Er:YAG Laser and Fractured Incisor Restorations: An In Vitro Study

Directory of Open Access Journals (Sweden)

C. Fornaini

2012-01-01

Full Text Available Introduction. The aim of this study was to analyse the effects of an Er:YAG laser on enamel and dentine in cases of dental restorations involving fractured teeth, utilizing the dental fragment. Materials and Methods. Seventy-two freshly extracted bovine incisors were fractured at the coronal level by using a hammer applied with a standardized method, and the fragment was reattached by using three different methods: Er:YAG laser, orthophosphoric acid, and laser plus acid. The different groups were evaluated by a test realized with the dynamometer to know the force required to successfully detach the reattached fragment and by a microinfiltration test by using a 0.5% methylene blue solution followed by the optic microscope observation. Results. The compression test showed only a slight difference between the three groups, without any statistical significance. The infiltration test used to evaluate the marginal seal between the fracture fragment and the tooth demonstrated that etching with Er:YAG laser alone or in combination with orthophosphoric acid gives better results than orthophosphoric acid alone, with a highly significant statistical result. Discussion. Reattaching a tooth fragment represents a clinically proven methodology, in terms of achieving resistance to detachment, and the aim of this work was to demonstrate the advantages of Er:YAG laser on this procedure. Conclusion. This “in vitro” study confirms that Er:YAG laser can be employed in dental traumatology to restore frontal teeth after coronal fracture.

The Los Alamos National Laboratory Environmental Restoration Program

International Nuclear Information System (INIS)

Krueger, J.W.

1990-01-01

The LANL Environmental Restoration (ER) Program Office, established in October 1989, is faced with the challenge of assessing and cleaning up nearly 1,8000 potentially hazardous waste sites according to an aggressive corrective action schedule that the Environmental Protection Agency (EPA) mandated on May 23, 1990, in a Resource, Conservation, and Recovery Act (RCRA) Part B Permit. To maximize program efficiency, the ER Program Office will implement a unique management approach designed to maximize the use of laboratory technical expertise. The Installation Work Plan, which provides a blueprint for the program, has been submitted to EPA for review and approval. A work plan for characterization of Technical Area 21, an early plutonium processing facility, is also nearing completion. The feasibility of an expedited cleanup of the Laboratory's worst hazardous waste release has been modelled using a computer code originally developed by LANL to assist the nuclear weapons testing program. A sophisticated Geographic Information System has been implemented to assist in data management and presentation, and the design of a Mixed Waste Disposal Facility is underway. 6 refs., 2 figs

Environmental restoration and waste management: Robotics technology development program: Robotics 5-year program plan

International Nuclear Information System (INIS)

1991-01-01

This plan covers robotics Research, Development, Demonstration, Testing and Evaluation activities in the Program for the next five years. These activities range from bench-scale R ampersand D to full-scale hot demonstrations at DOE sites. This plan outlines applications of existing technology to near-term needs, the development and application of enhanced technology for longer-term needs, and initiation of advanced technology development to meet those needs beyond the five-year plan. The objective of the Robotic Technology Development Program (RTDP) is to develop and apply robotics technologies that will enable Environmental Restoration and Waste Management (ER ampersand WM) operations at DOE sites to be safer, faster and cheaper. Five priority DOE sites were visited in March 1990 to identify needs for robotics technology in ER ampersand WM operations. This 5-Year Program Plan for the RTDP detailed annual plans for robotics technology development based on identified needs. In July 1990 a forum was held announcing the robotics program. Over 60 organizations (industrial, university, and federal laboratory) made presentations on their robotics capabilities. To stimulate early interactions with the ER ampersand WM activities at DOE sites, as well as with the robotics community, the RTDP sponsored four technology demonstrations related to ER ampersand WM needs. These demonstrations integrated commercial technology with robotics technology developed by DOE in support of areas such as nuclear reactor maintenance and the civilian reactor waste program. 2 figs

Information management architecture for an integrated computing environment for the Environmental Restoration Program. Environmental Restoration Program, Volume 3, Interim technical architecture

International Nuclear Information System (INIS)

1994-09-01

This third volume of the Information Management Architecture for an Integrated Computing Environment for the Environmental Restoration Program--the Interim Technical Architecture (TA) (referred to throughout the remainder of this document as the ER TA)--represents a key milestone in establishing a coordinated information management environment in which information initiatives can be pursued with the confidence that redundancy and inconsistencies will be held to a minimum. This architecture is intended to be used as a reference by anyone whose responsibilities include the acquisition or development of information technology for use by the ER Program. The interim ER TA provides technical guidance at three levels. At the highest level, the technical architecture provides an overall computing philosophy or direction. At this level, the guidance does not address specific technologies or products but addresses more general concepts, such as the use of open systems, modular architectures, graphical user interfaces, and architecture-based development. At the next level, the technical architecture provides specific information technology recommendations regarding a wide variety of specific technologies. These technologies include computing hardware, operating systems, communications software, database management software, application development software, and personal productivity software, among others. These recommendations range from the adoption of specific industry or Martin Marietta Energy Systems, Inc. (Energy Systems) standards to the specification of individual products. At the third level, the architecture provides guidance regarding implementation strategies for the recommended technologies that can be applied to individual projects and to the ER Program as a whole

Technical support to the ER program subsurface technologies team leader. Final report, March 15, 1993--March 15, 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-12-01

This research included development of a new geologic sample management facility and associated quality assurance systems for the LANL Environmental Restoration Program. Additional work with the LANL Environmental Restoration Program included the development of Sampling and Analysis Plans (SAP) for various Operable Units for the Laboratory. The PI (Davidson) served as the sample curation/sample management specialist on the ER program Subsurface Studies Technical Team. Specialization in Field Unit Data Base systems was the focus of the work towards the end of the contract. A document is included which provides the Statement of Policy for the management of borehole samples collected during environmental restoration activities at LANL.

Technical support to the ER program subsurface technologies team leader. Final report, March 15, 1993 - March 15, 1998

International Nuclear Information System (INIS)

1998-01-01

This research included development of a new geologic sample management facility and associated quality assurance systems for the LANL Environmental Restoration Program. Additional work with the LANL Environmental Restoration Program included the development of Sampling and Analysis Plans (SAP) for various Operable Units for the Laboratory. The PI (Davidson) served as the sample curation/sample management specialist on the ER program Subsurface Studies Technical Team. Specialization in Field Unit Data Base systems was the focus of the work towards the end of the contract. A document is included which provides the Statement of Policy for the management of borehole samples collected during environmental restoration activities at LANL

Oak Ridge Reservation Federal Facility Agreement for the Environmental Restoration Program. Volume 1, Quarterly report, October--December 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-01-01

This Oak Ridge Reservation Federal Facility Agreement Quarterly Report for the Environmental Restoration Program was prepared to satisfy requirements for progress reporting on Environmental Restoration Program (ER) activities as specified in the Oak Ridge Reservation Federal Facility Agreement (FFA) established between the US Department of Energy (DOE), the US Environmental Protection Agency, and the Tennessee Department of Environment and Conservation. The reporting period covered in this document is October through December 1995. This work was performed under Work Breakdown Structure 1.4.12.2.3.04 (Activity Data Sheet 8304). Publication of this document meets two FFA milestones. The FFA Quarterly Report meets an FFA milestone defined as 30 days following the end of the applicable reporting period. Appendix A of this report meets the FFA milestone for the Annual Removal Action Report for the period FYs 1991--95. This document provides information about ER Program activities conducted on the Oak Ridge Reservation under the FFA. Specifically, it includes information on milestones scheduled for completion during the reporting period, as well as scheduled for completion during the next reporting period (quarter); accomplishments of the ER Program; concerns related to program work; and scheduled activities for the next quarter. It also provides a listing of the identity and assigned tasks of contractors performing ER Program work under the FFA.

Los Alamos National Laboratory environmental restoration program group audit report for underground storage tank removal: Audit ER-92- 04, July 22--August 11, 1992

International Nuclear Information System (INIS)

Gillespie, P.F.

1992-01-01

Audit ER-92-04 was conducted on activities being performed by Waste Management (EM-7), Environmental Protection (EM-8), and Environmental Restoration (EM-13) groups for the LANL's underground storage tank removal program. Scope of the audit was limited to an evaluation of the implementation of the State of New Mexico requirements for underground storage-tank removal. Activities were evaluated using requirements specified in the State of New Mexico Environmental Improvement Board Underground Storage Tank Regulations, EIB/USTR. Two recommendations are made: (1) that a single organization be given the responsibility and authority for the implementation of the program, and (2) that the requirements of the NM State environmental improvement board underground storage tank regulations be reviewed and a Los Alamos procedure written to address requirements and interfaces not contained in SOP-EM7-D ampersand D-001

Adaptive Long-Term Monitoring at Environmental Restoration Sites (ER-0629)

Science.gov (United States)

2009-05-01

Printed on recycled paper TECHNICAL REPORT TR-2317-ENV ADAPTIVE LONG-TERM MONITORING AT ENVIRONMENTAL RESTORATION SITES (ER-0629...nondetect values. One curiosity is that the typical recent RL for TCE has been 0.5, whereas that for PCE has been 1.4. As a consequence, and due to...Spring 2000 makes little difference, however. A curiosity is that the anomalous value from Spring 2006 is actually quite similar to the early

Guidance document for the preparation of waste management plans for the Environmental Restoration Program at Oak Ridge National Laboratory

International Nuclear Information System (INIS)

Clark, C. Jr.

1993-07-01

A project waste management (WM) plan is required for all Oak Ridge National Laboratory (ORNL) Environmental Restoration (ER) Program remedial investigation, decommission and decontamination (D ampersand D), and remedial action (RA) activities. The project WM plan describes the strategy for handling, packaging, treating, transporting, characterizing, storing, and/or disposing of waste produced as part of ORNL ER Program activities. The project WM plan also contains a strategy for ensuring worker and environmental protection during WM activities

Identification of remediation needs and technology development focus areas for the Environmental Restoration (ER) Project at Sandia National Laboratories/New Mexico (SNL/NM)

International Nuclear Information System (INIS)

Tucker, M.D.

1995-06-01

The Environmental Restoration (ER) Project has been tasked with the characterization, assessment, remediation and long-term monitoring of contaminated waste sites at Sandia National Laboratories/New Mexico (SNL/NM). Many of these sites will require remediation which will involve the use of baseline technologies, innovative technologies that are currently under development, and new methods which will be developed in the near future. The Technology Applications Program (TAP) supports the ER Project and is responsible for development of new technologies for use at the contaminated waste sites, including technologies that will be used for remediation and restoration of these sites. The purpose of this report is to define the remediation needs of the ER Project and to identify those remediation needs for which the baseline technologies and the current development efforts are inadequate. The area between the remediation needs and the existing baseline/innovative technology base represents a technology gap which must be filled in order to remediate contaminated waste sites at SNL/NM economically and efficiently. In the first part of this report, the remediation needs of the ER Project are defined by both the ER Project task leaders and by TAP personnel. The next section outlines the baseline technologies, including EPA defined Best Demonstrated Available Technologies (BDATs), that are applicable at SNL/NM ER sites. This is followed by recommendations of innovative technologies that are currently being developed that may also be applicable at SNL/NM ER sites. Finally, the gap between the existing baseline/innovative technology base and the remediation needs is identified. This technology gap will help define the future direction of technology development for the ER Project

Comparison of Microleakage of Glass Ionomer Restoration in Primary Teeth Prepared by Er: YAG Laser and the Conventional Method

Directory of Open Access Journals (Sweden)

M. Ghandehari

2012-01-01

Full Text Available Objective: One of the main criteria in evaluating the restorative materials is the degree of microleakage. The aim of this study was to compare the microleakage of glass ionomer restored cavities prepared by Er:YAG laser or turbine and bur.Materials and Methods: Twenty extracted caries-free deciduous posterior teeth were selected for this study. The teeth were randomly divided into two groups for cavity preparation. Cavities in group one were prepared by high speed turbine and bur. In the second group, Er:YAG laser with a 3W output power, 300 mJ energy and 10 Hz frequency was used. Cavities were restored with GC Fuji II LC. After thermocycling, the samples were immersed into 0.5% methylene blue solution. They were sectioned for examination under optic microscope.Results: The Wilcoxon signed ranks test showed no significant difference between microleakage of the laser group and the conventional group (P>0.05.Conclusion: Er:YAG laser with its advantages in pediatric dentistry may be suggested as an alternative device for cavity preparation.Key Words: Er:YAG laser, Glass ionomer, Microleakage

Requirements for quality control of analytical data for the Environmental Restoration Program

International Nuclear Information System (INIS)

Engels, J.

1992-12-01

The Environmental Restoration (ER) Program was established for the investigation and remediation of inactive US Department of Energy (DOE) sites and facilities that have been declared surplus in terms of their previous uses. The purpose of this document is to Specify ER requirements for quality control (QC) of analytical data. Activities throughout all phases of the investigation may affect the quality of the final data product, thus are subject to control specifications. Laboratory control is emphasized in this document, and field concerns will be addressed in a companion document Energy Systems, in its role of technical coordinator and at the request of DOE-OR, extends the application of these requirements to all participants in ER activities. Because every instance and concern may not be addressed in this document, participants are encouraged to discuss any questions with the ER Quality Assurance (QA) Office, the Analytical Environmental Support Group (AESG), or the Analytical Project Office (APO)

Environmental Restoration Program pollution prevention performance measures for FY 1993 and 1994 remedial investigations

International Nuclear Information System (INIS)

1993-03-01

The Martin Marietta Energy Systems, Inc., Environmental Restoration (ER) Program adopted a Pollution Prevention Program in March 1991. The program's mission is to minimize waste and prevent pollution in remedial investigations (RI), feasibility studies (FS), decontamination and decommissioning (D ampersand D), and surveillance and maintenance (S ampersand M) site program activities. Mission success will result in volume and/or toxicity reduction of generated waste. Energy Systems is producing a fully developed a Numerical Scoring System (NSS) and actually scoring the generators of Investigation Derived Waste (IDW) at six ER sites: Oak Ridge National Laboratory (ORNL), the Oak Ridge Y-12 Plant, the Oak Ridge K-25 site, Paducah Gaseous Diffusion Plant (Paducah), and Portsmouth Uranium Enrichment Complex (Portsmouth). This report summarizes the findings of this initial numerical scoring evaluation and shows where improvements in the overall ER Pollution prevention program may be required. This report identifies a number of recommendations that, if implemented, would help to improve site-performance measures. The continued development of the NSS will support generators in maximizing their Pollution Prevention/Waste Minimization efforts. Further refinements of the NSS, as applicable suggest comments and/or recommendations for improvement

Idaho National Engineering Laboratory (INEL) Environmental Restoration (ER) Program Baseline Safety Analysis File (BSAF)

International Nuclear Information System (INIS)

1995-09-01

The Baseline Safety Analysis File (BSAF) is a facility safety reference document for the Idaho National Engineering Laboratory (INEL) environmental restoration activities. The BSAF contains information and guidance for safety analysis documentation required by the U.S. Department of Energy (DOE) for environmental restoration (ER) activities, including: Characterization of potentially contaminated sites. Remedial investigations to identify and remedial actions to clean up existing and potential releases from inactive waste sites Decontamination and dismantlement of surplus facilities. The information is INEL-specific and is in the format required by DOE-EM-STD-3009-94, Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports. An author of safety analysis documentation need only write information concerning that activity and refer to BSAF for further information or copy applicable chapters and sections. The information and guidance provided are suitable for: sm-bullet Nuclear facilities (DOE Order 5480-23, Nuclear Safety Analysis Reports) with hazards that meet the Category 3 threshold (DOE-STD-1027-92, Hazard Categorization and Accident Analysis Techniques for Compliance with DOE Order 5480.23, Nuclear Safety Analysis Reports) sm-bullet Radiological facilities (DOE-EM-STD-5502-94, Hazard Baseline Documentation) Nonnuclear facilities (DOE-EM-STD-5502-94) that are classified as open-quotes lowclose quotes hazard facilities (DOE Order 5481.1B, Safety Analysis and Review System). Additionally, the BSAF could be used as an information source for Health and Safety Plans and for Safety Analysis Reports (SARs) for nuclear facilities with hazards equal to or greater than the Category 2 thresholds, or for nonnuclear facilities with open-quotes moderateclose quotes or open-quotes highclose quotes hazard classifications

Idaho National Engineering Laboratory (INEL) Environmental Restoration (ER) Program Baseline Safety Analysis File (BSAF)

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-01

The Baseline Safety Analysis File (BSAF) is a facility safety reference document for the Idaho National Engineering Laboratory (INEL) environmental restoration activities. The BSAF contains information and guidance for safety analysis documentation required by the U.S. Department of Energy (DOE) for environmental restoration (ER) activities, including: Characterization of potentially contaminated sites. Remedial investigations to identify and remedial actions to clean up existing and potential releases from inactive waste sites Decontamination and dismantlement of surplus facilities. The information is INEL-specific and is in the format required by DOE-EM-STD-3009-94, Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports. An author of safety analysis documentation need only write information concerning that activity and refer to BSAF for further information or copy applicable chapters and sections. The information and guidance provided are suitable for: {sm_bullet} Nuclear facilities (DOE Order 5480-23, Nuclear Safety Analysis Reports) with hazards that meet the Category 3 threshold (DOE-STD-1027-92, Hazard Categorization and Accident Analysis Techniques for Compliance with DOE Order 5480.23, Nuclear Safety Analysis Reports) {sm_bullet} Radiological facilities (DOE-EM-STD-5502-94, Hazard Baseline Documentation) Nonnuclear facilities (DOE-EM-STD-5502-94) that are classified as {open_quotes}low{close_quotes} hazard facilities (DOE Order 5481.1B, Safety Analysis and Review System). Additionally, the BSAF could be used as an information source for Health and Safety Plans and for Safety Analysis Reports (SARs) for nuclear facilities with hazards equal to or greater than the Category 2 thresholds, or for nonnuclear facilities with {open_quotes}moderate{close_quotes} or {open_quotes}high{close_quotes} hazard classifications.

The development and application of a risk-based prioritization model for the Oak Ridge Environmental Restoration Program

International Nuclear Information System (INIS)

Dail, J.L.; White, R.K.

1995-01-01

The Oak Ridge Environmental Restoration (ER) Program developed and implemented the Environmental Restoration Benefit Assessment Matrix (ERBAM) early in 1994 to provide a simple, efficient process for prioritizing and justifying fiscal budget decisions for a diverse set of activities. The decision to develop a methodology for prioritizing sites was necessitated by the large number of buildings and areas managed by the DOE Oak Ridge Field Office and the finite resources available to address these areas. The ERBAM was based on the Integrated Resource Management System prioritization methodology historically used by the United States Department of Energy (DOE) and Lockheed Martin Energy Systems, Inc., to rank compliance and operational activities. To develop the matrix, ER Program management, working with federal and state regulators, agreed on impact criteria that balance the major objectives within the ER Program: protection of public health, protection of the environment, protection of on-site workers, consideration of stakeholder/community preference, achievement of ER mission, and optimization of cost efficiency. Lessons learned from the initial application of the matrix were used to make refinements and improvements in the methodology. A standard set of assumptions (both overall and categoric) and a prioritization board, consisting of top level DOE and Lockheed Martin Energy Systems, Inc., managers along with federal and state regulatory representatives, were established to facilitate consistent application. Current and future improvements include a method to incorporate existing quantitative risk data and facilitate increased efficiency in applying baseline cost data and approved funding levels to the prioritized output. Application of the prioritization methodology yields a prioritized list of all work activities within the programs' work breakdown structure

Strategic plan and strategy of the Oak Ridge National Laboratory Environmental Restoration Program

International Nuclear Information System (INIS)

1995-06-01

This report provides information about the use of an integrated strategic plan, strategy, and life-cycle baseline in the long range planning and risk process employed by the environmental restoration program at the Oak Ridge National Laboratory (ORNL). Long-range planning is essential because the ER Program encompasses hundreds of sites; will last several decades; and requires complex technology, management, and policy. Long-range planning allows a focused, cost-effective approach to identify and meet Program objectives. This is accomplished through a strategic plan, a strategy, and a life-cycle baseline. This long-range methodology is illustrated below

Effects of Er, Cr:YSGG laser irradiation on external adaptation of restorations in caries-affected cavities

International Nuclear Information System (INIS)

Tonetto, Mateus Rodrigues; Saad, José Roberto Cury; Campos, Edson Alves de; Neto, Sizenando de Toledo Porto; De Andrade, Marcelo Ferrarezi; Bandéca, Matheus Coelho; Borges, Alvaro Henrique; Pinto, Shelon Cristina Souza

2013-01-01

This study evaluated the effect of Er,Cr:YSGG laser irradiation on the external adaptation of composite resin restorations in caries-affected cavities. Mixed class V cavity preparations were performed in 36 intact human third molars, in half of which caries was artificially induced. Both healthy and carious dentin were etched with 35% phosphoric acid (Ultradent Products Inc., South Jordan, Utah, USA), and the teeth were divided into three groups, i.e., (a) untreated etched dentin, (b) application of the Er, Cr:YSGG laser and (c) use of chlorhexidine as an adjunct in the bonding process. Restorations were fabricated with Z350 XT FiltekTM composite resin (3M ESPE) and subsequently the specimens were subjected to thermocycling to simulate artificial ageing. Quantitative analysis of external adaptation was performed by scanning electron microscopy in both healthy and affected dentin using epoxy resin replicas. It was concluded that the application of laser and chlorhexidine did not affect the percentages of marginal adaptation of class V restorations. Furthermore, thermocycling may influence adaptation values. (letter)

The remediation process: Approach and elements of the Department of Energy's environmental restoration program in a Superfund environment

International Nuclear Information System (INIS)

Lehr, J.C.

1993-01-01

The Department of Energy (DOE) operates a large industrial complex located at various production, processing, testing, and research and development installations across the country. During the 40+ years of operation, this complex generated and managed waste to then-current standards. However, some of these waste management practices have subsequently been proven to be inadequate for long-term environmental protection. The Office of Environmental Restoration and Waste Management (EM) was established in 1989, when DOE's top priority changed from nuclear weapons production to environmental cleanup. The Environmental Restoration (ER) Program within EM was tasked to ensure that risks to human health and the environment posed by DOE's past operations at its nuclear facilities and sites are eliminated or reduced to prescribed, safe levels. Since its creation, the ER Program has been one of the fastest growing programs in the Department, demonstrating the Secretary's commitment to the new clean-up priority. (The 1989 budget was $400 million, while the 1993 budget is $1.8 billion.) As new technologies are developed and new management strategies implemented, the program will continue to expand. This paper describes the environmental remediation process from its early assessment phase to the final compliance effort

Characterization of hazardous waste residuals from Environmental Restoration Program activities at DOE installations: Waste management implications

International Nuclear Information System (INIS)

Lazaro, M.A.; Esposito, M.P.

1995-01-01

Investigators at Argonne National Laboratory (ANL), with support from associates at the Pacific Northwest Laboratory (PNL), have assembled an inventory of the types and volumes of radioactive, toxic or hazardous, and mixed waste likely to be generated over the next 30 years as the US Department of Energy (DOE) implements its nationwide Environmental Restoration (ER) Program. The inventory and related analyses are being considered for integration into DOE's Programmatic Environmental Impact Statement (PEIS) covering the potential environmental impacts and risks associated with alternative management practices and programs for wastes generated from routine operations. If this happens, the ER-generated waste could be managed under a set of alternatives considered under the PEIS and selected at the end of the current National Environmental Policy Act process

FY 1994 annual summary report of the surveillance and maintenance activities for the Oak Ridge National Laboratory Environmental Restoration Program

International Nuclear Information System (INIS)

1994-11-01

The Oak Ridge National Laboratory (ORNL) Environmental Restoration (ER) Surveillance and Maintenance (S and M) Program was initiated to manage former waste management and environmental research sites contaminated with radioactive materials and/or hazardous chemicals. The S and M Program is responsible for managing designated sites/facilities from the end of their operating lives until final disposition or site stabilization. To effectively manage and perform the various S and M Program responsibilities, five summary-level work breakdown structure (WBS) elements have been established: S and M Preliminary Investigations, Special Projects, Routine S and M, Inactive Groundwater Wells, and Project Management. Routine S and M activities were conducted as scheduled throughout fiscal years (FY) 1994 at applicable inactive waste management (WM) and other contaminated areas. Overall, the ER S and M Program maintains 47 facilities, performs vegetation maintenance on approximately 230 acres, maintains 54 inactive tanks, and provides overall site management on over 700 acres. In addition to the routine S and M activities, detailed site inspections were conducted at established frequencies on appropriate sites in the ER S and M Program. This document provides a summary of the FY 1994 ORNL ER S and M Program accomplishments

Environmental restoration/waste management-applied technology semiannual report, January--June 1992

International Nuclear Information System (INIS)

Adamson, M.; Kline-Simon, K.

1992-01-01

This is the first issue from the Lawrence Livermore National Laboratory of The Environmental Restoration/Waste Management-Applied Technology (ER/WM-AT) Semiannual Report, a continuation of the Advanced Processing Technology (APT) Semiannual Report. The name change reflects the consolidation of the APT Program with the Environmental Restoration and Waste Management Program to form the Environmental Restoration/Waste Management-Applied Technology (ER/WM-AT) Program. The Livermore site mirrors, on a small scale, many of the environmental and waste management problems of the DOE Complex. The six articles in this issue cover incineration- alternative technologies, process development for waste minimization, the proposed Mixed Waste Management Facility, dynamic underground stripping, electrical resistance tomography, and Raman spectroscopy for remote characterization of underground tanks

Design Program in Graphic User Interface Environment for Automobile ER Devices

Science.gov (United States)

Lim, S. C.; Park, J. S.; Sohn, J. W.; Choi, S. B.

This work presents a design and analysis program for vehicle devices utilizing an electrorheological (ER) fluid. The program is operated in graphic user interface (GUI) environment and the initial window is consisted of four subprogram modules which are related to ER shock absorber, ER seat damper, ER engine mount, and ER anti-lock brake system (ABS), respectively. In order to execute each module, both material properties and design parameters are to be chosen by the user. Then, the output display window shows the field-dependent performance characteristics to be considered as design criteria. In addition, control performances of the vehicle system equipped with ER devices are displayed in time and frequency domain. In order to demonstrate the effectiveness of the proposed program, ER shock absorber and ER ABS are designed and manufactured and their performance characteristics are evaluated.

Marginal microleakage evaluation in class V composite restorations of deciduous teeth prepared conventionally and using Er:YAG laser

International Nuclear Information System (INIS)

Pulga, Neusa Vieira Galvao

2001-01-01

The evaluation of marginal microleakage in class V restorations of deciduous teeth prepared using Er:laser and comparison to the ones observed when conventionally prepared, using two photopolimerizable materials, composite resin and glass ionomer cement, was the subject of this study. Twenty eight complete deciduous teeth were divided into four groups Group 1 (G1) prepared with high speed drill + composite resin; Group 2 (G2) prepared with high speed drill + glass ionomer cement; Group 3 (G3) prepared using Er:YAG laser (2.94 μm), 300 mJ, 3 Hz, handpiece 2051, energy density 86 mJ/cm 2 + composite resin; Group 4 (G4) prepared using Er:YAG laser (2.94 μm), 300 mJ, 3 Hz, handpiece 2051, energy density 86 J / cm 2 + glass ionomer cement. After the preparation and restoration the specimens where stored at 37 deg C for 24 hours, thermally stressed, immersed in 50% aqueous solution of silver nitrate for 24 hours while kept in the dark. The specimens were rinsed in water, soaked in photodeveloping solution and exposed to fluorescent light for 6 hours. After this process the samples were sectioned and observed by stereomicroscopy. For comparison the groups were divided into occlusive and cervical microleakage. The results were analysed under the Kruskal-Wallis test. For the occlusive microleakage the statistical significance was 5% among the groups and the average comparison showed higher microleakage for G1 (M=35.1) than for G2 (M=24.0) as well as compared to G3 (M=22.3). The other groups did not present statistical differences among them. For the cervical microleakage the Kruskal-Wallis test did not present any statistical difference. Comparing the occlusive and cervical microleakage data, for every group, using the Wilcoxon test, no statistical differences were observed. Concluding, this study showed the Er:YAG laser to be effective for class V restorations and to result in a smaller microleakage degree using the composite resin. These results indicate the viability

Effect of type of cavity preparation (bur,Er:YAG laser and restorative materials on prevention of caries lesion

Directory of Open Access Journals (Sweden)

Masumeh Hasani Tabatabaei

2017-03-01

Full Text Available Background and Aims: Despite the reduction of incidence of dental caries in recent years, this disease is common and many efforts were conducted to decrease the prevalence of dental caries. On the other hand secondary caries lesions are the main reason for replacement of direct restorations. Therefore, the aim of the current study was to evaluate suitable methods of preparation and restorative materials to reduce caries recurrence. Materials and Methods: In this experimental study, eighty human teeth were collected and stored in normal saline. The teeth were soft-tissue debrided and cleaned with water/pumice slurry and rubber cups in a low-speed handpiece. Speciments were randomly divided in two main groups. Cavities were prepared with diamond burs or Er:YAG laser (10 Hz, 300 mJ, 3W. Each group was divided into 4 sub-groups, and restored with a glass-ionomer cement (Fuji IX, resin modified glass-ionomer (Fuji II LC, total etch bonding + composite resin or self-etch bonding + composite resin. The specimens were submitted to pH cycling. Speciments were then sectioned, polished and Vickers microhardness measurements were performed on each specimen. Differences among the medians were analyzed using two way ANOVA test at a 95% confidence level and Tukey test. Results: Statistical analysis showed significant difference in the type of substrate (enamel, dentin in both main groups (P<0.0001 but no differences in the caries lesion development between the cavities restored with the same material and prepared with diamond burs or Er:YAG laser. Conclusion: The Er:YAG laser used for cavity preparation and different types of restorative materials used did not show the ability to guarantee significantly more acid-resistance tooth structure against demineralization.

Evaluation of enamel mineral loss around cavities prepared by the Er,Cr:YSGG laser and restored with different materials

Science.gov (United States)

Navarro, Ricardo Scarparo; Lago, Andréa. Dias Neves; Bonifácio, Clarissa Calil; Mendes, Fausto Medeiros; de Freitas, Patrícia Moreira; Baptista, Alessandra; Nunez, Silvia Cristina; Matos, Adriana Bona; Imparato, José Carlos P.

2018-02-01

The aim of this study was to evaluate the enamel demineralization around cavities prepared by Er,Cr:YSGG laser (2780 nm) and restored with different materials after an acid challenge. The human dental enamel samples were randomly divided in 12 groups (n=10): G1- high-speed drill (HD); G2- Er,Cr:YSGG laser L (3 W, 20 Hz, 53.05 J/cm2)(air 65% - water 55%); G3- L (4 W, 20 Hz, 70.74 J/cm2); G4- L (5 W, 20 Hz, 88.43 J/cm2). Each group was divided in subgroups: 1- glass ionomer cement (GIC), 2- resin modified GIC (RMGIC), 3- composite resin (C). Samples were submitted to an acid challenge (4.8 pH) for7 days. The calcium ion contend (ppm/mm2) from demineralizing solutions were analyzed by atomic emission spectrometry. ANOVA and LSD tests were performed (α=5%). The significant lower average values of calcium loss were observed on G2 + GIC, G2 + RMGIC, G1 + RMGIC (penamel demineralization. The findings of this in vitro study suggest that the Er,Cr:YSGG lased cavities restored with GIC or RMGIC or conventional drill cavities with RMGIC were effective on reducing the demineralization around restorations, showing an important potential in preventing secondary caries.

Waste management/waste certification plan for the Oak Ridge National Laboratory Environmental Restoration Program

International Nuclear Information System (INIS)

Clark, C. Jr.; Hunt-Davenport, L.D.; Cofer, G.H.

1995-03-01

This Waste Management/Waste Certification (C) Plan, written for the Environmental Restoration (ER) Program at Oak Ridge National Laboratory (ORNL), outlines the criteria and methodologies to be used in the management of waste generated during ORNL ER field activities. Other agreed upon methods may be used in the management of waste with consultation with ER and Waste Management Organization. The intent of this plan is to provide information for the minimization, handling, and disposal of waste generated by ER activities. This plan contains provisions for the safe and effective management of waste consistent with the U.S. Environmental Protection Agency's (EPA's) guidance. Components of this plan have been designed to protect the environment and the health and safety of workers and the public. It, therefore, stresses that investigation derived waste (IDW) and other waste be managed to ensure that (1) all efforts be made to minimize the amount of waste generated; (2) costs associated with sampling storage, analysis, transportation, and disposal are minimized; (3) the potential for public and worker exposure is not increased; and (4) additional contaminated areas are not created

Planning for and managing environmental restoration waste

International Nuclear Information System (INIS)

Miller, J.Q.

1993-01-01

This paper describes the approach used to support the management of environmental restoration (ER) waste. A general description is provided of the tools and techniques that have been developed and applied to produce waste generation forecast data and treatment, storage, and disposal capacity needs. The ER Program can now consistently manage ER waste streams from initial generation through ultimate disposal. Utilizing the valuable information that results from application of strategically planned systems and techniques demonstrates the ability to provide the necessary waste management support for the ER cleanup process

Environmentally Sensitive Areas Surveys Program threatened and endangered species survey: Progress report. Environmental Restoration Program

Energy Technology Data Exchange (ETDEWEB)

King, A.L.; Awl, D.J.; Gabrielsen, C.A.

1994-09-01

The Endangered Species Act (originally passed in 1973) is a Federal statute that protects both animal and plant species. The Endangered Species Act identifies species which are, without careful management, in danger of becoming extinct and species that are considered threatened. Along with the designation of threatened or endangered, the Endangered Species Act provides for the identification of appropriate habitat for these species. Since 1993, the United States Department of Energy`s (DOE) Environmental Restoration (ER) Program has supported a program to survey the Oak Ridge Reservation (ORR) for threatened and endangered species. The Environmentally Sensitive Areas Surveys Program initiated vascular plant surveys during fiscal year 1993 and vertebrate animal surveys during fiscal year 1994 to determine the baseline condition of threatened and endangered species on the ORR at the present time. Data collected during these surveys are currently aiding Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Remedial Investigations on the ORR. They also provide data for ER and Waste Management decision documents, ensure that decisions have technical and legal defensibility, provide a baseline for ensuring compliance with principal legal requirements and will increase public confidence in DOE`s adherence to all related environmental resources rules, laws, regulations, and instructions. This report discusses the progress to date of the threatened and endangered species surveys of the ORR.

Oak Ridge Reservation Site Management Plan for the Environmental Restoration Program

International Nuclear Information System (INIS)

1991-09-01

This site management for the Environmental Restoration (ER) Program implements the Oak Ridge Reservation (ORR) Federal Facility Agreement (FFA) (EPA 1990), also known as an Interagency Agreement (IAG), hereafter referred to as ''the Agreement.'' The Department of Energy (DOE), the US Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC), hereafter known as ''the Parties,'' entered into this Agreement for the purpose of coordinating remediation activities undertaken on the ORR to comply with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) as amended by the Superfund Amendments, the Resource Conservation and Recovery Act (RCRA), and the National Environmental Policy Act (NEPA). 7 refs., 17 figs

Floristic Quality Index of Restored Wetlands in Coastal Louisiana

Science.gov (United States)

2017-08-01

ER D C/ EL T R- 17 -1 5 Ecosystem Management and Restoration Research Program Floristic Quality Index of Restored Wetlands in Coastal...of Wisconsin Lake Plant Communities with Example Applications. Lake and Reservoir Management 15(2): 133-141. Rocchio, J. 2007. Floristic Quality ... quality in Ohio wetlands. Science of the Total Environment 551: (556-562). Steyer, G. D., and R. E. Stewart, Jr. 1992. Monitoring Program for Coastal

Environmental restoration and waste management: Robotics technology development program: Robotics 5-year program plan

International Nuclear Information System (INIS)

1991-01-01

This plan covers robotics Research, Development, Demonstration, Testing, activities in the Program for the next five years. These activities range from bench-scale R ampersand D to fullscale hot demonstrations at DOE sites. This plan outlines applications of existing technology to near-term needs, the development and application of enhanced technology for longer-term needs, and an initiation of advanced technology development to meet those needs beyond the five-year plan. The objective of the Robotic Technology Development (RTDP) is to develop and apply robotics technologies that will enable Environmental Restoration and Waste Management operations at DOE sites to be safer, faster and cheaper. Five priority DOE sites were visited in March 1990 to identify needs for robotics technology in ER ampersand WM operations. This 5-Year Program Plan for the RTDP detailed annual plans for robotics technology development based on identified needs. This 5-Year Program Plan discusses the overall approach to be adopted by the RTDP to aggressively develop robotics technology and contains discussions of the Program Management Plan, Site Visit and Needs Summary, Approach to Needs-Directed Technical Development, Application-Specific Technical Development, and Cross-Cutting and Advanced Technology. Integrating application-specific ER ampersand WM needs, the current state of robotics technology, and the potential benefits (in terms of faster, safer, and cheaper) of new technology, the Plan develops application-specific road maps for robotics RDDT ampersand E for the period FY 1991 through FY 1995. In addition, the Plan identifies areas where longer-term research in robotics will have a high payoff in the 5- to 20-year time frame. 12 figs

Fiscal year 1990 Rocky Flats Plant environmental restoration program current-year work plan

International Nuclear Information System (INIS)

Nielsen, T.; Waage, E.; Miller, D.

1990-01-01

This paper reports on the FY90 Current Year Work Plan (CYWP), intended to serve as a guiding document with which the Environmental Restoration and RCRA Compliance programs will be implemented at the Rocky Flats Plant, The Current Year Work Plan document serves to provide in one single document any cross-references necessary to understand how the DOE Five Year Plan, Site Specific Plan, or any other related documents fit into the Current Year Work Plan for the Rocky Flats Environmental Restoration. The scope of this paper will compare the planned Fiscal Year 1990 environmental restoration activities to those actually achieved at the end of the fiscal year. The DOE Headquarters (HQ) issued the Environmental Restoration and Waste Management (ER/WM) Five-Year Plan (FYP). The purpose of the FYP is to establish an agenda for compliance and cleanup against which progress will be measured. The Five Year Plan has been updated to include the Colorado Department of Health (CDH), Evironmental Protection Agency (EPA), and Department of Energy (DOE) Inter Agency Agreement Environmental Restoration activities. It addresses hazardous wastes, radioactive wastes, mixed wastes (radioactive and hazardous), and sanitary wastes. It also addresses facilities and sites contaminated with or used in the management of those wastes

Electronic document management system analysis report and system plan for the Environmental Restoration Program

International Nuclear Information System (INIS)

Frappaolo, C.

1995-09-01

Lockheed Martin Energy Systems, Inc. (LMES) has established and maintains Document Management Centers (DMCs) to support Environmental Restoration Program (ER) activities undertaken at three Oak Ridge facilities: Oak Ridge National Laboratory, Oak Ridge K-25 Site, Oak Ridge Y-12 Plant; and two sister sites: Portsmouth Gaseous Diffusion Plant in Portsmouth, Ohio, and Paducah Gaseous Diffusion Plant in Paducah, Kentucky. The role of the DMCs is to receive, store, retrieve, and properly dispose of records. In an effort to make the DMCs run more efficiently and to more proactively manage the records' life cycles from cradle to grave, ER has decided to investigate ways in which Electronic Document Management System (EDMS) technologies can be used to redefine the DMCs and their related processes. Specific goals of this study are tightening control over the ER documents, establishing and enforcing record creation and retention procedures, speeding up access to information, and increasing the accessibility of information. A working pilot of the solution is desired within the next six months. Based on a series of interviews conducted with personnel from each of the DMCs, key management, and individuals representing related projects, it is recommended that ER utilize document management, full-text retrieval, and workflow technologies to improve and automate records management for the ER program. A phased approach to solution implementation is suggested starting with the deployment of an automated storage and retrieval system at Portsmouth. This should be followed with a roll out of the system to the other DMCs, the deployment of a workflow-enabled authoring system at Portsmouth, and a subsequent roll out of this authoring system to the other sites

Oak Ridge Reservation Site Management Plan for the Environmental Restoration Program

Energy Technology Data Exchange (ETDEWEB)

1991-09-01

This site management for the Environmental Restoration (ER) Program implements the Oak Ridge Reservation (ORR) Federal Facility Agreement (FFA) (EPA 1990), also known as an Interagency Agreement (IAG), hereafter referred to as the Agreement.'' The Department of Energy (DOE), the US Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC), hereafter known as the Parties,'' entered into this Agreement for the purpose of coordinating remediation activities undertaken on the ORR to comply with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) as amended by the Superfund Amendments, the Resource Conservation and Recovery Act (RCRA), and the National Environmental Policy Act (NEPA). 7 refs., 17 figs.

75 FR 70083 - Emergency Forest Restoration Program and Emergency Conservation Program

Science.gov (United States)

2010-11-17

... Restoration Program and Emergency Conservation Program AGENCY: Farm Service Agency, USDA. ACTION: Interim rule. SUMMARY: The Farm Service Agency (FSA) is amending regulations as required by the Food, Conservation, and... as follows: PART 701--EMERGENCY CONSERVATION PROGRAM, EMERGENCY FOREST RESTORATION PROGRAM, AND...

Daytime multispectral scanner aerial surveys of the Oak Ridge Reservation, 1992--1994: Overview of data processing and analysis by the Environmental Restoration Remote Sensing Program, Fiscal year 1995

International Nuclear Information System (INIS)

Smyre, J.L.; Hodgson, M.E.; Moll, B.W.; King, A.L.; Cheng, Yang.

1995-11-01

Environmental Restoration (ER) Remote Sensing and Special Surveys Program was in 1992 to apply the benefits of remote sensing technologies to Environmental Restoration Management (ERWM) programs at all of the five United States Department of Energy facilities operated and managed by Martin Marietta Energy Systems, Inc. (now Lockheed Martin Energy Systems)-the three Oak Ridge Reservation (ORR) facilities, the Paducah Gaseous Diffusion Plant (PGDP), the Portsmouth Gaseous Diffusion Plant (PORTS)-and adjacent off-site areas. The Remote Sensing Program includes the management of routine and special surveys at these sites, application of state-of-the-art remote sensing and geophysical technologies, and data transformation, integration, and analyses required to make the information valuable to ER. Remotely-sensed data collected of the ORR include natural color and color infrared (IR) aerial photography, 12-band multispectral scanner imagery, predawn thermal IR sensor imagery, magnetic and electromagnetic geophysical surveys, and gamma radiological data

Environmental Restoration Remedial Action Program records management plan

International Nuclear Information System (INIS)

Michael, L.E.

1991-07-01

The US Department of Energy-Richland Operations Office (DOE-RL) Environmental Restoration Field Office Management Plan [(FOMP) DOE-RL 1989] describes the plans, organization, and control systems to be used for management of the Hanford Site environmental restoration remedial action program. The FOMP, in conjunction with the Environmental Restoration Remedial Action Quality Assurance Requirements document [(QARD) DOE-RL 1991], provides all the environmental restoration remedial action program requirements governing environmental restoration work on the Hanford Site. The FOMP requires a records management plan be written. The Westinghouse Hanford Company (Westinghouse Hanford) Environmental Restoration Remedial Action (ERRA) Program Office has developed this ERRA Records Management Plan to fulfill the requirements of the FOMP. This records management plan will enable the program office to identify, control, and maintain the quality assurance, decisional, or regulatory prescribed records generated and used in support of the ERRA Program. 8 refs., 1 fig

Health and safety plan for the Environmental Restoration Program at Oak Ridge National Laboratory

International Nuclear Information System (INIS)

Clark, C. Jr.; Burman, S.N.; Cipriano, D.J. Jr.; Uziel, M.S.; Kleinhans, K.R.; Tiner, P.F.

1994-08-01

This Programmatic Health and Safety plan (PHASP) is prepared for the U.S. Department of Energy (DOE) Oak Ridge National Laboratory (ORNL) Environmental Restoration (ER) Program. This plan follows the format recommended by the U.S. Environmental Protection Agency (EPA) for remedial investigations and feasibility studies and that recommended by the EM40 Health and Safety Plan (HASP) Guidelines (DOE February 1994). This plan complies with the Occupational Safety and Health Administration (OSHA) requirements found in 29 CFR 1910.120 and EM-40 guidelines for any activities dealing with hazardous waste operations and emergency response efforts and with OSHA requirements found in 29 CFR 1926.65. The policies and procedures in this plan apply to all Environmental Restoration sites and activities including employees of Energy Systems, subcontractors, and prime contractors performing work for the DOE ORNL ER Program. The provisions of this plan are to be carried out whenever activities are initiated that could be a threat to human health or the environment. This plan implements a policy and establishes criteria for the development of procedures for day-to-day operations to prevent or minimize any adverse impact to the environment and personnel safety and health and to meet standards that define acceptable management of hazardous and radioactive materials and wastes. The plan is written to utilize past experience and best management practices to minimize hazards to human health and safety and to the environment from event such as fires, explosions, falls, mechanical hazards, or any unplanned release of hazardous or radioactive materials to air, soil, or surface water

Health and safety plan for the Environmental Restoration Program at Oak Ridge National Laboratory

Energy Technology Data Exchange (ETDEWEB)

Clark, C. Jr.; Burman, S.N.; Cipriano, D.J. Jr.; Uziel, M.S.; Kleinhans, K.R.; Tiner, P.F.

1994-08-01

This Programmatic Health and Safety plan (PHASP) is prepared for the U.S. Department of Energy (DOE) Oak Ridge National Laboratory (ORNL) Environmental Restoration (ER) Program. This plan follows the format recommended by the U.S. Environmental Protection Agency (EPA) for remedial investigations and feasibility studies and that recommended by the EM40 Health and Safety Plan (HASP) Guidelines (DOE February 1994). This plan complies with the Occupational Safety and Health Administration (OSHA) requirements found in 29 CFR 1910.120 and EM-40 guidelines for any activities dealing with hazardous waste operations and emergency response efforts and with OSHA requirements found in 29 CFR 1926.65. The policies and procedures in this plan apply to all Environmental Restoration sites and activities including employees of Energy Systems, subcontractors, and prime contractors performing work for the DOE ORNL ER Program. The provisions of this plan are to be carried out whenever activities are initiated that could be a threat to human health or the environment. This plan implements a policy and establishes criteria for the development of procedures for day-to-day operations to prevent or minimize any adverse impact to the environment and personnel safety and health and to meet standards that define acceptable management of hazardous and radioactive materials and wastes. The plan is written to utilize past experience and best management practices to minimize hazards to human health and safety and to the environment from event such as fires, explosions, falls, mechanical hazards, or any unplanned release of hazardous or radioactive materials to air, soil, or surface water.

Environmental restoration and waste management: Robotics technology development program: Robotics 5-year program plan

International Nuclear Information System (INIS)

1991-01-01

In FY 1990 Robotics Technology Development Program (RTDP) planning teams visited five DOE sites. These sites were selected by the Office of Technology Development to provide a needs basis for developing a 5-Year Plan. Visits to five DOE sites provided identification of needs for robotics technology development to support Environmental Restoration and Waste Management (ER ampersand WM) projects at those sites. Additional site visits will be conducted in the future to expand the planning basis. This volume summarizes both the results of the site visits and the needs and requirements of the priority ER ampersand WM activities at the sites, including potential needs for robotics and remote systems technology. It also discusses hazards associated with the site activities and any problems or technical uncertainties associated with dealing with the hazards in the performance of the ER ampersand WM work. Robotic or remote systems currently under development for remediation projects or waste operations are also discussed. The information in this document is organized principally by site, activity, and priority. Section 2.0, Site Needs, is based on information from the site visit reports and provides a summary which focuses on the site needs and requirements for each priority activity. Section 2.0 also records evaluations and discussions by the RTDP team following the site visit. Section 3.0, Commonality Assessment, documents similar site needs where common, or cross-cutting, robotics technology might be applied to several activities. Section 4.0 contains a summary of the site needs and requirements in tabular form. 1 tab

Oak Ridge Reservation Federal Facility Agreement for the Environmental Restoration Program. Volume 4

International Nuclear Information System (INIS)

1993-10-01

This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program that are specified in the Oak Ridge Reservation (ORR) Federal Facility Agreement (FFA) established between the U.S. Department of Energy (DOE), the U.S. Environmental protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered is July through September 1993 (fourth quarter of FY 1993). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been approved as FY 1994 commitments

Preparing for the future: Higher education meeting environmental restoration and waste management human resource needs

International Nuclear Information System (INIS)

Wohlpart, Alfred

1992-01-01

The Office of Environmental Restoration and Waste Management (ER/WM) of the U.S. Department of Energy (DOE) has as its goal the elimination of risks from hazardous waste to human health and safety and the environment or the reduction of these risks to prescribed safe levels. The achievement of this goal requires the availability of sufficient and appropriately educated scientists, engineers, and technicians. A preliminary workforce needs assessment conducted for the Office of Environmental Restoration and Waste Management in 1990 indicated that the technical workforce involved in ER/WM activities would grow by 50 to 70 percent by 1995. A more exhaustive assessment is currently underway. To ensure the availability of the necessary human resources, the Office has initiated a series of education programs. The programs designed for the college/university levels are expected to increase the number of students pursuing associate, baccalaureate, and advanced degrees in ER/WM relevant science and engineering disciplines and to initiate research and training in technical areas supportive of the ER/WM mission. The ER/WM Scholarship program provides scholarships to undergraduate students pursuing science and engineering degrees at designated two- and four-year academic institutions. Fifty-four four-year and six two-year institutions are involved. The ER/WM Fellowship program supports graduate study and research at designated academic institutions in specified science and engineering disciplines or in interdisciplinary programs, Thirty graduate students are pursuing advanced degrees in disciplines supportive of the ER/WM mission at 14 different academic institutions. Scholars and fellows are required to spend one summer at a DOE facility participating in ongoing ER/WM projects. The fellowship and scholarship programs are expected to create a pool of appropriately educated professionals ready to enter the workforce and contribute to the DOE mission. To ensure the full

Environmental Restoration (ER) Consolidated Quarterly Report_April to June 2017_ October 2017

Energy Technology Data Exchange (ETDEWEB)

Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-10-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented at Sandia National Laboratories, New Mexico (SNL/NM) during the April, May, and June 2017 quarterly reporting period. Table I-1 lists the Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM. Sections I.2.1 and I.2.2 summarize the work completed during this quarter. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities. Field activities are conducted at the three groundwater AOCs (Burn Site Groundwater [BSG AOC], Technical Area [TA]-V Groundwater [TAVG AOC], and Tijeras Arroyo Groundwater [TAG AOC]). Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) Hazardous Waste Bureau (HWB) issued a certificate of completion and the sites are in the corrective action complete (CAC) regulatory process. Currently, SWMUs 8 and 58, 68, 149, 154, and 502 are in the CAC regulatory process. Corrective action activities are deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these three sites are active mission facilities. These three active mission sites are located in TA-III.

Rab7a modulates ER stress and ER morphology.

Science.gov (United States)

Mateus, Duarte; Marini, Elettra Sara; Progida, Cinzia; Bakke, Oddmund

2018-05-01

The Endoplasmic Reticulum (ER) is a membranous organelle with diverse structural and functional domains. Peripheral ER includes interconnected tubules, and dense tubular arrays called "ER matrices" together with bona fide flat cisternae. Transitions between these states are regulated by membrane-associated proteins and cytosolic factors. Recently, the small GTPases Rab10 and Rab18 were reported to control ER shape by regulating ER dynamics and fusion. Here, we present evidence that another Rab protein, Rab7a, modulates the ER morphology by controlling the ER homeostasis and ER stress. Indeed, inhibition of Rab7a expression by siRNA or expression of the dominant negative mutant Rab7aT22 N, leads to enlargement of sheet-like ER structures and spreading towards the cell periphery. Notably, such alterations are ascribable neither to a direct modulation of the ER shaping proteins Reticulon-4b and CLIMP63, nor to interactions with Protrudin, a Rab7a-binding protein known to affect the ER organization. Conversely, depletion of Rab7a leads to basal ER stress, in turn causing ER membrane expansion. Both ER enlargement and basal ER stress are reverted in rescue experiments by Rab7a re-expression, as well as by the ER chemical chaperone tauroursodeoxycholic acid (TUDCA). Collectively, these findings reveal a new role of Rab7a in ER homeostasis, and indicate that genetic and pharmacological ER stress manipulation may restore ER morphology in Rab7a silenced cells. Copyright © 2018 Elsevier B.V. All rights reserved.

