WorldWideScience

Sample records for reut andres pik

  1. Reactor PIK construction

    International Nuclear Information System (INIS)

    Konoplev, Kir

    2003-01-01

    The construction work at the 100 MW researches reactor PIK in year 2002 was in progress. The main activity was concentrated on mechanical, ventilation and electrical equipment. Some systems and subsystems are under adjustment. Hydraulic driving gear for beam shutters are finished in installation, rinsing, and adjusting. Regulating rods test assembling was done. On the critical assembly the first reactor fueling was tested to evaluate the starting neutron source intensity and a sufficiency of existing control and instrument board. Mainline of the PIK facility design and neutron parameters are presented. (author)

  2. PIK reactor construction status

    International Nuclear Information System (INIS)

    Konoplev, K.A.; Smolsky, S.L.

    2001-01-01

    The 100MW reactor PIK for fundamental researches has a thermal neutron flux of more than 10 15 n/cm 2 sec. This presentation outlines the construction state as of 2001, its prospects and completion tactics in the conditions of unstable finance. Construction of the reactor started in 1976. In 1986 construction of the building was completed and significant part of the installation work fulfilled. Construction of cooling systems was finished, the control panel assembled, and adjustment of the pump and gate valve control circuits started. After Chernobyl catastrophe, the USSR nuclear reactor safety requirements were revised. The PIK design did not meet these requirements and underwent considerable revision. The reconstruction design resulted in double the initial cost. Creation of the containment was the bulkiest part of the reconstruction. It brought about the need to disassemble the roofing of the building, dismantle all the equipment of the two upper floors, and lay up the equipment of the lower floors. As of 2001, construction in accordance with the revised design is at the stage of assemblage of the most important units, i.e. reactor itself, cooling system, heavy water system, and a number of auxiliary systems, such as depleted fuel storage, emergency cooling system etc. (orig.)

  3. Peapiiskop Andres Põderi jutlus / Andres Põder

    Index Scriptorium Estoniae

    Põder, Andres, 1949-

    2005-01-01

    Peapiiskop Andres Põderi jutlus oma ametissepühitsemise jumalateenistusel 2. veebruaril. Ilmunud ka: Põder, Andres. Pärimuste pöördepunkt : kõned ja kirjutised. - Tallinn : Kunst, 2007, 107-112

  4. Andres Ehin Jaapanist Iirini

    Index Scriptorium Estoniae

    2006-01-01

    Andres Ehin valiti Ülemaailmse Haiku Assotsiatsiooni auliikmeks ja kirjaniku inglisekeelset luulekogu "Moose Beetle Swallow" esitleti 2005. aasta Euroopa kultuuripealinnas Corkis Iirimaal. Järgneb: Looming 2006, nr. 2, lk. 311

  5. Andres Puustusmaa esikfilm Moskva filmifestivalil / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Eestist pärit režissööril Andres Puustusmaal esilinastub 29. juunil Moskva filmifestivali raames tema esimene täispikk mängufilm, Venemaa ja Ukraina ühistöö "Armastuse punane pärl" ("Krasnõi zhemtshug ljubvi"), peaosas Oksana Fandera, operaatoriks soomlane Timo Salminen. Valmis on ka teine mängufilm "1814", mis koos eespool nimetatuga tuleb kinodesse septembris. Ka Moskva festivali kavast

  6. Current status of the PIK Reactor

    International Nuclear Information System (INIS)

    Konoplev, K.A.

    1999-01-01

    At the end of 1998 the heads of the Russian Academy of Science, the Ministry of Science and Technology and the Ministry of Atomic Energy (the bodies involved in the research work with neutrons) declared the PIK-project as one of the objects of the first priority. They set a task to put it into operation in the next 3-4 years and to organize on its base an international center of neutron research. Realization of this task will depend on the real financing. In the last months there was a remarkable impulse in the construction work. In the frame of ISTC Project 321-96 Petersburg Nuclear Physics Institute and Research Institute of Technology developed functional training simulator (FTSC) for Reactor PIK. The utilization of FTSC for reactor PIK design examination began. (author)

  7. Comparative study of the chemical profiling, antioxidant and antimicrobial activities of essential oils of different parts of Thymus willdenowii Boiss & Reut.

    Science.gov (United States)

    Ouknin, Mohamed; Romane, Abderrahmane; Costa, Jean; Majidi, Lhou

    2018-02-27

    The analysis of Thymus willdenowii Boiss & Reut essential oils (TW EOs) shows 33 components accounting for (96.3-97.7%) of all identified. The main constituents of TW EOs were thymol (35.5-47.3%), p-cymene (13.9-23.8%), γ-terpinene (8.9-20.3%). The antioxidant assays revealed that all TW EOs tested showed strong activities, the antimicrobial effect of TW EOs has been tested against isolated clinical strains of Proteus mirabilis (ATCC 35659), Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231), Bacillus cereus (ATCC 10876), and Aspergillus brasilliensis (ATCC 16404). The antimicrobial test indicates that TW EOs show an inhibition effect against all the tested bacteria with a MIC of 6.9 to 27.6 μg/mL -1 . These results proving that the essential oils extracted from Thymus willdenowii Boiss & Reut may be a new potential source of natural antimicrobial applied in pharmaceutical and food industries.

  8. Gene of the month: PIK3CA.

    Science.gov (United States)

    Lai, K; Killingsworth, M C; Lee, C S

    2015-04-01

    PIK3CA encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) which through its role in the PI3K/Akt pathway is important for the regulation of important cellular functions such as proliferation, metabolism and protein synthesis, angiogenesis and apoptosis. Mutations in PIK3CA are known to be involved in a wide range of human cancers and mutant PIK3CA is thought to act as an oncogene. The specific PIK3CA inhibitor, NVP-BYL719, has displayed promising results in cancer therapy and is currently under clinical trials. Furthermore, PI3K regulates autophagy, a cellular process that recycles proteins and organelles through lysosomal degradation and has recently been recognised as an attractive therapeutic target due to its pro- and anti-cancer properties. Several studies have attempted to investigate the effects of combining the inhibition of both PI3K and autophagy in cancer therapy, and an in vivo model has demonstrated that the combined use of a concomitant PI3K and autophagy inhibitor induced apoptosis in glioma cells. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  9. Graafikatriennaali peapreemia Andres Talile

    Index Scriptorium Estoniae

    2001-01-01

    Tallinna XII graafikatriennaali preemiad: grand prix - Andres Tali; 3 võrdset preemiat - Janne Laine, Leonards Laganovskis, Peeter Laurits; diplomid - Lynne Allen, Lucrecia Urbano, Vladimir Tshaika, Zora Stanè, Endi Poskovic, Päivikki Kallio; EKM preemia - Tif Bitmap; Tallinna linna preemia - Ülle Marks ja Jüri Kass; eripreemiad: - J. Laine (Eesti Pank), Vive Tolli (Paletti Eesti AS), Martins Ratniksh, Juris Boiko, T. Bitmap (Balteco AS). Žürii koosseis

  10. The state of the PIK reactor construction

    International Nuclear Information System (INIS)

    Konoplev, K.A.

    1995-01-01

    Principle concepts of the PIK reactor project were stated late in the 60's but its construction was started in 1976. By the year 1986 the initial project was realised by approximately 70% but then, after Chernobyl accident the construction was essentially frozen to adjust the project to the revised nuclear safety regulations. The revised project was approved only in 1990 when the country was on the threshold of serious economic problems. The PIK reactor is a source of neutrons placed in the heavy water reflector. The fuel is uranium-235 (90% enrichment) of total weight 27 kg. Light water is used as moderator and coolant. Design parameters: thermal power is 100 W; thermal neutron flux in the reflector is 1.2x10 15 n/cm 2 s; in the central vertical beam tube is 5x10 15 n/cm 2 s; number of horizontal beam tubes is 10; diameter of beam tubes is 10 cm, with the possibility of replacement with beam tubes up to 25 cm in diameter. The reactor will be equipped with sources of hot, cold, and ultracold neutrons to obtain beams in different intervals of energy spectrum. The low temperature circuit will enable to irradiate samples at helium temperatures. The reactor has three series cooling circuits. Emergency core cooling systems in LOCA are double and in emergency power supply system is triple. The PIK reactor has no single common containment but four separate systems: for pipelines and units of the first circuit, for heavy water reflector, for operating hall, and for experimental beam tubes hall

  11. Burnable absorber for the PIK reactor

    International Nuclear Information System (INIS)

    Gostev, V.V.; Smolskii, S.L.; Tchmshkyan, D.V.; Zakharov, A.S.; Zvezdkin, V.S.; Konoplev, K.A.

    1998-01-01

    In the reactor PIK design a burnable absorber is not used and the cycle duration is limited by the rods weight. Designed cycle time is two weeks and seams to be not enough for the 100 MW power research reactor equipped by many neutron beams and experimental facilities. Relatively frequent reloading reduces the reactor time on full power and in this way increases the maintenance expenses. In the reactor core fuel elements well mastered by practice are used and its modification was not approved. We try to find the possibilities of installation in the core separate burnable elements to avoid poison of the fuel. It is possible to replace a part of the fuel elements by absorbers, since the fuel elements are relatively small (diameter 5.15mm, uranium 235 content 7.14g) and there are more then 3800 elements in the core. Nevertheless, replacing decreases the fuel burnup and its consumption. In the PIK fuel assembles a little part of the volume is occupied by the dumb elements to create a complete package of the assembles shroud, that is necessary in the hydraulic reasons. In the presented report the assessment of such a replacement is done. As a burnable material Gadolinium was selected. The measurements or the beginning of cycle were performed on the critical facility PIK. The burning calculation was confirmed by measurements on the 18MW reactor WWR-M. The results give the opportunity to twice the cycle duration. The proposed modification of the fuel assembles does not lead to alteration in the other reactor systems, but it touch the burned fuel reprocessing technology. (author)

  12. Present status of PIK gadolinium control

    International Nuclear Information System (INIS)

    Petrov, Yu.V.; Garusov, E.A.; Shustov, V.A.

    1994-01-01

    A liquid control element (LCE) containing a water solution of gadolinium nitrate Gd(NO 3 ) 3 was originally planned for use at the PIK reactor for partial compensation of poisoning and fuel burnup [1-3]. However, a further analysis has shown that quick forcing-out, boiling up or flowing-out of the absorbing solution (though of low probability) can lead to the dangerous prompt overcriticality of the reactor. The results of the analysis are presented as well as the upper limit of the reactivity, quick insertion of which still is safe for the reactor (J.P.N.)

  13. SANA - project results and PIK contributions

    Energy Technology Data Exchange (ETDEWEB)

    Bellmann, K; Erhard, M; Flechsig, M; Grote, R; Suckow, F

    1998-03-01

    This report includes the final project results of the two groups at PIK, involved in the project: Firstly, the newly developed physiologically-based forest growth model FORSANA was applied for the first time to three pine stands, which differed largely in their air pollution and deposition history. (The evaluation of the model is presented in PIK Report 32). The model was able to explain the growth during the last decades of at least two of the three stands from the climatic and deposition conditions at the sites. The third site was shown to be exceptional with respect to its relation between dimension and age, and was supposed to be exposed to major disturbances in the past, which could not be accounted for by the model. To extrapolate from the stand level to the regional level, FORSANA was initialised with spatially explicit data from forestry inventory and soil maps. Simulations were executed with measured weather records and regional distributions of deposition and air pollution, which were estimated on the basis of emission inventories and wind directions. Different assumptions about the development of air pollution had been applied to investigate different pollution abatement strategies. The results showed that a positive effect can be expected from the actual emission reductions close the main centres of emission, but showed also that this effect is decreasing with increasing distance from the emission source. (orig./KW)

  14. Andres Rõhu: kujundaja metsast / Andres Rõhu ; intervjueerinud Kaarel Kressa

    Index Scriptorium Estoniae

    Rõhu, Andres, 1965-

    2010-01-01

    Maalikunstnik Andres Rõhu sellest, kuidas temast sai raamatute kujundaja, parematest enda kujundatud raamatutest, südamelähedasematest eesti raamatukujundajatest, maal elamise eelistest. Loetletud A, Rõhu kujundatud teoseid

  15. Maailmaparandajad / Ole Ry, Susanne Andres

    Index Scriptorium Estoniae

    Ry, Ole

    2012-01-01

    Terapeudid Ole Ry ja Susanne Andres räägivad Dr David Berceli loodud TRE (Tension & Trauma Releasing Exercises) harjutuste kasutamise kogemusest erinevate psüühiliste traumade ja pingetega klientide tervise parandamisel

  16. The status of the PIK reactor

    Energy Technology Data Exchange (ETDEWEB)

    Petrov, Yu V [Academy of Sciences of Russia, Petersburg Nuclear Physics Institute, Gatchina, St. Petersburg (Russian Federation)

    1992-07-01

    This report describes the 100 MW research reactor PIK which is now under construction. The thermal neutron flux in the heavy water reflector exceeds 10{sup 15} cm{sup -2}s{sup -1}; in the light water trap, it is about 4{center_dot}10{sup 15} cm{sup -2}s{sup -1}. The replaceable core vessel allows to vary the parameters of the core over a wide range. The reactor provides sources of hot, cold and ultracold neutrons for 10 horizontal, 6 inclined neutron beams, and 8 neutron guides. At the ends of the beam tubes, the neutron flux is 10{sup 10} - 10{sup 11} cm{sup -2}s{sup -1}. The flux of the long wave neutrons exceeds 10{sup 9} cm{sup -2}s{sup -1}. To ensure precise measurements, the experimental hall is protected against vibrations. The project meets all modern safety requirements. The calculated parameters of the reactor were verified using a full-scale mock-up. Seventy percent of the reactor construction and installation were completed in the beginning of 1992. (author)

  17. Geim, Prof. Sir Andre Konstantin

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

  18. Suursaadik Andres Talvik : Prantsusmaa ei ole euroliidu laienemise pooldaja / Andres Talvik ; interv. Marianne Mikko

    Index Scriptorium Estoniae

    Talvik, Andres, 1947-

    2002-01-01

    Eesti suursaadik Prantsusmaal Andres Talvik Prantsusmaa presidendivalimistest, paremäärmuslase Jean-Marie Le Peni pääsemisest selle II vooru, prantslaste vastuseisust EL-i laienemisele, Prantsuse-Saksa suhetest. Andres Talviku elulooandmeid

  19. Mutations in PIK3CA are infrequent in neuroblastoma

    International Nuclear Information System (INIS)

    Dam, Vincent; Morgan, Brian T; Mazanek, Pavel; Hogarty, Michael D

    2006-01-01

    Neuroblastoma is a frequently lethal pediatric cancer in which MYCN genomic amplification is highly correlated with aggressive disease. Deregulated MYC genes require co-operative lesions to foster tumourigenesis and both direct and indirect evidence support activated Ras signaling for this purpose in many cancers. Yet Ras genes and Braf, while often activated in cancer cells, are infrequent targets for activation in neuroblastoma. Recently, the Ras effector PIK3CA was shown to be activated in diverse human cancers. We therefore assessed PIK3CA for mutation in human neuroblastomas, as well as in neuroblastomas arising in transgenic mice with MYCN overexpressed in neural-crest tissues. In this murine model we additionally surveyed for Ras family and Braf mutations as these have not been previously reported. Sixty-nine human neuroblastomas (42 primary tumors and 27 cell lines) were sequenced for PIK3CA activating mutations within the C2, helical and kinase domain 'hot spots' where 80% of mutations cluster. Constitutional DNA was sequenced in cases with confirmed alterations to assess for germline or somatic acquisition. Additionally, Ras family members (Hras1, Kras2 and Nras) and the downstream effectors Pik3ca and Braf, were sequenced from twenty-five neuroblastomas arising in neuroblastoma-prone transgenic mice. We identified mutations in the PIK3CA gene in 2 of 69 human neuroblastomas (2.9%). Neither mutation (R524M and E982D) has been studied to date for effects on lipid kinase activity. Though both occurred in tumors with MYCN amplification the overall rate of PIK3CA mutations in MYCN amplified and single-copy tumors did not differ appreciably (2 of 31 versus 0 of 38, respectively). Further, no activating mutations were identified in a survey of Ras signal transduction genes (including Hras1, Kras2, Nras, Pik3ca, or Braf genes) in twenty-five neuroblastic tumors arising in the MYCN-initiated transgenic mouse model. These data suggest that activating

  20. Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.

    Science.gov (United States)

    Gu, Mancang; Nishihara, Reiko; Chen, Yang; Li, Wanwan; Shi, Yan; Masugi, Yohei; Hamada, Tsuyoshi; Kosumi, Keisuke; Liu, Li; da Silva, Annacarolina; Nowak, Jonathan A; Twombly, Tyler; Du, Chunxia; Koh, Hideo; Li, Wenbin; Meyerhardt, Jeffrey A; Wolpin, Brian M; Giannakis, Marios; Aguirre, Andrew J; Bass, Adam J; Drew, David A; Chan, Andrew T; Fuchs, Charles S; Qian, Zhi Rong; Ogino, Shuji

    2017-10-20

    Evidence suggests that nonsteroidal anti-inflammatory drug aspirin (acetylsalicylic acid) may improve patient survival in PIK3CA -mutant colorectal carcinoma, but not in PIK3CA -wild-type carcinoma. However, whether aspirin directly influences the viability of PIK3CA -mutant colon cancer cells is poorly understood. We conducted in vitro experiments to test our hypothesis that the anti-proliferative activity of aspirin might be stronger for PIK3CA -mutant colon cancer cells than for PIK3CA -wild-type colon cancer cells. We measured the anti-proliferative effect of aspirin at physiologic concentrations in seven PIK3CA -mutant and six PIK3CA -wild-type human colon cancer cell lines. After exposure to aspirin, the apoptotic index and cell cycle phase of colon cancer cells were assessed. In addition, the effect of aspirin was examined in parental SW48 cells and SW48 cell clones with individual knock-in PIK3CA mutations of either c.3140A>G (p.H1047R) or c.1633G>A (p.E545K). Aspirin induced greater dose-dependent loss of cell viability in PIK3CA -mutant cells than in PIK3CA -wild-type cells after treatment for 48 and 72 hours. Aspirin treatment also led to higher proportions of apoptotic cells and G0/G1 phase arrest in PIK3CA -mutant cells than in PIK3CA -wild-type cells. Aspirin treatment of isogenic SW48 cells carrying a PIK3CA mutation, either c.3140A>G (p.H1047R) or c.1633G>A (p. E545K), resulted in a more significant loss of cell viability compared to wild-type controls. Our findings indicate that aspirin causes cell cycle arrest, induces apoptosis, and leads to loss of cell viability more profoundly in PIK3CA -mutated colon cancer cells than in PIK3CA -wild-type colon cancer cells. These findings support the use of aspirin to treat patients with PIK3CA -mutant colon cancer.

  1. Vulkaner andre steder i Solsystemet

    DEFF Research Database (Denmark)

    Haack, Henning

    2007-01-01

    Jupiters måne, Io, og man regner man med at Venus og formentlig også Mars stadig er vulkansk aktive. Ved at rette blikket ud i solsystemet har vi  mulighed for at studere vulkansk aktivitet under helt anderledes betingelser end her på Jorden. Hvad sker der f.eks., hvis tyngdekraften er svagere, eller...... planetens overflade måske er gloende varm? Vulkanerne andre steder i Solsystemet overgår på mange måder dem på Jorden. Venus er den planet i solsystemet, der har flest vulkaner, Mars har de største og højeste vulkaner, asteroiden Vesta har de ældste, og Jupiters måne Io har de mest aktive vulkaner i...

  2. Cafe Lyon = Cafe Lyon / Andres Labi

    Index Scriptorium Estoniae

    Labi, Andres, 1977-

    2013-01-01

    Cafe Lyon (Meistri 22, Tallinn) sisekujundusest. Autorid: Janno Roos, Andres Labi, Kristel Jakobson (Ruumilabor). Prantsuse Lütseumi direktori Lauri Leesi arvamus. Disainibüroo Ruumilabor lühitutvustus

  3. Andres Noormets - olemuselt luuletaja, vormilt lavastaja / Andres Noormets ; intervjueerinud Tiiu Laks

    Index Scriptorium Estoniae

    Noormets, Andres, 1963-

    2010-01-01

    Andres Noormets endast, oma lavastustest, näitlemisest ja lavastamisest, elu mõttest, uue otsimisest oma teatritöödega, sellest, mis endiselt paelub teatris ja praegusi teatritegemisi enim mõjutab, ise kirjutamisest jm. Andres Noormetsa eluloolisi andmeid

  4. Andres Ellamaa : suurperede seostamine asotsiaalsusega mõjub koletislikult / Andres Ellamaa ; interv. Indrek Veiserik

    Index Scriptorium Estoniae

    Ellamaa, Andres, 1944-

    2008-01-01

    Vestlus doktor Andres Ellamaaga suurperede toetamisest, kunstlikust viljastamisest. Lisaks: Kuidas kommenteerite dr. Andres Ellamaa 2. juuni Postimehes ilmunud artikli järel tekkinud diskussiooni avalikkuses ja meedias? Kommenteerivad Tallinna Arstide Liidu juhatuse liige Peeter Mardna ja Jõgeva haigla juhataja Peep Põdder

  5. PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations

    Directory of Open Access Journals (Sweden)

    Katsuhiko Nosho

    2008-06-01

    Full Text Available Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN. Microsatellite instability (MSI and CpG island methylator phenotype (CIMP are important molecular classifiers in colorectal cancer. However, the relationship between PIK3CA mutation, MSI and CIMP remains uncertain. Using Pyrosequencing technology, we detected PIK3CA mutations in 91 (15% of 590 population-based colorectal cancers. To determine CIMP status, we quantified DNA methylation in eight CIMP-specific promoters [CACNA1G, CDKN2A (p16, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1] by real-time polymerase chain reaction (MethyLight. PIK3CA mutation was significantly associated with mucinous tumors [P = .0002; odds ratio (OR = 2.44], KRAS mutation (P < .0001; OR = 2.68, CIMP-high (P = .03; OR = 2.08, phospho–ribosomal protein S6 expression (P = .002; OR = 2.19, and FASN expression (P = .02; OR = 1.85 and inversely with p53 expression (P = .01; OR = 0.54 and β-catenin (CTNNB1 alteration (P = .004; OR = 0.43. In addition, PIK3CA G-to-A mutations were associated with MGMT loss (P = .001; OR = 3.24 but not with MGMT promoter methylation. In conclusion, PIK3CA mutation is significantly associated with other key molecular events in colorectal cancer, and MGMT loss likely contributes to the development of PIK3CA G>A mutation. In addition, Pyrosequencing is useful in detecting PIK3CA mutation in archival paraffin tumor tissue. PIK3CA mutational data further emphasize heterogeneity of colorectal cancer at the molecular level.

  6. PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival.

    Directory of Open Access Journals (Sweden)

    Christophe Rosty

    Full Text Available Mutations in PIK3CA are present in 10 to 15% of colorectal carcinomas. We aimed to examine how PIK3CA mutations relate to other molecular alterations in colorectal carcinoma, to pathologic phenotype and survival. PIK3CA mutation testing was carried out using direct sequencing on 757 incident tumors from the Melbourne Collaborative Cohort Study. The status of O-6-methylguanine-DNA methyltransferase (MGMT was assessed using both immunohistochemistry and methyLight techniques. Microsatellite instability, CpG island phenotype (CIMP, KRAS and BRAF V600E mutation status, and pathology review features were derived from previous reports. PIK3CA mutation was observed in 105 of 757 (14% of carcinomas, characterized by location in the proximal colon (54% vs. 34%; P<0.001 and an increased frequency of KRAS mutation (48% vs. 25%; P<0.001. High-levels of CIMP were more frequently found in PIK3CA-mutated tumors compared with PIK3CA wild-type tumors (22% vs. 11%; P = 0.004. There was no difference in the prevalence of BRAF V600E mutation between these two tumor groups. PIK3CA-mutated tumors were associated with loss of MGMT expression (35% vs. 20%; P = 0.001 and the presence of tumor mucinous differentiation (54% vs. 32%; P<0.001. In patients with wild-type BRAF tumors, PIK3CA mutation was associated with poor survival (HR 1.51 95% CI 1.04-2.19, P = 0.03. In summary, PIK3CA-mutated colorectal carcinomas are more likely to develop in the proximal colon, to demonstrate high levels of CIMP, KRAS mutation and loss of MGMT expression. PIK3CA mutation also contributes to significantly decreased survival for patients with wild-type BRAF tumors.

  7. PT symmetric Aubry–Andre model

    International Nuclear Information System (INIS)

    Yuce, C.

    2014-01-01

    PT symmetric Aubry–Andre model describes an array of N coupled optical waveguides with position-dependent gain and loss. We show that the reality of the spectrum depends sensitively on the degree of quasi-periodicity for small number of lattice sites. We obtain the Hofstadter butterfly spectrum and discuss the existence of the phase transition from extended to localized states. We show that rapidly changing periodical gain/loss materials almost conserve the total intensity. - Highlights: • We show that PT symmetric Aubry–Andre model may have real spectrum. • We show that the reality of the spectrum depends sensitively on the degree of disorder. • We obtain the Hofstadter butterfly spectrum for PT symmetric Aubry–Andre model. • We discuss that phase transition from extended to localized states exists

  8. PT symmetric Aubry–Andre model

    Energy Technology Data Exchange (ETDEWEB)

    Yuce, C., E-mail: cyuce@anadolu.edu.tr

    2014-06-13

    PT symmetric Aubry–Andre model describes an array of N coupled optical waveguides with position-dependent gain and loss. We show that the reality of the spectrum depends sensitively on the degree of quasi-periodicity for small number of lattice sites. We obtain the Hofstadter butterfly spectrum and discuss the existence of the phase transition from extended to localized states. We show that rapidly changing periodical gain/loss materials almost conserve the total intensity. - Highlights: • We show that PT symmetric Aubry–Andre model may have real spectrum. • We show that the reality of the spectrum depends sensitively on the degree of disorder. • We obtain the Hofstadter butterfly spectrum for PT symmetric Aubry–Andre model. • We discuss that phase transition from extended to localized states exists.

  9. de Thymus fontanesii Boiss & Reut

    African Journals Online (AJOL)

    AKA BOKO

    Les huiles essentielles sont conservées à 4°C et à l'abri de la lumière. 2-3. Analyse physicochimique de l'huile essentielle du. Thymus fontanesii. Ces analyses sont faites en conformité aux normes A.F.N.O.R [4] Nous avons déterminé les: Caractères physiques : densité, indice de réfraction, pouvoir rotatoire, solubilité dans.

  10. Andre on alati tantsida tahtnud / Anu Mõttus

    Index Scriptorium Estoniae

    Mõttus, Anu

    2009-01-01

    Koolitantsu maakonnavoorud on peetud. Igast maakonnast pääsevad piirkonnavooru kuni pooled tantsud. Umbes sama edasipääsuprotsent on ka Andre Laine tantsudel, kelle koolitantsu vaimustus algas Kanepi Gümnaasiumi õpilasena ja kes praeguseks on selle gümnaasiumi tantsupedagoog

  11. André Petermann (1922-2011)

    CERN Multimedia

    2012-01-01

    The CERN theory community mourns the loss of André Petermann, one of the first members of the Theory Division, who passed away last August in his 89th year. He pioneered, together with his advisor Stueckelberg, the renormalization group, one of the fundamental ideas in quantum field theory that underlies the modern theory of phase transitions as well as asymptotic freedom and the quest for unification of all the particle interactions.   André was among the very first staff members of CERN, which at the beginning was a small group of theorists at the Niels Bohr Institute in Copenhagen, headed by Bohr himself.  When the group moved to Geneva, they first occupied a set of barracks in Cointrin, next to the airport, before moving to the University of Geneva, and then finally settling on the Meyrin site. André was our last direct contact with our nomadic origins. The importance of André’s early work on the renormalization group was recogn...

  12. André Rousset 1930-2001

    CERN Multimedia

    2001-01-01

    André Rousset in 1962 , seen working on BP3, one of the earlier bubble chambers, with André Lagarrigue (standing). André Rousset died on 1 July at the age of 70. For those who lived through the Gargamelle epic, his name is linked with the success of the great bubble chamber that made possible the 1973 discovery of neutral currents. A graduate of Paris's famous Ecole Polytechnique which produced so many great names in particle physics, André Rousset, a native of southern France, joined Louis Leprince-Ringuet's famous laboratory at the Polytechnique in 1954. Among other topics, Rousset played a part in the cosmic ray experiments at the Pic du Midi in the Pyrénées and designed heavy liquid bubble chambers. A Professor at the Ecole des Mines from 1960 onwards, he became deputy director of Louis Leprince-Ringuet's laboratory in 1964. In 1969 he came to CERN where, logically, he headed the TCL group in charge of heavy liquid bubble chambers. In thi...

  13. Igale inimesele oma inspektor? / Andre Nõmm

    Index Scriptorium Estoniae

    Nõmm, Andre

    2007-01-01

    Finantsinspektsiooni finantsjärelevalve divisjoni juhataja Andre Nõmm on seisukohal, et finantsinspektsiooni ülesanne ei ole valvata iga kodaniku finantsriski maandamist, vaid vastutust peab kandma iga inimene ise. Ometi on riigi eesmärk tõsta oma kodanike teadlikkust laenuturul valitsevatest ohtudest

  14. Eesti fond rahastab Vene infotehnoloogiat / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2006-01-01

    Martinson Trigon Venture Partners (MTVP) loob uue tarkvarainvesteeringute fondi, mis viib endise NSVL-i alale kuni 780 miljonit krooni, fond võtab sihiks kümmekond uut ettevõtet. MTVP esimese fondi investeeringutest. Fondide juhi Andres Susi selgitusi. Lisa: Martinson Trigon Venture Partners osalusega firmad; Vt. samas: Moskvas pole raha ja geeniused kohtunud

  15. PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.

    Directory of Open Access Journals (Sweden)

    Filip Janku

    Full Text Available Oncogenic mutations of PIK3CA, RAS (KRAS, NRAS, and BRAF have been identified in various malignancies, and activate the PI3K/AKT/mTOR and RAS/RAF/MEK pathways, respectively. Both pathways are critical drivers of tumorigenesis.Tumor tissues from 504 patients with diverse cancers referred to the Clinical Center for Targeted Therapy at MD Anderson Cancer Center starting in October 2008 were analyzed for PIK3CA, RAS (KRAS, NRAS, and BRAF mutations using polymerase chain reaction-based DNA sequencing.PIK3CA mutations were found in 54 (11% of 504 patients tested; KRAS in 69 (19% of 367; NRAS in 19 (8% of 225; and BRAF in 31 (9% of 361 patients. PIK3CA mutations were most frequent in squamous cervical (5/14, 36%, uterine (7/28, 25%, breast (6/29, 21%, and colorectal cancers (18/105, 17%; KRAS in pancreatic (5/9, 56%, colorectal (49/97, 51%, and uterine cancers (3/20, 15%; NRAS in melanoma (12/40, 30%, and uterine cancer (2/11, 18%; BRAF in melanoma (23/52, 44%, and colorectal cancer (5/88, 6%. Regardless of histology, KRAS mutations were found in 38% of patients with PIK3CA mutations compared to 16% of patients with wild-type (wtPIK3CA (p = 0.001. In total, RAS (KRAS, NRAS or BRAF mutations were found in 47% of patients with PIK3CA mutations vs. 24% of patients wtPIK3CA (p = 0.001. PIK3CA mutations were found in 28% of patients with KRAS mutations compared to 10% with wtKRAS (p = 0.001 and in 20% of patients with RAS (KRAS, NRAS or BRAF mutations compared to 8% with wtRAS (KRAS, NRAS or wtBRAF (p = 0.001.PIK3CA, RAS (KRAS, NRAS, and BRAF mutations are frequent in diverse tumors. In a wide variety of tumors, PIK3CA mutations coexist with RAS (KRAS, NRAS and BRAF mutations.

  16. MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA

    International Nuclear Information System (INIS)

    Lang, Qingbo; Ling, Changquan

    2012-01-01

    Highlights: ► PIK3CA is a novel target of miR-124 in HepG2 cells. ► MiR-124 suppresses cell proliferation by downregulating PIK3CA expression. ► MiR-124 regulates the PI3K/Akt pathway in HepG2 cells. ► MiR-124 overexpression inhibits the tumorigenesis in nude mice. -- Abstract: MicroRNAs (miRNAs) have crucial roles in the development and progression of human cancers, including hepatocellular carcinoma (HCC). Recent studies have shown that microRNA-124 (miR-124) was downregulated in HCC; however, the underlying mechanisms by which miR-124 suppresses tumorigenesis in HCC are largely unknown. In this study, we report that phosphoinositide 3-kinase catalytic subunit alpha (PIK3CA) is a novel target of miR-124 in HepG2 cells. Overexpression of miR-124 resulted in decreased expression of PIK3CA at both mRNA and protein levels. We found that miR-124 overexpression markedly suppressed cell proliferation by inducing G1-phase cell-cycle arrest in vitro. Consistent with the restoring miR-124 expression, PIK3CA knockdown suppressed cell proliferation, whereas overexpression of PIK3CA abolished the suppressive effect of miR-124. Mechanistic studies showed that miR-124-mediated reduction of PIK3CA resulted in suppression of PI3K/Akt pathway. The expressions of Akt and mTOR, key components of the PI3K/Akt pathway, were all downregulated. Moreover, we found overexpressed miR-124 effectively repressed tumor growth in xenograft animal experiments. Taken together, our results demonstrate that miR-124 functions as a growth-suppressive miRNA and plays an important role in inhibiting the tumorigenesis through targeting PIK3CA.

  17. p55PIK regulates alpha-fetoprotein expression through the NF-κB signaling pathway.

    Science.gov (United States)

    Ye, Guoguo; Sun, Ge; Cheng, Zhikui; Zhang, Lei; Hu, Kanghong; Xia, Xianmin; Zhou, Yin

    2017-12-15

    Alpha-fetoprotein (AFP) is regarded as a diagnostic and prognostic biomarker and a potential therapeutic target for hepatocellular carcinoma (HCC). However, the regulation of AFP expression in HCC remains poorly understood. This study aimed to investigate the mechanism by which AFP expression is regulated by p55PIK, an isoform of PI3K. Human HCC cell lines (HepG2 and Huh-7) were treated with p55PIK specific competitive inhibitor or shRNA, or p55PIK overexpression vector, in the absence or presence of NF-κB inhibitor PDTC. AFP expression was detected by quantitative real-time PCR and Western blotting. NF-κB responsive elements in AFP enhancer region were characterized by luciferase reporter assay. p55PIK significantly stimulated the expression of AFP by activating NF-κB signaling pathway in HCC cells. Furthermore, two NF-κB binding sites in AFP enhancer region were identified to be primarily responsible for p55PIK mediated upregulation of AFP expression. p55PIK/NF-κB signaling plays an important role in the upregulation of AFP expression in HCC. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Program for studying fundamental interactions at the PIK reactor facilities

    International Nuclear Information System (INIS)

    Serebrov, A. P.; Vassiljev, A. V.; Varlamov, V. E.; Geltenbort, P.; Gridnev, K. A.; Dmitriev, S. P.; Dovator, N. A.; Egorov, A. I.; Ezhov, V. F.; Zherebtsov, O. M.; Zinoviev, V. G.; Ivochkin, V. G.; Ivanov, S. N.; Ivanov, S. A.; Kolomensky, E. A.; Konoplev, K. A.; Krasnoschekova, I. A.; Lasakov, M. S.; Lyamkin, V. A.; Martemyanov, V. P.

    2016-01-01

    A research program aimed at studying fundamental interactions by means of ultracold and polarized cold neutrons at the GEK-4-4′ channel of the PIK reactor is presented. The apparatus to be used includes a source of cold neutrons in the heavy-water reflector of the reactor, a source of ultracold neutrons based on superfluid helium and installed in a cold-neutron beam extracted from the GEK-4 channel, and a number of experimental facilities in neutron beams. An experiment devoted to searches for the neutron electric dipole moment and an experiment aimed at a measurement the neutron lifetime with the aid of a large gravitational trap are planned to be performed in a beam of ultracold neutrons. An experiment devoted to measuring neutron-decay asymmetries with the aid of a superconducting solenoid is planned in a beam of cold polarized neutrons from the GEK-4′ channel. The second ultracold-neutron source and an experiment aimed at measuring the neutron lifetime with the aid of a magnetic trap are planned in the neutron-guide system of the GEK-3 channel. In the realms of neutrino physics, an experiment intended for sterile-neutrino searches is designed. The state of affairs around the preparation of the experimental equipment for this program is discussed.

  19. Program for studying fundamental interactions at the PIK reactor facilities

    Energy Technology Data Exchange (ETDEWEB)

    Serebrov, A. P., E-mail: serebrov@pnpi.spb.ru; Vassiljev, A. V.; Varlamov, V. E. [National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute (Russian Federation); Geltenbort, P. [Institut Laue-Langevin (France); Gridnev, K. A. [St. Petersburg State University (Russian Federation); Dmitriev, S. P.; Dovator, N. A. [Russian Academy of Sciences, Ioffe Physical-Technical Institute (Russian Federation); Egorov, A. I.; Ezhov, V. F.; Zherebtsov, O. M.; Zinoviev, V. G.; Ivochkin, V. G.; Ivanov, S. N.; Ivanov, S. A.; Kolomensky, E. A.; Konoplev, K. A.; Krasnoschekova, I. A.; Lasakov, M. S.; Lyamkin, V. A. [National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute (Russian Federation); Martemyanov, V. P. [National Research Center Kurchatov Institute (Russian Federation); and others

    2016-05-15

    A research program aimed at studying fundamental interactions by means of ultracold and polarized cold neutrons at the GEK-4-4′ channel of the PIK reactor is presented. The apparatus to be used includes a source of cold neutrons in the heavy-water reflector of the reactor, a source of ultracold neutrons based on superfluid helium and installed in a cold-neutron beam extracted from the GEK-4 channel, and a number of experimental facilities in neutron beams. An experiment devoted to searches for the neutron electric dipole moment and an experiment aimed at a measurement the neutron lifetime with the aid of a large gravitational trap are planned to be performed in a beam of ultracold neutrons. An experiment devoted to measuring neutron-decay asymmetries with the aid of a superconducting solenoid is planned in a beam of cold polarized neutrons from the GEK-4′ channel. The second ultracold-neutron source and an experiment aimed at measuring the neutron lifetime with the aid of a magnetic trap are planned in the neutron-guide system of the GEK-3 channel. In the realms of neutrino physics, an experiment intended for sterile-neutrino searches is designed. The state of affairs around the preparation of the experimental equipment for this program is discussed.

  20. Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

    Energy Technology Data Exchange (ETDEWEB)

    Murat, C.B.; Braga, P.B.S.; Fortes, M.A.H.Z. [Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Bronstein, M.D. [Unidade de Neuroendocrinologia, Serviço de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Corrêa-Giannella, M.L.C.; Giorgi, R.R. [Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

    2012-07-13

    The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting macroadenomas, and 15 nonfunctioning macroadenomas. Direct sequencing of exons 9 and 20 assessed by qPCR was employed to investigate the presence of mutations and genomic amplification defined as a copy number ≥4. Previously identified PIK3CA mutations (exon 20) were detected in four cases (12.1%). Interestingly, the Chinese study reported mutations only in invasive tumors, while we found a PIK3CA mutation in one noninvasive corticotroph microadenoma. PIK3CA amplification was observed in 21.2% (7/33) of the cases. This study demonstrates the presence of somatic mutations and amplifications of the PIK3CA gene in a second series of pituitary adenomas, corroborating the previously described involvement of the PI3K/Akt signaling pathway in the tumorigenic process of this gland.

  1. Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

    International Nuclear Information System (INIS)

    Murat, C.B.; Braga, P.B.S.; Fortes, M.A.H.Z.; Bronstein, M.D.; Corrêa-Giannella, M.L.C.; Giorgi, R.R.

    2012-01-01

    The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting macroadenomas, and 15 nonfunctioning macroadenomas. Direct sequencing of exons 9 and 20 assessed by qPCR was employed to investigate the presence of mutations and genomic amplification defined as a copy number ≥4. Previously identified PIK3CA mutations (exon 20) were detected in four cases (12.1%). Interestingly, the Chinese study reported mutations only in invasive tumors, while we found a PIK3CA mutation in one noninvasive corticotroph microadenoma. PIK3CA amplification was observed in 21.2% (7/33) of the cases. This study demonstrates the presence of somatic mutations and amplifications of the PIK3CA gene in a second series of pituitary adenomas, corroborating the previously described involvement of the PI3K/Akt signaling pathway in the tumorigenic process of this gland

  2. Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer.

    Directory of Open Access Journals (Sweden)

    Paolo Cossu-Rocca

    Full Text Available Triple Negative Breast Cancer (TNBC accounts for 12-24% of all breast carcinomas, and shows worse prognosis compared to other breast cancer subtypes. Molecular studies demonstrated that TNBCs are a heterogeneous group of tumors with different clinical and pathologic features, prognosis, genetic-molecular alterations and treatment responsivity. The PI3K/AKT is a major pathway involved in the regulation of cell survival and proliferation, and is the most frequently altered pathway in breast cancer, apparently with different biologic impact on specific cancer subtypes. The most common genetic abnormality is represented by PIK3CA gene activating mutations, with an overall frequency of 20-40%. The aims of our study were to investigate PIK3CA gene mutations on a large series of TNBC, to perform a wider analysis on genetic alterations involving PI3K/AKT and BRAF/RAS/MAPK pathways and to correlate the results with clinical-pathologic data.PIK3CA mutation analysis was performed by using cobas® PIK3CA Mutation Test. EGFR, AKT1, BRAF, and KRAS genes were analyzed by sequencing. Immunohistochemistry was carried out to identify PTEN loss and to investigate for PI3K/AKT pathways components.PIK3CA mutations were detected in 23.7% of TNBC, whereas no mutations were identified in EGFR, AKT1, BRAF, and KRAS genes. Moreover, we observed PTEN loss in 11.3% of tumors. Deregulation of PI3K/AKT pathways was revealed by consistent activation of pAKT and p-p44/42 MAPK in all PIK3CA mutated TNBC.Our data shows that PIK3CA mutations and PI3K/AKT pathway activation are common events in TNBC. A deeper investigation on specific TNBC genomic abnormalities might be helpful in order to select patients who would benefit from current targeted therapy strategies.

  3. Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer.

    Science.gov (United States)

    Cossu-Rocca, Paolo; Orrù, Sandra; Muroni, Maria Rosaria; Sanges, Francesca; Sotgiu, Giovanni; Ena, Sara; Pira, Giovanna; Murgia, Luciano; Manca, Alessandra; Uras, Maria Gabriela; Sarobba, Maria Giuseppina; Urru, Silvana; De Miglio, Maria Rosaria

    2015-01-01

    Triple Negative Breast Cancer (TNBC) accounts for 12-24% of all breast carcinomas, and shows worse prognosis compared to other breast cancer subtypes. Molecular studies demonstrated that TNBCs are a heterogeneous group of tumors with different clinical and pathologic features, prognosis, genetic-molecular alterations and treatment responsivity. The PI3K/AKT is a major pathway involved in the regulation of cell survival and proliferation, and is the most frequently altered pathway in breast cancer, apparently with different biologic impact on specific cancer subtypes. The most common genetic abnormality is represented by PIK3CA gene activating mutations, with an overall frequency of 20-40%. The aims of our study were to investigate PIK3CA gene mutations on a large series of TNBC, to perform a wider analysis on genetic alterations involving PI3K/AKT and BRAF/RAS/MAPK pathways and to correlate the results with clinical-pathologic data. PIK3CA mutation analysis was performed by using cobas® PIK3CA Mutation Test. EGFR, AKT1, BRAF, and KRAS genes were analyzed by sequencing. Immunohistochemistry was carried out to identify PTEN loss and to investigate for PI3K/AKT pathways components. PIK3CA mutations were detected in 23.7% of TNBC, whereas no mutations were identified in EGFR, AKT1, BRAF, and KRAS genes. Moreover, we observed PTEN loss in 11.3% of tumors. Deregulation of PI3K/AKT pathways was revealed by consistent activation of pAKT and p-p44/42 MAPK in all PIK3CA mutated TNBC. Our data shows that PIK3CA mutations and PI3K/AKT pathway activation are common events in TNBC. A deeper investigation on specific TNBC genomic abnormalities might be helpful in order to select patients who would benefit from current targeted therapy strategies.

  4. The Capsicum annuum class IV chitinase ChitIV interacts with receptor-like cytoplasmic protein kinase PIK1 to accelerate PIK1-triggered cell death and defence responses

    Science.gov (United States)

    Kim, Dae Sung; Kim, Nak Hyun; Hwang, Byung Kook

    2015-01-01

    The pepper receptor-like cytoplasmic protein kinase, CaPIK1, which mediates signalling of plant cell death and defence responses was previously identified. Here, the identification of a class IV chitinase, CaChitIV, from pepper plants (Capsicum annuum), which interacts with CaPIK1 and promotes CaPIK1-triggered cell death and defence responses, is reported. CaChitIV contains a signal peptide, chitin-binding domain, and glycol hydrolase domain. CaChitIV expression was up-regulated by Xanthomonas campestris pv. vesicatoria (Xcv) infection. Notably, avirulent Xcv infection rapidly induced CaChitIV expression in pepper leaves. Bimolecular fluorescence complementation and co-immunoprecipitation revealed that CaPIK1 interacts with CaChitIV in planta, and that the CaPIK1–CaChitIV complex is localized mainly in the cytoplasm and plasma membrane. CaChitIV is also localized in the endoplasmic reticulum. Transient co-expression of CaChitIV with CaPIK1 enhanced CaPIK1-triggered cell death response and reactive oxygen species (ROS) and nitric oxide (NO) bursts. Co-silencing of both CaChitIV and CaPIK1 in pepper plants conferred enhanced susceptibility to Xcv infection, which was accompanied by a reduced induction of cell death response, ROS and NO bursts, and defence response genes. Ectopic expression of CaPIK1 in Arabidopsis enhanced basal resistance to Hyaloperonospora arabidopsidis infection. Together, the results suggest that CaChitIV positively regulates CaPIK1-triggered cell death and defence responses through its interaction with CaPIK1. PMID:25694549

  5. Étude de la toxicité des extraits foliaires d’Euphorbia guyoniana Boiss. et Reut. (Euphorbiaceae chez Schistocerca gregaria (Forskål, 1775 (Orthoptera-Acrididea

    Directory of Open Access Journals (Sweden)

    A. KEMASSI

    2013-03-01

    Full Text Available Study of the toxicity of the crude acetone leaf extract of Euphorbia guyoniana Boiss. and Reut. (Euphorbiaceae in Schistocerca gregaria (Forskål, 1775 (Orthoptera-Acrididea Abstract-This study examines the effect by ingestion of leaf cabbage sprayed with crude acetone extract of Euphorbia guyoniana leaves harvested in the Algerian Sahara on some biological parameters of larvae L5 and adult of desert locusts. The ingestion of cabbage leaves soaked in acetone extract of this Saharan plant generates a 100% mortality in larvae L5 and 66,67% for adult. A significant reduction in food intake was observed in the treated population compared to the control population. It results in a loss of exceptional weight ranging from 26,93% in larvae L5 to 33,09% in adults. Difficulties and anomalies are observed in moulting 16,66% of larvae L5 fed with cabbage leaves soaked in leaf extract of E. guyoniana. Dissection of adult females of the lot processing allows the observation of body regression demonstrating the depressant action of this extract on ovocyte cycle in the desert locust.

  6. FGFR3, PIK3CA and RAS mutations in benign lichenoid keratosis.

    Science.gov (United States)

    Groesser, L; Herschberger, E; Landthaler, M; Hafner, C

    2012-04-01

    Benign lichenoid keratoses (BLKs) are solitary skin lesions which have been proposed to represent a regressive form of pre-existent epidermal tumours such as solar lentigo or seborrhoeic keratosis. However, the genetic basis of BLK is unknown. FGFR3, PIK3CA and RAS mutations have been shown to be involved in the pathogenesis of seborrhoeic keratosis and solar lentigo. We thus investigated whether these mutations are also present in BLK. After manual microdissection and DNA isolation, 52 BLKs were screened for FGFR3, PIK3CA and RAS hotspot mutations using SNaPshot(®) multiplex assays. We identified 6/52 (12%) FGFR3 mutations, 10/52 (19%) PIK3CA mutations, 6/52 (12%) HRAS mutations and 2/52 (4%) KRAS mutations. FGFR3 and RAS mutations were mutually exclusive. One BLK showed a simultaneous PIK3CA and HRAS mutation. In nine BLKs with a mutation, nonlesional control tissue from the epidermal margin and the dermal lymphocytic infiltrate were wild-type, indicating that these mutations are somatic. To demonstrate that these findings are specific, 10 samples of lichen planus were analysed without evidence for FGFR3, PIK3CA or RAS mutations. Our results indicate that FGFR3, PIK3CA and RAS mutations are present in approximately 50% of BLKs. These findings support the concept on the molecular genetic level that at least a proportion of BLKs represents regressive variants resulting from former benign epidermal tumours such as seborrhoeic keratosis and solar lentigo. © 2011 The Authors. BJD © 2011 British Association of Dermatologists 2011.

  7. Andres Võsand: hakkan ilmselt elukutseliseks kunstnikuks / Andres Võsand ; intervjueerinud Veiko Visnapuu

    Index Scriptorium Estoniae

    Võsand, Andres, 1966-

    2010-01-01

    Intervjuu Saksaamaal elava tennisisti Andres Võsandiga, kelle maalinäitus "Värvireisid" on avatud Kadriorus Kastellaanimaja Galeriis 30.10-28.11.2010. Tegelemisest maalikunstiga, näitusest, reisidest inspireeritud loomingust, tööst tennisetreenerina, tennisekarjäärist. Andmeid A. Võsandi elukäigu kohta

  8. Tumor PIK3CA genotype and prognosis in early-stage breast cancer

    DEFF Research Database (Denmark)

    Zardavas, Dimitrios; Te Marvelde, Luc; Milne, Roger L.

    2018-01-01

    % in the ER-negative/HER2-negative, HER2-positive, and ER-positive/HER2-negative subtypes, respectively. In univariable analysis, PIK3CA mutations were associated with better IDFS (HR, 0.77; 95% CI, 0.71 to 0.84; P, .001), with evidence for a stronger effect in the first years of follow-up (0 to 5 years: HR...... points. Conclusion In this large pooled analysis, PIK3CA mutations were significantly associated with a better IDFS, DDFS, and OS, but had a lesser prognostic effect after adjustment for other prognostic factors....

  9. MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA

    Energy Technology Data Exchange (ETDEWEB)

    Lang, Qingbo [Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433 (China); Ling, Changquan, E-mail: lingchangquan@hotmail.com [Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433 (China)

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer PIK3CA is a novel target of miR-124 in HepG2 cells. Black-Right-Pointing-Pointer MiR-124 suppresses cell proliferation by downregulating PIK3CA expression. Black-Right-Pointing-Pointer MiR-124 regulates the PI3K/Akt pathway in HepG2 cells. Black-Right-Pointing-Pointer MiR-124 overexpression inhibits the tumorigenesis in nude mice. -- Abstract: MicroRNAs (miRNAs) have crucial roles in the development and progression of human cancers, including hepatocellular carcinoma (HCC). Recent studies have shown that microRNA-124 (miR-124) was downregulated in HCC; however, the underlying mechanisms by which miR-124 suppresses tumorigenesis in HCC are largely unknown. In this study, we report that phosphoinositide 3-kinase catalytic subunit alpha (PIK3CA) is a novel target of miR-124 in HepG2 cells. Overexpression of miR-124 resulted in decreased expression of PIK3CA at both mRNA and protein levels. We found that miR-124 overexpression markedly suppressed cell proliferation by inducing G1-phase cell-cycle arrest in vitro. Consistent with the restoring miR-124 expression, PIK3CA knockdown suppressed cell proliferation, whereas overexpression of PIK3CA abolished the suppressive effect of miR-124. Mechanistic studies showed that miR-124-mediated reduction of PIK3CA resulted in suppression of PI3K/Akt pathway. The expressions of Akt and mTOR, key components of the PI3K/Akt pathway, were all downregulated. Moreover, we found overexpressed miR-124 effectively repressed tumor growth in xenograft animal experiments. Taken together, our results demonstrate that miR-124 functions as a growth-suppressive miRNA and plays an important role in inhibiting the tumorigenesis through targeting PIK3CA.

  10. PIK3CA expression in diffuse large B cell lymphoma tissue and the effect of its knockdown in vitro

    Directory of Open Access Journals (Sweden)

    Cui W

    2017-04-01

    Full Text Available Wenli Cui,1–4,* Shutao Zheng,5,6,* Zebing Liu,1–3 Weige Wang,1–3 Ying Cai,1–3 Rui Bi,1–3 Bing Cao,1–3 Xiaoyan Zhou1–3 1Department of Pathology, Shanghai Cancer Center, Fudan University, 2Department of Oncology, Shanghai Medical College, Fudan University, 3Institute of Pathology, Fudan University, Shanghai, 4Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, 5Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, 6State Key Lab Incubation Base of Xinjiang Major Diseases Research, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, People’s Republic of China *These authors contributed equally to this work Abstract: PIK3CA has been extensively investigated from its molecular mechanism perspective and epidemiological association with its mutations in different types of cancers. However, little has been reported regarding the clinicopathological significance of PIK3CA expression in diffuse large B cell lymphoma (DLBCL. In the present study, we investigated the clinicopathological significance of PIK3CA in DLBCL by performing immunohistochemical evaluation of PIK3CA in tissue microarrays consisting of 199 cases of DLBCL. Kaplan–Meier survival analysis was performed to analyze the association between PIK3CA expression and overall prognosis. To further investigate the role of PIK3CA mediated in the proliferation, cell cycle and apoptosis of DLBCL cells, Cell Counting Kit-8 (CCK-8 and flow cytometry assays were carried out in DLBCL cell lines after successful, stable knockdown of PIK3CA using lentiviral short hairpin RNA inference. Our results indicated that although PIK3CA was shown to be extensively expressed in DLBCL, no significant association was observed between PIK3CA expression and clinical outcome or between PIK3CA expression and other clinicopathological parameters, except between performance state (PS

  11. PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma

    International Nuclear Information System (INIS)

    Chiosea, Simion I; Nikiforova, Marina N; Grandis, Jennifer R; Lui, Vivian W Y; Diergaarde, Brenda; Maxwell, Jessica H; Ferris, Robert L; Kim, Seungwon W; Luvison, Alyssa; Miller, Megan

    2013-01-01

    Recent genomic evidence suggests frequent phosphatidylinositide 3-kinase (PI3K) pathway activation in human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. Mutations/amplification of the gene encoding p110α catalytic subunit of phosphoinositide 3-kinase (PIK3CA), loss of phosphatase and tensin homolog (PTEN) and HRAS mutations are known to activate PI3K pathway. PIK3CA mutations were identified by Sanger sequencing in 23 of 75 (31%) HPV-positive oropharyngeal carcinomas, including exon 9 (p.E545K [n = 10] and p.E542K [n = 5]) or exon 20 (p.H1047Y, n = 2) mutations. Five rare and one novel (p.R537Q) PIK3CA mutations were identified. HRAS mutation (p.Q61L) was detected in 1 of 62 tested cases. PIK3CA amplification by fluorescence in situ hybridization (FISH) was identified in 4 cases (4/21, 20%), while PTEN loss was seen in 7 (7/21, 33%) cases (chromosome 10 monosomy [n = 4], homozygous deletion [n = 3]). Overall, genetic alterations that likely lead to PI3K pathway activation were identified in 34 of 75 cases (45%) and did not correlate with disease specific survival. These findings offer a molecular rationale for therapeutic targeting of PI3K pathway in patients with HPV-positive oropharyngeal carcinoma

  12. Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

    Directory of Open Access Journals (Sweden)

    Shun Liang

    Full Text Available The Phosphatidylinositol 3'-kinase is a key regulator in various cancer-associated signal transduction pathways. Genetic alterations of its catalytic subunit alpha, PIK3CA, have been identified in ovarian cancer. Our in vivo data suggests that PIK3CA activation is one of the early genetic events in ovarian cancer. However, its role in malignant transformation of ovarian surface epithelium (OSE is largely unclear.Using the Müllerian inhibiting substance type II receptor (MISIIR promoter, we generated transgenic mice that expressed activated PIK3CA in the Müllerian epithelium. Overexpression of PIK3CA in OSE induced remarkable hyperplasia, but was not able to malignantly transform OSE in vivo. The consistent result was also observed in primary cultured OSEs. Although enforced expression of PIK3CA could not induce OSE anchorage-independent growth, it significantly increased anchorage-independent growth of OSE transformed by mutant K-ras.While PIK3CA activation may not be able to initiate OSE transformation, we conclude that activation of PIK3CA may be an important molecular event contributing to the maintenance of OSE transformation initiated by oncogenes such as K-ras.

  13. MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yihui [Department of Colorectal Surgery, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Road, 150081 Harbin (China); Tang, Qingchao [Cancer Center, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086 Harbin (China); Li, Mingqi; Jiang, Shixiong [Department of Colorectal Surgery, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Road, 150081 Harbin (China); Wang, Xishan, E-mail: wxshan12081@163.com [Cancer Center, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086 Harbin (China)

    2014-02-07

    Highlights: • miR-375 is downregulated in colorectal cancer cell lines and tissues. • miR-375 inhibits colorectal cancer cell growth by targeting PIK3CA. • miR-375 inhibits colorectal cancer cell growth in xenograft nude mice model. - Abstract: Colorectal cancer (CRC) is the second most common cause of death from cancer. MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by triggering RNA degradation or interfering with translation. Aberrant miRNA expression is involved in human disease including cancer. Herein, we showed that miR-375 was frequently down-regulated in human colorectal cancer cell lines and tissues when compared to normal human colon tissues. PIK3CA was identified as a potential miR-375 target by bioinformatics. Overexpression of miR-375 in SW480 and HCT15 cells reduced PIK3CA protein expression. Subsequently, using reporter constructs, we showed that the PIK3CA untranslated region (3′-UTR) carries the directly binding site of miR-375. Additionally, miR-375 suppressed CRC cell proliferation and colony formation and led to cell cycle arrest. Furthermore, miR-375 overexpression resulted in inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. SiRNA-mediated silencing of PIK3CA blocked the inhibitory effect of miR-375 on CRC cell growth. Lastly, we found overexpressed miR-375 effectively repressed tumor growth in xenograft animal experiments. Taken together, we propose that overexpression of miR-375 may provide a selective growth inhibition for CRC cells by targeting PI3K/Akt signaling pathway.

  14. Andrés Rivera, Escritor social

    Directory of Open Access Journals (Sweden)

    Marta Waldegaray

    2006-07-01

    Full Text Available La narrativa de Andrés Rivera hace de la historia el material de origen de la escritura y de su convicción política de izquierda el molde en el cual desde hace ya más de cuatro décadas su escritura adquiere forma.Acontecimiento histórico, circunstancia política, poseen en sus primeras novelas el valor de verdad política, de testimonio social. La convicción ideológica que sus libros exhiben se acompaña de una trayectoria literaria que, en su práctica inicial, fue confiada a la representación r...

