WorldWideScience

Sample records for restarted arnoldi method

  1. Re-starting an Arnoldi iteration

    Energy Technology Data Exchange (ETDEWEB)

    Lehoucq, R.B. [Argonne National Lab., IL (United States)

    1996-12-31

    The Arnoldi iteration is an efficient procedure for approximating a subset of the eigensystem of a large sparse n x n matrix A. The iteration produces a partial orthogonal reduction of A into an upper Hessenberg matrix H{sub m} of order m. The eigenvalues of this small matrix H{sub m} are used to approximate a subset of the eigenvalues of the large matrix A. The eigenvalues of H{sub m} improve as estimates to those of A as m increases. Unfortunately, so does the cost and storage of the reduction. The idea of re-starting the Arnoldi iteration is motivated by the prohibitive cost associated with building a large factorization.

  2. IMPROVING EIGENVECTORS IN ARNOLDI'S METHOD

    Institute of Scientific and Technical Information of China (English)

    Zhong-xiao Jia; Ludwig Elsner

    2000-01-01

    The Ritz vectors obtained by Arnoldi's method may not be good approximations and even may not converge even if the corresponding Ritz values do. In order to improve the quality of Ritz vectors and enhance the efficiency of Arnoldi type algorithms, we propose a strategy that uses Ritz values obtained from an m-dimensional Krylov subspace but chooses modified approximate eigenvectors in an (m+1)-dimensional Krylov subspace. Residual norm of each new approximate eigenpair is minimal over the span of the Ritz vector and the (m+1)th basis vector,which is available when the m-step Arnoldi process is run. The resulting modi-fied m-step Arnoldi method is better than the standard m-step one in theory and cheaper than the standard (m+1)-step one. Based on this strategy, we present a modified m-step restarted Arnoldi algorithm. Numerical examples show that the modified m-step restarted algorithm and its version with Chebyshev acceleration are often considerably more efficient than the standard (m + 1)-step restarted ones.

  3. Convergence of Arnoldi method

    Energy Technology Data Exchange (ETDEWEB)

    Nevanlinna, O. [Helsinki Univ. of Technology, Espoo (Finland)

    1994-12-31

    This note summarizes some results on (a monitored version of) the Arnoldi method in Hilbert spaces. The interest in working in infinite dimensional spaces comes partly from the fact that only then can one have meaningful asymptotical statements (which hopefully give some light to the convergence of Arnoldi in large dimensional problems with iteration indices far less than the dimension).

  4. Augmented Arnoldi-Tikhonov Regularization Methods for Solving Large-Scale Linear Ill-Posed Systems

    Directory of Open Access Journals (Sweden)

    Yiqin Lin

    2013-01-01

    Full Text Available We propose an augmented Arnoldi-Tikhonov regularization method for the solution of large-scale linear ill-posed systems. This method augments the Krylov subspace by a user-supplied low-dimensional subspace, which contains a rough approximation of the desired solution. The augmentation is implemented by a modified Arnoldi process. Some useful results are also presented. Numerical experiments illustrate that the augmented method outperforms the corresponding method without augmentation on some real-world examples.

  5. Computing a partial Schur factorization of nonlinear eigenvalue problems using the infinite Arnoldi method

    CERN Document Server

    Jarlebring, Elias; Michiels, Wim

    2012-01-01

    The partial Schur factorization can be used to represent several eigenpairs of a matrix in a numerically robust way. Different adaptions of the Arnoldi method are often used to compute partial Schur factorizations. We propose here a technique to compute a partial Schur factorization of a nonlinear eigenvalue problem (NEP). The technique is inspired by the algorithm in [8], now called the infinite Arnoldi method. The infinite Arnoldi method is a method designed for NEPs, and can be interpreted as Arnoldi's method applied to a linear infinite-dimensional operator, whose reciprocal eigenvalues are the solutions to the NEP. As a first result we show that the invariant pairs of the operator are equivalent to invariant pairs of the NEP. We characterize the structure of the invariant pairs of the operator and show how one can carry out a modification of the infinite Arnoldi method by respecting the structure. This also allows us to naturally add the feature known as locking. We nest this algorithm with an outer iter...

  6. 解大规模非对称矩阵特征问题的精化Arnoldi方法的一种变形%A VARIANT OF THE REFINED ARNOLDI METHOD FOR LARGE SCALE MATRIX EIGENPROBLEMS

    Institute of Scientific and Technical Information of China (English)

    贾仲孝; 陈桂芝

    2003-01-01

    The refined Arnoldi method proposed by Jia is used for computing some eigen-pairs of large matrices. In contrast to the Arnoldi method, the fundamental dif-ference is that the refined method seeks certain refined Ritz vectors, which aredifferent from the Ritz vectors obtained by the Arnoldi method, from a projection space with minimal residuals to approximate the desired eigenvectors. In com-parison with the Ritz vectors, the refined Ritz vectors are guaranteed to converge theoretically and can converge much faster numerically. In this paper we propose to replace the Ritz values, obtained by the Arnoldi method with respect to a Krylovsubspace, by the ones obtained with respect to the subspace spanned by the refined Ritz vectors. We discuss how to compute these new approximations cheaply and reliably. Theoretical error bounds between the original Ritz values and the new Ritz values are established. Finally, we present a variant of the refined Arnoldi al-gorithm for an augmented Krylov subspace and discuss restarting issue. Numerical results confirm efficiency of the new algorithm.

  7. Adaptive rational block Arnoldi methods for model reductions in large-scale MIMO dynamical systems

    Directory of Open Access Journals (Sweden)

    Khalide Jbilou

    2016-04-01

    Full Text Available In recent years, a great interest has been shown towards Krylov subspace techniques applied to model order reduction of large-scale dynamical systems. A special interest has been devoted to single-input single-output (SISO systems by using moment matching techniques based on Arnoldi or Lanczos algorithms. In this paper, we consider multiple-input multiple-output (MIMO dynamical systems and introduce the rational block Arnoldi process to design low order dynamical systems that are close in some sense to the original MIMO dynamical system. Rational Krylov subspace methods are based on the choice of suitable shifts that are selected a priori or adaptively. In this paper, we propose an adaptive selection of those shifts and show the efficiency of this approach in our numerical tests. We also give some new block Arnoldi-like relations that are used to propose an upper bound for the norm of the error on the transfer function.

  8. OBJECT-ORIENTED MULTI-SPECTRUM TRANSFORMATION IMPLICIT RESTARTED ARNOLDI ALGORITHM%面向对象的多谱变换隐式重启动Arnoldi算法

    Institute of Scientific and Technical Information of China (English)

    励刚; 苏寅生; 陈陈

    2001-01-01

    In the structure design of the multi-spectrum transformation implicit restarted Arnoldi (IRA) algorithm, this paper firstly decouples the main part of the IRA algorithm from multi-spectrum transformations by adopting the functional expressions, and then produces the IRA and spectrum transformation objects which are independent of each other. Furthermore, by applying the design pattern approach, and according to the relationship between the stable point-hot point structure and the template-hook structure of design patterns, a novel multi-spectrum transformation IRA algorithm structure is finally given based on design patterns. The real applications of this algorithm structure show its advantages enough in expandability, reusability and calculation efficiency of software system.%在多谱变换隐式重启动Arnoldi(IRA)算法结构设计中,采用泛函表述实现了谱变换和IRA算法解耦,产生了相对独立的IRA对象和多种谱变换对象。然后应用设计模式概念,根据多谱变换下IRA算法凝固点—热点结构和设计模式模板—挂钩结构的对应关系,提出基于设计模式结构的多谱变换IRA算法组合结构。该算法结构的实际应用充分证明了其在软件系统可伸展性、可重用性和计算效率方面的优势。

  9. Subspace Expansion in the Shift-Invert Residual Arnoldi Method and the Jacobi--Davidson Method: Theory and Algorithms

    CERN Document Server

    Jia, Zhongxiao

    2011-01-01

    We give a quantitative analysis of the Shift-Invert Residual Arnoldi (SIRA) method and the Jacobi--Davidson (JD) method for computing a simple eigenvalue nearest to a target $\\sigma$ and/or the associated eigenvector. In SIRA and JD, subspace expansion vectors at each step are obtained by solving certain (different) inner linear systems, respectively. We show that (i) SIRA and the JD method with the fixed target $\\sigma$ are mathematically equivalent when the inner linear systems are solved exactly and (ii) the inexact SIRA is asymptotically equivalent to the JD method when the inner linear systems in them are solved with the same accuracy. Remarkably, we prove that the inexact SIRA and JD methods mimic the exact SIRA well provided that the inner linear systems are iteratively solved with a fixed {\\em low} or {\\em modest} accuracy. It is opposed to the inexact Shift-Invert Arnoldi (SIA) method, where the inner linear system involved must be solved with very high accuracy whenever the approximate eigenpair is ...

  10. A Restarted Conjugate Gradient Method for Ill-posed Problems

    Institute of Scientific and Technical Information of China (English)

    Yan-fei Wang

    2003-01-01

    This paper presents a restarted conjugate gradient iterative algorithm for solving ill-posed problems.The damped Morozov's discrepancy principle is used as a stopping rule. Numerical experiments are given to illustrate the efficiency of the method.

  11. Thick restarting of the Davidson method: An extension to implicit restarting

    Energy Technology Data Exchange (ETDEWEB)

    Stathopoulos, A.; Yousef Saad; Wu, Kesheng [Univ. of Minnesota, Minneapolis, MN (United States)

    1996-12-31

    The solution of the large, sparse, eigenvalue problem Ax = {lambda}x, for a few eigenpairs is central to many scientific applications. The Arnoldi method, and its equivalent in the symmetric case the Lanczos method, have been the traditional approach to solving these problems. Preconditioning, through some shift-and-invert technique, is frequently employed, because of the difficulty of these problems. A different approach is followed by the Generalized Davidson (GD) method which is a popular preconditioned variant of the Lanczos iteration. Instead of using a three-term recurrence to build an orthonormal basis for the Krylov subspace, the GD algorithm obtains the next basis vector by explicitly orthogonalizing the preconditioned residual (M - {lambda}I){sup -1} (A - {lambda}I)x against the existing basis. A straightforward extension to the non-symmetric case has also been studied in. The GD method can be regarded as a way of improving convergence and robustness at the expense of a more complicated step.

  12. A new Arnoldi approach for polynomial eigenproblems

    Energy Technology Data Exchange (ETDEWEB)

    Raeven, F.A.

    1996-12-31

    In this paper we introduce a new generalization of the method of Arnoldi for matrix polynomials. The new approach is compared with the approach of rewriting the polynomial problem into a linear eigenproblem and applying the standard method of Arnoldi to the linearised problem. The algorithm that can be applied directly to the polynomial eigenproblem turns out to be more efficient, both in storage and in computation.

  13. An Efficient Variant of the Restarted Shifted GMRES Method for Solving Shifted Linear Systems

    Institute of Scientific and Technical Information of China (English)

    Akira IMAKURA; Tomohiro SOGABE; Shaoliang ZHANG

    2013-01-01

    We investigate the restart of the Restarted Shifted GMRES method for solving shifted linear systems.Recently the variant of the GMRES(m) method with the unfixed update has been proposed to improve the convergence of the GMRES(m) method for solving linear systems,and shown to have an efficient convergence property.In this paper,by applying the unfixed update to the Restarted Shifted GMRES method,we propose a variant of the Restarted Shifted GMRES method.We show a potentiality for efficient convergence within the variant by some numerical results.

  14. Optimal Rapid Restart of Heuristic Methods of NP Hard Problems

    Institute of Scientific and Technical Information of China (English)

    侯越先; 王芳

    2004-01-01

    Many heuristic search methods exhibit a remarkable variability in the time required to solve some particular problem instances. Their cost distributions are often heavy-tailed. It has been demonstrated that, in most cases, rapid restart (RR) method can prominently suppress the heavy-tailed nature of the instances and improve computation efficiency. However, it is usually time-consuming to check whether an algorithm on a specific instance is heavy-tailed or not. Moreover, if the heavy-tailed distribution is confirmed and the RR method is relevant, an optimal RR threshold should be chosen to facilitate the RR mechanism. In this paper, an approximate approach is proposed to quickly check whether an algorithm on a specific instance is heavy-tailed or not.The method is realized by means of calculating the maximal Lyapunov exponent of its generic running trace.Then a statistical formula to estimate the optimal RR threshold is educed. The method is based on common nonparametric estimation, e. g. , Kernel estimation. Two heuristic methods are selected to verify our method. The experimental results are consistent with the theoretical consideration perfectly.

  15. EvArnoldi: A New Algorithm for Large-Scale Eigenvalue Problems.

    Science.gov (United States)

    Tal-Ezer, Hillel

    2016-05-19

    Eigenvalues and eigenvectors are an essential theme in numerical linear algebra. Their study is mainly motivated by their high importance in a wide range of applications. Knowledge of eigenvalues is essential in quantum molecular science. Solutions of the Schrödinger equation for the electrons composing the molecule are the basis of electronic structure theory. Electronic eigenvalues compose the potential energy surfaces for nuclear motion. The eigenvectors allow calculation of diople transition matrix elements, the core of spectroscopy. The vibrational dynamics molecule also requires knowledge of the eigenvalues of the vibrational Hamiltonian. Typically in these problems, the dimension of Hilbert space is huge. Practically, only a small subset of eigenvalues is required. In this paper, we present a highly efficient algorithm, named EvArnoldi, for solving the large-scale eigenvalues problem. The algorithm, in its basic formulation, is mathematically equivalent to ARPACK ( Sorensen , D. C. Implicitly Restarted Arnoldi/Lanczos Methods for Large Scale Eigenvalue Calculations ; Springer , 1997 ; Lehoucq , R. B. ; Sorensen , D. C. SIAM Journal on Matrix Analysis and Applications 1996 , 17 , 789 ; Calvetti , D. ; Reichel , L. ; Sorensen , D. C. Electronic Transactions on Numerical Analysis 1994 , 2 , 21 ) (or Eigs of Matlab) but significantly simpler.

  16. Markov Renewal Methods in Restart Problems in Complex Systems

    DEFF Research Database (Denmark)

    Asmussen, Søren; Lipsky, Lester; Thompson, Stephen

    A task with ideal execution time L such as the execution of a computer program or the transmission of a file on a data link may fail, and the task then needs to be restarted. The task is handled by a complex system with features similar to the ones in classical reliability: failures may...... be mitigated by using server redundancy in parallel or k-out-of-n arrangements, standbys may be cold or warm, one or more repairmen may take care of failed components, etc. The total task time X (including restarts and pauses in failed states) is investigated with particular emphasis on the tail P(X > x......). A general alternating Markov renewal model is proposed and an asymptotic exponential form P(X > x) ∼ Ce−γx identified for the case of a deterministic task time L ≡ `. The rate γ is given by equating the spectral radius of a certain matrix to 1, and the asymptotic form of γ = γ(`) as ` → ∞ is derived...

  17. Short-recurrence Krylov subspace methods for the overlap Dirac operator at nonzero chemical potential

    CERN Document Server

    Bloch, Jacques C R; Frommer, Andreas; Heybrock, Simon; Schaefer, Katrin; Wettig, Tilo

    2009-01-01

    The overlap operator in lattice QCD requires the computation of the sign function of a matrix, which is non-Hermitian in the presence of a quark chemical potential. In previous work we introduced an Arnoldi-based Krylov subspace approximation, which uses long recurrences. Even after the deflation of critical eigenvalues, the low efficiency of the method restricts its application to small lattices. Here we propose new short-recurrence methods which strongly enhance the efficiency of the computational method. Using rational approximations to the sign function we introduce two variants, based on the restarted Arnoldi process and on the two-sided Lanczos method, respectively, which become very efficient when combined with multishift solvers. Alternatively, in the variant based on the two-sided Lanczos method the sign function can be evaluated directly. We present numerical results which compare the efficiencies of a restarted Arnoldi-based method and the direct two-sided Lanczos approximation for various lattice ...

  18. An asynchronous writing method for restart files in the gysela code in prevision of exascale systems*

    Directory of Open Access Journals (Sweden)

    Thomine O.

    2013-12-01

    Full Text Available The present work deals with an optimization procedure developed in the full-f global GYrokinetic SEmi-LAgrangian code (GYSELA. Optimizing the writing of the restart files is necessary to reduce the computing impact of crashes. These files require a very large memory space, and particularly so for very large mesh sizes. The limited bandwidth of the data pipe between the comput- ing nodes and the storage system induces a non-scalable part in the GYSELA code, which increases with the mesh size. Indeed the transfer time of RAM to data depends linearly on the files size. The necessity of non synchronized writing-in-file procedure is therefore crucial. A new GYSELA module has been developed. This asynchronous procedure allows the frequent writ- ing of the restart files, whilst preventing a severe slowing down due to the limited writing bandwidth. This method has been improved to generate a checksum control of the restart files, and automatically rerun the code in case of a crash for any cause.

  19. Efficient periodic band diagram computation using a finite element method, Arnoldi eigensolver and sparse linear system solver

    CERN Document Server

    Garnier, Romain; Pascal, Olivier

    2014-01-01

    We present here a Finite Element Method devoted to the simulation of 3D periodic structures of arbitrary geometry. The numerical method based on ARPACK and PARDISO libraries, is discussed with the aim of extracting the eigenmodes of periodical structures and thus establishing their frequency band gaps. Simulation parameters and the computational optimization are the focus. Resolution will be used to characterize EBG (Electromagnetic Band Gap) structures, such as plasma rods and metallic cubes.