Using Informal Articles in Extensive Reading (ER Program: A Personal Experience

Directory of Open Access Journals (Sweden)

Chothibul Umam

2015-12-01

Full Text Available In this digital age, informal articles which contain some valuable informations and extensive input to develop the learners’ language proficiency are easily found on internet or other reading sources. Unfortunately most literature shows that informal articles are not widely used in extensive reading (henceforth ER program. For this reason, the paper introduces steps procedure in using informal articles as authentic material in one semester ER program for Indonesian EFL college learners. The procedure is developed on the basis of my great interest in creating innovative way in teaching ER at one of the State Institute for Islamic Studies in Indonesia. The proposed steps are expected to be an alternative pathway in teaching ER for English teachers particularly at a college-university level. Keywords: Extensive Reading, informal article.Copyright © 2015 by Al-Ta'lim All right reserved

Evaluation of microleakage occurred in class V restoration prepared with Er:YAG laser and also with high speed, restored using composite

International Nuclear Information System (INIS)

Junqueira, Angelo Maercio Finochio

2002-01-01

The microleakage is one of the great problems found in restoring dentistry. In spite of adhesive system evolution, several materials have been studied intending to minimize or to eliminate the microleakage occurred between the tooth and restorative material. The objective of this in vitro study was to evaluate and compare the marginal microleakage in class V cavities prepared by Er:YAG laser or high speed and restored with composite resin. One of the groups received the sodium bicarbonate jet while the other group have not received. Twenty teeth third extracted molars were sectioned in the sense medial-distal being obtained forty samples that were divided in four groups: Group I (G1): prepared with Er:YAG laser (2940 nm), E= 350 mJ/p, F=2 Hz, fluency of 112,5 J/cm 2 . Preparing occlusion margin slice with 250 mJ/p, F=2 Hz, fluency of 80,3 J/cm 2 . The prepared total area was irradiated with E=80 mJ/p, F=2 Hz and fluency of 25,75 J/cm 2 . Every prepared area was finally submitted to sodium bicarbonate jet. Group 2 (G2): it was employed the same parameters used on group 1, except the sodium carbonate jet application. Group 3 (G3): the cavities' prepare were executed with high speed rotation using diamond cylindrical point. The slice confection has been made with the same point with 45 degrees inclined, utilizing also the sodium carbonate jet in all prepared area. Group 4 (G4): it was executed similarly prepared to group 3, without the sodium bicarbonate jet. In all the groups the cavities were washed with water spray and drought with air jet. Dentin and enamel surfaces have been conditioned with phosphoric acid at 35%. All the samples of all groups were restored using the single bond system adhesive and composite resin Z250, kept at 37 deg C in stove during 24 hours, thermally stressed, immersed in silver nitrate solution at 50% for 24 hours while kept in darkness. The specimens were soaked in photo developing solution and exposed to fluorescent light for 6 hours

Annual report of the Environmental Restoration Monitoring and Assessment Program at Oak Ridge National Laboratory for FY 1992

International Nuclear Information System (INIS)

Clapp, R.B.

1992-09-01

This report summarizes the salient features of the annual efforts of the investigations and monitoring, conducted to support the Environmental Restoration (ER) Program at Oak Ridge National Laboratory (ORNL). The results presented can be used to develop a conceptual understanding of the key contaminants and the sources, fluxes, and processes affecting their distribution and movement. This information forms a basis for prioritizing sites and for selecting, implementing, and evaluating remedial actions. Groundwater, soils, sediments, and surface water monitoring results are described

Marginal microleakage evaluation in class V composite restorations of deciduous teeth prepared conventionally and using Er:YAG laser; Avaliacao da microinfiltracao marginal em cavidades classe V de dentes deciduos preparados com laser Er:YAG e alta rotacao

Energy Technology Data Exchange (ETDEWEB)

Pulga, Neusa Vieira Galvao

2001-07-01

The evaluation of marginal microleakage in class V restorations of deciduous teeth prepared using Er:laser and comparison to the ones observed when conventionally prepared, using two photopolimerizable materials, composite resin and glass ionomer cement, was the subject of this study. Twenty eight complete deciduous teeth were divided into four groups Group 1 (G1) prepared with high speed drill + composite resin; Group 2 (G2) prepared with high speed drill + glass ionomer cement; Group 3 (G3) prepared using Er:YAG laser (2.94 {mu}m), 300 mJ, 3 Hz, handpiece 2051, energy density 86 mJ/cm{sup 2} + composite resin; Group 4 (G4) prepared using Er:YAG laser (2.94 {mu}m), 300 mJ, 3 Hz, handpiece 2051, energy density 86 J / cm{sup 2} + glass ionomer cement. After the preparation and restoration the specimens where stored at 37 deg C for 24 hours, thermally stressed, immersed in 50% aqueous solution of silver nitrate for 24 hours while kept in the dark. The specimens were rinsed in water, soaked in photodeveloping solution and exposed to fluorescent light for 6 hours. After this process the samples were sectioned and observed by stereomicroscopy. For comparison the groups were divided into occlusive and cervical microleakage. The results were analysed under the Kruskal-Wallis test. For the occlusive microleakage the statistical significance was 5% among the groups and the average comparison showed higher microleakage for G1 (M=35.1) than for G2 (M=24.0) as well as compared to G3 (M=22.3). The other groups did not present statistical differences among them. For the cervical microleakage the Kruskal-Wallis test did not present any statistical difference. Comparing the occlusive and cervical microleakage data, for every group, using the Wilcoxon test, no statistical differences were observed. Concluding, this study showed the Er:YAG laser to be effective for class V restorations and to result in a smaller microleakage degree using the composite resin. These results indicate

Environmental Restoration Program Control Management System

International Nuclear Information System (INIS)

Duke, R.T.

1992-01-01

Environmental Restoration managers need to demonstrate that their programs are under control. Unlike most industrial programs, the public is heavily involved in Environmental Restoration activities. The public is demanding that the country prove that real progress is being made towards cleaning up the environment. A Program Control Management System can fill this need. It provides a structure for planning, work authorization, data accumulation, data analysis and change control. But it takes time to implement a control system and the public is losing its patience. This paper describes critical items essential to the quick development and implementation of a successful control system

The RESTORE program of restorative justice for sex crimes: vision, process, and outcomes.

Science.gov (United States)

Koss, Mary P

2014-06-01

The article reports empirical evaluation of RESTORE, a restorative justice (RJ) conferencing program adapted to prosecutor-referred adult misdemeanor and felony sexual assaults. RESTORE conferences included voluntary enrollment, preparation, and a face-to-face meeting where primary and secondary victims voice impacts, and responsible persons acknowledge their acts and together develop a re-dress plan that is supervised for 1 year. Process data included referral and consent rates, participant characteristics, observational ratings of conferences compared with program design, services delivered, and safety monitoring. Outcome evaluation used 22 cases to assess (a) pre-post reasons for choosing RESTORE, (b) preparation and conference experiences, (c) overall program and justice satisfaction, and (d) completion rates. This is the first peer-reviewed quantitative evaluation of RJ conferencing for adult sexual assault. Although the data have limitations, the results support cautious optimism regarding feasibility, safety, and satisfactory outcomes. They help envision how conferencing could expand and individualize justice options for sexual assault.

Completion Report for Wells ER-20-8 and ER-20-8#2 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Management

2011-02-28

Wells ER-20-8 and ER-20-8#2 were drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The holes were drilled in July and August 2009, as part of the Pahute Mesa Phase II drilling program. The primary purpose of these wells was to provide detailed hydrogeologic information in the Tertiary volcanic section that will help address uncertainties within the Pahute Mesa–Oasis Valley hydrostratigraphic framework model. They may also be used as long-term monitoring wells.

INDICTORS OF RESTORATION OF PROGRAM FACILITY OF MECHATRONICS SYSTEM

Directory of Open Access Journals (Sweden)

V. Frolov

2009-01-01

Full Text Available The determination of reliability indictors of program facilities of mechatronic systems are offered. The defaillance modes of program facilities are represent. A short review of model reliability of program facility is presented. The indictors of restoration, their mathematical determinations and application for the characteristics of program facility restoration are offered.

Quality Assurance Program Plan for the Environmental Restoration Program

International Nuclear Information System (INIS)

1992-01-01

The United States Department of Energy (USDOE) has initiated the Environmental Restoration Program (ERP) in an effort to manage, control and remediate existing hazardous, toxic and radioactive wastes generated at the Portsmouth Gaseous Diffusion Plant (PORTS). This ERP Quality Assurance Program Plan (QAPP) is responsive to the PORTS ESH Division QAPP and the ES Environmental Restoration Division (ERD) QAPP. This QAPP establishes the policies, requirements and responsibilities by which an appropriate level of QA shall be implemented within the PORTS-ERP. All PORTS-ERP activities shall be conducted in accordance with the requirements of this document and/or of a project level document which is derivative of this document

75 FR 6354 - NOAA Great Lakes Habitat Restoration Program Project Grants under the Great Lakes Restoration...

Science.gov (United States)

2010-02-09

...-04] RIN 0648-ZC10 NOAA Great Lakes Habitat Restoration Program Project Grants under the Great Lakes... Atmospheric Administration (NOAA), Department of Commerce. ACTION: Notice of funding availability; Date... on January 19, 2010. That notice announced the NOAA Great Lakes Habitat Restoration Program Project...

Basic research for environmental restoration

International Nuclear Information System (INIS)

1990-12-01

The Department of Energy (DOE) is in the midst of a major environmental restoration effort to reduce the health and environmental risks resulting from past waste management and disposal practices at DOE sites. This report describes research needs in environmental restoration and complements a previously published document, DOE/ER-0419, Evaluation of Mid-to-Long Term Basic Research for Environmental Restoration. Basic research needs have been grouped into five major categories patterned after those identified in DOE/ER-0419: (1) environmental transport and transformations; (2) advanced sampling, characterization, and monitoring methods; (3) new remediation technologies; (4) performance assessment; and (5) health and environmental effects. In addition to basic research, this document deals with education and training needs for environmental restoration. 2 figs., 6 tabs

Basic research for environmental restoration

Energy Technology Data Exchange (ETDEWEB)

1990-12-01

The Department of Energy (DOE) is in the midst of a major environmental restoration effort to reduce the health and environmental risks resulting from past waste management and disposal practices at DOE sites. This report describes research needs in environmental restoration and complements a previously published document, DOE/ER-0419, Evaluation of Mid-to-Long Term Basic Research for Environmental Restoration. Basic research needs have been grouped into five major categories patterned after those identified in DOE/ER-0419: (1) environmental transport and transformations; (2) advanced sampling, characterization, and monitoring methods; (3) new remediation technologies; (4) performance assessment; and (5) health and environmental effects. In addition to basic research, this document deals with education and training needs for environmental restoration. 2 figs., 6 tabs.

Environmental Restoration Program pollution prevention checklist guide for the surveillance and maintenance project phase

International Nuclear Information System (INIS)

1993-09-01

DOE Order 5820.2 mandates that a surveillance and maintenance program be established in all shut-down facilities to ensure adequate containment of contamination, provide physical safety and security, and reduce potential public and environmental hazards. A key consideration in this process is the prevention of any waste to be generated from these activities. The purpose of this checklist guide is to assist the user with incorporating pollution prevention/waste minimization (PP/WM) in all Surveillance and Maintenance (S ampersand M) phase projects of the Environmental Restoration (ER) Program. This guide will help users document their PP/WM activities for technology transfer and reporting requirements. Automated computer screens will be created from the checklist data to assist users with implementing and evaluating waste reduction. Users can then establish numerical performance measures to measure progress in planning, training, self-assessments, field implementation, documentation, and technology transfer. Cost savings result as users train and assess themselves and perform preliminary waste assessments

Technology needs assessment for DOE environmental restoration programs

International Nuclear Information System (INIS)

Duray, J.R.; Carlson, T.J.; Carpenter, C.E.; Cummins, L.E.; Daub, G.J.

1992-01-01

The 'Technology Needs Assessment Final Report' describes current and planned environmental restoration activity, identifies technologies intended to be used or under consideration, and ranks technology deficiencies in the U.S. Department of Energy's environmental restoration program. Included in the ranking are treatment technologies, characterization technologies, and non-technology issues that affect environmental restoration. Data used for the assessment was gathered during interviews in the spring of 1991 with DOE site personnel responsible for the environmental restoration work. (author)

Marginal microleakage in vitro study on class V cavities prepared with Er:YAG laser and etched with acid or etched with Er:YAG laser and acid; Estudo in vitro da microinfiltracao marginal em cavidades classe V preparadas com laser de Er:YAG e condicionadas com acido ou com laser de Er:YAG e acido

Energy Technology Data Exchange (ETDEWEB)

Tavares, Henrique Dutra Simoes

2001-07-01

Microleakage at the interface between the teeth and the restorative materials remains a problem with composite resin restorations. Microleakage at the gingival margins of class V cavities restorations still challenge as they are usually placed in dentin and/or cementum. Previous studies have shown that the cavity preparation with Er:YAG laser is possible. It has been reported that Er:YAG laser has ability to create irregular surface providing micromechanical retention for adhesive dental restorative materials and to improve marginal sealing. The purpose of this in vitro study was to evaluate the marginal microleakage on class V cavities prepared with Er:YAG laser and etched with acid or with Er:YAG laser and acid, in compared to those prepared and etched conventionally. Thirty human molars were divided into three groups, namely: group I - prepared with Er:YAG laser (KaVo KEY Laser II - Germany) and etched with 37% phosphoric acid; group II - prepared with Er:YAG laser and etched with Er:YAG laser and 37% phosphoric acid; group III (control group) - prepared with high speed drill and etched with 37% phosphoric acid. All cavities were treated with same adhesive system (Single Bond - 3M) and restored with the composite resin (Z100 - 3M), according to the manufacturer's instructions. The specimens were stored at 37 deg C in water for 24 hours, polished with Sof-Lex discs (3M), thermally stressed, sealed with a nail polish coating except for the area of the restoration and 1 mm around it, and immersed in a 50% aqueous solution of silver nitrate for 24 hours. After that, the specimens were rinsed in water, soaked in a photodeveloping solution and exposed to a fluorescent light for 8 hours. The teeth were embedded in an autopolymerizing resin and sectioned longitudinally using a diamond saw microtome under running water. The sections were photographed. The microleakage at the occlusal cavity and at the gingival margins of each specimen was evaluated with scores (0-3) by

Marginal microleakage in vitro study on class V cavities prepared with Er:YAG laser and etched with acid or etched with Er:YAG laser and acid; Estudo in vitro da microinfiltracao marginal em cavidades classe V preparadas com laser de Er:YAG e condicionadas com acido ou com laser de Er:YAG e acido

Energy Technology Data Exchange (ETDEWEB)

Tavares, Henrique Dutra Simoes

2001-07-01

Microleakage at the interface between the teeth and the restorative materials remains a problem with composite resin restorations. Microleakage at the gingival margins of class V cavities restorations still challenge as they are usually placed in dentin and/or cementum. Previous studies have shown that the cavity preparation with Er:YAG laser is possible. It has been reported that Er:YAG laser has ability to create irregular surface providing micromechanical retention for adhesive dental restorative materials and to improve marginal sealing. The purpose of this in vitro study was to evaluate the marginal microleakage on class V cavities prepared with Er:YAG laser and etched with acid or with Er:YAG laser and acid, in compared to those prepared and etched conventionally. Thirty human molars were divided into three groups, namely: group I - prepared with Er:YAG laser (KaVo KEY Laser II - Germany) and etched with 37% phosphoric acid; group II - prepared with Er:YAG laser and etched with Er:YAG laser and 37% phosphoric acid; group III (control group) - prepared with high speed drill and etched with 37% phosphoric acid. All cavities were treated with same adhesive system (Single Bond - 3M) and restored with the composite resin (Z100 - 3M), according to the manufacturer's instructions. The specimens were stored at 37 deg C in water for 24 hours, polished with Sof-Lex discs (3M), thermally stressed, sealed with a nail polish coating except for the area of the restoration and 1 mm around it, and immersed in a 50% aqueous solution of silver nitrate for 24 hours. After that, the specimens were rinsed in water, soaked in a photodeveloping solution and exposed to a fluorescent light for 8 hours. The teeth were embedded in an autopolymerizing resin and sectioned longitudinally using a diamond saw microtome under running water. The sections were photographed. The microleakage at the occlusal cavity and at the gingival margins of each specimen was evaluated with scores (0

Completion report for Well Cluster ER-20-6

International Nuclear Information System (INIS)

1998-02-01

The Well Cluster ER-20-6 drilling and completion project was conducted during February, March, and April of 1996 in support of the Nevada Environmental Restoration Project at the Nevada Test Site (NTS), Nye County, Nevada. This project is part of the DOE's Underground Test Area (UGTA) subproject at the NTS. The primary UGTA tasks include collecting geological, geophysical, and hydrological data from new and existing wells to define groundwater quality as well as pathways and rates of groundwater migration at the NTS. A program of drilling wells near the sites of selected underground nuclear tests (near-field drilling) was implemented as part of the UGTA subproject to obtain site-specific data on the nature and extent of migration of radionuclides produced by an underground nuclear explosion. The ER-20-6 near-field drilling project was originally planned to be very similar to that recently conducted at Well Cluster ER-20-5, which was designed to obtain data on the existing hydrologic regime near the site of an underground nuclear explosion (IT, 1995; IT, 1996a). However, after further consideration of the goals of the near-field drilling program and the characteristics of the BULLION site, the TWG recommended that the ER-20-6 project be redesigned to accommodate a forced-gradient experiment. This proposed experiment is expected to yield more realistic estimates of transport parameters than can be deduced from sampling and testing natural groundwater flow systems

Completion report for Well Cluster ER-20-6

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-02-01

The Well Cluster ER-20-6 drilling and completion project was conducted during February, March, and April of 1996 in support of the Nevada Environmental Restoration Project at the Nevada Test Site (NTS), Nye County, Nevada. This project is part of the DOE`s Underground Test Area (UGTA) subproject at the NTS. The primary UGTA tasks include collecting geological, geophysical, and hydrological data from new and existing wells to define groundwater quality as well as pathways and rates of groundwater migration at the NTS. A program of drilling wells near the sites of selected underground nuclear tests (near-field drilling) was implemented as part of the UGTA subproject to obtain site-specific data on the nature and extent of migration of radionuclides produced by an underground nuclear explosion. The ER-20-6 near-field drilling project was originally planned to be very similar to that recently conducted at Well Cluster ER-20-5, which was designed to obtain data on the existing hydrologic regime near the site of an underground nuclear explosion (IT, 1995; IT, 1996a). However, after further consideration of the goals of the near-field drilling program and the characteristics of the BULLION site, the TWG recommended that the ER-20-6 project be redesigned to accommodate a forced-gradient experiment. This proposed experiment is expected to yield more realistic estimates of transport parameters than can be deduced from sampling and testing natural groundwater flow systems.

Integrated Safety Management System Phase 1 and 2 Verification for the Environmental Restoration Contractor Volumes 1 and 2

Energy Technology Data Exchange (ETDEWEB)

CARTER, R.P.

2000-04-04

DOE Policy 450.4 mandates that safety be integrated into all aspects of the management and operations of its facilities. The goal of an institutionalized Integrated Safety Management System (ISMS) is to have a single integrated system that includes Environment, Safety, and Health requirements in the work planning and execution processes to ensure the protection of the worker, public, environment, and the federal property over the life cycle of the Environmental Restoration (ER) Project. The purpose of this Environmental Restoration Contractor (ERC) ISMS Phase MI Verification was to determine whether ISMS programs and processes were institutionalized within the ER Project, whether these programs and processes were implemented, and whether the system had promoted the development of a safety conscious work culture.

Second annual report of the Environmental Restoration Monitoring and Assessment Program at Oak Ridge National Laboratory

International Nuclear Information System (INIS)

Clapp, R.B.; Watts, J.A.

1993-09-01

This report summarizes the salient features of the annual efforts of environmental monitoring and field investigations conducted to support the Environmental Restoration (ER) Program at the Oak Ridge National Laboratory (ORNL). This report focuses on the watershed scale, striving to provide an ORNL site-wide perspective on types, distribution, and transport of contamination. Results are used to enhance the conceptual understanding of the key contaminants and the sources, fluxes, and processes affecting their distribution and movement. This report summarizes the efforts of the Waste Area Grouping (WAG) 2 and Site Investigations (SI) program. WAG 2 is the lower portion of the White Oak Creek (WOC) system which drains the major contaminated sites at ORNL and discharges to the Clinch River where public access is allowed. The remedial investigation for WAG 2 includes a long-term multimedia environmental monitoring effort that takes advantage of WAG 2's role as an integrator and conduit of contaminants from the ORNL site. This report also includes information from other site-specific remedial investigations and feasibility studies (RI/FS) for contaminated sites at ORNL and data from other ongoing monitoring programs conducted by other organizations [e.g., the National Pollutant Discharge Elimination System (NPDES) compliance monitoring conducted by the Environmental Surveillance and Protection Section]. This information is included to provide an integrated basis to support ER decision making. This report summarizes information gathered through early 1993. Annual data, such as annual discharges of contaminants, are reported for calendar year 1992

ER Consolidated Quarterly Report October 2014

Energy Technology Data Exchange (ETDEWEB)

Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2014-10-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective actions and related Long- Term Stewardship (LTS) activities being implemented by Sandia National Laboratories, New Mexico (SNL/NM) ER for the April, May, and June 2014 quarterly reporting period. Section 2.0 provides the status of ER Operations activities including closure activities for the Mixed Waste Landfill (MWL), project management and site closure, and hydrogeologic characterizations. Section 3.0 provides the status of LTS activities that relate to the Chemical Waste Landfill (CWL) and the associated Corrective Action Management Unit (CAMU). Section 4.0 provides the references noted in Section I of this report.

Environmental restoration risk-based prioritization work package planning and risk ranking methodology. Revision 2

International Nuclear Information System (INIS)

Dail, J.L.; Nanstad, L.D.; White, R.K.

1995-06-01

This document presents the risk-based prioritization methodology developed to evaluate and rank Environmental Restoration (ER) work packages at the five US Department of Energy, Oak Ridge Field Office (DOE-ORO) sites [i.e., Oak Ridge K-25 Site (K-25), Portsmouth Gaseous Diffusion Plant (PORTS), Paducah Gaseous Diffusion Plant (PGDP), Oak Ridge National Laboratory (ORNL), and the Oak Ridge Y-12 Plant (Y-12)], the ER Off-site Program, and Central ER. This prioritization methodology was developed to support the increased rigor and formality of work planning in the overall conduct of operations within the DOE-ORO ER Program. Prioritization is conducted as an integral component of the fiscal ER funding cycle to establish program budget priorities. The purpose of the ER risk-based prioritization methodology is to provide ER management with the tools and processes needed to evaluate, compare, prioritize, and justify fiscal budget decisions for a diverse set of remedial action, decontamination and decommissioning, and waste management activities. The methodology provides the ER Program with a framework for (1) organizing information about identified DOE-ORO environmental problems, (2) generating qualitative assessments of the long- and short-term risks posed by DOE-ORO environmental problems, and (3) evaluating the benefits associated with candidate work packages designed to reduce those risks. Prioritization is conducted to rank ER work packages on the basis of the overall value (e.g., risk reduction, stakeholder confidence) each package provides to the ER Program. Application of the methodology yields individual work package ''scores'' and rankings that are used to develop fiscal budget requests. This document presents the technical basis for the decision support tools and process

Marginal microleakage in vitro study on class V cavities prepared with Er:YAG laser and etched with acid or etched with Er:YAG laser and acid

International Nuclear Information System (INIS)

Tavares, Henrique Dutra Simoes

2001-01-01

Microleakage at the interface between the teeth and the restorative materials remains a problem with composite resin restorations. Microleakage at the gingival margins of class V cavities restorations still challenge as they are usually placed in dentin and/or cementum. Previous studies have shown that the cavity preparation with Er:YAG laser is possible. It has been reported that Er:YAG laser has ability to create irregular surface providing micromechanical retention for adhesive dental restorative materials and to improve marginal sealing. The purpose of this in vitro study was to evaluate the marginal microleakage on class V cavities prepared with Er:YAG laser and etched with acid or with Er:YAG laser and acid, in compared to those prepared and etched conventionally. Thirty human molars were divided into three groups, namely: group I - prepared with Er:YAG laser (KaVo KEY Laser II - Germany) and etched with 37% phosphoric acid; group II - prepared with Er:YAG laser and etched with Er:YAG laser and 37% phosphoric acid; group III (control group) - prepared with high speed drill and etched with 37% phosphoric acid. All cavities were treated with same adhesive system (Single Bond - 3M) and restored with the composite resin (Z100 - 3M), according to the manufacturer's instructions. The specimens were stored at 37 deg C in water for 24 hours, polished with Sof-Lex discs (3M), thermally stressed, sealed with a nail polish coating except for the area of the restoration and 1 mm around it, and immersed in a 50% aqueous solution of silver nitrate for 24 hours. After that, the specimens were rinsed in water, soaked in a photodeveloping solution and exposed to a fluorescent light for 8 hours. The teeth were embedded in an autopolymerizing resin and sectioned longitudinally using a diamond saw microtome under running water. The sections were photographed. The microleakage at the occlusal cavity and at the gingival margins of each specimen was evaluated with scores (0-3) by

78 FR 58526 - Strategic Environmental Research and Development Program, Scientific Advisory Board; Notice of...

Science.gov (United States)

2013-09-24

... Liquid Propellant System for Orbital/ Air Warfare Center, Sub-Orbital Applications (FY14 New Start...). 2:30 p.m Break 2:45 p.m 14 ER03-035 (ER-2431): Quantitative Dr. Todd Bridges, USACE- Thermodynamic... Restoration, Program Manager. 3:40 p.m 14 ER04-001 (ER-2135): Application of Biofilm Dr. Birthe Kjellerup...

ER Consolidated Qtrly Rpt_April-June 2016_October 2016

Energy Technology Data Exchange (ETDEWEB)

Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-10-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented by Sandia National Laboratories, New Mexico (SNL/NM) for the April, May, and June 2016 quarterly reporting period.

Technology needs for environmental restoration remedial action

Energy Technology Data Exchange (ETDEWEB)

Watson, J.S.

1992-11-01

This report summarizes the current view of the most important technology needs for the US Department of Energy (DOE) facilities operated by Martin Marietta Energy Systems, Inc. These facilities are the Oak Ridge National Laboratory, the Oak Ridge K-25 Site, the Oak Ridge Y-12 Plant, the Paducah Gaseous Diffusion Plant, and the Portsmouth Gaseous Diffusion Plant. The sources of information used in this assessment were a survey of selected representatives of the Environmental Restoration (ER) programs at each facility, results from a questionnaire distributed by Geotech CWM, Inc., for DOE, and associated discussions with individuals from each facility. This is not a final assessment, but a brief look at an ongoing assessment; the needs will change as the plans for restoration change and, it is hoped, as some technical problems are solved through successful development programs.

Technology needs for environmental restoration remedial action

International Nuclear Information System (INIS)

Watson, J.S.

1992-11-01

This report summarizes the current view of the most important technology needs for the US Department of Energy (DOE) facilities operated by Martin Marietta Energy Systems, Inc. These facilities are the Oak Ridge National Laboratory, the Oak Ridge K-25 Site, the Oak Ridge Y-12 Plant, the Paducah Gaseous Diffusion Plant, and the Portsmouth Gaseous Diffusion Plant. The sources of information used in this assessment were a survey of selected representatives of the Environmental Restoration (ER) programs at each facility, results from a questionnaire distributed by Geotech CWM, Inc., for DOE, and associated discussions with individuals from each facility. This is not a final assessment, but a brief look at an ongoing assessment; the needs will change as the plans for restoration change and, it is hoped, as some technical problems are solved through successful development programs

Habitat Restoration as a Key Conservation Lever for Woodland Caribou: A review of restoration programs and key learnings from Alberta

Directory of Open Access Journals (Sweden)

Paula Bentham

2015-12-01

Full Text Available The Recovery Strategy for the Woodland Caribou (Rangifer tarandus caribou, Boreal Population in Canada (EC, 2012, identifies coordinated actions to reclaim woodland caribou habitat as a key step to meeting current and future caribou population objectives. Actions include restoring industrial landscape features such as roads, seismic lines, pipelines, cut-lines, and cleared areas in an effort to reduce landscape fragmentation and the changes in caribou population dynamics associated with changing predator-prey dynamics in highly fragmented landscapes. Reliance on habitat restoration as a recovery action within the federal recovery strategy is high, considering all Alberta populations have less than 65% undisturbed habitat, which is identified in the recovery strategy as a threshold providing a 60% chance that a local population will be self-sustaining. Alberta’s Provincial Woodland Caribou Policy also identifies habitat restoration as a critical component of long-term caribou habitat management. We review and discuss the history of caribou habitat restoration programs in Alberta and present outcomes and highlights of a caribou habitat restoration workshop attended by over 80 representatives from oil and gas, forestry, provincial and federal regulators, academia and consulting who have worked on restoration programs. Restoration initiatives in Alberta began in 2001 and have generally focused on construction methods, revegetation treatments, access control programs, and limiting plant species favourable to alternate prey. Specific treatments include tree planting initiatives, coarse woody debris management along linear features, and efforts for multi-company and multi-stakeholder coordinated habitat restoration on caribou range. Lessons learned from these programs have been incorporated into large scale habitat restoration projects near Grande Prairie, Cold Lake, and Fort McMurray. A key outcome of our review is the opportunity to provide a

Columbia Estuary Ecosystem Restoration Program: Restoration Design Challenges for Topographic Mounds, Channel Outlets, and Reed Canarygrass

Energy Technology Data Exchange (ETDEWEB)

Diefenderfer, Heida L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Borde, Amy B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sinks, Ian A. [Columbia Land Trust, Vancouver, WA (United States); Cullinan, Valerie I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zimmerman, Shon A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2016-08-31

The purpose of this study was to provide science-based information to practitioners and managers of restoration projects in the Columbia Estuary Ecosystem Restoration Program (CEERP) regarding aspects of restoration techniques that currently pose known challenges and uncertainties. The CEERP is a program of the Bonneville Power Administration (BPA) and the U.S. Army Corps of Engineers (Corps), Portland District, in collaboration with the National Marine Fisheries Service and five estuary sponsors implementing restoration. The estuary sponsors are Columbia Land Trust, Columbia River Estuary Study Taskforce, Cowlitz Tribe, Lower Columbia Estuary Partnership, and Washington Department of Fish and Wildlife. The scope of the research conducted during federal fiscal year 2015 included three aspects of hydrologic reconnection that were selected based on available scientific information and feedback from restoration practitioners during project reviews: the design of mounds (also called hummocks, peninsulas, or berms); the control of reed canarygrass (Phalaris arundinaceae); and aspects of channel network design related to habitat connectivity for juvenile salmonids.

Environmental Restoration Program pollution prevention checklist guide for the feasibility study project phase

International Nuclear Information System (INIS)

1993-09-01

Feasibility studies (FS) determine what remedial alternatives are presented to regulators for site cleanup. A key consideration in this process is the waste to be generated. Minimizing the volume and toxicity of this waste will ultimately contribute to the selection of the best remedial option. The purpose of this checklist guide is to assist the user in incorporating pollution prevention/waste minimization (PP/WM) in all FS phase projects of the Environmental Restoration (ER) Program. This guide will help users document PP/WM activities for technology transfer and reporting requirements. Automated computer screens will be created from the checklist data to assist users with implementing and evaluating waste reduction. Users can then establish numerical performance measures to measure progress in planning, training, self-assessments, field implementation, documentation, and technology transfer. Cost savings result as users train and assess themselves and perform preliminary waste assessments

Coronavirus infection, ER stress and Apoptosis

Directory of Open Access Journals (Sweden)

TO SING eFUNG

2014-06-01

Full Text Available The replication of coronavirus, a family of important animal and human pathogens, is closely associated with the cellular membrane compartments, especially the endoplasmic reticulum (ER. Coronavirus infection of cultured cells was previously shown to cause ER stress and induce the unfolded protein response (UPR, a process that aims to restore the ER homeostasis by global translation shutdown and increasing the ER folding capacity. However under prolonged ER stress, UPR can also induce apoptotic cell death. Accumulating evidence from recent studies has shown that induction of ER stress and UPR may constitute a major aspect of coronavirus-host interaction. Activation of the three branches of UPR modulates a wide variety of signaling pathways, such as mitogen-activated protein (MAP kinases activation, autophagy, apoptosis and innate immune response. ER stress and UPR activation may therefore contribute significantly to the viral replication and pathogenesis during coronavirus infection. In this review, we summarize current knowledge on coronavirus-induced ER stress and UPR activation, with emphasis on their cross-talking to apoptotic signaling.

Oak Ridge Reservation Federal Facility Agreement. Quarterly report for the Environmental Restoration Program. Volume 4, July 1995--September 1995

International Nuclear Information System (INIS)

1995-10-01

This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program that are specified in the Oak Ridge Reservation Federal Facility Agreement (FFA) established between the U.S. Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered herein is July through September 1995 (fourth quarter of FY 1995). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been approved as FY 1995 commitments

Site descriptions of environmental restoration units at the Oak Ridge K-25 Site, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Goddard, P.L.; Legeay, A.J.; Pesce, D.S.; Stanley, A.M.

1995-11-01

This report, Site Descriptions of Environmental Restoration Units at the Oak Ridge K-25 Site, Oak Ridge, Tennessee, is being prepared to assimilate information on sites included in the Environmental Restoration (ER) Program of the K-25 Site, one of three major installations on the Oak Ridge Reservation (ORR) built during World War III as part of the Manhattan Project. The information included in this report will be used to establish program priorities so that resources allotted to the K-25 ER Program can be best used to decrease any risk to humans or the environment, and to determine the sequence in which any remedial activities should be conducted. This document will be updated periodically in both paper and Internet versions. Units within this report are described in individual data sheets arranged alphanumerically. Each data sheet includes entries on project status, unit location, dimensions and capacity, dates operated, present function, lifecycle operation, waste characteristics, site status, media of concern, comments, and references. Each data sheet is accompanied by a photograph of the unit, and each unit is located on one of 13 area maps. These areas, along with the sub-area, unit, and sub-unit breakdowns within them, are outlined in Appendix A. Appendix B is a summary of information on remote aerial sensing and its applicability to the ER program

Site descriptions of environmental restoration units at the Oak Ridge K-25 Site, Oak Ridge, Tennessee

Energy Technology Data Exchange (ETDEWEB)

Goddard, P.L.; Legeay, A.J.; Pesce, D.S.; Stanley, A.M.

1995-11-01

This report, Site Descriptions of Environmental Restoration Units at the Oak Ridge K-25 Site, Oak Ridge, Tennessee, is being prepared to assimilate information on sites included in the Environmental Restoration (ER) Program of the K-25 Site, one of three major installations on the Oak Ridge Reservation (ORR) built during World War III as part of the Manhattan Project. The information included in this report will be used to establish program priorities so that resources allotted to the K-25 ER Program can be best used to decrease any risk to humans or the environment, and to determine the sequence in which any remedial activities should be conducted. This document will be updated periodically in both paper and Internet versions. Units within this report are described in individual data sheets arranged alphanumerically. Each data sheet includes entries on project status, unit location, dimensions and capacity, dates operated, present function, lifecycle operation, waste characteristics, site status, media of concern, comments, and references. Each data sheet is accompanied by a photograph of the unit, and each unit is located on one of 13 area maps. These areas, along with the sub-area, unit, and sub-unit breakdowns within them, are outlined in Appendix A. Appendix B is a summary of information on remote aerial sensing and its applicability to the ER program.

Analysis of well ER-18-2 testing, Western Pahute Mesa - Oasis Valley FY 2000 testing program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-18-2 during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-18-2 Data Report for Development and Hydraulic Testing.

Analysis of Well ER-EC-7 Testing, Western Pahute Mesa - Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-7 during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program was documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-7 Data Report for Development and Hydraulic Testing.

Analysis of Well ER-EC-8 testing, Western Pahute Mesa-Oasis Valley FY 2000 testing program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-8 during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa-Oasis Valley, Well ER-EC-8 Data Report for development and Hydraulic Testing.

Analysis of Well ER-EC-4 Testing, Western Pahute Mesa-Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-4 during the Western Pahute Mesa-Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-4 Data Report for Development and Hydraulic Testing.

Analysis of Well ER-EC-5 Testing, Western Pahute Mesa-Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-5 during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-5 Data Report for Development and Hydraulic Testing.

Analysis of Well ER-EC-6 Testing, Western Pahute Mesa - Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-6 during the Western Pahute Mesa-Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa-Oasis Valley, Well ER-EC-6 Data Report for Development and Hydraulic Testing.

Analysis of Well ER-EC-1 Testing, Western Pahute Mesa-Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-1 during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-1 Data Report for Development and Hydraulic Testing.

Richland Environmental Restoration Project Baseline Multi Year Work Plan Volume 1 Richland Environmental Restoration Project Plan

International Nuclear Information System (INIS)

Wintczak, T.M.

2001-01-01

The purpose of this project specification is to provide an overall scoping and document for the Environmental Restoration project, and to provide a link between the overall Hanford Site scope and the ER project. The purpose of this project specification is to provide an overall scoping document for the ER Project, and to provide a link between the overall Hanford Site scope and the ER Project. Additionally, this specification provides an integrated and consolidated source of information for the Richland ER Project. It identifies the ER Project vision, mission, and goals, as well as the operational history of the Hanford Site, along with environmental setting and hazards. This ER Project Specification is part of the overall ER Project baseline

Strategic plan for Hanford Site Environmental Restoration Information Management

International Nuclear Information System (INIS)

Cowley, P.J.; Beck, J.E.; Gephart, R.E.

1994-06-01

This strategic plan addresses information management for the Environmental Restoration (ER) Program at the Hanford Site. This Program leads the cleanup of the Hanford Site's soil, groundwater, buried waste, and the decontamination and decommissioning of facilities. The vision that drives this strategic plan is to ensure that quality information is available to the people who need it, when they need it, at a convenient location, in a usable form, and at an acceptable cost. Although investments are being made in managing the vast amounts of information, which include data, records and documents associated with the Hanford Site's production history and new cleanup mission, it is widely recognized that efforts to date have not accomplished the vision. Effective information management involves more than the compilation of massive amounts of electronic and non-electronic information. It also involves integrating information management into business processes that support user's needs and decisionmaking. Only then can information management complement and enable environmental restoration priorities and practices, help identify environmental restoration requirements, and enable communication within the Environmental Restoration Program and between the Program and its stakeholders. Successfully accomplishing the Hanford Site mission requires an integrated approach to information management that crosses organizational boundaries, streamlines existing systems, and builds new systems that support the needs of the future. This plan outlines that approach

Environmental Restoration Project - Systems Engineering Management Plan

International Nuclear Information System (INIS)

Anderson, T.D.

1998-06-01

This Environmental Restoration (ER) Project Systems Engineering Management Plan (SEMP) describes relevant Environmental Restoration Contractor (ERC) management processes and shows how they implement systems engineering. The objective of this SEMP is to explain and demonstrate how systems engineering is being approached and implemented in the ER Project. The application of systems engineering appropriate to the general nature and scope of the project is summarized in Section 2.0. The basic ER Project management approach is described in Section 3.0. The interrelation and integration of project practices and systems engineering are outlined in Section 4.0. Integration with sitewide systems engineering under the Project Hanford Management Contract is described in Section 5.0

Environmental Restoration and Waste Management Site-Specific Plan for Fiscal Year 1993

International Nuclear Information System (INIS)

1993-03-01

The Idaho National Engineering Laboratory (INEL) is a US Department of Energy (DOE) multiprogram laboratory whose primary mission has been to research nuclear technologies. Working with these technologies and conducting other types of research generates waste, including radioactive and/or hazardous wastes. While most of the waste treatment, storage, and disposal practices have been effective, some practices have led to the release of contaminants to the environment. As a result, DOE has developed (1) an Environmental Restoration (ER) Program to identify and, where necessary, cleanup releases from inactive waste sites and (2) a Waste Management (WM) Program to safely treat, store, and dispose of DOE wastes generated from current and future activities in an environmentally sound manner. This document describes the plans for FY 1993 for the INEL's ER and WM programs as managed by DOE's Idaho Field Office (DOE-ID)

Environmental Restoration and Waste Management Site-Specific Plan for Fiscal Year 1993

Energy Technology Data Exchange (ETDEWEB)

1993-03-01

The Idaho National Engineering Laboratory (INEL) is a US Department of Energy (DOE) multiprogram laboratory whose primary mission has been to research nuclear technologies. Working with these technologies and conducting other types of research generates waste, including radioactive and/or hazardous wastes. While most of the waste treatment, storage, and disposal practices have been effective, some practices have led to the release of contaminants to the environment. As a result, DOE has developed (1) an Environmental Restoration (ER) Program to identify and, where necessary, cleanup releases from inactive waste sites and (2) a Waste Management (WM) Program to safely treat, store, and dispose of DOE wastes generated from current and future activities in an environmentally sound manner. This document describes the plans for FY 1993 for the INEL`s ER and WM programs as managed by DOE`s Idaho Field Office (DOE-ID).

Oak Ridge Reservation Federal Facility Agreement quarterly report for the Environmental Restoration Program, Volume 1, October--December 1992

International Nuclear Information System (INIS)

1993-01-01

This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program which are specified in the Oak Ridge Reservation (ORR) Federal Facility Agreement (FFA) established between the US Department of Energy (DOE), the US Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered is October through December 1992(first quarter of FY 1993). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been formally approved as FY 1993 commitments. This first section is followed by: significant accomplishments; technical status at Y-12 operable units, Oak Ridge National Laboratory, Oak Ridge K-25 site, Clinch River, Oak Ridge Associated Universities, and technical oversight and technical programs; and response action contractor assignments

Case Study Application of the Biodiversity Security Index to Ranking Feasibility Studies for Ecosystem Restoration Projects of the U.S. Army Corps of Engineers

Science.gov (United States)

2016-04-01

ER D C/ EL C R- 16 -1 Ecosystem Management and Restoration Research Program Case Study Application of the Biodiversity Security Index... Biodiversity Security Index to Ranking Feasibility Studies for Ecosystem Restoration Projects of the U.S. Army Corps of Engineers Richard A. Cole... Biodiversity Security Index (BSI) was applied to 23 project sites ranked for restoration feasibility study annual funding by the U. S. Army Corps of

Central and peripheral effects of chronic food restriction and weight restoration in the rat.

Science.gov (United States)

Kinzig, Kimberly P; Hargrave, Sara L; Tao, Erin E

2009-02-01

Previous studies have demonstrated that some endocrine consequences of long-term caloric restriction persist after weight restoration in human subjects. Here we evaluate effects of chronic food restriction in rats that were restricted to 70% of control kcal for 4 wk and subsequently weight restored. Measures were taken from rats at 80% (chronically restricted; CR), 90% (partially weight restored; PR), 100% (fully weight restored; FR), and after 4 wk at 100% body weight of controls (extended weight restored; ER). Plasma insulin and leptin were decreased, and ghrelin was increased in CR compared with controls. Leptin and ghrelin normalized with weight restoration at PR, FR, and ER; however, baseline insulin was not normalized until the ER state. Hypothalamic mRNA expression levels for proopiomelanocortin (POMC), agouti-related protein (AgRP), and neuropeptide Y (NPY) revealed significantly less POMC mRNA expression in CR and PR rats, and significantly less arcuate NPY mRNA in PR and FR. In the dorsomedial hypothalamus, CR, PR, and FR rats had significantly increased NPY expression that was not normalized until the ER state. In response to a test meal, insulin and ghrelin release patterns were altered through the FR stage, and ghrelin remained affected at ER. Collectively, these data demonstrate that mere weight restoration is not sufficient to normalize hypothalamic gene expression levels and endocrine responses to a meal, and that meal-related ghrelin responses persist despite weight restoration for up to 4 wk.

Environmental Restoration Remedial Actions Program Field Office Work Plan

International Nuclear Information System (INIS)

1989-02-01

The Environmental Restoration Remedial Actions (ERRA) Program was established by DP to comply with regulations for characterization and cleanup of inactive waste sites. The program specifically includes inactive site identification and characterization, technology development and demonstration, remedial design and cleanup action, and postclosure activities of inactive radioactive, chemically hazardous, and mixed waste sites. It does not include facility decontamination and decommissioning activities; these are included in a parallel program, Environmental Restoration Decontamination and Decommissioning (ERD and D), also managed by DP. The ERRA program was formally established in fiscal year (FY) 1988 at the Hanford Site to characterize and remediate inactive waste sites at Hanford. The objectives, planned implementation activities, and management planning for the ERRA Program are contained in several planning documents. These documents include planning for the national program and for the Hanford Program. This summary describes the major documents and the role and purpose of this Field Office Work Plan (FOWP) within the overall hierarchy of planning documents. 4 refs., 7 figs., 8 tabs

Environmental restoration program pollution prevention checklist guide for the evaluation of alternatives project phase

International Nuclear Information System (INIS)

1993-09-01

Evaluation of alternative studies determine what decontamination and decommissioning (D ampersand D) alternatives are presented to regulators for facility and site cleanup. A key consideration in this process is the waste to be generated. Minimizing the volume and toxicity of this waste will ultimately contribute to the selection of the best clean-up option. The purpose of this checklist guide is to assist the user with incorporating pollution prevention/waste minimization (PP/WM) in all Evaluation of Alternatives (EV) phase projects of the Environmental Restoration (ER) Program. This guide will assist users with documenting PP/WM activities for technology transfer and reporting requirements. Automated computer screens will be created from the checklist data to help users implement and evaluate waste reduction. Users can then establish numerical performance measures to measure progress in planning, training, self-assessments, field implementation, documentation, and technology transfer. Cost savings result as users train and assess themselves, eliminating expensive process waste assessments and audit teams

Lace plant ethylene receptors, AmERS1a and AmERS1c, regulate ethylene-induced programmed cell death during leaf morphogenesis.

Science.gov (United States)

Rantong, Gaolathe; Evans, Rodger; Gunawardena, Arunika H L A N

2015-10-01

The lace plant, Aponogeton madagascariensis, is an aquatic monocot that forms perforations in its leaves as part of normal leaf development. Perforation formation occurs through developmentally regulated programmed cell death (PCD). The molecular basis of PCD regulation in the lace plant is unknown, however ethylene has been shown to play a significant role. In this study, we examined the role of ethylene receptors during perforation formation. We isolated three lace plant ethylene receptors AmERS1a, AmERS1b and AmERS1c. Using quantitative PCR, we examined their transcript levels at seven stages of leaf development. Through laser-capture microscopy, transcript levels were also determined in cells undergoing PCD and cells not undergoing PCD (NPCD cells). AmERS1a transcript levels were significantly lower in window stage leaves (in which perforation formation and PCD are occurring) as compared to all other leaf developmental stages. AmERS1a and AmERS1c (the most abundant among the three receptors) had the highest transcript levels in mature stage leaves, where PCD is not occurring. Their transcript levels decreased significantly during senescence-associated PCD. AmERS1c had significantly higher transcript levels in NPCD compared to PCD cells. Despite being significantly low in window stage leaves, AmERS1a transcripts were not differentially expressed between PCD and NPCD cells. The results suggested that ethylene receptors negatively regulate ethylene-controlled PCD in the lace plant. A combination of ethylene and receptor levels determines cell fate during perforation formation and leaf senescence. A new model for ethylene emission and receptor expression during lace plant perforation formation and senescence is proposed.

Analysis of Well ER-EC-2a Testing, Western Pahute Mesa-Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-2a during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-2a Data Report for Development and Hydraulic Testing.

Oak Ridge Reservation Federal Facility Agreement: Quarterly report for the Environmental Restoration Program. Volume 2, January--March 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

This report provides information about ER Program activities conducted on the Oak Ridge Reservation under the Federal Facility Agreement (FFA). Specifically, it includes information on milestones scheduled for completion during the reporting period as well as scheduled for completion during the next reporting period (quarter), accomplishments of the ER Program, concerns related to program work, and scheduled activities for the next quarter. It also provides a listing of the identity and assigned tasks of contractors performing ER Program work under the FFA.

Impact of occupational issues on DOE's environmental restoration program

International Nuclear Information System (INIS)

Siegel, M.R.; Lesperance, A.M.; Smith, D.

1992-01-01

The U.S. Department of Energy (DOE) is in the midst of a 30-yr, multi-billion-dollar environmental restoration program for most of the facilities included in its nuclear weapons complex. Long-term planning efforts are under way to identify strategies and approaches for carrying out this extraordinarily complicated task. The DOE has already entered into interagency agreements with the U.S. Environmental Protection Agency and states for many of its environmental restoration sites. These agreements set legally enforceable deadlines for cleanup activities at these sites. In addition, DOE has made other commitments to Congress and the public regarding its environmental restoration schedule. Thousands of workers will be directly involved in environmental restoration activities at DOE sites. Cleanup activity will be carried out in environments involving potential exposure to highly toxic chemical substances and radionuclides. It is inevitable that occupational safety and health (OSH) issues will become both critical and highly visible to DOE. The OSH issues associated with cleanup activities will likely attract the attention of workers, unions, the media, regulators, and the public. This paper reviews three case studies describing OSH activities in DOE's environmental restoration program. These case studies will help alert DOE officials to ways that various OSH issues should be considered when planning environmental restoration activities. This activity is being coordinated with other DOE work to identify occupational requirements that are applicable to DOE cleanup work

Environmental restoration activities at the US Department of Energy's Pinellas Plant

International Nuclear Information System (INIS)

Parker, M.W.

1991-01-01

The Pinellas Plant, located in Largo, Florida, is part of the US Department of Energy's (DOE) weapons complex. GE Neutron Devices (GEND) has initiated an extremely aggressive, proactive Environmental Restoration (ER) Program at the Pinellas Plant. The ER program was started by AL to investigate environmental concerns associated with past waste management practices and procedures at DOE weapons installations. The Pinellas Plant has been involved with ER activities since the mid 1980's when the DOE's Pinellas Area Office (PAO) entered a voluntary cleanup agreement with the Florida Department of Environmental Regulation (FDER). The agreement was for the remediation of an adjacent parcel of property previously owned, and used for disposal of drums containing waste solvents and resins. Remediation issues at the Pinellas Plant are equivalent to those experienced by many private industries; for example, limited volatile organic compound (VOC) and heavy metal contamination of the surficial aquifer system and heavy metal contamination of soils. ER activities in progress are aimed toward: confining, repositioning and remedying areas of heavy metal and VOC contaminants found within the surficial aquifer system; consistency with EPA's draft Corrective Action rules which state ''the corrective action program will be to expedite cleanup results by requiring (taking) sensible early action to control environmental problems;'' protection of a US Department of Interior (DOI) designated national wetland; and to ensure that risk to human health and safety and to the environment posed by the plants past, present and future operations are either eliminated or reduced to acceptable, safe levels. This paper will summarize the progress made and the strategies of the Pinellas Plant ER program as well as implementation of interim remedial actions

University of Tennessee and Oak Ridge environmental restoration education program

International Nuclear Information System (INIS)

Yalcintas, M.G.; Swindle, D.W. Jr.

