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Sample records for reut andres pik

  1. Reut and Beck columns: effects of end gravity force, translational and rotational inertias

    OpenAIRE

    Luis G. Arboleda Monsalve; David G. Zapata Medina; J. Darío Aristizabal Ochoa

    2012-01-01

    Se presenta la estabilidad de las colunmas de Reut y Beck sometidas a cualquier combinación de fuerzas compresivas axiales de gravedad y no conservativas (fuerza fija a lo largo de una línea o seguidora) utilizando la formulación dinámica. El método propuesto es general y captura el pandeo estático (o divergencia) y la inestabilidad dinámica ("flameo") de columnas en voladizo. Los efectos de la fuerza de gravedad y las inercias traslacionales y rotacionales a lo largo del elemento se analizan...

  2. Peapiiskop Andres Põderi jutlus / Andres Põder

    Index Scriptorium Estoniae

    Põder, Andres, 1949-

    2005-01-01

    Peapiiskop Andres Põderi jutlus oma ametissepühitsemise jumalateenistusel 2. veebruaril. Ilmunud ka: Põder, Andres. Pärimuste pöördepunkt : kõned ja kirjutised. - Tallinn : Kunst, 2007, 107-112

  3. Andres Ehin Jaapanist Iirini

    Index Scriptorium Estoniae

    2006-01-01

    Andres Ehin valiti Ülemaailmse Haiku Assotsiatsiooni auliikmeks ja kirjaniku inglisekeelset luulekogu "Moose Beetle Swallow" esitleti 2005. aasta Euroopa kultuuripealinnas Corkis Iirimaal. Järgneb: Looming 2006, nr. 2, lk. 311

  4. Somatic PIK3CA mutations in seven patients with PIK3CA-related overgrowth spectrum.

    Science.gov (United States)

    Yeung, Kit San; Ip, Janice Jing Kun; Chow, Chin Pang; Kuong, Evelyn Yue Ling; Tam, Paul Kwong-Hang; Chan, Godfrey Chi-Fung; Chung, Brian Hon-Yin

    2017-04-01

    Somatic mutations in PIK3CA cause many overgrowth syndromes that have been recently coined the "PIK3CA-Related Overgrowth Spectrum." Here, we present seven molecularly confirmed patients with PIK3CA-Related Overgrowth Spectrum, including patients with Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, Scoliosis/Skeletal and Spinal syndrome, Klippel-Trenaunay syndrome, lymphatic malformation and two with atypical phenotypes that cannot be classified into existing disease categories. The literature on PIK3CA-Related Overgrowth Spectrum, suggests that PIK3CA c.1258T>C; p.(Cys420Arg), c.1624G>A; p.(Glu542Lys), c.1633G>A; p.(Glu545Lys), c.3140A>G; p.(His1047Arg), and c.3140A>T; p.(His1047Leu) can be identified in approximately 90% of patients without brain overgrowth. Therefore, droplet digital polymerase chain reaction targeting these mutation hotspots could be used as the first-tier genetic test on patients with PIK3CA-Related Overgrowth Spectrum who do not have signs of overgrowth in their central nervous system. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  5. Graafikatriennaali peapreemia Andres Talile

    Index Scriptorium Estoniae

    2001-01-01

    Tallinna XII graafikatriennaali preemiad: grand prix - Andres Tali; 3 võrdset preemiat - Janne Laine, Leonards Laganovskis, Peeter Laurits; diplomid - Lynne Allen, Lucrecia Urbano, Vladimir Tshaika, Zora Stanè, Endi Poskovic, Päivikki Kallio; EKM preemia - Tif Bitmap; Tallinna linna preemia - Ülle Marks ja Jüri Kass; eripreemiad: - J. Laine (Eesti Pank), Vive Tolli (Paletti Eesti AS), Martins Ratniksh, Juris Boiko, T. Bitmap (Balteco AS). Žürii koosseis

  6. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

    Science.gov (United States)

    Ilic, Nina; Birsoy, Kıvanç; Aguirre, Andrew J.; Kory, Nora; Pacold, Michael E.; Singh, Shambhavi; Moody, Susan E.; DeAngelo, Joseph D.; Spardy, Nicole A.; Freinkman, Elizaveta; Weir, Barbara A.; Cowley, Glenn S.; Root, David E.; Asara, John M.; Vazquez, Francisca; Widlund, Hans R.; Sabatini, David M.; Hahn, William C.

    2017-01-01

    Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand how mutant PIK3CA contributes to cancer cell proliferation, we used genome scale loss-of-function screening in a large number of genomically annotated cancer cell lines. As expected, we found that PIK3CA mutant cancer cells require PIK3CA but also require the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH). To understand the relationship between oncogenic PIK3CA and OGDH function, we interrogated metabolic requirements and found an increased reliance on glucose metabolism to sustain PIK3CA mutant cell proliferation. Functional metabolic studies revealed that OGDH suppression increased levels of the metabolite 2-oxoglutarate (2OG). We found that this increase in 2OG levels, either by OGDH suppression or exogenous 2OG treatment, resulted in aspartate depletion that was specifically manifested as auxotrophy within PIK3CA mutant cells. Reduced levels of aspartate deregulated the malate–aspartate shuttle, which is important for cytoplasmic NAD+ regeneration that sustains rapid glucose breakdown through glycolysis. Consequently, because PIK3CA mutant cells exhibit a profound reliance on glucose metabolism, malate–aspartate shuttle deregulation leads to a specific proliferative block due to the inability to maintain NAD+/NADH homeostasis. Together these observations define a precise metabolic vulnerability imposed by a recurrently mutated oncogene. PMID:28396387

  7. SANA - project results and PIK contributions

    Energy Technology Data Exchange (ETDEWEB)

    Bellmann, K.; Erhard, M.; Flechsig, M.; Grote, R.; Suckow, F.

    1998-03-01

    This report includes the final project results of the two groups at PIK, involved in the project: Firstly, the newly developed physiologically-based forest growth model FORSANA was applied for the first time to three pine stands, which differed largely in their air pollution and deposition history. (The evaluation of the model is presented in PIK Report 32). The model was able to explain the growth during the last decades of at least two of the three stands from the climatic and deposition conditions at the sites. The third site was shown to be exceptional with respect to its relation between dimension and age, and was supposed to be exposed to major disturbances in the past, which could not be accounted for by the model. To extrapolate from the stand level to the regional level, FORSANA was initialised with spatially explicit data from forestry inventory and soil maps. Simulations were executed with measured weather records and regional distributions of deposition and air pollution, which were estimated on the basis of emission inventories and wind directions. Different assumptions about the development of air pollution had been applied to investigate different pollution abatement strategies. The results showed that a positive effect can be expected from the actual emission reductions close the main centres of emission, but showed also that this effect is decreasing with increasing distance from the emission source. (orig./KW)

  8. Mutations of PIK3CA in gastric adenocarcinoma

    Directory of Open Access Journals (Sweden)

    So Samuel

    2005-03-01

    Full Text Available Abstract Background Activation of the phosphatidylinositol 3-kinase (PI3K through mutational inactivation of PTEN tumour suppressor gene is common in diverse cancer types, but rarely reported in gastric cancer. Recently, mutations in PIK3CA, which encodes the p110α catalytic subunit of PI3K, have been identified in various human cancers, including 3 of 12 gastric cancers. Eighty percent of these reported mutations clustered within 2 regions involving the helical and kinase domains. In vitro study on one of the "hot-spot" mutants has demonstrated it as an activating mutation. Methods Based on these data, we initiated PIK3CA mutation screening in 94 human gastric cancers by direct sequencing of the gene regions in which 80% of all the known PIK3CA mutations were found. We also examined PIK3CA expression level by extracting data from the previous large-scale gene expression profiling study. Using Significance Analysis of Microarrays (SAM, we further searched for genes that show correlating expression with PIK3CA. Results We have identified PIK3CA mutations in 4 cases (4.3%, all involving the previously reported hotspots. Among these 4 cases, 3 tumours demonstrated microsatellite instability and 2 tumours harboured concurrent KRAS mutation. Data extracted from microarray studies showed an increased expression of PIK3CA in gastric cancers when compared with the non-neoplastic gastric mucosae (p PIK3CA. Conclusion Our data suggested that activation of the PI3K signalling pathway in gastric cancer may be achieved through up-regulation or mutation of PIK3CA, in which the latter may be a consequence of mismatch repair deficiency.

  9. Andres Rõhu: kujundaja metsast / Andres Rõhu ; intervjueerinud Kaarel Kressa

    Index Scriptorium Estoniae

    Rõhu, Andres, 1965-

    2010-01-01

    Maalikunstnik Andres Rõhu sellest, kuidas temast sai raamatute kujundaja, parematest enda kujundatud raamatutest, südamelähedasematest eesti raamatukujundajatest, maal elamise eelistest. Loetletud A, Rõhu kujundatud teoseid

  10. Maailmaparandajad / Ole Ry, Susanne Andres

    Index Scriptorium Estoniae

    Ry, Ole

    2012-01-01

    Terapeudid Ole Ry ja Susanne Andres räägivad Dr David Berceli loodud TRE (Tension & Trauma Releasing Exercises) harjutuste kasutamise kogemusest erinevate psüühiliste traumade ja pingetega klientide tervise parandamisel

  11. Analysis of PIK3CA mutations in breast cancer subtypes.

    Science.gov (United States)

    Arsenic, Ruza; Lehmann, Annika; Budczies, Jan; Koch, Ines; Prinzler, Judith; Kleine-Tebbe, Anke; Schewe, Christiane; Loibl, Sibylle; Dietel, Manfred; Denkert, Carsten

    2014-01-01

    Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) is a central element of a signaling pathway involved in cell proliferation, survival, and growth. Certain mutations in this pathway result in enhanced PI3K signaling, which is associated with oncogenic cellular transformation and cancer. The aims of this study were to characterize different types of PIK3CA mutations in exons 9 and 20 in a series of primary breast carcinomas and to correlate the results with clinicopathologic parameters and survival. We used frozen tissue samples and sequenced exons 9 and 20 for a series of 241 patients with a diagnosis of breast carcinoma. We found that 15.8% of the primary breast carcinomas possessed PIK3CA mutations in either exon 9 or exon 20. The rate of PIK3CA mutations was increased in HR(+)/HER2(-) tumors (18.6%), but this difference did not reach a statistical significance. The lowest rate of mutations was observed in HR(+)/HER2(+) tumors (5.3%). No statistically significant association was found between the presence of PIK3CA mutations and the prognostic/clinical features of breast cancer, including histologic subtype, Her2 status, axillary lymph node involvement, tumor grade, and tumor stage. However, the presence of the H1047R mutation in 10 samples was associated with a statistically significantly worse overall survival. PIK3CA mutation was found to be a frequent genetic change in all breast cancer subtypes but occurred with the highest rate in HR(+)/HER2(-) tumors. Further studies are needed to validate the prognostic impact of different PIK3CA mutations.

  12. Vulkaner andre steder i Solsystemet

    DEFF Research Database (Denmark)

    Haack, Henning

    2007-01-01

    Der er vulkaner mange andre steder end på Jorden. De indre fire jordlignende planeter har, ligesom mange af solsystemets måner og asteroider, vulkaner, der dog for de flestes vedkommende er udslukte for mange hundrede millioner år siden. Der er direkte observeret vulkanudbrud på Jorden og på...

  13. Geim, Prof. Sir Andre Konstantin

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

  14. PIK-20 and LRV Vehicles Parked on Ramp

    Science.gov (United States)

    1981-01-01

    This photo shows NASA's PIK-20 motor-glider sailplane on the ramp at the Dryden Flight Research Center, Edwards, California. Next to the PIK-20 is the Low Reynolds Number Vehicle (LRV) remotely-piloted research vehicle. The PIK-20E was a sailplane flown at NASA's Ames-Dryden Flight Research Facility (now Dryden Flight Research Center, Edwards, California) beginning in 1981. The vehicle, bearing NASA tail number 803, was used as a research vehicle on projects calling for high lift-over-drag and low-speed performance. Later NASA used the PIK-20E to study the flow of fluids over the aircraft's surface at various speeds and angles of attack as part of a study of airflow efficiency over lifting surfaces. The single-seat aircraft was used to begin developing procedures for collecting sailplane glide performance data in a program carried out by Ames-Dryden. It was also used to study high-lift aerodynamics and laminar flow on high-lift airfoils. Built by Eiri-Avion in Finland, the PIK-20E is a sailplane with a two-cylinder 43-horsepower, retractable engine. It is made of carbon fiber with sandwich construction. In this unique configuration, it takes off and climbs to altitude on its own. After reaching the desired altitude, the engine is shut down and folded back into the fuselage and the aircraft is then operated as a conventional sailplane. Construction of the PIK-20E series was rather unusual. The factory used high-temperature epoxies cured in an autoclave, making the structure resistant to deformation with age. Unlike today's normal practice of laying glass over gelcoat in a mold, the PIK-20E was built without gelcoat. The finish is the result of smooth glass lay-up, a small amount of filler, and an acrylic enamel paint. The sailplane was 21.4 feet long and had a wingspan of 49.2 feet. It featured a wooden, fixed-pitch propeller, a roomy cockpit, wingtip wheels, and a steerable tailwheel.

  15. Expression of PIK3CA, PTEN mRNA and PIK3CA mutations in primary breast cancer

    DEFF Research Database (Denmark)

    Palimaru, Irina; Brügmann, Anja; Wium-Andersen, Marie Kim

    2013-01-01

    PURPOSE: High activity of the intracellular phosphatidylinositol-3 kinase (PI3K) pathway is common in breast cancer. Here, we explore differences in expression of important PI3K pathway regulators: the activator, phosphatidylinositol-3-kinase catalytic subunit alpha (PIK3CA), and the tumour...

  16. Suursaadik Andres Talvik : Prantsusmaa ei ole euroliidu laienemise pooldaja / Andres Talvik ; interv. Marianne Mikko

    Index Scriptorium Estoniae

    Talvik, Andres, 1947-

    2002-01-01

    Eesti suursaadik Prantsusmaal Andres Talvik Prantsusmaa presidendivalimistest, paremäärmuslase Jean-Marie Le Peni pääsemisest selle II vooru, prantslaste vastuseisust EL-i laienemisele, Prantsuse-Saksa suhetest. Andres Talviku elulooandmeid

  17. Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma

    Directory of Open Access Journals (Sweden)

    Bardeesy Nabeel

    2011-02-01

    Full Text Available Abstract Background The genetics of advanced biliary tract cancers (BTC, which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined. Methods To better characterize mutations in established known oncogenes and tumor suppressor genes we tested a mass spectrometric based platform to interrogate common cancer associated mutations across a panel of 77 formalin fixed paraffin embedded archived BTC cases. Results Mutations among three genes, KRAS, NRAS and PIK3CA were confirmed in this cohort. Activating mutations in PIK3CA were identified exclusively in GBC (4/32, 12.5%. KRAS mutations were identified in 3 (13% intra-hepatic cholangiocarcinomas and 1 (33% perihillar cholangiocarcinoma but were not identified in gallbladder carcinomas and extra-hepatic cholangiocarcinoma. Conclusions The presence of activating mutations in PIK3CA specifically in GBC has clinical implications in both the diagnosis of this cancer type, as well as the potential utility of targeted therapies such as PI3 kinase inhibitors.

  18. Somatic mutations of PIK3R1 promote gliomagenesis.

    Directory of Open Access Journals (Sweden)

    Steven N Quayle

    Full Text Available The phosphoinositide 3-kinase (PI3K pathway is targeted for frequent alteration in glioblastoma (GBM and is one of the core GBM pathways defined by The Cancer Genome Atlas. Somatic mutations of PIK3R1 are observed in multiple tumor types, but the tumorigenic activity of these mutations has not been demonstrated in GBM. We show here that somatic mutations in the iSH2 domain of PIK3R1 act as oncogenic driver events. Specifically, introduction of a subset of the mutations identified in human GBM, in the nSH2 and iSH2 domains, increases signaling through the PI3K pathway and promotes tumorigenesis of primary normal human astrocytes in an orthotopic xenograft model. Furthermore, we show that cells that are dependent on mutant P85α-mediated PI3K signaling exhibit increased sensitivity to a small molecule inhibitor of AKT. Together, these results suggest that GBM patients whose tumors carry mutant PIK3R1 alleles may benefit from treatment with inhibitors of AKT.

  19. PIK3CA mutations may be discordant between primary and corresponding metastatic disease in Breast Cancer

    DEFF Research Database (Denmark)

    Dupont Jensen, Jeanette; Laenkholm, Anne-Vibeke; Knoop, Ann

    2011-01-01

    PURPOSE: PIK3CA mutations are frequent in breast cancer and activate the PI3K/Akt pathway. Unexpectedly, PIK3CA mutation appears in general to be associated with better outcome. In a cohort of patients where both primary and metastatic lesions were available the objective was to assess changes...... recurrence than wild type cases (p=0.03). CONCLUSIONS: PIK3CA mutations occur at high frequency in primary and metastatic breast cancer; these may not necessarily confer increased aggressiveness as mutants had a longer time to recurrence. Because PIK3CA status quite frequently changes between primary...... metastatic breast tumors. Samples were analysed for PIK3CA mutations (exon 9 and 20) as well as immunohistochemical evaluation for PTEN, pAKT, Ki67, ER and HER2. RESULTS: PIK3CA mutation was detected in 45 % of the primary tumors. Overall there was a net gain in mutation in metastatic disease, to 53...

  20. PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations

    Directory of Open Access Journals (Sweden)

    Katsuhiko Nosho

    2008-06-01

    Full Text Available Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN. Microsatellite instability (MSI and CpG island methylator phenotype (CIMP are important molecular classifiers in colorectal cancer. However, the relationship between PIK3CA mutation, MSI and CIMP remains uncertain. Using Pyrosequencing technology, we detected PIK3CA mutations in 91 (15% of 590 population-based colorectal cancers. To determine CIMP status, we quantified DNA methylation in eight CIMP-specific promoters [CACNA1G, CDKN2A (p16, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1] by real-time polymerase chain reaction (MethyLight. PIK3CA mutation was significantly associated with mucinous tumors [P = .0002; odds ratio (OR = 2.44], KRAS mutation (P < .0001; OR = 2.68, CIMP-high (P = .03; OR = 2.08, phospho–ribosomal protein S6 expression (P = .002; OR = 2.19, and FASN expression (P = .02; OR = 1.85 and inversely with p53 expression (P = .01; OR = 0.54 and β-catenin (CTNNB1 alteration (P = .004; OR = 0.43. In addition, PIK3CA G-to-A mutations were associated with MGMT loss (P = .001; OR = 3.24 but not with MGMT promoter methylation. In conclusion, PIK3CA mutation is significantly associated with other key molecular events in colorectal cancer, and MGMT loss likely contributes to the development of PIK3CA G>A mutation. In addition, Pyrosequencing is useful in detecting PIK3CA mutation in archival paraffin tumor tissue. PIK3CA mutational data further emphasize heterogeneity of colorectal cancer at the molecular level.

  1. Cafe Lyon = Cafe Lyon / Andres Labi

    Index Scriptorium Estoniae

    Labi, Andres, 1977-

    2013-01-01

    Cafe Lyon (Meistri 22, Tallinn) sisekujundusest. Autorid: Janno Roos, Andres Labi, Kristel Jakobson (Ruumilabor). Prantsuse Lütseumi direktori Lauri Leesi arvamus. Disainibüroo Ruumilabor lühitutvustus

  2. Andres Noormets - olemuselt luuletaja, vormilt lavastaja / Andres Noormets ; intervjueerinud Tiiu Laks

    Index Scriptorium Estoniae

    Noormets, Andres, 1963-

    2010-01-01

    Andres Noormets endast, oma lavastustest, näitlemisest ja lavastamisest, elu mõttest, uue otsimisest oma teatritöödega, sellest, mis endiselt paelub teatris ja praegusi teatritegemisi enim mõjutab, ise kirjutamisest jm. Andres Noormetsa eluloolisi andmeid

  3. Gain of Function Mutations of PIK3CD as a Cause of Primary Sclerosing Cholangitis.

    Science.gov (United States)

    Hartman, Heather N; Niemela, Julie; Hintermeyer, Mary K; Garofalo, Mary; Stoddard, Jennifer; Verbsky, James W; Rosenzweig, Sergio D; Routes, John M

    2015-01-01

    Gain of function (GOF) mutation in the p110δ catalytic subunit of the phosphatidylinositol-3-OH kinase (PIK3CD) is the cause of a primary immunodeficiency (PID) characterized by recurrent sinopulmonary infections and lymphoproliferation. We describe a family of two adults and three children with GOF mutation in PIK3CD, all with recurrent sinopulmonary infections and varied infectious and non-infectious complications. The two adults have Primary Sclerosing Cholangitis (PSC) without evidence of Cryptosporidium parvum infection and have required liver transplantation. PSC is a novel phenotype of GOF mutation in PIK3CD.

  4. Oncogenic PIK3CA Mutation and Dysregulation in Human Salivary Duct Carcinoma

    Directory of Open Access Journals (Sweden)

    Wanglong Qiu

    2014-01-01

    Full Text Available Salivary duct carcinoma (SDC is an aggressive malignant tumor with a high mortality, which resembles high-grade breast ductal carcinoma in morphology. The parotid gland is the most common location. Its molecular genetic characteristics remain largely unknown. We have previously reported high incidence of PIK3CA somatic mutations in head and neck squamous cell carcinoma, particularly in pharyngeal cancers. Here we examined the PIK3CA gene expression status and hotspot mutations in six cases of SDC by immunohistochemistry and genomic DNA sequencing. Immunohistochemistry showed that PIK3CA expression was elevated in all six patients with SDC. By DNA sequencing, two hotspot mutations of the PIK3CA gene, E545K (exon 9 and H1047R (exon 20, were identified in two of the six cases. Our results support that oncogenic PIK3CA is upregulated and frequently mutated in human SDC, adding evidence that PIK3CA oncogenic pathway is critical in the tumorigenesis of SDC, and may be a plausible drug target for this rare disease.

  5. Mutation distributions and clinical correlations of PIK3CA gene mutations in breast cancer.

    Science.gov (United States)

    Dirican, Ebubekir; Akkiprik, Mustafa; Özer, Ayşe

    2016-06-01

    Breast cancer (BCa) is the most common cancer and the second cause of death among women. Phosphoinositide 3-kinase (PI3K) signaling pathway has a crucial role in the cellular processes such as cell survival, growth, division, and motility. Moreover, oncogenic mutations in the PI3K pathway generally involve the activation phosphatidylinositol-4,5-bisphosphate 3-kinase-catalytic subunit alpha (PIK3CA) mutation which has been identified in numerous BCa subtypes. In this review, correlations between PIK3CA mutations and their clinicopathological parameters on BCa will be described. It is reported that PIK3CA mutations which have been localized mostly on exon 9 and 20 hot spots are detected 25-40 % in BCa. This relatively high frequency can offer an advantage for choosing the best treatment options for BCa. PIK3CA mutations may be used as biomarkers and have been major focus of drug development in cancer with the first clinical trials of PI3K pathway inhibitors currently in progress. Screening of PIK3CA gene mutations might be useful genetic tests for targeted therapeutics or diagnosis. Increasing data about PIK3CA mutations and its clinical correlations with BCa will help to introduce new clinical applications in the near future.

  6. Tree-level ({pi},K) amplitude and analyticity

    Energy Technology Data Exchange (ETDEWEB)

    Vereshagin, V.V. [Theoretical Physics Department, Institute of Physics, St. Petersburg State University, 198904 St. Petersburg (Russia)

    1997-05-01

    I consider the tree-level amplitude describing all three channels of the binary ({pi},K) reaction, as a meromorphic, polynomially bounded function of three dependent complex variables. Using the Mittag-Leffler theorem, I construct three convergent partial fraction expansions, each one being applied in the corresponding domain. Noting that the mutual intersections of those domains are nonempty, I employ analytical continuation. It is shown that the necessary conditions to make such a continuation feasible are the following: (1) The only parameters completely determining the amplitude are the on-shell couplings and masses; (2) these parameters are restricted by a certain (infinite) system of bootstrap equations; (3) the full cross-symmetric amplitude takes the dual form even when the Pomeron contribution is taken into account; (4) this latter contribution corresponds to a nonresonant background which, in turn, is expressed in terms of cross-channel resonance parameters. Also, it is demonstrated that chiral symmetry provides a unique scale for the mentioned parameters, the resonance saturation effect appearing as a direct consequence of the above results. {copyright} {ital 1997} {ital The American Physical Society}

  7. Program for studying fundamental interactions at the PIK reactor facilities

    Science.gov (United States)

    Serebrov, A. P.; Vassiljev, A. V.; Varlamov, V. E.; Geltenbort, P.; Gridnev, K. A.; Dmitriev, S. P.; Dovator, N. A.; Egorov, A. I.; Ezhov, V. F.; Zherebtsov, O. M.; Zinoviev, V. G.; Ivochkin, V. G.; Ivanov, S. N.; Ivanov, S. A.; Kolomensky, E. A.; Konoplev, K. A.; Krasnoschekova, I. A.; Lasakov, M. S.; Lyamkin, V. A.; Martemyanov, V. P.; Murashkin, A. N.; Neustroev, P. V.; Onegin, M. S.; Petelin, A. L.; Pirozhkov, A. N.; Polyushkin, A. O.; Prudnikov, D. V.; Ryabov, V. L.; Samoylov, R. M.; Sbitnev, S. V.; Fomin, A. K.; Fomichev, A. V.; Zimmer, O.; Cherniy, A. V.; Shoka, I. V.

    2016-05-01

    A research program aimed at studying fundamental interactions by means of ultracold and polarized cold neutrons at the GEK-4-4' channel of the PIK reactor is presented. The apparatus to be used includes a source of cold neutrons in the heavy-water reflector of the reactor, a source of ultracold neutrons based on superfluid helium and installed in a cold-neutron beam extracted from the GEK-4 channel, and a number of experimental facilities in neutron beams. An experiment devoted to searches for the neutron electric dipole moment and an experiment aimed at a measurement the neutron lifetime with the aid of a large gravitational trap are planned to be performed in a beam of ultracold neutrons. An experiment devoted to measuring neutron-decay asymmetries with the aid of a superconducting solenoid is planned in a beam of cold polarized neutrons from the GEK-4' channel. The second ultracold-neutron source and an experiment aimed at measuring the neutron lifetime with the aid of a magnetic trap are planned in the neutron-guide system of the GEK-3 channel. In the realms of neutrino physics, an experiment intended for sterile-neutrino searches is designed. The state of affairs around the preparation of the experimental equipment for this program is discussed.

  8. André Petermann (1922-2011)

    CERN Multimedia

    2012-01-01

    The CERN theory community mourns the loss of André Petermann, one of the first members of the Theory Division, who passed away last August in his 89th year. He pioneered, together with his advisor Stueckelberg, the renormalization group, one of the fundamental ideas in quantum field theory that underlies the modern theory of phase transitions as well as asymptotic freedom and the quest for unification of all the particle interactions.   André was among the very first staff members of CERN, which at the beginning was a small group of theorists at the Niels Bohr Institute in Copenhagen, headed by Bohr himself.  When the group moved to Geneva, they first occupied a set of barracks in Cointrin, next to the airport, before moving to the University of Geneva, and then finally settling on the Meyrin site. André was our last direct contact with our nomadic origins. The importance of André’s early work on the renormalization group was recogn...

  9. Andre on alati tantsida tahtnud / Anu Mõttus

    Index Scriptorium Estoniae

    Mõttus, Anu

    2009-01-01

    Koolitantsu maakonnavoorud on peetud. Igast maakonnast pääsevad piirkonnavooru kuni pooled tantsud. Umbes sama edasipääsuprotsent on ka Andre Laine tantsudel, kelle koolitantsu vaimustus algas Kanepi Gümnaasiumi õpilasena ja kes praeguseks on selle gümnaasiumi tantsupedagoog

  10. Eesti fond rahastab Vene infotehnoloogiat / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2006-01-01

    Martinson Trigon Venture Partners (MTVP) loob uue tarkvarainvesteeringute fondi, mis viib endise NSVL-i alale kuni 780 miljonit krooni, fond võtab sihiks kümmekond uut ettevõtet. MTVP esimese fondi investeeringutest. Fondide juhi Andres Susi selgitusi. Lisa: Martinson Trigon Venture Partners osalusega firmad; Vt. samas: Moskvas pole raha ja geeniused kohtunud

  11. André Rousset 1930-2001

    CERN Multimedia

    2001-01-01

    André Rousset in 1962 , seen working on BP3, one of the earlier bubble chambers, with André Lagarrigue (standing). André Rousset died on 1 July at the age of 70. For those who lived through the Gargamelle epic, his name is linked with the success of the great bubble chamber that made possible the 1973 discovery of neutral currents. A graduate of Paris's famous Ecole Polytechnique which produced so many great names in particle physics, André Rousset, a native of southern France, joined Louis Leprince-Ringuet's famous laboratory at the Polytechnique in 1954. Among other topics, Rousset played a part in the cosmic ray experiments at the Pic du Midi in the Pyrénées and designed heavy liquid bubble chambers. A Professor at the Ecole des Mines from 1960 onwards, he became deputy director of Louis Leprince-Ringuet's laboratory in 1964. In 1969 he came to CERN where, logically, he headed the TCL group in charge of heavy liquid bubble chambers. In thi...

  12. Andres Kollist teadusraamatukogude nõukogu esimeheks

    Index Scriptorium Estoniae

    2009-01-01

    8. sept. 2009 valis teadusraamatukogude nõukogu oma uueks esimeheks Tallinna Ülikooli Akadeemilise Raamatukogu direktori Andres Kollisti, senine nõukogu esimees Martin Hallik astus kohalt tagasi ning pühendus ELNET Konsortsiumi juhatuse esimehena raamatukogude avalike huvide eest seismisele

  13. PIK3CD promoted proliferation in diffuse large B cell lymphoma through upregulation of c-myc.

    Science.gov (United States)

    Cui, Wenli; Zheng, Shutao; Li, Xinxia; Ma, Yuqing; Sang, Wei; Liu, Ming; Zhang, Wei; Zhou, Xiaoyan

    2016-09-01

    Despite PIK3CD has been extensively reported in cancers, however, little evidence has been available regarding its role in the setting of diffuse large B cell lymphoma (DLBCL). In the present study, to investigate the role of PIK3CD in DLBCL, relevant experiments were carried out on both in vivo clinical tissue level and in vitro cell line level. Prognostic and clinicopathological significance were analyzed after immunohistochemical assay of PIK3CD expression on DLBCL tissue microarray. MTT assay and flow cytometry were employed to evaluate the proliferative variation, cell cycle, and apoptosis. Athymic nude mice xenografted with DLBCL cell line were employed to confirm the role of PIK3CD. It was found that there was a significant difference between expression of PIK3CD and international prognosis index (IPI), performance state (PS), and inferior overall prognosis. Furthermore, PIK3CD can promote proliferation and prevent apoptosis in DLBCL cells in vitro through upregulation of c-myc and p-AKT and in contrast downregulation of p21 and p27. In nude mice model, knock-down of PIK3CD was shown to be able to suppress the proliferation of DLBCL but not significantly compared with control group. Taken together, our study showed that PIK3CD can promote proliferation of DLBCL cells both in vitro and in vivo, suggesting that PIK3CD could be druggable in the therapy of DLBCL.

  14. Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer.

    Directory of Open Access Journals (Sweden)

    Paolo Cossu-Rocca

    Full Text Available Triple Negative Breast Cancer (TNBC accounts for 12-24% of all breast carcinomas, and shows worse prognosis compared to other breast cancer subtypes. Molecular studies demonstrated that TNBCs are a heterogeneous group of tumors with different clinical and pathologic features, prognosis, genetic-molecular alterations and treatment responsivity. The PI3K/AKT is a major pathway involved in the regulation of cell survival and proliferation, and is the most frequently altered pathway in breast cancer, apparently with different biologic impact on specific cancer subtypes. The most common genetic abnormality is represented by PIK3CA gene activating mutations, with an overall frequency of 20-40%. The aims of our study were to investigate PIK3CA gene mutations on a large series of TNBC, to perform a wider analysis on genetic alterations involving PI3K/AKT and BRAF/RAS/MAPK pathways and to correlate the results with clinical-pathologic data.PIK3CA mutation analysis was performed by using cobas® PIK3CA Mutation Test. EGFR, AKT1, BRAF, and KRAS genes were analyzed by sequencing. Immunohistochemistry was carried out to identify PTEN loss and to investigate for PI3K/AKT pathways components.PIK3CA mutations were detected in 23.7% of TNBC, whereas no mutations were identified in EGFR, AKT1, BRAF, and KRAS genes. Moreover, we observed PTEN loss in 11.3% of tumors. Deregulation of PI3K/AKT pathways was revealed by consistent activation of pAKT and p-p44/42 MAPK in all PIK3CA mutated TNBC.Our data shows that PIK3CA mutations and PI3K/AKT pathway activation are common events in TNBC. A deeper investigation on specific TNBC genomic abnormalities might be helpful in order to select patients who would benefit from current targeted therapy strategies.

  15. Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

    Energy Technology Data Exchange (ETDEWEB)

    Murat, C.B.; Braga, P.B.S.; Fortes, M.A.H.Z. [Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Bronstein, M.D. [Unidade de Neuroendocrinologia, Serviço de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Corrêa-Giannella, M.L.C.; Giorgi, R.R. [Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

    2012-07-13

    The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting macroadenomas, and 15 nonfunctioning macroadenomas. Direct sequencing of exons 9 and 20 assessed by qPCR was employed to investigate the presence of mutations and genomic amplification defined as a copy number ≥4. Previously identified PIK3CA mutations (exon 20) were detected in four cases (12.1%). Interestingly, the Chinese study reported mutations only in invasive tumors, while we found a PIK3CA mutation in one noninvasive corticotroph microadenoma. PIK3CA amplification was observed in 21.2% (7/33) of the cases. This study demonstrates the presence of somatic mutations and amplifications of the PIK3CA gene in a second series of pituitary adenomas, corroborating the previously described involvement of the PI3K/Akt signaling pathway in the tumorigenic process of this gland.

  16. de Thymus fontanesii Boiss & Reut

    African Journals Online (AJOL)

    AKA BOKO

    Thymus fontanesii (thyme) is an aromatic plant, common in Algeria and widely used by local people for its medicinal properties. The essential oil from this plant originating in the west of Algeria, is the subject in this article of a study physicochemical and microbiological. The extraction of the oil was carried out by water steam ...

  17. de Thymus fontanesii Boiss & Reut

    African Journals Online (AJOL)

    AKA BOKO

    obtained for the essential oils of Thymus vulgaris and Thymus Longiflorus, with the exception of optical rotation and miscibility in ethanol. The activity of the essential oil of Thymus fontanesii on bacterial strains (Escherichia coli ATCC 25922, Enterobacter cloaceae, Pseudomonas aeruginosa, Pseudomonas fluorescens ...

  18. The Capsicum annuum class IV chitinase ChitIV interacts with receptor-like cytoplasmic protein kinase PIK1 to accelerate PIK1-triggered cell death and defence responses.

    Science.gov (United States)

    Kim, Dae Sung; Kim, Nak Hyun; Hwang, Byung Kook

    2015-04-01

    The pepper receptor-like cytoplasmic protein kinase, CaPIK1, which mediates signalling of plant cell death and defence responses was previously identified. Here, the identification of a class IV chitinase, CaChitIV, from pepper plants (Capsicum annuum), which interacts with CaPIK1 and promotes CaPIK1-triggered cell death and defence responses, is reported. CaChitIV contains a signal peptide, chitin-binding domain, and glycol hydrolase domain. CaChitIV expression was up-regulated by Xanthomonas campestris pv. vesicatoria (Xcv) infection. Notably, avirulent Xcv infection rapidly induced CaChitIV expression in pepper leaves. Bimolecular fluorescence complementation and co-immunoprecipitation revealed that CaPIK1 interacts with CaChitIV in planta, and that the CaPIK1-CaChitIV complex is localized mainly in the cytoplasm and plasma membrane. CaChitIV is also localized in the endoplasmic reticulum. Transient co-expression of CaChitIV with CaPIK1 enhanced CaPIK1-triggered cell death response and reactive oxygen species (ROS) and nitric oxide (NO) bursts. Co-silencing of both CaChitIV and CaPIK1 in pepper plants conferred enhanced susceptibility to Xcv infection, which was accompanied by a reduced induction of cell death response, ROS and NO bursts, and defence response genes. Ectopic expression of CaPIK1 in Arabidopsis enhanced basal resistance to Hyaloperonospora arabidopsidis infection. Together, the results suggest that CaChitIV positively regulates CaPIK1-triggered cell death and defence responses through its interaction with CaPIK1. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  19. Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer

    National Research Council Canada - National Science Library

    Arsenic, Ruza; Treue, Denise; Lehmann, Annika; Hummel, Michael; Dietel, Manfred; Denkert, Carsten; Budczies, Jan

    2015-01-01

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PIK3CA, is one of the most frequently mutated genes in breast cancer, and the mutation status of PIK3CA has clinical relevance...

  20. Mutación del gen PIK3CA en el carcinoma epidermoide oral

    OpenAIRE

    Pombo Castro, María

    2017-01-01

    PIK3CA es uno de los genes más frecuentemente alterados en el carcinoma epidermoide oral (CEO), por lo que podría considerarse una posible diana terapéutica. Nuestro objetivo es averiguar la frecuencia de mutación y amplificación de PIK3CA en el CEO en nuestra población, y si existe alguna relación entre este hecho y las variables clínicas o la supervivencia. Se incluyeron 98 pacientes (31 lesiones precancerosas y 67 carcinomas). El porcentaje de mutaciones fue 18.5% en carcinomas y 22,6...

  1. Relationship of KRAS and PIK3CA gene mutation in colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    Fan-Bao Yao; Qian-Yi Kuang; Xi Fu; Shi-Yao Huang

    2016-01-01

    Objective:To analyze the relationship between KRAS/PIK3CA gene mutation and clinicopathologic characteristics such as gender, age, tumor location, pathological pattern, histological grade, TNM stage and lymph node metastasis, especially the relationship with distant metastasis of colorectal cancer.Methods:A total of94 cases of colorectal cancer samples surgically resected in Gastrointestinal Surgery Department of our hospital from January 2012 to August 2015 were collected, DNA was extracted and then KRAS and PIK3CA gene sequencing was carried out; their clinicopathologic characteristics (gender, age, tumor location, pathological pattern, histological grade, TNM stage, lymph node metastasis and distant metastasis) were analyzed, the relationship between KRAS/PIK3CA gene mutation and above factors, especially distant metastasis was analyzed, and statistical analysis processing was conducted; patients received 3-year follow-up, distant metastasis and recurrence were observed, and the number of their cases was counted, statistically analyzed and processed.Results:KRAS gene mutation was not associated with gender, age, tumor location, pathological pattern and histological grade, and significantly associated with distant metastasis, lymph node metastasis and TNM stage; PIK3CA was not associated with gender, age, tumor location, pathological pattern and histological grade, and associated with TNM stage, lymph node metastasis and distant metastasis; 7 cases (7.4%) were with mutation of both KRAS and PIK3CA (double positive), and 55 cases (57.4%) were with no mutation at all (double negative); in double positive cases, 5 cases were with distant metastasis, metastasis rate was 71.4% and higher than that of double negative (16/55, 29.1%), and there were statistical differences; it was found in follow-up that metastasis rate of KRAS mutant type was higher than that of wild type, and differences were statistically significant; recurrence rates of KRAS and PIK3CA mutant type

  2. Étude de la toxicité des extraits foliaires d’Euphorbia guyoniana Boiss. et Reut. (Euphorbiaceae chez Schistocerca gregaria (Forskål, 1775 (Orthoptera-Acrididea

    Directory of Open Access Journals (Sweden)

    A. KEMASSI

    2013-03-01

    Full Text Available Study of the toxicity of the crude acetone leaf extract of Euphorbia guyoniana Boiss. and Reut. (Euphorbiaceae in Schistocerca gregaria (Forskål, 1775 (Orthoptera-Acrididea Abstract-This study examines the effect by ingestion of leaf cabbage sprayed with crude acetone extract of Euphorbia guyoniana leaves harvested in the Algerian Sahara on some biological parameters of larvae L5 and adult of desert locusts. The ingestion of cabbage leaves soaked in acetone extract of this Saharan plant generates a 100% mortality in larvae L5 and 66,67% for adult. A significant reduction in food intake was observed in the treated population compared to the control population. It results in a loss of exceptional weight ranging from 26,93% in larvae L5 to 33,09% in adults. Difficulties and anomalies are observed in moulting 16,66% of larvae L5 fed with cabbage leaves soaked in leaf extract of E. guyoniana. Dissection of adult females of the lot processing allows the observation of body regression demonstrating the depressant action of this extract on ovocyte cycle in the desert locust.

  3. Otomi de San Andres Cuexcontitlan, Estado de Mexico (Otomi of San Andres Cuexcontitlan, State of Mexico).

    Science.gov (United States)

    Lastra, Yolanda

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Otomi, an indigenous language of Mexico spoken in San Andres Cuexcontitlan, in the state of Mexico. The objective of collecting such a representative…

  4. Andres Võsand: hakkan ilmselt elukutseliseks kunstnikuks / Andres Võsand ; intervjueerinud Veiko Visnapuu

    Index Scriptorium Estoniae

    Võsand, Andres, 1966-

    2010-01-01

    Intervjuu Saksaamaal elava tennisisti Andres Võsandiga, kelle maalinäitus "Värvireisid" on avatud Kadriorus Kastellaanimaja Galeriis 30.10-28.11.2010. Tegelemisest maalikunstiga, näitusest, reisidest inspireeritud loomingust, tööst tennisetreenerina, tennisekarjäärist. Andmeid A. Võsandi elukäigu kohta

  5. Genetic alterations of the PIK3CA oncogene in human oral squamous cell carcinoma in an Indian population.

    Science.gov (United States)

    Shah, Sejal; Shah, Siddharth; Padh, Harish; Kalia, Kiran

    2015-11-01

    The phosphatidylinositol 3-kinase (PIK3) genes, which code for heterodimeric lipid kinases, consist of a catalytic subunit, p110α (PIK3CA), which regulates cell proliferation, apoptosis, and metastasis. Recently, a high frequency of somatic mutations was observed in the PIK3CA gene in various cancer types, including oral squamous cell carcinoma (OSCC). This study aimed to determine the frequency of oncogenic hotspot mutations in exons 9 and 20 of the PIK3CA gene and its correlation with the clinical characteristics of OSCC patients in an Indian population. We analyzed exons 9 and 20 of the PIK3CA gene using polymerase chain reaction (PCR) and direct genomic sequencing of 50 OSCC primary tumors. We observed two hotspot oncogenic mutations (E542 K, E545 K) in exon 9 and two synonymous mutations (A994 A, T1025 T) in exon 20. Moreover, we identified two single nucleotide polymorphisms (SNPs), rs114587137 (C>T) and rs17849071 (T>G), in intron 9 of the PIK3CA gene. Both oncogenic hotspot mutations were reported primarily in patients with advanced-stage cancer of the buccal mucosa. We have observed a 4% oncogenic mutation frequency of the PIK3CA gene, which plays a minor role in the development of OSCC in an Indian population. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

    Directory of Open Access Journals (Sweden)

    Shun Liang

    Full Text Available The Phosphatidylinositol 3'-kinase is a key regulator in various cancer-associated signal transduction pathways. Genetic alterations of its catalytic subunit alpha, PIK3CA, have been identified in ovarian cancer. Our in vivo data suggests that PIK3CA activation is one of the early genetic events in ovarian cancer. However, its role in malignant transformation of ovarian surface epithelium (OSE is largely unclear.Using the Müllerian inhibiting substance type II receptor (MISIIR promoter, we generated transgenic mice that expressed activated PIK3CA in the Müllerian epithelium. Overexpression of PIK3CA in OSE induced remarkable hyperplasia, but was not able to malignantly transform OSE in vivo. The consistent result was also observed in primary cultured OSEs. Although enforced expression of PIK3CA could not induce OSE anchorage-independent growth, it significantly increased anchorage-independent growth of OSE transformed by mutant K-ras.While PIK3CA activation may not be able to initiate OSE transformation, we conclude that activation of PIK3CA may be an important molecular event contributing to the maintenance of OSE transformation initiated by oncogenes such as K-ras.

  7. MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yihui [Department of Colorectal Surgery, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Road, 150081 Harbin (China); Tang, Qingchao [Cancer Center, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086 Harbin (China); Li, Mingqi; Jiang, Shixiong [Department of Colorectal Surgery, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Road, 150081 Harbin (China); Wang, Xishan, E-mail: wxshan12081@163.com [Cancer Center, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086 Harbin (China)

    2014-02-07

    Highlights: • miR-375 is downregulated in colorectal cancer cell lines and tissues. • miR-375 inhibits colorectal cancer cell growth by targeting PIK3CA. • miR-375 inhibits colorectal cancer cell growth in xenograft nude mice model. - Abstract: Colorectal cancer (CRC) is the second most common cause of death from cancer. MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by triggering RNA degradation or interfering with translation. Aberrant miRNA expression is involved in human disease including cancer. Herein, we showed that miR-375 was frequently down-regulated in human colorectal cancer cell lines and tissues when compared to normal human colon tissues. PIK3CA was identified as a potential miR-375 target by bioinformatics. Overexpression of miR-375 in SW480 and HCT15 cells reduced PIK3CA protein expression. Subsequently, using reporter constructs, we showed that the PIK3CA untranslated region (3′-UTR) carries the directly binding site of miR-375. Additionally, miR-375 suppressed CRC cell proliferation and colony formation and led to cell cycle arrest. Furthermore, miR-375 overexpression resulted in inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. SiRNA-mediated silencing of PIK3CA blocked the inhibitory effect of miR-375 on CRC cell growth. Lastly, we found overexpressed miR-375 effectively repressed tumor growth in xenograft animal experiments. Taken together, we propose that overexpression of miR-375 may provide a selective growth inhibition for CRC cells by targeting PI3K/Akt signaling pathway.

  8. [Health levels in San Andres Cholula].

    Science.gov (United States)

    Alvarez Martinez, A; Corro Fernandez, G; Balmaceda, M

    1991-12-01

    In matters of health and curing, the community of San Andres Cholula in Puebla, Mexico, demonstrates a syncretism similar to religious syncretism. Perspectives on illness and health consistent with the traditional medical practices of curanderos coexist with modern medical practices. Curanderos and physicians often treat the same patients. A curandero's powers are viewed as a special gift transmitted by God or the saints during a dream. The curandero effects a cure not only through knowledge of the medicinal plants, rites, and ceremonies, but by understanding the context of the patient. The Western medical concept of disease emphasizes a biological model and technological control, to the detriment of mental, behavioral, and social factors and determinants. The traditional medical concept stresses the relationship of the individual to the social and ecological environment. Improvements in life expectancy in the developing countries in recent years have been attributed to improved levels of living or to importation of vaccination programs, antibiotics, and similar technologies from the developed countries. The vital register of San Andres Cholula records many deaths whose cause cannot be easily interpreted according to the World Health Organization International Classification of Diseases. It is clear, however, that the root cause of many deaths is malnutrition. The proportion of deaths caused by infectious diseases has declined in Mexico since 1940, but Puebla is still included among the states with the highest incidence. There are great regional and rural-urban mortality differentials in Mexico. In the past 50 years, the infant mortality rate has declined from 250 to 40/1000 live births in San Andres Cholula, more as a result of vaccination campaigns than of improved levels of living. 89% of children have been vaccinated, but the population still lives in about the same state of material comfort as it has for generations except that most households have televisions

  9. Segmental overgrowth syndrome due to an activating PIK3CA mutation identified in affected muscle tissue by exome sequencing

    DEFF Research Database (Denmark)

    Rasmussen, Maria; Sunde, Lone; Weigert, Karen Petra

    2014-01-01

    Mosaic PIK3CA-mutations have been described in an increasing number of overgrowth syndromes. We describe a patient with a previously unreported segmental overgrowth syndrome with the mutation, PIKCA3 c.3140A>G (p.His1047Arg) in affected tissue diagnosed by exome sequencing. This PIK3CA-associated......-associated segmental overgrowth syndrome overlaps with CLOVES syndrome and fibroadipose hyperplasia but is distinct from each of these entities....

  10. An integrative genomic and proteomic analysis of PIK3CA, PTEN and AKT mutations in breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Stemke-Hale, Katherine; Gonzalez-Angulo, Ana Maria; Lluch, Ana; Neve, Richard M.; Kuo, Wen-Lin; Davies, Michael; Carey, Mark; Hu, Zhi; Guan, Yinghui; Sahin, Aysegul; Symmans, W. Fraser; Pusztai, Lajos; Nolden, Laura K.; Horlings, Hugo; Berns, Katrien; Hung, Mien-Chie; van de Vijver, Marc J.; Valero, Vicente; Gray, Joe W.; Bernards, Rene; Mills, Gordon B.; Hennessy, Bryan T.

    2008-05-06

    Phosphatidylinositol-3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT and PTEN mutations, and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in-vitro and on outcome after adjuvant tamoxifen. PIK3CA mutations were more common in hormone receptor positive (33.8%) and HER2-positive (24.6%) than in basal-like tumors (8.3%). AKT1 (1.4%) and PTEN (2.3%) mutations were restricted to hormone receptor-positive cancers with PTEN protein levels also being significantly lower in hormone receptor-positive cancers. Unlike AKT1 mutations, PIK3CA (39%) and PTEN (20%) mutations were more common in cell lines than tumors, suggesting a selection for these but not AKT1 mutations during adaptation to culture. PIK3CA mutations did not have a significant impact on outcome in 166 hormone receptor-positive breast cancer patients after adjuvant tamoxifen. PIK3CA mutations, in comparison with PTEN loss and AKT1 mutations, were associated with significantly less and indeed inconsistent activation of AKT and of downstream PI3K/AKT signaling in tumors and cell lines, and PTEN loss and PIK3CA mutation were frequently concordant, suggesting different contributions to pathophysiology. PTEN loss but not PIK3CA mutations rendered cells sensitive to growth inhibition by the PI3K inhibitor LY294002. Thus, PI3K pathway aberrations likely play a distinct role in the pathogenesis of different breast cancer subtypes. The specific aberration may have implications for the selection of PI3K-targeted therapies in hormone receptor-positive breast cancer.

  11. The Inhibitory Effect of PIK-75 on Inflammatory Mediator Response Induced by Hydrogen Peroxide in Feline Esophageal Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Jun Yeong Jeong

    2014-01-01

    Full Text Available Isoform-selective inhibitors of phosphoinositide 3-kinase (PI3K activation have an anti-inflammatory effect by reducing proinflammatory cytokines. Cultured feline esophageal epithelial cells (EEC of passages 3~4 were treated with hydrogen peroxide and PIK-75. The cell viability was measured by a MTT incorporation assay. The distribution of PI3K isoforms, p-Akt, IL-1β, and IL-8 was inferred from Western blots. The release of IL-6 was determined by ELISA. The cell morphology was not considerably different from nontreated cells if the cells were pretreated with PIK-75 and treated with 300 μM hydrogen peroxide. The density of p110α of PI3K was increased, but that of other types was not affected after the treatment with hydrogen peroxide. The density of p-Akt, when the cells were exposed to PIK-75 and hydrogen peroxide, was diminished dose dependently more than that of hydrogen peroxide treatment only. The decrease of p-Akt showed an inhibition of PI3K by PIK-75. PIK-75 dose dependently reduced the expression of IL-1β, IL-8, and the level of IL-6 compared with hydrogen peroxide treatment only. These results suggest evidence that p110α mediates esophageal inflammation and that PIK-75 has an anti-inflammatory effect by reducing proinflammatory cytokines on feline esophageal epithelial cultured cells.

  12. Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway.

    Science.gov (United States)

    Lou, Hong; Villagran, Guillermo; Boland, Joseph F; Im, Kate M; Polo, Sarita; Zhou, Weiyin; Odey, Ushie; Juárez-Torres, Eligia; Medina-Martínez, Ingrid; Roman-Basaure, Edgar; Mitchell, Jason; Roberson, David; Sawitzke, Julie; Garland, Lisa; Rodríguez-Herrera, Maria; Wells, David; Troyer, Jennifer; Pinto, Francisco Castillo; Bass, Sara; Zhang, Xijun; Castillo, Miriam; Gold, Bert; Morales, Hesler; Yeager, Meredith; Berumen, Jaime; Alvirez, Enrique; Gharzouzi, Eduardo; Dean, Michael

    2015-12-01

    Cervical cancer is one of the most common causes of cancer mortality for women living in poverty, causing more than 28,000 deaths annually in Latin America and 266,000 worldwide. To better understand the molecular basis of the disease, we ascertained blood and tumor samples from Guatemala and Venezuela and performed genomic characterization. We performed human papillomavirus (HPV) typing and identified somatically mutated genes using exome and ultra-deep targeted sequencing with confirmation in samples from Mexico. Copy number changes were also assessed in the exome sequence. Cervical cancer cases in Guatemala and Venezuela have an average age of diagnosis of 50 years and 5.6 children. Analysis of 675 tumors revealed activation of PIK3CA and other PI3K/AKT pathway genes in 31% of squamous carcinomas and 24% of adeno- and adenosquamous tumors, predominantly at two sites (E542K, E545K) in the helical domain of the PIK3CA gene. This distribution of PIK3CA mutations is distinct from most other cancer types and does not result in the in vitro phosphorylation of AKT. Somatic mutations were more frequent in squamous carcinomas diagnosed after the age of 50 years. Frequent gain of chromosome 3q was found, and low PIK3CA mutation fractions in many tumors suggest that PI3K mutation can be a late event in tumor progression. PI3K pathway mutation is important to cervical carcinogenesis in Latin America. Therapeutic agents that directly target PI3K could play a role in the therapy of this common malignancy. ©2015 American Association for Cancer Research.

  13. Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway

    Science.gov (United States)

    Lou, Hong; Villagran, Guillermo; Boland, Joseph F.; Im, Kate M.; Polo, Sarita; Zhou, Weiyin; Odey, Ushie; Juárez-Torres, Eligia; Medina-Martínez, Ingrid; Roman-Basaure, Edgar; Mitchell, Jason; Roberson, David; Sawitzke, Julie; Garland, Lisa; Rodríguez-Herrera, Maria; Wells, David; Troyer, Jennifer; Pinto, Francisco Castillo; Bass, Sara; Zhang, Xijun; Castillo, Miriam; Gold, Bert; Morales, Hesler; Yeager, Meredith; Berumen, Jaime; Alvirez, Enrique; Gharzouzi, Eduardo; Dean, Michael

    2015-01-01

    Purpose Cervical cancer is one of the most common causes of cancer mortality for women living in poverty, causing over 28,000 deaths annually in Latin America and 266,000 worldwide. To better understand the molecular basis of the disease we ascertained blood and tumor samples from Guatemala and Venezuela and performed genomic characterization. Experimental Design We performed HPV typing and identified somatically mutated genes using exome and ultra-deep targeted sequencing with confirmation in samples from Mexico. Copy number changes were also assessed in the exome sequence. Results Cervical cancer cases in Guatemala and Venezuela have an average age-of-diagnosis of 50 years, and 5.6 children. Analysis of 675 tumors revealed activation of PIK3CA and other phosphatidyl inositol (PI3K)/AKT pathway genes in 31% of squamous carcinomas and 24% of adeno- and adenosquamous tumors, predominantly at two sites (E542K, E545K) in the helical domain of the PIK3CA gene. This distribution of PIK3CA mutations is distinct from most other cancer types, and does not result in the in vitro phosphorylation of AKT. Somatic mutations were more frequent in squamous carcinomas diagnosed after age 50. Frequent gain of chromosome 3q was found and low PIK3CA mutation fractions in many tumors suggest that PI3K mutation can be a late event in tumor progression. Conclusions PI3K pathway mutation is important to cervical carcinogenesis in Latin America. Therapeutic agents that directly target PI3K could play a role in the therapy of this common malignancy. PMID:26080840

  14. Eesti Energia esindused = Eesti Energia branches / Andres Labi, Janno Roos

    Index Scriptorium Estoniae

    Labi, Andres, 1977-

    2013-01-01

    Eesti Energia klienditeeninduse kontorite sisekujundusest. Autorid: Janno Roos, Andres Labi ja Liisa Põime (Ruumilabor). Visuaalne identiteet: Tank.Teenuste disain: Urmas Pastarus. ESLi aastapreemiate žürii esimehe Kaido Kivi ning žürii liikme Raivo Puusepa arvamused

  15. "Vettpidavad allikad" = "Watertight sources" / Janno Roos, Andres Labi

    Index Scriptorium Estoniae

    Roos, Janno, 1976-

    2013-01-01

    Eesti Ajaloomuuseumis avatud näituse kujundasid Janno Roos ja Andres Labi (Ruumilabor). Kuraator Krista Sarv. Graafiline disain: Identity. Eksponeeritud allveeuuringute käigus leitu. Arhitektuuriajaloolase Leele Välja arvamus

  16. Jumalaema kiriku kellamees tuli Tartu Toome varemetesse / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    13. juulil esietendus Emajõe Suveteatris "Jumalaema kiriku kellamees". Victor Hugo romaani järgi tegi instseneeringu Urmas Lennuk, lavastaja Andres Dvinjaninov. Mängitakse Tartu Toomkiriku varemetes

  17. Prognostic role of PIK3CA mutations of cell-free DNA in early-stage triple negative breast cancer.

    Science.gov (United States)

    Takeshita, Takashi; Yamamoto, Yutaka; Yamamoto-Ibusuki, Mutsuko; Inao, Toko; Sueta, Aiko; Fujiwara, Saori; Omoto, Yoko; Iwase, Hirotaka

    2015-11-01

    PIK3CA is an oncogene that encodes the p110α component of phosphatidylinositol 3-kinase (PI3K); it is the second most frequently mutated gene following the TP53 gene. In the clinical setting, PIK3CA mutations may have favorable prognostic value for hormone receptor-positive breast cancer patients and, during the past few years, PIK3CA mutations of cell-free DNA (cfDNA) have attracted attention as a potential noninvasive biomarker of cancer. However, there are few reports on the clinical implications of PIK3CA mutations for TNBC patients. We investigated the PIK3CA major mutation status of cfDNA as a noninvasive biomarker of cancer using droplet digital polymerase chain reaction (ddPCR), which has high level sensitivity and specificity for cancer mutation, in early-stage 49 triple negative breast cancer (TNBC) patients. A total of 12 (24.4%) of 49 patients had PIK3CA mutations of cfDNA. In a median follow up of 54.4 months, the presence of PIK3CA mutations of cfDNA had significant impacts on relapse-free survival (RFS; P = 0.0072) and breast cancer-specific survival (BCSS; P = 0.016), according to the log-lank test. In a Cox proportional hazards model, the presence of PIK3CA mutations of cfDNA had significant prognostic value in the univariate and multivariate analysis. Additionally, the presence of PIK3CA mutations of cfDNA was significantly correlated with positive androgen receptor phosphorylated form depending on PI3K signaling pathway (pAR) which is independent favorable prognostic factors of TNBC. We demonstrated that the presence of PIK3CA major mutations of cfDNA could be a discriminatory predictor of RFS and BCSS in early-stage TNBC patients and it was associated with PI3K pathway-dependent AR phosphorylation. © 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

  18. Andres Tolts 60 : omanäoliste vaikelude imeline maailm / Andres Tolts ; intervjueerinud Tiina Kolk ; kommenteerinud Jaan Elken

    Index Scriptorium Estoniae

    Tolts, Andres, 1949-2014

    2009-01-01

    Andres Toltsi näitused "Asjad" Hobusepea galeriis 12. oktoobrini, "Näitus" Tallinna Kunstihoones 25. oktoobrini, "Varane Tolts" Haus galeriis 13. novembrini. Pikemalt näitusest "Näitus", kuraator Harry Liivrand

  19. Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer*

    Science.gov (United States)

    Young, Christian D.; Zimmerman, Lisa J.; Hoshino, Daisuke; Formisano, Luigi; Hanker, Ariella B.; Gatza, Michael L.; Morrison, Meghan M.; Moore, Preston D.; Whitwell, Corbin A.; Dave, Bhuvanesh; Stricker, Thomas; Bhola, Neil E.; Silva, Grace O.; Patel, Premal; Brantley-Sieders, Dana M.; Levin, Maren; Horiates, Marina; Palma, Norma A.; Wang, Kai; Stephens, Philip J.; Perou, Charles M.; Weaver, Alissa M.; O'Shaughnessy, Joyce A.; Chang, Jenny C.; Park, Ben Ho; Liebler, Daniel C.; Cook, Rebecca S.; Arteaga, Carlos L.

    2015-01-01

    Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K) have been shown to transform human mammary epithelial cells (MECs). These mutations are present in all breast cancer subtypes, including basal-like breast cancer (BLBC). Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified 72 protein expression changes in human basal-like MECs with knock-in E545K or H1047R PIK3CA mutations versus isogenic MECs with wild-type PIK3CA. Several of these were secreted proteins, cell surface receptors or ECM interacting molecules and were required for growth of PIK3CA mutant cells as well as adjacent cells with wild-type PIK3CA. The proteins identified by MS were enriched among human BLBC cell lines and pointed to a PI3K-dependent amphiregulin/EGFR/ERK signaling axis that is activated in BLBC. Proteins induced by PIK3CA mutations correlated with EGFR signaling and reduced relapse-free survival in BLBC. Treatment with EGFR inhibitors reduced growth of PIK3CA mutant BLBC cell lines and murine mammary tumors driven by a PIK3CA mutant transgene, all together suggesting that PIK3CA mutations promote tumor growth in part by inducing protein changes that activate EGFR. PMID:25953087

  20. Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer.

    Science.gov (United States)

    Young, Christian D; Zimmerman, Lisa J; Hoshino, Daisuke; Formisano, Luigi; Hanker, Ariella B; Gatza, Michael L; Morrison, Meghan M; Moore, Preston D; Whitwell, Corbin A; Dave, Bhuvanesh; Stricker, Thomas; Bhola, Neil E; Silva, Grace O; Patel, Premal; Brantley-Sieders, Dana M; Levin, Maren; Horiates, Marina; Palma, Norma A; Wang, Kai; Stephens, Philip J; Perou, Charles M; Weaver, Alissa M; O'Shaughnessy, Joyce A; Chang, Jenny C; Park, Ben Ho; Liebler, Daniel C; Cook, Rebecca S; Arteaga, Carlos L

    2015-07-01

    Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K) have been shown to transform human mammary epithelial cells (MECs). These mutations are present in all breast cancer subtypes, including basal-like breast cancer (BLBC). Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified 72 protein expression changes in human basal-like MECs with knock-in E545K or H1047R PIK3CA mutations versus isogenic MECs with wild-type PIK3CA. Several of these were secreted proteins, cell surface receptors or ECM interacting molecules and were required for growth of PIK3CA mutant cells as well as adjacent cells with wild-type PIK3CA. The proteins identified by MS were enriched among human BLBC cell lines and pointed to a PI3K-dependent amphiregulin/EGFR/ERK signaling axis that is activated in BLBC. Proteins induced by PIK3CA mutations correlated with EGFR signaling and reduced relapse-free survival in BLBC. Treatment with EGFR inhibitors reduced growth of PIK3CA mutant BLBC cell lines and murine mammary tumors driven by a PIK3CA mutant transgene, all together suggesting that PIK3CA mutations promote tumor growth in part by inducing protein changes that activate EGFR. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  1. A systematic study of gene mutations in urothelial carcinoma; inactivating mutations in TSC2 and PIK3R1.