  20. Applications of implicit restarting in optimization and control Dan Sorensen

    Energy Technology Data Exchange (ETDEWEB)

    Sorensen, D. [Rice Univ., Houston, TX (United States)

    1996-12-31

    Implicit restarting is a technique for combining the implicitly shifted QR mechanism with a k-step Arnoldi or Lanczos factorization to obtain a truncated form of the implicitly shifted QR-iteration suitable for large scale eigenvalue problems. The software package ARPACK based upon this technique has been successfully used to solve large scale symmetric and nonsymmetric (generalized) eigenvalue problems arising from a variety of applications.

  1. Global Convergence of a New restarting Conjugate Gradient Method for Nonlinear Optimizations

    Institute of Scientific and Technical Information of China (English)

    SUNQing-ying

    2003-01-01

    Conjugate gradient optimization algorithms depend on the search directions.with different choices for the parameters in the search directions.In this note,by combining the nice numerical performance of PR and HS methods with the global convergence property of the class of conjugate gradient methods presented by HU and STOREY(1991),a class of new restarting conjugate gradient methods is presented.Global convergences of the new method with two kinds of common line searches,are proved .Firstly,it is shown that,using reverse modulus of continuity funciton and forcing function,the new method for solving unconstrained optimization can work for a continously differentiable function with Curry-Altman's step size rule and a bounded level set .Secondly,by using comparing technique,some general convergence propecties of the new method with other kind of step size rule are established,Numerical experiments show that the new method is efficient by comparing with FR conjugate gradient method.

  2. Efficient two-dimensional magnetotellurics modelling using implicitly restarted Lanczos method

    Indian Academy of Sciences (India)

    Krishna Kumar; Pravin K Gupta; Sri Niwas

    2011-08-01

    This paper presents an efficient algorithm, FDA2DMT (Free Decay Analysis for 2D Magnetotellurics (MT)), based on eigenmode approach to solve the relevant partial differential equation, for forward computation of two-dimensional (2D) responses. The main advantage of this approach lies in the fact that only a small subset of eigenvalues and corresponding eigenvectors are required for satisfactory results. This small subset (pre-specified number) of eigenmodes are obtained using shift and invert implementation of Implicitly Restarted Lanczos Method (IRLM). It has been established by experimentation that only 15–20% smallest eigenvalue and corresponding eigenvectors are sufficient to secure the acceptable accuracy. Once the single frequency response is computed using eigenmode approach, the responses for subsequent frequencies can be obtained in negligible time. Experiment design results for validation of FDA2DMT are presented by considering two synthetic models from COMMEMI report, Brewitt-Taylor and Weaver (1976) model and a field data based model from Garhwal Himalaya.

  3. Application of modified Arnoldi algorithm to passive macromodeling of MEMS.

    Science.gov (United States)

    Wong, Woon Ket; Wang, Wei

    2009-02-01

    The demand for accurately simulating dynamical responses of complex MEMS and NEMS systems leads to intensive studies in reduced-order modeling methods. We apply a modified Block Arnoldi algorithm to significantly reduce the run time and usage of computer resource for such calculations, while preserving essential properties. The 2n x 2n matrix in the computation is replaced by a n x n matrix and the FLOP count is reduced from (56n(3) - 216n(2) + 22n) / 3 to (7n(3) - 54n(2) + 11n) / 3. The CPU run time for a resonator example of n = 39 is reduced from 0.091 second to 0.080 second. For a butterfly gyroscope example with a larger matrix size, n = 17361, the CPU time is reduced from 4343 seconds to 1528 seconds, achieving 65% improvement.

  4. Parallelizable restarted iterative methods for nonsymmetric linear systems. Part 1: Theory

    Energy Technology Data Exchange (ETDEWEB)

    Joubert, W.D.; Carey, G.F.

    1991-05-01

    Large sparse nonsymmetric problems of the form Au = b are frequently solved using restarted conjugate gradient-type algorithms such as the popular GCR and GMRES algorithms. In this study the authors define a new class of algorithms which generate the same iterates as the standard GMRES algorithm but require as little as half of the computational expense. This performance improvement is obtained by using short economical three-term recurrences to replace the long recurrence used by GMRES. The new algorithms are shown to have good numerical properties in typical cases, and the new algorithms may be easily modified to be as numerically safe as standard GMRES. Numerical experiments with these algorithms are given in Part 2, in which they demonstrate the improved performance of the new schemes on different computer architectures.

  5. Stable reduced-order models of generalized dynamical systems using coordinate-transformed Arnoldi algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Silveira, L.M.; Kamon, M.; Elfadel, I.; White, J. [Massachusetts Inst. of Technology, Cambridge, MA (United States)

    1996-12-31

    Model order reduction based on Krylov subspace iterative methods has recently emerged as a major tool for compressing the number of states in linear models used for simulating very large physical systems (VLSI circuits, electromagnetic interactions). There are currently two main methods for accomplishing such a compression: one is based on the nonsymmetric look-ahead Lanczos algorithm that gives a numerically stable procedure for finding Pade approximations, while the other is based on a less well characterized Arnoldi algorithm. In this paper, we show that for certain classes of generalized state-space systems, the reduced-order models produced by a coordinate-transformed Arnoldi algorithm inherit the stability of the original system. Complete Proofs of our results will be given in the final paper.

  6. A technique for accelerating the convergence of restarted GMRES

    Energy Technology Data Exchange (ETDEWEB)

    Baker, A H; Jessup, E R; Manteuffel, T

    2004-03-09

    We have observed that the residual vectors at the end of each restart cycle of restarted GMRES often alternate direction in a cyclic fashion, thereby slowing convergence. We present a new technique for accelerating the convergence of restarted GMRES by disrupting this alternating pattern. The new algorithm resembles a full conjugate gradient method with polynomial preconditioning, and its implementation requires minimal changes to the standard restarted GMRES algorithm.

  7. A technique for accelerating the convergence of restarted GMRES

    Energy Technology Data Exchange (ETDEWEB)

    Baker, A H; Jessup, E R; Manteuffel, T

    2004-03-09

    We have observed that the residual vectors at the end of each restart cycle of restarted GMRES often alternate direction in a cyclic fashion, thereby slowing convergence. We present a new technique for accelerating the convergence of restarted GMRES by disrupting this alternating pattern. The new algorithm resembles a full conjugate gradient method with polynomial preconditioning, and its implementation requires minimal changes to the standard restarted GMRES algorithm.

  8. First Passage under Restart

    Science.gov (United States)

    Pal, Arnab; Reuveni, Shlomi

    2017-01-01

    First passage under restart has recently emerged as a conceptual framework suitable for the description of a wide range of phenomena, but the endless variety of ways in which restart mechanisms and first passage processes mix and match hindered the identification of unifying principles and general truths. Hope that these exist came from a recently discovered universality displayed by processes under optimal, constant rate, restart—but extensions and generalizations proved challenging as they marry arbitrarily complex processes and restart mechanisms. To address this challenge, we develop a generic approach to first passage under restart. Key features of diffusion under restart—the ultimate poster boy for this wide and diverse class of problems—are then shown to be completely universal.

  9. Replication Restart in Bacteria.

    Science.gov (United States)

    Michel, Bénédicte; Sandler, Steven J

    2017-07-01

    In bacteria, replication forks assembled at a replication origin travel to the terminus, often a few megabases away. They may encounter obstacles that trigger replisome disassembly, rendering replication restart from abandoned forks crucial for cell viability. During the past 25 years, the genes that encode replication restart proteins have been identified and genetically characterized. In parallel, the enzymes were purified and analyzed in vitro, where they can catalyze replication initiation in a sequence-independent manner from fork-like DNA structures. This work also revealed a close link between replication and homologous recombination, as replication restart from recombination intermediates is an essential step of DNA double-strand break repair in bacteria and, conversely, arrested replication forks can be acted upon by recombination proteins and converted into various recombination substrates. In this review, we summarize this intense period of research that led to the characterization of the ubiquitous replication restart protein PriA and its partners, to the definition of several replication restart pathways in vivo, and to the description of tight links between replication and homologous recombination, responsible for the importance of replication restart in the maintenance of genome stability. Copyright © 2017 American Society for Microbiology.

  10. A simple strategy for varying the restart parameter in GMRES(m)

    Energy Technology Data Exchange (ETDEWEB)

    Baker, A H; Jessup, E R; Kolev, T V

    2007-10-02

    When solving a system of linear equations with the restarted GMRES method, a fixed restart parameter is typically chosen. We present numerical experiments that demonstrate the beneficial effects of changing the value of the restart parameter in each restart cycle on the total time to solution. We propose a simple strategy for varying the restart parameter and provide some heuristic explanations for its effectiveness based on analysis of the symmetric case.

  11. Restarted FOM Augmented with Ritz Vectors for Shifted Linear Systems

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The restarted FOM method presented by Simoncini [7] according to the natural collinearity of all residuals is an efficient method for solving shifted systems, which generates the same Krylov subspace when the shifts are handled simultaneously. However, restarting slows down the convergence. We present a practical method for solving the shifted systems by adding some Ritz vectors into the Krylov subspace to form an augmented Krylov subspace.Numerical experiments illustrate that the augmented FOM approach (restarted version) can converge more quickly than the restarted FOM method.

  12. Multi-order Arnoldi-based model order reduction of second-order time-delay systems

    Science.gov (United States)

    Xiao, Zhi-Hua; Jiang, Yao-Lin

    2016-09-01

    In this paper, we discuss the Krylov subspace-based model order reduction methods of second-order systems with time delays, and present two structure-preserving methods for model order reduction of these second-order systems, which avoid to convert the second-order systems into first-order ones. One method is based on a Krylov subspace by using the Taylor series expansion, the other method is based on the Laguerre series expansion. These two methods are used in the multi-order Arnoldi algorithm to construct the projection matrices. The resulting reduced models can not only preserve the structure of the original systems, but also can match a certain number of approximate moments or Laguerre expansion coefficients. The effectiveness of the proposed methods is demonstrated by two numerical examples.

  13. Hitting times for random walks with restarts

    CERN Document Server

    Janson, Svante

    2010-01-01

    The time it takes a random walker in a lattice to reach the origin from another vertex $x$, has infinite mean. If the walker can restart the walk at $x$ at will, then the minimum expected hitting time $T(x,0)$ (minimized over restarting strategies) is finite; it was called the ``grade'' of $x$ by Dumitriu, Tetali and Winkler. They showed that, in a more general setting, the grade (a variant of the ``Gittins index'') plays a crucial role in control problems involving several Markov chains. Here we establish several conjectures of Dumitriu et al on the asymptotics of the grade in Euclidean lattices. In particular, we show that in the planar square lattice, $T(x,0)$ is asymptotic to $2|x|^2\\log|x|$ as $|x| \\to \\infty$. The proof hinges on the local variance of the potential kernel $h$ being almost constant on the level sets of $h$. We also show how the same method yields precise second order asymptotics for hitting times of a random walk (without restarts) in a lattice disk.

  14. A FLEXIBLE PRECONDITIONED ARNOLDI METHOD FOR SHIFTED LINEAR SYSTEMS'

    Institute of Scientific and Technical Information of China (English)

    G.-D.Gu; X.-L.Zhou; Lei Lin

    2007-01-01

    We are interested in the numerical solution of the large nonsymmetric shifted linear system,(A+αI)x=b,for many different values of the shift α in a wide range.We apply the Saad's flexible preconditioning technique[14]to the solution of the shifted systems.Such flexible preconditioning with a few parameters could probably cover all the shifted systems with the shift in a wide range.Numerical experiments report the effectiveness of our approach on some problems.

  15. Optimality of Non-Restarting CUSUM charts

    OpenAIRE

    2012-01-01

    We show optimality, in a well-defined sense, using cumulative sum (CUSUM) charts for detecting changes in distributions. We consider a setting with multiple changes between two known distributions. This result advocates the use of non-restarting CUSUM charts with an upper boundary. Typically, after signalling, a CUSUM chart is restarted by setting it to some value below the threshold. A non-restarting CUSUM chart is not reset after signalling; thus is able to signal continuously. Imposing an ...

  16. LHC Report: Restart preparations continue

    CERN Multimedia

    Katy Foraz for the LHC team and Julia Trummer for the RP Group

    2012-01-01

    Maintenance and consolidation work has been progressing well in both the machine and the experiments in preparation for the March restart.   A sample material is attached to the LHC (the white bag taped to the green line), to measure the radiation doses. Additional work was required around Point 5 due to the discovery and repair of a problem with the RF fingers at the connection of two beam vacuum chambers in CMS. The repair has been completed successfully and the sector is now under vacuum. In order to avoid rushing the delicate final operations required for closing the detector, the restart of the machine has been postponed by one week, from 7 March to 14 March. In the machine, the first cool-down to 1.9 K has started in several sectors ,and the cool-down of the whole machine is still planned to be finished by 21 February. The time window between 22 February and 14 March will be dedicated to powering and cryogenic tests. Since 12 December, the Radiation Protection (RP) group has been deep...

  17. Taxonomy of the ant genus Proceratium Roger (Hymenoptera, Formicidae in the Afrotropical region with a revision of the P. arnoldi clade and description of four new species

    Directory of Open Access Journals (Sweden)

    Francisco Hita Garcia

    2014-10-01

    Full Text Available The taxonomy of the genus Proceratium Roger is updated for the Afrotropical region. We give an overview of the genus in the region, provide an illustrated identification key to the three clades (P. arnoldi, P. stictum and P. toschii clades and revise the P. arnoldi clade. Four new species from the P. arnoldi clade are described as new: P. sokoke sp. n. from Kenya, P. carri sp. n. from Mozambique, and P. nilo sp. n. and P. sali sp. n. from Tanzania. In order to integrate the new species into the existing taxonomic system we present an illustrated identification key to distinguish the seven Afrotropical species of the P. arnoldi clade. In addition, we provide accounts for all members of the P. arnoldi clade including detailed descriptions, diagnoses, taxonomic discussions, distribution data and high quality montage images.

  18. LHC Report: A tough restart

    CERN Multimedia

    Jan Uythoven for the LHC team

    2012-01-01

    The third LHC Technical Stop of five days took place in the week of September 17. Getting back to normal operation after a technical stop  can sometimes be difficult, with debugging, testing and requalification required on the systems that have seen interventions. Folding in a selection of other problems can make for a frustrating time.   The new injector magnet is transported to the LHC. Photo: TE/ABT group. The restart experienced over the last days was one of the tougher ones. Many problems occurred, both small and large, one after the other; in the end it took until Sunday afternoon, 9 days after the end of the technical stop, to have a physics fill in the machine that delivered an initial luminosity similar to those before the technical stop. Most problems encountered were, in fact, not related to the technical stop. The technical stop consisted of the usual maintenance and consolidation of the various systems, but two items stand out: the replacement of the mirrors an...

  19. Some comparison of restarted GMRES and QMR for linear and nonlinear problems

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, R. [Baylor Univ., Waco, TX (United States); Joubert, W. [Los Alamos National Lab., NM (United States)

    1994-12-31

    Comparisons are made between the following methods: QMR including its transpose-free version, restarted GMRES, and a modified restarted GMRES that uses approximate eigenvectors to improve convergence, For some problems, the modified GMRES is competitive with or better than QMR in terms of the number of matrix-vector products. Also, the GMRES methods can be much better when several similar systems of linear equations must be solved, as in the case of nonlinear problems and ODE problems.

  20. Incidence of pigmented skin tumors in a population of wild Montseny brook newt (Calotriton arnoldi).

    Science.gov (United States)

    Martínez-Silvestre, Albert; Amat, Fèlix; Bargalló, Ferran; Carranza, Salvador

    2011-04-01

    We report the presence of pigmented skin tumors in three populations of the endangered amphibian Montseny brook newt, Calotriton arnoldi, one of the European amphibian species with the smallest distribution range (40 km(2) in the Montseny Natural Park, Catalonia, Spain). Examination of one of the tumors by light microscopy was consistent with chromatophoroma and was most suggestive of a melanophoroma. Tumors were not found in juveniles. In adults, only two of three populations were affected. The proportions of males and females affected were not significantly different, but there was a positive correlation between body size and presence of tumors in both sexes. The etiology of chromatophoromas remains unknown but, in our study, they do not appear to have been caused by water quality or Ultraviolet B.

  1. Beleaguered LHC gears up for restart

    CERN Multimedia

    Cartwright, Jon

    2009-01-01

    "The Large Hadron Collider (LHC) is finally set to restart in mid-November following last year's accident. Initially it will collide protons at an energy of only 3.5 TeV per beam, and staff at Cern will have to wait until late next year before trying to run the collider at its maximum energy" (0.75 page)

  2. LHC Experiments: refinements for the restart

    CERN Multimedia

    2009-01-01

    As the LHC restart draws closer, the Bulletin will be taking a look at how the six LHC experiments are preparing and what they have been up to since last September. In this issue we start with a roundup of the past 10 months of activity at CMS and ATLAS, both technical work and outreach activities.