  15. Eesti Energia esindused = Eesti Energia branches / Andres Labi, Janno Roos

    Index Scriptorium Estoniae

    Labi, Andres, 1977-

    2013-01-01

    Eesti Energia klienditeeninduse kontorite sisekujundusest. Autorid: Janno Roos, Andres Labi ja Liisa Põime (Ruumilabor). Visuaalne identiteet: Tank.Teenuste disain: Urmas Pastarus. ESLi aastapreemiate žürii esimehe Kaido Kivi ning žürii liikme Raivo Puusepa arvamused

  16. Jumalaema kiriku kellamees tuli Tartu Toome varemetesse / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    13. juulil esietendus Emajõe Suveteatris "Jumalaema kiriku kellamees". Victor Hugo romaani järgi tegi instseneeringu Urmas Lennuk, lavastaja Andres Dvinjaninov. Mängitakse Tartu Toomkiriku varemetes

  17. "Vettpidavad allikad" = "Watertight sources" / Janno Roos, Andres Labi

    Index Scriptorium Estoniae

    Roos, Janno, 1976-

    2013-01-01

    Eesti Ajaloomuuseumis avatud näituse kujundasid Janno Roos ja Andres Labi (Ruumilabor). Kuraator Krista Sarv. Graafiline disain: Identity. Eksponeeritud allveeuuringute käigus leitu. Arhitektuuriajaloolase Leele Välja arvamus

  18. Andres Tolts 60 : omanäoliste vaikelude imeline maailm / Andres Tolts ; intervjueerinud Tiina Kolk ; kommenteerinud Jaan Elken

    Index Scriptorium Estoniae

    Tolts, Andres, 1949-2014

    2009-01-01

    Andres Toltsi näitused "Asjad" Hobusepea galeriis 12. oktoobrini, "Näitus" Tallinna Kunstihoones 25. oktoobrini, "Varane Tolts" Haus galeriis 13. novembrini. Pikemalt näitusest "Näitus", kuraator Harry Liivrand

  19. An integrative genomic and proteomic analysis of PIK3CA, PTEN and AKT mutations in breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Stemke-Hale, Katherine; Gonzalez-Angulo, Ana Maria; Lluch, Ana; Neve, Richard M.; Kuo, Wen-Lin; Davies, Michael; Carey, Mark; Hu, Zhi; Guan, Yinghui; Sahin, Aysegul; Symmans, W. Fraser; Pusztai, Lajos; Nolden, Laura K.; Horlings, Hugo; Berns, Katrien; Hung, Mien-Chie; van de Vijver, Marc J.; Valero, Vicente; Gray, Joe W.; Bernards, Rene; Mills, Gordon B.; Hennessy, Bryan T.

    2008-05-06

    Phosphatidylinositol-3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT and PTEN mutations, and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in-vitro and on outcome after adjuvant tamoxifen. PIK3CA mutations were more common in hormone receptor positive (33.8%) and HER2-positive (24.6%) than in basal-like tumors (8.3%). AKT1 (1.4%) and PTEN (2.3%) mutations were restricted to hormone receptor-positive cancers with PTEN protein levels also being significantly lower in hormone receptor-positive cancers. Unlike AKT1 mutations, PIK3CA (39%) and PTEN (20%) mutations were more common in cell lines than tumors, suggesting a selection for these but not AKT1 mutations during adaptation to culture. PIK3CA mutations did not have a significant impact on outcome in 166 hormone receptor-positive breast cancer patients after adjuvant tamoxifen. PIK3CA mutations, in comparison with PTEN loss and AKT1 mutations, were associated with significantly less and indeed inconsistent activation of AKT and of downstream PI3K/AKT signaling in tumors and cell lines, and PTEN loss and PIK3CA mutation were frequently concordant, suggesting different contributions to pathophysiology. PTEN loss but not PIK3CA mutations rendered cells sensitive to growth inhibition by the PI3K inhibitor LY294002. Thus, PI3K pathway aberrations likely play a distinct role in the pathogenesis of different breast cancer subtypes. The specific aberration may have implications for the selection of PI3K-targeted therapies in hormone receptor-positive breast cancer.

  20. Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway.

    Science.gov (United States)

    Lou, Hong; Villagran, Guillermo; Boland, Joseph F; Im, Kate M; Polo, Sarita; Zhou, Weiyin; Odey, Ushie; Juárez-Torres, Eligia; Medina-Martínez, Ingrid; Roman-Basaure, Edgar; Mitchell, Jason; Roberson, David; Sawitzke, Julie; Garland, Lisa; Rodríguez-Herrera, Maria; Wells, David; Troyer, Jennifer; Pinto, Francisco Castillo; Bass, Sara; Zhang, Xijun; Castillo, Miriam; Gold, Bert; Morales, Hesler; Yeager, Meredith; Berumen, Jaime; Alvirez, Enrique; Gharzouzi, Eduardo; Dean, Michael

    2015-12-01

    Cervical cancer is one of the most common causes of cancer mortality for women living in poverty, causing more than 28,000 deaths annually in Latin America and 266,000 worldwide. To better understand the molecular basis of the disease, we ascertained blood and tumor samples from Guatemala and Venezuela and performed genomic characterization. We performed human papillomavirus (HPV) typing and identified somatically mutated genes using exome and ultra-deep targeted sequencing with confirmation in samples from Mexico. Copy number changes were also assessed in the exome sequence. Cervical cancer cases in Guatemala and Venezuela have an average age of diagnosis of 50 years and 5.6 children. Analysis of 675 tumors revealed activation of PIK3CA and other PI3K/AKT pathway genes in 31% of squamous carcinomas and 24% of adeno- and adenosquamous tumors, predominantly at two sites (E542K, E545K) in the helical domain of the PIK3CA gene. This distribution of PIK3CA mutations is distinct from most other cancer types and does not result in the in vitro phosphorylation of AKT. Somatic mutations were more frequent in squamous carcinomas diagnosed after the age of 50 years. Frequent gain of chromosome 3q was found, and low PIK3CA mutation fractions in many tumors suggest that PI3K mutation can be a late event in tumor progression. PI3K pathway mutation is important to cervical carcinogenesis in Latin America. Therapeutic agents that directly target PI3K could play a role in the therapy of this common malignancy. ©2015 American Association for Cancer Research.

  1. CLOVES syndrome: review of a PIK3CA-related overgrowth spectrum (PROS).

    Science.gov (United States)

    Martinez-Lopez, A; Blasco-Morente, G; Perez-Lopez, I; Herrera-Garcia, J D; Luque-Valenzuela, M; Sanchez-Cano, D; Lopez-Gutierrez, J C; Ruiz-Villaverde, R; Tercedor-Sanchez, J

    2017-01-01

    Overgrowth syndromes are characterized by global or localized disproportionate growth associated with other anomalies, including vascular malformations and neurological and/or visceral disorders. CLOVES (Congenital Lipomatous asymmetric Overgrowth of the trunk with lymphatic, capillary, venous, and combined-type Vascular malformations, Epidermal naevi, Scoliosis/Skeletal and spinal anomalies) is an overgrowth syndrome caused by mosaic activating mutation in gene PIK3CA, which gives rise to abnormal PI3K-AKT-mTOR pathway activation. These mutations are responsible for the clinical manifestations of the syndrome, which include low- and high-flow vascular malformations, thoracic lipomatous hyperplasia, asymmetric growth, and visceral and neurological disorders. These common anomalies are illustrated with figures from two personal cases. Identification of the clinical and genetic characteristics of CLOVES syndrome is crucial for the differential diagnosis with other overgrowth syndromes, such as Proteus or Klippel-Trenaunay (K-T) syndromes, and for the therapeutic management of the different anomalies. In this context, a new entity comprising different syndromes with phenotypic mutations in PIK3CA has been proposed, designated PIK3CA-related overgrowth spectrum (PROS), with the aim of facilitating clinical management and establishing appropriate genetic study criteria. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  2. Mutant PIK3CA Induces EMT in a Cell Type Specific Manner.

    Directory of Open Access Journals (Sweden)

    Divya Bhagirath

    Full Text Available Breast cancer is characterized into different molecular subtypes, and each subtype is characterized by differential gene expression that are associated with distinct survival outcomes in patients. PIK3CA mutations are commonly associated with most breast cancer subtypes. More recently PIK3CA mutations have been shown to induce tumor heterogeneity and are associated with activation of EGFR-signaling and reduced relapse free survival in basal subtype of breast cancer. Thus, understanding what determines PIK3CA induced heterogeneity and oncogenesis, is an important area of investigation. In this study, we assessed the effect of mutant PIK3CA together with mutant Ras plus mutant p53 on oncogenic behavior of two distinct stem/progenitor breast cell lines, designated as K5+/K19- and K5+/K19+. Constructs were ectopically overexpressed in K5+/K19- and K5+/K19+ stem/progenitor cells, followed by various in-vitro and in-vivo analyses. Oncogene combination m-Ras/m-p53/m-PIK3CA efficiently transformed both K5+/K19- and K5+/K19+ cell lines in-vitro, as assessed by anchorage-independent soft agar colony formation assay. Significantly, while this oncogene combination induced a complete epithelial-to-mesenchymal transition (EMT in K5+/K19- cell line, mostly epithelial phenotype with minor EMT component was seen in K5+/K19+ cell line. However, both K5+/K19- and K5+/K19+ transformed cells exhibited increased invasion and migration abilities. Analyses of CD44 and CD24 expression showed both cell lines had tumor-initiating CD44+/CD24low cell population, however transformed K5+/K19- cells had more proportion of these cells. Significantly, both cell types exhibited in-vivo tumorigenesis, and maintained their EMT and epithelial nature in-vivo in mice tumors. Notably, while both cell types exhibited increase in tumor-initiating cell population, differential EMT phenotype was observed in these cell lines. These results suggest that EMT is a cell type dependent

  3. Andres Tali sõnavõtt ettekannete päeval = Andres Tali's speech given on the lecture day / Andres Tali

    Index Scriptorium Estoniae

    Tali, Andres, 1956-

    2006-01-01

    Kaasaegse Kunsti Eesti Keskuse ettekannete päev "Kunstnike moraalsed valikud kultuurikonfliktides" 27.04.2006 Tallinna Kunstihoones. Oma installatsioonist "Pastoraalne pastishsh" ning videost "Vägivald ja propaganda - The Movie" samas 8.04.-28.05.2006 avatud Elin Kardi, Marko Mäetamme, Marco Laimre ja Andres Tali ühisnäitusel "Vägivald ja propaganda"

  4. Vi har uddelegeret forbruget og nydelsen til Netflix og de andre teknologigiganter

    DEFF Research Database (Denmark)

    Bak Herrie, Maja

    2018-01-01

    https://www.information.dk/debat/2018/05/uddelegeret-forbruget-nydelsen-netflix-andre-teknologigiganter......https://www.information.dk/debat/2018/05/uddelegeret-forbruget-nydelsen-netflix-andre-teknologigiganter...

  5. Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors

    Directory of Open Access Journals (Sweden)

    Filip Janku

    2014-01-01

    Full Text Available Despite a wealth of preclinical studies, it is unclear whether PIK3CA or phosphatase and tensin homolog (PTEN gene aberrations are actionable in the clinical setting. Of 1,656 patients with advanced, refractory cancers tested for PIK3CA or PTEN abnormalities, PIK3CA mutations were found in 9% (146/1,589, and PTEN loss and/or mutation was found in 13% (149/1,157. In multicovariable analysis, treatment with a phosphatidylinositol 3-kinase (PI3K/AKT/mammalian target of rapamycin (mTOR inhibitor was the only independent factor predicting response to therapy in individuals harboring a PIK3CA or PTEN aberration. The rate of stable disease ≥6 months/partial response reached 45% in a subgroup of individuals with H1047R PIK3CA mutations. Aberrations in the PI3K/AKT/mTOR pathway are common and potentially actionable in patients with diverse advanced cancers. This work provides further important clinical validation for continued and accelerated use of biomarker-driven trials incorporating rational drug combinations.

  6. UCN sources at external beams of thermal neutrons. An example of PIK reactor

    International Nuclear Information System (INIS)

    Lychagin, E.V.; Mityukhlyaev, V.A.; Muzychka, A.Yu.; Nekhaev, G.V.; Nesvizhevsky, V.V.; Onegin, M.S.; Sharapov, E.I.; Strelkov, A.V.

    2016-01-01

    We consider ultracold neutron (UCN) sources based on a new method of UCN production in superfluid helium ("4He). The PIK reactor is chosen as a perspective example of application of this idea, which consists of installing "4He UCN source in the beam of thermal or cold neutrons and surrounding the source with moderator-reflector, which plays the role of cold neutron (CN) source feeding the UCN source. CN flux in the source can be several times larger than the incident flux, due to multiple neutron reflections from the moderator–reflector. We show that such a source at the PIK reactor would provide an order of magnitude larger density and production rate than an analogous source at the ILL reactor. We estimate parameters of "4He source with solid methane (CH_4) or/and liquid deuterium (D_2) moderator–reflector. We show that such a source with CH_4 moderator–reflector at the PIK reactor would provide the UCN density of ~1·10"5 cm"−"3, and the UCN production rate of ~2·10"7 s"−"1. These values are respectively 1000 and 20 times larger than those for the most intense UCN user source. The UCN density in a source with D_2 moderator-reflector would reach the value of ~2·10"5 cm"−"3, and the UCN production rate would be equal ~8·10"7 s"−"1. Installation of such a source in a beam of CNs would slightly increase the density and production rate.

  7. Two design aspects connected with the safety of the PIK reactor presently under construction

    International Nuclear Information System (INIS)

    Gostev, V.V.; Zakharov, A.S.; Konoplev, K.A.; Levandovskii, N.V.; Ploshchanskii, L.M.; Smolsky, S.L.

    1993-01-01

    The PIK reactor is designed for physical research with neutron beams and sample irradiation. In the central trap the thermal neutrons flux is 4x10 15 n/cm 2 s. The reactor power is 100 MW, the thermal neutron flux in the reflector at the maximum of distribution is 1x10 15 n/cm 2 s. The core with a high uranium concentration of 600 g/l is light water-cooled, heavy water being used in the reflector. The Chernobyl disaster happened at the time of equipment installation at the PIK. The code revision, a change of the authors ideas about the safety, and a change of public attitude towards nuclear installations resulted in a stopping of construction and project revision. Reconstruction project has led to a change of all safety systems and involved in various degrees all essential reactor systems. The construction is presently resumed in spite of economic difficulties in Russia. The reactor was inspected by experts from a number of European countries, USA, and European Commission delegated by their governments to prepare a report on whether supporting the construction to its completion would be reasonable. In the course of inspection the experts from USA and EU expressed doubts concerning two systems, namely, the containment and scram. These two points are discussed in the present paper. Three type of containments are proposed and an analysis of their efficiency is presented. The PIK reactor is controlled by eight rods in the heavy-water reflector -and an absorbing cylinder at the boundary between the core and the central light-water neutron trap. The rods are used for emergency protection and reactor start-up. The central control cylinder called here the shutter serves several functions, namely, as scram, automatic control, and burnup compensation. The delay time before the onset of negative reactivity is 1.05 sec for rods and 0.25 sec for the shutter

  8. Les mots du jazz. Retour(s) sur Le Jazz, d'André Schaeffner et André Coeuroy

    OpenAIRE

    Roueff , Olivier

    2001-01-01

    International audience; Le Jazz by André Schaeffner and André Cœuroy (1926), the first learned analysis of jazz, signaled an important phase in the reinvention of this music in France, since, through the debates it sparked at the time, it helped change jazz’s identity from an « American » to a « Black American » music with African « roots ». Cœuroy and Schaeffner referred to sorts of music that jazz criticism would have throw out of its pantheon, but their analyses would form the major grids ...

  9. Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)

    International Nuclear Information System (INIS)

    Ji, Meiju; Guan, Haixia; Gao, Cuixia; Shi, Bingyin; Hou, Peng

    2011-01-01

    Lung cancer is the leading cause of cancer-related death worldwide. Genetic and epigenetic alterations have been identified frequently in lung cancer, such as promoter methylation, gene mutations and genomic amplification. However, the interaction between genetic and epigenetic events and their significance in lung tumorigenesis remains poorly understood. We determined the promoter methylation of 6 genes and PIK3CA amplification using quantitative methylation-specific PCR (Q-MSP) and real-time quantitative PCR, respectively, and explore the association of promoter methylation with PIK3CA amplification in a large cohort of clinically well-characterized non-small cell lung cancer (NSCLC). Highly frequent promoter methylation was observed in NSCLC. With 100% diagnostic specificity, excellent sensitivity, ranging from 45.8 to 84.1%, was found for each of the 6 genes. The promoter methylation was associated with histologic type. Methylation of CALCA, CDH1, DAPK1, and EVX2 was more common in squamous cell carcinomas (SCC) compared to adenocarcinomas (ADC). Conversely, there was a trend toward a higher frequency of RASSF1A methylation in ADC than SCC. In addition, PIK3CA amplification was frequently found in NSCLC, and was associated with certain clinicopathologic features, such as smoking history, histologic type and pleural indentation. Importantly, aberrant promoter methylation of certain genes was significantly associated with PIK3CA amplification. Our data showed highly frequent promoter methylation and PIK3CA amplification in Chinese NSCLC population, and first demonstrated the associations of gene methylation with PIK3CA amplification, suggesting that these epigenetic events may be a consequence of overactivation of PI3K/Akt pathway

  10. Mis siis juhtus Andres Lapeteusega? / Õie Orav

    Index Scriptorium Estoniae

    Orav, Õie

    2011-01-01

    Režissöör Grigori Kromanovi filmist "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1965). Osades: Einari Koppel, Ita Ever, Heino Mandri, Kaljo Kiisk, Uno Loit, Ada Lundver jt. Lühidalt filmi kohta ilmunud arvustustest. Filmi näeb ETV2-s sarjas "Unustatud filmid"

  11. Peaosa nii teatrilaval kui ka kinolinal / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    Natalja Murina-Puustusmaast, kes mängib peaosa Vene Teatri uuslavastuses "Besame mucho", mille Afolf Käis on lavastanud Eduardo de Filippo näidendi "Silinder" järgi, ja Andres Puustusmaa filmis "Rotilõks", mille võtted algavad peagi

  12. Kino, Theater, Fernsehen : André Bazins Publikumstheorie

    NARCIS (Netherlands)

    Hanich, Julian; Mundhenke, Florian; Weber, Thomas

    2017-01-01

    What did the great French film theorist André Bazin think of the collective experience in the cinema? What did he write about the influence co-viewers can have on the emotional engagement, the evaluation and the interpretation of a film? In short: What was his audience theory? To be sure, Bazin is

  13. Parts harvendas ootamatult Eesti Energia nõukogu / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2011-01-01

    Majandus- ja kommunikatsiooniminister Juhan Parts otsustas 1. juulil päevapealt Eesti Energia nõukogu liikme kohalt tagasi kutsuda Aivar Reiviku ning Rein Kuusmiku, kes olid vastu Eesti Energia üle viie miljoni euro suurusele investeeringule Weroli rapsiõlitehase juurde rajatavasse elektri- ja küttejaama. Uuteks nõukogu liikmeteks said Andres Saame ja Toomas Tauts

  14. Mis on looming.org? : elektrooniline heli / Andres Lõo

    Index Scriptorium Estoniae

    Lõo, Andres

    2004-01-01

    Võrguajakirjast www.looming.org, kuhu kogutakse infot põhiliselt kahe jaotuse põhjal: muusika ja helieksperimentalism ning kaasaegne kunst, kunsti ja meediaga seonduv. Idee autorid: Hanno Soans ja Andres Lõo. Ilmunud on looming.orgi esimene muusikakogumik "Lilled algebrale"

  15. 2623-IJBCS-Article-Gadji Alahou André

    African Journals Online (AJOL)

    hp

    1. Alahou André Gabazé GADJI1,2*, Ossey Bernard YAPO1, Kouabenan ABO2,. Ladji MEITE1, Agnès Eude Yves GNAGNE1, Satinder Kaur BRAR 3 et. Rajeshwar Dayal TYAGI4. 1Laboratoire des Sciences de l'Environnement (LSE), Unité de ...

  16. Andres Sütevaka näitus Stockholmis

    Index Scriptorium Estoniae

    2000-01-01

    Sütevaka Andrese abstraktsete maalide näitus Stockholmi Eesti Majas. Sütevaka Andres ja näituse avamisele sõitnud tema loomingu kollektsionäär Matti Milius kohtusid Moderna Museeti direktori David Elliotiga teadvustamaks Tartu ja Pärnu kunstielu.

  17. André François Boshoff

    African Journals Online (AJOL)

    Campbell Murn

    1945-2016) and pay tribute to him. An only child, André spent most of his childhood in very remote areas of southern Africa due to his magistrate father's various postings. Such locations, for example coastal. Transkei and the Caprivi Strip, instilled ...

  18. Kommest Auto ostmisest huvitub ka Hillar Teder / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2008-01-01

    Kommest Auto ostmise vastu tunnevad huvi suurärimees Andres Sarri, Rootsis Peugeot' sõidukeid müüv Taani päritolu K. W. Bruun Import ja multimiljonär Hillar Teder, kellele kuulub Audisid müüv Reval Auto

  19. The Potsdam Parallel Ice Sheet Model (PISM-PIK – Part 1: Model description

    Directory of Open Access Journals (Sweden)

    R. Winkelmann

    2011-09-01

    Full Text Available We present the Potsdam Parallel Ice Sheet Model (PISM-PIK, developed at the Potsdam Institute for Climate Impact Research to be used for simulations of large-scale ice sheet-shelf systems. It is derived from the Parallel Ice Sheet Model (Bueler and Brown, 2009. Velocities are calculated by superposition of two shallow stress balance approximations within the entire ice covered region: the shallow ice approximation (SIA is dominant in grounded regions and accounts for shear deformation parallel to the geoid. The plug-flow type shallow shelf approximation (SSA dominates the velocity field in ice shelf regions and serves as a basal sliding velocity in grounded regions. Ice streams can be identified diagnostically as regions with a significant contribution of membrane stresses to the local momentum balance. All lateral boundaries in PISM-PIK are free to evolve, including the grounding line and ice fronts. Ice shelf margins in particular are modeled using Neumann boundary conditions for the SSA equations, reflecting a hydrostatic stress imbalance along the vertical calving face. The ice front position is modeled using a subgrid-scale representation of calving front motion (Albrecht et al., 2011 and a physically-motivated calving law based on horizontal spreading rates. The model is tested in experiments from the Marine Ice Sheet Model Intercomparison Project (MISMIP. A dynamic equilibrium simulation of Antarctica under present-day conditions is presented in Martin et al. (2011.

  20. The Potsdam Parallel Ice Sheet Model (PISM-PIK) - Part 1: Model description

    Science.gov (United States)

    Winkelmann, R.; Martin, M. A.; Haseloff, M.; Albrecht, T.; Bueler, E.; Khroulev, C.; Levermann, A.

    2011-09-01

    We present the Potsdam Parallel Ice Sheet Model (PISM-PIK), developed at the Potsdam Institute for Climate Impact Research to be used for simulations of large-scale ice sheet-shelf systems. It is derived from the Parallel Ice Sheet Model (Bueler and Brown, 2009). Velocities are calculated by superposition of two shallow stress balance approximations within the entire ice covered region: the shallow ice approximation (SIA) is dominant in grounded regions and accounts for shear deformation parallel to the geoid. The plug-flow type shallow shelf approximation (SSA) dominates the velocity field in ice shelf regions and serves as a basal sliding velocity in grounded regions. Ice streams can be identified diagnostically as regions with a significant contribution of membrane stresses to the local momentum balance. All lateral boundaries in PISM-PIK are free to evolve, including the grounding line and ice fronts. Ice shelf margins in particular are modeled using Neumann boundary conditions for the SSA equations, reflecting a hydrostatic stress imbalance along the vertical calving face. The ice front position is modeled using a subgrid-scale representation of calving front motion (Albrecht et al., 2011) and a physically-motivated calving law based on horizontal spreading rates. The model is tested in experiments from the Marine Ice Sheet Model Intercomparison Project (MISMIP). A dynamic equilibrium simulation of Antarctica under present-day conditions is presented in Martin et al. (2011).

  1. PRKCI negatively regulates autophagy via PIK3CA/AKT–MTOR signaling

    Energy Technology Data Exchange (ETDEWEB)

    Qu, Liujing; Li, Ge; Xia, Dan; Hongdu, Beiqi; Xu, Chentong; Lin, Xin [Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Sciences Center, Beijing (China); Peking University Center for Human Disease Genomics, Peking University, Beijing (China); Chen, Yingyu, E-mail: yingyu_chen@bjmu.edu.cn [Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Sciences Center, Beijing (China); Peking University Center for Human Disease Genomics, Peking University, Beijing (China)

    2016-02-05

    The atypical protein kinase C isoform PRKC iota (PRKCI) plays a key role in cell proliferation, differentiation, and carcinogenesis, and it has been shown to be a human oncogene. Here, we show that PRKCI overexpression in U2OS cells impaired functional autophagy in normal or cell stress conditions, as characterized by decreased levels of light chain 3B-II protein (LC3B-II) and weakened degradation of endogenous and exogenous autophagic substrates. Conversely, PRKCI knockdown by small interference RNA resulted in opposite effects. Additionally, we identified two novel PRKCI mutants, PRKCI{sup L485M} and PRKCI{sup P560R}, which induced autophagy and exhibited dominant negative effects. Further studies indicated that PRKCI knockdown–mediated autophagy was associated with the inactivation of phosphatidylinositol 3-kinase alpha/AKT–mammalian target of rapamycin (PIK3CA/AKT–MTOR) signaling. These data underscore the importance of PRKCI in the regulation of autophagy. Moreover, the finding may be useful in treating PRKCI-overexpressing carcinomas that are characterized by increased levels of autophagy. - Highlights: • The atypical protein kinase C iota isoform (PRKCI) is a human oncogene. • PRKCI overexpression impairs functional autophagy in U2OS cells. • It reduces LC3B-II levels and weakens SQSTM1 and polyQ80 aggregate degradation. • PRKCI knockdown has the opposite effect. • The effect of PRKCI knockdown is related to PIK3CA/AKT–MTOR signaling inactivation.

  2. Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells

    Science.gov (United States)

    Arjumand, Wani; Merry, Cole D.; Wang, Chen; Saba, Elias; McIntyre, John B.; Fang, Shujuan; Kornaga, Elizabeth; Ghatage, Prafull; Doll, Corinne M.; Lees, Susan P.

    2016-01-01

    The phosphatidylinositol-3 kinase (PI3K)/Akt/mTOR signaling pathway is activated in many human cancers. Previously, we reported that patients with early stage cervical cancer whose tumours harbour PIK3CA exon 9 or 20 mutations have worse overall survival in response to treatment with radiation and cisplatin than patients with wild-type PIK3CA. The purpose of this study was to determine whether PIK3CA-E545K mutation renders cervical cancer cells more resistant to cisplatin and/or radiation, and whether PI3K inhibition reverses the phenotype. We found that CaSki cells that are heterozygous for the PIK3CA-E545K mutation are more resistant to cisplatin or cisplatin plus radiation than either HeLa or SiHa cells that express only wild-type PIK3CA. Similarly, HeLa cells engineered to stably express PIK3CA-E545K were more resistant to cisplatin or cisplatin plus radiation than cells expressing only wild-type PIK3CA or with PIK3CA depleted. Cells expressing the PIK3CA-E545K mutation also had constitutive PI3K pathway activation and increased cellular migration and each of these phenotypes was reversed by treatment with the PI3K inhibitor GDC-0941/Pictilisib. Our results suggests that cervical cancer patients whose tumours are positive for the PIK3CA-E545K mutation may benefit from PI3K inhibitor therapy in concert with standard cisplatin and radiation therapy. PMID:27489350

  3. The sensitivity and efficacy method of PIK3CA exon 9 E545A as a high diagnostic accuracy in breast cancer

    Directory of Open Access Journals (Sweden)

    Desriani

    2018-06-01

    Full Text Available The phosphatidylinositol 3-kinases (PIK3s are lipid kinases. Mutation in the exon 9 and exon 20 determined as a predictive factor in anti-HER-2 therapy. In some countries, such as Singapore, China, and Peru, PIK3CA exon 9 E545A was reported to produce the highest rate of mutation. In this research, we developed and optimized PIK3CA exon 9 E545A detection methods with intercalating dye SYBR Green I based on the Tm Shift approach by using prepared recombinant plasmid pGEMT-easy PIK3CA exon 9 and PIK3CA exon 9 E545A. Recombinant plasmid was used due to the limited number of samples. Methods: Recombinant plasmid was prepared based on manufactured procedures, and this process was then followed by Tm prediction with Poland software, Tm Shift SYBR Green I development, and its characterization (reproducibility, repeatability, sensitivity, qPCR efficiency, and qPCR amplification, respectively. Result: A method for PIK3CA E545A detection based on TM shift SYBR Green I has been successfully developed. The melting temperature for PIK3CA exon 9 was 78.1 ± 0.1 °C, while that for PIK3CA exon E545A was 80.20 °C. The Tm of mutant was the same as that predicted using Polland Software. The reproducibility of the methods was high, with the coefficient values for inter and intra assays were below 10% with a high sensitivity at 1%, while R2 0.99 and PCR efficiency was 97.75%. Conclusion: The results presented here demonstrate that the PIK3CA exon 9 E545A detection method has a good sensitivity and efficacy assay, which proves that the method has a high diagnostic accuracy in breast cancer. Keywords: SYBR Green I, PIK3CA E545A, Breast cancer, Real time PCR, Recombinant plasmid

  4. Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG Study.

    Directory of Open Access Journals (Sweden)

    George Papaxoinis

    Full Text Available The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9 and kinase (exon 20 domains of this protein. The aim of the present study was to examine the role of different types of PIK3CA mutations in combination with molecular biomarkers related to PI3K-AKT signaling in patients with early breast cancer.Tumor tissue samples from 1008 early breast cancer patients treated with adjuvant chemotherapy in two similar randomized trials of HeCOG were examined. Tumors were subtyped with immunohistochemistry (IHC and FISH for ER, PgR, Ki67, HER2 and androgen receptor (AR. PIK3CA mutations were analyzed by Sanger sequencing (exon 20 and qPCR (exon 9 (Sanger/qPCR mutations. In 610 cases, next generation sequencing (NGS PIK3CA mutation data were also available. PIK3CA mutations and PTEN protein expression (IHC were analyzed in luminal tumors (ER and/or PgR positive, molecular apocrine carcinomas (MAC; ER/PgR negative / AR positive and hormone receptor (ER/PgR/AR negative tumors.PIK3CA mutations were detected in 235/1008 tumors (23% with Sanger/qPCR and in 149/610 tumors (24% with NGS. Concordance between the two methods was good with a Kappa coefficient of 0.76 (95% CI 0.69-0.82. Lobular histology, low tumor grade and luminal A tumors were associated with helical domain mutations (PIK3CAhel, while luminal B with kinase domain mutations (PIK3CAkin. The overall incidence of PIK3CA mutations was higher in luminal as compared to MAC and hormone receptor negative tumors (p = 0.004. Disease-free and overall survival did not significantly differ with respect to PIK3CA mutation presence and type. However, a statistically significant interaction between PIK3CA mutation status and PTEN low protein expression with regard to prognosis was identified.The present study did not show any prognostic significance of specific PIK3CA mutations in a large group of predominantly lymph-node positive breast cancer

  5. PIK3CA-associated developmental disorders exhibit distinct classes of mutations with variable expression and tissue distribution

    NARCIS (Netherlands)

    Mirzaa, Ghayda; Timms, Andrew E.; Conti, Valerio; Boyle, Evan August; Girisha, Katta M.; Martin, Beth; Kircher, Martin; Olds, Carissa; Juusola, Jane; Collins, Sarah; Park, Kaylee; Carter, Melissa; Glass, Ian; Krägeloh-Mann, Inge; Chitayat, David; Parikh, Aditi Shah; Bradshaw, Rachael; Torti, Erin; Braddock, Stephen; Burke, Leah; Ghedia, Sondhya; Stephan, Mark; Stewart, Fiona; Prasad, Chitra; Napier, Melanie; Saitta, Sulagna; Straussberg, Rachel; Gabbett, Michael; O'Connor, Bridget C.; Keegan, Catherine E.; Yin, Lim Jiin; Lai, Angeline Hwei Meeng; Martin, Nicole; McKinnon, Margaret; Addor, Marie-Claude; Boccuto, Luigi; Schwartz, Charles E.; Lanoel, Agustina; Conway, Robert L.; Devriendt, Koenraad; Tatton-Brown, Katrina; Pierpont, Mary Ella; Painter, Michael; Worgan, Lisa; Reggin, James; Hennekam, Raoul; Tsuchiya, Karen; Pritchard, Colin C.; Aracena, Mariana; Gripp, Karen W.; Cordisco, Maria; Esch, Hilde Van; Garavelli, Livia; Curry, Cynthia; Goriely, Anne; Kayserilli, Hulya; Shendure, Jay; Graham, John; Guerrini, Renzo; Dobyns, William B.

    2016-01-01

    Mosaicism is increasingly recognized as a cause of developmental disorders with the advent of next-generation sequencing (NGS). Mosaic mutations of PIK3CA have been associated with the widest spectrum of phenotypes associated with overgrowth and vascular malformations. We performed targeted NGS

  6. Mass-spectrometer of knock-on nuclei for reactor 'Pik'

    International Nuclear Information System (INIS)

    Begzhanov, P.B.; Nazarov, A.G.; Petrov, G.A.; Pikul', V.P.

    1999-01-01

    For reactor 'Pik' (that is being built in St. Petersburg Institute of Nuclear Physics) there was designed a universal two shoulder mass-spectrometer for non-decelerated fission products (FP) of nuclei. The spectrometer helps to obtain different values of linear magnification, dispersion, aberration coefficients and transmission without making structural changes in the device. To separate FP for one shoulder of spectrometer we chose ion-optical scheme (IOS) consisting of three electrostatic analyzers and three-sectional magnet 'JOSEF' that had high dispersion by masses at small deflection radius. IOS calculations of mass-spectrometer were performed with the help of program TRANSVOL (transfer of phase volume) designed basing on TRIO program. The program allows calculating of complete IOS transmission with taking into account elements aperture and beam officering

  7. Tallinna Lennujaama kauba- ja tolliterminaal. Lennujaama 2, Tallinn / Andres Põime

    Index Scriptorium Estoniae

    Põime, Andres

    1998-01-01

    Kaubateeninduskeskuse puhul on tegemist suure, plaanimõõtudes 36x102 meetrise metallkonstruktsioonis, sandwich tüüpi paneelidega kaetud laohoonega, kus ühelt poolt tuuakse tollitav kaup lennukitelt sisse ja teiselt poolt viiakse tollitud kaup välja. Peatöövõtja : Normanni Linnagrupi AS. Ehitaja : Merko. Peaprojekteerija : K-Projekt. Arhitektuurne lahendus : Stuudio 3. Arhitekt Andres Põime ; töögrupp Vivian Oruvee, Tiiu Raudsepp, Reet Põime. Projekt 1997-98, valmis 1998.

  8. André Lefevere and his Manipulation School

    OpenAIRE

    Šmrha, Jan

    2015-01-01

    This theoretical and historiographical thesis examines the theoretical work of the Translation Studies scholar André Lefevere. It focuses primarily on the analysis of Lefevere's work in the context of the development of Translation Studies (particularly in connection with the development of Descriptive Translation Studies, the formation of the "Manipulation School" and the cultural and sociological turns in Translation Studies). The thesis covers Lefevere's theoretical underpinnings, the grad...

  9. Sobre "La tortuga" de Andrés Holguin

    Directory of Open Access Journals (Sweden)

    José Puben

    1961-04-01

    Full Text Available Andrés Holguín no es el primero y, ciertamente, no será el último escritor contemporáneo que, interesado por el problema de los animales que han logrado dimensión fantástica, se proponga, con interés intelectual, analizar e investigar la dimensión e importancia de un animal en la historia de la cultura.

  10. Mida teeks tulevane kultuuriminister 500 miljoni krooniga? / interv. Andres Keil

    Index Scriptorium Estoniae

    2007-01-01

    Suuremate erakondade kultuurispetsialistid (kultuuriministrikandidaadid) Urmas Paet, Andres Herkel, Peeter Jalakas, Indrek Saar, Jaak Allik, samuti kultuuriminister Raivo Palmaru vastavad küsimustele, mis on suurimad ohud eesti keele ja rahvuskultuuri säilimisele, milline on kultuuriministeeriumi ja -ministri portfelli staatus praeguses valitsuses, kas kultuuri rahastamine riigieelarvest on piisav, mille poolest erineb nende erakonna nägemus kultuuripoliitikast teiste erakondade omast, kuhu nad suunaksid 50, 500 miljonit, kui see oleks nende käsutuses

  11. Revolver, kala ja harmoonia / Andres Tolts ; intervjueerinud Kadri Karro

    Index Scriptorium Estoniae

    Tolts, Andres, 1949-2014

    2009-01-01

    Andres Toltsi juubelinäitused Tallinnas: "Näitus" Tallinna Kunstihoones 25.9-25.10, "Asjad" Hobusepea galeriis 30.9-12.10, "Juubelinäitus" Haus galeriis 8.10-13.11. Kunstnik räägib oma loomingust, revolvri ja kala motiivist oma töödes, mõttekaaslusest, eestiaegsest maailmavaatest, harmooniast ja isikupärast kunstis ning elus, ilust ja inetusest, kaasaja kunstnike vajadusest oma loomingut sõnade abil seletada

  12. Kutseharidust hakkab muutma uus paradigma / André Huigens ; intervjueerinud Veiko Belials

    Index Scriptorium Estoniae

    Huigens, André

    2011-01-01

    Intervjuu Luual toimunud rahvusvahelise kutsehariduse alase seminari peaesineja, André Huigensiga, kes on Euroopa kutseõppe arenduskeskuse Cedefop kvalifikatsiooniraamistiku ekspert Hollandi Wellantcollege’ist

  13. Physiological Levels of Pik3ca H1047R Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ERα-Positive Tumors

    Science.gov (United States)

    Tikoo, Anjali; Roh, Vincent; Montgomery, Karen G.; Ivetac, Ivan; Waring, Paul; Pelzer, Rebecca; Hare, Lauren; Shackleton, Mark; Humbert, Patrick; Phillips, Wayne A.

    2012-01-01

    PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors including breast cancers. To better understand the role of mutant PIK3CA in the initiation and/or progression of breast cancer, we have generated mice with a conditional knock-in of the common activating mutation, Pik3caH1047R, into one allele of the endogenous gene in the mammary gland. These mice developed a ductal anaplasia and hyperplasia by 6 weeks of age characterized by multi-layering of the epithelial lining of the mammary ducts and expansion of the luminal progenitor (Lin−; CD29lo; CD24+; CD61+) cell population. The Pik3caH1047R expressing mice eventually develop mammary tumors with 100% penetrance but with a long latency (>12 months). This is significantly longer than has been reported for transgenic models where expression of the mutant Pik3ca is driven by an exogenous promoter. Histological analysis of the tumors formed revealed predominantly ERα-positive fibroadenomas, carcinosarcomas and sarcomas. In vitro induction of Pik3caH1047R in immortalized mammary epithelial cells also resulted in tumor formation when injected into the mammary fat pad of immunodeficient recipient mice. This novel model, which reproduces the scenario of a heterozygous somatic mutation occurring in the endogenous PIK3CA gene, will thus be a valuable tool for investigating the role of Pik3caH1047R mutation in mammary tumorigenesis both in vivo and in vitro. PMID:22666336

  14. Highly sensitive detection of the PIK3CAH1047R mutation in colorectal cancer using a novel PCR-RFLP method

    International Nuclear Information System (INIS)

    Li, Wan-Ming; Hu, Ting-Ting; Zhou, Lin-Lin; Feng, Yi-Ming; Wang, Yun-Yi; Fang, Jin

    2016-01-01

    The PIK3CA H1047R mutation is considered to be a potential predictive biomarker for EGFR-targeted therapies. In this study, we developed a novel PCR-PFLP approach to detect the PIK3CA H1047R mutation in high effectiveness. A 126-bp fragment of PIK3CA exon-20 was amplified by PCR, digested with FspI restriction endonuclease and separated by 3 % agarose gel electrophoresis for the PCR-RFLP analysis. The mutant sequence of the PIK3CA H1047R was spiked into the corresponding wild-type sequence in decreasing ratios for sensitivity analysis. Eight-six cases of formalin-fixed paraffin-embedded colorectal cancer (CRC) specimens were subjected to PCR-RFLP to evaluate the applicability of the method. The PCR-RFLP method had a capability to detect as litter as 0.4 % of mutation, and revealed 16.3 % of the PIK3CA H1047R mutation in 86 CRC tissues, which was significantly higher than that discovered by DNA sequencing (9.3 %). A positive association between the PIK3CA H1047R mutation and the patients’ age was first found, except for the negative relationship with the degree of tumor differentiation. In addition, the highly sensitive detection of a combinatorial mutation of PIK3CA, KRAS and BRAF was achieved using individual PCR-RFLP methods. We developed a sensitive, simple and rapid approach to detect the low-abundance PIK3CA H1047R mutation in real CRC specimens, providing an effective tool for guiding cancer targeted therapy

  15. Physiological levels of Pik3ca(H1047R mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.

    Directory of Open Access Journals (Sweden)

    Anjali Tikoo

    Full Text Available PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors including breast cancers. To better understand the role of mutant PIK3CA in the initiation and/or progression of breast cancer, we have generated mice with a conditional knock-in of the common activating mutation, Pik3ca(H1047R, into one allele of the endogenous gene in the mammary gland. These mice developed a ductal anaplasia and hyperplasia by 6 weeks of age characterized by multi-layering of the epithelial lining of the mammary ducts and expansion of the luminal progenitor (Lin(-; CD29(lo; CD24(+; CD61(+ cell population. The Pik3ca(H1047R expressing mice eventually develop mammary tumors with 100% penetrance but with a long latency (>12 months. This is significantly longer than has been reported for transgenic models where expression of the mutant Pik3ca is driven by an exogenous promoter. Histological analysis of the tumors formed revealed predominantly ERα-positive fibroadenomas, carcinosarcomas and sarcomas. In vitro induction of Pik3ca(H1047R in immortalized mammary epithelial cells also resulted in tumor formation when injected into the mammary fat pad of immunodeficient recipient mice. This novel model, which reproduces the scenario of a heterozygous somatic mutation occurring in the endogenous PIK3CA gene, will thus be a valuable tool for investigating the role of Pik3ca(H1047R mutation in mammary tumorigenesis both in vivo and in vitro.

  16. Dual HER2\\PIK3CA targeting overcomes single-agent acquired resistance in HER2 amplified uterine serous carcinoma cell lines in vitro and in vivo

    Science.gov (United States)

    Lopez, Salvatore; Cocco, Emiliano; Black, Jonathan; Bellone, Stefania; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Schwab, Carlton L.; English, Diana P.; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E.; Terranova, Corrado; Angioli, Roberto; Santin, Alessandro D.

    2015-01-01

    HER2/neu gene amplification and PIK3CA driver mutations are common in uterine serous carcinoma (USC), and may represent ideal therapeutic targets against this aggressive variant of endometrial cancer. We examined the sensitivity to neratinib, taselisib and the combination of the two compounds in in vitro and in vivo experiments using PIK3CA mutated and PIK3CA-wild type HER2/neu amplified USC cell lines. Cell viability and cell cycle distribution were assessed using flow-cytometry assays. Downstream signaling was assessed by immunoblotting. Preclinical efficacy of single versus dual inhibition was evaluated in vivo using two USC-xenografts. We found both single agent neratinib and taselisib to be active but only transiently effective in controlling the in vivo growth of USC xenografts harboring HER2/neu gene amplification with or without oncogenic PIK3CA mutations. In contrast, the combination of the two inhibitors caused a stronger and long lasting growth inhibition in both USC xenografts when compared to single agent therapy. Combined targeting of HER2 and PIK3CA was associated with a significant and dose-dependent increase in the percentage of cells in the G0/G1 phase of the cell cycle and a dose-dependent decline in the phosphorylation of S6. Importantly, dual inhibition therapy initiated after tumor progression in single agent-treated mice was still remarkably effective at inducing tumor regression in both large PIK3CA or pan-ErbB inhibitor-resistant USC xenografts. Dual HER2/PIK3CA blockade may represent a novel therapeutic option for USC patients harboring tumors with HER2/neu gene amplification and mutated or wild type PIK3CA resistant to chemotherapy. PMID:26333383

  17. Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo.

    Science.gov (United States)

    Lopez, Salvatore; Cocco, Emiliano; Black, Jonathan; Bellone, Stefania; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Schwab, Carlton L; English, Diana P; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Terranova, Corrado; Angioli, Roberto; Santin, Alessandro D

    2015-11-01

    HER2/neu gene amplification and PIK3CA driver mutations are common in uterine serous carcinoma (USC) and may represent ideal therapeutic targets against this aggressive variant of endometrial cancer. We examined the sensitivity to neratinib, taselisib, and the combination of the two compounds in in vitro and in vivo experiments using PIK3CA-mutated and PIK3CA wild-type HER2/neu-amplified USC cell lines. Cell viability and cell-cycle distribution were assessed using flow-cytometry assays. Downstream signaling was assessed by immunoblotting. Preclinical efficacy of single versus dual inhibition was evaluated in vivo using two USC xenografts. We found both single-agent neratinib and taselisib to be active but only transiently effective in controlling the in vivo growth of USC xenografts harboring HER2/neu gene amplification with or without oncogenic PIK3CA mutations. In contrast, the combination of the two inhibitors caused a stronger and long-lasting growth inhibition in both USC xenografts when compared with single-agent therapy. Combined targeting of HER2 and PIK3CA was associated with a significant and dose-dependent increase in the percentage of cells in the G0-G1 phase of the cell cycle and a dose-dependent decline in the phosphorylation of S6. Importantly, dual inhibition therapy initiated after tumor progression in single-agent-treated mice was still remarkably effective at inducing tumor regression in both large PIK3CA and pan-ErbB inhibitor-resistant USC xenografts. Dual HER2/PIK3CA blockade may represent a novel therapeutic option for USC patients harboring tumors with HER2/neu gene amplification and mutated or wild-type PIK3CA resistant to chemotherapy. ©2015 American Association for Cancer Research.

  18. Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas.

    Science.gov (United States)

    Yamaguchi, Hiroshi; Kuboki, Yuko; Hatori, Takashi; Yamamoto, Masakazu; Shiratori, Keiko; Kawamura, Shunji; Kobayashi, Makio; Shimizu, Michio; Ban, Shinichi; Koyama, Isamu; Higashi, Morihiro; Shin, Nobuhiro; Ishida, Kazuyuki; Morikawa, Takanori; Motoi, Fuyuhiko; Unno, Michiaki; Kanno, Atsushi; Satoh, Kennichi; Shimosegawa, Tooru; Orikasa, Hideki; Watanabe, Tomoo; Nishimura, Kazuhiko; Harada, Youji; Furukawa, Toru

    2011-12-01

    Intraductal tubulopapillary neoplasm (ITPN) is a recently recognized rare variant of intraductal neoplasms of the pancreas. Molecular aberrations underlying the neoplasm remain unknown. We investigated somatic mutations in PIK3CA, PTEN, AKT1, KRAS, and BRAF. We also investigated aberrant expressions of phosphorylated AKT, phosphatase and tensin homolog (PTEN), tumor protein 53 (TP53), SMAD4, and CTNNB1 in 11 cases of ITPNs and compared these data with those of 50 cases of intraductal papillary mucinous neoplasm (IPMN), another distinct variant of pancreatic intraductal neoplasms. Mutations in PIK3CA were found in 3 of 11 ITPNs but not in IPMNs (P = 0.005; Fisher exact test). In contrast, mutations in KRAS were found in none of the ITPNs but were found in 26 of the 50 IPMNs (P = 0.001; Fisher exact test). PIK3CA mutations were associated with strong expression of phosphorylated AKT (P AKT was apparent in most ITPNs but only in a few IPMNs (P SMAD4, and CTNNB1 were not statistically different between these neoplasms. Mutations in PIK3CA and the expression of phosphorylated AKT were not associated with age, sex, tissue invasion, and patients' prognosis in ITPNs. These results indicate that activation of the phosphatidylinositol 3-kinase pathway may play a crucial role in ITPNs but not in IPMNs. In contrast, the mutation in KRAS seems to play a major role in IPMNs but not in ITPNs. The activated phosphatidylinositol 3-kinase pathway may be a potential target for molecular diagnosis and therapy of ITPNs.

  19. PIK3CA-associated developmental disorders exhibit distinct classes of mutations with variable expression and tissue distribution

    OpenAIRE

    Mirzaa, Ghayda; Timms, Andrew E.; Conti, Valerio; Boyle, Evan August; Girisha, Katta M.; Martin, Beth; Kircher, Martin; Olds, Carissa; Juusola, Jane; Collins, Sarah; Park, Kaylee; Carter, Melissa; Glass, Ian; Kr?geloh-Mann, Inge; Chitayat, David

    2016-01-01

    Mosaicism is increasingly recognized as a cause of developmental disorders with the advent of next-generation sequencing (NGS). Mosaic mutations of PIK3CA have been associated with the widest spectrum of phenotypes associated with overgrowth and vascular malformations. We performed targeted NGS using 2 independent deep-coverage methods that utilize molecular inversion probes and amplicon sequencing in a cohort of 241 samples from 181 individuals with brain and/or body overgrowth. We identifie...

  20. Tehnikahuviline juht ootab töötajalt ausust / Andres Haamer ; interv. Urve Vilk

    Index Scriptorium Estoniae

    Haamer, Andres, 1942-

    2008-01-01

    Overall Eesti nõukogu esimees Andres Haamer vastab oma lapsepõlve, haridusteed, karjääri, AS-i Overalli asutamist, oma tööülesandeid ning ühiskondlikus elus osalemist puudutavatele küsimustele. Kommenteerib Valdo Kalm. Lisa: Andres Haamer; Edu võtmed

  1. Globaliseerumine : oht või võimalus? / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2007-01-01

    Globaliseerumise ja võrgustumise muutumine võimaluseks või ohuks sõltub konkreetse riigi majanduse ja tööturu kohanemisvõimest. Globaalsete finantsvoogude kirjeldus, kapitali ja Eestisse tulevate rahavoogude analüüs ning hinnang Eesti tööturu paindlikkusele ja ettevõtjate innovatiivsusele. Graafikud: Otse- ja portfelliinvesteeringute ning laenude sissevool Eestisse 1992-2006; Diagramm: Eesti tööjõuturg sammub Ameerika jälgedes. Vt. samas: Andres Saarniit. Raha ei ole kuhugi kadunud

  2. Measurement of glacier velocity at Pik Lenin, Tajikistan, by feature tracking

    Science.gov (United States)

    Kumari, S.; Ghosh, S. K.; Buchroithner, M. F.

    2014-11-01

    Glaciers, especially in mountain area are sensitive indicators of climate fluctuations and also contribute to present rates of sea level rise. In Central Asia, these glaciers are the primary resource for fresh water. Understanding the seasonal behavior of these glaciers would help to make efficient use of the available water reservoir. Different methods have been employed to study glacier displacements in past. The conventional survey techniques are very cost-intensive and highly depend on accessibility to high mountain glaciers also directs us to look for new ways to study these areas. Here remote sensing comes in handy with freely available data and a good coverage with high spatial and temporal resolution. Optical satellite imagery, available free can be effectively used for research purpose. The glacier in this region fed lake Karakul (380 km2), the largest Lake in Tajikistan. The objective is to study the displacement tendency of the Glacier in Pik Lenin area using Landsat 7 dataset. Normalized cross correlation algorithm has been implemented via CIAS to estimate the motion of glacier surface. A number of combination of reference block and search area size were tested for 30 m resolution dataset. As a result the specifications: reference block size of 15 pixels and search area size of 10 pixels was found out as the best set of parameters and considered for further processing. The study derives a reliable set of data depicting the velocities in the glacier which after post processing shows peak velocity of 121 m/y of the glacier.

  3. The genusGuenthera Andr. in Bess. (Brassicaceae, Brassiceae

    Directory of Open Access Journals (Sweden)

    Gómez-Campo, César

    2003-12-01

    Full Text Available A group of nine species -now included in Brassica— differ from all the other species in several characters, mainly in the stylar portion of their pistils always without seed primordia. Also in their branched subterranean stem (caudex with several leaf rosettes, their leaves entire to deeply pinnatifid but never pinnatisect, their shallowly notched cotyledons and their flattened, elliptic or ovoid seed contour. It is suggested to include these species under the generic denomination Guenthera Andr, in Bess. New ñames for the species and subspecies are provided, as well as a determination key for the species.Un grupo de nueve especies actualmente incluidas en Brassica difiere de todas las demás por varios caracteres, sobre todo por la porción estilar de sus pistilos, que siempre carece de primordios seminales. Además, por su tallo subterráneo ramificado, que forma un cáudex con varias rosetas; sus hojas de enteras hasta profundamente pinnatífidas, pero nunca pinnatisectas; sus cotiledones solo muy ligeramente escotados, y sus semillas, que tienden a ser elipsoidales o aplanadas. Se propone agruparlas todas bajo la denominación genérica Guenthera Andr, in Bess. Se detallan los nuevos nombres para las especies y Subespecies y se añade una clave para diferenciar las especies.

  4. Pomeranchuk Prize awarded to André Martin

    CERN Multimedia

    Jordan Juras

    2010-01-01

    Professor André Martin has been awarded the I.Ya.Pomeranchuk Prize 2010, alongside Professor Valentine Zakharov.   André Martin, CERN theorist, pictured at the ceremony held in honour of his 80th birthday (August 2009). Established by the Institute of Theoretical and Experimental Physics (ITEP) in memory of an outstanding scientist Isaak Yakovlevich Pomeranchuk, the prize is awarded for the study of analytic properties of the scattering amplitude; which lead to the Froissart—Martin bound on the cross section growth with energy. The prize comes as a great honor for Martin, who was in fact a good friend of Mr. Pomeranchuk, "I am surprised and delighted to learn that I will be receiving the 2010 Pomeranchuk Prize. I was an admirer of Pomeranchuk and we shared a great friendship. I met with him for the last time in Erevan (Armenia) in 1965. As a good-bye, he told me, 'Analyticity exists'. This is precisely what I proved to earn the prize"....

  5. KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors.

    Directory of Open Access Journals (Sweden)

    Ignacio Garrido-Laguna

    Full Text Available To evaluate clinicopathologic and molecular features of patients with metastatic colorectal cancer (mCRC and their outcomes in early-phase trials using pathway-targeting agents.We analyzed characteristics of 238 patients with mCRC referred to the phase 1 trials unit at MD Anderson Cancer Center. KRAS, PIK3CA and BRAF status were tested using PCR-based DNA sequencing.Fifty-one percent of patients harbored KRAS mutations; 15% had PIK3CA mutations. In the multivariate regression model for clinical characteristics KRAS mutations were associated with an increased incidence of lung and bone metastases and decreased incidence of adrenal metastases; PIK3CA mutations were marginally correlated with mucinous tumors (p = 0.05. In the univariate analysis, KRAS and PIK3CA mutations were strongly associated. Advanced Duke's stage (p<0.0001 and KRAS mutations (p = 0.01 were the only significant independent predictors of poor survival (Cox proportional hazards model. Patients with PIK3CA mutations had a trend toward shorter progression-free survival when treated with anti-EGFR therapies (p = 0.07. Eighteen of 78 assessable patients (23% treated with PI3K/Akt/mTOR axis inhibitors achieved stable disease [SD] ≥6 months or complete response/partial response (CR/PR, only one of whom were in the subgroup (N = 15 with PIK3CA mutations, perhaps because 10 of these 15 patients (67% had coexisting KRAS mutations. No SD ≥6 months/CR/PR was observed in the 10 patients treated with mitogen-activating protein kinase (MAPK pathway targeting drugs.KRAS and PIK3CA mutations frequently coexist in patients with colorectal cancer, and are associated with clinical characteristics and outcome. Overcoming resistance may require targeting both pathways.

  6. Oligonucleotide PIK3CA/Chromosome 3 Dual in Situ Hybridization Automated Assay with Improved Signals, One-Hour Hybridization, and No Use of Blocking DNA.

    Science.gov (United States)

    Zhang, Wenjun; Hubbard, Antony; Baca-Parkinson, Leslie; Stanislaw, Stacey; Vladich, Frank; Robida, Mark D; Grille, James G; Maxwell, Daniel; Tsao, Tsu-Shuen; Carroll, William; Gardner, Tracie; Clements, June; Singh, Shalini; Tang, Lei

    2015-09-01

    The PIK3CA gene at chromosome 3q26.32 was found to be amplified in up to 45% of patients with squamous cell carcinoma of the lung. The strong correlation between PIK3CA amplification and increased phosphatidylinositol 3-kinase (PI3K) pathway activities suggested that PIK3CA gene copy number is a potential predictive biomarker for PI3K inhibitors. Currently, all microscopic assessments of PIK3CA and chromosome 3 (CHR3) copy numbers use fluorescence in situ hybridization. PIK3CA probes are derived from bacterial artificial chromosomes whereas CHR3 probes are derived mainly from the plasmid pHS05. These manual fluorescence in situ hybridization assays mandate 12- to 18-hour hybridization and use of blocking DNA from human sources. Moreover, fluorescence in situ hybridization studies provide limited morphologic assessment and suffer from signal decay. We developed an oligonucleotide-based bright-field in situ hybridization assay that overcomes these shortcomings. This assay requires only a 1-hour hybridization with no need for blocking DNA followed by indirect chromogenic detection. Oligonucleotide probes produced discrete and uniform CHR3 stains superior to those from the pHS05 plasmid. This assay achieved successful staining in 100% of the 195 lung squamous cell carcinoma resections and in 94% of the 33 fine-needle aspirates. This robust automated bright-field dual in situ hybridization assay for the simultaneous detection of PIK3CA and CHR3 centromere provides a potential clinical diagnostic method to assess PIK3CA gene abnormality in lung tumors. Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  7. André-Louis Cholesky mathematician, topographer and army officer

    CERN Document Server

    Brezinski, Claude

    2014-01-01

    Outside the professional circles of topography and applied mathematics, the life and work of André-Louis Cholesky (1875–1918) are still relatively unknown to the scientific community. This new book appreciably widens the exposure of his remarkable personal achievements in topography and mathematics to a much larger international audience.   Cholesky is also interesting to historians because he is a perfect representative of the "scientists engineers" that, since the early 19th century, had issued from the French scientific high schools. Because they had received a high level of mathematical education, they were able to innovate in their practice of engineering. In the case of Cholesky, this resulted in original contributions in artillery, topography, numerical analysis and graphical calculation. In addition, the book places his education and works within the history of several European countries through the 17th to 19th centuries.   The book begins with Cholesky's biography, followed by his family’s hi...

