metalloprotease (MMP)-9, but not fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (COX-2) and MMP-2. Treatment with either REV-ERB agonists GSK4112 or SR9009 significantly blocked TNF-induced upregulation of CCL2 mRNA and MMP-9 mRNA, but not IL-6 mRNA and iNOS mRNA expression. Furthermore, treatment with RGFP966, a selective histone deacetylase 3 (HDAC3) inhibitor, potently reversed the inhibitory effects of GSK4112 on TNF-induced expression of MMP-9 mRNA, but not CCL2 mRNA. Expression of Rev-erbs mRNA in C6 astroglial cells, primary cultured rat cortical and spinal astrocytes was confirmed by reverse transcription polymerase chain reaction. Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 and CCL2 transcription, of astroglial REV-ERBs activation through HDAC3-dependent and HDAC3-independent mechanisms. - Highlights: • Rev-erbα mRNA and Rev-erbβ mRNA are expressed in C6 astroglial cells. • TNF increases the expression of CCL2, IL-6, MMP-9 and iNOS mRNA. • REV-ERB activation inhibits CCL2 mRNA and MMP-9 mRNA expression. • HDAC3 activity is involved in the inhibitory effect of REV-ERB on MMP-9 induction.

  12. PSICAMB: perfil de afinidade ecológica: um estudo sobre os indicadores da postura perante a natureza = Ecological affinity profile: a study on indicators of positions towards nature = Perfil de la conectividad ecológica: un estudio sobre los indicadores de posicionamiento frente a la naturaleza

    Directory of Open Access Journals (Sweden)

    Rosa, Daniele da Costa Cunha Borges

    2015-01-01

    Full Text Available O presente estudo teve o objetivo de propor indicadores de um perfil de afinidade ecológica, avaliar sua relação com a importância dedicada à floresta amazônica e com a consideração do efeito das ações humanas na natureza. Participaram deste estudo 345 sujeitos, de ambos os sexos, com idade superior a 18 anos, das cidades de Manaus – AM e Ceres – GO. Os instrumentos deste estudo são compostos por escalas, que mediram dimensões cognitivas e afetivas na relação com a floresta amazônica e com a natureza no geral. Para análise dos dados foram realizadas análises fatoriais exploratórias, regressões e análises de estrutura de similaridade. Os resultados indicaram que ao avaliar as relações de afeto para com a natureza, as crenças em relação ao ambiente natural e a consideração de consequências futuras é possível identificar uma estrutura que engloba um perfil de afinidade ecológica e um perfil utilitarista

  13. Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities

    International Nuclear Information System (INIS)

    2000-05-01

    This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licencee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection

  14. Evolution of ASTEC V1.2 rev.1 code for WWER-1000 reactors/SBO sequence

    International Nuclear Information System (INIS)

    Georgieva, J.; Stefanova, A.; Groudev, P.; Tusheva, P.; Kalchev, B.; Passalacqua, R.

    2006-01-01

    In this paper a comparison between calculations of severe accidents occurred from WWER-1000 with ASTEC code specified for an event of full unloading with relief valves stuck opened with no hydroaccumulators intervention is presented. The purpose of the analyses provided is to present the relationship between the improvements of the actual version (ASTEC Vl.2 rev. 1) and ASTEC V1.1 p2 like: code modifications, incoming data improvements. Such discrepancies are to be examined. Case by case suggestions for ASTEC improvements are to be provided

  15. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-15

    As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind

  16. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

    International Nuclear Information System (INIS)

    2002-10-01

    As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind farm

  17. Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities

    International Nuclear Information System (INIS)

    2002-05-01

    This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licensee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection

  18. Uma tentativa de caracterização da economia ecológica Outlines for a definition of ecological economics

    Directory of Open Access Journals (Sweden)