  3. Inner Random Restart Genetic Algorithm for Practical Delivery Schedule Optimization

    Science.gov (United States)

    Sakurai, Yoshitaka; Takada, Kouhei; Onoyama, Takashi; Tsukamoto, Natsuki; Tsuruta, Setsuo

    A delivery route optimization that improves the efficiency of real time delivery or a distribution network requires solving several tens to hundreds but less than 2 thousands cities Traveling Salesman Problems (TSP) within interactive response time (less than about 3 second), with expert-level accuracy (less than about 3% of error rate). Further, to make things more difficult, the optimization is subjects to special requirements or preferences of each various delivery sites, persons, or societies. To meet these requirements, an Inner Random Restart Genetic Algorithm (Irr-GA) is proposed and developed. This method combines meta-heuristics such as random restart and GA having different types of simple heuristics. Such simple heuristics are 2-opt and NI (Nearest Insertion) methods, each applied for gene operations. The proposed method is hierarchical structured, integrating meta-heuristics and heuristics both of which are multiple but simple. This method is elaborated so that field experts as well as field engineers can easily understand to make the solution or method easily customized and extended according to customers' needs or taste. Comparison based on the experimental results and consideration proved that the method meets the above requirements more than other methods judging from not only optimality but also simplicity, flexibility, and expandability in order for this method to be practically used.

  4. Failure Recovery via RESTART: Wallclock Models

    DEFF Research Database (Denmark)

    Asmussen, Søren; Rønn-Nielsen, Anders

    A task such as the execution of a computer program or the transfer of a file on a communications link may fail and then needs to be restarted. Let the ideal task time be a constant $\\ell$ and the actual task time $X$, a random variable. Tail asymptotics for $\\mathbb{P}(X>x)$ is given under three...... are presented for $X$ to be finite a.s. The results complement those of Asmussen, Fiorini, Lipsky, Rolski & Sheahan [Math. Oper. Res. 33, 932--944, 2008] who took $r(t)\\equiv 1$ and assumed the failure rate to be a function of the time elapsed since the last restart rather than wallclock time....

  5. Restart of the LHC in 2009

    CERN Multimedia

    Corinne Pralavorio

    The restart of the LHC during the summer 2009 has been confirmed today, the 5 December. An updated report on the incident which damaged sector 3-4 has just been published. It gives details on the damage caused by the incident and explains the ongoing repairs and the new systems being put into place to reinforce the safety of the machine. Click here to see the report.

  6. Waxy crude oil flow restart ability

    Energy Technology Data Exchange (ETDEWEB)

    Sierra, Andre Gaona; Varges, Priscilla Ribeiro; Mendes, Paulo Roberto de Souza [Dept. of Mechanical Engineering. Pontificia Universidade Catolica do Rio de Janeiro, RJ (Brazil)], e-mails: prvarges@puc-rio.br, pmendes@puc-rio.br; Ziglio, Claudio [PETROBRAS S.A, R.J., Rio de Janeiro, RJ (Brazil)], e-mail: ziglio@petrobras.com.br

    2010-07-01

    Under the hot reservoir conditions, waxy crudes behave like Newtonian fluids but once they experience very cold temperatures on the sea floor, the heavy paraffin's begin to precipitate from the solution impacting non- Newtonian flow behavior to the crude (Chang 2000, Lee 2009, Davidson 2004) and begin to deposit on the pipe wall leave blocked of pipeline. This gel cannot be broken with the original steady state flow operating pressure applied before gelation (Chang 1998). Restarting waxy crude oil flows in pipelines is a difficult issue because of the complex rheological behavior of the gelled oil. Indeed, below the WAT, the gelled oil exhibits viscoplastic, thixotropic, temperature-dependent, and compressible properties due to the interlocking gel-like structure formed by the crystallized paraffin compounds and the thermal shrinkage of the oil. The main objective of this work is to determine the minimal pressure to restart the flow, and the relationship between the fluid rheology , pipe geometry and the restart pressure of the flow. Experiments will be performed to investigate the displacement of carbopol aqueous solutions (viscoplastic fluid without thixotropic effects) by Newtonian oil flowing through a strait pipe to validate the experimental apparatus. Therefore, tests will be made with different fluids, like Laponite and waxy crude oils. (author)

  7. Keeping checkpoint/restart viable for exascale systems.

    Energy Technology Data Exchange (ETDEWEB)

    Riesen, Rolf E.; Bridges, Patrick G. (IBM Research, Ireland, Mulhuddart, Dublin); Stearley, Jon R.; Laros, James H., III; Oldfield, Ron A.; Arnold, Dorian (University of New Mexico, Albuquerque, NM); Pedretti, Kevin Thomas Tauke; Ferreira, Kurt Brian; Brightwell, Ronald Brian

    2011-09-01

    Next-generation exascale systems, those capable of performing a quintillion (10{sup 18}) operations per second, are expected to be delivered in the next 8-10 years. These systems, which will be 1,000 times faster than current systems, will be of unprecedented scale. As these systems continue to grow in size, faults will become increasingly common, even over the course of small calculations. Therefore, issues such as fault tolerance and reliability will limit application scalability. Current techniques to ensure progress across faults like checkpoint/restart, the dominant fault tolerance mechanism for the last 25 years, are increasingly problematic at the scales of future systems due to their excessive overheads. In this work, we evaluate a number of techniques to decrease the overhead of checkpoint/restart and keep this method viable for future exascale systems. More specifically, this work evaluates state-machine replication to dramatically increase the checkpoint interval (the time between successive checkpoint) and hash-based, probabilistic incremental checkpointing using graphics processing units to decrease the checkpoint commit time (the time to save one checkpoint). Using a combination of empirical analysis, modeling, and simulation, we study the costs and benefits of these approaches on a wide range of parameters. These results, which cover of number of high-performance computing capability workloads, different failure distributions, hardware mean time to failures, and I/O bandwidths, show the potential benefits of these techniques for meeting the reliability demands of future exascale platforms.

  8. Pervasive Restart In MOOSE-based Applications

    Energy Technology Data Exchange (ETDEWEB)

    Derek Gaston; Cody Permann; David Andrs; John Peterson; Andrew Slaughter; Jason Miller

    2014-01-01

    Multiphysics applications are inherently complicated. Solving for multiple, interacting physical phenomena involves the solution of multiple equations, and each equation has its own data dependencies. Feeding the correct data to these equations at exactly the right time requires extensive effort in software design. In an ideal world, multiphysics applications always run to completion and produce correct answers. Unfortunately, in reality, there can be many reasons why a simulation might fail: power outage, system failure, exceeding a runtime allotment on a supercomputer, failure of the solver to converge, etc. A failure after many hours spent computing can be a significant setback for a project. Therefore, the ability to “continue” a solve from the point of failure, rather than starting again from scratch, is an essential component of any high-quality simulation tool. This process of “continuation” is commonly termed “restart” in the computational community. While the concept of restarting an application sounds ideal, the aforementioned complexities and data dependencies present in multiphysics applications make its implementation decidedly non-trivial. A running multiphysics calculation accumulates an enormous amount of “state”: current time, solution history, material properties, status of mechanical contact, etc. This “state” data comes in many different forms, including scalar, tensor, vector, and arbitrary, application-specific data types. To be able to restart an application, you must be able to both store and retrieve this data, effectively recreating the state of the application before the failure. When utilizing the Multiphysics Object Oriented Simulation Environment (MOOSE) framework developed at Idaho National Laboratory, this state data is stored both internally within the framework itself (such as solution vectors and the current time) and within the applications that use the framework. In order to implement restart in MOOSE

  9. Promoting Recruitment using Information Management Efficiently (PRIME): study protocol for a stepped-wedge cluster randomised controlled trial within the REstart or STop Antithrombotics Randomised Trial (RESTART).

    Science.gov (United States)

    Maxwell, Amy E; Dennis, Martin; Rudd, Anthony; Weir, Christopher J; Parker, Richard A; Al-Shahi Salman, Rustam

    2017-03-01

    Research into methods to boost recruitment has been identified as the highest priority for randomised controlled trial (RCT) methodological research in the United Kingdom. Slow recruitment delays the delivery of research and inflates costs. Using electronic patient records has been shown to boost recruitment to ongoing RCTs in primary care by identifying potentially eligible participants, but this approach remains relatively unexplored in secondary care, and for stroke in particular. The REstart or STop Antithrombotics Randomised Trial (RESTART; ISRCTN71907627) is an ongoing RCT of secondary prevention after stroke due to intracerebral haemorrhage. Promoting Recruitment using Information Management Efficiently (PRIME) is a stepped-wedge cluster randomised trial of a complex intervention to help RESTART sites increase their recruitment and attain their own target numbers of participants. Seventy-two hospital sites that were located in England, Wales or Scotland and were active in RESTART in June 2015 opted into PRIME. Sites were randomly allocated (using a computer-generated block randomisation algorithm, stratified by hospital location in Scotland vs. England/Wales) to one of 12 months in which the intervention would be delivered. All sites began in the control state. The intervention was delivered by a recruitment co-ordinator via a teleconference with each site. The intervention involved discussing recruitment strategies, providing software for each site to extract from their own stroke audit data lists of patients who were potentially eligible for RESTART, and a second teleconference to review progress 6 months later. The recruitment co-ordinator was blinded to the timing of the intervention until 2 months before it was due at a site. Staff at RESTART sites were blinded to the nature and timing of the intervention. The primary outcome is the total number of patients randomised into RESTART per month per site and will be analysed in a negative binomial

  10. LHC Report: Rocky re-start

    CERN Multimedia

    Barbara Holzer for the LHC Team

    2012-01-01

    A rocky re-start with beam followed a successful machine development period and the first technical stop of 2012. Today, Friday 11 May, the machine began running again with 1380 bunches.   A short, two-day machine development period was successfully completed on 21-22 April. It focused on topics relevant for the 2012 physics beam operation. This was then followed by a five-day technical stop, the first of the year. The technical stop finished on time on Friday 26 April. The re-start with beam was somewhat tortuous and hampered by an unlucky succession of technical faults leading to extended periods of downtime. The planned intensity increase was put on hold for three days with the machine operating with 1092 bunches and a moderate bunch intensity of 1.3x1011 protons. This delivered a reasonable peak luminosity of 3.6x1033 cm-2s-1 to ATLAS and CMS. Higher than usual beam losses were observed in the ramp and squeeze, and time was required to investigate the causes and to implement mitigati...

  11. ALICE & LHCb: refinements for the restart

    CERN Multimedia

    2009-01-01

    Following the previous issue, the Bulletin continues its series to find out what the six LHC experiments have been up to since last September, and how they are preparing for the restart. Previously we looked at CMS and ATLAS; this issue we will round up the past 10 months of activity at ALICE and LHCb. LHCb The cavern of the LHCb experiment. This year has given LHCb the chance to install the 5th and final plane of muon chambers, which will improve the triggering at nominal luminosity. This is the final piece of the experiment to be installed. "Now the detector looks exactly as it does in the technical design report," confirms Andrei Golutvin, LHCb Spokesperson. "We also took advantage of this shutdown to make several improvements. For example, we modified the high voltage system of the electromagnetic calorimeter to reduce noise further to a negligible level. We also took some measures to improve ...

  12. Global Convergence of a New Restarting Conjugate Gradient Method for Nonlinear Optimizations%求解无约束非线性规划问题的一个新的重开始共轭梯度算法的收敛性

    Institute of Scientific and Technical Information of China (English)

    孙清滢

    2003-01-01

    Conjugate gradient optimization algorithms depend on the search directions with differentchoices for the parameters in the search directions. In this note, by combining the nice numerical per-formance of PR and HS methods with the global convergence property of the class of conjugate gradientmethods presented by HU and STOREY(1991), a class of new restarting conjugate gradient methodsis presented. Global convergences of the new method with two kinds of common line searches, areproved. Firstly, it is shown that, using reverse modulus of continuity function and forcing function,the new method for solving unconstrained optimization can work for a continously differentiable functionwith Curry-Altman's step size rule and a bounded level set. Secondly, by using comparing technique,some general convergence propecties of the new method with other kind of step size rule are established.Numerical experiments show that the new method is efficient by comparing with FR conjugate gradientmethod.

  13. Initialization and Restart in Stochastic Local Search: Computing a Most Probable Explanation in Bayesian Networks

    Science.gov (United States)

    Mengshoel, Ole J.; Wilkins, David C.; Roth, Dan

    2010-01-01

    For hard computational problems, stochastic local search has proven to be a competitive approach to finding optimal or approximately optimal problem solutions. Two key research questions for stochastic local search algorithms are: Which algorithms are effective for initialization? When should the search process be restarted? In the present work we investigate these research questions in the context of approximate computation of most probable explanations (MPEs) in Bayesian networks (BNs). We introduce a novel approach, based on the Viterbi algorithm, to explanation initialization in BNs. While the Viterbi algorithm works on sequences and trees, our approach works on BNs with arbitrary topologies. We also give a novel formalization of stochastic local search, with focus on initialization and restart, using probability theory and mixture models. Experimentally, we apply our methods to the problem of MPE computation, using a stochastic local search algorithm known as Stochastic Greedy Search. By carefully optimizing both initialization and restart, we reduce the MPE search time for application BNs by several orders of magnitude compared to using uniform at random initialization without restart. On several BNs from applications, the performance of Stochastic Greedy Search is competitive with clique tree clustering, a state-of-the-art exact algorithm used for MPE computation in BNs.

  14. FINAL REPORT UFP RESTART AND SPARGER TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero, H; Michael Restivo, M

    2004-11-30

    Following a Design Basis Event (DBE), potential plugging of the PJM systems is highly probable after air compressors and/or electric power become unavailable for up to 100 hrs. Under such conditions, the rheologically bounding yield stress of the pretreated sludge simulant could reach 300-625 Pa. (Defined in WTP-RPP-100, Rev. 0, Sec. 6.1. [1] and WTP-RPP-98, Rev. 0, Secs. 5.1 and 5.2 [2].) The tests covered under this report are conservative since this range of bounding yield stress is based on the settled solids component in the tank. Also, note that CCN 065607 states that the design basis is 70 Pa for 'gelled material' over the entire tank. Three issues must be addressed by these tests: (1) Determine the required pressure and air flow to overcome the plugged sparger tube resistance following a DBE event. (2) Can the UFP PJMs be restarted with or without assistance from air spargers? (3) Show that solids can be mixed by air spargers following a DBE to allow generated hydrogen gas to rise and be vented to the vessel head space. This is to limit hydrogen concentrations below LFL level. In the first test, a full-scale sparger was simulated by a 2-inch dia. Schedule 160 pipe, installed in an 18-inch diameter plastic tank, 37-foot high (full scale height), 6-inch from the bottom. The bottom 5-ft. lower section was clear to facilitate visual observations. Two simulants were used: a 120 Pa Laponite solution and a 30 Pa/30 cP kaolin:bentonite clay mixture, which filled the tank to the 32-foot level. The first test with 120 Pa Laponite demonstrated breakthrough at an air pressure of 14.6 psig. The second test with the clay simulant resulted in breakthrough at 16.7 psig. Given the specific gravities of these simulants, the breakthrough pressures are very close to the hydrostatic pressures corresponding to the simulant elevations inside the sparger. The CRV test stand at the Engineering Development Laboratory, SRNL, was used to simulate the UFP at 1/4-scale, where

  15. Integrative Phylogeography of Calotriton Newts (Amphibia, Salamandridae), with Special Remarks on the Conservation of the Endangered Montseny Brook Newt (Calotriton arnoldi)

    Science.gov (United States)

    Valbuena-Ureña, Emilio; Amat, Fèlix; Carranza, Salvador

    2013-01-01

    The genus Calotriton includes two species of newts highly adapted to live in cold and fast-flowing mountain springs. The Pyrenean brook newt (Calotriton asper), restricted to the Pyrenean region, and the Montseny brook newt (Calotriton arnoldi), endemic to the Montseny massif and one of the most endangered amphibian species in Europe. In the present manuscript, we use an integrative approach including species distribution modeling (SDM), molecular analyses of mitochondrial and nuclear DNA sequence data and morphology to unravel the historical processes that have contributed to shaping the biogeography and genetic structure of the genus Calotriton, with special emphasis on the conservation of C. arnoldi. The results of the molecular analyses confirm that, despite having originated recently, being ecologically similar and geographically very close, there is no signal of hybridization between C. asper and C. arnoldi. SDM results suggest that tough environmental conditions on mountains tops during glacial periods, together with subsequent warmer periods could have prevented the contact between the two species. Within the critically endangered C. arnoldi, a high genetic structure is revealed despite its extremely small distribution range compared to C. asper. Haplotype networks, AMOVA and SAMOVA analyses suggest that two distinct groups of populations can be clearly differentiated with absence of gene flow. This is in concordance with morphological differentiation and correlates with its geographical distribution, as the two groups are situated on the eastern and western sides of a river valley that acts as a barrier. The genetic and morphological results are highly important for the ongoing conservation program of C. arnoldi and strongly justify the management of this species into at least two independent evolutionary significant units (eastern and western sectors) to guarantee the long-term population viability. PMID:23750201

  16. Integrative phylogeography of Calotriton newts (Amphibia, Salamandridae, with special remarks on the conservation of the endangered Montseny brook newt (Calotriton arnoldi.