  8. Pierre Darriulat is awarded the André Lagarrigue Prize

    CERN Multimedia

    2009-01-01

    Pierre Darriulat at the VATLY Laboratory in Hanoï. Former CERN Research Director, Pierre Darriulat, who is now Professor of Physics at VATLY in Hanoi (Vietnam), has won the 2008 André Lagarrigue Prize. This prize, instituted by the Linear Accelerator Laboratory (LAL) at Orsay under the aegis of the French Physical Society, is awarded to front-line researchers who have had responsibility for machine/detector construction and derived maximum scientific benefit from such projects, performed in a French laboratory or in close collaboration with French groups. Pierre Darriulat has received the award in recognition of his outstanding career at the CEA, at LBL (Berkeley) and at CERN from 1964 onwards. At CERN he managed the experiments at the Intersecting Storage Rings (ISR) before taking charge of the UA2 collaboration from 1980 to 1986, which participated in decisive discoveries at the ppbar collider. In particular, in 1982, the UA2 experiment began observing high trans...

  9. André Gide, Gide & Amrouche. Correspondance (1928-1950)

    OpenAIRE

    Amadessi, Veronica

    2016-01-01

    En 1928, le jeune Jean el-Mouhoub Amrouche captive l’attention d’André Gide dans une lettre qu’il lui adresse personnellement. À cette époque, la réputation de l’auteur de L’Immoraliste ne cesse de grandir, alors que l’expéditeur n’est qu’un «brillant» normalien inconnu au grand public. Il s’agit toutefois d’un jeune kabyle aux idées bien précises, qui exprime, dans cette première missive, sa volonté de se faire le porte-parole de l’identité kabyle tout en préservant son amour pour la France....

  10. PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

    OpenAIRE

    Anderson, Grace R.; Wardell, Suzanne E.; Cakir, Merve; Crawford, Lorin; Leeds, Jim C.; Nussbaum, Daniel P.; Shankar, Pallavi S.; Soderquist, Ryan S.; Stein, Elizabeth M.; Tingley, Jennifer P.; Winter, Peter S.; Zieser-Misenheimer, Elizabeth K.; Alley, Holly M.; Yllanes, Alexander; Haney, Victoria

    2016-01-01

    Therapies that efficiently induce apoptosis are likely to be required for durable clinical responses in patients with solid tumors. Using a pharmacological screening approach, we discovered that the combined inhibition of BCL-XL and the mTOR/4E-BP axis results in selective and synergistic induction of apoptosis in cellular and animal models of PIK3CA mutant breast cancers, including triple negative tumors. Mechanistically, inhibition of mTOR/4E-BP suppresses MCL-1 protein translation only in ...

  11. Väitlus tumma tekstiga : Hans Anton Schults ja Andres Saal / Katre Kikas

    Index Scriptorium Estoniae

    Kikas, Katre

    2006-01-01

    Artiklis käsitletakse H. A. Schults'i (1866-1905) 1903. a. Jakob Hurdale saadetud kirjutisi, kus ta polemiseerib oma kaasaegse Andres Saaliga arutledes "vanade eestlaste" moraali, rahvuse ja religiooni teemal

  12. Läänemere strateegia arvestab kodanike ettepanekutega / Jose Palma Andres ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Palma Andres, Jose

    2008-01-01

    Euroopa Komisjoni regionaalpoliitika peadirektoraadi direktor Jose Palma Andres vastab küsimustele, mis puudutavad avalikku debatti Läänemere strateegia üle ning Venemaa partnerlust Läänemere strateegias. Lisa: [Läänemere strateegia

  13. Tallinna idee / Andres Alver, Ott Alver, Marten Kaevats ; intervjueerinud Margit Mutso ; kommenteerinud Douglas Gordon

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2011-01-01

    17. veebruaril esitleti raamatut "Tallinna idee", mis on koostatud Eesti Kunstiakadeemia 4. kursuse arhitektuuritudengite kursuseprojektide põhjal. Tallinna teemal vestlevad tudengid Ott Alver ja Marten Kaevats ning nende juhendaja professor Andres Alver

  14. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva, 1980-

    2011-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  15. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva

    2006-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  16. Noblessneri Loomemaja = Noblessner Creative house / Rasmus Tamme, Jaanus Saarepera, Eero Jürgenson, Andres Jomp

    Index Scriptorium Estoniae

    2015-01-01

    Noblessneri Loomemaja Tallinnas Tööstuse 48/Peetri 11, valminud 2014. Arhitektid Rasmus Tamme, Jaanus Saarepera (ARS Projekt), sisearhitektid Eero Jürgenson, Andres Jomp (ARS Projekt). 2014. aasta Kultuurkapitali Arhitektuuripreemia kandidaat

  17. Giving Voice: Narrating silence, history and memory in André Brink ...

    African Journals Online (AJOL)

    Giving Voice: Narrating silence, history and memory in André Brink\\'s The Other Side of Silence and Before I Forget. ... Both narrators, though, draw attention to the problems associated with this reconstructive and potentially ... Article Metrics.

  18. André-Philip Lemke näitus Tallinnas / Mari Laaniste

    Index Scriptorium Estoniae

    Laaniste, Mari, 1977-

    1998-01-01

    Saksa kunstniku André-Philip Lemke (1970) näitus "Üks-üks armsa Jumala kasuks" 17. augustist Saksa Kultuuriinstituudis. Tööd on valgele paberile tavalise sinise pastapliiatsiga kirjutatud-joonistatud

  19. Korterelamu Tallinnas Weizenbergi 29 = Apartment Building in Tallinn, at 29 Weizenbergi Street / Andres Alver

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2001-01-01

    Puitvoodriga betoonist kastjas hoone. Projekteerija Alver Trummal Arhitektid. Arhitektid Andres Alver ja Tarmo Laht. Eriosad: Eesti Projekt. Projekt 1998, valmis 2000. 3 ill.: põhiplaan, välisvaade, Pille Lausmäe kujundatud korteri vaade

  20. Eestlane juhib Ukrainas EBRD investeeringuid / Andre Küüsvek ; interv. Henrik Ilves

    Index Scriptorium Estoniae

    Küüsvek, Andre

    2008-01-01

    Seni Euroopa Rekonstruktsiooni- ja Arengupanga (EBRD) Kasahstani osakonda juhtinud Andre Küüsvek valiti juhtima EBRD investeeringuid Ukrainas. Tänavu on plaanis investeerida Ukrainas 1,5 mld. dollarit

  1. Põlvas tuli esitusele Andre Laine 29 tantsu / Mati Määrits

    Index Scriptorium Estoniae

    Määrits, Mati, 1958-

    2008-01-01

    Põlva Kultuuri- ja Huvikeskuses sai näha Põlvamaa Koolitantsu maakondlikku eelvooru. 52st tantsust 29 tantsu autor on Andre Laine. Kommenteerib ka Tartu Ülikooli Viljandi Kultuuriakadeemia lavakunstide osakonna tantsukunsti õppejõud Kai Valtna

  2. Raio Piiroja : mängijatest ei suudetud maksimumi pigistada / Andres Kalvik

    Index Scriptorium Estoniae

    Kalvik, Andres, 1982-

    2007-01-01

    Vt. ka Postimees : na russkom jazõke 19. nov., lk. 13. Eesti koondis võlgneb EM-valikturniiri viimase kohtumise 2:0 Andorra üle suuresti Andres Operile. Kommenteerib Andorra koondise peatreener David Rodrigo

  3. Haapsalu Gümnaasiumi võimla = Haapsalu Gymnasium Gym / Andres Alver

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2001-01-01

    Projekteerija: Alver Trummal Arhitektid OÜ. Arhitektid Andres Alver, Sven Koppel, Tarmo Laht, Ulla Mets. Projekt 1998-1999, hoone valmis 2001. 11 ill.: asendi- ja korruse plaan, pikilõige, välis- ja sisevaated

  4. Proceedings of the 3. Summer School Jorge Andre Swieca in Nuclear Physics

    International Nuclear Information System (INIS)

    Lima, C.L.; Nemes, M.C.; Wolynec, E.

    1987-01-01

    This book contents the lectures and seminars presented during the Jorge Andre Swieca III Summer School-Nuclear Physics 1987 which happened in February 1987 in Itaipava - Rio de Janeiro - Brazil. (A.C.A.S.) [pt

  5. MASSIVE QUANTITIES OF PELAGIC Sargassum ON THE SHORES OF SAN ANDRES ISLAND, SOUTHWESTERN CARIBBEAN

    Directory of Open Access Journals (Sweden)

    Brigitte GAVIO

    2015-01-01

    Cantidades masivas de Sargassum pelágicos en las costas de San Andrés Isla, Caribe suroccidental Se reporta la llegada de una biomasa inusual de Sargassum flotante, compuesta por las especies S. fluitans y S. natans, a la costa nororiental de la isla de San Andrés. La época y el tamaño del evento nunca habían sido reportados anteriormente para la isla.

  6. Alkohol, andre rusmidler og vold i epidemiologisk perspektiv

    Directory of Open Access Journals (Sweden)

    Kai Pernanen

    2009-10-01

    Full Text Available  SAMMENDRAGDen medisinske interessen for vold og voldsskader har økt kraftig i løpet av de siste to tiårene. Det epidemiologiskeperspektivet på vold har blitt forsterket og et mer etiologisk og preventivt syn på volden er mere merkbarinnenfor sosialmedisinsk forskning. Alkoholen er en etiologisk faktor som har vist seg å være forbundet med voldi de aller fleste samfunn. I denne artikkelen beskrives de viktigste epidemiologiske metodene og funnene i studietav alkoholens sammenheng med vold. Denne sammenhengen har vist seg ikke å være direkte, men er avhengig aven rekke andre faktorer, og noen forskjellige typer av kausal avhengighet beskrives i artikkelen. Den epidemiologiskeforskningen om andre rusmidlers sammenheng med vold er betydelig mindre omfattende enn den er foralkohol. Det er også åpenbart at andre rusmidler ikke er like sterkt sammenknyttet med vold som alkoholen.Pernanen K. Alcohol, other drugs, and violence in an epidemiological perspective.Nor J Epidemiol ENGLISH SUMMARYThe public health approach to violence has become increasingly accepted during the last couple of decades. Thishas led to more epidemiological research into violence, and a stronger medical interest in the etiology and preventionof violence. However, epidemiological research on the prevalence of violence in different societies is stillmainly criminological in nature, being based on information about violence that has come to the attention of thepolice or processed in the courts. The study of the relationship between alcohol use and violent behaviour is alsopredominantly based on police and court materials, although an increasing number of emergency room andhospitalization studies have examined the role of alcohol in injuries caused by violence.There are two basic methodological approaches in the study of the relationship between alcohol use andviolence. The alcohol-involvement studies estimate the extent to which drinking by the offender or the victim

  7. Andres Puustusmaa - mees nagu jalgratas ehk Seitseteist kevadist hetke enne Moskva rongi väljumist / Andres Puustusmaa ; interv. Margus Mikomägi

    Index Scriptorium Estoniae

    Puustusmaa, Andres

    2008-01-01

    Venemaal tegutseva Eestist pärit režissööri Andres Puustusmaa mängufilm "18-14" esilinastub 10. jaanuaril Eestis. Lisaks tõlge filmi tutvustavast tekstist (www.1814.ru) : "Tsarskoje Selo Kõrilõikaja ja lütseumi kasvandikud". Artikkel rubriigis "Teatriküljed 1/25"

  8. Afståelsesret og andre former for lejerskifte

    DEFF Research Database (Denmark)

    Faber, Louise

    Afståelsesret og andre former for lejerskifte indeholder en analyse af lejerens adgang til at overdrage sit lejemål til en ny lejer.  Bogen bygger på forfatterens ph.d. afhandling.  Bogen er opdelt i to dele, en almindelig del, og en speciel del. I bogens almindelige del undersøges spørgsmålet, om...... lejerens ret til lejerskifte, når der ikke er taget stilling i lejeaftalen. Her fastlægges baggrundsretten med udgangspunkt i de obligationsretlige grundsætninger. I denne kontekst beskrives fremlejeretten, lejerens nærtståendes forsættelses- eller overtagelsesret ved lejrens død, skilsmisse m.v., og...... tillige retstillingen når lejeaftalen er indgået med flere lejere, et I/S, et ApS eller et A/S.  I bogens specielle del undersøges lejerens ret til at afstå eller genindtræde lejeforholdet, når lejerens har afståelsesret og genindtrædelsesret ifølge af lejeaftalen. Denne undersøgelse berører udlejerens...

  9. Associations between primary tumor RAS, BRAF and PIK3CA mutation status and metastatic site in patients with chemo-resistant metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Christensen, Troels Dreier; Palshof, Jesper Andreas; Larsen, Finn Ole

    2018-01-01

    investigated the association between RAS (KRAS or NRAS), BRAF, PIK3CA mutations and metastatic pattern in patients with metastatic (m) CRC. MATERIAL AND METHODS: This study reviewed Danish biobank and database of patients with mCRC who received cetuximab and irinotecan, independent of RAS mutation status...

  10. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells.

    Science.gov (United States)

    Pasquier, Benoit

    2015-04-03

    Autophagy plays an important role in cancer and it has been suggested that it functions not only as a tumor suppressor pathway to prevent tumor initiation, but also as a prosurvival pathway that helps tumor cells endure metabolic stress and resist death triggered by chemotherapeutic agents. We recently described the discovery of inhibitors of PIK3C3/Vps34 (phosphatidylinositol 3-kinase, catalytic subunit type 3), the lipid kinase component of the class III phosphatidylinositol 3-kinase (PtdIns3K). This PtdIns3K isoform has attracted significant attention in recent years because of its role in autophagy. Following chemical optimization we identified SAR405, a low molecular mass kinase inhibitor of PIK3C3, highly potent and selective with regard to other lipid and protein kinases. We demonstrated that inhibiting the catalytic activity of PIK3C3 disrupts vesicle trafficking from late endosomes to lysosomes. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Finally our results show that combining SAR405 with everolimus, the FDA-approved MTOR inhibitor, results in a significant synergy on the reduction of cell proliferation using renal tumor cells. This result indicates a potential therapeutic application for PIK3C3 inhibitors in cancer.

  11. Arturo Andrés Roig, lector de Spinoza Arturo Andrés Roig, Spinoza Reader

    Directory of Open Access Journals (Sweden)

    Gerardo Oviedo

    2010-06-01

    Full Text Available La categoría spinoziana de conatus ocupa un puesto central en la arquitectónica discursiva de la filosofía práctica de Arturo Andrés Roig. Se trata de un fundamento previo del saber práctico-moral que oficia de figura explicativa originaria, pues el conatus concierne a una dimensión primaria de los entes. Su status teórico no se reduce por tanto a reconocer un aspecto antropológico entre otros, sino que adquiere un carácter vertebrador en el conjunto de las estrategias de fundamentación de la idea de "moral emergente" propuesta por nuestro filósofo. Nosotros estimamos que la condición ontológica del conatus es una instancia determinante de los planteos éticos y políticos de Arturo Roig. Dicha inflexión spinozista tan patente, sin embargo, no es tenida suficientemente en cuenta en algunas lecturas especializadas de la Argentina. En consecuencia, nos proponemos en primer término destacar la función constructiva que ese momento spinoziano posee en el pensamiento del maestro mendocino, ciñéndonos a un tratamiento de los textos en donde esa fuerza conceptual se torna más visible, sin excluir por cierto otros tratamientos concomitantes. Ello nos permitirá, en un segundo nivel más historiográfico de análisis, revalorar la recepción de Spinoza en los escritos de Arturo Roig.The Spinoza conatus category occupies a central place in the architectural discourse of practical philosophy of Arturo Andres Roig. This is a preliminary basis of practical knowledge and moral figure that offers originating explanation, as the conatus concerns a primary dimension of entities. Its theoretical status is not reduced only to recognizing anthropological aspect among others, but acquires a backbone in the set of strategies to substantiate the idea of "emerging moral" given by our philosopher. We believe that the ontological status is an instance of conatus determinant of ethical and political layout of Arturo Roig. Spinoza said turning so clearly

  12. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

    International Nuclear Information System (INIS)

    Velho, Sérgia; Moutinho, Cátia; Cirnes, Luís; Albuquerque, Cristina; Hamelin, Richard; Schmitt, Fernando; Carneiro, Fátima; Oliveira, Carla; Seruca, Raquel

    2008-01-01

    BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP), MLH1 methylation and microsatellite instability (MSI). We aimed at determine the frequency of KRAS, BRAF and PIK3CA mutations in the process of colorectal tumourigenesis using a series of colorectal polyps and carcinomas. In the series of polyps CIMP, MLH1 methylation and MSI were also studied. Mutation analyses were performed by PCR/sequencing. Bisulfite treated DNA was used to study CIMP and MLH1 methylation. MSI was detected by pentaplex PCR and Genescan analysis of quasimonomorphic mononucleotide repeats. Chi Square test and Fisher's Exact test were used to perform association studies. KRAS, PIK3CA or BRAF occur in 71% of polyps and were mutually exclusive. KRAS mutations occur in 35% of polyps. PIK3CA was found in one of the polyps. V600E BRAF mutations occur in 29% of cases, all of them classified as serrated adenoma. CIMP phenotype occurred in 25% of the polyps and all were mutated for BRAF. MLH1 methylation was not detected and all the polyps were microsatellite stable. The comparison between the frequency of oncogenic mutations in polyps and CRC (MSI and MSS) lead us to demonstrate that KRAS and PIK3CA are likely to precede both types of CRC. BRAF mutations are likely to precede MSI carcinomas since the frequency found in serrated polyps is similar to what is found in MSI CRC (P = 0.9112), but statistically different from what is found in microsatellite stable (MSS) tumours (P = 0.0191). Our results show that BRAF, KRAS and PIK3CA mutations occur prior to malignant transformation demonstrating that these oncogenic alterations are primary genetic events in colorectal carcinogenesis. Further, we show that BRAF mutations occur in association with CIMP phenotype in colorectal serrated polyps and verified that colorectal serrated

  13. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

    Directory of Open Access Journals (Sweden)

    Schmitt Fernando

    2008-09-01

    Full Text Available Abstract Background BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC. In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP, MLH1 methylation and microsatellite instability (MSI. We aimed at determine the frequency of KRAS, BRAF and PIK3CA mutations in the process of colorectal tumourigenesis using a series of colorectal polyps and carcinomas. In the series of polyps CIMP, MLH1 methylation and MSI were also studied. Methods Mutation analyses were performed by PCR/sequencing. Bisulfite treated DNA was used to study CIMP and MLH1 methylation. MSI was detected by pentaplex PCR and Genescan analysis of quasimonomorphic mononucleotide repeats. Chi Square test and Fisher's Exact test were used to perform association studies. Results KRAS, PIK3CA or BRAF occur in 71% of polyps and were mutually exclusive. KRAS mutations occur in 35% of polyps. PIK3CA was found in one of the polyps. V600E BRAF mutations occur in 29% of cases, all of them classified as serrated adenoma. CIMP phenotype occurred in 25% of the polyps and all were mutated for BRAF. MLH1 methylation was not detected and all the polyps were microsatellite stable. The comparison between the frequency of oncogenic mutations in polyps and CRC (MSI and MSS lead us to demonstrate that KRAS and PIK3CA are likely to precede both types of CRC. BRAF mutations are likely to precede MSI carcinomas since the frequency found in serrated polyps is similar to what is found in MSI CRC (P = 0.9112, but statistically different from what is found in microsatellite stable (MSS tumours (P = 0.0191. Conclusion Our results show that BRAF, KRAS and PIK3CA mutations occur prior to malignant transformation demonstrating that these oncogenic alterations are primary genetic events in colorectal carcinogenesis. Further, we show that BRAF mutations occur in association with CIMP phenotype in colorectal

  14. Relative quantification of PIK3CA gene expression level in fine-needle aspiration biopsy thyroid specimens collected from patients with papillary thyroid carcinoma and non-toxic goitre by real-time RT-PCR

    Directory of Open Access Journals (Sweden)

    Wojciechowska-Durczyńska Katarzyna

    2010-08-01

    Full Text Available Abstract Background Recent studies have shown that the phosphatidylinositol 3-kinase (PI3K signaling pathway is important regulator of many cellular events, including apoptosis, proliferation and motility. PI3K pathway alterations (PIK3CA gene mutations and/or amplification have been observed in various human tumours. In the majority of diagnosed cases, mutations are localized in one of the three "hot spots" in the gene, responsible for coding catalytic subunit α of class I PI3K (PIK3CA. Mutations and amplification of PIK3CA gene are characteristic for thyroid cancer, as well. Methods The aim of our study was to examine a gene expression level of PIK3CA in fine-needle aspiration biopsy (FNAB thyroid specimens in two types of thyroid lesions, papillary thyroid carcinoma (PTC and non-toxic goitre (NTG. Following conventional cytological examination, 42 thyroid FNAB specimens, received from patients with PTC (n = 20 and NTG (n = 22, were quantitatively evaluated regarding PIK3CA expression level by real-time PCR in the ABI PRISM® 7500 Sequence Detection System. Results Significantly higher expression level (RQ of PIK3CA in PTC group has been noted in comparison with NTG group (p Conclusion These observations may suggest role of PIK3CA alterations in PTC carcinogenesis.

  15. Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

    International Nuclear Information System (INIS)

    Naguib, Adam; Arends, Mark J; Cooke, James C; Happerfield, Lisa; Kerr, Lucy; Gay, Laura J; Luben, Robert N; Ball, Richard Y; Mitrou, Panagiota N; McTaggart, Alison

    2011-01-01

    The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancers (CRC) and their associations with tumour clinicopathological features, lifestyle factors and dietary consumptions. 186 adenocarcinomas and 16 adenomas from the EPIC Norfolk study were tested for PTEN and PIK3CA mutations by DNA sequencing and PTEN expression changes by immunohistochemistry. Dietary and lifestyle data were collected prospectively using seven day food diaries and lifestyle questionnaires. Mutations in exons 7 and 8 of PTEN were observed in 2.2% of CRC and PTEN loss of expression was identified in 34.9% CRC. Negative PTEN expression was associated with lower blood low-density lipoprotein concentrations (p = 0.05). PIK3CA mutations were observed in 7% of cancers and were more frequent in CRCs in females (p = 0.04). Analysis of dietary intakes demonstrated no link between PTEN expression status and any specific dietary factor. PTEN expression negative, proximal CRC were of more advanced Dukes' stage (p = 0.02) and poor differentiation (p < 0.01). Testing of the prevalence of PIK3CA mutations and loss of PTEN expression demonstrated that these two events were independent (p = 0.55). These data demonstrated the frequent occurrence (34.9%) of PTEN loss of expression in colorectal cancers, for which gene mutations do not appear to be the main cause. Furthermore, dietary factors are not associated with loss of PTEN expression. PTEN expression negative CRC were not homogenous, as proximal cancers were associated with a more advanced Dukes' stage and poor differentiation, whereas distal cancers were associated with earlier Dukes' stage

  16. Ernst Julius Öpik's (1916) note on the theory of explosion cratering on the Moon's surface—The complex case of a long-overlooked benchmark paper

    Science.gov (United States)

    Racki, Grzegorz; Koeberl, Christian; Viik, Tõnu; Jagt-Yazykova, Elena A.; Jagt, John W. M.

    2014-10-01

    High-velocity impact as a common phenomenon in planetary evolution was ignored until well into the twentieth century, mostly because of inadequate understanding of cratering processes. An eight-page note, published in Russian by the young Ernst Julius Öpik, a great Estonian astronomer, was among the key selenological papers, but due to the language barrier, it was barely known and mostly incorrectly cited. This particular paper is here intended to serve as an explanatory supplement to an English translation of Öpik's article, but also to document an early stage in our understanding of cratering. First, we outline the historical-biographical background of this benchmark paper, and second, a comprehensive discussion of its merits is presented, from past and present perspectives alike. In his theoretical research, Öpik analyzed the explosive formation of craters numerically, albeit in a very simple way. For the first time, he approximated relationships among minimal meteorite size, impact energy, and crater diameter; this scaling focused solely on the gravitational energy of excavating the crater (a "useful" working approach). This initial physical model, with a rational mechanical basis, was developed in a series of papers up to 1961. Öpik should certainly be viewed as the founder of the numerical simulation approach in planetary sciences. In addition, the present note also briefly describes Nikolai A. Morozov as a remarkable man, a forgotten Russian scientist and, surprisingly, the true initiator of Öpik's explosive impact theory. In fact, already between 1909 and 1911, Morozov probably was the first to consider conclusively that explosion craters would be circular, bowl-shaped depressions even when formed under different impact angles.

  17. Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas

    Directory of Open Access Journals (Sweden)

    Meagan B. Myers

    2016-04-01

    Full Text Available Mutant cancer subpopulations have the potential to derail durable patient responses to molecularly targeted cancer therapeutics, yet the prevalence and size of such subpopulations are largely unexplored. We employed the sensitive and quantitative Allele-specific Competitive Blocker PCR approach to characterize mutant cancer subpopulations in ductal carcinomas (DCs, examining five specific hotspot point mutations (PIK3CA H1047R, KRAS G12D, KRAS G12V, HRAS G12D, and BRAF V600E. As an approach to aid interpretation of the DC results, the mutations were also quantified in normal breast tissue. Overall, the mutations were prevalent in normal breast and DCs, with 9/9 DCs having measureable levels of at least three of the five mutations. HRAS G12D was significantly increased in DCs as compared to normal breast. The most frequent point mutation reported in DC by DNA sequencing, PIK3CA H1047R, was detected in all normal breast tissue and DC samples and was present at remarkably high levels (mutant fractions of 1.1 × 10−3 to 4.6 × 10−2 in 4/10 normal breast samples. In normal breast tissue samples, PIK3CA mutation levels were positively correlated with age. However, the PIK3CA H1047R mutant fraction distributions for normal breast tissues and DCs were similar. The results suggest PIK3CA H1047R mutant cells have a selective advantage in breast, contribute to breast cancer susceptibility, and drive tumor progression during breast carcinogenesis, even when present as only a subpopulation of tumor cells.

  18. CERN celebrates André Martin’s 80th birthday

    CERN Multimedia

    2009-01-01

    André Martin, pictured at the ceremony held in honour of his 80th birthday. On 27 August 2009 CERN’s Main Auditorium was the venue for a celebration in honour of André Martin’s 80th birthday. Regarded as one of the most important theoretical physicists of his generation, André Martin is one of CERN’s most distinguished figures. The celebration began with a conference, followed by a concert and a reception. After the conference, André Martin made an emotional speech looking back over his fifty-year career and paying tribute to all those who had made important contributions during his time at CERN. "I was extremely happy, and I am very touched by this marvellous celebration you have organised for me. It was a wonderful idea, and I very much enjoyed the concert of Blandine Eynaud and John Devore. My wife, Schu, and I love the music of Gabriel Fauré", he said at the end. André Martin j...

  19. Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant.

    Directory of Open Access Journals (Sweden)

    Paraskevi Gkeka

    2014-10-01

    Full Text Available The PIK3CA gene is one of the most frequently mutated oncogenes in human cancers. It encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα, which activates signaling cascades leading to cell proliferation, survival, and cell growth. The most frequent mutation in PIK3CA is H1047R, which results in enzymatic overactivation. Understanding how the H1047R mutation causes the enhanced activity of the protein in atomic detail is central to developing mutant-specific therapeutics for cancer. To this end, Surface Plasmon Resonance (SPR experiments and Molecular Dynamics (MD simulations were carried out for both wild-type (WT and H1047R mutant proteins. An expanded positive charge distribution on the membrane binding regions of the mutant with respect to the WT protein is observed through MD simulations, which justifies the increased ability of the mutated protein variant to bind to membranes rich in anionic lipids in our SPR experiments. Our results further support an auto-inhibitory role of the C-terminal tail in the WT protein, which is abolished in the mutant protein due to loss of crucial intermolecular interactions. Moreover, Functional Mode Analysis reveals that the H1047R mutation alters the twisting motion of the N-lobe of the kinase domain with respect to the C-lobe and shifts the position of the conserved P-loop residues in the vicinity of the active site. These findings demonstrate the dynamical and structural differences of the two proteins in atomic detail and propose a mechanism of overactivation for the mutant protein. The results may be further utilized for the design of mutant-specific PI3Kα inhibitors that exploit the altered mutant conformation.

  20. Andrés Chiautla, Estado de México

    Directory of Open Access Journals (Sweden)

    J. Tiburcio-Rosales

    2007-01-01

    Full Text Available En el presente trabajo se realizó un Ordenamiento Ecológico Territorial del municipio de San Andrés Chiautla. La metodología empleada fue la propuesta por el INE-SEMARNAP, la cual emplea la variante de los sistemas complejos asociados a la metodología de SEDUE, utilizando las variantes del Levantamiento Fisiográfico realizado a través del SIG para la caracterización de los subsistemas natural y socioeconómico; así como la utilización de los términos de referencia para las transformaciones y permanencias del uso del suelo obtenidos del Programa Estatal de Ordenamiento Territorial elaborado por SEDESOL. Se generaron ocho productos como resultado de la etapa de caracterización del subsistema natural y socioeconómico los cuales son: la calidad ecológica de los recursos naturales, la fragilidad natural, los cambios del uso del suelo y vegetación, la presión de la población sobre su entorno natural, la distribución de la población, los niveles de bienestar de la población, la dinámica espacial y temporal de la población y los aspectos socioeconómicos. Después de la etapa de caracterización se llevó a cabo la integración del subsistema natural para obtener la estabilidad ambiental y las políticas ambientales. Como resultado final se obtuvieron las tablas de uso, políticas y criterios para normalizar la utilización del espacio territorial.

  1. Santo André: Integración de Programas para Promover la Inclusión Social

    OpenAIRE

    Rosana Denaldi

    2003-01-01

    En este trabajo trataremos del programa "Santo André Más Igual", desarrollado desde 1998 en la ciudad de Santo André ubicada en la Región del Gran ABC, en la Región Metropolitana de San Pablo (RMSP) Brasil.

  2. Energy Transition Initiative: Island Energy Snapshot - San Andres and Providencia (Fact Sheet); NREL(National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-03-01

    This profile provides a snapshot of the energy landscape of the Archipelago of San Andres, Providencia, and Santa Catalina (unpopulated), also known as San Andres and Providencia, which is equidistant between Costa Rica and Jamaica and 775 kilometers northwest of Colombia. The archipelago is part of Colombia, though Nicaragua has also laid claim to it.

  3. Shedding Light on the Sea: André Morel's Legacy to Optical Oceanography

    Science.gov (United States)

    Antoine, David; Babin, Marcel; Berthon, Jean-François; Bricaud, Annick; Gentili, Bernard; Loisel, Hubert; Maritorena, Stéphane; Stramski, Dariusz

    2014-01-01

    André Morel (1933-2012) was a prominent pioneer of modern optical oceanography, enabling significant advances in this field. Through his forward thinking and research over more than 40 years, he made key contributions that this field needed to grow and to reach its current status. This article first summarizes his career and then successively covers different aspects of optical oceanography where he made significant contributions, from fundamental work on optical properties of water and particles to global oceanographic applications using satellite ocean color observations. At the end, we share our views on André's legacy to our research field and scientific community.

  4. El patrimonio identitario de la comunidad de San Andrés

    Directory of Open Access Journals (Sweden)

    Carlos Córdova Martínez

    2006-01-01

    Full Text Available La identidad y el patrimonio son elementos recurrentes si se quiere defender la cultura frente a un mundo globalizado. Dicha labor debe realizarse de lo local a lo nacional y viceversa. El trabajo aborda el patrimonio de una pequeña comunidad holguinera, el Consejo Popular de San Andrés, cuyo centro es el poblado homónimo. Con un largo devenir histórico, que se remonta a fines del siglo XVI. San Andrés atesora un rico patrimonio, que puede incluirse fundamentalmente dentro de la cultura campesina.

  5. Pedagogic Juan Andrés Cué Bada's work (1935-1979

    Directory of Open Access Journals (Sweden)

    Janet Reinaldo-Delgado

    2017-06-01

    Full Text Available Juan Andrés Cué Bada was born on November 30, 1908 in the province of Las Tunas. He had an active political participation against Machado and Batista, while he dedicated himself to private education. After the triumph of the Cuban Revolution in 1959 he moved to Santiago de Cuba and in 1962 began his professorial course at the Universidad de Oriente until he died in 1979. Because of the lack of knowledge about his figure and his work as a teacher, this article Intends to explain the pedagogical work of Juan Andrés Cué Bada between the years 1935 and 1979.

  6. Taboo Icons: The Bodily Photography of Andres Serrano

    Directory of Open Access Journals (Sweden)

    Tyler Shine

    2015-08-01

    Full Text Available   Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Verdana;} Andres Serrano’s photography is often dismissed as being shocking for the sake of being shocking. His infamous photograph Piss Christ (1987 is the oft-cited example at the center of the National Endowment for the Arts controversies during the Culture Wars of the 1980s and 1990s. I return to Piss Christ as a way to expand the interpretative scope of Serrano’s early photographs, which I call “taboo icons” because of their ambiguity and ability to crisscross symbolic boundaries in the unstable space between sacred and profane, thus making his images both powerful and potentially dangerous. Building upon previous scholarship that draws connections between modern and early modern aesthetic practices, I look to the material practices of Christianity in medieval Europe characterized by a sophisticated visual culture that mixed both the physical and the spiritual. The intensifying rejection and reverence of matter resulted in divergent responses, yet the contradictory nature of matter remained central to the ideological beliefs of Christianity where the doctrines of Creation, Incarnation, and Resurrection are at its core. Serrano’s visceral photographs are emphatically material and can productively be read vis-à-vis medieval visual culture. In doing so, this reading changes the narrow perception of Serrano’s early photographs and provides an alternative understanding of his artistic project that reinserts religion into contemporary American art discourse.

  7. Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study.

    Science.gov (United States)

    Mirzaa, Ghayda M; Conti, Valerio; Timms, Andrew E; Smyser, Christopher D; Ahmed, Sarah; Carter, Melissa; Barnett, Sarah; Hufnagel, Robert B; Goldstein, Amy; Narumi-Kishimoto, Yoko; Olds, Carissa; Collins, Sarah; Johnston, Kathreen; Deleuze, Jean-François; Nitschké, Patrick; Friend, Kathryn; Harris, Catharine; Goetsch, Allison; Martin, Beth; Boyle, Evan August; Parrini, Elena; Mei, Davide; Tattini, Lorenzo; Slavotinek, Anne; Blair, Ed; Barnett, Christopher; Shendure, Jay; Chelly, Jamel; Dobyns, William B; Guerrini, Renzo

    2015-12-01

    Bilateral perisylvian polymicrogyria (BPP), the most common form of regional polymicrogyria, causes the congenital bilateral perisylvian syndrome, featuring oromotor dysfunction, cognitive impairment, and epilepsy. The causes of BPP are heterogeneous, but only a few genetic causes have been reported. The aim of this study was to identify additional genetic causes of BPP and characterise their frequency in this population. Children (aged ≤18 years) with polymicrogyria were enrolled into our research programme from July, 1980, to October, 2015, at two centres (Florence, Italy, and Seattle, WA, USA). We obtained samples (blood and saliva) throughout this period at both centres and did whole-exome sequencing on DNA from eight trios (two parents and one affected child) with BPP in 2014. After the identification of mosaic PIK3R2 mutations in two of these eight children, we performed targeted screening of PIK3R2 by two methods in a cohort of 118 children with BPP. First, we performed targeted sequencing of the entire PIK3R2 gene by single molecule molecular inversion probes (smMIPs) on 38 patients with BPP with normal to large head size. Second, we did amplicon sequencing of the recurrent PIK3R2 mutation (Gly373Arg) in 80 children with various types of polymicrogyria including BPP. One additional patient had clinical whole-exome sequencing done independently, and was included in this study because of the phenotypic similarity to our cohort. We identified a mosaic mutation (Gly373Arg) in a regulatory subunit of the PI3K-AKT-mTOR pathway, PIK3R2, in two children with BPP. Of the 38 patients with BPP and normal to large head size who underwent targeted next-generation sequencing by smMIPs, we identified constitutional and mosaic PIK3R2 mutations in 17 additional children. In parallel, one patient had the recurrent PIK3R2 mutation identified by clinical whole-exome sequencing. Seven of these 20 patients had BPP alone, and 13 had BPP in association with features of the

  8. André François Boshoff (1945-2016)

    African Journals Online (AJOL)

    Campbell Murn

    National Herbarium in Pretoria and at Stellenbosch. In 1974 André was awarded a. BSc (honours) postgraduate degree in Wildlife Management at the. University of Pretoria (Eugène. Marais. Chair of. Wildlife. Management). It was during this period that he developed a greater interest in birds, especially in their conservation ...

  9. Tõnu Anton kahtlustab linnaisasid omakasu jahtimises / Tõnu Anton, Andres Kõiv, Ando Hagel ; interv. Ulis Guth

    Index Scriptorium Estoniae

    Anton, Tõnu, 1942-

    2004-01-01

    Võru linnavolikogu opositsiooni kuuluv keskerakondlane Tõnu Anton kritiseerib sotsiaalabitalituse ruumide remondirahade kasutamist ja kahtlustab linnavalitsust riigihangete käigus raha kõrvaldamises. Linnapea Ando Hagel ja abilinnapea Andres Kõiv lükkavad süüdistused tagasi

  10. San Andrés: Cotidianidad turística vs. idealismo desarrollista

    Directory of Open Access Journals (Sweden)

    José Ernesto Ramírez

    1988-01-01

    Full Text Available Pragmatic adaptation and idealistic intervention: An analytical description of development agencies within a context of political clientelism in San Andrés Island Colombia. (Tesis de doctorado en desarrollo. University Madison Wisconsin, 1980 Michael Jack Rosherg. University Microfilm Intemational. Ann Arbor, 1982, 301 págs. 6 ils. 40 cuadros.

  11. Andres Ehin tähistas sünnipäeva raamatuesitlusega / Maire Kõrver

    Index Scriptorium Estoniae

    Kõrver, Maire, 1961-

    2006-01-01

    Andres Ehin esitles oma luulekogu "Põdrapõrnikapääsukene" ja selle ingliskeelset tõlget "Moose Beetle Swallow" oma sünnipäeval Iiri suursaadiku residentsis, kus oli kohal ka luulekogu tõlkija, Iiri luuletaja Patrick Cotter

  12. SUTD-i koorik = SUTD Gridshell / Andres Sevtšuk, Raul Kalvo

    Index Scriptorium Estoniae

    Sevtšuk, Andres, 1981-

    2013-01-01

    Singapuri Tehnoloogia ja Disaini Ülikooli (SUTD) raamatukogu paviljon. Eskiis valmis esimese aasta üliõpilastele korraldatud töötoas. Algse ideega töötas edasi City Form Lab (arhitektid Andres Sevtšuk, Raul Kalvo). Paviljon pandi kokku ligi saja üliõpilase osalusel. Valmis: mai 2013

  13. "Riigikogu hoone 90" = "Estonian parliament building 90" / Janno Roos, Andres Labi

    Index Scriptorium Estoniae

    Roos, Janno, 1976-

    2013-01-01

    Eesti Sisearhitektide Liidu 2012. aasta näituse kujunduse preemia pälvinud näitusest (Lossiplats 1A). Kujunduse autorid Janno Roos ja Andres Labi (Ruumilabor). Kuraator Mait Väljas. Graafiline disain: Identity. Sisearhitekti ja ESLi aastapreemiate žürii liikme Mari Kurismaa ning arhitektuuriajaloolase Leele Välja arvamused

  14. Abjeção em textos de André Sant’Anna

    Directory of Open Access Journals (Sweden)

    Leandro Salgueirinho

    2009-07-01

    Full Text Available Trata-se de uma leitura de textos do escritor André Sant’Anna a partir da problematização que, em The Return of the Real (1986, o crítico de arte norte-americano Hal Foster faz da noção de abjeto e da dita abject art.

  15. Andres Herkel : Venemaa esindaja ENPA presidendiks ei sobi / Haldi Ellam, Ravil Khair Al-Din

    Index Scriptorium Estoniae

    Ellam, Haldi

    2007-01-01

    Vene ajalehe Kommersant väitel on Eesti parlamendi süüdistused ENPA presidendi Rene van der Lindeni vastu seotud Mihhail Margelovi võimaliku valimisega uueks presidendiks. Kristiina Ojuland ja Andres Herkel lükkavad väite tagasi

  16. Maramaa elust poksi ja graffitini / Andres Lepik, Ott Aardam ; interv. Gert Kiiler

    Index Scriptorium Estoniae

    Lepik, Andres

    2008-01-01

    Ugala teater alustas 89. hooaega. Esimese poole plaanitud esietendused : Toomas Suumani "Linnapea" Heiki Raudla raamatu "August Maramaa aeg" järgi, lavastaja Andres Lepik. Ott Aardami noortetükist "Poks", lavastaja autor. Gerald Sibleyras' "Grafiti", lavastaja Taago Tubin. Silvia Soro jõulunäidend "Inetu pardipoja" ainetel, lavastaja Oleg Titov

  17. Miocene and Pleistocene mollusks from San Andres Island (Caribbean Sea, Colombia) and Paleogeographic considerations

    International Nuclear Information System (INIS)

    Diaz M, Juan Manuel; Garcia Llano, Cesar Fernando

    2010-01-01

    San Andres Island is the largest emerged portion of the oceanic archipelago of San Andres and Providencia, southwestern Caribbean Sea; it originated as a coralline atoll during Miocene times. The central and highest part of the island consists of a calcareous crest, the San Andres Formation, formed by Neogene lagoonal and reefal deposits. This crest is surrounded by a calcareous platform of Pleistocene age (San Luis Formation) which emerges only along the island coast, whereas its most part is submerged and covered by a Recent reef complex. Fossil material of molluscs from these two formations was collected in various sites throughout the island and taxonomically identified. In the four sites sampled in the San Andres Formation, material belonging to 19 gastropod and 37 bivalve species was obtained, most of them relatively well represented in other geologic formations of the Caribbean region that are stratigraphically situated between the upper Miocene and the middle Pliocene. Some elements occurring in this formation, such as Ostrea haitiensis, Meretrix dariena and Siphocypraea henekeni, were widely distributed in the Caribbean Miocene Province. In the San Luis Formation, material belonging to 18 gastropod and 11 bivalve species was obtained, most of them also represented in the Recent molluscan fauna of the region. The estimated age of this formation is Sangamonian, hence corresponding to similar formations occurring in Grand Cayman, Jamaica, Hispaniola, the Netherlands Antilles and other Caribbean islands, with which it also shows a great similarity in the composition of the molluscan fauna.

  18. Who Is DeAndre? Tapping the Power of Popular Culture in Literacy Learning

    Science.gov (United States)

    Gainer, Jesse

    2008-01-01

    Gainer talks about the importance of connecting students' background knowledge, experiences, and interests to curricular goals. He highlights the voice of DeAndre, an eighth-grade boy in special education classes, whose participation in an after-school club led to the creation of a video. According to Gainer, "[W]hen given the opportunity to…

  19. [Rets. rmt. : Glucksmann, Andre. Ouest contre Ouest. Pariis, 2003] / Malle Talvet

    Index Scriptorium Estoniae

    Talvet, Malle

    2004-01-01

    Prantsuse filosoofi Andre Glucksmanni raamat "Ouest contre Ouest" ehk "Lääs Lääne vastu" käsitleb rahvusvahelisi sündmusi 2002/2003, eelkõige Iraaki, terrorismi, Ameerika Ühendriike ja Prantsusmaad

  20. El naturalista Alejando de Humboldt, Cavanilles y Juan Andrés

    Directory of Open Access Journals (Sweden)

    María-Rosario MARTÍ MARCO

    2009-11-01

    Full Text Available RESUMEN: Tras una breve introducción en la que se traza un paralelismo entre el erudito Juan Andrés y el naturalista Alejandro de Humboldt, se presenta una síntesis de la relevancia del viaje científico de Humboldt iniciado en España. Las referencias sobre la figura y trabajo de Humboldt y, en menor medida, sobre Cavanilles en la gran obra total de Andrés demuestran el vigor intelectual de éste, quien subraya muchos de los elementos fundamentales del legado humboldtiano.ABSTRACT: This paper begins with a brief introduction to the similarities between the scholar Juan Andrés and the naturalist Alexander von Humboldt and continues with a summary of the relevance of Humboldt’s scientific expedition which began in Spain. The references to Humboldt’s persona and endeavours, and to a lesser extent to Cavanilles, in all of Andrés’ great works demonstrate the intellectual ability of the author who pinpoints many of the fundamental aspects of Humboldt’s legacy.

  1. Exploration, Invention and Imagination: The Myth of Icarus in André Bazin

    NARCIS (Netherlands)

    Joret, B.; Viegas, S.; Teixeira, M.T.

    2015-01-01

    In this essay, I intend to elucidate the ontological implications of André Bazin’s integral realism: "a recreation of the world in its own image." The connection that he draws between the world and the image is in harmony with his mythical project for cinema, which argues that an imaginative myth

  2. Giving Voice: Narrating silence, history and memory in André Brink ...

    African Journals Online (AJOL)

    This essay examines André Brink's two most recent novels, The Other Side of Silence (2002) and Before I Forget (2004), in terms of their voicing of silence and the rewriting of history and memory. Each has a theme familiar to Brink's readers – an historical story of colonial violence and violation avenged; and the recounting ...

  3. Baltoscandal on lõppenud, uued mõtted on saadud / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2006-01-01

    Eesti teater oli Baltoscandalil koondatud olematu teatri mõiste alla. Andres Noormetsa "Reunioon", Mart Kangro ja Ansambel U "Mäng", Marco Laimre "Vangistus", Asko Künnapi "Säälpool jõge", Anders Härmi "Cooking and Shitting", Sven Kuntu "Miks Eesti mehed ei tantsi?", Linnar Priimäe "Inimese lõhn"

  4. Perekonnad hoiavad kontrolli tuntud suurfirmade tegevuse üle / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2005-01-01

    Andres Haamer räägib oma perefirma Overall Eesti loomisest. Uniprindi-Unipressi omanikud Sirje ja Andrus Reinsoo hindavad koos oma äri peatrumpideks täielikku usaldust ja teineteisemõistmist. Lisad: Maailma legend: Rockefellerid; Eesti legend: Puhkid

  5. Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern

    Science.gov (United States)

    Al-Shamsi, Humaid O.; Jones, Jeremy; Fahmawi, Yazan; Dahbour, Ibrahim; Tabash, Aziz; Abdel-Wahab, Reham; Abousamra, Ahmed O. S.; Shaw, Kenna R.; Xiao, Lianchun; Hassan, Manal M.; Kipp, Benjamin R.; Kopetz, Scott; Soliman, Amr S.; McWilliams, Robert R.; Wolff, Robert A.

    2016-01-01

    Background The frequency rates of mutations such as KRAS, NRAS, BRAF, and PIK3CA in colorectal cancer (CRC) differ among populations. The aim of this study was to assess mutation frequencies in the Arab population and determine their correlations with certain clinicopathological features. Methods Arab patients from the Arab Gulf region and a population of age- and sex-matched Western patients with CRC whose tumors were evaluated with next-generation sequencing (NGS) were identified and retrospectively reviewed. The mutation rates of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC were recorded, along with clinicopathological features. Other somatic mutation and their rates were also identified. Fisher’s exact test was used to determine the association between mutation status and clinical features. Results A total of 198 cases were identified; 99 Arab patients and 99 Western patients. Fifty-two point seven percent of Arab patients had stage IV disease at initial presentation, 74.2% had left-sided tumors. Eighty-nine point two percent had tubular adenocarcinoma and 10.8% had mucinous adenocarcinoma. The prevalence rates of KRAS, NRAS, BRAF, PIK3CA, TP53, APC, SMAD, FBXW7 mutations in Arab population were 44.4%, 4%, 4%, 13.1%, 52.5%, 27.3%, 2% and 3% respectively. Compared to 48.4%, 4%, 4%, 12.1%, 47.5%, 24.2%, 11.1% and 0% respectively in matched Western population. Associations between these mutations and patient clinicopathological features were not statistically significant. Conclusions This is the first study to report comprehensive hotspot mutations using NGS in Arab patients with CRC. The frequency of KRAS, NRAS, BRAF, TP53, APC and PIK3CA mutations were similar to reported frequencies in Western population except SMAD4 that had a lower frequency and higher frequency of FBXW7 mutation. PMID:28078112

  6. Montage, Militancy, Metaphysics: Chris Marker and André Bazin

    Directory of Open Access Journals (Sweden)

    Sarah Cooper

    2010-01-01

    Full Text Available

     

    Abstract (E: This article focuses on the relationship between the work of André Bazin and Chris Marker from the late 1940s through to the late 1950s and beyond. The division between Bazin's ŘRight Bankř affiliation with Les Cahiers du Cinéma on the one hand, and Markerřs ŘLeft Bankř allegiances on the other, is called into question here as my argument seeks to muddy the waters of their conventional ideological separation across the river Seine. Working alliteratively through Markerřs well-known talent for deft montage along with his militancy, I consider Bazinřs praise for Markerřs editing technique Ŕ in spite of famously expressing a preference elsewhere for the long take, and deep focus cinematography Ŕ and I address their political differences and convergences. Yet I also explore the rather more unexpected question of metaphysics in order to further emphasize a closer relationship between these two figures. I chart the emergence of an enduring spiritual bond between critic and filmmaker that surfaces first in Markerřs writings for the left-wing Catholic journal L’EspritThe Potsdam Parallel Ice Sheet Model (PISM-PIK – Part 2: Dynamic equilibrium simulation of the Antarctic ice sheet

    Directory of Open Access Journals (Sweden)

    M. A. Martin

    2011-09-01

    Full Text Available We present a dynamic equilibrium simulation of the ice sheet-shelf system on Antarctica with the Potsdam Parallel Ice Sheet Model (PISM-PIK. The simulation is initialized with present-day conditions for bed topography and ice thickness and then run to steady state with constant present-day surface mass balance. Surface temperature and sub-shelf basal melt distribution are parameterized. Grounding lines and calving fronts are free to evolve, and their modeled equilibrium state is compared to observational data. A physically-motivated calving law based on horizontal spreading rates allows for realistic calving fronts for various types of shelves. Steady-state dynamics including surface velocity and ice flux are analyzed for whole Antarctica and the Ronne-Filchner and Ross ice shelf areas in particular. The results show that the different flow regimes in sheet and shelves, and the transition zone between them, are captured reasonably well, supporting the approach of superposition of SIA and SSA for the representation of fast motion of grounded ice. This approach also leads to a natural emergence of sliding-dominated flow in stream-like features in this new 3-D marine ice sheet model.

  7. The Potsdam Parallel Ice Sheet Model (PISM-PIK) - Part 2: Dynamic equilibrium simulation of the Antarctic ice sheet

    Science.gov (United States)

    Martin, M. A.; Winkelmann, R.; Haseloff, M.; Albrecht, T.; Bueler, E.; Khroulev, C.; Levermann, A.

    2011-09-01

    We present a dynamic equilibrium simulation of the ice sheet-shelf system on Antarctica with the Potsdam Parallel Ice Sheet Model (PISM-PIK). The simulation is initialized with present-day conditions for bed topography and ice thickness and then run to steady state with constant present-day surface mass balance. Surface temperature and sub-shelf basal melt distribution are parameterized. Grounding lines and calving fronts are free to evolve, and their modeled equilibrium state is compared to observational data. A physically-motivated calving law based on horizontal spreading rates allows for realistic calving fronts for various types of shelves. Steady-state dynamics including surface velocity and ice flux are analyzed for whole Antarctica and the Ronne-Filchner and Ross ice shelf areas in particular. The results show that the different flow regimes in sheet and shelves, and the transition zone between them, are captured reasonably well, supporting the approach of superposition of SIA and SSA for the representation of fast motion of grounded ice. This approach also leads to a natural emergence of sliding-dominated flow in stream-like features in this new 3-D marine ice sheet model.

  8. microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway.

    Science.gov (United States)

    Zhang, Junfeng; Zhang, Zongqi; Zhang, David Y; Zhu, Jianbing; Zhang, Tiantian; Wang, Changqian

    2013-01-01

    Endothelial progenitor cells (EPCs) are capable of proliferating and differentiating into mature endothelial cells, and they have been considered as potential candidates for coronary heart disease therapy. However, the transition of EPCs to mesenchymal cells is not fully understood. This study aimed to explore the role of microRNA 126 (miR-126) in the endothelial-to-mesenchymal transition (EndMT) induced by transforming growth factor beta 1 (TGFβ1). EndMT of rat bone marrow-derived EPCs was induced by TGFβ1 (5 ng/mL) for 7 days. miR-126 expression was depressed in the process of EPC EndMT. The luciferase reporter assay showed that the PI3K regulatory subunit p85 beta (PIK3R2) was a direct target of miR-126 in EPCs. Overexpression of miR-126 by a lentiviral vector (lenti-miR-126) was found to downregulate the mRNA expression of mesenchymal cell markers (α-SMA, sm22-a, and myocardin) and to maintain the mRNA expression of progenitor cell markers (CD34, CD133). In the cellular process of EndMT, there was an increase in the protein expression of PIK3R2 and the nuclear transcription factors FoxO3 and Smad4; PI3K and phosphor-Akt expression decreased, a change that was reversed markedly by overexpression of miR-126. Furthermore, knockdown of PIK3R2 gene expression level showed reversed morphological changes of the EPCs treated with TGFβ1, thereby giving the evidence that PIK3R2 is the target gene of miR-126 during EndMT process. These results show that miR-126 targets PIK3R2 to inhibit EPC EndMT and that this process involves regulation of the PI3K/Akt signalling pathway. miR-126 has the potential to be used as a biomarker for the early diagnosis of intimal hyperplasia in cardiovascular disease and can even be a therapeutic tool for treating cardiovascular diseases mediated by the EndMT process.

  9. microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway.

    Directory of Open Access Journals (Sweden)

    Junfeng Zhang

    Full Text Available AIMS: Endothelial progenitor cells (EPCs are capable of proliferating and differentiating into mature endothelial cells, and they have been considered as potential candidates for coronary heart disease therapy. However, the transition of EPCs to mesenchymal cells is not fully understood. This study aimed to explore the role of microRNA 126 (miR-126 in the endothelial-to-mesenchymal transition (EndMT induced by transforming growth factor beta 1 (TGFβ1. METHODS AND RESULTS: EndMT of rat bone marrow-derived EPCs was induced by TGFβ1 (5 ng/mL for 7 days. miR-126 expression was depressed in the process of EPC EndMT. The luciferase reporter assay showed that the PI3K regulatory subunit p85 beta (PIK3R2 was a direct target of miR-126 in EPCs. Overexpression of miR-126 by a lentiviral vector (lenti-miR-126 was found to downregulate the mRNA expression of mesenchymal cell markers (α-SMA, sm22-a, and myocardin and to maintain the mRNA expression of progenitor cell markers (CD34, CD133. In the cellular process of EndMT, there was an increase in the protein expression of PIK3R2 and the nuclear transcription factors FoxO3 and Smad4; PI3K and phosphor-Akt expression decreased, a change that was reversed markedly by overexpression of miR-126. Furthermore, knockdown of PIK3R2 gene expression level showed reversed morphological changes of the EPCs treated with TGFβ1, thereby giving the evidence that PIK3R2 is the target gene of miR-126 during EndMT process. CONCLUSIONS: These results show that miR-126 targets PIK3R2 to inhibit EPC EndMT and that this process involves regulation of the PI3K/Akt signalling pathway. miR-126 has the potential to be used as a biomarker for the early diagnosis of intimal hyperplasia in cardiovascular disease and can even be a therapeutic tool for treating cardiovascular diseases mediated by the EndMT process.

  10. Characterization of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next generation sequencing study

    Science.gov (United States)

    Mirzaa, Ghayda; Conti, Valerio; Timms, Andrew E.; Smyser, Christopher D.; Ahmed, Sarah; Carter, Melissa; Barnett, Sarah; Hufnagel, Robert B.; Goldstein, Amy; Narumi-Kishimoto, Yoko; Olds, Carissa; Collins, Sarah; Johnston, Kathreen; Deleuze, Jean-François; Nitschké, Patrick; Friend, Kathryn; Harris, Catharine; Goetsch, Allison; Martin, Beth; Boyle, Evan August; Parrini, Elena; Mei, Davide; Tattini, Lorenzo; Slavotinek, Anne; Blair, Ed; Barnett, Christopher; Shendure, Jay; Chelly, Jamel; Dobyns, William B.; Guerrini, Renzo

    2015-01-01

    SUMMARY Background Bilateral perisylvian polymicrogyria (BPP), the most common form of regional polymicrogyria, causes the congenital bilateral perisylvian syndrome, featuring oromotor dysfunction, cognitive impairment and epilepsy. BPP is etiologically heterogeneous, but only a few genetic causes have been reported. The aim of this study was to identify additional genetic etiologies of BPP and delineate their frequency in this patient population. Methods We performed child-parent (trio)-based whole exome sequencing (WES) on eight children with BPP. Following the identification of mosaic PIK3R2 mutations in two of these eight children, we performed targeted screening of PIK3R2 in a cohort of 118 children with BPP who were ascertained from 1980 until 2015 using two methods. First, we performed targeted sequencing of the entire PIK3R2 gene by single molecule molecular inversion probes (smMIPs) on 38 patients with BPP with normal-large head size. Second, we performed amplicon sequencing of the recurrent PIK3R2 mutation (p.Gly373Arg) on 80 children with various types of polymicrogyria including BPP. One additional patient underwent clinical WES independently, and was included in this study given the phenotypic similarity to our cohort. All patients included in this study were children (BPP. Of the 38 patients with BPP and normal-large head size who underwent targeted next generation sequencing by smMIPs, we identified constitutional and mosaic PIK3R2 mutations in 17 additional children. In parallel, one patient was found to have the recurrent PIK3R2 mutation by clinical WES. Seven patients had BPP alone, and 13 had BPP in association with features of the megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH). Nineteen patients had the same mutation (Gly373Arg), and one had a nearby missense mutation (p.Lys376Glu). Across the entire cohort, mutations were constitutional in 12 and mosaic in eight patients. Among mosaic patients, we observed substantial

  11. Europan 7 Eestis : Lasnamäe. Pärnu / Tiit Trummal, Andres Kurg

    Index Scriptorium Estoniae

    Trummal, Tiit, 1954-

    2004-01-01

    Võistluse "Äärelinna võimalus, linnalik intensiivsus ja elamise mitmekesisus" Eesti-Rootsi ühisžüriis Eestist Urmas Muru, Tiit Trummal, Andres Kurg. Tallinna Lasnamäe (14 tööd) ja Pärnu (47 tööd) võistlusalast, võitnud tööde arhitektide loetelu ja võitnud töödest. Lasnamäe: I preemia - autor hispaanlane Andres Fernandes Atela, kaasautorid prantslased Mathieu Andrieu ja Iman Morshedi. Pärnu: I preemia - autorid rumeenlane Oana-Maria Bogdan, ameeriklane Susan Kelly Shannon, argentiinlane Laura Vescina, hispaanlased Juny Llach ja Parra Colacios

  12. Séminaire de probabilités XXXIX in memoriam Paul-André Meyer

    CERN Document Server

    Yor, Marc

    2006-01-01

    The 39th volume of Séminaire de Probabilités is a tribute to the memory of Paul André Meyer. His life and achievements are recalled; homages are rendered by his friends and colleagues. This volume also contains mathematical contributions to classical and quantum stochastic calculus, the theory of processes, martingales and their applications to mathematical finance, Brownian motion. They provide an overview on the current trends of stochastic calculus.