1992-01-01

A joint program of the Oak Ridge National Laboratory (ORNL) and the University of Tennessee at Knoxville (UTK) has been initiated to provide education and research on environmental restoration and waste management. The program will provide opportunity for formal education and research for area businesses, while integrating their efforts in mixed-waste management with those of UTK and ORNL. Following successful results demonstrated at ORNL and UTK, the program will be integrated with other universities and research institutions in the country. During this presentation, the programs's objective, scope, and goals will be described, and details of the program structure will be explained. Also, it will be demonstrated how experience gained in environmental restoration technology transfer activities could be applied in an educational program, providing a focal point for technology transfer and information exchange. Expected accomplishments and industry benefits will also be discussed

The Soil Program of the Restoration Seedbank Initiative: addressing knowledge gaps in degraded soils for use in dryland restoration

Science.gov (United States)

Muñoz-Rojas, Miriam; Bateman, Amber; Erickson, Todd E.; Turner, Shane; Merritt, David J.

2017-04-01

Global environmental changes and other anthropogenic impacts are rapidly transforming the structure and functioning of ecosystems worldwide. These changes are leading to land degradation with an estimated 25 % of the global land surface being affected. Landscape-scale restoration of these degraded ecosystems has therefore been recognised globally as an international priority. In the resource-rich biodiverse semi-arid Pilbara region of north-west Western Australia hundreds of thousands of hectares are disturbed due to established and emerging iron-ore mine operations. At this scale, the need to develop cost-effective large-scale solutions to restore these landscapes becomes imperative to preserve biodiversity and achieve functionality and sustainability of these ecosystems. The Restoration Seedbank Initiative (RSB) (http://www.plants.uwa.edu.au/ research/restoration-seedbank-initiative) is a five-year multidisciplinary research project that aims to build knowledge and design strategies to restore mine-impacted landscapes in the Pilbara and other arid and semi-arid landscapes worldwide (Kildiseheva et al., 2016). The RSB comprises four research programs that focus on seedbank management and curation, seed storage, seed enhancement, and the use of alternative soil substrates (soil or growing medium program) respectively. These multi-disciplinary programs address the significant challenges of landscape scale restoration in arid systems. In the soil program we follow an integrated approach that includes the characterization of undisturbed ecosystems, assessment of restored soils with the use of soil quality indicators, and design of alternative soil substrates to support the establishment of native plant communities. A series of glasshouse studies and field trials have been conducted in the last three years to advance our knowledge on soil limitations and to provide solutions to effectively overcome these challenges in arid ecosystem restoration. These studies include

Integrating environmental restoration management within DOE using an alternative identification and evaluation procedure: A methodology and a case history

International Nuclear Information System (INIS)

Devaurs, M.; Brooks, D.; Kelly, E.; Wagner, S.; Vocke, R.

1992-01-01

The process of identifying and evaluating alternative corrective measures is a fundamental integrating part of Environmental Restoration (ER) activities. The process used in the Los Alamos National Laboratory (the Laboratory) ER Program is based on principles and tools from multiattribute decision analysis, a well-developed and proven method for evaluating options in decision situations involving multiple objectives, uncertainty, multiple interested stakeholders in the final decision, and the need for technical input from disparate disciplines. The process provides a methodology that has been extensively developed and reviewed over the past five decades; it provides a methodological structure for incorporating the concepts espoused in the streamlined approach as well as more specific guidelines such as data quality objectives (DQOs). The application of this methodology to the ER Program at Los Alamos is described in this paper

ER Consolidated Qtrly Rpt_April thru June 2015_October 2015

Energy Technology Data Exchange (ETDEWEB)

Cochran, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-10-01

This Sandia National Laboratories, New Mexico Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) fulfills all quarterly reporting requirements set forth in the Resource Conservation and Recovery Act Facility Operating Permit, and the Compliance Order on Consent. The 13 sites in the Corrective Action process are listed in Table I-1. Because the status of any Long-Term Stewardship (LTS) activity is detailed in other reports, Section I.3.0 (titled Long-Term Stewardship Work Completed) will not be presented in future ER Quarterly Reports. Section I.3.0 of this ER Quarterly Report identifies the other reports that detail LTS activities.

Environmental restoration value engineering guidance document

International Nuclear Information System (INIS)

1995-07-01

This document provides guidance on Value Engineering (VE). VE is an organized team effort led by a person trained in the methodology to analyze the functions of projects, systems, equipment, facilities, services, and processes for achieving the essential functions at the lowest life cycle cost while maintaining required performance, reliability, availability, quality, and safety. VE has proven to be a superior tool to improve up-front project planning, cut costs, and create a better value for each dollar spent. This document forms the basis for the Environmental Restoration VE Program, describes the VE process, and provides recommendations on when it can be most useful on ER projects

Sub-ablative Er,Cr:YSGG laser irradiation under all-ceramic restorations: effects on demineralization and shear bond strength.

Science.gov (United States)

Bağlar, Serdar

2018-01-01

This study evaluated the caries resistant effects of sub-ablative Er,Cr:YSGG laser irradiation alone and combined with fluoride in comparison with fluoride application alone on enamel prepared for veneer restorations. And also, evaluated these treatments' effects on the shear bond strength of all-ceramic veneer restorations. One hundred and thirty-five human maxillary central teeth were assigned to groups of 1a-control, 1b-laser treated, 1c-fluoride treated, 1d-laser + fluoride treated for shear bond testing and to groups of 2a-positive control(non-demineralised), 2b-laser treated, 2c-fluoride treated, 2d-laser + fluoride treated, 2e-negative control (demineralised) for microhardness testing (n = 15, N = 135). Demineralisation solutions of microhardness measurements were used for the ICP-OES elemental analysis. The parameters for laser irradiation were as follows: power output, 0.25 W; total energy density, 62.5 J/cm 2 and energy density per pulse, 4.48 J/cm 2 with an irradiation time of 20 s and with no water cooling. Five percent NaF varnish was used as fluoride preparate. ANOVA and Tukey HSD tests were performed (α = 5%). Surface treatments showed no significant effects on shear bond strength values (p = 0.579). However, significant differences were found in microhardness measurements and in elemental analysis of Ca and P amounts (p < 0.01). Surface-treated groups showed significantly high VNH values and significantly low ICP-OES values when compared with non-treated (-control) group while there were no significance among surface-treated groups regarding VHN and ICP-OES values. Sub-ablative Er,Cr:YSGG treatment alone or combined with fluoride is as an effective method as at least fluoride alone for preventing the prepared enamel to demineralization with no negative effect on shear bond strength.

Progress in the environmental restoration at the Savannah River Site (SRS)

International Nuclear Information System (INIS)

Pope, J.M.; McClain, L.

1992-01-01

The Environmental Restoration (ER) Program has continued to achieve significant accomplishments important to the mission of cleaning up inactive waste sites, performing corrective actions on contaminated groundwater, planning for decontaminating/decommissioning surplus facilities and ensuring that the environment and the health and safety of people are protected. The multifaceted cleanup at SRS represents noteworthy milestones across the DOE complex. The associated lessons learned and key elements of the progress will be presented in the course of the paper

Management of nonregulatory driven program risks

International Nuclear Information System (INIS)

Nielsen, R.R.; Hutterman, L.L.

1995-01-01

Evaluation of program risk is a significant part of any environmental restoration (ER) activity. While significant efforts have been made to assess risk to human health and the environment, program risks outside of CERCLA are handled on a fire drill basis. This paper explains a process that looks at program risk, directs mitigation efforts in the most useful path, and focuses corrective actions to obtain the most benefits from the resources used

Development of educational programs for environmental restoration/waste management at two Department of Energy sites

International Nuclear Information System (INIS)

Harrison, R.J.; Toth, W.J.; Smith, T.H.

1991-01-01

Availability of appropriately educated personnel is perhaps the greatest obstacle faced by the nation in addressing its waste management and environmental restoration activities. The US Department of Energy (DOE) Idaho National Engineering Laboratory (INEL) and the DOE Grand Junction, Colorado, Projects Office (GJPO) have developed two educational degree programs that respond to the human resource needs of the environmental restoration/waste management effort in ways that reflect the programmatic and cultural diversity at the two sites. The INEL has worked with the University of Idaho and Idaho States University to develop a set of master's degree programs focusing on waste management and environmental restoration. GJPO has developed an associate degree program and is developing a baccalaureate program in environmental restoration with Mesa State College. The development of these two programs was coordinated through the INEL University Relations Committee. They were conceived as parts of an overall effort to provide the human resources for environmental restoration and waste management. The background, need, and development of these two programs are presented, as well as information on associated industry parternships, employee scholarship programs, and plans for integration and articulation of curricula. 3 refs

Savannah River Site environmental restoration lessons learned program

International Nuclear Information System (INIS)

Plunkett, R.A.; Leibfarth, E.C.; Treger, T.M.; Blackmon, A.M.

1993-01-01

For the past three years environmental restoration has been formally consolidated at Savannah River Site. Accomplishments include waste site investigations to closure activities. Positive, as well as negatively impacting, events have occurred. Until recently, lessons learned were captured on a less than formal basis. Now, a program based upon critiques, evaluations and corrective actions is being used. This presentation reviews the development, implementation and use of that program

Motivation and Outcomes for University Students in a Restorative Justice Program

Science.gov (United States)

Gallagher Dahl, Meghan; Meagher, Peter; Vander Velde, Stacy

2014-01-01

A restorative justice program (RJP) was developed at a large university in the housing student conduct office. Students accused of misconduct who participated in a restorative justice (RJ) conference completed surveys regarding their motivations and perceived outcomes. Results showed that students who were motivated to make reparations to others…

Environmental restoration activities at the U.S. Department of Energy's Pinellas Plant

International Nuclear Information System (INIS)

Parker, Michael W.

1992-01-01

The Pinellas Plant, located in Largo, Florida, is part of the U.S. Department of Energy's (DOE) weapons complex. GE Neutron Devices (GEND) has initiated an extremely aggressive, proactive Environmental Restoration (ER) Program at the Pinellas Plant. The ER program was started by AL to investigate environmental concerns associated with past waste management practices and procedures at DOE weapons installations. The Pinellas Plant has been involved with ER activities since the mid 1980's when the DOE's Pinellas Area Office (PAO) entered a voluntary cleanup agreement with the Florida Department of Environmental Regulation (FDER). The agreement was for the remediation of an adjacent parcel of property previously owned, and used for disposal of drums containing waste solvents and resins. The ER program at the Pinellas Plant has been progressing rapidly since this inception, with ER activities currently initiated and/or planned at all sites where contaminants have been detected above regulatory standards. These activities operate under the State of Florida's 'Corrective Actions For Ground Water Contamination Cases' guidance and the Environmental Protection Agency's (EPA) Resource Conservation and Recovery Act (RCRA), as amended by the Hazardous and Solid Waste Amendments (HSWA) Corrective Action Rule and the requirements specified in the Hazardous Waste Part B Permit. Remediation issues at the Pinellas Plant are equivalent to those experienced by many private industries; for example, limited volatile organic compound (VOC) and heavy metal contamination of the surficial aquifer system and heavy metal contamination of soils. ER activities in progress are aimed toward; confining, repositioning and remedying areas of heavy metal and VOC contaminants found within the surficial aquifer system; consistency with EPA's draft Corrective Action Rules which state 'the corrective action program will be to expedite cleanup results by requiring (taking) sensible early action to control

Cost Estimating Handbook for Environmental Restoration

International Nuclear Information System (INIS)

1993-01-01

Environmental restoration (ER) projects have presented the DOE and cost estimators with a number of properties that are not comparable to the normal estimating climate within DOE. These properties include: An entirely new set of specialized expressions and terminology. A higher than normal exposure to cost and schedule risk, as compared to most other DOE projects, due to changing regulations, public involvement, resource shortages, and scope of work. A higher than normal percentage of indirect costs to the total estimated cost due primarily to record keeping, special training, liability, and indemnification. More than one estimate for a project, particularly in the assessment phase, in order to provide input into the evaluation of alternatives for the cleanup action. While some aspects of existing guidance for cost estimators will be applicable to environmental restoration projects, some components of the present guidelines will have to be modified to reflect the unique elements of these projects. The purpose of this Handbook is to assist cost estimators in the preparation of environmental restoration estimates for Environmental Restoration and Waste Management (EM) projects undertaken by DOE. The DOE has, in recent years, seen a significant increase in the number, size, and frequency of environmental restoration projects that must be costed by the various DOE offices. The coming years will show the EM program to be the largest non-weapons program undertaken by DOE. These projects create new and unique estimating requirements since historical cost and estimating precedents are meager at best. It is anticipated that this Handbook will enhance the quality of cost data within DOE in several ways by providing: The basis for accurate, consistent, and traceable baselines. Sound methodologies, guidelines, and estimating formats. Sources of cost data/databases and estimating tools and techniques available at DOE cost professionals

Søer 2000

DEFF Research Database (Denmark)

Jensen, J. P.; Søndergaard, M.; Jeppesen, E.

styrke det fagli-ge grundlag for de mil-jøpolitiske prioriteringer og beslut-ninger. En væsentlig del af denne opgave er overvågning af miljø og natur. Det er derfor et naturligt led i Danmarks Miljø-undersø-gelsers opgave at forestå den landsdækkende rapportering af overvågnings-program-met inden...

Potential CERCLA reauthorization issues relevant to US DOE's Environmental Restoration Program

International Nuclear Information System (INIS)

Siegel, M.R.; McKinney, M.D.; Jaksch, J.A.; Dailey, R.L.

1993-02-01

The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) is currently scheduled to be reauthorized in 1994. The US Department of Energy (DOE) has a significant stake in CERCLA reauthorization. CERCLA, along with its implementing regulation, the National Contingency Plan (NCP), is the principal legal authority governing DOE's environmental restoration program. The manner in which CERCLA-related issues are identified, evaluated, and dispatched may have a substantial impact on DOE's ability to conduct its environmental restoration program. A number of issues that impact DOE's environmental restoration program could be addressed through CERCLA reauthorization. These issues include the need to (1) address how the National Environmental Policy Act (NEPA) should be integrated into DOE CERCLA actions, (2) facilitate the streamlining of the Superfund process at DOE sites, (3) address the conflicts between the requirements of CERCLA and the Resource Conservation and Recovery Act (RCRA) that are especially relevant to DOE, (4) examine the criteria for waiving applicable or relevant and appropriate requirements (ARARs) at DOE sites, and (5) delineate the appropriate use of institutional controls at DOE sites

Strategic Environmental Research and Development Project FY 1994: Assessing national remote sensing technologies for use in US Department of Energy Environmental Restoration Activities, Oak Ridge Solid Waste Storage Area 4 case study

International Nuclear Information System (INIS)

King, A.L.; Smyre, J.L.; Evers, T.K.

1995-02-01

During FY 1994, the Oak Ridge Environmental Restoration (ER) Remote Sensing Program teamed with members of the Oak Ridge National Security Program Office (NSPO), the Environmental Research Institute of Michigan (ERIM) under contract to the National Exploitation Laboratory (NEL), the Oak Ridge Waste Area Group 4 (WAG 4) ER Program, and the US Department of Energy (DOE), Offices of Technology Development, Nonproliferation and National Security, and Environmental Restoration, to conduct a test and demonstration of the uses of national remote sensing technologies at DOE hazardous waste sites located in Oak Ridge, Tennessee. Objectives of the Oak Ridge study were to determine if national remote sensing technologies are useful in conducting prescreening, characterization, and/or monitoring activities to expedite the clean-up process at hazardous waste sites and to cut clean-up costs wherever possible. This project was sponsored by the Strategic Environmental Research and Development Project (SERDP)

Summary of activities of the life cycle costing workshop conducted by the Environmental Restoration Program of Oak Ridge National Laboratory

International Nuclear Information System (INIS)

1992-08-01

A five-day life cycle workshop was conducted by the Environmental Restoration (FR) Program of Oak Ridge National Laboratory (ORNL) to develop appropriate remediation scenarios for each Waste Area Grouping (WAG) at ORNL and to identify associated data needs (e.g., remedial investigations, special studies, and technology demonstrations) and required interfaces. Workshop participants represented the Department of Energy, Martin Marietta Energy Systems, Inc., Bechtel National, Radian Corporation, EBASCO Corporation, and M-K Ferguson. The workshop was used to establish a technical basis for remediation activities at each WAG. The workshop results are documented in this report and provide the baseline for estimating the technical scope for each WAG. The scope and associated budgets and schedules will be summarized in baseline reports for each WAG, which, in turn, will be compiled into an overall strategy document for ORNL ER

Evaluation of microleakage occurred in class V restoration prepared with Er:YAG laser and also with high speed, restored using composite; Avaliacao da microinfiltracao em cavidades classe V preparada com laser de Er:YAG ou alta rotacao, jateadas ou nao com bicarbonato de sodio e restauradas com resina composta

Energy Technology Data Exchange (ETDEWEB)

Junqueira, Angelo Maercio Finochio

2002-07-01

The microleakage is one of the great problems found in restoring dentistry. In spite of adhesive system evolution, several materials have been studied intending to minimize or to eliminate the microleakage occurred between the tooth and restorative material. The objective of this in vitro study was to evaluate and compare the marginal microleakage in class V cavities prepared by Er:YAG laser or high speed and restored with composite resin. One of the groups received the sodium bicarbonate jet while the other group have not received. Twenty teeth third extracted molars were sectioned in the sense medial-distal being obtained forty samples that were divided in four groups: Group I (G1): prepared with Er:YAG laser (2940 nm), E= 350 mJ/p, F=2 Hz, fluency of 112,5 J/cm{sup 2}. Preparing occlusion margin slice with 250 mJ/p, F=2 Hz, fluency of 80,3 J/cm{sup 2}. The prepared total area was irradiated with E=80 mJ/p, F=2 Hz and fluency of 25,75 J/cm{sup 2}. Every prepared area was finally submitted to sodium bicarbonate jet. Group 2 (G2): it was employed the same parameters used on group 1, except the sodium carbonate jet application. Group 3 (G3): the cavities' prepare were executed with high speed rotation using diamond cylindrical point. The slice confection has been made with the same point with 45 degrees inclined, utilizing also the sodium carbonate jet in all prepared area. Group 4 (G4): it was executed similarly prepared to group 3, without the sodium bicarbonate jet. In all the groups the cavities were washed with water spray and drought with air jet. Dentin and enamel surfaces have been conditioned with phosphoric acid at 35%. All the samples of all groups were restored using the single bond system adhesive and composite resin Z250, kept at 37 deg C in stove during 24 hours, thermally stressed, immersed in silver nitrate solution at 50% for 24 hours while kept in darkness. The specimens were soaked in photo developing solution and exposed to fluorescent light for

Evaluation of microleakage occurred in class V restoration prepared with Er:YAG laser and also with high speed, restored using composite; Avaliacao da microinfiltracao em cavidades classe V preparada com laser de Er:YAG ou alta rotacao, jateadas ou nao com bicarbonato de sodio e restauradas com resina composta

Energy Technology Data Exchange (ETDEWEB)

Junqueira, Angelo Maercio Finochio

2002-07-01

The microleakage is one of the great problems found in restoring dentistry. In spite of adhesive system evolution, several materials have been studied intending to minimize or to eliminate the microleakage occurred between the tooth and restorative material. The objective of this in vitro study was to evaluate and compare the marginal microleakage in class V cavities prepared by Er:YAG laser or high speed and restored with composite resin. One of the groups received the sodium bicarbonate jet while the other group have not received. Twenty teeth third extracted molars were sectioned in the sense medial-distal being obtained forty samples that were divided in four groups: Group I (G1): prepared with Er:YAG laser (2940 nm), E= 350 mJ/p, F=2 Hz, fluency of 112,5 J/cm{sup 2}. Preparing occlusion margin slice with 250 mJ/p, F=2 Hz, fluency of 80,3 J/cm{sup 2}. The prepared total area was irradiated with E=80 mJ/p, F=2 Hz and fluency of 25,75 J/cm{sup 2}. Every prepared area was finally submitted to sodium bicarbonate jet. Group 2 (G2): it was employed the same parameters used on group 1, except the sodium carbonate jet application. Group 3 (G3): the cavities' prepare were executed with high speed rotation using diamond cylindrical point. The slice confection has been made with the same point with 45 degrees inclined, utilizing also the sodium carbonate jet in all prepared area. Group 4 (G4): it was executed similarly prepared to group 3, without the sodium bicarbonate jet. In all the groups the cavities were washed with water spray and drought with air jet. Dentin and enamel surfaces have been conditioned with phosphoric acid at 35%. All the samples of all groups were restored using the single bond system adhesive and composite resin Z250, kept at 37 deg C in stove during 24 hours, thermally stressed, immersed in silver nitrate solution at 50% for 24 hours while kept in darkness. The specimens were soaked in photo developing solution and exposed to fluorescent

200 Areas Remedial Investigation/Feasibility Study Implementation Plan - Environmental Restoration Program

International Nuclear Information System (INIS)

Knepp, A. J.

1999-01-01

The 200 Areas Remedial Investigation/Feasibility Study Implementation Plan - Environmental Restoration Program (Implementation Plan) addresses approximately 700 soil waste sites (and associated structures such as pipelines) resulting from the discharge of liquids and solids from processing facilities to the ground (e.g., ponds, ditches, cribs,burial grounds) in the 200 Areas and assigned to the Environmental Restoration Program. The Implementation Plan outlines the framework for implementing assessment activities in the 200 Areas to ensure consistency in documentation, level of characterization, and decision making. The Implementation Plan also consolidates background information and other typical work plan materials, to serve as a single referenceable source for this type of information

Risk-based priority scoring for Brookhaven National Laboratory environmental restoration programs

International Nuclear Information System (INIS)

Morris, S.C.; Meinhold, A.F.

1995-05-01

This report describes the process of estimating the risk associated with environmental restoration programs under the Brookhaven National Laboratory Office of Environmental Restoration. The process was part of an effort across all Department of Energy facilities to provide a consistent framework to communicate risk information about the facilities to senior managers in the DOE Office of Environmental Management to foster understanding of risk activities across programs. the risk evaluation was a qualitative exercise. Categories considered included: Public health and safety; site personnel safety and health; compliance; mission impact; cost-effective risk management; environmental protection; inherent worker risk; environmental effects of clean-up; and social, cultural, political, and economic impacts

Planning aquatic ecosystem restoration monitoring programs

Energy Technology Data Exchange (ETDEWEB)

Thom, R.M.; Wellman, K.F.

1997-01-01

This study was conducted as part of the Evaluation of Environmental Investments Research Program (EEIRP). The EEIRP is sponsored by the US Army Corps of Engineers. The objectives of this work are to (1) identify relevant approaches and features for environmental investment measures to be applied throughout the project life; (2) develop methods to access the effectiveness of the approach or feature for providing the intended environmental output; (3) develop and provide guidance for formulating environmental projects; and (4) provide guidance for formulating and identifying relevant cost components of alternate restoration plans.

Environmental Restoration Program pollution prevention checklist guide for the facility characterization project phase

International Nuclear Information System (INIS)

1993-09-01

A facility characterization (FC) is conducted to determine the nature and extent contamination at a potential hazardous facility waste site. The information gathered during an FC includes (1) data on the volume and chemical nature of the waste, (2) information on the extent of contamination and the migration potential of the contaminants, (3) preliminary information on evaluation of alternative concepts that can or cannot be considered, and (4)supportive technical and cost data. For the purposes of identification, the following operational phases will be used for definition for this phase of the decommissioning and decontamination process (1) facility characterization before clean up, (2) characterization during clean up, (3) characterization of waste materials, and (4) site characterization after clean up. A key consideration in this process is the prevention of any waste to be generated from these characterization activities. The purpose of this checklist guide is to assist users with incorporating pollution prevention/waste minimization (PP/WM) in all FC phase projects of the Environmental Restoration (ER) Program. This guide will help users document PP/WM activities for technology transfer and reporting requirements. Automated computer screens will be created from the checklist data to assist users with implementing and evaluating waste reduction

Y-12 Plant Decontamination and Decommissioning Program

International Nuclear Information System (INIS)

1992-01-01

The Decontamination and Decommissioning (D and D) Program at the Oak Ridge Y-12 Plant is part of the Environmental Restoration (ER) and Waste Management (WM) Programs (ERWM). The objective of the ER Program is to provide Y-12 the capability to meet applicable environmental regulations through facility development activities and site remedial actions. The WM Program supports the ER program. The D and D Program provides collective management of sites within the Plant which are in need of decontamination and decommissioning efforts, prioritizes those areas in terms of health, safety, and environmental concerns, and implements the appropriate level of remedial action. The D and D Program provides support to identifiable facilities which formerly served one or more of the many Plant functions. Program activities include (1) surveillance and maintenance of facilities awaiting decommissioning; (2) planning safe and orderly facility decommissioning; and (3) implementing a program to accomplish facility disposition in a safe, cost effective, and timely manner. In order to achieve the first objective, a formal plan which documents the surveillance and maintenance needs for each facility has been prepared. This report provides this documentation for the Y-12 facilities currently included in the D and D Program, as well as those planned for future inclusion in the Program, and includes projected resource requirements for the planning period of FY 1993 through FY 2000

International technology transfer to support the environmental restoration needs of the DOE complex

International Nuclear Information System (INIS)

DuCharme, A.R.; Jimenez, R.D.; Roberds, W.J.

1992-01-01

One of the principal objectives of the International Technology Exchange Program (ITEP) is the exchange of waste management and environmental restoration (WM/ER) technologies between the US and other nations. The current emphasis of ITEP is the transfer of technologies to the US that could provide better, faster, cheaper, or safer solutions to the needs of the DOE complex. The 10 candidate technologies that have been identified thus far by ITEP are discussed. The highlights of preliminary evaluations of these technologies through a systems approach are also described. The technologies have been evaluated by a screening process to determine their applicability to the leading WM/ER needs of the DOE complex. The technologies have been qualitatively compared with the known or anticipated capabilities of domestic, base case technologies

Ecological restoration, ecosystem services, and land use: a European perspective

Directory of Open Access Journals (Sweden)

Anne Tolvanen

2016-12-01

Full Text Available This special feature provides an overview on how the ecosystem service concept has been and can be incorporated into the science, practice, and policies of ecological restoration (ER and evidence-based land-use. It includes an edited selection of eleven invited and peer-reviewed papers based on presentations given during the 9th European Conference on Ecological Restoration in 2014. The focus is on Europe, but many contributors also make appraisals and recommendations at the global scale. Based on the contributors' papers, and our own overview of the promise of ecological restoration in the existing international treaties, coalitions, and conventions, we propose that the following actions could contribute to the positive impacts of ER on biodiversity maintenance, ecosystem functioning, progressive mainstreaming the concepts of both ER and ecosystem services, significant mitigation and offsetting of anthropogenic climate change, and lasting enhancement of both ecosystem and human health: •\tER should be incorporated into land use planning, wherever needed, and the synergies and trade-offs of different land use scenarios should be assessed in terms of their impacts on ecosystem services. •\tThe discourse of ER should be enlarged, wherever it is needed, to include multifunctional land use that simultaneously supports sustainable production systems, built environments, and the quality and quantity of diverse ecosystem services. This approach will generate ecological, social, and economic benefits in the long run. •\tMonitoring and evaluation of ER projects should be a continuous process involving careful selection of indicators chosen with the full range of stakeholders in mind, and a sufficiently long-term perspective to catch the progress of long-term or highly dynamic ecosystem processes. •\tScientists should actively participate in policy and land management discussions in order to give their views on the potential outcomes of decisions. �

Environmental restoration baselining as a means of successful performance

International Nuclear Information System (INIS)

Fourr, B.R.; Pilo, M.A.; Hastings, K.R.

1994-01-01

The Idaho National Engineering Laboratory (INEL) Environmental Restoration (ER) Program is a success story for the U.S. Department of Energy Environmental Management Program (DOE-EM) with 9 Records of Decision (ROD's) signed, 5 CERCLA Interim Actions complete or in progress, 8 Expedited Removal Actions either planned, complete or in progress, and cleanup activity underway at over 60 percent of the 88 operable units. More than 50% of Idaho's budget for Fiscal Year (FY94) is targeted for cleanup activities, and starting in FY95, more than twice as much will be spent on cleanup as assessment. The INEL ER Program can serve as a model for other EM programs striving to meet the goals of the EM Strategic Plan. An important factor in the INEL success story is the work planning which takes place each year to integrate the DOE-EM budget process, the legal requirements of the Federal Facilities Agreement and Consent Order (FFA/CO), and the interests of stakeholders. This integration is no small task given that Activity Data Sheets (ADS), which are DOE-EM's primary budget document are prepared and submitted to DOE Headquarters (DOE-HQ) about 18 months prior to the start of the budget year. The ADS form the basis of budget negotiations between DOE-EM, the Office of Management and Budget (OMB) and Congress. Actual funding is not known until the start of the fiscal year

A Dynamic Programming based method for optimizing power system restoration with high wind power penetration

DEFF Research Database (Denmark)

Hu, Rui; Hu, Weihao; Li, Pengfei

2016-01-01

and relatively low cost. Thus, many countries are increasing the wind power penetration in their power system step by step, such as Denmark, Spain and Germany. The incremental wind power penetration brings a lot of new issues in operation and programming. The power system sometimes will operate close to its...... stable limits. Once the blackout happens, a well-designed restoration strategy is significant. This paper focuses on how to ameliorate the power system restoration procedures to adapt the high wind power penetration and how to take full advantages of the wind power plants during the restoration....... In this paper, the possibility to exploit the stochastic wind power during restoration was discussed, and a Dynamic Programming (DP) method was proposed to make wind power contribute in the restoration rationally as far as possible. In this paper, the method is tested and verified by a modified IEEE 30 Buses...

Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.

Science.gov (United States)

Shchors, Ksenya; Persson, Anders I; Rostker, Fanya; Tihan, Tarik; Lyubynska, Natalya; Li, Nan; Swigart, Lamorna Brown; Berger, Mitchel S; Hanahan, Douglas; Weiss, William A; Evan, Gerard I

2013-04-16

Based on clinical presentation, glioblastoma (GBM) is stratified into primary and secondary types. The protein 53 (p53) pathway is functionally incapacitated in most GBMs by distinctive type-specific mechanisms. To model human gliomagenesis, we used a GFAP-HRas(V12) mouse model crossed into the p53ER(TAM) background, such that either one or both copies of endogenous p53 is replaced by a conditional p53ER(TAM) allele. The p53ER(TAM) protein can be toggled reversibly in vivo between wild-type and inactive conformations by administration or withdrawal of 4-hydroxytamoxifen (4-OHT), respectively. Surprisingly, gliomas that develop in GFAP-HRas(V12);p53(+/KI) mice abrogate the p53 pathway by mutating p19(ARF)/MDM2 while retaining wild-type p53 allele. Consequently, such tumors are unaffected by restoration of their p53ER(TAM) allele. By contrast, gliomas arising in GFAP-HRas(V12);p53(KI/KI) mice develop in the absence of functional p53. Such tumors retain a functional p19(ARF)/MDM2-signaling pathway, and restoration of p53ER(TAM) allele triggers p53-tumor-suppressor activity. Congruently, growth inhibition upon normalization of mutant p53 by a small molecule, Prima-1, in human GBM cultures also requires p14(ARF)/MDM2 functionality. Notably, the antitumoral efficacy of p53 restoration in tumor-bearing GFAP-HRas(V12);p53(KI/KI) animals depends on the duration and frequency of p53 restoration. Thus, intermittent exposure to p53ER(TAM) activity mitigated the selective pressure to inactivate the p19(ARF)/MDM2/p53 pathway as a means of resistance, extending progression-free survival. Our results suggest that intermittent dosing regimes of drugs that restore wild-type tumor-suppressor function onto mutant, inactive p53 proteins will prove to be more efficacious than traditional chronic dosing by similarly reducing adaptive resistance.

Using cost/risk uncertainty spheres to make better environmental restoration decisions

International Nuclear Information System (INIS)

Shangraw, R.F.; Cheney, C.S.; Shangraw, W.R.

1994-01-01

The process of balancing cost expenditures and risk reductions during environmental restoration (ER) activities (and as part of other environmental programs such as waste management and facility transition) is the critical policy decision facing DOE site decisionmakers and associated stakeholders (including regulators). The ground rules for this process are specified formally in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended, the Resource Conservation and Recovery Act, as amended, the subsequent regulations (e.g., National Contingency Plan) and policies that EPA and State agencies have issued to implement these programs, and (increasingly) interagency agreements and orders. Clearly, as Federal resources to meet environmental commitments become more constrained, cost and risk management tradeoffs will become even more needed and their results pronounced

Environmental Restoration/Waste Management - applied technology. Semiannual report, July 1992--June 1993, Volume 1, Number 2, and Volume 2, Number 1

International Nuclear Information System (INIS)

Murphy, P.W.; Bruner, J.M.; Price, M.E.; Talaber, C.J.

1993-01-01

The Environmental Restoration/Waste Management-Applied Technology (ER/WM-AT) Program is developing restoration and waste treatment technologies needed for the ongoing environmental cleanup of the Department of Energy (DOE) complex and treatment technologies for wastes generated in the nuclear weapons production complex. These technologies can find application to similar problems nationally and even worldwide. They can be demonstrated at the Livermore site, which mirrors (on a small scale) many of the environmental and waste management problems of the rest of the DOE complex. Their commercialization should speed cleanup, and the scope of the task should make it attractive to US industry. The articles in this semi-annual report cover the following areas: ceramic final forms for residues of mixed waste treatment; treatment of wastes containing sodium nitrate; actinide volatility in thermal oxidation processes; in situ microbial filters for remediating contaminated soils; collaboration with scientists in the former Soviet Union on new ER/WM technologies; and fiber-optic sensors for chlorinated organic solvents

A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis.

Science.gov (United States)

Joshi, Amit S; Huang, Xiaofang; Choudhary, Vineet; Levine, Tim P; Hu, Junjie; Prinz, William A

2016-11-21

Saccharomyces cerevisiae contains three conserved reticulon and reticulon-like proteins that help maintain ER structure by stabilizing high membrane curvature in ER tubules and the edges of ER sheets. A mutant lacking all three proteins has dramatically altered ER morphology. We found that ER shape is restored in this mutant when Pex30p or its homologue Pex31p is overexpressed. Pex30p can tubulate membranes both in cells and when reconstituted into proteoliposomes, indicating that Pex30p is a novel ER-shaping protein. In contrast to the reticulons, Pex30p is low abundance, and we found that it localizes to subdomains in the ER. We show that these ER subdomains are the sites where most preperoxisomal vesicles (PPVs) are generated. In addition, overproduction or deletion of Pex30p or Pex31p alters the size, shape, and number of PPVs. Our findings suggest that Pex30p and Pex31p help shape and generate regions of the ER where PPV biogenesis occurs.

The economics of restoration: looking back and leaping forward.

Science.gov (United States)

Blignaut, James; Aronson, James; de Wit, Martin

2014-08-01

Since the publication of the Millennium Ecosystem Assessment in 2005 there has been a surge of interest in ecological restoration (ER) to recover biodiversity, re-establish ecosystem functioning and connectivity, and reactivate the delivery of ecosystem services. In policy spheres, there have also been repeated calls for expansion of restoration efforts. In many countries, new legislation now requires some form of restoration and/or a form of offset investment. All of this will require major increases in financial allocations toward restoration science, technology, and implementation, and much more detailed valuation techniques. The economics of restoration is a new field emerging to support these needs. Our paper here starts with an analysis of the articles and reviews published on this broad subject from 1928 to 2012, as captured in the Scopus academic search platform. Our goal is to present and summarize what has been said and done in this area to date. Next, we map out one possible way forward, illustrated by examples and based on a coherent bundle of decision parameters related to the economics of ER and, more broadly, to the restoration of natural capital. The restoration of natural capital is defined as activities that integrate investment in, and replenishment of, natural capital stocks to improve the flows of ecosystem goods and services, and the preservation of biodiversity, while enhancing all aspects of human well-being. We give special attention to system dynamic approaches and other promising tools and techniques. © 2014 New York Academy of Sciences.

RESTORATION PLUS: A COLLABORATIVE ENVIRONMENTAL PROTECTION AGENCY RESEARCH PROGRAM TO DEVELOP AND EVALUATE ECOSYSTEM RESTORATION AND MANAGEMENT OPTIONS TO ACHIEVE ECOLOGICALLY AND ECONOMICALLY SUSTAINABLE SOLUTIONS

Science.gov (United States)

The U.S. Environmental Protection Agency (U.S. EPA) is evaluating ecosystem restoration and management techniques to ensure they create sustainable solutions for degraded watersheds. The ORD/NRMRL initiated the Restoration Plus (RePlus) program in 2002, which emphasizes collabora...

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics

Science.gov (United States)

Bravo, Roberto; Gutierrez, Tomás; Paredes, Felipe; Gatica, Damián; Rodriguez, Andrea E.; Pedrozo, Zully; Chiong, Mario; Parra, Valentina; Quest, Andrew F.G.; Rothermel, Beverly A.; Lavandero, Sergio

2014-01-01

Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating damaged cells. The molecular mechanisms responsible for execution of the cell death program are relatively well characterized, but the metabolic events taking place during the adaptive phase of ER stress remain largely undefined. Here we discuss emerging evidence regarding the metabolic changes that occur during the onset of ER stress and how ER influences mitochondrial function through mechanisms involving calcium transfer, thereby facilitating cellular adaptation. Finally, we highlight how dysregulation of ER–mitochondrial calcium homeostasis during prolonged ER stress is emerging as a novel mechanism implicated in the onset of metabolic disorders. PMID:22064245

Initial robotics research for environmental restoration and waste management

International Nuclear Information System (INIS)

Hamel, W.R.; Mann, R.C.

1990-01-01

This paper describes the initial research and development activities at the Oak Ridge National Laboratory (ORNL) that will support the technology development component of the overall National Robotics Technology Development Program (NRTDP). The NRTDP is a subelement of the US Department of Energy's (DOE's) Environmental Restoration and Waste Management (ER and WM) 5-Year Applied Research, Development, Demonstration, Testing, and Evaluation Plan and of overall efforts at DOE operational sites around the country. ORNL research will focus on fundamental improvement of remote manipulation through enhancements of the human man/machine interface, integration of automated functions, and the incorporation of machine intelligence to increase productivity. Background and goals for these activities are presented in this paper

Monitoring habitat restoration projects: U.S. Fish and Wildlife Service Pacific Region Partners for Fish and Wildlife Program and Coastal Program Protocol

Science.gov (United States)

Woodward, Andrea; Hollar, Kathy

2011-01-01

The U.S. Fish and Wildlife Service's (FWS) Pacific Region (Region 1) includes more than 158 million acres (almost 247,000 square miles) of land base in Idaho, Oregon, Washington, Hawai`i, the Commonwealth of the Northern Mariana Islands, American Samoa, Guam, the Republic of Palau, the Federated States of Micronesia, and the Republic of the Marshall Islands. Region 1 is ecologically diverse with landscapes that range from coral reefs, broadleaf tropical forests, and tropical savannahs in the Pacific Islands, to glacial streams and lakes, lush old-growth rainforests, inland fjords, and coastal shoreline in the Pacific Northwest, to the forested mountains, shrub-steppe desert, and native grasslands in the Inland Northwest. Similarly, the people of the different landscapes perceive, value, and manage their natural resources in ways unique to their respective regions and cultures. The Partners for Fish and Wildlife Program (Partners Program) and Coastal Program work with a variety of partners in Region 1 including individual landowners, watershed councils, land trusts, Soil and Water Conservation Districts, non-governmental organizations, Tribal governments, Native Hawaiian organizations, and local, State, and Federal agencies. The Partners Program is the FWS's vanguard for working with private landowners to voluntarily restore and conserve fish and wildlife habitat. Using non-regulatory incentives, the Partners Program engages willing partners to conserve and protect valuable fish and wildlife habitat on their property and in their communities. This is accomplished by providing the funding support and technical and planning tools needed to make on-the-ground conservation affordable, feasible, and effective. The primary goals of the Pacific Region Partners Program are to: Promote citizen and community-based stewardship efforts for fish and wildlife conservation Contribute to the recovery of at-risk species, Protect the environmental integrity of the National Wildlife

Environmental Restoration Program Roadmap: Strategic program plan

International Nuclear Information System (INIS)

1992-01-01

This document is a strategic plan for accomplishing environmental restoration objectives at the Department of Energy's (DOE) Portsmouth Gaseous Diffusion Plant (PORTS). Waste Management (WM) for environmental restoration activities and integration of these activities into the PORTS WM operations is addressed in this document. The document provides detailed information concerning specific assumptions and activities required to meet DOE's environmental restoration objectives at this site. Environmental contamination at PORTS consists mainly of spent solvents and low level radionuclides. Solvents were used for industrial metal cleaning operations required to maintain the process during operations. Plumes of groundwater contamination resulting from past disposal of these spent solvents in landfills and impoundments extend from several locations within the site. Also, two sludge impoundments associated with a chromate reduction facility were characterized as having soil and groundwater contaminated with hexavalent chromium

Expanding a community's justice response to sex crimes through advocacy, prosecutorial, and public health collaboration: introducing the RESTORE program.

Science.gov (United States)

Koss, Mary P; Bachar, Karen J; Hopkins, C Quince; Carlson, Carolyn

2004-12-01

Problems in criminal justice system response to date-acquaintance rape and nonpenetration sexual offenses include (a) they are markers of a sexual offending career, yet are viewed as minor; (b) perpetrators are not held accountable in ways that reduce reoffense; and (c) criminal justice response disappoints and traumatizes victims. To address these problems, a collaboration of victim services, prosecutors, legal scholars, and public health professionals are implementing and evaluating RESTORE, a victim-driven, community-based restorative justice program for selected sex crimes. RESTORE prepares survivors, responsible persons (offenders), and both parties' families and friends for face-to-face dialogue to identify the harm and develop a redress plan. The program then monitors the offender's compliance for 12 months. The article summarizes empirical data on problems in criminal justice response, defines restorative justice models, and examines outcome. Then the RESTORE program processes and goals are described. The article highlights community collaboration in building and sustaining this program.

Environmental restoration and decontamination and decommissioning safety documentation

International Nuclear Information System (INIS)

Hansen, J.L.; Frauenholz, L.H.; Kerr, N.R.

1993-01-01

This document presents recommendations of a working group designated by the Environmental Restoration and Remediation (ER) and Decontamination and Decommissioning (D ampersand D) subcommittees of the Westinghouse M ampersand O (Management and Operation) Nuclear Facility Safety Committee. A commonalty of approach to safety documentation specific to ER and D ampersand D activities was developed and is summarized below. Allowance for interpretative tolerance and documentation flexibility appropriate to the activity, graded for hazard category, duration, and complexity, was a primary consideration in development of this guidance

Summary of available waste forecast data for the Environmental Restoration Program at the Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1994-08-01

This report identifies patterns of Oak Ridge National Laboratory (ORNL) Environmental Restoration (ER) waste generation that are predicted by the current ER Waste Generation Forecast data base. It compares the waste volumes to be generated with the waste management capabilities of current and proposed treatment, storage, or disposal (TSD) facilities. The scope of this report is limited to wastes generated during activities funded by the Office of the Deputy Assistant Secretary for Environmental Restoration (EM-40) and excludes wastes from the decontamination and decommissioning of facilities. Significant quantities of these wastes are expected to be generated during ER activities. This report has been developed as a management tool supporting communication and coordination of waste management activities at ORNL. It summarizes the available data for waste that will be generated as a result of remediation activities under the direction of the U.S. Department of Energy Oak Ridge Operations Office and identifies areas requiring continued waste management planning and coordination. Based on the available data, it is evident that most remedial action wastes leaving the area of contamination can be managed adequately with existing and planned ORR waste management facilities if attention is given to waste generation scheduling and the physical limitations of particular TSD facilities. Limited use of off-site commercial TSD facilities is anticipated, provided the affected waste streams can be shown to satisfy the requirements of the performance objective for certification of non-radioactive hazardous waste and the waste acceptance criteria of the off-site facilities. Ongoing waste characterization will be required to determine the most appropriate TSD facility for each waste stream

Persistent ER stress induces the spliced leader RNA silencing pathway (SLS, leading to programmed cell death in Trypanosoma brucei.

Directory of Open Access Journals (Sweden)

Hanoch Goldshmidt

2010-01-01

Full Text Available Trypanosomes are parasites that cycle between the insect host (procyclic form and mammalian host (bloodstream form. These parasites lack conventional transcription regulation, including factors that induce the unfolded protein response (UPR. However, they possess a stress response mechanism, the spliced leader RNA silencing (SLS pathway. SLS elicits shut-off of spliced leader RNA (SL RNA transcription by perturbing the binding of the transcription factor tSNAP42 to its cognate promoter, thus eliminating trans-splicing of all mRNAs. Induction of endoplasmic reticulum (ER stress in procyclic trypanosomes elicits changes in the transcriptome similar to those induced by conventional UPR found in other eukaryotes. The mechanism of up-regulation under ER stress is dependent on differential stabilization of mRNAs. The transcriptome changes are accompanied by ER dilation and elevation in the ER chaperone, BiP. Prolonged ER stress induces SLS pathway. RNAi silencing of SEC63, a factor that participates in protein translocation across the ER membrane, or SEC61, the translocation channel, also induces SLS. Silencing of these genes or prolonged ER stress led to programmed cell death (PCD, evident by exposure of phosphatidyl serine, DNA laddering, increase in reactive oxygen species (ROS production, increase in cytoplasmic Ca(2+, and decrease in mitochondrial membrane potential, as well as typical morphological changes observed by transmission electron microscopy (TEM. ER stress response is also induced in the bloodstream form and if the stress persists it leads to SLS. We propose that prolonged ER stress induces SLS, which serves as a unique death pathway, replacing the conventional caspase-mediated PCD observed in higher eukaryotes.

Environmental restoration technology programs at Mesa State College: A strategic look at manpower needs

International Nuclear Information System (INIS)

Harrison, R.J.; Emilia, D.A.

1991-01-01

The environmental cleanup of Department of Energy (DOE) sites within the next 30 years requires strategic planning to ensure adequate manpower is available when needed. Manpower needs projections within DOE have been based on analyses of current industry trends that indicate a substantial shortage of scientists and engineers. This paper explores the idea that the manpower requirements of DOE's environmental restoration program are not yet fully realized by most sites, which are currently in the predecisional work phase. Experience at the Grand Junction Projects Office (GJPO), which has had environmental restoration as it primary mission for about 10 years, shows that in the postdecisional phases the manpower need for scientists and engineers decreases while the manpower need for technologists in technical, management, and support roles increases. The GJPO, with Mesa State College in Grand Junction, Colorado, has developed an Environmental Restoration Associate degree program based on a strategic look at its manpower needs. This program receives start-up funding from DOE and has received donations in the million dollar range from various industry and state government partners

Clinch River Environmental Restoration Program

International Nuclear Information System (INIS)

Cook, R.B.

1992-01-01

This report consists of tables and listings from the results of the Phase I data gathering activities of the Clinch River Environmental Restoration Program (CR-ERP). The table of contents outlines the presentation of the material and has been annotated to indicate the key fields used to order the printing of each data table. Definitions of selected column headings are provided. Sample collection information is shown first and then more specific information for each matrix type is presented. The analytical results have been reviewed by independent validators and the qualifiers shown are the results of their efforts. No data that were rejected by the validation process are included in this listing. Only results of routine samples are listed; quality control sample results were excluded. All data, both detected and nondetected values, were used to calculated the summary table values. However, only Detected values are given on the analyte specific listings

3-D subsurface modeling within the framework of an environmental restoration information system: Prototype results using earthvision

International Nuclear Information System (INIS)

Goeltz, R.T.; Zondlo, T.F.

1994-01-01

As a result of the DOE Oak Ridge Reservation (DOE-ORR) placement on the EPA Superfund National Priorities List in December of 1989, all remedial activities, including characterization, remedial alternatives selection, and implementation of remedial measures, must meet the combined requirements of RCRA, CERCLA, and NEPA. The Environmental Restoration Program, therefore, was established with the mission of eliminating or reducing to prescribed safe levels the risks to the environment or to human health and safety posed by inactive and surplus DOE-ORR managed sites and facilities that have been contaminated by radioactive and surplus DOE-ORR managed sites and facilities that have been contaminated by radioactive, hazardous, or mixed wastes. In accordance with an established Federal Facilities Agreement (FFA), waste sites and facilities across the DOE-ORR have been inventoried, prioritized, and are being systematically investigated and remediated under the direction of Environmental Restoration. EarthVision, a product of Dynamic Graphics, Inc., that provides three-dimensional (3-D) modeling and visualization, was exercised within the framework of an environmental restoration (ER) decision support system. The goal of the prototype was to investigate framework integration issues including compatibility and value to decision making. This paper describes the ER program, study site, and information system framework; selected EarthVision results are shown and discussed. EarthVision proved effective in integrating complex data from disparate sources and in providing 3-D visualizations of the spatial relationships of the data, including contaminant plumes. Work is under way to expand the analysis to the full site, covering about 1600 acres, and to include data from new sources, particularly remote-sensing studies

Nuclear facility decommissioning and site remedial actions: A selected bibliography, Volume 12. Environmental Restoration Program

Energy Technology Data Exchange (ETDEWEB)

1991-09-01

The 664 abstracted references on environmental restoration, nuclear facility decommissioning, uranium mill tailings management, and site remedial actions constitute the twelfth in a series of reports prepared annually for the US Department of Energy Remedial Action Programs. Citations to foreign and domestic literature of all types -- technical reports, progress reports, journal articles, symposia proceedings, theses, books, patents, legislation, and research project descriptions -- have been included. The bibliography contains scientific, technical, economic, regulatory, and legal information pertinent to the US Department of Energy Remedial Action Programs. Major sections are (1) Decontamination and Decommissioning Program, (2) Nuclear Facilities Decommissioning, (3) Formerly Utilized Sites Remedial Action Program, (4) Facilities Contaminated with Naturally Occurring Radionuclides, (5) Uranium Mill Tailings Remedial Action Program, (6) Uranium Mill Tailings Management, (7) Technical Measurements Center, and (8) Environmental Restoration Program. Within these categories, references are arranged alphabetically by first author. Those references having no individual author are listed by corporate affiliation or by publication title. Indexes are provided for author, corporate affiliation, title word, publication description, geographic location, subject category, and key word. This report is a product of the Remedial Action Program Information Center (RAPIC), which selects, analyzes, and disseminates information on environmental restoration and remedial actions. RAPIC staff and resources are available to meet a variety of information needs. Contact the center at FTS 624-7764 or (615) 574-7764.

Oak restoration trials: Santa Catalina Island

Science.gov (United States)

Lisa Stratton

2002-01-01

Two restoration trials involving four oak species have been implemented as part of a larger restoration program for Catalina Island. In 1997 the Catalina Island Conservancy began an active program of restoration after 50 years of ranching and farming activities on the island. The restoration program includes removing feral goats and pigs island-wide and converting 80...

Er:YAG pre-treatment for bonding of orthodontic bracket: 1 year of in vitro treatment

Directory of Open Access Journals (Sweden)

de Jesus Tavarez RR

2017-03-01

Full Text Available Rudys Rodolfo de Jesus Tavarez,1 Gisele Lima Bezerra,2 Karla Janilee de Souza Penha,3 Carlos Rocha Gomes Torres,4 Leily Macedo Firoozmand5 1Department of Dentistry, Ceuma University (UNICEUMA, 2Dentistry Program, Ceuma University (UNICEUMA, 3Dentistry Program, Federal University of Maranhão, UFMA, São Luís, MA, 4Restorative Dentistry Department, ICT UNESP University, São Paulo, 5Dentistry Department I, Federal University of Maranhão,UFMA, São Luís, MA, Brazil Objective: The aim of this study was to evaluate in vitro bond strength of metal brackets bonded with: total etch, total etch with erbium: yttrium aluminum garnet laser (Er:YAG and self-etching adhesive systems, submitted to thermal-mechanical cycling, simulating 1 year of orthodontic treatment.Materials and methods: For the study, 80 bovine incisors were randomly divided into 3 experimental groups (n=16 each: XT- acid etching + Transbond XT, XT/Er:YAG- Transbond XT associated with Er:YAG laser irradiation (λ=2.94 μm, 60 mJ, 10 Hz and SEP- Transbond Plus Self Etching Primer. Samples were submitted to thermal-mechanical cycling, simulating 1 year of orthodontic treatment. Afterward, the shear bond strength test was performed in a universal test machine at a speed of 0.5mm/min. Samples were evaluated under a stereomicroscope and by scanning electron microscopy for analysis of enamel surface and adhesive remnant index. Data were analyzed using Kruskal–Wallis and Mann–Whitney (with Bonferroni correction statistical tests.Results: Statistically significant difference was observed between the groups studied (p<0.05. Groups XT and SEP showed the highest bond strength values, without statistical difference between them, while group XT/Er:YAG showed reduction in bond strength values. Higher frequency of adhesive failures between enamel and adhesive system was verified for groups XT and XT/Er:YAG.Conclusion: The conventional (XT and self-etching (SEP adhesive systems showed mean bond

Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid-induced insulin resistance.