    Directory of Open Access Journals (Sweden)

    Emilio Valbuena-Ureña

    Full Text Available The genus Calotriton includes two species of newts highly adapted to live in cold and fast-flowing mountain springs. The Pyrenean brook newt (Calotriton asper, restricted to the Pyrenean region, and the Montseny brook newt (Calotriton arnoldi, endemic to the Montseny massif and one of the most endangered amphibian species in Europe. In the present manuscript, we use an integrative approach including species distribution modeling (SDM, molecular analyses of mitochondrial and nuclear DNA sequence data and morphology to unravel the historical processes that have contributed to shaping the biogeography and genetic structure of the genus Calotriton, with special emphasis on the conservation of C. arnoldi. The results of the molecular analyses confirm that, despite having originated recently, being ecologically similar and geographically very close, there is no signal of hybridization between C. asper and C. arnoldi. SDM results suggest that tough environmental conditions on mountains tops during glacial periods, together with subsequent warmer periods could have prevented the contact between the two species. Within the critically endangered C. arnoldi, a high genetic structure is revealed despite its extremely small distribution range compared to C. asper. Haplotype networks, AMOVA and SAMOVA analyses suggest that two distinct groups of populations can be clearly differentiated with absence of gene flow. This is in concordance with morphological differentiation and correlates with its geographical distribution, as the two groups are situated on the eastern and western sides of a river valley that acts as a barrier. The genetic and morphological results are highly important for the ongoing conservation program of C. arnoldi and strongly justify the management of this species into at least two independent evolutionary significant units (eastern and western sectors to guarantee the long-term population viability.

  17. Integrative phylogeography of Calotriton newts (Amphibia, Salamandridae), with special remarks on the conservation of the endangered Montseny brook newt (Calotriton arnoldi).

    Science.gov (United States)

    Valbuena-Ureña, Emilio; Amat, Fèlix; Carranza, Salvador

    2013-01-01

    The genus Calotriton includes two species of newts highly adapted to live in cold and fast-flowing mountain springs. The Pyrenean brook newt (Calotriton asper), restricted to the Pyrenean region, and the Montseny brook newt (Calotriton arnoldi), endemic to the Montseny massif and one of the most endangered amphibian species in Europe. In the present manuscript, we use an integrative approach including species distribution modeling (SDM), molecular analyses of mitochondrial and nuclear DNA sequence data and morphology to unravel the historical processes that have contributed to shaping the biogeography and genetic structure of the genus Calotriton, with special emphasis on the conservation of C. arnoldi. The results of the molecular analyses confirm that, despite having originated recently, being ecologically similar and geographically very close, there is no signal of hybridization between C. asper and C. arnoldi. SDM results suggest that tough environmental conditions on mountains tops during glacial periods, together with subsequent warmer periods could have prevented the contact between the two species. Within the critically endangered C. arnoldi, a high genetic structure is revealed despite its extremely small distribution range compared to C. asper. Haplotype networks, AMOVA and SAMOVA analyses suggest that two distinct groups of populations can be clearly differentiated with absence of gene flow. This is in concordance with morphological differentiation and correlates with its geographical distribution, as the two groups are situated on the eastern and western sides of a river valley that acts as a barrier. The genetic and morphological results are highly important for the ongoing conservation program of C. arnoldi and strongly justify the management of this species into at least two independent evolutionary significant units (eastern and western sectors) to guarantee the long-term population viability.

  18. Preparing for the re-start

    CERN Multimedia

    2009-01-01

    The end of a Council week is a good opportunity to bring you up to date with the status of the LHC, and I’m pleased to say that we had a good deal of positive news to report to the delegations today. The bottom line is that we remain on course to restart the LHC safely this year, albeit currently about 2-3 weeks later than we’d hoped at Chamonix. This Council week has seen many important developments for our future. I am particularly pleased that Council approved the Medium Term Plan and budget for 2010 as presented by the management. This is a strong vote of confidence in all of you. The President of Council is reporting on Council business in this issue of the Bulletin, so I will focus on the status of the LHC. A tremendous amount of work has been done to understand fully the splices in the LHC’s superconducting cable and copper stabilizers. One of these splices was the root cause of the incident last September that brought ...

  19. TOTEM and LHCf: refinements for the restart

    CERN Multimedia

    2009-01-01

    Following the previous two issues, the Bulletin continues its series to find out what the six LHC experiments have been up to since last September, and how they are preparing for the restart. We covered CMS, ATLAS, LHCb and ALICE in previous issues. In this issue we will round up the past 10 months of activity at TOTEM and LHCf. Roman Pots of the TOTEM experiment.TOTEM The past 10 months at TOTEM have been amongst the busiest since the project’s inception. The delay in the LHC startup has certainly had a silver lining for the TOTEM collaboration - not only has it given them a much-needed opportunity to test and install many crucial new detector parts, but also the lower energy range that the LHC will initially operate at in 2009 is perfect for TOTEM physics. "In fact, the LHC almost seems to be following the schedule of TOTEM!" jokes Karsten Eggert, TOTEM spokesperson. TOTEM is made up of three different detectors spread out...

  20. Press Conference: LHC Restart, Season 2

    CERN Document Server

    CERN. Geneva

    2015-01-01

    PRESS BRIEFING ON THE LARGE HADRON COLLIDER (LHC) RE-START, SEASON 2 AT CERN, GLOBE OF SCIENCE AND INNOVATION Where :   http://cern.ch/directions   at the Globe of Science and Innovation When : Thursday, 12 March from 2.30 to 3.30pm - Open seating as from 2.15pm Speakers : CERN’s Director General, Rolf Heuer and Director of Accelerators, Frédérick Bordry, and representatives of the LHC experiments Webcast : https://webcast.web.cern.ch/webcast/ Dear Journalists, CERN is pleased to invite you to the above press briefing which will take place on Thursday 12 March, in the Globe of Science and Innovation, 1st floor, from 2.30 to 3.30pm. The Large Hadron Collider (LHC) is ready to start up for its second three-year run. The 27km LHC is the largest and most powerful particle accelerator in the world operating at a temperature of -217 degrees Centigrade and powered to a current of 11,000 amps. Run 2 of the LHC follows a two-year technical s...

  1. LHC Availability 2016: Restart to Technical Stop 1

    CERN Document Server

    Todd, Benjamin; Apollonio, Andrea; CERN. Geneva. ATS Department

    2016-01-01

    This document summarises the LHC machine availability for the period of Restart to Technical Stop 1 (TS1) in 2016. This period was dedicated to restart of the LHC for proton physics with a bunch spacing of 25ns. This note has been produced and ratified by the LHC Availability Working Group which has complied fault information for the period in question using the Accelerator Fault Tracker.

  2. Digital-computer normal shock position and restart control of a Mach 2.5 axisymmetric mixed-compression inlet

    Science.gov (United States)

    Neiner, G. H.; Cole, G. L.; Arpasi, D. J.

    1972-01-01

    Digital computer control of a mixed-compression inlet is discussed. The inlet was terminated with a choked orifice at the compressor face station to dynamically simulate a turbojet engine. Inlet diffuser exit airflow disturbances were used. A digital version of a previously tested analog control system was used for both normal shock and restart control. Digital computer algorithms were derived using z-transform and finite difference methods. Using a sample rate of 1000 samples per second, the digital normal shock and restart controls essentially duplicated the inlet analog computer control results. At a sample rate of 100 samples per second, the control system performed adequately but was less stable.

  3. Restarting TMI unit one: social and psychological impacts

    Energy Technology Data Exchange (ETDEWEB)

    Sorensen, J.; Soderstrom, J.; Bolin, R.; Copenhaver, E.; Carnes, S.

    1983-12-01

    A technical background is provided for preparing an environmental assessment of the social and psychological impacts of restarting the undamaged reactor at Three Mile Island (TMI). Its purpose is to define the factors that may cause impacts, to define what those impacts might be, and to make a preliminary assessment of how impacts could be mitigated. It does not attempt to predict or project the magnitude of impacts. Four major research activities were undertaken: a literature review, focus-group discussions, community profiling, and community surveys. As much as possible, impacts of the accident at Unit 2 were differentiated from the possible impacts of restarting Unit 1. It is concluded that restart will generate social conflict in the TMI vicinity which could lead to adverse effects. Furthermore, between 30 and 50 percent of the population possess characteristics which are associated with vulnerability to experiencing negative impacts. Adverse effects, however, can be reduced with a community-based mitigation strategy.

  4. Economic evaluation of strategies for restarting anticoagulation therapy after a first event of unprovoked venous thromboembolism.

    Science.gov (United States)

    Monahan, M; Ensor, J; Moore, D; Fitzmaurice, D; Jowett, S

    2017-08-01

    Essentials Correct duration of treatment after a first unprovoked venous thromboembolism (VTE) is unknown. We assessed when restarting anticoagulation was worthwhile based on patient risk of recurrent VTE. When the risk over a one-year period is 17.5%, restarting is cost-effective. However, sensitivity analyses indicate large uncertainty in the estimates. Background Following at least 3 months of anticoagulation therapy after a first unprovoked venous thromboembolism (VTE), there is uncertainty about the duration of therapy. Further anticoagulation therapy reduces the risk of having a potentially fatal recurrent VTE but at the expense of a higher risk of bleeding, which can also be fatal. Objective An economic evaluation sought to estimate the long-term cost-effectiveness of using a decision rule for restarting anticoagulation therapy vs. no extension of therapy in patients based on their risk of a further unprovoked VTE. Methods A Markov patient-level simulation model was developed, which adopted a lifetime time horizon with monthly time cycles and was from a UK National Health Service (NHS)/Personal Social Services (PSS) perspective. Results Base-case model results suggest that treating patients with a predicted 1 year VTE risk of 17.5% or higher may be cost-effective if decision makers are willing to pay up to £20 000 per quality adjusted life year (QALY) gained. However, probabilistic sensitivity analysis shows that the model was highly sensitive to overall parameter uncertainty and caution is warranted in selecting the optimal decision rule on cost-effectiveness grounds. Univariate sensitivity analyses indicate variables such as anticoagulation therapy disutility and mortality risks were very influential in driving model results. Conclusion This represents the first economic model to consider the use of a decision rule for restarting therapy for unprovoked VTE patients. Better data are required to predict long-term bleeding risks during therapy in this

  5. Restarting Automata with Auxiliary Symbols and Small Lookahead

    DEFF Research Database (Denmark)

    Schluter, Natalie Elaine

    2012-01-01

    We present a study on lookahead hierarchies for restarting automata with auxiliary symbols and small lookahead. In particular, we show that there are just two different classes of languages recognised by RRWW automata, through the restriction of lookahead size. We also show that the respective...

  6. 40 CFR 86.236-94 - Engine starting and restarting.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Engine starting and restarting. 86.236-94 Section 86.236-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.236-94 Engine starting...

  7. User Process Checkpoint/Restart. Revision 1.1.

    Science.gov (United States)

    2007-11-02

    This document describes the design of the Tera user process checkpoint facility. Checkpoint is a means for saving the state of an executing process...or group of processes and restarting them later on demand. The motivation for providing checkpoint on the Tera is to allow long running computationally

  8. Restart plan for the prototype vertical denitration calciner

    Energy Technology Data Exchange (ETDEWEB)

    SUTTER, C.S.

    1999-09-01

    Testing activities on the Prototype Vertical Denitration Calciner at PFP were suspended in January 1997 due to the hold on fissile material handling in the facility. The Restart Plan will govern the transition of the test program from the completion of the activity based startup review; through equipment checkout and surrogate material runs; to resumption of the testing program and transition to unrestricted testing.

  9. LHC Availability 2017: Restart to Technical Stop 1

    CERN Document Server

    Todd, Benjamin; Apollonio, Andrea

    2017-01-01

    This document summarises the LHC machine availability for the period of Restart to Technical Stop 1 (TS1) in 2017. This period consisted of recommissioning the LHC following the Extended year End Technical Stop (EYETS 2016-17), and proton physics with a bunch spacing of 25ns. This note has been produced and ratified by the Availability Working Group which has complied fault information for the period in question using the Accelerator Fault Tracker.

  10. Management of Invasive Fungal Infections in Pediatric Acute Leukemia and the Appropriate Time for Restarting Chemotherapy

    Directory of Open Access Journals (Sweden)

    Özlem Tüfekçi

    2015-12-01

    Full Text Available INTRODUCTION: Rapid and effective treatment of invasive fungal infection (IFI in patients with leukemia is important for survival. In this study, we aimed to describe variations regarding clinical features, treatment modalities, time of restarting chemotherapy, and outcome in children with IFI and acute leukemia (AL. METHODS: The charts of all pediatric AL patients in our clinic between the years of 2001 and 2013 were retrospectively reviewed. All patients received prophylactic fluconazole during the chemotherapy period. RESULTS: IFI was identified in 25 (14% of 174 AL patients. Most of them were in the consolidation phase of chemotherapy and the patients had severe neutropenia. The median time between leukemia diagnosis and definition of IFI was 122 days. Twenty-four patients had pulmonary IFI. The most frequent finding on computed tomography was typical parenchymal nodules. The episodes were defined as proven in 4 (16% patients, probable in 7 (28% patients, and possible in 14 (56% patients. The median time for discontinuation of chemotherapy was 27 days. IFI was treated successfully in all patients with voriconazole, amphotericin B, caspofungin, or posaconazole alone or in combination. Chemotherapy was restarted in 50% of the patients safely within 4 weeks and none of those patients experienced reactivation of IFI. All of them were given secondary prophylaxis. The median time for antifungal treatment and for secondary prophylaxis was 26 and 90 days, respectively. None of the patients died due to IFI. DISCUSSION AND CONCLUSION: Our data show that rapid and effective antifungal therapy with rational treatment modalities may decrease the incidence of death and that restarting chemotherapy within several weeks may be safe in children with AL and IFI.

  11. RELAP5-3D Restart and Backup Verification Testing

    Energy Technology Data Exchange (ETDEWEB)

    Dr. George L Mesina

    2013-09-01

    Existing testing methodology for RELAP5-3D employs a set of test cases collected over two decades to test a variety of code features and run on a Linux or Windows platform. However, this set has numerous deficiencies in terms of code coverage, detail of comparison, running time, and testing fidelity of RELAP5-3D restart and backup capabilities. The test suite covers less than three quarters of the lines of code in the relap directory and just over half those in the environmental library. Even in terms of code features, many are not covered. Moreover, the test set runs many problems long past the point necessary to test the relevant features. It requires standard problems to run to completion. This is unnecessary for features can be tested in a short-running problem. For example, many trips and controls can be tested in the first few time steps, as can a number of fluid flow options. The testing system is also inaccurate. For the past decade, the diffem script has been the primary tool for checking that printouts from two different RELAP5-3D executables agree. This tool compares two output files to verify that all characters are the same except for those relating to date, time and a few other excluded items. The variable values printed on the output file are accurate to no more than eight decimal places. Therefore, calculations with errors in decimal places beyond those printed remain undetected. Finally, fidelity of restart is not tested except in the PVM sub-suite and backup is not specifically tested at all. When a restart is made from any midway point of the base-case transient, the restart must produce the same values. When a backup condition occurs, the code repeats advancements with the same time step. A perfect backup can be tested by forcing RELAP5 to perform a backup by falsely setting a backup condition flag at a user-specified-time. Comparison of the calculations of that run and those produced by the same input w/o the spurious condition should be

  12. RESTART simulation of non-Markov consecutive-k-out-of-n: F repairable systems

    Energy Technology Data Exchange (ETDEWEB)

    Villen-Altamirano, Jose, E-mail: jvillen@eui.upm.e [Departamento de Matematica Aplicada (E.U. Informatica), Universidad Politecnica de Madrid, Calle Arboleda s/n, 28031 Madrid (Spain)

    2010-03-15

    The reliability of consecutive-k-out-of-n: F repairable systems and (k-1)-step Markov dependence is studied. The model analyzed in this paper is more general than those of previous studies given that repair time and component lifetimes are random variables that follow a general distribution. The system has one repair service which adopts a priority repair rule based on system failure risk. Since crude simulation has proved to be inefficient for highly dependable systems, the RESTART method was used for the estimation of steady-state unavailability, MTBF and unreliability. Probabilities up to the order of 10{sup -16} have been accurately estimated with little computational effort. In this method, a number of simulation retrials are performed when the process enters regions of the state space where the chance of occurrence of a rare event (e.g., a system failure) is higher. The main difficulty for the application of this method is to find a suitable function, called the importance function, to define the regions. Given the simplicity involved in changing some model assumptions with RESTART, the importance function used in this paper could be useful for dependability estimation of many systems.