    Clóvis Cavalcanti

    2004-06-01

    Full Text Available Partindo do reconhecimento de que toda atividade humana incide no ecossistema quer pelo lado da extração de recursos, quer pelo do lançamento de dejetos sob a forma de matéria ou energia degradada, o processo econômico - que opera dentro de um subsistema aberto envolvido pelo ecossistema global - tem que respeitar limites. Daí, a noção de desenvolvimento sustentável. Na perspectiva da sustentabilidade, o tipo de processo econômico que importa é aquele que produz bens e serviços considerando simultaneamente todos os custos (ou males que lhes são inevitavelmente associados. Esta é a tarefa para um modelo de desenvolvimento novo, e também para uma ciência da economia de fundamentos ecológicos. É aqui que se insere a economia ecológica, com a qual se introduz uma mudança fundamental na percepção dos problemas de alocação de recursos e de como eles devem ser tratados, do mesmo modo que uma revisão da dinâmica do crescimento econômico. Visa-se com o empreendimento obter a unificação sobre bases biofísicas dos sistemas ecológicos e econômicos como categorias interdependentes e coevolutivas. Não se trata de propor uma nova ciência, e sim uma empreitada (ou cometimento entre cientistas naturais e sociais, junto com os atores envolvidos em ações concretas de promoção do desenvolvimento, para chegar-se a novo entendimento da realidade humana, tirando dele lições para fins de análise e política. Chega-se assim a uma verdadeira economia política da ecologia.Considering that all human activity interacts with the environment either by extracting resources or by discarding trash under the form of degraded matter and energy, the economic process - which operates within an open subsystem contained by the global ecosystem - has to observe limits. Hence, the notion of sustainable development. In the perspective of sustainability, the kind of economic process which matters is that which produces goods and services taking

  19. Binding mode prediction and MD/MMPBSA-based free energy ranking for agonists of REV-ERBα/NCoR.

    Science.gov (United States)

    Westermaier, Yvonne; Ruiz-Carmona, Sergio; Theret, Isabelle; Perron-Sierra, Françoise; Poissonnet, Guillaume; Dacquet, Catherine; Boutin, Jean A; Ducrot, Pierre; Barril, Xavier

    2017-08-01

    The knowledge of the free energy of binding of small molecules to a macromolecular target is crucial in drug design as is the ability to predict the functional consequences of binding. We highlight how a molecular dynamics (MD)-based approach can be used to predict the free energy of small molecules, and to provide priorities for the synthesis and the validation via in vitro tests. Here, we study the dynamics and energetics of the nuclear receptor REV-ERBα with its co-repressor NCoR and 35 novel agonists. Our in silico approach combines molecular docking, molecular dynamics (MD), solvent-accessible surface area (SASA) and molecular mechanics poisson boltzmann surface area (MMPBSA) calculations. While docking yielded initial hints on the binding modes, their stability was assessed by MD. The SASA calculations revealed that the presence of the ligand led to a higher exposure of hydrophobic REV-ERB residues for NCoR recruitment. MMPBSA was very successful in ranking ligands by potency in a retrospective and prospective manner. Particularly, the prospective MMPBSA ranking-based validations for four compounds, three predicted to be active and one weakly active, were confirmed experimentally.

  20. REMINDER: Compliance with Operational Circular No. 2 (Rev. 1) on “Conditions of access to the fenced CERN site”

    CERN Multimedia

    2012-01-01

    The purpose of Operational Circular No. 2 (Rev. 1) is to contribute to the protection of people and property by defining the conditions of access to the Organization's fenced sites. The behaviours that cannot be tolerated under any circumstances are: use of CERN access cards by people, other than the cardholders themselves, in order to gain access to facilities without having attended the required safety course; speeding, particularly on Route Gregory and Route Weisskopf; driving in and out of the site on the wrong side of the road; parking on spaces set aside for the disabled; nuisance parking, especially in the proximity of the restaurants; dumping of wrecked vehicles. As the aforementioned instances of non-compliance can lead to dangerous situations, the Organization reserves the right to apply the penalties provided for under paragraph 26 of Operational Circular No. 2 (Rev. 1), namely to refuse access to the site to people and/or their vehicles deemed to be in infringement of the circu...

  1. Indicadores ecológicos de hábitat y biodiversidad en un paisaje neotropical: perspectiva multitaxonómica

    Directory of Open Access Journals (Sweden)