    Directory of Open Access Journals (Sweden)

    Gottfrid Sjödahl

    Full Text Available BACKGROUND: Urothelial carcinoma (UC is characterized by frequent gene mutations of which activating mutations in FGFR3 are the most frequent. Several downstream targets of FGFR3 are also mutated in UC, e.g., PIK3CA, AKT1, and RAS. Most mutation studies of UCs have been focused on single or a few genes at the time or been performed on small sample series. This has limited the possibility to investigate co-occurrence of mutations. METHODOLOGY/PRINCIPAL FINDINGS: We performed mutation analyses of 16 genes, FGFR3, PIK3CA, PIK3R1 PTEN, AKT1, KRAS, HRAS, NRAS, BRAF, ARAF, RAF1, TSC1, TSC2, APC, CTNNB1, and TP53, in 145 cases of UC. We show that FGFR3 and PIK3CA mutations are positively associated. In addition, we identified PIK3R1 as a target for mutations. We demonstrate a negative association at borderline significance between FGFR3 and RAS mutations, and show that these mutations are not strictly mutually exclusive. We show that mutations in BRAF, ARAF, RAF1 rarely occurs in UC. Our data emphasize the possible importance of APC signaling as 6% of the investigated tumors either showed inactivating APC or activating CTNNB1 mutations. TSC1, as well as TSC2, that constitute the mTOR regulatory tuberous sclerosis complex were found to be mutated at a combined frequency of 15%. CONCLUSIONS/SIGNIFICANCE: Our data demonstrate a significant association between FGFR3 and PIK3CA mutations in UC. Moreover, the identification of mutations in PIK3R1 further emphasizes the importance of the PI3-kinase pathway in UC. The presence of TSC2 mutations, in addition to TSC1 mutations, underlines the involvement of mTOR signaling in UC.

  2. PIK3CB and K-ras in oral squamous Cell carcinoma. A possible cross-talk!

    Directory of Open Access Journals (Sweden)

    Natheer H Al-Rawi

    2014-01-01

    Full Text Available Background: PIK3 and K-ras are signal transducing proteins involved and mediating many responses related to cell cycle growth regulation. Until date, there has been only limited evidence about the expression of K-ras and PKI3CB in oral squamous cell carcinoma (OSCC. AIMS : This study aimed to examine both proteins in OSCC and their relation to clinic- pathological findings. Setting and Design: A total of 31 formalin-fixed paraffin-embedded specimens of OSCC were selected in this study. PIK3CB and K-ras expressions were detected using standard immunohistochemical techniques. Materials and Methods: PIK3CB and k-ras immune reactivity was semi-quantitatively evaluated in at least five representative fields at 400X magnification and recorded as percentage of PIK3CB and k-ras positive tumor cells over the total number of cells examined in the same area. Results and Conclusion: All examined specimens of OSCC were positive for monoclonal antibodies directed against PIK3CB and K-ras proteins especially at advanced stage of the disease. No significant relation was observed between the tested proteins and the clinic-pathological findings of OSCC; however a highly significant direct relationship was observed between K-ras and PIK3CB. This lead to conclusion that both K-ras and PIK3CB signaling pathway were activated in the advanced stage of OSCC, and possibly a cross-talk between them. This could make these mutant proteins a potential target for an effective molecular therapy.

  3. Demodex og andre ektoparasitter hos danske katte

    DEFF Research Database (Denmark)

    Memborg Jensen, Mia C.; Boysen, Lene; Thamsborg, Stig Milan

    2015-01-01

    Raske katte og katte med hudforandringer blev undersøgt for at belyse forekomst og betydning af Demodex. En tredje gruppe af aflivede vild- og tamkatte blev desuden undersøgt for forekomst af andre ektoparasitter. Forskellige diagnostiske teknikker blev anvendt og evalueret i undersøgelsen. I alt...... indgik 176 katte, som blev undersøgt ved hårpluk, hudskrab, tapetest, flotation affæcesprøve, øreskrab samt kæmning af pelsen. Demodex spp. blev fundet hos tre katte, og hos én af disse blev iagttaget klinisk demodicose. Demodex spp. blev ikke påvist i gruppen af raske katte. Den samlede forekomst af...... ektoparasitter hos de aflivede vild-og tamkatte var 57%. Følgende ektoparasitter blev påvist: Ctenocephalidesfelis felis, Otodectes cynotis, Ixodes spp., Felicola subrostrata,Cheyletiella blakei og Demodex spp.. Alle de anvendte diagnostiske teknikker var effektive til påvisningen af forskellige ektoparasitter...

  4. UCN sources at external beams of thermal neutrons. An example of PIK reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lychagin, E.V., E-mail: lychag@nf.jinr.ru [Joint Institute for Nuclear Research, 6 Joliot-Curie, Dubna 141980 (Russian Federation); Mityukhlyaev, V.A., E-mail: victim@pnpi.spb.ru [Petersburg Nuclear Physics Institute, Orlova Roscha, Gatchina 188300 (Russian Federation); Muzychka, A.Yu., E-mail: muz@nf.jinr.ru [Joint Institute for Nuclear Research, 6 Joliot-Curie, Dubna 141980 (Russian Federation); Nekhaev, G.V., E-mail: grigorijnekhaev@yandex.ru [Joint Institute for Nuclear Research, 6 Joliot-Curie, Dubna 141980 (Russian Federation); Nesvizhevsky, V.V., E-mail: nesvizhevsky@ill.eu [Institut Max von Laue – Paul Langevin, 71 Avenue des Martyrs, Grenoble 38042 (France); Onegin, M.S., E-mail: oneginm@gmail.com [Petersburg Nuclear Physics Institute, Orlova Roscha, Gatchina 188300 (Russian Federation); Sharapov, E.I., E-mail: sharapov@nf.jinr.ru [Joint Institute for Nuclear Research, 6 Joliot-Curie, Dubna 141980 (Russian Federation); Strelkov, A.V., E-mail: str@jinr.ru [Joint Institute for Nuclear Research, 6 Joliot-Curie, Dubna 141980 (Russian Federation)

    2016-07-01

    We consider ultracold neutron (UCN) sources based on a new method of UCN production in superfluid helium ({sup 4}He). The PIK reactor is chosen as a perspective example of application of this idea, which consists of installing {sup 4}He UCN source in the beam of thermal or cold neutrons and surrounding the source with moderator-reflector, which plays the role of cold neutron (CN) source feeding the UCN source. CN flux in the source can be several times larger than the incident flux, due to multiple neutron reflections from the moderator–reflector. We show that such a source at the PIK reactor would provide an order of magnitude larger density and production rate than an analogous source at the ILL reactor. We estimate parameters of {sup 4}He source with solid methane (CH{sub 4}) or/and liquid deuterium (D{sub 2}) moderator–reflector. We show that such a source with CH{sub 4} moderator–reflector at the PIK reactor would provide the UCN density of ~1·10{sup 5} cm{sup −3}, and the UCN production rate of ~2·10{sup 7} s{sup −1}. These values are respectively 1000 and 20 times larger than those for the most intense UCN user source. The UCN density in a source with D{sub 2} moderator-reflector would reach the value of ~2·10{sup 5} cm{sup −3}, and the UCN production rate would be equal ~8·10{sup 7} s{sup −1}. Installation of such a source in a beam of CNs would slightly increase the density and production rate.

  5. Oncogenic mutations of PIK3CA and HRAS in carcinoma of cervix in South Indian women

    Directory of Open Access Journals (Sweden)

    Geetha kumari Konathala

    2017-12-01

    Full Text Available Carcinoma of the cervix is the second most successive reason of female cancer which remains an imperative medical issue in women around the world. Mutations are normally dissected by tissue biopsy which is intrusive, costly and possibly subjective. However, detection of mutations from blood is a non-invasive procedure. However, detection of mutations from blood is a non-invasive procedure. It would offer several advantages, including greater speed and cheap at a cost such that the family members can likewise be screened. Repeated tests after surgery provide an early cautioning for the disease recurrence. The present work aimed to assess the frequency of PIK3CA and HRAS mutations in cervical cancer patients using peripheral blood. This study includes 210 cases presenting cervical cancer and 210 age and sex-matched healthy controls. Genomic DNA was isolated from peripheral blood. The PCR-CTPP method was performed for screening of exons 9 and 20 of PIK3CA and exon 34 HRAS mutations. Sequencing of PIK3CA and of HRAS genes was done for further confirmation. Out of eight mutations studied, no clear disease causing mutations were noticed in any of the cervical cancer patients in the present investigation. Cervical cancer harbors excessive rates of targetable oncogenic mutations. We couldn't find any changes in our investigation. If a connection amongst tissue and non-tissue mutations could be shown, the probability of a basic blood test to distinguish possibility for anticancer treatment comes a bit nearer. Repeated blood tests after surgery provide an early cautioning for disease recurrence. Therefore, in future evaluation of a larger data set and cases with progressive tumor (Stage III–IV will be required to approve these findings.

  6. Andres Tali sõnavõtt ettekannete päeval = Andres Tali's speech given on the lecture day / Andres Tali

    Index Scriptorium Estoniae

    Tali, Andres, 1956-

    2006-01-01

    Kaasaegse Kunsti Eesti Keskuse ettekannete päev "Kunstnike moraalsed valikud kultuurikonfliktides" 27.04.2006 Tallinna Kunstihoones. Oma installatsioonist "Pastoraalne pastishsh" ning videost "Vägivald ja propaganda - The Movie" samas 8.04.-28.05.2006 avatud Elin Kardi, Marko Mäetamme, Marco Laimre ja Andres Tali ühisnäitusel "Vägivald ja propaganda"

  7. Politseiharidus - koolid koos või lahus? / Andres Anvelt

    Index Scriptorium Estoniae

    Anvelt, Andres, 1969-

    2004-01-01

    Sisekaitseakadeemia politseikolledži ja Politseikooli ühendamise põhjustest ja eesmärkidest. Liitmise tulemusena tekib Eestisse ühtne politseikoolitussüsteem, mis võimaldab ühtlustada õppekavad, -metoodika ja -kvaliteedi ning kasutada efektiivsemalt ressursse. Kommenteerivad Toivo Maimets, Raivo Õpik, Peeter Järvelaid, Jaanus Rahumägi ja Jüri Merits

  8. p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC.

    Science.gov (United States)

    Kidacki, Michal; Lehman, Heather L; Green, Michelle V; Warrick, Joshua I; Stairs, Douglas B

    2017-10-01

    Despite recent improvements in treatment for head and neck squamous cell carcinoma (HNSCC), half of all patients with a regional or advanced disease will die within 5 years from diagnosis. Therefore, identification of mechanisms driving the aggressive behavior of HNSCC is of utmost importance. Because p120-catenin (CTNND1/P120CTN) downregulation and PIK3CA mutations are commonly found in HNSCC, the objective of this study was to identify their impact on fundamental processes of metastasis, specifically, migration and invasion. Furthermore, this study aimed to identify the key effector proteins regulated by P120CTN downregulation and PIK3CA mutations. Studies using oral keratinocytes demonstrated that P120CTN downregulation and PIK3CA mutations increased migration and invasion. In addition, P120CTN downregulation and PIK3CA mutations resulted in elevated matrix metallopeptidase 1 (MMP1) levels. Inhibition of MMP1 resulted in decreased invasion, suggesting that MMP1 plays a critical role in HNSCC invasion. Moreover, analysis of HNSCC patient specimens from The Cancer Genome Atlas confirmed these findings. Tumors with low P120CTN and PI3K pathway mutations have higher levels of MMP1 compared to tumors with high P120CTN and no PI3K pathway mutations. In conclusion, this study demonstrates that P120CTN downregulation and PIK3CA mutations promote MMP1-driven invasion, providing a potential novel target for limiting metastasis in HNSCC.Implications: Because of its role in invasion, MMP1 represents a novel, potential target for limiting metastasis in a subset of HNSCCs with P120CTN downregulation and PIK3CA mutations. Mol Cancer Res; 15(10); 1398-409. ©2017 AACR. ©2017 American Association for Cancer Research.

  9. Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC

    Directory of Open Access Journals (Sweden)

    Shi Bingyin

    2011-04-01

    Full Text Available Abstract Background Lung cancer is the leading cause of cancer-related death worldwide. Genetic and epigenetic alterations have been identified frequently in lung cancer, such as promoter methylation, gene mutations and genomic amplification. However, the interaction between genetic and epigenetic events and their significance in lung tumorigenesis remains poorly understood. Methods We determined the promoter methylation of 6 genes and PIK3CA amplification using quantitative methylation-specific PCR (Q-MSP and real-time quantitative PCR, respectively, and explore the association of promoter methylation with PIK3CA amplification in a large cohort of clinically well-characterized non-small cell lung cancer (NSCLC. Results Highly frequent promoter methylation was observed in NSCLC. With 100% diagnostic specificity, excellent sensitivity, ranging from 45.8 to 84.1%, was found for each of the 6 genes. The promoter methylation was associated with histologic type. Methylation of CALCA, CDH1, DAPK1, and EVX2 was more common in squamous cell carcinomas (SCC compared to adenocarcinomas (ADC. Conversely, there was a trend toward a higher frequency of RASSF1A methylation in ADC than SCC. In addition, PIK3CA amplification was frequently found in NSCLC, and was associated with certain clinicopathologic features, such as smoking history, histologic type and pleural indentation. Importantly, aberrant promoter methylation of certain genes was significantly associated with PIK3CA amplification. Conclusions Our data showed highly frequent promoter methylation and PIK3CA amplification in Chinese NSCLC population, and first demonstrated the associations of gene methylation with PIK3CA amplification, suggesting that these epigenetic events may be a consequence of overactivation of PI3K/Akt pathway.

  10. André Danjon et l'informatique.

    Science.gov (United States)

    Arsac, J.

    There is not any paper by André Danjon about computer science. The only way to know his ideas about it is through his action. At the end of the fifties, several scientists in astronomy and astrophysics had been convinced that a computer would be of great help in their research works. André Danjon immediatly agreed that it was a good idea. He greatly supported them in the process of having a computer bought by the Meudon Observatory. A computing center was started there in 1959. As soon as 1957, André Danjon had initiated a French association for computing, the "association française de calcul". This association provoked a world meeting of associations for information processing in Paris in 1959, where the IFIPS has been created.

  11. PRKCI negatively regulates autophagy via PIK3CA/AKT–MTOR signaling

    Energy Technology Data Exchange (ETDEWEB)

    Qu, Liujing; Li, Ge; Xia, Dan; Hongdu, Beiqi; Xu, Chentong; Lin, Xin [Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Sciences Center, Beijing (China); Peking University Center for Human Disease Genomics, Peking University, Beijing (China); Chen, Yingyu, E-mail: yingyu_chen@bjmu.edu.cn [Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Sciences Center, Beijing (China); Peking University Center for Human Disease Genomics, Peking University, Beijing (China)

    2016-02-05

    The atypical protein kinase C isoform PRKC iota (PRKCI) plays a key role in cell proliferation, differentiation, and carcinogenesis, and it has been shown to be a human oncogene. Here, we show that PRKCI overexpression in U2OS cells impaired functional autophagy in normal or cell stress conditions, as characterized by decreased levels of light chain 3B-II protein (LC3B-II) and weakened degradation of endogenous and exogenous autophagic substrates. Conversely, PRKCI knockdown by small interference RNA resulted in opposite effects. Additionally, we identified two novel PRKCI mutants, PRKCI{sup L485M} and PRKCI{sup P560R}, which induced autophagy and exhibited dominant negative effects. Further studies indicated that PRKCI knockdown–mediated autophagy was associated with the inactivation of phosphatidylinositol 3-kinase alpha/AKT–mammalian target of rapamycin (PIK3CA/AKT–MTOR) signaling. These data underscore the importance of PRKCI in the regulation of autophagy. Moreover, the finding may be useful in treating PRKCI-overexpressing carcinomas that are characterized by increased levels of autophagy. - Highlights: • The atypical protein kinase C iota isoform (PRKCI) is a human oncogene. • PRKCI overexpression impairs functional autophagy in U2OS cells. • It reduces LC3B-II levels and weakens SQSTM1 and polyQ80 aggregate degradation. • PRKCI knockdown has the opposite effect. • The effect of PRKCI knockdown is related to PIK3CA/AKT–MTOR signaling inactivation.

  12. The Potsdam Parallel Ice Sheet Model (PISM-PIK – Part 1: Model description

    Directory of Open Access Journals (Sweden)

    R. Winkelmann

    2011-09-01

    Full Text Available We present the Potsdam Parallel Ice Sheet Model (PISM-PIK, developed at the Potsdam Institute for Climate Impact Research to be used for simulations of large-scale ice sheet-shelf systems. It is derived from the Parallel Ice Sheet Model (Bueler and Brown, 2009. Velocities are calculated by superposition of two shallow stress balance approximations within the entire ice covered region: the shallow ice approximation (SIA is dominant in grounded regions and accounts for shear deformation parallel to the geoid. The plug-flow type shallow shelf approximation (SSA dominates the velocity field in ice shelf regions and serves as a basal sliding velocity in grounded regions. Ice streams can be identified diagnostically as regions with a significant contribution of membrane stresses to the local momentum balance. All lateral boundaries in PISM-PIK are free to evolve, including the grounding line and ice fronts. Ice shelf margins in particular are modeled using Neumann boundary conditions for the SSA equations, reflecting a hydrostatic stress imbalance along the vertical calving face. The ice front position is modeled using a subgrid-scale representation of calving front motion (Albrecht et al., 2011 and a physically-motivated calving law based on horizontal spreading rates. The model is tested in experiments from the Marine Ice Sheet Model Intercomparison Project (MISMIP. A dynamic equilibrium simulation of Antarctica under present-day conditions is presented in Martin et al. (2011.

  13. Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies

    Science.gov (United States)

    Hanker, Ariella B.; Pfefferle, Adam D.; Balko, Justin M.; Kuba, María Gabriela; Young, Christian D.; Sánchez, Violeta; Sutton, Cammie R.; Cheng, Hailing; Perou, Charles M.; Cook, Rebecca S.; Arteaga, Carlos L.

    2013-01-01

    Human epidermal growth factor receptor 2 (HER2; ERBB2) amplification and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations often co-occur in breast cancer. Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway has been shown to correlate with a diminished response to HER2-directed therapies. We generated a mouse model of HER2-overexpressing (HER2+), PIK3CAH1047R-mutant breast cancer. Mice expressing both human HER2 and mutant PIK3CA in the mammary epithelium developed tumors with shorter latencies compared with mice expressing either oncogene alone. HER2 and mutant PIK3CA also cooperated to promote lung metastases. By microarray analysis, HER2-driven tumors clustered with luminal breast cancers, whereas mutant PIK3CA tumors were associated with claudin-low breast cancers. PIK3CA and HER2+/PIK3CA tumors expressed elevated transcripts encoding markers of epithelial-to-mesenchymal transition and stem cells. Cells from HER2+/PIK3CA tumors more efficiently formed mammospheres and lung metastases. Finally, HER2+/PIK3CA tumors were resistant to trastuzumab alone and in combination with lapatinib or pertuzumab. Both drug resistance and enhanced mammosphere formation were reversed by treatment with a PI3K inhibitor. In sum, PIK3CAH1047R accelerates HER2-mediated breast epithelial transformation and metastatic progression, alters the intrinsic phenotype of HER2-overexpressing cancers, and generates resistance to approved combinations of anti-HER2 therapies. PMID:23940356

  14. PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors.

    Science.gov (United States)

    Dueñas, Marta; Martínez-Fernández, Mónica; García-Escudero, Ramón; Villacampa, Felipe; Marqués, Miriam; Saiz-Ladera, Cristina; Duarte, José; Martínez, Victor; Gómez, M José; Martín, M Luisa; Fernández, Manoli; Castellano, Daniel; Real, Francisco X; Rodriguez-Peralto, Jose L; De La Rosa, Federico; Paramio, Jesús M

    2015-07-01

    Bladder cancer (BC) is the fifth most common cancer in the world, being the non-muscle invasive tumors (NMIBC) the most frequent. NMIBC shows a very high frequency of recurrence and, in certain cases, tumor progression. The phosphatidylinositol 3-kinase (PI3K) pathway, which controls cell growth, tumorigenesis, cell invasion and drug response, is frequently activated in numerous human cancers, including BC, in part through alterations of PIK3CA gene. However, the significance of PIK3CA gene alterations with respect to clinicopathological characteristics, and in particular tumor recurrence and progression, remains elusive. Here, we analyzed the presence of mutations in FGFR3 and PIK3CA genes and copy number alterations of PIK3CA gene in bladder tumor and their correspondent paired normal samples from 87 patients. We observed an extremely high frequency of PIK3CA gene alterations (mutations, copy gains, or both) in tumor samples, affecting primarily T1 and T2 tumors. A significant number of normal tissues also showed mutations and copy gains, being coincident with those found in the corresponding tumor sample. In low-grade tumors PIK3CA mutations associated with FGFR3 mutations. Alterations in PIK3CA gene resulted in increased Akt activity in tumors. Interestingly, the presence of PIK3CA gene alterations, and in particular gene mutations, is significantly associated with reduced recurrence of NMIBC patients. Importantly, the presence of FGFR3 mutations may influence the clinical outcome of patients bearing alterations in PIK3CA gene, and increased recurrence was associated to FGFR3 mutated, PIK3CA wt tumors. These findings may have high relevance in terms of using PI3K-targeted therapies for BC treatment. © 2013 Wiley Periodicals, Inc.

  15. Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer.

    Science.gov (United States)

    Arsenic, Ruza; Treue, Denise; Lehmann, Annika; Hummel, Michael; Dietel, Manfred; Denkert, Carsten; Budczies, Jan

    2015-01-01

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PIK3CA, is one of the most frequently mutated genes in breast cancer, and the mutation status of PIK3CA has clinical relevance related to response to therapy. The aim of our study was to investigate the mutation status of PIK3CA gene and to evaluate the concordance between NGS and SGS for the most important hotspot regions in exon 9 and 20, to investigate additional hotspots outside of these exons using NGS, and to correlate the PIK3CA mutation status with the clinicopathological characteristics of the cohort. In the current study, next-generation sequencing (NGS) and Sanger Sequencing (SGS) was used for the mutational analysis of PIK3CA in 186 breast carcinomas. Altogether, 64 tumors had PIK3CA mutations, 55 of these mutations occurred in exons 9 and 20. Out of these 55 mutations, 52 could also be detected by Sanger sequencing resulting in a concordance of 98.4 % between the two sequencing methods. The three mutations missed by SGS had low variant frequencies below 10 %. Additionally, 4.8 % of the tumors had mutations in exons 1, 4, 7, and 13 of PIK3CA that were not detected by SGS. PIK3CA mutation status was significantly associated with hormone receptor-positivity, HER2-negativity, tumor grade, and lymph node involvement. However, there was no statistically significant association between the PIK3CA mutation status and overall survival. Based on our study, NGS is recommended as follows: 1) for correctly assessing the mutation status of PIK3CA in breast cancer, especially for cases with low tumor content, 2) for the detection of subclonal mutations, and 3) for simultaneous mutation detection in multiple exons.

  16. André Gide e o discurso imoralista

    OpenAIRE

    Betancur, Juan David González

    2016-01-01

    O presente artigo apresenta aspectos do discurso do autor francês André Gide em relação ao assunto da homossexualidade a partir de suas obras O imoralista, Corydon e O pombo torcaz, as quais foram ponto de partida para a criação de um espetáculo teatral. O criador do espetáculo localiza a obra de André Gide dentro de seu imaginário sobre a homossexualidade e, a partir dos materiais que lhe fornece esse discurso, descreve o que seria a imoralidade na proposta do francês.

  17. Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG Study.

    Directory of Open Access Journals (Sweden)

    George Papaxoinis

    Full Text Available The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9 and kinase (exon 20 domains of this protein. The aim of the present study was to examine the role of different types of PIK3CA mutations in combination with molecular biomarkers related to PI3K-AKT signaling in patients with early breast cancer.Tumor tissue samples from 1008 early breast cancer patients treated with adjuvant chemotherapy in two similar randomized trials of HeCOG were examined. Tumors were subtyped with immunohistochemistry (IHC and FISH for ER, PgR, Ki67, HER2 and androgen receptor (AR. PIK3CA mutations were analyzed by Sanger sequencing (exon 20 and qPCR (exon 9 (Sanger/qPCR mutations. In 610 cases, next generation sequencing (NGS PIK3CA mutation data were also available. PIK3CA mutations and PTEN protein expression (IHC were analyzed in luminal tumors (ER and/or PgR positive, molecular apocrine carcinomas (MAC; ER/PgR negative / AR positive and hormone receptor (ER/PgR/AR negative tumors.PIK3CA mutations were detected in 235/1008 tumors (23% with Sanger/qPCR and in 149/610 tumors (24% with NGS. Concordance between the two methods was good with a Kappa coefficient of 0.76 (95% CI 0.69-0.82. Lobular histology, low tumor grade and luminal A tumors were associated with helical domain mutations (PIK3CAhel, while luminal B with kinase domain mutations (PIK3CAkin. The overall incidence of PIK3CA mutations was higher in luminal as compared to MAC and hormone receptor negative tumors (p = 0.004. Disease-free and overall survival did not significantly differ with respect to PIK3CA mutation presence and type. However, a statistically significant interaction between PIK3CA mutation status and PTEN low protein expression with regard to prognosis was identified.The present study did not show any prognostic significance of specific PIK3CA mutations in a large group of predominantly lymph-node positive breast cancer

  18. {pi}K interaction effects on CP violation in B (right arrow) K {pi} {sup + }{pi}{ sup -} decays.

    Energy Technology Data Exchange (ETDEWEB)

    Loiseau, B.; El-Bennich, B.; Furman, A.; Kaminski, R.; Lesniak, L.; Moussallam, B.; Physics; LPNHE, Univ. Pierre et Marie Curie; The Henryk Niewodniczanski Inst. of Nucler Physics; IPN, CNRS/Univ. Paris; ul.Bronowicka 85/26

    2009-04-30

    The authors apply QCD factorization to the quasi two-body B {yields} (K{pi}){pi} decays where the (K{pi})-pair effective mass is limited to 1.8 GeV. Our strong interaction phases constrained by theory and {pi}K experimental data yield useful information for studies of CP violation.

  19. Parts harvendas ootamatult Eesti Energia nõukogu / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2011-01-01

    Majandus- ja kommunikatsiooniminister Juhan Parts otsustas 1. juulil päevapealt Eesti Energia nõukogu liikme kohalt tagasi kutsuda Aivar Reiviku ning Rein Kuusmiku, kes olid vastu Eesti Energia üle viie miljoni euro suurusele investeeringule Weroli rapsiõlitehase juurde rajatavasse elektri- ja küttejaama. Uuteks nõukogu liikmeteks said Andres Saame ja Toomas Tauts

  20. Peaosa nii teatrilaval kui ka kinolinal / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    Natalja Murina-Puustusmaast, kes mängib peaosa Vene Teatri uuslavastuses "Besame mucho", mille Afolf Käis on lavastanud Eduardo de Filippo näidendi "Silinder" järgi, ja Andres Puustusmaa filmis "Rotilõks", mille võtted algavad peagi

  1. Kino, Theater, Fernsehen : André Bazins Publikumstheorie

    NARCIS (Netherlands)

    Hanich, Julian; Mundhenke, Florian; Weber, Thomas

    2017-01-01

    What did the great French film theorist André Bazin think of the collective experience in the cinema? What did he write about the influence co-viewers can have on the emotional engagement, the evaluation and the interpretation of a film? In short: What was his audience theory? To be sure, Bazin is

  2. Andres Sütevaka näitus Stockholmis

    Index Scriptorium Estoniae

    2000-01-01

    Sütevaka Andrese abstraktsete maalide näitus Stockholmi Eesti Majas. Sütevaka Andres ja näituse avamisele sõitnud tema loomingu kollektsionäär Matti Milius kohtusid Moderna Museeti direktori David Elliotiga teadvustamaks Tartu ja Pärnu kunstielu.

  3. Mis siis juhtus Andres Lapeteusega? / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie

    2011-01-01

    Režissöör Grigori Kromanovi filmist "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1965). Osades: Einari Koppel, Ita Ever, Heino Mandri, Kaljo Kiisk, Uno Loit, Ada Lundver jt. Lühidalt filmi kohta ilmunud arvustustest. Filmi näeb ETV2-s sarjas "Unustatud filmid"

  4. Kommest Auto ostmisest huvitub ka Hillar Teder / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2008-01-01

    Kommest Auto ostmise vastu tunnevad huvi suurärimees Andres Sarri, Rootsis Peugeot' sõidukeid müüv Taani päritolu K. W. Bruun Import ja multimiljonär Hillar Teder, kellele kuulub Audisid müüv Reval Auto

  5. Mis on looming.org? : elektrooniline heli / Andres Lõo

    Index Scriptorium Estoniae

    Lõo, Andres

    2004-01-01

    Võrguajakirjast www.looming.org, kuhu kogutakse infot põhiliselt kahe jaotuse põhjal: muusika ja helieksperimentalism ning kaasaegne kunst, kunsti ja meediaga seonduv. Idee autorid: Hanno Soans ja Andres Lõo. Ilmunud on looming.orgi esimene muusikakogumik "Lilled algebrale"

  6. Andres Noormets : filmilik fantaasiateater lohe ja armastusega / Dea Martinjonis

    Index Scriptorium Estoniae

    Martinjonis, Dea

    1999-01-01

    "Meremaa võlur. Päeva kaldad", näidend Ursula K Le Guini "Meremaa võluri" teemadel, kirjutanud Andreas W ja lavastanud Andres Noormets, kunstnik Silver Vahtre, valguskunstnik Airi Eras, helikujundaja ja videograafik Andreas W. Esietendus Ugalas 29. aprillil

  7. EGFR gene copy number predicts response to anti-EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer.

    Science.gov (United States)

    Ålgars, Annika; Sundström, Jari; Lintunen, Minnamaija; Jokilehto, Terhi; Kytölä, Soili; Kaare, Milja; Vainionpää, Reetta; Orpana, Arto; Österlund, Pia; Ristimäki, Ari; Carpen, Olli; Ristamäki, Raija

    2017-02-15

    Anti-EGFR antibodies are used for the treatment of RAS wild type metastatic colorectal cancer. We previously showed that EGFR gene copy number (GCN) predicts response to anti-EGFR therapy in KRAS exon 2 wild type metastatic colorectal cancer. The aim of our study was to analyse the predictive role of EGFR GCN in RAS/BRAF/PIK3CA wild type metastatic colorectal cancer. The material included 102 patients with KRAS exon 2 wild type metastatic colorectal cancer treated with anti-EGFR ± cytotoxic therapy. Next generation sequencing was used for KRAS, NRAS, BRAF and PIK3CA gene mutation analyses. EGFR GCN was analysed by EGFR immunohistochemistry guided automated silver in situ hybridisation. Increased EGFR GCN (≥4.0) predicted a better response and prolonged progression free survival in anti-EGFR treated RAS/BRAF/PIK3CA wild type patients (Log-rank test, p = 0.0004). In contrast, survival of RAS/BRAF/PIK3CA wild type, EGFR GCN below 4.0 patients did not differ from patients with mutant RAS, BRAF or PIK3CA. Our study indicates that EGFR GCN predicts anti-EGFR treatment efficacy in patients with RAS/BRAF/PIK3CA wt metastatic CRC. Tumours with EGFR GCN below 4.0 appear to be as refractory to anti-EGFR treatment as tumours with mutation in any of the RAS/RAF/PIK3CA pathway genes. © 2016 UICC.

  8. High-density ultracold neutron sources for the WWR-M and PIK reactors

    Energy Technology Data Exchange (ETDEWEB)

    Serebrov, A. P., E-mail: serebrov@pnpi.spb.ru; Fomin, A. K.; Kharitonov, A. G.; Lyamkin, V. A.; Prudnikov, D. V.; Ivanov, S. A.; Erykalov, A. N.; Onegin, M. S. [National Research Centre “Kurchatov Institute”, Petersburg Nuclear Physics Institute (Russian Federation); Gridnev, K. A. [St. Petersburg State University (Russian Federation)

    2016-01-15

    It is proposed to equip the PIK and WWR-M research reactors at the Petersburg Nuclear Physics Institute (PNPI) with high-density ultracold neutron (UCN) sources, where UCNs will be obtained based on the effect of their accumulation in superfluid helium (due to the specific features of this quantum fluid). The maximum UCN storage time in superfluid helium is obtained at temperatures on the order of 1 K. These sources are expected to yield UCN densities of 10{sup 3}–10{sup 4} cm{sup –3}, i.e., approximately three orders of magnitude higher than the density from existing UCN sources throughout the world. The development of highest intensity UCN sources will make PNPI an international center of fundamental UCN research.

  9. Prognostic role of KRAS, NRAS, BRAF and PIK3CA mutations in advanced colorectal cancer.

    Science.gov (United States)

    Foltran, Luisa; De Maglio, Giovanna; Pella, Nicoletta; Ermacora, Paola; Aprile, Giuseppe; Masiero, Elena; Giovannoni, Mariella; Iaiza, Emiliana; Cardellino, Giovanni Gerardo; Lutrino, Stefania Eufemia; Mazzer, Micol; Giangreco, Manuela; Pisa, Federica Edith; Pizzolitto, Stefano; Fasola, Gianpiero

    2015-01-01

    To explore the prognostic value of extended mutational profiling for metastatic colorectal cancer (mCRC). We retrospectively reviewed survival results of 194 mCRC patients that were assigned to four molecular subgroups: BRAF mutated; KRAS mutated codons 12-13 only; any of KRAS codons 61-146, PIK3CA or NRAS mutations and all wild-type. Point mutations were investigated by pyrosequencing. BRAF (5.2%) and KRAS 12-13 (31.9%) mutations were associated with poorer survival (HR 2.8 and 1.76, respectively). Presenting with right-sided colon cancer, not resected primary tumor, WBC >10 × 10(9)/l, receiving less chemotherapy or no bevacizumab were all associated with inferior outcome. The all-wild-type subgroup (39.2%) reported the longest survival. Extended mutational profile combined with clinical factors may impact on survival in mCRC.

  10. Dual HER2\\PIK3CA targeting overcomes single-agent acquired resistance in HER2 amplified uterine serous carcinoma cell lines in vitro and in vivo

    Science.gov (United States)

    Lopez, Salvatore; Cocco, Emiliano; Black, Jonathan; Bellone, Stefania; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Schwab, Carlton L.; English, Diana P.; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E.; Terranova, Corrado; Angioli, Roberto; Santin, Alessandro D.

    2015-01-01

    HER2/neu gene amplification and PIK3CA driver mutations are common in uterine serous carcinoma (USC), and may represent ideal therapeutic targets against this aggressive variant of endometrial cancer. We examined the sensitivity to neratinib, taselisib and the combination of the two compounds in in vitro and in vivo experiments using PIK3CA mutated and PIK3CA-wild type HER2/neu amplified USC cell lines. Cell viability and cell cycle distribution were assessed using flow-cytometry assays. Downstream signaling was assessed by immunoblotting. Preclinical efficacy of single versus dual inhibition was evaluated in vivo using two USC-xenografts. We found both single agent neratinib and taselisib to be active but only transiently effective in controlling the in vivo growth of USC xenografts harboring HER2/neu gene amplification with or without oncogenic PIK3CA mutations. In contrast, the combination of the two inhibitors caused a stronger and long lasting growth inhibition in both USC xenografts when compared to single agent therapy. Combined targeting of HER2 and PIK3CA was associated with a significant and dose-dependent increase in the percentage of cells in the G0/G1 phase of the cell cycle and a dose-dependent decline in the phosphorylation of S6. Importantly, dual inhibition therapy initiated after tumor progression in single agent-treated mice was still remarkably effective at inducing tumor regression in both large PIK3CA or pan-ErbB inhibitor-resistant USC xenografts. Dual HER2/PIK3CA blockade may represent a novel therapeutic option for USC patients harboring tumors with HER2/neu gene amplification and mutated or wild type PIK3CA resistant to chemotherapy. PMID:26333383

  11. Mida teeks tulevane kultuuriminister 500 miljoni krooniga? / interv. Andres Keil

    Index Scriptorium Estoniae

    2007-01-01

    Suuremate erakondade kultuurispetsialistid (kultuuriministrikandidaadid) Urmas Paet, Andres Herkel, Peeter Jalakas, Indrek Saar, Jaak Allik, samuti kultuuriminister Raivo Palmaru vastavad küsimustele, mis on suurimad ohud eesti keele ja rahvuskultuuri säilimisele, milline on kultuuriministeeriumi ja -ministri portfelli staatus praeguses valitsuses, kas kultuuri rahastamine riigieelarvest on piisav, mille poolest erineb nende erakonna nägemus kultuuripoliitikast teiste erakondade omast, kuhu nad suunaksid 50, 500 miljonit, kui see oleks nende käsutuses

  12. Tallinna Lennujaama kauba- ja tolliterminaal. Lennujaama 2, Tallinn / Andres Põime

    Index Scriptorium Estoniae

    Põime, Andres

    1998-01-01

    Kaubateeninduskeskuse puhul on tegemist suure, plaanimõõtudes 36x102 meetrise metallkonstruktsioonis, sandwich tüüpi paneelidega kaetud laohoonega, kus ühelt poolt tuuakse tollitav kaup lennukitelt sisse ja teiselt poolt viiakse tollitud kaup välja. Peatöövõtja : Normanni Linnagrupi AS. Ehitaja : Merko. Peaprojekteerija : K-Projekt. Arhitektuurne lahendus : Stuudio 3. Arhitekt Andres Põime ; töögrupp Vivian Oruvee, Tiiu Raudsepp, Reet Põime. Projekt 1997-98, valmis 1998.

  13. Revolver, kala ja harmoonia / Andres Tolts ; intervjueerinud Kadri Karro

    Index Scriptorium Estoniae

    Tolts, Andres, 1949-2014

    2009-01-01

    Andres Toltsi juubelinäitused Tallinnas: "Näitus" Tallinna Kunstihoones 25.9-25.10, "Asjad" Hobusepea galeriis 30.9-12.10, "Juubelinäitus" Haus galeriis 8.10-13.11. Kunstnik räägib oma loomingust, revolvri ja kala motiivist oma töödes, mõttekaaslusest, eestiaegsest maailmavaatest, harmooniast ja isikupärast kunstis ning elus, ilust ja inetusest, kaasaja kunstnike vajadusest oma loomingut sõnade abil seletada

  14. Kutseharidust hakkab muutma uus paradigma / André Huigens ; intervjueerinud Veiko Belials

    Index Scriptorium Estoniae

    Huigens, André

    2011-01-01

    Intervjuu Luual toimunud rahvusvahelise kutsehariduse alase seminari peaesineja, André Huigensiga, kes on Euroopa kutseõppe arenduskeskuse Cedefop kvalifikatsiooniraamistiku ekspert Hollandi Wellantcollege’ist

  15. PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors.

    Science.gov (United States)

    Croessmann, Sarah; Sheehan, Jonathan H; Lee, Kyung-Min; Sliwoski, Gregory R; He, Jie; Nagy, Rebecca J; Riddle, David A; Mayer, Ingrid A; Balko, Justin M; Lanman, Richard B; Miller, Vincent; Cantley, Lewis C; Meiler, Jens; Arteaga, Carlos L

    2017-12-28

    We describe herein a novel P447_L455 deletion in the C2 domain of PIK3CA in a patient with an ER+ breast cancer with an excellent response to the PI3Kα inhibitor alpelisib. Although PIK3CA deletions are relatively rare, a significant portion of deletions cluster within amino acids 446-460 of the C2 domain, suggesting these residues are critical for p110α function.   Design: A computational structural model of PIK3CAdelP447-L455 in complex with the p85 regulatory subunit and MCF10A cells expressing PIK3CAdelP447-L455 and PIK3CAH450_P458del were used to understand the phenotype of C2 domain deletions.  Computational modeling revealed specific favorable inter-residue contacts that would be lost as a result of the deletion, predicting a significant decrease in binding energy. Co-immunoprecipitation experiments showed reduced binding of the C2 deletion mutants with p85 compared to wild type p110α. The MCF10A cells expressing PIK3CA C2 deletions exhibited growth factor-independent growth, an invasive phenotype, and higher phosphorylation of AKT, ERK and S6 compared to parental MCF10A cells. All these changes were ablated by alpelisib treatment. C2 domain deletions in PIK3CA generate PI3K dependence and should be considered biomarkers of sensitivity to PI3K inhibitors. Copyright ©2017, American Association for Cancer Research.

  16. Die pikareske tematiek in André P. Brink se Inteendeel | Cochrane ...

    African Journals Online (AJOL)

    The themes examined are disillusionment, freedom, hunger, loneliness and gullibility. Possible weaknesses in Wicks's theoretical overview will be identified, especially when tested against an individual text. Key Words: André Brink, Inteendeel (On the Contrary) , picaresque literature, picaro. Die pikareske tematiek in André ...

  17. André Brink: An aesthetics of response | Diala | Tydskrif vir letterkunde

    African Journals Online (AJOL)

    André Brink: An aesthetics of response [English] As a commentator on the enormities of the apartheid state, André Brink rose to international prominence during the struggle against apartheid in the 1970s and 1980s. In interviews, speeches and non-fictional writing, Brink\\'s enduring meditation on the writer\\'s responsibility ...

  18. Globaliseerumine : oht või võimalus? / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2007-01-01

    Globaliseerumise ja võrgustumise muutumine võimaluseks või ohuks sõltub konkreetse riigi majanduse ja tööturu kohanemisvõimest. Globaalsete finantsvoogude kirjeldus, kapitali ja Eestisse tulevate rahavoogude analüüs ning hinnang Eesti tööturu paindlikkusele ja ettevõtjate innovatiivsusele. Graafikud: Otse- ja portfelliinvesteeringute ning laenude sissevool Eestisse 1992-2006; Diagramm: Eesti tööjõuturg sammub Ameerika jälgedes. Vt. samas: Andres Saarniit. Raha ei ole kuhugi kadunud

  19. Unilateral vestibular schwannoma and meningiomas in a patient with PIK3CA-related segmental overgrowth: Co-occurrence of mosaicism for 2 rare disorders.

    Science.gov (United States)

    Mills, J R; Moyer, A M; Kipp, B R; Poplawski, A B; Messiaen, L M; Babovic-Vuksanovic, D

    2018-01-01

    A 28-year-old female with PIK3CA-related segmental overgrowth presented with headaches. She also had a unilateral vestibular schwannoma (VS), as well as 3 small (A (p.Gly914Arg) mutation, confirming the diagnosis of PIK3CA-related overgrowth, but no mutations in NF2 were detected. Although VS has not previously been reported in PIK3CA-related segmental overgrowth, meningiomas have, raising the question of whether this patient's VS and meningiomas represent coincidental NF2 or phenotypic extension of her overgrowth syndrome. Genetic analysis of the VS revealed a heterozygous NF2 mutation c.784C>T (p.Arg262Ter) and loss of a portion of 22q, including NF2, SMARCB1, and LZTR1 genes. These results suggest that the patient has 2 different mosaic disorders, NF2 and PIK3CA-related overgrowth. The PIK3CA mutation was also present in the VS. Confirmation of the clinical diagnosis of mosaic NF2 in this patient has implications for monitoring and highlights the possibility of co-occurrence of mosaicism for multiple rare disorders in a single patient. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Pomeranchuk Prize awarded to André Martin

    CERN Multimedia

    Jordan Juras

    2010-01-01

    Professor André Martin has been awarded the I.Ya.Pomeranchuk Prize 2010, alongside Professor Valentine Zakharov.   André Martin, CERN theorist, pictured at the ceremony held in honour of his 80th birthday (August 2009). Established by the Institute of Theoretical and Experimental Physics (ITEP) in memory of an outstanding scientist Isaak Yakovlevich Pomeranchuk, the prize is awarded for the study of analytic properties of the scattering amplitude; which lead to the Froissart—Martin bound on the cross section growth with energy. The prize comes as a great honor for Martin, who was in fact a good friend of Mr. Pomeranchuk, "I am surprised and delighted to learn that I will be receiving the 2010 Pomeranchuk Prize. I was an admirer of Pomeranchuk and we shared a great friendship. I met with him for the last time in Erevan (Armenia) in 1965. As a good-bye, he told me, 'Analyticity exists'. This is precisely what I proved to earn the prize"....

  1. Analytical complex at the PIK reactor for studying the supra-atomic structure and dynamics of materials by neutron scattering

    Energy Technology Data Exchange (ETDEWEB)

    Lebedev, V. M., E-mail: lebedev@pnpi.spb.ru; Lebedev, V. T.; Ivanova, I. N.; Orlova, D. N. [Russian Academy of Sciences, St. Petersburg Nuclear Physics Institute (Russian Federation)

    2011-12-15

    A project of the center for studying reactor materials and solving problems of materials science is presented which will be equipped with the following neutron instruments: a small-angle Membrana diffractometer, a spin-echo spectrometer, and a time-of-flight spectrometer. It is proposed to irradiate materials in the PIK reactor core and use neutron-scattering tools to analyze the structure and dynamics of these materials and investigate radiative defects in the complete experimental cycle (initial material-irradiation-strength tests, thermal loads, and other effects) using materials science techniques.

  2. Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia.

    Science.gov (United States)

    Palomba, Grazia; Colombino, Maria; Contu, Antonio; Massidda, Bruno; Baldino, Giovanni; Pazzola, Antonio; Ionta, MariaTeresa; Capelli, Francesca; Trova, Vittorio; Sedda, Tito; Sanna, Giovanni; Tanda, Francesco; Budroni, Mario; Palmieri, Giuseppe; Cossu, Antonio; Contu, Marta; Cuccu, Angelo; Farris, Antonio; Macciò, Antonio; Mameli, Giuseppe; Olmeo, Nina; Ortu, Salvatore; Petretto, Elisabetta; Pusceddu, Valeria; Virdis, Luciano

    2012-08-29

    Role of KRAS, BRAF and PIK3CA mutations in pathogenesis of colorectal cancer (CRC) has been recently investigated worldwide. In this population-based study, we evaluated the incidence rates and distribution of such somatic mutations in genetically isolated population from Sardinia. From April 2009 to July 2011, formalin-fixed paraffin-embedded tissues (N = 478) were prospectively collected from Sardinian CRC patients at clinics across the entire island. Genomic DNA was isolated from tissue sections and screened for mutations in KRAS, BRAF, and PIK3CA genes by automated DNA sequencing. Overall, KRAS tumour mutation rate was 30% (145/478 positive cases). Distribution of mutation carriers was surprisingly different within the island: 87/204 (43%) in North Sardinia vs. 58/274 (21%) in Middle-South Sardinia (p<0.001). Among 384 CRC cases whose DNA was available, only one (0.3%) patient carried a mutation in BRAF gene; PIK3CA was found mutated in 67 (17%) patients. A significant inverse distribution of PIK3CA mutation rates was observed within Sardinian population: 19/183 (10%) cases from northern vs. 48/201 (24%) cases from central-southern island (p<0.001). This heterogeneity in frequencies of KRAS/PIK3CA somatic mutations is consistent with already-reported discrepancies in distribution of germline mutations for other malignancies within Sardinian population. Preliminary clinical evaluation of 118 KRAS wild-type patients undergoing anti-EGFR-based treatment indicated lack of role for PIK3CA in predicting response to therapy. Our findings support the hypothesis that differences in patients' origins and related genetic backgrounds may contribute to even determine the incidence rate of somatic mutations in candidate cancer genes.

  3. Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia

    Directory of Open Access Journals (Sweden)

    Palomba Grazia

    2012-08-01

    Full Text Available Abstract Background Role of KRAS, BRAF and PIK3CA mutations in pathogenesis of colorectal cancer (CRC has been recently investigated worldwide. In this population-based study, we evaluated the incidence rates and distribution of such somatic mutations in genetically isolated population from Sardinia. Methods From April 2009 to July 2011, formalin-fixed paraffin-embedded tissues (N = 478 were prospectively collected from Sardinian CRC patients at clinics across the entire island. Genomic DNA was isolated from tissue sections and screened for mutations in KRAS, BRAF, and PIK3CA genes by automated DNA sequencing. Results Overall, KRAS tumour mutation rate was 30% (145/478 positive cases. Distribution of mutation carriers was surprisingly different within the island: 87/204 (43% in North Sardinia vs. 58/274 (21% in Middle-South Sardinia (pBRAF gene; PIK3CA was found mutated in 67 (17% patients. A significant inverse distribution of PIK3CA mutation rates was observed within Sardinian population: 19/183 (10% cases from northern vs. 48/201 (24% cases from central-southern island (pKRAS/PIK3CA somatic mutations is consistent with already-reported discrepancies in distribution of germline mutations for other malignancies within Sardinian population. Preliminary clinical evaluation of 118 KRAS wild-type patients undergoing anti-EGFR-based treatment indicated lack of role for PIK3CA in predicting response to therapy. Conclusions Our findings support the hypothesis that differences in patients’ origins and related genetic backgrounds may contribute to even determine the incidence rate of somatic mutations in candidate cancer genes.

  4. Molecular and Functional Characterization of Three Different Postzygotic Mutations in PIK3CA-Related Overgrowth Spectrum (PROS Patients: Effects on PI3K/AKT/mTOR Signaling and Sensitivity to PIK3 Inhibitors.

    Directory of Open Access Journals (Sweden)

    Daria C Loconte

    Full Text Available PIK3CA-related overgrowth spectrum (PROS include a group of disorders that affect only the terminal portion of a limb, such as type I macrodactyly, and conditions like fibroadipose overgrowth (FAO, megalencephaly-capillary malformation (MCAP syndrome, congenital lipomatous asymmetric overgrowth of the trunk, lymphatic, capillary, venous, and combined-type vascular malformations, epidermal nevi, skeletal and spinal anomalies (CLOVES syndrome and Hemihyperplasia Multiple Lipomatosis (HHML. Heterozygous postzygotic PIK3CA mutations are frequently identified in these syndromes, while timing and tissue specificity of the mutational event are likely responsible for the extreme phenotypic variability observed.We carried out a combination of Sanger sequencing and targeted deep sequencing of genes involved in the PI3K/AKT/mTOR pathway in three patients (1 MCAP and 2 FAO to identify causative mutations, and performed immunoblot analyses to assay the phosphorylation status of AKT and P70S6K in affected dermal fibroblasts. In addition, we evaluated their ability to grow in the absence of serum and their response to the PI3K inhibitors wortmannin and LY294002 in vitro.Our data indicate that patients' cells showed constitutive activation of the PI3K/Akt pathway. Of note, PI3K pharmacological blockade resulted in a significant reduction of the proliferation rate in culture, suggesting that inhibition of PI3K might prove beneficial in future therapies for PROS patients.

  5. Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin

    Science.gov (United States)

    Cufí, Sílvia; Corominas-Faja, Bruna; Lopez-Bonet, Eugeni; Bonavia, Rosa; Pernas, Sonia; López, Isabel álvarez; Dorca, Joan; Martínez, Susana; López, Norberto Batista; Fernández, Severina Domínguez; Cuyàs, Elisabet; Visa, Joana; Rodríguez-Gallego, Esther; Quirantes-Piné, Rosa; Segura-Carretero, Antonio; Joven, Jorge; Martin-Castillo, Begoña; Menendez, Javier A.

    2013-01-01

    Cancer cells expressing constitutively active phosphatidylinositol-3 kinase (PI3K) are proliferative regardless of the absence of insulin, and they form dietary restriction (DR)-resistant tumors in vivo. Because the binding of insulin to its receptors activates the PI3K/AKT/mammalian target of rapamycin (mTOR) signaling cascade, activating mutations in the PIK3CA oncogene may determine tumor response to DR-like pharmacological strategies targeting the insulin and mTOR pathways. The anti-diabetic drug metformin is a stereotypical DR mimetic that exerts its anti-cancer activity through a dual mechanism involving insulin-related (systemic) and mTOR-related (cell-autonomous) effects. However, it remains unclear whether PIK3CA-activating mutations might preclude the anti-cancer activity of metformin in vivo. To model the oncogenic PIK3CA-driven early stages of cancer, we used the clonal breast cancer cell line MCF10DCIS.com, which harbors the gain-of-function H1047R hot-spot mutation in the catalytic domain of the PI3KCA gene and has been shown to form DR-refractory xenotumors. To model PIK3CA-activating mutations in late stages of cancer, we took advantage of the isogenic conversion of a PIK3CA-wild-type tumor into a PIK3CA H1047R-mutated tumor using the highly metastatic colorectal cancer cell line SW48. MCF10DCIS.com xenotumors, although only modestly affected by treatment with oral metformin (approximately 40% tumor growth inhibition), were highly sensitive to the intraperitoneal (i.p.) administration of metformin, the anti-cancer activity of which increased in a time-dependent manner and reached >80% tumor growth inhibition by the end of the treatment. Metformin treatment via the i.p. route significantly reduced the proliferation factor mitotic activity index (MAI) and decreased tumor cellularity in MCF10DCIS.com cancer tissues. Whereas SW48-wild-type (PIK3CA+/+) cells rapidly formed metformin-refractory xenotumors in mice, ad libitum access to water containing

  6. Pierre Darriulat is awarded the André Lagarrigue Prize

    CERN Multimedia

    2009-01-01

    Pierre Darriulat at the VATLY Laboratory in Hanoï. Former CERN Research Director, Pierre Darriulat, who is now Professor of Physics at VATLY in Hanoi (Vietnam), has won the 2008 André Lagarrigue Prize. This prize, instituted by the Linear Accelerator Laboratory (LAL) at Orsay under the aegis of the French Physical Society, is awarded to front-line researchers who have had responsibility for machine/detector construction and derived maximum scientific benefit from such projects, performed in a French laboratory or in close collaboration with French groups. Pierre Darriulat has received the award in recognition of his outstanding career at the CEA, at LBL (Berkeley) and at CERN from 1964 onwards. At CERN he managed the experiments at the Intersecting Storage Rings (ISR) before taking charge of the UA2 collaboration from 1980 to 1986, which participated in decisive discoveries at the ppbar collider. In particular, in 1982, the UA2 experiment began observing high trans...

  7. Neurology and surrealism: André Breton and Joseph Babinski.

    Science.gov (United States)

    Haan, Joost; Koehler, Peter J; Bogousslavsky, Julien

    2012-12-01

    Before he became the initiator of the surrealist movement, André Breton (1896-1966) studied medicine and worked as a student in several hospitals and as a stretcher bearer at the front during World War I. There he became interested in psychiatric diseases such as hysteria and psychosis, which later served as a source of inspiration for his surrealist writings and thoughts, in particular on automatic writing. Breton worked under Joseph Babinski at La Pitié, nearby La Salpêtrière, and became impressed by the 'sacred fever' of the famous neurologist. In this article, we describe the relationship between Breton and Babinski and try to trace back whether not only Breton's psychiatric, but also his neurological experiences, have influenced surrealism. We hypothesize that Breton left medicine in 1920 partly as a consequence of his stay with Babinski.

  8. André-Louis Cholesky mathematician, topographer and army officer

    CERN Document Server

    Brezinski, Claude

    2014-01-01

    Outside the professional circles of topography and applied mathematics, the life and work of André-Louis Cholesky (1875–1918) are still relatively unknown to the scientific community. This new book appreciably widens the exposure of his remarkable personal achievements in topography and mathematics to a much larger international audience.   Cholesky is also interesting to historians because he is a perfect representative of the "scientists engineers" that, since the early 19th century, had issued from the French scientific high schools. Because they had received a high level of mathematical education, they were able to innovate in their practice of engineering. In the case of Cholesky, this resulted in original contributions in artillery, topography, numerical analysis and graphical calculation. In addition, the book places his education and works within the history of several European countries through the 17th to 19th centuries.   The book begins with Cholesky's biography, followed by his family’s hi...

  9. Läänemere strateegia arvestab kodanike ettepanekutega / Jose Palma Andres ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Palma Andres, Jose

    2008-01-01

    Euroopa Komisjoni regionaalpoliitika peadirektoraadi direktor Jose Palma Andres vastab küsimustele, mis puudutavad avalikku debatti Läänemere strateegia üle ning Venemaa partnerlust Läänemere strateegias. Lisa: [Läänemere strateegia

  10. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva

    2006-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  11. Tallinna idee / Andres Alver, Ott Alver, Marten Kaevats ; intervjueerinud Margit Mutso ; kommenteerinud Douglas Gordon

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2011-01-01

    17. veebruaril esitleti raamatut "Tallinna idee", mis on koostatud Eesti Kunstiakadeemia 4. kursuse arhitektuuritudengite kursuseprojektide põhjal. Tallinna teemal vestlevad tudengid Ott Alver ja Marten Kaevats ning nende juhendaja professor Andres Alver

  12. Põlvas tuli esitusele Andre Laine 29 tantsu / Mati Määrits

    Index Scriptorium Estoniae

    Määrits, Mati, 1958-

    2008-01-01

    Põlva Kultuuri- ja Huvikeskuses sai näha Põlvamaa Koolitantsu maakondlikku eelvooru. 52st tantsust 29 tantsu autor on Andre Laine. Kommenteerib ka Tartu Ülikooli Viljandi Kultuuriakadeemia lavakunstide osakonna tantsukunsti õppejõud Kai Valtna

  13. Eestlane juhib Ukrainas EBRD investeeringuid / Andre Küüsvek ; interv. Henrik Ilves

    Index Scriptorium Estoniae

    Küüsvek, Andre

    2008-01-01

    Seni Euroopa Rekonstruktsiooni- ja Arengupanga (EBRD) Kasahstani osakonda juhtinud Andre Küüsvek valiti juhtima EBRD investeeringuid Ukrainas. Tänavu on plaanis investeerida Ukrainas 1,5 mld. dollarit

  14. André-Philip Lemke näitus Tallinnas / Mari Laaniste

    Index Scriptorium Estoniae

    Laaniste, Mari, 1977-

    1998-01-01

    Saksa kunstniku André-Philip Lemke (1970) näitus "Üks-üks armsa Jumala kasuks" 17. augustist Saksa Kultuuriinstituudis. Tööd on valgele paberile tavalise sinise pastapliiatsiga kirjutatud-joonistatud

  15. Korterelamu Tallinnas Weizenbergi 29 = Apartment Building in Tallinn, at 29 Weizenbergi Street / Andres Alver

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2001-01-01

    Puitvoodriga betoonist kastjas hoone. Projekteerija Alver Trummal Arhitektid. Arhitektid Andres Alver ja Tarmo Laht. Eriosad: Eesti Projekt. Projekt 1998, valmis 2000. 3 ill.: põhiplaan, välisvaade, Pille Lausmäe kujundatud korteri vaade

  16. Haapsalu Gümnaasiumi võimla = Haapsalu Gymnasium Gym / Andres Alver

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2001-01-01

    Projekteerija: Alver Trummal Arhitektid OÜ. Arhitektid Andres Alver, Sven Koppel, Tarmo Laht, Ulla Mets. Projekt 1998-1999, hoone valmis 2001. 11 ill.: asendi- ja korruse plaan, pikilõige, välis- ja sisevaated

  17. Noblessneri Loomemaja = Noblessner Creative house / Rasmus Tamme, Jaanus Saarepera, Eero Jürgenson, Andres Jomp

    Index Scriptorium Estoniae

    2015-01-01

    Noblessneri Loomemaja Tallinnas Tööstuse 48/Peetri 11, valminud 2014. Arhitektid Rasmus Tamme, Jaanus Saarepera (ARS Projekt), sisearhitektid Eero Jürgenson, Andres Jomp (ARS Projekt). 2014. aasta Kultuurkapitali Arhitektuuripreemia kandidaat

  18. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva, 1980-

    2011-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  19. Raio Piiroja : mängijatest ei suudetud maksimumi pigistada / Andres Kalvik

    Index Scriptorium Estoniae

    Kalvik, Andres, 1982-

    2007-01-01

    Vt. ka Postimees : na russkom jazõke 19. nov., lk. 13. Eesti koondis võlgneb EM-valikturniiri viimase kohtumise 2:0 Andorra üle suuresti Andres Operile. Kommenteerib Andorra koondise peatreener David Rodrigo

  20. Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA (H1047R) in HER2/ER-positive breast cancer.

    Science.gov (United States)

    Cheng, Feixiong; Zhao, Junfei; Hanker, Ariella B; Brewer, Monica Red; Arteaga, Carlos L; Zhao, Zhongming

    2016-12-01

    Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in human breast cancer. Furthermore, PIK3CA mutations are commonly associated with resistance to anti-epidermal growth factor receptor 2 (HER2) or anti-estrogen receptor (ER) agents in HER2 or ER positive (HER2(+)/ER(+)) breast cancer. Hence, deciphering the underlying mechanisms of PIK3CA mutations in HER2(+)/ER(+) breast cancer would provide novel insights into elucidating resistance to anti-HER2/ER therapies. In this study, we systematically investigated the biological consequences of PIK3CA (H1047R) in HER2(+)/ER(+) breast cancer by uniquely incorporating mRNA transcriptomic data from The Cancer Genome Atlas and proteomic data from reverse-phase protein arrays. Our integrative bioinformatics analyses revealed that several important pathways such as STAT3 and VEGF/hypoxia were selectively altered by PIK3CA (H1047R) in HER2(+)/ER(+) breast cancer. Protein differential expression analysis indicated that an elevated eIF4G might promote tumor angiogenesis and growth via regulation of the hypoxia-activated switch in HER2(+) PIK3CA (H1047R) breast cancer. We observed hypo-phosphorylation of EGFR in HER2(+) PIK3CA (H1047R) breast cancer versus HER2(+)PIK3CA(wild-type) (PIK3CA (WT)). In addition, ER and PIK3CA (H1047R) might cooperate to activate STAT3, MAPK, AKT, and Hippo pathways in ER(+) PIK3CA (H1047R) breast cancer. A higher YAPpS127 level was observed in ER(+) PIK3CA (H1047R) patients than that in an ER(+) PIK3CA (WT) subgroup. By examining breast cancer cell lines having both microarray gene expression and drug treatment data from the Genomics of Drug Sensitivity in Cancer and the Stand Up to Cancer datasets, we found that the elevated YAP1 mRNA expression was associated with the resistance of BCL-2 family inhibitors, but with the sensitivity to MEK/MAPK inhibitors in breast cancer cells. In summary, these findings shed light on the functional consequences of PIK3CA (H1047R)-driven breast

  1. Mutational analysis of PIK3CA, JAK2, BRAF, FOXL2, IDH1, AKT1 and EZH2 oncogenes in sarcomas.

    Science.gov (United States)

    Je, Eun M; An, Chang H; Yoo, Nam J; Lee, Sug H

    2012-08-01

    Recent studies have revealed several recurrent mutations in oncogenes that could not only be underlying mechanisms of tumorigenesis, but also be potential targets for cancer therapies. Compared to carcinomas, genetic alterations of sarcomas are relatively unknown. To see whether recurrent oncogenes discovered in non-sarcomatous malignancies are present in sarcomas as well, we analyzed oncogenes with known mutations in various types of sarcomas. We performed mutational analysis of recurrent mutation sites of PIK3CA (exons 9 and 20), JAK2 (exon 14), BRAF (exon 15), FOXL2 (exon 1), IDH1 (exon 4), AKT1 (exon 3), and EZH2 (exon 16) genes in 108 sarcomas by single- strand conformation polymorphism and DNA sequencing. The sarcomas consisted of malignant fibrous histiocytomas, rhabdomyosarcomas, osteosarcomas, malignant peripheral nerve sheath tumors, leiomyosarcomas, synovial sarcomas, liposarcomas, angiosarcomas, chondrosarcomas, and Ewing sarcomas. Overall, we detected the two PIK3CA mutations and one JAK2 mutation (total: 3/108: 2.8%). Two rhabdomyosarcomas (16.7%) and one angiosarcoma (16.7%) harbored the mutations, whereas other sarcomas harbored none. The PIK3CA mutations were novel missense mutations that had not been detected in other cancers. The JAK2 mutation was an intron mutation. This study demonstrated that the somatic mutations of PIK3CA and JAK2 occurred in a small fraction of the sarcomas and that these mutations may not play a principal role in the development of sarcomas. © 2012 The Authors APMIS © 2012 APMIS.