  13. Reinsurance Market in Russia Requires a Restart

    Directory of Open Access Journals (Sweden)

    I. S. Voronin

    2017-01-01

    Full Text Available Purpose: main objective of this article is to analyze dynamics and structure of the reinsurance market in Russia. Market research is conducted to understand the main trends in Russian reinsurance during period of economic sanctions. As these sanctions, affect incoming and outgoing reinsurance, as well as the development of the industry in the whole country. To achieve this goal, the article needs to address the following objectives: conduct a comparative analysis of the dynamics of the reinsurance market; to identify the current structure of the reinsurance market in Russia; to evaluate the influence of the Russian national reinsurance company in the insurance market of the Russian Federation. Methods: this article is based on the Central Bank of Russia consolidated data on the insurance market. Results: in the period imposed against our country economic sanctions by Western countries, the topic of import substitution is relevant not only in the productive sectors of the economy and the financial markets. In particular, in the present period it is necessary to obtain additional capacity with the market of international capital loans and improve the domestic investment climate in the country. Current international practice shows that the development of any financial industry would be impossible without effective sharing of different kinds of risks and their maximum leveling. Conclusions and Relevance: analysis conducted in the article allows to identify current trends in the insurance market in Russia from both internal and external players perspectives. The data demonstrates the main problem areas of the reinsurance community in Russia and ways of solving them. In addition, the article makes predictions about the development of the reinsurance market in Russia with the imposition of a new player – the national reinsurance company. 

  14. Investigation of Loop Heat Pipe Survival and Restart After Extreme Cold Environment Exposure

    Science.gov (United States)

    Golliher, Eric; Ku, Jentung; Licari, Anthony; Sanzi, James

    2010-01-01

    NASA plans human exploration near the South Pole of the Moon, and other locations where the environment is extremely cold. This paper reports on the heat transfer performance of a loop heat pipe (LHP) exposed to extreme cold under the simulated reduced gravitational environment of the Moon. A common method of spacecraft thermal control is to use a LHP with ammonia working fluid. Typically, a small amount of heat is provided either by electrical heaters or by environmental design, such that the LHP condenser temperature never drops below the freezing point of ammonia. The concern is that a liquid-filled, frozen condenser would not restart, or that a thawing condenser would damage the tubing due to the expansion of ammonia upon thawing. This paper reports the results of an experimental investigation of a novel approach to avoid these problems. The LHP compensation chamber (CC) is conditioned such that all the ammonia liquid is removed from the condenser and the LHP is nonoperating. The condenser temperature is then reduced to below that of the ammonia freezing point. The LHP is then successfully restarted.

  15. Data assimilation for unsaturated flow models with restart adaptive probabilistic collocation based Kalman filter

    Energy Technology Data Exchange (ETDEWEB)

    Man, Jun; Li, Weixuan; Zeng, Lingzao; Wu, Laosheng

    2016-06-01

    The ensemble Kalman filter (EnKF) has gained popularity in hydrological data assimilation problems. As a Monte Carlo based method, a relatively large ensemble size is usually required to guarantee the accuracy. As an alternative approach, the probabilistic collocation based Kalman filter (PCKF) employs the polynomial chaos to approximate the original system. In this way, the sampling error can be reduced. However, PCKF suffers from the so-called "curse of dimensionality". When the system nonlinearity is strong and number of parameters is large, PCKF could be even more computationally expensive than EnKF. Motivated by most recent developments in uncertainty quantification, we propose a restart adaptive probabilistic collocation based Kalman filter (RAPCKF) for data assimilation in unsaturated flow problems. During the implementation of RAPCKF, the important parameters are identified and active PCE basis functions are adaptively selected. The "restart" technology is used to eliminate the inconsistency between model parameters and states. The performance of RAPCKF is tested with numerical cases of unsaturated flow models. It is shown that RAPCKF is more efficient than EnKF with the same computational cost. Compared with the traditional PCKF, the RAPCKF is more applicable in strongly nonlinear and high dimensional problems.

  16. Restart-Based Genetic Algorithm for the Quadratic Assignment Problem

    Science.gov (United States)

    Misevicius, Alfonsas

    The power of genetic algorithms (GAs) has been demonstrated for various domains of the computer science, including combinatorial optimization. In this paper, we propose a new conceptual modification of the genetic algorithm entitled a "restart-based genetic algorithm" (RGA). An effective implementation of RGA for a well-known combinatorial optimization problem, the quadratic assignment problem (QAP), is discussed. The results obtained from the computational experiments on the QAP instances from the publicly available library QAPLIB show excellent performance of RGA. This is especially true for the real-life like QAPs.

  17. Berkeley lab checkpoint/restart (BLCR) for Linux clusters

    Science.gov (United States)

    Hargrove, Paul H.; Duell, Jason C.

    2006-09-01

    This article describes the motivation, design and implementation of Berkeley Lab Checkpoint/Restart (BLCR), a system-level checkpoint/restart implementation for Linux clusters that targets the space of typical High Performance Computing applications, including MPI. Application-level solutions, including both checkpointing and fault-tolerant algorithms, are recognized as more time and space efficient than system-level checkpoints, which cannot make use of any application-specific knowledge. However, system-level checkpointing allows for preemption, making it suitable for responding to ''fault precursors'' (for instance, elevated error rates from ECC memory or network CRCs, or elevated temperature from sensors). Preemption can also increase the efficiency of batch scheduling; for instance reducing idle cycles (by allowing for shutdown without any queue draining period or reallocation of resources to eliminate idle nodes when better fitting jobs are queued), and reducing the average queued time (by limiting large jobs to running during off-peak hours, without the need to limit the length of such jobs). Each of these potential uses makes BLCR a valuable tool for efficient resource management in Linux clusters.

  18. APPLICATION OF RESTART COVARIANCE MATRIX ADAPTATION EVOLUTION STRATEGY (RCMA-ES TO GENERATION EXPANSION PLANNING PROBLEM

    Directory of Open Access Journals (Sweden)

    K. Karthikeyan

    2012-10-01

    Full Text Available This paper describes the application of an evolutionary algorithm, Restart Covariance Matrix Adaptation Evolution Strategy (RCMA-ES to the Generation Expansion Planning (GEP problem. RCMA-ES is a class of continuous Evolutionary Algorithm (EA derived from the concept of self-adaptation in evolution strategies, which adapts the covariance matrix of a multivariate normal search distribution. The original GEP problem is modified by incorporating Virtual Mapping Procedure (VMP. The GEP problem of a synthetic test systems for 6-year, 14-year and 24-year planning horizons having five types of candidate units is considered. Two different constraint-handling methods are incorporated and impact of each method has been compared. In addition, comparison and validation has also made with dynamic programming method.

  19. Restart of K-Reactor, Savannah River Site: Safety evaluation report

    Energy Technology Data Exchange (ETDEWEB)

    1991-04-01

    This Safety Evaluation Report (SER) focuses on those issues required to support the restart of the K-Reactor at the Savannah River Plant. This SER provides the safety criteria for restart and documents the results of the staff reviews of the DOE and operating contractor activities to meet these criteria. To develop the restart criteria for the issues discussed in this SER, the Savannah River Restart Office and Savannah River Special Projects Office staffs relied, when possible, on commercial industry codes and standards and on NRC requirements and guidelines for the commercial nuclear industry. However, because of the age and uniqueness of the Savannah River reactors, criteria for the commercial plants were not always applicable. In these cases, alternate criteria were developed. The restart criteria applicable to each of the issues are identified in the safety evaluations for each issue. The restart criteria identified in this report are intended to apply only to restart of the Savannah River reactors. Following the development of the acceptance criteria, the DOE staff and their support contractors evaluated the results of the DOE and operating contractor (WSRC) activities to meet these criteria. The results of those evaluations are documented in this report. Deviations or failures to meet the requirements are either justified in the report or carried as open or confirmatory items to be completed and evaluated in supplements to this report before restart. 62 refs., 1 fig.

  20. Getting off to a good start? Genetic evaluation of the ex situ conservation project of the Critically Endangered Montseny brook newt (Calotriton arnoldi).

    Science.gov (United States)

    Valbuena-Ureña, Emilio; Soler-Membrives, Anna; Steinfartz, Sebastian; Alonso, Mònica; Carbonell, Francesc; Larios-Martín, Raquel; Obon, Elena; Carranza, Salvador

    2017-01-01

    Ex situ management strategies play an important role in the conservation of threatened species when the wild survival of the species cannot be ensured. Molecular markers have become an outstanding tool for the evaluation and management of captive breeding programs. Two main genetic objectives should be prioritized when planning breeding programs: the maintenance of maximum neutral genetic diversity, and to obtain "self-sustaining" captive populations. In this study, we use 24 microsatellite loci to analyze and evaluate the genetic representativity of the initial phases of the captive breeding program of the Montseny brook newt, Calotriton arnoldi, an Iberian endemic listed as Critically Endangered. The results show that the initial captive stock has 74-78% of the alleles present in the wild populations, and captures roughly 93-95% of their total genetic diversity as observed in a previous study on wild newts, although it does not reach the desired 97.5%. Moreover, the percentage of unrelatedness among individuals does not exceed 95%. Therefore, we conclude that the genetic diversity of the captive stock should be improved by incorporating genetic material from unrelated wild newts. In recognition of the previously described significant genetic and morphological differentiation between eastern and western wild populations of C. arnoldi, we suggest maintaining two distinct breeding lines, and we do not recommend outbreeding between these lines. Our comparisons of genetic diversity estimates between real and distinct sample-sized simulated populations corroborated that a minimum of 20 individuals are needed for each captive population, in order to match the level of genetic diversity present in the wild populations. Thus, the current initial stock should be reinforced by adding wild specimens. The captive stock and subsequent cohorts should be monitored in order to preserve genetic variation. In order to avoid genetic adaptation to captivity, occasionally

  1. No signs of inbreeding despite long-term isolation and habitat fragmentation in the critically endangered Montseny brook newt (Calotriton arnoldi).

    Science.gov (United States)

    Valbuena-Ureña, E; Soler-Membrives, A; Steinfartz, S; Orozco-terWengel, P; Carranza, S

    2017-05-01

    Endemic species with restricted geographic ranges potentially suffer the highest risk of extinction. If these species are further fragmented into genetically isolated subpopulations, the risk of extinction is elevated. Habitat fragmentation is generally considered to have negative effects on species survival, despite some evidence for neutral or even positive effects. Typically, non-negative effects are ignored by conservation biology. The Montseny brook newt (Calotriton arnoldi) has one of the smallest distribution ranges of any European amphibian (8 km(2)) and is considered critically endangered by the International Union for Conservation of Nature. Here we apply molecular markers to analyze its population structure and find that habitat fragmentation owing to a natural barrier has resulted in strong genetic division of populations into two sectors, with no detectable migration between sites. Although effective population size estimates suggest low values for all populations, we found low levels of inbreeding and relatedness between individuals within populations. Moreover, C. arnoldi displays similar levels of genetic diversity to its sister species Calotriton asper, from which it separated around 1.5 million years ago and which has a much larger distribution range. Our extensive study shows that natural habitat fragmentation does not result in negative genetic effects, such as the loss of genetic diversity and inbreeding on an evolutionary timescale. We hypothesize that species in such conditions may evolve strategies (for example, special mating preferences) to mitigate the effects of small population sizes. However, it should be stressed that the influence of natural habitat fragmentation on an evolutionary timescale should not be conflated with anthropogenic habitat loss or degradation when considering conservation strategies.

  2. Stop and Restart Effects on Modern Vehicle Starting System Components

    Energy Technology Data Exchange (ETDEWEB)

    Windover, Paul R. [Argonne National Lab. (ANL), Argonne, IL (United States); Owens, Russell J. [Argonne National Lab. (ANL), Argonne, IL (United States); Levinson, Terry M. [Argonne National Lab. (ANL), Argonne, IL (United States); Laughlin, Michael [Argonne National Lab. (ANL), Argonne, IL (United States); Gaines, Linda [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-01-01

    Many drivers of personal and commercial vehicles believe that turning the vehicle off and on frequently instead of idling will cause premature wear of the starter system (starter motor and starter battery). As a result, they are concerned that the replacement cost of the starter motor and/or battery due to increased manual engine cycling would be more than the cumulative cost of the fuel saved by not idling unnecessarily. A number of variables play a role in addressing this complex concern, including the number of starting cycles per day, the time between starting cycles, the intended design life of the starting system, the amount of fuel used to restart an engine, and the cumulative cost of the saved fuel. Qualitative and quantitative information from a variety of sources was used to develop a life-cycle economic model to evaluate the cost and quantify the realistic factors that are related to the permissible frequency of starter motor cycles for the average vehicle to economically minimize engine idle time. Annual cost savings can be calculated depending on shutdown duration and the number of shutdown cycles per day. Analysis shows that cost savings are realized by eliminating idling exceeding one minute by shutting down the engine and restarting it. For a typical motorist, the damage to starting system components resulting from additional daily start cycles will be negligible. Overall, it was found that starter life is mostly dependent on the total number of start cycles, while battery life is more dependent on ensuring a full charge between start events.

  3. Krylov subspace method for evaluating the self-energy matrices in electron transport calculations

    DEFF Research Database (Denmark)

    Sørensen, Hans Henrik Brandenborg; Hansen, Per Christian; Petersen, D. E.;

    2008-01-01

    We present a Krylov subspace method for evaluating the self-energy matrices used in the Green's function formulation of electron transport in nanoscale devices. A procedure based on the Arnoldi method is employed to obtain solutions of the quadratic eigenvalue problem associated with the infinite...

  4. On applying weighted seed techniques to GMRES algorithm for solving multiple linear systems

    Directory of Open Access Journals (Sweden)

    Lakhdar Elbouyahyaoui

    2018-07-01

    Full Text Available In the present paper, we are concerned by weighted Arnoldi like methods for solving large and sparse linear systems that have different right-hand sides but have the same coefficient matrix. We first give detailed descriptions of the weighted Gram-Schmidt process and of a Ruhe variant of the weighted block Arnoldi algorithm. We also establish some theoretical results that links the iterates of the weighted block Arnoldi process to those of the non weighted one. Then, to accelerate the convergence of the classical restarted block and seed GMRES methods, we introduce the weighted restarted block and seed GMRES methods. Numerical experiments that are done with different matrices coming from the Matrix Market repository or from the university of Florida sparse matrix collection are reported at the end of this work in order to compare the performance and show the effectiveness of the proposed methods.

  5. RELAP5-3D Resolution of Known Restart/Backup Issues

    Energy Technology Data Exchange (ETDEWEB)

    Mesina, George L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Anderson, Nolan A. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-12-01

    The state-of-the-art nuclear reactor system safety analysis computer program developed at the Idaho National Laboratory (INL), RELAP5-3D, continues to adapt to changes in computer hardware and software and to develop to meet the ever-expanding needs of the nuclear industry. To continue at the forefront, code testing must evolve with both code and industry developments, and it must work correctly. To best ensure this, the processes of Software Verification and Validation (V&V) are applied. Verification compares coding against its documented algorithms and equations and compares its calculations against analytical solutions and the method of manufactured solutions. A form of this, sequential verification, checks code specifications against coding only when originally written then applies regression testing which compares code calculations between consecutive updates or versions on a set of test cases to check that the performance does not change. A sequential verification testing system was specially constructed for RELAP5-3D to both detect errors with extreme accuracy and cover all nuclear-plant-relevant code features. Detection is provided through a “verification file” that records double precision sums of key variables. Coverage is provided by a test suite of input decks that exercise code features and capabilities necessary to model a nuclear power plant. A matrix of test features and short-running cases that exercise them is presented. This testing system is used to test base cases (called null testing) as well as restart and backup cases. It can test RELAP5-3D performance in both standalone and coupled (through PVM to other codes) runs. Application of verification testing revealed numerous restart and backup issues in both standalone and couple modes. This document reports the resolution of these issues.

  6. Mental health effects of the Three Mile Island nuclear reactor restart

    Energy Technology Data Exchange (ETDEWEB)

    Dew, M.A.; Bromet, E.J.; Schulberg, H.C.; Dunn, L.O.; Parkinson, D.K.

    1987-08-01

    Controversy over potential mental health effects of the Three Mile Island Unit-1 restart led the authors to examine prospectively the pattern of psychiatric symptoms in a sample of Three Mile Island area mothers of young children. Symptom levels after restart were elevated over previous levels; a sizable subcohort of the sample reported relatively serious degrees of postrestart distress. History of diagnosable major depression and generalized anxiety following the Three Mile Island accident, plus symptoms and beliefs about personal risk prior to the restart, best predicted postrestart symptoms.

  7. Evaluation of the Doraiswamy-Thompson winter wheat crop calendar model incorporating a modified spring restart sequence

    Science.gov (United States)

    Taylor, T. W.; Ravet, F. W.; Smika, D. (Principal Investigator)

    1981-01-01

    The Robertson phenology was used to provide growth stage information to a wheat stress indicator mode. A stress indicator model demands two acurate predictions from a crop calendar: date of spring growth initiation; and crop calendar stage at growth initiation. Several approaches for restarting the Robertson phenology model at spring growth initiation were studied. Although best results were obtained with a solar thermal unit method, an alternate approach which indicates soil temperature as the controlling parameter for spring growth initiation was selected and tested. The modified model (Doraiswamy-Thompson) is compared to LACIE-Robertson model predictions.