    Noel González-Valdivia

    2011-09-01

    Full Text Available El uso de especies indicadoras para caracterizar unidades ecológicas específicas es de gran importancia en la biología de la conservación/restauración. El objetivo del estudio fue identificar desde una perspectiva multitaxonómica, las especies que caracterizan distintas unidades de un paisaje. Así, se diferenciaron dos ecomosaicos: bosque tropical lluvioso y matriz agropecuaria con cuatro unidades de paisaje cada uno. Se incluyeron cuatro grupos biológicos: aves (muy móviles, mariposas frugívoras diurnas (moderadamente móviles, gasterópodos terrestres (poco móviles y árboles (sésiles. La eficiencia de muestreo en los ecomosaicos fue ≥86%. Se registraron 50 especies de moluscos, 74 de mariposas, 218 de aves y 172 de árboles, totalizando 514 especies. Mediante ordenamiento y agrupamiento, se diferenciaron tres tipos de hábitats: bosque tropical lluvioso, vegetación secundaria y potreros con árboles. Aplicando el método InVal (≥50%, se identificaron 107 especies indicadoras, de las cuales 45 fueron árboles, 38 aves, 14 mariposas y diez gasterópodos. De éstas, 35 especies de árboles, diez de aves, cuatro de mariposas y ocho de gasterópodos son indicadoras del bosque. Diez, veintiocho, diez y dos especies (de cada grupo respectivamente caracterizaron a la matriz agropecuaria. En el bosque, los gasterópodos Carychium exiguum, Coelocentrum turris, Glyphyalinia aff. indentata y Helicina oweniana se correlacionaron significativamente (p<0.05 con 90% de las especies indicadoras. Estos gasterópodos pueden, además de diferenciar la calidad del hábitat, ser indicadoras de la biodiversidad del bosque. La vegetación secundaria representó una fase intermedia de perturbación que propicia alta riqueza en la matriz agropecuaria. De manera que se aporta una perspectiva multitaxonómica que incluye el papel de la mesofauna en el monitoreo ecológico de agropaisajes.

  2. A problemática ecológica na visão de trabalhadores hospitalares The ecological debate from the hospital workers'standpoint

    Directory of Open Access Journals (Sweden)

    Silviamar Camponogara

    2011-08-01

    Full Text Available Estudo que objetiva conhecer o que pensam os trabalhadores hospitalares sobre a problemática ecológica, buscando subsídios que possam fomentar uma discussão sobre o desenvolvimento de ações responsáveis, por parte destes sujeitos, no contexto do trabalho hospitalar. O referencial teórico utilizado para discussão está assentado na concepção de Sociedade de Risco e Modernidade Reflexiva, defendida por sociólogos contemporâneos. Pesquisa de abordagem qualitativa, utilizando a estratégia do estudo de caso, realizada junto a trabalhadores hospitalares, de uma instituição pública. Os dados foram coletados por meio de análise documental, observação de campo e entrevista individual e coletiva. O estudo revela que o trabalhador hospitalar possui uma visão de distanciamento com relação à questão ambiental, sendo, reflexivamente, afetado pela atual problemática ecológica. Esta concepção também sofre influência de fatores específicos do contexto de trabalho hospitalar. Conclui-se pela importância de ações educativas junto aos trabalhadores, no sentido de buscarem-se ações mais responsáveis em relação à preservação ambiental.This study seeks to ascertain what hospital workers think about the ecologic debate, looking for opinions that may elicit a discussion about the development of responsible actions to be taken by this group in the context of hospital work. The theoretical benchmark used for this discussion is based on the Reflexive Modernization and the Risk Society concept proposed by contemporary sociologists. This involved qualitative research using case study strategy and it was carried out with hospital workers at a public institution. The data were collected using document analysis, field observation and individual and group interviews. The study revealed that hospital workers take a somewhat distant view in terms of the environmental issue, which is reflexively affected by the current ecological debate

  3. Cuestionario para calcular la Huella Ecológica de estudiantes universitarios mexicanos y su aplicación en el Campus Zaragoza de la Universidad Nacional

    Directory of Open Access Journals (Sweden)