  13. Sexualcoercion: Woman Subordination Undergone By Hanna X In Andre Brink's The Otherside Of Silence Novel

    OpenAIRE

    NUSANTI, RIHAN

    2014-01-01

    Nusanti, Rihan. 2014. “Sexual Coercion: Woman Subordination Undergoneby Hanna X in Andre Brink's The Otherside of Silence novel”. Study Programof English, Department of Languages and Literature, Faculty of Cultural Studies,Universitas Brawijaya. Supervisor: Fariska Pujiyanti, M.Hum; Co-supervisor: Winda Candra Hantari,M.A. Keywords: Feminist-Marxist, sexual coercion, patriarchy, women subordination,German women In traditional view, women occupy secondary position lower than men in society. It...

  14. Analysis of lichen species for atmospheric pollution biomonitoring in the Santo Andre municipality, Sao Paulo, Brazil

    International Nuclear Information System (INIS)

    Saiki, M.; Alves, E.R.; Marcelli, M.P.

    2007-01-01

    Instrumental neutron activation analysis was applied for the determination of trace elements in Canoparmelia texana species collected in nonpolluted areas of Atlantic Forest and in six sites of Santo Andre Municipality, SP, Brazil. Concentrations of As, Ba, Br, Ca, Cd, Cl, Cr, Cs, Co, Fe, K, La, Mn, Na, Rb, Sb, Sc, Se, U, and Zn were determined and comparisons were made between the results obtained in lichens from different sites

  15. André B. Muller (25.9.1918-1.4.2006)

    Science.gov (United States)

    West, R. M.

    2006-06-01

    With great sadness, we have learned about the death of André Muller on 1 April, at the age of 87. Living in retirement in his native Holland since 1983, he was one of ESOs true pioneers, an outstanding representative of the select group of European astronomers who succeeded in steering ESO through the difficult initial phases. André was close-ly associated with the entire process, from the first site monitoring programmes in South Africa to the subsequent search in Chile, the decision in favour of the La Silla site, as well as the management of ESOs early activities in Chile, includ-ing the construction of the headquarters and observatory and the installation of the first generation of ESO telescopes. Few persons, if any, have been so inti-mately connected to the setting-up of ESOs facilities and it would be impossible to list in detail all of the services André performed for the organisation with such great expertise and zeal during his long career.

  16. “O Negro André”: a questão racial na vida e no pensamento do abolicionista André Rebouças

    Directory of Open Access Journals (Sweden)

    Anita Maria Pequeno Soares

    2017-08-01

    Full Text Available The main objective of this work was to analyze how the context of racial relations influenced the construction of the self and the intellectual production of black intellectual and abolitionist André Rebouças. Through primary sources, it was possible to recreate the process of “self construction” lived by André Rebouças as a black man who had African ancestry. It was possible to notice that some characteristics of his social thought became radical at the same time the self-recognition of his racial condition became deeper, during the period in which he was self-exiled from Brazil, immediately after the proclamation of the republic in 1889. During his life in Africa, he broke his silence about his racial reality. In this period, the construction of his self goes through a transformation, as he begins to see himself and to reaffirm himself as a black and African man. This awaken to “racial consciousness” was interpreted, like Mattos suggested (2010, inspired by the concept of “double consciousness”, elaborated by Du Bois and further developed by Paul Gilroy in “The Black Atlantic” (2012.

  17. Origins of the Salado, Seven Rivers, and San Andres salt margins in Texas and New Mexico: Revision 1: Topical report

    International Nuclear Information System (INIS)

    Boyd, S.D.; Murphy, P.J.

    1987-02-01

    The present boundaries of the San Andres, Seven Rivers, and Salado salts generally lie along the periphery of the Palo Duro and Tucumcari Basins. Various geologic mechanisms occurring singularly or in combination determined the positions of the salt margins. These mechanisms include nondeposition of salt and syndepositional and postdepositional dissolution. In New Mexico, San Andres units pinch out against the Pedernal and Sierra Grande Uplifts, indicating that nondeposition established the original salt margins there. Syndepositional dissolution of exposed Upper San Andres salts occurred in response to Guadalupian upwarp of the basin margins. Triassic erosion differentially removed Permian salt-bearing formations along the uplifts. Late Tertiary dissolution is indicated by fill of north-south trending collapse valleys. In Texas, Guadalupian upwarp along the Amarillo Uplift caused pinchout of Units 2 and 3 in the Lower San Andres and influenced the deposition of subsequent salt-bearing strata. The discontinuity of Upper San Andres evaporites across the Amarillo Uplift suggests syndepositional dissolution. Along the eastern and northeastern basin margin, dissolution may have accompanied Triassic erosion of locally uplifted Upper Permian strata. Tertiary dissolution is recognized beneath anomalously thick Ogallala Formation sections that overlie collasped Permian strata. 49 refs., 31 figs., 2 tabs

  18. Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients

    Directory of Open Access Journals (Sweden)

    Silvia N. Kariuki

    2010-01-01

    Full Text Available The PIK3C3 locus was implicated in case-case genome-wide association study of systemic lupus erythematosus (SLE which we had performed to detect genes associated with autoantibodies and serum interferon-alpha (IFN-α. Herein, we examine a PIK3C3 promoter variant (rs3813065/-442 C/T in an independent multiancestral cohort of 478 SLE cases and 522 controls. rs3813065 C was strongly associated with the simultaneous presence of both anti-Ro and anti-Sm antibodies in African-American patients [OR=2.24 (1.34–3.73, P=2.0×10−3]. This autoantibody profile was associated with higher serum IFN-α (P=7.6×10−6. In the HapMap Yoruba population, rs3813065 was associated with differential expression of ERAP2 (P=2.0×10−5, which encodes an enzyme involved in MHC class I peptide processing. Thus, rs3813065 C is associated with a particular autoantibody profile and altered expression of an MHC peptide processing enzyme, suggesting that this variant modulates serologic autoimmunity in African-American SLE patients.

  19. Ecrire à la suite de : Andrée Lacelle, Andrée Christensen et Jacques Flamand, Paul Savoie et Dyane Léger

    Directory of Open Access Journals (Sweden)

    Catherine Parayre

    2012-05-01

    Full Text Available « Ecrire à la suite de » est un procédé d’écriture courant dans la littérature, qu’il s’agisse de mettre en relief l’intertextualité de l’œuvre (par exemple, en incluant des citations, de s’adonner à un travail basé sur l’intermédialité (par exemple, dans un texte rédigé à partir de photographies ou encore d’écrire à quatre mains, lorsqu’un des deux auteurs ajoute son texte à celui du partenaire d’écriture. Ne faisant pas exception, les littératures francophones du Canada pratiquent tout aussi fréquemment cette écriture de l’après. Le présent article en examinera quelques exemples dans des œuvres de nature introspective : La lumière et l’heure : poèmes et carnets (2004 d’Andrée Lacelle, avec des tableaux de Réjine Halimi ; Lithochronos ou le premier vol de la pierre (1999 d’Andrée Christensen et Jacques Flamand, avec des photographies de Christensen ; et L’incendiaire (2008 de Paul Savoie et Dyane Léger. L’analyse montrera que l’écriture « à la suite de », aussi variées qu’en soient les manifestations, non seulement met en évidence la présence de l’auteur dans ces textes, mais a aussi pour résultat, dans ces œuvres méditatives, de dédramatiser et d’amenuiser l’intensité de la réflexion existentielle.

  1. Jacobsens ukendte samling af stensager fra den græske oldtid. Obsidian, økser, matricer, ansigtssten og andre sjældne oldsager

    DEFF Research Database (Denmark)

    Sørensen, Lasse

    2012-01-01

    Jacobsens ukendte samling af stensager fra den græske oldtid. Obsidian, økser, matricer, ansigtssten og andre sjældne oldsager......Jacobsens ukendte samling af stensager fra den græske oldtid. Obsidian, økser, matricer, ansigtssten og andre sjældne oldsager...

  2. Teresa Andrés y la organización Cultura Popular: una propuesta de coordinación bibliotecaria (1936-1938

    Directory of Open Access Journals (Sweden)

    Seguí i Francés, Romà

    2011-12-01

    Full Text Available Teresa Andrés Zamora es conocida por su actividad al frente de la Sección de Bibliotecas de Cultura Popular. Este trabajo describe las relaciones que se establecieron entre Teresa Andrés y Cultura Popular, tras hacerse cargo de las responsabilidades del Ministerio de Instrucción Pública.

  3. Book Review: America’s Blind Spot: Chávez, Oil and US Security by Andrés Cala and Michael Economides

    DEFF Research Database (Denmark)

    Boscan, Luis

    2014-01-01

    Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012.......Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012....

  4. Fromleik i Black Supper, Piss Christ og Crucifixion, tre fotografi av Andres Serrano

    OpenAIRE

    Vinje, Lilly

    2006-01-01

    Oppgåva skal omhandla tre utvalgte foto av fotografen Andres Serrano, ein amerikanar født i 1950. Enkeltbileta det er snakk om er Black Supper (1990), Piss Christ og Crucifixion (begge 1987). Dei er laga ved at kitschfigurar er nedsenka i gjennomsiktige behaldarar fyllte av kroppsvæsker og vatn; vatn i Black Supper, urin i Piss Christ og blod i Crucifixion. Henholdsvis framstiller dei Nattverden, Jesus på krossen og Krossfestinga (tre figurar). Serrano befinn seg med desse innanfor religiøs k...

  5. Harju Elekter väärtustab strateegilist partnerlust / Andres Aarma

    Index Scriptorium Estoniae

    Aarma, Andres

    2003-01-01

    Autor kirjeldab elektriseadmete ja -materjalide tootja, ettevõtte Harju Elekter edu põhjuseid läbi olulisemate strateegiliste juhtimisotsuste, personalijuhtimise, tootmise ning toodangu turustamise. Kommenteerivad Sander Danil, Jako Kotkas, Andres Vainola, Rein Siim ja Triin Palge. Diagrammid: Harju Elektri käive, eksport ja kasum, turud käibe järgi, tegevusalad käibe järgi. Skeemid: Harju Elektri tütar- ja sidusettevõtted, organisatsiooni struktuur. Vt. samas intervjuud Harju Elektri nõukogu esimehe Endel Pallaga; Harju Elektri kontsern täna. Lisad: Harju Elektri olulisemad koostöölepingud, laenude tagatised ja panditud vara

  6. Despedida al maestro Arturo Andrés Roig (1922 – 2012

    Directory of Open Access Journals (Sweden)

    Enrique Dussel

    2015-07-01

    Full Text Available En ocasión del fallecimiento de Arturo Andrés Roig (Doctor Honoris Causa por las Universidades Nacional de Río Cuarto, Argentina; Nacional de San Luis, Argentina; Autónoma de Managua, Nicaragua. Profesor Honorario en las Universidades Nacional del Comahue -Argentina-, y Andina Simón Bolívar -Ecuador- queremos sumarnos a la larga serie de homenajes que ha recibido. Para ello, reproducimos aquí tres memoriales dedicados al maestro por filósofos americanos.

  7. Andres Bello and the Dissemination of Astronomy: Education and Scientific Rhetoric

    Directory of Open Access Journals (Sweden)

    Verónica Ramírez Errázuriz

    2017-12-01

    Full Text Available This paper analyzes the astronomical texts written by Andres Bello between 1810 and 1848, from its educational nature to its rhetorical expression, suggesting that their main purpose was to show the advances in the field - in terms of knowledge production and also technology development- in order to improve the material and intellectual environment of the nation. It also stands that astronomy should be tought by activating creativity and imagination, which may be linked with Bello’s willing to avoid science and art develop apart from each other, keeping, in this case astronomy bonded with literature.

  8. Andre Hellegers and Carroll House: architect and blueprint for the Kennedy Institute of Ethics.

    Science.gov (United States)

    Harvey, John Collins

    2004-06-01

    The Newman programs established at secular colleges and universities provided an opportunity for intellectual, spiritual, and social growth among the Catholic student population. As a young physician and junior medical faculty member, Andre Hellegers took part in the early organization and ongoing work of Carroll House, the Newman Center at the Johns Hopkins Medical Institutions. Helleger's experience at Carroll House enabled him to develop a clear blueprint of an academic center of excellence for the scientific, theological, and philosophical exploration of the many problems that he had seen and foresaw in medicine. That center would become Georgetown's Kennedy Institute of Ethics.

  9. Jovens de Santo André, SP, Brasil: Um estudo sobre valores em diferentes grupos sociais

    OpenAIRE

    Sheila Aparecida Ferreira Lachtim

    2010-01-01

    Esta dissertação se propõe a: apreender valores sociais contemporâneos, notadamente aqueles referidos ao consumo de drogas, discutir diferenças entre esses valores nos diferentes grupos sociais; e analisar possíveis relações entre esses valores. Trata-se de um estudo qualitativo de caráter exploratório, descritivo e analítico que utilizou um roteiro de entrevista semi-estruturada para apreensão do objeto. Um total de 86 jovens participou, de diferentes regiões do município de Santo André, SP,...

  10. Lean versus Quick Response Manufacturing og andre koncepter - er Lean den eneste ene?

    DEFF Research Database (Denmark)

    Michelsen, Aage U

    2005-01-01

    Begrebet Lean har gennem de senere år vundet en enorm udbredelse. Antallet af publikationer om Lean har været eksplosivt stigende, og mange virksomheder har gennemført eller gennemfører Lean-projekter. Er Lean et nyt koncept? Er Lean den eneste løsning? Kan Lean kombineres med tankegange og princ...... løsning af en anden produktionsopgave. I fjerde afsnit skitseres kort relationerne mellem Lean og to andre begreber, Six Sigma og TPM, der begge har samme mål som Lean, men forskellige udgangspunkter og forskellige indfaldsvinkler....

  11. Etnic discrimination and income in San Andrés Island, Colombia

    Directory of Open Access Journals (Sweden)

    Javier Yabrudy

    2011-12-01

    Full Text Available This document examines, bases on the analysis of observable characteristics, if an income gapexists between the raizal population and non raizal population of San Andres Island. For thispurpose, the information of the SISBEN II survey for the year 2004, compelled by the NationalPlanning Department (DNP, Spanish acronym is used. The methodological strategy uses quantileregressions to determine the existence of pay gaps throughout the distribution of income. Theresults suggest that being raizal has a negative impact on income for the lower quantiles. However,this difference vanishes as income increases, becoming positive at higher levels.

  12. APA/APAGS Award for Distinguished Graduate Student in Professional Psychology: Octavio Andres Santos.

    Science.gov (United States)

    2017-12-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded annually by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. The 2017 award winner is Octavio Andres Santos, who has demonstrated through several initiatives "effective engagement with advocacy, professional organizations, and research in the area of health disparities and multicultural/multilingual assessment." Santos's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  13. André Leroi-Gourhan (25 août 1911–19 février 1986)

    OpenAIRE

    Soulier, Philippe

    2007-01-01

    André Leroi-Gourhan (25th August 1911 – 19th February 1986) A short biography of André Leroi-Gourhan is here presented, beginning in 1927, at the moment of his student years, until his retirement in 1982. It rests on a systematic analysis of his publications and on his personal and professional archives, collected and studied for the first time in 2001 when the author was temporally engaged by the CNRS. Going beyond the pure biography of events, such as those already presented in numerous po...

  14. Origen de la surgencia del Balneario de San Andrés (Provincia de Jaén)

    OpenAIRE

    Hidalgo Estévez, Mari Carmen; Rey Arrans, Javier; Redondo, L.

    1997-01-01

    The hydrogeological context of the San Andrés spa (province of Jaén) is analysed in this work. Piezometric data, hydrochemical analysis and groundwater quality trends are discussed for groundwater samples obtained from the main aquifer units in the region (jurassic carbonatic aquifer and miocene detrital aquifer) in order to stablish the origin of the San Andrés spring. Considering altitude, discharge rate, temperature and hydrochemical features of the spring, it seems to be related to the mi...

  15. AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences

    International Nuclear Information System (INIS)

    Dura, Joseph A.; Pierce, Donald J.; Majkrzak, Charles F.; Maliszewskyj, Nicholas C.; McGillivray, Duncan J.; Loesche, Mathias; O'Donovan, Kevin V.; Mihailescu, Mihaela; Perez-Salas, Ursula; Worcester, David L.; White, Stephen H.

    2006-01-01

    An elastic neutron scattering instrument, the advanced neutron diffractometer/reflectometer (AND/R), has recently been commissioned at the National Institute of Standards and Technology Center for Neutron Research. The AND/R is the centerpiece of the Cold Neutrons for Biology and Technology partnership, which is dedicated to the structural characterization of thin films and multilayers of biological interest. The instrument is capable of measuring both specular and nonspecular reflectivity, as well as crystalline or semicrystalline diffraction at wave-vector transfers up to approximately 2.20 A -1 . A detailed description of this flexible instrument and its performance characteristics in various operating modes are given

  16. Statistical zonation technique and its application to the San Andres reservoir in the Poza Rica area, Vera Cruz, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Campa, M F; Romero, M R

    1969-01-01

    A statistical zonation technique developed by J.D. Testerman is presented referring to its application to the San Andres reservoir in the Poza Rica area in Veracruz, Mex. The method is based on a statistical technique which permits grouping of similar values of certain parameter, i.e., porosity, for individual wells within a field. The resulting groups or zones are used in a correlation analysis to deduce whether there is continuity of porosity in any direction. In the San Andres reservoir, there is a continuity of the porous media on NE-SW direction. This is an important fact for the waterflooding project being carried on.

  17. Postsotsialismist vaatemängulinna = From Post-Socialism to the City of the Spectacle / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2007-01-01

    Büroo Alver Trummal Arhitektid töödest, Andres Alverist ja Tiit Trummalist. Ärihoonest Tallinnas Rävala pst. 4. Autorid: Andres Alver, Tiit Trummal, Tarmo Laht, Indrek Rünkla, Ulla Mets, Sven Koppel. Konstruktor Eido Uustalu (Eesti Projekt). Projekt 2001, valmis 2006. City Plazast Tallinnas Tartu mnt. 2. Autorid: A. Alver, T. Trummal, T. Laht, I. Rünkla, Martin Melioranski, U. Mets. Konstruktor: Tiit Masso, Pike Projekt. Sisekujundus (fuajeed, restoran): Pille Lausmäe. Projekt 2001, valmis 2004. Lõige, põhiplaan, 3 värv. välis- ja 5 sisevaadet

  18. Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in ≥ 2 line cetuximab-based therapy of colorectal cancer patients.

    Directory of Open Access Journals (Sweden)

    Zacharenia Saridaki

    2011-01-01

    Full Text Available To investigate the predictive significance of KRAS, BRAF, PIK3CA mutational status, AREG- EREG mRNA expression, PTEN protein expression and skin rash in metastatic colorectal cancer (mCRC patients treated with cetuximab containing salvage chemotherapy.Primary tumors from 112 mCRC patients were analyzed. The worst skin toxicity during treatment was recorded.KRAS, BRAF and PIK3CA mutations were present in 37 (33%, 8 (7.2% and 11 (9.8% cases, respectively, PTEN was lost in 21 (19.8% cases, AREG and EREG were overexpressed in 48 (45% and 51 (49% cases. In the whole study population, time to tumor progression (TTP and overall survival (OS was significantly lower in patients with KRAS (p = 0.001 and p = 0.026, respectively or BRAF (p = 0.001 and p<0.0001, respectively mutant tumors, downregulation of AREG (p = 0.018 and p = 0.013, respectively or EREG (p = 0.002 and p = 0.004, respectively and grade 0-1 skin rash (p<0.0001 and p<0.0001, respectively. In KRAS wt patients TTP and OS was significantly lower in patients with BRAF (p = 0.0001 and p<0.0001, respectively mutant tumors, downregulation of AREG (p = 0.021 and p = 0.004, respectively or EREG (p = 0.0001 and p<0.0001, respectively and grade 0-1 skin rash (p<0.0001 and p<0.0001, respectively. TTP was significantly lower in patients with PIK3CA mutations (p = 0.01 or lost PTEN (p = 0.002. Multivariate analysis revealed KRAS (Hazard Ratio [HR] 4.3, p<0.0001, BRAF mutation (HR: 5.1, p<0.0001, EREG low expression (HR: 1.6, p = 0.021 and absence of severe/moderate skin rash (HR: 4.0, p<0.0001 as independent prognostic factors for decreased TTP. Similarly, KRAS (HR 2.9, p = 0.01, BRAF mutation (HR: 3.0, p = 0.001, EREG low expression (HR: 1.7, p = 0.021, absence of severe/moderate skin rash (HR: 3.7, p<0.0001 and the presence of undifferantited tumours (HR: 2.2, p = 0.001 were revealed as independent prognostic factors for decreased OS.These results underscore that KRAS-BRAF mutations and EREG

  19. La astronomía de un humanista, Juan Andrés

    Directory of Open Access Journals (Sweden)

    José Antonio SANDUVETE CHAVES

    2009-11-01

    Full Text Available RESUMEN: La páginas que siguen pretenden ofrecer una visión de conjunto del análisis que de la historia de la Astronomía realiza Juan Andrés, desde los orígenes de la humanidad hasta el siglo XVIII. Este análisis, incluido en su monumental obra Origen, progresos y estado actual de toda la literatura, destaca por su modernidad y precisión, constituyendo, por tanto, una interesante base de comparación entre la visión de la ciencia astronómica del humanismo ilustrado y la que pervive en la actualidad.ABSTRACT: The following pages attempt to offer a full view of the research into the history of astronomy made by Juan Andrés, from the beginning of human culture until the 18th century. This analysis, included in a broader work called Origen, progresos y estado de toda la literatura, stands out on account of its modern and precise ideas, thus representing an interesting knowledge base for comparing the view of astronomy during the Enlightenment with that of the present.

  20. Convenio "Andres Bello:" Informe Final [de la] Segunda Reunion de Ministros de Educacion de la Region Andina ("Andres Bello" Agreement: Final Report of the Second Meeting of the Andean Region Ministers of Education).

    Science.gov (United States)

    Ministros de Educacion de la Region Andina, Lima (Peru).

    This final report of the second meeting of the Andean Region Ministers of Education subscribing to the Andres Bello Agreement on education and culture contains a resume of the individual sessions and the proposals approved during that meeting. The proposals cover various educational problems and issues and begin with the Declaration of Lima which…

  1. Lineaarse kunstiajaloo aeg on otsas / Edit András ; intervjueerinud R[eet] V[arblane

    Index Scriptorium Estoniae

    András, Edit

    2010-01-01

    Vestlus ungari kunstiteoreetiku- ja ajaloolase Edit Andrásiga, kes osales Tallinnas USA Clarki instituudi ja EKA Kunstiteaduste Instituudi seminaril, kus arutati Kesk- ja Ida-Euroopa kunstiajaloo kirjutamisviiside üle. Seminari tekkimisest, kokkusaamise põhjustest, seminari järeldustest, Eesti ja Ungari kunstiajaloo kirjutamise erinevatest põhimõtetest jm.

  2. Earthworm (Clitellata: Megadrili taxonomy in the last 200 years: A homage to András Zicsi (1928−2015

    Directory of Open Access Journals (Sweden)

    Csuzdi, Cs.

    2016-03-01

    Full Text Available Prof. Dr. András Zicsi, the renowned soil biologist and earthworm taxonomist passed away on 22 July, 2015 at the age of 87. To honour his enormous contribution in exploring earthworm biodiversity all over the world, we provide a brief, albeit subjective overview of the history of earthworm taxonomy in the last two century.

  3. The epidemiology and transmissibility of Zika virus in Girardot and San Andres island, Colombia, September 2015 to January 2016

    Science.gov (United States)

    Rojas, DP; Dean, NE; Yang, Y; Kenah, E; Quintero, J; Tomasi, S; Ramirez, EL; Kelly, Y; Castro, C; Carrasquilla, G; Halloran, ME; Longini, IM

    2016-01-01

    Transmission of Zika virus (ZIKV) was first detected in Colombia in September 2015. As of April 2016, Colombia had reported over 65,000 cases of Zika virus disease (ZVD). We analysed daily surveillance data of ZVD cases reported to the health authorities of San Andres and Girardot, Colombia, between September 2015 and January 2016. ZVD was laboratory-confirmed by reverse transcription-polymerase chain reaction (RT-PCR) in the serum of acute cases within five days of symptom onset. We use daily incidence data to estimate the basic reproductive number (R0) in each population. We identified 928 and 1,936 reported ZVD cases from San Andres and Girardot, respectively. The overall attack rate for reported ZVD was 12.13 cases per 1,000 residents of San Andres and 18.43 cases per 1,000 residents of Girardot. Attack rates were significantly higher in females in both municipalities (p < 0.001). Cases occurred in all age groups with highest rates in 20 to 49 year-olds. The estimated R0 for the Zika outbreak was 1.41 (95% confidence interval (CI): 1.15–1.74) in San Andres and 4.61 (95% CI: 4.11–5.16) in Girardot. Transmission of ZIKV is ongoing in the Americas. The estimated R0 from Colombia supports the observed rapid spread. PMID:27452806

  4. Mis juhtus Andres Lapeteusega? : error'ist kõrgklassi homo soveticus'e näitel / Liisa Kaljula

    Index Scriptorium Estoniae

    Kaljula, Liisa, 1982-

    2014-01-01

    Autor analüüsib 2014. a. Tallinna Semiosalongi loengute sarja põhiteema - error'i mõiste avamiseks ühe inimliigi kujunemislugu - Eesti filmiklassikast tuntud tegelaskuju Andres Lapeteuse tõusu ning langust homo soveticus'ena

  5. Esimene Eesti maja Hiinas = The first Estonian house in China / Andres Põime, Lauri Vaimel ; interv. Triin Ojari

    Index Scriptorium Estoniae

    Põime, Andres

    2008-01-01

    Vestlus Pekingi Eesti saatkonna arhitektuurikonkursi võidutöö autoritega. Tulemused: I preemia - Andres Põime, Lauri Vaimel, II - Erik Nobel, Christian Jensen, Kristen Herup Sovang, Soren Andersson, Pille Kivihall, Dan Ljungar, Hans Willadsen (Taani), III - Kalle Vellevoog, Velle Kadalipp, Tiiu Truus, Martin Prommik

  6. Carlos Hugo Molina Saucedo. Andrés Ibáñez, un caudillo para el siglo XXI. La Comuna de Santa Cruz de la Sierra de 1876; Andrey Schelchkov. Andrés Ibáñez y la Revolución de la Igualdad en Santa Cruz: primer ensayo de federalismo en Bolivia, 1876-1877

    Directory of Open Access Journals (Sweden)

    Clayton Mendonça Cunha Filho

    2014-11-01

    Full Text Available Carlos Hugo Molina Saucedo. Andrés Ibáñez, un caudillo para el siglo XXI. La Comuna de Santa Cruz de la Sierra de 1876Andrey Schelchkov. Andrés Ibáñez y la Revolución de la Igualdad en Santa Cruz: primer ensayo de federalismo en Bolivia, 1876-1877

  7. Aspect of the Characters from The Counterfeiters of André Gide

    Directory of Open Access Journals (Sweden)

    Hülya Kol

    2017-07-01

    Full Text Available As a pastry chef, the writer André Gide kneads his dough differently with the intention of putting an end to imitation in the world of the novel. He has the courage to treat the subject of the novel on the contrary to his contemporaries. He succeeds by introducing the reader into the novel. The reader finds fantastic stories and interesting characters in The Counterfeiters. Themes such as the hypocrisy and falsity of these characters are a reflection of the title that evokes them. Gide transmits this problematic period to the reader with surprising skill. The contrast in the words and behaviors of people are the evil traces of war.

  8. Tecnologias digitais: reflexões sobre usos e excessos ilustradas pelos quadrinhos de Andre Dahmer

    Directory of Open Access Journals (Sweden)

    Janaina Cabello

    2015-12-01

    Full Text Available This paper proposes some reflections about possible crossings/impacts on subjective processes from the appropriation of digital technologies in the twenty-first century and how their uses and (alleged excesses have impacted on the subjective constitutions facing other ways humans can show/look/feel/teach, that constitutes the established relationships in the network society. From a historical and cultural perspective, we discuss about the appropriation of digital technologies and the constitutions of subjectivity (individual and in a wider social context, with the backdrop of the illustrations of the Brazilian cartoonist Andre Dahmer, who, through social networks, discloses his work, which provokes and invites us to think about how we relate and therefore, we show and look at ourselves, feel, teach and learn in new subjective configurations with are crossed, constituted and reconstituted by the appropriation of technologies in the contemporary scene.

  9. New Trends in Approximation Theory : in Memory of André Boivin

    CERN Document Server

    Manolaki, Myrto; Gauthier, Paul

    2018-01-01

    The international conference entitled "New Trends in Approximation Theory" was held at the Fields Institute, in Toronto, from July 25 until July 29, 2016. The conference was fondly dedicated to the memory of our unique friend and colleague, André Boivin, who gave tireless service in Canada until his very last moment of his life in October 2014. The impact of his warm personality and his fine work on Complex Approximation Theory was reflected by the mathematical excellence and the wide research range of the 37 participants. In total there were 27 talks, delivered by well-established mathematicians and young researchers. In particular, 19 invited lectures were delivered by leading experts of the field, from 8 different countries. The wide variety of presentations composed a mosaic of aspects of approximation theory, highlighting interesting connections with important contemporary areas of Analysis. Primary topics discussed include application of approximation theory (isoperimetric inequalities, construction of...

  10. André Gide au miroir de la critique : "Corydon" entre œuvre et manifeste

    OpenAIRE

    Abdallah El Sokati , Chahira

    2011-01-01

    Corydon est un essai dans lequel André Gide soutient une nouvelle théorie de l'amour"pédérastique normal". Il y défend sa position tout en esquissant son identité, et en s'efforçantde faire reconnaître celle-ci à travers son oeuvre. Il répond ainsi à l'inquiétude de toute sagénération, ou au moins d'une élite de cette génération. Gide le dit : Corydon est un livre parlequel il veut " gêner ".La thèse suit les transformations de la réception de Corydon depuis sa publication et étudie lesdiffér...

  11. A propósito de don Andrés Bello

    Directory of Open Access Journals (Sweden)

    Carlos Restrepo Canal

    1965-09-01

    Full Text Available Al meditar en estos días sobre el insigne personaje de quien se conmemora el centenario de su fallecimiento -esto es de don Andrés Bello- al analizar su personalidad, estudiada y elogiada por tan autorizados y eruditos escritor es colombianos y extranjeros, al abrir de nuevo los muchos libros que contien en el variado conjunto de sus obras, se llega al convencimiento de que fue Bello como uno de aquellos grandes y brillantes varones del Renacimiento cuyas amplias facultades les hacían aptos para llegar al conocimiento de múltiples y variadas ramas del saber humano y para profundizar en ellas hasta llegar a constituirse en maestros y guías de las generaciones de su tiempo y de las que les sucedieron.

  12. Bioseguridad y armas biológicas:\tLa amenaza de Andrómeda (1971

    Directory of Open Access Journals (Sweden)

    Manuel SÁNCHEZ

    2016-11-01

    Full Text Available La amenaza de Andrómeda es la adaptación cinematográfica de la obra homónima escrita por Michael Crichton. Puede considerarse como la película más “microbiológica” del Séptimo Arte. Dirigida por Robert Wise, este tecno-thriller describe los esfuerzos de un equipo de científicos para caracterizar y contener a un microorganismo patógeno extraterrestre. A pesar de haber sido realizada hace 40 años, se tratan temas de plena actualidad como es el de las armas biológicas, las medidas de aislamiento y protección, la automatización en los procedimientos sanitarios y la toma de decisiones ante una situación grave e inesperada.

  13. The interior capture of life. Le Corbusier and André Malraux

    Directory of Open Access Journals (Sweden)

    Ana Sofía Pereira da Silva

    2016-05-01

    Writings from both authors and architectural projects from Le Corbusier –  Mundial Museum, Mundaneum and Museum of Unlimited Growth- will be observed in order to map the existent affinities between the two authors. However, life’s pragmatic circumstances often oppose what uses to be in accordance. André Malraux’s classification of the Villa Savoye, while he was  Minister of the Cultural Affairs, aimed to save one of Le Corbusier’s  masterpieces. Nevertheless, this action banned the architect the possibility to transform the Villa Savoye into a new program (in a first approach and, finally, excluded him the possibility of authorship of the rehabilitation project, which was subsequently entrusted to an architect working in the National Monuments bureau. This suspected moment of friction between the two authors shall be motive of observation.

  14. Denissen (Frans), André Baillon. Le gigolo d’Irma Idéal

    OpenAIRE

    Gnocchi, Maria Chiara

    2012-01-01

    Un titre aux résonances insolites vient chatouiller la règle sobre des Archives du Futur, la collection publiée sous la responsabilité des Archives et Musée de la Littérature de Bruxelles. André Baillon. Le gigolo d’Irma Idéal : un titre qui convient bien à une biographie que l’on a déjà — à juste titre — qualifiée d’extra-ordinaire (F. Ghysen, Le Carnet et les Instants, novembre 1998). Extra-ordinaire est d’ailleurs, avant tout, le protagoniste du volume : Baillon le grand écrivain, Baillon ...

  15. Edouard Andre (1840-1911, Jardinero-Naturalista y sus viajes por Colombia y el Ecuador

    Directory of Open Access Journals (Sweden)

    Chardon Carlos E.

    1947-06-01

    Full Text Available En la literatura botánica de Colombia y el Ecuador figura ocasionalmente con tono de notable indiferencia el nombre de EDOUARD ANDRÉ, célebre jardinero-naturalista francés, que visitó estos dos países allá por los años de 1875-1876. Por esta razón, los datos biográficos que se incluyen a continuación pueden ser de interés. Los debo principalmente a la exquisita gentileza de MADAME DUPRAT, bibliotecaria del Museo Nacional de Historia Natural, de París, quien recientemente me ha suministrado copia de los datos biográficos de ANDRE, publicados en la Revue horticote (numero del 1o de noviembre de 1911, agotado.

  16. Ehitatud võrdsus. Tüüpprojekteerimine 20. sajandi elamuehituses : 23. september - 29. oktoober, Eesti Arhitektuurimuuseum, Rotermanni soolaladu / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2000-01-01

    Näitus keskendub linnakorteritele ja -elamutele Eestis, alates 1920. aastate riikliku ehituslaenuga ehitatud korteritest, lõpetades nõukogude perioodi industriaalse massehitusega. Kuraator Andres Kurg, kujundaja arhitektuuribüroo Kolm Pluss Üks

  17. Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis

    International Nuclear Information System (INIS)

    Chen, Jie-Ying; Cheng, Ya-Nan; Han, Lei; Wei, Feng; Yu, Wen-Wen; Zhang, Xin-Wei; Cao, Shui; Yu, Jin-Pu

    2015-01-01

    A meta-analysis was performed to augment the insufficient data on the impact of mutative EGFR downstream phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways on the clinical efficiency of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment of non-small cell lung cancer (NSCLC) patients. Network databases were explored in April, 2015. Papers that investigated the clinical outcomes of NSCLC patients treated with EGFR-TKIs according to the status of K-ras and/or PIK3CA gene mutation were included. A quantitative meta-analysis was conducted using standard statistical methods. Odds ratios (ORs) for objective response rate (ORR) and hazard ratios (HRs) for progression-free survival (PFS) and overall survival (OS) were calculated. Mutation in K-ras significantly predicted poor ORR [OR =0.22; 95% confidence interval (CI), 0.13-0.35], shorter PFS (HR =1.56; 95% CI, 1.27-1.92), and shorter OS (HR =1.59; 95% CI, 1.33-1.91) in NSCLC patients treated with EGFR-TKIs. Mutant PIK3CA significantly predicted shorter OS (HR =1.83; 95% CI, 1.05-3.20), showed poor ORR (OR =0.70; 95% CI, 0.22-2.18), and shorter PFS (HR =1.79; 95% CI, 0.91-3.53) in NSCLC patients treated with EGFR-TKIs. K-ras mutation adversely affected the clinical response and survival of NSCLC patients treated with EGFR-TKIs. PIK3CA mutation showed similar trends. In addition to EGFR, adding K-ras and PIK3CA as routine gene biomarkers in clinical genetic analysis is valuable to optimize the effectiveness of EGFR-TKI regimens and identify optimal patients who will benefit from EGFR-TKI treatment

  18. Geología y aspectos geográficos de la isla de san andrés, colombia

    OpenAIRE

    Vargas Cuervo, German

    2012-01-01

    La Isla de San Andrés ha sido definida geológicamente por varios autores en dos unidades calcáreas de características bien marcadas: Una unidad de calizas heterogéneas,denominada como Formación San Andrés de edad Mioceno y una unidad de calizas coralinas de edad Pleistoceno, conocida como Formación San Luis. La primera unidad aflora en la parte central de la isla y representa la zona de colinas suaves con alturas máximas de 87 m.s.n.m y la Formación San Luis constituye la región plana a suave...

  19. Hotell 'Bernhard' Otepääl. Otepää aedlinn, Kolga tee 22a / Andres Lunge

    Index Scriptorium Estoniae

    Lunge, Andres

    1998-01-01

    Otepää aedlinnas asuva U. Tiirmaa poolt kuuekümnendatel projekteeritud Tartu Katseremonditehase puhkebaasi rekonstrueerimine. Kavandati uus peasissepääs, täiendav tubadekorrus, restoran, vastuvõtufuajee jm. ning juurdeehitusena osaliselt maaalune lisakorpus konverentsisaali jm. ruumidega. Tellija: AS Regel. Projekteerija: Tareke Projekt OÜ. Arhitekt Andres Lunge. Sisekujundaja Taisi Kadarik. Ehitus: AS Regel, 1996-1998. Projekt 1995, 1998, valmis 1998

  20. Distribution and infestation levels of Crypticerya multicicatrices Kondo and Unruh (Hemiptera: Monophlebidae on San Andrés island

    Directory of Open Access Journals (Sweden)

    Takumasa Kondo Kondo

    2014-01-01

    Full Text Available The fluted scale Crypticerya multicicatrices (Hemiptera: Monophlebidae is an invasive insect that became a major pest on the island of San Andrés. To generate control strategies for this insect, its distribution and infestation levels on palm species, fruit trees, leguminous trees and other plant species were determined during January 14–18, 2013. A total of 96 points were sampled in order to determine the distribution of the insect on the island. During the study, the fluted scale was found distributed throughout the island of San Andrés, including Haynes Cay and Johnny Cay. The palms were the plants with the highest levels of infestation, 70.8% had some degree of infestation (37.5% high infestation levels; followed by fruit trees which had 65.6% with some degree of infestation (30.2% high infestation levels; followed by leguminous trees which had 59.6% with some degree of infestation (13.5% high infestation levels and finally “other hosts” which had 51.1% with some level of infestation (11.5% high infestation levels. This study is the first detailed mapping of C. multicicatrices on the island of San Andrés which will become the basis for future work on the population dynamics of the fluted scale and its distribution on the island.

  1. The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.

    Directory of Open Access Journals (Sweden)

    Jatin Roper

    Full Text Available To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type colorectal cancer (CRC.PIK3CA mutant and wild-type human CRC cell lines were treated in vitro with NVP-BEZ235, and the resulting effects on proliferation, apoptosis, and signaling were assessed. Colonic tumors from a genetically engineered mouse (GEM model for sporadic wild-type PIK3CA CRC were treated in vivo with NVP-BEZ235. The resulting effects on macroscopic tumor growth/regression, proliferation, apoptosis, angiogenesis, and signaling were examined.In vitro treatment of CRC cell lines with NVP-BEZ235 resulted in transient PI3K blockade, sustained decreases in mTORC1/mTORC2 signaling, and a corresponding decrease in cell viability (median IC(50 = 9.0-14.3 nM. Similar effects were seen in paired isogenic CRC cell lines that differed only in the presence or absence of an activating PIK3CA mutant allele. In vivo treatment of colonic tumor-bearing mice with NVP-BEZ235 resulted in transient PI3K inhibition and sustained blockade of mTORC1/mTORC2 signaling. Longitudinal tumor surveillance by optical colonoscopy demonstrated a 97% increase in tumor size in control mice (p = 0.01 vs. a 43% decrease (p = 0.008 in treated mice. Ex vivo analysis of the NVP-BEZ235-treated tumors demonstrated a 56% decrease in proliferation (p = 0.003, no effects on apoptosis, and a 75% reduction in angiogenesis (p = 0.013.These studies provide the preclinical rationale for studies examining the efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type CRC.

  2. Puentes de Saint-André-de-Cubzac y de Angers Francia

    Directory of Open Access Journals (Sweden)

    Mathivat, J.

    1978-02-01

    Full Text Available The development of the technique of prefabricated voussoir bridges during the past years has been made possible by the progress achieved in various fields which are developed here, namely: 1 the improvement of the joint between arch stones by the adoption of multiplenotch joints where the adhesive plays a less important part, 2 the increase ín the cross dimensions of the voussoirs as well as in their unit weight, which reduces the number of joints, as well as the diversification of the forms, which can lead to the elimination of the cross prestress, 3 the improvement of the methods of placing and of the design of the lifting rigs: mobile lifting equipement carried by the deck, launching girder. The study of these different factors is supplemented and illustrated by the presentation of two recent works: the freeway bridges of Saint-André-de-Cubzac and the bridge on the Loire near Angers.

    El desarrollo de la técnica de los puentes de dovelas prefabricadas ha experimentado un fuerte incremento, durante los últimos años, a causa de: 1 Mejoramiento de las juntas entre dovelas, por adopción de sistemas dotados de dentado múltiple, en cuyo caso el papel de la cola es menos primordial. 2 Aumento de las dimensiones transversales de las dovelas, así como de su peso unitario, lo cual reduce el número de juntas, así como la diversificación de las formas, con lo cual se puede conseguir la supresión del pretensado transversal. 3 Mejoras introducidas en los métodos de colocación y en el diseño de los aparatos de elevación: equipo móvil de elevación soportado por el propio tablero, viga de lanzamiento. El estudio de estos distintos factores se ha ilustrado con la presentación de dos obras recientemente ejecutadas, a saber: los puentes de autopista de Saint-André-de-Cubzac y el puente del Loira, cerca de Angers.

  3. Drive-induced delocalization in the Aubry-André model

    Science.gov (United States)

    Ray, S.; Ghosh, A.; Sinha, S.

    2018-01-01

    Motivated by the recent experiment by Bordia et al. [Nat. Phys. 13, 460 (2017), 10.1038/nphys4020], we study the single particle delocalization phenomena of the Aubry-André (AA) model subjected to periodic drives. In two distinct cases we construct an equivalent classical description to illustrate that the drive-induced delocalization phenomena stems from an instability and the onset of chaos in the underlying dynamics. In the first case we analyze the delocalization and the thermalization in a time modulated AA potential with respect to driving frequency and demonstrate that there exists a threshold value of the amplitude of the drive. In the next example, we show that the periodic modulation of the phase of the hopping amplitude induced by a gauge field leads to an unusual effect on delocalization with a nonmonotonic dependence on the driving frequency. Within a window of such a driving frequency a delocalized Floquet band with a mobility edge appears, exhibiting multifractality in the spectrum as well as in the Floquet eigenfunctions. Finally, we explore the effect of interaction and discuss how the results of the present analysis can be tested experimentally.

  4. La conquista interior de la vida. Le Corbusier y André Malraux

    Directory of Open Access Journals (Sweden)

    Ana Sofía Pereira da Silva

    2016-05-01

    Escritos de ambos autores y algunas obras de Le Corbusier –Museo Mundial del Mundaneum y Museo de Crecimiento Ilimitado– serán observados con el sentido de mapear las afinidades existentes entre los dos autores. Sin embargo, las circunstancias pragmáticas de la vida a  menudo se entrometen oponiendo lo que suele estar en consonancia. La clasificación de monumento histórico atribuida por André Malraux a la Villa Savoye, mientras fuera Ministro de los Asuntos Culturales, es presentada con la intuición de salvar una de las obras maestras de Le Corbusier. Sin embargo, esta acción terminó impidiendo al arquitecto encontrar en la degradación de la Villa Savoye un pretexto para su transformación, en una primera fase, vetándole también, finalmente, el proyecto de la  restauración de la casa, que es confiada a un arquitecto de los Monumentos Nacionales.2 Este momento intuido de fricción entre los dos  autores será motivo de observación, no arriesgando la evidente afinidad entre los dos.

  5. Chemical Profile and Antioxidant Activity of the Oil from Peony Seeds (Paeonia suffruticosa Andr.

    Directory of Open Access Journals (Sweden)

    Xin Yang

    2017-01-01

    Full Text Available Peony seed oil (PSO is a novel vegetable oil developed from the seeds of Paeonia suffruticosa Andr. The present study aimed to make an overall investigation on the chemical profile and antioxidant activities of PSO for reasonable development and utilization of this new resource food. Chemical analysis revealed that PSO was characterized by an uncommon high portion of α-linolenic acid (>38%, fairly low ratio of n-6 to n-3 polyunsaturated fatty acids (0.69, and much higher content of γ-tocopherol than various conventional seed oils. In vitro assay indicated that PSO is a more potent scavenger of free radicals than extra virgin olive oil. Moderate intake of PSO exhibited obvious protection against various oxidative damages such as tetrachloromethane-induced acute liver injury in mice and diet-induced hyperlipidemia in rats. The changes in the key indicators of oxidative injury and fatty acid composition in the liver caused by PSO administration were measured, and the results demonstrated that antioxidant properties of PSO are closely related to their characteristic chemical composition. Consequently, the present study provided new evidence for the health implications of PSO, which deserves further development for medical and nutritional use against oxidative damages that are associated with various diseases.

  6. Karl Andrée (1880-1959) sedimentologist and marine geologist

    Science.gov (United States)

    Dullo, Wolf-Christian; Pfaffl, Fritz A.

    2017-09-01

    Karl Andrée began studying questions of sedimentology and oceanography in 1908 when working as an assistant at the University of Marburg and he remained faithful to these subjects until his death in 1959. The vast majority of his scientific contributions, however, were published during his time at the University of Königsberg (1915-1945). There he published his fundamental papers on marine geology, all of which adhered strictly to the principles of uniformitarianism, and helped improve our understanding of sedimentary processes and the stratigraphic record. His scientific work has enormous breadth. In the course of 55 years, he published 124 individual papers and books, some of which became classic textbooks. His versatility is particularly evident in his book "Geology of the Seafloor", which contains many pertinent observations and descriptions still relevant today, even if it has fallen out of fashion. This scientist and university teacher was the first to successfully present the huge field of marine geology in all its facet and to consider the deposition of marine sediments as a function of their geographical distribution.

  7. san Andrés, Pinar del Río, Cuba

    Directory of Open Access Journals (Sweden)

    N. Valdés-Rodriguez

    2006-01-01

    Full Text Available El presente trabajo se realizó en la Unidad Forestal San Andrés, en el área que corresponde a las alturas de pizarras, tuvo como objetivo realizar una valoración de diferentes aspectos de su morfología y el endemismo de las especies de plantas leñosas acompañantes en los ecosistemas de pinares naturales presentes en esa zona. Para realizar esta valoración se tomaron en cuenta aspectos como el tipo biológico, la textura de la hoja, el tamaño de la planta, la distribución de la especie y la familia de las especies recolectadas en las zonas de muestreo. Se llegó a la conclusión de que la vegetación acompañante se caracteriza por ser especies de pequeño a mediano tamaño, con hojas medianamente pequeñas, y que no existe entre estas especies ninguna endémica a nivel de distrito o local.

  8. San Andres, Providence and Santa Catalina: a challenge of sustainable development

    International Nuclear Information System (INIS)

    Rodriguez S, Liliana

    2003-01-01

    Satisfactorily to implement the postulates of Biosphere Reserve Sea flower in the Archipelago of San Andres, Providencia and Santa Catalina demands to conjugate national, regional and local efforts in order to surpass the complex economic and social situation untied in this zone of the country after the loss of competitiveness and benefits that the model of Free Port meant to him from 1953 and which they have let perceive itself from principles of the Nineties when Colombia adopted the economic opening like development policy, changes that have resulted in the deterioration of the natural resources and the atmosphere of the islands and finally in the quality of life of their inhabitants and that imposes to this zone of the national territory the challenge to reach the balance man-nature that implies the concept of Biosphere Reserve, category acquired by the Archipelago before UNESCO in the 2000 The absence of agreed economic model with geographic, space, social, cultural and environmental conditions of the Archipelago, together with factors like: (i) political national that does not know the particularities and specificities of this zone of the country, (ii) inter institutional lack of joint in the different levels from the public administration which they concur there, (iii) absence of operation of the Gobernacion Departamental like administrator of the regional public management, (IV) absence of effectiveness population policy to control their indiscriminate increase and (v) lack of social conscience of inhabitants as visitors of the islands with respect to the adapted use of their natural resources and its constitutional and legal obligations to participate in the management like executors or veedors, among other aspects, jeopardizes their development in order to reach the environmental sustainability

  9. Numerical Methods in Atmospheric and Oceanic Modelling: The Andre J. Robert Memorial Volume

    Science.gov (United States)

    Rosmond, Tom

    Most people, even including some in the scientific community, do not realize how much the weather forecasts they use to guide the activities of their daily lives depend on very complex mathematics and numerical methods that are the basis of modern numerical weather prediction (NWP). André Robert (1929-1993), to whom Numerical Methods in Atmospheric and Oceanic Modelling is dedicated, had a career that contributed greatly to the growth of NWP and the role that the atmospheric computer models of NWP play in our society. There are probably no NWP models running anywhere in the world today that do not use numerical methods introduced by Robert, and those of us who work with and use these models everyday are indebted to him.The first two chapters of the volume are chronicles of Robert's life and career. The first is a 1987 interview by Harold Ritchie, one of Robert's many proteges and colleagues at the Canadian Atmospheric Environment Service. The interview traces Robert's life from his birth in New York to French Canadian parents, to his emigration to Quebec at an early age, his education and early employment, and his rise in stature as one of the preeminent research meteorologists of our time. An amusing anecdote he relates is his impression of weather forecasts while he was considering his first job as a meteorologist in the early 1950s. A newspaper of the time placed the weather forecast and daily horoscope side by side, and Robert regarded each to have a similar scientific basis. Thankfully he soon realized there was a difference between the two, and his subsequent career certainly confirmed the distinction.

  10. Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.

    Directory of Open Access Journals (Sweden)

    Douglas D Fang

    Full Text Available PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide mutations can help predict the antitumor activity of phosphatidylinositol-3-kinase (PI3K/mammalian target of rapamycin (mTOR pathway inhibitors in both preclinical and clinical settings. In light of the recent discovery of tumor-initiating cancer stem cells (CSCs in various tumor types, we developed an in vitro CSC model from xenograft tumors established in mice from a colorectal cancer patient tumor in which the CD133+/EpCAM+ population represented tumor-initiating cells. CD133+/EpCAM+ CSCs were enriched under stem cell culture conditions and formed 3-dimensional tumor spheroids. Tumor spheroid cells exhibited CSC properties, including the capability for differentiation and self-renewal, higher tumorigenic potential and chemo-resistance. Genetic analysis using an OncoCarta™ panel revealed a PIK3CA (H1047R mutation in these cells. Using a dual PI3K/mTOR inhibitor, PF-04691502, we then showed that blockage of the PI3K/mTOR pathway inhibited the in vitro proliferation of CSCs and in vivo xenograft tumor growth with manageable toxicity. Tumor growth inhibition in mice was accompanied by a significant reduction of phosphorylated Akt (pAKT (S473, a well-established surrogate biomarker of PI3K/mTOR signaling pathway inhibition. Collectively, our data suggest that PF-04691502 exhibits potent anticancer activity in colorectal cancer by targeting both PIK3CA (H1047R mutant CSCs and their derivatives. These results may assist in the clinical development of PF-04691502 for the treatment of a subpopulation of colorectal cancer patients with poor outcomes.

  11. Estudio de la frecuencia de hemoglobinopatías en las islas de San Andrés y Providencia, Colombia

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    María del Pilar Bernal

    1995-03-01

    Full Text Available Se realizó un estudio destinado a determinar la frecuencia de hemoglobinopatías en las islas caribeñas de San Andrés y Providencia, en 544 individos individuos: 443 de San Andrés y 101 de Providencia. La frecuencia en San Andrés fue del 12,8% y en Providencia 20,8%; las hemoglobinopatías más frecuentes fueron: el rasgo falciforme, la hemoglobina C y la beta-talasemia. Los datos indican, que las hemoglobinopatías en esta región del país como problema de salud pública, tienen importancia y nos dan información sobre el origen geográfico de la población.

  12. A Transnational World Fractured but Not Forgotten: British West Indian Migration to the Colombian Islands of San Andrés and Providence

    Directory of Open Access Journals (Sweden)

    Sharika Crawford

    2011-06-01

    Full Text Available This article examines British West Indian migration to the Colombian archipelago of San Andrés and Providence in the late nineteenth to early twentieth century. While the United Fruit plantations, Panama Canal, oil fields in Venezuela, and railroad projects in Central America generated a strong demand for a large West Indian workforce, no such development took place on San Andrés and Providence. As a result, the profile of West Indian migration looks different than to the Spanish-speaking circum-Caribbean, with more professionals and merchants and fewer unskilled laborers. In the absence of mass migration, there was less hostility toward West Indian newcomers to San Andrés and Providence islands.

  13. La literacidad en el área urbana del municipio de San Andrés de Tumaco

    OpenAIRE

    Zárate Pinto, Germán Camilo

    2014-01-01

    El propósito de la investigación es tener un acercamiento a la literacidad del municipio de San Andrés de Tumaco, en la que se identifiquen rasgos propios, usos y valoraciones de las prácticas y eventos letrados. Por el carácter cognitivo y cultural de la propuesta se utilizaron estrategias de recolección de información propias de la investigación cualitativa ajustadas a los Nuevos Estudios de la Literacidad. Los instrumentos utilizados fueron la observación y la entrevista semiestructurada q...

  14. Survey of benthic dinoflagellates associated to beds of Thalassia testudinumin San Andres Island, Seaflower biosphere reserve, Caribbean Colombia

    International Nuclear Information System (INIS)

    Rodriguez E, Angelica; Mancera Pineda, J Ernesto; Gavio, Brigitte

    2010-01-01

    In order to determine the occurrence of epiphytic toxic dinoflagellates in the coastal waters of San Andres Island, Caribbean Colombia, we analyzed the sea grass beds on the northern and eastern sides of the island. We found seven species of toxicogenic dinoflagellates, belonging to the genera Prorocentrum and Ostreopsis. The cell densities were generally low if compared with previous studies in other Caribbean sites, ranging from 0 to 836 cells/dry weights. The species encountered are known to produce toxins causing the diarrheic shellfish poisoning and ciguatera, poisonings which have been documented in the island.

  15. André Blumel, un itinéraire sioniste à la croisée des chemins

    OpenAIRE

    Lafon, François

    2009-01-01

    Cet article envisage à travers l’itinéraire sioniste d’André Blumel les relations entre la gauche française et l’État d’Israël. Proche de Léon Blum, dont il fut directeur de Cabinet durant le Front populaire, mais se rapprochant progressivement des communistes, Blumel demeura jusqu’en 1966 une figure clefs des milieux sionistes français. Conciliant divers engagements – pourtant apparemment contradictoires – son parcours permet de comprendre la complexité des liens et des conflits qui caractér...

  16. Die Kunst der Projektion. Romantik und Dekonstruktion in den Filmen André Téchinés

    OpenAIRE

    Merlin, Dieter

    2012-01-01

    Thema der vorliegenden Untersuchung sind die Dekonstruktionsmechanismen, mit deren Hilfe metaphysisch begründete Liebeskonzeptionen in den Filmen des französischen Post-Nouvelle-Vague-Regisseurs André Téchiné (geb. 1943) einer kinematographischen Kritik unterworfen werden. Diese Mechanismen werden anhand einer Auswahl von fünf Filmen – HÔTEL DES AMÉRIQUES (1981), LES ROSEAUX SAUVAGES (1994), LES VOLEURS (1996), LOIN (2001) und LES TEMPS QUI CHANGENT (2004) – sowohl unter ästhetisch-formalen a...

  17. Representar, practicar y repensar el Patrimonio Cultural: el caso de San Andrés Calpan, Puebla

    OpenAIRE

    Arellano Espinosa, Andrea

    2015-01-01

    El presente texto es el resultado de una investigación antropológica sobre las representaciones sociales y las prácticas socioculturales en torno a un sitio patrimonio cultural: el ex convento de San Andrés Calpan, Puebla, uno de los primeros monasterios franciscanos edificados en México. Desde 1994 forma parte de la designación Primeros monasterios del siglo XVI en las laderas del Popocatépetl de la lista del Patrimonio de la Humanidad de UNESCO. Cuatro capillas posas, las más importantes po...

  18. Aussteigen (getting out Impossible—Montage and Life Scenarios in Andres Veiel’s Film Black Box BRD

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    Anja Katharina Seiler

    2016-02-01

    Full Text Available Andres Veiel’s 2001 documentary film, Black Box BRD, links the biography of Alfred Herrhausen, RAF victim, with one of the 3rdgeneration RAF terrorists, Wolfgang Grams. In my paper, I trace how the film’s aesthetics introduce an image montage of two life scenarios by establishing both parallels and contrast, and therefore, following Susan Haywards definition “creates a third meaning” (112. I examine how the film establishes an aesthetic concept of Aussteigen (getting out—along of the alive, visible bodies—the contemporary interviewees, and dead, invisible bodies—of Herrhausen and Grams.

  19. The natural population of bees of the earth (Melipona beecheii) and their flora in the valley San Andrés

    OpenAIRE

    Katiuska Ravelo Pimentel; Fernando Ramón Hernández Martínez; Iván Paneque Torres; Luisa Elena Toledo Peña; Hilda Gutiérrez Hernández

    2014-01-01

    The relationship of the natural population of bees of the earth is evaluated (Melipona beecheii) and its flora in the valley San Andrés, to inclination observations and samplings carried out in the formations studied vegetable. The melliferous plants and their use like tree of the nest of Melipona beecheii were studied for each one of the vegetable formations of the valley San Andrés, the indexes of diversity and their relationship were also analyzed with the values of density of colonies. It...