  8. Latest news from the YETS: all restarting except the LHC

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    With the closure of the SPS at 3 p.m. on Friday, 19 February, maintenance work is now ongoing only at the LHC. All activities are on track for a smooth restart in a few weeks’ time.   At the LHC, all general maintenance activities are proceeding well and according to schedule. In particular, the electrical tests on the general emergency stops have been completed, while the cooling and ventilation maintenance, including leak repairs at various points, will be completed by the end of this week for the whole machine. By the end of next week, the teams will also have completed the bakeout and commissioning of all the collimators, while the installation of coaxial cable for clock distribution for CMS TOTEM has been postponed to the Extended Year-End Technical Stop (EYETS), scheduled to start in December. Following a recent decision, additional electrical tests of the circuits (ELQA and energy extraction insulation tests) for the whole machine have been added to the schedule. The SPS is currentl...

  9. Freeze and restart of the DWPF Scale Glass Melter

    Energy Technology Data Exchange (ETDEWEB)

    Choi, A.S.

    1989-07-31

    After over two years of successful demonstration of many design and operating concepts of the DWPF Melter system, the last Scale Glass Melter campaign was initiated on 6/9/88 and consisted of two parts; (1) simulation of noble metal buildup and (2) freeze and subsequent restart of the melter under various scenarios. The objectives were to simulate a prolonged power loss to major heating elements and to examine the characteristics of transient melter operations during a startup with a limited supply of lid heat. Experimental results indicate that in case of a total power loss to the lower electrodes such as due to noble metal deposition, spinel crystals will begin to form in the SRL 165 composite waste glass pool in 24 hours. The total lid heater power required to initiate joule heating was the same as that during slurry-feeding. Results of a radiative heat transfer analysis in the plenum indicate that under the identical operating conditions, the startup capabilities of the SGM and the DWPF Melter are quite similar, despite a greater lid heater to melt surface area ratio in the DWPF Melter.

  10. Online Scheduling with Delivery Time on a Bounded Parallel Batch Machine with Limited Restart

    National Research Council Canada - National Science Library

    Liu, Hailing; Wan, Long; Yan, Zhigang; Yuan, Jinjiang

    2015-01-01

      We consider the online (over time) scheduling of equal length jobs on a bounded parallel batch machine with batch capacity b to minimize the time by which all jobs have been delivered with limited restart...

  11. Modeling of the re-starting of waxy crude oil flows in pipelines; Modelisation du redemarrage des ecoulements de bruts paraffiniques dans les conduites petrolieres

    Energy Technology Data Exchange (ETDEWEB)

    Vinay, G.

    2005-11-15

    Pipelining crude oils that contain large proportions of paraffins can cause many specific difficulties. These oils, known as waxy crude oils, usually exhibit high 'pour point', where this temperature is higher than the external temperature conditions surrounding the pipeline. During the shutdown, since the temperature decreases in the pipeline, the gel-like structure builds up and the main difficulty concerns the issue of restarting. This PhD attempts to improve waxy crude oil behaviour understanding thanks to experiment, modelling and numerical simulation in order to predict more accurately time and pressure required to restart the flow. Using various contributions to the literature, waxy crude oils are described as viscoplastic, thixotropic and compressible fluid. Strong temperature history dependence plays a prevailing role in the whole shutdown and restart process. Thus, waxy crude oils under flowing conditions correspond to the non-isothermal flow of a viscoplastic material with temperature-dependent rheological properties. Besides, the restart of a waxy crude oil is simulated by the isothermal transient flow of a weakly compressible thixotropic fluid in axisymmetric pipe geometry. We retain the Houska model to describe the thixotropic/viscoplastic feature of the fluid and compressibility is introduced in the continuity equation. The viscoplastic constitutive equation is involved using an augmented Lagrangian method and the resulting equivalent saddle-point problem is solved thanks to an Uzawa-like algorithm. Governing equations are discretized using a Finite Volume method and the convection terms are treated thanks to a TVD (Total Variation Diminishing) scheme. The Lagrangian functional technique usually used for incompressible viscoplastic flows, is adapted to compressible situations. Several numerical results attest the good convergence properties of the proposed transient algorithm. The non-isothermal results highlight the strong sensitivity of

  12. Fast parallel MR image reconstruction via B1-based, adaptive restart, iterative soft thresholding algorithms (BARISTA).

    Science.gov (United States)

    Muckley, Matthew J; Noll, Douglas C; Fessler, Jeffrey A

    2015-02-01

    Sparsity-promoting regularization is useful for combining compressed sensing assumptions with parallel MRI for reducing scan time while preserving image quality. Variable splitting algorithms are the current state-of-the-art algorithms for SENSE-type MR image reconstruction with sparsity-promoting regularization. These methods are very general and have been observed to work with almost any regularizer; however, the tuning of associated convergence parameters is a commonly-cited hindrance in their adoption. Conversely, majorize-minimize algorithms based on a single Lipschitz constant have been observed to be slow in shift-variant applications such as SENSE-type MR image reconstruction since the associated Lipschitz constants are loose bounds for the shift-variant behavior. This paper bridges the gap between the Lipschitz constant and the shift-variant aspects of SENSE-type MR imaging by introducing majorizing matrices in the range of the regularizer matrix. The proposed majorize-minimize methods (called BARISTA) converge faster than state-of-the-art variable splitting algorithms when combined with momentum acceleration and adaptive momentum restarting. Furthermore, the tuning parameters associated with the proposed methods are unitless convergence tolerances that are easier to choose than the constraint penalty parameters required by variable splitting algorithms.

  13. Reasons Why Children and Adolescents with ADHD Stop and Restart Taking Medicine.

    Science.gov (United States)

    Brinkman, William B; Simon, John O; Epstein, Jeffery N

    2017-09-12

    To describe the prevalence of reasons why children and adolescents stop and restart attention-deficit/hyperactivity disorder (ADHD) medicine and whether functional impairment is present after stopping medicine. We used the prospective longitudinal cohort from the Multimodal Treatment of Study of Children with ADHD. At the 12 year follow-up when participants were a mean of 21.1 years old, 372 participants (76% male, 64% Caucasian) reported ever taking ADHD medicine. Participants reported the age when they last stopped and/or restarted ADHD medicine and also endorsed reasons for stopping and restarting. Seventy-seven percent (286/372) reported stopping medicine for a month or longer at some time during childhood or adolescence. Participants were a mean of 13.3 years old when they last stopped medicine. The most commonly endorsed reasons for stopping medication related to 1) medicine not needed/helping, 2) side effects, 3) logistical barriers of getting/taking medication, and 4) social concerns/stigma. Seventeen percent (64/372) reported restarting medicine after stopping for a month or longer. Commonly endorsed reasons for restarting related to 1) medicine needed/helped, 2) resolution of logistical barriers to getting/taking. For both stopping and restarting, the proportion endorsing some reasons differed by age range, with the overall pattern suggesting that parental involvement in decisions decreased with age. Nearly all participants had impairment at the assessment after stopping regardless of whether medication was resumed. Different reasons for stopping and/or restarting medicine are relevant at different times for different teens. Tailored strategies may help engage adolescents as full partners in their treatment plan. Copyright © 2017. Published by Elsevier Inc.

  14. Safety Evaluation Report Restart of K-Reactor Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    In April 1991, the Department of Energy (DOE) issued DOE/DP-0084T, Safety Evaluation Report Restart of K-Reactor Savannah River Site.'' The Safety Evaluation Report (SER) documents the results of DOE reviews and evaluations of the programmatic aspects of a large number of issues necessary to be satisfactorily addressed before restart. The issues were evaluated for compliance with the restart criteria included in the SER. The results of those evaluations determined that the restart criteria had been satisfied for some of the issues. However, for most of the issues at least part of the applicable restart criteria had not been found to be satisfied at the time the evaluations were prepared. For those issues, open or confirmatory items were identified that required resolution. In August 1991, DOE issued DOE/DP-0090T, Safety Evaluation Report Restart of K-Reactor Savannah River Site Supplement 1.'' That document was the first Supplement to the April 1991 SER, and documented the resolution of 62 of the open items identified in the SER. This document is the second Supplement to the April 1991 SER. This second SER Supplement documents the resolution of additional open times identified in the SER, and includes a complete list of all remaining SER open items. The resolution of those remaining open items will be documented in future SER Supplements. Resolution of all open items for an issue indicates that its associated restart criteria have been satisfied, and that DOE concludes that the programmatic aspects of the issue have been satisfactorily addressed.

  15. Operational Readiness Review Final Report For F-Canyon Restart. Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    McFarlane, A.F.; Spangler, J.B.

    1995-04-05

    An independent WSRC Operational Readiness Review was performed for the restart of Phase 1 processing in F-Canyon, Building 221-F. Readiness to restart the Second Plutonium Cycle process and solvent recovery was assessed. The ORR was conducted by an ORR board of ten members with the support of a subject matter expert. The chairman and four members were drawn from the Operational Safety Evaluation Department, ESH& QA Division; additional members were drawn from other WSRC divisions, independent of the F-Canyon operating division (NMPD). Based on the results of the readiness verification assessments performed according to the ORR plan and the validation of pre-restart corrective actions, the WSRC independent ORR Board has concluded that the facility has achieved the state of readiness committed to in the Restart Plan. Also, based on the scope of the ORR, it is the opinion of the board that F-Canyon Phase 1 processes can be restarted without undue risk to the safety of the public and onsite workers and without undue risk to the environment.

  16. [Safely restarting antithrombotic treatment after a gastrointestinal bleed: evidence or gut feeling?].

    Science.gov (United States)

    van der Worp, H Bart

    2016-01-01

    Guidelines for the management of non-variceal upper gastrointestinal haemorrhage recommend restarting anticoagulant therapy after treatment of the haemorrhage in patients with an indication for anticoagulation, such as atrial fibrillation. This recommendation is based on findings in retrospective observational studies, and probably also on common sense: if the cause of the haemorrhage has been treated, the chance of a life-threatening second gastrointestinal haemorrhage when anticoagulation is restarted is likely to be smaller than the chance of a serious thromboembolic complication if anticoagulation is stopped indefinitely. A new, large observational study in patients with atrial fibrillation who had a gastrointestinal bleed while receiving antithrombotic treatment suggests that a restart of oral anticoagulation is associated with a lower risk of death and thromboembolic complications than not resuming anticoagulation, and that the risk of a recurrent bleed is slight. Unfortunately, methodological limitations inherent to most observational studies limit the usefulness of the findings to individual patient cases.

  17. Multiple genetic pathways for restarting DNA replication forks in Escherichia coli K-12.

    OpenAIRE

    Sandler, S J

    2000-01-01

    In Escherichia coli, the primosome assembly proteins, PriA, PriB, PriC, DnaT, DnaC, DnaB, and DnaG, are thought to help to restart DNA replication forks at recombinational intermediates. Redundant functions between priB and priC and synthetic lethality between priA2::kan and rep3 mutations raise the possibility that there may be multiple pathways for restarting replication forks in vivo. Herein, it is shown that priA2::kan causes synthetic lethality when placed in combination with either Delt...

  18. The efficacy of a restart break for recycling with optimal performance depends critically on circadian timing.

    Science.gov (United States)

    Van Dongen, Hans P A; Belenky, Gregory; Vila, Bryan J

    2011-07-01

    Under simulated shift-work conditions, we investigated the efficacy of a restart break for maintaining neurobehavioral functioning across consecutive duty cycles, as a function of the circadian timing of the duty periods. As part of a 14-day experiment, subjects underwent two cycles of five simulated daytime or nighttime duty days, separated by a 34-hour restart break. Cognitive functioning and high-fidelity driving simulator performance were tested 4 times per day during the two duty cycles. Lapses on a psychomotor vigilance test (PVT) served as the primary outcome variable. Selected sleep periods were recorded polysomnographically. The experiment was conducted under standardized, controlled laboratory conditions with continuous monitoring. Twenty-seven healthy adults (13 men, 14 women; aged 22-39 years) participated in the study. Subjects were randomly assigned to a nighttime duty (experimental) condition or a daytime duty (control) condition. The efficacy of the 34-hour restart break for maintaining neurobehavioral functioning from the pre-restart duty cycle to the post-restart duty cycle was compared between these two conditions. Relative to the daytime duty condition, the nighttime duty condition was associated with reduced amounts of sleep, whereas sleep latencies were shortened and slow-wave sleep appeared to be conserved. Neurobehavioral performance measures ranging from lapses of attention on the PVT to calculated fuel consumption on the driving simulators remained optimal across time of day in the daytime duty schedule, but degraded across time of night in the nighttime duty schedule. The 34-hour restart break was efficacious for maintaining PVT performance and other objective neurobehavioral functioning profiles from one duty cycle to the next in the daytime duty condition, but not in the nighttime duty condition. Subjective sleepiness did not reliably track objective neurobehavioral deficits. The 34-hour restart break was adequate for maintaining

  19. Increased capability gas generator for Space Shuttle APU. Development/hot restart test report

    Science.gov (United States)

    1980-01-01

    The design, fabrication, and testing of an increased capability gas generator for use in space shuttles are described. Results show an unlimited hot restart capability in the range of feed pressures from 400 psi to 80 psi. Effects of vacuum on hot restart were not addressed, and only beginning-of-life bed conditions were tested. No starts with bubbles were performed. A minimum expected life of 35 hours or more is projected, and the design will maintain a surface temperature of 350 F or more.

  20. 78 FR 69367 - Golden Valley Electric Association: Healy Power Plant Unit #2 Restart

    Science.gov (United States)

    2013-11-19

    ... the restart of Unit 2 and for improvements to the Healy Plant, which include installing additional emissions control to both Unit 1 and Unit 2. Unit 1 is a 25 MW coal-fired boiler and Unit 2 is a 50 MW coal-fired boiler that was constructed in the late 1990s with funding from DOE and AIDEA. The...

  1. Removal of floating organic in Hanford Waste Tank 241-C-103 restart plan

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, T.R.; Hanson, C.

    1994-10-03

    The decision whether or not to remove the organic layer from Waste Tank 241-C-103 was deferred until May, 1995. The following restart plan was prepared for removal of the organic if the decision is to remove the organic from the waste tank 241-C-103.

  2. Restart Plan for the Prototype Vertical Denitration Calciner [SD Coversheet has Incorrect Document Number

    Energy Technology Data Exchange (ETDEWEB)

    SUTTER, C.S.

    1999-07-26

    Testing activities on the Prototype Vertical Denitration Calciner at PFP were suspended in January 1997 due to the hold on fissile material handling in the facility. The Restart Plan will govern the transition of the test program from the completion of the activity based startup review; through equipment checkout and surrogate material runs; to resumption of the testing program and transition to unrestricted testing.

  3. Automatic Fault-Tolerance Support in Resource Management System Based on Job Checkpoint/Restart%资源管理系统中基于作业检查点的自动容错

    Institute of Scientific and Technical Information of China (English)

    曹宏嘉; 卢宇彤; 谢旻

    2009-01-01

    An automatic fault-tolerance method based on job checkpoint/restart in resource management systems is pro-posed The key technologies are presented, including the separation of job checkpoint and task checkpoint, management of checkpoint image files, and automatic job restart.Automatic job checkpoint/restart with BLCR is implemented in SLURM and the challenges are discussed. Analysis and experiments show that the checkpoint and restart works correctly, and the time to complete large-scale jobs is reduced effectively.%本文提出了在资源管理系统中基于作业检查点实现自动容错支持,深入分析了作业与任务检查点分离、映像文件管理、自动恢复执行等关键技术.基于BLCR在SLURM中实现了作业的自动检查点/恢复,详细介绍了实现中的关键技术难题.分析与测试表明,检查点与恢复执行功能正确,并能有效缩短大规模作业成功运行所需的时间.

  4. Final Report for the Restart of the Waste Characterization, Reduction and Repackaging Facility (WCRRF) Contractor Readiness Assessment (CRA)

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, Gregory Mark [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-22

    The Los Alamos National Laboratory (LANL or Laboratory) Contractor Readiness Assessment (CRA) required for restart of the Technical Area (TA) 50 Waste Characterization, Reduction, and Repackaging Facility (WCRRF) for remediated nitrate salt (RNS) waste operations was performed in compliance with the requirements of Department of Energy (DOE) Order (O) 425.1D, Verification of Readiness to Start Up or Restart Nuclear Facilities, and LANL procedure FSD-115-001, Verification of Readiness to Start Up or Restart LANL Nuclear Facilities, Activities, and Operations.

  5. Naturalistic field study of the restart break in US commercial motor vehicle drivers: Truck driving, sleep, and fatigue.