    José Manuel Ibarra-Cisneros

    2014-01-01

    Full Text Available En este trabajo se desarrolló un cuestionario de 30 preguntas para calcular la huella ecológica (HE de estudiantes universitarios mexicanos, considerando el estilo de vida y el patrón de consumo propios de la cultura mexicana. Primero, se obtuvo de anuarios estadísticos la productividad promedio (en ton/ha/año, de los bienes agropecuarios y pesqueros más demandados, y de papel de cuadernos escolares, con la finalidad de determinar la superficie que se requiere para producir el consumo anual del mexicano promedio, por tipo de bien; también, se calculó el área promedio para absorber el dióxido de carbono generado por el consumo de energía directo (debido al uso de transportes, de equipos electrónicos, de agua caliente para ducharse y de agua potable de empleo cotidiano, e indirecto (producción, distribución y comercialización de productos. Posteriormente, se transformaron las superficies obtenidas a hectáreas globales (hag mediante factores de conversión y se aplicó el cuestionario a 125 alumnos universitarios obteniendo una HE de 1.48 hag, con resultado de mayor impacto ambiental individual al rubro de alimentos (0.42 hag por el consumo de cárnicos, seguido del uso de energía (0.35 hag, principalmente por utilizar gas LP en la ducha cotidiana. Esta HE está dentro de los límites de sustentabilidad global (< 1.61 hag. No hubo diferencias significativas debidas al nivel de estudios, edad o sexo de la muestra. Finalmente, se concluye que el instrumento desarrollado es coherente con los resultados obtenidos de cuestionarios disponibles en línea y elaborados en países de alto nivel de consumo de bienes y servicios y que aquí se presenta la primera calculadora de huella ecológica que toma en cuenta la idiosincrasia mexicana.

  4. Ações sustentáveis para concepção de loteamentos ecológicos um Estudo de caso da Empresa Ellenco.

    Directory of Open Access Journals (Sweden)

    Odair de Almeida Ferreira

    2015-08-01

    Full Text Available A preocupação com o meio ambiente, e também com os processos produtivos das empresas de modo geral, devido as grandes emissões de agentes poluidores na atmosfera e recursos hídricos, vem prejudicando a flora, fauna e comprometendo a qualidade de vida das pessoas, e afetando todo o eco sistema e a sobrevivência do nosso planeta. Isso tem levado muitos consumidores a repensarem em seus hábitos, optando muitas vezes em adquirir e consumir produtos que possuem práticas em pró a preservação do planeta, diversas empresas atentas a essas mudanças comportamental, e de fato comprometida com as práticas sustentáveis, tem realizados nos últimos anos mudanças na concepção de seus produtos contemplando ações ecológicas. Dessa forma, a proposta deste artigo é discutir as ações possíveis de serem implantadas pelas loteadoras em seus residenciais, de forma que possa tornar os empreendimentos compatíveis aos conceitos de sustentabilidade. A metodologia utilizada foi à bibliográfica por meio do método dedutivo, e também será baseada nas experiências da empresa Ellenco Empreendimentos Imobiliários Ltda, uma loteadora, a qual se destina em implantar projetos residenciais no estado de São Paulo, com o objetivo de identificação da concepção de loteamento com características sustentáveis da empresa. Por tanto, o objetivo da pesquisa é de apresentar as ações necessárias para a concepção de um loteamento sustentável. Em consonância com a bibliografia que trata do tema, e mais as análises de observação da empresa loteadora, foi possível identificar um conjunto de 18 ações em pró a sustentabilidade as quais poderão ser implantadas em um residencial. Chegando de forma consistente aos cumprimentos do objetivo e problemática da pesquisa, uma vez que a preocupação ao meio ambiente é uma necessidade real e deve ser consideras por todas as empresas, e também, considerando a existência de um nicho de mercado disposto

  5. Mudanças sociais e gestão ecológica em questão: a experiência de mamirauá

    Directory of Open Access Journals (Sweden)

    Edila Arnaud Ferreira Moura

    2012-08-01

    Full Text Available Estudo sobre as mudanças sociais que envolveram as populações tradicionais desde a criação de uma unidade de conservação ambiental, no ano de 1990, na região do Médio Solimões, Amazônia brasileira, com o interesse de conservar uma área reconhecida como o maior ecossistema de várzea do mundo. A análise situa os produtores locais em relação ao mercado ecológico e aos agentes do desenvolvimento sustentável. O estudo se refere a 49 localidades da floresta alagada amazônica, com informações relativas aos anos de 1991 a 2006. A análise identifica os agentes sociais que integram o campo socioambiental que se constrói com as políticas de intervenção socioambiental.Estudio sobre los cambios sociales que involucran a las poblaciones tradicionales mediante la creación de un ambiente protegido, en 1990, en el rio Solimões, Amazonia brasileña, en interés de la conservación de una zona reconocida como el ecosistema de humedal más grande del mundo . El análisis es los productores locales para el mercado y los agentes de desarrollo sostenible ecológico. El estudio se refiere a 49 ciudades en la selva amazónica inundada, que abarca los años 1991 a 2006. El análisis identifica los agentes sociales que integran el ámbito del medio ambiente, que se construye con políticas de intervención socioambiental.Study on the social changes involving traditional population after the creation, in 1990, of an environmental conservation unit in the Mid-Solimões River, Brazilian Amazon aimed to conserve an area known as the largest wetland ecosystem in the world. The analysis places local producers in relation to the ecological market and agents of sustainable development. The study covers 49 localities of the Amazon flooded forest, with information obtained between 1991 and 2006. The analysis identifies the social agents who integrate the socio environmental field constructed with social environmental intervention policies.