  2. PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer

    NARCIS (Netherlands)

    Majewski, Ian J; Nuciforo, Paolo; Mittempergher, Lorenza; Bosma, Astrid J; Eidtmann, Holger; Holmes, Eileen; Sotiriou, Christos; Fumagalli, Debora; Jimenez, Jose; Aura, Claudia; Prudkin, Ludmila; Díaz-Delgado, Maria Carmen; de la Peña, Lorena; Loi, Sherene; Ellis, Catherine; Schultz, Nikolaus; de Azambuja, Evandro; Harbeck, Nadia; Piccart-Gebhart, Martine; Bernards, René|info:eu-repo/dai/nl/070416990; Baselga, José

    2015-01-01

    PURPOSE: We investigated whether mutations in the gene encoding the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) correlates with response to neoadjuvant human epidermal growth factor receptor 2 (HER2) -targeted therapies in patients with breast cancer. PATIENTS AND METHODS:

  3. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

    Directory of Open Access Journals (Sweden)

    Schmitt Fernando

    2008-09-01

    Full Text Available Abstract Background BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC. In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP, MLH1 methylation and microsatellite instability (MSI. We aimed at determine the frequency of KRAS, BRAF and PIK3CA mutations in the process of colorectal tumourigenesis using a series of colorectal polyps and carcinomas. In the series of polyps CIMP, MLH1 methylation and MSI were also studied. Methods Mutation analyses were performed by PCR/sequencing. Bisulfite treated DNA was used to study CIMP and MLH1 methylation. MSI was detected by pentaplex PCR and Genescan analysis of quasimonomorphic mononucleotide repeats. Chi Square test and Fisher's Exact test were used to perform association studies. Results KRAS, PIK3CA or BRAF occur in 71% of polyps and were mutually exclusive. KRAS mutations occur in 35% of polyps. PIK3CA was found in one of the polyps. V600E BRAF mutations occur in 29% of cases, all of them classified as serrated adenoma. CIMP phenotype occurred in 25% of the polyps and all were mutated for BRAF. MLH1 methylation was not detected and all the polyps were microsatellite stable. The comparison between the frequency of oncogenic mutations in polyps and CRC (MSI and MSS lead us to demonstrate that KRAS and PIK3CA are likely to precede both types of CRC. BRAF mutations are likely to precede MSI carcinomas since the frequency found in serrated polyps is similar to what is found in MSI CRC (P = 0.9112, but statistically different from what is found in microsatellite stable (MSS tumours (P = 0.0191. Conclusion Our results show that BRAF, KRAS and PIK3CA mutations occur prior to malignant transformation demonstrating that these oncogenic alterations are primary genetic events in colorectal carcinogenesis. Further, we show that BRAF mutations occur in association with CIMP phenotype in colorectal

  4. Relative quantification of PIK3CA gene expression level in fine-needle aspiration biopsy thyroid specimens collected from patients with papillary thyroid carcinoma and non-toxic goitre by real-time RT-PCR

    Directory of Open Access Journals (Sweden)

    Wojciechowska-Durczyńska Katarzyna

    2010-08-01

    Full Text Available Abstract Background Recent studies have shown that the phosphatidylinositol 3-kinase (PI3K signaling pathway is important regulator of many cellular events, including apoptosis, proliferation and motility. PI3K pathway alterations (PIK3CA gene mutations and/or amplification have been observed in various human tumours. In the majority of diagnosed cases, mutations are localized in one of the three "hot spots" in the gene, responsible for coding catalytic subunit α of class I PI3K (PIK3CA. Mutations and amplification of PIK3CA gene are characteristic for thyroid cancer, as well. Methods The aim of our study was to examine a gene expression level of PIK3CA in fine-needle aspiration biopsy (FNAB thyroid specimens in two types of thyroid lesions, papillary thyroid carcinoma (PTC and non-toxic goitre (NTG. Following conventional cytological examination, 42 thyroid FNAB specimens, received from patients with PTC (n = 20 and NTG (n = 22, were quantitatively evaluated regarding PIK3CA expression level by real-time PCR in the ABI PRISM® 7500 Sequence Detection System. Results Significantly higher expression level (RQ of PIK3CA in PTC group has been noted in comparison with NTG group (p Conclusion These observations may suggest role of PIK3CA alterations in PTC carcinogenesis.

  5. Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

    Directory of Open Access Journals (Sweden)

    Mitrou Panagiota N

    2011-04-01

    Full Text Available Abstract Background The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancers (CRC and their associations with tumour clinicopathological features, lifestyle factors and dietary consumptions. Methods 186 adenocarcinomas and 16 adenomas from the EPIC Norfolk study were tested for PTEN and PIK3CA mutations by DNA sequencing and PTEN expression changes by immunohistochemistry. Dietary and lifestyle data were collected prospectively using seven day food diaries and lifestyle questionnaires. Results Mutations in exons 7 and 8 of PTEN were observed in 2.2% of CRC and PTEN loss of expression was identified in 34.9% CRC. Negative PTEN expression was associated with lower blood low-density lipoprotein concentrations (p = 0.05. PIK3CA mutations were observed in 7% of cancers and were more frequent in CRCs in females (p = 0.04. Analysis of dietary intakes demonstrated no link between PTEN expression status and any specific dietary factor. PTEN expression negative, proximal CRC were of more advanced Dukes' stage (p = 0.02 and poor differentiation (p PIK3CA mutations and loss of PTEN expression demonstrated that these two events were independent (p = 0.55. Conclusion These data demonstrated the frequent occurrence (34.9% of PTEN loss of expression in colorectal cancers, for which gene mutations do not appear to be the main cause. Furthermore, dietary factors are not associated with loss of PTEN expression. PTEN expression negative CRC were not homogenous, as proximal cancers were associated with a more advanced Dukes' stage and poor differentiation, whereas distal cancers were associated with earlier Dukes' stage.

  6. PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation.

    Science.gov (United States)

    Silva, Jillian M; Deuker, Marian M; Baguley, Bruce C; McMahon, Martin

    2017-05-01

    Malignant conversion of BRAF- or NRAS-mutated melanocytes into melanoma cells can be promoted by PI3'-lipid signaling. However, the mechanism by which PI3'-lipid signaling cooperates with mutationally activated BRAF or NRAS has not been adequately explored. Using human NRAS- or BRAF-mutated melanoma cells that co-express mutationally activated PIK3CA, we explored the contribution of PI3'-lipid signaling to cell proliferation. Despite mutational activation of PIK3CA, melanoma cells were more sensitive to the biochemical and antiproliferative effects of broader spectrum PI3K inhibitors than to an α-selective PI3K inhibitor. Combined pharmacological inhibition of MEK1/2 and PI3K signaling elicited more potent antiproliferative effects and greater inhibition of the cell division cycle compared to single-agent inhibition of either pathway alone. Analysis of signaling downstream of MEK1/2 or PI3K revealed that these pathways cooperate to regulate cell proliferation through mTORC1-mediated effects on ribosomal protein S6 and 4E-BP1 phosphorylation in an AKT-dependent manner. Although PI3K inhibition resulted in cytostatic effects on xenografted NRASQ61H /PIK3CAH1047R melanoma, combined inhibition of MEK1/2 plus PI3K elicited significant melanoma regression. This study provides insights as to how mutationally activated PIK3CA acts in concert with MEK1/2 signaling to cooperatively regulate mTORC1/2 to sustain PIK3CA-mutated melanoma proliferation. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Ernst Julius Öpik's (1916) note on the theory of explosion cratering on the Moon's surface—The complex case of a long-overlooked benchmark paper

    Science.gov (United States)

    Racki, Grzegorz; Koeberl, Christian; Viik, Tõnu; Jagt-Yazykova, Elena A.; Jagt, John W. M.

    2014-10-01

    High-velocity impact as a common phenomenon in planetary evolution was ignored until well into the twentieth century, mostly because of inadequate understanding of cratering processes. An eight-page note, published in Russian by the young Ernst Julius Öpik, a great Estonian astronomer, was among the key selenological papers, but due to the language barrier, it was barely known and mostly incorrectly cited. This particular paper is here intended to serve as an explanatory supplement to an English translation of Öpik's article, but also to document an early stage in our understanding of cratering. First, we outline the historical-biographical background of this benchmark paper, and second, a comprehensive discussion of its merits is presented, from past and present perspectives alike. In his theoretical research, Öpik analyzed the explosive formation of craters numerically, albeit in a very simple way. For the first time, he approximated relationships among minimal meteorite size, impact energy, and crater diameter; this scaling focused solely on the gravitational energy of excavating the crater (a "useful" working approach). This initial physical model, with a rational mechanical basis, was developed in a series of papers up to 1961. Öpik should certainly be viewed as the founder of the numerical simulation approach in planetary sciences. In addition, the present note also briefly describes Nikolai A. Morozov as a remarkable man, a forgotten Russian scientist and, surprisingly, the true initiator of Öpik's explosive impact theory. In fact, already between 1909 and 1911, Morozov probably was the first to consider conclusively that explosion craters would be circular, bowl-shaped depressions even when formed under different impact angles.

  8. Alkohol, andre rusmidler og vold i epidemiologisk perspektiv

    Directory of Open Access Journals (Sweden)

    Kai Pernanen

    2009-10-01

    Full Text Available  SAMMENDRAGDen medisinske interessen for vold og voldsskader har økt kraftig i løpet av de siste to tiårene. Det epidemiologiskeperspektivet på vold har blitt forsterket og et mer etiologisk og preventivt syn på volden er mere merkbarinnenfor sosialmedisinsk forskning. Alkoholen er en etiologisk faktor som har vist seg å være forbundet med voldi de aller fleste samfunn. I denne artikkelen beskrives de viktigste epidemiologiske metodene og funnene i studietav alkoholens sammenheng med vold. Denne sammenhengen har vist seg ikke å være direkte, men er avhengig aven rekke andre faktorer, og noen forskjellige typer av kausal avhengighet beskrives i artikkelen. Den epidemiologiskeforskningen om andre rusmidlers sammenheng med vold er betydelig mindre omfattende enn den er foralkohol. Det er også åpenbart at andre rusmidler ikke er like sterkt sammenknyttet med vold som alkoholen.Pernanen K. Alcohol, other drugs, and violence in an epidemiological perspective.Nor J Epidemiol ENGLISH SUMMARYThe public health approach to violence has become increasingly accepted during the last couple of decades. Thishas led to more epidemiological research into violence, and a stronger medical interest in the etiology and preventionof violence. However, epidemiological research on the prevalence of violence in different societies is stillmainly criminological in nature, being based on information about violence that has come to the attention of thepolice or processed in the courts. The study of the relationship between alcohol use and violent behaviour is alsopredominantly based on police and court materials, although an increasing number of emergency room andhospitalization studies have examined the role of alcohol in injuries caused by violence.There are two basic methodological approaches in the study of the relationship between alcohol use andviolence. The alcohol-involvement studies estimate the extent to which drinking by the offender or the victim

  9. Kultuuriaasta väljapaistvamaks sündmuseks osutus kirjandusfestival / Ilona Smushkina, Tiia Toomet, Andres Keil ; interv. [Raimu Hanson

    Index Scriptorium Estoniae

    Smushkina, Ilona

    2005-01-01

    Tartu Kultuurikandjad - "Aasta kultuurikandja" : kirjandusfestival "Prima Vista" (festivali juhatuse liige Ilona Smushkina), kultuurikajastaja Andres Keil, kutseline kooslus - Tartu Mänguasja muuseum (direktor Tiia Toomet) jt.

  10. Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant

    Science.gov (United States)

    Pavlaki, Maria; Lazani, Vasiliki; Christoforidis, Savvas; Agianian, Bogos; Cournia, Zoe

    2014-01-01

    The PIK3CA gene is one of the most frequently mutated oncogenes in human cancers. It encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα), which activates signaling cascades leading to cell proliferation, survival, and cell growth. The most frequent mutation in PIK3CA is H1047R, which results in enzymatic overactivation. Understanding how the H1047R mutation causes the enhanced activity of the protein in atomic detail is central to developing mutant-specific therapeutics for cancer. To this end, Surface Plasmon Resonance (SPR) experiments and Molecular Dynamics (MD) simulations were carried out for both wild-type (WT) and H1047R mutant proteins. An expanded positive charge distribution on the membrane binding regions of the mutant with respect to the WT protein is observed through MD simulations, which justifies the increased ability of the mutated protein variant to bind to membranes rich in anionic lipids in our SPR experiments. Our results further support an auto-inhibitory role of the C-terminal tail in the WT protein, which is abolished in the mutant protein due to loss of crucial intermolecular interactions. Moreover, Functional Mode Analysis reveals that the H1047R mutation alters the twisting motion of the N-lobe of the kinase domain with respect to the C-lobe and shifts the position of the conserved P-loop residues in the vicinity of the active site. These findings demonstrate the dynamical and structural differences of the two proteins in atomic detail and propose a mechanism of overactivation for the mutant protein. The results may be further utilized for the design of mutant-specific PI3Kα inhibitors that exploit the altered mutant conformation. PMID:25340423

  11. Andres Puustusmaa - mees nagu jalgratas ehk Seitseteist kevadist hetke enne Moskva rongi väljumist / Andres Puustusmaa ; interv. Margus Mikomägi

    Index Scriptorium Estoniae

    Puustusmaa, Andres

    2008-01-01

    Venemaal tegutseva Eestist pärit režissööri Andres Puustusmaa mängufilm "18-14" esilinastub 10. jaanuaril Eestis. Lisaks tõlge filmi tutvustavast tekstist (www.1814.ru) : "Tsarskoje Selo Kõrilõikaja ja lütseumi kasvandikud". Artikkel rubriigis "Teatriküljed 1/25"

  12. Kan vi lære af de andre?

    DEFF Research Database (Denmark)

    Christiansen, Rene B; Schlüntz, Ditte Annette; Christensen, Ove

    Kan vi lære af de andre? Udenlandske erfaringer med e-læring og blended learning i erhvervsuddannelser og læreruddannelser for erhvervsskolelærere er en afrapportering af et forsøgs og udviklingsprojekt, der har haft til formål at udvikle koncepter og modeller for e-læring og blended learning i...... forankrede? • Hvilken virkning har brugen af e-læring og blended learning for forskellige uddannelsesinstitutioner? Forsøgs- og udviklingsarbejdet har således haft fokus på at finde og udvikle modeller og koncepter for e-læring og blended læring, der har størst mulig læringseffekt, så danske erhvervsskoler...... erhvervsuddannelserne og læreruddannelsen for erhvervsskolelærere. Projektet har undersøgt og systematiseret udenlandske erfaringer med virkningen af e-læring og blended learning med henblik på at udlede erfaringer om de betingelser, der gør, at en given uddannelsesinstitution har udbytte af at inddrage e-læring og...

  13. Afståelsesret og andre former for lejerskifte

    DEFF Research Database (Denmark)

    Faber, Louise

    Afståelsesret og andre former for lejerskifte indeholder en analyse af lejerens adgang til at overdrage sit lejemål til en ny lejer.  Bogen bygger på forfatterens ph.d. afhandling.  Bogen er opdelt i to dele, en almindelig del, og en speciel del. I bogens almindelige del undersøges spørgsmålet, om...... lejerens ret til lejerskifte, når der ikke er taget stilling i lejeaftalen. Her fastlægges baggrundsretten med udgangspunkt i de obligationsretlige grundsætninger. I denne kontekst beskrives fremlejeretten, lejerens nærtståendes forsættelses- eller overtagelsesret ved lejrens død, skilsmisse m.v., og...... tillige retstillingen når lejeaftalen er indgået med flere lejere, et I/S, et ApS eller et A/S.  I bogens specielle del undersøges lejerens ret til at afstå eller genindtræde lejeforholdet, når lejerens har afståelsesret og genindtrædelsesret ifølge af lejeaftalen. Denne undersøgelse berører udlejerens...

  14. Les visages ambigues d'André Breton

    Directory of Open Access Journals (Sweden)

    Mimi Podkrižnik

    2003-12-01

    Full Text Available L'article porte sur une machinerie d'images du célebre pilier du mouvement surréaliste français André Breton. Cette figure extraordinaire, mais aussi contradictoire, a d'un côté changé la vie et la vision de tous ceux qui l'ont connue, et n'a en meme temps cessé de changer aussi sa propre façon d'etre. Une personnalité hors du commun, qui écrit des livres et des lettres, qui parle a haute voix, qui s'engage politiquement, qui s'exile, qui est cible de ses adversaires, reste souvent dogmatique en public, mais parle beaucoup plus librement en privé. Pere fouettard qui a ses interdits, ses tabous, qui crie familles je vous hais et ne peut supporter la métamorphose de ses disciples, se métamorphose en un pere et (plus tard fils aimable. Celui qui veut appartenir a la famille des grands indésirables, trouve sa place parmi les plus grands désirables du 20e siecle.

  15. Arturo Andrés Roig, lector de Spinoza Arturo Andrés Roig, Spinoza Reader

    Directory of Open Access Journals (Sweden)

    Gerardo Oviedo

    2010-06-01

    Full Text Available La categoría spinoziana de conatus ocupa un puesto central en la arquitectónica discursiva de la filosofía práctica de Arturo Andrés Roig. Se trata de un fundamento previo del saber práctico-moral que oficia de figura explicativa originaria, pues el conatus concierne a una dimensión primaria de los entes. Su status teórico no se reduce por tanto a reconocer un aspecto antropológico entre otros, sino que adquiere un carácter vertebrador en el conjunto de las estrategias de fundamentación de la idea de "moral emergente" propuesta por nuestro filósofo. Nosotros estimamos que la condición ontológica del conatus es una instancia determinante de los planteos éticos y políticos de Arturo Roig. Dicha inflexión spinozista tan patente, sin embargo, no es tenida suficientemente en cuenta en algunas lecturas especializadas de la Argentina. En consecuencia, nos proponemos en primer término destacar la función constructiva que ese momento spinoziano posee en el pensamiento del maestro mendocino, ciñéndonos a un tratamiento de los textos en donde esa fuerza conceptual se torna más visible, sin excluir por cierto otros tratamientos concomitantes. Ello nos permitirá, en un segundo nivel más historiográfico de análisis, revalorar la recepción de Spinoza en los escritos de Arturo Roig.The Spinoza conatus category occupies a central place in the architectural discourse of practical philosophy of Arturo Andres Roig. This is a preliminary basis of practical knowledge and moral figure that offers originating explanation, as the conatus concerns a primary dimension of entities. Its theoretical status is not reduced only to recognizing anthropological aspect among others, but acquires a backbone in the set of strategies to substantiate the idea of "emerging moral" given by our philosopher. We believe that the ontological status is an instance of conatus determinant of ethical and political layout of Arturo Roig. Spinoza said turning so clearly

  16. Retrospective study of RAS/PIK3CA/BRAF tumor mutations as predictors of response to first-line chemotherapy with bevacizumab in metastatic colorectal cancer patients.

    Science.gov (United States)

    Nakayama, Izuma; Shinozaki, Eiji; Matsushima, Tomohiro; Wakatsuki, Takeru; Ogura, Mariko; Ichimura, Takashi; Ozaka, Masato; Takahari, Daisuke; Suenaga, Mitsukuni; Chin, Keisho; Mizunuma, Nobuyuki; Yamaguchi, Kensei

    2017-01-09

    After analysis of minor RAS mutations (KRAS exon 3, 4/NRAS) in the FIRE-3 and PRIME studies, an expanded range of RAS mutations were established as a negative predictive marker for the efficacy of anti-EGFR antibody treatment. BRAF and PIK3CA mutations may be candidate biomarkers for anti-EGFR targeted therapies. However, it remains unknown whether RAS/PIK3CA/BRAF tumor mutations can predict the efficacy of bevacizumab in metastatic colorectal cancer. We assessed whether selection according to RAS/PIK3CA/BRAF mutational status could be beneficial for patients treated with bevacizumab as first-line treatment for metastatic colorectal cancer. Of the 1001 consecutive colorectal cancer patients examined for RAS, PIK3CA, and BRAF tumor mutations using a multiplex kit (Luminex®), we studied 90 patients who received combination chemotherapy with bevacizumab as first-line treatment for metastatic colorectal cancer. The objective response rate (ORR) and progression-free survival (PFS) were evaluated according to mutational status. The ORR was higher among patients with wild-type tumors (64.3%) compared to those with tumors that were only wild type with respect to KRAS exon 2 (54.8%), and the differences in ORR between patients with wild-type and mutant-type tumors were greater when considering only KRAS exon 2 mutations (6.8%) rather than RAS/PIK3CA/BRAF mutations (18.4%). There were no statistically significant differences in ORR or PFS between all wild-type tumors and tumors carrying any of the mutations. Multivariate analysis revealed that liver metastasis and RAS and BRAF mutations were independent negative factors for disease progression after first-line treatment with bevacizumab. Patient selection according to RAS/PIK3CA/BRAF mutations could help select patients who will achieve a better response to bevacizumab treatment. We found no clinical benefit of restricting combination therapy with bevacizumab for metastatic colorectal cancer patients with EGFR-wild type

  17. mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer.

    Science.gov (United States)

    Chen, Yaqing; Qian, Jianchang; He, Qun; Zhao, Hui; Toral-Barza, Lourdes; Shi, Celine; Zhang, Xuesai; Wu, Jiang; Yu, Ker

    2016-05-03

    The mechanistic target of rapamycin (mTOR) is a major regulator of cell growth and is frequently dysregulated in cancer. While mTOR complex-1 (mTORC1) is a validated cancer target, the role of mTOR complex-2 (mTORC2) remains less defined. Here, we reveal mTORC2 as a critical regulator of breast cancer metabolism. We showed that hyperphosphorylation in ATP citrate lyase (ACL) occurs frequently in human breast tumors and correlates well with HER2+ and/or PIK3CA-mutant (HER2+/PIK3CAmut) status in breast tumor cell lines. In HER2+/PIK3CAmut cells, mTORC2 controls Ser-455 phosphorylation of ACL thereby promoting acetyl-CoA production, de novo lipogenesis and mitochondrial physiology, all of which were inhibited by an mTORC1/mTORC2 kinase inhibitor (mTOR-KI) or cellular depletion of mTORC2 or ACL. mTOR-KI but not rapamycin blocked the IGF-1-induced ACL phosphorylation and glucose to lipid conversion. Depletion of mTORC2 but not mTORC1 specifically inhibited the ACL-dependent acetyl-CoA production. In the HER2+/PIK3CAmut MDA361, MDA453, BT-474 and T47D cells, depletion of mTORC2 or ACL led to growth inhibition and mitochondrial hyperpolarization, which were partially rescued by an alternate source of acetyl-CoA. These same changes were not apparent in mTORC2- or ACL-depleted HER2-/PIK3CAwt MDA231 and HCC1806 cells, highlighting a differential dependence of mTORC2-ACL for survival in these two cell types. Moreover, ACL Ser-455 mutants S455E (phosphomimetic) and S455A (non-phosphorylatable) each increased or decreased, respectively, the acetyl-CoA production, mitochondrial homeostasis and survival in ACL-depleted MDA453 cells. These studies define a new and rapamycin-resistant mechanism of mTORC2-ACL in lipogenesis and acetyl-CoA biology and provide a rationale for targeting of mTORC1 and mTORC2 in HER2+/PIK3CAmut breast cancer.

  18. CERN celebrates André Martin’s 80th birthday

    CERN Multimedia

    2009-01-01

    André Martin, pictured at the ceremony held in honour of his 80th birthday. On 27 August 2009 CERN’s Main Auditorium was the venue for a celebration in honour of André Martin’s 80th birthday. Regarded as one of the most important theoretical physicists of his generation, André Martin is one of CERN’s most distinguished figures. The celebration began with a conference, followed by a concert and a reception. After the conference, André Martin made an emotional speech looking back over his fifty-year career and paying tribute to all those who had made important contributions during his time at CERN. "I was extremely happy, and I am very touched by this marvellous celebration you have organised for me. It was a wonderful idea, and I very much enjoyed the concert of Blandine Eynaud and John Devore. My wife, Schu, and I love the music of Gabriel Fauré", he said at the end. André Martin j...

  19. Energy Transition Initiative: Island Energy Snapshot - San Andres and Providencia (Fact Sheet); NREL(National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-03-01

    This profile provides a snapshot of the energy landscape of the Archipelago of San Andres, Providencia, and Santa Catalina (unpopulated), also known as San Andres and Providencia, which is equidistant between Costa Rica and Jamaica and 775 kilometers northwest of Colombia. The archipelago is part of Colombia, though Nicaragua has also laid claim to it.

  20. Andrés Chiautla, Estado de México

    Directory of Open Access Journals (Sweden)

    J. Tiburcio-Rosales

    2007-01-01

    Full Text Available En el presente trabajo se realizó un Ordenamiento Ecológico Territorial del municipio de San Andrés Chiautla. La metodología empleada fue la propuesta por el INE-SEMARNAP, la cual emplea la variante de los sistemas complejos asociados a la metodología de SEDUE, utilizando las variantes del Levantamiento Fisiográfico realizado a través del SIG para la caracterización de los subsistemas natural y socioeconómico; así como la utilización de los términos de referencia para las transformaciones y permanencias del uso del suelo obtenidos del Programa Estatal de Ordenamiento Territorial elaborado por SEDESOL. Se generaron ocho productos como resultado de la etapa de caracterización del subsistema natural y socioeconómico los cuales son: la calidad ecológica de los recursos naturales, la fragilidad natural, los cambios del uso del suelo y vegetación, la presión de la población sobre su entorno natural, la distribución de la población, los niveles de bienestar de la población, la dinámica espacial y temporal de la población y los aspectos socioeconómicos. Después de la etapa de caracterización se llevó a cabo la integración del subsistema natural para obtener la estabilidad ambiental y las políticas ambientales. Como resultado final se obtuvieron las tablas de uso, políticas y criterios para normalizar la utilización del espacio territorial.

  1. Shedding Light on the Sea: André Morel's Legacy to Optical Oceanography

    Science.gov (United States)

    Antoine, David; Babin, Marcel; Berthon, Jean-François; Bricaud, Annick; Gentili, Bernard; Loisel, Hubert; Maritorena, Stéphane; Stramski, Dariusz

    2014-01-01

    André Morel (1933-2012) was a prominent pioneer of modern optical oceanography, enabling significant advances in this field. Through his forward thinking and research over more than 40 years, he made key contributions that this field needed to grow and to reach its current status. This article first summarizes his career and then successively covers different aspects of optical oceanography where he made significant contributions, from fundamental work on optical properties of water and particles to global oceanographic applications using satellite ocean color observations. At the end, we share our views on André's legacy to our research field and scientific community.

  2. Shedding light on the sea: André Morel's legacy to optical oceanography.

    Science.gov (United States)

    Antoine, David; Babin, Marcel; Berthon, Jean-François; Bricaud, Annick; Gentili, Bernard; Loisel, Hubert; Maritorena, Stéphane; Stramski, Dariusz

    2014-01-01

    André Morel (1933-2012) was a prominent pioneer of modern optical oceanography, enabling significant advances in this field. Through his forward thinking and research over more than 40 years, he made key contributions that this field needed to grow and to reach its current status. This article first summarizes his career and then successively covers different aspects of optical oceanography where he made significant contributions, from fundamental work on optical properties of water and particles to global oceanographic applications using satellite ocean color observations. At the end, we share our views on André's legacy to our research field and scientific community.

  3. Andróginos y ciborgs: monstruos de deconstrucción

    OpenAIRE

    Sánchez Anguix, Ana

    2015-01-01

    Resumen En nuestro corpus, conformado por obras literarias y cinematográficas, los cuerpos monstruosos del ciborg y del andrógino devienen seres fronterizos que cuestionan los parámetros de sexo, género y deseo. Lo humano es puesto en duda y lo invisible se vuelve visible, abriendo un amplio espectro en la naturaleza. En el presente estudio se examinan las figuras del andrógino y del ciborg a la luz de las teorías de género: por un lado, se estudia el lugar de ambos monstruos en el feminismo...

  4. Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma: Occurence and prognostic significance.

    Science.gov (United States)

    Módos, Orsolya; Reis, Henning; Niedworok, Christian; Rübben, Herbert; Szendröi, Attila; Szász, Marcell A; Tímár, József; Baghy, Kornélia; Kovalszky, Ilona; Golabek, Tomasz; Chlosta, Piotr; Okon, Krzysztof; Peyronnet, Benoit; Mathieu, Romain; Shariat, Shahrokh F; Hollósi, Péter; Nyirády, Péter; Szarvas, Tibor

    2016-06-28

    Targeted therapy represents an attractive alternative for rare tumors such as urachal carcinoma (UrC). The aim of this study was to assess the mutations of the most commonly affected 5 genes in the targetable EGFR-pathway in UrC and comapre their frequencies to those of found in urothelial and colorectal cancer. Mutational hot-spots of selected genes were tested in 22 UrC samples by pyrosequencing. Mutational patterns were compared to those published for colorectal and urothelial cancers. Furthermore, we sought correlations between mutations and clinicopathological and follow-up data. We found 11 mutations in 10 of 22 (45%) patients. The most frequently mutated gene was KRAS (27%) followed by BRAF (18%) and NRAS (5%), while no mutations were detected in the EGFR and PIK3CA genes. No correlation was found between the mutation status and clinicopathological parameters (Sheldon/Mayo stage, tumor grade, metastases). Furthermore, none of the mutations correlated with progression-free or overall survival. The mutation pattern of UrC is more similar to colorectal than to urothelial cancer. However, the mutation characteristics of UrC seems to be unique suggesting that clinical decision-making for UrC cannot be simply adopted from urothelial or colorectal carcinoma. The high occurence of EGFR-pathway mutations warrants the testing for KRAS and BRAF mutations when considering anti-EGFR therapy in UrC.

  5. PIK3CA and TP53 gene mutations in human breast cancer tumors frequently detected by ion torrent DNA sequencing.

    Science.gov (United States)

    Bai, Xusheng; Zhang, Enke; Ye, Hua; Nandakumar, Vijayalakshmi; Wang, Zhuo; Chen, Lihong; Tang, Chuanning; Li, Jianhui; Li, Huijin; Zhang, Wei; Han, Wei; Lou, Feng; Zhang, Dandan; Sun, Hong; Dong, Haichao; Zhang, Guangchun; Liu, Zhiyuan; Dong, Zhishou; Guo, Baishuai; Yan, He; Yan, Chaowei; Wang, Lu; Su, Ziyi; Li, Yangyang; Jones, Lindsey; Huang, Xue F; Chen, Si-Yi; Gao, Jinglong

    2014-01-01

    Breast cancer is the most common malignancy and the leading cause of cancer deaths in women worldwide. While specific genetic mutations have been linked to 5-10% of breast cancer cases, other environmental and epigenetic factors influence the development and progression of the cancer. Since unique mutations patterns have been observed in individual cancer samples, identification and characterization of the distinctive breast cancer molecular profile is needed to develop more effective target therapies. Until recently, identifying genetic cancer mutations via personalized DNA sequencing was impractical and expensive. The recent technological advancements in next-generation DNA sequencing, such as the semiconductor-based Ion Torrent sequencing platform, has made DNA sequencing cost and time effective with more reliable results. Using the Ion Torrent Ampliseq Cancer Panel, we sequenced 737 loci from 45 cancer-related genes to identify genetic mutations in 105 human breast cancer samples. The sequencing analysis revealed missense mutations in PIK3CA, and TP53 genes in the breast cancer samples of various histologic types. Thus, this study demonstrates the necessity of sequencing individual human cancers in order to develop personalized drugs or combination therapies to effectively target individual, breast cancer-specific mutations.

  6. FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.

    Directory of Open Access Journals (Sweden)

    Lucie C Kompier

    Full Text Available BACKGROUND: Fifty percent of patients with muscle-invasive bladder cancer (MI-BC die from their disease and current chemotherapy treatment only marginally increases survival. Novel therapies targeting receptor tyrosine kinases or activated oncogenes may improve outcome. Hence, it is necessary to stratify patients based on mutations in relevant oncogenes. Patients with non-muscle-invasive bladder cancer (NMI-BC have excellent survival, however two-thirds develop recurrences. Tumor specific mutations can be used to detect recurrences in urine assays, presenting a more patient-friendly diagnostic procedure than cystoscopy. METHODOLOGY/PRINCIPAL FINDINGS: To address these issues, we developed a mutation assay for the simultaneous detection of 19 possible mutations in the HRAS, KRAS, and NRAS genes. With this assay and mutation assays for the FGFR3 and PIK3CA oncogenes, we screened primary bladder tumors of 257 patients and 184 recurrences from 54 patients. Additionally, in primary tumors p53 expression was obtained by immunohistochemistry. Of primary tumors 64% were mutant for FGFR3, 11% for RAS, 24% for PIK3CA, and 26% for p53. FGFR3 mutations were mutually exclusive with RAS mutations (p = 0.001 and co-occurred with PIK3CA mutations (p = 0.016. P53 overexpression was mutually exclusive with PIK3CA and FGFR3 mutations (p≤0.029. Mutations in the RAS and PIK3CA genes were not predictors for recurrence-free, progression-free and disease-specific survival. In patients presenting with NMI-BC grade 3 and MI-BC, 33 and 36% of the primary tumors were mutant. In patients with low-grade NMI-BC, 88% of the primary tumors carried a mutation and 88% of the recurrences were mutant. CONCLUSIONS/SIGNIFICANCE: The mutation assays present a companion diagnostic to define patients for targeted therapies. In addition, the assays are a potential biomarker to detect recurrences during surveillance. We showed that 88% of patients presenting with low-grade NMI

  7. FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.

    Science.gov (United States)

    Kompier, Lucie C; Lurkin, Irene; van der Aa, Madelon N M; van Rhijn, Bas W G; van der Kwast, Theo H; Zwarthoff, Ellen C

    2010-11-03

    Fifty percent of patients with muscle-invasive bladder cancer (MI-BC) die from their disease and current chemotherapy treatment only marginally increases survival. Novel therapies targeting receptor tyrosine kinases or activated oncogenes may improve outcome. Hence, it is necessary to stratify patients based on mutations in relevant oncogenes. Patients with non-muscle-invasive bladder cancer (NMI-BC) have excellent survival, however two-thirds develop recurrences. Tumor specific mutations can be used to detect recurrences in urine assays, presenting a more patient-friendly diagnostic procedure than cystoscopy. To address these issues, we developed a mutation assay for the simultaneous detection of 19 possible mutations in the HRAS, KRAS, and NRAS genes. With this assay and mutation assays for the FGFR3 and PIK3CA oncogenes, we screened primary bladder tumors of 257 patients and 184 recurrences from 54 patients. Additionally, in primary tumors p53 expression was obtained by immunohistochemistry. Of primary tumors 64% were mutant for FGFR3, 11% for RAS, 24% for PIK3CA, and 26% for p53. FGFR3 mutations were mutually exclusive with RAS mutations (p = 0.001) and co-occurred with PIK3CA mutations (p = 0.016). P53 overexpression was mutually exclusive with PIK3CA and FGFR3 mutations (p≤0.029). Mutations in the RAS and PIK3CA genes were not predictors for recurrence-free, progression-free and disease-specific survival. In patients presenting with NMI-BC grade 3 and MI-BC, 33 and 36% of the primary tumors were mutant. In patients with low-grade NMI-BC, 88% of the primary tumors carried a mutation and 88% of the recurrences were mutant. The mutation assays present a companion diagnostic to define patients for targeted therapies. In addition, the assays are a potential biomarker to detect recurrences during surveillance. We showed that 88% of patients presenting with low-grade NMI-BC are eligible for such a follow-up. This may contribute to a reduction in the number

  8. BRAF, PIK3CA, and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal Cancers with Distant Metastasis.

    Directory of Open Access Journals (Sweden)

    Soo Kyung Nam

    Full Text Available Anti-EGFR antibody-based treatment is an important therapeutic strategy for advanced colorectal cancer (CRC; despite this, several mutations--including KRAS, BRAF, and PIK3CA mutations, and HER2 amplification--are associated with the mechanisms underlying the development of resistance to anti-EGFR therapy. The aim of our study was to investigate the frequencies and clinical implications of these genetic alterations in advanced CRC.KRAS, BRAF, and PIK3CA mutations were determined by Cobas real-time polymerase chain reaction (PCR in 191 advanced CRC patients with distant metastasis. Microsatellite instability (MSI status was determined by a fragmentation assay and HER2 amplification was assessed by silver in situ hybridization. In addition, KRAS mutations were investigated by the Sanger sequencing method in 97 of 191 CRC cases.Mutations in KRAS, BRAF, and PIK3CA were found in 104 (54.5%, 6 (3.1%, and 25 (13.1% cases of advanced CRC, respectively. MSI-high status and HER2 amplification were observed in 3 (1.6% and 16 (8.4% cases, respectively. PIK3CA mutations were more frequently found in KRAS mutant type (18.3% than KRAS wild type (6.9% (P = 0.020. In contrast, HER2 amplifications and BRAF mutations were associated with KRAS wild type with borderline significance (P = 0.052 and 0.094, respectively. In combined analyses with KRAS, BRAF and HER2 status, BRAF mutations or HER2 amplifications were associated with the worst prognosis in the wild type KRAS group (P = 0.004. When comparing the efficacy of detection methods, the results of real time PCR analysis revealed 56 of 97 (57.7% CRC cases with KRAS mutations, whereas Sanger sequencing revealed 49 cases (50.5%.KRAS mutations were found in 54.5% of advanced CRC patients. Our results support that subgrouping using PIK3CA and BRAF mutation or HER2 amplification status, in addition to KRAS mutation status, is helpful for managing advanced CRC patients.

  9. y religion bautista en San Andrés Isla

    Directory of Open Access Journals (Sweden)

    Natalia Guevara

    2006-01-01

    Full Text Available El presente artículo aborda de manera general los nexos de los pastores y la religión bautista con el movimiento autonomista raizal de la isla de San Andrés. El documento brinda un panorama breve sobre la relación del Estado colombiano con el Archipiélago, la cual incluyó la censura a la lengua inglesa y criolla y a la religión protestante. Así, el artículo establece los orígenes de la participación de las iglesias bautistas en las reivindicaciones a favor de la identidad isleña en la resistencia de los pastores y los fieles protestantes ante las políticas integracionistas nacionales que surgían en el marco de la nación monocultural proclamada en la constitución de 1886. Si bien, a partir de la década de 1960 la resistencia raizal se manifestó en diversos movimientos de carácter secular, a finales de la década de 1990 los pastores retomaron el liderazgo en las demandas por la defensa de la identidad isleña mediante un discurso religioso que se entremezcla con lo político tanto en el espacio de la iglesia como en manifestaciones públicas realizadas en la isla. El artículo propone que el papel de los pastores en el movimiento raizal puede ser comprendido, por una parte, mediante la tradición antiesclavista de la religión bautista a lo largo del Caribe anglófono y, por otra, por la influencia de la iglesia en la vida social isleña como un indicador de respetabilidad, lo cual le permite convocar a la comunidad y ampliar el alcance de las demandas autonomistas del movimiento raizal. Finalmente, el documento plantea que el papel de los pastores como mediadores se enmarca dentro de una tradición más amplia de resolución pacífica del conflicto, expresada en el Caribe mediante la polirritmia, la cual permite la coexistencia de diversas tendencias que no se excluyen mutuamente.

  10. Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer.

    Science.gov (United States)

    Juanpere, Nuria; Agell, Laia; Lorenzo, Marta; de Muga, Silvia; López-Vilaró, Laura; Murillo, Raquel; Mojal, Sergi; Serrano, Sergio; Lorente, José A; Lloreta, Josep; Hernández, Silvia

    2012-10-01

    Different members of the phosphoinositide 3 kinase--serine threonine protein kinase (PI3K-AKT) pathway are altered in bladder cancer. Fibroblast growth factor receptor 3 (FGFR3) mutations characterize the low-grade tumors, and RAS genes are mutated in approximately 13% of all bladder tumors. Interestingly, a percentage of bladder tumors have alterations in more than 1 PI3K-AKT or rat sarcoma viral oncogene homolog-RAF mitogen activated protein kinase (RAS-MAPK) pathway gene or their upstream regulators, but some combinations are mutually exclusive. We analyzed mutations in FGFR3, phosphoinositide 3 kinase catalytic alpha polypeptide (PIK3CA), v-akt murine thymoma viral oncogene homolog 1 (AKT1), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS), and v-raf murine sarcoma viral oncogene homolog B1 (BRAF) in 88 urothelial cell carcinomas and the immunohistochemical expression of phospho-v-akt murine thymoma viral oncogene homolog (AKT) and mitogen-activated protein kinase 1 and 2 (pERK1/2) in 80 and 77 urothelial cell carcinomas, respectively. Approximately 43% and 20.5% of tumors presented 1 and 2 mutated genes, respectively. FGFR3 mutations were more frequent alone, whereas PIK3CA mutations were associated with another mutated gene (FGFR3 and KRAS). Overall, mutated FGFR3 (FGFR3(mut)) and mutated FGFR3 (FGFR3(mut))-mutated PIK3CA (PIK3CA(mut)) genotypes were associated with low-grade bladder tumors and mutated PIK3CA (PIK3CA(mut))-mutated KRAS (KRAS(mut)) and mutated AKT1 (AKT1(mut)) were only present in high-grade tumors. There are no mutated FGFR3 (FGFR3(mut))-mutated RAS (RAS(mut)) nor mutated PIK3CA (PIK3CA(mut))-mutated AKT1 (AKT1(mut)) combinations. Fifty percent and 56% of tumors showed high levels of pAKT and pERK1/2, respectively. High levels of pAKT were associated with total mutations, FGFR3(mut), and PIK3CA(mut) tumors but not with tumor grade or stage. Wild-type tumors presented

  11. Theory in Psychology ( Review essay of Andre Kukla, Methods of Theoretical Psychology).

    NARCIS (Netherlands)

    Looren De Jong, H.; Bem, S.; Schouten, M.K.D.

    2004-01-01

    This review essay critically discusses Andre Kukla's Methods of theoretical psychology. It is argued that Kukla mistakenly tries to build his case for theorizing in psychology as a separate discipline on a dubious distinction between theory and observation. He then argues that the demise of

  12. Baltoscandal on lõppenud, uued mõtted on saadud / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2006-01-01

    Eesti teater oli Baltoscandalil koondatud olematu teatri mõiste alla. Andres Noormetsa "Reunioon", Mart Kangro ja Ansambel U "Mäng", Marco Laimre "Vangistus", Asko Künnapi "Säälpool jõge", Anders Härmi "Cooking and Shitting", Sven Kuntu "Miks Eesti mehed ei tantsi?", Linnar Priimäe "Inimese lõhn"

  13. Giving Voice: Narrating silence, history and memory in André Brink ...

    African Journals Online (AJOL)

    This essay examines André Brink's two most recent novels, The Other Side of Silence (2002) and Before I Forget (2004), in terms of their voicing of silence and the rewriting of history and memory. Each has a theme familiar to Brink's readers – an historical story of colonial violence and violation avenged; and the recounting ...

  14. [Rets. rmt. : Glucksmann, Andre. Ouest contre Ouest. Pariis, 2003] / Malle Talvet

    Index Scriptorium Estoniae

    Talvet, Malle

    2004-01-01

    Prantsuse filosoofi Andre Glucksmanni raamat "Ouest contre Ouest" ehk "Lääs Lääne vastu" käsitleb rahvusvahelisi sündmusi 2002/2003, eelkõige Iraaki, terrorismi, Ameerika Ühendriike ja Prantsusmaad

  15. Kaitseväe korralduse seadus muudab asjaajamise lihtsamaks ja selgemaks / Andres Anvelt ; interv. Liivi Parrest

    Index Scriptorium Estoniae

    Anvelt, Andres, 1969-

    2008-01-01

    Kaitseväe korralduse seaduse rakendamise projektirühma juht Andres Anvelt selgitab muudatusi 1. jaan 2009 kehtima hakkavas seaduses. Lisatud: § 57. Seaduse rakendamine ; § 37. Kaitseväe volitused kaitseväeluure teostamisel ; § 41. Osalemine julgeolekuasutuste tegevuses ; § 23. Kaitseväe juhtimise alused

  16. Giving Voice: Narrating silence, history and memory in André Brink ...

    African Journals Online (AJOL)

    Both narrators, though, draw attention to the problems associated with this reconstructive and potentially appropriative storytelling. These texts thereby enact, in a more complex way than many of Brink's previous novels, the intersections of narrative, history and memory. Key Words: André Brink, The Other Side of Silence, ...

  17. Today, Icarus: On the persistence of André Bazin’s myth of total cinema

    NARCIS (Netherlands)

    Joret, B.

    2015-01-01

    By means of an in-depth exegesis of André Bazin’s (1918-1958) film critical work, this study explains the significance of his notion of "myth" in relation to history, technology, and perspective, and examines several references to religious, scientific and poetic frameworks. Throughout his oeuvre,

  18. "Riigikogu hoone 90" = "Estonian parliament building 90" / Janno Roos, Andres Labi

    Index Scriptorium Estoniae

    Roos, Janno, 1976-

    2013-01-01

    Eesti Sisearhitektide Liidu 2012. aasta näituse kujunduse preemia pälvinud näitusest (Lossiplats 1A). Kujunduse autorid Janno Roos ja Andres Labi (Ruumilabor). Kuraator Mait Väljas. Graafiline disain: Identity. Sisearhitekti ja ESLi aastapreemiate žürii liikme Mari Kurismaa ning arhitektuuriajaloolase Leele Välja arvamused

  19. Abjeção em textos de André Sant’Anna

    Directory of Open Access Journals (Sweden)

    Leandro Salgueirinho

    2009-07-01

    Full Text Available Trata-se de uma leitura de textos do escritor André Sant’Anna a partir da problematização que, em The Return of the Real (1986, o crítico de arte norte-americano Hal Foster faz da noção de abjeto e da dita abject art.

  20. Samoje doverennoje litso gossudarstva / Andres Lipstok ; interv. Areg Arutjunjan, interv. Aleksandr Ikonnikov

    Index Scriptorium Estoniae

    Lipstok, Andres, 1957-

    2007-01-01

    Eesti Panga president Eesti Panga majandusprognoosist lähitulevikuks, võimalikust majanduskriisist, USA kinnisvarakriisi mõjust Eestile, Eesti krooni võimalikust devalveerimisest, Eesti Panga rahapoliitikast, kommertspankades hoitavate hoiuste tagamisest, oma tööst, lemmikautomargist, toidueelistustest, lemmikharrastustest ning edukusest. Lisa: Andres Lipstok

  1. Exploration, Invention and Imagination: The Myth of Icarus in André Bazin

    NARCIS (Netherlands)

    Joret, B.; Viegas, S.; Teixeira, M.T.

    2015-01-01

    In this essay, I intend to elucidate the ontological implications of André Bazin’s integral realism: "a recreation of the world in its own image." The connection that he draws between the world and the image is in harmony with his mythical project for cinema, which argues that an imaginative myth

  2. Maramaa elust poksi ja graffitini / Andres Lepik, Ott Aardam ; interv. Gert Kiiler

    Index Scriptorium Estoniae

    Lepik, Andres

    2008-01-01

    Ugala teater alustas 89. hooaega. Esimese poole plaanitud esietendused : Toomas Suumani "Linnapea" Heiki Raudla raamatu "August Maramaa aeg" järgi, lavastaja Andres Lepik. Ott Aardami noortetükist "Poks", lavastaja autor. Gerald Sibleyras' "Grafiti", lavastaja Taago Tubin. Silvia Soro jõulunäidend "Inetu pardipoja" ainetel, lavastaja Oleg Titov

  3. Teised meist : Moskvalased Andres Söödi loomingust : filmiõhtu stenogrammist

    Index Scriptorium Estoniae

    1985-01-01

    Andrei Plahhov, Sergei Starodubtsev, Maia Merkel, Larissa Fissunova, Lev Rošal, Sergei Muratov ja Etel Otševerova Andres Söödi dokumentaalfilmidest "Dirigendid" ("Tallinnfilm", 1975), "Jaanipäev" ("Tallinnfilm", 1978), "Reporter" ("Tallinnfilm", 1981), "Mälu" ("Tallinnfilm", 1984)

  4. Andres Herkel : Venemaa esindaja ENPA presidendiks ei sobi / Haldi Ellam, Ravil Khair Al-Din

    Index Scriptorium Estoniae

    Ellam, Haldi

    2007-01-01

    Vene ajalehe Kommersant väitel on Eesti parlamendi süüdistused ENPA presidendi Rene van der Lindeni vastu seotud Mihhail Margelovi võimaliku valimisega uueks presidendiks. Kristiina Ojuland ja Andres Herkel lükkavad väite tagasi

  5. Andres Ehin tähistas sünnipäeva raamatuesitlusega / Maire Kõrver

    Index Scriptorium Estoniae

    Kõrver, Maire, 1961-

    2006-01-01

    Andres Ehin esitles oma luulekogu "Põdrapõrnikapääsukene" ja selle ingliskeelset tõlget "Moose Beetle Swallow" oma sünnipäeval Iiri suursaadiku residentsis, kus oli kohal ka luulekogu tõlkija, Iiri luuletaja Patrick Cotter

  6. San Andrés: Cotidianidad turística vs. idealismo desarrollista

    Directory of Open Access Journals (Sweden)

    José Ernesto Ramírez

    1988-01-01

    Full Text Available Pragmatic adaptation and idealistic intervention: An analytical description of development agencies within a context of political clientelism in San Andrés Island Colombia. (Tesis de doctorado en desarrollo. University Madison Wisconsin, 1980 Michael Jack Rosherg. University Microfilm Intemational. Ann Arbor, 1982, 301 págs. 6 ils. 40 cuadros.

  7. André Latarjet (1877-1947). Anatomist and surgeon specialized in sports medicine.

    Science.gov (United States)

    Romero-Reverón, Rafael A

    2014-01-01

    André Latarjet (1877-1947), physician and surgeon, outstanding professor of anatomy, made important contributions to the study of human anatomy. He was the disciple and successor of Dr. Leo Testut and continued the diffusion of his work. He was a member of the French Academy of Medicine and President of the International Federation of Sports Medicine.

  8. Arhitekt ja insener Andres Ringo / Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Randküla, Ell-Maaja, 1939-2016

    2004-01-01

    Andres Ringo elust, tööst, projektidest, tema arvamus tänasest linnaplaneerimisest jm. 1991. a. asutas A. Ringo koos Ell Väärtnõuga Väärtnõu ja Ringo Arhitektuuribüroo. Kommentaar arhitekt Martti Preemilt. 5 ill

  9. Sõnajalad: meilt pole väljamõistetud sentigi / Oleg Sõnajalg, Andres Sõnajalg ; intervjueerinud Tuuli Koch

    Index Scriptorium Estoniae

    Sõnajalg, Oleg

    2009-01-01

    Ettevõtjad Oleg ja Andres Sõnajalg räägivad telekanali TV1 loomisest, selle probleemidest ning müügist, oma firma AS Ämärlärd tegevusest, selle firmaga seotud süüdistustest ning oma teistest tegevustest

  10. Tõnu Anton kahtlustab linnaisasid omakasu jahtimises / Tõnu Anton, Andres Kõiv, Ando Hagel ; interv. Ulis Guth

    Index Scriptorium Estoniae

    Anton, Tõnu, 1942-

    2004-01-01

    Võru linnavolikogu opositsiooni kuuluv keskerakondlane Tõnu Anton kritiseerib sotsiaalabitalituse ruumide remondirahade kasutamist ja kahtlustab linnavalitsust riigihangete käigus raha kõrvaldamises. Linnapea Ando Hagel ja abilinnapea Andres Kõiv lükkavad süüdistused tagasi

  11. SUTD-i koorik = SUTD Gridshell / Andres Sevtšuk, Raul Kalvo

    Index Scriptorium Estoniae

    Sevtšuk, Andres, 1981-

    2013-01-01

    Singapuri Tehnoloogia ja Disaini Ülikooli (SUTD) raamatukogu paviljon. Eskiis valmis esimese aasta üliõpilastele korraldatud töötoas. Algse ideega töötas edasi City Form Lab (arhitektid Andres Sevtšuk, Raul Kalvo). Paviljon pandi kokku ligi saja üliõpilase osalusel. Valmis: mai 2013

  12. What history tells us III. André Lwoff: From protozoology to molecular ...

    Indian Academy of Sciences (India)

    2005-11-15

    Nov 15, 2005 ... Home; Journals; Journal of Biosciences; Volume 30; Issue 5. What history tells us III. André Lwoff: From protozoology to molecular definition of viruses. Michel Morange. Series Volume 30 Issue 5 December 2005 pp 591-594. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. Vallavanemate hinnang aastatele 2008 ja 2009 / Jüri Lillsoo, Kalmer Märtson, Andre Sepp

    Index Scriptorium Estoniae

    Lillsoo, Jüri, 1943-

    2009-01-01

    Milline oli aasta 2008 Teie valla jaoks, kui silmas pidada kiiret süvenevat majanduslangust? Mida oodata aastast 2009?Küsimustele vastavad Anija vallavanem Jüri Lillsoo, Kuusalu vallavanem Kalmer Märtson ja Raasiku vallavanem Andre Sepp

  14. Pühajärve veekeskus = Pühajärve Spa / Andres Alver

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2004-01-01

    Projekteerija: Alver Trummal Arhitektid. Autorid Andres Alver, Indrek Rünkla, Ulla Mets, Tarmo Laht, sisekujundaja Helle Neemre, konstruktor Väino Taidur. Projekt 2002, valmis 2003. I ja II korruse plaan, lõige, 2 välis- ja 5 sisevaadet

  15. Lapsevanemad protestivad KG-s 1. klassi võtmise katsete alusel / Andres Sepp

    Index Scriptorium Estoniae

    Sepp, Andres, 1976-

    2004-01-01

    Kuressaare Gümnaasiumist välja jäänud 7-aastase poisi vanemad Meeli ja Andres Lauk kutsuvad oma protestiga ühinema kõiki teisi lapsevanemaid, kes peavad õigustamatuks laste kooli võtmist katsete alusel

  16. Perekonnad hoiavad kontrolli tuntud suurfirmade tegevuse üle / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2005-01-01

    Andres Haamer räägib oma perefirma Overall Eesti loomisest. Uniprindi-Unipressi omanikud Sirje ja Andrus Reinsoo hindavad koos oma äri peatrumpideks täielikku usaldust ja teineteisemõistmist. Lisad: Maailma legend: Rockefellerid; Eesti legend: Puhkid

  17. Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer.

    Science.gov (United States)

    Gonzalez-Angulo, Ana M; Chen, Huiqin; Karuturi, Meghan S; Chavez-MacGregor, Mariana; Tsavachidis, Spyrus; Meric-Bernstam, Funda; Do, Kim-Anh; Hortobagyi, Gabriel N; Thompson, Patricia A; Mills, Gordon B; Bondy, Melissa L; Blumenschein, George R

    2013-01-01

    The current study was conducted to determine the frequency and association between recurrence-free survival (RFS) and MET and catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevations in patients with early stage breast cancer. Tumor DNA was extracted from 971 formalin-fixed, paraffin-embedded early breast cancers for molecular inversion probes arrays. Data were segmented using the single-nucleotide polymorphism (SNP)-FASST2 segmentation algorithm. Copy number gains were called when the copy number of each segment was greater than 2.3 or 1.7, respectively. RFS was estimated by the Kaplan-Meier method. Cox proportional hazards models were fit to determine independent associations between copy number and RFS. Of the 971 tumors studied, 82 (8.44%) and 134 (13.8%) had an elevation of the MET or PIK3CA copy number, respectively, and 25.6% of tumors with a MET copy number elevation had a PIK3CA copy number elevation. Patients with either a MET or PI3KCA high copy number tended to have poorer prognostic features (larger tumor size, higher tumor grade, and hormone receptor negativity). Both MET and PIK3CA high copy numbers were more likely to occur in patients with triple receptor-negative disease (P = .019 and P number and MET normal/low copy number, respectively (P = .06) and 73.1%, and 82.3% for PIK3CA high copy number and PIK3CA normal/low copy number, respectively (P = .15). A high copy number for either gene was not found to be an independent predictor of RFS. A high copy number of MET or PIK3CA was found to be associated with poorer prognostic features and triple receptor-negative disease. Coamplification was frequent. Patients with tumors with high MET copy numbers tended to have a worse RFS. Copyright © 2012 American Cancer Society.

  18. Montage, Militancy, Metaphysics: Chris Marker and André Bazin

    Directory of Open Access Journals (Sweden)

    Sarah Cooper

    2010-01-01

    Full Text Available

     

    Abstract (E: This article focuses on the relationship between the work of André Bazin and Chris Marker from the late 1940s through to the late 1950s and beyond. The division between Bazin's ŘRight Bankř affiliation with Les Cahiers du Cinéma on the one hand, and Markerřs ŘLeft Bankř allegiances on the other, is called into question here as my argument seeks to muddy the waters of their conventional ideological separation across the river Seine. Working alliteratively through Markerřs well-known talent for deft montage along with his militancy, I consider Bazinřs praise for Markerřs editing technique Ŕ in spite of famously expressing a preference elsewhere for the long take, and deep focus cinematography Ŕ and I address their political differences and convergences. Yet I also explore the rather more unexpected question of metaphysics in order to further emphasize a closer relationship between these two figures. I chart the emergence of an enduring spiritual bond between critic and filmmaker that surfaces first in Markerřs writings for the left-wing Catholic journal L’EspritPahede koht on ajaloo prügikastis! Kas ikka on? / Andres Maimik, Maris Jesse ; intervjueerinud Sigrid Kõiv

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    2009-01-01

    Proua Evelin Ilves tegi ettepaneku, et arstid võiksid inimesi innustada isikliku eeskujuga ja viia ennast tervislikku vormi. Filmimees Andres Maimik ja terviseedendaja Maris Jesse arutavad, kas on võimalik pahelisi eluviise välja juurida

  19. Ületades piire = Crossing the Bordes / Anders Härm, Tarmo Maiste ; interv. Andres Kurg, Triin Ojari

    Index Scriptorium Estoniae

    Härm, Anders, 1977-

    2000-01-01

    Intervjuu Veneetsia 7. arhitektuuribiennaali Eesti ekspositsiooni "Simulacrum City" autorite Anders Härmi ja Tarmo Maistega. Eesti väljapanekust (arhitektuurifotod - Arne Maasik; filmi, stsenaarium ja kontseptsioon - Andres Maimik, Jaak Kilmi, muusika - Taavi Laatsit), biennaalist. 13 ill

  1. Coexistence of EGFR with KRAS, or BRAF, or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohorts

    Science.gov (United States)

    Li, S; Li, L; Zhu, Y; Huang, C; Qin, Y; Liu, H; Ren-Heidenreich, L; Shi, B; Ren, H; Chu, X; Kang, J; Wang, W; Xu, J; Tang, K; Yang, H; Zheng, Y; He, J; Yu, G; Liang, N

    2014-01-01

    Background: Determining the somatic mutations of epidermal growth factor receptor (EGFR)-pathway networks is the key to effective treatment for non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitors (TKIs).The somatic mutation frequencies and their association with gender, smoking history and histology was analysed and reported in this study. Methods: Five thousand one hundred and twenty-five NSCLC patients' pathology samples were collected, and EGFR, KRAS, BRAF and PIK3CA mutations were detected by multiplex testing. The mutation status of EGFR, KRAS, BRAF and PIK3CA and their association with gender, age, smoking history and histological type were evaluated by appropriate statistical analysis. Results: EGFR, KRAS, BRAF and PIK3CA mutation rates revealed 36.2%, 8.4%, 0.5% and 3.3%, respectively, across the 5125 pathology samples. For the first time, evidence of KRAS mutations were detected in two female, non-smoking patients, age 5 and 14, with NSCLC. Furthermore, we identified 153 double and coexisting mutations and 7 triple mutations. Interestingly, the second drug-resistant mutations, T790M or E545K, were found in 44 samples from patients who had never received TKI treatments. Conclusions: EGFR exons 19, 20 and 21, and BRAF mutations tend to happen in females and non-smokers, whereas KRAS mutations were more inclined to males and smokers. Activating and resistant mutations to EGFR-TKI drugs can coexist and ‘second drug-resistant mutations', T790M or E545K, may be primary mutations in some patients. These results will help oncologists to decide candidates for mutation testing and EGFR-TKI treatment. PMID:24743704

  2. Mutation analysis of CTNNB1 gene and the ras pathway genes KRAS, NRAS, BRAF, and PIK3CA in eyelid sebaceous carcinomas.