    Science.gov (United States)

    Sparrow, Amy R; Mollicone, Daniel J; Kan, Kevin; Bartels, Rachel; Satterfield, Brieann C; Riedy, Samantha M; Unice, Aaron; Van Dongen, Hans P A

    2016-08-01

    Commercial motor vehicle (CMV) drivers in the US may start a new duty cycle after taking a 34-h restart break. A restart break provides an opportunity for sleep recuperation to help prevent the build-up of fatigue across duty cycles. However, the effectiveness of a restart break may depend on its timing, and on how many nighttime opportunities for sleep it contains. For daytime drivers, a 34-h restart break automatically includes two nighttime periods. For nighttime drivers, who are arguably at increased risk of fatigue, a 34-h restart break contains only one nighttime period. To what extent this is relevant for fatigue depends in part on whether nighttime drivers revert back to a nighttime-oriented sleep schedule during the restart break. We conducted a naturalistic field study with 106 CMV drivers working their normal schedules and performing their normal duties. These drivers were studied during two duty cycles and during the intervening restart break. They provided a total of 1260days of data and drove a total of 414,937 miles during the study. Their duty logs were used to identify the periods when they were on duty and when they were driving and to determine their duty cycles and restart breaks. Sleep/wake patterns were measured continuously by means of wrist actigraphy. Fatigue was assessed three times per day by means of a brief psychomotor vigilance test (PVT-B) and a subjective sleepiness scale. Data from a truck-based lane tracking and data acquisition system were used to compute lane deviation (variability in lateral lane position). Statistical analyses focused on 24-h patterns of duty, driving, sleep, PVT-B performance, subjective sleepiness, and lane deviation. Duty cycles preceded by a restart break containing only one nighttime period (defined as 01:00-05:00) were compared with duty cycles preceded by a restart break containing more than one nighttime period. During duty cycles preceded by a restart break with only one nighttime period, drivers

  6. Use of Checkpoint-Restart for Complex HEP Software on Traditional Architectures and Intel MIC

    CERN Document Server

    Arya, Kapil; Dotti, Andrea; Elmer, Peter

    2013-01-01

    Process checkpoint-restart is a technology with great potential for use in HEP workflows. Use cases include debugging, reducing the startup time of applications both in offline batch jobs and the High Level Trigger, permitting job preemption in environments where spare CPU cycles are being used opportunistically and efficient scheduling of a mix of multicore and single-threaded jobs. We report on tests of checkpoint-restart technology using CMS software, Geant4-MT (multi-threaded Geant4), and the DMTCP (Distributed Multithreaded Checkpointing) package. We analyze both single- and multi-threaded applications and test on both standard Intel x86 architectures and on Intel MIC. The tests with multi-threaded applications on Intel MIC are used to consider scalability and performance. These are considered an indicator of what the future may hold for many-core computing.

  7. The design and implementation of Berkeley Lab's linuxcheckpoint/restart

    Energy Technology Data Exchange (ETDEWEB)

    Duell, Jason

    2005-04-30

    This paper describes Berkeley Linux Checkpoint/Restart (BLCR), a linux kernel module that allows system-level checkpoints on a variety of Linux systems. BLCR can be used either as a stand alone system for checkpointing applications on a single machine, or as a component by a scheduling system or parallel communication library for checkpointing and restoring parallel jobs running on multiple machines. Integration with Message Passing Interface (MPI) and other parallel systems is described.

  8. An intelligent multi-restart memetic algorithm for box constrained global optimisation.

    Science.gov (United States)

    Sun, J; Garibaldi, J M; Krasnogor, N; Zhang, Q

    2013-01-01

    In this paper, we propose a multi-restart memetic algorithm framework for box constrained global continuous optimisation. In this framework, an evolutionary algorithm (EA) and a local optimizer are employed as separated building blocks. The EA is used to explore the search space for very promising solutions (e.g., solutions in the attraction basin of the global optimum) through its exploration capability and previous EA search history, and local search is used to improve these promising solutions to local optima. An estimation of distribution algorithm (EDA) combined with a derivative free local optimizer, called NEWUOA (M. Powell, Developments of NEWUOA for minimization without derivatives. Journal of Numerical Analysis, 28:649-664, 2008), is developed based on this framework and empirically compared with several well-known EAs on a set of 40 commonly used test functions. The main components of the specific algorithm include: (1) an adaptive multivariate probability model, (2) a multiple sampling strategy, (3) decoupling of the hybridisation strategy, and (4) a restart mechanism. The adaptive multivariate probability model and multiple sampling strategy are designed to enhance the exploration capability. The restart mechanism attempts to make the search escape from local optima, resorting to previous search history. Comparison results show that the algorithm is comparable with the best known EAs, including the winner of the 2005 IEEE Congress on Evolutionary Computation (CEC2005), and significantly better than the others in terms of both the solution quality and computational cost.

  9. Michaelis-Menten reaction scheme as a unified approach towards the optimal restart problem.

    Science.gov (United States)

    Rotbart, Tal; Reuveni, Shlomi; Urbakh, Michael

    2015-12-01

    We study the effect of restart, and retry, on the mean completion time of a generic process. The need to do so arises in various branches of the sciences and we show that it can naturally be addressed by taking advantage of the classical reaction scheme of Michaelis and Menten. Stopping a process in its midst-only to start it all over again-may prolong, leave unchanged, or even shorten the time taken for its completion. Here we are interested in the optimal restart problem, i.e., in finding a restart rate which brings the mean completion time of a process to a minimum. We derive the governing equation for this problem and show that it is exactly solvable in cases of particular interest. We then continue to discover regimes at which solutions to the problem take on universal, details independent forms which further give rise to optimal scaling laws. The formalism we develop, and the results obtained, can be utilized when optimizing stochastic search processes and randomized computer algorithms. An immediate connection with kinetic proofreading is also noted and discussed.

  10. Michaelis-Menten reaction scheme as a unified approach towards the optimal restart problem

    Science.gov (United States)

    Rotbart, Tal; Reuveni, Shlomi; Urbakh, Michael

    2015-12-01

    We study the effect of restart, and retry, on the mean completion time of a generic process. The need to do so arises in various branches of the sciences and we show that it can naturally be addressed by taking advantage of the classical reaction scheme of Michaelis and Menten. Stopping a process in its midst—only to start it all over again—may prolong, leave unchanged, or even shorten the time taken for its completion. Here we are interested in the optimal restart problem, i.e., in finding a restart rate which brings the mean completion time of a process to a minimum. We derive the governing equation for this problem and show that it is exactly solvable in cases of particular interest. We then continue to discover regimes at which solutions to the problem take on universal, details independent forms which further give rise to optimal scaling laws. The formalism we develop, and the results obtained, can be utilized when optimizing stochastic search processes and randomized computer algorithms. An immediate connection with kinetic proofreading is also noted and discussed.

  11. RDEL: Restart Differential Evolution algorithm with Local Search Mutation for global numerical optimization

    Directory of Open Access Journals (Sweden)

    Ali Wagdy Mohamed

    2014-11-01

    Full Text Available In this paper, a novel version of Differential Evolution (DE algorithm based on a couple of local search mutation and a restart mechanism for solving global numerical optimization problems over continuous space is presented. The proposed algorithm is named as Restart Differential Evolution algorithm with Local Search Mutation (RDEL. In RDEL, inspired by Particle Swarm Optimization (PSO, a novel local mutation rule based on the position of the best and the worst individuals among the entire population of a particular generation is introduced. The novel local mutation scheme is joined with the basic mutation rule through a linear decreasing function. The proposed local mutation scheme is proven to enhance local search tendency of the basic DE and speed up the convergence. Furthermore, a restart mechanism based on random mutation scheme and a modified Breeder Genetic Algorithm (BGA mutation scheme is combined to avoid stagnation and/or premature convergence. Additionally, an exponent increased crossover probability rule and a uniform scaling factors of DE are introduced to promote the diversity of the population and to improve the search process, respectively. The performance of RDEL is investigated and compared with basic differential evolution, and state-of-the-art parameter adaptive differential evolution variants. It is discovered that the proposed modifications significantly improve the performance of DE in terms of quality of solution, efficiency and robustness.

  12. Sensitive assessment of the virologic outcomes of stopping and restarting non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy.

    Directory of Open Access Journals (Sweden)

    Anna Maria Geretti

    Full Text Available BACKGROUND: Non-nucleoside reverse transcriptase inhibitor (NNRTI-resistant mutants have been shown to emerge after interruption of suppressive NNRTI-based antiretroviral therapy (ART using routine testing. The aim of this study was to quantify the risk of resistance by sensitive testing and correlate the detection of resistance with NNRTI concentrations after treatment interruption and virologic responses after treatment resumption. METHODS: Resistance-associated mutations (RAMs and NNRTI concentrations were studied in plasma from 132 patients who interrupted suppressive ART within SMART. RAMs were detected by Sanger sequencing, allele-specific PCR, and ultra-deep sequencing. NNRTI concentrations were measured by sensitive high-performance liquid chromatography. RESULTS: Four weeks after NNRTI interruption, 19/31 (61.3% and 34/39 (87.2% patients showed measurable nevirapine (>0.25 ng/ml or efavirenz (>5 ng/ml concentrations, respectively. Median eight weeks after interruption, 22/131 (16.8% patients showed ≥1 NNRTI-RAM, including eight patients with NNRTI-RAMs detected only by sensitive testing. The adjusted odds ratio (OR of NNRTI-RAM detection was 7.62 (95% confidence interval [CI] 1.52, 38.30; p = 0.01 with nevirapine or efavirenz concentrations above vs. below the median measured in the study population. Staggered interruption, whereby nucleos(tide reverse transcriptase inhibitors (NRTIs were continued for median nine days after NNRTI interruption, did not prevent NNRTI-RAMs, but increased detection of NRTI-RAMs (OR 4.25; 95% CI 1.02, 17.77; p = 0.03. After restarting NNRTI-based ART (n = 90, virologic suppression rates <400 copies/ml were 8/13 (61.5% with NNRTI-RAMs, 7/11 (63.6% with NRTI-RAMs only, and 51/59 (86.4% without RAMs. The ORs of re-suppression were 0.18 (95% CI 0.03, 0.89 and 0.17 (95% CI 0.03, 1.15 for patients with NNRTI-RAMs or NRTI-RAMs only respectively vs. those without RAMs (p = 0.04. CONCLUSIONS

  13. Analyzing the spectrum of general, non-hermitian Dirac operators

    CERN Document Server

    Gattringer, C R; Gattringer, Christof; Hip, Ivan

    1999-01-01

    We discuss the computational problems when analyzing general, non-hermitian matrices and in particular the un-modified Wilson lattice Dirac operator. We report on our experiences with the Implicitly Restarted Arnoldi Method. The eigenstates of the Wilson-Dirac operator which have real eigenvalues and correspond to zero modes in the continuum are analyzed by correlating the size of the eigenvalues with the chirality of the eigenstates.

  14. A portable implementation of ARPACK for distributed memory parallel architectures

    Energy Technology Data Exchange (ETDEWEB)

    Maschhoff, K.J.; Sorensen, D.C.

    1996-12-31

    ARPACK is a package of Fortran 77 subroutines which implement the Implicitly Restarted Arnoldi Method used for solving large sparse eigenvalue problems. A parallel implementation of ARPACK is presented which is portable across a wide range of distributed memory platforms and requires minimal changes to the serial code. The communication layers used for message passing are the Basic Linear Algebra Communication Subprograms (BLACS) developed for the ScaLAPACK project and Message Passing Interface(MPI).

  15. Rheology and FTIR studies of model waxy crude oils with relevance to gelled pipeline restart

    Energy Technology Data Exchange (ETDEWEB)

    Magda, J.J.; Guimeraes, K.; Deo, M.D. [Utah Univ., Salt Lake City, UT (United States). Dept. of Chemical Engineering; Venkatesan, R.; Montesi, A. [Chevron Energy Technology Co., Houston, TX (United States)

    2008-07-01

    Gels composed of wax crystals may sometimes form when crude oils are transported in pipelines when ambient temperatures are low. The gels may stop the pipe flow, making it difficult or even impossible to restart the flow without breaking the pipe. Rheology and FTIR techniques were used to study the problem and to characterize transparent model waxy crude oils in pipeline flow experiments. These model oils were formulated without any highly volatile components to enhance the reproducibility of the rheology tests. Results were presented for the time- and temperature-dependent rheology of the model waxy crude oils as obtained in linear oscillatory shear and in creep-recovery experiments. The model oils were shown to exhibit many of the rheological features reported for real crude oils, such as 3 distinct apparent yield stresses, notably static yield stress, dynamic yield stress, and elastic-limit yield stress. It was concluded that of the 3, the static yield stress value, particularly its time dependence, can best be used to predict the restart behaviour observed for the same gel in model pipelines.

  16. Quantification of the fungal fraction released from various preloaded fibrous filters during a simulated ventilation restart.

    Science.gov (United States)

    Morisseau, K; Joubert, A; Le Coq, L; Andres, Y

    2017-05-01

    This study aimed to demonstrate that particles, especially those associated with fungi, could be released from fibrous filters used in the air-handling unit (AHU) of heating, ventilation and air-conditioning (HVAC) systems during ventilation restarts. Quantification of the water retention capacity and SEM pictures of the filters was used to show the potential for fungal proliferation in unused or preloaded filters. Five fibrous filters with various particle collection efficiencies were studied: classes G4, M5, M6, F7, and combined F7 according to European standard EN779:2012. Filters were clogged with micronized rice particles containing the fungus Penicillium chrysogenum and then incubated for three weeks at 25°C and 90% relative humidity. The results indicated that the five clogged tested filters had various fungal growth capacities depending on their water retention capacity. Preloaded filters were subjected to a simulated ventilation restart in a controlled filtration device to quantify that the fraction of particles released was around 1% for the G4, 0.1% for the M5 and the M6, and 0.001% for the F7 and the combined F7 filter. The results indicate that the likelihood of fungal particle release by low efficiency filters is significantly higher than by high efficiency filters. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. A regularized GMRES method for inverse blackbody radiation problem

    Directory of Open Access Journals (Sweden)

    Wu Jieer

    2013-01-01

    Full Text Available The inverse blackbody radiation problem is focused on determining temperature distribution of a blackbody from measured total radiated power spectrum. This problem consists of solving a first kind of Fredholm integral equation and many numerical methods have been proposed. In this paper, a regularized GMRES method is presented to solve the linear ill-posed problem caused by the discretization of such an integral equation. This method projects the orignal problem onto a lower dimensional subspaces by the Arnoldi process. Tikhonov regularization combined with GCV criterion is applied to stabilize the numerical iteration process. Three numerical examples indicate the effectiveness of the regularized GMRES method.

  18. Asynchronous Checkpoint Migration with MRNet in the Scalable Checkpoint / Restart Library

    Energy Technology Data Exchange (ETDEWEB)

    Mohror, K; Moody, A; de Supinski, B R

    2012-03-20

    Applications running on today's supercomputers tolerate failures by periodically saving their state in checkpoint files on stable storage, such as a parallel file system. Although this approach is simple, the overhead of writing the checkpoints can be prohibitive, especially for large-scale jobs. In this paper, we present initial results of an enhancement to our Scalable Checkpoint/Restart Library (SCR). We employ MRNet, a tree-based overlay network library, to transfer checkpoints from the compute nodes to the parallel file system asynchronously. This enhancement increases application efficiency by removing the need for an application to block while checkpoints are transferred to the parallel file system. We show that the integration of SCR with MRNet can reduce the time spent in I/O operations by as much as 15x. However, our experiments exposed new scalability issues with our initial implementation. We discuss the sources of the scalability problems and our plans to address them.

  19. Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse

    Science.gov (United States)

    Nguyen, Michael O; Jalan, Manisha; Morrow, Carl A; Osman, Fekret; Whitby, Matthew C

    2015-01-01

    The completion of genome duplication during the cell cycle is threatened by the presence of replication fork barriers (RFBs). Following collision with a RFB, replication proteins can dissociate from the stalled fork (fork collapse) rendering it incapable of further DNA synthesis unless recombination intervenes to restart replication. We use time-lapse microscopy and genetic assays to show that recombination is initiated within ∼10 min of replication fork blockage at a site-specific barrier in fission yeast, leading to a restarted fork within ∼60 min, which is only prevented/curtailed by the arrival of the opposing replication fork. The restarted fork is susceptible to further collapse causing hyper-recombination downstream of the barrier. Surprisingly, in our system fork restart is unnecessary for maintaining cell viability. Seemingly, the risk of failing to complete replication prior to mitosis is sufficient to warrant the induction of recombination even though it can cause deleterious genetic change. DOI: http://dx.doi.org/10.7554/eLife.04539.001 PMID:25806683

  20. Getting to First Flight: Equipping Space Engineers to Break the Start-Stop-Restart Cycle

    Science.gov (United States)

    Singer, Christopher E.; Dumbacher, Daniel L.

    2010-01-01

    The National Aeronautics and Space Administration s (NASA s) history is built on a foundation of can-do strength, while pointing to the Saturn/Apollo Moon missions in the 1960s and 1970s as its apex a sentiment that often overshadows the potential that lies ahead. The chronicle of America s civil space agenda is scattered with programs that got off to good starts with adequate resources and vocal political support but that never made it past a certain milestone review, General Accountability Office report, or Congressional budget appropriation. Over the decades since the fielding of the Space Shuttle in the early 1980s, a start-stop-restart cycle has intervened due to many forces. Despite this impediment, the workforce has delivered engineering feats such as the International Space Station and numerous Shuttle and science missions, which reflect a trend in the early days of the Exploration Age that called for massive infrastructure and matching capital allocations. In the new millennium, the aerospace industry must respond to transforming economic climates, the public will, national agendas, and international possibilities relative to scientific exploration beyond Earth s orbit. Two pressing issues - workforce transition and mission success - are intertwined. As this paper will address, U.S. aerospace must confront related workforce development and industrial base issues head on to take space exploration to the next level. This paper also will formulate specific strategies to equip space engineers to move beyond the seemingly constant start-stop-restart mentality to plan and execute flight projects that actually fly.