  6. Levantamento Preliminar da Avifauna do Parque Ecológico do Basalto no Município de Araraquara/SP

    Directory of Open Access Journals (Sweden)

    Alexandre Uehara do Carmo

    2015-01-01

    Full Text Available O processo de urbanização vem modificando de maneira drástica a fisionomia dos ecossistemas, restando apenas pequenos fragmentos de áreas verdes, como praças, parques e terrenos baldios. Nesses ambientes ocorreu a redução dos recursos disponíveis para a manutenção da fauna e flora. O levantamento qualitativo da avifauna é uma interessante ferramenta para a avaliação de condições ambientais, pois, são suscetíveis a variações nos ecossistemas, devido ao alto grau de especificidade por espécie, no que diz respeito a território e habitat. Este levantamento teve por finalidade estabelecer uma lista preliminar da diversidade avifaunística do Parque Ecológico do Basalto, situado na região sudeste do Município de Araraquara-SP, obtendo importantes informações para o manejo e preservação da avifauna e para o seu estado de conservação. O levantamento ocorreu entre os meses de janeiro e outubro de 2005, totalizando 94 horas de observação. Foi utilizado o método de transecto onde, através de um percurso pré-determinado e com o auxílio de binóculos 7x35 e 10x50 e de fotografias e vocalizações registradas em campo e guias de campo, registramos 84 espécies de aves distribuídas em 28 famílias pertencentes a 13 ordens. Dentre estas aves registradas, 09 foram avistadas apenas sobrevoando o parque, ao contrário das outras 75 que foram vistas se alimentando e ou nidificando (16 dentro do parque. Para melhor explicitação dos dados, separamos as espécies nas seguintes guildas: fugívoras (13, insetívoras (44, nectívoras (04, carnívoras (06, granívoras (04, detritívoras (01 e onívoras (12. Esses dados preliminares revelam a importância da conservação do Parque Ecológico do Basalto para a manutenção das avifaunas que o adotaram como refúgio, por possuir os recursos como alimento, abrigo e locais para reprodução, em meio à urbanização e crescimento horizontal da cidade de Araraquara.

  7. Estructura y daños en las comunidades de octocorales (Octocorallia: Alcyonacea de la Reserva Ecológica Siboney-Juticí, Santiago de Cuba, Cuba

    Directory of Open Access Journals (Sweden)

    Yunier Olivera Espinosa

    2010-12-01

    Full Text Available Se estudió la comunidad de octocorales del arrecife de macizos y canales de la Reserva Ecológica Siboney- Juticí (sur oriente de Cuba con el objetivo de caracterizar su composición, estructura y estado de conservación, así como inferir a partir de estas las condiciones ambientales imperantes en el área. La investigación se realizó entre enero y junio de 2009, en seis localidades ubicadas entre 12m y 17m de profundidad. Como unidad de muestreo se empleó un marco de 1m², el cual fue puesto en zigzag cada 2m sobre la superficie del arrecife de macizos. Se determinó, por localidad, la densidad de colonias y se infirieron los grados de severidad, constancia ambiental, tensión hidrodinámica y el Índice Comparativo de Contaminación. Se determinaron, además, los daños en la comunidad de octocorales. Se analizaron 752 colonias e identificaron 25 especies de octocorales. Eunicea flexuosa y Gorgonia ventalina fueron las especies más abundantes. La densidad fluctuó entre 3.58±1.84 colonias/m² y 7.58±2.16 colonias/ m² (densidad de baja a moderada tendiendo a baja. En la zona se infirió una tensión hidrodinámica entre baja y alta, con niveles de contaminación bajos y moderados, y un ambiente generalmente favorable y constante. Los daños de tipo mecánico fueron los más frecuentes, siendo G. ventalina la especie con más colonias dañadas. La comunidad de octocorales del hábitat de macizos y canales de la Reserva Ecológica Siboney-Juticí presentó un buen estado de conservación.