    Science.gov (United States)

    Kwon, Mi Jung; Nam, Eun Sook; Cho, Seong Jin; Park, Hye-Rim; Min, Soo Kee; Seo, Jinwon; Choe, Ji-Young

    2017-06-01

    Sebaceous carcinoma (SC) represents a rare, aggressive eyelid malignancy with poor prognosis and is a possible component of Muir-Torre syndrome. However, genetic features as driver mutations or potential therapeutic targets are not fully elucidated. Recent a few studies have shown that SCs have concurrently multiple mutations including RAS/RAF/MAPK and PI3K/Akt pathways via next-generation sequencing in western population. Because we recently demonstrated absence of KRAS mutations in Korean eyelid SCs, we extended our previous study to the analysis of NRAS, BRAF, PIK3CA, and CTNNB1 mutations, and the examination of related protein expressions in 15 eyelid SCs. Repeated molecular analysis by peptide nucleic acid-mediated PCR clamping method, PNA clamping-assisted fluorescence melting curve analysis, and direct sequencing revealed that all eyelid SCs had wild type alleles of NRAS, BRAF, and PIK3CA in hotspot exon locations. Only silent mutations in the CTNNB1 gene (p.Q61Q) were identified. Using immunohistochemistry and microsatellite instability analysis, they harbored all intact mismatch repair gene proteins with microsatellite stability. Membranous and cytoplasmic β-catenin staining was found in all tumors, whereas the one third of those tumors showed cyclin D1 overexpression, of which 40% and 80% showed p53 expression and p16 expression, respectively. The lack of KRAS, NRAS, BRAF, and PIK3CA mutation in our study may suggest that a subset of eyelid SCs is unlike that of eyelid SCs of western countries. The mismatch repair gene proteins and microsatellite instability analysis as a screening test for Muir-Torre syndrome may be limited in the Korean eyelid SCs. Copyright © 2017 Elsevier GmbH. All rights reserved.

  3. PIK3CG single nucleotide polymorphisms are associated with poor responsiveness to clopidogrel and increased risk of ischemia in patients with coronary heart disease.

    Science.gov (United States)

    Li, Ke-Cheng; Yu, Shu-Hong; Zhuge, Bao-Zhong

    2017-09-01

    This study explores the associations between PIK3CG single nucleotide polymorphisms (SNPs, rs1129293 and rs17398575) and patient responsiveness to clopidogrel to evaluate the risks of ischemia in patients with coronary heart disease (CHD). The study consisted of 513 CHD patients who received clopidogrel as part of antiplatelet therapy, after percutaneous coronary intervention. According to the patient responsiveness to clopidogrel, the subjects were assigned to either clopidogrel-resistant (CR) or clopidogrel-sensitive (CS) groups. CR group was determined by patients' platelet aggregation rate of ≥70% and poor responsiveness to clopidogrel, and CS group by patients' platelet aggregation rates of clopidogrel. Polymerase chain reaction using TaqMan probe was employed to detect PIK3CG polymorphism. Haplotype and linkage disequilibrium analyses were performed. Prognosis analysis was performed using the Kaplan-Meier curve. Significant difference was found in genotype and rs1129293 and rs17398575 allele frequency between the CR and CS groups. Haplotype analysis indicated that the frequency of TG allele was higher in the CR group compared with the CS group, and the frequency of CA allele was lower in the CR group compared with the CS group. Patients with rs1129293 CT + TT genotype and T allele, rs1129293 AG + GG genotype and G allele exhibited an increased CR risk. Logistic regression analysis determined hypertension history as an independent risk factor for CR. The Kaplan-Meier curve suggests that distribution curve of cumulative probability nonischemic events was different between patients with rs1129293 and rs17398575 alleles. Stable CHD patients with TT genotype of rs1129293 allele and GG genotype of rs17398575 allele showed poorer prognosis compared to those with other genotypes and patients with acute coronary syndromes. A positive correlation may exist between PIK3CG SNPs (rs1129293 and rs17398575) and patients with poor responsiveness to clopidogrel. These

  4. A Phase II Trial of Neoadjuvant MK-2206, an AKT Inhibitor, with Anastrozole in Clinical Stage II or III PIK3CA-Mutant ER-Positive and HER2-Negative Breast Cancer.

    Science.gov (United States)

    Ma, Cynthia X; Suman, Vera; Goetz, Matthew P; Northfelt, Donald; Burkard, Mark E; Ademuyiwa, Foluso; Naughton, Michael; Margenthaler, Julie; Aft, Rebecca; Gray, Richard; Tevaarwerk, Amye; Wilke, Lee; Haddad, Tufia; Moynihan, Timothy; Loprinzi, Charles; Hieken, Tina; Barnell, Erica K; Skidmore, Zachary L; Feng, Yan-Yang; Krysiak, Kilannin; Hoog, Jeremy; Guo, Zhanfang; Nehring, Leslie; Wisinski, Kari B; Mardis, Elaine; Hagemann, Ian S; Vij, Kiran; Sanati, Souzan; Al-Kateb, Hussam; Griffith, Obi L; Griffith, Malachi; Doyle, Laurence; Erlichman, Charles; Ellis, Matthew J

    2017-09-05

    Purpose: Hyperactivation of AKT is common and associated with endocrine resistance in estrogen receptor-positive (ER(+)) breast cancer. The allosteric pan-AKT inhibitor MK-2206 induced apoptosis in PIK3CA-mutant ER(+) breast cancer under estrogen-deprived condition in preclinical studies. This neoadjuvant phase II trial was therefore conducted to test the hypothesis that adding MK-2206 to anastrozole induces pathologic complete response (pCR) in PIK3CA mutant ER(+) breast cancer.Experimental Design: Potential eligible patients with clinical stage II/III ER(+)/HER2(-) breast cancer were preregistered and received anastrozole (goserelin if premenopausal) for 28 days in cycle 0 pending tumor PIK3CA sequencing. Patients positive for PIK3CA mutation in the tumor were eligible to start MK-2206 (150 mg orally weekly, with prophylactic prednisone) on cycle 1 day 2 (C1D2) and to receive a maximum of four 28-day cycles of combination therapy before surgery. Serial biopsies were collected at preregistration, C1D1 and C1D17.Results: Fifty-one patients preregistered and 16 of 22 with PIK3CA-mutant tumors received study drug. Three patients went off study due to C1D17 Ki67 >10% (n = 2) and toxicity (n = 1). Thirteen patients completed neoadjuvant therapy followed by surgery. No pCRs were observed. Rash was common. MK-2206 did not further suppress cell proliferation and did not induce apoptosis on C1D17 biopsies. Although AKT phosphorylation was reduced, PRAS40 phosphorylation at C1D17 after MK-2206 persisted. One patient acquired an ESR1 mutation at surgery.Conclusions: MK-2206 is unlikely to add to the efficacy of anastrozole alone in PIK3CA-mutant ER(+) breast cancer and should not be studied further in the target patient population. Clin Cancer Res; 1-10. ©2017 AACR. ©2017 American Association for Cancer Research.

  5. O ofício à Rainha Santa Isabel, de André de Resende

    OpenAIRE

    Toipa, Helena Costa

    2011-01-01

    Com o desenvolvimento do culto oficial da Rainha Santa Isabel (então, apenas beata), no século XVI, em Coimbra, o humanista André de Resende compôs e fez imprimir um ofício divino, para substituição de um outro, menos elaborado, utilizado pelas freiras do Mosteiro de Santa Claraa-Velha. Esse ofício consta dos autos do processo instaurado conducente à canonização da Rainha, no início do século XVII. Para a sua composição, no que diz respeito à componente das Lectiones, André de Resende inspiro...

  6. Europan 7 Eestis : Lasnamäe. Pärnu / Tiit Trummal, Andres Kurg

    Index Scriptorium Estoniae

    Trummal, Tiit, 1954-

    2004-01-01

    Võistluse "Äärelinna võimalus, linnalik intensiivsus ja elamise mitmekesisus" Eesti-Rootsi ühisžüriis Eestist Urmas Muru, Tiit Trummal, Andres Kurg. Tallinna Lasnamäe (14 tööd) ja Pärnu (47 tööd) võistlusalast, võitnud tööde arhitektide loetelu ja võitnud töödest. Lasnamäe: I preemia - autor hispaanlane Andres Fernandes Atela, kaasautorid prantslased Mathieu Andrieu ja Iman Morshedi. Pärnu: I preemia - autorid rumeenlane Oana-Maria Bogdan, ameeriklane Susan Kelly Shannon, argentiinlane Laura Vescina, hispaanlased Juny Llach ja Parra Colacios

  7. Lean versus Quick Response Manufacturing og andre koncepter - er Lean den eneste ene?

    DEFF Research Database (Denmark)

    Michelsen, Aage U

    2005-01-01

    principper fra andre koncepter? Artiklen er opdelt i fire hovedafsnit. I første afsnit skitseres baggrunden for Lean. I andet afsnit skitseres kort indholdet i Lean. I tredje afsnit skitseres tankegangen bag Quick Response Manufacturing - et begreb, der har mange ligheder med Lean, men som har fokus på......Begrebet Lean har gennem de senere år vundet en enorm udbredelse. Antallet af publikationer om Lean har været eksplosivt stigende, og mange virksomheder har gennemført eller gennemfører Lean-projekter. Er Lean et nyt koncept? Er Lean den eneste løsning? Kan Lean kombineres med tankegange og...... løsning af en anden produktionsopgave. I fjerde afsnit skitseres kort relationerne mellem Lean og to andre begreber, Six Sigma og TPM, der begge har samme mål som Lean, men forskellige udgangspunkter og forskellige indfaldsvinkler....

  8. Séminaire de probabilités XXXIX in memoriam Paul-André Meyer

    CERN Document Server

    Yor, Marc

    2006-01-01

    The 39th volume of Séminaire de Probabilités is a tribute to the memory of Paul André Meyer. His life and achievements are recalled; homages are rendered by his friends and colleagues. This volume also contains mathematical contributions to classical and quantum stochastic calculus, the theory of processes, martingales and their applications to mathematical finance, Brownian motion. They provide an overview on the current trends of stochastic calculus.

  9. Redescription and biological aspects of Hormathia alba (Andres, 1881), a luminescent sea anemone (Anthozoa, Actiniaria)

    Science.gov (United States)

    Tur, J. M.

    1993-06-01

    The sea anemone Hormathia alba (Andres, 1881) is redescribed and definitely established as distinct from H. coronata. Synonymy, external morphology, anatomy and cnidom are treated in detail. Aspects of its reproduction, ecology, distribution and distinctive characteristics are also reported. The species, largely mistaken throughout literature, is rather common on Mediterranean infralittoral soft bottoms. It has also been found in the SW of Ireland. This is the only known sea anemone with luminescence, a feature that has never been reported before.

  10. Andrés Laguna: a great medical humanist (1499-1559).

    Science.gov (United States)

    Kousoulis, Antonis A; Karamanou, Marianna; Androutsos, George

    2011-01-01

    Andrés Laguna, a Spanish humanist physician of the 16th century, occupies an important position in the history of medicine. An illustrious and brilliant mind, pioneer of anatomy and urology, Laguna proved to be a true pacifist and humanitarian with his knowledge standards and his political eloquence. He deserves to be remembered today as the perfect example of the Renaissance men, a true Homo Universalis.

  11. Andrés Laguna in Papal Rome: the documents of the Mozoncillo ecclesiastical benefice

    OpenAIRE

    Nelson Novoa, James W.

    2012-01-01

    The article renders public and presents the archival documents, hitherto unpublished, regarding an ecclesiastical benefice in the town of Mozoncillo, which Andrés Laguna obtained in 1548. Through the said benefice, obtained, very likely, through the intervention of an important Spanish prelate, Laguna strove to obtain influence and legitimacy for himself and his family in his hometown and contribute to the eradication of the "stain" of his family's converso origins. The documents attest to an...

  12. The interior capture of life. Le Corbusier and André Malraux

    OpenAIRE

    Ana Sofía Pereira da Silva

    2016-01-01

    Abstract Le Corbusier and André Malraux, two important characters from the cultural scene of the 20th century, were contemporaneous. Their thoughts are built  by unlinking from from chronological and local points of view. The  resemblance found in several manifestations during their lives show the  existent affinity between these two authors, contributing to a more sharp  definition of modernism, associated, partially, to their tight relationships to plastic arts. Writings from both au...

  13. [Medical mission of Louis-André Gosse during his trip to Greece (1827-1829)].

    Science.gov (United States)

    Bouvier-Bron, M

    1991-01-01

    Louis-André Gosse (1791-1873), a liberal-minded Geneva physician, went to Greece in 1827 in order to work, for a couple of years, for the Greek State, which had won its independence just a few years ago. When, in 1828, an Egyptian army brought plague back to Greece, Gosse took an active part in the fight against the epidemic. The present author gives a detailed account of Gosse's relation of his experience including treatment and preventive measures.

  14. Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients

    Directory of Open Access Journals (Sweden)

    Silvia N. Kariuki

    2010-01-01

    Full Text Available The PIK3C3 locus was implicated in case-case genome-wide association study of systemic lupus erythematosus (SLE which we had performed to detect genes associated with autoantibodies and serum interferon-alpha (IFN-α. Herein, we examine a PIK3C3 promoter variant (rs3813065/-442 C/T in an independent multiancestral cohort of 478 SLE cases and 522 controls. rs3813065 C was strongly associated with the simultaneous presence of both anti-Ro and anti-Sm antibodies in African-American patients [OR=2.24 (1.34–3.73, P=2.0×10−3]. This autoantibody profile was associated with higher serum IFN-α (P=7.6×10−6. In the HapMap Yoruba population, rs3813065 was associated with differential expression of ERAP2 (P=2.0×10−5, which encodes an enzyme involved in MHC class I peptide processing. Thus, rs3813065 C is associated with a particular autoantibody profile and altered expression of an MHC peptide processing enzyme, suggesting that this variant modulates serologic autoimmunity in African-American SLE patients.

  15. Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer

    Science.gov (United States)

    Wang, Dong; Wang, Min; Jiang, Nan; Zhang, Yuan; Bian, Xing; Wang, Xiaoqing; Roberts, Thomas M.; Zhao, Jean J.; Liu, Pixu; Cheng, Hailing

    2016-01-01

    Recent preclinical studies revealed the efficacy of combined use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib in breast and prostate cancers. The current study investigated the effect of such drug combination on ovarian cancer. Here we showed that combined inhibition of PI3K and PARP effectively synergized to inhibit proliferation, survival and invasion in the majority of ovarian cancer cell lines harboring PIK3CA mutations, including SKOV3, HEYA8, and IGROV1. Mechanistically, combined treatment of PARP and PI3K inhibitors resulted in an exacerbated DNA damage response and more substantially reduced AKT/mTOR signaling when compared to single-agent. Notably, ovarian cancer cells responsive to the PI3K/PARP combination displayed decreased BRCA1/2 expression upon drug treatment. Furthermore, the effect of the drug combination was corroborated in an intraperitoneal dissemination xenograft mouse model in which SKOV3 ovarian cancer cells responded with significantly decreased BRCA1 expression, suppressed PI3K/AKT signaling and reduced tumor burden. Collectively, our data suggested that combined inhibition of PI3K and PARP may be an effective therapeutic strategy for ovarian cancers with PIK3CA mutations and that the accompanied BRCA downregulation following PI3K inhibition could serve as a biomarker for the effective response to PARP inhibition. PMID:26909613

  16. Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Minchul Kim

    2016-09-01

    Full Text Available ARID1A is frequently mutated in ovarian clear cell carcinoma (OCCC and often co-exists with activating mutations of PIK3CA. Although induction of pro-inflammatory cytokines has been observed in this cancer, the mechanism by which the two mutations synergistically activate cytokine genes remains elusive. Here, we established an in vitro model of OCCC by introducing ARID1A knockdown and mutant PIK3CA into a normal human ovarian epithelial cell line, resulting in cell transformation and cytokine gene induction. We demonstrate that loss of ARID1A impairs the recruitment of the Sin3A-HDAC complex, while the PIK3CA mutation releases RelA from IκB, leading to cytokine gene activation. We show that an NF-κB inhibitor partly attenuates the proliferation of OCCC and improves the efficacy of carboplatin both in cell culture and in a mouse model. Our study thus reveals the mechanistic link between ARID1A/PIK3CA mutations and cytokine gene induction in OCCC and suggests that NF-κB inhibition could be a potential therapeutic option.

  17. Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in ≥ 2 line cetuximab-based therapy of colorectal cancer patients.

    Directory of Open Access Journals (Sweden)

    Zacharenia Saridaki

    2011-01-01

    Full Text Available To investigate the predictive significance of KRAS, BRAF, PIK3CA mutational status, AREG- EREG mRNA expression, PTEN protein expression and skin rash in metastatic colorectal cancer (mCRC patients treated with cetuximab containing salvage chemotherapy.Primary tumors from 112 mCRC patients were analyzed. The worst skin toxicity during treatment was recorded.KRAS, BRAF and PIK3CA mutations were present in 37 (33%, 8 (7.2% and 11 (9.8% cases, respectively, PTEN was lost in 21 (19.8% cases, AREG and EREG were overexpressed in 48 (45% and 51 (49% cases. In the whole study population, time to tumor progression (TTP and overall survival (OS was significantly lower in patients with KRAS (p = 0.001 and p = 0.026, respectively or BRAF (p = 0.001 and p<0.0001, respectively mutant tumors, downregulation of AREG (p = 0.018 and p = 0.013, respectively or EREG (p = 0.002 and p = 0.004, respectively and grade 0-1 skin rash (p<0.0001 and p<0.0001, respectively. In KRAS wt patients TTP and OS was significantly lower in patients with BRAF (p = 0.0001 and p<0.0001, respectively mutant tumors, downregulation of AREG (p = 0.021 and p = 0.004, respectively or EREG (p = 0.0001 and p<0.0001, respectively and grade 0-1 skin rash (p<0.0001 and p<0.0001, respectively. TTP was significantly lower in patients with PIK3CA mutations (p = 0.01 or lost PTEN (p = 0.002. Multivariate analysis revealed KRAS (Hazard Ratio [HR] 4.3, p<0.0001, BRAF mutation (HR: 5.1, p<0.0001, EREG low expression (HR: 1.6, p = 0.021 and absence of severe/moderate skin rash (HR: 4.0, p<0.0001 as independent prognostic factors for decreased TTP. Similarly, KRAS (HR 2.9, p = 0.01, BRAF mutation (HR: 3.0, p = 0.001, EREG low expression (HR: 1.7, p = 0.021, absence of severe/moderate skin rash (HR: 3.7, p<0.0001 and the presence of undifferantited tumours (HR: 2.2, p = 0.001 were revealed as independent prognostic factors for decreased OS.These results underscore that KRAS-BRAF mutations and EREG

  18. Book Review: America’s Blind Spot: Chávez, Oil and US Security by Andrés Cala and Michael Economides

    DEFF Research Database (Denmark)

    Boscan, Luis

    2013-01-01

    Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012.......Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012....

  19. Teresa Andrés y la organización Cultura Popular: una propuesta de coordinación bibliotecaria (1936-1938

    Directory of Open Access Journals (Sweden)

    Seguí i Francés, Romà

    2011-12-01

    Full Text Available Teresa Andrés Zamora es conocida por su actividad al frente de la Sección de Bibliotecas de Cultura Popular. Este trabajo describe las relaciones que se establecieron entre Teresa Andrés y Cultura Popular, tras hacerse cargo de las responsabilidades del Ministerio de Instrucción Pública.

  20. Computational Analysis of mRNA Expression Profiles Identifies the ITG Family and PIK3R3 as Crucial Genes for Regulating Triple Negative Breast Cancer Cell Migration

    Directory of Open Access Journals (Sweden)

    Sukhontip Klahan

    2014-01-01

    Full Text Available Triple-negative breast cancer (TNBC is an aggressive type of breast cancer that does not express estrogen receptor (ER, progesterone receptor (PR, and human epidermal growth factor receptor (Her2/neu. TNBC has worse clinical outcomes than other breast cancer subtypes. However, the key molecules and mechanisms of TNBC migration remain unclear. In this study, we compared two normalized microarray datasets from GEO database between Asian (GSE33926 and non-Asian populations (GSE46581 to determine the molecules and common pathways in TNBC migration. We demonstrated that 16 genes in non-Asian samples and 9 genes in Asian samples are related to TNBC migration. In addition, our analytic results showed that 4 genes, PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton. Our results indicated potential genes that link to TNBC migration. This study may help identify novel therapeutic targets for drug development in cancer therapy.

  1. The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Therkildsen, Christina; Bergmann, Troels K; Henrichsen-Schnack, Tine

    2014-01-01

    BACKGROUND: In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS-RAF-MAPK a......BACKGROUND: In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS......-RAF-MAPK and PI3K-AKT-mTOR pathways in colorectal cancer is uncertain, which led us to systematically review the impact of alterations in KRAS (outside of exon 2), NRAS, BRAF, PIK3CA and PTEN in relation to the clinical benefit from anti-EGFR treatment. METHODS: In total, 22 studies that include 2395 patients...

  2. Green moon Festival de San Andrés: El regreso del Muntú

    Directory of Open Access Journals (Sweden)

    Ángel Perea Escobar

    1989-04-01

    Full Text Available San Andrés y Providencia comparten con el complejo afrocaribe los fantásticos y aterradores sucesos históricos antillanos. En la antigüedad constituían una especie de "despensa natural", inhabitada pero hospitalaria, de los indígenas misquitos, cuyo territorio comprendían la vastedad de las costas de Nicaragua y regiones aledañas. La "despensa", además, era compartida por quienes dominaban el escenario antes del asombro de Colón: los arawaks.

  3. Despedida al maestro Arturo Andrés Roig (1922 – 2012

    Directory of Open Access Journals (Sweden)

    Enrique Dussel

    2015-07-01

    Full Text Available En ocasión del fallecimiento de Arturo Andrés Roig (Doctor Honoris Causa por las Universidades Nacional de Río Cuarto, Argentina; Nacional de San Luis, Argentina; Autónoma de Managua, Nicaragua. Profesor Honorario en las Universidades Nacional del Comahue -Argentina-, y Andina Simón Bolívar -Ecuador- queremos sumarnos a la larga serie de homenajes que ha recibido. Para ello, reproducimos aquí tres memoriales dedicados al maestro por filósofos americanos.

  4. Etnic discrimination and income in San Andrés Island, Colombia

    Directory of Open Access Journals (Sweden)

    Javier Yabrudy

    2011-12-01

    Full Text Available This document examines, bases on the analysis of observable characteristics, if an income gapexists between the raizal population and non raizal population of San Andres Island. For thispurpose, the information of the SISBEN II survey for the year 2004, compelled by the NationalPlanning Department (DNP, Spanish acronym is used. The methodological strategy uses quantileregressions to determine the existence of pay gaps throughout the distribution of income. Theresults suggest that being raizal has a negative impact on income for the lower quantiles. However,this difference vanishes as income increases, becoming positive at higher levels.

  5. APA/APAGS Award for Distinguished Graduate Student in Professional Psychology: Octavio Andres Santos.

    Science.gov (United States)

    2017-12-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded annually by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. The 2017 award winner is Octavio Andres Santos, who has demonstrated through several initiatives "effective engagement with advocacy, professional organizations, and research in the area of health disparities and multicultural/multilingual assessment." Santos's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  6. Postharvest quality of tomato fruits cv. Andréa treated with ethylene

    OpenAIRE

    Caroline Andreuccetti; Marcos David Ferreira; Celso Luiz Moretti; Sylvio Luis Honório

    2007-01-01

    O tomate é uma das principais hortaliças cultivadas no Brasil e tratamentos que propiciem o controle do amadurecimento são extremamente desejáveis. Avaliou-se a qualidade pós-colheita de tomates tipo italiano tratados com etileno. Tomates 'Andréa' foram colhidos em campos de produção comercial no estádio verde-maduro, selecionados para presença de danos externos e classificados quanto ao tamanho e cor e posteriormente foram tratados com 100 µL L-1 de etileno. Os ensaios foram planejados com d...

  7. Bioseguridad y armas biológicas: La amenaza de Andrómeda (1971)

    OpenAIRE

    Sánchez Angulo, Manuel

    2011-01-01

    La amenaza de Andrómeda es la adaptación cinematográfica de la obra homónima escrita por Michael Crichton. Puede considerarse como la película más “microbiológica” del Séptimo Arte. Dirigida por Robert Wise, este tecno-thriller describe los esfuerzos de un equipo de científicos para caracterizar y contener a un microorganismo patógeno extraterrestre. A pesar de haber sido realizada hace 40 años, se tratan temas de plena actualidad como es el de las armas biológicas, las medidas de aislamiento...

  8. Andres Bello and the Dissemination of Astronomy: Education and Scientific Rhetoric

    Directory of Open Access Journals (Sweden)

    Verónica Ramírez Errázuriz

    2017-12-01

    Full Text Available This paper analyzes the astronomical texts written by Andres Bello between 1810 and 1848, from its educational nature to its rhetorical expression, suggesting that their main purpose was to show the advances in the field - in terms of knowledge production and also technology development- in order to improve the material and intellectual environment of the nation. It also stands that astronomy should be tought by activating creativity and imagination, which may be linked with Bello’s willing to avoid science and art develop apart from each other, keeping, in this case astronomy bonded with literature.

  9. Inventario de la fauna de hormigas de San Andrés Isla (Colombia

    Directory of Open Access Journals (Sweden)

    Fernández Fernando

    2006-06-01

    Full Text Available En este documento se registra por primera vez información parcial del inventario de las hormigas de San Andrés Isla. Se presenta a continuación un listado de los géneros y se proponen claves ilustradas para subfamilias, tribus y géneros. En total se encontraron 24 géneros: Azteca, Linepithema y Tapinoma de la subfamilia Dolichoderinae; Camponotus, Brachymyrmex y Paratrechina de Formicinae; Pseudomyrmex de Pseudomyrmecinae; Hypoponera, Leptogenys, Odontomachus, Pachycondyla y Platythyrea de Ponerinae; Ectatomma de Ectatomminae y de Myrmicinae: Cyphomyrmex, Wasmannia, Crematogaster, Pyramica, Strumigenys, Cardiocondyla, Pheidole, Monomorium, Solenopsis, Rogeria y Tetramorium.

  10. Localization and adiabatic pumping in a generalized Aubry-André-Harper model

    Science.gov (United States)

    Liu, Fangli; Ghosh, Somnath; Chong, Y. D.

    2015-01-01

    A generalization of the Aubry-André-Harper (AAH) model is developed, containing a tunable phase shift between on-site and off-diagonal modulations. A localization transition can be induced by varying just this phase, keeping all other model parameters constant. The complete localization phase diagram is obtained. Unlike the original AAH model, the generalized model can exhibit a transition between topologically trivial band structures and topologically nontrivial band structures containing protected boundary states. These boundary states can be pumped across the system by adiabatic variations in the phase shift parameter. The model can also be used to demonstrate the phenomenon of adiabatic pumping breakdown due to localization.

  11. Postsotsialismist vaatemängulinna = From Post-Socialism to the City of the Spectacle / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2007-01-01

    Büroo Alver Trummal Arhitektid töödest, Andres Alverist ja Tiit Trummalist. Ärihoonest Tallinnas Rävala pst. 4. Autorid: Andres Alver, Tiit Trummal, Tarmo Laht, Indrek Rünkla, Ulla Mets, Sven Koppel. Konstruktor Eido Uustalu (Eesti Projekt). Projekt 2001, valmis 2006. City Plazast Tallinnas Tartu mnt. 2. Autorid: A. Alver, T. Trummal, T. Laht, I. Rünkla, Martin Melioranski, U. Mets. Konstruktor: Tiit Masso, Pike Projekt. Sisekujundus (fuajeed, restoran): Pille Lausmäe. Projekt 2001, valmis 2004. Lõige, põhiplaan, 3 värv. välis- ja 5 sisevaadet

  12. La astronomía de un humanista, Juan Andrés

    Directory of Open Access Journals (Sweden)

    José Antonio SANDUVETE CHAVES

    2009-11-01

    Full Text Available RESUMEN: La páginas que siguen pretenden ofrecer una visión de conjunto del análisis que de la historia de la Astronomía realiza Juan Andrés, desde los orígenes de la humanidad hasta el siglo XVIII. Este análisis, incluido en su monumental obra Origen, progresos y estado actual de toda la literatura, destaca por su modernidad y precisión, constituyendo, por tanto, una interesante base de comparación entre la visión de la ciencia astronómica del humanismo ilustrado y la que pervive en la actualidad.ABSTRACT: The following pages attempt to offer a full view of the research into the history of astronomy made by Juan Andrés, from the beginning of human culture until the 18th century. This analysis, included in a broader work called Origen, progresos y estado de toda la literatura, stands out on account of its modern and precise ideas, thus representing an interesting knowledge base for comparing the view of astronomy during the Enlightenment with that of the present.

  13. The Amphibians and Reptiles of the Colombian Caribbean Islands San Andrés and Providencia The Amphibians and Reptiles of the Colombian Caribbean Islands San Andrés and Providencia

    Directory of Open Access Journals (Sweden)

    Dunn Emmett Reid

    1945-08-01

    Full Text Available In connection with a study of Central America I have examined specimens from many of the islands off the coast, and I here set down a list of those I have seen from two Colombian islands which rise from deep water about 200 km. east of Nicaragua. They are about 100 km. apart. Both represent old volcanic peaks, and it is unlikely that they were ever connected to each other or to the mainland, although they may have been much larger during a lower glacial sealevel. The herpetological fauna of San Andres and Providencia consists Of: a frog, known from both islands; six lizards, three from both islands and three from Providencia; four snakes, one from San Andrés and three from Providencia. In connection with a study of Central America I have examined specimens from many of the islands off the coast, and I here set down a list of those I have seen from two Colombian islands which rise from deep water about 200 km. east of Nicaragua. They are about 100 km. apart. Both represent old volcanic peaks, and it is unlikely that they were ever connected to each other or to the mainland, although they may have been much larger during a lower glacial sealevel. The herpetological fauna of San Andres and Providencia consists Of: a frog, known from both islands; six lizards, three from both islands and three from Providencia; four snakes, one from San Andrés and three from Providencia.

  14. Karakters en betoog in André P. Brink se Gerugte van reën | van Zyl ...

    African Journals Online (AJOL)

    Gerugte van reën (Rumours of Rain, 1978) is one of André Brink's notorious political novels on apartheid and Afrikaner Nationalism. This essay focuses on the rhetorical processes in the novel and particularly on the use of characterisation as a vehicle for the implied author's ideology. Rhetorically the novel is aimed at ...

  15. Esimene Eesti maja Hiinas = The first Estonian house in China / Andres Põime, Lauri Vaimel ; interv. Triin Ojari

    Index Scriptorium Estoniae

    Põime, Andres

    2008-01-01

    Vestlus Pekingi Eesti saatkonna arhitektuurikonkursi võidutöö autoritega. Tulemused: I preemia - Andres Põime, Lauri Vaimel, II - Erik Nobel, Christian Jensen, Kristen Herup Sovang, Soren Andersson, Pille Kivihall, Dan Ljungar, Hans Willadsen (Taani), III - Kalle Vellevoog, Velle Kadalipp, Tiiu Truus, Martin Prommik

  16. “Note on sex for the aged widower”: On André Brink's The Rights of ...

    African Journals Online (AJOL)

    This article examines the representation of masculinity in André Brink's novel, The Rights of Desire. Following a remark in Roger Boylan's review of the novel in the Boston Review; this analysis concentrates on Brink's depiction of Afrikaner masculinity and the idea that the character Ruben Olivier represents Brink's ...

  17. Optimaalse haridusmudeli poole / Tõnis Lukas, Andres Jõgar, Jüri Ojamaa...[jt.] ; üles kirjutanud Karl Kello

    Index Scriptorium Estoniae

    2009-01-01

    Tartus 3. aprillil toimunud ümarlaua vestlusest, millest võttis osa haridus- ja teadusminister Tõnis Lukas, Kõrvküla Põhikooli direktor Andres Jõgar, Abja Gümnaasiumi direktor Jüri Ojamaa, Nõo vallavanem Rain Sangernebo ja Tartu haridusosakonna juhataja Boris Goldman

  18. The epidemiology and transmissibility of Zika virus in Girardot and San Andres island, Colombia, September 2015 to January 2016

    Science.gov (United States)

    Rojas, DP; Dean, NE; Yang, Y; Kenah, E; Quintero, J; Tomasi, S; Ramirez, EL; Kelly, Y; Castro, C; Carrasquilla, G; Halloran, ME; Longini, IM

    2016-01-01

    Transmission of Zika virus (ZIKV) was first detected in Colombia in September 2015. As of April 2016, Colombia had reported over 65,000 cases of Zika virus disease (ZVD). We analysed daily surveillance data of ZVD cases reported to the health authorities of San Andres and Girardot, Colombia, between September 2015 and January 2016. ZVD was laboratory-confirmed by reverse transcription-polymerase chain reaction (RT-PCR) in the serum of acute cases within five days of symptom onset. We use daily incidence data to estimate the basic reproductive number (R0) in each population. We identified 928 and 1,936 reported ZVD cases from San Andres and Girardot, respectively. The overall attack rate for reported ZVD was 12.13 cases per 1,000 residents of San Andres and 18.43 cases per 1,000 residents of Girardot. Attack rates were significantly higher in females in both municipalities (p < 0.001). Cases occurred in all age groups with highest rates in 20 to 49 year-olds. The estimated R0 for the Zika outbreak was 1.41 (95% confidence interval (CI): 1.15–1.74) in San Andres and 4.61 (95% CI: 4.11–5.16) in Girardot. Transmission of ZIKV is ongoing in the Americas. The estimated R0 from Colombia supports the observed rapid spread. PMID:27452806

  19. Mis juhtus Andres Lapeteusega? : error'ist kõrgklassi homo soveticus'e näitel / Liisa Kaljula

    Index Scriptorium Estoniae

    Kaljula, Liisa, 1982-

    2014-01-01

    Autor analüüsib 2014. a. Tallinna Semiosalongi loengute sarja põhiteema - error'i mõiste avamiseks ühe inimliigi kujunemislugu - Eesti filmiklassikast tuntud tegelaskuju Andres Lapeteuse tõusu ning langust homo soveticus'ena

  20. Lineaarse kunstiajaloo aeg on otsas / Edit András ; intervjueerinud R[eet] V[arblane

    Index Scriptorium Estoniae

    András, Edit

    2010-01-01

    Vestlus ungari kunstiteoreetiku- ja ajaloolase Edit Andrásiga, kes osales Tallinnas USA Clarki instituudi ja EKA Kunstiteaduste Instituudi seminaril, kus arutati Kesk- ja Ida-Euroopa kunstiajaloo kirjutamisviiside üle. Seminari tekkimisest, kokkusaamise põhjustest, seminari järeldustest, Eesti ja Ungari kunstiajaloo kirjutamise erinevatest põhimõtetest jm.

  1. Leptothorax nadigi Kutter, 1925 y Goniomma blanci (André, 1881) : descripción de los machos (Hym. Formicidae)

    OpenAIRE

    Espadaler, Xavier

    1984-01-01

    Se describen los machos de Leptothorax nadigi Kutter y de Goniomma blanci (André). El primero se sitúa cercano a los de L. tuberum (Fab.) y L. nigriceps Mayr. Se da la distribución de G. blanci, no pudiendo compararse con las otras especies ya que el conocimiento de los machos de Goniomma es prácticamente nulo

  2. Earthworm (Clitellata: Megadrili taxonomy in the last 200 years: A homage to András Zicsi (1928−2015

    Directory of Open Access Journals (Sweden)

    Csuzdi, Cs.

    2016-03-01

    Full Text Available Prof. Dr. András Zicsi, the renowned soil biologist and earthworm taxonomist passed away on 22 July, 2015 at the age of 87. To honour his enormous contribution in exploring earthworm biodiversity all over the world, we provide a brief, albeit subjective overview of the history of earthworm taxonomy in the last two century.

  3. "Negro corazón que no soporta la nieve": mecanismos de la (des)memoria en la narrativa conjunta de Simone y André Schwarz-Bart/ "That black heart that fears the snow": memory and oblivion mechanisms in the narrative work of Simone and André Schwarz-Bart

    National Research Council Canada - National Science Library

    Martha Asunción Alonso

    2016-01-01

    ... (1967, Paris, Editions du Seuil), written by Simone and André Schwarz-Bart . We will try to demonstrate that this book is deeply inspired by the famous episode of the madeleine by Marcel Proust. Simone and André...

  4. Impact of KRAS, BRAF, PIK3CA Mutations, PTEN, AREG, EREG Expression and Skin Rash in ≥2nd Line Cetuximab-Based Therapy of Colorectal Cancer Patients

    Science.gov (United States)

    Saridaki, Zacharenia; Tzardi, Maria; Papadaki, Chara; Sfakianaki, Maria; Pega, Fraga; Kalikaki, Aristea; Tsakalaki, Eleftheria; Trypaki, Maria; Messaritakis, Ippokratis; Stathopoulos, Efstathios; Mavroudis, Dimitris; Georgoulias, Vassilis; Souglakos, John

    2011-01-01

    Background To investigate the predictive significance of KRAS, BRAF, PIK3CA mutational status, AREG- EREG mRNA expression, PTEN protein expression and skin rash in metastatic colorectal cancer (mCRC) patients treated with cetuximab containing salvage chemotherapy. Methods Primary tumors from 112 mCRC patients were analyzed. The worst skin toxicity during treatment was recorded. Results KRAS, BRAF and PIK3CA mutations were present in 37 (33%), 8 (7.2%) and 11 (9.8%) cases, respectively, PTEN was lost in 21 (19.8%) cases, AREG and EREG were overexpressed in 48 (45%) and 51 (49%) cases. In the whole study population, time to tumor progression (TTP) and overall survival (OS) was significantly lower in patients with KRAS (p = 0.001 and p = 0.026, respectively) or BRAF (p = 0.001 and p<0.0001, respectively) mutant tumors, downregulation of AREG (p = 0.018 and p = 0.013, respectively) or EREG (p = 0.002 and p = 0.004, respectively) and grade 0-1 skin rash (p<0.0001 and p<0.0001, respectively). In KRAS wt patients TTP and OS was significantly lower in patients with BRAF (p = 0.0001 and p<0.0001, respectively) mutant tumors, downregulation of AREG (p = 0.021 and p = 0.004, respectively) or EREG (p = 0.0001 and p<0.0001, respectively) and grade 0-1 skin rash (p<0.0001 and p<0.0001, respectively). TTP was significantly lower in patients with PIK3CA mutations (p = 0.01) or lost PTEN (p = 0.002). Multivariate analysis revealed KRAS (Hazard Ratio [HR] 4.3, p<0.0001), BRAF mutation (HR: 5.1, p<0.0001), EREG low expression (HR: 1.6, p = 0.021) and absence of severe/moderate skin rash (HR: 4.0, p<0.0001) as independent prognostic factors for decreased TTP. Similarly, KRAS (HR 2.9, p = 0.01), BRAF mutation (HR: 3.0, p = 0.001), EREG low expression (HR: 1.7, p = 0.021), absecence of severe/moderate skin rash (HR: 3.7, p<0.0001) and the presence of undifferantited tumours (HR: 2.2, p = 0.001) were revealed as

  5. Versailles et Philadelphie : Benjamin Franklin et André Michaux

    Directory of Open Access Journals (Sweden)

    James E. McClellan III

    2011-08-01

    Full Text Available On ne peut véritablement parler de « politique scientifique », ni pour les colonies anglaises de l’Amérique, ni pour la nouvelle nation américaine indépendante de la fin du xviiie siècle. Néanmoins, pour la cour de Versailles et pour la politique scientifique française de l’époque – la plus développée du moment – cette région fut d’une grande importance.Dans cette intervention, l’exemple bien connu de Benjamin Franklin ne sera que brièvement évoqué, en tant que scientifique et homme politique, pour les liens qu’il sut tisser entre Versailles et Philadelphie. Le cas moins bien connu, mais plus révélateur, d’André Michaux (1746-1802, botaniste du roi envoyé aux États-Unis en 1785 et chargé de renvoyer en France les semis d’arbres américains, retiendra en revanche davantage notre attention.Pour comprendre la mission d’André Michaux pendant son séjour sur le sol américain jusqu’en 1796, il faut le situer dans le contexte de ce que François Regourd et moi-même avons nommé la machine coloniale, cette nébuleuse institutionnelle scientifique, technique et administrative, dévouée à l’expansion coloniale française. Cette machine intégrait toute une gamme d’institutions à son fonctionnement, y compris, dans le cas d’André Michaux, la Maison et les Bâtiments du roi à Versailles, les jardins du Trianon, le Jardin du roi à Paris, et le Jardin royal d’acclimatation à Rambouillet. Les deux jardins fondés par Michaux dans le New Jersey et en Caroline du Sud firent également partie, à leur manière, de cette machine coloniale et de la politique scientifique de la monarchie française.

  6. Andre rum

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2005-01-01

    I ethvert samfund findes der en række mod-steder - eller alternative samfund - der fremhæver det såkaldt normale liv og samtidig fungerer som et spejl på det almindelige samfund. Det kan være fængslet, plejehjemmet og skibet. Ifølge den franske filosof Michel Foucault har ethvert samfund brug...

  7. Correlation of extended RAS and PIK3CA gene mutation status with outcomes from the phase III AGITG MAX STUDY involving capecitabine alone or in combination with bevacizumab plus or minus mitomycin C in advanced colorectal cancer.

    Science.gov (United States)

    Price, T J; Bruhn, M A; Lee, C K; Hardingham, J E; Townsend, A R; Mann, K P; Simes, J; Weickhardt, A; Wrin, J W; Wilson, K; Gebski, V; Van Hazel, G; Robinson, B; Cunningham, D; Tebbutt, N C

    2015-03-17

    Mutations affecting RAS genes are now established predictive markers of nonresponse to anti-EGFR antibodies in advanced CRC. This analysis assessed the prognostic and predictive impact of extended RAS and PIK3CA gene mutation status in patients receiving capecitabine plus or minus bevacizumab (±mitomycin C) in the randomised phase III MAX study. DNA was extracted from archival macrodissected formalin-fixed paraffin-embedded tumour tissue. Mutation status was determined using pyrosequencing, confirmed with Sanger sequencing (for equivocal RAS) and correlated with efficacy outcomes. Predictive analyses were undertaken using a test for interaction involving both C vs CB+CBM. Of the available 280 of the 471 (59.4%) patients, mutations in KRAS exons 2, 3 and 4 and NRAS 2, 3 and 4 were as follows: 32%, 2.9%, 2.2%, 1.4%, 0.7% and 0% (total RAS MT 39%). The PIK3CA MT rate was 7.5% exon 9 and 3.6% exon 20. Extended RAS gene mutation status (WT vs MT) had no prognostic impact for PFS (HR 0.91 (0.71-1.17)) or OS (HR 0.95 (0.71-1.25)). The RAS gene mutation status was not predictive of the effectiveness of bevacizumab for PFS (HR 0.56 (0.37-0.85) for RAS MT and HR 0.69 (0.5-0.97) for RAS WT; P for interaction 0.50). The PIK3CA mutation was neither predictive for bevacizumab effect nor prognostic. Of KRAS exon 2 WT patients, 10% had additional RAS mutations. Neither all RAS gene mutation status nor PIK3CA mutation status was prognostic for PFS or OS, or predictive of bevacizumab outcome in patients with advanced CRC.

  8. PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab

    DEFF Research Database (Denmark)

    Jensen, J D; Knoop, Ann; Laenkholm, A V

    2012-01-01

    BACKGROUND: This study was conducted to determine the frequency of PIK3CA mutations and human epidermal growth factor receptor-2 (HER2) phosphorylation status (pHER2-Tyr(1221/1222)) and if PIK3CA, phosphatase and tensin homolog (PTEN), or pHER2 has an impact on outcome in HER2-positive early......-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab. PATIENTS AND METHODS: Two hundred and forty HER2-positive early-stage breast cancer patients receiving adjuvant treatment (cyclophosphamide 600 mg/m(2), epirubicin 60 mg/m(2), and fluorouracil 600 mg/m(2)) before administration...... of 1 year trastuzumab were assessable. PTEN and pHER2 expression were assessed by immunohistochemistry. PIK3CA mutations (exons 9 and 20) were determined by pyrosequencing. RESULTS: Five-year overall survival (OS) and invasive disease-free survival were 87.8% and 81.0%, respectively. Twenty-six percent...

  9. Tecnologias digitais: reflexões sobre usos e excessos ilustradas pelos quadrinhos de Andre Dahmer

    Directory of Open Access Journals (Sweden)

    Janaina Cabello

    2015-12-01

    Full Text Available This paper proposes some reflections about possible crossings/impacts on subjective processes from the appropriation of digital technologies in the twenty-first century and how their uses and (alleged excesses have impacted on the subjective constitutions facing other ways humans can show/look/feel/teach, that constitutes the established relationships in the network society. From a historical and cultural perspective, we discuss about the appropriation of digital technologies and the constitutions of subjectivity (individual and in a wider social context, with the backdrop of the illustrations of the Brazilian cartoonist Andre Dahmer, who, through social networks, discloses his work, which provokes and invites us to think about how we relate and therefore, we show and look at ourselves, feel, teach and learn in new subjective configurations with are crossed, constituted and reconstituted by the appropriation of technologies in the contemporary scene.

  10. The interior capture of life. Le Corbusier and André Malraux

    Directory of Open Access Journals (Sweden)

    Ana Sofía Pereira da Silva

    2016-05-01

    Writings from both authors and architectural projects from Le Corbusier –  Mundial Museum, Mundaneum and Museum of Unlimited Growth- will be observed in order to map the existent affinities between the two authors. However, life’s pragmatic circumstances often oppose what uses to be in accordance. André Malraux’s classification of the Villa Savoye, while he was  Minister of the Cultural Affairs, aimed to save one of Le Corbusier’s  masterpieces. Nevertheless, this action banned the architect the possibility to transform the Villa Savoye into a new program (in a first approach and, finally, excluded him the possibility of authorship of the rehabilitation project, which was subsequently entrusted to an architect working in the National Monuments bureau. This suspected moment of friction between the two authors shall be motive of observation.

  11. Bioseguridad y armas biológicas:\tLa amenaza de Andrómeda (1971

    Directory of Open Access Journals (Sweden)

    Manuel SÁNCHEZ

    2016-11-01

    Full Text Available La amenaza de Andrómeda es la adaptación cinematográfica de la obra homónima escrita por Michael Crichton. Puede considerarse como la película más “microbiológica” del Séptimo Arte. Dirigida por Robert Wise, este tecno-thriller describe los esfuerzos de un equipo de científicos para caracterizar y contener a un microorganismo patógeno extraterrestre. A pesar de haber sido realizada hace 40 años, se tratan temas de plena actualidad como es el de las armas biológicas, las medidas de aislamiento y protección, la automatización en los procedimientos sanitarios y la toma de decisiones ante una situación grave e inesperada.

  12. [André Detoeuf (1884-1931): pharmacist, industrialist and chemist].

    Science.gov (United States)

    Leclercq, Loïc

    2011-04-01

    During the transition between the 19th and 20th century, Auguste Béhal (1859-1941), a native of Lens (France, Pas-de-Calais), renewed organic chemistry teaching at the Paris School of Pharmacy by the introduction of atomic notation and pre-electronic mechanisms. This revolution primarily affects the future pharmacists. Thus, Béhal becomes the leader of a "School" of thought and directs the work of many students called "Béhaliens": Ernest Fourneau (1872-1949), Marc Tiffeneau (1873-1945), Marcel Sommelet (1877-1952), etc. Among these students, three are also from Lens: Amand Valeur (1870-1927), Raymond Delaby (1891-1958) and André Detoeuf (1884-1931). The latter, initially, will follow the footsteps of his older siblings (pharmacy studies, writing a thesis under the direction of Behal); however, despite having started a career in academia, he left his post for the industry (Etablissements Kuhlmann and Billault).

  13. Andrés Pérez : una vida para el teatro

    OpenAIRE

    Ceccotti, Francesca

    2009-01-01

    Si pienso en el teatro, más allá de una definición académica del término, pienso en una fiesta y un evento popular con participación “masiva”, pienso en un ritual, en un espacio sagrado y todo eso está presente en el trabajo de Andrés Pérez. Esta es mi verdad, la que voy a contar en este escrito, una verdad subjetiva sin duda y además una verdad que pasa no solo a través de lo efímero del teatro, sino también pasa por los recuerdos de mis testigos, por su memoria, gracias a las entrevistas qu...

  14. Kas toiduainete hind on õiglane? Ei, isegi odav! / Andres Sooniste, Juhan Särgava, Kristjan Kongo, Kati Kusmin ; intervjueerinud Sulev Oll

    Index Scriptorium Estoniae

    2010-01-01

    Vestlusringis toiduainete hindade üle arutamas on Tarbijakaitse ameti peadirektor Andres Sooniste, Põllumeeste Keskliidu president Juhan Särgava, Fazer Eesti ASi juhatuse esimees Kristjan Kongo ja ETK juhatuse esimees Kati Kusmin

  15. Teeleht küsib: mis on teie organisatsiooni ressursid ja valmisolek liiklusohutuse valdkonna edendamiseks? / Joosep Kaasik, Andres Harjo, Martin Harak, Heigo Saare

    Index Scriptorium Estoniae

    2014-01-01

    Vastavad Polisei- ja Piirivalveameti peadirektori asetäitja korrakaitsepolitsei alal Joosep Kaasik, Tallinna Transpordiameti juhataja Andres Harjo, Eesti Autospordi Liidu peasekretär Martin Harak, Tehnilise Järelevalve Ameti raudteeinfrastruktuuri osakonna juhataja Heigo Saare

  16. Notes to the recent reissue of the book Poems of the mothers of Gabriela Mistral With illustrations by André Racz

    National Research Council Canada - National Science Library

    Mónica R. Ravelo García

    2017-01-01

    The book The Mothers’ Poems, combining the verses of Gabriela Mistral and drawings of the artist Andre Racz, has been reissued by Ediciones Radio Universidad de Chile with the support of the National Council for Culture and the Arts (CNCA...

  17. 'Noche es día' de Katia Maciel y André Parente: una reflexión sobre el habitar

    Directory of Open Access Journals (Sweden)

    Alejandro Martín Maldonado

    2016-07-01

    Full Text Available The exhibition, exploring Katia Maciel and André Parente's work, consisted in a multiple refexion of the ways a couple's relationship manifests itself through architectural links.

  18. Patient harboring a novel PIK3CA point mutation after acquired resistance to crizotinib in an adenocarcinoma with ROS1 rearrangement: A case report and literature review.

    Science.gov (United States)

    Xu, Chun-Wei; Wang, Wen-Xian; Huang, Rong-Fang; He, Cheng; Liao, Xing-Hui; Zhu, You-Cai; Du, Kai-Qi; Zhuang, Wu; Chen, Yan-Ping; Chen, Gang; Fang, Mei-Yu

    2017-11-01

    ROS1 rearrangement occurs in 1-2% of non-small cell lung cancer (NSCLC) cases. These patients would benefit from treatment with the anaplastic lymphoma kinase inhibitor, crizotinib; however, resistance to crizotinib inevitably develops in such patients despite an initial response. The mechanism of acquired resistance to crizotinib in patients with NSCLC with ROS1 rearrangement has not yet been identified. Herein, we report a case of a 66-year-old woman diagnosed with adenocarcinoma. PCR revealed no EGFR or ALK mutations. After the patient underwent several rounds of chemotherapy, crizotinib was administered. The disease explosively progressed six months later. A novel PIK3CA gene point mutation (p.L531P) was detected by next generation sequencing. This case is the second report of bypass activation conferred crizotinib resistance in a patient with NSCLC with ROS1-rearrangement, but is the first to confirm that activation of the mTOR signaling pathway leads to acquired crizotinib resistance. © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

  19. The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.

    Directory of Open Access Journals (Sweden)

    Jatin Roper

    Full Text Available To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type colorectal cancer (CRC.PIK3CA mutant and wild-type human CRC cell lines were treated in vitro with NVP-BEZ235, and the resulting effects on proliferation, apoptosis, and signaling were assessed. Colonic tumors from a genetically engineered mouse (GEM model for sporadic wild-type PIK3CA CRC were treated in vivo with NVP-BEZ235. The resulting effects on macroscopic tumor growth/regression, proliferation, apoptosis, angiogenesis, and signaling were examined.In vitro treatment of CRC cell lines with NVP-BEZ235 resulted in transient PI3K blockade, sustained decreases in mTORC1/mTORC2 signaling, and a corresponding decrease in cell viability (median IC(50 = 9.0-14.3 nM. Similar effects were seen in paired isogenic CRC cell lines that differed only in the presence or absence of an activating PIK3CA mutant allele. In vivo treatment of colonic tumor-bearing mice with NVP-BEZ235 resulted in transient PI3K inhibition and sustained blockade of mTORC1/mTORC2 signaling. Longitudinal tumor surveillance by optical colonoscopy demonstrated a 97% increase in tumor size in control mice (p = 0.01 vs. a 43% decrease (p = 0.008 in treated mice. Ex vivo analysis of the NVP-BEZ235-treated tumors demonstrated a 56% decrease in proliferation (p = 0.003, no effects on apoptosis, and a 75% reduction in angiogenesis (p = 0.013.These studies provide the preclinical rationale for studies examining the efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type CRC.

  20. Sarucallis kahawaluokalani (Kirkaldy) (Hemiptera: Aphididae), a new invasive aphid on San Andres island and mainland Colombia, with notes on other adventive species

    OpenAIRE

    Kondo, Takumasa; Cortés, Ronald Simbaqueba

    2014-01-01

    The crape myrtle aphid Sarucallis kahawaluokalani (Kirkaldy) (Hemiptera: Aphididae) collected on Lagerstroemia indica (Lythraceae) is herein reported as a new invasive species in the city of Palmira, State of Valle del Cauca, and on San Andres island, in the State of San Andres, Old Providence and Santa Catalina, Colombia. The species is illustrated and diagnosed. A brief review of recent invasive species in Colombia, i.e., Ceroplastes rubens Maskell (Hemiptera: Coccidae), Crypticerya multici...

  1. Postura y equilibrio de las miniaturas orgánicas del Códice de San Andrés de Arroyo Posture and balance of the organic miniatures of the Codex of San Andrés de Arroyo

    Directory of Open Access Journals (Sweden)

    Adelina Martínez Rodríguez

    2008-03-01

    Full Text Available Los Beatos son códices medievales españoles que hacen referencia al Apocalipsis. El texto está profusamente acompañado de miniaturas con personajes humanos y celestiales. El Beato de San Andrés de Arroyo es uno de ellos. Hemos realizado un análisis anatómico y postural de las figuras que aparecen en estos Beatos. Hemos encontrado figuras humanas y celestiales cuya postura y equilibrio son disarmónicas, contrariando a la fisiología. De otro lado hemos encontrado otras figuras que mantienen un perfecto equilibrio, representando correctamente el movimiento y la estática. Creemos en base a todo ello que en el Beato de San Andrés de Arroyo hubo más de un artista iluminador, uno de ellos era más naturalista que el otro u otros.The Beatuses are Spanish medieval codices that refer to the Apocalypses. Miniatures full of human and celestial characters accompany the text. The Beatus of San Andrés de Arroyo is one of them. We have made an anatomic and postural analysis of the figures of this Beatus. We’ve found human and celestial figures who’s posture and balance are lacking in harmony, contrary to physiology. On the other hand we have found other figures that maintain a perfect balance, representing movement and motionlessness correctly.We believe, based on all this, that there is more than one Beatus de San Andrés de Arroyo illustrator, one of them being more of a naturalist than the other.

  2. Kortlægning og risikovurdering af toluen og andre neurotoksiske stoffer i børneværelset

    DEFF Research Database (Denmark)

    Larsen, Poul Bo; Kolarik, Barbara; Gunnarsen, Lars Bo

    Formålet med projektet var at undersøge om udsættelsen for toluen og andre neurotoksiske stoffer kan være problematiske for børns sundhed. Dette blev vurderet i forhold til den eksponering, børn vil have i et typisk børneværelse, og der blev samtidig taget højde for eksponering fra andre kilder...... eksponeringsniveauer, som blev fundet i emissionsmålingerne, blev der udført opfølgende feltmålinger af de neurotoksiske stoffer i 19 børneværelser. Toluen var det hyppigst fundne stof og blev målt i alle 19 børneværelser. Generelt var de målte koncentrationer i overensstemmelse med resultater fra...

  3. Geología y aspectos geográficos de la isla de san andrés, colombia

    OpenAIRE

    Vargas Cuervo, German

    2012-01-01

    La Isla de San Andrés ha sido definida geológicamente por varios autores en dos unidades calcáreas de características bien marcadas: Una unidad de calizas heterogéneas,denominada como Formación San Andrés de edad Mioceno y una unidad de calizas coralinas de edad Pleistoceno, conocida como Formación San Luis. La primera unidad aflora en la parte central de la isla y representa la zona de colinas suaves con alturas máximas de 87 m.s.n.m y la Formación San Luis constituye la región plana a suave...

  4. André Morain : présence(s) photographique(s), 50 ans d’art contemporain

    OpenAIRE

    Belon, Olivier

    2014-01-01

    Cette monographie consacrée à André Morain, reporter autodidacte, présente principalement un intérêt ethnographique : on y découvre un milieu artistique parisien accompagné parfois de quelques invités prestigieux. Au détour d’un clin d’œil rapide, apparaissent des sourires complices, une connivence généralisée, l’image d’une grande famille internationale soudée et harmonieuse, avec ses patriarches (André Masson) et ses mauvais garçons (Keith Haring). Les lieux sont géographiquement circonscri...

  5. Los “milagros do Bom Jesus” de las Laudes e Cantigas de André Dias

    Directory of Open Access Journals (Sweden)

    María Eugenia Díaz Tena

    2016-09-01

    Full Text Available André Dias Laudes are very important for the medieval spiritual literature in Portugal and no less remarkable are its implications within the ‘parateatralidad’. We refer here, in particular, the Livro dos Milagres do Bom Jesus de S. Domingos de Lisboa, their interesting and juicy introduction, the reason for its inclusion and its role within the work Laudes e Cantigas. We also discuss the use and content of miracles included there.

  6. The social construction of bath in two communities temazcal of the mixteca region: Santiago Yolomecatl and San Andres Chicahuaxtla

    OpenAIRE

    Alberto Valdés Cobos; Anayelit Cruz Galicia

    2013-01-01

    The bathroom of temazcal is a knowledge of pre-Hispanic roots still practiced in rural and indigenous communities in our country. Studies on the temazcal have focused on its forms of construction and operation, however, the many therapeutic benefits temazcal bath attached to the human body, and women in particular, not have been sufficiently documented. In this case, two communities of the Oaxacan mixteca were studied: Santiago Yolomecatl and San Andrés Chicahuaxtla. In this study, a question...

  7. La libertà fragile. Una prospettiva antropologica tra Günther Anders e André Leroi-Gourhan

    Directory of Open Access Journals (Sweden)

    Lorenzo De Stefano

    2013-01-01

    Full Text Available The problem of technology cannot be separated from the problem of man, his nature and his determination. This essay surveys the nexus man-technology in the philosophical perspective of G. Anders, hybridized with André Leroi-Gourhan’s empiric anthropology. Anders philosophical concepts such as promethean gap and Weltfremdheit are investigated following the line of human evolution, that set itself as a process of gradual exoneration from nature in which technology and language play an essential role.

  8. Distribution and infestation levels of Crypticerya multicicatrices Kondo and Unruh (Hemiptera: Monophlebidae on San Andrés island

    Directory of Open Access Journals (Sweden)

    Takumasa Kondo Kondo

    2014-01-01

    Full Text Available The fluted scale Crypticerya multicicatrices (Hemiptera: Monophlebidae is an invasive insect that became a major pest on the island of San Andrés. To generate control strategies for this insect, its distribution and infestation levels on palm species, fruit trees, leguminous trees and other plant species were determined during January 14–18, 2013. A total of 96 points were sampled in order to determine the distribution of the insect on the island. During the study, the fluted scale was found distributed throughout the island of San Andrés, including Haynes Cay and Johnny Cay. The palms were the plants with the highest levels of infestation, 70.8% had some degree of infestation (37.5% high infestation levels; followed by fruit trees which had 65.6% with some degree of infestation (30.2% high infestation levels; followed by leguminous trees which had 59.6% with some degree of infestation (13.5% high infestation levels and finally “other hosts” which had 51.1% with some level of infestation (11.5% high infestation levels. This study is the first detailed mapping of C. multicicatrices on the island of San Andrés which will become the basis for future work on the population dynamics of the fluted scale and its distribution on the island.

  9. Subtypes of HPV-positive head and neck cancers are associated with HPV characteristics, copy number alterations, PIK3CA mutation, and pathway signatures

    Science.gov (United States)

    Zhang, Yanxiao; Koneva, Lada A.; Virani, Shama; Arthur, Anna E.; Virani, Alisha; Hall, Pelle B.; Warden, Charles D.; Carey, Thomas E.; Chepeha, Douglas B.; Prince, Mark E.; McHugh, Jonathan B.; Wolf, Gregory T.; Rozek, Laura S.; Sartor, Maureen A.

    2016-01-01

    Structured Abstract Purpose There is substantial heterogeneity within human papillomavirus (HPV) associated head and neck cancer (HNC) tumors that predispose them to different outcomes, however the molecular heterogeneity in this subgroup is poorly characterized due to various historical reasons. Experimental Design We performed unsupervised gene expression clustering on deeply-annotated (transcriptome and genome) HPV(+) HNC samples from two cohorts (84 total primary tumors), including 18 HPV(−) HNC samples, to discover subtypes and characterize the differences between subgroups in terms of their HPV characteristics, pathway activity, whole-genome somatic copy number alterations and mutation frequencies. Results We identified two distinct HPV(+) subtypes (namely HPV-KRT and HPV-IMU). HPV-KRT is characterized by elevated expression of genes in keratinocyte differentiation and oxidation-reduction process, whereas HPV-IMU has strong immune response and mesenchymal differentiation. The differences in expression are likely connected to the differences in HPV characteristics and genomic changes. HPV-KRT has more genic viral integration, lower E2/E4/E5 expression levels and higher ratio of spliced to full length HPV oncogene E6 than HPV-IMU; the subgroups also show differences in copy number alterations and mutations, in particular the loss of chr16q in HPV-IMU and gain of chr3q and PIK3CA mutation in HPV-KRT. Conclusion Our characterization of two subtypes of HPV(+) HNC tumors provides valuable molecular level information that point to two main carcinogenic paths. Together, these results shed light on stratifications of the HPV(+) HNCs and will help to guide personalized care for HPV(+) HNC patients. PMID:27091409

  10. Faculté des sciences de Bordeaux, René-André Coulon architecte

    Directory of Open Access Journals (Sweden)

    Franck Delorme

    2012-01-01

    Full Text Available Au sortir de la seconde guerre mondiale, les facultés bordelaises étouffent dans leurs locaux du centre-ville édifiés sous la troisième République. Un ambitieux programme de transferts des établissements universitaires vers les banlieues de Pessac, Talence et Gradignan se met en place à partir des années 1950. L’architecte René-André Coulon (1908-1997 conçoit la faculté des sciences de Bordeaux, envisagée alors comme une véritable faculté « pour l’an 2000 ». Tout en disposant largement les différents bâtiments dans l’espace du campus, Coulon s’attache à leur donner un style original, tout empreint de rigueur et de rationalisme, mais qui montre également quelques écarts notables avec les normes régissant alors les constructions universitaires. Talence est la première réalisation universitaire de Coulon, qui travaillera par la suite sur des programmes fort différents, qu’il s’agisse du campus de HEC à Jouy-en-Josas ou de celui de la faculté des sciences de Paris-centre avec Édouard Albert.