Science.gov (United States)

Shinjo, Satoko; Jiang, Shuying; Nameta, Masaaki; Suzuki, Tomohiro; Kanai, Mai; Nomura, Yuta; Goda, Nobuhito

2017-10-01

The mitochondria-associated ER membrane (MAM) is a specialized subdomain of ER that physically connects with mitochondria. Although disruption of inter-organellar crosstalk via the MAM impairs cellular homeostasis, its pathological significance in insulin resistance in type 2 diabetes mellitus remains unclear. Here, we reveal the importance of reduced MAM formation in the induction of fatty acid-evoked insulin resistance in hepatocytes. Palmitic acid (PA) repressed insulin-stimulated Akt phosphorylation in HepG2 cells within 12h. Treatment with an inhibitor of the ER stress response failed to restore PA-mediated suppression of Akt activation. Mitochondrial reactive oxygen species (ROS) production did not increase in PA-treated cells. Even short-term exposure (3h) to PA reduced the calcium flux from ER to mitochondria, followed by a significant decrease in MAM contact area, suggesting that PA suppressed the functional interaction between ER and mitochondria. Forced expression of mitofusin-2, a critical component of the MAM, partially restored MAM contact area and ameliorated the PA-elicited suppression of insulin sensitivity with Ser473 phosphorylation of Akt selectively improved. These results suggest that loss of proximity between ER and mitochondria, but not perturbation of homeostasis in the two organelles individually, plays crucial roles in PA-evoked Akt inactivation in hepatic insulin resistance. Copyright © 2017 Elsevier Inc. All rights reserved.

The observational approach in environmental restoration

International Nuclear Information System (INIS)

Smyth, J.D.; Quinn, R.D.

1991-07-01

The US Department of Energy (DOE) has committed to completing environmental restoration of its facilities within the next 28 years (DOE 1990b). In order to achieve this, DOE must ensure that its restoration activities are both effective and efficient. A key aspect of fulfilling this commitment is the recognition and management of uncertainty that is inherent in waste-site clean-up actions. The DOE Office of Environmental Restoration (DOE-ER) requested Pacific Northwest Laboratory (PNL) to investigate the applicability and implementation of what is known as the ''observational approach'' to better address these needs. PNL's initial investigation resulted in the positive conclusion that the observational approach had potential benefit to DOE during environmental restoration. In a follow-on effort, PNL supported by CH2M HILL, has been providing guidance to DOE field-offices on observational approach fundamentals, implementation, and application to waste-site remediation. This paper outlines the fundamentals of the observational approach and discusses the progress in integrating the observational approach in DOE's environmental restoration efforts. 9 refs., 2 figs

Completion Report for Well Cluster ER-6-1

Energy Technology Data Exchange (ETDEWEB)

Bechtel Nevada

2004-10-01

Well Cluster ER-6-1 was constructed for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Division at the Nevada Test Site, Nye County, Nevada. This work was initiated as part of the Groundwater Characterization Project, now known as the Underground Test Area Project. The well cluster is located in southeastern Yucca Flat. Detailed lithologic descriptions with stratigraphic assignments for Well Cluster ER-6-1 are included in this report. These are based on composite drill cuttings collected every 3 meters and conventional core samples taken below 639 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 11 samples to resolve complex interrelationships between several of the Tertiary tuff units. Additionally, paleontological analyses by the U.S. Geological Survey confirmed the stratigraphic assignments below 539 meters within the Paleozoic sedimentary section. All three wells in the Well ER-6-1 cluster were drilled within the Quaternary and Tertiary alluvium section, the Tertiary volcanic section, and into the Paleozoic sedimentary section.

Bioassay criteria for environmental restoration workers

International Nuclear Information System (INIS)

Carbaugh, E.H.; Bihl, D.E.

1993-01-01

Environmental restoration (ER) work at the U. S. Department of Energy Hanford Site posed questions concerning when to perform bioassay monitoring of workers for potential intakes of radioactivity. Application of criteria originally developed for use inside radionuclide processing facilities to ER work resulted in overly restrictive bioassay requirements. ER work typically involves site characterization or, excavating large quantities of potentially contaminated soil, rather than working with concentrated quantities of radioactivity as in a processing facility. An improved approach, tailored to ER work, provided soil contamination concentrations above which worker bioassay would be required. Soil concentrations were derived assuming acute or chronic intakes of 2% of an Annual Limit on Intake (ALI), or a potential committed effective dose equivalent of 100 mrem, and conservative dust loading of air from the work. When planning ER work, the anticipated soil concentration and corresponding need for bioassay could be estimated from work-site historical records. Once site work commenced, soil sampling and work-place surveys could be used to determine bioassay needs. This approach substantially reduced the required number of bioassay samples with corresponding reductions in analytical costs, schedules, and more flexible work-force management. (Work supported by the US Department of Energy under contract DOE-AC06-76RLO 1830.)

Transmission of Er:YAG laser through different dental ceramics.

Science.gov (United States)

Sari, Tugrul; Tuncel, Ilkin; Usumez, Aslihan; Gutknecht, Norbert

2014-01-01

The aim of this study was to determine the erbium-doped yttrium aluminum garnet (Er:YAG) laser transmission ratio through different dental ceramics with different thicknesses. Laser debonding procedure of adhesively luted all-ceramic restorations is based on the transmission of laser energy through the ceramic and the ablation of resin cement, because of the transmitted laser energy. Five different dental ceramics were evaluated in this study: sintered zirconium-oxide core ceramic, monolithic zirconium-oxide ceramic, feldspathic ceramic, leucite-reinforced glass ceramic, and lithium disilicate-reinforced glass ceramic. Two ceramic discs with different thicknesses (0.5 and 1 mm) were fabricated for each group. Ceramic discs were placed between the sensor membrane of the laser power meter and the tip of the contact handpiece of an Er:YAG laser device with the aid of a custom- made acrylic holder. The transmission ratio of Er:YAG laser energy (500 mJ, 2 Hz, 1 W, 1000 μs) through different ceramic discs was measured with the power meter. Ten measurements were made for each group and the results were analyzed with two way analysis of variance (ANOVA) and Tukey honestly significant difference (HSD) tests. The highest transmission ratio was determined for lithium disilicate-reinforced ceramic with 0.5 mm thickness (88%) and the lowest was determined for feldspathic ceramic with 1 mm thickness (44%). The differences among the different ceramics and between the different thicknesses were significant (pCeramic type and thickness should be taken into consideration to adjust the laser irradiation parameters during laser debonding of adhesively luted all-ceramic restorations.

Bearing restoration by grinding

Science.gov (United States)

Hanau, H.; Parker, R. J.; Zaretsky, E. V.; Chen, S. M.; Bull, H. L.

1976-01-01

A joint program was undertaken by the NASA Lewis Research Center and the Army Aviation Systems Command to restore by grinding those rolling-element bearings which are currently being discarded at aircraft engine and transmission overhaul. Three bearing types were selected from the UH-1 helicopter engine (T-53) and transmission for the pilot program. No bearing failures occurred related to the restoration by grinding process. The risk and cost of a bearing restoration by grinding programs was analyzed. A microeconomic impact analysis was performed.

Portsmouth Gaseous Diffusion Plant Decontamination and Decommissioning Program surveillance and maintenance plan, FY 1993--2002

International Nuclear Information System (INIS)

Schloesslin, W.

1992-11-01

The Decontamination and Decommissioning (D ampersand D) Program at the Portsmouth Gaseous Diffusion Plant (PORTS) is part of the Environmental Restoration (ER) and Waste Management (WM) Programs (ERWM). The objective of the ER Program is to provide PORTS the capability to meet applicable environmental regulations through facility development activities and site remedial actions. The WM Program supports the ER Program. The D ampersand D Program provides collective management of the sites within the plant which require decontamination and decommissioning, prioritizes those areas in terms of health, safety and environmental concerns, and implements the appropriate level of remedial action. The D ampersand D Program provides support to facilities which formerly served one or more of the many Plant functions. Program activities include (1) surveillance and maintenance of facilities awaiting decommissioning; (2) planning safe and orderly facility decommissioning; and (3) implementing a program to accomplish facility disposition in a safe, cost effective, and timely manner. In order to achieve the first objective, a formal plan which documents the surveillance and maintenance needs for each inactive facility has been prepared. This report provides this documentation for the PORTS facilities currently included in the D ampersand D Program and includes projected resource requirements for the planning period of FY 1993 through FY 2002

Lower Columbia River and Estuary Ecosystem Restoration Program Reference Site Study: 2011 Restoration Analysis - FINAL REPORT

Energy Technology Data Exchange (ETDEWEB)

Borde, Amy B.; Cullinan, Valerie I.; Diefenderfer, Heida L.; Thom, Ronald M.; Kaufmann, Ronald M.; Zimmerman, Shon A.; Sagar, Jina; Buenau, Kate E.; Corbett, C.

2012-05-31

The Reference Site (RS) study is part of the research, monitoring, and evaluation (RME) effort developed by the Action Agencies (Bonneville Power Administration [BPA], U.S. Army Corps of Engineers, Portland District [USACE], and U.S. Bureau of Reclamation) in response to Federal Columbia River Power System (FCRPS) Biological Opinions (BiOp). While the RS study was initiated in 2007, data have been collected at relatively undisturbed reference wetland sites in the LCRE by PNNL and collaborators since 2005. These data on habitat structural metrics were previously summarized to provide baseline characterization of 51 wetlands throughout the estuarine and tidal freshwater portions of the 235-km LCRE; however, further analysis of these data has been limited. Therefore, in 2011, we conducted additional analyses of existing field data previously collected for the Columbia Estuary Ecosystem Restoration Program (CEERP) - including data collected by PNNL and others - to help inform the multi-agency restoration planning and ecosystem management work underway in the LCRE.

Assessment of interim flow water-quality data of the San Joaquin River restoration program and implications for fishes, California, 2009-11

Science.gov (United States)

Wulff, Marissa L.; Brown, Larry R.

2015-01-01

After more than 50 years of extensive water diversion for urban and agriculture use, a major settlement was reached among the U.S. Departments of the Interior and Commerce, the Natural Resources Defense Council, and the Friant Water Users Authority in an effort to restore the San Joaquin River. The settlement received Federal court approval in October 2006 and established the San Joaquin River Restoration Program, a multi-agency collaboration between State and Federal agencies to restore and maintain fish populations, including Chinook salmon, in the main stem of the river between Friant Dam and the confluence with the Merced River. This is to be done while avoiding or minimizing adverse water supply effects to all of the Friant Division contractors that could result from restoration flows required by the settlement. The settlement stipulates that water- and sediment-quality data be collected to help assess the restoration goals. This report summarizes and evaluates water-quality data collected in the main stem of the San Joaquin River between Friant Dam and the Merced River by the U.S. Bureau of Reclamation for the San Joaquin River Restoration Program during 2009-11. This summary and assessment consider sampling frequency for adequate characterization of variability, sampling locations for sufficient characterization of the San Joaquin River Restoration Program restoration reach, sampling methods for appropriate media (water and sediment), and constituent reporting limits. After reviewing the water- and sediment-quality results for the San Joaquin River Restoration Program, several suggestions were made to the Fisheries Management Work Group, a division of the San Joaquin River Restoration Program that focuses solely on the reintroduction strategies and health of salmon and other native fishes in the river. Water-quality results for lead and total organic carbon exceeded the Surface Water Ambient Monitoring Program Basin Plan Objectives for the San Joaquin Basin

Visions of Restoration in Fire-Adapted Forest Landscapes: Lessons from the Collaborative Forest Landscape Restoration Program

Science.gov (United States)

Urgenson, Lauren S.; Ryan, Clare M.; Halpern, Charles B.; Bakker, Jonathan D.; Belote, R. Travis; Franklin, Jerry F.; Haugo, Ryan D.; Nelson, Cara R.; Waltz, Amy E. M.

2017-02-01

Collaborative approaches to natural resource management are becoming increasingly common on public lands. Negotiating a shared vision for desired conditions is a fundamental task of collaboration and serves as a foundation for developing management objectives and monitoring strategies. We explore the complex socio-ecological processes involved in developing a shared vision for collaborative restoration of fire-adapted forest landscapes. To understand participant perspectives and experiences, we analyzed interviews with 86 respondents from six collaboratives in the western U.S., part of the Collaborative Forest Landscape Restoration Program established to encourage collaborative, science-based restoration on U.S. Forest Service lands. Although forest landscapes and group characteristics vary considerably, collaboratives faced common challenges to developing a shared vision for desired conditions. Three broad categories of challenges emerged: meeting multiple objectives, collaborative capacity and trust, and integrating ecological science and social values in decision-making. Collaborative groups also used common strategies to address these challenges, including some that addressed multiple challenges. These included use of issue-based recommendations, field visits, and landscape-level analysis; obtaining support from local agency leadership, engaging facilitators, and working in smaller groups (sub-groups); and science engagement. Increased understanding of the challenges to, and strategies for, developing a shared vision of desired conditions is critical if other collaboratives are to learn from these efforts.

Visions of Restoration in Fire-Adapted Forest Landscapes: Lessons from the Collaborative Forest Landscape Restoration Program.

Science.gov (United States)

Urgenson, Lauren S; Ryan, Clare M; Halpern, Charles B; Bakker, Jonathan D; Belote, R Travis; Franklin, Jerry F; Haugo, Ryan D; Nelson, Cara R; Waltz, Amy E M

2017-02-01

Collaborative approaches to natural resource management are becoming increasingly common on public lands. Negotiating a shared vision for desired conditions is a fundamental task of collaboration and serves as a foundation for developing management objectives and monitoring strategies. We explore the complex socio-ecological processes involved in developing a shared vision for collaborative restoration of fire-adapted forest landscapes. To understand participant perspectives and experiences, we analyzed interviews with 86 respondents from six collaboratives in the western U.S., part of the Collaborative Forest Landscape Restoration Program established to encourage collaborative, science-based restoration on U.S. Forest Service lands. Although forest landscapes and group characteristics vary considerably, collaboratives faced common challenges to developing a shared vision for desired conditions. Three broad categories of challenges emerged: meeting multiple objectives, collaborative capacity and trust, and integrating ecological science and social values in decision-making. Collaborative groups also used common strategies to address these challenges, including some that addressed multiple challenges. These included use of issue-based recommendations, field visits, and landscape-level analysis; obtaining support from local agency leadership, engaging facilitators, and working in smaller groups (sub-groups); and science engagement. Increased understanding of the challenges to, and strategies for, developing a shared vision of desired conditions is critical if other collaboratives are to learn from these efforts.

Completion Report for Well ER-20-4 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Management

2011-04-30

Well ER-20-4 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site, Nye County, Nevada. The well was drilled in August and September 2010 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to investigate the possibility of radionuclide transport from up-gradient underground nuclear tests conducted in central Pahute Mesa. This well also provided detailed hydrogeologic information in the Tertiary volcanic section that will help reduce uncertainties within the Pahute Mesa-Oasis Valley hydrostratigraphic framework model.

200 Areas soil remediation strategy -- Environmental Restoration Program

International Nuclear Information System (INIS)

1996-09-01

The remediation and waste management activities in the 200 Areas of the Hanford Site (located in Richland, Washington) currently range from remediating groundwater, remediating source units (contaminated soils), decontaminating and decommissioning of buildings and structures, maintaining facilities, managing transuranic, low-level and mixed waste, and operating tank farms that store high-level waste. This strategy focuses on the assessment and remediation of soil that resulted from the discharge of liquids and solids from processing facilities to the ground (e.g., ponds, ditches, cribs, burial grounds) in the 200 Areas and addresses only those waste sites assigned to the Environmental Restoration Program

Nuclear facility decommissioning and site remedial actions: A selected bibliography, Volume 13: Part 1, Main text. Environmental Restoration Program

Energy Technology Data Exchange (ETDEWEB)

Goins, L.F.; Webb, J.R.; Cravens, C.D.; Mallory, P.K.

1992-09-01

This publication contains 1035 abstracted references on environmental restoration, nuclear facility decommissioning, uranium mill tailings management, and site remedial actions. These citations constitute the thirteenth in a series of reports prepared annually for the US Department of Energy (DOE) Environmental Restoration programs. Citations to foreign and domestic literature of all types. There are 13 major sections of the publication, including: (1) DOE Decontamination and Decommissioning Program; (2) Nuclear Facilities Decommissioning; (3) DOE Formerly Utilized Sites Remedial Action Program; (4) DOE Uranium Mill Tailings Remedial Action Project; (5) Uranium Mill Tailings Management; (6) DOE Environmental Restoration Program; (7) DOE Site-Specific Remedial Actions; (8) Contaminated Site Restoration; (9) Remediation of Contaminated Soil and Groundwater; (10) Environmental Data Measurements, Management, and Evaluation; (11) Remedial Action Assessment and Decision-Making; (12) Technology Development and Evaluation; and (13) Environmental and Waste Management Issues. Bibliographic references are arranged in nine subject categories by geographic location and then alphabetically by first author, corporate affiliation, or publication title. Indexes are provided for author, corporate affiliation, title word, publication description, geographic location, subject category, and key word.

Native plant development and restoration program for the Great Basin, USA

Science.gov (United States)

N. L. Shaw; M. Pellant; P. Olweli; S. L. Jensen; E. D. McArthur

2008-01-01

The Great Basin Native Plant Selection and Increase Project, organized by the USDA Bureau of Land Management, Great Basin Restoration Initiative and the USDA Forest Service, Rocky Mountain Research Station in 2000 as a multi-agency collaborative program (http://www.fs.fed.us/rm/boise/research/shrub/greatbasin.shtml), has the objective of improving the availability of...

Environmental Restoration Operations: Consolidated Quarterly Report January -March 2017

Energy Technology Data Exchange (ETDEWEB)

Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-07-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented at Sandia National Laboratories, New Mexico (SNL/NM) during the January, February, and March 2017 quarterly reporting period. Table I-1 lists the Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM. Sections I.2.1 and I.2.2 summarize the work completed during this quarter. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities. Field activities are conducted at the three groundwater AOCs (Burn Site Groundwater [BSG AOC], Technical Area [TA]-V Groundwater [TAVG AOC], and Tijeras Arroyo Groundwater [TAG AOC]). Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) Hazardous Waste Bureau (HWB) issued a certificate of completion and the sites are in the corrective action complete (CAC) regulatory process. Currently, SWMUs 8 and 58, 68, 149, 154, and 502 are in the CAC regulatory process. Corrective action activities are deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these three sites are active mission facilities. These three active mission sites are located in TA-III. This Sandia National Laboratories, New Mexico Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) fulfills all quarterly reporting requirements set forth in the Resource Conservation and Recovery Act Facility Operating Permit and the Compliance Order on Consent.

Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation

Directory of Open Access Journals (Sweden)

Francisco Westermeier

2014-01-01

Full Text Available The global epidemics of obesity during pregnancy and excessive gestational weight gain (GWG are major public health problems worldwide. Obesity and excessive GWG are related to several maternal and fetal complications, including diabetes (pregestational and gestational diabetes and intrauterine programming of insulin resistance (IR. Maternal obesity (MO and neonatal IR are associated with long-term development of obesity, diabetes mellitus, and increased global cardiovascular risk in the offspring. Multiple mechanisms of insulin signaling pathway impairment have been described in obese individuals, involving complex interactions of chronically elevated inflammatory mediators, adipokines, and the critical role of the endoplasmic reticulum (ER stress-dependent unfolded protein response (UPR. However, the underlying cellular processes linking MO and IR in the offspring have not been fully elucidated. Here, we summarize the state-of-the-art evidence supporting the possibility that adverse metabolic postnatal outcomes such as IR in the offspring of pregnancies with MO and/or excessive GWG may be related to intrauterine activation of ER stress response.

Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation

Science.gov (United States)

Sáez, Pablo J.; Villalobos-Labra, Roberto; Farías-Jofré, Marcelo

2014-01-01

The global epidemics of obesity during pregnancy and excessive gestational weight gain (GWG) are major public health problems worldwide. Obesity and excessive GWG are related to several maternal and fetal complications, including diabetes (pregestational and gestational diabetes) and intrauterine programming of insulin resistance (IR). Maternal obesity (MO) and neonatal IR are associated with long-term development of obesity, diabetes mellitus, and increased global cardiovascular risk in the offspring. Multiple mechanisms of insulin signaling pathway impairment have been described in obese individuals, involving complex interactions of chronically elevated inflammatory mediators, adipokines, and the critical role of the endoplasmic reticulum (ER) stress-dependent unfolded protein response (UPR). However, the underlying cellular processes linking MO and IR in the offspring have not been fully elucidated. Here, we summarize the state-of-the-art evidence supporting the possibility that adverse metabolic postnatal outcomes such as IR in the offspring of pregnancies with MO and/or excessive GWG may be related to intrauterine activation of ER stress response. PMID:25093191

Educational understanding of pollution prevention in decontamination and decommissioning/environmental restoration activities

International Nuclear Information System (INIS)

Betsch, M.D.; Lewis, R.A.

1995-05-01

Demolishing outdated structures from the US Department of Energy Hanford Site in Washington, generates large quantities of waste which can be minimized. The Hanford cleanup is one of the world's largest and most complex environmental restoration efforts. Approximately 280 square miles of ground water and soil are contaminated; there are more than 80 surplus facilities, including nine shut-down nuclear reactors in various stages of decay; and there are 177 underground waste storage tanks containing highly radioactive waste. In all, 1,500 cleanup sites have been identified and the Environmental Restoration Contractor (ERC) is currently responsible for surveillance and maintenance of 170 structures. A two hour orientation training in pollution prevention was developed by the Westinghouse Hanford Company to provide all Decontamination and Decommissioning/Environmental Restoration (D ampersand D/ER) personnel with the knowledge to apply waste minimization principles during their cleanup activities. The ERC Team Pollution Prevention Workshop serves to communicate pollution prevention philosophies and influences the way D ampersand D/ER projects are conducted at the Hanford Site

Community Relations Plan for Lawrence Berkeley Laboratory. Environmental Restoration Program

Energy Technology Data Exchange (ETDEWEB)

1993-07-01

The Lawrence Berkeley Laboratory (LBL) has applied to the California Environmental Protection Agency, Department of Toxic Substances Control (DTSC), for renewal of its Hazardous Waste Handling Facility Permit. A permit is required under Resource Conservation and Recovery Act (RCRA) regulations. The permit will allow LBL to continue using its current hazardous waste handling facility, upgrade the existing facility, and construct a replacement facility. The new facility is scheduled for completion in 1995. The existing facility will be closed under RCRA guidelines by 1996. As part of the permitting process, LBL is required to investigate areas of soil and groundwater contamination at its main site in the Berkeley Hills. The investigations are being conducted by LBL`s Environmental Restoration Program and are overseen by a number of regulatory agencies. The regulatory agencies working with LBL include the California Environmental Protection Agency`s Department of Toxic Substances Control, the California Regional Water Quality Control Board, the Bay Area Air Quality Management District, the East Bay Municipal Utilities District, and the Berkeley Department of Environmental Health. RCRA requires that the public be informed of LBL`s investigations and site cleanup, and that opportunities be available for the public to participate in making decisions about how LBL will address contamination issues. LBL has prepared this Community Relations Plan (CRP) to describe activities that LBL will use to keep the community informed of environmental restoration progress and to provide for an open dialogue with the public on issues of importance. The CRP documents the community`s current concerns about LBL`s Environmental Restoration Program. Interviews conducted between February and April 1993 with elected officials, agency staff, environmental organizations, businesses, site neighbors, and LBL employees form the basis for the information contained in this document.

Effectiveness of a lifestyle exercise program for older people receiving a restorative home care service: a pragmatic randomized controlled trial.

Science.gov (United States)

Burton, Elissa; Lewin, Gill; Clemson, Lindy; Boldy, Duncan

2013-01-01

Restorative home care services are short-term and aimed at maximizing a person's ability to live independently. They are multidimensional and often include an exercise program to improve strength, mobility, and balance. The aim of this study was to determine whether a lifestyle exercise program would be undertaken more often and result in greater functional gains than the current structured exercise program delivered as part of a restorative home care service for older adults. A pragmatic randomized controlled trial was conducted in an organization with an established restorative home care service. Individuals who were to have an exercise program as part of their service were randomized to receive either a lifestyle and functional exercise program called LiFE (as this was a new program, the intervention) or the structured exercise program currently being used in the service (control). Exercise data collected by the individuals throughout and pre and post intervention testing was used to measure balance, strength, mobility, falls efficacy, vitality, function, and disability. There was no difference between the groups in the amounts of exercise undertaken during the 8-week intervention period. Outcome measurement indicated that the LiFE program was as effective, and on 40% of the measures, more effective, than the structured exercise program. Organizations delivering restorative home care services that include an exercise component should consider whether LiFE rather than the exercise program they are currently using could help their clients achieve better outcomes.

Energy Security and Restoration Exercise Program/Best Practices and Information Sharing

Energy Technology Data Exchange (ETDEWEB)

Barbara McCabe; John Kovach

2009-03-30

The first year of this cooperative agreement focused on the following elements: curriculum development and presentation, curriculum maintenance, enhancements, and effectiveness, and smart card initiative. During the second year of this grant, with redirection from DOE, the IUOE modified its mission statement under the cooperative agreement. It states: 'The mission of the IUOE is to provide expertise to provide best practices, information sharing, and develop scenarios and conduct exercises ranging in size and complexity from table top to national level to prepare all stakeholders to protect and restore energy infrastructure should an event, terrorist or natural, occur'. The Program developed a number of products under this Cooperative Agreement. These products include: FOSTER (Facility Operations Safety Training Event Response) Curriculum and Training Models, Alternative Energy Supply - Generators Training Module, Liquefied Natural Gas Training Module, Education Program - Distributed Generations, Compendium of Resources and References, Energy Security and Restoration Training Manual, Manual of Situations and Scenarios Developed for Emergency Exercises, Manual of Best Practices/Lessons Learned for Energy Load Management, Training Plan, Strategic Information and Exercise Plan, National Certification Plan Report, and a Smart Card Project Report.

Flow Restoration in the Columbia River Basin: An Evaluation of a Flow Restoration Accounting Framework.

Science.gov (United States)

McCoy, Amy L; Holmes, S Rankin; Boisjolie, Brett A

2018-03-01

Securing environmental flows in support of freshwater biodiversity is an evolving field of practice. An example of a large-scale program dedicated to restoring environmental flows is the Columbia Basin Water Transactions Program in the Pacific Northwest region of North America, which has been restoring flows in dewatered tributary habitats for imperiled salmon species over the past decade. This paper discusses a four-tiered flow restoration accounting framework for tracking the implementation and impacts of water transactions as an effective tool for adaptive management. The flow restoration accounting framework provides compliance and flow accounting information to monitor transaction efficacy. We review the implementation of the flow restoration accounting framework monitoring framework to demonstrate (a) the extent of water transactions that have been implemented over the past decade, (b) the volumes of restored flow in meeting flow targets for restoring habitat for anadromous fish species, and (c) an example of aquatic habitat enhancement that resulted from Columbia Basin Water Transactions Program investments. Project results show that from 2002 to 2015, the Columbia Basin Water Transactions Program has completed more than 450 water rights transactions, restoring approximately 1.59 million megaliters to date, with an additional 10.98 million megaliters of flow protected for use over the next 100 years. This has resulted in the watering of over 2414 stream kilometers within the Columbia Basin. We conclude with a discussion of the insights gained through the implementation of the flow restoration accounting framework. Understanding the approach and efficacy of a monitoring framework applied across a large river basin can be informative to emerging flow-restoration and adaptive management efforts in areas of conservation concern.

Flow Restoration in the Columbia River Basin: An Evaluation of a Flow Restoration Accounting Framework

Science.gov (United States)

McCoy, Amy L.; Holmes, S. Rankin; Boisjolie, Brett A.

2018-03-01

Securing environmental flows in support of freshwater biodiversity is an evolving field of practice. An example of a large-scale program dedicated to restoring environmental flows is the Columbia Basin Water Transactions Program in the Pacific Northwest region of North America, which has been restoring flows in dewatered tributary habitats for imperiled salmon species over the past decade. This paper discusses a four-tiered flow restoration accounting framework for tracking the implementation and impacts of water transactions as an effective tool for adaptive management. The flow restoration accounting framework provides compliance and flow accounting information to monitor transaction efficacy. We review the implementation of the flow restoration accounting framework monitoring framework to demonstrate (a) the extent of water transactions that have been implemented over the past decade, (b) the volumes of restored flow in meeting flow targets for restoring habitat for anadromous fish species, and (c) an example of aquatic habitat enhancement that resulted from Columbia Basin Water Transactions Program investments. Project results show that from 2002 to 2015, the Columbia Basin Water Transactions Program has completed more than 450 water rights transactions, restoring approximately 1.59 million megaliters to date, with an additional 10.98 million megaliters of flow protected for use over the next 100 years. This has resulted in the watering of over 2414 stream kilometers within the Columbia Basin. We conclude with a discussion of the insights gained through the implementation of the flow restoration accounting framework. Understanding the approach and efficacy of a monitoring framework applied across a large river basin can be informative to emerging flow-restoration and adaptive management efforts in areas of conservation concern.

50 CFR 80.25 - Multiyear financing under the Dingell-Johnson Sport Fish Restoration Program.

Science.gov (United States)

2010-10-01

...-Johnson Sport Fish Restoration Act in two ways: (1) States may finance the entire cost of the acquisition... Program. (a) States may finance the acquisition of lands or interests in lands including water rights and...

Diverse characteristics of wetlands restored under the Wetlands Reserve Program in the Southeastern United States

Science.gov (United States)

Diane De Steven; Joel M. Gramling

2012-01-01

The Wetlands Reserve Program (WRP) restores converted or degraded wetlands on private working lands; however, the nature and outcomes of such efforts are undocumented in the Southeastern U.S. Identification of wetland types is needed to assess the program's conservation benefits, because ecological functions differ with hydrogeomorphic (HGM) type. We reviewed...

Purple perilla extracts allay ER stress in lipid-laden macrophages.

Directory of Open Access Journals (Sweden)

Sin-Hye Park

Full Text Available There is a growing body of evidence that excess lipids, hypoxic stress and other inflammatory signals can stimulate endoplasmic reticulum (ER stress in metabolic diseases. However, the pathophysiological importance and the underlying mechanisms of this phenomenon remain unknown. The current study investigated that 50 ng/ml oxidized LDL promoted unfolded protein response (UPR and ER stress in J774A1 murine macrophages, which was blocked by extracts (PPE of purple Perilla frutescens, a plant of the mint family Lamiaceae. The ER stressor tunicamycin was employed as a positive control. Treating 1-10 µg/ml oxidized LDL for 24 h elicited lipotoxic apoptosis in macrophages with obvious nuclear condensation and DNA fragmentation, which was inhibited by PPE. Tunicamycin and oxidized LDL activated and induced the UPR components of activating transcription factor 6 and ER resident chaperone BiP/Grp78 in temporal manners and such effects were blocked by ≥5 µg/ml PPE. In addition, PPE suppressed the enhanced mRNA transcription and splicing of X-box binding protein 1 (XBP1 by tunicamycin and oxidized LDL. The protein induction and nuclear translocation of XBP1 were deterred in PPE-treated macrophages under ER stress. The induction of ATP-binding cassette transporter A1 (ABCA1, scavenger receptor-B1 (SR-B1 and intracellular adhesion molecule-1 (ICAM-1 was abolished by the ER stressor in activated macrophages. The protein induction of ABCA1 and ICAM1 but not SR-B1 was retrieved by adding 10 µg/ml PPE to cells. These results demonstrate that PPE inhibited lipotoxic apoptosis and demoted the induction and activation of UPR components in macrophages. PPE restored normal proteostasis in activated macrophages oxidized LDL. Therefore, PPE was a potent agent antagonizing macrophage ER stress due to lipotoxic signals associated with atherosclerosis.

Completion Report for Well ER-EC-1

International Nuclear Information System (INIS)

Townsend, M.J.

2000-01-01

Well ER-EC-1 was drilled for the U.S. Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the spring of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to the depth 675.1 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,524.0 meters. A preliminary composite, static, water level was measured at the depth of approximately 566.3 meters prior to installation of the completion string. One completion string with three isolated, slotted intervals was installed in the well. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters and 31 sidewall samples taken at various depths below 680 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well penetrated Tertiary-age lava and tuff of the Timber Mountain Group, the Paintbrush Group, the Calico Hills Formation, the Crater Flat Group, and the Volcanics of Quartz Mountain. The preliminary geologic interpretation of data from Well ER-EC-1 indicates the presence of a structural trough or bench filled with a thick section of post-Rainier Mesa lava. These data also suggest that this site is located on a buried structural ridge that may separate the Silent Canyon and Timber Mountain caldera complexes

Thermodynamic assessments of the Ag-Er and Er-Y systems

International Nuclear Information System (INIS)

Wang, S.L.; Wang, C.P.; Liu, X.J.; Tang, A.T.; Pan, F.S.; Ishida, K.

2010-01-01

The phase diagrams and thermodynamic properties in the Ag-Er and Er-Y binary systems have been assessed by using the CALPHAD (Calculation of Phase Diagrams) method on the basis of the experimental data including the thermodynamic properties and phase equilibria. The Gibbs free energies of the liquid, bcc, fcc, and hcp phases were described by the subregular solution model with the Redlich-Kister equation, and those of intermetallic compounds (Ag 2 Er and AgEr phases) were treated as stoichiometric compounds, and Ag 51 Er 14 phase was modeled by the sublattice model in the Ag-Er binary system. The thermodynamic parameters of the Ag-Er and Er-Y binary systems were obtained, and an agreement between the calculated results and experimental data was obtained for each binary system.

Environmental restoration and statistics: Issues and needs

International Nuclear Information System (INIS)

Gilbert, R.O.

1991-10-01

Statisticians have a vital role to play in environmental restoration (ER) activities. One facet of that role is to point out where additional work is needed to develop statistical sampling plans and data analyses that meet the needs of ER. This paper is an attempt to show where statistics fits into the ER process. The statistician, as member of the ER planning team, works collaboratively with the team to develop the site characterization sampling design, so that data of the quality and quantity required by the specified data quality objectives (DQOs) are obtained. At the same time, the statistician works with the rest of the planning team to design and implement, when appropriate, the observational approach to streamline the ER process and reduce costs. The statistician will also provide the expertise needed to select or develop appropriate tools for statistical analysis that are suited for problems that are common to waste-site data. These data problems include highly heterogeneous waste forms, large variability in concentrations over space, correlated data, data that do not have a normal (Gaussian) distribution, and measurements below detection limits. Other problems include environmental transport and risk models that yield highly uncertain predictions, and the need to effectively communicate to the public highly technical information, such as sampling plans, site characterization data, statistical analysis results, and risk estimates. Even though some statistical analysis methods are available ''off the shelf'' for use in ER, these problems require the development of additional statistical tools, as discussed in this paper. 29 refs

Spliced leader RNA silencing (SLS - a programmed cell death pathway in Trypanosoma brucei that is induced upon ER stress

Directory of Open Access Journals (Sweden)

Michaeli Shulamit

2012-05-01

Full Text Available Abstract Trypanosoma brucei is the causative agent of African sleeping sickness. The parasite cycles between its insect (procyclic form and mammalian hosts (bloodstream form. Trypanosomes lack conventional transcription regulation, and their genes are transcribed in polycistronic units that are processed by trans-splicing and polyadenylation. In trans-splicing, which is essential for processing of each mRNA, an exon, the spliced leader (SL is added to all mRNAs from a small RNA, the SL RNA. Trypanosomes lack the machinery for the unfolded protein response (UPR, which in other eukaryotes is induced under endoplasmic reticulum (ER stress. Trypanosomes respond to such stress by changing the stability of mRNAs, which are essential for coping with the stress. However, under severe ER stress that is induced by blocking translocation of proteins to the ER, treatment of cells with chemicals that induce misfolding in the ER, or extreme pH, trypanosomes elicit the spliced leader silencing (SLS pathway. In SLS, the transcription of the SL RNA gene is extinguished, and tSNAP42, a specific SL RNA transcription factor, fails to bind to its cognate promoter. SLS leads to complete shut-off of trans-splicing. In this review, I discuss the UPR in mammals and compare it to the ER stress response in T. brucei leading to SLS. I summarize the evidence supporting the notion that SLS is a programmed cell death (PCD pathway that is utilized by the parasites to substitute for the apoptosis observed in higher eukaryotes under prolonged ER stress. I present the hypothesis that SLS evolved to expedite the death process, and rapidly remove from the population unfit parasites that, by elimination via SLS, cause minimal damage to the parasite population.

Low Estrogen Receptor (ER)-Positive Breast Cancer and Neoadjuvant Systemic Chemotherapy: Is Response Similar to Typical ER-Positive or ER-Negative Disease?

Science.gov (United States)

Landmann, Alessandra; Farrugia, Daniel J; Zhu, Li; Diego, Emilia J; Johnson, Ronald R; Soran, Atilla; Dabbs, David J; Clark, Beth Z; Puhalla, Shannon L; Jankowitz, Rachel C; Brufsky, Adam M; Ahrendt, Gretchen M; McAuliffe, Priscilla F; Bhargava, Rohit

2018-05-08

Pathologic complete response (pCR) rate after neoadjuvant chemotherapy was compared between 141 estrogen receptor (ER)-negative (43%), 41 low ER+ (13%), 47 moderate ER+ (14%), and 98 high ER+ (30%) tumors. Human epidermal growth factor receptor 2-positive cases, cases without semiquantitative ER score, and patients treated with neoadjuvant endocrine therapy alone were excluded. The pCR rate of low ER+ tumors was similar to the pCR rate of ER- tumors (37% and 26% for low ER and ER- respectively, P = .1722) but significantly different from the pCR rate of moderately ER+ (11%, P = .0049) and high ER+ tumors (4%, P < .0001). Patients with pCR had an excellent prognosis regardless of the ER status. In patients with residual disease (no pCR), the recurrence and death rate were higher in ER- and low ER+ cases compared with moderate and high ER+ cases. Low ER+ breast cancers are biologically similar to ER- tumors. Semiquantitative ER H-score is an important determinant of response to neoadjuvant chemotherapy.

Effectiveness of a lifestyle exercise program for older people receiving a restorative home care service: a pragmatic randomized controlled trial

Directory of Open Access Journals (Sweden)

Burton E

2013-12-01

Full Text Available Elissa Burton,1,2 Gill Lewin,1,2 Lindy Clemson,3 Duncan Boldy41Faculty of Health Sciences, Curtin University, Perth, WA, Australia; 2Research Department, Silver Chain, Perth, WA, Australia; 3Health and Work Research Unit, The University of Sydney, Sydney, NSW, Australia; 4School of Nursing and Midwifery, Curtin University, Perth, WA, AustraliaBackground: Restorative home care services are short-term and aimed at maximizing a person’s ability to live independently. They are multidimensional and often include an exercise program to improve strength, mobility, and balance. The aim of this study was to determine whether a lifestyle exercise program would be undertaken more often and result in greater functional gains than the current structured exercise program delivered as part of a restorative home care service for older adults.Methods: A pragmatic randomized controlled trial was conducted in an organization with an established restorative home care service. Individuals who were to have an exercise program as part of their service were randomized to receive either a lifestyle and functional exercise program called LiFE (as this was a new program, the intervention or the structured exercise program currently being used in the service (control. Exercise data collected by the individuals throughout and pre and post intervention testing was used to measure balance, strength, mobility, falls efficacy, vitality, function, and disability.Results: There was no difference between the groups in the amounts of exercise undertaken during the 8-week intervention period. Outcome measurement indicated that the LiFE program was as effective, and on 40% of the measures, more effective, than the structured exercise program.Conclusion: Organizations delivering restorative home care services that include an exercise component should consider whether LiFE rather than the exercise program they are currently using could help their clients achieve better outcomes

Talking Circles for Adolescent Girls in an Urban High School: A Restorative Practices Program for Building Friendships and Developing Emotional Literacy Skills

Science.gov (United States)

Schumacher, Martha Ann

2012-01-01

Restorative Practices and Restorative Justice programs in schools are a new and emerging field. Meeting in Circles to build community, resolve conflict, and learn interactively are core components of these programs. This ethnographic study, which took place February 2010 to December 2011, evaluates 12 small, out-of-classroom Talking Circles for 60…

β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.

Science.gov (United States)

Shang, Linshan; Hua, Haiqing; Foo, Kylie; Martinez, Hector; Watanabe, Kazuhisa; Zimmer, Matthew; Kahler, David J; Freeby, Matthew; Chung, Wendy; LeDuc, Charles; Goland, Robin; Leibel, Rudolph L; Egli, Dieter

2014-03-01

Wolfram syndrome is an autosomal recessive disorder caused by mutations in WFS1 and is characterized by insulin-dependent diabetes mellitus, optic atrophy, and deafness. To investigate the cause of β-cell failure, we used induced pluripotent stem cells to create insulin-producing cells from individuals with Wolfram syndrome. WFS1-deficient β-cells showed increased levels of endoplasmic reticulum (ER) stress molecules and decreased insulin content. Upon exposure to experimental ER stress, Wolfram β-cells showed impaired insulin processing and failed to increase insulin secretion in response to glucose and other secretagogues. Importantly, 4-phenyl butyric acid, a chemical protein folding and trafficking chaperone, restored normal insulin synthesis and the ability to upregulate insulin secretion. These studies show that ER stress plays a central role in β-cell failure in Wolfram syndrome and indicate that chemical chaperones might have therapeutic relevance under conditions of ER stress in Wolfram syndrome and other forms of diabetes.

System Safety Program Plan for Project W-314, tank farm restoration and safe operations

International Nuclear Information System (INIS)

Boos, K.A.

1996-01-01

This System Safety Program Plan (SSPP) outlines the safety analysis strategy for project W-314, ''Tank Farm Restoration and Safe Operations.'' Project W-314 will provide capital improvements to Hanford's existing Tank Farm facilities, with particular emphasis on infrastructure systems supporting safe operation of the double-shell activities related to the project's conceptual Design Phase, but is planned to be updated and maintained as a ''living document'' throughout the life of the project to reflect the current safety analysis planning for the Tank Farm Restoration and Safe Operations upgrades. This approved W-314 SSPP provides the basis for preparation/approval of all safety analysis documentation needed to support the project

Hvis en kartoffel er forkert, hvad er en Mars-bar så?

DEFF Research Database (Denmark)

Lichtenstein, Mia Beck; Thomsen, Freja; Hinze, Cecilie

2016-01-01

Danske unge er de slankeste af 41 europæiske unge, men de føler sig ofte tykke og går på slankekur. Hvad er årsagen, og hvorfor er det et problem?......Danske unge er de slankeste af 41 europæiske unge, men de føler sig ofte tykke og går på slankekur. Hvad er årsagen, og hvorfor er det et problem?...

ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology.

Science.gov (United States)

Manford, Andrew G; Stefan, Christopher J; Yuan, Helen L; Macgurn, Jason A; Emr, Scott D

2012-12-11

Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane. However, little is known about the mechanisms that tether these organelles together and why such connections are maintained. Using a quantitative proteomic approach, we identified three families of ER-PM tethering proteins in yeast: Ist2 (related to mammalian TMEM16 ion channels), the tricalbins (Tcb1/2/3, orthologs of the extended synaptotagmins), and Scs2 and Scs22 (vesicle-associated membrane protein-associated proteins). Loss of all six tethering proteins results in the separation of the ER from the PM and the accumulation of cytoplasmic ER. Importantly, we find that phosphoinositide signaling is misregulated at the PM, and the unfolded protein response is constitutively activated in the ER in cells lacking ER-PM tether proteins. These results reveal critical roles for ER-PM contacts in cell signaling, organelle morphology, and ER function. Copyright © 2012 Elsevier Inc. All rights reserved.

Idaho National Engineering Laboratory (INEL) Environmental Restoration Program (ERP), Baseline Safety Analysis File (BSAF). Revision 1

Energy Technology Data Exchange (ETDEWEB)

1994-06-20

This document was prepared to take the place of a Safety Evaluation Report since the Baseline Safety Analysis File (BSAF)and associated Baseline Technical Safety Requirements (TSR) File do not meet the requirements of a complete safety analysis documentation. Its purpose is to present in summary form the background of how the BSAF and Baseline TSR originated and a description of the process by which it was produced and approved for use in the Environmental Restoration Program.The BSAF is a facility safety reference document for INEL environmental restoration activities including environmental remediation of inactive waste sites and decontamination and decommissioning (D&D) of surplus facilities. The BSAF contains safety bases common to environmental restoration activities and guidelines for performing and documenting safety analysis. The common safety bases can be incorporated by reference into the safety analysis documentation prepared for individual environmental restoration activities with justification and any necessary revisions. The safety analysis guidelines in BSAF provide an accepted method for hazard analysis; analysis of normal, abnormal, and accident conditions; human factors analysis; and derivation of TSRS. The BSAF safety bases and guidelines are graded for environmental restoration activities.

Idaho National Engineering Laboratory (INEL) Environmental Restoration Program (ERP), Baseline Safety Analysis File (BSAF). Revision 1

International Nuclear Information System (INIS)

1994-01-01

This document was prepared to take the place of a Safety Evaluation Report since the Baseline Safety Analysis File (BSAF)and associated Baseline Technical Safety Requirements (TSR) File do not meet the requirements of a complete safety analysis documentation. Its purpose is to present in summary form the background of how the BSAF and Baseline TSR originated and a description of the process by which it was produced and approved for use in the Environmental Restoration Program.The BSAF is a facility safety reference document for INEL environmental restoration activities including environmental remediation of inactive waste sites and decontamination and decommissioning (D ampersand D) of surplus facilities. The BSAF contains safety bases common to environmental restoration activities and guidelines for performing and documenting safety analysis. The common safety bases can be incorporated by reference into the safety analysis documentation prepared for individual environmental restoration activities with justification and any necessary revisions. The safety analysis guidelines in BSAF provide an accepted method for hazard analysis; analysis of normal, abnormal, and accident conditions; human factors analysis; and derivation of TSRS. The BSAF safety bases and guidelines are graded for environmental restoration activities

A program optimization system for the cleanup of DOE hazardous waste sites an application to FY 1990 funding decisions

International Nuclear Information System (INIS)

Merkhofer, M.W.; Jenni, K.E.; Cotton, T.A.; Lehr, J.C.; Longo, T.P.

1989-01-01

This paper describes a formal system used by the Department of Energy (DOE) as an aid for allocating funds for cleaning up hazardous waste sites. The system, called the Program Optimization System (POS), is based on multiattribute utility analysis and was developed for DOE's Hazardous Waste and Remedial Actions Division (HWRAD). HWRAD has responsibility for recommending environmental restoration (ER) activities to the Assistant Secretary of Energy. Recently, the POS was used to analyze and recommend funding levels for FY 1990 cleanup activities at DOE defense program facilities

The use of institutional controls at Department of Energy Oak Ridge Field Office environmental restoration sites

International Nuclear Information System (INIS)

White, R.K.; Swindle, D.W.; Redfearn, A.; King, A.D.

1992-01-01

This report summarizes some of the major issues related to the use of institutional controls at hazardous waste sites under the auspices of the Department of Energy Field Office, Oak Ridge/Environmental Restoration (DOE-OR/ER) Division. In particular, the report addresses the impacts that assumptions regarding institutional controls have on the results and interpretation of the risk assessment, both in the Remedial Investigation (RI) and the Feasibility Study (FS). Environmental restoration activities at DOE-OR/ER sites are primarily driven by CERCLA. Therefore, the report focuses on the approaches and assumptions relating to institutional controls under CERCLA. Also the report briefly outlines approaches adopted under other authorities such as RCRA and radiation regulatory authorities (such as NRC regulations/guidance, DOE orders, and EPA standards) in order to contrast these approaches to those adopted under CERCLA. In order to demonstrate the implications of the use of institutional controls at DOE facilities, this report summarizes the approaches and results of the recent baseline risk assessment for Solid Waste Storage Area 6 at Oak Ridge National Laboratory. The report concludes with possible options on the use of institutional controls at DOE-OR/ER sites

US Department of Energy Oak Ridge Field Office Environmental Restoration Program review

International Nuclear Information System (INIS)

1992-05-01

This document summarizes the baselined FY 1993 Department of Energy Oak Ridge Field Office (DOE-OR) Environmental Restoration Program task priorities, budgets, and associated abbreviated task descriptions. Also included is a description of the approach utilized to establish priorities for the FY 1993 and FY 1994 budget process. Abbreviated task descriptions for FY 1994 are also included in priority listing. These FY 1994 tasks form the basis for the Activity Data Sheets prepared for DOE-OR that were submitted in May 1992

1998 Annual Report - Environmental Restoration Division

International Nuclear Information System (INIS)

Davis, L.B.

1998-01-01

This is a 1998 annual report for Environmental Restoration. Environmental Restoration's accomplishments were significant in 1998. The division, including its support organizations, completed one year without a lost time accident. It also met 111 enforceable agreement milestones on time, with more than 80% ahead of schedule. Funds used to meet these milestones were effectively utilized and $9.63 million in regulatory scope was added. Twelve new, innovative technologies were deployed, enabling ER to achieve significant progress on major field remediation projects, including: Remediation of 25 acres of radioactive burial ground; Removal of 1,300 batteries for recycling; Removal and safe storage of a radioactive underground tank; Extraction of 115,000 pounds of solvent; and Installation of 9 new recirculation wells and a second GeoSiphon Cell for additional removal of solvent Final Records of Decision were made for 9 base unit sites. No Further Action decisions were made for 61 additional sites

Checklist of flora along tourist trails to Mt. Lamongan, East Java (Indonesia: misconception of restoration and ecotourism programs in mountain region?

Directory of Open Access Journals (Sweden)

Luchman Hakim

2018-04-01

Full Text Available The aim of this research was to evaluate the diversity of plant species along the tourist trails to Mt. Lamongan and combat any misconceptions about ecosystem restoration and the ecotourism development program in Mt. Lamongan. A floristic survey was done through flora identification along the hiking trail from the gate of Mt. Lamongan nature recreation area in Papringan Village to the slopes of Mt. Lamongan. The identified species were listed and their taxonomic status analyzed using information from the GRIN website. This study found that exotic plant species are abundant along the tourist tract. Human activities were identified as contributing to the introduction and establishment of exotic plant species. Result of the research indicate that restoration knowledge and techniques do not exist in the Mt. Lamongan region. A comprehensive evaluation of flora should be implemented to enhance the restoration program and protect forest area, especially the tourist corridor to the peak of Mt. Lamongan. Integrated actions to enhance restoration and promote tourism are needed. It encompasses strengthening the restoration concept and technology, eradication of exotic plant species, and establishing a proper tourism interpretive tract.

Columbia Estuary Ecosystem Restoration Program. 2012 Synthesis Memorandum

Science.gov (United States)

2013-01-01

LCFRB Lower Columbia Fish Recovery Board LCRE lower Columbia River and estuary LCREP Lower Columbia River Estuary Partnership LWD large woody debris...hydraulic reconnections, channel creation, large woody debris [ LWD ] placement) have restored a total of 3152 acres since 2001. If land acquisition...fencing, invasive plant removal, native replanting. Mirror Lake 208 Culvert replaced with a bridge, riparian restoration, LWD enhancement, culvert

Application of safeguards technology in DOE's environmental restoration program

International Nuclear Information System (INIS)

Eccleston, G.W.; Baker, M.P.; Hansen, W.R.; Lucas, M.C.; Markin, J.T.; Phillips, J.R.