  8. A numerical-statistical approach to determining the representative elementary volume (REV of cement paste for measuring diffusivity

    Directory of Open Access Journals (Sweden)

    Zhang, M. Z.

    2010-12-01

    Full Text Available Concrete diffusivity is a function of its microstructure on many scales, ranging from nanometres to millimetres. Multi-scale techniques are therefore needed to model this parameter. Representative elementary volume (REV, in conjunction with the homogenization principle, is one of the most common multi-scale approaches. This study aimed to establish a procedure for establishing the REV required to determine cement paste diffusivity based on a three-step, numerical-statistical approach. First, several series of 3D cement paste microstructures were generated with HYMOSTRUC3D, a cement hydration and microstructure model, for different volumes of cement paste and w/c ratios ranging from 0.30 to 0.60. Second, the finite element method was used to simulate the diffusion of tritiated water through these microstructures. Effective cement paste diffusivity values for different REVs were obtained by applying Fick’s law. Finally, statistical analysis was used to find the fluctuation in effective diffusivity with cement paste volume, from which the REV was then determined. The conclusion drawn was that the REV for measuring diffusivity in cement paste is 100x100x100 μm3.

    La difusividad del hormigón depende de su microestructura a numerosas escalas, desde nanómetros hasta milímetros, por lo que se precisa de técnicas multiescala para representar este parámetro. Junto con el principio de homogeneización, uno de los métodos multiescala más habituales es el volumen elemental representativo (VER. El objeto de este estudio era establecer un procedimiento que permitiera determinar el VER necesario para calcular la difusividad de la pasta de cemento, basándose en un método numéricoestadístico que consta de tres etapas. Primero, se crearon varias series de microestructuras de pasta de cemento en 3D con HYMOSTRUC3D, un programa que permite crear un modelo de la hidratación y microestructura del cemento. Luego se empleó el método de

  9. Arquitetura de terra: uma solução ecológica, econômica e auto sustentável / Earth architecture: an ecological, economic and self-sustainable solution

    OpenAIRE

    Arini, Ruy

    2015-01-01

    Trabalho enviado em 22 de fevereiro de 2015. Aceito em 25 de fevereiro de 2015.DOI: http://dx.doi.org/10.12957/rdc.2015.15196Resumo Uma habitação construída com arquitetura de terra crua é caracterizada por conforto ambiental, boa resistência à compressão, durabilidade e custo econômico devido ao uso de tijolos e blocos ecológicos, que são curados a frio, eliminando a energia utilizada pelas indústrias para a sua produção e comercialização da cerâmica. O design ecológico de alvenaria permit...

  10. Conhecimento ecológico tradicional no fragmento da planície de inundação do alto rio Paraná: percepção ecológica dos pescadores Upper Paraná River floodplain fishermen’s traditional ecological knowledge: fishermen’s ecological feeling

    Directory of Open Access Journals (Sweden)

    Adriana Rosa Carvalho

    2002-05-01

    Full Text Available O conhecimento ecológico é uma sabedoria popular empírica acumulada pela prática de atividades em ambientes naturais. Alterações nos ecossistemas afetam o estoque dos recursos naturais explorados, bem como a prática tradicional deles dependente. Neste trabalho, é apresentado o conhecimento ecológico tradicional dos pescadores da planície de inundação do alto rio Paraná, regiões de Porto Rico (PR e Porto São José, Estado do Paraná. Um breve relato da teoria de fragmentação de habitats é apresentado, visto que esse ambiente está fragmentado pela construção de barragens de hidrelétricas. Três frases e um provérbio que revelam a dinâmica dos processos ecológicos dentre os pescadores foram anotados e confrontados com o conhecimento científico já reunido sobre a região. As frases demonstram uma interpretação popular em consonância com as descobertas científicas na planície. Essa sabedoria está ameaçada pela fragmentação da planície e pela perda da tradição, devido ao abandono da atividade pesqueira.The ecological knowledge is an empiric popular wisdom stored by the fishermen’s natural environmental practice. Changes in ecosystem affect the explored natural resources as well as the traditional practice dependent on them. This paper aims at presenting the upper Paraná river floodplain fishermen’s traditional ecological knowledge from Porto Rico (PR and Porto São José (PR regions. A brief comment on fragmentation theory is presented because of the floodplain fragmentation imposed by the construction of hydroelectric dams. Three phrases and one proverb, which reveal the dynamics of the fishermen’s ecological process, were registered and confronted with the scientific knowledge of the region. The phrases show a popular and traditional interpretation in agreement with the upper Paraná river floodplain scientific discoveries. The ecosystem fragmentation and loss of tradition, due to the fishery practice

  11. Two Phase Flow in Nodular Systems: Laboratory Experiments Écoulements polyphasiques dans des systèmes nodulaires : expériences de laboratoire

    Directory of Open Access Journals (Sweden)

    Alhanai W.