  20. Indústria, ordenamento do território e transportes – a contribuição de André Fischer

    Directory of Open Access Journals (Sweden)

    Áurea Breitbach

    2009-03-01

    Full Text Available Indústria, ordenamento do território e transportes – a contribuição de André Fischer, Organização Olga Lúcia C. Firkowski e Eliseu S. Sposito, Editora Expressão Popular, 2008, 160 p.Este livro é uma iniciativa conjunta dos Programas de Pós-Graduação em Geografia da Universidade Federal do Paraná e da Universidade Estadual Paulista/Presidente Prudente. Conforme os organizadores, a intenção foi publicar um livro que homenageasse André Fischer e, para tanto, foram reunidos diversos textos escrit...

  1. Youth map of the city of Santo André, Southeastern Brazil: an instrument to read social inequalities.

    Science.gov (United States)

    Yonekura, Tatiana; Soares, Cássia Baldini; Minuci, Elaine Garcia; Campos, Célia Maria Sivalli; Trapé, Carla Andrea

    2010-02-01

    To analyze social inequalities in young adults living in an urban area by mapping sociodemographic and economic data. Using data from the 2000 Demographic Census, 57 sociodemographic and economic variables of young adults aged from 15 to 24 years, living in the city of Santo André, Southeastern Brazil, were distributed among 43 areas of statistical data, corresponding to a division of the region into smaller districts. Data from the year 2000 were collected from the Santo André City Hall Department of Socioeconomic Indicators. Using factorial analysis, 13 variables were grouped in two factors - working conditions and life conditions, which distinguished areas that were similar to one another statistically. Cluster analysis of areas was performed, resulting in four social groups. The area that concentrated young adults with higher access to wealth was classified as central and that including individuals with lower access to wealth was classified as peripheral. Two intermediate areas could be identified, one closer to the highest access to wealth ('almost central') and another close to the lowest access to wealth ('almost peripheral'). Discriminating variables were associated with work, migration, level of education, fertility, adolescent's position in the household, presence of spouse or partner, living conditions and assets owned. Differences among social groups revealed important inequalities among young adults who live, study and/or work in the city, which will contribute to the planning of public social policies aimed at these groups.

  2. Kjøring med mistanke om påvirkning av andre rusmidler enn alkohol

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    Asbjørg S. Christophersen

    2009-10-01

    Full Text Available  SAMMENDRAGStatens rettstoksikologiske institutt har i løpet av de siste år registrert en stor økning av prøver fra bilføreremistenkt for kjøring under påvirkning av andre rusmidler enn alkohol. Antall positive saker økte 42% fra1994 til 1995. De hyppigste påviste stoffer er tetrahydrocannabinol, amfetamin, benzodiazepiner og opiater(morfin/kodein. Bruk av tyngre narkotiske stoffer har blitt mer vanlig i trafikksammenheng og antall positivetilfeller har økt betydelig mer enn totalt antall saker. Fra 1994 til 1995 økte antall positive amfetaminprøvermed 75% (fra 533 til 937 og antall positive prøver som følge av heroininntak økte med 87% (fra 92 til 172.Bruk av flere stoffer samtidig er vanlig, over 60 % av sakene i 1995 var positive på mer enn ett stoff, alkoholikke medregnet. De fleste tilfeller var representert av menn i alderen 25-32 år (37%. Kvinner var representerti ca. 11% av sakene.Christophersen AS, Skurtveit S, Mørland J. Drivers suspected to drive under the influence of drugs otherthan alcohol. Nor J Epidemiol 1996; 6 (1: 45-48.ENGLISH SUMMARYThe National Institute of Forensic Toxicology has registered a large increase in the number of samples fromdrivers suspected to drive under influence of drugs other than alcohol. The number of drug positive casesincreased 42% from 1994 to 1995. The most frequent drugs detected are tetrahydrocannabinol, amphetamine,benzodiazepines and opiates (morphine/codeine. The frequency of hard narcotic drug use has increased morethan the total number of cases. From 1994 to 1995, the number of amphetamine positive samples increased75% (from 533 to 937 and the number of samples positive due to heroin use (detection of the metabolite 6-monoacetylmorphine in urine increased 87%. Multi-drug use is common and more than one drug wasdetected in more than 60% of the cases from 1995, alcohol not included. Most of the cases were representedby men 25-32 years old (37%. Women were represented in about

  3. Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis

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    Raquel López-Mejías

    2014-01-01

    Full Text Available Introduction. Rheumatoid arthritis (RA is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT and presence/absence of carotid plaques and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA.

  4. Effective lifetime measurements in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$, $B^{0} \\rightarrow K^{+}\\pi^{-}$ and $B_{s}^{0} \\rightarrow \\pi^{+}K^{-}$ decays

    CERN Document Server

    INSPIRE-00258707; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves Jr, A.A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J.E.; Appleby, R.B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J.J.; Badalov, A.; Balagura, V.; Baldini, W.; Barlow, R.J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Bauer, Th.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjornstad, P.M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Borsato, M.; Bowcock, T.J.V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N.H.; Brown, H.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Garcia, L.Castillo; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Cheung, S.F.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P.E.L.; Clemencic, M.; Cliff, H.V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G.A.; Craik, D.C.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P.N.Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; de Miranda, J.M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Deleage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suarez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Esen, S.; Evans, T.; Falabella, A.; Farber, C.; Farinelli, C.; Farley, N.; Farry, S.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gavardi, L.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani', S.; Gibson, V.; Giubega, L.; Gligorov, V.V.; Gobel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Gotti, C.; Grabalosa Gandara, M.; Graciani Diaz, R.; Granado Cardoso, L.A.; Grauges, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grunberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S.C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S.T.; Harrison, J.; Hartmann, T.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J.A.; van Herwijnen, E.; Hess, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hunt, P.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jaton, P.; Jawahery, A.; Jezabek, M.; Jing, F.; John, M.; Johnson, D.; Jones, C.R.; Joram, C.; Jost, B.; Jurik, N.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T.M.; Kelsey, M.; Kenyon, I.R.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R.F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V.N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R.W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.P.; Lefevre, R.; Leflat, A.; Lefrancois, J.; Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Liu, G.; Lohn, S.; Longstaff, I.; Lopes, J.H.; Lopez-March, N.; Lowdon, P.; Lu, H.; Lucchesi, D.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Machikhiliyan, I.V.; Maciuc, F.; Maev, O.; Malde, S.; Manca, G.; Mancinelli, G.; Manzali, M.; Maratas, J.; Marchand, J.F.; Marconi, U.; Benito, C.Marin; Marino, P.; Marki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martin Sanchez, A.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; McSkelly, B.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D.A.; Minard, M.N.; Moggi, N.; Molina Rodriguez, J.; Monteil, S.; Moran, D.; Morandin, M.; Morawski, P.; Morda, A.; Morello, M.J.; Moron, J.; Mountain, R.; Muheim, F.; Muller, K.; Muresan, R.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A.D.; Nguyen, T.D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, G.; Orlandea, M.; Otalora Goicochea, J.M.; Owen, P.; Oyanguren, A.; Pal, B.K.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C.J.; Passaleva, G.; Patel, G.D.; Patel, M.; Patrignani, C.; Pazos Alvarez, A.; Pearce, A.; Pellegrino, A.; Pepe Altarelli, M.; Perazzini, S.; Perez Trigo, E.; Perret, P.; Perrin-Terrin, M.; Pescatore, L.; Pesen, E.; Petridis, K.; Petrolini, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilar, T.; Pinci, D.; Pistone, A.; Playfer, S.; Plo Casasus, M.; Polci, F.; Poluektov, A.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Rachwal, B.; Rademacker, J.H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M.S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Reichert, S.; Reid, M.M.; dos Reis, A.C.; Ricciardi, S.; Richards, A.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Roa Romero, D.A.; Robbe, P.; Rodrigues, A.B.; Rodrigues, E.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Vidal, A.Romero; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruffini, F.; Ruiz, H.; Valls, P.Ruiz; Sabatino, G.; Saborido Silva, J.J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Coutinho, R.Silva; Simi, G.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, N.A.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M.D.; Soler, F.J.P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spinella, F.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Subbiah, V.K.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szilard, D.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M.T.; Tresch, M.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Garcia, M.Ubeda; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vazquez Sierra, C.; Vecchi, S.; Velthuis, J.J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voss, C.; Voss, H.; de Vries, J.A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D.R.; Watson, N.K.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiedner, D.; Wilkinson, G.; Williams, M.P.; Williams, M.; Wilson, F.F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S.A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Xu, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W.C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zvyagin, A.

    2014-01-01

    Measurements of the effective lifetimes in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$, $B^{0} \\rightarrow K^{+}\\pi^{-}$ and $B_{s}^{0} \\rightarrow \\pi^{+}K^{-}$ decays are presented using $1.0~\\mathrm{fb^{-1}}$ of $pp$ collision data collected at a centre-of-mass energy of 7 TeV by the LHCb experiment. The analysis uses a data-driven approach to correct for the decay time acceptance. The measured effective lifetimes are $\\tau_{B_{s}^{0} \\rightarrow K^{+}K^{-}}$ = $1.407~\\pm~0.016~\\pm~0.007~\\mathrm{ps}$, $\\tau_{B^{0} \\rightarrow K^{+}\\pi^{-}}$ = $1.524~\\pm~0.011~\\pm~0.004~\\mathrm{ps}$, $\\tau_{B_{s}^{0} \\rightarrow \\pi^{+}K^{-}}$ = $1.60~\\pm~0.06~\\pm~0.01~\\mathrm{ps}$. This is the most precise determination to date of the effective lifetime in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$ decay and provides constraints on contributions from physics beyond the Standard Model to the $B_{s}^{0}$ mixing phase and the width difference $\\Delta\\Gamma_{s}$.

  5. Evaluation of a Voluntary Tutoring Program in Chemistry, Physics and Mathematics for First-Year Undergraduates at Universidad Andres Bello, Chile

    Science.gov (United States)

    Jiménez, Verónica A.; Acuña, Fabiola C.; Quiero, Felipe J.; López, Margarita; Zahn, Carmen I.

    2015-01-01

    This work describes the preliminary results of a tutoring program that provides personalized academic assistance to first-year undergraduates enrolled in introductory chemistry, physics and mathematics courses at Universidad Andres Bello (UNAB), in Concepción, Chile. Intervened courses have historically large enrolments, diverse student population…

  6. Tracing the development of contemporary park-city relationships : Parc de La Villette and Parc André Citroën (paper + presentation)

    NARCIS (Netherlands)

    Van der Velde, J.R.T.

    2012-01-01

    Since the late post--?war period the relationship between park and city has significantly altered. Parks established between 1980 and 2000 in Paris --? in particular Parc de La Villette and Parc André Citroën – exemplify developments in park design and the park--?city relationship in this period and

  7. Estonian Golf Countri Club'i Jägala golfiklubi sisekujundus. Jõelähtme, Mannila küla / Juta Lember, Andres Siim, Tarmo Luisk...[jt.

    Index Scriptorium Estoniae

    2006-01-01

    3 korruste plaani, värv. välisvaade, 22 sisevaadet; fotod: Kalle Veesaar; Juta Lember projekteeris ka tammepuust mööbli; arhitekt Andres Siim; nõupidamisruumi toolide ja nagide autor: Toivo Raidmets; metallvalgustite autor: Tarmo Luisk

  8. XII Avatud Ühiskonna Foorumi arutlusring "Euroopa hiilgus ja viletsus - Euroopa Liit 50. Kuidas edasi?" / Toomas Hendrik Ilves, Mark Leonard, Ivan Krastev ; intervjueerinud Andres Kasekamp

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    Pärnus diskuteerisid 10. oktoobril 2007 Euroopa tuleviku teemadel president Toomas Hendrik Ilves, Euroopa Välissuhete Nõukogu tegevjuht Mark Leonard ja Sofias paikneva Liberaalstrateegiate Keskuse juht Ivan Krastev. Vestluse moderaator oli Eesti Välispoliitika Instituudi direktor, Avatud Eesti Fondi nõukogu esimees Andres Kasekamp

  9. Marine macroalgae in the agronomy and potential use of floating sargassum for manure production in the San Andres and Providencia Archipelago, Colombia

    International Nuclear Information System (INIS)

    Bula Meyer, German

    2004-01-01

    An account is made on the use of marine macroalgae in agronomy and the potential that floating Sargassum arriving to san Andres and Providencia has for this activity. This Sargassum, which has been a nuisance for the tourist economy of the islands, promises to be an excellent resource for manure production

  10. Stygofauna of the Canary Islands, 4. Liagoceradocus acutus Andres, 1978, a blind anchihaline amphipod from Lanzarote: redescription, taxonomic status and occurrence

    NARCIS (Netherlands)

    Rondé-Broekhuizen, Brigitte L.M.; Stock, Jan H.

    1987-01-01

    Liagoceradocus acutus Andres, 1978, has been found in different localities on Lanzarote, Canary Islands. A redescription is provided and the taxonomic status of the genus Liagoceradocus is discussed. The species shows sexual dimorphism mainly in the morphology of the propodus of gnathopods 1 and 2,

  11. Process optimisation of microwave-assisted extraction of peony ( Paeonia suffruticosa Andr .) seed oil using hexane-ethanol mixture and its characterisation

    Science.gov (United States)

    Xiaoli Sun; Wengang Li; Jian Li; Yuangang Zu; Chung-Yun Hse; Jiulong Xie; Xiuhua Zhao

    2016-01-01

    Ethanol and hexane mixture agent microwave-assisted extraction (MAE) method was conducted to extract peony (Paeonia suffruticosa Andr.) seed oil (PSO). The aim of the study was to optimise the extraction for both yield and energy consumption in mixture agent MAE. The highest oil yield (34.49%) and lowest unit energy consumption (14 125.4 J g -1)...

  12. André Gide en Égypte : l’inachèvement et la créativité

    Directory of Open Access Journals (Sweden)

    Elizabeth Geary Keohane

    2014-12-01

    Full Text Available Cet article analyse un ouvrage d’André Gide, Carnets d’Égypte, dans le contexte de ‘late style’, un concept adornien développé par Edward Said. Bien que Carnets d’Égypte représente un des derniers ouvrages de Gide, il ne s’agit pas d’une tentative de créer une impression de complétude ni de couronner une œuvre variée. C’est plutôt un espace créatif où il peut se permettre de se concentrer sur l’inachèvement. Nous examinons donc ce que Gide a choisi de ne pas ‘terminer’ ou même de ne pas ‘finaliser’ – le voyage lui-même et surtout le processus d'écriture qui s'ensuit. Pour Said, ‘late style’ est une attitude que nous pouvons déceler chez certains auteurs qui se trouvent devant la mort. Se concentrer sur l’inachèvement et non sur la complétude dans un tel cas révèle une certaine résistance chez Gide qui est tout de même productive, car elle arrive à faire avancer le processus d’écriture. André Gide in Egypt: the Unfinished and the Creative Process This article analyses a work by André Gide, Carnets d’Égypte, in the context of 'late style', an Adornian concept developed by Edward Said. Although Carnets d’Égypte is one of Gide’s final works, it does not attempt to create a sense of completeness nor does it attempt to crown a varied body of work. It is instead a creative space where he can allow himself to concentrate on the incomplete or the unfinished. I therefore examine what Gide has chosen not to ‘finish’ or even not to ‘finalise’ – that is, the journey itself and more particularly, the related writing process. For Said, ‘late style’ is an attitude that can be detected in certain authors facing death. Concentrating in such a case on what remains unfinished, instead of on completeness, reveals a certain resistance on Gide’s part which is nonetheless productive, since it manages to advance the writing process.

  13. Estimate the potential production of electricity: a case study of the sanitary landfill of Santo Andre, Sao Paulo, Brazil; Estimativa do potencial de producao de eletricidade: estudo de caso do aterro sanitario de Santo Andre, Sao Paulo, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Elissando Rocha da; Moreira, Joao M. L.; Candiani, Giovano [Instituto Federal de Educacao, Ciencia e Tecnologia de Sao Paulo (IFSP), SP (Brazil)

    2010-07-01

    The recovery of the biogas generated from sanitary landfills, associated to its energetic use has been widely discussed. Thus, this paper aims to estimate the potential production of electric energy from sanitary landfill Santo Andre-SP. The biogas production was estimated using the rate of deposition of solid wastes in the landfill, using some mathematical models with parameters suggested by two models: LanGEM-USEPA (conventional landfill) and Word Bank. These results indicate that the potential of biogas production will be approximately 11 x 10{sup 6} Kg of methane/year in 2017 and production of electric energy in that year will be approximately 32,000 MWh, considering an of 75% over collection of biogas. (author)

  14. André Pichot, Aux origines des théories raciales. De la Bible à Darwin

    Directory of Open Access Journals (Sweden)

    Anthony Feneuil

    2010-07-01

    Full Text Available « Le darwinisme n’est pas une théorie scientifique qui a connu maintes dérives idéologiques, c’est une idéologie à qui la génétique a fini par donner un aspect à peu près scientifique » (p. 299. Telle est la thèse qui conduit André Pichot, dans son dernier livre, à opérer un bouleversement des catégories habituelles de pensée : Darwin n’est plus le champion de la vision scientifique du monde en lutte contre la conception obscurantiste du créationnisme et du finalisme religieux, mais l’une de...

  15. Estudios sobre los uredinales del archipiélago de San Andrés y providencia, Colombia.

    Directory of Open Access Journals (Sweden)

    Pardo Cardona Víctor Manuel

    2003-12-01

    Full Text Available Doce especies de Uredinales fueron colectados en las islas de San Andrés y Providencia durante una visita de colección efectuada en el mes de Octubre de 2002. Los hospederos fueron determinados y herborizados y a partir de ellos se elaboraron micropreparados que contenían los soros con las esporas de los hongos, los cuales fueron observados y estudiados al microscopio. Puccinia cyperi-tagetiformis Kem es nuevo registro para Colombia; se registró a Brachiaria distachya (L Stapf como nuevo hospedante de Uromyces clignyi Patouillard & Hariot y a Cyperus rotundus L como nuevo hospedante para P. cyperi-tagetiformis. Las demos especies colectados han sido registradas en el neotrópico sobre hospedantes previamente conocidos.

  16. How Two Sides of the Atlantic Contributed to Understanding of the Global Oceans: Charles Yentsch and Andre Morel

    Science.gov (United States)

    Acker, James G.

    2013-01-01

    In a few short days in September of this year, the ocean color/ocean optics community lost two of the founding members of its Hall of FameCharles Yentsch and Andre Morel. Yentsch passed away at the age of 85 on September 19, and Morel passed away on September 23 at the age of 79. It might sound clich to say that someone was instrumental to the advance of science in a particular field, but in the case of Yentsch and Morel and ocean color instrumentation, such an assessment would likely be accurate. Each mans career complimented that of the other Yentsch was one of the first to make measurements of the light field of the ocean from altitude and to advocate an instrument in space that could observe the spectrum of ocean radiance Morels theoretical underpinnings established a firm foundation for the measurements such an instrument could make, allowing their successful interpretation.

  17. Thermal comfort in twentieth-century architectural heritage: Two houses of Le Corbusier and André Wogenscky

    Directory of Open Access Journals (Sweden)

    Ignacio Requena-Ruiz

    2016-06-01

    This article aims to develop a balanced understanding of the approach of Modernist architecture to climate, indoor atmospheres and inhabitants׳ thermal comfort. To do so, we complement the quantitative approach of environmental assessment methods with the qualitative angle of the history of sensory and architecture. The goal is to understand the environmental performance of architecture for dealing nowadays with thermal comfort issues while respecting its cultural and historical values. Two modernist houses have been selected as case studies: the Villa Curutchet of the master Le Corbusier and the Villa Chupin of his disciple André Wogenscky. As a result, the article reveals potentialities and constraints in terms of thermal comfort when working with Modern Architecture.

  18. ANGIOSPERM FLAG SPECIES FOR MANGROVE CONSERVATION IN San AndrÉs Island (colombia ARE HIGHLY VULNERABLE AND locally rare

    Directory of Open Access Journals (Sweden)

    Gloria Andrea Murcia

    2016-01-01

    Full Text Available El concepto de especies bandera ha sido empleado en proyectos de conservación por 50 años. Se proponen aquí cinco especies nativas de la Isla de San Andrés como especies bandera para la conservación de los pocos remanentes de manglar en esta Isla: Bontia daphnoides (Myoporaceae, Canella winterana (Canellaceae, Eustoma exaltatum (Gentianaceae, Rhabdadenia biflora (Apocynaceae y Selenicereus grandiflorus (Cactaceae. Cuatro de estas especies son documentadas aquí por primera vez para el Archipiélago, y tres representan los primeros reportes para la Flora de Colombia, dos de ellos (Canellaceae y Myoporaceae a nivel de familia.

  19. Review: André du Pisani, Reinhart Kössler, and William A. Lindeke (eds., The Long Aftermath of War: Reconciliation and Transition in Namibia (2010 Buchbesprechung: André du Pisani, Reinhart Kössler und William A. Lindeke (Hrsg., The Long Aftermath of War: Reconciliation and Transition in Namibia (2010

    Directory of Open Access Journals (Sweden)

    Dag Henrichsen

    2011-01-01

    Full Text Available Review of the edited volume: André du Pisani, Reinhart Kössler, and William A. Lindeke (eds., The Long Aftermath of War: Reconciliation and Transition in Namibia (Freiburger Beiträge zu Entwicklung und Politik, 37, Freiburg: Arnold-Bergstraesser-Institut, 2010, ISBN 978-3-928597-55-5, 437 pp.Besprechung des Sammelbandes: André du Pisani, Reinhart Kössler und William A. Lindeke (Hrsg., The Long Aftermath of War: Reconciliation and Transition in Namibia (Freiburger Beiträge zu Entwicklung und Politik, 37, Freiburg: Arnold-Bergstraesser-Institut, 2010, ISBN 978-3-928597-55-5, 437 Seiten

  20. PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab

    DEFF Research Database (Denmark)

    Jensen, J D; Knoop, Ann; Laenkholm, A V

    2012-01-01

    -stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab. PATIENTS AND METHODS: Two hundred and forty HER2-positive early-stage breast cancer patients receiving adjuvant treatment (cyclophosphamide 600 mg/m(2), epirubicin 60 mg/m(2), and fluorouracil 600 mg/m(2)) before administration...... of 1 year trastuzumab were assessable. PTEN and pHER2 expression were assessed by immunohistochemistry. PIK3CA mutations (exons 9 and 20) were determined by pyrosequencing. RESULTS: Five-year overall survival (OS) and invasive disease-free survival were 87.8% and 81.0%, respectively. Twenty-six percent...... activity had a significantly poorer survival despite adequate treatment with adjuvant chemotherapy and trastuzumab....

  1. Mapa das juventudes de Santo André, SP: instrumento de leitura das desigualdades sociais Mapa de las juventudes de Santo André, Sureste de Brasil: instrumento de lectura de las desigualdades sociales Youth map of the city of Santo André, Southeastern Brazil: an instrument to read social inequalities

    Directory of Open Access Journals (Sweden)

    Tatiana Yonekura

    2010-02-01

    Full Text Available OBJETIVO: Analisar as desigualdades sociais de jovens moradores em área urbana pelo mapeamento de dados sociodemográficos e econômicos. MÉTODOS: Utilizando-se dados do Censo Demográfico 2000, 57 variáveis sociodemográficas e econômicas de jovens de 15 a 24 anos do município de Santo André, SP, foram distribuídas por 43 regiões de dados estatísticos que correspondem a um recorte do território em distritos menores. Os dados foram coletados no Departamento de Indicadores Sociais e Econômicos da Prefeitura Municipal de Santo André, referentes ao ano 2000. Por meio de análise fatorial, 13 variáveis foram agrupadas em dois fatores - condições de trabalho e condições de vida, que discriminaram estatisticamente regiões semelhantes entre si. Foi realizada análise por agrupamento das regiões, resultando em quatro grupos sociais. RESULTADOS: O espaço que concentrava os jovens com mais acesso à riqueza foi classificado como central e aqueles com menos acesso, como periférico. Duas gradações intermediárias puderam ser identificadas, uma mais próxima ao extremo do acesso ("quase central" e outra mais próxima à privação ("quase periférica". As variáveis discriminantes estavam relacionadas ao trabalho, à migração, escolaridade, fecundidade, posição do jovem no domicílio, presença de cônjuge ou companheiro, condição de moradia e posse de bens. CONCLUSÕES: As diferenças entre os grupos sociais expressaram desigualdades importantes entre os jovens que vivem, estudam e/ou trabalham na cidade, o que contribuirá para o planejamento de políticas sociais públicas dirigidas a esses grupos.OBJETIVO: Analizar las desigualdades sociales de jóvenes moradores en área urbana por el mapeo de datos sociodemográficos y económicos. MÉTODOS: Utilizándose datos del Censo Demográfico 2000, 57 variables sociodemográficas y económicas de jóvenes de 15 a 24 años del municipio de Santo André, Sureste de Brasil, fueron

  2. The natural population of bees of the earth (Melipona beecheii and their flora in the valley San Andrés

    Directory of Open Access Journals (Sweden)

    Katiuska Ravelo Pimentel

    2014-06-01

    Full Text Available The relationship of the natural population of bees of the earth is evaluated (Melipona beecheii and its flora in the valley San Andrés, to inclination observations and samplings carried out in the formations studied vegetable. The melliferous plants and their use like tree of the nest of Melipona beecheii were studied for each one of the vegetable formations of the valley San Andrés, the indexes of diversity and their relationship were also analyzed with the values of density of colonies. It was determined that the density of colonies of bees of the earth is directly related with the wealth and diversity of species of melliferous plants found in the study area. He was also proven that the arboreal species more used as tree of the nest they are: Bursera simaruba, Guazuma ulmifolia, Psidium guajava, Mangifera indica and Roystonea regia.

  3. Mida teed siis, kui töötaja on avaldanud soovi firmast lahkuda? / Inge Rumessen, Andres Hall, Mariliin Saar ... [jt.

    Index Scriptorium Estoniae

    2016-01-01

    Küsimusele vastavad PR Strategies partner ja strateegiline konsultant Inge Rumessen, auto24ring juhataja Andrs Hall, vabakutseline loovjuht ja produtsent Mariliin Saar, advokaadibüroo Tark partner Hannes Küün, ettevõtte Ööloom ja Frank kaasasutaja Jan Plaan, haridus- ja teadusministeeriumi personaliosakonna juhataja Margot Saluse, Sorry as Service müügijuht ja asutaja Indrek Põldvee ja EBS-i rahvusvahelise koostöö prorektor Toomas Danneberg

  4. André Freire, Esquerda e Direita na Política Europeia : Portugal, Espanha, e Grécia em Perspectiva Comparada

    OpenAIRE

    Pitcher, Anne

    2016-01-01

    Andre Freire has produced an exhaustive study of ideological orientations in the relatively new democracies of southern Europe – Portugal, Spain and Greece. The primary objective of the book is to ascertain how ideological and party identities in these new democracies compare with those in the old democracies of Western Europe such as Belgium, France, Great Britain, Germany, and Italy and the degree to which divisions along a left-right dimension continue to define political values across Eur...

  5. Arhitektuuri sihtkapitali tegevuspreemia 2014 = The Endowment for architecture's prize for activity in the field of architecture 2014 / Epp Lankots, Andres Kurg ; kommenteerinud Ignar Fjuk

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2015-01-01

    Eesti Kultuurkapitali Arhitektuuri sihtkapitali tegevuspreemia 2014: Epp Lankotsa doktoriväitekiri "Moodsa arhitektuuri kriitiline historiograafia. Modernsuse käsitlused Leo Gensi ja Leonhard Lapini arhitektuuriajaloolistes tekstides 1960.-1980. aastail"; Andres Kure doktoriväitekiri ""Boundary disruptions: late-soviet transformations in art, space and subjectivity in Tallinn 1968-1979" ("Segilöödud piirid, hilisnõukogude muutused kunstis, ruumis ja subjektsuses Tallinnas aastatel 1968-1979")

  6. Teresa Andrés Zamora (1907-1946: el compromiso social y político como arma de cultura

    Directory of Open Access Journals (Sweden)

    Seguí i Francés, Romà

    2010-12-01

    Full Text Available La biografía de Teresa Andrés Zamora (Villalba de los Alcores, 1907- París, 1946 es un claro ejemplo de cómo el compromiso de una mujer republicana a través de la cultura se transformó en beligerancia política. Este artículo quiere mostrar una imagen de Teresa Andrés más profunda que la de una bibliotecaria que militó en el PCE, pretendiendo reconstruir su recorrido vital tanto en la faceta académica como profesional y política, con el objetivo de presentar una evolución que va desde su paso por la Residencia de Señoritas hasta su prematura muerte en París. Teresa Andrés Zamora representa una generación de mujeres republicanas que fue leal a la II República, trabajando incansablemente durante la Guerra Civil, y que padeció el exilio en una Francia ocupada.

  7. Qualidade pós-colheita de frutos de tomate cv. Andréa tratados com etileno Postharvest quality of tomato fruits cv. Andréa treated with ethylene

    Directory of Open Access Journals (Sweden)

    Caroline Andreuccetti

    2007-03-01

    Full Text Available O tomate é uma das principais hortaliças cultivadas no Brasil e tratamentos que propiciem o controle do amadurecimento são extremamente desejáveis. Avaliou-se a qualidade pós-colheita de tomates tipo italiano tratados com etileno. Tomates 'Andréa' foram colhidos em campos de produção comercial no estádio verde-maduro, selecionados para presença de danos externos e classificados quanto ao tamanho e cor e posteriormente foram tratados com 100 µL L-1 de etileno. Os ensaios foram planejados com delineamento inteiramente casualizado em esquema fatorial com quatro tratamentos e quinze repetições (n=10. Após a aplicação, os frutos foram divididos em dois lotes. Um lote permaneceu a 20º±1ºC e outro foi mantido a 12,5º±1ºC, ambos sob umidade relativa 90±5%. Tomates do tratamento controle foram mantidos nas mesmas condições de temperatura e umidade relativa. Os frutos foram avaliados após cada mudança de estádio de amadurecimento para as seguintes variáveis: coloração externa (L*a*b*, perda de massa, sólidos solúveis totais, acidez titulável e teor de ácido ascórbico. A aplicação de etileno não influenciou de maneira significativa as variáveis químicas e físicas estudadas. Frutos armazenados à temperatura de 20ºC demonstraram maior porcentagem de perda de massa ao longo do amadurecimento, com média de 2,60%. A relação brix/acidez apresentou pouca variação entre os tratamentos avaliados. Frutos do tratamento controle e mantidos à temperatura de 20ºC apresentaram mudança de coloração mais rápida no início dos experimentos, não sendo observada posteriormente diferença significativa no desenvolvimento da cor dos tratamentos avaliados. O tratamento com etileno não acelerou de forma significativa o amadurecimento de tomates 'Andréa' armazenado sob as duas temperaturas estudadas.Tomatoes are one of the most important vegetable crops grown in Brazil and treatments that facilitate ripening control are

  8. Uso y actitudes relacionados a las drogas en las estudiantes de enfermería de la Universidad Mayor de San Andrés Uso e atitudes relacionados às drogas em estudantes de enfermagem da Universidade Maior de San Andres Use and attitudes about drugs among nursing students at the Universidad Mayor de San Andres

    Directory of Open Access Journals (Sweden)

    Iblin Elizabeth Enriquez Flores

    2004-04-01

    Full Text Available Este trabajo representa los resultados del Uso y Actitudes relacionando el alcohol, tabaco, Hojas de coca, tranquilizantes y anfetaminas en Estudiantes de Enfermería de la Universidad Mayor de San Andrés. El objetivo es analizar las actitudes mediante el uso de diferentes substancias con aquellos que no usan en los últimos 12 meses. Los datos fueron recolectados en Agosto del 2002, utilizando un cuestionario auto administrado y distribuido, garantizando el anonimato. Se obtuvieron estos resultados: Las actitudes relacionadas a las drogas aprueban el uso de hojas de coca, uso de alcohol, uso de tranquilizantes y desaprueban el uso de cocaína. El uso personal de drogas en los últimos 12 meses corresponde a: hojas de coca diariamente, alcohol menos que una vez por semana y tabaco diariamente. El principal motivo de uso de estas drogas vinculase a la práctica religiosa; los estudiantes son introducidos por primera vez por familiares y por amigos/enamorados.Este trabalho representa os resultados do Uso e Atitudes relacionados ao álcool, tabaco, folhas de coca, tranqüilizantes e anfetaminas em estudantes de enfermagem da Universidade Mayor de San Andrés. O objetivo é analisar as atitudes mediante o uso das diferentes substâncias com aqueles que usaram ou não drogas nos últimos 12 meses. Os dados da amostra estratificada e intencional foram coletados em agosto de 2002, utilizando um questionário auto administrado distribuído para preservar o anonimato. Obtiveram-se estes resultados: as atitudes relacionadas às drogas demonstram a aprovação do uso das folhas de coca, álcool, tranqüilizantes e desaprovam o uso da cocaína. O uso pessoal de drogas nos últimos 12 meses corresponde a: às folhas de coca diariamente, ao álcool menos que uma vez por semana, e tabaco diariamente. O principal motivo do uso destas drogas vincula-se a prática religiosa; os estudantes são introduzidos pela primeira vez pelos familiares, pelos amigos

  9. Microbial Inoculantes Effects on Growth Promotion of Mangrove and Citrullus vulgaris San Andrés Isla, Colombia

    Directory of Open Access Journals (Sweden)

    Tania Galindo

    2006-01-01

    Full Text Available In order to test the effect of two microbial inoculants (obtained from red and black mangrove roots on the growth and stability of mangrove and watermelon plants, four treatments were carried out in San Andres Island, Colombia. The treatments consisted in the application of the inoculants in: A. germinans propagules collected in a mangrove area, and then individually planted in gavels with sun-pasteurized soil (in order to decrease the microbial load, A. germinans and R. mangle plants collected in the proximity of nursery trees, A. germinans and R. mangle planted and maintained in nursery, and in Citrullus vulgaris seeds planted in a traditional cultivar without chemical fertilizers. The growth and vegetative development variables were: number of nodes, number of leaves and steam length. The inoculants (phosphate solubilizing microorganisms -PSM- and nitrogen fixing bacteria -NFB- were applied in the mentioned vegetable material, doing measures during three months. The results show a positive effect on growth measured by steam length in plants treated specifically with the inoculants in C. vulgaris and A. germinans seedlings maintained in nursery.

  10. El arte de la conversión: modelos educativos del Colegio de San Andrés de Quito

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    Andrea Lepage

    2007-06-01

    Full Text Available El ensayo analiza el papel que desempeñó el Colegio de San Andrés de Quito en la conversión de los indígenas durante el siglo XVI y el florecimiento de un centro importante de producción artística. El artículo propone que la designación actual del colegio, como una escuela de arte, puede ser una consecuencia tardía de la inestable relación entre arte y religión, tal como fue cultivada dentro de la institución franciscana. Se trató, por lo tanto, de una superposición del valor religioso sobre el artístico, mediante el cual se adoctrinaba a los estudiantes. El artículo enfatiza en la apropiación de destrezas artísticas por parte de los indígenas, quienes adquirieron dominio sobre estas artes, las mercadearon y provocaron una inesperada tensión en las concepciones franciscanas acerca de la religión y el uso del arte.

  11. A "coca-cola" shape: cultural change, body image, and eating disorders in San Andrés, Belize.

    Science.gov (United States)

    Anderson-Fye, Eileen P

    2004-12-01

    Eating disorders have been associated with developing nations undergoing rapid social transition, including participation in a global market economy and heavy media exposure. San Andrés, Belize, a community with many risk factors associated with the cross-cultural development of eating disorders, has shown remarkable resistance to previously documented patterns, despite a local focus on female beauty. Drawing on longitudinal person-centered ethnography with adolescent girls, this article examines why this community appears exceptional in light of the literature. First, community beauty and body image ideals and practices are explicated. Then, a protective ethnopsychology is proposed as a key mediating factor of the rapid socio-cultural change among young women. Finally, possible nascent cases of eating disordered behavior are discussed in light of their unique phenomenology: that is, having to do more with economic opportunity in the tourism industry and less with personal distress or desire for thinness. Close, meaning-centered examination of eating and body image practices may aid understanding and prevention of eating disorders among adolescents undergoing rapid social change in situations of globalization and immigration.

  12. Experiência e Utopia em Theodor W. Adorno, André Gorz e François Dubet

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    Sílvio César Camargo

    2007-01-01

    sociedade contemporânea. Conceito bastante complexo quanto a sua possibilidade de apreensão pela sociologia, experiência se refere tanto a problemas relativos ao conhecimento e suas possibilidades, mas também para as possibilidades de transformação da sociedade. Entende-se que há três teóricos da sociedade contemporânea, que partindo de bases epistemológicas diferentes, problematizam a emancipação humana a partir de uma singular atenção ao conceito de experiência. Theodor W. Adorno, André Gorz e François Dubet representam três formas de pensamento sobre a sociedade bastante diferentes, mas que possuem em comum o interesse normativo, e seu confronto nos mostra a importância do conceito de experiência para a compreensão da sociedade contemporânea e para pensar-se a utopia.

  13. As marcas de (intersubjetividade nas tiras de André Dahmer: uma análise enunciativa

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    Lucy Peres Farias

    2017-07-01

    Full Text Available Dos estudos postulados por Benveniste (1956 compreendemos que desde que nos declaramos locutores, nos apropriando da língua para enunciar, automaticamente implantamos o outro diante de nós, em maior ou menor grau de presença. Este artigo objetiva analisar tirinhas do autor André Dahmer na perspectiva do sujeito e intersubjetividade estudada por Benveniste (1956, explicando de que maneira se dá essa intersubjetividade, explicando os efeitos de sentido que são construídos a partir de marcas de sujeito encontradas. Para tanto, as categorias utilizadas serão, principalmente, as noções de pessoa e não pessoa, de Benveniste (1956, operações de localização, de Culioli (1982, apud CAMPOS, 1994, 1997 e modalidades, segundo Neves (2012. Os resultados obtidos a partir da análise mostraram a ocorrência de algumas marcas mais frequentes que outras, e pudemos perceber que a construção de sentidos de humor e crítica está imbricada às escolhas dessas categorias e marcas nos enunciados, marcas essas importantes para a relação de (intersubjetividade na perspectiva Culioliana.

  14. War songs and songs of war: the poetry in B minor by Fabrizio De André

    Directory of Open Access Journals (Sweden)

    Gleiton Lentz

    2010-11-01

    Full Text Available The 2nd half of last century, the Italian composer Fabrizio De André (1940-1999 occupied a prominent place in the history of Italian song and even the modern Italian poetry. His fans admire the moral courage and artistic coherence with which he, in the post-war Italian society, through his libertarian and pacifist songs, portrayed the world of the marginalized, the rebels and the prostitutes, and other characters on the margins of society, among those, the war combatant, hero of lost victories on the battlefield. Three of his songs are emblematic: La Ballata dell'eroe, La Guerra di Piero and Girotondo. Three poems that talk about war, death, and the figure of the combatant as an outcast of society, that kills him and then relegates him to oblivion, on behalf of the Fatherland. Exposing his provocative vision of post-war society by showing two videos of the composer is the purpose of this presentation.

  15. New urban and regional management instruments: Santo André and the Tamanduateí axis project case

    Directory of Open Access Journals (Sweden)

    Margarida Nobue Sakata

    2009-06-01

    Full Text Available From the end of twenty century, the crisis that came with to the end of the intensive capitalism system have been motivated much political and economical transformation at global scale. The post war breakdown reconstruction, oil crisis, the advances in informatics and telecommunication caused changes in the regional structure of many countries in the world. The movement of manufacturing activities of the old industrial metropolis occasioned the decadence and ascension of different urban regions. As an answer to these transformations, the paradigm of urban politics of many cities has been changed with the dismantling of the traditional planning system and accepting new management and urban intervention forms, as strategic planning, big urban projects, urban legislation flexibility, city marketing, etc. Recently many authors have done a critical review of this new urban management. This present work analyses the transformations suffered by Santo André, municipality of São Paulo metropolitan region and the implementation of Tamanduateí Axis Project, analyzing them in this context and these new urban management forms, evaluating its impacts and results.

  16. Il limite e l’altrove: il mito di Jean-Paul Belmondo nella Siberia di Andreï Makine The Bound and the Elsewhere: the Myth of Jean-Paul Belmondo in Andreï Makine’s Siberia

    Directory of Open Access Journals (Sweden)

    Elisabetta Abignente

    2011-04-01

    Full Text Available The narrative work of Andreï Makine (1957, a French writer of Siberian origin, is situated on the border between two geographical and cultural spaces: on the one hand the wide, wild and snowy Siberia of his childhood; on the other hand France, a mythic place which the main characters, often teenagers, of his novels look at as a model. The contrast between these two worlds is described in a particularly forceful way in one of his early novels, Au temps du fleuve Amour (1994, in which the author tells the overwhelming effect of the screening of a popular French comedy with Jean-Paul Belmondo (Le Magnifique, 1973 in a small Siberian village. Looking closely at the entire sequence which is devoted to the film in the novel, the paper aims to reconstruct the process of mythicizing the Belmondo character by the three young protagonists and to investigate the functions that the episode covers in the novel. Focusing on the different narrative levels that characterize the film plot, we show how the “phenomenon Belmondo” embodies in the novel the idea of a triple border: a geographic one (Europe/Asia, an expressive one (writing/imagine and, above all, an imaginary one (reality/fiction. We also show how this phenomenon refers, in the novel, to one of the central themes of Makine’s work: literary vocation.The narrative work of Andreï Makine (1957, a French writer of Siberian origin, is situated on the border between two geographical and cultural spaces: on the one hand the wide, wild and snowy Siberia of his childhood; on the other hand France, a mythic place which the main characters, often teenagers, of his novels look at as a model. The contrast between these two worlds is described in a particularly forceful way in one of his early novels, Au temps du fleuve Amour (1994, in which the author tells the overwhelming effect of the screening of a popular French comedy with Jean-Paul Belmondo (Le Magnifique, 1973 in a small Siberian village. Looking

  17. La lunga ombra dell’anarchico. Aspetti della narrativa di Andrés Carranque de Ríos

    Directory of Open Access Journals (Sweden)

    Barbara Minesso

    2012-01-01

    Full Text Available Dopo anni di oblio, Andrés Carranque de Ríos (1902-1936 sta ritrovando il suo giusto spazio nella critica e presso i lettori. Il proposito del presente lavoro è delineare la figura dello scrittore, praticamente sconosciuto in Italia, e analizzare alcuni aspetti della sua prosa giornalistica e narrativa. Si studierà l’importante e controverso legame con il cinema che conosceva la sua timida alba in Spagna, si analizzeranno i racconti pubblicati sulla rivista illustrata «Estampa» e si metteranno in luce alcuni aspetti dei suoi tre romanzi: «Uno» (1934, «La vida difícil» (1935, «Cinematógrafo» (1936. Carranque appartiene a quella generazione di scrittori della Repubblica che fanno della letteratura uno strumento di denuncia sociale, convergendo sulla necessità di superare l’elitismo borghese dell’avanguardia per rivolgersi alle masse, raccontando le dure condizioni di vita della classe operaia. La letteratura di Carranque non è però propagandistica: rifiuta l’addottrinamento di partito per denunciare le ferite aperte del corpus sociale in una prospettiva neorealista. Tutto ciò viene dalla sua esperienza diretta: una vita di ristrettezze economiche che lo obbligano a dedicarsi fin da giovanissimo ai lavori più svariati, in Spagna e in Europa. Il suo anarchismo lo porta due volte in carcere e il tempo della reclusione è dedicato alla lettura disordinata a vorace. Nonostante una vita al margine nel 1935 viene scelto, insieme ad alcuni grandi della letteratura, come delegato spagnolo nel Primo Congresso Internazionale di scrittori in difesa della Cultura realizzato a Parigi. After years of being ignored as a writer by critics and readers, Andrés Carranque de Ríos (1902-1936 is finding his deserved place. The aim of this work is to outline the figure of this writer, almost unknown in Italy, and analyze some aspects of his narrative and journalistic prose. We will study as well the important and controversial relation

  18. Inductores de lágrimas: andrógenos y gammaglobulinas humanas Tears inducers: androgens and human gammaglobulinas

    Directory of Open Access Journals (Sweden)

    María Nila Santos Lagresa

    2000-06-01

    Full Text Available Se comparan las respuestas terapéuticas en pacientes con diagnóstico de Síndrome de Sjögren que padecen de queratoconjuntivitis seca resistentes a los tratamientos tradicionales de lágrimas artificiales, lentes y otros, en dos grupos de pacientes de 18 y 32 casos con tratamientos de gammaglobulina humana: intacglobín (100 mg por kilo de peso cada 15 días por vía subcutánea interescapular por 3 meses y andrógenos de depósito (100 mg cada 15 días por vía im durante 3 meses. Se evaluaron los niveles de inmunoglobulinas IgG, IgA, IgM e IgE, recuento de células sanguíneas factor reumatoideo, proteína C reactiva y estudio microbiológico. Ambas terapéuticas muestran una mejoría estadísticamente significativa p Therapeutical responses are compared in patients diagnosed of Sjögren syndrome, presenting with keratoconjunctivitis sicca resistant to traditional treatments of artificial tears, lenses and others in two groups of patients (18 and 32 cases treated with human gammaglobulin: intacglobin (100 mg/body weight every 15 days in a intercapsular subcutaneos way for 3 months, and depot androgens (100 mg every 15 days in an intramuscular way for three months. Level of IgG, IgA, IgM, and IgE immunoglobulins, count of blood cells-rheumatoid factor, C-reactive protein, and microbiological study. Both treatments show an significant statistically improve p < 0,001 in results obtained in Shirmer I test, and in negative corneal injuries, assessed using slit lamp after fluorescein staining. We propose advantageous use of gammaglobulins because of contraindications on utilization of androgens.

  19. Apartheid Spies: The Character, the Reader, and the Censor in André Brink’s A Dry White Season

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    Giuliana Iannaccaro

    2014-05-01

    Full Text Available André Brink’s novel A Dry White Season (1979 is strictly connected with the time and place in which it was written. Its dialogue with the real Johannesburg of the late Seventies is manifest: characters and plot are grafted on real events, like the youth riots in Soweto (1976 and the death of Steve Biko in the hands of the Security Police (1977. Brink’s early novels have been commended for their political commitment, but also criticized for being ‘easily’ documentary. Yet, A Dry White Season’s structure is rather complex, and its fabricated nature is shown to the reader through the device of the double internal narrator and the considerable number of ‘documents’ discovered and employed – each telling its own truth. The metaphor of the ‘spying gaze’ proposed here is useful in order to point out the interconnections between story and history, as it shows the way in which a complex and multi-layered narrative structure succeeds in both reflecting and exposing the intricate apartheid system devised to control and ‘discipline’ its own citizens. In the novel, most of the characters intrude into the life of the others and are intruded upon, included peaceful citizens who are obliged to defend themselves from an oppressive and violent police State. At the same time, also the reader is drawn into the dangerous spying game, above all when he/she is introduced into that notorious site of interrogation, torture and detention which was the Johannesburg Police Station in John Vorster Square. The last part of the essay takes into consideration the South African censorship system in force at the time, to show that the activity of surveillance is both intrinsic to the narration and external, related to the conditions of the novel’s composition and appearance on the literary market.

  20. Sugerencias para la ejecución interpretativa de la obra “Movimiento” para Chelo y Piano del compositor Andrés Posada Saldarriaga

    OpenAIRE

    Uribe Vanegas, Camilo

    2015-01-01

    El presente trabajo pretende sustentar decisiones sobre la forma de abordar las dinámicas musicales en una pieza específica -- Esto se propone a partir de la sugerencia de consejos interpretativos dirigidos al músico violonchelista, para la interpretación de la obra “Movimiento” para chelo y piano del compositor colombiano Andrés Posada Saldarriaga -- Estos consejos se basan, a la vez, en un breve análisis de la pieza para sustentar así posibilidades dinámicas que enriquezcan la interpretació...

  1. Velocidad de descomposición de la hojarasca en diferentes sustratos de manglar en San Andrés Isla, Caribe colombiano

    Directory of Open Access Journals (Sweden)

    Omar Alfonso Sierra Rozo

    2007-01-01

    foliar del manglar en la acumulación de sedimentos es indispensable para estimar la estabilidad de los habitats costeros frente a los cambios del nivel del mar e impactos ocasionados por eventuales disturbios naturales. Con base a los resultados obtenidos y aquéllos de trabajos previos relacionados con las tasas de productividad de hojarasca en los mismos humedales de estudio, se propone un modelo básico conceptualcuantitativo de la dinámica producción-descomposición de hojarasca en San Andrés isla.

  2. El talento humano en beneficio de los usuarios del Centro de Salud Andrés de Vera del cantón Portoviejo.

    OpenAIRE

    Murillo Yulán, María Antonieta

    2014-01-01

    La investigación tuvo como objetivo determinar la situación del talento humano en beneficio de los servicios de salud que se brindan en el Centro de Salud de la parroquia Andrés de Vera conocido como LEA del cantón Portoviejo. Los métodos que se utilizaron fueron inductivo-deductivo, Histórico exploratorio, descriptivo, correlacional, documental, así también las hipótesis y variables; en el caso de la investigación de campo se preguntó a los usuarios externos.

  3. Quadrillages labyrinthiques: l’échiquier Caillois. Centenaire de la naissance de Roger Caillois, sous la direction de Valeria Emi Sgueglia et André-Alain Morello

    OpenAIRE

    Gardini, Michela

    2016-01-01

    Il volume si presenta come un omaggio per il centenario della nascita di Roger Caillois (1913) e raccoglie saggi di autori diversi in onore del celebre critico. Come suggerito dal titolo, l’opera di Caillois a cui tutti gli autori fanno riferimento è Cases d’un échiquier del 1970, un’opera mosaico presa come simbolo della molteplicità della ricerca epistemologica di Caillois. In apertura, dopo l’articolo introduttivo di André-Alain Morello (Une des récompenses de la rêverie, pp. 9-13), Enzo ...

  4. Desenvolvimento economico local em Porto Alegre e Santo Andre : um estudo sobre o papel das administrações municipais frente ao mainstream politico e academico conservador

    OpenAIRE

    Kleyferson Porto de Araujo

    2004-01-01

    Resumo:Esta dissertação tem por objetivo estudar como as políticas de desenvolvimento econômico local de dois importantes municípios brasileiros, governados por partidos de esquerda, estão se comportando frente ao mainstream político e acadêmico conservador, configurado pelo Banco Mundial. Para tanto, foram descritas e analisadas as políticas de desenvolvimento econômico local propostas pelo Banco Mundial e pelas administrações municipais de Porto Alegre e de Santo André. Inicialmente, são di...

  5. El Dioscórides de Andrés Laguna en los textos de Cervantes: de la materia medicinal al universo literario

    OpenAIRE

    Francisco López-Muñoz; Cecilio Álamo

    2007-01-01

    The literary works of Miguel de Cervantes have been widely studied from numerous points of view, including the medical one. In the present work, we defend the hypothesis that the Andrés Laguna version of Dioscorides was the source used by Cervantes in his literary passages related to therapeutic aspects, especially in relation to plants with medicinal properties. This book, a copy of which was in Cervantes’ private library, is the only medical treatise cited by the novelist in any of his writ...

  6. Nivel de consumo diario de frutas y verduras en escolares con sobrepeso y obesidad del primer y segundo grado de primaria de la Institución Educativa Particular San Andrés. Lima. Mayo 2011

    OpenAIRE

    Alfaro, katherine

    2013-01-01

    Objetivos: Determinar el nivel de consumo diario de frutas y verduras en escolares con sobrepeso y obesidad de primer y segundo grado de nivel primario de la IEP San Andrés. Diseño: Estudio descriptivo, transversal, observacional y prospectivo. Institución: Institución Educativa Particular San Andrés. Participantes: Veintisiete escolares con sobrepeso y 33 con obesidad, de primer y segundo grado de nivel primaria. Intervenciones: Aplicación de formato de frecuencia de consumo de frutas y verd...

  7. Bathyodontus mirus (Andrássy, 1956, first record of a representative of the suborder Bathyodontina (Nematoda, Mononchida in the Iberian fauna

    Directory of Open Access Journals (Sweden)

    Peña-Santiago, R.

    2010-12-01

    Full Text Available Bathyodontus mirus (Andrássy, 1956 Hopper & Cairns, 1956, collected in sand dunes of SW Iberian peninsula, is studied. Description, measurements and illustrations (LM pictures are provided. Iberian specimens are briefly compared to other known populations of the species. And a compendium of Bathyodontus species, including a key to their identification, is also given. This is the first record of a representative of the nematode suborder Bathyodontina in the Iberian-Balearic range and in the Mediterranean region.Se estudia la especie Bathyodontus mirus (Andrássy, 1956 Hopper y Cairns, 1956, recolectada en dunas de arena en el suroeste peninsular. Se presentan una descripción, medidas e ilustraciones (fotografías con microscopía óptica. Los ejemplares ibéricos se comparan brevemente con otras poblaciones conocidas de la misma especie. Y se ofrece un compendio de las especies del género Bathyodontus, incluida una clave para su identification. Se trata de la primera cita de un miembro del suborden Bathyodontina en el ámbito Ibero-balear y en la región Mediterránea.

  8. Neurological Impact of World War I on the Artistic Avant-Garde: The Examples of André Breton, Guillaume Apollinaire and Blaise Cendrars.

    Science.gov (United States)

    Bogousslavsky, Julien; Tatu, Laurent

    2016-01-01

    World War I erupted at a time when artistic avant-gardes were particularly thriving across Europe. Young poets, writers, painters and sculptors were called to arms or voluntary enrolled to fight, and several of them died during the conflict. Among others, it dramatically changed their creative output, either through specific wounds or through personal encounters and experiences. These individual events then significantly modified the course of the literary and artistic avant-garde movements. Three particularly illustrative examples of avant-garde French poets are presented here: André Breton (1896-1966), Guillaume Apollinaire (1880-1918) and Blaise Cendrars (1887-1961). The deep source of the surrealist movement can indeed be found in André Breton's involvement as an auxiliary physician with critical interest in neuropsychiatry, which caused him to discover automatic writing. Guillaume Apollinaire's right temporal subdural hematoma strongly modified his emotional state and subsequent artistic activities. Alternatively, after losing his right, writing hand, Blaise Cendrars not only substituted it with a phantom but also rapidly switched from poetry to novels after he learnt to write with his left hand. © 2016 S. Karger AG, Basel.

  9. Precipitation, density, and population dynamics of desert bighorn sheep on San Andres National Wildlife Refuge, New Mexico

    Science.gov (United States)

    Bender, L.C.; Weisenberger, M.E.

    2005-01-01

    Understanding the determinants of population size and performance for desert bighorn sheep (Ovis canadensis mexicana) is critical to develop effective recovery and management strategies. In arid environments, plant communities and consequently herbivore populations are strongly dependent upon precipitation, which is highly variable seasonally and annually. We conducted a retrospective exploratory analysis of desert bighorn sheep population dynamics on San Andres National Wildlife Refuge (SANWR), New Mexico, 1941-1976, by modeling sheep population size as a function of previous population sizes and precipitation. Population size and trend of desert bighorn were best and well described (R 2=0.89) by a model that included only total annual precipitation as a covariate. Models incorporating density-dependence, delayed density-dependence, and combinations of density and precipitation were less informative than the model containing precipitation alone (??AlCc=8.5-22.5). Lamb:female ratios were positively related to precipitation (current year: F1,34=7.09, P=0.012; previous year: F1,33=3.37, P=0.075) but were unrelated to population size (current year. F1,34=0.04, P=0.843; previous year: F1,33 =0.14, P=0.715). Instantaneous population rate of increase (r) was related to population size (F1,33=5.55; P=0.025). Precipitation limited populations of desert bighorn sheep on SANWR primarily in a density-independent manner by affecting production or survival of lambs, likely through influences on forage quantity and quality. Habitat evaluations and recovery plans for desert bighorn sheep need to consider fundamental influences on desert bighorn populations such as precipitation and food, rather than focus solely on proximate issues such as security cover, predation, and disease. Moreover, the concept of carrying capacity for desert bighorn sheep may need re-evaluation in respect to highly variable (CV =35.6%) localized precipitation patterns. On SANWR carrying capacity for desert

  10. Miranda: cultura griega, estudios clásicos, relación con Andrés Bello

    Directory of Open Access Journals (Sweden)

    Miguel Castillo Didier

    2005-12-01

    Full Text Available Francisco de Miranda (1750-1816, precursor, herói e mártir da Independência da América Hispânica, estudou a língua grega e reuniu uma vasta biblioteca, com mais de 170 autores gregos. A idéia de liberdade para a américa espanhola surgiu nele em 1781, ligada a sua profunda admiração pela Grécia, na qual nasceu a liberdade. Aí está porque em sua longa viagem através da Europa, em 1786, apesar das ameaças e dos perigos, ele viajou para a Grécia, que gemia sob a dominação otomana. Ele desejava conhecer os lugares onde haviam nascido as idéias de liberdade e democracia, onde um pequeno povo havia vencido um gigantesco império absolutista. Miranda visitou o Pireu, Atenas, Corinto, Salamina, Maratona e depois Esmirna e Constantinopla. Escreveu um jornal muito interessante de sua viagem à Grécia. Em 1792, Miranda serviu na França, quando a Revolução Francesa ainda não tinha abandonado os ideais libertários. Lá, Miranda defendeu os princípios republicanos e a divisão dos poderes, invocando não Montesquieu, mas o exemplo da Grécia antiga. Pedro Grase iniciou com Miranda seu estudo da tradição humanista na América Latina e prossegue com Andrés Bello (1781-1816, o grande sábio que estudou a língua grega na biblioteca de Miranda, em Londres, e que se tornou latinista e helenista. Bello compartilha de sua convicção de que o estudo do latim e do grego e da cultura clássica está na base de toda a cultura sólida.

  11. Development and recent activity of the San Andrés landslide on El Hierro, Canary Islands, Spain

    Science.gov (United States)

    Klimeš, Jan; Yepes, Jorge; Becerril, Laura; Kusák, Michal; Galindo, Inés; Blahut, Jan

    2016-05-01

    Extremely voluminous landslides with a long run-out (also known as megalandslides) on oceanic volcanic islands are infrequent denudational processes on such islands. At the same time, they represent a major geological hazard that must be looked into to avoid negative consequences for the inhabitants of these islands. Their occurrence can be related to periods of intense seismo-volcanic activity, similar to that which occurred on El Hierro Island over 2011-2012. Landslides on volcanic islands are studied using onshore and offshore geological, geophysical and geomorphological records, considering their unique triggering conditions (e.g. lava intrusions, eruptive vents, magma chamber collapses). Previous work has pointed out similarities between specific cases of landslides on volcanic islands and deep-seated gravitational slope deformations (DSGSDs) which are typical in high mountain settings. Nevertheless, the methodological approaches and concepts used to investigate DSGSDs are not commonly applied on volcanic islands studies, even though their use may provide new information about the development stage, recent movements and future hazards. Therefore, this approach for studying the San Andrés landslide (SAL) on El Hierro (Canary Islands) has been developed applying a detailed morphological field mapping, an interpretation of digital elevation models, structural measurements, kinematic testing, and a precise movement monitoring system. The acquired information revealed a strong structural influence on the landslide morphology and the presence of sets of weakened planes acting as the sliding surfaces of the SAL or secondary landslides within its body. The presence of secondary landslides, deep erosive gullies, coastal cliffs and high on-shore relative relief also suggests a high susceptibility to future landslide movement. Direct monitoring on the landslide scarps and the slip plane, performed between February 2013 and July 2014, using an automated optical

  12. Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas.