  11. Chemical Profile and Antioxidant Activity of the Oil from Peony Seeds (Paeonia suffruticosa Andr.).

    Science.gov (United States)

    Yang, Xin; Zhang, Di; Song, Li-Min; Xu, Qian; Li, Hong; Xu, Hui

    2017-01-01

    Peony seed oil (PSO) is a novel vegetable oil developed from the seeds of Paeonia suffruticosa Andr. The present study aimed to make an overall investigation on the chemical profile and antioxidant activities of PSO for reasonable development and utilization of this new resource food. Chemical analysis revealed that PSO was characterized by an uncommon high portion of α-linolenic acid (>38%), fairly low ratio of n-6 to n-3 polyunsaturated fatty acids (0.69), and much higher content of γ-tocopherol than various conventional seed oils. In vitro assay indicated that PSO is a more potent scavenger of free radicals than extra virgin olive oil. Moderate intake of PSO exhibited obvious protection against various oxidative damages such as tetrachloromethane-induced acute liver injury in mice and diet-induced hyperlipidemia in rats. The changes in the key indicators of oxidative injury and fatty acid composition in the liver caused by PSO administration were measured, and the results demonstrated that antioxidant properties of PSO are closely related to their characteristic chemical composition. Consequently, the present study provided new evidence for the health implications of PSO, which deserves further development for medical and nutritional use against oxidative damages that are associated with various diseases.

  12. san Andrés, Pinar del Río, Cuba

    Directory of Open Access Journals (Sweden)

    N. Valdés-Rodriguez

    2006-01-01

    Full Text Available El presente trabajo se realizó en la Unidad Forestal San Andrés, en el área que corresponde a las alturas de pizarras, tuvo como objetivo realizar una valoración de diferentes aspectos de su morfología y el endemismo de las especies de plantas leñosas acompañantes en los ecosistemas de pinares naturales presentes en esa zona. Para realizar esta valoración se tomaron en cuenta aspectos como el tipo biológico, la textura de la hoja, el tamaño de la planta, la distribución de la especie y la familia de las especies recolectadas en las zonas de muestreo. Se llegó a la conclusión de que la vegetación acompañante se caracteriza por ser especies de pequeño a mediano tamaño, con hojas medianamente pequeñas, y que no existe entre estas especies ninguna endémica a nivel de distrito o local.

  13. Karl Andrée (1880-1959) sedimentologist and marine geologist

    Science.gov (United States)

    Dullo, Wolf-Christian; Pfaffl, Fritz A.

    2017-09-01

    Karl Andrée began studying questions of sedimentology and oceanography in 1908 when working as an assistant at the University of Marburg and he remained faithful to these subjects until his death in 1959. The vast majority of his scientific contributions, however, were published during his time at the University of Königsberg (1915-1945). There he published his fundamental papers on marine geology, all of which adhered strictly to the principles of uniformitarianism, and helped improve our understanding of sedimentary processes and the stratigraphic record. His scientific work has enormous breadth. In the course of 55 years, he published 124 individual papers and books, some of which became classic textbooks. His versatility is particularly evident in his book "Geology of the Seafloor", which contains many pertinent observations and descriptions still relevant today, even if it has fallen out of fashion. This scientist and university teacher was the first to successfully present the huge field of marine geology in all its facet and to consider the deposition of marine sediments as a function of their geographical distribution.

  14. A homosexual militant at the beginning of the century: Marc André Raffalovich.

    Science.gov (United States)

    Cardon, P

    1993-01-01

    This work is based on my thesis from Aix en Provence on French Civilisation and Letters (1984). The head of the examinations was the writer Raymond Jean. My idea is to show how the decadent writer and poet Marc André Raffalovich fought against the personalities in science concerning homosexuality with a new point of view and with great difficulty, shedding new light on this subject in a review from 1886 to 1914 under the direction of Dr. Alexandre Lacassagne Les Archives d'Anthropologie Criminelle de Médecine Légale et de Psychologie Normale et Pathologique published in 1886, edited by the director A. Lacassagne, professor and chairman of legal medicine, Lyon, and author of the article "Pederastie," Dictionnaire Encyclopedique des Sciences Medicales, volume XXII published in 1886. In 1893, he wrote an introduction for l'Inversion Sexuelle of Dr. Julien Chevalier (Paris: Masson-Lyon Storck). This monthly review "d'au moins 80 pages" was called L'Ecole Lyonnaise, and so to say, l'Ecole Francaise d'Anthropologie Criminelle, which defends against l'Ecole Italienne of Lombroso, the culturalist theory of the birth of the criminal; according to this école du milieu social: "La Société a les criminels qu'elle merite" (The society has criminals it deserves). After the first world war, it was to be overridden by the Marxist analysis.

  15. La conquista interior de la vida. Le Corbusier y André Malraux

    Directory of Open Access Journals (Sweden)

    Ana Sofía Pereira da Silva

    2016-05-01

    Escritos de ambos autores y algunas obras de Le Corbusier –Museo Mundial del Mundaneum y Museo de Crecimiento Ilimitado– serán observados con el sentido de mapear las afinidades existentes entre los dos autores. Sin embargo, las circunstancias pragmáticas de la vida a  menudo se entrometen oponiendo lo que suele estar en consonancia. La clasificación de monumento histórico atribuida por André Malraux a la Villa Savoye, mientras fuera Ministro de los Asuntos Culturales, es presentada con la intuición de salvar una de las obras maestras de Le Corbusier. Sin embargo, esta acción terminó impidiendo al arquitecto encontrar en la degradación de la Villa Savoye un pretexto para su transformación, en una primera fase, vetándole también, finalmente, el proyecto de la  restauración de la casa, que es confiada a un arquitecto de los Monumentos Nacionales.2 Este momento intuido de fricción entre los dos  autores será motivo de observación, no arriesgando la evidente afinidad entre los dos.

  16. Música e disco no Brasil: a trajetória de André Midani

    Directory of Open Access Journals (Sweden)

    Eduardo Vicente

    2008-06-01

    Full Text Available Esse artigo tem por objetivo apresentar a trajetória profissional de André Midani, provavelmente o mais importante executivo da história da indústria fonográfica no Brasil. Nascido na Síria, Midani chegou ao Brasil nos anos 50, ingressando imediatamente na indústria. Sua trajetória, desenvolvida especialmente nas gravadoras Odeon (EMI, Phillips/Polygram (Universal Music e Warner, está profundamente ligadas a importantes movimentos da música popular brasileira como a Bossa Nova, o Tropicalismo, a Brazilian Black Music e o Rock Brasileiros dos anos 80. Além disso, o modelo de atuação empregado por Midani- baseado, segundo suas palavras, na promoção do artista e não da música- pode oferecer um interessante contraponto para a discussão do cenário atual e da crise que parece atingir globalmente a indústria do disco.

  17. Quantum walks in the commensurate off-diagonal Aubry-André-Harper model

    Science.gov (United States)

    Wang, Li; Liu, Na; Chen, Shu; Zhang, Yunbo

    2017-01-01

    Due to the topological nature of the Aubry-André-Harper (AAH) model, interesting edge states have been found existing in one-dimensional periodic and quasiperiodic lattices. In this article, we investigate continuous-time quantum walks of identical particles initially located on either edge of commensurate AAH lattices in detail. It is shown that the quantum walker is delocalized among the whole lattice until the strength of periodic modulation is strong enough. The inverse participation ratios (IPRs) for all of the eigenstates are calculated. It is found that the localization properties of the quantum walker is mainly determined by the IPRs of the topologically protected edge states. More interestingly, the edge states are shown to have an evident "repulsion" effect on quantum walkers initiated from the lattice sites inside the bulk. Furthermore, we examine the role of nearest-neighbor interaction on the quantum walks of two identical fermions. Clear enhancement of the repulsion effect by strong interaction has been shown.

  18. Generalized Aubry-André-Harper model with p -wave superconducting pairing

    Science.gov (United States)

    Zeng, Qi-Bo; Chen, Shu; Lü, Rong

    2016-09-01

    We investigate a generalized Aubry-André-Harper (AAH) model with p -wave superconducting pairing. Both the hopping amplitudes between the nearest-neighboring lattice sites and the on-site potentials in this system are modulated by a cosine function with a periodicity of 1 /α . In the incommensurate case [α =(√{5 }-1 )/2 ] , due to the modulations on the hopping amplitudes, the critical region of this quasiperiodic system is significantly reduced and the system becomes easier to be turned from extended states to localized states. In the commensurate case (α =1 /2 ), we find that this model shows three different phases when we tune the system parameters: Su-Schrieffer-Heeger (SSH)-like trivial, SSH-like topological, and Kitaev-like topological phases. The phase diagrams and the topological quantum numbers for these phases are presented in this work. This generalized AAH model combined with superconducting pairing provides us with a useful test field for studying the phase transitions from extended states to Anderson localized states and the transitions between different topological phases.

  19. Chemical Profile and Antioxidant Activity of the Oil from Peony Seeds (Paeonia suffruticosa Andr.

    Directory of Open Access Journals (Sweden)

    Xin Yang

    2017-01-01

    Full Text Available Peony seed oil (PSO is a novel vegetable oil developed from the seeds of Paeonia suffruticosa Andr. The present study aimed to make an overall investigation on the chemical profile and antioxidant activities of PSO for reasonable development and utilization of this new resource food. Chemical analysis revealed that PSO was characterized by an uncommon high portion of α-linolenic acid (>38%, fairly low ratio of n-6 to n-3 polyunsaturated fatty acids (0.69, and much higher content of γ-tocopherol than various conventional seed oils. In vitro assay indicated that PSO is a more potent scavenger of free radicals than extra virgin olive oil. Moderate intake of PSO exhibited obvious protection against various oxidative damages such as tetrachloromethane-induced acute liver injury in mice and diet-induced hyperlipidemia in rats. The changes in the key indicators of oxidative injury and fatty acid composition in the liver caused by PSO administration were measured, and the results demonstrated that antioxidant properties of PSO are closely related to their characteristic chemical composition. Consequently, the present study provided new evidence for the health implications of PSO, which deserves further development for medical and nutritional use against oxidative damages that are associated with various diseases.

  20. Juan Andrés y el libro de "Viaje a Italia": las cartas familiares

    Directory of Open Access Journals (Sweden)

    Idoia Arbillaga

    2014-01-01

    Full Text Available El viaje a Italia se constituyó como género literario en el seno de la tradición del Grand tour. Esta tradición contribuyó a la elaboración de libros de viaje a Italia en las literaturas inglesa, francesa, alemana, norteamericana, rusa, holandesa, etc. A pesar de que la crítica europea negara la incorporación de la tradición española a este fenómeno cultural y literario, España sí posee una sólida tradición de libros de Viaje a Italia. Sin duda, su máximo ejemplo son las Cartas familiares escritas en el siglo XVIII por Juan Andrés. El artículo analiza la importancia retórica y temática de esta obra en el contexto de la tradición española y occidental.

  1. Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.

    Directory of Open Access Journals (Sweden)

    Douglas D Fang

    Full Text Available PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide mutations can help predict the antitumor activity of phosphatidylinositol-3-kinase (PI3K/mammalian target of rapamycin (mTOR pathway inhibitors in both preclinical and clinical settings. In light of the recent discovery of tumor-initiating cancer stem cells (CSCs in various tumor types, we developed an in vitro CSC model from xenograft tumors established in mice from a colorectal cancer patient tumor in which the CD133+/EpCAM+ population represented tumor-initiating cells. CD133+/EpCAM+ CSCs were enriched under stem cell culture conditions and formed 3-dimensional tumor spheroids. Tumor spheroid cells exhibited CSC properties, including the capability for differentiation and self-renewal, higher tumorigenic potential and chemo-resistance. Genetic analysis using an OncoCarta™ panel revealed a PIK3CA (H1047R mutation in these cells. Using a dual PI3K/mTOR inhibitor, PF-04691502, we then showed that blockage of the PI3K/mTOR pathway inhibited the in vitro proliferation of CSCs and in vivo xenograft tumor growth with manageable toxicity. Tumor growth inhibition in mice was accompanied by a significant reduction of phosphorylated Akt (pAKT (S473, a well-established surrogate biomarker of PI3K/mTOR signaling pathway inhibition. Collectively, our data suggest that PF-04691502 exhibits potent anticancer activity in colorectal cancer by targeting both PIK3CA (H1047R mutant CSCs and their derivatives. These results may assist in the clinical development of PF-04691502 for the treatment of a subpopulation of colorectal cancer patients with poor outcomes.

  2. O Ateísmo Francês Contemporâneo: uma comparação crítica entre Michel Onfray e André Comte-Sponville/Contemporary French Atheism: a Critical Comparison between Michel Onfray and André Comte-Sponville

    National Research Council Canada - National Science Library

    Agnaldo Cuoco Portugal

    2010-01-01

    Michel Onfray and André Comte-Sponville are the most famous representatives of philosophical contemporary French atheism, which is a continuation of a tradition begun in the 18th Century of irreligious denying...

  3. O Ateísmo Francês Contemporâneo: uma comparação crítica entre Michel Onfray e André Comte-Sponville/Contemporary French Atheism: a Critical Comparison between Michel Onfray and André Comte-Sponville

    National Research Council Canada - National Science Library

    Agnaldo Cuoco Portugal; Abraão Lincoln Ferreria Costa

    2010-01-01

    Michel Onfray and André Comte-Sponville are the most famous representatives of philosophical contemporary French atheism, which is a continuation of a tradition begun in the 18th Century of irreligious denying of the...

  4. Une « huile » végétale aux multiples usages dans la région du fleuve Sépik (Papouasie Nouvelle-Guinée)

    OpenAIRE

    Coiffier, Christian

    2008-01-01

    L’exsudat d’un arbre du genre Campnosperma est collecté dans une grande partie du bassin du fleuve Sépik. Cet exsudat constitue un liquide huileux utilisé localement pour de très nombreux usages rituels. Sa représentation locale comme substance vitale en fait un produit qui participe à divers types d’échanges. The exudation of trees, Campnosperma species, is gathered on a large part of the Sepik River Valley basin. This exultation is on oily liquid that is used locally for many rituals. Be...

  5. Postharvest Quality Of Tomato Fruits Cv. Andréa Treated With Ethylene [qualidade Pós-colheita De Frutos De Tomate Cv. Andréa Tratados Com Etileno

    OpenAIRE

    Andreuccetti C.; Ferreira M.D.; Moretti C.L.; Honorio S.L.

    2007-01-01

    Tomatoes are one of the most important vegetable crops grown in Brazil and treatments that facilitate ripening control are extremely desirable. The present work was carried out aiming to evaluate postharvest quality of roma-type tomatoes treated with ethylene. 'Andréa' tomatoes were harvested in commercial fields at the mature-green stage, were graded for size and color, and treated with ethylene (100 μL L-1) for 48 hours at 20°±1°C and relative humidity of 90±5%. The experiments were carried...

  6. Evaluation of horticultural traits and seed germination of Tacca chantrieri ‘André

    Directory of Open Access Journals (Sweden)

    Krisantini

    2017-06-01

    Full Text Available Tacca chantrieri André is a perennial plant belonging to the Taccaceae family. T. chantrieri is known as the ‘bat flower’ or ‘bat plant’ due to its unique black bracts that resemble bats. It has the potential to be commercialized as an indoor, flowering, ornamental plant due to its unique flower morphology and shade tolerance. The distribution of T. chantrieri in its natural habitat has contracted due to land clearing and habitat destruction to the extent that it is now very hard to find in its traditional natural environment. The objectives of this study were to evaluate the morphological characteristics of T. chantrieri, to evaluate seed germination in vivo and in vitro, and in vitro culture of the plant using standard Murashige and Skoog (MS media. Only 10% of the seeds germinated in 22 wk. An evaluation of the non-germinated seed showed that 42% of the seeds did not have embryos. In vitro culture using the standard MS media resulted in 3–7 new shoots growing from the basal parts of the seedlings after 22 wk, and each shoot further developed 4–7 shoots following transfer to MS media supplemented with indole acetic acid (IAA at 0.25–0.75 mg/L and N6-benzyladenine (BA at 1–2 mg/L. These results indicate that even though propagation protocols should be further developed, in vitro propagation using standard MS media supplemented with combinations of IAA and BA provides a more effective way to propagate T. chantrieri when compared to the conventional propagation techniques. This information will be useful for introducing T. chantrieri to the new ornamental plant market and to conservation efforts for this species.

  7. Estudio de la frecuencia de hemoglobinopatías en las islas de San Andrés y Providencia, Colombia

    Directory of Open Access Journals (Sweden)

    María del Pilar Bernal

    1995-03-01

    Full Text Available Se realizó un estudio destinado a determinar la frecuencia de hemoglobinopatías en las islas caribeñas de San Andrés y Providencia, en 544 individos individuos: 443 de San Andrés y 101 de Providencia. La frecuencia en San Andrés fue del 12,8% y en Providencia 20,8%; las hemoglobinopatías más frecuentes fueron: el rasgo falciforme, la hemoglobina C y la beta-talasemia. Los datos indican, que las hemoglobinopatías en esta región del país como problema de salud pública, tienen importancia y nos dan información sobre el origen geográfico de la población.

  8. A Transnational World Fractured but Not Forgotten: British West Indian Migration to the Colombian Islands of San Andrés and Providence

    Directory of Open Access Journals (Sweden)

    Sharika Crawford

    2011-06-01

    Full Text Available This article examines British West Indian migration to the Colombian archipelago of San Andrés and Providence in the late nineteenth to early twentieth century. While the United Fruit plantations, Panama Canal, oil fields in Venezuela, and railroad projects in Central America generated a strong demand for a large West Indian workforce, no such development took place on San Andrés and Providence. As a result, the profile of West Indian migration looks different than to the Spanish-speaking circum-Caribbean, with more professionals and merchants and fewer unskilled laborers. In the absence of mass migration, there was less hostility toward West Indian newcomers to San Andrés and Providence islands.

  9. Effective lifetime measurements in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$, $B^{0} \\rightarrow K^{+}\\pi^{-}$ and $B_{s}^{0} \\rightarrow \\pi^{+}K^{-}$ decays

    CERN Document Server

    INSPIRE-00258707; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves Jr, A.A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J.E.; Appleby, R.B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J.J.; Badalov, A.; Balagura, V.; Baldini, W.; Barlow, R.J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Bauer, Th.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjornstad, P.M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Borsato, M.; Bowcock, T.J.V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N.H.; Brown, H.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Garcia, L.Castillo; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Cheung, S.F.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P.E.L.; Clemencic, M.; Cliff, H.V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G.A.; Craik, D.C.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P.N.Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; de Miranda, J.M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Deleage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suarez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Esen, S.; Evans, T.; Falabella, A.; Farber, C.; Farinelli, C.; Farley, N.; Farry, S.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gavardi, L.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani', S.; Gibson, V.; Giubega, L.; Gligorov, V.V.; Gobel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Gotti, C.; Grabalosa Gandara, M.; Graciani Diaz, R.; Granado Cardoso, L.A.; Grauges, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grunberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S.C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S.T.; Harrison, J.; Hartmann, T.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J.A.; van Herwijnen, E.; Hess, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hunt, P.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jaton, P.; Jawahery, A.; Jezabek, M.; Jing, F.; John, M.; Johnson, D.; Jones, C.R.; Joram, C.; Jost, B.; Jurik, N.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T.M.; Kelsey, M.; Kenyon, I.R.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R.F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V.N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R.W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.P.; Lefevre, R.; Leflat, A.; Lefrancois, J.; Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Liu, G.; Lohn, S.; Longstaff, I.; Lopes, J.H.; Lopez-March, N.; Lowdon, P.; Lu, H.; Lucchesi, D.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Machikhiliyan, I.V.; Maciuc, F.; Maev, O.; Malde, S.; Manca, G.; Mancinelli, G.; Manzali, M.; Maratas, J.; Marchand, J.F.; Marconi, U.; Benito, C.Marin; Marino, P.; Marki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martin Sanchez, A.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; McSkelly, B.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D.A.; Minard, M.N.; Moggi, N.; Molina Rodriguez, J.; Monteil, S.; Moran, D.; Morandin, M.; Morawski, P.; Morda, A.; Morello, M.J.; Moron, J.; Mountain, R.; Muheim, F.; Muller, K.; Muresan, R.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A.D.; Nguyen, T.D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, G.; Orlandea, M.; Otalora Goicochea, J.M.; Owen, P.; Oyanguren, A.; Pal, B.K.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C.J.; Passaleva, G.; Patel, G.D.; Patel, M.; Patrignani, C.; Pazos Alvarez, A.; Pearce, A.; Pellegrino, A.; Pepe Altarelli, M.; Perazzini, S.; Perez Trigo, E.; Perret, P.; Perrin-Terrin, M.; Pescatore, L.; Pesen, E.; Petridis, K.; Petrolini, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilar, T.; Pinci, D.; Pistone, A.; Playfer, S.; Plo Casasus, M.; Polci, F.; Poluektov, A.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Rachwal, B.; Rademacker, J.H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M.S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Reichert, S.; Reid, M.M.; dos Reis, A.C.; Ricciardi, S.; Richards, A.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Roa Romero, D.A.; Robbe, P.; Rodrigues, A.B.; Rodrigues, E.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Vidal, A.Romero; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruffini, F.; Ruiz, H.; Valls, P.Ruiz; Sabatino, G.; Saborido Silva, J.J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Coutinho, R.Silva; Simi, G.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, N.A.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M.D.; Soler, F.J.P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spinella, F.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Subbiah, V.K.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szilard, D.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M.T.; Tresch, M.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Garcia, M.Ubeda; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vazquez Sierra, C.; Vecchi, S.; Velthuis, J.J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voss, C.; Voss, H.; de Vries, J.A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D.R.; Watson, N.K.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiedner, D.; Wilkinson, G.; Williams, M.P.; Williams, M.; Wilson, F.F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S.A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Xu, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W.C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zvyagin, A.

    2014-01-01

    Measurements of the effective lifetimes in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$, $B^{0} \\rightarrow K^{+}\\pi^{-}$ and $B_{s}^{0} \\rightarrow \\pi^{+}K^{-}$ decays are presented using $1.0~\\mathrm{fb^{-1}}$ of $pp$ collision data collected at a centre-of-mass energy of 7 TeV by the LHCb experiment. The analysis uses a data-driven approach to correct for the decay time acceptance. The measured effective lifetimes are $\\tau_{B_{s}^{0} \\rightarrow K^{+}K^{-}}$ = $1.407~\\pm~0.016~\\pm~0.007~\\mathrm{ps}$, $\\tau_{B^{0} \\rightarrow K^{+}\\pi^{-}}$ = $1.524~\\pm~0.011~\\pm~0.004~\\mathrm{ps}$, $\\tau_{B_{s}^{0} \\rightarrow \\pi^{+}K^{-}}$ = $1.60~\\pm~0.06~\\pm~0.01~\\mathrm{ps}$. This is the most precise determination to date of the effective lifetime in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$ decay and provides constraints on contributions from physics beyond the Standard Model to the $B_{s}^{0}$ mixing phase and the width difference $\\Delta\\Gamma_{s}$.

  10. Representar, practicar y repensar el Patrimonio Cultural: el caso de San Andrés Calpan, Puebla

    OpenAIRE

    Arellano Espinosa, Andrea

    2015-01-01

    El presente texto es el resultado de una investigación antropológica sobre las representaciones sociales y las prácticas socioculturales en torno a un sitio patrimonio cultural: el ex convento de San Andrés Calpan, Puebla, uno de los primeros monasterios franciscanos edificados en México. Desde 1994 forma parte de la designación Primeros monasterios del siglo XVI en las laderas del Popocatépetl de la lista del Patrimonio de la Humanidad de UNESCO. Cuatro capillas posas, las más importantes po...

  11. Andrés Neuman y la traducción como vehículo de pensamiento

    Directory of Open Access Journals (Sweden)

    Katiuscia Darici

    2014-12-01

    Full Text Available El presente artículo se propone analizar el asunto de la traducción cultural y lingüística en la obra del escritor Andrés Neuman (Buenos Aires, 1977, cuya biografía se ve afectada por el traslado de Latinoamérica a España en una edad temprana de su vida. Se verá cómo la presencia predominante del problema de la traducción en una selección importante de sus novelas y cuentos se debe no sólo a razones biográficas, sino también a una cultura, como la actual, caracterizada por la transculturalidad y las migraciones. The present article analyses the importance of cultural and linguistic translation in Andrés Neuman’s works (Buenos Aires, 1977, whose biography is affected by his move from Latin America to Spain at an early age. Translation as a problematic issue in an important selection of novels and short stories by the Argentinian-Spanish novelist will be considered in light of nowadays culture, characterized by transculturalism and migration flows.

  12. Youth map of the city of Santo André, Southeastern Brazil: an instrument to read social inequalities.

    Science.gov (United States)

    Yonekura, Tatiana; Soares, Cássia Baldini; Minuci, Elaine Garcia; Campos, Célia Maria Sivalli; Trapé, Carla Andrea

    2010-02-01

    To analyze social inequalities in young adults living in an urban area by mapping sociodemographic and economic data. Using data from the 2000 Demographic Census, 57 sociodemographic and economic variables of young adults aged from 15 to 24 years, living in the city of Santo André, Southeastern Brazil, were distributed among 43 areas of statistical data, corresponding to a division of the region into smaller districts. Data from the year 2000 were collected from the Santo André City Hall Department of Socioeconomic Indicators. Using factorial analysis, 13 variables were grouped in two factors - working conditions and life conditions, which distinguished areas that were similar to one another statistically. Cluster analysis of areas was performed, resulting in four social groups. The area that concentrated young adults with higher access to wealth was classified as central and that including individuals with lower access to wealth was classified as peripheral. Two intermediate areas could be identified, one closer to the highest access to wealth ('almost central') and another close to the lowest access to wealth ('almost peripheral'). Discriminating variables were associated with work, migration, level of education, fertility, adolescent's position in the household, presence of spouse or partner, living conditions and assets owned. Differences among social groups revealed important inequalities among young adults who live, study and/or work in the city, which will contribute to the planning of public social policies aimed at these groups.

  13. Kjøring med mistanke om påvirkning av andre rusmidler enn alkohol

    Directory of Open Access Journals (Sweden)

    Asbjørg S. Christophersen

    2009-10-01

    Full Text Available  SAMMENDRAGStatens rettstoksikologiske institutt har i løpet av de siste år registrert en stor økning av prøver fra bilføreremistenkt for kjøring under påvirkning av andre rusmidler enn alkohol. Antall positive saker økte 42% fra1994 til 1995. De hyppigste påviste stoffer er tetrahydrocannabinol, amfetamin, benzodiazepiner og opiater(morfin/kodein. Bruk av tyngre narkotiske stoffer har blitt mer vanlig i trafikksammenheng og antall positivetilfeller har økt betydelig mer enn totalt antall saker. Fra 1994 til 1995 økte antall positive amfetaminprøvermed 75% (fra 533 til 937 og antall positive prøver som følge av heroininntak økte med 87% (fra 92 til 172.Bruk av flere stoffer samtidig er vanlig, over 60 % av sakene i 1995 var positive på mer enn ett stoff, alkoholikke medregnet. De fleste tilfeller var representert av menn i alderen 25-32 år (37%. Kvinner var representerti ca. 11% av sakene.Christophersen AS, Skurtveit S, Mørland J. Drivers suspected to drive under the influence of drugs otherthan alcohol. Nor J Epidemiol 1996; 6 (1: 45-48.ENGLISH SUMMARYThe National Institute of Forensic Toxicology has registered a large increase in the number of samples fromdrivers suspected to drive under influence of drugs other than alcohol. The number of drug positive casesincreased 42% from 1994 to 1995. The most frequent drugs detected are tetrahydrocannabinol, amphetamine,benzodiazepines and opiates (morphine/codeine. The frequency of hard narcotic drug use has increased morethan the total number of cases. From 1994 to 1995, the number of amphetamine positive samples increased75% (from 533 to 937 and the number of samples positive due to heroin use (detection of the metabolite 6-monoacetylmorphine in urine increased 87%. Multi-drug use is common and more than one drug wasdetected in more than 60% of the cases from 1995, alcohol not included. Most of the cases were representedby men 25-32 years old (37%. Women were represented in about

  14. Identification of E545k mutation in plasma from a PIK3CA wild-type metastatic breast cancer patient by array-based digital polymerase chain reaction: Circulating-free DNA a powerful tool for biomarker testing in advance disease.

    Science.gov (United States)

    Romero, Atocha; Acosta-Eyzaguirre, Daniel; Sanz, Julián; Moreno, Fernando; Serrano, Gloria; Díaz-Rubio, Eduardo; Caldés, Trinidad; Garcia-Saenz, José Á

    2015-12-01

    PIK3CA gene is frequently mutated in patients with breast cancer and it has been the focus of intense research. Inhibitors of PI3K pathway are being evaluated in ongoing clinical trials but the impact of PIKC3A mutation status on tumor response is yet uncertain. In the metastatic setting, several studies are evaluating the predictive value of PIK3CA mutations. However, results could be biased by biopsy localization. Digital polymerase chain reaction is a new technology that enables detection and quantification of cancer DNA molecules from peripheral blood and can potentially overcome such situation. As a proof of the concept, we present the case of a metastatic patient with a PIK3CA wild-type primary tumor in which the PIK3CA E545K mutation was identified in both the circulating-free DNA obtained from a peripheral blood sample and in the formalin-fixed, paraffin-embedded liver metastasis. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Evaluation of a Voluntary Tutoring Program in Chemistry, Physics and Mathematics for First-Year Undergraduates at Universidad Andres Bello, Chile

    Science.gov (United States)

    Jiménez, Verónica A.; Acuña, Fabiola C.; Quiero, Felipe J.; López, Margarita; Zahn, Carmen I.

    2015-01-01

    This work describes the preliminary results of a tutoring program that provides personalized academic assistance to first-year undergraduates enrolled in introductory chemistry, physics and mathematics courses at Universidad Andres Bello (UNAB), in Concepción, Chile. Intervened courses have historically large enrolments, diverse student population…

  16. XII Avatud Ühiskonna Foorumi arutlusring "Euroopa hiilgus ja viletsus - Euroopa Liit 50. Kuidas edasi?" / Toomas Hendrik Ilves, Mark Leonard, Ivan Krastev ; intervjueerinud Andres Kasekamp

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    Pärnus diskuteerisid 10. oktoobril 2007 Euroopa tuleviku teemadel president Toomas Hendrik Ilves, Euroopa Välissuhete Nõukogu tegevjuht Mark Leonard ja Sofias paikneva Liberaalstrateegiate Keskuse juht Ivan Krastev. Vestluse moderaator oli Eesti Välispoliitika Instituudi direktor, Avatud Eesti Fondi nõukogu esimees Andres Kasekamp

  17. Mida arvate koolikohustusliku ea tõstmisest 18. eluaastani? / Eero Järvekülg, Boris Goldman, Rein Eglon, Andres Ammas...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Carl Robert Jakobsoni nim. gümnaasiumi direktor Eero Järvekülg, Tartu linnavalitsuse haridusosakonna juhataja Boris Goldman, Pärnu Koidula gümnaasiumi direktor Rein Eglon, Haapsalu gümnaasiumi direktor Andres Ammas ja Väike-Maarja gümnaasiumi ja õppekeskuse direktor Raili Sirgmets

  18. APPLICATION OF WATER-JET HORIZONTAL DRILLING TECHNOLOGY TO DRILL AND ACIDIZE HORIZONTAL DRAIN HOLES, TEDBIT (SAN ANDRES) FIELD, GAINES COUNTY, TEXAS

    Energy Technology Data Exchange (ETDEWEB)

    Michael W. Rose

    2005-09-22

    The San Andres Formation is one of the major hydrocarbon-producing units in the Permian Basin, with multiple reservoirs contained within the dolomitized subtidal portions of upward shoaling carbonate shelf cycles. The test well is located in Tedbit (San Andres) Field in northeastern Gaines County, Texas, in an area of scattered San Andres production associated with local structural highs. Selected on the basis of geological and historical data, the Oil and Gas Properties Wood No. 1 well is considered to be typical of a large number of San Andres stripper wells in the Permian Basin. Thus, successful completion of horizontal drain holes in this well would demonstrate a widely applicable enhanced recovery technology. Water-jet horizontal drilling is an emerging technology with the potential to provide significant economic benefits in marginal wells. Forecast benefits include lower recompletion costs and improved hydrocarbon recoveries. The technology utilizes water under high pressure, conveyed through small-diameter coiled tubing, to jet horizontal drain holes into producing formations. Testing of this technology was conducted with inconclusive results. Paraffin sludge and mechanical problems were encountered in the wellbore, initially preventing the water-jet tool from reaching the kick-off point. After correcting these problems and attempting to cut a casing window with the water-jet milling assembly, lateral jetting was attempted without success.

  19. Process optimisation of microwave-assisted extraction of peony ( Paeonia suffruticosa Andr .) seed oil using hexane-ethanol mixture and its characterisation

    Science.gov (United States)

    Xiaoli Sun; Wengang Li; Jian Li; Yuangang Zu; Chung-Yun Hse; Jiulong Xie; Xiuhua Zhao

    2016-01-01

    Ethanol and hexane mixture agent microwave-assisted extraction (MAE) method was conducted to extract peony (Paeonia suffruticosa Andr.) seed oil (PSO). The aim of the study was to optimise the extraction for both yield and energy consumption in mixture agent MAE. The highest oil yield (34.49%) and lowest unit energy consumption (14 125.4 J g

  20. Noorsootöö Keskusel täitub kümnes tegevusaasta / Edgar Schlümmer ; kommenteerinud Irma Toodo, Ene Raid, Andres Lokk

    Index Scriptorium Estoniae

    Schlümmer, Edgar

    2009-01-01

    Eesti Noorsootöö Keskus (ENTK)tähistab kümnendat sünnipäeva. ENTK rolli tänapäeva noorsootöös kommenteerivad endine ENTK töötaja Irma Toodo ja praegused töötajad Ene Raid ning Andres Lokk

  1. Parálisis facial periférica en una pintura de Goya: el retrato de D. Andrés del Peral

    OpenAIRE

    Julio Montes Santiago

    2017-01-01

    En la sala 39 de la National Gallery de Londres, entre el retrato de la bellísima Dña. Isabel de Porcel -vestida de maja-,y del altivo Duque de Wellington —cargado de condecoraciones—, nos observa, con el rostro algo sombrío, D. Andrés del Peral.

  2. Tracing the development of contemporary park-city relationships : Parc de La Villette and Parc André Citroën (paper + presentation)

    NARCIS (Netherlands)

    Van der Velde, J.R.T.

    2012-01-01

    Since the late post--?war period the relationship between park and city has significantly altered. Parks established between 1980 and 2000 in Paris --? in particular Parc de La Villette and Parc André Citroën – exemplify developments in park design and the park--?city relationship in this period and

  3. Koerajuhi amet lisab tavatööle vürtsi / Rainer Lang, Andres Vesselov, Rainis Oper ; interv. Tanel Saarmann

    Index Scriptorium Estoniae

    Lang, Rainer

    2008-01-01

    Koerajuhid piirivalve-seersant Rainer Lang Saatsest, piirivalve-veebel Rainis Oper Värskast ning Saatse kordoni ülem piirivalve-kapten Andres Vesselov räägivad koerajuhiks saamisest ning teenistuskoerte koolitamisest. Lisa: Kagu PVP teenistuskoerad; Osalemine võistlustel 2008

  4. Forekomst av alkohol og andre rusmidler i blodprøver fra førere involvert i trafikkulykker

    Directory of Open Access Journals (Sweden)

    Anders Bjørneboe m.fl

    2009-10-01

    Full Text Available  SAMMENDRAGBilkjøring stiller store krav til førernes sansing, oppmerksomhet, informasjonsbearbeiding og evne til åreagere. Førere som er under innflytelse av sentralnervøst aktive stoffer, vil derfor være en potensiell fare itrafikken. I perioden 1.8–31.12. 1993 identifiserte Statens rettstoksikologiske institutt (SRI 394 ulykkesføreresom politiet hadde rekvirert analyser av med hensyn på narkotiske stoff/sentralnervøst aktive medikamenter(andre rusmidler og/eller alkohol. Blodprøver fra disse førerne ble analysert med hensyn på alkohol og etutvidet repertoar av andre rusmidler ved SRI. Da polititjenestemenn og medtrafikanter ofte ikke vil oppdagepåvirkning av andre rusmidler enn alkohol, dels pga. manglende alkohollukt, vil andre rusmidler som ulykkesårsakvære noe underrepresentert i dette materialet sammenliknet med alkohol. Hos 299 av ulykkesførerneble det påvist alkohol og/eller andre rusmidler. 44 førere hadde tatt inn både alkohol og andre rusmidler, mensalkohol og andre rusmidler ble påvist alene i henholdsvis 204 og 51 saker. Totalt ble benzodiazepiner,cannabis, opiater og amfetamin påvist i henholdsvis 54, 30, 17 og 16 saker. Av de 95 som hadde tatt inn andrerusmidler, hadde 34 tatt inn mer enn ett rusmiddel (alkohol ikke medregnet og i 72 av tilfellene ble analysefunnenevurdert (AB og JM til sannsynligvis å ha gitt sentralnervøs påvirkning. Risikoøkningen for trafikkulykkeved nylig bruk av cannabisstoffer og diazepam i høydose ble estimert til å kunne tilsvare en blodalkoholkonsentrasjonpå 1-1,5 promille. Alkohol er det rusmiddel som oftest påvises hos ulykkesførere, menforekomsten av benzodiazepiner, cannabis og amfetamin er såvidt høy blant ulykkesførere at disse stoffenemå anses å være et alvorlig trafikksikkerhetsproblem.Bjørneboe A, Beylich K-M, Christophersen AS, Fosser S, Glad A, Mørland J.Prevalence of alcohol and other intoxicants in blood samples from drivers involved in road

  5. Estimate the potential production of electricity: a case study of the sanitary landfill of Santo Andre, Sao Paulo, Brazil; Estimativa do potencial de producao de eletricidade: estudo de caso do aterro sanitario de Santo Andre, Sao Paulo, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Elissando Rocha da; Moreira, Joao M. L.; Candiani, Giovano [Instituto Federal de Educacao, Ciencia e Tecnologia de Sao Paulo (IFSP), SP (Brazil)

    2010-07-01

    The recovery of the biogas generated from sanitary landfills, associated to its energetic use has been widely discussed. Thus, this paper aims to estimate the potential production of electric energy from sanitary landfill Santo Andre-SP. The biogas production was estimated using the rate of deposition of solid wastes in the landfill, using some mathematical models with parameters suggested by two models: LanGEM-USEPA (conventional landfill) and Word Bank. These results indicate that the potential of biogas production will be approximately 11 x 10{sup 6} Kg of methane/year in 2017 and production of electric energy in that year will be approximately 32,000 MWh, considering an of 75% over collection of biogas. (author)

  6. Review: André du Pisani, Reinhart Kössler, and William A. Lindeke (eds., The Long Aftermath of War: Reconciliation and Transition in Namibia (2010 Buchbesprechung: André du Pisani, Reinhart Kössler und William A. Lindeke (Hrsg., The Long Aftermath of War: Reconciliation and Transition in Namibia (2010

    Directory of Open Access Journals (Sweden)

    Dag Henrichsen

    2011-01-01

    Full Text Available Review of the edited volume: André du Pisani, Reinhart Kössler, and William A. Lindeke (eds., The Long Aftermath of War: Reconciliation and Transition in Namibia (Freiburger Beiträge zu Entwicklung und Politik, 37, Freiburg: Arnold-Bergstraesser-Institut, 2010, ISBN 978-3-928597-55-5, 437 pp.Besprechung des Sammelbandes: André du Pisani, Reinhart Kössler und William A. Lindeke (Hrsg., The Long Aftermath of War: Reconciliation and Transition in Namibia (Freiburger Beiträge zu Entwicklung und Politik, 37, Freiburg: Arnold-Bergstraesser-Institut, 2010, ISBN 978-3-928597-55-5, 437 Seiten

  7. Phase diagram of a generalized off-diagonal Aubry–André model with p-wave pairing

    Science.gov (United States)

    Liu, Tong; Wang, Pei; Chen, Shu; Xianlong, Gao

    2018-01-01

    Off-diagonal Aubry–André (AA) model has recently attracted a great deal of attention as they provide condensed matter realization of topological phases. We numerically study a generalized off-diagonal AA model with p-wave superfluid pairing in the presence of both commensurate and incommensurate hopping modulations. The phase diagram as functions of the modulation strength of incommensurate hopping and the strength of the p-wave pairing is obtained by using the multifractal analysis. We show that with the appearance of the p-wave pairing, the system exhibits mobility-edge phases and critical phases with various number of topologically-protected zero-energy modes. Predicted topological nature of these exotic phases can be realized in a cold atomic system of incommensurate bichromatic optical lattice with induced p-wave superfluid pairing by using a Raman laser in proximity to a molecular Bose–Einstein condensation.

  8. [Use and attitudes about drugs among nursing students at the Universidad Mayor de San Andrés].

    Science.gov (United States)

    Flores, Iblin Elizabeth Enriquez; Luis, Margarita Antonia Villar

    2004-01-01

    This study presents the results of a research that examined the use and attitudes about alcohol, tobacco, coca leaves, tranquilizers and amphetamines among nursing students at the Universidad Mayor de San Andrés who had not used these substances over the last 12 months. Data were collected in August 2002 by means of a self-administered and distributed questionnaire, which guaranteed anonymity. The following results were obtained: Attitudes related to drugs approve of coca leaf and tranquilizer use and disapprove of cocaine. Personal use of drugs during the last 12 months corresponds to: daily use of coca leaves, alcohol less than once per week and tobacco every day. The main reason for using these drugs is related to religious practice; the students' first contact with drugs occurs through family members and (girl or boy) friends.

  9. Thermal comfort in twentieth-century architectural heritage: Two houses of Le Corbusier and André Wogenscky

    Directory of Open Access Journals (Sweden)

    Ignacio Requena-Ruiz

    2016-06-01

    This article aims to develop a balanced understanding of the approach of Modernist architecture to climate, indoor atmospheres and inhabitants׳ thermal comfort. To do so, we complement the quantitative approach of environmental assessment methods with the qualitative angle of the history of sensory and architecture. The goal is to understand the environmental performance of architecture for dealing nowadays with thermal comfort issues while respecting its cultural and historical values. Two modernist houses have been selected as case studies: the Villa Curutchet of the master Le Corbusier and the Villa Chupin of his disciple André Wogenscky. As a result, the article reveals potentialities and constraints in terms of thermal comfort when working with Modern Architecture.

  10. How Two Sides of the Atlantic Contributed to Understanding of the Global Oceans: Charles Yentsch and Andre Morel

    Science.gov (United States)

    Acker, James G.

    2013-01-01

    In a few short days in September of this year, the ocean color/ocean optics community lost two of the founding members of its Hall of FameCharles Yentsch and Andre Morel. Yentsch passed away at the age of 85 on September 19, and Morel passed away on September 23 at the age of 79. It might sound clich to say that someone was instrumental to the advance of science in a particular field, but in the case of Yentsch and Morel and ocean color instrumentation, such an assessment would likely be accurate. Each mans career complimented that of the other Yentsch was one of the first to make measurements of the light field of the ocean from altitude and to advocate an instrument in space that could observe the spectrum of ocean radiance Morels theoretical underpinnings established a firm foundation for the measurements such an instrument could make, allowing their successful interpretation.

  11. André Pichot, Aux origines des théories raciales. De la Bible à Darwin

    Directory of Open Access Journals (Sweden)

    Anthony Feneuil

    2010-07-01

    Full Text Available « Le darwinisme n’est pas une théorie scientifique qui a connu maintes dérives idéologiques, c’est une idéologie à qui la génétique a fini par donner un aspect à peu près scientifique » (p. 299. Telle est la thèse qui conduit André Pichot, dans son dernier livre, à opérer un bouleversement des catégories habituelles de pensée : Darwin n’est plus le champion de la vision scientifique du monde en lutte contre la conception obscurantiste du créationnisme et du finalisme religieux, mais l’une de...

  12. Géographie fractale : fractals auto-similaire et auto-affine, André DAUPHINÉ, 2011

    Directory of Open Access Journals (Sweden)

    Philippe Martin

    2011-11-01

    Full Text Available Dans une collection dirigée par P. DUMOLARD chez Hermès – Science, André DAUPHINÉ nous livre une nouvelle étape de sa réflexion dans un ouvrage qui oscille entre un manuel et un essai, tant l'auteur y affirme avec force ses convictions de géographe théoricien et quantitativiste qui souhaite, à juste titre, tirer la géographie vers plus de scientificité.Divisé en neuf chapitres assez courts de lecture relativement aisée, car l'auteur ne peut éviter tout formalisme, cet ouvrage tente d'être un ...

  13. Dynamic changes in enzyme activities and phenolic content during in vitro rooting of tree peony (Paeonia suffruticosa Andr. plantlets

    Directory of Open Access Journals (Sweden)

    Songlin He

    2011-07-01

    Full Text Available The dynamic changes of phenolic content and peroxidase (POD, polyphenol oxidase (PPO, indole-3-acetic acid oxidase (IAAO and phenylalanine ammonia lyase (PAL activities were assessed during the in vitro rooting process of three cultivars of tree peony (Paeonia suffruticosa Andr.. These changes in enzyme-related activity and phenolic content__observed at the level of the whole plant__differed during the first 20 days of the rooting process in easy-to-root ‘Feng Dan Bai’ cultivar and difficult-to-root ‘Wu Long Peng Sheng’ and ‘Tai Ping Hong’ cultivars, and in most cases they were actually opposite. The ease with which ‘Feng Dan Bai’ was able to root was closely related to the activity of all four enzymes (POD, PPO, IAAO, PAL as well as to the phenolic content.

  14. Cadmium and lead levels along the estuarine ecosystem of Tigre River-San Andres Lagoon, Tamaulipas, Mexico.

    Science.gov (United States)

    Vázquez-Sauceda, María de la Luz; Pérez-Castañeda, Roberto; Sánchez-Martínez, Jesús Genaro; Aguirre-Guzmán, Gabriel

    2012-10-01

    Cadmium and lead levels were evaluated in water and sediment along the estuarine ecosystem of Tigre River-San Andres Lagoon (Gulf of Mexico) during September to December 2009. Significant highest metal concentration in water (0.45 mg L(-1) Cd and 3.94 mg L(-1) Pb) and sediment (2.83 mg kg(-1) Cd and 6.61 mg kg(-1) Pb) were found at the mouth of the Tigre River, where the fishing town of El Moron is located. Cadmium levels in sediment were above limits associated with adverse biological effects on aquatic fauna, so negative impacts on natural populations of aquatic organisms would be expected to occur. This in turn could affect the fishery resources inhabiting this ecosystem.

  15. Estudios sobre los uredinales del archipiélago de San Andrés y providencia, Colombia.

    Directory of Open Access Journals (Sweden)

    Pardo Cardona Víctor Manuel

    2003-12-01

    Full Text Available Doce especies de Uredinales fueron colectados en las islas de San Andrés y Providencia durante una visita de colección efectuada en el mes de Octubre de 2002. Los hospederos fueron determinados y herborizados y a partir de ellos se elaboraron micropreparados que contenían los soros con las esporas de los hongos, los cuales fueron observados y estudiados al microscopio. Puccinia cyperi-tagetiformis Kem es nuevo registro para Colombia; se registró a Brachiaria distachya (L Stapf como nuevo hospedante de Uromyces clignyi Patouillard & Hariot y a Cyperus rotundus L como nuevo hospedante para P. cyperi-tagetiformis. Las demos especies colectados han sido registradas en el neotrópico sobre hospedantes previamente conocidos.

  16. Simulating and studying the topological properties of generalized commensurate Aubry–André–Harper model with microresonator array

    Science.gov (United States)

    Cao, Ji; Xing, Yan; Qi, Lu; Wang, Dong-Yang; Bai, Cheng-Hua; Zhu, Ai-Dong; Zhang, Shou; Wang, Hong-Fu

    2018-01-01

    The Aubry–André or Harper (AAH) model has been studied extensively, against the background of quantum localization. Here we present a conceptually simple and experimentally feasible scheme to simulate a generalized 1D commensurate AAH model based on an array of whispering-gallery-mode microtoroid resonators connected via waveguides. We show that the commensurate off-diagonal AAH model exhibits topological zero-energy edge modes and topologically nontrivial properties. Compared with traditional commensurate AAH model, our model introduces the periodically modulated next-nearest-neighbor hopping term, and we find that the family of the model system can be made to exhibit topologically nontrivial properties by appropriate modulation of parameters.

  17. Realization of high-Q/V photonic crystal cavities defined by an effective Aubry-André-Harper bichromatic potential

    Science.gov (United States)

    Simbula, A.; Schatzl, M.; Zagaglia, L.; Alpeggiani, F.; Andreani, L. C.; Schäffler, F.; Fromherz, T.; Galli, M.; Gerace, D.

    2017-05-01

    We report on the realization of high-Q/V photonic crystal cavities in thin silicon membranes, with resonances around 1.55 μm wavelength. The cavity designs are based on a recently proposed photonic crystal implementation of the Aubry-André-Harper bichromatic potential, defined from the superposition of two one-dimensional lattices with a non-integer ratio between their periodicity constants. In photonic crystal nanocavities, this confinement mechanism is such that optimized figures of merit can be straightforwardly achieved, in particular an ultra-high-Q factor and diffraction-limited mode volume. Several silicon membrane photonic crystal nanocavities have been realized with measured Q-factors in the 1 × 106 range, as evidenced by resonant scattering. The generality of the proposed designs and their easy implementation and scalability make these results particularly interesting for realizing highly performing photonic nanocavities on different material platforms and operational wavelengths.

  18. PT -breaking threshold in spatially asymmetric Aubry-André and Harper models: Hidden symmetry and topological states

    Science.gov (United States)

    Harter, Andrew K.; Lee, Tony E.; Joglekar, Yogesh N.

    2016-06-01

    Aubry-André-Harper lattice models, characterized by a reflection-asymmetric sinusoidally varying nearest-neighbor tunneling profile, are well known for their topological properties. We consider the fate of such models in the presence of balanced gain and loss potentials ±i γ located at reflection-symmetric sites. We predict that these models have a finite PT -breaking threshold only for specific locations of the gain-loss potential and uncover a hidden symmetry that is instrumental to the finite threshold strength. We also show that the topological edge states remain robust in the PT -symmetry-broken phase. Our predictions substantially broaden the possible experimental realizations of a PT -symmetric system.

  19. Effect of loss on the topological features of dimer chains described by the extended Aubry-André-Harper model

    Science.gov (United States)

    Zhao, X. L.; Shi, Z. C.; Yu, C. S.; Yi, X. X.

    2017-04-01

    By introducing loss to one sublattice of dimer chains described by the extended Aubry-André or Harper (AAH) model, we study the topological features including the winding number, the edge states, Chern number, and spectrum of the chain. We find that the parameter region for the system to have real band-gap closing is increased due to the loss, and the average displacement of the single excitation can indicate the topological features of the chain in the presence of loss on one sublattice. The robustness of the zero energy eigenstate against four kinds of disorders are examined. A feasible experimental apparatus based on coupled waveguides to observe the predictions of this work is proposed.

  20. ANGIOSPERM FLAG SPECIES FOR MANGROVE CONSERVATION IN San AndrÉs Island (colombia ARE HIGHLY VULNERABLE AND locally rare

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    Gloria Andrea Murcia

    2016-01-01

    Full Text Available El concepto de especies bandera ha sido empleado en proyectos de conservación por 50 años. Se proponen aquí cinco especies nativas de la Isla de San Andrés como especies bandera para la conservación de los pocos remanentes de manglar en esta Isla: Bontia daphnoides (Myoporaceae, Canella winterana (Canellaceae, Eustoma exaltatum (Gentianaceae, Rhabdadenia biflora (Apocynaceae y Selenicereus grandiflorus (Cactaceae. Cuatro de estas especies son documentadas aquí por primera vez para el Archipiélago, y tres representan los primeros reportes para la Flora de Colombia, dos de ellos (Canellaceae y Myoporaceae a nivel de familia.

  1. El posicionamiento de Sigmund Freud ante el Surrealismo a través de la correspondencia con André Breton

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    Javier Cuevas del Barrio

    2013-11-01

    Full Text Available El objetivo de este artículo es explicar el posicionamiento de Sigmund Freud respecto al Surrealismo. Es conocido el interés de Andre Breton para que el padre del psicoanálisis abrazara la causa surrealista. Sin embargo, el psicoanalista vienés, a pesar de los números intentos, siempre se mantuvo al margen del grupo surrealista. En este artículo intentamos explicar las posibles razones de dicha posición.The aim of this article is to explain the position of Sigmund Freud regarding Surrealism. Andre Breton’s interest in the father of psychoanalysis is well known. However, Freud always stayed away from the Surrealist group. In this article we try to explain why.

  2. Le général Louis André, l’affaire Dreyfus et l’affaire des « fiches »

    OpenAIRE

    Doessant, Serge

    2009-01-01

    Le général André est commandant de l’École polytechnique lorsqu’en décembre 1894 débute l’affaire Dreyfus par la condamnation du capitaine (X1878). Il est alors, comme presque tout le monde, antidreyfusard, car il ne peut imaginer, lui le militaire dans l’âme, que les sept juges du conseil de guerre se sont unanimement trompés. Louis André avait été nommé un an avant au commandement de l’École alors que le général Auguste Mercier était ministre de la Guerre. Or c’est Mercier (X1852) qui a déc...

  3. Van Calvinisme tot eksistensialisme1: ’n teologiese gesprek met André P. Brink met verwysing na sy memoirs

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    J.H. van Wyk

    2011-06-01

    Full Text Available From Calvinism to existentialism: a theological discussion with André P. Brink with reference to his memoirs In this article the author attempts to develop a theological discussion with the well-known and world-famous writer André P. Brink, on the topics of Calvinism and existentialism. The question at stake is why Brink, who grew up in a South African Calvinist milieu, which was reinforced by his studies at the Potchefstroom University for Christian Higher Education, turned his back on Calvinism and wholeheartedly embraced existentialism during his study in Paris. Why was Potchefstroom exchanged for Paris? Why was Christ replaced by Camus? Did Brink thoroughly compare Calvinism with existentialism or was his decision taken precipitately? This is the fascinating question which the author tries to unravel in this investigation.

  4. Van Calvinisme tot eksistensialisme1: ’n teologiese gesprek met André P. Brink met verwysing na sy memoirs

    Directory of Open Access Journals (Sweden)

    J.H. van Wyk

    2011-06-01

    Full Text Available From Calvinism to existentialism: a theological discussion with André P. Brink with reference to his memoirsIn this article the author attempts to develop a theological discussion with the well-known and world-famous writer André P. Brink, on the topics of Calvinism and existentialism. The question at stake is why Brink, who grew up in a South African Calvinist milieu, which was reinforced by his studies at the Potchefstroom University for Christian Higher Education, turned his back on Calvinism and wholeheartedly embraced existentialism during his study in Paris. Why was Potchefstroom exchanged for Paris? Why was Christ replaced by Camus? Did Brink thoroughly compare Calvinism with existentialism or was his decision taken precipitately? This is the fascinating question which the author tries to unravel in this investigation.

  5. Historical analysis (2000-2005) of the coastal water quality in San Andrés Island, SeaFlower Biosphere Reserve, Caribbean Colombia.

    Science.gov (United States)

    Gavio, Brigitte; Palmer-Cantillo, Shelly; Mancera, J Ernesto

    2010-07-01

    To understand the coastal water quality of San Andrès Island, and provide tools for the management of its marine resources, we present the historical analysis of the island monitoring, which includes ammonia, nitrites, nitrate, phosphates, fecal and total coliforms. The anthropogenic pressure on the coastal system is heavy, with water nutrification, posing at risk seagrass and coral ecosystems. During dry season, biologically available nitrogen is 3-9 times higher than the maximum recommended for coral reefs, while during wet season values are 2-6.4 times the maximum. Biologically available phosphorous is also high, 1-8 times the maximum during dry season, 2-13 times during wet season. In some sites the concentration of pathogenic bacteria is above the limits set by law for primary and secondary contact. It is urgent to improve the management of sewage discharge, the main polluting source of San Andres coastal waters. Copyright 2010 Elsevier Ltd. All rights reserved.

  6. Mida teed siis, kui töötaja on avaldanud soovi firmast lahkuda? / Inge Rumessen, Andres Hall, Mariliin Saar ... [jt.

    Index Scriptorium Estoniae

    2016-01-01

    Küsimusele vastavad PR Strategies partner ja strateegiline konsultant Inge Rumessen, auto24ring juhataja Andrs Hall, vabakutseline loovjuht ja produtsent Mariliin Saar, advokaadibüroo Tark partner Hannes Küün, ettevõtte Ööloom ja Frank kaasasutaja Jan Plaan, haridus- ja teadusministeeriumi personaliosakonna juhataja Margot Saluse, Sorry as Service müügijuht ja asutaja Indrek Põldvee ja EBS-i rahvusvahelise koostöö prorektor Toomas Danneberg

  7. Arhitektuuri sihtkapitali tegevuspreemia 2014 = The Endowment for architecture's prize for activity in the field of architecture 2014 / Epp Lankots, Andres Kurg ; kommenteerinud Ignar Fjuk

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2015-01-01

    Eesti Kultuurkapitali Arhitektuuri sihtkapitali tegevuspreemia 2014: Epp Lankotsa doktoriväitekiri "Moodsa arhitektuuri kriitiline historiograafia. Modernsuse käsitlused Leo Gensi ja Leonhard Lapini arhitektuuriajaloolistes tekstides 1960.-1980. aastail"; Andres Kure doktoriväitekiri ""Boundary disruptions: late-soviet transformations in art, space and subjectivity in Tallinn 1968-1979" ("Segilöödud piirid, hilisnõukogude muutused kunstis, ruumis ja subjektsuses Tallinnas aastatel 1968-1979")

  8. Relative Habitat- and Browse-Use of Native Desert Mule Deer and Exotic Oryx in the Greater San Andres Mountains, New Mexico

    OpenAIRE

    Hoenes, Brock D.; Bender, Louis C.

    2010-01-01

    Introduced oryx (Oryx gazella gazella) have expanded into the San Andres Mountains of south-central New Mexico, but little is known of concurrent habitat used by oryx and desert mule deer (Odocoileus hemionus crooki); the latter in New Mexico is a species of special concern that has declined significantly since the introduction of oryx. We used fecal-pellet and browse surveys in combination with presence modeling to identify differences in relative use of habitat types, distribution, and brow...

  9. Lääne-Virumaal võttis valimistel kõige rohkem hääli Kristiina Ojuland / Andres Pulver

    Index Scriptorium Estoniae

    Pulver, Andres, 1965-

    2007-01-01

    Lääne-Virumaal kogus kõige rohkem hääli Keskerakond, saavutades 7222 valija toetuse. Diagramm: Valimistulemused Lääne-Virumaal. Vt. samas lk. 6-7: Riigikogu valimiste tulemused Lääne-Virumaal ja lk. 15: Kuidas kommenteerite Riigikogu valimiste tulemusi? Vastavad: Marko Pomerants (IRL), Indrek Saar (SDE), Vello Tafenau (ERL), Robert Antropov, Kristiina Ojuland (Reformierakond), Einar Vallbaum, Toomas Varek (Keskerakond), Andres Jaadla (Eestimaa Rohelised)

  10. Vicent Andrés Estellés: la construcció poètica de la identitat valenciana

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    Purificació Mascarell

    2011-10-01

    Full Text Available Cet article aborde la construction de l'identité valencienne dans la poésie de Vicent AndrésEstellés à partir de l'analyse de son style d'écriture (avec un langage proche au populaire et du revise auxthèmes de sa principale oeuvre de contenu nationaliste, le Mural del País Valencià.

  11. The last versification of Jovellanos« El delincuente honrado»: a literary controversy by Andrés Muriel during the decline of Neoclasicism

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    Antonio CALVO MATURANA

    2012-02-01

    Full Text Available This essay analyzes the details of an almost unknown literary controversy: the one that confroted Andrés Muriel and José González de la Cruz (with the secretary of State Mariano Urquijo as arbitrator in 1800. González dared to versity the famous Jovellanos play El delincuente honrado, a nerved that Muriel (a young university professor considered an attack against Neoclassic precepto (prevailing in those days.

  12. Gestión del riesgo para la continuidad del negocio escolar en el I.E.D. Nuevo san Andrés de los Altos.

    OpenAIRE

    Bermeo Leal, Dairo Ernestor

    2014-01-01

    Esta propuesta pretende unir un aspecto netamente empresarial con el ámbito escolar, se analiza bibliografía y experiencias a nivel internacional, nacional y local, que permiten crear un camino asertivo y eficaz en la Gestión del Riesgo para la Continuidad del Negocio Escolar en el I.E.D. Nuevo San Andrés de los Altos, ubicado en la localidad quinta (Usme), de Bogotá D.C., Colombia.

  13. An integrated study of the Grayburg/San Andres Reservoir, Foster and South Cowden fields, Ector County, Texas. Quarterly report, 1 July 1995--30 September 1995

    Energy Technology Data Exchange (ETDEWEB)

    Reeves, J.J.; Trentham, R.C.

    1995-12-31

    The objective of this study is to demonstrate a methodology for reservoir characterization of shallow shelf carbonate reservoirs which is feasible for the independent operator. Furthermore, it will provide one of the first public demonstrations of the enhancement of reservoir characterization using high resolution three dimensional (3-D) seismic data. This particular project will evaluate the Grayburg and San Andres reservoirs in the Foster and South Cowden Fields of Ector County, Texas. The investigators will showcase a multi-disciplinary approach to waterflood design and implementation, along with the addition of reserves by selective infill drilling. This approach in reservoir development will be applicable to a wide range of shallow shelf carbonate reservoirs throughout the United States. Technology transfer will take place through all phases of the project. Production problems associated with shallow shelf carbonate reservoirs are being evaluated by a technical team integrating subsurface geological data, engineering data and 3-D seismic data. The team is using a network of state-of-the-art industry standard software running on high performance computer workstations. Twenty-four Grayburg and seven San Andres thin sections have been evaluated from the J.E. Witcher Well No. 6. This evaluation has been valuable in formulating a depositional model and in definitively dividing the Grayburg and San Andres reservoirs into distinct layers or ``units``.

  14. Configuración de la muerte en las profecías de Andrés en Satanás de Mario Mendoza

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    Jhon Alexánder Monsalve Flórez

    2014-01-01

    Full Text Available Este artículo presenta un análisis semiótico de las profecías de Andrés en la novela Satanás de Mario Mendoza. La muerte es uno de los elementos recurrentes en esta narración y se configura a partir de los vaticinios de Andrés en el momento en que pinta o imagina un retrato. Las figuras, entendidas como elementos mínimos semánticos y consecuentes (semas y sememas, que aparecen en las predicciones, tematizan la muerte, que es valorada eufórica o disfóricamente por los actores de la novela. En este sentido, este artículo presenta el análisis figurativo, narrativo, actancial y temático, y también axiológico de las profecías de Andrés, con base en los métodos propios de la Escuela Semiótica de París.