    2006-11-01

    chelle sont de même nature qu'à l'échelle locale. - Dans le cas d'un système nodulaire, la désaturation quasi-statique peut conduire à une inversion du rôle des régions (la région initialement la plus perméable peut devenir la région la moins perméable et inversement. - Il y a une grande différence de comportement entre les deux systèmes nodulaires suivants : système I où la région oméga constitue le nodule et la région êta la région continue, et système II où la région oméga est la région continue et la région êta constitue le nodule.

  12. Modification de la surface du cuivre par implantation ionique par source plasma (IISP): applications à l’érosion cathodique dans les systèmes à arcs

    OpenAIRE

    Roy, F

    2006-01-01

    L’érosion cathodique est un phénomène bien connu qui limite la durée de vie de l’électrode négative dans les systèmes à arcs. Dans le présent mémoire, nous avons tenté de voir si la formation de précipités nanométriques d’oxyde de cuivre pouvait réduire l’érosion cathodique nécessaire au maintien de l’arc en mode thermo-champ (T-F). Les dits précipités ont été produits par implantation ionique par source plasma (IISP). Avec l’aide de techniques de caractérisation telle que la microscopie à fo...

  13. Un système de pilotage de la performance publique à dominante managériale : analyse de l'expérience de Dubaï

    OpenAIRE

    Fninou , Bouchra; Meyssonnier , François

    2013-01-01

    Le mode de gestion de l’administration publique de Dubaï est très spécifique. Après avoir présenté les caractéristiques de la cité-État et les facteurs de contingence s’exerçant sur son administration, le système de pilotage de la performance publique de Dubaï, fondé sur les principes du New Public Management est décrit et analysé. L’article montre la cohérence, les apports et les limites de cette démarche emblématique d’une modernisation de l’administration publique fondée sur la culture du ...

  14. Les nouvelles perspectives d'analyse spatiale des nuisances sonores. Le projet SIGAUR (Système d'Information Géographique et Acoustique URbaine

    Directory of Open Access Journals (Sweden)

    Erwan Quesseveur

    1999-06-01

    Full Text Available Ce rapport présente un projet de recherche sur l’intégration d’une couche d’information de nuisances acoustiques dans un système d’information géographique.Après un développement sur l’état de la pollution et des moyens aujourd’hui en vigueur pour la combattre, on va montrer les nouvelles perspectives offertes pour l’analyse spatiale du bruit. En confrontant cette nuisance aux enjeux du territoire, elle peut devenir un véritable critère de décision en aménagement du territoire.Ce projet résulte d’une collaboration entre le Centre Scientifique et Technique du Bâtiment C.S.T.B. et l’équipe " S.I.G. " de l'Institut de Géographie Alpine (IGA

  15. Mal être et souffrance psychique : un défi pour le système de santé ?

    OpenAIRE

    Grand, Alain

    2018-01-01

    Dans un contexte socio-économique qui se durcit, on peut observer l’apparition d’un “effet ciseau” vis-à-vis de la santé. La dette sociale et le déficit de la sécurité sociale se creusent de manière abyssale (30,6 milliards d’euros de déficit prévu pour l’exercice 2010) ce qui affecte notamment les hôpitaux publics, et tout particulièrement les Centres Hospitaliers Régionaux. Dans ce contexte, l’objectif général de notre système de santé est d’adapter l’offre aux besoins. Or, avec le vieillis...

  16. Daňový systém Francouzské republiky s akcentem na přímé daně

    OpenAIRE

    Chocholáč, Jan; Průša, Petr

    2016-01-01

    Článek se zabývá daňovým systémem Francouzské republiky s důrazem na přímé daně, které se skládají z daně z příjmu a daně z nemovitostí. Tento článek podrobně popisuje daň příjmu fyzických osob, daň z příjmu právnických osob, daň z nemovitosti, daň dědickou a daň darovací. Article deals with the tax system of the French Republic with emphasis on direct taxes which consists of income taxes and property taxes. The article described in detail the tax on personal income tax, corporate income t...