1990-01-01

During the last two decades, the Department of Energy's Office of Safeguards and Security (DOE/OSS) has supported the research and development of safeguards systems analysis methodologies and nondestructive assay (NDS) technology for characterizing, monitoring, and accounting nuclear materials. This paper discusses methodologies and NDA instrumentation developed by the DOE/OSS program that could be applied in the Environmental Restoration Program. NDA instrumentation could be used for field measurements during site characterization and to monitor nuclear materials, heavy metals, and other hazardous materials during site remediation. Systems methodologies can minimize the expenditure of resources and help specify appropriate combinations of NDA instrumentation and chemical analyses to characterize a variety of materials quickly and reduce personnel exposure in hazardous environments. A training program is available to teach fundamental and advanced principles and approaches to characterize and quantify nuclear materials properly and to organize and analyze measurement information for decision making. The ability to characterize the overall volume and distribution of materials at a waste site is difficult because of the inhomogeneous distribution of materials, the requirement for extreme sensitivity, and the lack of resources to collect and chemically analyze a sufficient number of samples. Using a systems study approach based on statistical sampling, the resources necessary to characterize a site can be enhanced by appropriately combining in situ and field NDA measurements with laboratory analyses. 35 refs., 1 figs., 2 tabs

Environmental Restoration Remedial Action quality assurance requirements document

International Nuclear Information System (INIS)

1991-01-01

This document defines the quality assurance requirements for the US Department of Energy-Richland Operations Office Environmental Restoration Remedial Action program at the Hanford Site. The Environmental Restoration Remedial Action program implements significant commitments made by the US Department of Energy in the Hanford Federal Facility Agreement and Consent Order entered into with the Washington State Department of Ecology and the US Environmental Protection Agency. This document combines quality assurance requirements from various source documents into one set of requirements for use by the US Department of Energy-Richland Operations Office and other Environmental Restoration Remedial Action program participants. This document will serve as the basis for developing Quality Assurance Program Plans and implementing procedures by the participants. The requirements of this document will be applied to activities affecting quality, using a graded approach based on the importance of the item, service, or activity to the program objectives. The Quality Assurance Program that will be established using this document as the basis, together with other program and technical documents, form an integrated management control system for conducting the Environmental Restoration Remedial Action program activities in a manner that provides safety and protects the environment and public health

How economics can further the success of ecological restoration.

Science.gov (United States)

Iftekhar, Md Sayed; Polyakov, Maksym; Ansell, Dean; Gibson, Fiona; Kay, Geoffrey M

2017-04-01

Restoration scientists and practitioners have recently begun to include economic and social aspects in the design and investment decisions for restoration projects. With few exceptions, ecological restoration studies that include economics focus solely on evaluating costs of restoration projects. However, economic principles, tools, and instruments can be applied to a range of other factors that affect project success. We considered the relevance of applying economics to address 4 key challenges of ecological restoration: assessing social and economic benefits, estimating overall costs, project prioritization and selection, and long-term financing of restoration programs. We found it is uncommon to consider all types of benefits (such as nonmarket values) and costs (such as transaction costs) in restoration programs. Total benefit of a restoration project can be estimated using market prices and various nonmarket valuation techniques. Total cost of a project can be estimated using methods based on property or land-sale prices, such as hedonic pricing method and organizational surveys. Securing continuous (or long-term) funding is also vital to accomplishing restoration goals and can be achieved by establishing synergy with existing programs, public-private partnerships, and financing through taxation. © 2016 Society for Conservation Biology.

Environmental restoration remedial action quality assurance requirements document

International Nuclear Information System (INIS)

Cote, R.F.

1991-01-01

The environmental Restoration Remedial Action Quality Assurance Requirements Document (DOE/RL 90-28) defines the quality assurance program requirements for the US Department of Energy-Richland Field Office Environmental Restoration Remedial Action Program at the Hanford Site, Richland, Washington. This paper describes the objectives outlined in DOE/RL 90-28. The Environmental Restoration Remedial Action Program implements significant commitments made by the US Department of Energy in the Hanford Federal Facility Agreement and Consent Order entered into with the Washington State Department of Ecology and the US Environmental Protection Agency

SEM evaluation of the morphological changes in hard dental tissues prepared by Er: YAG laser and rotary instruments

Directory of Open Access Journals (Sweden)

Tomov Georgi

2010-09-01

Full Text Available Effective ablation of dental hard tissues by means of the erbium:yttrium-aluminum garnet (Er: YAG laser has been reported recently, and its application to caries removal and cavity preparation has been expected. However, few studies have investigated the morphological changes in hard dental tissues after Er: YAG laser caries treatment. In the present study the morphological changes in hard dental tissues after Er: YAG laser caries ablation in vitro was compared with that of conventional mechanical treatment. Thirty extracted human teeth with caries were used. Ten tooth was treated with the Er: YAG laser, and the other was treated with a conventional steel and diamond burs. Laser treatment was performed by means of a non-contact irradiation modes with cooling water spray, with a new Er: YAG laser (LiteTouch. Conventional bur treatment was conducted by means of a low-speed micromotor and air turbine with water cooling. Scanning electron microscope (SEM observations were performed for each treatment. The Er: YAG laser ablated carious dentin effectively with minimal thermal damage to the surrounding intact dentin, and removed infected and softened carious dentin to the same degree as the burtreatment. In addition, a lower degree of vibration was noted with the Er: YAG laser treatment. The SEM examination revealed characteristic micro-irregularities of the lased dentin and enamel surfaces with potential benefits for adhesive restorations. Our results show that the Er: YAG laser is promising as a new technical modality for caries treatment

Prioritization of forest restoration projects: Tradeoffs between wildfire protection, ecological restoration and economic objectives

Science.gov (United States)

Kevin C. Vogler; Alan A. Ager; Michelle A. Day; Michael Jennings; John D. Bailey

2015-01-01

The implementation of US federal forest restoration programs on national forests is a complex process that requires balancing diverse socioecological goals with project economics. Despite both the large geographic scope and substantial investments in restoration projects, a quantitative decision support framework to locate optimal project areas and examine...

Quality assurance programs developed and implemented by the US Department of Energy's Analytical Services Program for environmental restoration and waste management activities

International Nuclear Information System (INIS)

Lillian, D.; Bottrell, D.

1993-01-01

The U.S. Department of Energy's (DOE's) Office of Environmental Restoration and Waste Management (EM) has been tasked with addressing environmental contamination and waste problems facing the Department. A key element of any environmental restoration or waste management program is environmental data. An effective and efficient sampling and analysis program is required to generate credible environmental data. The bases for DOE's EM Analytical Services Program (ASP) are contained in the charter and commitments in Secretary of Energy Notice SEN-13-89, EM program policies and requirements, and commitments to Congress and the Office of Inspector General (IG). The Congressional commitment by DOE to develop and implement an ASP was in response to concerns raised by the Chairman of the Congressional Environment, Energy, and Natural Resources Subcommittee, and the Chairman of the Congressional Oversight and Investigations Subcommittee of the Committee on Energy and Commerce, regarding the production of analytical data. The development and implementation of an ASP also satisfies the IG's audit report recommendations on environmental analytical support, including development and implementation of a national strategy for acquisition of quality sampling and analytical services. These recommendations were endorsed in Departmental positions, which further emphasize the importance of the ASP to EM's programs. In September 1990, EM formed the Laboratory Management Division (LMD) in the Office of Technology Development to provide the programmatic direction needed to establish and operate an EM-wide ASP program. In January 1992, LMD issued the open-quotes Analytical Services Program Five-Year Plan.close quotes This document described LMD's strategy to ensure the production of timely, cost-effective, and credible environmental data. This presentation describes the overall LMD Analytical Services Program and, specifically, the various QA programs

Electronic document management meets environmental restoration recordkeeping requirements: A case study

International Nuclear Information System (INIS)

Burnham, S.L.

1995-01-01

Efforts at migrating records management at five Department of Energy sites operated under management by Lockheed Martin Energy Systems, Inc. for Environmental Restoration (ER) business activities are described. The corporate environment, project definition, records keeping requirements are described first. Then an evaluation of electronic document management technologies and of internal and commercially available systems are provided. Finally adopted incremental implementation strategy and lessons learned are discussed

Characterization of the ER-Targeted Low Affinity Ca2+ Probe D4ER

Directory of Open Access Journals (Sweden)

Elisa Greotti

2016-09-01

Full Text Available Calcium ion (Ca2+ is a ubiquitous intracellular messenger and changes in its concentration impact on nearly every aspect of cell life. Endoplasmic reticulum (ER represents the major intracellular Ca2+ store and the free Ca2+ concentration ([Ca2+] within its lumen ([Ca2+]ER can reach levels higher than 1 mM. Several genetically-encoded ER-targeted Ca2+ sensors have been developed over the last years. However, most of them are non-ratiometric and, thus, their signal is difficult to calibrate in live cells and is affected by shifts in the focal plane and artifactual movements of the sample. On the other hand, existing ratiometric Ca2+ probes are plagued by different drawbacks, such as a double dissociation constant (Kd for Ca2+, low dynamic range, and an affinity for the cation that is too high for the levels of [Ca2+] in the ER lumen. Here, we report the characterization of a recently generated ER-targeted, Förster resonance energy transfer (FRET-based, Cameleon probe, named D4ER, characterized by suitable Ca2+ affinity and dynamic range for monitoring [Ca2+] variations within the ER. As an example, resting [Ca2+]ER have been evaluated in a known paradigm of altered ER Ca2+ homeostasis, i.e., in cells expressing a mutated form of the familial Alzheimer’s Disease-linked protein Presenilin 2 (PS2. The lower Ca2+ affinity of the D4ER probe, compared to that of the previously generated D1ER, allowed the detection of a conspicuous, more clear-cut, reduction in ER Ca2+ content in cells expressing mutated PS2, compared to controls.

Effectiveness of a lifestyle exercise program for older people receiving a restorative home care service: study protocol for a pragmatic randomised controlled trial.

Science.gov (United States)

Burton, Elissa; Lewin, Gill; Clemson, Lindy; Boldy, Duncan

2013-10-18

Restorative home care services help older people maximise their independence using a multi-dimensional approach. They usually include an exercise program designed to improve the older person's strength, balance and function. The types of programs currently offered require allocation of time during the day to complete specific exercises. This is not how the majority of home care clients prefer to be active and may be one of the reasons that few older people do the exercises regularly and continue the exercises post discharge.This paper describes the study protocol to test whether a Lifestyle Functional Exercise (LiFE) program: 1) is undertaken more often; 2) is more likely to be continued over the longer term; and, 3) will result in greater functional gains compared to a standard exercise program for older people receiving a restorative home care service. A pragmatic randomised controlled trial (RCT) design was employed with two study arms: LiFE program (intervention) and the current exercise program (control). Silver Chain, a health and community care organisation in Perth, Western Australia. One hundred and fifty restorative home care clients, aged 65 years and older. The primary outcome is a composite measure incorporating balance, strength and mobility. Other outcome measures include: physical functioning, falls efficacy, and levels of disability and functioning. If LiFE is more effective than the current exercise program, the evidence will be presented to the service management accompanied by the recommendation that it be adopted as the generic exercise program to be used within the restorative home care service. Australian and New Zealand Clinical Trials Registry ACTRN12611000788976.

Preliminary standard review guide for Environmental Restoration/Decontamination and Decommissioning safety analyses

International Nuclear Information System (INIS)

Ellingson, D.R.

1993-06-01

The review guide is based on the shared experiences, approaches, and philosophies of the Environmental Restoration/Decontamination and Decommissioning (ER/D ampersand D) subgroup members. It is presented in the form of a review guide to maximize the benefit to both the safety analyses practitioner and reviewer. The guide focuses on those challenges that tend to be unique to ER/D ampersand D cleanup activities. Some of these experiences, approaches, and philosophies may find application or be beneficial to a broader spectrum of activities such as terminal cleanout or even new operations. Challenges unique to ER/D ampersand D activities include (1) consent agreements requiring activity startup on designated dates; (2) the increased uncertainty of specific hazards; and (3) the highly variable activities covered under the broad category of ER/D ampersand D. These unique challenges are in addition to the challenges encountered in all activities; e.g., new and changing requirements and multiple interpretations. The experiences in approaches, methods, and solutions to the challenges are documented from the practitioner and reviewer's perspective, thereby providing the viewpoints on why a direction was taken and the concerns expressed. Site cleanup consent agreements with predetermined dates for restoration activity startup add the dimension of imposed punitive actions for failure to meet the date. Approval of the safety analysis is a prerequisite to startup. Actions that increase expediency are (1) assuring activity safety; (2) documenting that assurance; and (3) acquiring the necessary approvals. These actions increase the timeliness of startup and decrease the potential for punitive action. Improvement in expediency has been achieved by using safety analysis techniques to provide input to the line management decision process rather than as a review of line management decisions. Expediency is also improved by sharing the safety input and resultant decisions with

How Does It Work? Mechanisms of Action in an In-Prison Restorative Justice Program.

Science.gov (United States)

Armour, Marilyn; Sliva, Shannon

2018-02-01

Research is limited on mechanisms of action in restorative justice interventions. This multimethods study delineates the change processes underlying a successful in-prison group treatment program by (a) examining shifts in offenders' self-schemas and (b) identifying key program components that influence this movement. Researchers assigned to small groups as "co-facilitators" gathered data using participant observation, semi-structured interviews, and psychological assessments at three time points. Mechanisms of action include group norms and behaviors that contrast with prior experiences and uncover offenders' self-schemas through intrapsychic processes, which prompt them to test and act upon new possible selves through the group process.

Estuary ecosystem restoration: implementing and institutionalizing adaptive management: Institutionalizing adaptive management

Energy Technology Data Exchange (ETDEWEB)

Ebberts, Blaine D. [Portland District, U.S. Army Corps of Engineers, 333 SW 1st Avenue, Portland OR 97204 U.S.A.; Zelinsky, Ben D. [Fish and Wildlife Division, Bonneville Power Administration, 905 NE 11th Avenue, Portland OR 97208 U.S.A.; Karnezis, Jason P. [Fish and Wildlife Division, Bonneville Power Administration, 905 NE 11th Avenue, Portland OR 97208 U.S.A.; Studebaker, Cynthia A. [Portland District, U.S. Army Corps of Engineers, 333 SW 1st Avenue, Portland OR 97204 U.S.A.; Lopez-Johnston, Siena [Fish and Wildlife Division, Bonneville Power Administration, 905 NE 11th Avenue, Portland OR 97208 U.S.A.; Creason, Anne M. [Fish and Wildlife Division, Bonneville Power Administration, 905 NE 11th Avenue, Portland OR 97208 U.S.A.; Krasnow, Lynne [Columbia Hydropower Branch, National Marine Fisheries Service, 1201 NE Lloyd Boulevard Suite 1100, Portland OR 97232 U.S.A.; Johnson, Gary E. [Pacific Northwest National Laboratory, 620 SW 5th Avenue, Suite 810, Portland OR 97204 U.S.A.; Thom, Ronald M. [Pacific Northwest National Laboratory, Marine Science Laboratory, 1286 Washington Harbor Road, Sequim WA 98382 U.S.A.

2017-08-25

We successfully implemented and institutionalized an adaptive management (AM) process for the Columbia Estuary Ecosystem Restoration Program, which is a large-scale restoration program focused on improving ecosystem conditions in the 234-km lower Columbia River and estuary. For our purpose, “institutionalized” means the AM process and restoration program are embedded in the work flow of the implementing agencies and affected parties. While plans outlining frameworks, processes, or approaches to AM of ecosystem restoration programs are commonplace, establishment for the long term is not. This paper presents the basic AM framework and explains how AM was implemented and institutionalized. Starting with a common goal, we pursued included a well-understood governance and decision-making structure, routine coordination and communication activities, data and information sharing, commitment from partners and upper agency management to the AM process, and meaningful cooperation among program managers and partners. The overall approach and steps to implement and institutionalize AM for ecosystem restoration explained here are applicable to situations where it has been less than successful or, as in our case, the restoration program is just getting started.

Marginal microleakage in vitro study of occlusal fissures sealing prepared and etched or not with Er: YAG laser; Avaliacao in vitro da microinfiltracao marginal em selamentos oclusais preparados e condicionados ou nao pelo laser de Er:YAG

Energy Technology Data Exchange (ETDEWEB)

Youssef, Fernanda de Almeida

2004-07-01

The aim of this in vitro study was to evaluate the degree of marginal microleakage in occlusal sealing by invasive techniques, after preparation with Er:YAG laser followed or not by Er:YAG laser etching and compared to the conventional technique. Thirty human premolars were divided into three groups: A (control group) - cavities were prepared with high speed and etched with 37% orthophosphoric acid; group B - cavities were prepared with Er:YAG (350 mJ, 4 Hz and 112 J /cm{sup 2}) and etched with 37% orthophosphoric acid; group C - cavities were prepared with Er:YAG laser (350 mJ, 4 Hz and 112 J/cm{sup 2}), and etched with Er:YAG laser (80 mJ, 4 Hz and 25 m/cm{sup 2}). All cavities were treated with the same adhesive system and restored with flow composite according to manufacturer instructions. Teeth were submitted to thermal cycling procedures and immersed in 50% Silver Nitrate Solutions for 8 hours in total darkness. Teeth were sectioned longitudinally in the bucco-lingual direction, in slices of 1 mm thick. Each slice was immersed into photo developing solution under 16 hours of fluorescent light. Slices were photographed and microleakage was scored from 0 to 7 J by three standard examiners. Results showed statistically significant differences for group C (Er:YAG laser preparation and etching). We concluded that Er:YAG laser can be used for cavity preparation of occlusal sealing, like the conventional high speed method. However, this laser, used as enamel etching agent, could not promote an adequate surface for adhesive procedures. (author)

Pollution prevention and waste minimization opportunity assessment in environmental restoration

International Nuclear Information System (INIS)

Roybal, J.A.; Willison, C.P.

1997-01-01

The Environmental Restoration (ER) Project at Sandia National Laboratories implicitly subscribed to the philosophy of pollution prevention and waste minimization. As a result of a Department of Energy (DOE) offer, Pollution Prevention Opportunity Assessments (PPOA) were conducted at two ER sites and a decontamination and Demolition (D and D) site. The purpose of one of the PPOAs was to identify pollution prevention (P2) opportunities during environmental remediation at the Classified Waste Landfill located at Sandia National Laboratories, New Mexico (SNL/NM). The remediation activities at this site are scheduled to begin in the fall of 1997. The PPOA included presentations by the team members, a tour of the site, and a brainstorming session to list the waste streams, identify P2 opportunities and rank them in order of priority. Twenty-five P2 opportunities were identified during the brainstorming session of which twenty-two opportunities were selected for further investigation. Those twenty-two opportunities are discussed in this paper. A cost benefit analysis was performed for each P2 opportunity based on the estimated waste volume, feasibility, and cost. Pollution Prevention by Design (P2D) was incorporated into the PPOA to introduce waste minimization techniques that can be used during the planning phase of restoration projects

Examining the effectiveness of a restorative justice program for various types of juvenile offenders.

Science.gov (United States)

Bergseth, Kathleen J; Bouffard, Jeffrey A

2013-09-01

Restorative justice (RJ) programs have become widespread in the United States and in other countries. These programs are often seen as a viable alternative to traditional retributive processing, especially for minor, and sometimes more serious, forms of delinquency and adult criminality. The programs hold promise for achieving several goals, including increased community and victim involvement, greater satisfaction with the case outcomes, improved offender compliance, increased perceptions of fairness, and even recidivism reduction. Meta-analyses have demonstrated varying degrees of program success in recidivism reduction, which may in part reflect differential effectiveness of the RJ approach for various kinds of offenders. This study examined whether an RJ program for juvenile offenders had differential impacts on recidivism across various offender characteristics (including age, gender, racial group, offending history, and current offense). Results generally support the effectiveness of the program for many types of offenders. Implications for future research and potential improvements to the RJ model are discussed.

The Oncor Geodatabase for the Columbia Estuary Ecosystem Restoration Program: Handbook of Data Reduction Procedures, Workbooks, and Exchange Templates

Energy Technology Data Exchange (ETDEWEB)

Sather, Nichole K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Borde, Amy B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Diefenderfer, Heida L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Serkowski, John A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Coleman, Andre M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Johnson, Gary E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2013-12-01

This Handbook of Data Reduction Procedures, Workbooks, and Exchange Templates is designed to support the Oncor geodatabase for the Columbia Estuary Ecosystem Restoration Program (CEERP). The following data categories are covered: water-surface elevation and temperature, sediment accretion rate, photo points, herbaceous wetland vegetation cover, tree plots and site summaries, fish catch and density, fish size, fish diet, fish prey, and Chinook salmon genetic stock identification. The handbook is intended for use by scientists collecting monitoring and research data for the CEERP. The ultimate goal of Oncor is to provide quality, easily accessible, geospatial data for synthesis and evaluation of the collective performance of CEERP ecosystem restoration actions at a program scale.

Politik er ikke lykken

DEFF Research Database (Denmark)

Steenbuch, Johannes Aakjær

2011-01-01

Der er ikke længere nogen højere sandhed i livet end den, flertallet bestemmer sig for – og dermed ingen del af livet, der ikke er politisk. Højre- og venstrefløjen er i bund og grund enige - enige om, at det er politikernes opgave at forære os det gode liv. Dermed bliver demokratiet totalitært. ...

Technical approach to groundwater restoration

International Nuclear Information System (INIS)

1993-01-01

The Technical Approach to Groundwater Restoration (TAGR) provides general technical guidance to implement the groundwater restoration phase of the Uranium Mill Tailings Remedial Action (UMTRA) Project. The TAGR includes a brief overview of the surface remediation and groundwater restoration phases of the UMTRA Project and describes the regulatory requirements, the National Environmental Policy Act (NEPA) process, and regulatory compliance. A section on program strategy discusses program optimization, the role of risk assessment, the observational approach, strategies for meeting groundwater cleanup standards, and remedial action decision-making. A section on data requirements for groundwater restoration evaluates the data quality objectives (DQO) and minimum data required to implement the options and comply with the standards. A section on sits implementation explores the development of a conceptual site model, approaches to site characterization, development of remedial action alternatives, selection of the groundwater restoration method, and remedial design and implementation in the context of site-specific documentation in the site observational work plan (SOWP) and the remedial action plan (RAP). Finally, the TAGR elaborates on groundwater monitoring necessary to evaluate compliance with the groundwater cleanup standards and protection of human health and the environment, and outlines licensing procedures

Department of the Army Installation Restoration Program

International Nuclear Information System (INIS)

Anderson, A.W.

1988-01-01

The Army's Installation Restoration Program (IRP) was established in 1975 in response to regulatory action at several installations where past disposal practices had caused contamination of streams and groundwater. The need to decontaminate excess Army-owned real estate also was considered in early IRP activities. A variety of site types have been discovered on Army installations. The major site types evaluated to date include: contaminated soil areas, landfills, lagoons, buildings, burning grounds, sumps, pits, storage tanks, sewage treatment plants, storage pads, industrial wastewater treatment plants, and salvage yards. Twenty Army installations have been proposed for or listed on the National Priorities List (NPL). The need for taking action at hazardous waste sites, however, is based on threats they pose to human health, welfare or the environment. Sites do not have to be on the SPL in order to be cleaned up through IRP activities. All of the sites that caused Army installations to be proposed for the NPL are being evaluated and cleaned up. In addition, all Army properties have been or will be assessed and where needed they will be addressed by the IRP

Quality assurance programs developed and implemented by the US Department of Energy`s Analytical Services Program for environmental restoration and waste management activities

Energy Technology Data Exchange (ETDEWEB)

Lillian, D.; Bottrell, D. [Dept. of Energy, Germntown, MD (United States)

1993-12-31

The U.S. Department of Energy`s (DOE`s) Office of Environmental Restoration and Waste Management (EM) has been tasked with addressing environmental contamination and waste problems facing the Department. A key element of any environmental restoration or waste management program is environmental data. An effective and efficient sampling and analysis program is required to generate credible environmental data. The bases for DOE`s EM Analytical Services Program (ASP) are contained in the charter and commitments in Secretary of Energy Notice SEN-13-89, EM program policies and requirements, and commitments to Congress and the Office of Inspector General (IG). The Congressional commitment by DOE to develop and implement an ASP was in response to concerns raised by the Chairman of the Congressional Environment, Energy, and Natural Resources Subcommittee, and the Chairman of the Congressional Oversight and Investigations Subcommittee of the Committee on Energy and Commerce, regarding the production of analytical data. The development and implementation of an ASP also satisfies the IG`s audit report recommendations on environmental analytical support, including development and implementation of a national strategy for acquisition of quality sampling and analytical services. These recommendations were endorsed in Departmental positions, which further emphasize the importance of the ASP to EM`s programs. In September 1990, EM formed the Laboratory Management Division (LMD) in the Office of Technology Development to provide the programmatic direction needed to establish and operate an EM-wide ASP program. In January 1992, LMD issued the {open_quotes}Analytical Services Program Five-Year Plan.{close_quotes} This document described LMD`s strategy to ensure the production of timely, cost-effective, and credible environmental data. This presentation describes the overall LMD Analytical Services Program and, specifically, the various QA programs.

ER Consolidated Qtrly Rpt_July-September 2015_January 2016

Energy Technology Data Exchange (ETDEWEB)

Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-01-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented by Sandia National Laboratories, New Mexico (SNL/NM) for the July, August, and September 2015 quarterly reporting period. The Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM are listed in Table I-1. The work completed during this quarter is reported below in Sections I.2.1 and I.2.2. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities (SWMUs 8 and 58, 68, 149, 154, and 502, and three groundwater AOCs). Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) has issued a certificate of completion and the site is in the corrective action complete (CAC) regulatory process. Currently, the Mixed Waste Landfill (MWL, SWMU 76) is the only site in the CAC regulatory process. Corrective action activities have been deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these are active mission facilities.

Waves in Seagrass Systems: Review and Technical Recommendations

Science.gov (United States)

2006-11-01

Florida, St. Petersburg, FL, 123 pp. Koch, E. W. 1994. Hydrodynamics, diffusion boundary layers and photosynthesis of the seagrasses Thalassia testudinum...ER D C TR -0 6- 15 System-Wide Water Resources Program Submerged Aquatic Vegetation Restoration Research Program Waves in Seagrass ...Water Resources Research Program and Submerged Aquatic Vegetation Restoration Research Program ERDC TR-06-15 November 2006 Waves in Seagrass Systems

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Science.gov (United States)

Plate, Lars; Cooley, Christina B; Chen, John J; Paxman, Ryan J; Gallagher, Ciara M; Madoux, Franck; Genereux, Joseph C; Dobbs, Wesley; Garza, Dan; Spicer, Timothy P; Scampavia, Louis; Brown, Steven J; Rosen, Hugh; Powers, Evan T; Walter, Peter; Hodder, Peter; Wiseman, R Luke; Kelly, Jeffery W

2016-01-01

Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UPR)-associated transcription factor ATF6 attenuates secretion and extracellular aggregation of amyloidogenic proteins. Here, we employed a screening approach that included complementary arm-specific UPR reporters and medium-throughput transcriptional profiling to identify non-toxic small molecules that phenocopy the ATF6-mediated reprogramming of the ER proteostasis environment. The ER reprogramming afforded by our molecules requires activation of endogenous ATF6 and occurs independent of global ER stress. Furthermore, our molecules phenocopy the ability of genetic ATF6 activation to selectively reduce secretion and extracellular aggregation of amyloidogenic proteins. These results show that small molecule-dependent ER reprogramming, achieved through preferential activation of the ATF6 transcriptional program, is a promising strategy to ameliorate imbalances in ER function associated with degenerative protein aggregation diseases. DOI: http://dx.doi.org/10.7554/eLife.15550.001 PMID:27435961

ANL Technical Support Program for DOE Environmental Restoration and Waste Management

International Nuclear Information System (INIS)

Bates, J.K.; Bradley, C.R.; Buck, E.C.; Cunnane, J.C.; Dietz, N.L.; Ebert, W.L.; Emery, J.W.; Feng, X.; Gerding, T.J.; Gong, M.; Hoh, J.C.; Mazer, J.J.; Wronkiewicz, D.J.; Bourcier, W.L.; Morgan, L.E.; Nielsen, J.K.; Steward, S.A.; Ewing, R.C.; Wang, L.M.; Han, W.T.; Tomozawa, M.

1992-03-01

This report provides an overview of progress during FY 1991 for the Technical Support Program that is part of the ANL Technology Support Activity for DOE, Environmental Restoration and Waste Management (EM). The purpose is to evaluate, before hot start-up of the Defenses Waste Processing Facility (DWPF) and the West Valley Demonstration Project (WVDP), factors that are likely to affect glass reaction in an unsaturated environment typical of what may be expected for the candidate Yucca Mountain repository site. Specific goals for the testing program include the following: (1) to review and evaluate available information on parameters that will be important in establishing the long-term performance of glass in a repository environment; (2) to perform testing to further quantify the effects of important variables where there are deficiencies in the available data; and (3) to initiate long-term testing that will bound glass performance under a range of conditions applicable to repository disposal

Vreden er over os

DEFF Research Database (Denmark)

Mehlsen, Camilla

2006-01-01

Urolige elever, cyklister - der giver fuck-finger, aggressive demonstranter. Samtiden er på vej ind i en æra domineret af vrede, siger rektor Lars-Henrik Schmidt, der er aktuel med bogen 'Om vreden'. Udgivelsesdato: Juni......Urolige elever, cyklister - der giver fuck-finger, aggressive demonstranter. Samtiden er på vej ind i en æra domineret af vrede, siger rektor Lars-Henrik Schmidt, der er aktuel med bogen 'Om vreden'. Udgivelsesdato: Juni...

The land value impacts of wetland restoration.

Science.gov (United States)

Kaza, Nikhil; BenDor, Todd K

2013-09-30

U.S. regulations require offsets for aquatic ecosystems damaged during land development, often through restoration of alternative resources. What effect does large-scale wetland and stream restoration have on surrounding land values? Restoration effects on real estate values have substantial implications for protecting resources, increasing tax base, and improving environmental policies. Our analysis focuses on the three-county Raleigh-Durham-Chapel Hill, North Carolina region, which has experienced rapid development and extensive aquatic ecological restoration (through the state's Ecosystem Enhancement Program [EEP]). Since restoration sites are not randomly distributed across space, we used a genetic algorithm to match parcels near restoration sites with comparable control parcels. Similar to propensity score analysis, this technique facilitates statistical comparison and isolates the effects of restoration sites on surrounding real estate values. Compared to parcels not proximate to any aquatic resources, we find that, 1) natural aquatic systems steadily and significantly increase parcel values up to 0.75 mi away, and 2) parcels 0.5 mi from EEP sites gain substantial amenity value. When we control for intervening water bodies (e.g. un-restored streams and wetlands), we find a similar inflection point whereby parcels points to the need for higher public visibility of aquatic ecosystem restoration programs and increased public information about their value. Copyright © 2013 Elsevier Ltd. All rights reserved.

Fisheries Restoration Grant Program Projects [ds168

Data.gov (United States)

California Natural Resource Agency — This shapefile (FRGP_All_020209.shp) represents the locations of all ongoing and completed salmonid restoration projects in California with existing records in the...

Supplement Analysis for the Watershed Management Program EIS--Tapteal Bend Riparian Corridor Restoration Project

Energy Technology Data Exchange (ETDEWEB)

N/A

2004-08-11

The Bonneville Power Administration is proposing to fund the restoration of approximately 500 feet of streambank along the Yakima River at river mile 8, upstream of the Van Giesen Bridge on SR 224, in and between Richland and West Richland, Washington. This project will also result in the acquisition of Fox Island, a 12-acre island directly across the river from the restoration area. There is no development planned for the island. The proposed project includes: The installation of a bio-engineered streambank that incorporates barbs to capture silt and deflect flow, roughened rock or log toes, a riparian buffer, soil reinforcement, and bank grading. Long-term photo-point and plot sampling will also be implemented to evaluate the effectiveness and success of the restoration project. The NEPA compliance checklist for this project was completed by Darrel Sunday, a contractor with Sunday and Associates, Inc. (April 4, 2004), and meets the standards and guidelines for the Watershed Management Program Environmental Impact Statement (EIS) and Record of Decision (ROD). The Endangered Species Act (ESA) listed species that may occur in the general vicinity of the project area are the pygmy rabbit, bald eagle, bull trout, Ute ladies'-tresses, and mid-Columbia Steelhead. The pygmy rabbit, bald eagle, and Ute ladies'Tresses are not known to occur in the immediate project vicinity, and it was determined that the proposed restoration project would have no effect on these species. It is difficult to determine if bull trout occur within the Tapteal project area and Dave Carl of the Washington Department of Fish & Wildlife was contacted and concurred with this assumption. It was determined that the project may affect, but is not likely to adversely affect bull trout, and the U.S. Fish & Wildlife Service has concurred with that determination (July 28, 2004). For the mid-Columbia Steelhead, an anadromous fish species, BPA has determined that if conducted in accordance with

ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis

Directory of Open Access Journals (Sweden)

Diane DeZwaan-McCabe

2017-05-01

Full Text Available The unfolded protein response (UPR, induced by endoplasmic reticulum (ER stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppression of metabolic genes. The mechanisms of this accumulation, including which pathways contribute to the phenotype in each organ, are unclear. We combined gene expression profiling, biochemical assays, and untargeted lipidomics to understand the basis of stress-dependent lipid accumulation, taking advantage of enhanced hepatic and renal steatosis in mice lacking the ER stress sensor ATF6α. We found that impaired fatty acid oxidation contributed to the early development of steatosis in the liver but not the kidney, while anorexia-induced lipolysis promoted late triglyceride and free fatty acid accumulation in both organs. These findings provide evidence for both direct and indirect regulation of peripheral metabolism by ER stress.

ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis.

Science.gov (United States)

DeZwaan-McCabe, Diane; Sheldon, Ryan D; Gorecki, Michelle C; Guo, Deng-Fu; Gansemer, Erica R; Kaufman, Randal J; Rahmouni, Kamal; Gillum, Matthew P; Taylor, Eric B; Teesch, Lynn M; Rutkowski, D Thomas

2017-05-30

The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppression of metabolic genes. The mechanisms of this accumulation, including which pathways contribute to the phenotype in each organ, are unclear. We combined gene expression profiling, biochemical assays, and untargeted lipidomics to understand the basis of stress-dependent lipid accumulation, taking advantage of enhanced hepatic and renal steatosis in mice lacking the ER stress sensor ATF6α. We found that impaired fatty acid oxidation contributed to the early development of steatosis in the liver but not the kidney, while anorexia-induced lipolysis promoted late triglyceride and free fatty acid accumulation in both organs. These findings provide evidence for both direct and indirect regulation of peripheral metabolism by ER stress. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Restorative Justice at Work: Examining the Impact of Restorative Justice Resolutions on Juvenile Recidivism

Science.gov (United States)

Rodriguez, Nancy

2007-01-01

Programs with restorative justice ideals attempt to incorporate victims and community members into the administration of justice. Although these programs have become increasingly popular, only a few programs in the United States have been the focus of prior studies. Using official juvenile court data from an urban, metropolitan area, this study…

Final report on the Background Soil Characterization Project at the Oak Ridge Reservation, Oak Ridge, Tennessee. Volume 1: Results of Field Sampling Program

Energy Technology Data Exchange (ETDEWEB)

Watkins, D.R.; Ammons, J.T.; Branson, J.L. [and others

1993-10-01

This report presents, evaluates, and documents data and results obtained in the Background Soil Characterization Project (BSCP). It is intended to be a stand-alone document for application and use in structuring and conducting remedial investigation and remedial action projects in the Environmental Restoration (ER) Program. The objectives of the BSCP consist of the following: determine background concentrations of organics, metals, and radionuclides in natural soils that are key to environmental restoration projects; provide remediation projects with 100% validated data on background concentrations, which are technically and legally defensible; and quantify baseline risks from background constituents for comparison of risks associated with contaminated sites.

Completion Report for Well ER-EC-15 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Management

2011-05-31

Well ER-EC-15 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly known as the Nevada Test Site), Nye County, Nevada. The well was drilled in October and November 2010, as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to provide detailed hydrogeologic information in the Tertiary volcanic section in the area between Pahute Mesa and the Timber Mountain caldera complex that will help address uncertainties within the Pahute Mesa–Oasis Valley hydrostratigraphic model. In particular, the well was intended to help define the structural position and hydraulic parameters of volcanic aquifers potentially down-gradient from underground nuclear tests on Pahute Mesa. It may also be used as a long-term monitoring well.

Completion Report for Well ER-EC-12 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Management

2011-04-30

Well ER-EC-12 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly known as the Nevada Test Site), Nye County, Nevada. The well was drilled in June and July 2010 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to provide detailed hydrogeologic information in the Tertiary volcanic section in the area between Pahute Mesa and the Timber Mountain caldera complex that will help address uncertainties within the Pahute Mesa–Oasis Valley hydrostratigraphic model. In particular, the well was intended to help define the structural position and hydraulic parameters for volcanic aquifers potentially down-gradient from historic underground nuclear tests on Pahute Mesa. It may also be used as a long-term monitoring well.

COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.

Science.gov (United States)

Fang, Jingye; Liu, Ming; Zhang, Xuebao; Sakamoto, Takeshi; Taatjes, Douglas J; Jena, Bhanu P; Sun, Fei; Woods, James; Bryson, Tim; Kowluru, Anjaneyulu; Zhang, Kezhong; Chen, Xuequn

2015-08-01

Pancreatic β-cells possess a highly active protein synthetic and export machinery in the endoplasmic reticulum (ER) to accommodate the massive production of proinsulin. ER homeostasis is vital for β-cell functions and is maintained by the delicate balance between protein synthesis, folding, export, and degradation. Disruption of ER homeostasis by diabetes-causing factors leads to β-cell death. Among the 4 components to maintain ER homeostasis in β-cells, the role of ER export in insulin biogenesis is the least understood. To address this knowledge gap, the present study investigated the molecular mechanism of proinsulin ER export in MIN6 cells and primary islets. Two inhibitory mutants of the secretion-associated RAS-related protein (Sar)1 small GTPase, known to specifically block coat protein complex II (COPII)-dependent ER export, were overexpressed in β-cells using recombinant adenoviruses. Results from this approach, as well as small interfering RNA-mediated Sar1 knockdown, demonstrated that defective Sar1 function blocked proinsulin ER export and abolished its conversion to mature insulin in MIN6 cells, isolated mouse, and human islets. It is further revealed, using an in vitro vesicle formation assay, that proinsulin was packaged into COPII vesicles in a GTP- and Sar1-dependent manner. Blockage of COPII-dependent ER exit by Sar1 mutants strongly induced ER morphology change, ER stress response, and β-cell apoptosis. These responses were mediated by the PKR (double-stranded RNA-dependent kinase)-like ER kinase (PERK)/eukaryotic translation initiation factor 2α (p-eIF2α) and inositol-requiring protein 1 (IRE1)/x-box binding protein 1 (Xbp1) pathways but not via activating transcription factor 6 (ATF6). Collectively, results from the study demonstrate that COPII-dependent ER export plays a vital role in insulin biogenesis, ER homeostasis, and β-cell survival.

Drivers of Ecological Restoration: Lessons from a Century of Restoration in Iceland

Directory of Open Access Journals (Sweden)

Ása L. Aradóttir

2013-12-01

Full Text Available We analyzed the main drivers for ecological restoration in Iceland from 1907 to 2010 and assessed whether the drivers have changed over time and what factors might explain the changes, if any. Our study was based on a catalogue of 100 restoration projects, programs, and areas, representing 75% to 85% of all restoration activities in Iceland. Catastrophic erosion was an early driver for soil conservation and restoration efforts that still ranked high in the 2000s, reflecting the immense scale of soil erosion and desertification in Iceland. Socioeconomic drivers such as farming and the provision of wood products were strong motivators of ecological restoration over most of the 20th century, although their relative importance decreased with time as the number and diversity of drivers increased. In the 1960s and 1970s, the construction of hard infrastructure, and moral values such as improving the aesthetics of the countryside and "repaying the debt to the land" emerged as motivations for restoration actions. In the late 1990s, the United Nations Climate Change Convention became a driver for restoration, and the importance of nature conservation and recreation increased. Technological development and financial incentives did not show up as drivers of ecological restoration in our study, although there are some indications of their influence. Furthermore, policy was a minor driver, which might reflect weak policy instruments for ecological restoration and some counteractive policies.

Standard review plan for the review of environmental restoration remedial action quality assurance program plans

International Nuclear Information System (INIS)

1991-09-01

This plan establishes both the scope of the review and the acceptance criteria to be utilized for the review of Quality Assurance Program Plans (QAPPs) developed in accordance with the requirements of DOE/RL-90-28. DOE/RL-90-28, the Environmental Restoration Remedial Action Quality Assurance Requirements Document (QARD) defines all quality assurance (QA) requirements governing activities that affect the quality of the Environmental Restoration Remedial Action (ERRA) program at the Hanford Site. These requirements are defined in three parts, Part 1 of Quality Management and Administration tasks, Part 2 for Environmental Data Operations, and Part 3 of the Design and Construction of items, systems, and facilities. The purpose of this document is to identify the scope of the review by the DOE Field Office, Richland staff, and establish the acceptance criteria (Parts 1, 2, and 3) that the DOE Field Office, Richland staff will utilize to evaluate the participant QAPPs. Use of the standard review plan will (1) help ensure that participant QAPPs contain the information required by DOE/RL-90-28, (2) aid program participant and DOE Field Office, Richland staff is ensuring that the information describing the participant's QAPP is complete, (3) help persons regarding DOE/RL- 90-28 to locate information, and (4) contribute to decreasing the time needed for the review process. In addition, the Standard Review Plan (SRP) ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate compliance of participant quality programs against DOE/RL-90-28

Prioritization of Forest Restoration Projects: Tradeoffs between Wildfire Protection, Ecological Restoration and Economic Objectives

Directory of Open Access Journals (Sweden)

Kevin C. Vogler

2015-12-01

Full Text Available The implementation of US federal forest restoration programs on national forests is a complex process that requires balancing diverse socioecological goals with project economics. Despite both the large geographic scope and substantial investments in restoration projects, a quantitative decision support framework to locate optimal project areas and examine tradeoffs among alternative restoration strategies is lacking. We developed and demonstrated a new prioritization approach for restoration projects using optimization and the framework of production possibility frontiers. The study area was a 914,657 ha national forest in eastern Oregon, US that was identified as a national priority for restoration with the goal of increasing fire resiliency and sustaining ecosystem services. The results illustrated sharp tradeoffs among the various restoration goals due to weak spatial correlation of forest stressors and provisional ecosystem services. The sharpest tradeoffs were found in simulated projects that addressed either wildfire risk to the urban interface or wildfire hazard, highlighting the challenges associated with meeting both economic and fire protection goals. Understanding the nature of tradeoffs between restoration objectives and communicating them to forest stakeholders will allow forest managers to more effectively design and implement economically feasible restoration projects.

Summary of the landfill remediation problems and technology needs of the Oak Ridge Reservation Environmental Restoration Programs

International Nuclear Information System (INIS)

1991-01-01

This report discusses the following topics: brief description of the Oak Ridge Reservation Environmental Restoration Program; descriptions of representative waste burials at each site; ongoing, planned, or potential remediation; known or anticipated remediation problems; potential applications for robotics in the remediation of Oak Ridge Reservation landfills

Effects of material growth technique and Mg doping on Er3+ photoluminescence in Er-implanted GaN

International Nuclear Information System (INIS)

Kim, S.; Henry, R. L.; Wickenden, A. E.; Koleske, D. D.; Rhee, S. J.; White, J. O.; Myoung, J. M.; Kim, K.; Li, X.; Coleman, J. J.

2001-01-01

Photoluminescence (PL) and photoluminescence excitation (PLE) spectroscopies have been carried out at 6 K on the ∼1540 nm 4 I 13/2 - 4 I 15/2 emissions of Er 3+ in Er-implanted and annealed GaN. These studies revealed the existence of multiple Er 3+ centers and associated PL spectra in Er-implanted GaN films grown by metalorganic chemical vapor deposition, hydride vapor phase epitaxy, and molecular beam epitaxy. The results demonstrate that the multiple Er 3+ PL centers and below-gap defect-related absorption bands by which they are selectively excited are universal features of Er-implanted GaN grown by different techniques. It is suggested that implantation-induced defects common to all the GaN samples are responsible for the Er site distortions that give rise to the distinctive, selectively excited Er 3+ PL spectra. The investigations of selectively excited Er 3+ PL and PLE spectra have also been extended to Er-implanted samples of Mg-doped GaN grown by various techniques. In each of these samples, the so-called violet-pumped Er 3+ PL band and its associated broad violet PLE band are significantly enhanced relative to the PL and PLE of the other selectively excited Er 3+ PL centers. More importantly, the violet-pumped Er 3+ PL spectrum dominates the above-gap excited Er 3+ PL spectrum of Er-implanted Mg-doped GaN, whereas it was unobservable under above-gap excitation in Er-implanted undoped GaN. These results confirm the hypothesis that appropriate codopants can increase the efficiency of trap-mediated above-gap excitation of Er 3+ emission in Er-implanted GaN. [copyright] 2001 American Institute of Physics

Man er aldrig alene

DEFF Research Database (Denmark)

Hoffmeyer, Jesper

2013-01-01

Nu ved vi, at der er mange slags DNA i vores krop, og at samarbejdet mellem de organismer, som bærer alt dette DNA, er essentielt for vores overlevelse" … "Kroppen er en slags økosystem, hvor alle slags samarbejde hen ad vejen bliver afprøvet"...

Functional characterization of the ER stress induced X-box-binding protein-1 (Xbp-1 in the porcine system

Directory of Open Access Journals (Sweden)

Jin Dong-Il

2011-05-01

Full Text Available Abstract Background The unfolded protein response (UPR is an evolutionary conserved adaptive reaction for increasing cell survival under endoplasmic reticulum (ER stress conditions. X-box-binding protein-1 (Xbp1 is a key transcription factor of UPR that activates genes involved in protein folding, secretion, and degradation to restore ER function. The UPR induced by ER stress was extensively studied in diseases linked to protein misfolding and aggregations. However, in the porcine system, genes in the UPR pathway were not investigated. In this study, we isolated and characterized the porcine Xbp1 (pXbp1 gene in ER stress using porcine embryonic fibroblast (PEF cells and porcine organs. ER stress was induced by the treatment of tunicamycin and cell viability was investigated by the MTT assay. For cloning and analyzing the expression pattern of pXbp1, RT-PCR analysis and Western blot were used. Knock-down of pXbp1 was performed by the siRNA-mediated gene silencing. Results We found that the pXbp1 mRNA was the subject of the IRE1α-mediated unconventional splicing by ER stress. Knock-down of pXbp1 enhanced ER stress-mediated cell death in PEF cells. In adult organs, pXbp1 mRNA and protein were expressed and the spliced forms were detected. Conclusions It was first found that the UPR mechanisms and the function of pXbp1 in the porcine system. These results indicate that pXbp1 plays an important role during the ER stress response like other animal systems and open a new opportunity for examining the UPR pathway in the porcine model system.

Marginal microleakage in vitro study of occlusal fissures sealing prepared and etched or not with Er: YAG laser

International Nuclear Information System (INIS)

Youssef, Fernanda de Almeida

2004-01-01

The aim of this in vitro study was to evaluate the degree of marginal microleakage in occlusal sealing by invasive techniques, after preparation with Er:YAG laser followed or not by Er:YAG laser etching and compared to the conventional technique. Thirty human premolars were divided into three groups: A (control group) - cavities were prepared with high speed and etched with 37% orthophosphoric acid; group B - cavities were prepared with Er:YAG (350 mJ, 4 Hz and 112 J /cm 2 ) and etched with 37% orthophosphoric acid; group C - cavities were prepared with Er:YAG laser (350 mJ, 4 Hz and 112 J/cm 2 ), and etched with Er:YAG laser (80 mJ, 4 Hz and 25 m/cm 2 ). All cavities were treated with the same adhesive system and restored with flow composite according to manufacturer instructions. Teeth were submitted to thermal cycling procedures and immersed in 50% Silver Nitrate Solutions for 8 hours in total darkness. Teeth were sectioned longitudinally in the bucco-lingual direction, in slices of 1 mm thick. Each slice was immersed into photo developing solution under 16 hours of fluorescent light. Slices were photographed and microleakage was scored from 0 to 7 J by three standard examiners. Results showed statistically significant differences for group C (Er:YAG laser preparation and etching). We concluded that Er:YAG laser can be used for cavity preparation of occlusal sealing, like the conventional high speed method. However, this laser, used as enamel etching agent, could not promote an adequate surface for adhesive procedures. (author)

Environmental restoration plan for the transfer of surplus facilities to the Facility Transition Program at Oak Ridge National Laboratory

International Nuclear Information System (INIS)

1995-08-01

This report will provide guidance on management, coordination, and integration of plans to transition facilities to the Facility Transition Program and activities as related to the Oak Ridge National Laboratory (ORNL) Environmental Restoration Program facilities. This report gives (1) guidance on the steps necessary for identifying ORNL surplus facilities, (2) interfaces of Surveillance and Maintenance (S and M) and Isotope Facility Deactivation program managers, (3) roles and responsibilities of the facility managers, and (4) initial S and M requirements upon acceptance into the Facility Transition Program

Regional restoration benchmarks for Acropora cervicornis

Science.gov (United States)

Schopmeyer, Stephanie A.; Lirman, Diego; Bartels, Erich; Gilliam, David S.; Goergen, Elizabeth A.; Griffin, Sean P.; Johnson, Meaghan E.; Lustic, Caitlin; Maxwell, Kerry; Walter, Cory S.

2017-12-01

Coral gardening plays an important role in the recovery of depleted populations of threatened Acropora cervicornis in the Caribbean. Over the past decade, high survival coupled with fast growth of in situ nursery corals have allowed practitioners to create healthy and genotypically diverse nursery stocks. Currently, thousands of corals are propagated and outplanted onto degraded reefs on a yearly basis, representing a substantial increase in the abundance, biomass, and overall footprint of A. cervicornis. Here, we combined an extensive dataset collected by restoration practitioners to document early (1-2 yr) restoration success metrics in Florida and Puerto Rico, USA. By reporting region-specific data on the impacts of fragment collection on donor colonies, survivorship and productivity of nursery corals, and survivorship and productivity of outplanted corals during normal conditions, we provide the basis for a stop-light indicator framework for new or existing restoration programs to evaluate their performance. We show that current restoration methods are very effective, that no excess damage is caused to donor colonies, and that once outplanted, corals behave just as wild colonies. We also provide science-based benchmarks that can be used by programs to evaluate successes and challenges of their efforts, and to make modifications where needed. We propose that up to 10% of the biomass can be collected from healthy, large A. cervicornis donor colonies for nursery propagation. We also propose the following benchmarks for the first year of activities for A. cervicornis restoration: (1) >75% live tissue cover on donor colonies; (2) >80% survivorship of nursery corals; and (3) >70% survivorship of outplanted corals. Finally, we report productivity means of 4.4 cm yr-1 for nursery corals and 4.8 cm yr-1 for outplants as a frame of reference for ranking performance within programs. Such benchmarks, and potential subsequent adaptive actions, are needed to fully assess the

Evaluation of ball and roller bearings restored by grinding

Science.gov (United States)

Parker, R. J.; Zaretsky, E. V.; Chen, S. M.

1976-01-01

A joint program was undertaken to restore by grinding those rolling-element bearings which are currently being discarded at aircraft engine and transmission overhaul. Three bearing types were selected from the UH-1 helicopter engine (T-53) and transmission for the pilot program. Groups of each of these bearings were visually and dimensionally inspected for suitability for restoration. A total of 250 bearings were restored by grinding. Of this number, 30 bearings from each type were endurance tested to a TBO of 1600 hours. No bearing failures occurred related to the restoration by grinding process. The two bearing failures which occurred were due to defective rolling elements and were typical of those which may occur in new bearings. The restorable component yield to the three groups was in excess of 90 percent.