  15. La otra Nueva España de Andrés Henestrosa: reflexiones de un amigo de los republicanos

    Directory of Open Access Journals (Sweden)

    Manuel López Forjas

    2017-07-01

    Full Text Available En este trabajo se pretende rescatar las memorias y reflexiones sobre la España republicana del escritor oaxaqueño Andrés Henestrosa, quien llegó a sumar 102 años de vida hasta el año de 2008 –cuando falleció. Para ofrecer un panorama que sirva a su vez de introducción a su obra ensayística, se presenta en primer lugar un comentario general sobre el debate que se presentó en México en los años posrevolucionarios sobre las posturas hispanistas en el mundo intelectual y literario; tratando de situar a Henestrosa dentro de ese contexto. En la segunda parte de esta exposición, se verá cómo el escritor oaxaqueño –reivindicando la raíz mestiza como la más influyente en la configuración del México contemporáneo– ofreció una explicación distinta donde intentó rescatar las raíces históricas del pueblo mexicano, poniéndolas en relación con el aporte de los españoles republicanos que conoció. This article attempts to rescue the memories and reflections about the Spanish Republic written by the Oaxacan author Andrés Henestrosa, who lived for 102 years (he died in 2008. To offer a complete view that also helps as an introduction to his essays, in first place there will be a general comment about the ideological discussion that happened in México after the Mexican Revolution around the Hispanic attitudes in the intellectual and the literary world, trying at the same time to situate to Henestrosa in this context. In the second part of this exposition, it will be possible to perceive how the Oaxacan writer -vindicating the “mestizo” root as the most influential in the current México’s political configuration- presented a different explanation where he strove to rescue the historical roots of the Mexican people, relating them with the contributions of the Spanish Republicans that he met in his life.

  16. Qualidade pós-colheita de frutos de tomate cv. Andréa tratados com etileno Postharvest quality of tomato fruits cv. Andréa treated with ethylene

    Directory of Open Access Journals (Sweden)

    Caroline Andreuccetti

    2007-03-01

    Full Text Available O tomate é uma das principais hortaliças cultivadas no Brasil e tratamentos que propiciem o controle do amadurecimento são extremamente desejáveis. Avaliou-se a qualidade pós-colheita de tomates tipo italiano tratados com etileno. Tomates 'Andréa' foram colhidos em campos de produção comercial no estádio verde-maduro, selecionados para presença de danos externos e classificados quanto ao tamanho e cor e posteriormente foram tratados com 100 µL L-1 de etileno. Os ensaios foram planejados com delineamento inteiramente casualizado em esquema fatorial com quatro tratamentos e quinze repetições (n=10. Após a aplicação, os frutos foram divididos em dois lotes. Um lote permaneceu a 20º±1ºC e outro foi mantido a 12,5º±1ºC, ambos sob umidade relativa 90±5%. Tomates do tratamento controle foram mantidos nas mesmas condições de temperatura e umidade relativa. Os frutos foram avaliados após cada mudança de estádio de amadurecimento para as seguintes variáveis: coloração externa (L*a*b*, perda de massa, sólidos solúveis totais, acidez titulável e teor de ácido ascórbico. A aplicação de etileno não influenciou de maneira significativa as variáveis químicas e físicas estudadas. Frutos armazenados à temperatura de 20ºC demonstraram maior porcentagem de perda de massa ao longo do amadurecimento, com média de 2,60%. A relação brix/acidez apresentou pouca variação entre os tratamentos avaliados. Frutos do tratamento controle e mantidos à temperatura de 20ºC apresentaram mudança de coloração mais rápida no início dos experimentos, não sendo observada posteriormente diferença significativa no desenvolvimento da cor dos tratamentos avaliados. O tratamento com etileno não acelerou de forma significativa o amadurecimento de tomates 'Andréa' armazenado sob as duas temperaturas estudadas.Tomatoes are one of the most important vegetable crops grown in Brazil and treatments that facilitate ripening control are

  17. Uso y actitudes relacionados a las drogas en las estudiantes de enfermería de la Universidad Mayor de San Andrés Uso e atitudes relacionados às drogas em estudantes de enfermagem da Universidade Maior de San Andres Use and attitudes about drugs among nursing students at the Universidad Mayor de San Andres

    Directory of Open Access Journals (Sweden)

    Iblin Elizabeth Enriquez Flores

    2004-04-01

    Full Text Available Este trabajo representa los resultados del Uso y Actitudes relacionando el alcohol, tabaco, Hojas de coca, tranquilizantes y anfetaminas en Estudiantes de Enfermería de la Universidad Mayor de San Andrés. El objetivo es analizar las actitudes mediante el uso de diferentes substancias con aquellos que no usan en los últimos 12 meses. Los datos fueron recolectados en Agosto del 2002, utilizando un cuestionario auto administrado y distribuido, garantizando el anonimato. Se obtuvieron estos resultados: Las actitudes relacionadas a las drogas aprueban el uso de hojas de coca, uso de alcohol, uso de tranquilizantes y desaprueban el uso de cocaína. El uso personal de drogas en los últimos 12 meses corresponde a: hojas de coca diariamente, alcohol menos que una vez por semana y tabaco diariamente. El principal motivo de uso de estas drogas vinculase a la práctica religiosa; los estudiantes son introducidos por primera vez por familiares y por amigos/enamorados.Este trabalho representa os resultados do Uso e Atitudes relacionados ao álcool, tabaco, folhas de coca, tranqüilizantes e anfetaminas em estudantes de enfermagem da Universidade Mayor de San Andrés. O objetivo é analisar as atitudes mediante o uso das diferentes substâncias com aqueles que usaram ou não drogas nos últimos 12 meses. Os dados da amostra estratificada e intencional foram coletados em agosto de 2002, utilizando um questionário auto administrado distribuído para preservar o anonimato. Obtiveram-se estes resultados: as atitudes relacionadas às drogas demonstram a aprovação do uso das folhas de coca, álcool, tranqüilizantes e desaprovam o uso da cocaína. O uso pessoal de drogas nos últimos 12 meses corresponde a: às folhas de coca diariamente, ao álcool menos que uma vez por semana, e tabaco diariamente. O principal motivo do uso destas drogas vincula-se a prática religiosa; os estudantes são introduzidos pela primeira vez pelos familiares, pelos amigos

  18. El arte de la conversión: modelos educativos del Colegio de San Andrés de Quito

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    Andrea Lepage

    2007-06-01

    Full Text Available El ensayo analiza el papel que desempeñó el Colegio de San Andrés de Quito en la conversión de los indígenas durante el siglo XVI y el florecimiento de un centro importante de producción artística. El artículo propone que la designación actual del colegio, como una escuela de arte, puede ser una consecuencia tardía de la inestable relación entre arte y religión, tal como fue cultivada dentro de la institución franciscana. Se trató, por lo tanto, de una superposición del valor religioso sobre el artístico, mediante el cual se adoctrinaba a los estudiantes. El artículo enfatiza en la apropiación de destrezas artísticas por parte de los indígenas, quienes adquirieron dominio sobre estas artes, las mercadearon y provocaron una inesperada tensión en las concepciones franciscanas acerca de la religión y el uso del arte.

  19. Harm Reduction Unit of the City of Santo André, São Paulo State, Brazil: An Evaluation

    Directory of Open Access Journals (Sweden)

    Silvia Moreira da Silva

    2010-12-01

    Full Text Available The Harm Reduction Unit (HRU in Santo André (São Paulo State was created to improve the health of people who either live or work on the streets: drug users, commercial sex workers (male and female, men who have sex with men, sexually exploited adolescents, transsexuals, transvestites, lesbians, and women working in brothels. This project was undertaken to evaluate the HRU from the perspective of its users. A semi-structured interview was administered to nineteen users from different segments of the populations served by the unit. The major weaknesses of the HRU were felt to be its inconsistent presence in some areas and the absence of psychologists to provide follow-up care. The unit was seen as promoting better health, increased use of condoms, reduction in drug usage, increased access and use of health care services, and less sharing of equipment used in drug consumption. Users see the HRU as a sympathetic presence whose ongoing work provides them with a sense of security and protection. The impact of the HRU went beyond harm reduction; users reported transformative changes such as increased awareness of their social rights and knowledge about how those rights can be demanded. Users had been given new tools to face their problems and seek access to education, work, and housing. Key words: harm reduction, illegal drugs, health service evaluation, social problems

  20. Chamaerops humilis L. var. argentea André date palm seed oil: a potential dietetic plant product.

    Science.gov (United States)

    Nehdi, Imededdine Arbi; Mokbli, Sadok; Sbihi, Hassen; Tan, Chin Ping; Al-Resayes, Saud Ibrahim

    2014-04-01

    Chamaerops humilis L. var. argentea André (C. humilis) date palm seeds are an underutilized source of vegetable oil, and no studies describing their physicochemical characteristics to indicate the potential uses of this seed or seed oil have been reported. The oil content of the seeds is about 10%, mainly composed of oleic acid (38.71%), lauric acid (21.27%), linoleic acid (15.15%), palmitic acid (9.96%), and stearic acid (7.17%). The tocol (tocopherols and tocotrienols) content is 74 mg/100 g, with δ-tocotrienol as the major contributor (31.91%), followed by α-tocotrienol (29.37%), γ-tocopherol (20.16%), and γ-tocotrienol (11.86%). Furthermore, this oil shows high thermal stability. The differential scanning calorimetery curves revealed that the melting and crystallization points are 9.33 °C and -15.23 °C, respectively. © 2014 Institute of Food Technologists®

  1. Il limite e l’altrove: il mito di Jean-Paul Belmondo nella Siberia di Andreï Makine

    Directory of Open Access Journals (Sweden)

    Elisabetta Abignente

    2011-04-01

    Full Text Available The narrative work of Andreï Makine (1957, a French writer of Siberian origin, is situated on the border between two geographical and cultural spaces: on the one hand the wide, wild and snowy Siberia of his childhood; on the other hand France, a mythic place which the main characters, often teenagers, of his novels look at as a model. The contrast between these two worlds is described in a particularly forceful way in one of his early novels, Au temps du fleuve Amour (1994, in which the author tells the overwhelming effect of the screening of a popular French comedy with Jean-Paul Belmondo (Le Magnifique, 1973 in a small Siberian village. Looking closely at the entire sequence which is devoted to the film in the novel, the paper aims to reconstruct the process of mythicizing the Belmondo character by the three young protagonists and to investigate the functions that the episode covers in the novel. Focusing on the different narrative levels that characterize the film plot, we show how the “phenomenon Belmondo” embodies in the novel the idea of a triple border: a geographic one (Europe/Asia, an expressive one (writing/imagine and, above all, an imaginary one (reality/fiction. We also show how this phenomenon refers, in the novel, to one of the central themes of Makine’s work: literary vocation.

  2. A "coca-cola" shape: cultural change, body image, and eating disorders in San Andrés, Belize.

    Science.gov (United States)

    Anderson-Fye, Eileen P

    2004-12-01

    Eating disorders have been associated with developing nations undergoing rapid social transition, including participation in a global market economy and heavy media exposure. San Andrés, Belize, a community with many risk factors associated with the cross-cultural development of eating disorders, has shown remarkable resistance to previously documented patterns, despite a local focus on female beauty. Drawing on longitudinal person-centered ethnography with adolescent girls, this article examines why this community appears exceptional in light of the literature. First, community beauty and body image ideals and practices are explicated. Then, a protective ethnopsychology is proposed as a key mediating factor of the rapid socio-cultural change among young women. Finally, possible nascent cases of eating disordered behavior are discussed in light of their unique phenomenology: that is, having to do more with economic opportunity in the tourism industry and less with personal distress or desire for thinness. Close, meaning-centered examination of eating and body image practices may aid understanding and prevention of eating disorders among adolescents undergoing rapid social change in situations of globalization and immigration.

  3. Experiência e Utopia em Theodor W. Adorno, André Gorz e François Dubet

    Directory of Open Access Journals (Sweden)

    Sílvio César Camargo

    2007-01-01

    sociedade contemporânea. Conceito bastante complexo quanto a sua possibilidade de apreensão pela sociologia, experiência se refere tanto a problemas relativos ao conhecimento e suas possibilidades, mas também para as possibilidades de transformação da sociedade. Entende-se que há três teóricos da sociedade contemporânea, que partindo de bases epistemológicas diferentes, problematizam a emancipação humana a partir de uma singular atenção ao conceito de experiência. Theodor W. Adorno, André Gorz e François Dubet representam três formas de pensamento sobre a sociedade bastante diferentes, mas que possuem em comum o interesse normativo, e seu confronto nos mostra a importância do conceito de experiência para a compreensão da sociedade contemporânea e para pensar-se a utopia.

  4. Andrés piquer and the neo-hippocratic teaching of medicine in eighteenth century Spain.

    Science.gov (United States)

    Angel y Espinós, Jesús

    2010-01-01

    Eighteenth century Spain witnessed a revaluation of the Hippocratic works as a result of the growing criticism of the Galenism dominant in the Spanish University of the time. Probably the most important author in this reformist trend was Andrès Piquer y Arrufat (1711-1772), eclectic philosopher, university professor and doctor to the Kings Fernando VI and Carlos III. His desire to transform medical university instruction following Hippocrates' rules led him to make some of the first Hippocratic treatises from ancient Greek to Spanish, for the first time. Among these treatises, the translation and commentary of Epidemics 1 and 3, and partially of Epidemics 2, are especially noteworthy. This medical and philological work relates not only to Hippocrates but also to the medical concepts of Thomas Sydenham, the English Hippocrates. The Clinical Histories and descriptions of katastasies in his Observationes medicae (London, 1676) exerted a great influence not only on A. Piquer but also on many Spanish doctors. Moreover, the works of Herman Boerhaave and especially of his pupil Gerhard van Swieten left their imprint on the ideas of the Spanish doctor. Besides his translations, A. Piquer wrote many treatises based on Hippocratic teaching for university students, in Latin as well as in Spanish. His Praxis Medica was translated into Portuguese and his Tratado de las calenturas (About the fevers) into French.

  5. Individual determinants of fish choosing in open-air street markets from Santo André, SP/Brazil.

    Science.gov (United States)

    Vasconcellos, Juliana Parreira; Vasconcellos, Silvio Arruda; Pinheiro, Sonia Regina; de Oliveira, Thaís Helena Nishikata; Ribeiro, Naassom Almeida Souza; Martins, Cassia Neves; Porfírio, Bruno Augusti; Sanches, Sandra Abelardo; de Souza, Orlando Bispo; Telles, Evelise Oliveira; Balian, Simone de Carvalho

    2013-09-01

    The objective of this study was to identify the determinants of fish consumption in the population that attends open-air street markets in the city of Santo André, SP, Brazil.We performed a survey, covering approximately 482 people in 49 street markets.It consisted of free-answer questions, half open choice and half multiple-choice options, for the identification and evaluation of socioeconomic factors that facilitate and hinder fish consumption.A descriptive analysis of the data and further tests were used to determine the association between variables and linearity with consumption, with a significance level of 5%. The most commonly cited types of fish consumed were hake, sardine and dogfish. The factors that facilitate the purchase and consumption of fish are listed as follows: a preference for purchasing fish at street markets, appearance, firmness, fresh presentation, frozen presentation, as well as the respondent's education and individual monthly income. Limiting factors were identified as the price and the presence of spines. Perishability, odour, ethnicity, proximity to points of sale of residence and work, gender, age, number of people in the household, presence of children and acquisition supermarket were not characteristics that influenced decisions about fish consumption. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. ¿Influyó Suárez en el pensamiento de Andrés Bello?.

    Directory of Open Access Journals (Sweden)

    Milagros Otero Parga

    2017-09-01

    Full Text Available Suárez es uno de los más insignes juristas españoles. La profundidad y originalidad de su pensamiento ha inspirado a muchos autores posteriores hasta la actualidad de manera que puede decirse que existe una escuela suareciana conocida y activa. Este hecho que engrandece nuestra tradición jurídica, debe ser conservado y acrecentado. El artículo que ahora se presenta quiere llegar un poco más allá. Quiere buscar la influencia indirecta de Suárez en aquellos autores que sin mencionarlo expresamente siguen los cauces de su pensamiento aplicándolos a ámbitos de conocimiento no estrictamente jurídicos. Este es el caso de Andrés Bello, un personaje americano de gran importancia. Político, diplomático y jurista de formación humanista clásica, organizó la vida de los seres humanos en sociedad buscando la justicia y la paz. Creo que la influencia de Suárez en personajes de este tipo debe ser considerada, conocida y valorada porque expanden su magisterio de forma insospechada.

  7. War songs and songs of war: the poetry in B minor by Fabrizio De André

    Directory of Open Access Journals (Sweden)

    Gleiton Lentz

    2010-11-01

    Full Text Available The 2nd half of last century, the Italian composer Fabrizio De André (1940-1999 occupied a prominent place in the history of Italian song and even the modern Italian poetry. His fans admire the moral courage and artistic coherence with which he, in the post-war Italian society, through his libertarian and pacifist songs, portrayed the world of the marginalized, the rebels and the prostitutes, and other characters on the margins of society, among those, the war combatant, hero of lost victories on the battlefield. Three of his songs are emblematic: La Ballata dell'eroe, La Guerra di Piero and Girotondo. Three poems that talk about war, death, and the figure of the combatant as an outcast of society, that kills him and then relegates him to oblivion, on behalf of the Fatherland. Exposing his provocative vision of post-war society by showing two videos of the composer is the purpose of this presentation.

  8. The social construction of bath in two communities temazcal of the mixteca region: Santiago Yolomecatl and San Andres Chicahuaxtla

    Directory of Open Access Journals (Sweden)

    Alberto Valdés Cobos

    2013-01-01

    Full Text Available The bathroom of temazcal is a knowledge of pre-Hispanic roots still practiced in rural and indigenous communities in our country. Studies on the temazcal have focused on its forms of construction and operation, however, the many therapeutic benefits temazcal bath attached to the human body, and women in particular, not have been sufficiently documented. In this case, two communities of the Oaxacan mixteca were studied: Santiago Yolomecatl and San Andrés Chicahuaxtla. In this study, a questionnaire was applied to 20 per cent of families in each of the communities, a questionnaire to allopathic doctors and six stories of life at temazcaleras. The results indicate a coincidence between patients and doctors in the study populations on the medicinal uses of the temazcal bath: after childbirth and for muscle aches, however, interviewed temazcaleras indicate diseases that cures this bath are: angina, flu, rheumatism,scars, muscle aches after childbirth and cramping. For its part, doctors support the idea of preserving the temazcal bath because it is a healing means to treat diseases through steam and faster recovery of the body. The constructivist analysis of the responses gathered in questionnaires and life stories shows that the medicinal uses of the temazcal, before being recognised as such go through a process of evaluation, filtration and social construction. This process of acceptance, perception and recognition occurs through rules of knowledge, ideological connotations, rules and socialsymbols.

  9. THE SOCIAL CONSTRUCTION OF BATH IN TWO COMMUNITIES TEMAZCAL OF THE MIXTECA REGION: SANTIAGO YOLOMECATL AND SAN ANDRES CHICAHUAXTLA

    Directory of Open Access Journals (Sweden)

    Alberto Valdés-Cobos

    2013-04-01

    Full Text Available The bathroom of temazcal is a knowledge of pre-Hispanic roots still practiced in rural and indigenous communities in our country. Studies on the temazcal have focused on its forms of construction and operation, however, the many therapeutic benefits temazcal bath attached to the human body, and women in particular, not have been sufficiently documented. In this case, two communities of the Oaxacan mixteca were studied: Santiago Yolomecatl and San Andrés Chicahuaxtla. In this study, a questionnaire was applied to 20 per cent of families in each of the communities, a questionnaire to allopathic doctors and six stories of life at temazcaleras. The results indicate a coincidence between patients and doctors in the study populations on the medicinal uses of the temazcal bath: after childbirth and for muscle aches, however, interviewed temazcaleras indicate diseases that cures this bath are: angina, flu, rheumatism, scars, muscle aches after childbirth and cramping. For its part, doctors support the idea of preserving the temazcal bath because it is a healing means to treat diseases through steam and faster recovery of the body. The constructivist analysis of the responses gathered in questionnaires and life stories shows that the medicinal uses of the temazcal, before being recognised as such go through a process of evaluation, filtration and social construction. This process of acceptance, perception and recognition occurs through rules of knowledge, ideological connotations, rules and social symbols.

  10. Phase diagram of a non-Abelian Aubry-André-Harper model with p -wave superfluidity

    Science.gov (United States)

    Wang, Jun; Liu, Xia-Ji; Xianlong, Gao; Hu, Hui

    2016-03-01

    We study theoretically a one-dimensional quasiperiodic Fermi system with topological p -wave superfluidity, which can be deduced from a topologically nontrivial tight-binding model on the square lattice in a uniform magnetic field and subject to a non-Abelian gauge field. The system may be regarded as a non-Abelian generalization of the well-known Aubry-André-Harper model. We investigate its phase diagram as a function of the strength of the quasidisorder and the amplitude of the p -wave order parameter through a number of numerical investigations, including a multifractal analysis. There are four distinct phases separated by three critical lines, i.e., two phases with all extended wave functions [(I) and (IV)], a topologically trivial phase (II) with all localized wave functions, and a critical phase (III) with all multifractal wave functions. Phase (I) is related to phase (IV) by duality. It also seems to be related to phase (II) by duality. Our proposed phase diagram may be observable in current cold-atom experiments, in view of simulating non-Abelian gauge fields and topological insulators/superfluids with ultracold atoms.

  11. Anderson localization in the non-Hermitian Aubry-André-Harper model with physical gain and loss

    Science.gov (United States)

    Zeng, Qi-Bo; Chen, Shu; Lü, Rong

    2017-06-01

    We investigate the Anderson localization in non-Hermitian Aubry-André-Harper (AAH) models with imaginary potentials added to lattice sites to represent the physical gain and loss during the interacting processes between the system and environment. By checking the mean inverse participation ratio (MIPR) of the system, we find that different configurations of physical gain and loss have very different impacts on the localization phase transition in the system. In the case with balanced physical gain and loss added in an alternate way to the lattice sites, the critical region (in the case with p -wave superconducting pairing) and the critical value (both in the situations with and without p -wave pairing) for the Anderson localization phase transition will be significantly reduced, which implies an enhancement of the localization process. However, if the system is divided into two parts with one of them coupled to physical gain and the other coupled to the corresponding physical loss, the transition process will be impacted only in a very mild way. Besides, we also discuss the situations with imbalanced physical gain and loss and find that the existence of random imaginary potentials in the system will also affect the localization process while constant imaginary potentials will not.

  12. Apartheid Spies: The Character, the Reader, and the Censor in André Brink’s A Dry White Season

    Directory of Open Access Journals (Sweden)

    Giuliana Iannaccaro

    2014-05-01

    Full Text Available André Brink’s novel A Dry White Season (1979 is strictly connected with the time and place in which it was written. Its dialogue with the real Johannesburg of the late Seventies is manifest: characters and plot are grafted on real events, like the youth riots in Soweto (1976 and the death of Steve Biko in the hands of the Security Police (1977. Brink’s early novels have been commended for their political commitment, but also criticized for being ‘easily’ documentary. Yet, A Dry White Season’s structure is rather complex, and its fabricated nature is shown to the reader through the device of the double internal narrator and the considerable number of ‘documents’ discovered and employed – each telling its own truth. The metaphor of the ‘spying gaze’ proposed here is useful in order to point out the interconnections between story and history, as it shows the way in which a complex and multi-layered narrative structure succeeds in both reflecting and exposing the intricate apartheid system devised to control and ‘discipline’ its own citizens. In the novel, most of the characters intrude into the life of the others and are intruded upon, included peaceful citizens who are obliged to defend themselves from an oppressive and violent police State. At the same time, also the reader is drawn into the dangerous spying game, above all when he/she is introduced into that notorious site of interrogation, torture and detention which was the Johannesburg Police Station in John Vorster Square. The last part of the essay takes into consideration the South African censorship system in force at the time, to show that the activity of surveillance is both intrinsic to the narration and external, related to the conditions of the novel’s composition and appearance on the literary market.

  13. Inductores de lágrimas: andrógenos y gammaglobulinas humanas Tears inducers: androgens and human gammaglobulinas

    Directory of Open Access Journals (Sweden)

    María Nila Santos Lagresa

    2000-06-01

    Full Text Available Se comparan las respuestas terapéuticas en pacientes con diagnóstico de Síndrome de Sjögren que padecen de queratoconjuntivitis seca resistentes a los tratamientos tradicionales de lágrimas artificiales, lentes y otros, en dos grupos de pacientes de 18 y 32 casos con tratamientos de gammaglobulina humana: intacglobín (100 mg por kilo de peso cada 15 días por vía subcutánea interescapular por 3 meses y andrógenos de depósito (100 mg cada 15 días por vía im durante 3 meses. Se evaluaron los niveles de inmunoglobulinas IgG, IgA, IgM e IgE, recuento de células sanguíneas factor reumatoideo, proteína C reactiva y estudio microbiológico. Ambas terapéuticas muestran una mejoría estadísticamente significativa p Therapeutical responses are compared in patients diagnosed of Sjögren syndrome, presenting with keratoconjunctivitis sicca resistant to traditional treatments of artificial tears, lenses and others in two groups of patients (18 and 32 cases treated with human gammaglobulin: intacglobin (100 mg/body weight every 15 days in a intercapsular subcutaneos way for 3 months, and depot androgens (100 mg every 15 days in an intramuscular way for three months. Level of IgG, IgA, IgM, and IgE immunoglobulins, count of blood cells-rheumatoid factor, C-reactive protein, and microbiological study. Both treatments show an significant statistically improve p < 0,001 in results obtained in Shirmer I test, and in negative corneal injuries, assessed using slit lamp after fluorescein staining. We propose advantageous use of gammaglobulins because of contraindications on utilization of androgens.

  14. High-resolution stratigraphic forward modeling: A case study of the lower-middle San Andres formation, Permian basin

    Energy Technology Data Exchange (ETDEWEB)

    Shuster, M.W. (KSEPL (Shell Research), Rijswijk (Netherlands)); Childers, D.W. (Shell Western Exploration and Production Inc., Houston, TX (United States))

    1993-09-01

    This study has attempted to calibrate Shell's two-dimensional (2-D) basin modeling program as an exploration tool by simulating the stratigraphy of a mixed carbonate/clastic third-order depositional sequence. The lower-middle San Andres Formation was selected because available log, core, and outcrop data from the Northwest Shelf area, Permian basin, provided an excellent calibration set. A regional stratigraphic cross section from the Cato-Chaveroo to the Wasson fields was constructed delineating lithology and porosity distribution. Approximately 10 shoaling-upward depositional cycles were interpreted. A higher frequency, five-in-one cyclicity was also interpreted based on core and outcrop data. The observed stratigraphy was simulated using a composite eustasy consisting of third-order (2,000,000 yr), fourth-order (100,000 yr), and fifth-order (20,000 yr) sinusoids each at five-meter amplitudes. Subsidence input was constrained by back-stripped tectonic subsidence curves calculated from well data. Sedimentation parameters were interactively derived. New empirically based algorithms were used to model Dunham lithofacies, environmental facies, and sabkha anhydrite distribution. Synthetic log and 2-D synthetic seismic profiles were constructed from the simulation output. The simulation results suggest that (1) relative sea level is the dominant control on the observed depositional cyclicity, (2) the distribution of regional seal facies (anhydrite) reflects falling sea level and prolonged exposure, (3) limestone-dolomite trends on the shelf are grossly related to environment and (4) the distribution of grainstones and packstones (potential reservoirs) occurs as fourth- and fifth-order offlapping and aggradational pods. The synthetic log signatures compared to [open quotes]real[close quotes] logs substantiate the interpreted depositional cyclicity, but also point out the difficulty in interpreting high-order cycles based on log data alone.

  15. La gestión de los recursos comunales y la igualdad en la comunidad de San Andrés de Soria

    OpenAIRE

    Martínez Rodríguez, Laura

    2014-01-01

    San Andrés tiene algo distintivo y excepcional con respecto a los pueblos circundantes, y es la posesión de una Dehesa y de un Arca-archivo con documentación referente a la gestión de los bienes comunales desde el siglo XIV. Estos dos elementos posibilitan obtener una visión antropológica desde el elemento histórico y el medio natural que en muy contadas ocasiones aparecen con tanta claridad. El objetivo de esta investigación es conocer en profundidad el significado y construcción del valor d...

  16. Regulación por andrógenos y estrógenos de la gliosis tras lesiones cerebrales en rata

    OpenAIRE

    Sampaio Barreto, George Emilio

    2011-01-01

    Los andrógenos y los estrógenos modulan la supervivencia neuronal, la diferenciación glial y la expresión génica en muchas áreas del sistema nervioso durante el desarrollo. Además, estas hormonas tienen efectos protectores frente al daño neuronal causado por diversas patologías neurodegenerativas, traumáticas y toxicas durante la vida adulta. Nuestra hipótesis es que al menos una parte de las acciones neuroprotectoras de la testosterona y el estradiol puede estar mediada por acciones so...

  17. El modelo de aprendizaje alostérico de Andre Giordan y su aplicación a la capacitación de adultos.

    OpenAIRE

    Aguilar Angeletti, Ana Jesus; Facultad de Psicología Leopoldo Chiappo Galli de la Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    Aspectos relevantes de la investigación realizada por la autora, titulada “Una aproximación del Modelo Alostérico de aprendizaje a la capacitación de adultos: análisis cualitativo de las concepciones distorsionadas sobre educación sexual de profesores de educación secundaria”, son presentados, analizados y evaluados, concluyendo que el Modelo Alostérico de Aprendizaje propuesto por André Giordan para el proceso enseñanza-aprendizaje de los niños, puede ser exitosamente aplicado en adultos. An...

  18. PEDREÑO CÁNOVAS, Andrés (COORD. (2014, De cadenas, migrantes y jornaleros. Los territorios rurales en las cadenas globales agroalimentarias. Talasa, Madrid

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Muñoz Sánchez

    2015-01-01

    Full Text Available La monografía aquí reseñada está elaborada por 18 reconocidos autores procedentes de España, México, Brasil, Uruguay y Argentina. Todos ellos coordinados por la figura de Andrés Pedreño y auspiciado por un paraguas intelectual común radicado en el proyecto de investigación Sostenibilidad social de los nuevos enclaves productivos agrícolas: España y México

  19. La lengua francesa en la administración vaticana del siglo XVI. Cartas de Andrés de Castillo a la familia Granvela

    OpenAIRE

    García Requena, Raquel

    2013-01-01

    A partir del Epistolario inédito de Antonio Perrenot de Granvela, custodiado en la Biblioteca Nacional de España, se han editado un centenar de cartas, escritas en francés, por el protonotario Andrés de Castillo. Las cartas comprenden el período entre 1537 y 1544 y abordan los asuntos relativos a las cuestiones administrativas y jurídicas de la familia Granvela ante la Santa Sede. Las cartas pertenecen a los códices: 7906 y 20210 de la Biblioteca Nacional de España con sede en Mad...

  20. Velocidad de descomposición de la hojarasca en diferentes sustratos de manglar en San Andrés Isla, Caribe colombiano

    OpenAIRE

    Mancera P. José Ernesto; Medina Calderón Jairo; Sierra Rozo Omar Alfonso; Santos-Martínez Adriana

    2007-01-01

    La degradación de la hojarasca de manglar fue estudiada en diferentes sustratos de tres humedales de manglar
    en San Andrés isla, Caribe colombiano. Las tasas de descomposición de Rhizophora mangle (mangle rojo),
    Laguncularia racemosa (mangle blanco) y Avicennia germinans (mangle negro) fueron medidas en bolsas tipo
    malla. Algunas bolsas fueron dispuestas bajo el suelo, otras sumergidas en el agua, y otras sobre la superficie
    del suelo. Dos humedales...

  1. Barbosa Filho, André y Castro, Cosette : Comunicación Digital: Educación tecnología y nuevos comportamientos.

    Directory of Open Access Journals (Sweden)

    Yorney Suárez

    2008-12-01

    Full Text Available En el texto de André Barbosa y Cosette Castro “Comunicación Digital”. Educación, Tecnología y Nuevos Comportamientos, los autores destacan la importancia de crear un espacio a través de un libro que promueva la reflexión del vasto y siempre cambiante conocimiento de la comunicación, el cual produce efectos directos y cada día, más significativos, sobre la cultura y el comportamiento del hombre.

  2. El Dioscórides de Andrés Laguna en los textos de Cervantes: de la materia medicinal al universo literario

    OpenAIRE

    Francisco López-Muñoz; Cecilio Álamo

    2007-01-01

    The literary works of Miguel de Cervantes have been widely studied from numerous points of view, including the medical one. In the present work, we defend the hypothesis that the Andrés Laguna version of Dioscorides was the source used by Cervantes in his literary passages related to therapeutic aspects, especially in relation to plants with medicinal properties. This book, a copy of which was in Cervantes’ private library, is the only medical treatise cited by the novelist in any of his writ...

  3. The transmedia art installation in the decades of 1960/1970 and in the contemporaneity (André Parente and Kátia Maciel

    Directory of Open Access Journals (Sweden)

    Natasha Marzliak

    2016-06-01

    Full Text Available The art in the context of transmedia, affected by resources from various media such as film, video and new audiovisual technologies, goes beyond borders, open passages and moving spaces and temporalities suggesting public participation. From a comparative and temporal proposition, this study aims to draw dialogic possibilities of the concepts and practices of the vanguard transmedia art installation that began in the 1960s and lasted throughout the 1970s – especially those of the Fluxus group, Jack Smith, expanded Cinema, environmental manifestations of some Brazilian artists (like Helio Oiticica and today, focusing on two Brazilian artists: André Parente and Kátia Maciel.

  4. El problema moral de la obra de arte en El inmoralista de André Gide y su posible explicación hermenéutico-existencial

    OpenAIRE

    Germán Darío Vélez.

    2012-01-01

    Imponiéndose una estricta moral del cuidado de sí, un hombre consigue escapar a una enfermedad mortal. Los principios de la cura personal son convertidos por él en doctrina. El rigor de esa doctrina acaba con la vida de su esposa. Abandonado a sí mismo y a sus remordimientos, pide socorro a sus amigos...� Este es el argumento de El inmoralista, de André Gide, y del problema mayor de la ética que plantea: ¿cómo apropiarse de sí sin perder al otro? Mediante una lectura hermenéutico-existencial ...

  5. Noticia de unas cartas dirigidas al P. Juan Andrés Morell que se conservan en la biblioteca-archivo de la "Casa d'Ordunya" del Castell de Guadalest

    OpenAIRE

    Martínez Solbes, Juan Pedro

    1996-01-01

    En el proceso de catalogación de la biblioteca-archivo de la Casa d'Ordunya, en Castell de Guadalest, se han localizado quince cartas dirigidas al jesuita Juan Andrés Morell, emparentado con la familia Orduña, y una del propio Andrés dirigida a Gregorio Mayans, a su vez autor, junto al P. Bartolomé Pou y otros, de las misivas que constituyen este epistolario desconocido. During the process of the cataloguing of the Library-Archives of the Casa d'Ordunya of Guadalest, the discovery...

  6. Nivel de consumo diario de frutas y verduras en escolares con sobrepeso y obesidad del primer y segundo grado de primaria de la Institución Educativa Particular San Andrés. Lima. Mayo 2011

    OpenAIRE

    Alfaro, katherine; Institución Educativa Particular San Andrés

    2013-01-01

    Objetivos: Determinar el nivel de consumo diario de frutas y verduras en escolares con sobrepeso y obesidad de primer y segundo grado de nivel primario de la IEP San Andrés. Diseño: Estudio descriptivo, transversal, observacional y prospectivo. Institución: Institución Educativa Particular San Andrés. Participantes: Veintisiete escolares con sobrepeso y 33 con obesidad, de primer y segundo grado de nivel primaria. Intervenciones: Aplicación de formato de frecuencia de consumo de frutas y verd...

  7. Adolescentes em situação de rua: prostituição, drogas e HIV/AIDS em Santo André, Brasil Street youth: prostitution, drugs and HIV/AIDS in Santo André-Brazil

    Directory of Open Access Journals (Sweden)

    Eliane Lima Guerra Nunes

    2009-04-01

    Full Text Available O objetivo do estudo foi investigar as condições de vida de adolescentes do sexo feminino em situação de rua, envolvidas com o abuso de drogas e com a prostituição, visando orientar estratégias de prevenção às Doenças Sexualmente Transmissíveis - DST/AIDS. Foram entrevistadas sete adolescentes entre 14 e 19 anos, por meio de roteiro semi-estruturado com questões sobre escolaridade; desligamento da família; violência; histórico de uso de drogas, sexualidade e existência de DST/AIDS; vida na rua e futuro. Observou-se que os principais motivos que levaram essas adolescentes à rua foram violência doméstica; baixo nível sócio-econômico familiar e abuso de múltiplas drogas. As entrevistadas afirmaram conhecer medidas preventivas para as DST/AIDS, porém não as aplicaram aos clientes fixos e namorados. A análise dos resultados obtidos nesta pesquisa confirma a importância da criação de estratégias específicas para as DST/AIDS, além da adequação da rede educacional e de atenção psicossocial às necessidades das adolescentes para a garantia de seus direitos e conquista da emancipação.The aim of this study was to investigate living conditions of female street adolescents, who are involved with illicit and licit drugs, and with prostitution, in the city of Santo André, as well as to tailor strategies for STD/AIDS prevention. We have interviewed seven adolescents, aged from 14 to 19 years old, using a semi-structured questionnaire with questions about education, family disaffection, violence, living on the streets, history of drug use, sexuality, level of information about STD/AIDS, and hopes for the future. We observed that among the reasons for these adolescents to live on the streets were domestic violence, low socioeconomic level, and drug abuse. They stated that they are aware of STD/AIDS preventive measures, but they do not bring them into effect with steady partners and boyfriends. The analysis of our results

  8. Bathyodontus mirus (Andrássy, 1956, first record of a representative of the suborder Bathyodontina (Nematoda, Mononchida in the Iberian fauna

    Directory of Open Access Journals (Sweden)

    Peña-Santiago, R.

    2010-12-01

    Full Text Available Bathyodontus mirus (Andrássy, 1956 Hopper & Cairns, 1956, collected in sand dunes of SW Iberian peninsula, is studied. Description, measurements and illustrations (LM pictures are provided. Iberian specimens are briefly compared to other known populations of the species. And a compendium of Bathyodontus species, including a key to their identification, is also given. This is the first record of a representative of the nematode suborder Bathyodontina in the Iberian-Balearic range and in the Mediterranean region.Se estudia la especie Bathyodontus mirus (Andrássy, 1956 Hopper y Cairns, 1956, recolectada en dunas de arena en el suroeste peninsular. Se presentan una descripción, medidas e ilustraciones (fotografías con microscopía óptica. Los ejemplares ibéricos se comparan brevemente con otras poblaciones conocidas de la misma especie. Y se ofrece un compendio de las especies del género Bathyodontus, incluida una clave para su identification. Se trata de la primera cita de un miembro del suborden Bathyodontina en el ámbito Ibero-balear y en la región Mediterránea.

  9. “Better a disaster of fidelity to the Event”: Event and Failure in André Breton’s Nadja

    Directory of Open Access Journals (Sweden)

    Camelia Raghinaru

    2015-06-01

    Full Text Available This essay starts from the premise that André Breton’s First Manifesto of Surrealism constitutes the ‘event’ of that movement (i.e., ‘event’ as defined in Alain Badiou’s Ethics, an event subsequently betrayed by its subject, André Breton, in his encounter with Nadja. Situated between rupture and repetition, the opportunity of the event returns in the Second Manifesto of Surrealism. Taking as its target Breton’s novel Nadja, the essay addresses the issue of event as repetition and explores the ramifications of the ‘failure’ to ‘imagine’ one’s continued fidelity to the event. Consequently, this article reads Nadja as a ‘failure’: the failure posed by representation itself, but also the failure of representation to completely annihilate the promise of a “beyond” encrypted in the project of surrealist imagination. Thus, I would like to play off the idea of failure in two complementary ways. First, I look at the ‘failure’ that is more significant than any achievement. Second, I address the failures at particular missed moments in history, expressed as a series of ‘returns’ in Nadja. Finally, the point of tension between the two types of failures in Nadja elicits a reading of Breton as a reactive, rather than an immortal Subject.

  10. Une traductrice d'andré gide devant le problème de la fidélité de la traduction

    Directory of Open Access Journals (Sweden)

    Breda Cigoj Leben

    1984-12-01

    Full Text Available Le succès littéraire d'André Gide ne fut ni prompt ni facile. L'écrivain, né en 1869, débuta dans les. lettre                               en 1891 avec les Cahiers d'André Walter, mais il ne s'affirma qu'en 1909, c' st-à­ dire à quarante ans passés, avec la Porte étroite. La situation de l'auteur incompris, il la subit d'abord avec amertume, il l'ac­ cepta ensuiter avec orgueil. Il commença même                        à exagérer ses "fours". Après 1909, l'intérêt pour l'oeuvre de Gide va croissant, le tira­ ge de ses éditions augmente, on fait des réimpressions et l'on de­ mande de plus en· plus souvent l'autorisation de traduire ses oeuv­ res récentes ou antérieures.

  11. Minimalism and sociability in crisis: masks of alterity in the works of Marcelino Freire and André Sant’Anna

    Directory of Open Access Journals (Sweden)

    Ângela Maria Dias

    2017-06-01

    Full Text Available Brazilian literature, when dedicated to recreating contemporary social fractures, has frequently chosen a minimalist perspective in order to counteract the representationalist lineage overly expressed in our tradition. Nowadays, there two writers operating in the minimalist scene and elaborating on the disjunctions of a problematic sociability of a rather impersonal diction in favor of a stylized theater of alterity: André Sant’Anna and Marcelino Freire. The latter, in his modulated short-stories, adopts the rhythms and the assonances of a reduced vocabulary to give form to the situation of marginal characters and, in so doing, he is capable of making them sing. André Sant’Anna, for his part, works through dissonance and seeks to disarrange language by adopting a coordinated syntax, full of repetitions and recurrences. His style causes the tedious effect that underlies the grotesque comicality of certain dictions. Consequently, the examined short-stories, although they offer differences in their conception, practice the rituals of performance, due to their respective efforts to influence reception, as they include elements of reality and equally try to produce literature open to an ethical commitment to life.

  12. Consideraciones sobre el Tratamiento del Modo Subjuntivo en la Gramática de la Lengua Castellana de Andrés Bello

    Directory of Open Access Journals (Sweden)

    Daniel Fernández

    2006-12-01

    Full Text Available Existen estudios que dan cuenta de una tendencia minimalista en algunas de las descripciones estructurales que desarrolla Andrés Bello en su Gramática de la Lengua Castellana (GLC,(Luján 1999, 2000, 2001. Este trabajo informa sobre los resultados obtenidos del análisis del tratamiento que el gramático hace del Modo Subjuntivo en su obra de 1847 con el fin de ver si el perfil minimalista del que habla Luján puede extenderse a otras áreas de su gramática. Concluimos que dada la heterogeneidad de criterios utilizados por Andrés Bello en la descripción de la forma estudiada, resulta dificil definir cuál es el elemento que funciona como núcreo proposicional. En el desarrollo que el gramático realiza, indiscutiblemente lo semántico opera conjuntamente con lo sintáctico y por momentos, parece adquirir más relevancia el tema del significado que el de la forma.

  13. Neurological Impact of World War I on the Artistic Avant-Garde: The Examples of André Breton, Guillaume Apollinaire and Blaise Cendrars.

    Science.gov (United States)

    Bogousslavsky, Julien; Tatu, Laurent

    2016-01-01

    World War I erupted at a time when artistic avant-gardes were particularly thriving across Europe. Young poets, writers, painters and sculptors were called to arms or voluntary enrolled to fight, and several of them died during the conflict. Among others, it dramatically changed their creative output, either through specific wounds or through personal encounters and experiences. These individual events then significantly modified the course of the literary and artistic avant-garde movements. Three particularly illustrative examples of avant-garde French poets are presented here: André Breton (1896-1966), Guillaume Apollinaire (1880-1918) and Blaise Cendrars (1887-1961). The deep source of the surrealist movement can indeed be found in André Breton's involvement as an auxiliary physician with critical interest in neuropsychiatry, which caused him to discover automatic writing. Guillaume Apollinaire's right temporal subdural hematoma strongly modified his emotional state and subsequent artistic activities. Alternatively, after losing his right, writing hand, Blaise Cendrars not only substituted it with a phantom but also rapidly switched from poetry to novels after he learnt to write with his left hand. © 2016 S. Karger AG, Basel.

  14. Development and recent activity of the San Andrés landslide on El Hierro, Canary Islands, Spain

    Science.gov (United States)

    Klimeš, Jan; Yepes, Jorge; Becerril, Laura; Kusák, Michal; Galindo, Inés; Blahut, Jan

    2016-05-01

    Extremely voluminous landslides with a long run-out (also known as megalandslides) on oceanic volcanic islands are infrequent denudational processes on such islands. At the same time, they represent a major geological hazard that must be looked into to avoid negative consequences for the inhabitants of these islands. Their occurrence can be related to periods of intense seismo-volcanic activity, similar to that which occurred on El Hierro Island over 2011-2012. Landslides on volcanic islands are studied using onshore and offshore geological, geophysical and geomorphological records, considering their unique triggering conditions (e.g. lava intrusions, eruptive vents, magma chamber collapses). Previous work has pointed out similarities between specific cases of landslides on volcanic islands and deep-seated gravitational slope deformations (DSGSDs) which are typical in high mountain settings. Nevertheless, the methodological approaches and concepts used to investigate DSGSDs are not commonly applied on volcanic islands studies, even though their use may provide new information about the development stage, recent movements and future hazards. Therefore, this approach for studying the San Andrés landslide (SAL) on El Hierro (Canary Islands) has been developed applying a detailed morphological field mapping, an interpretation of digital elevation models, structural measurements, kinematic testing, and a precise movement monitoring system. The acquired information revealed a strong structural influence on the landslide morphology and the presence of sets of weakened planes acting as the sliding surfaces of the SAL or secondary landslides within its body. The presence of secondary landslides, deep erosive gullies, coastal cliffs and high on-shore relative relief also suggests a high susceptibility to future landslide movement. Direct monitoring on the landslide scarps and the slip plane, performed between February 2013 and July 2014, using an automated optical

  15. 9. veebruaril toimunud kultuuriteaduskonna magistrantide ja doktorantide teaduskonverentsil esinesid ettekannetega Maris Amon, Orest Kormašov, Andres Maamees, Marju Raabe, Siim Sultson ja Merle Talvik. Konverentsi juhatas professor Kaalu Kirme

    Index Scriptorium Estoniae

    2000-01-01

    Kokkuvõtted ettekannetest: Maris Amon. "Eesti Kaitseliidu puhkpilliorkestrite formeerimine ja algusaastad". Orest Kormašov. "Vormimuutused vene ikoonis 17.-19. sajandil". Andres Maamees. "Leenart Neumani muusikakriitiline tegevus". Siim Sultson. "Eesti 1930. aastate väljak - Tartu, Pärnu ja Viljandi". Merle Talvik. "Kunstiliselt kujundatatud dokument 1930. aastail Eestis"

  16. 9. veebruaril toimunud kultuuriteaduskonna magistrantide ja doktorantide teaduskonverentsil esinesid ettekannetega Maris Amon, Orest Kormašov, Andres Maamees, Marju Raabe, Siim Sultson ja Merle Talvik. Konverentsi juhatas professor Kaalu Kirme

    Index Scriptorium Estoniae

    2000-01-01

    Kokkuvõtted ettekannetest: Maris Amon. "Eesti Kaitseliidu puhkpilliorkestrite formeerimine ja algusaastad". Orest Kormašov. "Vormimuutused vene ikoonis 17.-19. sajandil". Andres Maamees. "Leenart Neumani muusikakriitiline tegevus". Marju Raabe. "Kirikutekstiilide ajaloost". Siim Sultson. "Eesti 1930. aastate väljak - Tartu, Pärnu ja Viljandi". Merle Talvik. "Kunstiliselt kujundatatud dokument 1930. aastail Eestis"

  17. Ideologías y actitudes lingüísticas en el Chile del siglo XIX: los reparos de Andrés Bello a las Correcciones lexigráficas de Valentín Gormaz

    Directory of Open Access Journals (Sweden)

    Darío Rojas

    2015-07-01

    Full Text Available Within the studies of objections and comments to dictionaries of provincialisms, this paper analyzes, within a cognitive approach, the linguistic attitudes and ideologies that Andrés Bello show in his commentary to the Correcciones lexigráficas, posthumously published. Bello’s objections to Gormaz exemplify the despair the author felt about the idiomatic poverty among Chilenian writers.

  18. Jõekääru Jazz täitis eesmärgi nii korraldajate, esinejate kui publiku poolelt / Allan Liik, Hedvig Hanson, Andre Maaker, Ain Agan...[jt.] ; foto ja küsitl. Kaire Tensuda

    Index Scriptorium Estoniae

    2007-01-01

    Jõekääru Jazz'ile järgneval nädalal tõi ürituse peakorraldaja Allan Liik toimetusse seal esinenud muusikud. Vestlusringis olid: Allan Liik, Hedvig Hanson, Andre Maaker, Ain Agan, Raivo Tafenau ja Sergio Bastos

  19. Velocidad de descomposición de la hojarasca en diferentes sustratos de manglar en San Andrés Isla, Caribe colombiano

    Directory of Open Access Journals (Sweden)

    Mancera P. José Ernesto

    2007-04-01

    Full Text Available La degradación de la hojarasca de manglar fue estudiada en diferentes sustratos de tres humedales de manglar
    en San Andrés isla, Caribe colombiano. Las tasas de descomposición de Rhizophora mangle (mangle rojo,
    Laguncularia racemosa (mangle blanco y Avicennia germinans (mangle negro fueron medidas en bolsas tipo
    malla. Algunas bolsas fueron dispuestas bajo el suelo, otras sumergidas en el agua, y otras sobre la superficie
    del suelo. Dos humedales del estudio fueron de borde y uno de tipo interno. Algunos factores fisico-químicos que influyen sobre la descomposición de la materia orgánica vegetal fueron evaluados. El modelo de regresión que mejor de ajustó al comportamiento de descomposición fue el simple de raíz cuadrada. La interacción del tiempo con factores bióticos y abióticos determinó la perdida de biomasa foliar. Las mayores tasas de degradación se obtuvieron en humedales de borde; microambientes acuáticos y edáficos húmedos; sobre la especie A. germinans; y en los lugares con macrofauna consumidora asociada. En las etapas tempranas de descomposición
    se presentó la mayor velocidad de degradación. En general, el menor porcentaje medio de biomasa remanente después de seis semanas de incubación lo presentó A. germinans (35%, respecto a R. mangle (44% y L. racemosa (51%. La pedogénesis en San Andrés isla es autóctona, y reconocer el aporte de la necromasa
    foliar del manglar en la acumulación de sedimentos es indispensable para estimar la estabilidad de los habitats costeros frente a los cambios del nivel del mar e impactos ocasionados por eventuales disturbios naturales. Con base a los resultados obtenidos y aquéllos de trabajos previos relacionados con las tasas de productividad de hojarasca en los mismos humedales de estudio, se propone un modelo básico conceptualcuantitativo de la dinámica producción-descomposición de hojarasca en San Andrés isla.

  20. Plaadid / Andre Pichen

    Index Scriptorium Estoniae

    Pichen, Andre

    2006-01-01

    Uutest heliplaatidest Volbeat "The Strength, The Sound, The Songs", Soulwax "Nite Versions", Praful "Pyramid In Your Backyard", Eminem "Curtain Call", "Bossa 'n'' Stones", Mr Oizo "Moustache", Westlife "Face To Face"

  1. At betragte andres krig

    DEFF Research Database (Denmark)

    Krejberg, Kasper Green

    2012-01-01

    Artiklen beskriver to forskellige æstetiske strategier i moderne krigsrepræsentation og deres respektive konsekvenser for forestillinger om krig i den kulturelle erindring. Med eksempler fra anvendelsen af fotografier i to nyere krigsbøger skitseres hhv. en mytologiserende og historiserende...

  2. Kõnnitee kindlusesse / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    1998-01-01

    Arhitektid José Martinez Lapena ja Elias Torres Tur ääristasid siksakina mäekülge mööda Castelldefelsi kindlusse viiva jalakäijaste tee Barcelonas raudbetooni ja sakilise roostevärvi Corten terasega

  3. Andre scener fra Afghanistan

    DEFF Research Database (Denmark)

    Serritzlev, Jeanette

    2010-01-01

    Filmen 'Armadillo' viser, at indsatsen i Afghanistan er formålsløs. At det ikke nytter. At drengene er storforbrugere af cola og porno, og at afghanerne synes, at vi skal tage hjem. At soldaterne har sjove film på deres computere, kan ikke provokere mig. Det kan til gengæld et ensidigt og fortegnet...

  4. Retrofuturistlik tulevik / Andres Lõo

    Index Scriptorium Estoniae

    Lõo, Andres, 1978-

    2012-01-01

    17. septembril NO99 teatris esietendunud kolme teatri - NO99, Münchner Kammerspiele, Lyric Hammersmith Theatre - koostöös valminud lavastusest "Three Kingdoms" ("Kolm kuningriiki"), teksti autor Simon Stephens, lavastaja Sebastian Nübling

  5. Ravikindlustus pensionidelt? / Andres Võrk

    Index Scriptorium Estoniae

    Võrk, Andres, 1974-

    2009-01-01

    Poliitikauuringute keskuse Praxis analüütik on seisukohal, kui pensionide rahastamiseks muid allikaid ei leita ja pensione peab vähendama, siis ei soovitaks ta teha seda 13%-lise vähendamise teel ravikindlustusmaksu nime all, pigem võiks kaaluda pensionide tulumaksustamist. Diagramm

  6. Klounaad paukpadrunitega / Andres Ermel

    Index Scriptorium Estoniae

    Ermel, Andres

    2008-01-01

    Kaksikvendadest näitekirajnikest Peter ja Anthony Shafferist. Viimase menunäidendist "Nuuskur" ("Sleuth") ja selle järgi 1972. a. Joseph L. Mankewiczi poolt tehtud filmist ning Kenneth Branaghi 2007. a. uusversioonist lühidalt

  7. DVD / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Kolme USA mängufilmi DVD-de lühitutvustused : Spike Lee "Keegi seestpoolt" ("Inside Man"), Jonathan Liebesmani "Texase mootorsaemõrvad: Algus" ("The Texas Chainsaw Massacre : The Beginning"), Allen Coulteri "Hollywoodland"

  8. Parandage finantstee! / Andres Velasco

    Index Scriptorium Estoniae

    Velasco, Andres

    2001-01-01

    Harvardi ülikooli juures tegutseva Kennedy valitsuskooli majandusprof. väidab, et rahvusvaheline finantssüsteem pankrotistab keskmise sissetulekuga riike. Majanduskriisis Argentina kaks võimalust. Majanduskriisi põhjused

  9. Objekt 2011 / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2011-01-01

    Installatsioon "Objekt nr. 2011" Tallinnas Vabaduse väljakul 27.02.-20.03.2011. Austria arhitektide rühmituse Haus-Rucker-Co installatsioon "Oaasi nr. 7" 5. Documenta näitusel Kasselis 1972. aastal

  10. Arvustused / Andres Põllu

    Index Scriptorium Estoniae

    Põllu, Andres

    2000-01-01

    Uute heliplaatide Eric Clapton & B.B. King, B. B. "Riding with the King", Dreamphish "It Is I", Deftones "White Pony", Einstürzende Neubauten "Silence Is Sexy", Steve Earle "Transcendental Blues", The Filth And The Fury - A Sex Pistols Film, Cafe Del Mar tutvustus

  11. Antropoloogiline Holland / Andres Kõnno

    Index Scriptorium Estoniae

    Kõnno, Andres

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivali filme - Hollandi mängufilmid "Putini ema" ("Poetin's Mama") : režissöör Ineke Smits : 2003 ; "Shouf-Shouf Habibi" : režissöör Albert Ter Heerdt : 2004 ; "Üks ilus päev" ("Het is een schone dag geweest") : režissöör Jos de Putter : 1993 ; "Grimm" : režissöör Alex van Warmerdam : 2003

  12. Sydafrika og de andre

    DEFF Research Database (Denmark)

    Mandrup Jørgensen, Thomas

    2003-01-01

    Det ny Sydafrika er nu små ti år efter afslutningen på apartheid blevet den måske mest indflydelsesrige stat i Afrika syd for Sahara. Landet har været ledende i processen omkring dannelsen af den Afrikanske Union og en af hovedkræfterne bag NEPAD-programmet. Internationalt har regeringen i Pretoria...

  13. Julgus kahelda / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2004-01-01

    Okupatsioonide muuseumist, 7. "Europani" arhitektuurikonkursil äramärgitud tööst "Alvar" (autoreiks Londonis töötavad arhitektid Eike Sindlinger, Ulrike Steven, Gareth Morris büroost 7-degrees), mis püüab positiivselt sekkuda Tallinna Lasnamäe praegusesse hoonestusse, võimalustest teha sotsiaalselt tundlikku arhitektuuri

  14. Kohtumine Oslos / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2009-01-01

    Autor kommenteerib Oslos toimunud Tšetšeenia eksiilvalitsuse juhi Ahmed Zakajevi ning praeguse Tšetšeenia valitseja Ramzan Kadõrovi esindaja ja parlamendijuhi Duhhvahha Abdurahmanovi kohtumist. Versioonid tulevikuks

  15. Actividad poltergeist y el caso “Andrés Venier”: Algunas consideraciones neuropsicológicas, fenomenológicas y psicodinámicas / Poltergeist activity and Andrés Venier's case: some phenomenological, neuropsychological, and psychodynamical issuess

    OpenAIRE

    Parra, Alejandro; Universidad Abierta Interamericana (Argentina)

    2005-01-01

    En este artículo el autor plantea la fenomenología, neuropsicología y psicodinámica en torno a la actividad poltergeist, con particular énfasis en el caso del joven Andrés Venier, de Río Tercero, en la provincia de Córdoba, Argentina. El fenómeno parece estar ocasionado por psicokinesis (influencia de la mente sobre la materia) a nivel inconsciente. Estos eventos se vienen reportando desde la Antigüedad. Su fenomenología es descrita en términos de lanzamientos y desplazamientos de objetos, ru...

  16. Patrones ontogénicos y estacionales de peces arrecifales según el uso de hábitat en San Andrés, Caribe insular colombiano / Ontogenetic and seasonal patterns of reef fishes according to use of habitat in San Andres, insular Colombian Caribbean

    OpenAIRE

    Sierra Rozo, Omar

    2010-01-01

    La presente investigación1, basada en la teoría de la conectividad ecosistémica, estudió los enlaces ecológicos entre manglares, pastos marinos y arrecifes de coral en San Andrés Isla (Reserva de Biosfera Seaflower-RBS), para reconocer y cuantificar la relevancia de la interacción ecosistémica respecto a la ictiofauna local y para determinar cuáles especies dependen de manglares y praderas durante su ontogenia. Se seleccionaron sitios donde los arrecifes están próximos a manglares...

  17. [Knowledge on drugs phenomenon by students and faculty from the Medical School at Universidad Mayor de San Andrés, La Paz, Bolivia].

    Science.gov (United States)

    Navia-Bueno, Maria del Pilar; Farah-Bravo, Jacqueline; Yaksic-Feraudy, Nina; Philco-Lima, Patrícia; Takayanagui, Angela Maria Magosso

    2011-06-01

    The goal of this study was to identify the degree of knowledge of students and health educators on licit and illicit drugs, related to the type, classification, action, mechanisms damages, consequences and adverse effects, besides use and consumption. A cross-sectional methodological design was used, with a sample of 172 students, professors and residents in medicine and nursing at Universidad Mayor de San Andrés (UMSA), Bolivia. The results reveal weak knowledge on the classification of psychotropic substances according to structure, chemical property and effects for health, highlighting significant difference with knowledge on licit and illicit drugs use, with high percentages. In conclusion, there is lack of knowledge in all groups studied on licit and illicit drugs regarding the consequences and adverse effects. This confirms the need to improve teaching on this content in health schools.

  18. El problema moral de la obra de arte en El inmoralista de André Gide y su posible explicación hermenéutico-existencial

    Directory of Open Access Journals (Sweden)

    Germán Darío Vélez

    2012-11-01

    Full Text Available Imponiéndose una estricta moral del cuidado de sí, un hombre consigue escapar a una enfermedad mortal. Los principios de la cura personal son convertidos por él en doctrina. El rigor de esa doctrina acaba con la vida de su esposa. Abandonado a sí mismo y a sus remordimientos, pide socorro a sus amigos...… Este es el argumento de El inmoralista, de André Gide, y del problema mayor de la ética que plantea: ¿cómo apropiarse de sí sin perder al otro? Mediante una lectura hermenéutico-existencial de esta obra, el presente artículo plantea un análisis y una explicación de esta paradoja.

  19. André Raymond, Égyptiens et Français au Caire, 1798-1801, Le Caire, IFAO, 1998, 391 p.

    Directory of Open Access Journals (Sweden)

    Jean-Charles Depaule

    2005-03-01

    Full Text Available La Description établie par les savants que Bonaparte avait emmenés en Égypte offre, on le sait, un riche tableau, d'autant plus précieux qu'il fixe un moment charnière : dans les décennies qui suivront le pays entrera dans une ère nouvelle, celle de sa "modernisation" et de la construction d'un État progressivement indépendant. Procédant par coupes, la vision de la Description était statique. André Raymond, dès le premier chapitre de son livre, anime en quelque sorte le monde enregistré par l...

  20. Kas hirmul külma sõja ees on alust? / George Soros, Martti Ahtisaari, Toomas Hendrik Ilves...[jt.] ; interv. Andres Kasekamp

    Index Scriptorium Estoniae

    2008-01-01

    6. novembril 2008 Tallinnas toimunud XIII Avatud Ühiskonna Foorumil alapealkirjaga "Euroopa Liit ja Venemaa: mida toob tulevik?" arutlesid president Toomas Hendrik Ilves, Euroopa Välissuhete Nõukogu aseesimees Martti Ahtisaari, Euroopa Välissuhete Nõukogu liige, Avatud Ühiskonna Instituudi nõukogu esimees George Soros, Euroopa Välissuhete Nõukogu liige, politoloogiaprofessor Aleksander Smolar ja Rahvusvahelise Kaitseuuringute Keskuse juhataja Kadri Liik suhete üle Venemaaga. Vestlust juhtis Andres Kasekamp. President T. H. Ilves rääkis paradigma muutusest Euroopa Liidu ja Venemaa suhetes pärast Venemaa agressiooni Gruusia vastu, ühiselt jagatud väärtustel põhineva julgeolekuorganisatsiooni tähtsusest, autoritaarse ja demokraatliku kapitalismi vastuolust

  1. André Rauch, L’amour à la lumière du crime. 1936-2007, Paris, Hachette Littérature, 2009, 247 p.

    Directory of Open Access Journals (Sweden)

    Odile Goerg

    2010-07-01

    Full Text Available Bien avant que ne se répande la vogue des études sur la masculinité, réponses en miroir à l’énoncé de Simone de Beauvoir « on ne naît pas femme, on le devient », André Rauch s’interrogeait sur ce qui fonde, détermine ou cerne le ‘premier sexe’. Sous des angles variés, et sur deux siècles environ, de la Révolution à nos jours, il poursuit ses interrogations sur le rapport homme-femme, en renouvelant constamment ses approches. Il choisit ici de traiter la question par le biais de ce qu’on appel...