  17. Microbiote intestinal et obésité : impact des lipides bioactifs issus du système endocannabinoïde

    Directory of Open Access Journals (Sweden)

    Cani Patrice D.

    2016-05-01

    Full Text Available De nombreux travaux ont associé le microbiote intestinal au développement de désordres métaboliques. Parmi les mécanismes potentiellement impliqués dans le dialogue bactéries-hôtes, le système endocannabinoïde (eCB et ses lipides bioactifs jouent un rôle important. Nos travaux suggèrent l’existence d’un dialogue à double-sens entre l’organisme et les bactéries : le tissu adipeux contrôlerait la fonction barrière de l’intestin; et les bactéries de l’intestin seraient capables de contrôler le métabolisme du tissu adipeux.

  18. El conocimiento de la Posidonia oceanica y sus funciones ecológicas como herramienta de gestión litoral. La realización de encuestas a los usuarios de playas y calas de la isla de Menorca

    Directory of Open Access Journals (Sweden)

    Francesc Xavier Roig i Munar

    2001-01-01

    Full Text Available La Posidonia oceanica juega un papel primordial como producción de sedimento y defensa de las playas y calas de la isla de Menorca. La realización de encuestas de percepción a los usuarios de playa sobre el conocimiento y las funciones ecológicas de esta planta resulta una herramienta de gestión primordial para la conservación y mantenimiento de los espacios litorales insulares.

  19. Intégration des Tice et apprentissage de l'enseignement : une approche systémique Integrating technology and learning to teach: a systemic perspective

    Directory of Open Access Journals (Sweden)

    Francis Bangou

    2006-11-01

    Full Text Available De nombreuses études soulignent à quel point il est complexe d'analyser les changements pédagogiques entraînés par l'intégration des Tice. Cette recherche-action tente d'analyser de façon systémique les interrelations qu'entretient l'intégration des Tice avec les changements pédagogiques dans le cadre d'un programme de formation d'enseignants en langues étrangères au sein d'une grande université américaine. Le cadre théorique nous permettra tout d'abord de délimiter une perspective systémique et de présenter notre conception de l'intégration des Tice et de l'apprentissage. Puis, nous présenterons notre étude et en résumerons les principaux résultats afin d'illustrer la complexité d'une telle relation.Many studies underline how difficult it is to analyse the pedagogical changes caused by the integration of technology. This action research aims to analyse, from a systemic point of view, the interrelations that exist between the integration of technology and pedagogical change. The study took place in a foreign and second language teacher education program at a large American university. First, we will define a systemic perspective as well as the concepts of technology integration and learning. Then, to illustrate the complexity of such relationship, we will describe our study and summarize the main results.

  20. Gestion de l'énergie d'un système hybride pile à combustible/batterie basée sur la commande optimale

    Directory of Open Access Journals (Sweden)

    M. N. SID

    2015-03-01

    Full Text Available Ce papier traite de l'optimisation de gestion de l'énergie électrique dans un véhicule hybride (pile à combustible/batterie, afin de minimiser autant que possible la consommation de l'hydrogène avec le maintien de l'état de charge de la batterie. Premièrement, on présente les sources d'énergies utilisées dans cette étude, la modélisation du système hybride, le choix de type des convertisseurs d'électronique de puissance utilisés et le dimensionnement de ces éléments.Deuxièmement on traite le problème d'optimisation sous contraintes basée sur le principe du minimum de Pontriaguine en introduisant la fonction Hamiltonienne de la commande optimale.Cette stratégie a été évaluée dans un environnement de simulation sous Matlab/Simulink utilisant quatre cycles de conduite standards.Une étude comparative en terme de consommation d'hydrogène a été faite avec deux autres stratégies la première dite thermostat qui est une stratégie très simple basée sur les contraintes imposées par les sources, la seconde approche consiste à utiliser un filtre passe-bas à la sortie de la puissance demandée afin de respecter les contraintes en dynamique sur la source principale. La stratégie traitée présente une bonne amélioration de la consommation d'hydrogène en adoptant une bonne stratégie de gestion de l'énergie électrique dans le système hybride.