THE APPLICATION OF SURVEY IN ER WANG TEMPLE RESTITUTING

Directory of Open Access Journals (Sweden)

W. Shuai

2013-07-01

Full Text Available Er Wang Temple, in World Heritage Site "Dujiang Weirs and Qingchengshan Mountai", was severely destroyed in Wenchuan earthquake of May 2008. There are several problems at different level in every building, such as structural distortion, foundation displacement, wall fracture, roof damage, etc. The stage was completely collapsed in the earthquake. Tableland the stage situated had a huge crack and slope collapse. This article is for the stage renovation. The survey of damage in earthquake is the basis of Er Wang Temple restituting. Survey including field survey after the earthquake and the measurement and investigation for the remained construction member of the main wood structure. For field survey, the basis of pillars which had not have significantly affects in earthquake could be seem as the reference points for measurement. The investigation of remained main wood construction member, especially the size of the key structures and site and manufacture method of the joints, is the important basis for recovery stage. Our team did our utmost to restore the original appearance of stage in design, materials and craft by various tools, which include measured drawings in different times, old images collection, fine measuring by 3D laser scan, measurement of leftover pieces, logical inference.

Los Alamos National Laboratory Environmental Restoration Project quarterly technical report, April--June 1994

Energy Technology Data Exchange (ETDEWEB)

1994-08-18

This quarterly report describes the technical status of activities in the Los Alamos National Laboratory Environmental Restoration (ER) Project. Each activity is identified by an activity data sheet number, a brief title describing the activity or the technical area where the activity is located, and the name of the project leader. The Hazardous and Solid Waste Amendments (HSWA) portion of the facility operating permit requires the submission of a technical progress report on a quarterly basis. This report, submitted to fulfill the permit`s requirement, summarizes the work performed and the results of sampling and analysis in the ER Project. Suspect waste found include: Radionuclides, high explosives, metals, solvents and organics. The data provided in this report have not been validated. These data are considered ``reviewed data.``

Completion report for Well ER-EC-6

Energy Technology Data Exchange (ETDEWEB)

M. J. Townsend

2000-05-01

Well ER-EC-6 was drilled for the U.S. Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the spring of 1999 as part of the DOE's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 66-centimeter surface hole was drilled and cased off to the depth of 485.1 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,524.0 meters. A preliminary composite, static, water level was measured at the depth of approximately 434.6 meters prior to installation of the completion string. One completion string with four isolated, slotted intervals was installed in the well. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters and 33 sidewall samples taken at various depths below 504.4 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well penetrated Tertiary-age lava and tuff of the Timber Mountain Group, the Paintbrush Group, the Calico Hills Formation, and the Volcanics of Quartz Mountain. Intense hydrothermal alteration was observed below the depth of 640 m. The preliminary geologic interpretation indicates that this site may be located on a buried structural ridge that separates the Silent Canyon and Timber Mountain caldera complexes.

Er danskerne racister

DEFF Research Database (Denmark)

Bech, Henning; Necef, Mehmet Ümit

Igennem de seneste årtier er det blevet almindeligt at tale om, at der er en udbredt racisme i Danmark. Påstande om danskernes racisme, fremmedhad og diskrimination optræder dagligt i offentligheden og i medierne, og der henvises ofte til, hvad ’forskerne’ og de ’videnskabelige undersøgelser’ siger...... om emnet. Der kan da næppe heller være tvivl om, at der forekommer racistiske holdninger hos nogle danskere. Men er problemet så stort, som det gøres til i den offentlige debat? Bogen ønsker at afklare, hvorvidt der er videnskabelig dokumentation for påstandene om danskernes racisme. Den går i dybden...... med en række forskeres og eksperters udtalelser på området og præsenterer en grundig analyse af deres fremstilling af dansk racisme i forhold til emner som kultur, seksualitet, kriminalitet og arbejdsmarked....

Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death

International Nuclear Information System (INIS)

Deerberg, Andrea; Sosna, Justyna; Thon, Lutz; Belka, Claus; Adam, Dieter

2009-01-01

Programmed cell death (PCD) is essential for development and homeostasis of multicellular organisms and can occur by caspase-dependent apoptosis or alternatively, by caspase-independent PCD (ciPCD). Bcl-2, a central regulator of apoptosis, localizes to both mitochondria and the endoplasmic reticulum (ER). Whereas a function of mitochondrial and ER-specific Bcl-2 in apoptosis has been established in multiple studies, corresponding data for ciPCD do not exist. We utilized Bcl-2 constructs specifically localizing to mitochondria (Bcl-2 ActA), the ER (Bcl-2 cb5), both (Bcl-2 WT) or the cytosol/nucleus (Bcl-2 ΔTM) and determined their protective effect on ceramide-mediated ciPCD in transiently and stably transfected Jurkat cells. Expression of the constructs was verified by immunoblots. Ceramide-mediated ciPCD was induced by treatment with human recombinant tumor necrosis factor and determined by flow cytometric measurement of propidium iodide uptake as well as by optical analysis of cell morphology. Only wildtype Bcl-2 had the ability to efficiently protect from ceramide-mediated ciPCD, whereas expression of Bcl-2 solely at mitochondria, the ER, or the cytosol/nucleus did not prevent ceramide-mediated ciPCD. Our data suggest a combined requirement for both mitochondria and the ER in the induction and the signaling pathways of ciPCD mediated by ceramide

Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death

Directory of Open Access Journals (Sweden)

Belka Claus

2009-10-01

Full Text Available Abstract Background Programmed cell death (PCD is essential for development and homeostasis of multicellular organisms and can occur by caspase-dependent apoptosis or alternatively, by caspase-independent PCD (ciPCD. Bcl-2, a central regulator of apoptosis, localizes to both mitochondria and the endoplasmic reticulum (ER. Whereas a function of mitochondrial and ER-specific Bcl-2 in apoptosis has been established in multiple studies, corresponding data for ciPCD do not exist. Methods We utilized Bcl-2 constructs specifically localizing to mitochondria (Bcl-2 ActA, the ER (Bcl-2 cb5, both (Bcl-2 WT or the cytosol/nucleus (Bcl-2 ΔTM and determined their protective effect on ceramide-mediated ciPCD in transiently and stably transfected Jurkat cells. Expression of the constructs was verified by immunoblots. Ceramide-mediated ciPCD was induced by treatment with human recombinant tumor necrosis factor and determined by flow cytometric measurement of propidium iodide uptake as well as by optical analysis of cell morphology. Results Only wildtype Bcl-2 had the ability to efficiently protect from ceramide-mediated ciPCD, whereas expression of Bcl-2 solely at mitochondria, the ER, or the cytosol/nucleus did not prevent ceramide-mediated ciPCD. Conclusion Our data suggest a combined requirement for both mitochondria and the ER in the induction and the signaling pathways of ciPCD mediated by ceramide.

Dominant gain-of-function mutations in transmembrane domain III of ERS1 and ETR1 suggest a novel role for this domain in regulating the magnitude of ethylene response in Arabidopsis.

Science.gov (United States)

Deslauriers, Stephen D; Alvarez, Ashley A; Lacey, Randy F; Binder, Brad M; Larsen, Paul B

2015-10-01

Prior work resulted in identification of an Arabidopsis mutant, eer5-1, with extreme ethylene response in conjunction with failure to induce a subset of ethylene-responsive genes, including AtEBP. EER5, which is a TREX-2 homolog that is part of a nucleoporin complex, functions as part of a cryptic aspect of the ethylene signaling pathway that is required for regulating the magnitude of ethylene response. A suppressor mutagenesis screen was carried out to identify second site mutations that could restore the growth of ethylene-treated eer5-1 to wild-type levels. A dominant gain-of-function mutation in the ethylene receptor ETHYLENE RESPONSE SENSOR 1 (ERS1) was identified, with the ers1-4 mutation being located in transmembrane domain III at a point nearly equivalent to the previously described etr1-2 mutation in the other Arabidopsis subfamily I ethylene receptor, ETHYLENE RESPONSE 1 (ETR1). Although both ers1-4 and etr1-2 partially suppress the ethylene hypersensitivity of eer5-1 and are at least in part REVERSION TO ETHYLENE SENSITIVITY 1 (RTE1)-dependent, ers1-4 was additionally found to restore the expression of AtEBP in ers1-4;eer5-1 etiolated seedlings after ethylene treatment in an EIN3-dependent manner. Our work indicates that ERS1-regulated expression of a subset of ethylene-responsive genes is related to controlling the magnitude of ethylene response, with hyperinduction of these genes correlated with reduced ethylene-dependent growth inhibition. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

Sears Point Tidal Marsh Restoration Project: Phase II

Science.gov (United States)

Information about the SFBWQP Sears Point Tidal Marsh Restoration Project: Phase II, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

Project management plan for the gunite and associated tanks treatability studies project at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1995-12-01

This plan for the Gunite and Associated Tanks (GAAT) Treatability Studies Project satisfies the requirements of the program management plan for the Oak Ridge National Laboratory (ORNL) Environmental Restoration (ER) Program as established in the Program Management Plan for the Martin Marietta Energy Systems, Inc., Oak Ridge National Laboratory Site Environmental Restoration Program. This plan is a subtier of several other ER documents designed to satisfy the US Department of Energy (DOE) Order 4700.1 requirement for major systems acquisitions. This project management plan identifies the major activities of the GAAT Treatability Studies Project; establishes performance criteria; discusses the roles and responsibilities of the organizations that will perform the work; and summarizes the work breakdown structure, schedule, milestones, and cost estimate for the project

Summary of LLNL's accomplishments for the FY93 Waste Processing Operations Program

International Nuclear Information System (INIS)

Grasz, E.; Domning, E.; Heggins, D.; Huber, L.; Hurd, R.; Martz, H.; Roberson, P.; Wilhelmsen, K.

1994-04-01

Under the US Department of Energy's (DOE's) Office of Technology Development (OTD)-Robotic Technology Development Program (RTDP), the Waste Processing Operations (WPO) Program was initiated in FY92 to address the development of automated material handling and automated chemical and physical processing systems for mixed wastes. The Program's mission was to develop a strategy for the treatment of all DOE mixed, low-level, and transuranic wastes. As part of this mission, DOE's Mixed Waste Integrated Program (MWIP) was charged with the development of innovative waste treatment technologies to surmount shortcomings of existing baseline systems. Current technology advancements and applications results from cooperation of private industry, educational institutions, and several national laboratories operated for DOE. This summary document presents the LLNL Environmental Restoration and Waste Management (ER and WM) Automation and Robotics Section's contributions in support of DOE's FY93 WPO Program. This document further describes the technological developments that were integrated in the 1993 Mixed Waste Operations (MWO) Demonstration held at SRTC in November 1993

Sears Point Tidal Marsh Restoration Project: Phase I

Science.gov (United States)

Information about the SFBWQP Sears Point Tidal Marsh Restoration Project: Phase I project, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

Lessons learned bulletin

International Nuclear Information System (INIS)

1994-05-01

During the past four years, the Department of Energy -- Savannah River Operations Office and the Westinghouse Savannah River Company (WSRC) Environmental Restoration (ER) Program completed various activities ranging from waste site investigations to closure and post closure projects. Critiques for lessons learned regarding project activities are performed at the completion of each project milestone, and this critique interval allows for frequent recognition of lessons learned. In addition to project related lessons learned, ER also performs lessons learned critiques. T'he Savannah River Site (SRS) also obtains lessons learned information from general industry, commercial nuclear industry, naval nuclear programs, and other DOE sites within the complex. Procedures are approved to administer the lessons learned program, and a database is available to catalog applicable lessons learned regarding environmental remediation, restoration, and administrative activities. ER will continue to use this database as a source of information available to SRS personnel

Den sproglige leg er super fly

DEFF Research Database (Denmark)

Just, Sine Nørholm

2013-01-01

Man kan rappe om alt. I hvert fald hvis man er Marvelous Mosell. I spændingsfeltet mellem fiktion og virkelighed skaber Mosell sin persona i et forjættende 80' er-univers der på en og samme tid er vildt overdrevet og helt autentisk.......Man kan rappe om alt. I hvert fald hvis man er Marvelous Mosell. I spændingsfeltet mellem fiktion og virkelighed skaber Mosell sin persona i et forjættende 80' er-univers der på en og samme tid er vildt overdrevet og helt autentisk....

SYP73 Anchors the ER to the Actin Cytoskeleton for Maintenance of ER Integrity and Streaming in Arabidopsis.

Science.gov (United States)

Cao, Pengfei; Renna, Luciana; Stefano, Giovanni; Brandizzi, Federica

2016-12-05

The endoplasmic reticulum (ER) is an essential organelle that spreads throughout the cytoplasm as one interconnected network of narrow tubules and dilated cisternae that enclose a single lumen. The ER network undergoes extensive remodeling, which critically depends on membrane-cytoskeleton interactions [1]. In plants, the ER is also highly mobile, and its streaming contributes significantly to the movement of other organelles [2, 3]. The remodeling and motility of the plant ER rely mainly on actin [4] and to a minor extent on microtubules [5]. Although a three-way interaction between the ER, cytosolic myosin-XI, and F-actin mediates the plant ER streaming [6], the mechanisms underlying stable interaction of the ER membrane with actin are unknown. Early electron microscopy studies suggested a direct attachment of the plant ER with actin filaments [7, 8], but it is plausible that yet-unknown proteins facilitate anchoring of the ER membrane with the cytoskeleton. We demonstrate here that SYP73, a member of the plant Syp7 subgroup of SNARE proteins [9] containing actin-binding domains, is a novel ER membrane-associated actin-binding protein. We show that overexpression of SYP73 causes a striking rearrangement of the ER over actin and that, similar to mutations of myosin-XI [4, 10, 11], loss of SYP73 reduces ER streaming and affects overall ER network morphology and plant growth. We propose a model for plant ER remodeling whereby the dynamic rearrangement and streaming of the ER network depend on the propelling action of myosin-XI over actin coupled with a SYP73-mediated bridging, which dynamically anchors the ER membrane with actin filaments. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Oncor Geodatabase for the Columbia Estuary Ecosystem Restoration Program: Annual Report, 2012

Energy Technology Data Exchange (ETDEWEB)

Coleman, Andre M.; Johnson, Gary E.; Borde, Amy B.; Diefenderfer, Heida L.; Sather, Nichole K.; Seiple, Timothy E.; Serkowski, John A.

2013-11-10

Pacific Northwest National Laboratory (PNNL) conducted this project for the U.S. Army Corps of Engineers, Portland District (Corps). The purpose of the project is to develop a geospatial, web-accessible database (called “Oncor”) for action effectiveness and related data from monitoring and research efforts for the Columbia Estuary Ecosystem Restoration Program (CEERP). The intent is for the Oncor database to enable synthesis and evaluation, the results of which can then be applied in subsequent CEERP decision-making. This is the first annual report in what is expected to be a 3- to 4-year project, which commenced on February 14, 2012.

The UMTRA PEIS: A strategy for groundwater remediation

International Nuclear Information System (INIS)

Burt, C.; Ulland, L.; Weston, R.F.; Metzler, D.

1993-01-01

A programmatic environmental impact statement (PEIS) was initiated in 1992 for the uranium mill tailings remedial action (UMTRA) program. The PEIS kicked off the groundwater restoration phase of UMTRA, a project involving remediation of 24 sites in ten states and tribal lands contaminated with tailings from uranium mining and milling operations. The U.S. Department of Energy (DOE) agreed, in early 1992, that a PEIS was an appropriate strategy to comply with the National Environmental Policy Act (NEPA) for this second, groundwater phase of the project. This decision recognized that although a parallel effort was being undertaken in preparing a PEIS for DOE's Environmental Restoration/Waste Management (ER/WM) program, characteristics and the maturity of the UMTRA project made it more appropriate to prepare a separate PEIS. The ER/WM PEIS is intended to examine environmental restoration and waste management issues from a very broad perspective. For UMTRA, with surface remediation completed or well under way at 18 of the 24 sites, a more focused programmatic approach for groundwater restoration is more effective than including the UMTRA project within the ER/WM environmental impact statements. A separate document allows a more focused and detailed analysis necessary to efficiently tier site-specific environmental assessments for groundwater restoration at each of the 24 UMTRA former processing sites

A Controlled and Retrospective Study of 144 Chronic Low Back Pain Patients to Evaluate the Effectiveness of an Intensive Functional Restoration Program in France

Directory of Open Access Journals (Sweden)

Isabelle Caby

2016-04-01

Full Text Available Study Design: A controlled and retrospective study of 144 chronic low back pain patients to evaluate the effectiveness of an intensive functional restoration program in France. Objective: Evaluating the efficiency of an intensive, dynamic and multidisciplinary functional restoration program in patients with chronic low back pain (LBP, during 6 and 12 months follow up. Summary of background data: Chronic low back pain disease has a multifactor nature, involving physical, psychological professional and social factors. A functional restoration program (FRP has been included in a multidisciplinary training program which provides an efficient therapeutic solution. However, the effectiveness of an FRP has not been yet established. Methods: 144 subjects (71 males, 73 females with chronic low back pain were included in a functional restoration program. The FRP includes physiotherapy and occupational therapy interventions together with psychological counselling. Patients participated as in- or outpatients 6 h per day, 5 days a week over 5 weeks. Pain intensity, trunk flexibility, trunk strength, lifting ability, quality of life and return to work were recorded before, immediately after, and at 6 months and 12 months after the treatment period. Results: All outcome measures were significantly higher just after the FRP (144 patients and at 6 and 12 months (from available data in 31 subjects compared to pre-treatment values. This FRP for chronic low back pain maintained its benefits whatever the patient’s activities. Conclusions: The effects reflected on all outcome measures, both on short and long term follow-up. The multidisciplinary FRP for chronic low back pain patients durably stopped the de-conditioning syndrome and involved new life-style habits for the patient, daily pain management and a return to work.

Quantifying the "So what?" of Restoration: A Framework for Evaluating the Ecological and Socio-economic Outcomes of Restoration Activities in the Gulf of Mexico

Science.gov (United States)

Henkel, J. R.; Dausman, A.; Cowan, J.; Sutter, B.

2017-12-01

Healthy and sustainable ecosystems are essential for thriving and resilient coastal communities. As a result of settlements following the Deepwater Horizon oil spill, the Gulf Coast Ecosystem Restoration Council (Council) and other funding entities, will receive billions of dollars over the next 15 years for restoration projects and programs. These and future restoration efforts present an opportunity to improve the function of coastal wetlands in the Gulf of Mexico, and potentially address long-standing barriers to ecosystem health and resilience in the region. In its Comprehensive Plans, the Council has committed to science-based decision-making, collaboration among its eleven state and federal members, and close coordination with other Gulf restoration and conservation funding efforts including NRDA, NFWF and other federal programs to leverage resources and integrate complementary restoration efforts. To help fulfill these commitments the Council is exploring methods and tools to collect and assess data to evaluate and report on both ecological and socio-economic outcomes of restoration projects. Application of these tools in coordination with restoration partners, will demonstrate the cascading benefits of ecosystem restoration in a quantifiable way, and can help decision-makers increase investments in ecosystem restoration that will support the long-term sustainability of coastal systems. An understanding of ecosystem function and services can also provide a transparent lens for communicating the results of successful ecosystem restoration projects to the public (helping answer the "So what?" of ecosystem restoration). As the Council moves forward making decisions based on the best available science, improving ecosystem functioning and services will play a role in project and program selection and will result in more resilient ecosystems. This will enable the Council to help communities enhance their ability to recover from natural and manmade disasters and

Effect of type of cavity preparation (bur,Er:YAG laser) and restorative materials on prevention of caries lesion

OpenAIRE

Masumeh Hasani Tabatabaei; Sakineh Arami; Fatemeh Khajavi; Zohreh Moradi

2017-01-01

Background and Aims: Despite the reduction of incidence of dental caries in recent years, this disease is common and many efforts were conducted to decrease the prevalence of dental caries. On the other hand secondary caries lesions are the main reason for replacement of direct restorations. Therefore, the aim of the current study was to evaluate suitable methods of preparation and restorative materials to reduce caries recurrence. Materials and Methods: In this experimental study, eighty...

Completion Report for the Well ER-6-2 Site Corrective Action Unit 97: Yucca Flat - Climax Mine

International Nuclear Information System (INIS)

2008-01-01

Well ER-6-2 and its satellite hole, Well ER-6-2 No.1, were drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. Well ER-6-2 was drilled in two stages in 1993 and 1994; the satellite hole, Well ER-6-2 No.1 was drilled nearby in 1993 but was abandoned. The wells were drilled as part of a hydrogeologic investigation program for the Yucca Flat-Climax Mine Corrective Action Unit Number 97, in the northeastern portion of the Nevada Test Site. The wells are located in Yucca Flat, within Area 6 of the Nevada Test Site. The wells provided information regarding the radiological and hydrogeological environment in a potentially down-gradient position from tests conducted in northern and central Yucca Flat. Construction of Well ER-6-2 began with a 1.2-meter-diameter surface conductor hole, which was drilled and cased off to a depth of 30.8 meters below the surface. A 50.8-centimeter diameter surface hole was then rotary drilled to the depth of 578.5 meters and cased off to the depth of 530.4 meters. The hole diameter was then reduced to 27.0 centimeters, and the borehole was advanced to a temporary depth of 611.4 meters. The borehole was conventionally cored to a total depth of 1,045 meters with a diameter of 14.0 centimeters. Borehole sloughing required cementing and re-drilling of several zones. The open-hole completion accesses the lower carbonate aquifer, the CP thrust fault, and the upper clastic confining unit. A fluid level depth of 543.2 meters was most recently measured in the open borehole in September 2007. No radionuclides were encountered during drilling. The satellite hole Well ER-6-2 No.1 was drilled approximately 15.2 meters north of Well ER-6-2 on the same drill pad. This was planned to be used as an observation well during future hydrologic testing at Well ER-6-2; however, the satellite hole was abandoned at

Source document for waste area groupings at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Osborne, P.L.; Kuhaida, A.J., Jr.

1996-09-01

This document serves as a source document for Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and other types of documents developed for and pertaining to Environmental Restoration (ER) Program activities at Oak Ridge National Laboratory (ORNL). It contains descriptions of the (1) regulatory requirements for the ORR ER Program, (2) Oak Ridge Reservation (ORR) ER Program, (3) ORNL site history and characterization, and (4) history and characterization of Waste Area Groupings (WAGS) 1-20. This document was created to save time, effort, and money for persons and organizations drafting documents for the ER Program and to improve consistency in the documents prepared for the program. By eliminating the repetitious use of selected information about the program, this document will help reduce the time and costs associated with producing program documents. By serving as a benchmark for selected information about the ER Program, this reference will help ensure that information presented in future documents is accurate and complete

Site of Er ions in silica layers codoped with Si nanoclusters and Er

International Nuclear Information System (INIS)

Pellegrino, P.; Garrido, B.; Arbiol, J.; Garcia, C.; Lebour, Y.; Morante, J.R.

2006-01-01

Silica layers implanted with Si and Er ions to various doses and annealed at 950 deg. C have been investigated by means of energy-filtered transmission electron microscopy (EFTEM) and high annular angle dark field (HAADF). EFTEM analysis reveals Si nanoclusters (Si-nc) with an average size around 3 nm for high Si content (15 at. %) whereas no clusters can be imaged for the lowest Si excess (5 at. %). Raman scattering supports that amorphous Si precipitates are present in all the samples. Moreover, the filtered images show that Er ions appear preferentially located outside the Si-nc. HAADF analysis confirms that the Er atoms form agglomerations of 5-10 nm size when the Er concentration exceeds 1x10 20 cm -3 . This observation correlates well with the reduction of the Er population excitable by Si nanoclusters, in the best case corresponding to 10% of the total. A suitable tuning of the annealing drastically reduces this deleterious effect

Computational modelling of Er(3+): Garnet laser materials

Science.gov (United States)

Spangler, Lee H.

1994-01-01

The Er(3+) ion has attracted a lot of interest for four reasons: (1) Its (4)I(sub 13/2) yields (4)I(sub 15/2) transition lases in the eyesafe region near 1.5 micron; (2) the (4)I(sub 13/2) transition lases near 2.8 micron, an important wavelength for surgical purposes; (3) it displays surprisingly efficient upconversion with lasing observed at 1.7, 1.2, 0.85, 0.56, 0.55, and 0.47 micron following 1.5 micron pumping; and (4) it has absorption bands at 0.96 and 0.81 micron and thus can be diode pumped. However, properties desirable for upconversion reduce the efficiency of 1.5 and 3 micron laser operation and vice versa. Since all of the processes are influenced by the host via the crystal field induced stark splittings in the Er levels, this project undertook modelling of the host influence on the Er lasinng behavior. While growth and measurement of all ten Er(3+) doped garnets is the surest way of identifying hosts which maximize upconversion (or conversly, 1.5 and 3 micron performance), it is also expensive - costing approximately $10,000/material or approximately $100,000 for the materials computationally investigated here. The calculations were performed using a quantum mechanical point charge model developed by Clyde Morrison at Harry Diamond Laboratories. The programs were used to fit the Er:YAG experimental energy levels so that the crystal field parameters, B(sub nm) could be extracted. From these radial factors, rho (sub n) were determined for Er(3+) in garnets. These, in combination with crystal field components, Anm, available from X-ray data, were used to predict energy levels for Er in the other nine garnet hosts. The levels in Er:YAG were fit with an rms error of 12.2/cm over a 22,000/cm range. Predicted levels for two other garnets for which literature values were available had rms errors of less than 17/cm , showing the calculations to be reliable. Based on resonances between pairs of calculated stark levels, the model predicts GSGG as the best host

On-site laboratory support of Oak Ridge National Laboratory environmental restoration field activities

International Nuclear Information System (INIS)

Burn, J.L.E.

1995-07-01

A remedial investigation/feasibility study has been undertaken at Oak Ridge National Laboratory (ORNL). Bechtel National, Inc. and partners CH2M Hill, Ogden Environmental and Energy Services, and PEER Consultants are contracted to Lockheed Martin Energy Systems, performing this work for ORNL's Environmental Restoration (ER) Program. An on-site Close Support Laboratory (CSL) established at the ER Field Operations Facility has evolved into a laboratory where quality analytical screening results can be provided rapidly (e.g., within 24 hours of sampling). CSL capabilities include three basic areas: radiochemistry, chromatography, and wet chemistry. Radiochemical analyses include gamma spectroscopy, tritium and carbon-14 screens using liquid scintillation analysis, and gross alpha and beta counting. Cerenkov counting and crown-ether-based separation are the two rapid methods used for radiostrontium determination in water samples. By extending count times where appropriate, method detection limits can match those achieved by off-site contract laboratories. Volatile organic compounds are detected by means of gas chromatography using either headspace or purge and trap sample introduction (based on EPA 601/602). Ionic content of water samples is determined using ion chromatography and alkalinity measurement. Ion chromatography is used to quantify both anions (based on EPA 300) and cations. Wet chemistry procedures performed at the CSL include alkalinity, pH (water and soil), soil resistivity, and dissolved/suspended solids. Besides environmental samples, the CSL routinely screens health and safety and waste management samples. The cost savings of the CSL are both direct and indirect

Rouw mag er zijn

Directory of Open Access Journals (Sweden)

Marlieke Moors

2015-12-01

Full Text Available ABSTRACTGrieving is allowedGrief is a human experience. Every form of loss shapes you into the human being you are today. Contrary to what earlier, unproven grief models postulate, grief does not have an end point. That is, bereavement does not have to be completely processed, but it should be integrated into someone’s life. The outdated grief models were often interpreted and used in a normative way, which led to a normative standard model. This portraits the belief that every mourner would experience similar symptoms and would go through a fixed pattern of phases. However, the updated vision emphasizes the individual and unique process of coping with loss: norms concerning grief should be banned. By means of literature research, interviews with professionals and personal experiences, it became clear that finding an equilibrium between restoration-orientated and loss-orientated coping styles is most beneficial. An important aspect in finding this balance is meaningfulness. Furthermore, the ability to bear a loss and to adapt accordingly are important components. Lastly, attaching significance to a loss is a constructive way of integrating the loss into one’s life. The death of a loved one should therefore not be forgotten or tucked away. After all, grief is the price we pay for love. SAMENVATTINGRouw mag er zijnRouw is een menselijke ervaring en elk verlies vormt je als mens. Rouw heeft, in tegenstelling tot wat de verouderde, niet bewezen rouwmodellen beweren, geen eindpunt. Verlies hoeft namelijk niet verwerkt te worden, maar moet juist geïntegreerd worden in iemands leven. De verouderde rouwmodellen zijn vaak normatief opgevat en toegepast, waaruit een normatief standaardmodel is ontstaan. Daarbij werd gedacht dat elke rouwende dezelfde symptomen zou vertonen en het rouwproces volgens vaste fasen zou verlopen. Binnen de vernieuwde visie wordt er juist van uitgegaan dat elk individu een unieke manier van reageren op rouw heeft. Er zou

A Comparative Study of Er3+, Er3+-Eu3+, Er3+-Tb3+, and Er3+-Eu3+-Tb3+ Codoped Y2O3 Nanoparticles as Optical Heaters

Directory of Open Access Journals (Sweden)

G. A. Sobral

2015-01-01

Full Text Available Fluorescence intensity ratio (FIR technique, based on the thermal coupling of H11/22 and S3/24 energy levels of erbium ions, was used to study the optical heating behavior of rare earth doped yttrium oxide nanophosphors (Y2O3:Er3+, Y2O3:Er3+-Eu3+, Y2O3:Er3+-Tb3+, and Y2O3:Er3+-Eu3+-Tb3+ synthesized via PVA-assisted sol-gel route. The samples were optically heated by an 800 nm CW diode laser, while the upconverted green emissions were used to measure their temperatures in real time. The experimental results indicate that the studied nanoparticles are promising candidates to applications such as photothermal treatments and hyperthermia.

Fluxus-øer

DEFF Research Database (Denmark)

van der Meijden, Peter Alexander

2008-01-01

"Fluxus-øer" er en introduktion til Fluxus med udgangspunkt i den tyske galleri-ejer René Blocks samling, som udstillingen "Food for Thought" i Sukkerfabrikken i Stege (Møn) præsenterede et udvalg af. Artiklen beskriver Fluxus som et heterotopi som beskrevet af Michel Foucault i "Of Other Spaces"...

Improved functional capacity evaluation performance predicts successful return to work one year after completing a functional restoration rehabilitation program.

Science.gov (United States)

Fore, Lisa; Perez, Yoheli; Neblett, Randy; Asih, Sali; Mayer, Tom G; Gatchel, Robert J

2015-04-01

To evaluate whether functional capacity evaluation (FCE) scores are responsive to functional restoration treatment, and to assess the ability of FCEs at program discharge to predict work outcomes. An interdisciplinary cohort study of prospectively collected data. A functional restoration center. A consecutive sample of 354 patients with chronic disabling occupational musculoskeletal disorders (CDOMDs) completed a functional restoration program consisting of quantitatively directed exercise progression and multi-modal disability management with interdisciplinary medical supervision. Each patient participated in an FCE at admission and discharge from treatment. The results of each FCE yielded the physical demand level (PDL) at which patients were functioning. Patients were initially divided into 5 PDL groups, based on job-of-injury lifting, carrying, and pushing/pulling requirements, for the pre- to posttreatment responsiveness analyses. Patients were subsequently divided into 5 PDL groups, based on their performance on the FCE upon program completion. Outcome measures included admission-to-discharge changes in PDLs and 2 specific FCE lifting tasks: isokinetic lifting; and the Progressive Isoinertial Lifting Evaluation (PILE). Socioeconomic outcomes were also evaluated, including post-discharge work return and work retention 1-year after treatment completion. Overall, 96% of the patients demonstrated improvement in their PDLs from admission to discharge. A majority of patients (56%) were able to achieve a discharge PDL that was comparable to their estimated job-of-injury lifting requirement or higher (P work return (P work retention (P work return after treatment completion and work retention 1 year later. Copyright © 2015 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity.

Science.gov (United States)

Kim, G W; Lin, J E; Snook, A E; Aing, A S; Merlino, D J; Li, P; Waldman, S A

2016-05-23

The uroguanylin-GUCY2C gut-brain axis has emerged as one component regulating feeding, energy homeostasis, body mass and metabolism. Here, we explore a role for this axis in mechanisms underlying diet-induced obesity (DIO). Intestinal uroguanylin expression and secretion, and hypothalamic GUCY2C expression and anorexigenic signaling, were quantified in mice on high-calorie diets for 14 weeks. The role of endoplasmic reticulum (ER) stress in suppressing uroguanylin in DIO was explored using tunicamycin, an inducer of ER stress, and tauroursodeoxycholic acid (TUDCA), a chemical chaperone that inhibits ER stress. The impact of consumed calories on uroguanylin expression was explored by dietary manipulation. The role of uroguanylin in mechanisms underlying obesity was examined using Camk2a-Cre-ER(T2)-Rosa-STOP(loxP/loxP)-Guca2b mice in which tamoxifen induces transgenic hormone expression in brain. DIO suppressed intestinal uroguanylin expression and eliminated its postprandial secretion into the circulation. DIO suppressed uroguanylin through ER stress, an effect mimicked by tunicamycin and blocked by TUDCA. Hormone suppression by DIO reflected consumed calories, rather than the pathophysiological milieu of obesity, as a diet high in calories from carbohydrates suppressed uroguanylin in lean mice, whereas calorie restriction restored uroguanylin in obese mice. However, hypothalamic GUCY2C, enriched in the arcuate nucleus, produced anorexigenic signals mediating satiety upon exogenous agonist administration, and DIO did not impair these responses. Uroguanylin replacement by transgenic expression in brain repaired the hormone insufficiency and reconstituted satiety responses opposing DIO and its associated comorbidities, including visceral adiposity, glucose intolerance and hepatic steatosis. These studies reveal a novel pathophysiological mechanism contributing to obesity in which calorie-induced suppression of intestinal uroguanylin impairs hypothalamic mechanisms

Effect of the unfolded protein response on ER protein export: a potential new mechanism to relieve ER stress.

Science.gov (United States)

Shaheen, Alaa

2018-05-05

The unfolded protein response (UPR) is an adaptive cellular response that aims to relieve endoplasmic reticulum (ER) stress via several mechanisms, including inhibition of protein synthesis and enhancement of protein folding and degradation. There is a controversy over the effect of the UPR on ER protein export. While some investigators suggested that ER export is inhibited during ER stress, others suggested the opposite. In this article, their conflicting studies are analyzed and compared in attempt to solve this controversy. The UPR appears indeed to enhance ER export, possibly via multiple mechanisms. However, another factor, which is the integrity of the folding machinery/environment inside ER, determines whether ER export will appear increased or decreased during experimentation. Also, different methods of stress induction appear to have different effects on ER export. Thus, improvement of ER export may represent a new mechanism by which the UPR alleviates ER stress. This may help researchers to understand how the UPR works inside cells and how to manipulate it to alter cell fate during stress, either to promote cell survival or death. This may open up new approaches for the treatment of ER stress-related diseases.

Does the adhesive strategy influence the post-operative sensitivity in adult patients with posterior resin composite restorations?: A systematic review and meta-analysis.

Science.gov (United States)

Reis, Alessandra; Dourado Loguercio, Alessandro; Schroeder, Marcos; Luque-Martinez, Issis; Masterson, Danielle; Cople Maia, Lucianne

2015-09-01

A systematic review and meta-analysis were performed on the risk and intensity of postoperative sensitivity (POS) in posterior resin composite restorations bonded with self-etch (SE) and etch-and-rinse (ER) adhesives. A comprehensive search was performed in the MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO and Cochrane Library and SIGLE without restrictions. The abstracts of the annual conference of the IADR (1990-2014), unpublished and ongoing trials registry were also searched. Dissertations and theses were searched using the ProQuest Dissertations and Periodicos Capes Theses databases. We included randomized clinical trials that compared the clinical effectiveness of SE and ER used for direct resin composite restorations in permanent dentition of adult patients. The risk/intensity of POS was the primary outcome. The risk of bias tool of the Cochrane Collaboration was used. The meta-analysis was performed on the studies considered 'low' risk of bias. After duplicates removal, 2600 articles were identified but only 29 remained in the qualitative synthesis. Five were considered to be 'high' risk of bias and eleven were considered to be 'unclear' in the key domains, yielding 13 studies for meta-analysis. The overall relative risk of the spontaneous POS was 0.63 (95% CI 0.35 to 1.15), while the stimuli-induced POS was 0.99 (95% CI 0.63 to 1.56). The overall standardized mean difference was 0.08 (95%CI -0.19 to 0.35). No overall effect was revealed in the meta-analyses, meaning that no influence of the ER or SE strategy on POS. The type of adhesive strategy (ER or SE) for posterior resin composite restorations does not influence the risk and intensity of POS. CRD42014006617. Copyright © 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone.

Science.gov (United States)

Khadir, Abdelkrim; Kavalakatt, Sina; Abubaker, Jehad; Cherian, Preethi; Madhu, Dhanya; Al-Khairi, Irina; Abu-Farha, Mohamed; Warsame, Samia; Elkum, Naser; Dehbi, Mohammed; Tiss, Ali

2016-09-01

Perturbation of the endoplasmic reticulum (ER) homeostasis has emerged as one of the prominent features of obesity and diabetes. This occurs when the adaptive unfolded protein response (UPR) fails to restore ER function in key metabolic tissues. We previously reported increased inflammation and impaired heat shock response (HSR) in obese human subjects that were restored by physical exercise. Here, we investigated the status of ER stress chaperone; glucose-regulated protein 78 (GRP78) and its downstream UPR pathways in human obese, and their modulation by a supervised 3-month physical exercise. Subcutaneous adipose tissue (SAT) and blood samples were collected from non-diabetic adult human lean (n=40) and obese (n=40, at baseline and after 3months of physical exercise). Transcriptomic profiling was used as a primary screen to identify differentially expressed genes and it was carried out on SAT samples using the UPR RT(2) Profiler PCR Array. Conventional RT-PCR, immunohistochemistry, immunofluorescence, Western blot and ELISA were used to validate the transcriptomic data. Correlation analyses with the physical, clinical and biochemical outcomes were performed using Pearson's rank correlation coefficient. Levels of GRP78 and its three downstream UPR arms; activating transcription factor-6 (ATF6), inositol-requiring enzyme-1α (IRE1α) and protein kinase RNA-like endoplasmic reticulum kinase (PERK) were increased in obese subjects. More interestingly, higher levels of circulating GRP78 protein were found in obese compared to lean subjects which correlated negatively with maximum oxygen uptake (VO2 Max) but positively with high-sensitivity C-reactive protein (hsCRP) and obesity indicators such as BMI, percentage body fat (PBF) and waist circumference. GRP78 increased secretion in obese was further confirmed in vitro using 3T3-L1 preadipocyte cells under ER stress. Finally, we showed that physical exercise significantly attenuated the expression and release of GRP78

A summary of the environmental restoration program retrieval demonstration project at the Idaho National Engineering Laboratory

International Nuclear Information System (INIS)

McQuary, J.

1991-02-01

This report provides a summary of the Environmental Restoration Program's Retrieval Demonstration Project at the Idaho National Engineering Laboratory. This project developed concepts for demonstrating facilities and equipment for the retrieval of buried transuranic mixed waste at the INEL. Included is a brief assessment of the viability, cost effectiveness, and safety of retrieval based on the developed concept. Changes made in Revision 1 reflect editorial changes only. 31 refs., 1 fig

Supervision og de tre k´er

DEFF Research Database (Denmark)

Schilling, Benedicte; Jacobsen, Claus Haugaard; Nielsen, Jan

2010-01-01

Kontrol, kontrakt og kontekst er supervisionens tre k'er. Men hvad er supervision i det hele taget for en størrelse, der spillerså central en rolle for den psykologfaglige profession?......Kontrol, kontrakt og kontekst er supervisionens tre k'er. Men hvad er supervision i det hele taget for en størrelse, der spillerså central en rolle for den psykologfaglige profession?...

A consolidated and standardized relational database for ER data

International Nuclear Information System (INIS)

Zygmunt, B.C.

1995-01-01

The three US Department of Energy (DOE) installations on the Oak Ridge Reservation (ORR) (Oak Ridge National Laboratory, Y-12, and K-25) were established during World War II as part of the Manhattan Project that ''built the bomb.'' That research, and work in more recent years, has resulted in the generation of radioactive materials and other toxic wastes. Lockheed Martin Energy Systems manages the three Oak Ridge installations (as well as the Environmental Restoration (ER) programs at the DOE plants in Portsmouth, Ohio, and Paducah, Kentucky). DOE Oak Ridge Operations has been mandated by federal and state agreements to provide a consolidated repository of environmental data and is tasked to support environmental data management activities at all five installations. The Oak Ridge Environmental Information System (OREIS) was initiated to fulfill these requirements. The primary use of OREIS data is to provide access to project results by regulators. A secondary use is to serve as background data for other projects. This paper discusses the benefits of a consolidated and standardized database; reasons for resistance to the consolidation of data; implementing a consolidated database, including attempts at standardization, deciding what to include in the consolidated database, establishing lists of valid values, and addressing quality control (QC) issues; and the evolution of a consolidated database, which includes developing and training a user community, dealing with configuration control issues, and incorporating historical data. OREIS is used to illustrate these topics

Multiple factors influence the vegetation composition of Southeast U.S. wetlands restored in the Wetlands Reserve Program

Science.gov (United States)

Diane De Steven; Joel M. Gramling

2013-01-01

Degradation of wetlands on agricultural lands contributes to the loss of local or regional vegetation diversity. The U.S. Department of Agriculture’s Wetlands Reserve Program (WRP) funds the restoration of degraded wetlands on private ‘working lands’, but these WRP projects have not been studied in the Southeast United States. Wetland hydrogeomorphic type influences...

Art in cancer care: Exploring the role of visual art-making programs within an Energy Restoration Framework.

Science.gov (United States)

Kirshbaum, Marilynne N; Ennis, Gretchen; Waheed, Nasreena; Carter, Fiona

2017-08-01

In contrast to art-therapy, little is known about the role of art-making for people who have been diagnosed with cancer, and even less is known about program-based art-making. This study explored the experience of participation in a visual art-making program for people during and after cancer treatment in the Northern Territory of Australia. A longitudinal, qualitative, single cohort study was undertaken. Eight women diagnosed with breast and/or ovarian cancer participated in weekly art-making sessions over eight weeks, facilitated by two professional artists. Data were collected before, during and after the sessions by interviews and group discussions. The Energy Restoration Framework was used to document and analyse the benefits of participation in terms of the a priori themes of: Expansive, Belonging, Nurturing and Purposeful. The four a priori themes were retained and an additional attribute of an energy restoration activity called Stimulating was added, along with sub-themes, which broadened and deepened understanding of the art-making experience within cancer care. Involvement in an activity that was expansive, new, beautiful and fascinating was highly valued in addition to the appreciation for being with and belonging to a supportive and accepting group facilitated by dynamic artists. There is much scope for continued research and promotion of art-making programs as an adjunct to cancer treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

Shared visions, future challenges: a case study of three Collaborative Forest Landscape Restoration Program locations

Directory of Open Access Journals (Sweden)

Emily H. Walpole

2017-06-01

Full Text Available The USDA Forest Service is encouraging the restoration of select forest ecosystems through its Collaborative Forest Landscape Restoration Program (CFLRP. Collaboration is often necessary to implement landscape-scale management projects such as these, and a substantial body of research has examined the benefits and limitations of using collaboration as a tool for improving relationships, trust, and other outcomes among stakeholder groups. However, limited research has investigated the use of collaboration to achieve large-scale ecological restoration goals. Restoration poses some unique conditions for a collaborative approach, including reaching agreement on which historic conditions to use as a reference point, the degree of departure from these reference conditions that warrants management intervention, and how to balance historic conditions with expected future conditions and current human uses of the landscape. Using a mental-models approach, semistructured interviews were conducted with a total of 25 participants at three CFLRP sites. Results indicate that collaboration contributed to improved relationships and trust among participants, even among stakeholder groups with a history of disagreement over management goals. In addition, a shared focus on improving ecosystem resilience helped groups to address controversial management topics such as forest thinning in some areas. However, there was also evidence that CFLRP partnerships in our study locations have primarily focused on areas of high agreement among their stakeholders to date, and have not yet addressed other contentious topics. Previous studies suggest that first conducting management in areas with high consensus among participating stakeholders can build relationships and advance long-term goals. Nonetheless, our results indicate that achieving compromise in less obviously departed systems will require more explicit value-based discussions among stakeholders.

Effect of different provisional cement remnant cleaning procedures including Er:YAG laser on shear bond strength of ceramics

OpenAIRE

Zortuk, Mustafa; Gumus, Hasan Onder; Kilinc, Halil Ibrahim; Tuncdemir, Ali Riza

2012-01-01

PURPOSE The purpose of this study was to evaluate the effect of provisional cement removal by different dentin cleaning protocols (dental explorer, pumice, cleaning bur, Er:YAG laser) on the shear bond strength between ceramic and dentin. MATERIALS AND METHODS In total, 36 caries-free unrestored human third molars were selected as tooth specimens. Provisional restorations were fabricated and cemented with eugenol-free provisional cement. Then, disc-shaped ceramic specimens were fabricated and...

Environmental Restoration 1997 annual report

International Nuclear Information System (INIS)

Cosper, M.B.

1997-01-01

During 1997, the Environmental Restoration Program at the Savannah River Site achieved all of the ''Breakthrough Goals'' that were established with the regulatory agencies in 1995 to advance their cleanup efforts. Effective focus on field remediation was demonstrated by the allocation of 75% of program funding to remediation activities. The Remediation Phase is complete or has begun on sixty-nine waste sites that represent approximately 80% of the known environmental and health risk. The average time required for the assessment phase of active projects was reduced by 50%, from 49 to less than 24 months, which allows cleanup actions to start twice as fast as before. Breakthrough performance has tangible results. During 1997, all of the funding allocation was used effectively to accomplish environmental restoration scope worth over $123 million. That represents a validated cost efficiency of over 20% for the third straight year. Over half of the 500 contaminated acres at SRS have been cleaned up or are currently in the remediation phase. Almost 3 billion gallons of groundwater have been restored by removing over half a million pounds of organic solvents

ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players.

Science.gov (United States)

Bahar, Entaz; Kim, Hyongsuk; Yoon, Hyonok

2016-09-15

The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular activities and survival. Disturbances in the normal ER functions lead to the accumulation and aggregation of unfolded proteins, which initiates an adaptive response, the unfolded protein response (UPR), in order to regain normal ER functions. Failure to activate the adaptive response initiates the process of programmed cell death or apoptosis. Apoptosis plays an important role in cell elimination, which is essential for embryogenesis, development, and tissue homeostasis. Impaired apoptosis can lead to the development of various pathological conditions, such as neurodegenerative and autoimmune diseases, cancer, or acquired immune deficiency syndrome (AIDS). Calcium (Ca(2+)) is one of the key regulators of cell survival and it can induce ER stress-mediated apoptosis in response to various conditions. Ca(2+) regulates cell death both at the early and late stages of apoptosis. Severe Ca(2+) dysregulation can promote cell death through apoptosis. Action potential, an electrical signal transmitted along the neurons and muscle fibers, is important for conveying information to, from, and within the brain. Upon the initiation of the action potential, increased levels of cytosolic Ca(2+) (depolarization) lead to the activation of the ER stress response involved in the initiation of apoptosis. In this review, we discuss the involvement of Ca(2+) and action potential in ER stress-mediated apoptosis.

From State-controlled to Polycentric Governance in Forest Landscape Restoration: The Case of the Ecological Forest Purchase Program in Yong'an Municipality of China.

Science.gov (United States)

Long, Hexing; Liu, Jinlong; Tu, Chengyue; Fu, Yimin

2018-07-01

Forest landscape restoration is emerging as an effective approach to restore degraded forests for the provision of ecosystem services and to minimize trade-offs between conservation and rural livelihoods. Policy and institutional innovations in China illustrate the governance transformation of forest landscape restoration from state-controlled to polycentric governance. Based on a case study of the Ecological Forest Purchase Program in Yong'an municipality, China's Fujian Province, this paper explores how such forest governance transformation has evolved and how it has shaped the outcomes of forest landscape restoration in terms of multi-dimensionality and actor configurations. Our analysis indicates that accommodating the participation of multiple actors and market-based instruments facilitate a smoother transition from state-centered to polycentric governance in forest landscape restoration. Governance transitions for forest landscape restoration must overcome a number of challenges including ensurance of a formal participation forum, fair participation, and a sustainable legislative and financial system to enhance long-term effectiveness.

Er HR ude i tovene?

DEFF Research Database (Denmark)

Poulfelt, Flemming

2015-01-01

HR: Er der behov for nytænkning i HR-land? Artikler i Harvard Business Review - bakket op af en dansk undersøgelse - konkluderer, at HR stadig mangler gennemslagskraft i virksomhederne. Er HR ude i tovene? ... For i undersøgelsen "Ny Dansk Ledelse" (maj 2015), som er baseret på danske lederes...

Wetland Restoration and Sediment Removal

Data.gov (United States)

Department of the Interior — In 2008, Minnesota’s Private Lands Program and Wetland Management Districts began to compare different methods of restoring prairie pothole wetlands to see if there...

Metabolomics er fremtiden

DEFF Research Database (Denmark)

Pedersern, Birger

2010-01-01

Forskningen i fødevarer har fået et potent redskab i hånden. Metabolomics er vejen frem, mener professor Søren Balling Engelsen fra Københavns Universitet......Forskningen i fødevarer har fået et potent redskab i hånden. Metabolomics er vejen frem, mener professor Søren Balling Engelsen fra Københavns Universitet...

Innovation er brugerdreven!

DEFF Research Database (Denmark)

Helms, Niels Henrik

2008-01-01

Brugerdreven innovation er blevet svaret på mange af de udfordringer, som vores moderne samfund står overfor.Det er skrevet ind i såvel regeringsgrundlaget som i de forskellige tiltag, som skal ruste Danmark i forhold til globaliseringen. Vi har ifølge argumentationen her enrække særlige forudsæt....... Udgivelsesdato: marts 2008...

Emerson Parcel of Dutch Slough Tidal Marsh Restoration Project

Science.gov (United States)

Information about the SFBWQP Emerson Parcel of Dutch Slough Tidal Marsh Restoration Project, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

Jeg Er blevet FRANKofil

DEFF Research Database (Denmark)

Andersson, Lasse

2014-01-01

afhængig af Frank Underwood fra serien House of Cards på den fremadstormende TV-streamingstjenesten Netflix. Jeg har opdaget et nyt internetbaseret datingforhold. Et surrealt, fedt miks af det kyniske og joviale personificeret i karakteren Frank Underwood, som er helt igennem ubehagelig, men fantastisk...... spillet af Kevin Spacey. Og tak til Spacey der for en tid har forladt teateret ’The Old Vic’ i London for at begejstre mig. Der er generelt to årsager til mine FRANKofile tilbøjeligheder. For det første er Netflix’s remake af den tyve år gamle BBC serie House of Cards efter min menig et stykke tv...... anden grund, til at jeg er blevet Frankofil, er, at jeg ikke skal sidde og vente på næste søndag efter søndag efter søndag for at få lov at se næste afsnit. Netflix lagde alle tretten timer af sæson 2 ud på nettet. Jeg afgør selv, hvornår jeg skal have mere Frank! Men på trods af mit narkomanlignende...

Intensive treatment for adults with anorexia nervosa: The cost of weight restoration.