  2. Bedre integration af vind. Analyse af elpatronloven, treledstariffen for mindre kraft-varmeanlæg, afgifter og andre væsentlige rammebetingelser

    DEFF Research Database (Denmark)

    Togeby, Mikael; Werling, Jesper; Hethey, Janos

    er Energistyrelsens og Skatteministeriets udbud (dateret 26.1.2009) og Ea Energianalyse og Risø DTUs projektbeskrivelse (16.2.2009). Arbejdet er gennemført i tæt dialog med en følgegruppe med deltagere fra Energistyrelsen, Skatteministeriet og Energinet.dk. Der har ligeledes været dialog med en række...... markedsaktører, blandt andre elhandlere og energiselskaber. Denne rapport sammenfatter analysen og dens anbefalinger. Herudover er analysen dokumenteret i tre delrapporter, som omhandler en analyse af problemstillingerne vedrørende indpasning af vindkraft, en analyse af de forskellige løsningsmuligheder samt en...... analyse af de samfundsøkonomiske konsekvenser af ændringer i afgifterne....

  3. Laboratorios Andrómaco: Origins of the First Subsidiary of a Spanish Pharmaceutical Multinational in the United States (1928–1946

    Directory of Open Access Journals (Sweden)

    Paloma Fernández Pérez

    2016-07-01

    Full Text Available Laboratorios Andrómaco was a Spanish pharmaceutical company that opened a commercial subsidiary in the United States in the early months of 1929. It was located right in the heart of Manhattan, at 11 West 47th Street, in front of the New York Public Library. Despite the Wall Street crash, it remained open until 1946. The owner was the pharmacist-entrepreneur Fernando Rubió Tudurí (1900–1994. It was the first foreign direct investment made by a Spanish pharmaceutical multinational in the United States, using a maquila-style operation to export Spanish products made in the USA to Central American markets. Nothing has been published about this until now. Only interviews with Enrique and Mercè Rubió Boada (son and daughter of Fernando Rubió, digitalized sources from the company held by the Fundació Rubió Tudurí in Mahón, Minorca, and hard-to-access secondary sources have made the recovery of this history possible. The company closed its doors in the US and expanded in South American markets after World War II, but the short history of their investment in the United States reveals the potential and international capabilities of Spanish pharmaceutical companies before the Spanish Civil War. Moreover, it reveals how the Spanish Civil War was a disaster for millions of people but in some special cases it became an opportunity for companies in the science industries. Few pharmaceutical firms like Andrómaco, with entrepreneurs, resources, and a long-term vision, took the decision to invest in the most profitable (though also the most difficult market for pharmaceutical products in the world: the United States. Andrómaco was created in Barcelona in 1923 by two scientist-entrepreneurs (Raul Roviralta and Fernando Rubió Tudurí. A nutritional product called Glefina (made with Norwegian cod oil from Ålesund and sugar brought the small firm considerable success in sales in Spain in the mid-1920s. Making use of impressive networks (with the

  4. Reading the ideological subtext in André Brink’s An Instant in the Wind and Patrick White’s A Fringe of Leaves

    Directory of Open Access Journals (Sweden)

    M. Wenzel

    2001-08-01

    Full Text Available From a postcolonial perspective, the simultaneous publication of André Brink’s An Instant in the Wind and Patrick White’s A Fringe of Leaves provides an interesting example of rewriting. Although both texts refer to the original story of Eliza Fraser that has featured in several genres, they approach the event from different historical time-frames. This article attempts to indicate that the contextual and formal similarities between the two novels are underpinned by different ideological subtexts that clearly manifest the respective authors’ preoccupations and their unconscious reactions to socio-political contexts. It would seem that Brink’s main concern lies with race relations, while White is more engrossed with gender issues.

  5. Identidades ambientales, un caso comparativo entre el Trapecio amazónico y el Archipiélago de San Andrés

    Directory of Open Access Journals (Sweden)

    Pablo De La Cruz

    2014-01-01

    Full Text Available A partir de la definición de identidad ambiental, el artículo compara los procesos de transformación identitaria que han tenido lugar en el Trapecio amazónico colombiano y en el Archipiélago de San Andrés, por cuanto son dos casos de redefinición histórica de la etnicidad con referencia al medio geográfico, al encuentro con la colombianidad, a la agudización del discurso y a las tensiones que los capitales y los agentes institucionales generan en torno a lo tradicional. Se analiza el creciente turismo, la influencia de las agencias de cooperación y sus efectos en el desplazamiento de lo sagrado hacia una “cultura teatral”.

  6. Notes to the recent reissue of the book Poems of the mothers of Gabriela Mistral With illustrations by André Racz

    Directory of Open Access Journals (Sweden)

    Mónica R. Ravelo García

    2017-04-01

    Full Text Available The book The Mothers’ Poems, combining the verses of Gabriela Mistral and drawings of the artist Andre Racz, has been reissued by Ediciones Radio Universidad de Chile with the support of the National Council for Culture and the Arts (CNCA of the Government of Chile in 2015. This is the third edition of the poems and the second in which Racz’s images are included, since it was published for first time in 1950. The theme of motherhood, women, fears and strengths are masterfully described by a woman who could never conceive but devotedly loved children and empathized with women. With such delivery, with his strokes Racz described the delicate and sensitive world of the pregnant woman. Both artists joined in the realization of this book as an expression of love and human solidarity.

  7. «Une sainte infidélité» : Proposition pour une politique de la traduction à partir d’André du Bouchet

    Directory of Open Access Journals (Sweden)

    Paul Laborde

    2010-01-01

    Full Text Available André du Bouchet’s work as a translator is in continuity with the one he does as a poet. Starting from some perspectives opened by his poetic practice, we will tempt to bring out a vision of translation that could enlighten the kind of relation the poet maintains with the language alterity Then, it is the wider horizon of the relationship to poetry which is modified. We hope to underline the ethical and political (in a wide sense consequences of such a position – notably by establishing a thinking of dialogue. The derridian concept of differance, the deleuzian semiotic and the hölderlinian thematic of the native reversal will mark out our course of thinking, like so many perspectives and lightening.

  8. Contextos de uso de la lengua española entre la población raizal de la isla de San Andrés Colombia

    OpenAIRE

    Ávila Mora, Marlen

    2014-01-01

    Este trabajo final llevado a cabo desde una mirada sociolingüística y etnográfica da a conocer los resultados obtenidos sobre las condiciones en las cuales se adquiere y usa la lengua española entre la población raizal de la isla de San Andrés, además analiza los contextos de uso y las percepciones y valoraciones de los hablantes en este espacio de contacto lingüístico. A través de la observación directa, la participación en los distintos espacios de recreación de las lenguas habladas y la ap...

  9. Andrés del Río, Antonio del Castillo y José G. Aguilera en el desarrollo de la ciencia mexicana del siglo XIX

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    Uribe Salas, José Alfredo

    2006-08-01

    Full Text Available This article analyzes the intrinsic relation between education and science in the process of institutionalization of mineralogy and geology in nineteenth-century Mexico. It focuses on the intellectual leadership of three men of sciences in the modernization and professionalization of geology’s curricula. These were: Andrés Manuel del Río, Antonio del Castillo y José G. Aguilera. The work of these men represents the human foundation of the process of institutionalization and professionalization of Earth Sciences in Mexico: from the Royal Mining Seminar, to the Mining School and the National School of Engineering, to the National Institute of Geology, the latter the immediate antecedent of the modern Institute of Geology at the National Autonomous University of Mexico (UNAM.

    En el artículo se analiza la relación intrínseca entre educación y ciencia en el proceso de institucionalización de la mineralogía y la geología en México del siglo XIX. Destacamos el liderazgo intelectual de tres hombres de ciencia que desempeñaron un esfuerzo articulador en la modernización de los planes de estudio y profesionalización de la geología mexicana. Ellos son: Andrés Manuel del Río, Antonio del Castillo y José G. Aguilera. El trabajo de estos tres hombres representa el soporte humano del proceso de institucionalización y profesionalización de las Ciencias de la Tierra, primero a través del Real Seminario de Minería, pasando por la Escuela de Minería y la Escuela Nacional de Ingenieros, para terminar en el Instituto de Geológico Nacional, antecedente directo del actual Instituto de Geología de la Universidad Nacional Autónoma de México.

  10. Corrupción y regeneración: Víctor Andrés Belaunde y «La crisis presente»

    Directory of Open Access Journals (Sweden)

    Santiváñez Vivanco, Martín

    2014-04-01

    Full Text Available Víctor Andrés Belaunde, one of the most relevant thinkers of Latin American Arielism, held that it was necessary to combine institutional design with a regeneration of values, as a solution to the political crisis that Peru was experiencing. Thus, the combination of institutional design and axiological or ethical vitalism created a holistic approach that introduced into the public debate a vision of integral development in which the fight against corruption and institutional problems could be addressed, in a complementary way, from an ethical perspective. This dimension served to strengthen the construction of an inclusive State, one of the political objectives of the Arielian generation.Víctor Andrés Belaunde, uno de los pensadores más relevantes del arielismo latinoamericano, sostuvo la necesidad de combinar el diseño institucional con una regeneración valorativa como remedio a la crisis política que atravesaba el Perú. Así, la combinación de diseño institucional y vitalismo axiológico configuró un enfoque sintético que introdujo en la discusión pública una visión de desarrollo integral en el que la lucha contra la corrupción y los problemas institucionales podían ser abordados, de manera complementaria, desde una perspectiva ética. Tal dimensión servía para fortalecer la construcción de un Estado inclusivo, uno de los objetivos políticos de la generación arielista.

  11. Resonances in pi-K scattering

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, David J. [Old Dominion University, Norfolk, VA

    2014-06-23

    We have obtained clear signals of resonances in coupled-channel pi K - eta K scattering. Using distillation and a large basis of operators we are able to extract a precise spectrum of energy levels using the variational method. These energies are analysed using inelastic extensions of the Luescher method to obtain scattering amplitudes that clearly describe S, P and D wave resonances, corresponding to the physical K_0^*(1430), the K^*(892) and the K_2^*(1430).

  12. Haṭhapradīpikā

    DEFF Research Database (Denmark)

    Olesen, Bjarne Wernicke; Einarsen, Silje Lyngar; , .

    ), prāṇāyāma (åndedrætsteknikker), mudrā (yogiske teknikker) og samādhi (meditative indsigter). Dertil er HYP et encyklopædisk værk (formodentligt sammensat af mere end 20 forskellige yogaskrifter) fra haṭhayogaens klassisk-formative fase, hvorfor værket tillige udgør en forståelsesnøgle til yoga, tantra og...

  13. The last versification of Jovellanos« El delincuente honrado»: a literary controversy by Andrés Muriel during the decline of Neoclasicism La última versificación de «El delincuente honrado» de Jovellanos: una polémica literaria de Andrés Muriel en el ocaso del neoclasicismo

    Directory of Open Access Journals (Sweden)

    Antonio CALVO MATURANA

    2012-01-01

    Full Text Available This essay analyzes the details of an almost unknown literary controversy: the one that confroted Andrés Muriel and José González de la Cruz (with the secretary of State Mariano Urquijo as arbitrator in 1800. González dared to versity the famous Jovellanos play El delincuente honrado, a nerved that Muriel (a young university professor considered an attack against Neoclassic precepto (prevailing in those days.Este artículo recoge los entresijos de una polémica literaria apenas conocida, la que enfrentó a Andrés Muriel con José González de Cruz y con el secretario de Estado Mariano Urquijo como árbitro en 1800. González se había atrevido a versificar la famosa obra de Jovellanos El delincuente honrado, lo que a Muriel (entonces un joven profesor universitario le pareció un atentado contra las ideas neoclásicas entonces imperantes.

  14. Vigencia de la filosofía de Kant en dos expresiones actuales de la inteligencia filosófica en América Latina: Arturo Andrés Roig y Franz J. Hinkelammert The Force of Kant's Philosophy in Two Present Expressions of the Philosophical Intelligence in Latin America: Arturo Andrés Roig y Franz J. Hinkelammert

    Directory of Open Access Journals (Sweden)

    Yamandú Acosta

    2006-12-01

    Full Text Available Al cumplirse doscientos años de la muerte de Immanuel Kant 2004, considerar la vigencia de su pensamiento filosófico, se constituyó en un imperativo categórico, para quienes nos inscribimos en la tradición de la filosofía occidental. En cumplimiento del mismo, el texto que se presenta se ocupa de la vigencia de la filosofía del filósofo de Königsberg a través de la consideración de dos expresiones de la inteligencia filosófica en América Latina: Arturo Andrés Roig (Mendoza, Argentina, 1922 y Franz J. Hinkelammert (Emsdetten, Alemania,1931. Los programas de investigación en curso de los dos autores elegidos, en el abordaje y desarrollo de distintos tópicos, proceden argumentativamente desde, contra y más allá de Kant, exhibiendo una singular vigencia de su filosofía al interior de los mismos. En el pensamiento de Arturo Andrés Roig, los tópicos de referencia que se consideran son: la normatividad del pensamiento filosófico, la filosofía de la historia, la fundamentación de una moral emergente y la fundamentación de una estética motivacional. De la producción teórica de Franz J. Hinkelammert, se presentan: la crítica a la razón utópica y el realismo político, la crítica trascendental de los marcos categoriales de los pensamientos sociales, la trascendentalidad del sujeto y el problema del universalismo ético en la tensión entre la ética de la responsabilidad y la ética de principios. Surge de la consideración de los asuntos enumerados, que en relación al universalismo abstracto de Kant, estos dos exponentes de la inteligencia filosófica en América Latina, convergen en la fundamentación de un universalismo concreto.Currency of Kant's philosophy in two recent expressions of the philosophical intelligence in Latin America: Arturo Andrés Roig and Franz J. Hinkelammert. When it is twohundred years of Immanuel Kant´s death (2004, to consider the currency of his philosophical thought means a categorial must

  15. El mito de Andrómeda y Perseo en la historia de la ópera : Jean-Baptiste Lully (1632-1687), Johann Michael Haydn (1737-1806), Jacques Ibert (1890-1962) y Salvatore Sciarrino (1947)

    OpenAIRE

    Cerezo Sánchez, Rosario

    2016-01-01

    OBJETIVOS: Esta tesis se enmarca en el ámbito de la Pervivencia de la Mitología Clásica y el objetivo es investigar sobre el tratamiento e influencia que la leyenda de Andrómeda y Perseo ha tenido a lo largo de tres periodos histórico-musicales en la ópera: barroco, clasicismo y siglo XX. El origen de este trabajo es la lectura de la leyenda de Andrómeda y Perseo en la versión canónica de Ovidio en las Metamorfosis, 4.604-803 y 5.1-235. Nuestro objetivo es examinar la proyección de ...

  16. Kogukond on partner kohaliku elu korraldamisel : Veebruari lõpus esitlesid Linnalabor ja külaliikumine Kodukant uuringut "Eesti kogukondade hetkeseis" / Andrus Saliste, Triin Lääne, Andres Laisk ... [jt.] ; intervjueerinud Madle Lippus

    Index Scriptorium Estoniae

    2015-01-01

    Uuringuga püüti välja selgitada geograafilisi kogukondi - nende toimimist, ülesehitust ja tegutsemise takistusi. Uuringu esitlusele järgnenud arutelul said sõna Andrus Saliste Muraste külaseltsist, Triin Lääne Tartumaa arendusseltsist (sealne Leaderi tegevusrühm), Saue vallavanem Andres Laisk ja Marten Lauri siseministeeriumist. Vestlust vedasid uuringu korraldajad Peeter Vihma ja Madle Lippus

  17. Identificación de mutaciones en el gen para el receptor de andrógenos por medio de la técnica SSCP en pacientes con insensibilidad androgénica completa

    Directory of Open Access Journals (Sweden)

    Gutiérrez A.

    2001-06-01

    Full Text Available El Síndrome de Insensibilidad Androgénica (SIA es causado por defectos del gen para elReceptor de Andrógenos (RA, el síndrome presenta 3 fenotipos: Completa (SIAC, el fenotipoes femenino, Parcial (SIAP donde se puede presentar ambigüedad genital y Mínima (SIAMque se presenta con infertilidad en pacientes con fenotipo masculino.

  18. Epidemiología de la enfermedad de Chagas en el municipio Andrés Eloy Blanco, Lara, Venezuela: infestación triatomínica y seroprevalencia en humanos Epidemiology of Chagas disease in Andrés Eloy Blanco, Lara, Venezuela: triatomine infestation and human seroprevalence

    Directory of Open Access Journals (Sweden)

    Claudina Rodríguez-Bonfante

    2007-05-01

    Full Text Available Se realizó un despistaje serológico y recolección de vectores en cuatro comunidades rurales del municipio Andrés Eloy Blanco, Estado Lara, Venezuela. La muestra fue escogida en forma sistemática y aleatoria basada en conglomerados familiares. Se muestrearon 869 habitantes para determinar anticuerpos anti-Trypanosoma cruzi y anti-Leishmania sp. por inmunofluorescencia indirecta, aceptando como positivo diluciones > a 1:32 para anticuerpos anti-T. cruzi no reactivos para antígenos de Leishmania sp., obteniendo una frecuencia de anticuerpos en la muestra de 6,9% (n = 60; de los cuales 46,66% son femeninos, 53,33% masculinos y 60% mayores de 40 años. Se observó que 5 (8,33% de los seropositivos eran menores de 10 años y 10 (16,66% menores de 20 años. Rhodnius prolixus y Panstrongylus geniculatus fueron los triatominos capturados, con índice de infestación de 1,9 y 10,54%, índice de colonización, del 0 y 18,18% en las viviendas infestadas e índice de infección a T. cruzi del 20 y 5,07%, respectivamente. Los resultados sugieren que existe una transmisión activa de la enfermedad de Chagas en el Municipio Andrés Eloy Blanco en las últimas dos décadas y que P. geniculatus está substituyendo a R. prolixus como vector de la enfermedad de Chagas.A seroepidemiological survey and vector captures were performed in four rural communities in Andrés Eloy Blanco, Lara State, Venezuela. Systematic random sampling was based on family clusters, with samples drawn from 869 individuals to determine anti-Trypanosoma cruzi and anti-Leishmania sp. antibodies by indirect immunofluorescence. Positive individuals were defined as > 1:32 for anti-T. cruzi antibody and non-reactive to Leishmania sp. antigen, revealing an antibody frequency of 6.9% (n = 60, of whom 46.66% were females and 53.33% males and 60% were over 39 years of age. Some 5 (8.33% seropositive individuals were under 10 years of age and 10 (16.66% under 20 years. Rhodnius prolixus and

  19. O Ateísmo Francês Contemporâneo: uma comparação crítica entre Michel Onfray e André Compte-Sponville (Contemporary French Atheism: a Critical Comparison between Michel Onfray and André Comte-Sponville) - DOI: 10.5752/P.2175-5841.2010v8n18p127

    OpenAIRE

    Agnaldo Cuoco Portugal; Abraão Lincoln Ferreria Costa

    2011-01-01

    Michel Onfray e André Comte-Sponville são os dois mais famosos representantes do ateísmo filosófico francês contemporâneo, que continua uma tradição iniciada no século XVIII de negação irreligiosa da noção monoteísta de Deus. Embora compartilhando várias ideias, como o naturalismo e, obviamente, a rejeição do monoteísmo, suas propostas têm diferenças importantes. Onfray imputa à religião a maioria dos males enfrentados pela humanidade, recusando-se a fazer qualquer concessão à tradição religi...

  20. Vigencia de la filosofía de Kant en dos expresiones actuales de la inteligencia filosófica en América Latina: Arturo Andrés Roig y Franz J. Hinkelammert The Force of Kant's Philosophy in Two Present Expressions of the Philosophical Intelligence in Latin America: Arturo Andrés Roig y Franz J. Hinkelammert

    OpenAIRE

    Yamandú Acosta

    2006-01-01

    Al cumplirse doscientos años de la muerte de Immanuel Kant 2004), considerar la vigencia de su pensamiento filosófico, se constituyó en un imperativo categórico, para quienes nos inscribimos en la tradición de la filosofía occidental. En cumplimiento del mismo, el texto que se presenta se ocupa de la vigencia de la filosofía del filósofo de Königsberg a través de la consideración de dos expresiones de la inteligencia filosófica en América Latina: Arturo Andrés Roig (Mendoza, Argentina, 1922) ...

  1. Narcotráfico, violencia y crisis social en el Caribe insular colombiano: El caso de la isla de San Andrés en el contexto del Gran Caribe Drug Traffiking, Violence and the Social Crisis in Colombian Caribbean Islands: The Case of San Andrés Island in the Context of the Great Caribbean

    Directory of Open Access Journals (Sweden)

    Silvia Mantilla

    2011-06-01

    Full Text Available El presente artículo tiene por objetivo presentar un diagnóstico preliminar de la magnitud del tráfico de drogas, sus dinámicas, modalidades, y las condiciones sociales y económicas que favorecen el desarrollo de este negocio ilegal en la isla de San Andrés (Colombia. El análisis se desarrolla, no obstante, en el marco de la condición histórica y natural de "zona de tránsito" de drogas, armas y otros recursos ilegales, que se le atribuye a la región del Gran Caribe, entendida como un continuo geográfico, histórico y cultural en el que se observan patrones comunes en materia de amenazas a la seguridad, la geopolítica de las relaciones con Estados Unidos y los efectos sociales y económicos derivados del flagelo del narcotráfico. En este sentido, el caso de la isla de San Andrés (Colombia se examina más como parte de la dinámica insular gran caribeña que como parte de las tendencias propias del negocio en la Colombia continental, lo que permite, sin embargo, establecer las conexiones entre ambos espacios regionales -el insular y el continental- y, a la vez, evaluar el impacto regional del fenómeno a partir de las conexiones ilegales que desde el archipiélago se establecen con algunos países vecinos del Gran Caribe. Finalmente, se sostiene la hipótesis de que el fenómeno del narcotráfico se instala en la isla como resultado de factores geohistóricos, culturales y socioeconómicos que en conjunto han determinado la participación activa de distintos sectores de la sociedad en este negocio ilegal.The objective of thispaper is to present a preliminary diagnosis of the magnitude, dynamics, and modalities of drug trafficking, together with the social and economic conditions that support the development of this illegal activity in the island of San Andres (Colombia. Analysis is conducted within a framework that identifies this trafficking zone as a natural and historic corridor for trade in weapons, drugs, and other illicit

  2. El "concierto sacro" del 19 de abril de 1810: 0 la conjura eclesiástica de Andrés Bello (1781-1865 The "Sacred Contriving" of April 19th, 1810: or the Ecclesiastical Conspiracy of Andrés Bello (1781-1865

    Directory of Open Access Journals (Sweden)

    David Coifman Michailos

    2012-06-01

    Full Text Available El concierto sacro delJueves Santo, 19 de abril de 1810, marcó el inicio del movimiento independentista de Venezuela. La fecha no fue escogida al azar, sino que a propósito de las ventajas que la "función eclesiástica" de ese día proporcionaba para el control social y la difusión de la información en torno a los hechos políticos que se buscaba alcanzar. El presente ensayo se propone examinar la confluencia musical y eclesiástica (hasta ahora no estudiada que habría sin duda sido necesaria establecer para el positivo resultado de esta empresa, supeditada a las redes sociales, musicales e intelectuales en torno al editor entonces de la Gazeta de Caracas, hijo del músico y abogado Bartolomé Bello (1758-1804, el humanista Andrés Bello (1781-1865.The sacred contriving on Maundy Thursday, April 19th, 1810, marked the beginning of the independence of Venezuela. The date was not chosen at random but on the basis ofthe advantages that the "ecclesiasticalfunction" had regarding both the social control and the dissemination ofthe information about the political goals to be achieved. The purpose ofthis essay is the analysis ofthe hitherto unknown confluence ofthe musical and ecclesiastical elements that made it possible this enterprise to succeed. These elements in turn are related to the social, intellectual and musical networks ofthe humanist Andrés Bello (1781-1865, editor ofthe Gazeta de Caracas and son ofthe musician and lawyer Bartolomé Bello (1758-1804.

  3. Proyecto de un servicio funcional a prestar en una biblioteca universitaria: “El Servicio de Información Departamental” de la Biblioteca Max von Buch (Universidad de San Andrés = Project of a functional service to be provided in an university library: "The Departmental Information Service" of the Max von Buch Library (Universidad de San Andrés

    Directory of Open Access Journals (Sweden)

    Moira Guppy

    2001-06-01

    Full Text Available Este trabajo –elaborado para el Seminario “La organización de los Servicios al Público en la Biblioteca” (UBA, 1998- describe el proyecto de un servicio a desarrollar en la Biblioteca Max von Buch de la Universidad de San Andrés. El “Servicio de Información Departamental” ofrecerá a los docentes e investigadores acceso a los recursos disponibles dentro de su área temática (Internet, bases de datos, índices de artículos de publicaciones periódicas, revistas en texto completo, series estadísticas, etc. Estará elaborado en dos formatos: un cd-rom actualizado periódicamente, y una página Web en línea especialmente diseñada. Con la implementación de este servicio se logrará un gran ahorro de tiempo en la búsqueda, análisis, tratamiento y difusión de la información destinada a la investigación académica = This paper –presented at the seminary “Public Services Organization at the Library”- describes a project to be developed at the Max von Buch Library, Universidad de San Andrés. The “Academic Information Service” would be design to provide access to researchers and faculty to all the resources available whithin each discipline and research area in the Internet, databases, periodical indexes, full text periodicals, statistical data, etc. They will gain access to it from a cd-rom which would be updated periodically, and a web page specially designed. The implementation of this project would provide faculty with qualified information along with considerable time saving in their researches.

  4. Variación espacial de la comunidad macroinfaunal de praderas de pastos marinos de San Andrés Isla, Caribe colombiano

    Directory of Open Access Journals (Sweden)

    Campos Néstor

    2006-06-01

    Full Text Available Se estudió la distribución espacial de la macroinfauna asociada a pastos marinos de las bahías Hooker,
    Honda y Sea Horse de la isla de San Andrés (Caribe colombiano, en época seca. Se tomaron muestras de
    sutrato en tres rangos de profundidad (0-2, 2-5 y >5m en cada bahía para un total de nueve estaciones. Se compararon las características estructurales de cada estación, encontrando bajas densidades promedio
    (187 ind/m2. Por medio de análisis de clasificación y la técnica de ordenación NMDS, a partir de las abundancias a nivel de familia, se definieron cuatro grupos. La distribución espacial de estos grupos indica que forman parte de una misma comunidad con amplia variación espacial en su composición y estructura. Los efectos generados por la corriente superficial y por la heterogeneidad estructural del hábitat son propuestos como posibles causas de la variación de la comunidad.

  5. Monsters and the case of L. Joseph: André Feil's thesis on the origin of the Klippel-Feil syndrome and a social transformation of medicine.

    Science.gov (United States)

    Belykh, Evgenii; Malik, Kashif; Simoneau, Isabelle; Yagmurlu, Kaan; Lei, Ting; Cavalcanti, Daniel D; Byvaltsev, Vadim A; Theodore, Nicholas; Preul, Mark C

    2016-07-01

    André Feil (1884-1955) was a French physician best recognized for his description, coauthored with Maurice Klippel, of patients with congenital fusion of cervical vertebrae, a condition currently known as Klippel-Feil syndrome. However, little is known about his background aside from the fact that he was a student of Klippel and a physician who took a keen interest in describing congenital anomalies. Despite the relative lack of information on Feil, his contributions to the fields of spinal disease and teratology extended far beyond science to play an integral role in changing the misguided perception shrouding patients with disfigurements, defects, deformities, and so-called monstrous births. In particular, Feil's 1919 medical school thesis on cervical abnormalities was a critical publication in defying long-held theory and opinion that human "monstrosities," anomalies, developmental abnormalities, and altered congenital physicality were a consequence of sinful behavior or a reversion to a primitive state. Indeed, his thesis on a spinal deformity centering on his patient, L. Joseph, was at the vanguard for a new view of a patient as nothing less than fully human, no matter his or her physicality or appearance.

  6. Remediation Technology of Contaminated Areas with Organochlorines: A Preliminary Evaluation Seeking Potential Applications on the Site of Street Capua, Santo André - SP

    Directory of Open Access Journals (Sweden)

    Mauro Silva Ruiz

    2012-12-01

    Full Text Available This paper is aimed to analyze the use of remediation technologies for areas contaminated with organochlorine based on a literature review and discussions with specialists. The remediation technologies analyzed were bioremediation, phytoremediation, nanotechnology, chemical oxidation, and thermal desorption. The purpose is to identify and compare “key problems” for each of these technologies envisaging the use of one or more of these them f or the remediation of the Capua Street site in Santo André, SP. Four databases were used in the preliminary literature review: Scopus, SciELO, Web of Science, and Science Direct. A survey questionnaire was designed to gather information on publications of scientific papers and patents, specific uses of these technologies by companies, and cases of application. Since the quality of the data and information obtained from this questionnaire application was not satisfactory, a new research approach for complementing them was undertaken. For this purpose, the Web of Science was selected as the most adequate data basis to carry out this second survey. However, it was realized that even for this database - that is reference for evaluating academic institutions, researchers and maturity of technologies – bias coming from the original data source can affect the survey results. Moreover, as the number of keywords used in the research consisted of generic terms for each technology, it can also be assumed that if some authors have used very specific terms, a small amount of work published by them would possibly have been misrepresented in the final result.

  7. Afrikaans as 'n komplekse netwerk: Die woordko-voorkomsnetwerke van woorde in André P. Brink se Donkermaan in Afrikaans, Nederlands en Engels

    Directory of Open Access Journals (Sweden)

    Burgert A. Senekal

    2016-02-01

    Full Text Available Taal word reeds sedert De Saussure as ’n sisteem benader, en onlangs is die teorie van komplekse sisteme ook binne die taalkunde toegepas. Komplekse sisteme kan egter ook as komplekse netwerke gemodelleer word, en daar is reeds ’n verskeidenheid studies in die buiteland onderneem wat ondersoek instel na die netwerkstruktuur van taal. Die huidige studie volg in die voetspoor van oorsese studies en ondersoek die netwerkstruktuur van Afrikaans deur ’n woordko-voorkomsnetwerk te ontleed, soos saamgestel uit André P. Brink se roman Donkermaan. Skakelverspreidingspatrone en die kleinwêreldfenomeen word ondersoek en vergelyk met die Engelse en Nederlandse vertalings van dié roman. Die huidige studie verteenwoordig die eerste netwerkstudie in Afrikaans, en maak eerstens gebruik van Erdös en Rényi se lukrake netwerkmodel, sowel as Barabási en Albert se skaalvrye netwerkmodel, om aan te toon dat die skakelverspreidingspatrone in ’n woordko-voorkomsnetwerk van Afrikaans beter volgens Barabási en Albert as volgens Erdös en Rényi se netwerkmodel beskryf word. Verder word gebruik gemaak van die metode soos voorgestel in Humphreys en Gurney om kleinwêreldsheid (S presies te kwantifiseer in die Afrikaanse teks, maar ook in die Engelse en Nederlandse vertalings. Met 522 ≤ S ≤ 797 word aangedui dat Afrikaans, Engels en Nederlands al drie duidelike kleinwêreldnetwerke is. Voorstelle word ook vir verdere navorsing gemaak.

  8. Terre-Neuve ou la carte éclatée d'après le «Grand Insulaire» d'André Thevet

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    Frank LESTRINGANT

    1987-09-01

    Full Text Available Les deux cartes relatives à Terre-Neuve, représentée comme un archipel, que l'on trouve dans le Grand Insulaire inachevé du cosmographe André Thevet (circa, 1586, sont un bon témoignage des errements en partie calculés auxquels se prêtait la cartographie à l'époque des Grandes Découvertes. Pour vaincre des contraintes techniques d'une part, telles que la nécessité du montage entre des données disparates, et pour affirmer d'autre part le dessein d'une entreprise de conquête, le cosmographe — ou géographe universel — est amené à truquer, selon les règles de l'art, un document composite, prélevé à l'origine sur le planisphère de Mercator et augmenté d'informations venues des routiers portulans. Une île inédite, qui porte le nom de Thevet, a pour fonction de signer le tout.

  9. The Construction of the Other and the Self in André Gide's Travels in the Congo and Frantz Fanon's Black Skin, White Masks

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    Raphaël Lambert

    2003-06-01

    Full Text Available Reportedly, André Gide's Travels in the Congo (1929 had fostered reforms of the colonial policy in French Africa. In Travels , Gide reports cases of economic exploitation, abuses of power, use of terror, torture, and even homicidal raids against recalcitrant villagers and, at least in one case, Gide takes it upon himself to have a man prosecuted. Yet his account, through the lense of post-colonial thinking, betrays reactionary and biased views of Africans. Gide does not object to the colonial system per se , but rather blames its malfunction on both a lack of infrastructures and administrative involvement. In Black Skin, White Masks (1952, Frantz Fanon denounces colonialism, focusing on its dehumanizing effects. If Fanon believes that it is the responsibility of those oppressed to regain their freedom, he is also aware that colonized people have internalized racial stereotypes to the point of self-loathing. Hence Black Skin can be read as a rebuttal to Travels . While Travels , published only twenty years earlier, clings to values of past centuries—supporting France's "civilizing" mission in Africa, Black Skin looks toward the future as it condemns the ideology of colonialism. Both liberals, communist sympathizers and social activists, Gide and Fanon represent the two opposite poles of the colonial issue.

  10. Two new and a known species of the genus Miconchus Andrássy, 1958 (Nematoda: Anatonchidae from West Bengal, India

    Directory of Open Access Journals (Sweden)

    Jana, T.

    2008-11-01

    Full Text Available Two new and a known species of the genus Miconchus Andrássy, 1958 from the district South 24-Parganas, West Bengal, India are described and illustrated. Fifteen female and ten male representatives of Miconchus aquaticus Khan, Ahmad and Jairajpuri, 1978 were collected. Miconchus rectangularis n. sp. is characterized by medium sized body (female: 1.77-1.82 mm; buccal cavity very narrow, rectangular in shape, wall of buccal cavity straight; dorsal tooth and two sub-ventral teeth medium in size, situated at 31% from the base of buccal cavity and at same level; gonads amphidelphic; tail conoid, arcuate, gradually tapering at the end, tail-tip rounded, spinneret terminal. M. bulbicaudatus n. sp. is characterized by medium sized body (female: 2.1-2.2 mm; broad buccal cavity; dorsal tooth and two sub-ventral teeth small, situated at 31% from the base of buccal cavity and at same level; gonads amphidelphic; tail conoid, arcuate, gradually tapering at the end; tail-tip rounded with a bulbous structure encircled by caudal papillae at its base, spinneret terminal

  11. El Dioscórides de Andrés Laguna en los textos de Cervantes: de la materia medicinal al universo literario

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    Francisco López-Muñoz

    2007-12-01

    Full Text Available The literary works of Miguel de Cervantes have been widely studied from numerous points of view, including the medical one. In the present work, we defend the hypothesis that the Andrés Laguna version of Dioscorides was the source used by Cervantes in his literary passages related to therapeutic aspects, especially in relation to plants with medicinal properties. This book, a copy of which was in Cervantes’ private library, is the only medical treatise cited by the novelist in any of his writings (Don Quixote. Apart from the medicinal plants mentioned in his works, of which we have identified chicory, oleander, henbane, opium poppy, rosemary, rhubarb, tobacco, tamarisk, seeds of spurge, and vervain, Cervantes also seemed familiar with the effects of different pharmaceutical preparations produced from plants (white ointment, Aparicio’s Oil, narcotic powders, etc.. Our hypothesis is backed up by Cervantes’ use of descriptions similar to those of Laguna in his Dioscorides (the hallucinogenic effects of witches’ ointments in The Colloquy of the Dogs, the therapeutic properties of rosemary in the treatment of wounds and traumatisms in Don Quixote, the narcotic effects of opium in The Jealous Extremaduran, the psychodysleptic effects of some love potions in The Licentiate of Glass, or the toxic effects of some poisons in The Spanish-English Lady, and even, in some cases, by use of Laguna’s similar quotations (as in his reference to the purging of excessive bile in Don Quixote.

  12. La situación sociolingüística de la lengua creole de San Andrés Isla: el caso de San Luis

    Directory of Open Access Journals (Sweden)

    Deyanira Sindy Moya

    2014-09-01

    Full Text Available El presente artículo describe la situación lingüística de un sector tradicional de la Isla de San Andrés, Colombia llamado San Luis: los ámbitos de uso de las diferentes lenguas que allí coexisten; las funciones que cumplen y la relación entre lengua e identidad de los habitantes. Esta descripción surge de un estudio sociolingüístico llevado a cabo durante los años 2009 y 2010. Las conclusiones e interpretaciones de los hechos y de la información proporcionada se logran a partir de encuestas, observación participante, entrevistas e historias de vida. Los principales resultados sugieren la vitalidad de la lengua creole en los sectores tradicionales de la Isla, la expansión de ámbitos de uso del español y la posible pérdida del inglés. Como conclusiones se plantea la importancia de implementar una educación bilingüe intercultural que favorezca la protección y mantenimiento de la lengua creole y la comprensión entre pobladores y hablantes de diversas lenguas.

  13. Estructura de comunidades de peces arrecifales en cuatro atolones del Archipiélago de San Andrés y Providencia (Caribe sur occidental

    Directory of Open Access Journals (Sweden)

    Luz Stella Mejía

    2000-12-01

    Full Text Available En 1994 y 1995 se realizaron 131 censos visuales, utilizando el método de muestreo estacionario en Albuquerque Cays, Courtown Cays, Banco Roncador y Banco Serrana, atolones del Archipiélago de San Andrés y Providencia en el Caribe suroccidental. Se determinó la composición y abundancia íctica en cuatro zonas geomorfológicas: laguna, arrecife periférico de barlovento, terraza de barlovento y terraza de sotavento. En total se censaron 98 especies, de las cuales las más abundantes fueron Chromis cyanea (14%, Clepticus parra (14% y Stegastes partitus (10%. Las familias dominantes fueron Pomacentridae (37%, Labridae (28% y Scaridae (10%. El análisis de similaridad entre las zonas mostró que las diferencias entre éstas fueron mayores que las posibles diferencias geográficas entre los atolones, excepto para la laguna y la terraza de sotavento, las cuales no tuvieron diferencias significativas. Los resultados de la clasificación y ordenación confirmaron lo anterior, además en la ordenación los grupos de estaciones quedaron ubicados según un gradiente de profundidad y grado de exposición al oleaje, insinuando que estas dos variables físicas fueron las responsables del agrupamiento de las estaciones. Las diferencias en términos de equitatividad y riqueza de especies parecen ser debidas a las mismas variables. El análisis inverso dio como resultado que en cada grupo hubo pocas especies características, por ende las diferencias entre las zonas parecen ser más debidas a la dominancia de ciertas especies. Las categorías tróficas dominantes fueron planctófagos y herbívoros, los cuales fueron significativamente diferentes entre las zonas. En las someras (arrecife lagunar somero y con alta exposición al oleaje (arrecife periférico de barlovento predominaron los herbívoros, mientras que en las profundas (terrazas y arrecifes lagunares profundos los más abundantes fueron los planctófagos.In 1994 and 1995, 131 visual censuses of

  14. Physical, chemical, current profile, water pressure, sea surface temperature, meteorological, and other data from current meters, bottle casts, pressure gauges, meteorological sensors, current meters, and other instruments from the ANDRE NIZERY and other platforms from the TOGA Area - Atlantic as part of the Seasonal Response of the Equatorial Atlantic Experiment/Francais Ocean Et Climat Dans L'Atlantique Equatorial (SEQUAL/FOCAL) project from 1964-01-01 to 1985-12-31 (NODC Accession 8700150)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical, chemical, current profile, water pressure, sea surface temperature, meteorological, and other data were collected from the ANDRE NIZERY and other platforms...

  15. “Escribir una biografia es una experiencia investigadora fascinante”: conversaciones con la historiadora María del Mar del Pozo Andrés

    Directory of Open Access Journals (Sweden)

    Norberto Dallabrida

    2014-05-01

    Full Text Available María del Mar del Pozo Andrés cursó sus estudios universitarios en la Facultad de Filosofía y Ciencias de la Educación de la Universidad Complutense de Madrid, donde también realizó su tesis doctoral, con la cual obtuvo el Premio Extraordinario de Doctorado y una Mención Honorífica en la modalidad de Tesis doctorales en los Premios Nacionales a la Investigación Educativa 1996. Toda su actividad profesional se ha desarrollado en la Universidad de Alcalá, de la que es Catedrática de Universidad del área de Teoría e Historia de la Educación. Ha participado también en masters y actividades docentes, como profesora visitante, en las Universidades de Rotterdam, Utrecht, Hamburgo, Lisboa, Salamanca, Complutense y Autónoma de Madrid. Ha ocupado el cargo de secretaria de la Sociedad Española de Historia de la Educación y fue miembro del Comité Ejecutivo de la International Standing Conference for the History of Education (ISCHE. Como investigadora ha trabajado sobre cuestiones de la historia de la educación española, particularmente el papel de la educación en la construcción de identidades nacionales en la enseñanza primaria y el movimento de la Escuela Nueva. Es autora de diversos artículos en revistas científicas españolas y internacionales y de livros, entre los cuales “Curriculum e identidad nacional. Regeneracionismo, nacionalismos y escuela publica” (Biblioteca Nueva, 2000. En el año passado, publicó la biografia de la maestra Justa Freire, planteada desde un nivel macro-micro, sobre la cual fue echa la entrevista que sigue abajo.

  16. Valoración económica del buceo como estrategia de uso sostenible de la biodiversidad marina, Archipielago de San Andres y Providencia, Caribe Colombiano.

    Directory of Open Access Journals (Sweden)

    James Cruz. Johannie L.

    2011-11-01

    Full Text Available El buceo es un uso alternativo y no consuntivo de la biodiversidad marina que, debidamente practicado, tiene bajo impacto ambiental, estimula la conservación de los arrecifes y es una opción económica para habitantes de áreas arrecifales o con potencial para el buceo. El archipiélago de San Andrés, Providencia y Santa Catalina, declarado por UNESCO Reserva Mundial de la Biosfera Seafl ower, con 65.000 km2 de Áreas Marinas Protegidas y un extenso complejo arrecifal coralino, tiene condiciones para convertirse en un sitio de buceo de nivel mundial. Sin embargo, es poco conocido. Esta investigación analiza el potencial económico del buceo en esta región y lo compara con el de sitios muy reconocidos como Bonaire y Gran Caimán. Mediante análisis de la disponibilidad a pagar de buzos visitantes, se intenta valorar el buceo y se caracteriza el tipo de buzos que vienen al archipiélago. Se encontró disposición a pagar cifras superiores a las que se paga actualmente en otras partes del Caribe. Con un potencial estimado en $241 millones de dólares de ingresos anuales, el buceo es una interesante alternativa de desarrollo económico sostenible para estas islas que, a pesar de recibir 360.000 turistas al año, aún presentan un 66.9% de pobreza y altos niveles de desempleo.

  17. Le séjour du poète grec André Calvos à Genève et Lausanne

    Directory of Open Access Journals (Sweden)

    Michelle Bouvier-Bron

    2008-11-01

    Full Text Available L'objet de cet article était de recenser les renseignements concernant le poète grec André Calvos pendant son long séjour à Genève (mai 1821-décembre 1824 dans les Archives d'État (conditions de vie; dans les journaux genevois de l'époque (annonce de la publication de son premier recueil d'odes La Lyre, de celle des cours de littérature italienne, puis grecque qu'il se propose de donner; dans les registres de la Société de Lecture (contacts probables avec l'helléniste Élie-Ami Bétant, l'homme politique James Fazy et le comte Jean Capodistrias. Nous nous sommes interrogée sur les relations qu'il a pu avoir avec les réfugiés piémontais et lombards arrivés nombreux à Genève en 1821 et 1822, et surtout avec le célèbre révolutionnaire Filippo Buonarroti. Enfin, nous donnons une transcription diplomatique de la lettre de recommandation en faveur de Calvos que Jean Capodistrias, alors installé à Genève, adresse le 8 novembre 1824 à Lausanne à son ami Frédéric-César de La Harpe, ancien précepteur du tsar Alexandre et, à l'époque de Calvos, personnage hautement contestataire, proche de la Charbonnerie.

  18. Descripción morfoagronómica de materiales de plátano (Musa AAB, ABB y banano (Musa AAA cultivados en San Andrés Isla Morpho-agronomic Description of Plantain (Musa AAB, ABB and Banana (Musa AAA Materials Grown in San Andres Island

    Directory of Open Access Journals (Sweden)

    Oscar Javier Parra Pachón

    2009-10-01

    Full Text Available Durante el primer semestre de 2005 se estudiaron los cultivares de plátano y banano en fincas y parcelas de 15 agricultores típicos participantes en programas conjuntos de la Secretaría de Agricultura y Pesca de San Andrés Isla y de la Universidad Nacional de Colombia sede Caribe. A partir de descriptores de INIBAP, IPGRI y CIRAD y revisiones bibliográficas.se describen morfológicamente los materiales de Musa cultivados en la Isla, así como las prácticas de los productores isleños, Se identificaron cuatro clones del subgrupo plátano (Musa AAB: un Hartón (‘Horse’ y tres Dominico-Hartón (‘Tallo Negro’, ‘Tallo Blanco’ y ‘Cincuenta’ del subgrupo ABB se hallaron un material de Bluggoe (‘Boscó’ y un Felipita. El subgrupo banano AAA presentó dos materiales Gros Michel (denominados Común y Chino y uno de banano (Rojo. El plátano tiene gran importancia para los agricultores de la Isla, siendo el Boscó el clon más aceptado entre consumidores por su adaptación a las condiciones edafológicas y climáticas. El banano es menos cultivado; ya que los suelos, el clima y las enfermedades como sigatoka negra, condicionaron el desarrollo de clones. El trabajo sugiere prácticas de fácil implementación que podrían aumentar la producción en los sistemas de huerto mixto tropical que predominan en la Isla.During the first semester, 2005 we studied the plantain and banana cultivars in small farms of 15 volunteer regular producers, who were participating in joint programs of the Agriculture and Fisheries Secretariat of San Andres Island and the Colombian National University Caribbean Headquarters. We described morphologically the Musa cultivars identified in the island, as well as agricultural practices of the island producers, using the INIBAP, IPGRI and CIRAD (1996 descriptors and bibliographical reviews. We identified four clones within the plantain sub-group Musa AAB: a Horn type and three French-Horn; and within the ABB

  19. 'Sidun' e 'Creuza de mâ' di Fabrizio De André (1940–1999). La svolta etnica del cantautore genovese attraverso l’analisi di due canzoni esemplari

    OpenAIRE

    Vanna Lovato

    2014-01-01

    L’album Creuza de mâ (1984) di Fabrizio De André, composto e registrato grazie alla fondamentale collaborazione del musicista Mauro Pagani, rappresenta un unicum nella storia della canzone italiana, ed è più in generale un buon esempio di canzone d’autore moderna rielaborata secondo parametri musicali e linguistici diversi dagli standard della canzone di consumo tipici dell’epoca in cui l’album venne pubblicato, anticipando di quasi un decennio in Italia la moda della cosiddetta world music. ...

  20. Andréa Slemian. Sob o Império das Leis. Constituição e unidade nacional na formação do Brasil (1822-1834

    Directory of Open Access Journals (Sweden)

    Oscar Javier Castro

    2010-07-01

    Full Text Available El constitucionalismo moderno y la formación de los Estados nacionales son procesos que comenzaron a tomar forma con las revoluciones, a ambos lados del Atlántico, a finales del siglo xviii y a comienzos del xix. El tópico examinado por Andréa Slemian hace parte de estos procesos. Analiza cómo se comenzaron a sentar las bases del constitucionalismo moderno liberal y la formación del Estado nacional en Brasil, que, a pesar de sus particularidades, estaba conectado con los procesos revolucionarios hispanoamericano, estadounidense y europeo.

  1. Conocimiento sobre el fenómeno de las drogas en entre estudiantes y docentes de la Facultad de Medicina Universidad Mayor de San Andrés, La Paz, Bolivia

    OpenAIRE

    Navia-Bueno,Maria del Pilar; FARAH-BRAVO, Jacqueline; YAKSIC-FERAUDY, Nina; Philco-Lima, Patrícia; TAKAYANAGUI,Angela Maria Magosso

    2011-01-01

    El objetivo de este estudio fue identificar el grado de conocimiento de los estudiantes y docentes de salud sobre drogas lícitas e ilícitas, relacionadas a: tipo, clasificación, acción, mecanismos, daños, consecuencias y efectos adversos además del uso y consumo. El diseño metodológico fue de "corte transversal, con una muestra de 172 estudiantes, profesores y residentes de las áreas de medicina y enfermería de la Universidad Mayor de San Andrés (UMSA), en Bolivia. Los resultados revelan que ...

  2. Tydeid and triophtydeid mites (Acari: Tydeoidea) associated with grapevine (Vitaceae: Vitis spp.) in Brazil, with the descriptions of species of Prelorryia (André, 1980) and Tydeus Koch, 1835.

    Science.gov (United States)

    Da Silva, Guilherme Liberato; Da Cunha, Uemerson Silva; Rocha, Matheus Dos Santos; Panou, Eleni N; Ferla, Noeli Juarez

    2014-06-11

    We report on the Tydeidae and Triophtydeidae associated with grapevine (Vitis labrusca L. and Vitis vinifera L.) in Rio Grande do Sul State, Brazil, and describe a new species of Prelorryia, Prelorryia labrusca sp. nov., and two new species of Tydeus, Tydeus manoi sp. nov. and Tydeus riopardensis sp. nov. Brachytydeus formosa (Cooreman), B. podocarpa (Baker), Neolorryia pandana (Baker), Tydeus californicus (Banks), Pretydeus henriandrei Kaźmierski and Triophtydeus lebruni (André) are recorded and illustrated. A key to species of Tydeidae and Triophtydeidae from Brazil is provided. 

  3. Integración Nacional y Pluralismo cultural en la radio y la televisión de San Andrés Isla: La configuración historica del campo periodístico.

    Directory of Open Access Journals (Sweden)

    Orlando Javier Trujillo Irurita.

    2004-07-01

    Full Text Available El presente artículo recrea los principales hitos de la historia de la radio, la televisión y la conformación del campo del periodismo en San Andrés Isla (Colombia. Se elabora un recorrido por las principales emisoras radiales y canales de televisión que ha tenido la isla y se examina el papel que han jugado estos medios masivos de comunicación en la integración nacional y en la promoción de la pluralidad cultural.

  4. Uso de esteróides andrógenos anabólicos por praticantes de atividade física das principais academias de Erechim e Passo Fundo/RS

    OpenAIRE

    F. FRIZON; Macedo,S.M.D; M. YONAMINE

    2009-01-01

    Os esteróides andrógenos anabólicos (EAA) são substâncias quimicamente semelhantes à testosterona e que teriam a propriedade de aumentar a força e a massa muscular. Apesar de estarem associados a uma série de efeitos nocivos, principalmente sobre os sistemas cardiovascular, hepático e neuro-endócrino, verifica-se que o abuso de EAA tem aumentado consideravelmente nos...

  5. FUNARI, Pedro Paulo A. & ZARANKIN, Andrés. (Org. Arqueologia de La Represión y la Reistencia en América Latina 1960 – 1980. Córdoba: Encuentro Grupo Editor, 2006.

    Directory of Open Access Journals (Sweden)

    Rafael Milheira

    2012-09-01

    Full Text Available O livro Arqueologia de la Represión y laResistencia en América Latina 1960 – 1980, editado pelos arqueólogos Pedro Paulo Funari e Andrés Zarankin, retoma uma discussão importante para a história contemporânea da América, pois trata de um momento histórico que não  deve nunca ser esquecido,  mas contrariamenteaisso, sempre recordado e refletido.

  6. Muusika : Hortus Musicus Moskvas. Eesti Rahvusmeeskoor Toulouse'is. Joaquín Rodrigo 100. Georg Ots kuuel plaadil. "Kiriku laulu- ja palveraamat" ئ 10. "Vikerraadio" heategevuskontsert. Artur Kapi ühingu esimees on Andres Uibo / Vello Mäeots

    Index Scriptorium Estoniae

    Mäeots, Vello, 1940-2015

    2001-01-01

    20. XI esines Hortus Musicus Moskvas Eesti saatkonnas. Eesti Rahvusmeeskoor kandis 15.XI Toulouse'is koos Toulouse'i Rahvusliku Linnaorkestriga ette Jean Sibeliuse "Kullervo". 22.XI tähistatakse hispaania helilooja Joaquín Rodrigo 100. sünniaastapäeva. Estonia teatri Valges saalis esitleti kogumik-CD-d "Georg Ots ئ Anthology". "Kiriku laulu- ja palveraamat" sai 30.XI 10. aastaseks. 3.XII toimub Tallinnas Kaarli kirikus "Vikerraadio" heategevuskontsert "Aita alustada elu". 26.X asutati Suure-Jaanis Rahvusvaheline Artur Kapi Ühing, mille esimeheks valiti organist Andres Uibo

  7. Avaliação de política ambiental e sustentabilidade: estudo de caso do município de Santo André - SP Environmental policy assessment and sustainability: case study of Santo André City - SP - Brazil

    Directory of Open Access Journals (Sweden)

    Juliana Pellegrini Cezare

    2007-12-01

    Full Text Available A gestão da Região Metropolitana de São Paulo tem como um dos desafios resolver a problemática do uso e ocupação do solo em áreas de proteção de mananciais, visando proteção dos recursos hídricos desta região. Este artigo tem como objetivo contribuir para a discussão sobre Avaliação de Estratégia de Desenvolvimento Sustentável, a partir de uma análise das políticas ambientais do Município de Santo André, no contexto da proteção dos recursos hídricos. Propõe-se a verificar, com base nos Princípios de Bellagio, se houve enfoque sistêmico, transparência, participação e engajamento social no processo de formulação e implementação de suas políticas ambientais. Observou-se coerência nas políticas, programas e ações estudadas, entretanto, foram identificadas lacunas que, sobre o enfoque estratégico, representam fraquezas na construção da sustentabilidade local, como no caso da ausência de um sistema consolidado de indicadores de sustentabilidade.The management of the São Paulo Metropolitan Area has as one of the challenges to bring a sustainable solution for land use in watershed protection areas, aiming at regional water resources protection. This paper has the objective to contribute to the discussion about Sustainable Development Strategy Assessment, from an analisys with focus at the environmental policies of the Santo André City - SP Brazil, in the context of water resources protection. For this, the proposal is to verify, based on the Bellagio Principles, the use of systemic approach, transparency, participatory process and social engagement in its policy formulation and implementation process. It was observed coherence within the policies, programmes and actions analysed, nevertheless, gaps were identified, which, within a strategic approach, means weakness for the construction of the local sustainability, as the lack of a consolidated sustainability indicators system.

  8. Juventude, intelectualidade e política: a ativação do "legado" de André Forster e a consagração de uma geração Youth, intellectuals and politics: the activation of André Foster's "legacy" and the acclamation of a generation

    Directory of Open Access Journals (Sweden)

    Eliana dos Reis

    2003-01-01

    Full Text Available Este artigo trata da temática referente às dinâmicas de construções geracionais e ao trabalho de memória, ativados por determinados agentes sobre um momento histórico específico. Para tanto, propõe-se, num primeiro momento, uma breve discussão bibliográfica sobre as noções de «geração» e «memória», principalmente sobre o potencial heurístico destas. No momento seguinte, o empreendimento recai na análise de um conjunto de narrativas e homenagens centradas na mobilização política da juventude de esquerda do MDB gaúcho na «luta contra a ditadura» (especialmente o exame de um Grande Expediente realizado na Assembléia Legislativa do RS em homenagem póstuma ao sociólogo e líder político André C. Forster. Com estes dois momentos pretende-se discutir o uso operacional de determinadas categorias para a compreensão dos movimentos históricos e dos personagens que os animam.This article deals with the themes related to the construction of generational dynamics and the memory work activated by certain agents on a specific historical moment. In order to do that, a brief bibliographical discussion is firstly proposed on the notions of "generation" and "memory", specially on their heuristic potential. Afterwards, an analysis is developed of a group of narratives and tributes centered on the leftist youth's mobilization within Rio Grande de Sul's MDB (Brazilian Democratic Movement in the "struggle against the dictatorship" (specially the examination of state parliament special session as a posthumous tribute to sociologist and political leader André C. Forster. Based on thos e two moments we intend to discuss the operational use of some categories to understand historical moments and the characters that animate them.

  9. Microbial Inoculantes Effects on Growth Promotion of Mangrove and Citrullus vulgaris San Andrés Isla, Colombia Efecto de los inoculantes microbianos sobre la promoción de crecimiento de plantulas de mangle y plantas de Citrullus vulgaris San Andrés Isla, Colombia

    Directory of Open Access Journals (Sweden)

    Galindo Tania

    2006-06-01

    Full Text Available In order to test the effect of two microbial inoculants (obtained from red and black mangrove roots on the growth and stability of mangrove and watermelon plants, four treatments were carried out in San Andres Island, Colombia. The treatments consisted in the application of the inoculants in: A. germinans propagules collected in a mangrove area, and then individually planted in gavels with sun-pasteurized soil (in order to decrease the microbial load, A. germinans and R. mangle plants collected in the proximity of nursery trees, A. germinans and R. mangle planted and maintained in nursery, and in Citrullus vulgaris seeds planted in a traditional cultivar without chemical fertilizers. The growth and vegetative development variables were: number of nodes, number of leaves and steam length. The inoculants (phosphate solubilizing microorganisms -PSM- and nitrogen fixing bacteria -NFB- were applied in the mentioned vegetable material, doing measures during three months. The results show a positive effect on growth measured by steam length in plants treated specifically with the inoculants in C. vulgaris and A. germinans seedlings maintained in nursery.Con el fin de probar la efectividad de dos inoculantes microbianos (aislados a partir de raicillas de mangle rojo y negro en el crecimiento y establecimiento de plántulas de mangle y de patilla, se realizaron cuatro pruebas en campo en San Andrés Isla, Colombia. Se aplicaron dichos inoculantes en: propágulos de Avicennia germinans colectados en un área de manglar y sembrados en macetas sobre sustrato solarizado (con el fin de disminuir la carga microbiana, plántulas de A. germinans y Rhizophora mangle colectadas en cercanía de árboles semilleros, plántulas de A. germinans y R. mangle sembradas y mantenidas en vivero y en semillas de patilla (Citrullus vulgaris sembradas en un cultivo libre de fertilizantes químicos. Las variables tomadas como indicativo de crecimiento y desarrollo vegetal

  10. Gestão dos serviços de água e esgoto nos municípios de Campinas, Santo André, São José dos Campos e Santos, no período de 1996 a 2000 The management of water and sewage services in Campinas, Santo André, São José dos Campos and Santos, from 1996 to 2000

    Directory of Open Access Journals (Sweden)

    Rita de Cássia Ogera

    2005-03-01

    Full Text Available Este trabalho tem como objetivo analisar a gestão dos serviços de água e esgoto nos Municípios de Campinas, Santo André, São José dos Campos e Santos, no período 1996 - 2000. Nos Municípios de Campinas e Santo André, a gestão desses serviços encontra-se na esfera de governo municipal, enquanto nos Municípios de São José dos Campos e Santos, a gestão encontra-se na esfera de governo estadual. Os métodos adotados foram pesquisa bibliográfica, pesquisa documental, pesquisa descritiva e investigação explicativa fundamentada pela teoria, seguida de análise dos resultados. Políticas públicas e políticas de governo foram tomadas como parâmetros para analisar as diferenças na eficiência e na eficácia da gestão desses serviços. Como resultados foram apontadas características e diferenças na eficiência e na eficácia da gestão dos serviços de água e esgoto nos âmbitos municipal e estadual.This study intends to analyze the water and sewage services management in Campinas, Santo André, São José dos Campos and Santos, from 1996 to 2000. In Campinas and Santo André, the municipal government implements the management of these services. In São José dos Campos and Santos, it is a State-level operation. The methods used for this paper were bibliographic, descriptive, and documental researches, and a subsequent theoretical explanation followed by an analysis of the results. Public and government policies were used as parameters to analyze differences in efficiency and efficacy of those services managements. The results obtained show characteristics and differences between State-level and municipal-level managements of the water and sewage treatments.

  11. Gestión ambiental para los subproductos derivados de una planta de tratamiento de aguas en el Jardín Botánico de la Universidad Nacional de Colombia y comparación con sistemas similares en San Andrés Isla / Environmental management for by products derived from a plan of wastewater treatment in the botanical gardens of the national university of Colombia and comparison with similar systems in San Andres Island

    OpenAIRE

    Rodríguez Cotua, Eder Andrés

    2008-01-01

    Las plantas de tratamiento de aguas residuales (PTAR) han sido diseñados para el control de la contaminación de las aguas residuales domésticas e industriales. El jardín Botánico de la Universidad Nacional de Colombia ubicado en la isla de San Andrés (Caribe Colombiano), esta instalando una PTAR de lodos activados la cual producirá lodos biológicos y aguas tratadas. Como parte de la asignatura trabajo de grado se realizó una pasantia con el fin de gestionar ambientalmente los subproductos de ...

  12. Energy world governance. Review of the conference which was held at IFRI, 26 March 2009, with Tatsuo Masuda, Andre Mernier et Richard H. Jones; La gouvernance mondiale de l'Energie - Resume de la conference qui a eu lieu a l'Ifri le 26 Mar 2009 autour de Tatsuo Masuda, Andre Mernier et Richard H. Jones

    Energy Technology Data Exchange (ETDEWEB)

    Schulke, Ch.