    Science.gov (United States)

    Iwasaki, Takeshi; Matsushita, Michiko; Nonaka, Daisuke; Kuwamoto, Satoshi; Kato, Masako; Murakami, Ichiro; Nagata, Keiko; Nakajima, Hideki; Sano, Shigetoshi; Hayashi, Kazuhiko

    2015-02-01

    Merkel cell polyomavirus (MCPyV) integrates monoclonally into the genomes of approximately 80% of Merkel cell carcinomas (MCCs), affecting their clinicopathological features. The molecular mechanisms underlying MCC development after MCPyV infection remain unclear. We investigated the association of MCPyV infection with activation of the Akt/mammalian target of rapamycin (mTOR)/4E-binding protein 1 (4E-BP1) signaling pathway in MCCs to elucidate the role of these signal transductions and to identify molecular targets for treatment. We analyzed the molecular and pathological characteristics of 41 MCPyV-positive and 27 MCPyV-negative MCCs. Expression of mTOR, TSC1, and TSC2 messenger RNA was significantly higher in MCPyV-negative MCCs, and Akt (T308) phosphorylation also was significantly higher (92% vs 66%; P = .019), whereas 4E-BP1 (S65 and T70) phosphorylation was common in both MCC types (92%-100%). The expression rates of most other tested signals were high (60%-100%) and not significantly correlated with MCPyV large T antigen expression. PIK3CA mutations were observed more frequently in MCPyV-positive MCCs (6/36 [17%] vs 2/20 [10%]). These results suggest that protein expression (activation) of most Akt/mTOR/4E-BP1 pathway signals was not significantly different in MCPyV-positive and MCPyV-negative MCCs, although these 2 types may differ in tumorigenesis, and MCPyV-negative MCCs showed significantly more frequent p-Akt (T308) activation. Therefore, certain Akt/mTOR/4E-BP1 pathway signals could be novel therapeutic targets for MCC regardless of MCPyV infection status. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Jõekääru Jazz täitis eesmärgi nii korraldajate, esinejate kui publiku poolelt / Allan Liik, Hedvig Hanson, Andre Maaker, Ain Agan...[jt.] ; foto ja küsitl. Kaire Tensuda

    Index Scriptorium Estoniae

    2007-01-01

    Jõekääru Jazz'ile järgneval nädalal tõi ürituse peakorraldaja Allan Liik toimetusse seal esinenud muusikud. Vestlusringis olid: Allan Liik, Hedvig Hanson, Andre Maaker, Ain Agan, Raivo Tafenau ja Sergio Bastos

  14. Antropoloogiline Holland / Andres Kõnno

    Index Scriptorium Estoniae

    Kõnno, Andres

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivali filme - Hollandi mängufilmid "Putini ema" ("Poetin's Mama") : režissöör Ineke Smits : 2003 ; "Shouf-Shouf Habibi" : režissöör Albert Ter Heerdt : 2004 ; "Üks ilus päev" ("Het is een schone dag geweest") : režissöör Jos de Putter : 1993 ; "Grimm" : režissöör Alex van Warmerdam : 2003

  15. DVD / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Kolme USA mängufilmi DVD-de lühitutvustused : Spike Lee "Keegi seestpoolt" ("Inside Man"), Jonathan Liebesmani "Texase mootorsaemõrvad: Algus" ("The Texas Chainsaw Massacre : The Beginning"), Allen Coulteri "Hollywoodland"

  16. Kolleegist parem / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2006-01-01

    Eesti Sisearhitektide Liidu aastapreemiad 2005: parima ühiskondliku interjööri preemia võitis Pääsküla raamatukogu (Katrin Kaevats, Urmas Muru, Peeter Pere), näitusekujunduse preemia sai Maanteemuuseum (Krista Lepland, Malle Jürgenson, Tea Tammelaan, OÜ Laika, Belka & Strelka), ajaloolise interjööri preemia läks renoveeritud Estonia teatrile (Juta Lember, Aulo Padar), publitsistikapreemia sai Leila Pärtelpoja raamat "Pööningul", teise ühiskondliku ruumi preemia võitis TTP ärihoone Pirital (Meelis Press). Kommentaar Tiina Jõgedalt

  17. Plaadid / Andre Pichen

    Index Scriptorium Estoniae

    Pichen, Andre

    2006-01-01

    Uutest heliplaatidest Volbeat "The Strength, The Sound, The Songs", Soulwax "Nite Versions", Praful "Pyramid In Your Backyard", Eminem "Curtain Call", "Bossa 'n'' Stones", Mr Oizo "Moustache", Westlife "Face To Face"

  18. Arvustused / Andres Põllu

    Index Scriptorium Estoniae

    Põllu, Andres

    2000-01-01

    Uute heliplaatide Eric Clapton & B.B. King, B. B. "Riding with the King", Dreamphish "It Is I", Deftones "White Pony", Einstürzende Neubauten "Silence Is Sexy", Steve Earle "Transcendental Blues", The Filth And The Fury - A Sex Pistols Film, Cafe Del Mar tutvustus

  19. Retrofuturistlik tulevik / Andres Lõo

    Index Scriptorium Estoniae

    Lõo, Andres, 1978-

    2012-01-01

    17. septembril NO99 teatris esietendunud kolme teatri - NO99, Münchner Kammerspiele, Lyric Hammersmith Theatre - koostöös valminud lavastusest "Three Kingdoms" ("Kolm kuningriiki"), teksti autor Simon Stephens, lavastaja Sebastian Nübling

  20. Kohtumine Oslos / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2009-01-01

    Autor kommenteerib Oslos toimunud Tšetšeenia eksiilvalitsuse juhi Ahmed Zakajevi ning praeguse Tšetšeenia valitseja Ramzan Kadõrovi esindaja ja parlamendijuhi Duhhvahha Abdurahmanovi kohtumist. Versioonid tulevikuks

  1. Julgus kahelda / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2004-01-01

    Okupatsioonide muuseumist, 7. "Europani" arhitektuurikonkursil äramärgitud tööst "Alvar" (autoreiks Londonis töötavad arhitektid Eike Sindlinger, Ulrike Steven, Gareth Morris büroost 7-degrees), mis püüab positiivselt sekkuda Tallinna Lasnamäe praegusesse hoonestusse, võimalustest teha sotsiaalselt tundlikku arhitektuuri

  2. Objekt 2011 / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2011-01-01

    Installatsioon "Objekt nr. 2011" Tallinnas Vabaduse väljakul 27.02.-20.03.2011. Austria arhitektide rühmituse Haus-Rucker-Co installatsioon "Oaasi nr. 7" 5. Documenta näitusel Kasselis 1972. aastal

  3. Klounaad paukpadrunitega / Andres Ermel

    Index Scriptorium Estoniae

    Ermel, Andres

    2008-01-01

    Kaksikvendadest näitekirajnikest Peter ja Anthony Shafferist. Viimase menunäidendist "Nuuskur" ("Sleuth") ja selle järgi 1972. a. Joseph L. Mankewiczi poolt tehtud filmist ning Kenneth Branaghi 2007. a. uusversioonist lühidalt

  4. Kõnnitee kindlusesse / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    1998-01-01

    Arhitektid José Martinez Lapena ja Elias Torres Tur ääristasid siksakina mäekülge mööda Castelldefelsi kindlusse viiva jalakäijaste tee Barcelonas raudbetooni ja sakilise roostevärvi Corten terasega

  5. Andre scener fra Afghanistan

    DEFF Research Database (Denmark)

    Serritzlev, Jeanette

    2010-01-01

    Filmen 'Armadillo' viser, at indsatsen i Afghanistan er formålsløs. At det ikke nytter. At drengene er storforbrugere af cola og porno, og at afghanerne synes, at vi skal tage hjem. At soldaterne har sjove film på deres computere, kan ikke provokere mig. Det kan til gengæld et ensidigt og fortegnet...

  6. Parandage finantstee! / Andres Velasco

    Index Scriptorium Estoniae

    Velasco, Andres

    2001-01-01

    Harvardi ülikooli juures tegutseva Kennedy valitsuskooli majandusprof. väidab, et rahvusvaheline finantssüsteem pankrotistab keskmise sissetulekuga riike. Majanduskriisis Argentina kaks võimalust. Majanduskriisi põhjused

  7. Notes to the recent reissue of the book Poems of the mothers of Gabriela Mistral With illustrations by André Racz

    Directory of Open Access Journals (Sweden)

    Mónica R. Ravelo García

    2017-04-01

    Full Text Available The book The Mothers’ Poems, combining the verses of Gabriela Mistral and drawings of the artist Andre Racz, has been reissued by Ediciones Radio Universidad de Chile with the support of the National Council for Culture and the Arts (CNCA of the Government of Chile in 2015. This is the third edition of the poems and the second in which Racz’s images are included, since it was published for first time in 1950. The theme of motherhood, women, fears and strengths are masterfully described by a woman who could never conceive but devotedly loved children and empathized with women. With such delivery, with his strokes Racz described the delicate and sensitive world of the pregnant woman. Both artists joined in the realization of this book as an expression of love and human solidarity.

  8. André Raymond, Égyptiens et Français au Caire, 1798-1801, Le Caire, IFAO, 1998, 391 p.

    Directory of Open Access Journals (Sweden)

    Jean-Charles Depaule

    2005-03-01

    Full Text Available La Description établie par les savants que Bonaparte avait emmenés en Égypte offre, on le sait, un riche tableau, d'autant plus précieux qu'il fixe un moment charnière : dans les décennies qui suivront le pays entrera dans une ère nouvelle, celle de sa "modernisation" et de la construction d'un État progressivement indépendant. Procédant par coupes, la vision de la Description était statique. André Raymond, dès le premier chapitre de son livre, anime en quelque sorte le monde enregistré par l...

  9. Identidades ambientales, un caso comparativo entre el Trapecio amazónico y el Archipiélago de San Andrés

    Directory of Open Access Journals (Sweden)

    Pablo De La Cruz

    2014-01-01

    Full Text Available A partir de la definición de identidad ambiental, el artículo compara los procesos de transformación identitaria que han tenido lugar en el Trapecio amazónico colombiano y en el Archipiélago de San Andrés, por cuanto son dos casos de redefinición histórica de la etnicidad con referencia al medio geográfico, al encuentro con la colombianidad, a la agudización del discurso y a las tensiones que los capitales y los agentes institucionales generan en torno a lo tradicional. Se analiza el creciente turismo, la influencia de las agencias de cooperación y sus efectos en el desplazamiento de lo sagrado hacia una “cultura teatral”.

  10. Space schemes of ecological zonation and morphology of the atolls lagoons and reef complex of an oceanic archipelago of the Caribbean: San Andres and Providence (Colombia)

    International Nuclear Information System (INIS)

    Diaz M, Juan Manuel

    2005-01-01

    The oceanic atolls and reef-complexes of the Archipelago of San Andres and Providencia exhibit semi-enclosed to rather open lagoon basins, where various characteristic bottom habitats occur. Certain areas of the lagoon floor are covered by sediments, being in some settings vegetated by algae or sea grass, and other areas by coralline framework of different types according to the composition and dominance of coral species and to their morphology and level of reef development. This study seeks to determine the spatial distribution patterns of lagoon bottom habitats based on the analysis of gradients of most relevant physical factors. Patterns in the occurrence and abundance of most habitats became evident in relation with wave-energy level, water depth, and the occurrence of islands. Some morphological reef types are oriented in a preferential direction and show spatial arrangements of development that are presumably related to prevailing current speed and direction and wave exposure

  11. Laboratorios Andrómaco: Origins of the First Subsidiary of a Spanish Pharmaceutical Multinational in the United States (1928–1946

    Directory of Open Access Journals (Sweden)

    Paloma Fernández Pérez

    2016-07-01

    Full Text Available Laboratorios Andrómaco was a Spanish pharmaceutical company that opened a commercial subsidiary in the United States in the early months of 1929. It was located right in the heart of Manhattan, at 11 West 47th Street, in front of the New York Public Library. Despite the Wall Street crash, it remained open until 1946. The owner was the pharmacist-entrepreneur Fernando Rubió Tudurí (1900–1994. It was the first foreign direct investment made by a Spanish pharmaceutical multinational in the United States, using a maquila-style operation to export Spanish products made in the USA to Central American markets. Nothing has been published about this until now. Only interviews with Enrique and Mercè Rubió Boada (son and daughter of Fernando Rubió, digitalized sources from the company held by the Fundació Rubió Tudurí in Mahón, Minorca, and hard-to-access secondary sources have made the recovery of this history possible. The company closed its doors in the US and expanded in South American markets after World War II, but the short history of their investment in the United States reveals the potential and international capabilities of Spanish pharmaceutical companies before the Spanish Civil War. Moreover, it reveals how the Spanish Civil War was a disaster for millions of people but in some special cases it became an opportunity for companies in the science industries. Few pharmaceutical firms like Andrómaco, with entrepreneurs, resources, and a long-term vision, took the decision to invest in the most profitable (though also the most difficult market for pharmaceutical products in the world: the United States. Andrómaco was created in Barcelona in 1923 by two scientist-entrepreneurs (Raul Roviralta and Fernando Rubió Tudurí. A nutritional product called Glefina (made with Norwegian cod oil from Ålesund and sugar brought the small firm considerable success in sales in Spain in the mid-1920s. Making use of impressive networks (with the

  12. Andrés del Río, Antonio del Castillo y José G. Aguilera en el desarrollo de la ciencia mexicana del siglo XIX

    Directory of Open Access Journals (Sweden)

    Uribe Salas, José Alfredo

    2006-08-01

    Full Text Available This article analyzes the intrinsic relation between education and science in the process of institutionalization of mineralogy and geology in nineteenth-century Mexico. It focuses on the intellectual leadership of three men of sciences in the modernization and professionalization of geology’s curricula. These were: Andrés Manuel del Río, Antonio del Castillo y José G. Aguilera. The work of these men represents the human foundation of the process of institutionalization and professionalization of Earth Sciences in Mexico: from the Royal Mining Seminar, to the Mining School and the National School of Engineering, to the National Institute of Geology, the latter the immediate antecedent of the modern Institute of Geology at the National Autonomous University of Mexico (UNAM.

    En el artículo se analiza la relación intrínseca entre educación y ciencia en el proceso de institucionalización de la mineralogía y la geología en México del siglo XIX. Destacamos el liderazgo intelectual de tres hombres de ciencia que desempeñaron un esfuerzo articulador en la modernización de los planes de estudio y profesionalización de la geología mexicana. Ellos son: Andrés Manuel del Río, Antonio del Castillo y José G. Aguilera. El trabajo de estos tres hombres representa el soporte humano del proceso de institucionalización y profesionalización de las Ciencias de la Tierra, primero a través del Real Seminario de Minería, pasando por la Escuela de Minería y la Escuela Nacional de Ingenieros, para terminar en el Instituto de Geológico Nacional, antecedente directo del actual Instituto de Geología de la Universidad Nacional Autónoma de México.

  13. Corrupción y regeneración: Víctor Andrés Belaunde y «La crisis presente»

    Directory of Open Access Journals (Sweden)

    Santiváñez Vivanco, Martín

    2014-04-01

    Full Text Available Víctor Andrés Belaunde, one of the most relevant thinkers of Latin American Arielism, held that it was necessary to combine institutional design with a regeneration of values, as a solution to the political crisis that Peru was experiencing. Thus, the combination of institutional design and axiological or ethical vitalism created a holistic approach that introduced into the public debate a vision of integral development in which the fight against corruption and institutional problems could be addressed, in a complementary way, from an ethical perspective. This dimension served to strengthen the construction of an inclusive State, one of the political objectives of the Arielian generation.Víctor Andrés Belaunde, uno de los pensadores más relevantes del arielismo latinoamericano, sostuvo la necesidad de combinar el diseño institucional con una regeneración valorativa como remedio a la crisis política que atravesaba el Perú. Así, la combinación de diseño institucional y vitalismo axiológico configuró un enfoque sintético que introdujo en la discusión pública una visión de desarrollo integral en el que la lucha contra la corrupción y los problemas institucionales podían ser abordados, de manera complementaria, desde una perspectiva ética. Tal dimensión servía para fortalecer la construcción de un Estado inclusivo, uno de los objetivos políticos de la generación arielista.

  14. Vigencia de la filosofía de Kant en dos expresiones actuales de la inteligencia filosófica en América Latina: Arturo Andrés Roig y Franz J. Hinkelammert The Force of Kant's Philosophy in Two Present Expressions of the Philosophical Intelligence in Latin America: Arturo Andrés Roig y Franz J. Hinkelammert

    Directory of Open Access Journals (Sweden)

    Yamandú Acosta

    2006-12-01

    Full Text Available Al cumplirse doscientos años de la muerte de Immanuel Kant 2004, considerar la vigencia de su pensamiento filosófico, se constituyó en un imperativo categórico, para quienes nos inscribimos en la tradición de la filosofía occidental. En cumplimiento del mismo, el texto que se presenta se ocupa de la vigencia de la filosofía del filósofo de Königsberg a través de la consideración de dos expresiones de la inteligencia filosófica en América Latina: Arturo Andrés Roig (Mendoza, Argentina, 1922 y Franz J. Hinkelammert (Emsdetten, Alemania,1931. Los programas de investigación en curso de los dos autores elegidos, en el abordaje y desarrollo de distintos tópicos, proceden argumentativamente desde, contra y más allá de Kant, exhibiendo una singular vigencia de su filosofía al interior de los mismos. En el pensamiento de Arturo Andrés Roig, los tópicos de referencia que se consideran son: la normatividad del pensamiento filosófico, la filosofía de la historia, la fundamentación de una moral emergente y la fundamentación de una estética motivacional. De la producción teórica de Franz J. Hinkelammert, se presentan: la crítica a la razón utópica y el realismo político, la crítica trascendental de los marcos categoriales de los pensamientos sociales, la trascendentalidad del sujeto y el problema del universalismo ético en la tensión entre la ética de la responsabilidad y la ética de principios. Surge de la consideración de los asuntos enumerados, que en relación al universalismo abstracto de Kant, estos dos exponentes de la inteligencia filosófica en América Latina, convergen en la fundamentación de un universalismo concreto.Currency of Kant's philosophy in two recent expressions of the philosophical intelligence in Latin America: Arturo Andrés Roig and Franz J. Hinkelammert. When it is twohundred years of Immanuel Kant´s death (2004, to consider the currency of his philosophical thought means a categorial must

  15. Haṭhapradīpikā

    DEFF Research Database (Denmark)

    Olesen, Bjarne Wernicke; Einarsen, Silje Lyngar; , .

    ), prāṇāyāma (åndedrætsteknikker), mudrā (yogiske teknikker) og samādhi (meditative indsigter). Dertil er HYP et encyklopædisk værk (formodentligt sammensat af mere end 20 forskellige yogaskrifter) fra haṭhayogaens klassisk-formative fase, hvorfor værket tillige udgør en forståelsesnøgle til yoga, tantra og...

  16. Identificación de mutaciones en el gen para el receptor de andrógenos por medio de la técnica SSCP en pacientes con insensibilidad androgénica completa

    Directory of Open Access Journals (Sweden)

    M. Escaf

    2001-07-01

    Full Text Available El Síndrome de Insensibilidad Androgénica (SIA es causado por defectos del gen para elReceptor de Andrógenos (RA, el síndrome presenta 3 fenotipos: Completa (SIAC, el fenotipoes femenino, Parcial (SIAP donde se puede presentar ambigüedad genital y Mínima (SIAMque se presenta con infertilidad en pacientes con fenotipo masculino.

  17. Epidemiología de la enfermedad de Chagas en el municipio Andrés Eloy Blanco, Lara, Venezuela: infestación triatomínica y seroprevalencia en humanos Epidemiology of Chagas disease in Andrés Eloy Blanco, Lara, Venezuela: triatomine infestation and human seroprevalence

    Directory of Open Access Journals (Sweden)

    Claudina Rodríguez-Bonfante

    2007-05-01

    Full Text Available Se realizó un despistaje serológico y recolección de vectores en cuatro comunidades rurales del municipio Andrés Eloy Blanco, Estado Lara, Venezuela. La muestra fue escogida en forma sistemática y aleatoria basada en conglomerados familiares. Se muestrearon 869 habitantes para determinar anticuerpos anti-Trypanosoma cruzi y anti-Leishmania sp. por inmunofluorescencia indirecta, aceptando como positivo diluciones > a 1:32 para anticuerpos anti-T. cruzi no reactivos para antígenos de Leishmania sp., obteniendo una frecuencia de anticuerpos en la muestra de 6,9% (n = 60; de los cuales 46,66% son femeninos, 53,33% masculinos y 60% mayores de 40 años. Se observó que 5 (8,33% de los seropositivos eran menores de 10 años y 10 (16,66% menores de 20 años. Rhodnius prolixus y Panstrongylus geniculatus fueron los triatominos capturados, con índice de infestación de 1,9 y 10,54%, índice de colonización, del 0 y 18,18% en las viviendas infestadas e índice de infección a T. cruzi del 20 y 5,07%, respectivamente. Los resultados sugieren que existe una transmisión activa de la enfermedad de Chagas en el Municipio Andrés Eloy Blanco en las últimas dos décadas y que P. geniculatus está substituyendo a R. prolixus como vector de la enfermedad de Chagas.A seroepidemiological survey and vector captures were performed in four rural communities in Andrés Eloy Blanco, Lara State, Venezuela. Systematic random sampling was based on family clusters, with samples drawn from 869 individuals to determine anti-Trypanosoma cruzi and anti-Leishmania sp. antibodies by indirect immunofluorescence. Positive individuals were defined as > 1:32 for anti-T. cruzi antibody and non-reactive to Leishmania sp. antigen, revealing an antibody frequency of 6.9% (n = 60, of whom 46.66% were females and 53.33% males and 60% were over 39 years of age. Some 5 (8.33% seropositive individuals were under 10 years of age and 10 (16.66% under 20 years. Rhodnius prolixus and

  18. Narcotráfico, violencia y crisis social en el Caribe insular colombiano: El caso de la isla de San Andrés en el contexto del Gran Caribe Drug Traffiking, Violence and the Social Crisis in Colombian Caribbean Islands: The Case of San Andrés Island in the Context of the Great Caribbean

    Directory of Open Access Journals (Sweden)

    Silvia Mantilla

    2011-06-01

    Full Text Available El presente artículo tiene por objetivo presentar un diagnóstico preliminar de la magnitud del tráfico de drogas, sus dinámicas, modalidades, y las condiciones sociales y económicas que favorecen el desarrollo de este negocio ilegal en la isla de San Andrés (Colombia. El análisis se desarrolla, no obstante, en el marco de la condición histórica y natural de "zona de tránsito" de drogas, armas y otros recursos ilegales, que se le atribuye a la región del Gran Caribe, entendida como un continuo geográfico, histórico y cultural en el que se observan patrones comunes en materia de amenazas a la seguridad, la geopolítica de las relaciones con Estados Unidos y los efectos sociales y económicos derivados del flagelo del narcotráfico. En este sentido, el caso de la isla de San Andrés (Colombia se examina más como parte de la dinámica insular gran caribeña que como parte de las tendencias propias del negocio en la Colombia continental, lo que permite, sin embargo, establecer las conexiones entre ambos espacios regionales -el insular y el continental- y, a la vez, evaluar el impacto regional del fenómeno a partir de las conexiones ilegales que desde el archipiélago se establecen con algunos países vecinos del Gran Caribe. Finalmente, se sostiene la hipótesis de que el fenómeno del narcotráfico se instala en la isla como resultado de factores geohistóricos, culturales y socioeconómicos que en conjunto han determinado la participación activa de distintos sectores de la sociedad en este negocio ilegal.The objective of thispaper is to present a preliminary diagnosis of the magnitude, dynamics, and modalities of drug trafficking, together with the social and economic conditions that support the development of this illegal activity in the island of San Andres (Colombia. Analysis is conducted within a framework that identifies this trafficking zone as a natural and historic corridor for trade in weapons, drugs, and other illicit

  19. Proyecto de un servicio funcional a prestar en una biblioteca universitaria: “El Servicio de Información Departamental” de la Biblioteca Max von Buch (Universidad de San Andrés = Project of a functional service to be provided in an university library: "The Departmental Information Service" of the Max von Buch Library (Universidad de San Andrés

    Directory of Open Access Journals (Sweden)

    Moira Guppy

    2001-06-01

    Full Text Available Este trabajo –elaborado para el Seminario “La organización de los Servicios al Público en la Biblioteca” (UBA, 1998- describe el proyecto de un servicio a desarrollar en la Biblioteca Max von Buch de la Universidad de San Andrés. El “Servicio de Información Departamental” ofrecerá a los docentes e investigadores acceso a los recursos disponibles dentro de su área temática (Internet, bases de datos, índices de artículos de publicaciones periódicas, revistas en texto completo, series estadísticas, etc. Estará elaborado en dos formatos: un cd-rom actualizado periódicamente, y una página Web en línea especialmente diseñada. Con la implementación de este servicio se logrará un gran ahorro de tiempo en la búsqueda, análisis, tratamiento y difusión de la información destinada a la investigación académica = This paper –presented at the seminary “Public Services Organization at the Library”- describes a project to be developed at the Max von Buch Library, Universidad de San Andrés. The “Academic Information Service” would be design to provide access to researchers and faculty to all the resources available whithin each discipline and research area in the Internet, databases, periodical indexes, full text periodicals, statistical data, etc. They will gain access to it from a cd-rom which would be updated periodically, and a web page specially designed. The implementation of this project would provide faculty with qualified information along with considerable time saving in their researches.

  20. Pasado, historia y primera persona: el uso del archivo en ‘Fotografías’ de Andrés di Tella

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    Agustín Díez Fischer

    2016-09-01

    Full Text Available En los estudios sobre la filmografía del documentalista argentino Andrés Di Tella (1958 es recurrente la referencia a la centralidad de la narración en primera persona, al director como investigador y al uso de recursos ensayísticos para articular la  memoria personal y la historia argentina. En esta dirección, analizaremos su película Fotografías como un ensayo sobre el archivo y sus dispositivos en función de reconsiderar las relaciones entre el repositorio público y el privado, entre lo personal y lo nacional y entre el pasado y el presente. Desde este punto de vista, si las relaciones con el archivo fueron fundamentales para la memoria de los sucesos traumáticos de la dictadura argentina, este film permite pensar que esas investigaciones permearon y fueron permeables a ensayos cinematográficos que no se focalizaron directamente en la elaboración de ese pasado histórico.

  1. Terre-Neuve ou la carte éclatée d'après le «Grand Insulaire» d'André Thevet

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    Frank LESTRINGANT

    1987-09-01

    Full Text Available Les deux cartes relatives à Terre-Neuve, représentée comme un archipel, que l'on trouve dans le Grand Insulaire inachevé du cosmographe André Thevet (circa, 1586, sont un bon témoignage des errements en partie calculés auxquels se prêtait la cartographie à l'époque des Grandes Découvertes. Pour vaincre des contraintes techniques d'une part, telles que la nécessité du montage entre des données disparates, et pour affirmer d'autre part le dessein d'une entreprise de conquête, le cosmographe — ou géographe universel — est amené à truquer, selon les règles de l'art, un document composite, prélevé à l'origine sur le planisphère de Mercator et augmenté d'informations venues des routiers portulans. Une île inédite, qui porte le nom de Thevet, a pour fonction de signer le tout.

  2. Development and validation of analytical methodology for determination of polycyclic aromatic hydrocarbons (PAHS) in sediments. Assesment of Pedroso Park dam, Santo Andre, SP

    International Nuclear Information System (INIS)

    Brito, Carlos Fernando de

    2009-01-01

    The polycyclic aromatic hydrocarbons (PAHs), by being considered persistent contaminants, by their ubiquity in the environment and by the recognition of their genotoxicity, have stimulated research activities in order to determine and evaluate their sources, transport, processing, biological effects and accumulation in compartments of aquatic and terrestrial ecosystems. In this work, the matrix studied was sediment collected at Pedroso Park's dam at Santo Andre, SP. The analytical technique employed was liquid chromatography in reverse phase with a UV/Vis detector. Statistics treatment of the data was established during the process of developing the methodology for which there was reliable results. The steps involved were evaluated using the concept of Validation of Chemical Testing. The parameters selected for the analytical validation were selectivity, linearity, Working Range, Sensitivity, Accuracy, Precision, Limit of Detection, Limit of quantification and robustness. These parameters showed satisfactory results, allowing the application of the methodology, and is a simple method that allows the minimization of contamination and loss of compounds by over-handling. For the PAHs tested were no found positive results, above the limit of detection, in any of the samples collected in the first phase. But, at the second collection, were found small changes mainly acenaphthylene, fluorene and benzo[a]anthracene. Although the area is preserved, it is possible to realize little signs of contamination. (author)

  3. Natural factors and antropics and their relationship with the density of colonies of Melipona beecheii in five vegetable formations of the valley San Andres

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    Katiuska Ravelo Pimentel

    2014-12-01

    Full Text Available It is evaluated the influence of natural factors and antropics on the density of colonies of Melipona beecheii in forest five vegetable formations of the solid one of the valley San Andrés, through surveys to residents and workers of the area, as well as the observations and samplings carried out in the studied vegetable formations. The following factors were studied: rocosity, vegetable covering, flourished plants, height of the entrance hole and the man's activity; being determined that the density of beehives has been affected fundamentally by factors antropics, having this its biggest incidence in the gallery forests, being this the most affected one. The pruning of trees, the naturalness of the forests and their access affect the population's conservation considerably under natural conditions, what demonstrates that this it is the main factor that locates in extirpation danger to the species in the study area. In turn the density of colonies keeps direct relationship with the other analyzed factors, since the same ones depend on the trees for the location of its nests, of the time in that the plants flourish for its feeding and of the holes found in the rocks, so much for the making of its colonies like it stops its establishment and reproduction.

  4. Monsters and the case of L. Joseph: André Feil's thesis on the origin of the Klippel-Feil syndrome and a social transformation of medicine.

    Science.gov (United States)

    Belykh, Evgenii; Malik, Kashif; Simoneau, Isabelle; Yagmurlu, Kaan; Lei, Ting; Cavalcanti, Daniel D; Byvaltsev, Vadim A; Theodore, Nicholas; Preul, Mark C

    2016-07-01

    André Feil (1884-1955) was a French physician best recognized for his description, coauthored with Maurice Klippel, of patients with congenital fusion of cervical vertebrae, a condition currently known as Klippel-Feil syndrome. However, little is known about his background aside from the fact that he was a student of Klippel and a physician who took a keen interest in describing congenital anomalies. Despite the relative lack of information on Feil, his contributions to the fields of spinal disease and teratology extended far beyond science to play an integral role in changing the misguided perception shrouding patients with disfigurements, defects, deformities, and so-called monstrous births. In particular, Feil's 1919 medical school thesis on cervical abnormalities was a critical publication in defying long-held theory and opinion that human "monstrosities," anomalies, developmental abnormalities, and altered congenital physicality were a consequence of sinful behavior or a reversion to a primitive state. Indeed, his thesis on a spinal deformity centering on his patient, L. Joseph, was at the vanguard for a new view of a patient as nothing less than fully human, no matter his or her physicality or appearance.

  5. Energy world governance. Review of the conference which was held at IFRI, 26 March 2009, with Tatsuo Masuda, Andre Mernier et Richard H. Jones

    International Nuclear Information System (INIS)

    Schulke, Ch.

    2009-01-01

    The conference was related with some of the major questions concerning global energy governance today, the role of the different international organizations dealing with energy, the rules of the game between market and state players, the efforts to deal with climate change, and the integration of emerging countries in global energy governance, the roles of the different international organizations dealing with energy (will we see further fragmentation or more cooperation between them?). Tatsuo Masuda in his contribution discussed global energy governance from an oil perspective. Andre Mernier noted the particular nature of the Energy Charter, which, as it is founded upon an international treaty, is unlike other organizations in being legally binding. The legal basis of the organization means that agreements are especially powerful. Then Richard H. Jones underlined that last summer's volatility in oil markets, the ensuing financial and economic crisis, the major disruption in gas supplies to European markets this winter and the upcoming climate change negotiations have led to increasing calls for a stronger global dialogue on energy issues. This dialogue should deal with prices and investment, energy security and climate change

  6. The Construction of the Other and the Self in André Gide's Travels in the Congo and Frantz Fanon's Black Skin, White Masks

    Directory of Open Access Journals (Sweden)

    Raphaël Lambert

    2003-06-01

    Full Text Available Reportedly, André Gide's Travels in the Congo (1929 had fostered reforms of the colonial policy in French Africa. In Travels , Gide reports cases of economic exploitation, abuses of power, use of terror, torture, and even homicidal raids against recalcitrant villagers and, at least in one case, Gide takes it upon himself to have a man prosecuted. Yet his account, through the lense of post-colonial thinking, betrays reactionary and biased views of Africans. Gide does not object to the colonial system per se , but rather blames its malfunction on both a lack of infrastructures and administrative involvement. In Black Skin, White Masks (1952, Frantz Fanon denounces colonialism, focusing on its dehumanizing effects. If Fanon believes that it is the responsibility of those oppressed to regain their freedom, he is also aware that colonized people have internalized racial stereotypes to the point of self-loathing. Hence Black Skin can be read as a rebuttal to Travels . While Travels , published only twenty years earlier, clings to values of past centuries—supporting France's "civilizing" mission in Africa, Black Skin looks toward the future as it condemns the ideology of colonialism. Both liberals, communist sympathizers and social activists, Gide and Fanon represent the two opposite poles of the colonial issue.

  7. El Dioscórides de Andrés Laguna en los textos de Cervantes: de la materia medicinal al universo literario

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    Francisco López-Muñoz

    2007-12-01

    Full Text Available The literary works of Miguel de Cervantes have been widely studied from numerous points of view, including the medical one. In the present work, we defend the hypothesis that the Andrés Laguna version of Dioscorides was the source used by Cervantes in his literary passages related to therapeutic aspects, especially in relation to plants with medicinal properties. This book, a copy of which was in Cervantes’ private library, is the only medical treatise cited by the novelist in any of his writings (Don Quixote. Apart from the medicinal plants mentioned in his works, of which we have identified chicory, oleander, henbane, opium poppy, rosemary, rhubarb, tobacco, tamarisk, seeds of spurge, and vervain, Cervantes also seemed familiar with the effects of different pharmaceutical preparations produced from plants (white ointment, Aparicio’s Oil, narcotic powders, etc.. Our hypothesis is backed up by Cervantes’ use of descriptions similar to those of Laguna in his Dioscorides (the hallucinogenic effects of witches’ ointments in The Colloquy of the Dogs, the therapeutic properties of rosemary in the treatment of wounds and traumatisms in Don Quixote, the narcotic effects of opium in The Jealous Extremaduran, the psychodysleptic effects of some love potions in The Licentiate of Glass, or the toxic effects of some poisons in The Spanish-English Lady, and even, in some cases, by use of Laguna’s similar quotations (as in his reference to the purging of excessive bile in Don Quixote.

  8. Remediation Technology of Contaminated Areas with Organochlorines: A Preliminary Evaluation Seeking Potential Applications on the Site of Street Capua, Santo André - SP

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    Mauro Silva Ruiz

    2012-12-01

    Full Text Available This paper is aimed to analyze the use of remediation technologies for areas contaminated with organochlorine based on a literature review and discussions with specialists. The remediation technologies analyzed were bioremediation, phytoremediation, nanotechnology, chemical oxidation, and thermal desorption. The purpose is to identify and compare “key problems” for each of these technologies envisaging the use of one or more of these them f or the remediation of the Capua Street site in Santo André, SP. Four databases were used in the preliminary literature review: Scopus, SciELO, Web of Science, and Science Direct. A survey questionnaire was designed to gather information on publications of scientific papers and patents, specific uses of these technologies by companies, and cases of application. Since the quality of the data and information obtained from this questionnaire application was not satisfactory, a new research approach for complementing them was undertaken. For this purpose, the Web of Science was selected as the most adequate data basis to carry out this second survey. However, it was realized that even for this database - that is reference for evaluating academic institutions, researchers and maturity of technologies – bias coming from the original data source can affect the survey results. Moreover, as the number of keywords used in the research consisted of generic terms for each technology, it can also be assumed that if some authors have used very specific terms, a small amount of work published by them would possibly have been misrepresented in the final result.

  9. El fantasma de la puta-peluquera: Género, trabajo y estilistas trans en Cali y San Andrés Isla, Colombia

    Directory of Open Access Journals (Sweden)

    Jeanny Lucero Posso

    Full Text Available Resumen: A través de un uso crítico de la perspectiva de la interseccionalidad, la investigación etnográfica y exploratoria analiza las imbricaciones del género, la clase social, la etnicidad y la sexualidad en las trayectorias laborales de un conjunto de estilistas transfemeninas en Santiago de Cali y San Andrés Isla, Colombia. Las distancias sociales que se construyen entre diferentes actores (estilistas gais, estilistas de clase alta blancos heterosexuales, personas raizales heterosexuales y la clientela cisgénero producen de manera específica los sentidos otorgados al trabajo en las peluquerías y sus fronteras difusas con la prostitución. Si por un lado el efecto de clase y la dominación cisgenerista imposibilitan el ascenso social de las mujeres trans caleñas, el tabú heterosexista del sistema étnico prohíbe y niega las feminidades trans como parte de la identidad raizal.

  10. Professor André Jouve (1909-2001): A French cardiologist who was a pioneer of clinical vector-electrocardiography and cardiovascular epidemiology.

    Science.gov (United States)

    Puddu, Paolo Emilio

    2016-01-01

    André, Julien, Auguste Jouve was born in Marseilles on June 10, 1909 son of Xavier Marie Francois Louis Jouve MD and Marie Louise Charlotte Vigliengo his wife. He had a brilliant medical career in Marseilles: Resident at Marseilles Hospitals in 1931, major of his promotion, then an Assistant in 1943 and a Chief in 1951, to become Associate Professor of Medicine in 1946 and finally Full Professor of Clinical and Experimental Cardiology in 1954. Fellow of several Cardiological Societies, he became President of the French Society of Cardiology in 1968, Vice-President of the European Society of Cardiology in 1972 and finally President of the French College of Vascular Pathology in 1973. He had been a WHO Expert for degenerative and cardiovascular diseases from 1958 to 1981 and a National correspondent of the Academy of Medicine in 1977. He was decorated by the Légion d'Honneur (Officer in 1975). He retired in 1981 and died in 2001. Clinical vector-electrocardiology and cardiovascular epidemiology were the main areas of his interest where he made essential contributions such as the famous treatise on ECG. The Heart Cantini Center was considered his leading creation and action, where the first French heart transplantation was performed in 1968, the first French epidemiological investigation on coronary risk factors took place, the idea of starting prevention at pediatric age was clearly outlined and the need of concentrating on psychological and dysmetabolic factors was precisely advocated for indexing later development of ischemic heart diseases. These achievements are reviewed and put into perspective. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. BIOLOGICAL AND ENVIRONMENTAL PECULIARITIES OF INTRODUCTION OF WASHINGTONIA FILIFERA (LIND. EX ANDR. H. WENDL. EX BARY AT THE SOUTHERN COAST OF CRIMEA

    Directory of Open Access Journals (Sweden)

    Yuriy V. Plugatar

    2018-01-01

    Full Text Available Abstract. Aim of this research is to study winter resistance, drought resistance, resistance to fungal diseases and harmful insects of Washingtonia filifera (Lind. ex Andr., H. Wendl. ex A. Bary, 1879 and to examine the possibility of the subsequent selection using the experimental mutagenesis for increasing its frost resistance at the Southern Coast of the Crimea (SCC. Material and methods. The material and objects of our research were the collection plantations of Washingtonia filifera in the Arboretum of Nikitsky Botanical Garden (NBG and parks of the South Coast of Crimea. Research methods: comparative-ecological, biometric, analytical and visual. To achieve the objective, the following results were obtained in the course of the studies. The history of introduction of this species in the NBG has been described and its occurrence at the Southern Coast of the Crimea (SCC shown. An analysis of the quantitative biometric indicators of the leaves’ growth and die-back on average over the vegetation period on the basis of phenological observations over the test plants has been carried out taking into consideration the existing agricultural background. The reasons and factors influencing the frost resistance of this species depending on the combination of the set of meteorological indicators causing a certain level of frosting depending not only on the minimum negative temperatures but also on the soil and atmospheric moisture have been identified. Thresholds values of the impact of extreme negative temperatures for the Washingtonia filifera at the lethal and sub-lethal levels have been identified. Danger of infection of the representatives of the Arecaceae family (Arecaceae C.H. Schultz with the new types of dangerous phytophages has been identified. The possibility of its selection with the use of a mutagen – colchicine has been shown. Main conclusions. The criteria have been outlined which will give the opportunity in the future to provide

  12. Interview with Dr. Andre Davy, Honorary President, International Union of Phlebology; Honorary President, French Society of Phlebology; Honorary President, European Society of Phlebectomy. Interview by Jose Antonio Olivencia.

    Science.gov (United States)

    Davy, A

    2000-06-01

    Dr. Davy is the Honorary President International Union of Phlebology, Honorary President French Society of Phlebology, Honorary President European Society of Phlebectomy. Dr. Andre Davy was born in 1924 in Basse, Normandy. I met Dr. Davy in 1967 in a World Congress of Phlebology in Amsterdam. I was so impressed with his skills and knowledge that when he later on proposed to be associated in the practice of phlebology, I accepted immediately. That lead to a very long medical and surgical partnership. He was an expert in the Muller phlebectomy and was also interested in chronic venous insufficiency, chronic stasis ulcer and lymphedema. He promoted sclerotherapy as part of the overall treatment of venous disease. In the early seventies, he started a training program that included not only theoretical but also practical knowledge of phlebology. In 1974 he published a book entitled, "Les Varices." He organized the first Franco-British Symposium of Phlebology that was held in Touquet in May 1981. That symposium was a complete success. It was immediately followed by a second Franco-British symposium and later on by the creation of the Venous Forum of the Royal Society of Medicine, the birth of the English journal "Phlebology," the North American Society of Phlebology, and the American Venous Forum. Later, he became Editor in Chief of Phlebologie, the journal of the French Society of Phlebology. He was named President of the French Society of Phlebology in 1986 and in 1989 President of the International Union of Phlebology. This very well educated and calm gentleman with a very outward tranquil appearance and great strength of character has always held strong opinions. He is now retired at his family home in Pont L'Eveque, France and spends his time reading, listening to the music of his favorite composers Verdi and Mahler, continuously visiting old friends such as Jean Van der Stricht, Robert Muller, Claude Gillot, and still remaining very close to his family. PAUL OUVRY

  13. Physical, chemical, current profile, water pressure, sea surface temperature, meteorological, and other data from current meters, bottle casts, pressure gauges, meteorological sensors, current meters, and other instruments from the ANDRE NIZERY and other platforms from the TOGA Area - Atlantic as part of the Seasonal Response of the Equatorial Atlantic Experiment/Francais Ocean Et Climat Dans L'Atlantique Equatorial (SEQUAL/FOCAL) project from 1964-01-01 to 1985-12-31 (NODC Accession 8700150)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical, chemical, current profile, water pressure, sea surface temperature, meteorological, and other data were collected from the ANDRE NIZERY and other platforms...

  14. Descripción morfoagronómica de materiales de plátano (Musa AAB, ABB y banano (Musa AAA cultivados en San Andrés Isla Morpho-agronomic Description of Plantain (Musa AAB, ABB and Banana (Musa AAA Materials Grown in San Andres Island

    Directory of Open Access Journals (Sweden)

    Oscar Javier Parra Pachón

    2009-10-01

    Full Text Available Durante el primer semestre de 2005 se estudiaron los cultivares de plátano y banano en fincas y parcelas de 15 agricultores típicos participantes en programas conjuntos de la Secretaría de Agricultura y Pesca de San Andrés Isla y de la Universidad Nacional de Colombia sede Caribe. A partir de descriptores de INIBAP, IPGRI y CIRAD y revisiones bibliográficas.se describen morfológicamente los materiales de Musa cultivados en la Isla, así como las prácticas de los productores isleños, Se identificaron cuatro clones del subgrupo plátano (Musa AAB: un Hartón (‘Horse’ y tres Dominico-Hartón (‘Tallo Negro’, ‘Tallo Blanco’ y ‘Cincuenta’ del subgrupo ABB se hallaron un material de Bluggoe (‘Boscó’ y un Felipita. El subgrupo banano AAA presentó dos materiales Gros Michel (denominados Común y Chino y uno de banano (Rojo. El plátano tiene gran importancia para los agricultores de la Isla, siendo el Boscó el clon más aceptado entre consumidores por su adaptación a las condiciones edafológicas y climáticas. El banano es menos cultivado; ya que los suelos, el clima y las enfermedades como sigatoka negra, condicionaron el desarrollo de clones. El trabajo sugiere prácticas de fácil implementación que podrían aumentar la producción en los sistemas de huerto mixto tropical que predominan en la Isla.During the first semester, 2005 we studied the plantain and banana cultivars in small farms of 15 volunteer regular producers, who were participating in joint programs of the Agriculture and Fisheries Secretariat of San Andres Island and the Colombian National University Caribbean Headquarters. We described morphologically the Musa cultivars identified in the island, as well as agricultural practices of the island producers, using the INIBAP, IPGRI and CIRAD (1996 descriptors and bibliographical reviews. We identified four clones within the plantain sub-group Musa AAB: a Horn type and three French-Horn; and within the ABB

  15. Linguagem experimental: o discurso do consumo em Sexo, de André Sant'Anna, e o discurso da 'existencialidade' , em Lugar público, de José Agrippino de Paula

    OpenAIRE

    Romulo de Almeida Portella

    2006-01-01

    O objetivo principal desta dissertação é investigar as obras Sexo, de André SantAnna, e Lugar Público, de José Agrippino de Paula, a partir das noções que lidam com a vitalidade das formulações verbais, no que dizem respeito à elaboração da linguagem literária e a estruturação desta como conhecimento a ser apreendido. O trabalho contribui para um melhor entendimento da estética do experimentalismo, que é abordada em tais narrativas ficcionais. This dissertations main aim is to inves...

  16. Valoración del servicio ambiental hidrológico en el sector doméstico de San Andrés Tuxtla, Veracruz, México

    OpenAIRE

    Ana Lid del Ángel Pérez; Andrés Rebolledo Martínez; José Alfredo Villagómez Cortés; Rigoberto Zetina Lezama

    2009-01-01

    Entre las iniciativas de conservación en México, existe un programa de pago por servicios ambientales en áreas de gran importancia por sus valores ecológicos. Un caso es el de San Andrés Tuxtla, Veracruz, donde el pago no representa una opción económica sostenible a los dueños de predios, por lo que deberá incorporarse también el reconocimiento social. El objetivo del trabajo fue obtener el valor del bosque y paisajes alternativos en la población que recibe sus beneficios en forma de agua. Se...

  17. Epidemiología de la enfermedad de Chagas en el municipio Andrés Eloy Blanco, Lara, Venezuela: infestación triatomínica y seroprevalencia en humanos

    OpenAIRE

    Rodríguez-Bonfante,Claudina; Amaro,Aned; García,María; Mejías Wohlert,Ligia Elena; Guillen,Pamela; Antonio García,Rafael; Álvarez,Naysan; Díaz,Marialejandra; Cárdenas,Elsys; Castillo,Silvia; Bonfante-Garrido,Rafael; Bonfante-Cabarcas,Rafael

    2007-01-01

    Se realizó un despistaje serológico y recolección de vectores en cuatro comunidades rurales del municipio Andrés Eloy Blanco, Estado Lara, Venezuela. La muestra fue escogida en forma sistemática y aleatoria basada en conglomerados familiares. Se muestrearon 869 habitantes para determinar anticuerpos anti-Trypanosoma cruzi y anti-Leishmania sp. por inmunofluorescencia indirecta, aceptando como positivo diluciones > a 1:32 para anticuerpos anti-T. cruzi no reactivos para antígenos de Leishmania...

  18. Muusika : Hortus Musicus Moskvas. Eesti Rahvusmeeskoor Toulouse'is. Joaquín Rodrigo 100. Georg Ots kuuel plaadil. "Kiriku laulu- ja palveraamat" ئ 10. "Vikerraadio" heategevuskontsert. Artur Kapi ühingu esimees on Andres Uibo / Vello Mäeots

    Index Scriptorium Estoniae

    Mäeots, Vello, 1940-2015

    2001-01-01

    20. XI esines Hortus Musicus Moskvas Eesti saatkonnas. Eesti Rahvusmeeskoor kandis 15.XI Toulouse'is koos Toulouse'i Rahvusliku Linnaorkestriga ette Jean Sibeliuse "Kullervo". 22.XI tähistatakse hispaania helilooja Joaquín Rodrigo 100. sünniaastapäeva. Estonia teatri Valges saalis esitleti kogumik-CD-d "Georg Ots ئ Anthology". "Kiriku laulu- ja palveraamat" sai 30.XI 10. aastaseks. 3.XII toimub Tallinnas Kaarli kirikus "Vikerraadio" heategevuskontsert "Aita alustada elu". 26.X asutati Suure-Jaanis Rahvusvaheline Artur Kapi Ühing, mille esimeheks valiti organist Andres Uibo

  19. Andréa Slemian. Sob o Império das Leis. Constituição e unidade nacional na formação do Brasil (1822-1834

    Directory of Open Access Journals (Sweden)

    Oscar Javier Castro

    2010-07-01

    Full Text Available El constitucionalismo moderno y la formación de los Estados nacionales son procesos que comenzaron a tomar forma con las revoluciones, a ambos lados del Atlántico, a finales del siglo xviii y a comienzos del xix. El tópico examinado por Andréa Slemian hace parte de estos procesos. Analiza cómo se comenzaron a sentar las bases del constitucionalismo moderno liberal y la formación del Estado nacional en Brasil, que, a pesar de sus particularidades, estaba conectado con los procesos revolucionarios hispanoamericano, estadounidense y europeo.

  20. Influencia del polimorfismo del receptor de andrógenos en la masa ósea, masa muscular y condición física en niños y niñas

    OpenAIRE

    Rodríguez García, Lorena

    2015-01-01

    Programa de doctorado: Actividad Física, Salud y Rendimiento Deportivo Premio Extraordinario de Doctorado. Rama Ciencias Sociales y Jurídicas [ES]Para determinar el efecto de ciertos polimorfismos del gen del receptor de andrógenos sobre la masa muscular y la masa ósea, se estudió una muestra poblacional de 152 niños y 116 niñas sanos y físicamente activos (estudios I y II). La composición corporal se determinó mediante absorciometría fotónica dual de rayos X (DXA) y antropometría. La c...

  1. Juventude, intelectualidade e política: a ativação do "legado" de André Forster e a consagração de uma geração Youth, intellectuals and politics: the activation of André Foster's "legacy" and the acclamation of a generation

    Directory of Open Access Journals (Sweden)

    Eliana dos Reis

    2003-01-01

    Full Text Available Este artigo trata da temática referente às dinâmicas de construções geracionais e ao trabalho de memória, ativados por determinados agentes sobre um momento histórico específico. Para tanto, propõe-se, num primeiro momento, uma breve discussão bibliográfica sobre as noções de «geração» e «memória», principalmente sobre o potencial heurístico destas. No momento seguinte, o empreendimento recai na análise de um conjunto de narrativas e homenagens centradas na mobilização política da juventude de esquerda do MDB gaúcho na «luta contra a ditadura» (especialmente o exame de um Grande Expediente realizado na Assembléia Legislativa do RS em homenagem póstuma ao sociólogo e líder político André C. Forster. Com estes dois momentos pretende-se discutir o uso operacional de determinadas categorias para a compreensão dos movimentos históricos e dos personagens que os animam.This article deals with the themes related to the construction of generational dynamics and the memory work activated by certain agents on a specific historical moment. In order to do that, a brief bibliographical discussion is firstly proposed on the notions of "generation" and "memory", specially on their heuristic potential. Afterwards, an analysis is developed of a group of narratives and tributes centered on the leftist youth's mobilization within Rio Grande de Sul's MDB (Brazilian Democratic Movement in the "struggle against the dictatorship" (specially the examination of state parliament special session as a posthumous tribute to sociologist and political leader André C. Forster. Based on thos e two moments we intend to discuss the operational use of some categories to understand historical moments and the characters that animate them.

  2. Utopías y nacionalismo cultural en América Latina. La interpretación de Andrés Sabella a la contribución de Mariátegui, Vallejo y Eguren Utopias and Cultural Nationalism in Latin America. Andres Sabella's Interpretation of Mariategui's, Vallejo's, and Eguren's Contributions

    Directory of Open Access Journals (Sweden)

    José Antonio González Pizarro

    2012-06-01

    Full Text Available Se hace una relectura de los autores peruanos José Carlos Mariátegui, César Vallejo y José María Eguren, desde la visión del poeta y ensayista chileno Andrés Sabella, poniendo el énfasis en la noción de utopía -como lo no lugar, lo imposible- no solamente en el ámbito político-económico sino desde la construcción de un ''mundo'' donde la imaginación, la ensoñación, pueda edificar en la niñez, una visión contra la fealdad, lo monocromático, estableciendo con fuertes imágenes líricas el ''mundo imposible'' de lo que se estimaba lo ''perdido'' en la infancia. La interpretación de Sabella -al igual que los textos de los autores peruanos- se sitúa en un contexto de la construcción de un nacionalismo cultural en el continente, como correlato de la búsqueda de una identidad latinoamericana expresiva de la diferencia con los Estados Unidos.A re-reading of Peruvian authors José Carlos Mariátegui, César Vallejo, and José María Eguren is made from the view of the Chilean poet and essay writer Andres Sabella, putting emphasis on the notion of utopia -as the non-place, the impossible- not only in the political and economical ambit, but from the construction of a ''world'' where imagination and dreaming may build, during childhood, a view against ugliness and monocromaticity, establishing the ''impossible world'' of what was estimated as ''lost'' during childhood with strong lyric images. Sabella's interpretation -like Peruvian author's texts- lies within the context of a cultural nationalism construction, as a correlation to the search of a Latin American identity expressing the differences with the USA.

  3. Mucorales (Zygomycotina da Mata Atlântica da Reserva Biológica do Alto da Serra de Paranapiacaba, Santo André, SP Mucorales (Zygomycotina of the Atlantic Rainforest in the "Reserva Biológica do Alto da Serra de Paranapiacaba", Santo André, SP, Brazil

    Directory of Open Access Journals (Sweden)

    Iracema Helena Schoenlein-Crusius

    1997-07-01

    Full Text Available Treze táxons de Mucorales (Zygomycotina, distribuídos num total de 266 registros, foram isolados de folhas de Alchornea triplinervia (Spreng. Müll. Arg. colocadas em ambientes terrestre e aquático, e de amostras de solo e de água de riacho, coletadas mensalmente, de julho de 1988 a maio de 1990 na Reserva Biológica do Alto da Serra de Paranapiacaba, no município de Santo André, SP. As espécies que apresentaram os maiores números de registro de ocorrência foram Mucor hiemalis Wehmer (78 registros, Mucor circinelloides van Tieghem f. janssenii (Ledner Schipper (42 registros e Rhizopus arrhizus Fischer (30 registros. Cinqüenta por cento dos Mucorales encontrados na região são constituídos por espécies que estão sendo citadas pela primeira vez para a Mata Atlântica: Mucor hiemalis Wehmer f. silvaticus (Hagem Schipper, Rhizopus arrhizus Fischer, Rhizopus oligosporus Fischer, Rhizopus oryzae (Went. & Prinsen Geerlings, Zygorhynchus japonicus Vuill. e Zygorhynchns macrocarpus Ling-Young.Thirteen taxa of Mucorales (Zygomycotina, distributed in 266 occurrences were isolated from leaves of Alchornea triplinervia (Spreng. Müll. Arg. disposed in the terrestrial and aquatic environment, and of soil and stream water samples, monthly taken from July of 1988 to May of 1990, in the "Reserva Biológica do Alto da Serra de Paranapiacaba", in the municipality of Santo André, São Paulo State, Brazil. Mucor hiemalis Wehmer (78 records, Mucor circinelloides van Tieghem f. janssenii (Ledner Schipper (42 records and Rhizopus arrhizus Fischer (30 records were the most frequent species. Fifty percent of the Mucorales found are formed by species that are mentioned for the first time in the Atlantic Rainforest: Mucor hiemalis Wehmer f. silvaticus (Hagem Schipper, Rhizopus arrhizus Fischer, Rhizopus oligosporus Fischer, Rhizopus oryzae (Went. & Prinsen Geerlings, Zygorhynchus japonicus Vuill. and Zygorhynchus macrocarpus Ling-Young.