Science.gov (United States)

Guarda, Angela S; Schreyer, Colleen C; Fischer, Laura K; Hansen, Jennifer L; Coughlin, Janelle W; Kaminsky, Michael J; Attia, Evelyn; Redgrave, Graham W

2017-03-01

Weight restoration in anorexia nervosa (AN) is associated with lower relapse risk; however rate of weight gain and percent of patients achieving weight restoration (BMI ≥ 19 at discharge) vary among treatment programs. We compared both cost/pound of weight gained and cost of weight restoration in a hospital-based inpatient (IP)-partial hospitalization (PH) eating disorders program to estimates of these costs for residential treatment. All adult first admissions to the IP-PH program with AN (N = 314) from 2003 to 2015 were included. Cost of care was based on hospital charges, rates of weight gain, and weight restoration data. Results were compared with residential treatment costs extracted from a national insurance claims database and published weight gain data. Average charge/day in the IP-PH program was $2295 for IP and $1567 for PH, yielding an average cost/pound gained of $4089 and $7050, respectively, with 70% of patients achieving weight restoration. Based on published mean weight gain data and conservative cost/day estimates, residential treatment is associated with higher cost/pound, and both higher cost and lower likelihood of weight restoration for most patients. The key metrics used in this study are recommended for comparing the cost-effectiveness of intensive treatment programs for patients with AN. © 2017 Wiley Periodicals, Inc.

South Bay Salt Pond Restoration, Phase II at Ravenswood

Science.gov (United States)

Information about the South Bay Salt Pond Restoration Project: Phase II Construction at Ravenswood, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

Hvornår er man ung?

DEFF Research Database (Denmark)

Gundelach, Peter; Nørregård-Nielsen, Esther C.

2002-01-01

Hvornår er man ung, og hvornår er man voksen? Er der forskelle i befolkningens værdier i forhold til arbejde og politik, når det undersøges ud fra henholdsvis et alders- eller generationsperspektiv? Baseret på data fra den danske del af den internationale værdiundersøgelse vises at der er så store...

Søer 1999

DEFF Research Database (Denmark)

Jensen, J. P.; Søndergaard, M.; Jeppesen, E.

små cladoceer og hjuldyr, og især er maksimumsforekom-sterne af calanoide vandlopper og de små og store cladoceer og daf-nier gået tilbage. Den gennemsnitlige biomasse af dafnier er derimod øget især p.g.a. stigning i de 25 % af søerne med størst forekomster. Dyreplanktons græsning Betragtet under et...

Environmental Restoration Site-Specific Plan for the Paducah Gaseous Diffusion Plant, FY 93

International Nuclear Information System (INIS)

1993-01-01

This report provides an overview of the major Environmental Restoration (ER) concerns at Paducah Gaseous Diffusion Plant (PGDP). The identified solid waste management units at PGDP are listed. In the Department of Energy (DOE) Five Year Plan development process, one or more waste management units are addressed in a series of activity data sheets (ADSs) which identify planned scope, schedule, and cost objectives that are representative of the current state of planned technical development for individual or multiple sites

Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with anti-HER2 therapy

Science.gov (United States)

Giuliano, Mario; Hu, Huizhong; Wang, Yen-Chao; Fu, Xiaoyong; Nardone, Agostina; Herrera, Sabrina; Mao, Sufeng; Contreras, Alejandro; Gutierrez, Carolina; Wang, Tao; Hilsenbeck, Susan G.; De Angelis, Carmine; Wang, Nicholas J.; Heiser, Laura M.; Gray, Joe W.; Lopez-Tarruella, Sara; Pavlick, Anne C.; Trivedi, Meghana V.; Chamness, Gary C.; Chang, Jenny C.; Osborne, C. Kent; Rimawi, Mothaffar F.; Schiff, Rachel

2015-01-01

Purpose To investigate the direct effect and therapeutic consequences of epidermal growth factor receptor 2 (HER2)-targeting therapy on expression of estrogen receptor (ER) and Bcl2 in preclinical models and clinical tumor samples. Experimental design Archived xenograft tumors from two preclinical models (UACC812 and MCF7/HER2-18) treated with ER and HER2-targeting therapies, and also HER2+ clinical breast cancer specimens collected in a lapatinib neoadjuvant trial (baseline and week 2 post treatment), were used. Expression levels of ER and Bcl2 were evaluated by immunohistochemistry and western blot. The effects of Bcl2 and ER inhibition, by ABT-737 and fulvestrant respectively, were tested in parental versus lapatinib-resistant UACC812 cells in vitro. Results Expression of ER and Bcl2 was significantly increased in xenograft tumors with acquired resistance to anti-HER2 therapy, compared with untreated tumors, in both preclinical models (UACC812: ER p=0.0014; Bcl2 p<0.001. MCF7/HER2-18: ER p=0.0007; Bcl2 p=0.0306). In the neoadjuvant clinical study, lapatinib treatment for two weeks was associated with parallel upregulation of ER and Bcl2 (Spearman’s coefficient: 0.70; p=0.0002). Importantly, 18% of tumors originally ER-negative (ER−) converted to ER+ upon anti-HER2 therapy. In ER−/HER2+ MCF7/HER2-18 xenografts, ER re-expression was primarily observed in tumors responding to potent combination of anti-HER2 drugs. Estrogen deprivation added to this anti-HER2 regimen significantly delayed tumor progression (p=0.018). In the UACC812 cells, fulvestrant, but not ABT-737, was able to completely inhibit anti-HER2-resistant growth (p<0.0001). Conclusion HER2 inhibition can enhance or restore ER expression with parallel Bcl2 upregulation, representing an ER-dependent survival mechanism potentially leading to anti-HER2 resistance. PMID:26015514

The role of the AR/ER ratio in ER-positive breast cancer patients.

Science.gov (United States)

Rangel, Nelson; Rondon-Lagos, Milena; Annaratone, Laura; Osella-Abate, Simona; Metovic, Jasna; Mano, Maria Piera; Bertero, Luca; Cassoni, Paola; Sapino, Anna; Castellano, Isabella

2018-03-01

The significance of androgen receptor (AR) in breast cancer (BC) management is not fully defined, and it is still ambiguous how the level of AR expression influences oestrogen receptor-positive (ER+) tumours. The aim of the present study was to analyse the prognostic impact of AR/ER ratio, evaluated by immunohistochemistry (IHC), correlating this value with clinical, pathological and molecular characteristics. We retrospectively selected a cohort of 402 ER+BC patients. On each tumour, IHC analyses for AR, ER, PgR, HER2 and Ki67 were performed and AR+ cases were used to calculate the AR/ER value. A cut-off of ≥2 was selected using receiver-operating characteristic (ROC) curve analyses. RNA from 19 cases with AR/ER≥2 was extracted and used for Prosigna-PAM50 assays. Tumours with AR/ER≥2 (6%) showed more frequent metastatic lymph nodes, larger size, higher histological grade and lower PgR levels than cases with AR/ERAR/ER≥2 had worse disease-free interval (DFI) and disease-specific survival (DSS) (hazard ratios (HR) = 4.96 for DFI and HR = 8.69 for DSS, both P  ≤ 0.004). According to the Prosigna-PAM50 assay, 63% (12/19) of these cases resulted in intermediate or high risk of recurrence categories. Additionally, although all samples were positive for ER assessed by IHC, the molecular test assigned 47.4% (9/19) of BCs to intrinsic non-luminal subtypes. In conclusion, the AR/ER ratio ≥2 identifies a subgroup of patients with aggressive biological features and may represent an additional independent marker of worse BC prognosis. Moreover, the Prosigna-PAM50 results indicate that a significant number of cases with AR/ER≥2 could be non-luminal tumours. © 2018 Society for Endocrinology.

GR and ER co-activation alters the expression of differentiation genes and associates with improved ER+ breast cancer outcome

Science.gov (United States)

West, Diana C.; Pan, Deng; Tonsing-Carter, Eva Y.; Hernandez, Kyle M.; Pierce, Charles F.; Styke, Sarah C.; Bowie, Kathleen R.; Garcia, Tzintzuni I.; Kocherginsky, Masha; Conzen, Suzanne D.

2016-01-01

In estrogen receptor (ER)-negative breast cancer (BC), high tumor glucocorticoid receptor (GR) expression has been associated with a relatively poor outcome. In contrast, using a meta-analysis of several genomic datasets, here we find that tumor GR mRNA expression is associated with improved ER+ relapse-free survival (RFS) (independently of progesterone receptor (PR) expression). To understand the mechanism by which GR expression is associated with a better ER+ BC outcome, the global effect of GR-mediated transcriptional activation in ER+ BC cells was studied. Analysis of GR chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) in ER+/GR+ MCF-7 cells revealed that upon co-activation of GR and ER, GR chromatin association became enriched at proximal promoter regions. Furthermore, following ER activation, increased GR chromatin association was observed at ER, FOXO, and AP1 response elements. In addition, ER associated with GR response elements, suggesting that ER and GR interact in a complex. Co-activation of GR and ER resulted in increased expression (relative to ER activation alone) of transcripts that encode proteins promoting cellular differentiation (e.g. KDM4B, VDR) and inhibiting the Wnt-signaling pathway (IGFBP4). Finally, expression of these individual pro-differentiation genes was associated with significantly improved RFS in ER+ BC patients. Together, these data suggest that the co-expression and subsequent activity of tumor cell GR and ER contribute to the less aggressive natural history of early-stage BC by coordinating the altered expression of genes favoring differentiation. Implications The interaction between estrogen and glucocorticoid receptor activity highlights the importance of context-dependent nuclear receptor function in cancer. PMID:27141101

Endoplasmic Reticulum (ER Stress and Endocrine Disorders

Directory of Open Access Journals (Sweden)

Daisuke Ariyasu

2017-02-01

Full Text Available The endoplasmic reticulum (ER is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR, which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI, Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2 are discussed in this article.

Endoplasmic Reticulum (ER) Stress and Endocrine Disorders

Science.gov (United States)

Ariyasu, Daisuke; Yoshida, Hiderou; Hasegawa, Yukihiro

2017-01-01

The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI), Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2) are discussed in this article. PMID:28208663

A systematic approach to evaluate erosion potential at environmental restoration sites

International Nuclear Information System (INIS)

Veenis, S.J.; Mays, D.C.

1998-01-01

The Environmental Restoration (ER) Project at the Los Alamos National Laboratory (LANL) is responsible for investigation and remediation of solid waste management units (SWMUs) under the Resource Conservation and Recovery Act and area of concerns (AOCs) under the direction of the Department of Energy. During the investigation and remediation phases, information may be gathered that indicates that conditions may be present at the site which may effect surface water quality. Depending on the constituent found, its concentration, and erosion/sediment transport potential, it may be necessary to implement temporary or permanent mitigative measures

Hanford Site waste management and environmental restoration integration plan

International Nuclear Information System (INIS)

Merrick, D.L.

1990-01-01

The ''Hanford Site Waste Management and Environmental Restoration Integration Plan'' describes major actions leading to waste disposal and site remediation. The primary purpose of this document is to provide a management tool for use by executives who need to quickly comprehend the waste management and environmental restoration programs. The Waste Management and Environmental Restoration Programs have been divided into missions. Waste Management consists of five missions: double-shell tank (DST) wastes; single-shell tank (SST) wastes (surveillance and interim storage, stabilization, and isolation); encapsulated cesium and strontium; solid wastes; and liquid effluents. Environmental Restoration consists of two missions: past practice units (PPU) (including characterization and assessment of SST wastes) and surplus facilities. For convenience, both aspects of SST wastes are discussed in one place. A general category of supporting activities is also included. 20 refs., 14 figs., 7 tabs

The structure of the 168Er nucleus and the 166Er(t,p) 168 Er reaction in terms of the sdg interacting boson model

Science.gov (United States)

Akiyama, Y.; Heyde, K.; Arima, A.; Yoshinaga, N.

1986-05-01

Extending the interacting boson model by incorporating besides s and d, also the g-boson, we can describe the population of positive parity states of 168Er in the 166Er(t,P) 168Er reaction rather well. In particular, the excitation of I,Kπi = 4,3 +1; 2,2 +2; 0,0 +3 and 0,0 +4 states is much improved over the sd-IBM approach.

Programs of the Office of Energy Research

International Nuclear Information System (INIS)

1985-07-01

The purpose of this research has been to support the energy technology development programs by providing insight into fundamental science and associated phenomena and developing new or advanced concepts and techniques. Today, this responsibility rests with the Office of Energy Research (ER), DOE, whose present programs have their origins in pioneering energy-related research which was initiated nearly 40 years ago. The Director, Office of Energy Research, also acts as the chief scientist and scientific advisor to the Secretary of Energy for the entire spectrum of energy research and development (R and D) programs of the Department. ER programs include several thousand individual projects and hundreds of laboratories, universities, and other research facilities throughout the United States. The current organization of ER is shown. The budgets for the various ER programs for the last two fiscal years are shown. In the following pages, each of these programs and activities are described briefly for the information of the scientific community and the public at large

In vitro evaluation of marginal microleakage in class V restorations with composite resin in bovine teeth. Laser irradiation influences and the adhesive system in the dentin pre-treatment

International Nuclear Information System (INIS)

Carvalho, Wendell Lima de

2003-01-01

Microleakage is one of the most important reasons to restorations failure, it is the responsible for marginal colors changing, new caries, hipersensibility and pulpar diseases. Several techniques and materials have been studied to eliminate or, at least, to decrease microleakage. The cavities preparation with Er:YAG laser and autoconditioning adhesive are some of these techniques and materials. This research has the objective to compare, in vitro, microleakage in class V cavities, prepared with high rotation (conventional treatment), Er:YAG laser (Enamel-400 mj/2 Hz/128,38 J/Cm 2 , Dentin 250 mJ/ 2 Hz/ 80,24 J/Cm 2 ) and the treatment made at dentin with autoconditioning adhesive (Clerafil SE Bond) using Er:YAG laser (with water or not water) or not using Er:YAG laser. It was used 48 bovines teeth with cavities prepared in vestibular face and gingival wall on cement enamel junction and oclusal wall on enamel. The materials used were autoconditioning adhesive (Clerafil SE Bond) and composite resin Z250. Teeth were divided into four groups of twelve samples each one, according to dentin treatment. Group 1 - Conventional cavity and autoconditioning adhesive. Group 2- Cavity prepared with Er: YAG laser and autoconditioning adhesive. Group 3 - Cavity prepared with Er:YAG laser and dentin conditioning with Er:YAG laser associated to water and autoconditioning adhesive. Group 4 - Cavity prepared with Er:YAG laser and dentin conditioning with Er: YAG laser without water and associated to autoconditioning adhesive. Teeth were restored and stocked at 37 deg C, thermocycled and placed into a 50% silver nitrate solution. Right after, teeth were sliced and evaluated on a stereo microscopic magnifying glass in order to see microleakage degree trying to follow a score from 0 to 3. The findings were submitted to Fisher, Anderson-Darling tests and to the not parametric Sen and Puri test. The results indicated that in gingival edge, the Group 2 showed less microleakage than others

Social Science Methods Used in the RESTORE Project

Science.gov (United States)

Lynne M. Westphal; Cristy Watkins; Paul H. Gobster; Liam Heneghan; Kristen Ross; Laurel Ross; Madeleine Tudor; Alaka Wali; David H. Wise; Joanne Vining; Moira. Zellner

2014-01-01

The RESTORE (Rethinking Ecological and Social Theories of Restoration Ecology) project is an interdisciplinary, multi-institutional research endeavor funded by the National Science Foundation's Dynamics of Coupled Natural Human Systems program. The goal of the project is to understand the links between organizational type, decision making processes, and...

Mississippi Coastal Improvements Program; Evaluation of Barrier Island Restoration Efforts

Science.gov (United States)

2013-09-01

451   ERDC TR-13-12 xx Figure G-14. Alternative #1 Restored conditions for Storm #2; Template C; Without borrow pits. ......... 451   Figure G-15...0.02831685 cubic meters cubic yards 0.7645549 cubic meters degrees Fahrenheit (F-32)/1.8 degrees Celsius feet 0.3048 meters inches 0.0254 meters...conditions for Storm #2; Template A; Without borrow pits. ERDC TR-13-12 451 Figure G-13. Alternative #1 Restored conditions for Storm #2; Template B

De 9 P’er

DEFF Research Database (Denmark)

Rennison, Betina Wolfgang

2017-01-01

Ledere skal i dag selv skabe deres eget rum til ledelse, men hvad er med til at sætte det, hvilke betingelser og udfordringer er der, og hvordan kan lederne skabe sig selv i et hav af forventninger? Dette katalog inviterer til refleksion herom....

Effect of Er3+ Concentration on Upconversion in Hexagonal-Phase NaYF4:Er3+ Nanocrystals

International Nuclear Information System (INIS)

Luo, X J; Yuminami, R; Sakurai, T; Akimoto, K

2013-01-01

A facile synthesis method was developed to produce hexagonal-phase of NaYF 4 nanocrystals (NCs) doped with Er 3+ in different concentration, which showed upconversion (UC) emission from infrared to visible spectral region. This proposed method is simple and less toxic compared with generally used method so far. It was found that up-conversion emission spectra of NaYF 4 :Er 3+ NCs, excited at 1550 nm, included four peaks at about 980 nm, 800 nm, 660 nm and 540 nm. The effect of Er 3+ concentration on UC in β-phase NaYF 4 :Er 3+ NCs were discussed based on the excitation power dependence. The optimum Er 3+ concentration for 2-step and 3-step UC was found to be around 10∼30%.

Hvor anvendelig er PKI?

OpenAIRE

Nielsen, Jon Magne

2006-01-01

Denne oppgaven ser på bruken av elektronisk ID i statlige etater i Norge i dag. Det ses spesielt på om bruken av tekologien PKI er en god løsning på etatenes behov på dette området. Som utgangspunkt for analysen er det sett spesielt på to statlige etater. Disse etatenes behov og bruk av elektronisk ID generelt og PKI spesielt blir undersøkt. Det er videre gjort rede for hvilke lover, forskrifter og andre førende dokumenter som danner de formelle rammebetingelsene for etaters bruk av PKI. ...

Bulk Restoration for SDN-Based Transport Network

Directory of Open Access Journals (Sweden)

Yang Zhao

2016-01-01

Full Text Available We propose a bulk restoration scheme for software defined networking- (SDN- based transport network. To enhance the network survivability and improve the throughput, we allow disrupted flows to be recovered synchronously in dynamic order. In addition backup paths are scheduled globally by applying the principles of load balance. We model the bulk restoration problem using a mixed integer linear programming (MILP formulation. Then, a heuristic algorithm is devised. The proposed algorithm is verified by simulation and the results are analyzed comparing with sequential restoration schemes.

Holes: a novel method for promoting vegetation restoration (Macao)

Science.gov (United States)

Shao-Lin Peng; Yi-Na Yu; Yu-Ping Hou; Long-Sheng Yu; Bao-Ming. Chen

2009-01-01

Restoration Notes have been a distinguishing feature of Ecological Restoration for more than 25 years. This section is geared toward introducing innovative research, tools, technologies, programs, and ideas, as well as providing short-term research results and updates on ongoing efforts.

Hvad f er meningen?

DEFF Research Database (Denmark)

Rydén, Pernille; Ringberg, Torsten; Wilke, Ricky

En forskningsrapport fra CBS om danske lederes opfattelse af sociale medier i detail- og servicebranchen. Rapporten er udarbejdet i regi af Service Platform.......En forskningsrapport fra CBS om danske lederes opfattelse af sociale medier i detail- og servicebranchen. Rapporten er udarbejdet i regi af Service Platform....

A Policy Analysis Perspective on Ecological Restoration

Directory of Open Access Journals (Sweden)

Susan Baker

2013-06-01

Full Text Available Using a simple stages model of the policy process, we explore the politics of ecological restoration using an array of examples drawn across sector, different size and scale, and from different countries. A policy analysis perspective reveals how, at both the program and project levels, ecological restoration operates within a complex and dynamic interplay between technical decision making, ideologies, and interest politics. Viewed through the stages model, restoration policy involves negotiating nature across stages in the policy making process, including agenda setting, policy formulation, implementation, and evaluation. The stages model is a useful heuristic devise; however, this linear model assumes that policy makers approach the issue rationally. In practice, ecological restoration policy takes place in the context of different distributions of power between the various public and private actors involved at the different stages of restoration policy making. This allows us to reiterate the point that ecological restoration is best seen not only as a technical task but as a social and political project.

Hurricanes Katrina and Rita and the Coastal Louisiana Ecosystem Restoration

National Research Council Canada - National Science Library

Zinn, Jeffrey

2005-01-01

... for a $1.1 billion multiyear program to construct five projects that would help to restore portions of the coastal Louisiana ecosystem by slowing the rate of wetland loss and restoring some wetlands...

Bridges to life: evaluation of an in-prison restorative justice intervention.

Science.gov (United States)

Armour, Marilyn Peterson; Sage, John; Rubin, Allen; Windsor, Liliane C

2005-12-01

Restorative justice initiatives have been identified as primarily, if not exclusively, useful as a "front-end" diversionary option reserved for non violent property crimes and minor assaults. In-prison restorative justice programs are rare and have not been examined for their impact on recidivism. Bridges to Life (BTL) is a voluntary, manualized, ecumenical faith-based restorative justice program offered to incarcerated offenders who are within nine months of their release. A survey of BTL graduates (n=1021) found an appreciatively lower recidivism rate than the general population of released inmates. Quantitative and qualitative analyses suggest that BTL helps break through offenders' denial and self-centeredness, exposing them to the impact of their actions and helping them feel the pain their crimes created. Possible reasons for the positive nature of participants' responses are advanced. The use of in-prison restorative justice programs to facilitate offender re-entry is also discussed.

Investigating the evolution of local structure around Er and Yb in ZnO:Er and ZnO:Er, Yb on annealing using X-ray absorption spectroscopy

Science.gov (United States)

Anjana, R.; Jayaraj, M. K.; Yadav, A. K.; Jha, S. N.; Bhattacharyya, D.

2018-04-01

The local structure around Er and Yb centre in ZnO favouring upconversion luminescence was studied using EXAFS (Extended X-ray absorption fine structure spectroscopy). Due to the ionic radii difference between Zn and Er, Yb ions, the dopants cannot replace Zn in the ZnO lattice properly. Er2O3 and Yb2O3 impurity phases are formed at the grain boundaries of ZnO. It is found that the local structure around the Er centre in ZnO is modified on annealing in air. The symmetry around both erbium and ytterbium reduces with increase in annealing temperature. Symmetry reduction will favour the intra-4f transition and the energy transitions causing upconversion luminescence. By fitting the EXAFS data with theoretically simulated data, it is found that the Er centre forms a local structure similar to C4ν symmetry which is a distorted octahedron. On annealing the sample to 1200 °C, all the erbium centres are transformed to C4ν symmetry causing enhanced upconversion emission. Yb centre has also been modified on annealing. The decrease in co-ordination number with annealing temperature will decrease the symmetry and increase the near infrared absorption cross section. The decrease in symmetry around both the erbium and ytterbium centre and formation of C4ν symmetry around Er centre is the reason behind the activation of upconversion luminescence with high temperature annealing in both Er doped and Er, Yb co-doped ZnO samples. The study will be useful for the synthesis of high efficiency upconversion materials.

ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB

International Nuclear Information System (INIS)

Mera, Kentaro; Kawahara, Ko-ichi; Tada, Ko-ichi; Kawai, Kazuhiro; Hashiguchi, Teruto; Maruyama, Ikuro; Kanekura, Takuro

2010-01-01

Proteins are folded properly in the endoplasmic reticulum (ER). Various stress such as hypoxia, ischemia and starvation interfere with the ER function, causing ER stress, which is defined by the accumulation of unfolded protein (UP) in the ER. ER stress is prevented by the UP response (UPR) and ER-associated degradation (ERAD). These signaling pathways are activated by three major ER molecules, ATF6, IRE-1 and PERK. Using HaCaT cells, we investigated ER signaling in human keratinocytes irradiated by environmental doses of ultraviolet B (UVB). The expression of Ero1-Lα, an upstream signaling molecule of ER stress, decreased at 1-4 h after 10 mJ/cm 2 irradiation, indicating that the environmental dose of UVB-induced ER stress in HaCaT cells, without growth retardation. Furthermore, expression of intact ATF6 was decreased and it was translocated to the nuclei. The expression of XBP-1, a downstream molecule of IRE-1, which is an ER chaperone whose expression is regulated by XBP-1, and UP ubiquitination were induced by 10 mJ/cm 2 UVB at 4 h. PERK, which regulates apoptosis, was not phosphorylated. Our results demonstrate that UVB irradiation generates UP in HaCaT cells and that the UPR and ERAD systems are activated to protect cells from UVB-induced ER stress. This is the first report to show ER signaling in UVB-irradiated keratinocytes.

Natural resource damage assessments: Linking injury to restoration

International Nuclear Information System (INIS)

Newell, M.; Collinson-Kahl, C.

1993-01-01

Under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the Oil Pollution Act of 1990 (OPA 90), natural resource trustees have the authority to act on behalf of the public to file claims for damages against potentially responsible parties for injury to, destruction of, or loss of natural resources and related human services caused by releases of hazardous substances or discharges of oil. Damages recovered must be used to restore, replace, or acquire the equivalent of such resources. Therefore, to adequately restore an injured resource and the services it provides, a natural resource restoration proposal should address, as directly as possible, the injuries caused by a hazardous substance release. In other words, the resources restored and services generated by the restoration activities should be commensurate in type and amount with the reduction in services caused by the release. More specifically, the natural resource damage assessment regulations indicate that services should be used as the common currency for linking injury to restoration. The following conceptual steps may be followed to develop a primary restoration program that is linked to the injuries: Define the resources that were injured, and identify the services provided by those resources that were reduced by the injury. Define the baseline levels of the quantity of the resource, and the quantity of the services that would have been provided by the resource if the injury had not occurred. Quantify the interim lost value, which represents the reduction in services (compared to a baseline) from the time of the injury through the time of full recovery of the resources, assuming natural recovery. Evaluate the potential restoration projects for inclusion in the primary restoration program, which is designed to accelerate and enhance natural recovery of the resources and the flow of services from the resources

ER Stress: A Therapeutic Target in Rheumatoid Arthritis?

Science.gov (United States)

Rahmati, Marveh; Moosavi, Mohammad Amin; McDermott, Michael F

2018-04-22

Diverse physiological and pathological conditions that impact on protein folding of the endoplasmic reticulum (ER) cause ER stress. The unfolded protein response (UPR) and the ER-associated degradation (ERAD) pathway are activated to cope with ER stress. In rheumatoid arthritis (RA), inflammation and ER stress work in parallel by driving inflammatory cells to release cytokines that induce chronic ER stress pathways. This chronic ER stress may contribute to the pathogenesis of RA through synoviocyte proliferation and proinflammatory cytokine production. Therefore, ER stress pathways and their constituent elements are attractive targets for RA drug development. In this review, we integrate current knowledge of the contribution of ER stress to the overall pathogenesis of RA, and suggest some therapeutic implications of these discoveries. Copyright © 2018 Elsevier Ltd. All rights reserved.

Environmental Sciences Division Groundwater Program Office

International Nuclear Information System (INIS)

1993-01-01

This first edition of the Martin Marietta Energy Systems, Inc., (Energy Systems) Groundwater Program Annual Report summarizes the work carried out by the Energy Systems GWPO for fiscal year (FY) 1993. This introductory section describes the GWPO's staffing, organization, and funding sources. The GWPO is responsible for coordination and oversight for all components of the groundwater program at the three Oak Ridge facilities [ORNL, the Oak Ridge Y-12 Plant, and the Oak Ridge K-25 Site], and the PGDP and PORTS, respectively. Several years ago, Energy systems senior management recognized that the manner in which groundwater activities were conducted at the five facilities could result in unnecessary duplication of effort, inadequate technical input to decisions related to groundwater issues, and could create a perception within the regulatory agencies of a confusing and inconsistent approach to groundwater issues at the different facilities. Extensive interactions among management from Environmental Compliance, Environmental Restoration (ER), Environmental Sciences Division, Environmental Safety and Health, and the five facilities ultimately led to development of a net technical umbrella organization for groundwater. On April 25, 1991, the GWPO was authorized to be set up within ORNL thereby establishing a central coordinating office that would develop a consistent technical and administrative direction for the groundwater programs of all facilities and result in compliance with all relevant U.S. Environmental Protection Agency (EPA) regulations such as RCRA and Comprehensive Environmental Restoration, Compensation and Liability Act (CERCLA) as well as U.S. Department of Energy (DOE) regulations and orders. For example, DOE Order 5400.1, issued on November 9, 1988, called for each DOE facility to develop an environmental monitoring program for all media (e.g., air, surface water, and groundwater)

Tensile bond strength and SEM analysis of enamel etched with Er:YAG laser and phosphoric acid: a comparative study in vitro

International Nuclear Information System (INIS)

Sasaki, Luis H.; Tanaka, Celso Shin-Ite; Lobo, Paulo D.C.; Villaverde, Antonio B.; Moriyama, Eduardo H.; Brugnera Junior, Aldo; Moriyama, Yumi; Watanabe, Ii-Sei

2008-01-01

Er:YAG laser has been studied as a potential tool for restorative dentistry due to its ability to selectively remove oral hard tissue with minimal or no thermal damage to the surrounding tissues. The purpose of this study was to evaluate in vitro the tensile bond strength (TBS) of an adhesive/composite resin system to human enamel surfaces treated with 37% phosphoric acid, Er:YAG laser (λ=2.94 μm) with a total energy of 16 J (80 mJ/pulse, 2Hz, 200 pulses, 250 ms pulse width), and Er:YAG laser followed by phosphoric acid etching. Analysis of the treated surfaces was performed by scanning electron microscopy (SEM) to assess morphological differences among the groups. TBS means (in MPa) were as follows: Er:YAG laser + acid (11.7 MPa) > acid (8.2 MPa) > Er:YAG laser (6.1 MPa), with the group treated with laser+acid being significantly from the other groups (p=0.0006 and p= 0.00019, respectively). The groups treated with acid alone and laser alone were significantly different from each other (p=0.0003). The SEM analysis revealed morphological changes that corroborate the TBS results, suggesting that the differences in TBS means among the groups are related to the different etching patterns produced by each type of surface treatment. The findings of this study indicate that the association between Er:YAG laser and phosphoric acid can be used as a valuable resource to increase bond strength to laser-prepared enamel. (author)

Fremtidens undervisningsmiljøer

DEFF Research Database (Denmark)

2013-01-01

Som oplægget til dette temanummer af LOM også indikerede, så sætter vi fokus på fremtidens undervisningsmiljøer på universiteter og UCer. Fremtidens undervisningsmiljøer har mange facetter, hvilket samlingen af artikler også illustrerer. “Fremtidens Undervisningsmiljø” handler om eksisterende erf...

Suppression of concentration quenching of Er-related luminescence in Er-doped GaN

International Nuclear Information System (INIS)

Chen Shaoqiang; Tomita, Shigeo; Kudo, Hiroshi; Akimoto, Katsuhiro; Dierre, Benjamin; Lee, Woong; Sekiguchi, Takashi

2010-01-01

Erbium-doped GaN with different doping concentrations were grown by ammonia-source molecular beam epitaxy. The intra-4f-shell transitions related green luminescence were observed by both photoluminescence (PL) and cathodoluminescence (CL) measurements. It was found that concentration quenching of Er-related luminescence was observed in PL measurements while not in CL measurements. The different excitation and relaxation processes are suggested as the cause of the concentration quenching characteristics between PL and CL. The strong Er-related CL intensity in highly doped GaN demonstrates that high energy excitation is a promising approach to suppress the concentration quenching in Er-doped GaN.

Desirable forest structures for a restored Front Range

Science.gov (United States)

Yvette L. Dickinson; Rob Addington; Greg Aplet; Mike Babler; Mike Battaglia; Peter Brown; Tony Cheng; Casey Cooley; Dick Edwards; Jonas Feinstein; Paula Fornwalt; Hal Gibbs; Megan Matonis; Kristen Pelz; Claudia Regan

2014-01-01

As part of the federal Collaborative Forest Landscape Restoration Program administered by the US Forest Service, the Colorado Front Range Collaborative Forest Landscape Restoration Project (FR-CFLRP, a collaborative effort of the Front Range Roundtable1 and the US Forest Service) is required to define desired conditions for lower montane ponderosa pine (Pinus ponderosa...

7 CFR 1730.28 - Emergency Restoration Plan (ERP).

Science.gov (United States)

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Emergency Restoration Plan (ERP). 1730.28 Section... § 1730.28 Emergency Restoration Plan (ERP). (a) Each borrower with an approved RUS electric program loan as of October 12, 2004 shall have a written ERP no later than January 12, 2006. The ERP should be...

South Bay Salt Pond Tidal Wetland Restoration Phase II Planning

Science.gov (United States)

Information about the SFBWQP South Bay Salt Pond Tidal Wetland Restoration Phase II Planning project, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic re

Er moral bare noget vi leger?

DEFF Research Database (Denmark)

Thomsen, Frej Klem

2014-01-01

Hvis man er skeptiker, så er moral nemlig altid kun et udtryk for psykologi og kultur, også når det handler om for eksempel misbrug af børn i Tønder-sagen eller terror-angreb i Madrid, London og Mumbai .......Hvis man er skeptiker, så er moral nemlig altid kun et udtryk for psykologi og kultur, også når det handler om for eksempel misbrug af børn i Tønder-sagen eller terror-angreb i Madrid, London og Mumbai ....

Completion Report for Well ER-EC-8

International Nuclear Information System (INIS)

2004-01-01

Well ER-EC-8 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 129.8 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 609.6 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 98.4 meters, 24 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on evaluation of composite drill cuttings collected every 3 meters, and 20 sidewall samples taken at various depths below 157.9 meters, supplemented by geophysical log data and results of detailed chemical and mineralogical studies of rock samples. Drilling began in Tertiary-age tuff of the Thirsty Canyon Group, and penetrated tuffs of the Beatty Wash Formation, tuff of Buttonhook Wash, and the upper portion of the Ammonia Tanks Tuff. The geologic interpretation of data from this well helps define the location of the western margin of the Timber Mountain caldera complex in the southwestern Nevada volcanic field. Geologic and hydrologic data from the well will aid in development of models to predict groundwater flow and contaminant migration within and near the Nevada Test Site

The Paradox of Restoring Native River Landscapes and Restoring Native Ecosystems in the Colorado River System

Science.gov (United States)

Schmidt, J. C.

2014-12-01

Throughout the Colorado River basin (CRb), scientists and river managers collaborate to improve native ecosystems. Native ecosystems have deteriorated due to construction of dams and diversions that alter natural flow, sediment supply, and temperature regimes, trans-basin diversions that extract large amounts of water from some segments of the channel network, and invasion of non-native animals and plants. These scientist/manager collaborations occur in large, multi-stakeholder, adaptive management programs that include the Lower Colorado River Multi-Species Conservation Program, the Glen Canyon Dam Adaptive Management Program, and the Upper Colorado River Endangered Species Recovery Program. Although a fundamental premise of native species recovery is that restoration of predam flow regimes inevitably leads to native species recovery, such is not the case in many parts of the CRb. For example, populations of the endangered humpback chub (Gila cypha) are largest in the sediment deficit, thermally altered conditions of the Colorado River downstream from Glen Canyon Dam, but these species occur in much smaller numbers in the upper CRb even though the flow regime, sediment supply, and sediment mass balance are less perturbed. Similar contrasts in the physical and biological response of restoration of predam flow regimes occurs in floodplains dominated by nonnative tamarisk (Tamarix spp.) where reestablishment of floods has the potential to exacerbate vertical accretion processes that disconnect the floodplain from the modern flow regime. A significant challenge in restoring segments of the CRb is to describe this paradox of physical and biological response to reestablishment of pre-dam flow regimes, and to clearly identify objectives of environmentally oriented river management. In many cases, understanding the nature of the perturbation to sediment mass balance caused by dams and diversions and understanding the constraints imposed by societal commitments to provide

Environmental Restoration Contractor Waste Minimization and Pollution Prevention Plan

International Nuclear Information System (INIS)

Duvon, D. K.

1998-01-01

This plan contains the Pollution Prevention (P2) Program for the Environmental Restoration Contractor (ERC). The plan outlines the activities and schedules developed by the Bechtel Hanford, Inc.(BHI) to reduce the quantity and toxicity of waste dispositioned as a result of restoration and remediation activities. The purpose of this plan is to guide ERC projects in meeting and documenting compliance with requirements for pollution prevention. This plan contains the objectives, strategy, and support activities of the ERC P2 Program

Self-diffusion of Er and Hf inpure and HfO2-doped polycrystalline Er2O3

International Nuclear Information System (INIS)

Scheidecker, R.W.

1979-01-01

Using a tracer technique, self-diffusion of Er and Hf was measured over the approximate temperature interval of 1600 to 1970 0 C in pure and HfO 2 -doped polycryatalline Er 2 O 3 . Up to about 10 m/o HfO 2 dopant level, the Er self-diffusion coefficients followed a relationship based on cation vacancies. Above 10 m/o HfO 2 , deviation from this relationship occurred, apparently due to clustering of cation vacancies and oxygen interstitials around the dopant hafnia ion. The activation energy for the self-diffusion of Er in pure Er 2 O 3 was 82.2 Kcal/mole and increased with the HfO 2 dopant level present. Self-diffusion of Hf was measured in pure Er 2 O 3 having two impurity levels, and a separation of the grain boundary. The volume diffusion of Hf showed both extrinsic and intrinsic behavior with the transition temperature increasing with the impurity level present in Er 2 O 3 . The activation energy for Hf volume diffusion in the intrinsic region was high, i.e. 235 -+ 9.5 Kcal/mole. The grain boundary diffusion was apparently extrinsic over the entire temperature interval Very low Hf self diffusion rates were found in both pure and HfO 2 doped Er 2 O 3 compositions. Despite a clustering effect, the HfO 2 dopant increased the Hf volume diffusion coefficients

Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival.

Directory of Open Access Journals (Sweden)

Tomohisa Mori

Full Text Available The membrane of the endoplasmic reticulum (ER of a cell forms contacts directly with mitochondria whereby the contact is referred to as the mitochondrion-associated ER membrane or the MAM. Here we found that the MAM regulates cellular survival via an MAM-residing ER chaperone the sigma-1 receptor (Sig-1R in that the Sig-1R chaperones the ER stress sensor IRE1 to facilitate inter-organelle signaling for survival. IRE1 is found in this study to be enriched at the MAM in CHO cells. We found that IRE1 is stabilized at the MAM by Sig-1Rs when cells are under ER stress. Sig-1Rs stabilize IRE1 and thus allow for conformationally correct IRE1 to dimerize into the long-lasting, activated endonuclease. The IRE1 at the MAM also responds to reactive oxygen species derived from mitochondria. Therefore, the ER-mitochondrion interface serves as an important subcellular entity in the regulation of cellular survival by enhancing the stress-responding signaling between mitochondria, ER, and nucleus.

Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival.

Science.gov (United States)

Mori, Tomohisa; Hayashi, Teruo; Hayashi, Eri; Su, Tsung-Ping

2013-01-01

The membrane of the endoplasmic reticulum (ER) of a cell forms contacts directly with mitochondria whereby the contact is referred to as the mitochondrion-associated ER membrane or the MAM. Here we found that the MAM regulates cellular survival via an MAM-residing ER chaperone the sigma-1 receptor (Sig-1R) in that the Sig-1R chaperones the ER stress sensor IRE1 to facilitate inter-organelle signaling for survival. IRE1 is found in this study to be enriched at the MAM in CHO cells. We found that IRE1 is stabilized at the MAM by Sig-1Rs when cells are under ER stress. Sig-1Rs stabilize IRE1 and thus allow for conformationally correct IRE1 to dimerize into the long-lasting, activated endonuclease. The IRE1 at the MAM also responds to reactive oxygen species derived from mitochondria. Therefore, the ER-mitochondrion interface serves as an important subcellular entity in the regulation of cellular survival by enhancing the stress-responding signaling between mitochondria, ER, and nucleus.

Er jeres ledere 'likeable'?

DEFF Research Database (Denmark)

Nielsen, Rikke Kristine

2013-01-01

Færdigheder: Oftest er lederne langtfra de første til at kaste sig over ny teknologi. It-kundskaberne på chefgangen trænger til en opgradering.......Færdigheder: Oftest er lederne langtfra de første til at kaste sig over ny teknologi. It-kundskaberne på chefgangen trænger til en opgradering....

Development of an Integrated Performance Evaluation Program (IPEP) for the Department of Energy's Office of Environmental Restoration and Waste Management

International Nuclear Information System (INIS)

Streets, W.E.; Ka; Lindahl, P.C.; Bottrell, D.; Newberry, R.; Morton, S.; Karp, K.

1993-01-01

Argonne National Laboratory (ANL), in collaboration with DOE's Radiological and Environmental Sciences Laboratory (RESL), Environmental Measurements Laboratory (EML), and Grand Junction Project Office (GJPO), is working with the Department of Energy (DOE) Headquarters and the US Environmental Protection Agency (EPA) to develop the Integrated Performance Evaluation Program (IPEP). The purpose of IPEP is to integrate performance evaluation (PE) information from existing PE programs with expanded quality assurance (QA) activities to develop information about the quality of radiological, mixed waste, and hazardous environmental sample analyses provided by all laboratories supporting DOE Environmental Restoration and Waste Management (EM) programs. The IPEP plans to utilize existing PE programs when available and appropriate for use by DOE-EM; new PE programs will be developed only when no existing program meets DOE's needs

Information Management Architecture for an Integrated Computing Environment for the Environmental Restoration Program. Volume 1, Introduction

International Nuclear Information System (INIS)

1994-09-01

As part of the Environmental Restoration Program at Martin Marietta, IEM (Information Engineering Methodology) was developed as part of a complete and integrated approach to the progressive development and subsequent maintenance of automated data sharing systems. This approach is centered around the organization's objectives, inherent data relationships and business practices. IEM provides the Information Systems community with a tool kit of disciplined techniques supported by automated tools. It includes seven stages: Information Strategy Planning; Business Area Analysis; Business System Design; Technical Design; Construction; Transition; Production

Synthesis of Er and Er : Yb doped sol–gel derived silica glass and ...

Indian Academy of Sciences (India)

Unknown

Materials Science Centre, †Central Research Facility, Optical Fibre Unit, Indian Institute of Technology,. Kharagpur 721 302, India. MS received 1 March 2004; revised 4 July 2004. Abstract. Er3+ and Er3+ : Yb3+ doped optical quality, crack and bubble free glasses for possible use in mak- ing laser material have been ...

Process benchmarking for improvement of environmental restoration activities

International Nuclear Information System (INIS)

Celorie, J.A.; Selman, J.R.; Larson, N.B.

1995-01-01

A process benchmarking study was initiated by the Office of Environmental Management (EM) of the US Department of Energy (DOE) to analyze and improve the department's environmental assessment and environmental restoration (ER) processes. The purpose of this study was to identify specific differences in the processes and implementation procedures used at comparable remediation sites to determine best practices which had the greatest potential to minimize the cost and time required to conduct remedial investigation/ feasibility study (RI/FS) activities. Technical criteria were identified and used to select four DOE, two Department of Defense (DOD), and two Environmental Protection Agency (EPA) restoration sites that exhibited comparable characteristics and regulatory environments. By comparing the process elements and activities executed at the different sites for similar endpoints, best practices were identified for streamlining process elements and minimizing non-value-added activities. Critical measures that influenced process performance were identified and characterized for the sites. This benchmarking study focused on two processes and the internal/external review of documents and the development of the initial evaluation and data collection plan (IEDCP)--since these had a great potential for savings, a high impact on other processes, and a high probability for implementation

Multi-method characterization of low-level radioactive waste at two Sandia National Laboratories environmental restoration sites

International Nuclear Information System (INIS)

Johnson, C.E. Jr.; Galloway, R.B.; Dotson, P.W.

1999-01-01

This paper discusses the application of multiple characterization methods to radioactive wastes generated by the Sandia National Laboratories/New Mexico (SNL/NM) Environmental Restoration (ER) Project during the excavation of buried materials at the Classified Waste Landfill (CWLF) and the Radioactive Waste Landfill (RWL). These waste streams include nuclear weapon components and other refuse that are surface contaminated or contain sealed radioactive sources with unknown radioactivity content. Characterization of radioactive constituents in RWL and CWLF waste has been problematic, due primarily to the lack of documented characterization data prior to burial. A second difficulty derives from the limited information that ER project personnel have about weapons component design and testing that was conducted in the early days of the Cold War. To reduce the uncertainties and achieve the best possible waste characterization, the ER Project has applied both project-specific and industry-standard characterization methods that, in combination, serve to define the types and quantities of radionuclide constituents in the waste. The resulting characterization data have been used to develop waste profiles for meeting disposal site waste acceptance criteria

Science driven restoration: A candle in a demon haunted world—response to cabin

Science.gov (United States)

Christian P. Giardina; Creighton M. Litton; Jarrod M. Thaxton; Susan Cordell; Lisa J. Hadway; Darren R. Sandquist

2007-01-01

Cabin (2007) asks whether formal science is an effective framework and methodology for designing and implementing ecological restoration programs. He argues that beyond certain ancillary benefits, restoration science has little of practical value to offer the practice of restoration. He goes on to suggest that restoration science most often represents an impediment to...

Vidensledelse er også en social praksis

DEFF Research Database (Denmark)

Lauring, Jakob; Waldstrøm, Christian

2006-01-01

lys er det utroligt vigtigt at personalefunktionen i virksomheden er klar over de processer der udspiller sig, og aktivt tager fat om problemerne der ligger i disse barrierer. Vores egne undersøgelser viser, at på trods af opstillingen af teknologiske systemer til vidensdeling, er der stadig...... væsentlige ledelsesmæssige opgaver i forhold til sociale aspekter ved arbejdet i en organisation, som skal varetages hvis vidensdelingen skal fremmes succesfuldt. Det er væsentligt at forstå, at vidensledelse ikke blot handler om cirkulering af information, men også er forbundet mere generelt til ledelse som...

Technical Approach and Plan for Transitioning Spent Nuclear Fuel (SNF) Project Facilities to the Environmental Restoration Program

International Nuclear Information System (INIS)

SKELLY, W.A.

1999-01-01

This document describes the approach and process in which the 100-K Area Facilities are to be deactivated and transitioned over to the Environmental Restoration Program after spent nuclear fuel has been removed from the K Basins. It describes the Transition Project's scope and objectives, work breakdown structure, activity planning, estimated cost, and schedule. This report will be utilized as a planning document for project management and control and to communicate details of project content and integration

Bond strength of an adhesive system irradiated with Nd:YAG laser in dentin treated with Er:YAG laser

International Nuclear Information System (INIS)

Malta, D A M P; De Andrade, M F; Costa, M M; Lizarelli, R F Z; Pelino, J E P

2008-01-01

The purpose of this in vitro study was to verify through micro tensile bond test the bond strength of an adhesive system irradiated with Nd:YAG laser in dentine previously treated with Er:YAG laser. Twenty caries free extracted human third molars were used. The teeth were divided in four experimental groups (n = 5): (G1) control group; (G2) irradiation of the adhesive system with the Nd:YAG laser; (G3) dentin treatment with Er:YAG laser; (G4) dentin treatment with Er:YAG laser followed by the irradiation of the adhesive system with Nd:YAG laser. The Er:YAG laser fluency parameter for the dentin treatment was of 60 J/cm 2 . The adhesive system was irradiated with the Nd:YAG laser with fluency of 100 J/cm 2 . Dental restorations were performed with Adper Single Bond 2/Z250. One tooth from each group was prepared for the evaluation of the adhesive interface under SEM and bond failure tests were also performed and evaluated. The statistical analysis showed statistical significant difference between the groups G1 and G3, G1 and G4, G2 and G3, and G2 and G4; and similarity between the groups G1 and G2, and G3 and G4. The adhesive failures were predominant in all the experimental groups. The SEM analysis showed an adhesive interface with features confirming the results of the mechanical tests. The Nd:YAG laser on the adhesive system did not influence the bond strength in dentin treated or not with the Er:YAG laser

Forenklingens fire F'er

DEFF Research Database (Denmark)

Bentzen, Tina Øllgaard

2017-01-01

At fjerne styring er det, man ofte forbinder med afbureaukratisering, men det er ikke tilstrækkeligt, når man vil gå fra flotte ambitioner til en styring, som reelt opleves enklere. For at forenkle må man også forandre, forankre og fastholde styring, og det må ske i et samspil mellem de aktører, ...

Effects of functional restoration versus 3 hours per week physical therapy: a randomized controlled study.

Science.gov (United States)

Jousset, Nathalie; Fanello, Serge; Bontoux, Luc; Dubus, Valérie; Billabert, Colette; Vielle, Bruno; Roquelaure, Yves; Penneau-Fontbonne, Dominique; Richard, Isabelle

2004-03-01

Randomized parallel-group comparative trial with a 6-month follow-up period. To compare, in chronic low back pain patients, the effectiveness of a functional restoration program, including intensive physical training, occupational therapy, and psychological support to an active individual therapy consisting of 3 hours physical therapy per week during 5 weeks. Controlled studies conducted in the United States showed a benefit of functional restoration in patients with low back pain, especially on return to work. Randomized Canadian and European trials had less favorable results. In France, there has been up to now no randomized study. Controlled studies suggested a positive effect of functional restoration programs. Eighty-six patients with low back pain were randomized to either the functional restoration (44 patients) or the active individual therapy (42 patients) program. One person in each group never started the program. Two patients did not complete the functional restoration program, and one was lost to follow-up at 6 months. The mean number of sick-leave days in the 2 previous years was 6 months. After adjustment on the variable "workplace enrolled in an ergonomic program", the mean number of sick-leave days was significantly lower in the functional restoration group. Physical criteria and treatment appreciation were also better. There was no significant difference in the intensity of pain, the quality of life and functional indexes, the psychological characteristics, the number of contacts with the medical system, and the drug intake. This study demonstrates the effectiveness of a functional restoration program on important outcome measures, such as sick leave, in a country that has a social system that protects people facing difficulties at work.

Restorative Justice in Everyday Life: Beyond the Formal Ritual

Science.gov (United States)

Wachtel, Ted

2003-01-01

Restorative justice provides a promising alternative to punitive models in justice and education. Most programs to date have focused on "conferencing," where victims and offenders are brought together for mediation and reconciliation. This article extends the restorative model to the entire milieu of an alternative school setting. (Contains 3…

Ecosystem Management and Restoration. Overview of Stream Restoration Technology: State of the Science. EMRRP, Volume 2, Number 3

National Research Council Canada - National Science Library

Fischenich, J

1999-01-01

The Ecosystem Management and Restoration Research Program (EMRRP), established in 1997, provides state-of-the-science techniques for prediction and analysis of environmental impacts of Corps projects and activities...

Optimal fodring af goldkøer

DEFF Research Database (Denmark)

Bjerre-Harpøth, Vibeke; Damgaard, Birthe Marie

2013-01-01

Et forsøg har vist, at køer på lavt energiniveau i goldperioden var fysiologisk sundere og havde mindre risiko for at udvikle stofskiftesygdomme end køer på et højt energiniveau. Forsøget viste også, at køer på et normalt energiniveau i senlaktationen gav mere mælk i den efterfølgende laktation e...

Er KU et mobbeuniversitet?

DEFF Research Database (Denmark)

Olden-Jørgensen, Sebastian

2009-01-01

Ansatte på KU mobber hverken mere eller mindre end på andre danske arbejdspladser. Mediernes dækning af APV-undersøgelsens resultater mht. mobning er sensationalistisk og delvis vildledende.......Ansatte på KU mobber hverken mere eller mindre end på andre danske arbejdspladser. Mediernes dækning af APV-undersøgelsens resultater mht. mobning er sensationalistisk og delvis vildledende....