    2009-07-01

    The conference was related with some of the major questions concerning global energy governance today, the role of the different international organizations dealing with energy, the rules of the game between market and state players, the efforts to deal with climate change, and the integration of emerging countries in global energy governance, the roles of the different international organizations dealing with energy (will we see further fragmentation or more cooperation between them?). Tatsuo Masuda in his contribution discussed global energy governance from an oil perspective. Andre Mernier noted the particular nature of the Energy Charter, which, as it is founded upon an international treaty, is unlike other organizations in being legally binding. The legal basis of the organization means that agreements are especially powerful. Then Richard H. Jones underlined that last summer's volatility in oil markets, the ensuing financial and economic crisis, the major disruption in gas supplies to European markets this winter and the upcoming climate change negotiations have led to increasing calls for a stronger global dialogue on energy issues. This dialogue should deal with prices and investment, energy security and climate change

  13. Fatores de risco para uso do tabaco em adolescentes de duas escolas do município de Santo André, São Paulo Risk factors for tobacco use in adolescent students of two high schools of Santo André city, São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Halley Ferraro Oliveira

    2010-06-01

    Full Text Available OBJETIVO: Avaliar fatores de risco para uso de tabaco em estudantes de duas escolas do ensino médio do município de Santo André (SP em 2005, bem como traçar o perfil do adolescente experimentador do fumo. MÉTODOS: Estudo transversal, com questionário padronizado, autoaplicável e anônimo aplicado a adolescentes escolares de ambos os sexos, matriculados no primeiro ano do ensino médio de duas escolas de Santo André, uma particular e outra pública. Foram levantadas as seguintes variáveis: idade, sexo, raça, prática de esportes, religião e hábitos do adolescente e da família. Definiu-se como "experimentador do fumo" o adolescente que experimentou cigarro (tabaco e não continuou o hábito tabagista. Foi feita a análise descritiva com o teste do qui-quadrado e os fatores de risco para "experimentar fumo" foram analisados por regressão logística. RESULTADOS: Dos 232 questionários aplicados, 226 (90% foram respondidos, sendo 137 (61% na escola particular e 89 (39% na estadual. Dentre os entrevistados, 54 (24% referiram já ter experimentado tabaco uma vez na vida (35 na escola privada e 19 na pública. Foram fatores de risco significativos para experimentar fumo na escola particular: mãe fumante (OR 12,4; IC95% 4,1-37,8 e amigos fumantes (OR 9,6; IC95% 3,1-29,9. Na escola pública, os fatores de risco para a mesma variável foram: consumo de bebida alcoólica (OR 8,8; IC95% 1,9-40,1, amigos fumantes, (OR 7,9; IC95% 1,9-31,3 e contato com fumaça do cigarro (OR 6,4; IC95% 1,6-26,2. CONCLUSÕES: Observou-se influência significativa do meio ambiente do adolescente, inclusive social e familiar, para a experimentação do tabaco.OBJECTIVE: To evaluate risk factors for tobacco use in high school students of two schools of the city of Santo Andre (São Paulo, Brazil in 2005, as well as to describe the profile of the adolescent who uses tobacco. METHODS: Cross sectional study that applied a standardized anonimous self

  14. Análisis del modelo turístico de la isla de San Andrés, reserva de biosfera seaflower, Caribe colombiano. Una exploración del estado actual.

    Directory of Open Access Journals (Sweden)

    Paula Andrea Zuluaga Cadavid

    2006-11-01

    Full Text Available Este trabajo analiza el modelo turístico de la isla de San Andrés y su correspondencia con una visión que busca el desarrollo de la actividad en un área de manejo especial, se realiza una revisión de los planes actuales de desarrollo territorial y turístico para el destino. Se estudia cómo estos ponderan la calidad territorial y ambiental. Estos factores son fundamentales en la competitividad turística del destino, en respuesta a su declaración como Reserva de Biosfera Seaflower por la unesco. Ésta le confiere una política de compromiso mundial en defensa del paisaje, los ecosistemas y las especies, promoviendo un desarrollo sostenible. Con este enfoque se evidencian las dificultades en la articulación del modelo propuesto con las estrategias formuladas para la gestión. Éstas van a incidir directamente en la depreciación de sus recursos turísticos. Se podría especular que el caso de San Andrés refleja lo que acontece en un Caribe desigual y fragmentado.

  15. La Biblioteca Max von Buch de la Universidad de San Andrés y sus investigadores: Segunda parte de Un estudio de las necesidades de información, hábitos y características de Investigadores en Humanidades y Ciencias Sociales The Max von Buch library of the Universidad de San Andres and its researchers: Second part of A study of the information needs, habits and characteristics of Humanities and Social Science Researchers

    Directory of Open Access Journals (Sweden)

    Irene Münster

    2003-12-01

    Full Text Available Tal como fue mencionado en el artículo anterior el presente estudio fue elaborado con el propósito de entender e identificar las necesidades, el proceso de búsqueda de información, las características y los hábitos de los investigadores en Humanidades y Ciencias Sociales de la Universidad de San Andrés (UdeSA. En esta segunda parte del mismo se ha intentado identificar y evaluar su conducta en la Biblioteca Max von Buch de la Universidad a través del uso de los servicios que ésta les ofrece. Se ponen a consideración los resultados de una encuesta realizada, de la que se adjunta la segunda parte del formulario, con el fin de detectar sus necesidades de información.As mentioned in the previous article, the present study was conducted to understand and identify the characteristics, needs and habits of research from the Humanities and Social Sciences researchers at the Universidad de San Andres (UdeSA. This second part tries to identify and evaluate their performance at the Max von Buch library of the University through the services that it provides them. The results of the survey are presented, together with the second part of the questionnaire, with the aim of identifying information needs.

  16. Two members of the CERN HPD team present their babies. André Braem (left) holds in his hands a 5-inch glass HPD, while a ceramic HPD for medical applications is shown by Christian Joram. The large detector in the middle is a 10-inch HPD developed for an astrophysics experiment.

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Two members of the CERN HPD team present their babies. André Braem (left) holds in his hands a 5-inch glass HPD, while a ceramic HPD for medical applications is shown by Christian Joram. The large detector in the middle is a 10-inch HPD developed for an astrophysics experiment.

  17. Surmahiirte tants; Pühapäeva hommik; Unistus venna külaskäigust; Kolm päeva voodipuhkust; Veepiir; Ei sugutunnuseid ega muid iseärasusi : [Luuletused] / Wallace Stevens ; inglise k. tlk. ja järelsõna: Andres Ehin

    Index Scriptorium Estoniae

    Stevens, Wallace

    1996-01-01

    Autorist lk. 212. Luuletuste 'Unistus venna külaskäigust', 'Kolm päeva voodipuhkust', 'Veepiir' ja 'Ei sugutunnuseid ega muid iseärasusi', mis on samuti ekslikult sealsamas W. Stevensile omistatud, autor on tegelikult Carlos Stewal. Vt. Ehin, Andres. Veavabandus // Looming. 1995. Nr. 5. Lk. 718

  18. O Ateísmo Francês Contemporâneo: uma comparação crítica entre Michel Onfray e André Compte-Sponville (Contemporary French Atheism: a Critical Comparison between Michel Onfray and André Comte-Sponville - DOI: 10.5752/P.2175-5841.2010v8n18p127

    Directory of Open Access Journals (Sweden)

    Agnaldo Cuoco Portugal

    2011-04-01

    Full Text Available Michel Onfray e André Comte-Sponville são os dois mais famosos representantes do ateísmo filosófico francês contemporâneo, que continua uma tradição iniciada no século XVIII de negação irreligiosa da noção monoteísta de Deus. Embora compartilhando várias ideias, como o naturalismo e, obviamente, a rejeição do monoteísmo, suas propostas têm diferenças importantes. Onfray imputa à religião a maioria dos males enfrentados pela humanidade, recusando-se a fazer qualquer concessão à tradição religiosa monoteísta, e propondo uma filosofia libertária de tipo hedonista e materialista. Comte-Sponville vê aspectos positivos na religião no tocante à manutenção da unidade social e propõe uma espiritualidade mística ateia. O artigo faz uma breve apresentação de suas teses e formula críticas a ambas as propostas. Onfray está muito mais preocupado em convencer de uma proposta política do que em argumentar filosoficamente em favor de uma tese e Comte-Sponville não parece perceber as consequências auto-refutadoras do naturalismo, que também torna muito problemática a própria noção de moralidade. Palavras-chave: Michel Onfray; Comte-Sponville; ateísmo; neoateísmo; naturalismo.  Abstract Michel Onfray and André Comte-Sponville are the most famous representatives of philosophical contemporary French atheism, which is a continuation of a tradition begun in the 18th Century of irreligious denying of the monotheistic notion of God. Although sharing many ideas, like naturalism and, obviously, the rejection of the monotheistic conception of God, their proposals show important distinctions. Onfray blames on religion most of evils faced by humanity, refusing to make any concession to monotheism, and proposing a libertarian, hedonistic, materialistic philosophy. Comte-Sponville sees positive aspects in religion regarding the keeping of social unity, and puts forward an atheistic spirituality. The article makes a brief

  19. André P. Brink

    African Journals Online (AJOL)

    Owner

    Anything that the National Party could dream of doing, the ANC can and will do ten times ... Ultimately, Brink always had a prophetic vision of and on the tension between state and author/artist, between raw power and those that defied it creatively by.

  20. Avastades muinasjuttude muinasjutte / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2005-01-01

    Mängufilm Peeter Paani kuju loojast kirjanik James M. Barrie'st "Avastades Eikunagimaad" ("Finding Neverland") : režissöör Marc Forster : peaosas Johnny Depp : Ameerika Ühendriigid - Suurbritannia 2004

  1. André P. Brink

    African Journals Online (AJOL)

    Tom

    met die Martin Luther King Memorial Prize (1980). Vanweë sy noue verbintenis met die Franse kultuurlewe is hy op verskillende wyses deur die Franse vereer. In 1980 word die Prix Médicis Étranger, die hoogste Franse toekenning vir internasionale literatuur, aan hom toe- geken. Hierdie eerbewys word opgevolg toe hy tot ...

  2. Kirjad Viljale Bakuus / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2008-01-01

    Kirjavahetus Bakuus elava ja töötava Vilja Peetsi ning Tallinnas elava Vidadi Mamedoviga Aserbaidžaani kultuuriloo, poliitika, ajaloo ja ühiskonnaelu teemadel. Puudutatakse ka Montesquieu Pärsia kirju, Voltaire'i Filosoofilisi jutustusi ja Ahhundovi Kämalüddövlä kirju

  3. Vedaja vabanemine vastutusest / Andres Põder

    Index Scriptorium Estoniae

    Põder, Andres

    2017-01-01

    Vedaja vastutusest vabanemise alustest rahvusvahelise kaupade autoveolepingu konventsiooni (CMR) artikkel 17 lõike 2 alusel. Vedaja vabanemisest vastutusest vääramatu jõu ja vältimatute asjaolude korral. Sisaldab asjakohast kohtupraktikat

  4. DVD-d / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Kolm mängufilmide DVD-d : ameerika sõltumatu mängufilm "Karm tüdruk" ("Hard Candy"; režissöör David Slade; 2005), ameerika mängufilm "Kaitseingel" ("The Guardian"; režissöör Andrew Davis; 2006) ja Venemaa õudusfilm "Surnud tütred" ("Mjortvõje dotsheri"; režissöör Pavel Ruminov)

  5. DVD-d / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Lühitutvustused DVD-del ilmunud filmide kohta - "Jan Uuspõld läheb Tartusse" (A. Maimik, R. Tolk, Eesti 2007), "Öö muuseumis" ("Night at the Museum"; Shawn Levy, USA 2006), "78. paragrahv. 2." (Mihhail Hleborodov, Venemaa)

  6. Kaljujooniste keskus Arizonas / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    1998-01-01

    Arhitekt William Bruderi projekteeritud kaljujooniste uurimis- ja eksponeerimiskeskus Phoenixis, Arizonas säilitab kivijooniseid, mille autoriteks olid sealset piirkonda kuni 16. sajandini asustanud hohokamid

  7. Puitarhitektuuri preemiad - 2009 / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2009-01-01

    Konkursist "Eesti Parim Puitehitis 2009" ja premeeritud töödest. Peapreemia pälvis suvila (EasyHome'i moodulmaja) Jõelähtmel, arhitekt Sten Ader (SKAD Arhitektid). Eripreemiate saajad, äramärgitud töö

  8. Saaremaa politseijuht pensionile / Andres Sepp

    Index Scriptorium Estoniae

    Sepp, Andres, 1976-

    2005-01-01

    Kuressaare politseijaoskonna ülemkomissar Ants Ley esitas politseiametile lahkumisavalduse. Väidetavalt on nimetatud ühe võimaliku politseijuhikandidaadina Lääne prefektuuri teenistusosakonna komissari Aare Alliku nime. Lisa: Ants Ley

  9. Baroki pidulik vaim / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    1999-01-01

    Hispaania väikelinna Murcia uus linnavalitsuse hoone. Kohaliku liivakiviga kaetud tagasihoidlikku hoonet iseloomustavad fasaadipostide rahutu rütm ja nende vahel läbi kahe korruse kõrguv aken. Arhitekt Rafael Moneo.

  10. Mõistulood ungari moodi / Andres Allpere

    Index Scriptorium Estoniae

    Allpere, Andres

    2000-01-01

    Ungari mängufilmidest : "Mulle andis Vanajumal Pestis laterna kätte" ("Nekem lámpást adott kezembe az Úr Pesten"), režisöör Miklós Jancsó; "Nägija Simon" ("Simon mágus"), režisöör Ildikó Enyedi; "Süüdistus" ("A vád"), režisöör Sándor Sára ja "6 : 3", režisöör Péter Tímár

  11. Elagu noor kino! / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    2007-01-01

    Käesoleva TMK numbriga kaasas olevast DVDst "Valik eesti tudengifilme", mis tutvustab tudengite lühifilme (ilmus Kinobussi eestvõttel) : T. Toom "Tuul", B. Demidova "Roosa kleit ja nahksed püksid", K. Sarv "2pic", R. Merivoo "Mis värvi on armastus", R. Mandri "Annaliisa", E. Vasli "Nagu ikka", M. Oja "Rain Terrain" ("Varjude maa"), J. Matjus "Suvine dokumentaal", L. Kuusk, R. Võsa, M. Monko, H. Melesk "Eestimaa. Revisited", Johnson ja Johnson (I. Köster ja T. Talve) "Mõrv striptiisi ajal"

  12. Avignoni totaalne teatrifestival / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Avignoni teatrifestivalil nähtust. Lähemalt Marc Wolters'i ühemeheteater "Colt Warmers", Chapelle Sainte Claire (Alfred Jarry) "Kuningas Ubu", Herman Hesse "Sidharta" mängituna India teatritrupi poolt, "Movin' Melvin Brown : Me, Ray Charles and Sammy D. Jr" ning Virgine Mirabeau koreograafial tantsuetendus "Shoult I Stay Or..." Art's Fusion esituses

  13. Uus ports preemiaid / Andres Ehin

    Index Scriptorium Estoniae

    Ehin, Andres, 1940-2011

    2002-01-01

    Kultuurkapitali kirjanduse aastapreemiad. Proosa : Mehis Heinsaar. Härra Pauli kroonikad; Luule : Hasso Krull. Kornukoopia : sada luuletust; Näitekirjandus : Jaan Kruusvall. Hullumeelne professor, tema elukäik; Laste- ja noorsookirjandus : Aino Pervik. Paula-sari; Esseistika : Jaan Puhvel. Ulgvel ja umbes; Tõlge võõrkeelest eesti keelde : Udo Uibo. Anthoy Burgessi "Kellavärgiga apelsin"; Tõlge eesti keelest võõrkeelde : Guntars Godinsh. Jaan Kaplinski "Tolmust ja värvidest"; Artiklipreemia : Toomas Haug. Tallinna tänava kolmnurgas: peatükk kanoniseerimata kirjanduslugu; Venekeelsete autorite kirjandusauhind : Larissa Vanejeva proosaraamat "Liki".

  14. Tõsielu puhastab teatrilava / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2000-01-01

    Tallinna Linnateatri Põrgulaval esietendus 20. dets. Max Bitter jun. pseudonüümi all esineva vene näitekirjaniku Igor Shpritsi komöödia "Põhhjas", mis on paroodia Maksim Gorki näidendist "Põhjas"

  15. Vabadus teeb rikkaks / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2005-01-01

    Autor analüüsib Eesti majandusvabadust kahe edetabelipõhjal: ühte koostab alates 1996. aastast Kanadas asuv Frazeri Instituut, teist USA-s asuv Heritage Foundation ja majandusajakiri The Wall Street Journal. Diagramm: Majandusvabaduse indeksi muutus mullu Euroopa Liidus

  16. Vanglarahvas tantsib Euroopasse / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2005-01-01

    Rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre : stsenaristid Rene Vilbre, Teet Kask, Helena Jonsdottir : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir : osatäitjad Mait Malmsten, Ruslan Stepanov. Filmi võtted toimusid Tartu vanglas

  17. Crimson kirjutab ajalugu / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2002-01-01

    Crimsoni (Hollandi kunstiajaloolaste firma) raamatust "Mart Stami püksid. Lugusid Hollandi moraalse modernismi kulisside tagant", selle põhjal Piet Mondriani maali "Victory Boogie Woogie" jõudmisest 1998. a. Haagi linnamuuseumi, arhitekt Jacobus Johannes Oudi (1890-1963) imago kujundamisest ja tema loomingu rekonstrueerimisest

  18. Ja teevad filme / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    1999-01-01

    Eesti Joonisfilmi uued tööd esilinastusid 13.mail : "Viola" : režissöör Priit Tender, "Armastuse võimalikkusest" : režissöör, stsenarist ja operaator Janno Põldma, "Lotte" : režissöörid Heiki Ernits, Janno Põldma ja Priit Pärn ja reklaamfilm "Remix" : režissöör Priit Pärn

  19. Sein on ees / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    2009-01-01

    Laurent Cantet ja Françoise Begaudeau filmist "Seinte vahel", mis on pooldokumentaalne lugu probleemsest klassikollektiivist Prantsusmaa ühes riigikoolis. Filmi aluseks on kooliõpetaja Françoise Begaudeau romaan

  20. Teema endiselt õhus / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    Saksa poliitiline põnevusfilm "Balti torm" ("Baltic Storm"), mis kujutab parvlaev "Estonia" hukku : stsenarist, produtsent Jutta Rabe : režissöör Reuben Leder. Filmi Tallinna esilinastusel viibinud ajalehe Washington Times Balti korrespondendi Drew Wilsoni ja filmi stsenaristi ja kaasprodutsendi Kaj Holmbergi ütlusi teema kohta

  1. Keskerakonna menu langeb / Andres Ammas

    Index Scriptorium Estoniae

    Ammas, Andres, 1962-

    2002-01-01

    Ilmunud ka: Hiiu Leht, Koit, Vooremaa, Lääne Elu, Nädaline, Põhjarannik, Severnoje Poberezhje 10. sept. lk. 2;6;2;4;4;2;2, Sakala 11. september lk. 2, Meie Maa 11. september lk. 2, Virumaa Teataja 12. september lk. 7, Harju Uudised 18. september lk. 2. Keskerakonna tasakaalustamiseks vajab Eesti demokraatlike erakondade ühtehoidmist, vajadusel ka liitumist, leiab autor. Autor: Isamaaliit

  2. Ruum, ca 1986 / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2006-01-01

    Alates 1990. aastate algusest kuulub ruum postmodernse kultuuriteooria käibesõnavarasse, räägitakse ka "ruumilisest pöördest" kultuuriteoorias. Erinevatest ruumiloogikatest, modernse kultuuri ja ruumi klassilisest ja soolisest problemaatikast. Henry Lefebvre'i, Frederic Jamesoni, Edward Soja, Rosalyn Deutsche, Griselda Pollock'i ruumianalüüsist

  3. Forrest Gump euroliidus / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2005-01-01

    Majandusõppejõus tekitab hämmastust, et suveräänse Eesti riigi majandusministeerium kavatseb Euroopa Liidult küsida luba Leedu masuudi sisseostmiseks. Autoris tekitab see küsimuse, kas majandusruum kuhu Eesti kuulub, on ikka konkurentsile üles ehitatud

  4. Avaliku ruumi otsingul / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2005-01-01

    Liina Siibi ja Mare Pedaniku kureeritud linnakultuuri ürituste sari "Trichtlinnburg" Tallinnas 5.-15. V. Katrin Essensoni ja Helen Becki performance'itest Raekoja platsil, Viru Keskuses näidatud Sanja Ivekovici juhtimisel loodud videotööst "(If) I lived here" (s.h. Laineli Parresti klipp), Siiri Vallneri, Heidi Urbi ja Indrek Peili juhitud jalutuskäigust "Tallinna talje" jm.

  5. Filmikunsti kolm palet / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    1999-01-01

    Tallinna filmifestival linastunud mängufilmid "Reekviem" : režissöör Alain Tanner : Šveits - Prantsusmaa - Portugal 1998, "Õnnelikult koos" : režissöör Wong Kar-Wai : Hongkong 1997 ja "Tuntud vana laul" : režissöör Alain Resnais : Prantsusmaa - Šveits - Suurbritannia 1997

  6. Aasta pressifoto 2015 / Andres Haabu

    Index Scriptorium Estoniae

    Haabu, Andres

    2016-01-01

    Eesti Pressifotograafide Liidu korraldatud "Aasta Pressifoto 2015" konkursist. Peapreemia ja parim uudisfoto Andras Kralla "Okasroosipõõsas"; parim olemusfoto Liis Treimanni "Pool sajandit surmaga silmitsi"; parim spordifoto Jaanus Ree "Pool teed veel minna"; parim portreefoto Sander Ilvesti fotoseeria "Kõik oli uus aprillikuus"

  7. LA CRITIQUE IRONIQUE DE L’ACQUISITION DE LA DOCTRINE DE LIBERTE ABSOLUE DANS “L’IMMORALISTE” D’ANDRE GIDE / ANDRE GIDE’İN AHLAKSIZ ADLI ROMANINDA MUTLAK ÖZGÜRLÜK DOKTRİNİN EDİNİMİNDE İRONİK ELEŞTİRİ

    Directory of Open Access Journals (Sweden)

    Fuat BOYACIOĞLU

    2016-06-01

    Full Text Available Dans cinq romans  de Gide Les Cahiers d'André Walter, L'Immoraliste, La Porte étroite, Isabelle, La Symhonie Pastorale  on voit un protagoniste qui essaie de créer d'abord une doctrine absolue et immuable pour lui-même, puis d’ironiser son monde romanesque tout en faisant contact avec le monde extérieur et la vie réelle et  de juger et critiquer ses anciens sentiments. Une évolution psychologique à trois étages est vue chez le protagoniste. Dans son Immoraliste Gide nous montre l'évolution à trois étapes de son héros Michel qui, libéré de la conception morale protestante, oppose au  moralisme traditionnel et tente d'obtenir une liberté absolue. Dans la première étape, le héros constitue une conception de la liberté absolue incompatible avec la vie réelle sous la influence de Ménalque, un philosophe immoraliste dont la philosophie consiste en immoralisme et hédonisme. Dans la deuxième étape, Michel lutte pour obtenir une liberté absolue et cherche à pratiquer sa doctrine: Michel est attiré par les personnes vivant dans la pauvreté dépourvue de la sagesse de la vie. Il néglige sa femme qui tombe malade. Il vit les allées et les venues entre le bien et le mal. Il préfère le mal. Il cause la mort de sa femme. Il devient prisonnier de ses passions et ses désirs pédophiles. Dans la troisième étape, Michel fait face à la réalité de la vie. Il est déprimé et ne sait pas comment sortir de cette vie infernale. Il découvre que la doctrine de la liberté absolue lui mène à la misère et à la déception et ne fait pas le bonheur. Le fait qu'il se repent de ses pervers des relations sexuelles et qu’il invoque à ses amis nous montrent l'ironie de la doctrine de la liberté absolue. Gide’in, André Walter’in Defterleri (Les Cahiers d’André Walter, Ahlaksız (L’Immoraliste, Dar Kapı (La Porte étroite, Isabelle, Kır Senfonisi (La Symhonie pastorale adlı beş anlatı(récit diye nitelendirdi

  8. Andres Lipstok : 2008. aasta kustutab Eestist odava allhanke ettevõtted / Andres Lipstok ; interv. Andres Reimer

    Index Scriptorium Estoniae

    Lipstok, Andres, 1957-

    2008-01-01

    Ilmunud ka: Vesti Dnja 21. jaan. lk. 5. Eesti Panga presidendi sõnul jõuab praeguse prognoosi kohaselt majandus kasvukiiruse madalseisu esimesel poolaastal, mõni ettevõte, mis kasutab näiteks odavat tööjõudu, võib minna pankrotti. Prognoosi põhjal ei tohiks Eesti majandus tänavu nulli langeda. Selgitus, miks Eesti peaks ikkagi eurole üle minema ja seda võimalikult kiiresti

  9. Obras tempranas de vivienda por André Wogenscky (1956-1970: la relación entre el cuerpo, la atmósfera interior y la envolvente

    Directory of Open Access Journals (Sweden)

    Ignasio Requena-Ruiz

    2014-12-01

    Full Text Available Durante veinte años André Wogenscky fue uno de los más fieles colaboradores de Le Corbusier. El presente artículo discute cómo sus primeros trabajos (1956-70 suponen una evolución de las lecciones del maestro a través de una comprensión sensorial de la relación entre cuerpo humano, arquitectura y clima. En particular, se aborda su acercamiento a las cuestiones ambientales y la percepción humana en sus proyectos de vivienda. Este trabajo está basado en una investigación original en los archivos Wogenscky del Centre d’archives d’architecture du XXe siècle en el Institute français d’architecture.

  10. Saint-André-des-Eaux (Côtes-d’Armor : nouveaux éléments sur l’église et sur ses décors peints

    Directory of Open Access Journals (Sweden)

    Mathias Dupuis

    2009-09-01

    Full Text Available Nous avions déjà présenté dans le précédent numéro du Bulletin du Centre d'études médiévales d’Auxerre les premières recherches sur l’ancienne église paroissiale de Saint-André-des-Eaux . La réalisation de sondages en juin 2008 ainsi qu’une dernière série d’observations sur le bâti, préalables à la consolidation des murs de l’église et des vestiges de peintures murales, permettent désormais de mieux cerner l’histoire monumentale de cet édifice et de ses décors peints.Quatre sondages ont été o...

  11. Prevenção de anemia no primeiro ano de vida em centros de saúde do município de Santo André, São Paulo

    DEFF Research Database (Denmark)

    Szarfarc, S C; Berg, Gabriele; Santos, A L

    1996-01-01

    The aim of this study was to evaluate the efficacy of an iron prophylactic supplementation program, in three health centers of Santo André, in São Paulo state. The prevalence of anemia was identified in a control group consisting of 201 children of 1 year old. The intervention group consisted...... and anemia and its risk to children's health. When the children were 12 months old, the diagnosis of anemia was made through dosage of hemoglobin concentration and the results were compared with those of the control group. It was verified that the 2 groups presented similar prevalences. It is important...... to realize that children with low frequency of visits to the health centers had prevalence of anemia significantly higher than those with high frequency. Some factors that possibly contributed to the result of the intervention are discussed....

  12. El General en su laberinto de Gabriel García Márquez y Conviene a los felices permanecer en casa de Andrés Hoyos: dos visiones de la Independencia de Colombia

    Directory of Open Access Journals (Sweden)

    Gustavo Forero Quintero

    2011-07-01

    Full Text Available The aim of this essay is to compare the political perspectives put forward by two historical novels tackling the theme of Colombia’s Independence: El General en su laberinto (GL by Gabriel García Márquez, and Conviene a los felices permanecer en casa (CF by Andrés Hoyos. Each one of these books suggests two very different destinies for the Colombian nation in accordance with its nation-founding inspiration: the first one, seeking unity at any price with Bolivar’s image on the background, and the other one, that acknowledges the required fragmentation of the discourses and the value found in the version of the defeated. This way, these novels account for two visions of Colombia’s philosophy of history: one that depends on the wisdom of “important men” and the other that refers to partial discourses by social groups with vague objectives.

  13. Reconfiguración de alianzas políticas en contextos críticos: los caciques de San Andrés de Machaca (Pacajes, Audiencia de Charcas, siglos XV-XVII

    Directory of Open Access Journals (Sweden)

    Ariel Jorge Morrone

    2015-02-01

    Full Text Available Este trabajo explora las estrategias de reconfiguración política articuladas por los líderes étnicos de San Andrés de Machaca (actual provincia Ingavi, departamento de La Paz, Bolivia, en tres contextos críticos: la invasión incaica (a mediados del siglo xv, la sistematización del orden colonial hispánico (fines del siglo xvi y el desarrollo posterior de este sistema (primera mitad del siglo xvii. Cada situación definió nuevas reglas del juego político, ante las cuales las autoridades étnicas apelaron a una variedad de prácticas: la reorganización territorial, la asignación de recursos (de consumo y de prestigio, los rituales de negociación, la memoria genealógica y el tramado de redes personales.

  14. André Charrak, Contingence et nécessité des lois de la nature. La philosophie seconde des Lumières, Paris, Vrin, 2006, 224 pages, 26 €.

    Directory of Open Access Journals (Sweden)

    Raphaële Andrault

    2009-04-01

    Full Text Available Quel est le statut des lois de la nature ? Telle est la question posée dans ce livre d’André Charrak. L’auteur montre que la philosophie des Lumières envisage le problème de la connaissance sous l’angle de « l’application des principes aux phénomènes et des sciences les unes aux autres » (p. 199 et qu’il existe un lien direct entre la possibilité de l’application de la mathématique à la physique dans les savoirs positifs et les partis pris explicites sur le statut modal des lois du mouvement...

  15. Projeto político-pedagógico na creche: participação e protagonismo da equipe de funcionárias(os) de uma unidade da rede municipal de santo andré.

    OpenAIRE

    Vieira, Ana Luzia da Silva

    2015-01-01

    Esta pesquisa-intervenção analisa como professoras e funcionárias(os) compreendem a participação, o pertencimento e o protagonismo das(os) funcionárias(os) no processo de elaboração e acompanhamento do Projeto Político-Pedagógico (PPP) da creche no decorrer dos anos 2013, 2014 e 2015, ressaltando que a própria pesquisadora encontra-se na condição de diretora da unidade escolar. O universo da pesquisa é uma creche com crianças de zero a três anos de idade, localizada na cidade de Santo André-...

  16. From Ceylon to Constantinople: Andrés de Noronha’s Advertimiento, Felipe Botello’s Memorandum, and the Apocryphal Correspondence between the Jews of Spain and those of Constantinople

    Directory of Open Access Journals (Sweden)

    Fernando Bravo López

    2017-01-01

    Full Text Available In this article we throw new light on the Advertimiento that bishop Andrés de Noronha sent to Phillip II’s secretary, Mateo Vázquez, in 1584. This document has been presented by some historians as a very early evidence of the circulation of the famous apocryphal correspondence between the Jews of Spain and those of Constantinople. We analyse the Advertimiento by situating it in its context, thanks to the study of the correspondence that Noronha maintained with Vázquez. And finally, we analyse the document by comparing its content with that of the memorandum – unpublished until now – that the clergyman Felipe Botello handed to the inquisitor Martín de Salvatierra in 1569. Through that analysis we will demonstrate that almost all what Noronha said in his document was a forgery, a product of the misrepresentation of Botello’s memorandum.

  17. Análise dos efeitos da judicialização da política pública de educação infantil: o caso de Santo André (SP)

    OpenAIRE

    Santos, Marinella Burgos Pimentel dos

    2014-01-01

    O presente estudo tem como foco a análise dos efeitos da judicialização da política pública de Educação Infantil, com base nas informações referentes ao Município de Santo André, região metropolitana de São Paulo. O estudo traça um panorama geral sobre o processo de judicialização das políticas públicas e o marco referencial da Educação Infantil pública no Brasil. Em um segundo momento o estudo avança para a análise das informações sobre a influência da judicialização da política pública de c...

  18. Labor de Andrés Manuel del Río en México: profesor en el Real Seminario de Minería e innovador tecnológico en minas y ferrerías

    Directory of Open Access Journals (Sweden)

    Uribe Salas, José Alfredo

    2006-12-01

    Full Text Available This article analyzes the scientific and technological training of Andrés del Río in Europe and, his professional activities in New Spain at the end of the eighteenth and the beginning of the nine teenth century. I study his scientific practice at Mexico City’s Royal Mining Seminary as a form of culture; therefore, this research examines the «scientific practice» and goals of Andrés del Río from a historicist and cultural perspective. Del Río contributed to forge a scientific culture that became part of the collective imaginary in his new country of residence. However his direction in the draining of the Morán mines in the mining district of Real del Monte and the establishment of the ferrería (pre-industrial iron smelter of Guadalupe in the Coalcomán highlands, in the former Michoacán Bishopric, allowed him to show his abilities as a technician and his skill in the design, projection and execution of two engineering projects (one hydraulic, the other industrial—the first of their genre in the New World.

    El trabajo analiza la formación científica y tecnológica de Andrés del Río en Europa, y su desempeño profesional en Nueva España a fines del siglo XVIII y principios del XIX. Se estudia su práctica científica en el Real Seminario de Minería de la ciudad de México como una forma de cultura, y por lo tanto se examina la «práctica científica» de Andrés del Río y sus objetivos desde una perspectiva historicista y cultural. Del Río contribuyó a forjar una cultura científica como parte del imaginario colectivo del nuevo país de residencia. Pero serían los encargos de desaguar las minas de Morán en el distrito minero de Real del Monte y el establecimiento de una ferrería en la sierra de Coalcomán, en el antiguo Obispado de Michoacán, las que dejaron ver sus dotes de tecnólogo y la pericia en el diseño, proyección y ejecución de dos obras de ingeniería, una hidráulica y la otra industrial, las

  19. Narcotráfico, violencia y crisis social en el Caribe insular colombiano: El caso de la isla de San Andrés en el contexto del Gran Caribe

    Directory of Open Access Journals (Sweden)

    Silvia Mantilla

    2011-01-01

    Full Text Available El presente artículo tiene por objetivo presentar un diagnóstico preliminar de la magnitud del tráfico de drogas, sus dinámicas, modalidades, y las condiciones sociales y económicas que favorecen el desarrollo de este negocio ilegal en la isla de San Andrés (Colombia. El análisis se desarrolla, no obstante, en el marco de la condición histórica y natural de “zona de tránsito” de drogas, armas y otros recursos ilegales, que se le atribuye a la región del Gran Caribe, entendida como un continuo geográfico, histórico y cultural en el que se observan patrones comunes en materia de amenazas a la seguridad, la geopolítica de las relaciones con Estados Unidos y los efectos sociales y económicos derivados del flagelo del narcotráfico. En este sentido, el caso de la isla de San Andrés (Colombia se examina más como parte de la dinámica insular gran caribeña que como parte de las tendencias propias del negocio en la Colombia continental, lo que permite, sin embargo, establecer las conexiones entre ambos espacios regionales - el insular y el continental - y, a la vez, evaluar el impacto regional del fenómeno a partir de las conexiones ilegales que desde el archipiélago se establecen con algunos países vecinos del Gran Caribe. Finalmente, se sostiene la hipótesis de que el fenómeno del narcotráfico se instala en la isla como resultado de factores geohistóricos, culturales y socioeconómicos que en conjunto han determinado la participación activa de distintos sectores de la sociedad en este negocio ilegal.

  20. A municipalização das ações de saúde e a assistência hospitalar: as respostas de Santo André e Diadema (1989-1992

    Directory of Open Access Journals (Sweden)

    Vânia Barbosa do Nascimento

    1996-01-01

    Full Text Available A oferta de serviços hospitalares diante do recente processo político-administrativo de descentralização e municipalização da saúde no Brasil surge como um desafio à gestão local. Produzir respostas imediatas, num contexto dinâmico, acelerado e não linear de incorporação política dos direitos sociais, associado à complexidade que envolve a assistência médico-hospitalar, conduz a uma necessária reflexão acerca das potencialidades e limites das diretrizes da atual política de saúde. As diferentes trajetórias do desenvolvimento dos projetos para a gestão de serviços hospitalares nos municípios de Santo André e Diadema inovam, diante dos aspectos conceituais e políticos da descentralização, as responsabilidade do poder local, apesar da complexidade da questão.The offering of hospital services in face of the recent politico-administrative decentralisation and municipalization of health process on Brazil comes up as a challenge to local management. The production of immediate responses within a dynamic accelerated non-linear context of political incorporation of social rights given the complexity involving medico-hospital assistance leads to a necessary reflection on the potentialities and limits of the directives of the current health policy. Despite the complexity of the issue the different trajectories of the hospital services management project development in the municipalities of Santo André and Diadema innovate the responsibilities of local power to meet the conceptual and political aspects of decentralisation.

  1. Uso de esteróides andrógenos anabólicos por praticantes de atividade física das principais academias de Erechim e Passo Fundo/RS

    Directory of Open Access Journals (Sweden)

    F. FRIZON

    2009-01-01

    Full Text Available

    Os esteróides andrógenos anabólicos (EAA são substâncias quimicamente semelhantes à testosterona e que teriam a propriedade de aumentar a força e a massa muscular. Apesar de estarem associados a uma série de efeitos nocivos, principalmente sobre os sistemas cardiovascular, hepático e neuro-endócrino, verifica-se que o abuso de EAA tem aumentado consideravelmente nos últimos anos. No presente trabalho, o perfil dos praticantes de atividade física das academias de Erechim e Passo Fundo/RS e a incidência de uso de EAA foram verificados. Responderam aos questionários 418 praticantes de atividade física, de um total de 700 questionários distribuídos. A percentagem de uso foi de 6,5%; todos usuários do sexo masculino, de uma população de 83% de homens. O EAA mais utilizado foi o decanoato de nandrolona (35,29%. Os EAA foram adquiridos em farmácias com receita médica (37,04%. O perfil dos praticantes pode ser assim delineado: idade entre 21 e 25 anos, homens, estudantes universitários (62,67% e motivados por estética e ganho de força. Este estudo ressalta a necessidade de ações preventivas e educativas junto à população jovem. Palavras-chave: Esteróides andrógenos anabólicos, atividade física, estética.

  2. LA CONSTRUCCIÓN COMO FRONTERA DE LA FORMA: EL LABERINTO DE ANDRÉ BLOC EN CARBONERAS / A construction as a frontier of form: the labyrinth of André Bloc in Carboneras

    Directory of Open Access Journals (Sweden)

    Héctor García-Diego Villarías, María Villanueva Fernández

    2013-05-01

    Full Text Available RESUMEN El polifacético arquitecto de origen argelino André Bloc, tras ensayar en varias ocasiones en su jardín de Meudon algunas soluciones plásticas habitables, insertó una de sus esculturas habitáculo en una de las playas almerienses de Carboneras. La construcción, conocida popularmente como ‘El Laberinto’, constituye una obra singular del patrimonio arquitectónico español del siglo pasado y una muestra ejemplar del esfuerzo de integración entre arte y arquitectura. Pero sobre todo, esta insólita vivienda supone un testimonio extraordinario respecto a la frontera que separa arte y arquitectura y restringe una hipotética coalescencia entre ambas: el hecho constructivo marca un límite que, aunque variable, resulta ineludible.SUMMARY After trying some habitable, sculptural solutions in his garden at Meudon, on several occasions, the multifaceted architect of Algerian origin, André Bloc, built one of his habitable sculptures at one of the beaches of Carboneras, in Almeria. The construction, popularly known as “The Labyrinth”, constitutes a unique work from the Spanish architectural heritage of the last century and is a prime example of the force of integration between art and architecture. However, above all, this unusual house represents an extraordinary testimony with respect to the frontier that separates art and architecture and which restricts a hypothetical coalescence between both; the constructive fact defines a boundary which, although variable, is inescapable.

  3. Proyecto de un servicio funcional a prestar en una biblioteca universitaria: "El Servicio de Información Departamental" de la Biblioteca Max von Buch (Universidad de San Andrés

    Directory of Open Access Journals (Sweden)

    Moira Guppy

    2001-06-01

    Full Text Available Este trabajo -elaborado para el Seminario "La organización de los Servicios al Público en la Biblioteca" (UBA, 1998- describe el proyecto de un servicio a desarrollar en la Biblioteca Max von Buch de la Universidad de San Andrés. El "Servicio de Información Departamental" ofrecerá a los docentes e investigadores acceso a los recursos disponibles dentro de su área temática (Internet, bases de datos, índices de artículos de publicaciones periódicas, revistas en texto completo, series estadísticas, etc. Estará elaborado en dos formatos: un cd-rom actualizado periódicamente, y una página Web en línea especialmente diseñada. Con la implementación de este servicio se logrará un gran ahorro de tiempo en la búsqueda, análisis, tratamiento y difusión de la información destinada a la investigación académica.This paper -presented at the seminary "Public Services Organization at the Library"- describes a project to be developed at the Max von Buch Library, Universidad de San Andrés. The "Academic Information Service" would be design to provide access to researchers and faculty to all the resources available whithin each discipline and research area in the Internet, databases, periodical indexes, full text periodicals, statistical data, etc. They will gain access to it from a cd-rom which would be updated periodically, and a web page specially designed. The implementation of this project would provide faculty with qualified information along with considerable time saving in their researches.

  4. Conocimiento sobre el fenómeno de las drogas en entre estudiantes y docentes de la Facultad de Medicina Universidad Mayor de San Andrés, La Paz, Bolivia Conhecimento sobre o fenômeno das drogas entre estudantes e docentes da Faculdade de Medicina da Universidade Mayor de San Andrés, La Paz, Bolívia Knowledge on drugs phenomenon by students and faculty from the Medical School at Universidad Mayor de San Andrés, La Paz, Bolivia

    Directory of Open Access Journals (Sweden)

    Maria del Pilar Navia-Bueno

    2011-06-01

    Full Text Available El objetivo de este estudio fue identificar el grado de conocimiento de los estudiantes y docentes de salud sobre drogas lícitas e ilícitas, relacionadas a: tipo, clasificación, acción, mecanismos, daños, consecuencias y efectos adversos además del uso y consumo. El diseño metodológico fue de "corte transversal, con una muestra de 172 estudiantes, profesores y residentes de las áreas de medicina y enfermería de la Universidad Mayor de San Andrés (UMSA, en Bolivia. Los resultados revelan que existe una debilidad en cuanto al conocimiento en relación a la clasificación de sustancias psicotrópicas de acuerdo con la estructura, propiedad química y efectos que producen en la salud, destacándose una diferencia significativa del conocimiento sobre drogas lícitas, como el alcohol y tabaco, con las drogas ilícitas. Se resalta el desconocimiento en todo el grupo estudiado sobre drogas lícitas e ilícitas, consecuencias y efectos adversos, lo que confirma la necesidad de mejorar la enseñanza en este contenido en las escuelas de salud.O objetivo deste estudo foi identificar o grau de conhecimento dos estudantes e professores da área da saúde sobre drogas lícitas e ilícitas, em relação ao tipo, classificação, mecanismos de ação, danos, consequências e efeitos adversos, decorrentes de seu consumo. Trata-se de estudo de coorte transversal, com amostra de 172 estudantes, professores e residentes das áreas de medicina e enfermagem da Universidad Mayor de San Andrés (UMSA, Bolívia. Os resultados revelam baixo nível de conhecimento dos sujeitos da investigação, relacionado à classificação de substâncias psicotrópicas, quanto à estrutura, propriedade química e efeitos que produzem na saúde, destacando-se diferença significativa entre o conhecimento sobre drogas lícitas, como álcool e tabaco, e drogas ilícitas. Ressalta-se o desconhecimento de todos os sujeitos da investigação sobre drogas lícitas e il

  5. Evaluation of underground water contamination of tubular wells, by fuels oil in Santo Andre City, Sao Paulo state: a contribution to the environmental management; Avaliacao da contaminacao da agua subterranea de pocos tubulares, por combustiveis fosseis, no municipio de Santo Andre, Sao Paulo: uma contribuicao a gestao ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Mindrisz, Ana Copat

    2006-07-01

    The contamination of underground waters by hydrocarbons originated from gas stations has been object of increasing preoccupation in environmental organization all over the world. The organic compounds Benzene, Toluene, Ethylbenzene and Xylene (BTEX), present in these fuels, are extremely toxic to human health and could make impracticable the exploration of these contaminated waters by these kinds of pollutants and consequently the gasoline wells used for this purpose. In this work, it was carried out a diagnosis of the water quality with information and analyses, with the goals to snap shot the situation of the wells destined to domestic and commercial supply of water in the urban area of Santo Andre city, Sao Paulo state. There have been evaluated the presence of micron pollutants BTEX, after contamination due to leaks in fuel storage tanks close to the wells, in different places of the city. The physical chemistry parameters like color, turbidity and residual chlorine were also evaluated as well as trace elements, metals, anions like fluorine, sulphates, chlorine, nitrates and phosphates and bacteriological (total coliforms, thermo stable coliforms, heterotrophic bacteria). On definition of the sampling area, it was sought, at first, the evaluation of environmental contaminations historical series by gas stations, evaluating the set of information available at government environmental organizations and spatial representatively of the problem. For administration of the underground water quality it was adopted the methodology used by Companhia de Tecnologia de Saneamento Ambiental (CETESB), being accomplished a previous identification of contaminated potential areas and organizing a data base on landfills disposal and neglected places; registration of gas station services and, wells used by the population, industrial inventory with active and neglected maps taking into consideration the size and residues generation (such as SEMASA), prioritizing in this way the

  6. Relação entre situação social e crescimento físico, numa população infantil de Santo André, SP, Brasil Relationship between social situation and physical growth in children from Santo Andre, State of S. Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Maria Stella Ferreira Levy

    1977-09-01

    Full Text Available Baseado em dados sócio-antropológicos e em medidas antropométricas coletados no Município de Santo André, Estado de São Paulo, Brasil, foi analisada a população infantil de ambos os sexos e de treze idades diferentes (0, 3, 6 e 9 meses, 1 ano, 1 ano e meio, 2 a 8 anos. Foram utilizadas 3 variáveis independentes ISSE - índice de situação sócio-econômica da família (baseado nas inter-relações da média de gasto familiar mensal "per capita" e a instrução e ocupação do chefe da casa; CATANCES - construída a partir da informação sobre a nacionalidade dos ascendentes das crianças até 3ª geração; e Tamanho do Grupo Residencial. Como variáveis dependentes, utilizou-se a estatura, o peso e o Índice de Kaup. Considerando a relação positiva entre melhores condições de vida e desenvolvimento físico, constatou-se (através do teste de ordenação de médias de Duncan que, embora as médias das medidas diferissem segundo as variáveis independentes, isso não acontecia igualmente nas mesmas idades e nos dois sexos. Observou-se pelos resultados das análises de variância, na maioria das vezes significantes, que as variáveis selecionadas explicavam muito pouco da variação das medidas nas várias idades e sexos. Conclui-se que a amostra estudada, segundo as variáveis independentes deste estudo, difere entre idades em ambos os sexos. Isto levanta uma série de questões sobre quais as variáveis mais adequadas a estudos desse gênero. Sugere-se, consideradas as duas categorias de variável CATANCES, a utilização de duas "tabela padrão" para peso e altura, segundo regiões brasileiras. Quanto ao índice de Kaup, evidenciou-se a necessidade de ser encontrada uma função matemática específica para cada idade, uma vez que, ao menos em relação a crianças em crescimento, o índice não media aquilo a que se propunha.This article was based on some of the data collected in the county of Santo André, State of Sew Paulo

  7. Fatores Associados à Obesidade e ao Padrão Andróide de Distribuição da Gordura Corporal em Mulheres Climatéricas Factors Related to Obesity and Android Pattern of Body Fat Distribution in Climacteric Women

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    Diana Beatriz Filip Raskin

    2000-08-01

    Full Text Available Objetivos: descrever as características de um grupo de mulheres climatéricas, conhecer a freqüência e os fatores associados à obesidade e ao padrão andróide de distribuição da gordura corporal. Métodos: estudo observacional com 518 pacientes com idade entre 45 e 65 anos em um ambulatório de climatério. Foram considerados a idade, cor, status menopausal, tempo de menopausa, atividade física, tabagismo, dieta, etilismo, antecedentes pessoais e familiares de hipertensão, diabetes, doença cardiovascular, dislipidemia e obesidade. O índice de massa corpórea e a relação das medidas cintura/quadril foram variáveis dependentes. Na análise estatística utilizaram-se os testes de Wilcoxon, c² de Pearson, com nível de significância de 5%, e análise múltipla por regressão logística. Resultados: mais de dois terços das participantes eram não-obesas com perfil andróide e menopausadas. Aproximadamente um quarto tinha atividade física adequada, era tabagista, metade referiu dieta inadequada e um quinto era etilista. Pacientes com perfil andróide apresentaram média etária maior que mulheres com padrão ginecóide. Antecedentes pessoais de obesidade, hipertensão, diabetes e história familiar de diabetes relacionaram-se com obesidade e padrão andróide. O status pós-menopausa associou-se significativamente ao perfil andróide. Conclusões: a maioria das mulheres foram não-obesas com perfil andróide, brancas, pós-menopáusicas, sedentárias, não-tabagistas nem etilistas. Os principais fatores associados à obesidade e padrão andróide foram os antecedentes pessoais de obesidade, hipertensão arterial, diabetes, história familiar de diabetes e, particularmente, o status pós-menopausa com o perfil andróide.Purpose: to describe sociodemographic characteristics of a group of climacteric women in order to discover the frequency and the variables associated with obesity and android profile of body fat distribution. Methods

  8. An improved $\\pi$K atom lifetime measurement

    CERN Document Server

    Yazkov, V

    2016-01-01

    This note describes details of analysis of data samples collected by DIRAC experiment on a Pt target in 2007 and Ni targets in 2008–2010 in order to estimate the lifetime of πK atoms. Experimental results consist of eight distinct data samples: both charge combinations ( π + K − and K + π − atoms) obtained in different experimental conditions corresponding to each year of data taking. Estimations of systematic errors are presented. Taking into account both statistical and systematic uncertainties, the lifetime of πK atoms is estimated by the maximum likelihood method. The above sample comprises the total statistics, available for the analysis, thus the improvement over the previous estimation [1,3] of the πK atom lifetime is achieved.

  9. Os indígenas do Brasil entre a razão de Estado e o Direito Natural: as contribuições de André Thévet e Jean de Léry

    Directory of Open Access Journals (Sweden)

    Arno Wehling

    2012-12-01

    Full Text Available Análise da percepção, em André Thévet e Jean de Léry, das questões do estado de natureza, bondade natural e direito natural nos indígenas brasileiros com os quais os cronistas da França Antártica tiveram contato. Indaga-se se já existe nos autores clara consciência dessas questões, ou se foram deduzidas ou mesmo treslidas por autores posteriores, que já partiam de concepção apriorística sobre o assunto. Faz-se referência à trajetória do direito natural de Maquiavel a Locke, com a emergência de um novo jusracionalismo e são estudadas as informações dos dois autores. Conclui-se com a avaliação da recepção dos cronistas, do significado por eles atribuído às questões e ao papel do direito natural em seu discurso. Os textos aparecem então como elemento empírico num longo processo de estabelecimento do novo direito natural, o do "direito racional" na classificação de Bobbio, processo que por sua vez se conflita com outra doutrina emergente no século XVI - a da razão de Estado.

  10. Disputas marítimas en el Caribe colombiano: la pesca de tortugas en el archipiélago de San Andrés y Providencia, 1910-1930

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    Sharika Crawford

    2017-10-01

    Full Text Available There has been a long history of turtle hunting in the Greater Caribbean, especially in Colombian waters around the archipelago of San Andrés and Providence. This article is focused on Colombia’s efforts to affirm its national borders and to strengthen its control over its territorial waters, and on how the new regulations that these measures entail affect turtle hunters in the Caribbean Sea. Using travel stories, newspapers from Jamaica, Colombia and the United States, as well as diplomatic correspondence, interviews and secondary sources, this study analyzes the national and regional implications of these problems. This makes it possible to conclude that the islanders, in the company of Colombian officials, attempted to defend their insular territory and its maritime borders against both real and imaginary threats. Their efforts were aimed at restricting the extraction of marine resources within the country’s territorial waters, as part of the government’s interest in reinforcing the integrity of the Colombian nation-state in the Caribbean.

  11. 'Sidun' e 'Creuza de mâ' di Fabrizio De André (1940–1999. La svolta etnica del cantautore genovese attraverso l’analisi di due canzoni esemplari

    Directory of Open Access Journals (Sweden)

    Vanna Lovato

    2014-01-01

    Full Text Available L’album Creuza de mâ (1984 di Fabrizio De André, composto e registrato grazie alla fondamentale collaborazione del musicista Mauro Pagani, rappresenta un unicum nella storia della canzone italiana, ed è più in generale un buon esempio di canzone d’autore moderna rielaborata secondo parametri musicali e linguistici diversi dagli standard della canzone di consumo tipici dell’epoca in cui l’album venne pubblicato, anticipando di quasi un decennio in Italia la moda della cosiddetta world music. Pur confermandosi ad oggi uno dei migliori esempi di ‘contaminazione’ tra canzone popolare –– rappresentata qui dall’uso del dialetto genovese –– e tradizione musicale mediterranea , nel 1984 il disco fu accolto in modo tiepido dal pubblico , ma ottenne  subito il plauso della critica e di molti colleghi ed estimatori, italiani e non; ricordiamo, tra gli altri, gli apprezzamenti fatti nel corso degli anni dal musicista inglese David Byrne.

  12. Eficiencia energética en la trituración por impactos en la planta de zeolitas de San Andrés (Holguín, Cuba

    Directory of Open Access Journals (Sweden)

    José Ramón Hechavarría-Pérez

    2015-01-01

    Full Text Available El presente trabajo tiene como objetivo la evaluación a escala industrial de la eficiencia energética de una trituradora de ma rtillos en la planta de zeolitas de San Andrés. Variando los niveles de las v ariables de operación (velocidad del rotor, cantidad de martill os y productividad del triturador, se r ealizaron dos series de ensa yos para determinar su influencia en la potencia consumida por el motor de la trituradora; y la influencia sobre energía específica en tritur ación. El modelo del experimento obtenido de la primera serie d e ensayos demostró la influencia de las variables de operación en la pote ncia consumida por el motor de la trituradora. La relación entr e la energía consumida en la trituración y pro ductividad y velocidad de la t rituradora mostró su fuerte infl uencia en los indicadores energ o-tecnológicos. El régimen más eficiente corre sponde a los niveles de 1100rpm d e velocidad del rotor, 2 martillos y 15 t/h de productividad.

  13. Parâmetros de qualidade físico-químicos e avaliação da atividade antioxidante de folhas de Plectranthus barbatus Andr. (Lamiaceae submetidas a diferentes processos de secagem

    Directory of Open Access Journals (Sweden)

    C.F.G SILVA

    2016-03-01

    Full Text Available RESUMO O presente trabalho descreve a composição físico-química, a avaliação da atividade antioxidante pelo método de sequestro de radicais livres DPPH, determinação de flavonoides e de fenóis totais dos extratos etanol, acetona e aquoso de Plectranthus barbatus Andr. (Lamiaceae, desidratadas em secador solar e em estufa de circulação de ar a 60 oC. Os valores de atividade de água encontrados para as duas secagens foram inferiores ao mínimo necessário para o crescimento e produção de toxina de patógenos de importância alimentar. Os resultados das análises físico-químicas demonstraram que ambos os processos mostraram-se eficientes na desidratação de P. barbatus. Os resultados demonstraram que os extratos acetona (estufa e etanol (estufa e secador solar foram os que apresentaram maior conteúdo de fenóis totais. O extrato etanólico (estufa apresentou maior quantidade de flavonoides e melhor potencial antioxidante (IC50 = 75,71 ± 10,57 µg mL-1.

  14. Entre a sedução e a desconfiança: o jogo do autor e do leitor em Les Faux-Monnayeurs de André Gide

    Directory of Open Access Journals (Sweden)

    Isabelle Santos Bezerra

    2012-11-01

    Full Text Available O presente artigo visa a uma análise dos papéis do autor e do leitor na obra de André Gide, Les faux-monnayeurs. Por meio da discussão de alguns aspectos referentes aos estudos autobiográficos, às reflexões da estética da recepção e da teoria mimética de René Girard, propõe-se uma reflexão acerca da relação que pode haver entre um leitor ativo e o escritor. Além disso, propõe-se analisar de que forma a impressão de um relato autobiográfico permite uma reconfiguração da relação entre leitor e autor, gerando a possibilidade do estabelecimento entre eles de uma relação mimética.

  15. [The sustainability of day-to-day life: a study of the social networks of users of mental healthcare service in the municipality of Santo André (SP, Brazil)].

    Science.gov (United States)

    Muramoto, Melissa Tieko; Mângia, Elisabete Ferreira

    2011-04-01

    Studies into social networks show that relationships have a significant impact on people's lives. When associated with the population suffering from mental disorders, they serve as an important protection factor and a manager of resources and social support. However, studies show that people with mental disorders have impoverished social networks and few significant relationships. In this perspective, this research sought to characterize the social networks of users of NAPS II in Santo André (SP, Brazil). Conducted in 2006, the qualitative research adopted an ethnographic approach and used interviews by topics, participant observation and field notes. The results revealed that the group studied had an impoverished social network; the life histories of the subjects is related to this impoverishment, since the disruptions caused by situations of crisis or institutionalization removed them from the network of relationships, placing them in a situation of social vulnerability. An attempt was made to address the importance of intervention in the relationships and the role of the services in this process.

  16. Manuel Grijalvo, Un Obispo Burgales en Filipinas. By Roberto Blanco Andrés. Burgos: Publicaciones de la Excma. Diputación de Burgos, 2011. 88 pages, plates.

    Directory of Open Access Journals (Sweden)

    Grace Liza Y. Concepcion

    2012-12-01

    Full Text Available This brief biography is one among many published works by RobertoBlanco Andrés, a Spanish historian who specializes in the history of religious orders in the Philippines, particularly the Augustinians. The aim of the present work is simple. It is to recount Fray Manuel Grijalvo’s life as a religious priest who occupied key positions in the Augustinian Order and in the Philippine church as bishop of Nueva Caceres (now Naga in the first half of the 19th century, at a time when both the Order and the church in the Philippines were undergoing transition. This succinct narration of an Augustinian bishop’s lifeopens a window through which one can appreciate Philippine history in the 19th century. Although brief, the summary of Grijalvo’s years in the Philippines, spent in Manila and Nueva Caceres, gives a relatively complete view of the challenges that the Catholic Church was facing in this era, both within the Augustinian Order and in the Diocese of Nueva Caceres. This is so because Grijalvo was an Augustinian missionary who also occupied key posts as parish priest in Batangas towns (1814 -1818 and in Pasig (1833 -1839 and 1831-1847. He was also procurator and prior of the Order between 1818 and 1832. In1848, he was appointed bishop of Nueva Caceres, a post he occupied until his death in 1861. His life, therefore, encapsulates the struggles and challenges of the Philippine Catholic Church and the Spanish colonial government.

  17. Application of the Educaplay Computer Technique as a Strategy for the Learning of Biomolecules, in the Students Bachelor of the Educational Unit Andrés F. Córdova - Cañar, Ecuador

    Directory of Open Access Journals (Sweden)

    Manuel Eduardo Collaguazo Álvarez

    2017-11-01

    Full Text Available The general objective of the investigation is to demonstrate that the application of the informatic technique Educaplay, as a strategy, contributes to the learning of the Biomolecules in students of the first year of the bachelorship of the Unidad Educativa Andrés F. Córdova. The study was developed under a quantitative focus, quasi experimental design, the collection data were made through the survey and tests, having as data collection tools the questionnaires and the objective test. The hypothetical deductive and the statistical methods were used in the study, verifying the hypothesis by means of the statistic Z for two samples, with values of z=6.67 and z=1.64. Therefore, the investigation hypothesis is accepted, concluding that the application of the Educaplay computer tool through: crosswords, interactive maps and video quiz, contributes significantly to the learning of the biomolecules, emphasizing the academic performance in the experimental group with an average of 8.56 /10, in Where the majority of students reach the required learning and many are projected to dominate them in comparison to the control group whose value is 6.51 /10.

  18. Utopías y nacionalismo cultural en América Latina. La interpretación de Andrés Sabella a la contribución de Mariátegui, Vallejo y Eguren

    Directory of Open Access Journals (Sweden)

    José Antonio González Pizarro

    2012-01-01

    Full Text Available Se hace una relectura de los autores peruanos José Carlos Mariátegui, César Vallejo y José María Eguren, desde la visión del poeta y ensayista chileno Andrés Sabella, poniendo el énfasis en la noción de utopía —como lo no lugar, lo imposible— no solamente en el ámbito político-económico sino desde la construcción de un “mundo” donde la imaginación, la ensoñación, pueda edificar en la niñez, una visión contra la fealdad, lo monocromático, estableciendo con fuertes imágenes líricas el “mundo imposible” de lo que se estimaba lo “perdido” en la infancia. La interpretación de Sabella —al igual que los textos de los autores peruanos— se sitúa en un contexto de la construcción de un nacionalismo cultural en el continente, como correlato de la búsqueda de una identidad latinoamericana expresiva de la diferencia con los Estados Unidos.

  19. Valoración del servicio ambiental hidrológico en el sector doméstico de San Andrés Tuxtla, Veracruz, México

    Directory of Open Access Journals (Sweden)

    Ana Lid del Ángel Pérez

    2009-01-01

    Full Text Available Entre las iniciativas de conservación en México, existe un programa de pago por servicios ambientales en áreas de gran importancia por sus valores ecológicos. Un caso es el de San Andrés Tuxtla, Veracruz, donde el pago no representa una opción económica sostenible a los dueños de predios, por lo que deberá incorporarse también el reconocimiento social. El objetivo del trabajo fue obtener el valor del bosque y paisajes alternativos en la población que recibe sus beneficios en forma de agua. Se realizó trabajo de campo y fueron aplicadas 241 encuestas. Se usó el método de valoración contingente y se incluyeron fotografías de paisajes alternativos a bosque, calificadas en función de su importancia para la economía y la conservación. Se obtuvo la disposición positiva a pagar por mantener el dosel, asociada a ciertas características de la población donde sobresalen ingreso, escolaridad y edad; los datos muestran que el pago deberá considerar valores económicos como costo de oportunidad y reforestación, además del reconocimiento social.

  20. A “INVENÇÃO DO TRABALHO”: historicidade de um conceito nas obras de André Gorz, Dominique Méda, Françoise Gollain e Serge Latouche

    Directory of Open Access Journals (Sweden)

    Nuno Miguel Cardoso Machado

    Full Text Available Após a publicação de Adeus ao Proletariado, em 1980, o entendimento do trabalho como uma atividade historicamente específica da modernidade capitalista é uma das traves-mestras do edifício teórico construído por André Gorz. O trabalho está intimamente associado ao surgimento de uma esfera econômica desvinculada da sociedade e, na qualidade de trabalho abstrato, ao fim, em si mesmo irracional, da valorização do valor. Neste artigo, pretendemos caracterizar detalhadamente a evolução do conceito de trabalho nas principais obras de Gorz e, depois, comparar a noção gorziana acerca da historicidade do trabalho com as ideias de três autores francófonos: Dominique Méda, Françoise Gollain e Serge Latouche. Procuraremos aferir as semelhanças e as divergências entre os autores mencionados. Finalmente, será salientado que as razões aventadas para o devir histórico do trabalho podem ser mais bem entendidas no contexto embrionário comum da “revolução militar”, no século XVI, que inaugurou a era moderna no mundo ocidental.