  4. Development and validation of analytical methodology for determination of polycyclic aromatic hydrocarbons (PAHS) in sediments. Assesment of Pedroso Park dam, Santo Andre, SP; Desenvolvimento e validacao de metodologia analitica para determinacao de hidrocarbonetos policiclicos aromaticos (HPAS) em sedimentos. Avaliacao da represa do Parque Pedroso, Santo Andre, SP

    Energy Technology Data Exchange (ETDEWEB)

    Brito, Carlos Fernando de

    2009-07-01

    The polycyclic aromatic hydrocarbons (PAHs), by being considered persistent contaminants, by their ubiquity in the environment and by the recognition of their genotoxicity, have stimulated research activities in order to determine and evaluate their sources, transport, processing, biological effects and accumulation in compartments of aquatic and terrestrial ecosystems. In this work, the matrix studied was sediment collected at Pedroso Park's dam at Santo Andre, SP. The analytical technique employed was liquid chromatography in reverse phase with a UV/Vis detector. Statistics treatment of the data was established during the process of developing the methodology for which there was reliable results. The steps involved were evaluated using the concept of Validation of Chemical Testing. The parameters selected for the analytical validation were selectivity, linearity, Working Range, Sensitivity, Accuracy, Precision, Limit of Detection, Limit of quantification and robustness. These parameters showed satisfactory results, allowing the application of the methodology, and is a simple method that allows the minimization of contamination and loss of compounds by over-handling. For the PAHs tested were no found positive results, above the limit of detection, in any of the samples collected in the first phase. But, at the second collection, were found small changes mainly acenaphthylene, fluorene and benzo[a]anthracene. Although the area is preserved, it is possible to realize little signs of contamination. (author)

  5. Fatores de risco para uso do tabaco em adolescentes de duas escolas do município de Santo André, São Paulo Risk factors for tobacco use in adolescent students of two high schools of Santo André city, São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Halley Ferraro Oliveira

    2010-06-01

    Full Text Available OBJETIVO: Avaliar fatores de risco para uso de tabaco em estudantes de duas escolas do ensino médio do município de Santo André (SP em 2005, bem como traçar o perfil do adolescente experimentador do fumo. MÉTODOS: Estudo transversal, com questionário padronizado, autoaplicável e anônimo aplicado a adolescentes escolares de ambos os sexos, matriculados no primeiro ano do ensino médio de duas escolas de Santo André, uma particular e outra pública. Foram levantadas as seguintes variáveis: idade, sexo, raça, prática de esportes, religião e hábitos do adolescente e da família. Definiu-se como "experimentador do fumo" o adolescente que experimentou cigarro (tabaco e não continuou o hábito tabagista. Foi feita a análise descritiva com o teste do qui-quadrado e os fatores de risco para "experimentar fumo" foram analisados por regressão logística. RESULTADOS: Dos 232 questionários aplicados, 226 (90% foram respondidos, sendo 137 (61% na escola particular e 89 (39% na estadual. Dentre os entrevistados, 54 (24% referiram já ter experimentado tabaco uma vez na vida (35 na escola privada e 19 na pública. Foram fatores de risco significativos para experimentar fumo na escola particular: mãe fumante (OR 12,4; IC95% 4,1-37,8 e amigos fumantes (OR 9,6; IC95% 3,1-29,9. Na escola pública, os fatores de risco para a mesma variável foram: consumo de bebida alcoólica (OR 8,8; IC95% 1,9-40,1, amigos fumantes, (OR 7,9; IC95% 1,9-31,3 e contato com fumaça do cigarro (OR 6,4; IC95% 1,6-26,2. CONCLUSÕES: Observou-se influência significativa do meio ambiente do adolescente, inclusive social e familiar, para a experimentação do tabaco.OBJECTIVE: To evaluate risk factors for tobacco use in high school students of two schools of the city of Santo Andre (São Paulo, Brazil in 2005, as well as to describe the profile of the adolescent who uses tobacco. METHODS: Cross sectional study that applied a standardized anonimous self

  6. Evaluation of underground water contamination of tubular wells, by fuels oil in Santo Andre City, Sao Paulo state: a contribution to the environmental management

    International Nuclear Information System (INIS)

    Mindrisz, Ana Copat

    2006-01-01

    The contamination of underground waters by hydrocarbons originated from gas stations has been object of increasing preoccupation in environmental organization all over the world. The organic compounds Benzene, Toluene, Ethylbenzene and Xylene (BTEX), present in these fuels, are extremely toxic to human health and could make impracticable the exploration of these contaminated waters by these kinds of pollutants and consequently the gasoline wells used for this purpose. In this work, it was carried out a diagnosis of the water quality with information and analyses, with the goals to snap shot the situation of the wells destined to domestic and commercial supply of water in the urban area of Santo Andre city, Sao Paulo state. There have been evaluated the presence of micron pollutants BTEX, after contamination due to leaks in fuel storage tanks close to the wells, in different places of the city. The physical chemistry parameters like color, turbidity and residual chlorine were also evaluated as well as trace elements, metals, anions like fluorine, sulphates, chlorine, nitrates and phosphates and bacteriological (total coliforms, thermo stable coliforms, heterotrophic bacteria). On definition of the sampling area, it was sought, at first, the evaluation of environmental contaminations historical series by gas stations, evaluating the set of information available at government environmental organizations and spatial representatively of the problem. For administration of the underground water quality it was adopted the methodology used by Companhia de Tecnologia de Saneamento Ambiental (CETESB), being accomplished a previous identification of contaminated potential areas and organizing a data base on landfills disposal and neglected places; registration of gas station services and, wells used by the population, industrial inventory with active and neglected maps taking into consideration the size and residues generation (such as SEMASA), prioritizing in this way the

  7. La Biblioteca Max von Buch de la Universidad de San Andrés y sus investigadores: Segunda parte de Un estudio de las necesidades de información, hábitos y características de Investigadores en Humanidades y Ciencias Sociales The Max von Buch library of the Universidad de San Andres and its researchers: Second part of A study of the information needs, habits and characteristics of Humanities and Social Science Researchers

    Directory of Open Access Journals (Sweden)

    Irene Münster

    2003-12-01

    Full Text Available Tal como fue mencionado en el artículo anterior el presente estudio fue elaborado con el propósito de entender e identificar las necesidades, el proceso de búsqueda de información, las características y los hábitos de los investigadores en Humanidades y Ciencias Sociales de la Universidad de San Andrés (UdeSA. En esta segunda parte del mismo se ha intentado identificar y evaluar su conducta en la Biblioteca Max von Buch de la Universidad a través del uso de los servicios que ésta les ofrece. Se ponen a consideración los resultados de una encuesta realizada, de la que se adjunta la segunda parte del formulario, con el fin de detectar sus necesidades de información.As mentioned in the previous article, the present study was conducted to understand and identify the characteristics, needs and habits of research from the Humanities and Social Sciences researchers at the Universidad de San Andres (UdeSA. This second part tries to identify and evaluate their performance at the Max von Buch library of the University through the services that it provides them. The results of the survey are presented, together with the second part of the questionnaire, with the aim of identifying information needs.

  8. Two members of the CERN HPD team present their babies. André Braem (left) holds in his hands a 5-inch glass HPD, while a ceramic HPD for medical applications is shown by Christian Joram. The large detector in the middle is a 10-inch HPD developed for an astrophysics experiment.

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    Two members of the CERN HPD team present their babies. André Braem (left) holds in his hands a 5-inch glass HPD, while a ceramic HPD for medical applications is shown by Christian Joram. The large detector in the middle is a 10-inch HPD developed for an astrophysics experiment.

  9. Surmahiirte tants; Pühapäeva hommik; Unistus venna külaskäigust; Kolm päeva voodipuhkust; Veepiir; Ei sugutunnuseid ega muid iseärasusi : [Luuletused] / Wallace Stevens ; inglise k. tlk. ja järelsõna: Andres Ehin

    Index Scriptorium Estoniae

    Stevens, Wallace

    1996-01-01

    Autorist lk. 212. Luuletuste 'Unistus venna külaskäigust', 'Kolm päeva voodipuhkust', 'Veepiir' ja 'Ei sugutunnuseid ega muid iseärasusi', mis on samuti ekslikult sealsamas W. Stevensile omistatud, autor on tegelikult Carlos Stewal. Vt. Ehin, Andres. Veavabandus // Looming. 1995. Nr. 5. Lk. 718

  10. O Ateísmo Francês Contemporâneo: uma comparação crítica entre Michel Onfray e André Compte-Sponville (Contemporary French Atheism: a Critical Comparison between Michel Onfray and André Comte-Sponville - DOI: 10.5752/P.2175-5841.2010v8n18p127

    Directory of Open Access Journals (Sweden)

    Agnaldo Cuoco Portugal

    2011-04-01

    Full Text Available Michel Onfray e André Comte-Sponville são os dois mais famosos representantes do ateísmo filosófico francês contemporâneo, que continua uma tradição iniciada no século XVIII de negação irreligiosa da noção monoteísta de Deus. Embora compartilhando várias ideias, como o naturalismo e, obviamente, a rejeição do monoteísmo, suas propostas têm diferenças importantes. Onfray imputa à religião a maioria dos males enfrentados pela humanidade, recusando-se a fazer qualquer concessão à tradição religiosa monoteísta, e propondo uma filosofia libertária de tipo hedonista e materialista. Comte-Sponville vê aspectos positivos na religião no tocante à manutenção da unidade social e propõe uma espiritualidade mística ateia. O artigo faz uma breve apresentação de suas teses e formula críticas a ambas as propostas. Onfray está muito mais preocupado em convencer de uma proposta política do que em argumentar filosoficamente em favor de uma tese e Comte-Sponville não parece perceber as consequências auto-refutadoras do naturalismo, que também torna muito problemática a própria noção de moralidade. Palavras-chave: Michel Onfray; Comte-Sponville; ateísmo; neoateísmo; naturalismo.  Abstract Michel Onfray and André Comte-Sponville are the most famous representatives of philosophical contemporary French atheism, which is a continuation of a tradition begun in the 18th Century of irreligious denying of the monotheistic notion of God. Although sharing many ideas, like naturalism and, obviously, the rejection of the monotheistic conception of God, their proposals show important distinctions. Onfray blames on religion most of evils faced by humanity, refusing to make any concession to monotheism, and proposing a libertarian, hedonistic, materialistic philosophy. Comte-Sponville sees positive aspects in religion regarding the keeping of social unity, and puts forward an atheistic spirituality. The article makes a brief

  11. Mõistulood ungari moodi / Andres Allpere

    Index Scriptorium Estoniae

    Allpere, Andres

    2000-01-01

    Ungari mängufilmidest : "Mulle andis Vanajumal Pestis laterna kätte" ("Nekem lámpást adott kezembe az Úr Pesten"), režisöör Miklós Jancsó; "Nägija Simon" ("Simon mágus"), režisöör Ildikó Enyedi; "Süüdistus" ("A vád"), režisöör Sándor Sára ja "6 : 3", režisöör Péter Tímár

  12. Avastades muinasjuttude muinasjutte / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2005-01-01

    Mängufilm Peeter Paani kuju loojast kirjanik James M. Barrie'st "Avastades Eikunagimaad" ("Finding Neverland") : režissöör Marc Forster : peaosas Johnny Depp : Ameerika Ühendriigid - Suurbritannia 2004

  13. DVD-d / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Kolm mängufilmide DVD-d : ameerika mängufilm "Kahe tule vahel" ("Departed"; režissöör Martin Scorsese; 2006), inglise mängufilm "Hea aasta" ("A Good Year"; režissöör Ridley Scott; 2006) ja eesti kokandusfilm "10 erinevat liharooga", kus toiduvalmistamist juhivad Madis Milling ja Tiina Kimmel (2007)

  14. Filmikunsti kolm palet / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    1999-01-01

    Tallinna filmifestival linastunud mängufilmid "Reekviem" : režissöör Alain Tanner : Šveits - Prantsusmaa - Portugal 1998, "Õnnelikult koos" : režissöör Wong Kar-Wai : Hongkong 1997 ja "Tuntud vana laul" : režissöör Alain Resnais : Prantsusmaa - Šveits - Suurbritannia 1997

  15. Kaljujooniste keskus Arizonas / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    1998-01-01

    Arhitekt William Bruderi projekteeritud kaljujooniste uurimis- ja eksponeerimiskeskus Phoenixis, Arizonas säilitab kivijooniseid, mille autoriteks olid sealset piirkonda kuni 16. sajandini asustanud hohokamid

  16. Saaremaa politseijuht pensionile / Andres Sepp

    Index Scriptorium Estoniae

    Sepp, Andres, 1976-

    2005-01-01

    Kuressaare politseijaoskonna ülemkomissar Ants Ley esitas politseiametile lahkumisavalduse. Väidetavalt on nimetatud ühe võimaliku politseijuhikandidaadina Lääne prefektuuri teenistusosakonna komissari Aare Alliku nime. Lisa: Ants Ley

  17. Ruum, ca 1986 / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2006-01-01

    Alates 1990. aastate algusest kuulub ruum postmodernse kultuuriteooria käibesõnavarasse, räägitakse ka "ruumilisest pöördest" kultuuriteoorias. Erinevatest ruumiloogikatest, modernse kultuuri ja ruumi klassilisest ja soolisest problemaatikast. Henry Lefebvre'i, Frederic Jamesoni, Edward Soja, Rosalyn Deutsche, Griselda Pollock'i ruumianalüüsist

  18. DVD-d / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Kolm mängufilmide DVD-d : ameerika sõltumatu mängufilm "Karm tüdruk" ("Hard Candy"; režissöör David Slade; 2005), ameerika mängufilm "Kaitseingel" ("The Guardian"; režissöör Andrew Davis; 2006) ja Venemaa õudusfilm "Surnud tütred" ("Mjortvõje dotsheri"; režissöör Pavel Ruminov)

  19. Vabadus teeb rikkaks / Andres Arrak

    Index Scriptorium Estoniae

    Arrak, Andres, 1958-2017

    2005-01-01

    Autor analüüsib Eesti majandusvabadust kahe edetabelipõhjal: ühte koostab alates 1996. aastast Kanadas asuv Frazeri Instituut, teist USA-s asuv Heritage Foundation ja majandusajakiri The Wall Street Journal. Diagramm: Majandusvabaduse indeksi muutus mullu Euroopa Liidus

  20. Crimson kirjutab ajalugu / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2002-01-01

    Crimsoni (Hollandi kunstiajaloolaste firma) raamatust "Mart Stami püksid. Lugusid Hollandi moraalse modernismi kulisside tagant", selle põhjal Piet Mondriani maali "Victory Boogie Woogie" jõudmisest 1998. a. Haagi linnamuuseumi, arhitekt Jacobus Johannes Oudi (1890-1963) imago kujundamisest ja tema loomingu rekonstrueerimisest

  1. Torunis kohtuvad naaberteatrid / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    1999-01-01

    22. mail algas Poola väikelinnas Torunis rahvusvaheline teatrifestival "Kontakt". Eestist valis festivali juhtkond välja Priit Pedajase lavastuse "Mao tee kalju peal", mida mängitakse 27. mail ja 28. mail ka Varssavis

  2. Turuliider riskikapitali abiga / Andres Aarma

    Index Scriptorium Estoniae

    Aarma, Andres

    2006-01-01

    Läti mobiilsidevahendite ja -teenuste müüja DT Mobile saavutas turuliidri staatuse riskikapitali abiga. Lisa: Läti telekomiturg aastal 2005. Diagramm. Kommenteerivad DT Mobile'i juhatuse esimees Uldis Prieditis ja BaltCapi partner Dagnis Dreimanis

  3. Elagu noor kino! / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    2007-01-01

    Käesoleva TMK numbriga kaasas olevast DVDst "Valik eesti tudengifilme", mis tutvustab tudengite lühifilme (ilmus Kinobussi eestvõttel) : T. Toom "Tuul", B. Demidova "Roosa kleit ja nahksed püksid", K. Sarv "2pic", R. Merivoo "Mis värvi on armastus", R. Mandri "Annaliisa", E. Vasli "Nagu ikka", M. Oja "Rain Terrain" ("Varjude maa"), J. Matjus "Suvine dokumentaal", L. Kuusk, R. Võsa, M. Monko, H. Melesk "Eestimaa. Revisited", Johnson ja Johnson (I. Köster ja T. Talve) "Mõrv striptiisi ajal"

  4. Kirjad Viljale Bakuus / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2008-01-01

    Kirjavahetus Bakuus elava ja töötava Vilja Peetsi ning Tallinnas elava Vidadi Mamedoviga Aserbaidžaani kultuuriloo, poliitika, ajaloo ja ühiskonnaelu teemadel. Puudutatakse ka Montesquieu Pärsia kirju, Voltaire'i Filosoofilisi jutustusi ja Ahhundovi Kämalüddövlä kirju

  5. Teema endiselt õhus / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    Saksa poliitiline põnevusfilm "Balti torm" ("Baltic Storm"), mis kujutab parvlaev "Estonia" hukku : stsenarist, produtsent Jutta Rabe : režissöör Reuben Leder. Filmi Tallinna esilinastusel viibinud ajalehe Washington Times Balti korrespondendi Drew Wilsoni ja filmi stsenaristi ja kaasprodutsendi Kaj Holmbergi ütlusi teema kohta

  6. Vanglarahvas tantsib Euroopasse / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2005-01-01

    Rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre : stsenaristid Rene Vilbre, Teet Kask, Helena Jonsdottir : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir : osatäitjad Mait Malmsten, Ruslan Stepanov. Filmi võtted toimusid Tartu vanglas

  7. Avignoni totaalne teatrifestival / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Avignoni teatrifestivalil nähtust. Lähemalt Marc Wolters'i ühemeheteater "Colt Warmers", Chapelle Sainte Claire (Alfred Jarry) "Kuningas Ubu", Herman Hesse "Sidharta" mängituna India teatritrupi poolt, "Movin' Melvin Brown : Me, Ray Charles and Sammy D. Jr" ning Virgine Mirabeau koreograafial tantsuetendus "Shoult I Stay Or..." Art's Fusion esituses

  8. Sein on ees / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    2009-01-01

    Laurent Cantet ja Françoise Begaudeau filmist "Seinte vahel", mis on pooldokumentaalne lugu probleemsest klassikollektiivist Prantsusmaa ühes riigikoolis. Filmi aluseks on kooliõpetaja Françoise Begaudeau romaan

  9. Demokraatia tulevik kaalul / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2004-01-01

    Ilmunud ka: Infoleht, nr. 44, veebr., 2004, lk. 5, lüh. Autori arvates on mitmed sammud, mida valitsev koalitsioon Res Publica juhtimisel astub, suunatud demokraatia kitsendamisele, võrdsete võimaluste piiramisele ning valijatega manipuleerimise suurendamisele. Kommenteerib põhiseaduskomisjoni esimees Urmas Reinsalu

  10. DVD-d / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Lühitutvustused DVD-del ilmunud filmide kohta - "Jan Uuspõld läheb Tartusse" (A. Maimik, R. Tolk, Eesti 2007), "Öö muuseumis" ("Night at the Museum"; Shawn Levy, USA 2006), "78. paragrahv. 2." (Mihhail Hleborodov, Venemaa)

  11. Puitarhitektuuri preemiad - 2009 / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2009-01-01

    Konkursist "Eesti Parim Puitehitis 2009" ja premeeritud töödest. Peapreemia pälvis suvila (EasyHome'i moodulmaja) Jõelähtmel, arhitekt Sten Ader (SKAD Arhitektid). Eripreemiate saajad, äramärgitud töö

  12. Kan kostholdsdata fra hjerte- karundersøkelsene i Finnmark, Sogn og Fjordane og Oppland brukes i analyser av andre sykdommer enn hjerte-karsykdom?

    Directory of Open Access Journals (Sweden)

    Elin Bjørge Løken

    2009-10-01

    Full Text Available  SAMMENDRAGEt selvadministrert spørreskjema om utvalgte sider av det vanlige kostholdet er besvart av ca. 60 000 mennog kvinner i de tre første hjerte-karundersøkelsene i Finnmark, Sogn og Fjordane og Oppland (1974-1988.Sammenligning av kostdata hos et utvalg av deltakerne som både besvarte spørreskjemaet og et 24 timerskostintervju, har vist at spørreskjemaet ikke bare ga et brukbart bilde av forbruket av melk, brød,smør/margarin og kaffe, men også for beregnet inntak av energi, protein, fett og kalsium. Skjemaetinneholdt få spørsmål om friske plantematvarer og kan derfor ikke gi data for inntak av antioksidanter.Resultatene viste klare forskjeller i kostholdet mellom menn og kvinner og i forhold til bosted. Videreanalyser har vist statistisk signifikante sammenhenger mellom en eller flere kostkomponenter og risiko forulike typer kreft og lårhalsbrudd. Materialet omfatter en forholdsvis ung kohorte, og kan på sikt væreinteressant for studier av andre sykdommer eller dødsårsaker som antas å ha sammenheng med en ellerflere av de kostkomponentene som spørreskjemaet omfatter. Ved vurdering av resultatene er det viktig å tahensyn til at spørreskjemaet ikke omfattet det totale kostholdet.Løken EB, Solvoll K. Can dietary data from the cardiovascular disease studies in Finnmark,Sogn og Fjordane and Oppland be used to analyse risk for other diseases?Nor J Epidemiol ENGLISH SUMMARYA self-administered questionnaire covering selected aspects of the habitual diet was answered byapproximately 60 000 men and women who participated in the three first screenings of cardiovasculardisease risk factors in the counties of Finnmark, Sogn og Fjordane and Oppland (1974-1988. A subsampleof the subjects was in addition interviewed about their intake of foods and beverages on the day before thequestionnaire was handed out. It appeared that the questionnaire not only provided reasonable data onconsumption of milk, bread, butter/margarine and

  13. Andres Lipstok : 2008. aasta kustutab Eestist odava allhanke ettevõtted / Andres Lipstok ; interv. Andres Reimer

    Index Scriptorium Estoniae

    Lipstok, Andres, 1957-

    2008-01-01

    Ilmunud ka: Vesti Dnja 21. jaan. lk. 5. Eesti Panga presidendi sõnul jõuab praeguse prognoosi kohaselt majandus kasvukiiruse madalseisu esimesel poolaastal, mõni ettevõte, mis kasutab näiteks odavat tööjõudu, võib minna pankrotti. Prognoosi põhjal ei tohiks Eesti majandus tänavu nulli langeda. Selgitus, miks Eesti peaks ikkagi eurole üle minema ja seda võimalikult kiiresti

  14. Labor de Andrés Manuel del Río en México: profesor en el Real Seminario de Minería e innovador tecnológico en minas y ferrerías

    Directory of Open Access Journals (Sweden)

    Uribe Salas, José Alfredo

    2006-12-01

    Full Text Available This article analyzes the scientific and technological training of Andrés del Río in Europe and, his professional activities in New Spain at the end of the eighteenth and the beginning of the nine teenth century. I study his scientific practice at Mexico City’s Royal Mining Seminary as a form of culture; therefore, this research examines the «scientific practice» and goals of Andrés del Río from a historicist and cultural perspective. Del Río contributed to forge a scientific culture that became part of the collective imaginary in his new country of residence. However his direction in the draining of the Morán mines in the mining district of Real del Monte and the establishment of the ferrería (pre-industrial iron smelter of Guadalupe in the Coalcomán highlands, in the former Michoacán Bishopric, allowed him to show his abilities as a technician and his skill in the design, projection and execution of two engineering projects (one hydraulic, the other industrial—the first of their genre in the New World.

    El trabajo analiza la formación científica y tecnológica de Andrés del Río en Europa, y su desempeño profesional en Nueva España a fines del siglo XVIII y principios del XIX. Se estudia su práctica científica en el Real Seminario de Minería de la ciudad de México como una forma de cultura, y por lo tanto se examina la «práctica científica» de Andrés del Río y sus objetivos desde una perspectiva historicista y cultural. Del Río contribuyó a forjar una cultura científica como parte del imaginario colectivo del nuevo país de residencia. Pero serían los encargos de desaguar las minas de Morán en el distrito minero de Real del Monte y el establecimiento de una ferrería en la sierra de Coalcomán, en el antiguo Obispado de Michoacán, las que dejaron ver sus dotes de tecnólogo y la pericia en el diseño, proyección y ejecución de dos obras de ingeniería, una hidráulica y la otra industrial, las

  15. Obras tempranas de vivienda por André Wogenscky (1956-1970: la relación entre el cuerpo, la atmósfera interior y la envolvente

    Directory of Open Access Journals (Sweden)

    Ignasio Requena-Ruiz

    2014-12-01

    Full Text Available Durante veinte años André Wogenscky fue uno de los más fieles colaboradores de Le Corbusier. El presente artículo discute cómo sus primeros trabajos (1956-70 suponen una evolución de las lecciones del maestro a través de una comprensión sensorial de la relación entre cuerpo humano, arquitectura y clima. En particular, se aborda su acercamiento a las cuestiones ambientales y la percepción humana en sus proyectos de vivienda. Este trabajo está basado en una investigación original en los archivos Wogenscky del Centre d’archives d’architecture du XXe siècle en el Institute français d’architecture.

  16. Saint-André-des-Eaux (Côtes-d’Armor : étude archéologique d’une église paroissiale et de ses peintures murales

    Directory of Open Access Journals (Sweden)

    Mathias Dupuis

    2008-07-01

    Full Text Available Le petit village de Saint-André-des-Eaux se situe dans les Côtes-d’Armor, à une dizaine de kilomètres au sud-est de Dinan. Les vestiges de l’ancienne église paroissiale et de son cimetière prennent place quelques centaines de mètres à l’écart du bourg (fig. 1, sur les abords boisés de l’étang de Bétineuc, un vaste plan d’eau artificiel créé dans les années 1970 afin d’assainir cette zone autrefois marécageuse. En effet, le contexte de plaine, la proximité de la Rance et le maillage resserré ...

  17. Saint-André-des-Eaux (Côtes-d’Armor : nouveaux éléments sur l’église et sur ses décors peints

    Directory of Open Access Journals (Sweden)

    Mathias Dupuis

    2009-09-01

    Full Text Available Nous avions déjà présenté dans le précédent numéro du Bulletin du Centre d'études médiévales d’Auxerre les premières recherches sur l’ancienne église paroissiale de Saint-André-des-Eaux . La réalisation de sondages en juin 2008 ainsi qu’une dernière série d’observations sur le bâti, préalables à la consolidation des murs de l’église et des vestiges de peintures murales, permettent désormais de mieux cerner l’histoire monumentale de cet édifice et de ses décors peints.Quatre sondages ont été o...

  18. Reconfiguración de alianzas políticas en contextos críticos: los caciques de San Andrés de Machaca (Pacajes, Audiencia de Charcas, siglos XV-XVII

    Directory of Open Access Journals (Sweden)

    Ariel Jorge Morrone

    2015-02-01

    Full Text Available Este trabajo explora las estrategias de reconfiguración política articuladas por los líderes étnicos de San Andrés de Machaca (actual provincia Ingavi, departamento de La Paz, Bolivia, en tres contextos críticos: la invasión incaica (a mediados del siglo xv, la sistematización del orden colonial hispánico (fines del siglo xvi y el desarrollo posterior de este sistema (primera mitad del siglo xvii. Cada situación definió nuevas reglas del juego político, ante las cuales las autoridades étnicas apelaron a una variedad de prácticas: la reorganización territorial, la asignación de recursos (de consumo y de prestigio, los rituales de negociación, la memoria genealógica y el tramado de redes personales.

  19. Efeitos do γ-orizanol e extrato hidroalcólico de Thuya occidentalis sobre linhagens de câncer de próstata responsivas e não-responsivas a andrógenos

    OpenAIRE

    Gabriela Elisa Hirsch

    2015-01-01

    O câncer de próstata é a segunda causa de morte entre homens no Brasil. É tipo um câncer de crescimento lento, podendo levar anos para o tumor atingir 1 cm3, porém, em alguns casos ele pode se espalhar pelo corpo, sendo o osso o principal sítio de metástase. No estágio de desenvolvimento do câncer conhecido como metástase, o principal tratamento consiste em terapia de restrição andrógena, levando as células prostáticas a pararem de proliferar, uma vez que elas crescem em resposta a presença d...

  20. Prevenção de anemia no primeiro ano de vida em centros de saúde do município de Santo André, São Paulo

    DEFF Research Database (Denmark)

    Szarfarc, S C; Berg, Gabriele; Santos, A L

    1996-01-01

    The aim of this study was to evaluate the efficacy of an iron prophylactic supplementation program, in three health centers of Santo André, in São Paulo state. The prevalence of anemia was identified in a control group consisting of 201 children of 1 year old. The intervention group consisted...... and anemia and its risk to children's health. When the children were 12 months old, the diagnosis of anemia was made through dosage of hemoglobin concentration and the results were compared with those of the control group. It was verified that the 2 groups presented similar prevalences. It is important...... to realize that children with low frequency of visits to the health centers had prevalence of anemia significantly higher than those with high frequency. Some factors that possibly contributed to the result of the intervention are discussed....

  1. Narcotráfico, violencia y crisis social en el Caribe insular colombiano: El caso de la isla de San Andrés en el contexto del Gran Caribe

    Directory of Open Access Journals (Sweden)

    Silvia Mantilla

    2011-01-01

    Full Text Available El presente artículo tiene por objetivo presentar un diagnóstico preliminar de la magnitud del tráfico de drogas, sus dinámicas, modalidades, y las condiciones sociales y económicas que favorecen el desarrollo de este negocio ilegal en la isla de San Andrés (Colombia. El análisis se desarrolla, no obstante, en el marco de la condición histórica y natural de “zona de tránsito” de drogas, armas y otros recursos ilegales, que se le atribuye a la región del Gran Caribe, entendida como un continuo geográfico, histórico y cultural en el que se observan patrones comunes en materia de amenazas a la seguridad, la geopolítica de las relaciones con Estados Unidos y los efectos sociales y económicos derivados del flagelo del narcotráfico. En este sentido, el caso de la isla de San Andrés (Colombia se examina más como parte de la dinámica insular gran caribeña que como parte de las tendencias propias del negocio en la Colombia continental, lo que permite, sin embargo, establecer las conexiones entre ambos espacios regionales - el insular y el continental - y, a la vez, evaluar el impacto regional del fenómeno a partir de las conexiones ilegales que desde el archipiélago se establecen con algunos países vecinos del Gran Caribe. Finalmente, se sostiene la hipótesis de que el fenómeno del narcotráfico se instala en la isla como resultado de factores geohistóricos, culturales y socioeconómicos que en conjunto han determinado la participación activa de distintos sectores de la sociedad en este negocio ilegal.

  2. A Natureza e a gênese das Minas do Sul nos livros de André João Antonil e Sebastião da Rocha Pita

    Directory of Open Access Journals (Sweden)

    Francisco Eduardo de Andrade

    2006-06-01

    Full Text Available Este artigo trata do sentido cosmológico da Natureza, em voga na época das representações do barroco (séculos XVII e XVIII, quando aplicado ao contexto novo da América portuguesa com o descobrimento das Minas de ouro. Dois autores da Bahia foram significativos das primeiras visões de Natureza e da sociedade das Minas do ouro: André João Antonil e Sebastião da Rocha Pita. Ambos produziram obras sobre a gênese do espaço minerador, buscando, de algum modo, integrá-lo a uma história providencial da colonização portuguesa. Para isso, investiram em temas e imagens que, além de condicionados por evidentes interesses políticos e econômicos dos plantadores do litoral, refletem os vínculos discursivos dos coloniais eruditos.This work deals with the cosmological sense of the Nature, which has been intensively studied at the time of baroc representations (17th and 18th centuries, applied to the Portuguese America new context of gold mines discoveries. Two authors from Bahia were very important to the early views on the Nature and on the society in gold mines: André João Antonil and Sebastião da Rocha Pita. Both have made studies about the genesis of the mining space in such a way to integrate it in an opportune history of the Portuguese colonization. To do this, they dealed mainly with subjects and images which reveal discourse links of colonial wise persons, and also which were influenced by political and economical interests of the coastal farmers.

  3. Project watching the sky: a playful and constructivist approach in the practice of night sky observations for 2nd grade elementary school students in the city of Santo André

    Science.gov (United States)

    Voelzke, M. R.; Faria, R. Z.; Pedroso, M.; Jacinto, C.; Silva, L. C. P.

    2017-07-01

    The Johannes Kepler planetary, located at the SABINA Parque do Conhecimento in the City of Santo André, Brazil, has equipments that allow the teaching and diffusion of Astronomy. The attendances take place during the week for schools and at weekends for the public. The attending focus is on elementary students from Santo André’s municipal schools, kids between 6 and 10 years old. The pedagogical team created attendance models with specific matters for each age. The model is only incorporated into the planetary agenda after the municipal teacheŕs approval. This paper reports the establishment and approval of an attending project for 2nd grade students between September and November 2014. The workshops "My first spyglass" and "Creating my constellations" and the planetary session "Watching the Sky" were created. The Municipal Education Office received the project and passed it to the schools. From the 51 municipal schools, 13 took part sending 21 classes, totaling 521 students. The project included activities for the students, such as the construction of spyglasses out of cardboard which made them learn about constellations of yeaŕs seasons and enabled them to create their own constellations. During the schools permanency in the planetary, the teachers received a survey to evaluate the pilot project. The evaluation of the researched items allowed to classify them into satisfactory, partially satisfactory or unsatisfactory. The results were 95% satisfactory, considering the following aspects: used script, applied workshops, participation, concern and content uptake by the students; and a satisfactory rate of 100% about the used resources. Upon the approval, the pedagogical team included definitively this attendance into their agenda.

  4. Proyecto de un servicio funcional a prestar en una biblioteca universitaria: "El Servicio de Información Departamental" de la Biblioteca Max von Buch (Universidad de San Andrés

    Directory of Open Access Journals (Sweden)

    Moira Guppy

    2001-06-01

    Full Text Available Este trabajo -elaborado para el Seminario "La organización de los Servicios al Público en la Biblioteca" (UBA, 1998- describe el proyecto de un servicio a desarrollar en la Biblioteca Max von Buch de la Universidad de San Andrés. El "Servicio de Información Departamental" ofrecerá a los docentes e investigadores acceso a los recursos disponibles dentro de su área temática (Internet, bases de datos, índices de artículos de publicaciones periódicas, revistas en texto completo, series estadísticas, etc. Estará elaborado en dos formatos: un cd-rom actualizado periódicamente, y una página Web en línea especialmente diseñada. Con la implementación de este servicio se logrará un gran ahorro de tiempo en la búsqueda, análisis, tratamiento y difusión de la información destinada a la investigación académica.This paper -presented at the seminary "Public Services Organization at the Library"- describes a project to be developed at the Max von Buch Library, Universidad de San Andrés. The "Academic Information Service" would be design to provide access to researchers and faculty to all the resources available whithin each discipline and research area in the Internet, databases, periodical indexes, full text periodicals, statistical data, etc. They will gain access to it from a cd-rom which would be updated periodically, and a web page specially designed. The implementation of this project would provide faculty with qualified information along with considerable time saving in their researches.

  5. Contabilidad y cobros de rentas en la Santa Capilla de San Andrés de Jaén. Dos siglos y medio tras la búsqueda de la eficiencia (1650-1900). (Accounting and income collection at the Santa Capilla de San Andrés in Jaén. Two and a half centuries in search of efficiency (1650-1900).

    OpenAIRE

    Lillo Criado, Juan Luis; Álvarez López, José Mª Carlos

    2006-01-01

    La Santa Capilla de San Andrés de Jaén es una institución benéfica que tiene sus orígenes en 1515 y aún pervive. Su contabilidad, establecida para la rendición de cuentas por parte del receptor, se sustentó en el método de cargo y data y en diversos libros necesarios, tales como los de hacienda, de gastos de meses o el cuaderno de no cobrados. En este trabajo, sobre la base del análisis de la enorme cantidad de datos que suministran sus cuentas entre 1650 y 1900, hemos estudiado la función de...

  6. Conocimiento sobre el fenómeno de las drogas en entre estudiantes y docentes de la Facultad de Medicina Universidad Mayor de San Andrés, La Paz, Bolivia Conhecimento sobre o fenômeno das drogas entre estudantes e docentes da Faculdade de Medicina da Universidade Mayor de San Andrés, La Paz, Bolívia Knowledge on drugs phenomenon by students and faculty from the Medical School at Universidad Mayor de San Andrés, La Paz, Bolivia

    Directory of Open Access Journals (Sweden)

    Maria del Pilar Navia-Bueno

    2011-06-01

    Full Text Available El objetivo de este estudio fue identificar el grado de conocimiento de los estudiantes y docentes de salud sobre drogas lícitas e ilícitas, relacionadas a: tipo, clasificación, acción, mecanismos, daños, consecuencias y efectos adversos además del uso y consumo. El diseño metodológico fue de "corte transversal, con una muestra de 172 estudiantes, profesores y residentes de las áreas de medicina y enfermería de la Universidad Mayor de San Andrés (UMSA, en Bolivia. Los resultados revelan que existe una debilidad en cuanto al conocimiento en relación a la clasificación de sustancias psicotrópicas de acuerdo con la estructura, propiedad química y efectos que producen en la salud, destacándose una diferencia significativa del conocimiento sobre drogas lícitas, como el alcohol y tabaco, con las drogas ilícitas. Se resalta el desconocimiento en todo el grupo estudiado sobre drogas lícitas e ilícitas, consecuencias y efectos adversos, lo que confirma la necesidad de mejorar la enseñanza en este contenido en las escuelas de salud.O objetivo deste estudo foi identificar o grau de conhecimento dos estudantes e professores da área da saúde sobre drogas lícitas e ilícitas, em relação ao tipo, classificação, mecanismos de ação, danos, consequências e efeitos adversos, decorrentes de seu consumo. Trata-se de estudo de coorte transversal, com amostra de 172 estudantes, professores e residentes das áreas de medicina e enfermagem da Universidad Mayor de San Andrés (UMSA, Bolívia. Os resultados revelam baixo nível de conhecimento dos sujeitos da investigação, relacionado à classificação de substâncias psicotrópicas, quanto à estrutura, propriedade química e efeitos que produzem na saúde, destacando-se diferença significativa entre o conhecimento sobre drogas lícitas, como álcool e tabaco, e drogas ilícitas. Ressalta-se o desconhecimento de todos os sujeitos da investigação sobre drogas lícitas e il

  7. Evaluation of underground water contamination of tubular wells, by fuels oil in Santo Andre City, Sao Paulo state: a contribution to the environmental management; Avaliacao da contaminacao da agua subterranea de pocos tubulares, por combustiveis fosseis, no municipio de Santo Andre, Sao Paulo: uma contribuicao a gestao ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Mindrisz, Ana Copat

    2006-07-01

    The contamination of underground waters by hydrocarbons originated from gas stations has been object of increasing preoccupation in environmental organization all over the world. The organic compounds Benzene, Toluene, Ethylbenzene and Xylene (BTEX), present in these fuels, are extremely toxic to human health and could make impracticable the exploration of these contaminated waters by these kinds of pollutants and consequently the gasoline wells used for this purpose. In this work, it was carried out a diagnosis of the water quality with information and analyses, with the goals to snap shot the situation of the wells destined to domestic and commercial supply of water in the urban area of Santo Andre city, Sao Paulo state. There have been evaluated the presence of micron pollutants BTEX, after contamination due to leaks in fuel storage tanks close to the wells, in different places of the city. The physical chemistry parameters like color, turbidity and residual chlorine were also evaluated as well as trace elements, metals, anions like fluorine, sulphates, chlorine, nitrates and phosphates and bacteriological (total coliforms, thermo stable coliforms, heterotrophic bacteria). On definition of the sampling area, it was sought, at first, the evaluation of environmental contaminations historical series by gas stations, evaluating the set of information available at government environmental organizations and spatial representatively of the problem. For administration of the underground water quality it was adopted the methodology used by Companhia de Tecnologia de Saneamento Ambiental (CETESB), being accomplished a previous identification of contaminated potential areas and organizing a data base on landfills disposal and neglected places; registration of gas station services and, wells used by the population, industrial inventory with active and neglected maps taking into consideration the size and residues generation (such as SEMASA), prioritizing in this way the

  8. Relação entre situação social e crescimento físico, numa população infantil de Santo André, SP, Brasil Relationship between social situation and physical growth in children from Santo Andre, State of S. Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Maria Stella Ferreira Levy

    1977-09-01

    Full Text Available Baseado em dados sócio-antropológicos e em medidas antropométricas coletados no Município de Santo André, Estado de São Paulo, Brasil, foi analisada a população infantil de ambos os sexos e de treze idades diferentes (0, 3, 6 e 9 meses, 1 ano, 1 ano e meio, 2 a 8 anos. Foram utilizadas 3 variáveis independentes ISSE - índice de situação sócio-econômica da família (baseado nas inter-relações da média de gasto familiar mensal "per capita" e a instrução e ocupação do chefe da casa; CATANCES - construída a partir da informação sobre a nacionalidade dos ascendentes das crianças até 3ª geração; e Tamanho do Grupo Residencial. Como variáveis dependentes, utilizou-se a estatura, o peso e o Índice de Kaup. Considerando a relação positiva entre melhores condições de vida e desenvolvimento físico, constatou-se (através do teste de ordenação de médias de Duncan que, embora as médias das medidas diferissem segundo as variáveis independentes, isso não acontecia igualmente nas mesmas idades e nos dois sexos. Observou-se pelos resultados das análises de variância, na maioria das vezes significantes, que as variáveis selecionadas explicavam muito pouco da variação das medidas nas várias idades e sexos. Conclui-se que a amostra estudada, segundo as variáveis independentes deste estudo, difere entre idades em ambos os sexos. Isto levanta uma série de questões sobre quais as variáveis mais adequadas a estudos desse gênero. Sugere-se, consideradas as duas categorias de variável CATANCES, a utilização de duas "tabela padrão" para peso e altura, segundo regiões brasileiras. Quanto ao índice de Kaup, evidenciou-se a necessidade de ser encontrada uma função matemática específica para cada idade, uma vez que, ao menos em relação a crianças em crescimento, o índice não media aquilo a que se propunha.This article was based on some of the data collected in the county of Santo André, State of Sew Paulo

  9. Fatores Associados à Obesidade e ao Padrão Andróide de Distribuição da Gordura Corporal em Mulheres Climatéricas Factors Related to Obesity and Android Pattern of Body Fat Distribution in Climacteric Women

    Directory of Open Access Journals (Sweden)

    Diana Beatriz Filip Raskin

    2000-08-01

    Full Text Available Objetivos: descrever as características de um grupo de mulheres climatéricas, conhecer a freqüência e os fatores associados à obesidade e ao padrão andróide de distribuição da gordura corporal. Métodos: estudo observacional com 518 pacientes com idade entre 45 e 65 anos em um ambulatório de climatério. Foram considerados a idade, cor, status menopausal, tempo de menopausa, atividade física, tabagismo, dieta, etilismo, antecedentes pessoais e familiares de hipertensão, diabetes, doença cardiovascular, dislipidemia e obesidade. O índice de massa corpórea e a relação das medidas cintura/quadril foram variáveis dependentes. Na análise estatística utilizaram-se os testes de Wilcoxon, c² de Pearson, com nível de significância de 5%, e análise múltipla por regressão logística. Resultados: mais de dois terços das participantes eram não-obesas com perfil andróide e menopausadas. Aproximadamente um quarto tinha atividade física adequada, era tabagista, metade referiu dieta inadequada e um quinto era etilista. Pacientes com perfil andróide apresentaram média etária maior que mulheres com padrão ginecóide. Antecedentes pessoais de obesidade, hipertensão, diabetes e história familiar de diabetes relacionaram-se com obesidade e padrão andróide. O status pós-menopausa associou-se significativamente ao perfil andróide. Conclusões: a maioria das mulheres foram não-obesas com perfil andróide, brancas, pós-menopáusicas, sedentárias, não-tabagistas nem etilistas. Os principais fatores associados à obesidade e padrão andróide foram os antecedentes pessoais de obesidade, hipertensão arterial, diabetes, história familiar de diabetes e, particularmente, o status pós-menopausa com o perfil andróide.Purpose: to describe sociodemographic characteristics of a group of climacteric women in order to discover the frequency and the variables associated with obesity and android profile of body fat distribution. Methods

  10. Mercado de Bens Simbólicos do Futebol: A Estratégia Empreendedora da Gestão Andrés Sanchez no Sport Club Corinthians Paulista

    Directory of Open Access Journals (Sweden)

    Renato Berton

    2013-06-01

    Full Text Available O crescimento do mercado de bens simbólicos se tornou realidade em todos os continentes. Particularmente, o futebol, desde a Copa do Mundo de 1990, passou por crescimento financeiro incomum. A exploração da paixão dos torcedores/consumidores pelo futebol e por seus respectivos clubes transformou-se em grande atividade comercial e de prestação de serviços, após o advento da Lei Pelé em março de 1998. Consequentemente, os clubes deixaram de ser meras agremiações esportivas e se tornaram grandes organizações, responsáveis por oferecer um produto atraente e cada vez mais rentável. A estratégia empreendedora da gestão de Andrés Sanchez possibilitou ao Sport Club Corinthians Paulista, em 2012, alcançar o primeiro lugar de empresa no futebol brasileiro e a sexta colocação no cenário mundial. Por meio de pesquisa exploratória de natureza qualitativa, ex-post factum, acompanhada de entrevista em profundidade com gestores participantes do empreendimento e membros da torcida organizada, o objetivo central da pesquisa, na perspectiva fenomenológica, buscou identificar as estratégias empregadas na Gestão Andrés Sanchez para a valorização da marca. Os resultados da pesquisa apontam para a integração das estratégias funcionais com a estratégia dos negócios. Na percepção dos entrevistados, a visão empreendedora permitiu ao clube, em quatro anos (2008-2011, formar a base de seu acelerado crescimento para, posteriormente, alcançar posicionamento diferenciado e, consequentemente, vantagem competitiva sustentável.DOI: 10.5585/podium.v2i1.35

  11. Disputas marítimas en el Caribe colombiano: la pesca de tortugas en el archipiélago de San Andrés y Providencia, 1910-1930

    Directory of Open Access Journals (Sweden)

    Sharika Crawford

    2017-10-01

    Full Text Available There has been a long history of turtle hunting in the Greater Caribbean, especially in Colombian waters around the archipelago of San Andrés and Providence. This article is focused on Colombia’s efforts to affirm its national borders and to strengthen its control over its territorial waters, and on how the new regulations that these measures entail affect turtle hunters in the Caribbean Sea. Using travel stories, newspapers from Jamaica, Colombia and the United States, as well as diplomatic correspondence, interviews and secondary sources, this study analyzes the national and regional implications of these problems. This makes it possible to conclude that the islanders, in the company of Colombian officials, attempted to defend their insular territory and its maritime borders against both real and imaginary threats. Their efforts were aimed at restricting the extraction of marine resources within the country’s territorial waters, as part of the government’s interest in reinforcing the integrity of the Colombian nation-state in the Caribbean.

  12. Parâmetros de qualidade físico-químicos e avaliação da atividade antioxidante de folhas de Plectranthus barbatus Andr. (Lamiaceae submetidas a diferentes processos de secagem

    Directory of Open Access Journals (Sweden)

    C.F.G SILVA

    2016-03-01

    Full Text Available RESUMO O presente trabalho descreve a composição físico-química, a avaliação da atividade antioxidante pelo método de sequestro de radicais livres DPPH, determinação de flavonoides e de fenóis totais dos extratos etanol, acetona e aquoso de Plectranthus barbatus Andr. (Lamiaceae, desidratadas em secador solar e em estufa de circulação de ar a 60 oC. Os valores de atividade de água encontrados para as duas secagens foram inferiores ao mínimo necessário para o crescimento e produção de toxina de patógenos de importância alimentar. Os resultados das análises físico-químicas demonstraram que ambos os processos mostraram-se eficientes na desidratação de P. barbatus. Os resultados demonstraram que os extratos acetona (estufa e etanol (estufa e secador solar foram os que apresentaram maior conteúdo de fenóis totais. O extrato etanólico (estufa apresentou maior quantidade de flavonoides e melhor potencial antioxidante (IC50 = 75,71 ± 10,57 µg mL-1.

  13. Manuel Grijalvo, Un Obispo Burgales en Filipinas. By Roberto Blanco Andrés. Burgos: Publicaciones de la Excma. Diputación de Burgos, 2011. 88 pages, plates.

    Directory of Open Access Journals (Sweden)

    Grace Liza Y. Concepcion

    2012-12-01

    Full Text Available This brief biography is one among many published works by RobertoBlanco Andrés, a Spanish historian who specializes in the history of religious orders in the Philippines, particularly the Augustinians. The aim of the present work is simple. It is to recount Fray Manuel Grijalvo’s life as a religious priest who occupied key positions in the Augustinian Order and in the Philippine church as bishop of Nueva Caceres (now Naga in the first half of the 19th century, at a time when both the Order and the church in the Philippines were undergoing transition. This succinct narration of an Augustinian bishop’s lifeopens a window through which one can appreciate Philippine history in the 19th century. Although brief, the summary of Grijalvo’s years in the Philippines, spent in Manila and Nueva Caceres, gives a relatively complete view of the challenges that the Catholic Church was facing in this era, both within the Augustinian Order and in the Diocese of Nueva Caceres. This is so because Grijalvo was an Augustinian missionary who also occupied key posts as parish priest in Batangas towns (1814 -1818 and in Pasig (1833 -1839 and 1831-1847. He was also procurator and prior of the Order between 1818 and 1832. In1848, he was appointed bishop of Nueva Caceres, a post he occupied until his death in 1861. His life, therefore, encapsulates the struggles and challenges of the Philippine Catholic Church and the Spanish colonial government.

  14. 'Sidun' e 'Creuza de mâ' di Fabrizio De André (1940–1999. La svolta etnica del cantautore genovese attraverso l’analisi di due canzoni esemplari

    Directory of Open Access Journals (Sweden)

    Vanna Lovato

    2014-01-01

    Full Text Available L’album Creuza de mâ (1984 di Fabrizio De André, composto e registrato grazie alla fondamentale collaborazione del musicista Mauro Pagani, rappresenta un unicum nella storia della canzone italiana, ed è più in generale un buon esempio di canzone d’autore moderna rielaborata secondo parametri musicali e linguistici diversi dagli standard della canzone di consumo tipici dell’epoca in cui l’album venne pubblicato, anticipando di quasi un decennio in Italia la moda della cosiddetta world music. Pur confermandosi ad oggi uno dei migliori esempi di ‘contaminazione’ tra canzone popolare –– rappresentata qui dall’uso del dialetto genovese –– e tradizione musicale mediterranea , nel 1984 il disco fu accolto in modo tiepido dal pubblico , ma ottenne  subito il plauso della critica e di molti colleghi ed estimatori, italiani e non; ricordiamo, tra gli altri, gli apprezzamenti fatti nel corso degli anni dal musicista inglese David Byrne.

  15. An improved $\\pi$K atom lifetime measurement

    CERN Document Server

    Yazkov, V

    2016-01-01

    This note describes details of analysis of data samples collected by DIRAC experiment on a Pt target in 2007 and Ni targets in 2008–2010 in order to estimate the lifetime of πK atoms. Experimental results consist of eight distinct data samples: both charge combinations ( π + K − and K + π − atoms) obtained in different experimental conditions corresponding to each year of data taking. Estimations of systematic errors are presented. Taking into account both statistical and systematic uncertainties, the lifetime of πK atoms is estimated by the maximum likelihood method. The above sample comprises the total statistics, available for the analysis, thus the improvement over the previous estimation [1,3] of the πK atom lifetime is achieved.

  16. Tõendid praktikasse / Ere Uibu, Ester Öpik

    Index Scriptorium Estoniae

    Uibu, Ere

    2016-01-01

    Eesti Õdede Liidu konverentsil tunnustati meditsiiniõdesid Sirje Kõvermäge, Kadri Piiri, Evelyn Evertit, Ere Uibut, Jane Freimani, Reet Tohvret, Teija Toivarit, Jane Remmerit, Ülle Tammsaart, Lily Parmu ja Kätlin Lünekundu

  17. First observation of $\\pi^{-}K^+$ and $\\pi^{+}K^-$ atoms, their lifetime measurement and $\\pi K$ scattering lengths evaluation

    CERN Document Server

    Afanasyev, Leonid

    2016-01-01

    The Low Energy QCD allows to calculate the ππ and π K scattering lengths with high precision. There are accurate relations between these scattering lengths and π + π − , π − K + , π + K − atoms lifetimes. The experiment on the first observation of π − K + and π + K − atoms is described. The atoms were generated in Nickel and Platinum targets hit by the PS CERN proton beam with momentum of 24 GeV/ c . Moving in the target, part of atoms break up producing characteristic π K pairs (atomic pairs) with small relative momentum Q in their c.m.s. In the experiment, we detected n A = 349 ± 62 (5.6 standard deviations) π − K + and π + K − atomic pairs. The main part of π K pairs are produced in free state. The majority of such particles are generated directly or from short-lived sources as ρ , ω and similar resonances. The electromagnetic interactions in the final state create Coulomb pairs with a known sharp dependence on Q . This effect allows to evaluate the number of these Coulomb pai...

  18. Innovació docent: gestió i desenvolupament d’activitats extracurriculars en l’àrea de la conservació-restauració de pintura mural. Capella de San Andrés (Sevilla-Espanya

    Directory of Open Access Journals (Sweden)

    Beatriz Prado-Campos

    2017-03-01

    Full Text Available INTRODUCCIÓ. Aquest article descriu una experiència pràctica d’innovació docent duta a terme en el grau universitari de Conservació i Restauració de Béns Culturals de la Universitat de Sevilla. MÈTODE. Les pràctiques acadèmiques descrites tenien com a objectiu fonamental contribuir activament a la formació dels alumnes i aportar-los una experiència pràctica professional real en traslladar-los del seu àmbit habitual, l’aula, a un entorn professional. RESULTATS. L’aplicació de la metodologia específica de conservació-restauració en projectes d’intervenció de pintura mural, concretament a la cúpula de l’església de San Andrés (Sevilla, va permetre que l’alumnat prengués contacte amb una realitat professional concreta, on el gran format de les pintures murals i l’aplicació de les mesures de seguretat laboral van tenir com a resultat la millora les seves destreses i habilitats pel que fa als processos propis de la seva professió. A més, va suposar una experiència d’interès per a la seva inserció laboral. DISCUSSIÓ. Es demostra, amb això, que utilitzant els recursos didàctics apropiats en el procés d’ensenyament i aprenentatge es pot ampliar la qualitat de la docència.

  19. Descripción morfoagronómica de materiales de plátano (Musa AAB, ABB y banano (Musa AAA cultivados en San Andrés Isla

    Directory of Open Access Journals (Sweden)

    Oscar Javier Parra Pachón

    2009-10-01

    Full Text Available Durante el primer semestre de 2005 se estudiaron los cultivares de plátano y banano en fincas y parcelas de 15 agricultores típicos participantes en programas conjuntos de la Secretaría de Agricultura y Pesca de San Andrés Isla y de la Universidad Nacional de Colombia sede Caribe. A partir de descriptores de INIBAP, IPGRI y CIRAD y revisiones bibliográficas.se describen morfológicamente los materiales de Musa cultivados en la Isla, así como las prácticas de los productores isleños, Se identificaron cuatro clones del subgrupo plátano (Musa AAB: un Hartón (‘Horse’ y tres Dominico-Hartón (‘Tallo Negro’, ‘Tallo Blanco’ y ‘Cincuenta’ del subgrupo ABB se hallaron un material de Bluggoe (‘Boscó’ y un Felipita. El subgrupo banano AAA presentó dos materiales Gros Michel (denominados Común y Chino y uno de banano (Rojo. El plátano tiene gran importancia para los agricultores de la Isla, siendo el Boscó el clon más aceptado entre consumidores por su adaptación a las condiciones edafológicas y climáticas. El banano es menos cultivado; ya que los suelos, el clima y las enfermedades como sigatoka negra, condicionaron el desarrollo de clones. El trabajo sugiere prácticas de fácil implementación que podrían aumentar la producción en los sistemas de huerto mixto tropical que predominan en la Isla.

  20. Descripción morfoagronómica de materiales de plátano (Musa AAB, ABB y banano (Musa AAA cultivados en San Andrés Isla

    Directory of Open Access Journals (Sweden)

    Parra Pachón Oscar Javier

    2009-12-01

    Full Text Available Durante el primer semestre de 2005 se estudiaron los cultivares de plátano y banano en fincas y parcelas de 15 agricultores típicos participantes en programas conjuntos de la Secretaría de Agricultura y Pesca de San Andrés Isla y de la Universidad Nacional de Colombia sede Caribe. A partir de descriptores de INIBAP, IPGRI y CIRAD y revisiones bibliográficas.se describen morfológicamente los materiales de Musa cultivados en la Isla, así como las prácticas de los productores isleños, Se identificaron cuatro clones del subgrupo plátano (Musa AAB: un Hartón (‘Horse’ y tres Dominico-Hartón (‘Tallo Negro’, ‘Tallo Blanco’ y ‘Cincuenta’ del subgrupo ABB se hallaron un material de Bluggoe (‘Boscó’ y un Felipita. El subgrupo banano AAA presentó dos materiales Gros Michel (denominados Común y Chino y uno de banano (Rojo. El plátano tiene gran importancia para los agricultores de la Isla, siendo el Boscó el clon más aceptado entre consumidores por su adaptación a las condiciones edafológicas y climáticas. El banano es menos cultivado; ya que los suelos, el clima y las enfermedades como sigatoka negra, condicionaron el desarrollo de clones. El trabajo sugiere prácticas de fácil implementación que podrían aumentar la producción en los sistemas de huerto mixto tropical que predominan en la Isla.

  1. Contabilidad y cobros de rentas en la Santa Capilla de San Andrés de Jaén. Dos siglos y medio tras la búsqueda de la eficiencia (1650-1900

    Directory of Open Access Journals (Sweden)

    Juan Luis Lillo Criado

    2006-07-01

    Full Text Available La Santa Capilla de San Andrés de Jaén es una institución benéfica que tiene sus orígenes en 1515 y aún pervive. Su contabilidad, establecida para la rendición de cuentas por parte del receptor, se sustentó en el método de cargo y data y en diversos libros necesarios, tales como los de hacienda, de gastos de meses o el cuaderno de no cobrados. En este trabajo, sobre la base del análisis de la enorme cantidad de datos que suministran sus cuentas entre 1650 y 1900, hemos estudiado la función de cobro de rentas del receptor y la eficiencia en el desempeño de la misma, así como la legitimación conseguida por los principales promotores de cambios en orden a su mejora. Para ello hemos incidido especialmente en los sistemas de remuneración al receptor y, en particular, en el cambio producido desde un escenario de empleo a sueldo fijo a otro de comisionista con retribución variable. Después de investigar los impagados con un sistema y otro y de relacionarlos con la evolución de las propiedades y de sus rentas, se concluye que el cambio benefició a los receptores pero no a la institución, por lo que no mejoró la eficiencia buscada.

  2. Miguel Covarrubias e Andrés Guevara: a influência do cubismo na ilustração editorial do início do século XX

    Directory of Open Access Journals (Sweden)

    Daniel Bueno

    2014-06-01

    Full Text Available Este artigo dedica-se à análise das contribuições do Cubismo para a ilustração editorial do começo do século XX. Para tanto, optou por um momento específico representado pelo começo de carreira do ilustrador e caricaturista mexicano Miguel Covarrubias no mercado editorial americano no início dos anos 1920, e pelo início da obra do ilustrador e caricaturista paraguaio Andrés Guevara no Brasil na mesma época. O texto pretende abordar a questão das influências e conexões entre as vanguardas artísticas modernas do começo do século passado e a arte comercial - feita sob encomenda para veículos do mercado editorial - da caricatura e ilustração: qual a amplitude dessa troca de informações gráficas; quais são as contribuições para o contexto da ilustração; e quais são as diferenças entre a produção das vanguardas e os trabalhos de ilustração influenciados por elas. Busca, também, refletir sobre as peculiaridades do desenho para o mercado editorial, pautado – muitas vezes - pelo caráter híbrido de interesses do artista e do cliente.