Environmental Restoration and Waste Management (EM) program: An introduction

International Nuclear Information System (INIS)

1990-12-01

This booklet introduces the reader to the mission and functions of a major new unit within the US Department of Energy (DOE): the Office of Environmental Restoration and Waste Management (EM). The Secretary of Energy established EM in November 1989, implementing a central purpose of DOE's first annual Environmental Restoration and Waste Management Five-Year Plan, which had appeared three months earlier. The contents of this booklet, and their arrangement, reflect the annual update of the Five-Year Plan. The Five-Year Plan supports DOE's strategy for meeting its 30-year compliance and cleanup goal. This strategy involves: focusing DOE's activities on eliminating or reducing known or recognized potential risks to worker and public health and the environment, containing or isolating, removing, or detoxifying onsite and offsite contamination, and developing technology to achieve DOE's environmental goals

Spectral-converting behaviors of Er{sup 3+} and Er{sup 3+}–Yb{sup 3+} doped YOCl phosphors

Energy Technology Data Exchange (ETDEWEB)

Park, Sangmoon, E-mail: spark@silla.ac.kr [Center for Green Fusion Technology and Department of Engineering in Energy and Applied Chemistry, Silla University, Busan 617-736 (Korea, Republic of); Cho, So-Hye [Center for Materials Architecturing, Institute of Multidisciplinary Convergence of Materials, Korea Institute of Science and Technology, Seoul 130-650 (Korea, Republic of)

2014-01-25

Highlights: • Luminescent materials of YOCl:Er,Yb were prepared using NH{sub 4}Cl flux. • Interesting spectral-converting behaviors were observed in the phosphors. • 980 or 1550 nm diode laser was irradiated for up-converting study. • A multi-photon process in the phosphors was calculated. -- Abstract: Luminescent materials composed of Y{sub 1−m−n}Er{sub m}Yb{sub n}OCl (m = 0.001–0.1, n = 0.005–0.1) were prepared via a solid-state reaction using NH{sub 4}Cl flux. Photoluminescence spectra, the dependence of the luminescent intensity as a function of Er{sup 3+} content, and their CIE coordinates of the Er{sup 3+}-doped layered YOCl compounds were also investigated under near-ultraviolet (NUV) and visible lights. The spectral up-converting properties of Er{sup 3+} and Er{sup 3+}–Yb{sup 3+} in YOCl phosphors were elucidated under 980 and 1550 nm diode laser irradiations. This up-conversion emission spectra and the pump power dependence versus emission intensity observed in the Y{sub 0.9}Er{sub 0.1}OCl up-conversion phosphors gave rise to one- and two-photon processes. The up-conversion mechanism of Er{sup 3+} and Yb{sup 3+} ions in YOCl was described by a schematic energy-level diagram. Through the use of these up-conversion luminescent materials, the desired emitting lights throughout the orange and red regions of the spectra were achieved.

The notion and basic principles of restorative justice

Directory of Open Access Journals (Sweden)

Ćopić Sanja

2007-01-01

Full Text Available One of the most important achievements of the contemporary criminal justice system and criminal policy is development of the concept of restorative justice. Contemporary concept of restorative justice was developed in 1970s on the basis of the criticism of the traditional criminal law and criminal justice system. Since that time, it has been developing through different programs in many countries. Reform of the criminal justice system in Serbia staring from 2002 went into direction of entering elements of restorative justice into existing criminal justice system. In that sense, development of restorative justice is still at the beginning in our country. However, it can be noticed that there is a low level of awareness on the nature and importance of restorative forms of response to crime among our professionals, as well as a lack of understanding of the concept itself. Due to that, the aim of the paper is to enable better understanding of restorative concept in general through defining restorative justice and basic principles it relies on. That may put a basis for further recognition of restorative elements in our criminal justice system, which may provide adequate implementation of relevant provisions of restorative character in practice. .

ER stress-induced protein, VIGG, disturbs plant cation homeostasis, which is correlated with growth retardation and robustness to ER stress

International Nuclear Information System (INIS)

Katoh, Hironori; Fujita, Keiko; Takuhara, Yuki; Ogawa, Atsushi; Suzuki, Shunji

2011-01-01

Highlights: → VIGG is an ER stress-induced protein in plant. → We examine the characteristics of VIGG-overexpressing Arabidopsis plants. → VIGG-overexpressing plants reveal growth retardation and robustness to ER stress. → VIGG disturbs cation homeostasis in plant. -- Abstract: VIGG is a putative endoplasmic reticulum (ER) resident protein induced by virus infection and ER stress, and is correlated with fruit quality in grapevine. The present study was undertaken to determine the biological function of VIGG in grapevine. Experiments using fluorescent protein-VIGG fusion protein demonstrated that VIGG is localized in ER and the ER targeting sequence is in the N-terminus. The overexpression of VIGG in Arabidopsis plant led to growth retardation. The rosette leaves of VIGG-overexpressing plants were smaller than those of the control plants and rolled at 42 days after seeding. VIGG-overexpressing plants revealed robustness to ER stress as well as the low expression of ER stress marker proteins, such as the luminal binding proteins. These characteristics of VIGG-overexpressing plants were supported by a microarray experiment that demonstrated the disruption of genes related to ER stress response and flowering, as well as cation mobility, in the plants. Finally, cation homeostasis in the plants was disturbed by the overexpression of VIGG. Taken together, these results suggest that VIGG may disturb cation homeostasis in plant, which is correlated with the robustness to ER stress and growth retardation.

ER stress-induced protein, VIGG, disturbs plant cation homeostasis, which is correlated with growth retardation and robustness to ER stress

Energy Technology Data Exchange (ETDEWEB)

Katoh, Hironori; Fujita, Keiko; Takuhara, Yuki [Laboratory of Fruit Genetic Engineering, The Institute of Enology and Viticulture, University of Yamanashi, Kofu, Yamanashi 400-0005 (Japan); Ogawa, Atsushi [Department of Biological Production, Akita Prefectural University, Shimosinjyou-nakano 241-438, Akita 010-0195 (Japan); Suzuki, Shunji, E-mail: suzukis@yamanashi.ac.jp [Laboratory of Fruit Genetic Engineering, The Institute of Enology and Viticulture, University of Yamanashi, Kofu, Yamanashi 400-0005 (Japan)

2011-02-18

Highlights: {yields} VIGG is an ER stress-induced protein in plant. {yields} We examine the characteristics of VIGG-overexpressing Arabidopsis plants. {yields} VIGG-overexpressing plants reveal growth retardation and robustness to ER stress. {yields} VIGG disturbs cation homeostasis in plant. -- Abstract: VIGG is a putative endoplasmic reticulum (ER) resident protein induced by virus infection and ER stress, and is correlated with fruit quality in grapevine. The present study was undertaken to determine the biological function of VIGG in grapevine. Experiments using fluorescent protein-VIGG fusion protein demonstrated that VIGG is localized in ER and the ER targeting sequence is in the N-terminus. The overexpression of VIGG in Arabidopsis plant led to growth retardation. The rosette leaves of VIGG-overexpressing plants were smaller than those of the control plants and rolled at 42 days after seeding. VIGG-overexpressing plants revealed robustness to ER stress as well as the low expression of ER stress marker proteins, such as the luminal binding proteins. These characteristics of VIGG-overexpressing plants were supported by a microarray experiment that demonstrated the disruption of genes related to ER stress response and flowering, as well as cation mobility, in the plants. Finally, cation homeostasis in the plants was disturbed by the overexpression of VIGG. Taken together, these results suggest that VIGG may disturb cation homeostasis in plant, which is correlated with the robustness to ER stress and growth retardation.

New strategies to increase the restoration success of post-mining landscapes: the application of cyanobacteria to seed-based rehabilitation programs

Science.gov (United States)

Muñoz-Rojas, Miriam; Raúl Román Fernández, José; Roncero Ramos, Beatriz; Cantón Castilla, Yolanda

2017-04-01

Despite the large efforts and investments to dryland ecosystems restoration worldwide, land rehabilitation in these areas has very low rates of success. Most of the challenges in landscape-scale restoration come from the lack of suitable soil substrates to support plant establishment and to ultimately achieve functional ecosystems. A common practice during extractive operations such as open-cut and strip mining is the removal of the topsoil layer that is subsequently stockpiled and respread in areas targeted for restoration. This topsoil is a crucial source of seeds, nutrients, and microorganisms but is a scarce resource which challenges the success of many restoration programs. In these conditions, the use of direct seeding of key native plant species becomes critical to reinstate biodiverse vegetation communities. Alternative soil substrates such as overburden or waste materials produced in mining operations are increasingly being used as growth media in restoration. However, these soil substrates can have inadequate levels of pH or salinity for plant growth and in most cases are depleted in organic materials and nutrients. In these conditions, the establishment of native plant species can be extremely difficult with a consequent potential loss of biodiversity. Development of appropriate soil structures such as technosols can be extremely expensive and demanding in terms of time and natural resources soils and therefore new approached need to be explored. In the last years, the potential of cyanobacteria biological crust to restore soil functionality in degraded has been highlighted because of their important role in controlling soil structure, preventing soil erosion and N and C fixation. Nevertheless, many research gaps still remain in their application to restore soil functionality in seed-based restoration practices. In this study, we test the potential of cyanobacteria inoculation to restore soil functions of soil materials used in post-mine restoration

Structure of the /sup 168/Er nucleus and the /sup 166/Er(t,p)/sup 168/Er reaction in terms of the sdg interacting boson model

Energy Technology Data Exchange (ETDEWEB)

Akiyama, Y.; Heyde, K.; Arima, A.; Yoshinaga, N.

1986-05-29

Extending the interacting boson model by incorporating besides s and d, also the g-boson, we can describe the population of positive parity states of /sup 168/Er in the /sup 166/Er(t,P)/sup 168/Er reaction rather well. In particular, the excitation of I,Ksub(i)sup(..pi..) = 4,3/sub 1//sup +/; 2,2/sub 2//sup +/; 0,0/sub 3//sup +/ and 0,0/sub 4//sup +/ states is much improved over the sd-IBM appraoch.

Pæren er faldet langt fra stammen

DEFF Research Database (Denmark)

Haarder, Jon Helt

2013-01-01

Roman: Hassan Preislers vellykkede debutroman udleverer ikke bare multikulti-industrien. Den er også en rablende diagnosticering af det moderne menneskes livsvilkår HASSAN PREISLER BRUN MANDS BYRDE 224 sider, 249,95 Lindhardt og Ringhof Er udkommet 4......Roman: Hassan Preislers vellykkede debutroman udleverer ikke bare multikulti-industrien. Den er også en rablende diagnosticering af det moderne menneskes livsvilkår HASSAN PREISLER BRUN MANDS BYRDE 224 sider, 249,95 Lindhardt og Ringhof Er udkommet 4...

Er Web 2.0 klar til mainstream?

DEFF Research Database (Denmark)

Ivang, Reimer

2009-01-01

BLOG: Spørgsmålene der relateres til Web 2.0 er mange. Men en af de mest signifikante er om netop din virksomhed skal anvende Web 2.0 teknologier? Hvad kan I få ud af det?......BLOG: Spørgsmålene der relateres til Web 2.0 er mange. Men en af de mest signifikante er om netop din virksomhed skal anvende Web 2.0 teknologier? Hvad kan I få ud af det?...

Annual summary report on the surveillance and maintenance activities for the Oak Rige National Laboratory Environmental Restoration Program for fiscal year 1995

International Nuclear Information System (INIS)

1995-11-01

This Annual Summary Report on the Surveillance and Maintenance Activities for the Oak Ridge National Laboratory Environmental Restoration Program for Fiscal Year 1995 was prepared to communicate the accomplishments of the Program during fiscal year 1995. This work was performed under work breakdown structure element 1.4.12.6.1.14.20 (activity data sheet 3314, ''Remedial Action Surveillance and Maintenance''). Publication of this document meets the Life Cycle Baseline milestone date of November 30, 1995. This document provides the accomplishments for both the Remedial Action and Decontamination and Decommissioning Surveillance and Maintenance programs

MIT HJEM ER HVOR MIT HJERTE ER

DEFF Research Database (Denmark)

Høst, Jeppe Engset

2014-01-01

Ideen om at arbejde med det man kalder de stedbundne ressourcer på en ny måde, er relevant på Bornholm hvor events som blandt andet festivalen ’Wonderfestiwall’, strandfesten ’Vang Pier Beach Party’, karnevallet ’Svaneke Beach Party, kokkekonkurrencen ’Sol over Gudhjem’ og filmfestivalen ’Bornsho...

Bird monitoring as an aid to riparian restoration: Findings from the Trinity River in northwestern California

Science.gov (United States)

C. Klamath Bird Observatory and USFS Pacific Southwest Research Station

2013-01-01

The Trinity River Restoration Program began in 2000 with the goal of restoring the Trinity River's salmon and steelhead fisheries, which were severely degraded during the last half-century as a result of dams, water diversions under the Central Valley Project, and land-use practices such as gold mining. The restoration program, as outlined in the U.S. Department...

Fast substation service restoration using intelligent petri-nets models

Energy Technology Data Exchange (ETDEWEB)

Yang, H.T.; Peng, P.C.; Jiang, H.L. [Chung Yuan Christian Univ., Chung Li, Taiwan (China)

2006-07-01

Service restoration of a substation is a stressful and immediate task that must be conducted by system operators following a blackout. Operators, including those of Taiwan Power Company (TPC), normally restore power loads on the basis of their past experiences and engineering heuristics. Due to the significant number of switching operations to be evaluated, a computer-aided decision support system can be quite valuable. In distribution system automation, installation of unmanned substations requires an automated restoration computer system to rapidly devise a switching plan after a fault event. The modeling technique of Petri Nets (PNs) encompasses fault diagnosis of distribution systems, protective scheming of relays, and generic restoration schedule of power transmission systems. Knowledge or configuration about the system concerned can be expressed systematically through a structured model with parallelism and synchronization. This paper proposed a new PNs knowledge representation scheme to achieve a fast, on-line service restoration plan of a substation. The paper described the task of service restoration in a substation as well as the heuristic rules adopted by the dispatchers of the TPC distribution systems. The paper also introduced the topic of Typical PN properties and the proposed matrix operations for PNs reasoning. The proposed basic PNs model for service restoration on the basis of the engineering heuristics were also identified. It was concluded that the proposed approach not only facilitated software programming, but was highly adaptive to the extension or maintenance of the developed programs, arising from the changes of the substation configuration. 18 refs., 1 tab., 8 figs.

An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER.

Science.gov (United States)

Markgraf, Daniel F; Klemm, Robin W; Junker, Mirco; Hannibal-Bach, Hans K; Ejsing, Christer S; Rapoport, Tom A

2014-01-16

Eukaryotic cells store neutral lipids such as triacylglycerol (TAG) in lipid droplets (LDs). Here, we have addressed how LDs are functionally linked to the endoplasmic reticulum (ER). We show that, in S. cerevisiae, LD growth is sustained by LD-localized enzymes. When LDs grow in early stationary phase, the diacylglycerol acyl-transferase Dga1p moves from the ER to LDs and is responsible for all TAG synthesis from diacylglycerol (DAG). During LD breakdown in early exponential phase, an ER membrane protein (Ice2p) facilitates TAG utilization for membrane-lipid synthesis. Ice2p has a cytosolic domain with affinity for LDs and is required for the efficient utilization of LD-derived DAG in the ER. Ice2p breaks a futile cycle on LDs between TAG degradation and synthesis, promoting the rapid relocalization of Dga1p to the ER. Our results show that Ice2p functionally links LDs with the ER and explain how cells switch neutral lipid metabolism from storage to consumption. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

An ER Protein Functionally Couples Neutral Lipid Metabolism on Lipid Droplets to Membrane Lipid Synthesis in the ER

Directory of Open Access Journals (Sweden)

Daniel F. Markgraf

2014-01-01

Full Text Available Eukaryotic cells store neutral lipids such as triacylglycerol (TAG in lipid droplets (LDs. Here, we have addressed how LDs are functionally linked to the endoplasmic reticulum (ER. We show that, in S. cerevisiae, LD growth is sustained by LD-localized enzymes. When LDs grow in early stationary phase, the diacylglycerol acyl-transferase Dga1p moves from the ER to LDs and is responsible for all TAG synthesis from diacylglycerol (DAG. During LD breakdown in early exponential phase, an ER membrane protein (Ice2p facilitates TAG utilization for membrane-lipid synthesis. Ice2p has a cytosolic domain with affinity for LDs and is required for the efficient utilization of LD-derived DAG in the ER. Ice2p breaks a futile cycle on LDs between TAG degradation and synthesis, promoting the rapid relocalization of Dga1p to the ER. Our results show that Ice2p functionally links LDs with the ER and explain how cells switch neutral lipid metabolism from storage to consumption.

Ten year historical perspective of the NOAA damage assessment and restoration program

International Nuclear Information System (INIS)

Burlington, Linda B.

1999-01-01

The United States Oil Pollution Act of 1990 (OPA) was enacted to reduce the probability of oil spills in U.S. waters. A key provision of the legislation enables recovery of damages for restoration of injured natural resources and lost services due to oil spills. The National Oceanic and Atmospheric Administration (NOAA) developed regulations that set out a process for determining the appropriate type and scale of restoration action to accomplish this goal. The restoration plan developed through this process is the basis for an economic claim for natural resource damages. The regulations recognise that various methods, including environmental models, may be used in identifying and quantifying injuries to natural resources and losses of their services and in developing a restoration approach for these injuries. Rather than designating particular assessment measures, NOAA requires each trustee to decide which methodologies are appropriate for each incident, given its particular facts and circumstances. Any procedures chosen must meet the standard in the rule: it must provide information useful for determining restoration needed for an incident, the cost of the method must be commensurate with the quality and quantity of information it is expected to generate, and, of particular significance here, the method must be reliable and valid for the particular incident. This paper describes how methods are selected, how they might be used, and what legal standards would be applied should these methods be used as evidence an litigation. (Author)

ER Stress and Lipid Metabolism in Adipocytes

Directory of Open Access Journals (Sweden)

Beth S. Zha

2012-01-01

Full Text Available The role of endoplasmic reticulum (ER stress is a rapidly emerging field of interest in the pathogenesis of metabolic diseases. Recent studies have shown that chronic activation of ER stress is closely linked to dysregulation of lipid metabolism in several metabolically important cells including hepatocytes, macrophages, β-cells, and adipocytes. Adipocytes are one of the major cell types involved in the pathogenesis of the metabolic syndrome. Recent advances in dissecting the cellular and molecular mechanisms involved in the regulation of adipogenesis and lipid metabolism indicate that activation of ER stress plays a central role in regulating adipocyte function. In this paper, we discuss the current understanding of the potential role of ER stress in lipid metabolism in adipocytes. In addition, we touch upon the interaction of ER stress and autophagy as well as inflammation. Inhibition of ER stress has the potential of decreasing the pathology in adipose tissue that is seen with energy overbalance.

Ondskaben er fortryllende

DEFF Research Database (Denmark)

Schubart, Rikke

2013-01-01

Indlæg om tv-serien Once Upon a Time (2011-), der hører til genren fairytale fantasy, der blander eventyr og fantasy. Her bliver alle eventyr brugt i en fortælling om alle beboere i en lille by, der ikke ved, at de i virkeligheden er eventyr-karakterer.......Indlæg om tv-serien Once Upon a Time (2011-), der hører til genren fairytale fantasy, der blander eventyr og fantasy. Her bliver alle eventyr brugt i en fortælling om alle beboere i en lille by, der ikke ved, at de i virkeligheden er eventyr-karakterer....

Environmental Restoration and Waste Management (EM) program: An introduction

Energy Technology Data Exchange (ETDEWEB)

1990-12-01

This booklet introduces the reader to the mission and functions of a major new unit within the US Department of Energy (DOE): the Office of Environmental Restoration and Waste Management (EM). The Secretary of Energy established EM in November 1989, implementing a central purpose of DOE's first annual Environmental Restoration and Waste Management Five-Year Plan, which had appeared three months earlier. The contents of this booklet, and their arrangement, reflect the annual update of the Five-Year Plan. The Five-Year Plan supports DOE's strategy for meeting its 30-year compliance and cleanup goal. This strategy involves: focusing DOE's activities on eliminating or reducing known or recognized potential risks to worker and public health and the environment, containing or isolating, removing, or detoxifying onsite and offsite contamination, and developing technology to achieve DOE's environmental goals.

Lessons Learned from the First Decade of Adaptive Management in Comprehensive Everglades Restoration

Directory of Open Access Journals (Sweden)

Andrew J. LoSchiavo

2013-12-01

Full Text Available Although few successful examples of large-scale adaptive management applications are available to ecosystem restoration scientists and managers, examining where and how the components of an adaptive management program have been successfully implemented yields insight into what approaches have and have not worked. We document five key lessons learned during the decade-long development and implementation of the Comprehensive Everglades Restoration Plan (CERP Collaborative Adaptive Management Program that might be useful to other adaptive management practitioners. First, legislative and regulatory authorities that require the development of an adaptive management program are necessary to maintain funding and support to set up and implement adaptive management. Second, integration of adaptive management activities into existing institutional processes, and development of technical guidance, helps to ensure that adaptive management activities are understood and roles and responsibilities are clearly articulated so that adaptive management activities are implemented successfully. Third, a strong applied science framework is critical for establishing a prerestoration ecosystem reference condition and understanding of how the system works, as well as for providing a conduit for incorporating new scientific information into the decision-making process. Fourth, clear identification of uncertainties that pose risks to meeting restoration goals helps with the development of hypothesis-driven strategies to inform restoration planning and implementation. Tools such as management options matrices can provide a coherent way to link hypotheses to specific monitoring efforts and options to adjust implementation if performance goals are not achieved. Fifth, independent external peer review of an adaptive management program provides important feedback critical to maintaining and improving adaptive management implementation for ecosystem restoration. These lessons

Restoring proximal caries lesions conservatively with tunnel restorations.

Science.gov (United States)

Chu, Chun-Hung; Mei, May L; Cheung, Chloe; Nalliah, Romesh P

2013-07-30

The tunnel restoration has been suggested as a conservative alternative to the conventional box preparation for treating proximal caries. The main advantage of tunnel restoration over the conventional box or slot preparation includes being more conservative and increasing tooth integrity and strength by preserving the marginal ridge. However, tunnel restoration is technique-sensitive and can be particularly challenging for inexperienced restorative dentists. Recent advances in technology, such as the contemporary design of dental handpieces with advanced light-emitting diode (LED) and handheld comfort, offer operative dentists better vision, illumination, and maneuverability. The use of magnifying loupes also enhances the visibility of the preparation. The advent of digital radiographic imaging has improved dental imaging and reduced radiation. The new generation of restorative materials has improved mechanical properties. Tunnel restoration can be an option to restore proximal caries if the dentist performs proper case selection and pays attention to the details of the restorative procedures. This paper describes the clinical technique of tunnel restoration and reviews the studies of tunnel restorations.

AFM observation of OMVPE-grown ErP on InP substrates using a new organometal tris(ethylcyclopentadienyl)erbium (Er(EtCp)3)

International Nuclear Information System (INIS)

Akane, T.; Jinno, S.; Yang, Y.; Kuno, T.; Hirata, T.; Isogai, Y.; Watanabe, N.; Fujiwara, Y.; Nakamura, A.; Takeda, Y.

2003-01-01

ErP has been grown on InP(0 0 1) substrates by organometallic vapor phase epitaxy (OMVPE) using a new liquid organic Er source: tris(ethylcyclopentadienyl)erbium (Er(EtCp) 3 ). Morphological change of an ErP layer on InP(0 0 1) is investigated together with that of an overgrown capping InP layer. Optimum growth condition of InP causes islanding on over-monolayer-ErP. A relatively low overgrowth temperature of InP is a key factor for attaining complete capping coverage on ErP

Minimizing waste in environmental restoration

International Nuclear Information System (INIS)

Moos, L.; Thuot, J.R.

1996-01-01

Environmental restoration, decontamination and decommissioning and facility dismantelment projects are not typically known for their waste minimization and pollution prevention efforts. Typical projects are driven by schedules and milestones with little attention given to cost or waste minimization. Conventional wisdom in these projects is that the waste already exists and cannot be reduced or minimized. In fact, however, there are three significant areas where waste and cost can be reduced. Waste reduction can occur in three ways: beneficial reuse or recycling; segregation of waste types; and reducing generation of secondary waste. This paper will discuss several examples of reuse, recycle, segregation, and secondary waste reduction at ANL restoration programs

Preventing Advanced Carious Lesions with Caries Atraumatic Restorative Technique.

Science.gov (United States)

Byrd, Tammi O

2016-06-01

An alternative approach to controlling dental caries and preventing the associated pain, called atraumatic restorative technique (ART), is described for populations in need, where dental hygienists restore decayed teeth with glass ionomer restorations without prior removal of all decayed tooth structure. There are populations whose decay needs are not adequately being met within the current oral health care delivery system. These include those in poverty conditions, vulnerable children, and the elderly who are often in long-term care facilities without adequate resources or opportunities for traditional dentistry. ART provides a viable option for controlling caries and relieving the pain of untreated decay. The purpose of this article is to suggest that the evidence surrounding ART be viewed objectively and that dental hygienists, with additional education in this approach, can contribute to relieving the pain of untreated dental decay. Evidence suggests that teeth can be effectively restored with ART. Dental hygienists represent an appropriate workforce to provide ART with their current background and education combined plus a brief training program; it is suggested that dental hygiene educational programs include ART within the curriculum. Along with dental sealants and fluoride varnish application, ART can be an important component of a comprehensive preventive program to address the unmet needs of vulnerable populations. Copyright © 2016 Elsevier Inc. All rights reserved.

Collaborative restoration effects on forest structure in ponderosa pine-dominated forests of Colorado

Science.gov (United States)

Jeffery B. Cannon; Kevin J. Barrett; Benjamin M. Gannon; Robert N. Addington; Mike A. Battaglia; Paula J. Fornwalt; Gregory H. Aplet; Antony S. Cheng; Jeffrey L. Underhill; Jennifer S. Briggs; Peter M. Brown

2018-01-01

In response to large, severe wildfires in historically fire-adapted forests in the western US, policy initiatives, such as the USDA Forest Service’s Collaborative Forest Landscape Restoration Program (CFLRP), seek to increase the pace and scale of ecological restoration. One required component of this program is collaborative adaptive management, in which monitoring...

Hanford Site performance summary: EM funded programs

International Nuclear Information System (INIS)

Edwards, C.

1995-09-01

Hanford performance at fiscal year end reflects a three percent unfavorable schedule variance ($46.3 million*) which was an improvement over August 1995 ($46.3 million for September versus $65.9 million for August) and is below established reporting thresholds (greater than 3 percent). The majority of the behind schedule condition (53 percent) is attributed to EM-40 (Office of Environmental Restoration [ER]) and is a result of late receipt of funds, procurement delays, and US Army Corps of Engineers (USACE) work planned but not accomplished. Other primary contributors to the behind schedule condition are associated with tank farm upgrades, high-level waste disposal and work for others (support to the US Department of Energy-Headquarters [DOE-HQ]). The remaining behind schedule condition is distributed throughout the remaining Hanford programs and do not share common causes. A breakdown of individuals listed on page 8

American wild celery (Vallisneria americana): Ecological considerations for restoration

Science.gov (United States)

Korschgen, C.E.; Green, W.L.

1988-01-01

The success of vegetation management programs for waterfowl is dependent on knowing the physical and physiological requirements of target species. Lakes and riverine impoundments that contain an abundance of the American wildcelery (Vallisneria americana ) have traditionally been favored by canvasbacks (Aythya valisineria ) and other waterfowl as feeding areas during migration. Information on the ecology of American wildcelery is summarized to serve as a guide for potential wetland restoration projects. Techniques are described for transplanting winter buds. Management programs that employ these techniques should define objectives clearly and evaluate the water regime carefully before initiating major restoration.

Environmental Restoration and Waste Management (EM) program: An introduction

International Nuclear Information System (INIS)

1991-06-01

This booklet introduces the reader to the mission and functions of a major unit within the US Department of Energy (DOE): the Office of Environmental Restoration and Waste Management (EM). The Secretary of Energy established EM in November 198, implementing the first step in fulfilling the central purpose of DOE's annually updated Environmental Restoration and Waste Management Five-Year Plan (FYP). The first FYP had been developed three months earlier. The contents of this booklet, and their arrangement, reflect (and will, it is hoped, serve as a kind of appetizer for) the annual update of the Five-Year Plan. The Five-Year Plan supports DOE's strategy for meeting its 30-year compliance and cleanup goal. This strategy involves: (1) focusing DOE's activities on eliminating or reducing known or recognized potential risks to workers, the public, and the environment; (2) containing or isolating, removing, or detoxifying onsite and offsite contamination; and (3) developing technology to achieve DOE's environmental goals. 101 refs

Hvorfor er sygeplejersker usynlige i offentlige medier?

DEFF Research Database (Denmark)

Joensen, Annemi Lund; Hall, Elisabeth

2015-01-01

Når der er sygeplejerelevante emner til debat i de offentlige medier på Færøerne, bærer debatten præg af sygeplejerskers manglende deltagelse. Sygeplejerskerne er usynlige. Et eksempel på dette er en debat om besparelser inden for ældreomsorgen. Til trods for at besparelsen fik omfattende konsekv...

Adaptively Addressing Uncertainty in Estuarine and Near Coastal Restoration Projects

Energy Technology Data Exchange (ETDEWEB)

Thom, Ronald M.; Williams, Greg D.; Borde, Amy B.; Southard, John A.; Sargeant, Susan L.; Woodruff, Dana L.; Laufle, Jeffrey C.; Glasoe, Stuart

2005-03-01

Restoration projects have an uncertain outcome because of a lack of information about current site conditions, historical disturbance levels, effects of landscape alterations on site development, unpredictable trajectories or patterns of ecosystem structural development, and many other factors. A poor understanding of the factors that control the development and dynamics of a system, such as hydrology, salinity, wave energies, can also lead to an unintended outcome. Finally, lack of experience in restoring certain types of systems (e.g., rare or very fragile habitats) or systems in highly modified situations (e.g., highly urbanized estuaries) makes project outcomes uncertain. Because of these uncertainties, project costs can rise dramatically in an attempt to come closer to project goals. All of the potential sources of error can be addressed to a certain degree through adaptive management. The first step is admitting that these uncertainties can exist, and addressing as many of the uncertainties with planning and directed research prior to implementing the project. The second step is to evaluate uncertainties through hypothesis-driven experiments during project implementation. The third step is to use the monitoring program to evaluate and adjust the project as needed to improve the probability of the project to reach is goal. The fourth and final step is to use the information gained in the project to improve future projects. A framework that includes a clear goal statement, a conceptual model, and an evaluation framework can help in this adaptive restoration process. Projects and programs vary in their application of adaptive management in restoration, and it is very difficult to be highly prescriptive in applying adaptive management to projects that necessarily vary widely in scope, goal, ecosystem characteristics, and uncertainties. Very large ecosystem restoration programs in the Mississippi River delta (Coastal Wetlands Planning, Protection, and Restoration

Restoring proximal caries lesions conservatively with tunnel restorations

Directory of Open Access Journals (Sweden)

Chu CH

2013-07-01

Full Text Available Chun-Hung Chu1, May L Mei,1 Chloe Cheung,1 Romesh P Nalliah2 1Faculty of Dentistry, The University of Hong Kong, Hong Kong, People's Republic of China; 2Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA, USA Abstract: The tunnel restoration has been suggested as a conservative alternative to the conventional box preparation for treating proximal caries. The main advantage of tunnel restoration over the conventional box or slot preparation includes being more conservative and increasing tooth integrity and strength by preserving the marginal ridge. However, tunnel restoration is technique-sensitive and can be particularly challenging for inexperienced restorative dentists. Recent advances in technology, such as the contemporary design of dental handpieces with advanced light-emitting diode (LED and handheld comfort, offer operative dentists better vision, illumination, and maneuverability. The use of magnifying loupes also enhances the visibility of the preparation. The advent of digital radiographic imaging has improved dental imaging and reduced radiation. The new generation of restorative materials has improved mechanical properties. Tunnel restoration can be an option to restore proximal caries if the dentist performs proper case selection and pays attention to the details of the restorative procedures. This paper describes the clinical technique of tunnel restoration and reviews the studies of tunnel restorations. Keywords: operative, practice, tunnel preparation, composite, amalgam, glass ionomer

Health and safety plan for operations performed for the Environmental Restoration Program

Energy Technology Data Exchange (ETDEWEB)

Trippet, W.A. II (IT Corp., (United States)); Reneau, M.; Morton, S.L. (EG and G Idaho, Inc., Idaho Falls, ID (United States))

1992-04-01

This document constitutes the generic health and safety plan for the Environmental Restoration Program (ERP). It addresses the health and safety requirements of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA); Occupational Safety and Health Administration (OSHA) 29 CFR 1910.120 standard; and EG G Idaho, Inc. This plan is a guide to individuals who must complete a health and safety plan for a task performed for the EPR. It contains a task specific addendum that, when completed, specifically addresses task specific health and safety issues. This health and safety plan reduces the time it takes to write a task specific health and safety plan by providing discussions of requirements, guidance on where specific information is located, and specific topics in the Addendum that must be discussed at a task level. This format encourages a complete task specific health and safety plan and a standard for all health and safety plans written for ERP.

Health and safety plan for operations performed for the Environmental Restoration Program

International Nuclear Information System (INIS)

Trippet, W.A. II; Reneau, M.; Morton, S.L.

1992-04-01

This document constitutes the generic health and safety plan for the Environmental Restoration Program (ERP). It addresses the health and safety requirements of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA); Occupational Safety and Health Administration (OSHA) 29 CFR 1910.120 standard; and EG ampersand G Idaho, Inc. This plan is a guide to individuals who must complete a health and safety plan for a task performed for the EPR. It contains a task specific addendum that, when completed, specifically addresses task specific health and safety issues. This health and safety plan reduces the time it takes to write a task specific health and safety plan by providing discussions of requirements, guidance on where specific information is located, and specific topics in the Addendum that must be discussed at a task level. This format encourages a complete task specific health and safety plan and a standard for all health and safety plans written for ERP

Shear bond strength of composite bonded with three adhesives to Er,Cr:YSGG laser-prepared enamel.

Science.gov (United States)

Türkmen, Cafer; Sazak-Oveçoğlu, Hesna; Günday, Mahir; Güngör, Gülşad; Durkan, Meral; Oksüz, Mustafa

2010-06-01

To assess in vitro the shear bond strength of a nanohybrid composite resin bonded with three adhesive systems to enamel surfaces prepared with acid and Er,Cr:YSGG laser etching. Sixty extracted caries- and restoration-free human maxillary central incisors were used. The teeth were sectioned 2 mm below the cementoenamel junction. The crowns were embedded in autopolymerizing acrylic resin with the labial surfaces facing up. The labial surfaces were prepared with 0.5-mm reduction to receive composite veneers. Thirty specimens were etched with Er,Cr:YSGG laser. This group was also divided into three subgroups, and the following three bonding systems were then applied on the laser groups and the other three unlased groups: (1) 37% phosphoric acid etch + Bond 1 primer/adhesive (Pentron); (2) Nano-bond self-etch primer (Pentron) + Nano-bond adhesive (Pentron); and (3) all-in-one adhesive-single dose (Futurabond NR, Voco). All of the groups were restored with a nanohybrid composite resin (Smile, Pentron). Shear bond strength was measured with a Zwick universal test device with a knife-edge loading head. The data were analyzed with two-factor ANOVA. There were no significant differences in shear bond strength between self-etch primer + adhesive and all-in-one adhesive systems for nonetched and laser-etched enamel groups (P > .05). However, bond strength values for the laser-etched + Bond 1 primer/adhesive group (48.00 +/- 13.86 MPa) were significantly higher than the 37% phosphoric acid + Bond 1 primer/adhesive group (38.95 +/- 20.07 MPa) (P enamel surface more effectively than 37% phosphoric acid for subsequent attachment of composite material.

Environmental Restoration Operations Consolidated Quarterly Report: July-September 2016

Energy Technology Data Exchange (ETDEWEB)

Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-01-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented at Sandia National Laboratories, New Mexico (SNL/NM) during the July, August, and September 2016 quarterly reporting period. The Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM are listed in Table I-1. Sections I.2.1 and I.2.2 summarize the work completed during this quarter. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities. Field activities are conducted at the three groundwater AOCs (Burn Site Groundwater [BSG AOC], Technical Area [TA]-V Groundwater [TAVG AOC], and Tijeras Arroyo Groundwater [TAG AOC]). Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) issued a certificate of completion and the sites are in the corrective action complete (CAC) regulatory process. Currently, SWMUs 8 and 58, 68, 149, 154, and 502 are in the CAC regulatory process. Corrective action activities are deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these three sites are active mission facilities. These three active sites are located in TA-III.

Brandulykker er et socialt problem

DEFF Research Database (Denmark)

Leth, Peter Mygind

1999-01-01

Det er de gamle, de syge, de handicappede og alkoholikerne, der brænder inde. Typisk har de tabt en cigaret eller tændstik på tøjet. En del af disse brandulykker opstår på plejehjem og andre institutioner, hvor det ofte er plejepersonalet, der opdager og slukker branden....

Ferske vandområder - Søer

DEFF Research Database (Denmark)

Jensen, J. P.; Jeppesen, E.; Søndergaard, M.

Forord: Denne rapport er udarbej-det af Danmarks Mil-jøunder-søgelser som et led i den lands-dæk-ken-de rapportering af Vand-miljøpla-nens Over-vågningspro-gram. Over-vågningsprogram-met blev iværksat efteråret 1988. Hensigten med Vand-miljøplanens over-vågningsprogram er at undersøge effekten af......-miljøet med nærings-salte. Danmarks Miljøundersø-gelser har som sektor-forskningsinstitu-tion i Miljø- og Energiministeriet til opgave at forbedre og styrke det fagli-ge grundlag for de mil-jøpolitiske prioriteringer og beslut-ninger. En væsentlig del af denne opgave er overvågning af miljø og natur. Det er...

Arctigenin alleviates ER stress via activating AMPK

Science.gov (United States)

Gu, Yuan; Sun, Xiao-xiao; Ye, Ji-ming; He, Li; Yan, Shou-sheng; Zhang, Hao-hao; Hu, Li-hong; Yuan, Jun-ying; Yu, Qiang

2012-01-01

Aim: To investigate the protective effects of arctigenin (ATG), a phenylpropanoid dibenzylbutyrolactone lignan from Arctium lappa L (Compositae), against ER stress in vitro and the underlying mechanisms. Methods: A cell-based screening assay for ER stress regulators was established. Cell viability was measured using MTT assay. PCR and Western blotting were used to analyze gene and protein expression. Silencing of the CaMKKβ, LKB1, and AMPKα1 genes was achieved by RNA interference (RNAi). An ATP bioluminescent assay kit was employed to measure the intracellular ATP levels. Results: ATG (2.5, 5 and 10 μmol/L) inhibited cell death and unfolded protein response (UPR) in a concentration-dependent manner in cells treated with the ER stress inducer brefeldin A (100 nmol/L). ATG (1, 5 and 10 μmol/L) significantly attenuated protein synthesis in cells through inhibiting mTOR-p70S6K signaling and eEF2 activity, which were partially reversed by silencing AMPKα1 with RNAi. ATG (1-50 μmol/L) reduced intracellular ATP level and activated AMPK through inhibiting complex I-mediated respiration. Pretreatment of cells with the AMPK inhibitor compound C (25 μmol/L) rescued the inhibitory effects of ATG on ER stress. Furthermore, ATG (2.5 and 5 μmol/L) efficiently activated AMPK and reduced the ER stress and cell death induced by palmitate (2 mmol/L) in INS-1 β cells. Conclusion: ATG is an effective ER stress alleviator, which protects cells against ER stress through activating AMPK, thus attenuating protein translation and reducing ER load. PMID:22705729

Hvad er ledelse af brugerinddragelse?

DEFF Research Database (Denmark)

Holm-Petersen, Christina; Navne, Laura Emdal

2015-01-01

Brugerinddragelse i det danske sundhedsvæsen står højt på den politiske dagsorden, men det er stadig en udfordring at implementere visionen i klinisk praksis. Ledelse af brugerinddragelse bliver aktuelt udpeget som en central nøgle til at føre visionen ud i livet. Samtidig er der kun relativt lidt......, at brugerinddragelse skal implementeres i en verden, hvor der allerede er en række andre mål tilstede. En central ledelsesudfordring er derfor, at nogle af målene med brugerinddragelse forudsætter nye måder at organisere ikke bare arbejdet og kompetencer på, men også relationer til patienter og pårørende. En væsentlig...... that organize relations Patient involvement in the health services in Denmark is high on the political agenda, though continues to be a challenge to implement. It is increasingly said that leadership is crucial to the implementation process. However, research into the role of leaders in patient involvement...

Experiences in reconciling risk management and restorative justice: how circles of support and accountability work restoratively in the risk society.

Science.gov (United States)

Hannem, Stacey

2013-03-01

Circles of Support and Accountability (COSA) is a restorative justice-based model that originated in Canada in the mid-1990s for the postincarceration reintegration of those who have offended sexually. Although the roots of COSA are in restorative justice philosophy, the program has also found favour, to some degree, with organisations such as police services and corrections that are traditionally concerned more with protecting community safety than with the ideals of restorative justice. Informed by the author's research and personal experience as a COSA volunteer, and analysis of recent and historical representations of COSA, this article explores theoretically how the development of the COSA initiative has been influenced by the seemingly disparate concerns of both the restorative justice and community protection movements, and examines the importance of balancing these paradigms in the everyday practices of circles.

Er3+ infrared fluorescence affected by spatial distribution synchronicity of Ba2+ and Er3+ in Er3+-doped BaO–SiO2 glasses

Directory of Open Access Journals (Sweden)

Atsunobu Masuno

2016-02-01

Full Text Available Glasses with the composition xBaO–(99.9 − xSiO2–0.1ErO3/2 (0 ≤x ≤ 34.9 were fabricated by a levitation technique. The glasses in the immiscibility region were opaque due to chemical inhomogeneity, while the other glasses were colorless and transparent. The scanning electron microscope observations and electron probe microanalysis scan profiles revealed that more Er3+ ions were preferentially distributed in the regions where more Ba2+ ions existed in the chemically inhomogeneous glasses. The synchronicity of the spatial distributions of the two ions initially increased with increasing x and then decreased when the Ba2+ concentration exceeded a certain value. The peak shape and lifetime of the fluorescence at 1.55 μm depended on x as well as the spatial distribution of both ions. These results indicate that although ErOn polyhedra are preferentially coordinated with Ba2+ ions and their local structure is affected by the coordination of Ba2+, there is a maximum in the amount of Ba2+ ions that can coordinate ErOn polyhedra since the available space for Ba2+ ions is limited. These findings provide us with efficient ways to design the chemical composition of glasses with superior Er3+ fluorescence properties for optical communication network systems.

LANL environmental restoration site ranking system: System description. Final report

International Nuclear Information System (INIS)

Merkhofer, L.; Kann, A.; Voth, M.

1992-01-01

The basic structure of the LANL Environmental Restoration (ER) Site Ranking System and its use are described in this document. A related document, Instructions for Generating Inputs for the LANL ER Site Ranking System, contains detailed descriptions of the methods by which necessary inputs for the system will be generated. LANL has long recognized the need to provide a consistent basis for comparing the risks and other adverse consequences associated with the various waste problems at the Lab. The LANL ER Site Ranking System is being developed to help address this need. The specific purpose of the system is to help improve, defend, and explain prioritization decisions at the Potential Release Site (PRS) and Operable Unit (OU) level. The precise relationship of the Site Ranking System to the planning and overall budget processes is yet to be determined, as the system is still evolving. Generally speaking, the Site Ranking System will be used as a decision aid. That is, the system will be used to aid in the planning and budgetary decision-making process. It will never be used alone to make decisions. Like all models, the system can provide only a partial and approximate accounting of the factors important to budget and planning decisions. Decision makers at LANL will have to consider factors outside of the formal system when making final choices. Some of these other factors are regulatory requirements, DOE policy, and public concern. The main value of the site ranking system, therefore, is not the precise numbers it generates, but rather the general insights it provides

LANL environmental restoration site ranking system: System description. Final report

Energy Technology Data Exchange (ETDEWEB)

Merkhofer, L.; Kann, A.; Voth, M. [Applied Decision Analysis, Inc., Menlo Park, CA (United States)

1992-10-13

The basic structure of the LANL Environmental Restoration (ER) Site Ranking System and its use are described in this document. A related document, Instructions for Generating Inputs for the LANL ER Site Ranking System, contains detailed descriptions of the methods by which necessary inputs for the system will be generated. LANL has long recognized the need to provide a consistent basis for comparing the risks and other adverse consequences associated with the various waste problems at the Lab. The LANL ER Site Ranking System is being developed to help address this need. The specific purpose of the system is to help improve, defend, and explain prioritization decisions at the Potential Release Site (PRS) and Operable Unit (OU) level. The precise relationship of the Site Ranking System to the planning and overall budget processes is yet to be determined, as the system is still evolving. Generally speaking, the Site Ranking System will be used as a decision aid. That is, the system will be used to aid in the planning and budgetary decision-making process. It will never be used alone to make decisions. Like all models, the system can provide only a partial and approximate accounting of the factors important to budget and planning decisions. Decision makers at LANL will have to consider factors outside of the formal system when making final choices. Some of these other factors are regulatory requirements, DOE policy, and public concern. The main value of the site ranking system, therefore, is not the precise numbers it generates, but rather the general insights it provides.

Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation

Science.gov (United States)

Chhunchha, Bhavana; Fatma, Nigar; Kubo, Eri; Rai, Prerana; Singh, Sanjay P.

2013-01-01

Oxidative stress and endoplasmic reticulum (ER) stress are emerging as crucial events in the etiopathology of many neurodegenerative diseases. While the neuroprotective contributions of the dietary compound curcumin has been recognized, the molecular mechanisms underlying curcumin's neuroprotection under oxidative and ER stresses remains elusive. Herein, we show that curcumin protects HT22 from oxidative and ER stresses evoked by the hypoxia (1% O2 or CoCl2 treatment) by enhancing peroxiredoxin 6 (Prdx6) expression. Cells exposed to CoCl2 displayed reduced expression of Prdx6 with higher reactive oxygen species (ROS) expression and activation of NF-κB with IκB phosphorylation. When NF-κB activity was blocked by using SN50, an inhibitor of NF-κB, or cells treated with curcumin, the repression of Prdx6 expression was restored, suggesting the involvement of NF-κB in modulating Prdx6 expression. These cells were enriched with an accumulation of ER stress proteins, C/EBP homologous protein (CHOP), GRP/78, and calreticulin, and had activated states of caspases 12, 9, and 3. Reinforced expression of Prdx6 in HT22 cells by curcumin reestablished survival signaling by reducing propagation of ROS and blunting ER stress signaling. Intriguingly, knockdown of Prdx6 by antisense revealed that loss of Prdx6 contributed to cell death by sustaining enhanced levels of ER stress-responsive proapoptotic proteins, which was due to elevated ROS production, suggesting that Prdx6 deficiency is a cause of initiation of ROS-mediated ER stress-induced apoptosis. We propose that using curcumin to reinforce the naturally occurring Prdx6 expression and attenuate ROS-based ER stress and NF-κB-mediated aberrant signaling improves cell survival and may provide an avenue to treat and/or postpone diseases associated with ROS or ER stress. PMID:23364261

Den rige personlighed er livsduelig

DEFF Research Database (Denmark)

Holm, Claus

2015-01-01

For omtrent 160 år siden formulerede Karl Marx forestillingen om en rig individualitet som det kommunistiske samfunds individideal. I dag får forestillingen relevans. Lyder det lidt besynderligt, er det ikke mærkeligt. For de fleste af os går næppe rundt og tror, at vi er lige på trapperne til...

Hvilke Dødehavstekster er "sekteriske"?

DEFF Research Database (Denmark)

Holst, Søren

2003-01-01

Skønt Dødehavsrullerne antageligt tilhørte en gruppering, der boede i Qumran, tyder alt på, at mange af teksterne er forfattet andre steder. Artiklen undersøger den særlige sprogbrug, som antageligt er typisk for Qumran-samfundet, og som præger forbavsende få af tekserne. En meget stor del af...

Humor er en alvorlig sag

DEFF Research Database (Denmark)

Søltoft, Pia

2016-01-01

I modsætning til ironi er humor for Kierkegaard fællesskabsgivende – ironikeren hævder sig selv, men humoristen har sympati med den, man ler med. Humor er hos Kierkegaard udtryk for, at humoristen forliger sig med tilværelsen og dens luner, og dermed grænser humoren hos Kierkegaard op til det...

Employer branding er også intern kommunikation

DEFF Research Database (Denmark)

Hansen, Heidi

2016-01-01

I videnssamfundet og serviceøkonomien er medarbejderne virksomhedens vigtigste ressource, men milleniumgenerationen er ikke trofaste overfor deres arbejdsplads – de har typisk 15-20 jobs i løbet af deres livstid. Et stærkt employer brand bidrager til at fastholde medarbejdere – og dermed...... kompetencer – i virksomheden, og medarbejderne er dermed en central målgruppe for employer branding....

Hvorfor er danske fødevarer dyre?

DEFF Research Database (Denmark)

Hansen, Henning Otte

2015-01-01

De danske fødevarepriser er generelt høje set i forhold til resten af EU og også i forhold til lande uden for EU. Overordnet set er der en række forklaringer på internationale prisforskelle, og der er også flere mulige årsager til de høje danske fødevarepriser. Forskelle i moms, kvalitet...

South Bay Salt Pond Tidal Marsh Restoration at Pond A17 Project

Science.gov (United States)

Information about the SFBWQP South Bay Salt Pond Tidal Marsh Restoration at Pond A17 Project, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

A Landscape-level Model for Ecosystem Restoration in the San Francisco Estuary and Its Watershed

Directory of Open Access Journals (Sweden)

Wim Kimmerer

2005-03-01

Full Text Available The CALFED Bay-Delta Program is an ambitious effort to restore ecosystems and improve reliability of ecosystem services in California’s Central Valley. Key issues for CALFED and its Ecosystem Restoration Program (ERP include (1 meeting societal demand for multiple, potentially conflicting ecosystem services; (2 the tradeoff among more or less environmentally intrusive approaches to solving problems; (3 whether restoration should focus at the ecosystem level or on individual species; (4 the appropriate response to uncertainty; and (5 the tension between action and investigation. A long-term, landscape-scale perspective is essential for framing the scientific questions underlying these broad issues. We introduce a landscape-scale conceptual model that illustrates linkages, including material flows and animal migration, among the major ecosystem components being described in detail in a series of review papers. This model shows how linkages between ecosystem components result in remote consequences of locally applied restoration actions. The network of linkages is made more complicated by human interventions, which add components not previously a part of the landscape (e.g., salmonid hatcheries and alter or even reverse causal relations. A landscape perspective also helps identify conceptual gaps in CALFED’s restoration strategy, such as climate change and human population growth, which should be explicitly considered in forecasts of the long-term prospects for restoration. A landscape perspective is no panacea; in particular, the effects of restoration at this scale will be difficult to detect. Nevertheless, we advocate integrating investigations of processes at nested, smaller scales as an approach for evaluating effects of individual restoration actions and of the entire program. We believe CALFED and other large restoration programs will be most successful if they are able to integrate both societal expectations and scientific study at the

Short-term ecological consequences of collaborative restoration treatments in ponderosa pine forests of Colorado

Science.gov (United States)

Jennifer S. Briggs; Paula J. Fornwalt; Jonas A. Feinstein

2017-01-01

Ecological restoration treatments are being implemented at an increasing rate in ponderosa pine and other dry conifer forests across the western United States, via the USDA Forest Service’s Collaborative Forest Landscape Restoration (CFLR) program. In this program, collaborative stakeholder groups work with National Forests (NFs) to adaptively implement and monitor...

Ytringsfriheden er ikke nødvendig

DEFF Research Database (Denmark)

Lauritzen, Pia

2008-01-01

nemlig godt konstatere, at ytringsfriheden ikke er nødvendig uden dermed at give afkald på frihed og demokrati.Vi kan oven i købet mene, at ytringsfriheden ophører med at være frihed, når vi betragter den som nødvendig. Og det er lige nøjagtig det, jeg efterlyser: at vi bruger filosoffer som Immanuel...... Kant og Luigi Pareyson til at forstå, at friheden er betydelig mere kompleks, end vi gør den til i øjeblikket....

TCSP ER-2 DOPPLER RADAR (EDOP) V1

Data.gov (United States)