  3. Novas curvas de crescimento da Organização Mundial da Saúde: comparação com valores de crescimento de crianças pré-escolares das cidades de Taubaté e Santo André, São Paulo New World Health Organization growth standards: comparison with growth data of preschool children of the cities of Taubaté and Santo André, São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Claudio Leone

    2009-03-01

    Full Text Available OBJETIVO: Em 2007, a Organização Mundial da Saúde (OMS propôs um referencial de crescimento de cinco a 19 anos, a ser utilizado em continuidade ao referencial de menores de cinco anos (de 2006, que, entre outras características, aos cinco anos de idade mostra um bom ajuste com a curva de 2006. Este estudo visa comparar os referenciais da OMS com o crescimento observado em pré-escolares brasileiros. MÉTODOS: A partir dos dados antropométricos de 2.830 crianças com idade entre três e seis anos de duas amostras das cidades de Taubaté e Santo André, em São Paulo, foram calculados os valores dos percentis (P 5, 50 e 95 de peso, estatura e índice de massa corpórea (IMC. Os valores dos novos referenciais da OMS foram comparados a esses resultados de acordo com o sexo e a faixa etária. RESULTADOS: Nos percentis de estatura, o referencial apresentou valores próximos ou pouco superiores aos dos pré-escolares até os cinco anos. Nessa idade, a tendência se inverte, obtendo-se valores progressivamente inferiores até os sete anos. Para peso e IMC, em todas as idades consideradas, o P5 e 50 dos referenciais são pouco menores que os das crianças, mas o P95 indica uma tendência de crescimento progressivamente menor, fazendo com que, próximo aos sete anos, o P95 de IMC dos pré-escolares da amostra seja cerca de 4kg/m² maior. CONCLUSÕES: Os referenciais da OMS apontam uma prevalência menor de magreza (desnutrição e baixa estatura entre cinco e sete anos e, ao mesmo tempo, uma elevação importante da prevalência de obesidade entre três e sete anos de idade.OBJECTIVE: The World Health Organization (WHO, in 2007, proposed a growth reference standard from five to 19 years to be used in continuation to the 2006 one (for children younger than five years-old. This growth chart shows a satisfactory adjustment at five years with the 2006 curve. This study aims to compare WHO references with the growth observed in Brazilian preschool

  4. Tappev kuulsus viib Chicago lavale / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    Muusikafilm "Chicago", mille aluseks John Kanderi - Fred Ebb'i muusikal : režissöör Rob Marshall : Ameerika Ühendriigid 2002. 1975.a. selle muusikali Broadwayl lavale toonud Bob Fosse mõjust filmi stiilile

  5. Vene suurim teatrifestival tuleb! / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2005-01-01

    Vene draamafestivali "Kuldne mask" paremik 11.-16. oktoobrini Tallinnas. Tutvustatakse lavastusi - "Vennad ja õed" (lav. L. Dodin), "September. doc" (lav. M. Ugarov), "Oblom off" (M. Ugarov), "Kuningas Oidipus" (lav. A. Prikotenko)

  6. Noor Eesti muusika plahvatab! / Andres Lõo

    Index Scriptorium Estoniae

    Lõo, Andres

    2004-01-01

    Popmuusikaüritustest muusikafestivali Hea Uus Heli raames: "1öö%" Von Krahlis ja "Viva la HUH!" kultuuritehases Polymer 8. ja 9. okt.. Jaapanlase Emi Maeda kontserdist Kanuti Gildi saalis 8. okt.ja elektroonilise muusika esitajatest Von Krahlis

  7. Finhvalen fra Blokhus og andre eksotiske fund

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen; Jensen, Lasse Fast; Olsen, Morten Tange

    2016-01-01

    I uge 8 strandede en død finhval (Balaenoptera physalus) ved Blokhus Strand. Finhvalen, der som bardehval lever af både fisk, blæksprutter og forskellige krebsdyr, er det næststørste pattedyr på kloden, kun overgået af den nært beslægtede blåhval (Balaenoptera musculus). Det stod hurtigt klart...

  8. Kolakowski : kaks vaatepunkti, kaks dialektikat / Andre Trinity

    Index Scriptorium Estoniae

    Trinity, André, pseud., 1974-

    2004-01-01

    Rets. rmt.: Kolakowski, Leszek. Horror metaphysicus. Tallinn, 2000 ; Kolakowski, Leszek. Religioon : Kui Jumalat ei ole olemas...Jumalast, kuradist, patust ja nn religioonifilosoofia teistest muredest. Tallinn, 2004

  9. Kolm õde Eestist Londoni laval / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    1999-01-01

    Inglise näitleja Steven Dykesi näidend "Kolonistid" Londoni Bridge Lane Theatre laval. Näidend on inspireeritud A. Tshehhovi "Kolmest õest" ja tegevus toimub Eestis, tegelased on siinsed venelased

  10. Noor Stirlitz seikleb Tallinnas / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2009-01-01

    Vene telekanalil Rossija alanud uuest seriaalist "Issajev" (režissöör Sergei Ursuljak, nimiosas Daniil Strahhov), mille esimeste osade tegevus toimub Tallinnas 1920-ndate aastate alguses. Võrdlus Grigori Kromanovi sama aega ja tegelasi hõlmava filmiga "Briljandid proletariaadi diktatuurile" (Tallinnfilm 1975)

  11. Dominique Perrault' realistlik teater / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    1999-01-01

    Prantsuse arhitekti Dominique Perrault' näitus Eesti Arhitektuurimuuseumis Rotermanni soolalaos. Hoonetest: Hotel Industriel Berlier (1985-1990) ja Rahvusraamatukogu Pariisis, Berliini 2000. a. olümpiamängude velodroom ja ujula, Tehnikaraamatute keskus Marne-la Valleés (1992-1998).

  12. City Car = The City Car / Andres Sevtshuk

    Index Scriptorium Estoniae

    Sevtshuk, Andres, 1981-

    2008-01-01

    Massachusettsi Tehnoloogiainstituudi (MIT) meedialaboratooriumi juures tegutseva Targa Linna Grupi (Smart City Group) ja General Motorsi koostööna sündinud kaheistmelisest linnasõbralikust elektriautost City Car. Nimetatud töögrupi liikmed (juht William J. Mitchell, töögruppi kuulus A. Sevtshuk Eestist)

  13. Viljandi paugutab kolme esietendusega / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Janusz Glowacki "Fortinbras jõi end täis" Viljandi Kultuuriakadeemia teatrikunsti eriala 6. lennu esituses, lavastaja Kalju Komissarov ja Sven Heiberg ; Ott Aardami "Börs ja börsitar" ja Henrik Ibseni "Nora/Maja", lavastaja Helen Rekkor

  14. Uus film tegi Raagist tegija / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2005-01-01

    Eesti Televisiooni fiktiivne dokumentaaldraama "August 1991" : stsenarist ja režissöör Ilmar Raag : produtsent Gerda Kordemets : operaator Janno-Hans Arro. Lisatud augustiputshi ajal teletorni kaitsnud Jüri Joosti ja Peeter Milli kommentaar

  15. Eesti animafilmi trump peitub minevikus / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2000-01-01

    Animafilmifestivalil Hollywoodis "The World Animation Celebration" sai Pärna joonisfilm "Porgandite öö" esimese preemia 15-30-minutiliste filmide kategoorias. Film on valitud koos Janno Põldma joonisfilmiga "Armastuse võimalikkusest" ja Priit Tenderi filmiga "Viola" augustis Hiroshimas toimvale festivalile. Eesti animafilmi absurdihuumor, mis pärineb nõukogude perioodist, on selle edu üks nurgakive.

  16. "Tõuse hommikul vara : ..." : [luuletused] / Leili Andre

    Index Scriptorium Estoniae

    Andre, Leili, 1922-2007

    2000-01-01

    Sisu: "Tõuse hommikul vara: ..." ; Vikerkaar ; Sünd ; "Kasvada ..." ; "Sind manitsevad ..." ; "Tahad olla vaba? Ole vaba! ..." ; "Kes selle tamme istutas? ..." ; "Õnn mu lävest mööda sõidab. ..."

  17. Igavus teatris on igavaim igavus / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2004-01-01

    Läti teatri esindusfestivalist Riias. Lähemalt järgmistest lavastustest : R. Baumanise "Indranid" M. Gruzdovi lavastuses, J. Rainise "Puhu, tuul" G. Polishtshuki lavastuses, E. Siendze "Vasakpööre" O. Kordersi lavastuses ja E. Albee "Kes kardab Vurginia Woolfi?" R. Vaivarsi lavastuses

  18. Euroopa Nõukogu on uinuv kaunitar / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2009-01-01

    Euroopa Nõukogu on küll organisatsioon, mis põhineb väärtustel, kuid samas on need väärtused juba mõnda aega odavmüügis. EN ei kutsu väiksemaid riike ebademokraatia pärast korrale, sest Venemaal on olukord veel hullem. Inimõiguste kohus kui ENi tõhusaim töövahend

  19. El regreso del andrógino

    Directory of Open Access Journals (Sweden)

    Juan Manuel Rodríguez

    2014-12-01

    Full Text Available Refiriéndose al chip, señala que hoy este es tan indispensable como el oxígeno, este minicomponente tiene ventajas múltiples: portátil, memoria extraordinaria, liviano, con múltiples opciones de diversión y placer, sin consumo de energía y fácil de remplazarlo. El mundo moderno exige estar enchufados. La memoria humana ya no reside en la razón histórica, sino en la del circuito integrado, la conciencia tiende a desaparecer y se ha remplazado por el chip. La capacidad de recibir información esta limitada por la incapacidad humana de captarla y entenderla, quizá por eso seamos bastante pobres en varios de los procesos de manejo de información. Se afirma que la persona es un lamentable sistema de información; las máquinas en esto tienen su ventajas.

  20. Prügitelevisioonist / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    2004-01-01

    Kodumaiste kommertstelekanalite saated nagu "Vein ja seltskond", "Kaunis kaunimaks", "Nurgakivi", millele autor vastandab "arrogantse rämpsu" Esto TV saadete näol, kus "trash õilistub kõrgema aate kandjaks"

  1. Praenatalt diagnosticeret hydronefrose og andre urologiske anomalier

    DEFF Research Database (Denmark)

    Cortes, Dina; Jørgensen, Troels Munch; Rittig, Søren

    2006-01-01

    By renal ultrasound examination, urological anomalies may be demonstrated in 1-2% of fetuses and in about 0.5% of newborns. Boys have about twice the frequency of girls. Surgical treatment is indicated in about one fourth of these urological anomalies. If all pregnant women in Denmark were to hav...

  2. Miks paisub Avignon viis korda? / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2006-01-01

    Avignoni teatrifestivali OFF-programmist. Pikemalt Bernard-Marie Koltési näidendi "La nuit juste avant les forets" lavastusest (trupp Compagnie Pourquoi) ja lavastusest "Mascarade" (trupp Viva La Commedia)

  3. Action-teater on musi / Andres Noormets

    Index Scriptorium Estoniae

    Noormets, Andres, 1963-

    2007-01-01

    Lühike intervjuu action-teatriga kümmekond aastat tegelenud näitleja ja lavastajaga (improvisatsiooniline, füüsiline teatritreening ja etendamismeetod), mida tutvustab Viljandi Noore Tantsu festivali raames Eestis viibiv Ruth Zaporah

  4. Rakvere Teater ootab inimestelt munakive / Andres Pulver

    Index Scriptorium Estoniae

    Pulver, Andres, 1965-

    2003-01-01

    13. juunist 13. juulini etendab Rakvere Teater Neerutis A. Kivirähki "Kalevipoega". Sel puhul laseb teater kunstnik Simsonil (Simson von Seakyll) Neerutisse püsti panna Kalevipoja skulptuuri. Esimese kivi tõid telesaate "Subboteja" staarid, kes teevad Lääne-Virumaast erisaadet

  5. Res Publica kogub uut hoogu / Andres Jalak

    Index Scriptorium Estoniae

    Jalak, Andres, 1953-

    2005-01-01

    Kommenteerides Res Publica senise esimehe ja endise peaministri Juhan Partsi ning uueks esimeheks valitud Taavi Veskimäe kõnet Res Publica üldkogul, väljendab Res Publica fraktsiooni aseesimees usku, et Res Publica juhtimisel suudetakse 2007. aasta parlamendivalimistel taastada tulevikku suunatud mõtlemisega valitsus

  6. Plekktrummeldajate lastel on Stasi legendid / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2000-01-01

    50. Berliini filmifestivalil linastunud saksa režissööri Volker Schlöndorffi mängufilmist "Rita legendid" ja Tom Cruiseþi osatäitmisest Paul Thomas Andersoni filmis "Magnolia" : Ameerika Ühendriigid

  7. Linnahalli saatus taas savijalgadel / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2009-01-01

    Tallinnas viibis Tallinna Linnahalli ja selle ümbruse arendamisest huvituva Tallinn Entertainment LLC esindaja arhitekt Jack Weinand, kes kinnitas, et linnahalli väljanägemises ei tule muutusi. Tallinna ja Tallinn Entertainment LLC vahel sõlmitud eellepingust

  8. 1543-IJBCS-Article- Boya Andre

    African Journals Online (AJOL)

    hp

    paysanne d'adaptation aux effets de leur invasion par Chromolaena odorata au Bénin ... envahi, indispensables pour une gestion rationnelle des .... moyens de contrôle de plante et les diverses utilisations ..... Dynamique des paysages ...

  9. 3F og alle de andre

    DEFF Research Database (Denmark)

    Due, Jesper Jørgen; Madsen, Jørgen Steen

    Spørgsmålene stiller sig i kø, når man skal prøve at forklare den helt ekstraordinære forskel, der er på stemmeafgivningen om mæglingsforslaget i 3F sammenlignet med alle de øvrige omfattede LO-forbund. Det kan være svært at forstå, at 62 pct. af 3F's medlemmer, der deltog i afstemningen, vendte...... tommelfingeren ned, mens eksempelvis 66 pct. af Metals medlemmer, 65 pct. af TIB's medlemmer og 78 pct. af HK's medlemmer stemte ja til det samlede resultat af OK 2007....

  10. Areeni aasta album 2001 / Andres Lõo

    Index Scriptorium Estoniae

    Lõo, Andres, 1978-

    2001-01-01

    Areeni edetabel heliplaatidest: 1. N*E*R*D "In Search Of..."; 2. Moodymann "Forever-nevermore"; 3. Una Bomba "Aerosol"; 4. The Avalanches "Since I Left You"; 5. Blaze "Natural Blaze"; 6. Daft Punk "Discovery"; 7. The Strokes "Is This It"; 8. Cannibal Ox "The Cold Vein"; 9. Aphex Twin "Drukqs"; 10. Radiohead "Amnesiac"; 11. Super Furry Animals "Rings Around The World"; 12. The White Stripes "White Blood Cells"; 13. Ladytron "604"; 14. Spiritualized "Let It Come Down"; 15. Herbert "Bodily Functions"; 16. Mercury Rev "All Is Dream"; 17. Basement Jaxx "Rooty"; 18. Turin Brakes "The Optimist LP"; 19. Pulp "We Love Life"; 20. Mice Parade "Mokoondi".

  11. Kuressaare Hamlet on inglane / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2000-01-01

    29.oktoobril esilinastub Eesti Televisioonis Hamleti-teemaline ingliskeelne lühimängufilm "Miski on mäda ehk Kogu vale Hamletist" ("Something is Rotten or All the Lie About Hamlet") : režissöör, stsenarist ja produtsent Ilmar Raag : OÜ Kinomees 2000

  12. Kuressaare Hamlet ahistab Opheliat / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2000-01-01

    Ilmar Raag väntab Saaremaal Hamleti-teemalist ingliskeelset mängufilmi inglise näitlejatega esialgse pealkirjaga "Miski on riigis mäda ehk Kogu vale Hamletist" ("Something is Rotten or All the Lie About Hamlet". Filmi operaator on Madis Mihkelsoo ja kunstnik Liina Unt

  13. Udmurdi vägi / Andres Heinapuu

    Index Scriptorium Estoniae

    Heinapuu, Andres, 1954-

    2009-01-01

    Tänapäeva udmurdi kultuurist: emakeelsete raamatute kirjastamine, etnofuturism, Udmurtia PEN-klubi. Võrdlus maridega: udmurdid eelistavad poliitilisele vastasseisule keskvõimuga oma kultuuri arendamist

  14. Kõige keskkonnasõbralikum paik / Andres Tarand

    Index Scriptorium Estoniae

    Tarand, Andres, 1940-

    2004-01-01

    Ilmunud ka: Hiiu Leht, 19. nov. 2004, lk. 4; Põhjarannik, 19. nov. 2004, lk. 2; Severnoje Poberezhje, 19. nov. 2004, lk. 2; Pärnu Postimees, 24. nov. 2004, lk. 15; Nädaline, 25. nov. 2004, lk. 7; Valgamaalane, 30. nov. 2004, lk. 2; Meie Maa, 30. nov. 2004, lk. 5; Sotsiaaldemokraat, nov. 2004, nr. 98, lk. 5. Euroopa Parlamendi keskkonnakomisjonis arutlusel olevatest teemadest ja suurimatest keskkonnaprobleemidest

  15. "Vanamaterjali" projekt Patareis / Tarmo Andre Elvisto

    Index Scriptorium Estoniae

    Elvisto, Tarmo Andre, 1964-

    2016-01-01

    Säästva Renoveerimise Infokeskuse algatatud "Vanamaterjali projektist", mille eesmärk on päästa ja suunata korduvkasutusse kasutatud ehitusmaterjale ja -detaile. Vanamaterjali laost Patareis, seal pakutavast kaubast

  16. Eesti reklaamide best of... / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    2008-01-01

    Eesti reklaamikampaaniad: 1. http//www.assapauk.ee/. Mina olen pedofiil; 2. Vichy vesi. Mullnaised; 3. A le Coq Special. Usalda oma meeli; 4. SMS-laen. Kvaliteetinimene tarbib kvaliteetteenust; 5. Värska vurts. Preester ja koolitüdruk

  17. Via Hanseatica luubi all / Andres Loorand

    Index Scriptorium Estoniae

    Loorand, Andres, 1969-

    2006-01-01

    Jõgeval toimunud seminaril tutvustati saavutusi Baltimaade turismivõrgustiku väljatöötamisel Via Hanseatica arenguvööndis. Via Hanseatica maantee ulatub Balti riikides 688 km Panemunest (Leedu) Narvani, projekti koordineerib sihtasutus Lõuna-Eesti Turism

  18. Ärikeskus meelelahutajatele / Andres Haabu

    Index Scriptorium Estoniae

    Haabu, Andres

    2008-01-01

    Balti riikides suurim salvestusega CD- ja DVD-plaate tootev kontsern Baltic Optical Disc (BOD) Group tähistas muusika, filmi ja multimeedia valdkonnale pühendatud ärikeskuse laiendusosa ehitustööde alustamist nurgakivi panekuga Tallinnas Laagris 25. septembril

  19. Kultuuri kirjeldava meediasemiootika poole / Andres Kõnno

    Index Scriptorium Estoniae

    Kõnno, Andres

    2005-01-01

    Kommunikatsiooni kvaliteedi uurimisest meediumide ja auditooriumi vahel kujunevas ruumis, püstitades küsimuse meediasemiootika võimalustest ja arengusuundadest ning vajadusest seda vaadelda kultuurisemiootika raames

  20. Tantsud Tartus - vaatajast saab looja / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Festivalide Draama ja Eclectica tantsulavastustest : Krõõt Juuraku "Once Upon", Kaja Kannu, Martins Eiche ja Aigars Aipinsi "Vabadus/Briviba" ja Mairika Plakso ja Margus Toomla "The story of M & M Part II"

  1. Õhuruumi paindlik kasutamine / Andres Arendi

    Index Scriptorium Estoniae

    Arendi, Andres

    2007-01-01

    Eesti lennuliikluse suurenemine keskmiselt 8-10 protsenti aastas tingib üha efektiivsema õhuruumi kasutamise vajaduse. Õhuruumi paindliku kasutamise põhimõtetest. Kaardid. Tabel: Lennuliikluse dünaamika Eesti õhuruumis 1992-2006. Lisa: Lühendid ja mõisted

  2. Triennaali peavõidu sai Andres Tali

    Index Scriptorium Estoniae

    2001-01-01

    Tallinna 12. graafikatriennaalist. Peapreemia A. Tali tööle "Romeo ja Julia". Teisi premeeritud: Peeter Laurits, Ülle Marks, Jüri Kass, Vive Tolli, soomlane Janne Laine, lätlased Leonardas Laganovskis, Maltius Ratniks, Juris Boiko, Tif Bitmap

  3. Massachusetts Institute of Technology / Andres Sevtshuk

    Index Scriptorium Estoniae

    Sevtshuk, Andres, 1981-

    2006-01-01

    A. Sevtshuk oma magistritööst "The Self-aware City / Enesest teadlik linn". Juhendaja William J. Mitchell. Koolist Massachusetts Institute of Technology, selle arhitektuuriosakonnast, arhitektuuri teadusmagistrantuurist

  4. Teede ja vaimu infrastruktuur / Andres Kollist

    Index Scriptorium Estoniae

    Kollist, Andres, 1948-

    2013-01-01

    TLÜ AR direktor kirjutab, et riigikogu tasemel oleks vaja otsust, et rahvusraamatukogu ja kuue avalik-õigusliku ülikooli raamatukogud võivad digiteerida kõiki Eestis trükitud teavikuid. Trükiste digiteerimisest Norras. TLÜ AR on üles ehitamas digiteerimiskeskust

  5. Kas Euroopas olid CIA salavanglad? / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2006-01-01

    Dick Marty raportist USA Luure Keskagentuuri (CIA) oletatavatest salavanglatest Euroopas. Autor on seisukohal, et Euroopal tuleb igal juhul välja selgitada tõde CIA salavanglate olemasolu kohta, sest vastasel korral saab Venemaa argumendi inimõigustevastase tegevuse kaitseks. Vt. samas: CIA salavanglad ja -lennud Euroopas

  6. Digitaalse kirjaoskuseta enam ei saa / Andres Jõesaar

    Index Scriptorium Estoniae

    Jõesaar, Andres, 1959-

    2015-01-01

    Digikirjaoskusest, ristmeedia tootmisest. Hea lugu ja selle oskuslik edasiandmine digitehnoloogia vahendusel. Balti Filmi- ja Meediakooli ristmeedia tootmise bakalaureuse õppekava teise aasta tudengite tööst "Monsters to clowns", mis on lastega seotud ja lastele suunatud rahvusvaheline ristmeediaprojekt

  7. Keskkonnaraha kolis taotlejate juurde / Andres Pulver

    Index Scriptorium Estoniae

    Pulver, Andres, 1965-

    2005-01-01

    Keskkonnainvesteeringute keskus (KIK) avas maakondlikud esindused, mis abistavad projektide arendajaid keskkonnaprojektide toetuste taotlemisel, projektide elluviimisel ning kontrollivad toetuste sihipärast kasutamist. Lisa: KIK

  8. Kuidas Procter & Gamble kasvas suureks / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2004-01-01

    Maailma suurima esmatarbekaupade tootja Procter & Gamble arengust, kasvustrateegiast ja uue juhi Alan G. Lafley eesmärkidest ning tegevusest ettevõtte eesotsas. Vt. samas: Peakorter Läti asemel Eestisse?; Coca-Cola ja P&G ühisettevõte; Procter & Gamble tööstusspionaazhi kahtluse küüsis

  9. Kuningas tuli rahulikult tagasi / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    17. detsembril esilinastus maailma paljudes kinodes mängufilm "Sõrmuste isand : Kuninga tagasitulek" ("The Lord of the Rings : The Return of the King" : režissöör Peter Jackson : Ameerika Ühendriigid 2003

  10. Draamateater ja Theatrum Riias festivalil / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    1999-01-01

    Riias algas 25. okt. rahvusvaheline teatrifestival Homo Novus '99,kus Eestit esindavad Eesti Draamateater Priit Pedajase lavastusega "Mao tee kalju peal" ja Theatrum Lembit Petersoni lavastusega "Pelleas ja Melisande"

  11. Kaks vaadet Draamateatri "Kodukohale" / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2006-01-01

    Pakutakse kaks võimalust, kuidas kirjutada Draamateatri lavastusest "Kodukoht" Keila-Joa mõisas (arvustuste pealk. "Draamateater viib Keila-Joal võlumaailma" ja "Näide safe-bet-teatrist"). Mõlemad arvustuse tüübid mõnevõrra utreeritud

  12. Praenatalt diagnosticeret hydronefrose og andre urologiske anomalier

    DEFF Research Database (Denmark)

    Cortes, Dina; Jørgensen, Troels Munch; Rittig, Søren

    2006-01-01

    By renal ultrasound examination, urological anomalies may be demonstrated in 1-2% of fetuses and in about 0.5% of newborns. Boys have about twice the frequency of girls. Surgical treatment is indicated in about one fourth of these urological anomalies. If all pregnant women in Denmark were to hav...... in cases of urological anomalies and guidelines for post-natal diagnosis, follow-up and treatment of these anomalies, especially hydronephrosis....

  13. Eesti Pank edestab Saksa kolleegi / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2006-01-01

    Ajakiri Economist reastas maailma juhtriigid nende keskpankade töötajate ja riigi elanikkonna suhtarvu alusel. Ärilehe arvutuse põhjal on Eesti Balti riikidest väikseima suhtarvuga - 100 000 elaniku kohta on 17 keskpanga töötajat. Endine Hansapanga juht Indrek Neivelt leiab, et Eesti Panga töötajate arvu võiks vähendada üle kahe korra, Eesti Pank peab praegust töötajate arvu optimaalseks. Diagramm: Keskpanga töötajaid 100 000 elaniku kohta

  14. Er nogen mere lige end andre?

    DEFF Research Database (Denmark)

    Møberg, Rasmus Juul

    normativ fordring. Kohlis (2007) formulering af normalbiografien er en tredeling af livsforløbet (uddannelse – arbejdsliv - pension). En tredeling der bliver kritiseret for at være køns- og familieblind, hvorfor linked lives-begrebet bliver introduceret. Begrebet har den teoretiske implikation...... analyser tager højde for afhængighed over tid i den afhængige variabel. Overordnet set er det tre aspekter af datas karakteristika, der fordrer specielle metoder. Det er censurering af data, tidsmæssig variation i de uafhængige variable samt potentiel korrelation mellem målingerne af den afhængige variabel...... for disse ændringer, hvorved risikoen for en given transition beregnes mere præcist. Afhandlingens empiriske grundlag er registerdata for alle personer i Danmark, der tilhører fødselskohorterne 1968, 1972 og 1976. Data dækker over personlige, familiære forhold og oplysninger på arbejdspladsniveau, hvor den...

  15. Kümne kriitiku portreed / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2001-01-01

    Raamatust: 10 x 10 : 10 critics, 100 architects / autorid: Haig Beck, Jackie Cooper, Aaron Betsky, Roger Connah, Kristin Feireiss, Jorge Glusberg, Tom Heneghan, Mohsen Mostafavi, Terence Riley, Jaime Salazar, Neil Spiller. London : Phaidon, 2001

  16. Eesti Gaasiliit 2006. aastal / Andres Saar

    Index Scriptorium Estoniae

    Saar, Andres

    2007-01-01

    Ülevaade Eesti Gaasiliidu tegevusest - põhikiri, liikmeskond, juhtorganid, liidu tegevuse põhisuunad, õigus- ja normatiivaktid, propaganda, täienduskoolitus, kutseharidus, välissuhted, toimkondade töö, eelarve

  17. Tomheden i de andres liv chokerer mig

    DEFF Research Database (Denmark)

    Christiansen, Ask Vest

    2017-01-01

    ”Jeg tager mine ting ud af bilen og sætter cyklen sammen. Fra fortovsrestauranterne nysgerrige blikke fra turister og byens beboere. Ikke-cykelryttere. Det er frygteligt at tænke på, hvor indholdsløs deres tilværelse må være.” Sådan begynder Tim Krabbés bog Cykelrytteren. Den bedste roman der...

  18. Gaza võitmatu armaada / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    Katsest viia laevadega humanitaarabi Gaza sektorisse. Autor on arvamusel, et kui Vabaduse laevastik ongi saavutanud soovitu ja murdnud blokaadi, siis uus tasakaal pole julgeoleku mõttes sugugi kindlam

  19. Vsemirnõi atom / Andre Illing

    Index Scriptorium Estoniae

    Illing, Andre

    2008-01-01

    Autori hinnangul on vaja alustada infrastruktuuri loomist energeetilise süsteemi revolutsiooniliseks muutmiseks. Perspektiivsemate tulevikuprojektide tutvustus (termotuumasüntees, nanotehnoloogilised päikeseelemendid, mikrobioloogiline energeetika jt)

  20. Juri Jerjomini lavastused suvel Tallinnas / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2006-01-01

    5.-7. juulini mängitakse Estonia teatris Mossoveti teatris valminud Juri Jerjomini lavastusi - Fjodor Dostojevski ja Ivan Turgenevi teoste põhjal "Mees, naine ja armuke" ja Tennessee Williamsi "Tramm nimega iha"

  1. Film Diegost - kriitikavaba kummardus / Andres Must

    Index Scriptorium Estoniae

    Must, Andres

    2007-01-01

    PÖFFi filme - Argentiina mängufilm legendaarse jalgpalluri Diego Maradona jumaldamisest "Teel Maradona juurde" ("El camino de San Diego") : stsenarist ja režissöör Carlos Sorin. Artikkel on peamiselt Maradonast, vähesel määral filmist

  2. Maksude langus on trend / Andres Lipstok

    Index Scriptorium Estoniae

    Lipstok, Andres, 1957-

    2004-01-01

    Ilmunud ka: Delovõje Vedomosti 14. apr. lk. 10; Paremad Uudised apr. nr. 4 lk. 7. Autor analüüsib Eesti maksupoliitikat ning leiab, et nii ettevõtluse maksustamise vähendamine kui üksikisiku tulumaksu alandamine on hädavajalik riigi majanduse elavdamiseks ning Eesti majandusliku arengu viimiseks EL-i liikmesriikide tasemele

  3. Kuidas Canon suureks kasvas / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2004-01-01

    Jaapani kaamerate ja büroomasinate tootja Canon Groupi arengust, tegevusest kolmes regioonis - USA-s, Euroopas ja Aasias ning ettevõtte pikaajalise edu põhjustest - ärifilosoofiast ning ajastatud tootearendusest. Vt. samas: Firma esialgne nimi oli Kwanon; Konkurendid koonduvad

  4. BRS finantseerib ise miljardilise raudteeostu / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2001-01-01

    Raudtee erastaja Baltic Rail Service osanikud tasuvad miljardikroonise ostusumma omavahenditest augustikuu viimasel nädalal, mis nullib riigikontrolöri tänaseks kavandatud rünnaku Eesti Raudtee erastamisele

  5. Ralph Fiennes on Coriolanus / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2010-01-01

    Berliini filmifestivalil väljaspool võistlusprogrammi linale jõudvast filmist "Coriolanus". Ralph Fiennes mängib peaosas ja on filmi lavastaja. Tegemist on W. Shakespeare'i "Coriolanuse" ekraniseeringuga, mis on kujunduse poolest toodud tänapäeva

  6. Eesti joonisfilm torgib paljastustega / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2006-01-01

    23. nov. PÖFFi raames toimuval animafilmifestifalil "Animated Dreams"esilinastus neli uut eesti animafilmi : Ülo Pikkovi "Elu maitse", Kaspar Jancise "Maraton", Elisabeth Salmini "Elu võimalikkusest arbuusil" ja üks osa - "Taimne direktor" (režii Priit Tender) Eesti Joonisfilmis töös olevast seitsmest lühifilmist koosnevast filmist "Must lagi"

  7. DVD-d. "Libahundi needus" / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2006-01-01

    Mängufilm "Libahundi needus" : stsenaristid Margus Kasterpalu, Ilmar Raag ja Rainer Sarnet : režissöör Rainer Sarnet : osades Katariina Lauk, Rene Reinumägi : Shop of Dreams - Eesti Televisioon 2005

  8. Vene faktor ehk poloonium 210 / Andres Herkel

    Index Scriptorium Estoniae

    Herkel, Andres, 1962-

    2007-01-01

    Autor mõtestab lahti nn pärsitud kriitika sündroomi, mille järgi Mihhail Gorbatshovist alates on Vene võimu saatnud üks kustumatu müüt: Vene võimuga peab leppima, sest olukord on plahvatusohtlik ja uus, mis tuleb, on kindlasti hullem

  9. "Borati" filmil enneolematu menu kinodes / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2006-01-01

    Briti koomiku Sacha Baron Coheni loodud peategelasega USA film "Borat - kultuurialased õppetunnid Ameerikast abiks suursuguse Kasahstani riigi ülesehitamisel" kogus Eesti kinolevis avanädalavahetusel 12 487 vaatajat (taasiseseisvumisaja neljas tulemus). Edukas on film ka mujal maailmas

  10. At samle på de Andre

    DEFF Research Database (Denmark)

    Danbolt, Mathias

    2017-01-01

    I de seneste par år har der været heftige diskussioner i danske medier om brugen af raciale stereotyper på indpakningen af såkaldte kolonialvarer i supermarkederne. Kritikken af billedernes racistiske effekter er ofte blevet afvist med påstanden om, at det er absurd at tale om racisme i mødet med...... noget så hverdagsagtigt som emballagen på kaffe, kakao eller chokolade. Men kikker man den danske mærkevarehistorie i kortene, står det klart at reklamebilleders påvirkningskraft ikke er til at spøge med. Mærkevareindustrien har været central i udbredelsen og normaliseringen af racistiske forståelser af...

  11. Aaviku fenomen = The Aaviku Phenomenon / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2003-01-01

    Aaviku elamurajoonist, kus on 67 maja, 6 erinevat tüüpi, ühe- ja kahekorruselised, 84-144 mø suured, hindadega vahemikus 760000-1200000 krooni. Projekteerija: Arhitektuuribüroo Emil Urbel. Autorid Emil Urbel ja Indrek Erm. Konstruktor Otto Pukk (OMK Inseneribüroo). Haljastus: Maria Pukk, Ivar Lubjak (Oaas Arhitektid). Projekt 2000-2001, valmis 2001-2003. Tüüpprojekti S-5 I ja II korruse plaan, tüüpprojekti V-2 põhiplaan, sisevaade, 5 välisvaadet

  12. Must lill heidab suure varju / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2007-01-01

    Brian De Palma krimimüsteerium "Must daalia" ("The Black Dahlia"), mis põhineb James Ellroy samanimelisel romaanil : operaator Vilmos Zsigmond : osades Josh Hartnett, Aaron Eckhart, Hilary Swank, Scarlett Johansson : Ameerika Ühendriigid 2006. Film noir'i stilistika kasutamisest filmis

  13. Uuno Turhapuro taas kinoekraanil / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2004-01-01

    Komöödiafilm "Uuno Turhapuro - This is my life" : režissöör Ere Kokkonen : nimiosas Vesa-Matti Loiri : Soome 2004. See on sama peategelasega 19. film. Kõigi eelnevate filmide produtsent oli mõne aasta eest surnud Spede Pasanen

  14. Andre liv på egen krop

    DEFF Research Database (Denmark)

    Ahl, Sofie Isager

    2015-01-01

    the connections (and disconnections), that the winemakers experience in relation to the vines and wines. The study is inspired by theories that can be linked to “multispecies ethnography” (Kirksey & Helmreich 2010) – notably the work of Eduardo Kohn (2013), Philippe Descola (2005) and Tim Ingold (2000, 2012...

  15. Virginia Woolfi tunnid kummitavad edasi / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    Virginia Woolfi teosest "Mrs. Dalloway" ajendatud Michael Cunninghami romaanil "Tunnid" põhinev mängufilm "Tunnid" ("The Hours") : režissöör Stephen Daldry : kesksetes rollides Meryl Streep, Nicole Kidman, Julianne Moore : Suurbritannia 2002

  16. Eesti kajas saksa Baltoscandalil / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    12. juunil alanud saksa festivalist Transeuropa 2003, kus esinejateks ka Von Krahli Teater lavastusega "Pirates", K. Essenson sooloetendusega "So far, so good" ja kunstikriitik ja -kuraator A.Härm performance'iga "Be drunk, be very, very drunk"

  17. Eesti teater esineb Transeuropa festivalil / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    12. juunil algab Saksamaal Hildesheimis festival Transeuropa 2003, kus esineb Von Krahli Teater lavastusega "Pirates", K. Essenson tantsib oma sooloetendust "So far, so good" ja kunstikriitik ja -kuraator A.Härm korraldab performance'i "Be drunk, be very, very drunk"

  18. Pankrotti taotleb ka Travel In / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2010-01-01

    Reisikorraldaja Travel In Tours esitas pankrotiavalduse. Tarbijakaitseamet on teinud firmale ettekirjutuse seoses võltsitud tagatisega ning on küsinud majandustegevuse registrist andmeid kõikide Eesti reisikorraldajate tagatiste kohta

  19. Venelaste tarbimisjanu kasvatab Muuga transiiti / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2008-01-01

    Muuga CT ja Tallinna Sadam investeerivad üle 2 miljardi krooni Muuga CT konteinerterminali laiendamiseks, Venemaale suunduvate konteinerrongide arvu soovitakse mitmekordistada. Eesti Raudtee peab konteinervedusid oma prioriteediks

  20. Boligstandarden i plejehjem og andre institutioner

    DEFF Research Database (Denmark)

    Gottschalk, Georg

    Boligstandarden i plejehjem og institutioner for handicappede diskuteres meget for tiden. Denne rapport er den første landsdækkende undersøgelse af boligstandarden i plejehjem, beskyttede boliger og institutioner for voksne med handicap. Den indeholder blandt andet oplysninger om, hvor store være...

  1. Kliimamuutuste mõju laboratoorium / Andres Tarand

    Index Scriptorium Estoniae

    Tarand, Andres, 1940-

    2001-01-01

    Segadused Ida-Aafrika riikides, nende põhjused. Tabel: Ida-Aafrika riikide mõned arengunäitajad: Etioopia, Sudaan, Somaali, Burundi, Rwanda, Uganda, Tanzania, Keenia. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik

  2. 1374-IJBCS-Article-Tibiri Andre

    African Journals Online (AJOL)

    KODJIO NORBERT

    The determination of total phenolic and tannins contents, .... A. −. = ×. ; where I is the percentage of inhibition, A0 absorbance of control, As the absorbance of the sample. For .... governs the synthesis of abnormal S .... Pratical manual on.

  3. Ühemeheteater sammub peateele / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2006-01-01

    Baltoscandal 2006 : Liibanoni näitleja, lavastaja, näitekirjanik Rabih Mroue etendus "Looking for a Missing Employee", Mark Ravenhilli monolavastus "Product" ja sloveen Emil Hrvatin' ühemeheetendus "Miss Mobile"

  4. Kolmepoolne koostöölepe Tehnikaülikooli, OÜ TTÜ Sport ja SEB Ühispanga vahel

    Index Scriptorium Estoniae

    2006-01-01

    Tallinna Tehnikaülikool rektor Peep Sürje, Osaühing TTÜ Sport juhatuse esimees Andres Öpik ja AS SEB Eesti Ühispank juhatuse esimees Mart Altvee allkirjastasid kolmepoolse koostöölepingu, milles nähakse ette ühistegevused TTÜ üliõpilastele õppekavadega seotud äriplaanikonkursi korraldamisel, üliõpilaste sporditegevuse edasiarendamisel ning üliõpilastele osutatud pangateenuste parandamisel

  5. Implementación de las tics como estrategia didáctica para generar un aprendizaje significativo de los procesos celulares en los estudiantes de grado sexto de la institución educativa San Andrés del municipio de Girardota

    OpenAIRE

    Monsalve Ochoa, Martha Lía

    2012-01-01

    Esta práctica docente se hizo con el objetivo de aplicar herramientas TIC a una serie de estudiantes de la institución educativa san Andrés de la vereda del mismo nombre del municipio de Girardota. Son jóvenes entre 11 y 15 años de escasos recursos en su mayoría, con poco apoyo de sus padres para la motivación hacia el estudio, en la institución no se cuenta con laboratorio ni material alguno para la práctica de las ciencias. No son jóvenes que le vean mucha importancia a esta área porque nin...

  6. Visitantes florais de Erythrina speciosa Andr. (Leguminosae Flowering visitors of Erythrina speciosa Andr., Leguminosae

    Directory of Open Access Journals (Sweden)

    Maria J. Vitali-Veiga

    2000-06-01

    Full Text Available Inspite of Etythrina species exhibit morphologic attributes for adaptation to pollination by nectarivorous birds mentioned in the literature, E. speciosa is pollinated by lots of bees (Apinae and Meliponinae which show a great urban occurrence. Systems of E. speciosa floral reproduction, fenology, diversity, frequency and constancy of insects visiting at different hours and flowering periods were studied. E. speciosa is Biocompatible, but xenogamy is the predominant system of reproduction. A large diversity of insects visiting the inflorescences was observed, with predominance of bees. The bee species showed a higher frequency: Apis mellifera Linnaeus, 1758 (45,0 %, Trigona spinipes (Fabricius, 1793 (28,6%, Trigona hyalinata (Lepeletier, 1836 (12,2 % and the ant Zacryptoceruspusillus Klug, 1824 (2,8 %. Constant but not frequent were the bees (Apidae Plebeia droryana (Friese, 1900, Friesella schrottkyi (Friese, 1900, Nannotrigona testaceicornis (Lepeletier, 1836, Tetragonisca angustula (Latreille, 1811, the wasps (Vespidae Polybia paulista Ihering, 1896, Protopolybia exigua (de Saussure, 1854, Agelaia pallipes (Olivier. 1791, the ant (Formicidae Pseudomyrmex sp. and the beetle (Chrysomelidae Diabrotica speciosa (Germar, 1824. E. speciosa flowers were visited by hummingbirds (Trochilidae: Eupetomena macroura (Gmelin, 1788, Clorostilbon aureoventris (d'Orbigny & Lafresnaye, 1838 and Amazilia sp. The birds Passer domeslicus (Linnaeus, 1758 (Ploceidae and Coereba flaveola (Linnaeus, 1758 (Emberizidac, also are present. The frequency and insect distribution were influenced by ambiental factors. Temperature, light, time, barometric pressure, relative humidity and wind velocity were significantly correlated with insect numbers. There is a visit sequence, by floral resource disponibility during the day, conditioned by transport ability, insect numbers and colony necessity, which begins by A. mellifera followed by meliponid bees. These bees make the pollination when they collect the pollen. There is a great animal variety which are sustained by flowers. It is suggested that E. speciosa is one important food source for urban fauna in winter, and so it should be utilized more frequently in streets, parks and gardens arborization.

  7. Policonsumo simultâneo de drogas entre estudantes de graduação da área de ciências da saúde de uma universidade: implicações de gênero, sociais e legais, Santo André - Brasil

    Directory of Open Access Journals (Sweden)

    Maria do Perpétuo Socorro de Sousa Nóbrega

    2012-01-01

    Full Text Available Estudio transversal que busca comprender los patrones de poli-consumo simultáneo de drogas y sus consecuencias de genero, sociales y legales entre estudiantes universitarios. 275 estudiantes de las ciencias de la salud de pregrado de una universidad en Santo André, Brasil participaran en el estudio. El policonsumo simultáneo estuvo presente en 27,9% de los estudiantes de la muestra. Combinaciones: alcohol + marihuana; alcohol + medicamentos de prescripción; alcohol + tabaco + cannabis; tabaco + cannabis; y tabaco + medicamentos de prescripción. Razones: Para relajarse, perder inhibiciones, mantenerse despierto, ayudar a hacer algo que genera molestia y mejorar el efecto de otras sustancias. No se observó asociación entre circunstancias jurídicas y sociales, los hombres presentaron mayor poli-consumo que las mujeres, y la religión se presentó como un factor de protección para el poli-consumo, que fue menor que la encontrada en la literatura. Dado que se trata de futuros profesionales de la salud, las políticas institucionales deben ser analizadas con el fin de reducir la exposición y la vulnerabilidad a estas sustancias psicoactivas.

  8. "Que nunca chegue o dia que irá nos separar": notas sobre epistémê arcaica, hermafroditas, andróginos, mutilados e suas (descontinuidades modernas "May it never come the day that will tear us apart": notes About classical epistémê, hermaphrodites, androgynous, mutilated people and their modern (discontinuities

    Directory of Open Access Journals (Sweden)

    Jorge Leite Jr.

    2009-12-01

    Full Text Available A figura do hermafrodita ou andrógino foi fundamental para todo o discurso médico-moral-espiritual sobre sexo e gênero em nossa cultura, desde a Antiguidade até o século XVIII. Com a mudança epistemológica que ocorre a partir do século XVI, o antigo hermafrodita, associado ao mundo mágico e religioso, perde seu lugar nas classificações modernas. A partir do século XIX nasce uma nova entidade conceitual no Ocidente: o pseudo-hermafrodita da medicina, não mais "maravilha" da natureza, mas um erro desta; filho do racionalismo iluminista e do positivismo, vindo a tornar-se o pai - e mãe - das futuras identidades transgêneras.The image of the hermaphrodite or androgyne was essential for all medical-moral-spiritual discourses about sex and gender in our culture, from Antiquity until the eighteenth century. With the epistemological change that has happened since the sixteenth century, the old hermaphrodite, associated with the magical and religious world, has lost his/her place in modern classifications. From the nineteenth century on, a new conceptual entity in the West takes place: the pseudo-hermaphrodite from medicine, not the wonder of nature anymore, but its error; a product of the illuminist rationalism and positivism, gradually becoming the father and mother of future transgender identities.

  9. André Thibault, Perfecto simple y perfecto compuesto en español preclásico. Estudio de los perfectos de indicativo en "La Celestina", el "Teatro" de Encina y el "Dialogo de Ia lengua". Beihefte zur ZRPh, Band 301, Max Niemeyer Verlag, Tübingen 2000; págs.

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    2001-12-01

    Full Text Available La suerte del perfectum latino en lenguas románicas no deja de atraer a los investigadores de los problemas sintácticos. Suenan como profecía las palabras con las cuales el Autor concluyó su trabajo diciendo que en este campo queda todavía mucho por hacer; la profecía parece válida no solo para el español, sino para todo el mundo romance. Prof. André Thibault ha restringido su investigación sobre el pretérito simple y compuesto (permítaseme la terminologia a la cual estoy acostumbrado a los tres grandes acontecimientos en la literatura española, indicados en el título, pero antepuso a su trabajo un amplio panorama histórico, incluyendo en ello anotaciones sobre las tendencias en algunos idiomas indoeuropeos que demuestran los usos de las formas simples y las compuestas y no sólo en el campo del pretérito.

  10. Typification de quelques taxons d'orobanches ('Orobanchaceae')

    OpenAIRE

    Jeanmonod, Daniel

    2007-01-01

    Dans le cadre d'une étude sur les Orobanches de Corse, cinq taxons sont lectotypifiés: Orobanche castellana Reut. (= Orobanche amethystea subsp. castellana (Reut.) Rouy), Orobanche rapum var. bracteosa Reut. (= Orobanche rapum-genistae Thuill.), Orobanche rigens f. corsica Beck (= Orobanche rigens Loisel.), Orobanche rigens var. nigricans Beck (= Orobanche rigens Loisel.) et Phelypaea mutelii var. nana Reut. (≡Phelipanche nana (Rchb. f.) Soják). Tous ces lectotypes sont déposés dans les herbi...

  11. The estimation of production rates of $\\pi^+K^-, \\pi^-K^+$ and $\\pi^+\\pi^-$ atoms in proton-nucleus interactions at 450 GeV/c

    CERN Document Server

    Gorchakov, O

    2015-01-01

    Short-lived (τ ∼ 3 × 10 − 15 s) π+ K− , K+ π− and π+ π− atoms as well as long- lived (τ ≥ 1 × 10 − 11 s) π+ π− atoms produced in proton-nucleus interactions at 24 GeV/c are observed and studied in the DIRAC experiment at the CERN PS. The purpose of this paper is to show that the yields of the short-lived π+ K−, K+ π− and π+ π− atoms in proton-nucleus interactions at 450 GeV/c and θ lab = 4◦ are estimated to be, respectively, 17, 38 and 16 times higher per time unit. This may allow significantly improving the precision of their lifetime measurement and ππ and πK scattering length combinations |a0 − a2| and |a 1/2 − a3/2| . The yields of the long-lived π+ K− , K+ π− and π+ π− atoms at 450 GeV/c are estimated to be 370, 1600 and 750 times higher than at 24 GeV/c. This may allow the resonance method to be used for measuring the Lamb shift in the ππ atom and a new ππ scattering length combination 2 a0 + a2 to be obtained.

  12. Inter-specific relationships among two Tunisian Thymus taxa ...

    African Journals Online (AJOL)

    Genetic relationships between two sympatric species Thymus capitatus Hoffm. et Link. and Thymus algeriensis Boiss. et Reut. (Thymus hirtus Willd. subsp. algeriensis Boiss. et Reut.) were assessed using random amplified polymorphic DNA (RAPD) markers. Eighteen natural populations from different geographical and ...

  13. Territorial Indicative Budget Ceilings (PIK as Instrument of Technocracy of Regional Development Planning

    Directory of Open Access Journals (Sweden)

    Sarjiyanto Sarjiyanto

    2017-03-01

    Full Text Available This research aims at analyzing the local government policy related to the local budget posture in the each territorial. There are uncertainty methods in dividing and formulating the local budget posture in each territorial in Indonesia. It is not depend on the actual economic variables of each territorial. This study uses the literature studies to collect the data of planning and budgeting. The content analysis of this local government economic policy is based on of the planning and budgeting process itself. The detailed information is found by observations and in-depth interview with the informants about the planning and budgeting process in Rembang. The result shows the variables that can determine the fair instrument in formulating the local budget posture some of which are: the number of population, the number of drop out (DO, the illiteracy (IR, the infant mortality rate (IMR, the malnutrition data, the number of poor (HCI, the economic growth, the damaged road infrastructure, the damaged irrigation system, the damaged schools, the land building tax, and the amount of retribution.

  14. Particle identification aerogel counter with n=1.13 for {pi}/K separation

    Energy Technology Data Exchange (ETDEWEB)

    Barnyakov, A.Yu.; Barnyakov, M.Yu. [Budker Institute of Nuclear Physics, 11, akademika Lavrentieva prospect, Novosobirsk 630090 (Russian Federation); Beloborodov, K.I., E-mail: K.I.Beloborodov@inp.nsk.s [Budker Institute of Nuclear Physics, 11, akademika Lavrentieva prospect, Novosobirsk 630090 (Russian Federation); Novosibirsk State University, 2, Pirogova Street, Novosibirsk 630090 (Russian Federation); Bobrovnikov, V.S.; Buzykaev, A.R. [Budker Institute of Nuclear Physics, 11, akademika Lavrentieva prospect, Novosobirsk 630090 (Russian Federation); Danilyuk, A.F. [Boreskov Institute of Catalysis, 5, akademika Lavrentieva prospect, Novosibirsk 630090 (Russian Federation); Golubev, V.B. [Budker Institute of Nuclear Physics, 11, akademika Lavrentieva prospect, Novosobirsk 630090 (Russian Federation); Novosibirsk State University, 2, Pirogova Street, Novosibirsk 630090 (Russian Federation); Kirillov, V.L. [Boreskov Institute of Catalysis, 5, akademika Lavrentieva prospect, Novosibirsk 630090 (Russian Federation); Kononov, S.A. [Budker Institute of Nuclear Physics, 11, akademika Lavrentieva prospect, Novosobirsk 630090 (Russian Federation); Kravchenko, E.A. [Budker Institute of Nuclear Physics, 11, akademika Lavrentieva prospect, Novosobirsk 630090 (Russian Federation); Novosibirsk State University, 2, Pirogova Street, Novosibirsk 630090 (Russian Federation); Onuchin, A.P. [Budker Institute of Nuclear Physics, 11, akademika Lavrentieva prospect, Novosobirsk 630090 (Russian Federation); Martin, K.A. [Budker Institute of Nuclear Physics, 11, akademika Lavrentieva prospect, Novosobirsk 630090 (Russian Federation); Novosibirsk State Technical University, 20, Karl Marx prospect, Novosibirsk 630092 (Russian Federation); Serednyakov, S.I. [Budker Institute of Nuclear Physics, 11, akademika Lavrentieva prospect, Novosobirsk 630090 (Russian Federation); Novosibirsk State University, 2, Pirogova Street, Novosibirsk 630090 (Russian Federation)

    2010-11-01

    The paper is devoted to the cosmic muon tests of particle identification system for the SND detector at the new VEPP-2000 e{sup +}e{sup -} collider. The goal of the tests is to measure average signal for the relativistic particles. The measurements of the average signal were done at five different points of the counter. Obtained values of the signal are close to 10 photoelectrons. Preliminary results for misidentification probability for {pi} and K mesons with the energy of 1000 MeV are presented.

  15. Tunnustame tõenduspõhise õendusabi edendajaid / Ester Öpik, Ilme Aro

    Index Scriptorium Estoniae

    Öpik, Ester

    2014-01-01

    Tunnustati meditsiiniõdesid Tiina Freimanni, Reet Urbanit, Marika Asbergi, Tiina Tõemetsa, Kersti Viitkarit ja Ireen Bruusi Eesti Õdede Liidu poolt 2011. aastani kaitstud õendusteaduslike uurimistööde eest

  16. New POLDI - project of reincarnation of a polarized neutron diffractometer at the reactor PIK

    Science.gov (United States)

    Zobkalo, I.; Gavrilov, S.; Matveev, V.; Fenske, J.

    2017-06-01

    The project of a considerable modernization of the polarized neutron diffractometer POLDI is discussed. It assumes the adoption of POLDI to a broader range of magnetic investigations such as determination of magnetic structures, detailed investigation of complex magnetic structures, studies of magnetic domains, study of the magnetization density maps, magnetic form-factor particularities, local susceptibility, etc. The flexible construction should permit to use either spherical neutron polarimetry technique or flipping ratio technique. Different types of polarization system were analyzed. Original focusing fan-like bender is proposed as polarizer unit. Our simulations give evidence that for the wavelength range 1.3 - 3 Å and with suitable size, such a device can give much better efficiency than 3He cells, which are often in use. The higher flux at the sample position of a factor of at least 3.3, with lower divergence and good polarization degree from 98% (1.3 Å) to above 94% (3 Å) makes the bender set-up favorable over the layout with a 3He-cell.

  17. Reduction of greenhouse gases emissions listed in the Kyoto Protocol by the utilization of landfill gas using solid oxide fuel cells; Reducao das emissoes de gases de efeito estufa listados no protocolo de Quioto pelo aproveitamento do gas gerado em aterros sanitarios utilizando celulas a combustivel de oxido solido. Estudo de caso do aterro municipal de Santo Andre, SP, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Paris, Alexandre Gellert

    2007-07-01

    In the last few years, the Kyoto Protocol had been a subject very debated, at first, in a restricted niche, manly academics and professionals related to the area of climate changes. On 16th February 2005 the Kyoto Protocol entered into force and with this a lot of publicity all over the world, so today is common to hear about it at the mass communications media. The extension of the subject is broad, this work discuss the utilization of one the Kyoto's flexibility mechanisms, to contribute to financing the use of the landfill gas in the solid oxide fuel cells. Among the three mechanisms presented in the Kyoto Protocol, the clean development mechanism (CDM) in article 12, is the only one that can be implemented by non-Annex I countries, the case of Brazil. In other hand, the issue of solid waste in Brazil is critical. Even being illegal, most of the solid waste goes to uncontrolled areas in open air places 'lixoes', causing degradation of the environment and the communities around this areas, and also emission of green house gases (GHG), deregulating the global climate system. Decontaminate this areas and the construction of landfills to replace than, considering the landfill as a bioreactor, and the utilization of the biogas to generate power can improve nowadays picture that we are facing. The utilization of an innovative alternative technology as the solid oxide fuel cell (SOFC) instead the conventional technologies will be more efficient and environmentally better. Among other barriers the cost is pointed as the biggest. In this context, the SOFC is the most expensive fuel cell, so the utilization of CDM can contribute to finance the application of this technology. Scenarios were made of 250 kW, 500 kW, 1,000 kW, 5,000 kW and 10,000 kW of installed power using biogas from the Municipal Landfill of Santo Andre. The calculations of the emission factor were done ex ante and ex post according to ACM0002. Comparing the costs of the installed power studied and the

  18. Reduction of greenhouse gases emissions listed in the Kyoto Protocol by the utilization of landfill gas using solid oxide fuel cells; Reducao das emissoes de gases de efeito estufa listados no protocolo de Quioto pelo aproveitamento do gas gerado em aterros sanitarios utilizando celulas a combustivel de oxido solido. Estudo de caso do aterro municipal de Santo Andre, SP, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Paris, Alexandre Gellert

    2007-07-01

    In the last few years, the Kyoto Protocol had been a subject very debated, at first, in a restricted niche, manly academics and professionals related to the area of climate changes. On 16th February 2005 the Kyoto Protocol entered into force and with this a lot of publicity all over the world, so today is common to hear about it at the mass communications media. The extension of the subject is broad, this work discuss the utilization of one the Kyoto's flexibility mechanisms, to contribute to financing the use of the landfill gas in the solid oxide fuel cells. Among the three mechanisms presented in the Kyoto Protocol, the clean development mechanism (CDM) in article 12, is the only one that can be implemented by non-Annex I countries, the case of Brazil. In other hand, the issue of solid waste in Brazil is critical. Even being illegal, most of the solid waste goes to uncontrolled areas in open air places 'lixoes', causing degradation of the environment and the communities around this areas, and also emission of green house gases (GHG), deregulating the global climate system. Decontaminate this areas and the construction of landfills to replace than, considering the landfill as a bioreactor, and the utilization of the biogas to generate power can improve nowadays picture that we are facing. The utilization of an innovative alternative technology as the solid oxide fuel cell (SOFC) instead the conventional technologies will be more efficient and environmentally better. Among other barriers the cost is pointed as the biggest. In this context, the SOFC is the most expensive fuel cell, so the utilization of CDM can contribute to finance the application of this technology. Scenarios were made of 250 kW, 500 kW, 1,000 kW, 5,000 kW and 10,000 kW of installed power using biogas from the Municipal Landfill of Santo Andre. The calculations of the emission factor were done ex ante and ex post according to ACM0002. Comparing the costs of the installed power

  19. Female genealogies in André Brink's Imaginings of Sand

    African Journals Online (AJOL)

    Tienie

    an army of ants which crawl all over her. On the other hand, while admitting that there is “a different socialization of the body”, some feminists have .... beach and left behind its foam and in the sun it turned into a woman. But that we don't know for sure and I prefer to talk only about the things I know (174). Another kind of ...

  20. Tampere Teattrerikesä algas veidi teispoolselt / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2005-01-01

    Soomes alanud teatrifestivalist Tampere teatrisuvi. Pikemalt A. Raivio "Viimasest karavanist" Q-teatteri esituses, M. Ivashkeviciuse " Poisikesest" Korshunovase Teatri ja Vilniuse Linnateatri koostöös ning sakslaste norton.commander.productions lavastusest "Solaris"