  1. Eigensolutions to a vibroacoustic interior coupled problem with a perturbation method

    Science.gov (United States)

    Claude, Bertille; Duigou, Laetitia; Girault, Gregory; Cadou, Jean-Marc

    2017-02-01

    In this paper, an efficient and robust numerical method is proposed to solve non-symmetric eigenvalue problems resulting from the spatial discretization with the finite element method of a vibroacoustic interior problem. The proposed method relies on a perturbation method. Finding the eigenvalues consists in determining zero values of a scalar that depends on angular frequency. Numerical tests show that the proposed method is not sensitive to poorly conditioned matrices resulting from the displacement-pressure formulation. Moreover, the computational times required with this method are lower than those needed with a classical technique such as, for example, the Arnoldi method.

  2. Identifying and Analyzing Novel Epilepsy-Related Genes Using Random Walk with Restart Algorithm

    Directory of Open Access Journals (Sweden)

    Wei Guo

    2017-01-01

    Full Text Available As a pathological condition, epilepsy is caused by abnormal neuronal discharge in brain which will temporarily disrupt the cerebral functions. Epilepsy is a chronic disease which occurs in all ages and would seriously affect patients’ personal lives. Thus, it is highly required to develop effective medicines or instruments to treat the disease. Identifying epilepsy-related genes is essential in order to understand and treat the disease because the corresponding proteins encoded by the epilepsy-related genes are candidates of the potential drug targets. In this study, a pioneering computational workflow was proposed to predict novel epilepsy-related genes using the random walk with restart (RWR algorithm. As reported in the literature RWR algorithm often produces a number of false positive genes, and in this study a permutation test and functional association tests were implemented to filter the genes identified by RWR algorithm, which greatly reduce the number of suspected genes and result in only thirty-three novel epilepsy genes. Finally, these novel genes were analyzed based upon some recently published literatures. Our findings implicate that all novel genes were closely related to epilepsy. It is believed that the proposed workflow can also be applied to identify genes related to other diseases and deepen our understanding of the mechanisms of these diseases.

  3. Identifying and Analyzing Novel Epilepsy-Related Genes Using Random Walk with Restart Algorithm

    Science.gov (United States)

    Guo, Wei; Shang, Dong-Mei; Cao, Jing-Hui; Feng, Kaiyan; Wang, ShaoPeng

    2017-01-01

    As a pathological condition, epilepsy is caused by abnormal neuronal discharge in brain which will temporarily disrupt the cerebral functions. Epilepsy is a chronic disease which occurs in all ages and would seriously affect patients' personal lives. Thus, it is highly required to develop effective medicines or instruments to treat the disease. Identifying epilepsy-related genes is essential in order to understand and treat the disease because the corresponding proteins encoded by the epilepsy-related genes are candidates of the potential drug targets. In this study, a pioneering computational workflow was proposed to predict novel epilepsy-related genes using the random walk with restart (RWR) algorithm. As reported in the literature RWR algorithm often produces a number of false positive genes, and in this study a permutation test and functional association tests were implemented to filter the genes identified by RWR algorithm, which greatly reduce the number of suspected genes and result in only thirty-three novel epilepsy genes. Finally, these novel genes were analyzed based upon some recently published literatures. Our findings implicate that all novel genes were closely related to epilepsy. It is believed that the proposed workflow can also be applied to identify genes related to other diseases and deepen our understanding of the mechanisms of these diseases.

  4. DNA replication restart and cellular dynamics of Hef helicase/nuclease protein in Haloferax volcanii.

    Science.gov (United States)

    Lestini, Roxane; Delpech, Floriane; Myllykallio, Hannu

    2015-11-01

    Understanding how frequently spontaneous replication arrests occur and how archaea deal with these arrests are very interesting and challenging research topics. Here we will described how genetic and imaging studies have revealed the central role of the archaeal helicase/nuclease Hef belonging to the XPF/MUS81/FANCM family of endonucleases in repair of arrested replication forks. Special focus will be on description of a recently developed combination of genetic and imaging tools to study the dynamic localization of a functional Hef::GFP (Green Fluorescent Protein) fusion protein in the living cells of halophilic archaea Haloferax volcanii. As Archaea provide an excellent and unique model for understanding how DNA replication is regulated to allow replication of a circular DNA molecule either from single or multiple replication origins, we will also summarize recent studies that have revealed peculiar features regarding DNA replication, particularly in halophilic archaea. We strongly believe that fundamental knowledge of our on-going studies will shed light on the evolutionary history of the DNA replication machinery and will help to establish general rules concerning replication restart and the key role of recombination proteins not only in bacteria, yeast and higher eukaryotes but also in archaea.

  5. Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.

    Science.gov (United States)

    Shuhaibar, Leia C; Egbert, Jeremy R; Norris, Rachael P; Lampe, Paul D; Nikolaev, Viacheslav O; Thunemann, Martin; Wen, Lai; Feil, Robert; Jaffe, Laurinda A

    2015-04-28

    Meiosis in mammalian oocytes is paused until luteinizing hormone (LH) activates receptors in the mural granulosa cells of the ovarian follicle. Prior work has established the central role of cyclic GMP (cGMP) from the granulosa cells in maintaining meiotic arrest, but it is not clear how binding of LH to receptors that are located up to 10 cell layers away from the oocyte lowers oocyte cGMP and restarts meiosis. Here, by visualizing intercellular trafficking of cGMP in real-time in live follicles from mice expressing a FRET sensor, we show that diffusion of cGMP through gap junctions is responsible not only for maintaining meiotic arrest, but also for rapid transmission of the signal that reinitiates meiosis from the follicle surface to the oocyte. Before LH exposure, the cGMP concentration throughout the follicle is at a uniformly high level of ∼2-4 μM. Then, within 1 min of LH application, cGMP begins to decrease in the peripheral granulosa cells. As a consequence, cGMP from the oocyte diffuses into the sink provided by the large granulosa cell volume, such that by 20 min the cGMP concentration in the follicle is uniformly low, ∼100 nM. The decrease in cGMP in the oocyte relieves the inhibition of the meiotic cell cycle. This direct demonstration that a physiological signal initiated by a stimulus in one region of an intact tissue can travel across many layers of cells via cyclic nucleotide diffusion through gap junctions could provide a general mechanism for diverse cellular processes.

  6. Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles

    Science.gov (United States)

    Shuhaibar, Leia C.; Egbert, Jeremy R.; Norris, Rachael P.; Lampe, Paul D.; Nikolaev, Viacheslav O.; Thunemann, Martin; Wen, Lai; Feil, Robert; Jaffe, Laurinda A.

    2015-01-01

    Meiosis in mammalian oocytes is paused until luteinizing hormone (LH) activates receptors in the mural granulosa cells of the ovarian follicle. Prior work has established the central role of cyclic GMP (cGMP) from the granulosa cells in maintaining meiotic arrest, but it is not clear how binding of LH to receptors that are located up to 10 cell layers away from the oocyte lowers oocyte cGMP and restarts meiosis. Here, by visualizing intercellular trafficking of cGMP in real-time in live follicles from mice expressing a FRET sensor, we show that diffusion of cGMP through gap junctions is responsible not only for maintaining meiotic arrest, but also for rapid transmission of the signal that reinitiates meiosis from the follicle surface to the oocyte. Before LH exposure, the cGMP concentration throughout the follicle is at a uniformly high level of ∼2–4 μM. Then, within 1 min of LH application, cGMP begins to decrease in the peripheral granulosa cells. As a consequence, cGMP from the oocyte diffuses into the sink provided by the large granulosa cell volume, such that by 20 min the cGMP concentration in the follicle is uniformly low, ∼100 nM. The decrease in cGMP in the oocyte relieves the inhibition of the meiotic cell cycle. This direct demonstration that a physiological signal initiated by a stimulus in one region of an intact tissue can travel across many layers of cells via cyclic nucleotide diffusion through gap junctions could provide a general mechanism for diverse cellular processes. PMID:25775542

  7. Direct versus Indirect Treatment for Preschool Children who Stutter: The RESTART Randomized Trial.

    Directory of Open Access Journals (Sweden)

    Caroline de Sonneville-Koedoot

    Full Text Available Stuttering is a common childhood disorder. There is limited high quality evidence regarding options for best treatment. The aim of the study was to compare the effectiveness of direct treatment with indirect treatment in preschool children who stutter.In this multicenter randomized controlled trial with an 18 month follow-up, preschool children who stutter who were referred for treatment were randomized to direct treatment (Lidcombe Program; n = 99 or indirect treatment (RESTART-DCM treatment; n = 100. Main inclusion criteria were age 3-6 years, ≥3% syllables stuttered (%SS, and time since onset ≥6 months. The primary outcome was the percentage of non-stuttering children at 18 months. Secondary outcomes included stuttering frequency (%SS, stuttering severity ratings by the parents and therapist, severity rating by the child, health-related quality of life, emotional and behavioral problems, and speech attitude.Percentage of non-stuttering children for direct treatment was 76.5% (65/85 versus 71.4% (65/91 for indirect treatment (Odds Ratio (OR, 0.6; 95% CI, 0.1-2.4, p = .42. At 3 months, children treated by direct treatment showed a greater decline in %SS (significant interaction time x therapy: β = -1.89; t(282.82 = -2.807, p = .005. At 18 months, stuttering frequency was 1.2% (SD 2.1 for direct treatment and 1.5% (SD 2.1 for indirect treatment. Direct treatment had slightly better scores on most other secondary outcome measures, but no differences between treatment approaches were significant.Direct treatment decreased stuttering more quickly during the first three months of treatment. At 18 months, however, clinical outcomes for direct and indirect treatment were comparable. These results imply that at 18 months post treatment onset, both treatments are roughly equal in treating developmental stuttering in ways that surpass expectations of natural recovery. Follow-up data are needed to confirm these findings in the longer term

  8. Restart Operator Meta-heuristics for a Problem-Oriented Evolutionary Strategies Algorithm in Inverse Mathematical MISO Modelling Problem Solving

    Science.gov (United States)

    Ryzhikov, I. S.; Semenkin, E. S.

    2017-02-01

    This study is focused on solving an inverse mathematical modelling problem for dynamical systems based on observation data and control inputs. The mathematical model is being searched in the form of a linear differential equation, which determines the system with multiple inputs and a single output, and a vector of the initial point coordinates. The described problem is complex and multimodal and for this reason the proposed evolutionary-based optimization technique, which is oriented on a dynamical system identification problem, was applied. To improve its performance an algorithm restart operator was implemented.

  9. Anthrax vaccine adsorbed: further evidence supporting continuing the vaccination series rather than restarting the series when doses are delayed.

    Science.gov (United States)

    Pittman, Phillip R; Cavicchia, M A; Kingsbury, J L; Johnson, N A; Barrera-Oro, J G; Schmader, T; Korman, L; Quinn, X; Ranadive, M

    2014-09-03

    Whether to restart or continue the series when anthrax vaccine doses are missed is a frequent medical management problem. We applied the noninferiority analysis model to this prospective study comparing the Bacillus anthracis protective antigen (PA) IgG antibody response and lethal toxin neutralization activity at day 28 to the anthrax vaccine adsorbed (AVA) (Biothrax®) administered on schedule or delayed. A total of 600 volunteers were enrolled: 354 in the on-schedule cohort; 246 in the delayed cohort. Differences were noted in immune responses between cohorts (panthrax vaccine are delayed as long as 5 or more years.

  10. Analysis of factors associated with hesitation to restart farming after depopulation of animals due to 2010 foot-and-mouth disease epidemic in Japan

    Science.gov (United States)

    KADOWAKI, Hazumu; KAYANO, Taishi; TOBINAGA, Takaharu; TSUTSUMI, Atsuro; WATARI, Michiko; MAKITA, Kohei

    2016-01-01

    An outbreak of foot-and-mouth disease (FMD) occurred in Miyazaki Prefecture, Japan, in 2010. This epidemic was controlled with culling and vaccination, and resulted in the death of nearly 290,000 animals. This paper describes the factors associated with hesitation to restart farming after the epidemic. A questionnaire survey was conducted to assess the mental health of farmers one year after the end of the FMD epidemic in affected areas, and univariate and multivariable analyses were performed. Of 773 farms which had answered the question about restart farming, 55.4% (428/773) had resumed or were planning to resume operation. The farms hesitated restarting were characterized by small scale (P=0.06) and having multiple sources of income (P<0.01). Personal attributes associated with hesitation to restart were advanced age of the owner (P<0.01), with someone with bad physical conditions (P=0.04) and small family size (P<0.01). Factors related to disease control during the epidemic that were associated with hesitation to restart were vaccination of animals (P<0.01), not assisting with culling on other farms (P<0.01), and higher satisfaction with information provided by the government (P=0.02). We found that farmers hesitated to resume farming because they had a limited labor force, had an alternative business or were mentally distressed during disease control. PMID:27149890

  11. Projection methods for the numerical solution of Markov chain models

    Science.gov (United States)

    Saad, Youcef

    1989-01-01

    Projection methods for computing stationary probability distributions for Markov chain models are presented. A general projection method is a method which seeks an approximation from a subspace of small dimension to the original problem. Thus, the original matrix problem of size N is approximated by one of dimension m, typically much smaller than N. A particularly successful class of methods based on this principle is that of Krylov subspace methods which utilize subspaces of the form span(v,av,...,A(exp m-1)v). These methods are effective in solving linear systems and eigenvalue problems (Lanczos, Arnoldi,...) as well as nonlinear equations. They can be combined with more traditional iterative methods such as successive overrelaxation, symmetric successive overrelaxation, or with incomplete factorization methods to enhance convergence.

  12. Monitoring the Restart of a High-Rate Wastewater Disposal Well in the Val d'Agri Oilfield (Italy)

    Science.gov (United States)

    De Gori, P.; Improta, L.; Moretti, M.; Colasanti, G.; Criscuoli, F.

    2015-12-01

    The Val d'Agri Quaternary basin in the Southern Apennine range of Italy hosts the largest inland oil field in Europe. Wastewater coming from the oil exploitation is re-injected by a high-rate disposal well into strongly fractured limestones of the hydrocarbon carbonate reservoir. Disposal activity has induced micro-seismicity since the beginning of injection in June 2006. Around 220 small magnitude events (ML Vulcanologia. The induced micro-seismicity illuminated a pre-existing high-angle fault located 1 km below the well. Since June 2006, wastewater has been re-injected with only short interruptions due acid stimulations. In January 2015 disposal activity was halted due to technical operations in the oil refinery and wastewater injection restarted after two weeks. We installed 5 short-period stations within 10 km of the disposal well to carefully monitor the re-start phase and the subsequent 3 months of disposal activity. This temporary network was complemented by stations of the National Seismic Network giving this final configuration:9 stations within 10 km of the well with the closest station 2 km apart, 13 stations within 20 km. Here we report on the preliminary analysis of the local earthquake recorded during the survey focusing on the events occurred in the injection area. The seismicity rate is compared with injection data.In spite of the dense network, we found that the rate of induced seismicity (both the number and energy of events) is very low when compared to the seismicity recorded during the first 5 years of injection activity carried out with comparable rate and pressure.

  13. Identification of the glycerol kinase gene and its role in diapause embryo restart and early embryo development of Artemia sinica.

    Science.gov (United States)

    Cheng, Cheng; Yao, Feng; Chu, Bing; Li, Xuejie; Liu, Yan; Wu, Yang; Mei, Yanli; Wang, Peisheng; Hou, Lin; Zou, Xiangyang

    2014-03-01

    Glycerol kinase (GK) catalyzes the rate-limiting step in glycerol utilization by transferring a phosphate from ATP to glycerol, yielding glycerol 3-phosphate, which is an important intermediate for both energy metabolism and glycerolipid production. Artemia sinica has an unusual diapause process under stress conditions of high salinity, low temperature and lack of food. In the process, diapause embryos of A. sinica (brine shrimp) accumulate high concentrations of glycerol as a cryoprotectant to prevent low temperature damage to embryos. Upon embryo restart, glycerol is converted into glucose and other carbohydrates. Therefore, GK plays an important role in the diapause embryo restart process. However, the role of GK in diapause termination of embryo development in A. sinica remains unknown. In the present study, a 2096 bp full-length cDNA of gk from A. sinica (As-gk) was obtained, encoding putative 551 amino acids, 60.6 kDa protein. As a crucial enzyme in glycerol uptake and metabolism, GK has been conserved structurally and functionally during evolution. The expression pattern of As-gk was investigated by quantitative real-time PCR and Western blotting. Expression locations of As-gk were analyzed using in situ hybridization. As-gk was widely distributed in the early embryo and several main parts of Artemia after differentiation. The expression of As-GK was also induced by stresses such as cold exposure and high salinity. This initial research into the expression pattern and stress response of GK in Artemia provides a sound basis for further understanding of the function and regulation of genes in early embryonic development in A. sinica and the stress response.

  14. Identification, expression pattern and functional characterization of As-kip2 in diapause embryo restarting process of Artemia sinica.

    Science.gov (United States)

    Zhang, Mengchen; Yao, Feng; Qin, Tong; Hou, Lin; Zou, Xiangyang

    2017-04-15

    Proper control of the cellular processes requires a variety of regulatory proteins that are involved in the cell cycle, proliferation and apoptosis. Cyclin-dependent kinase inhibitor (CKI) negatively regulates transcription and arrests the cell cycle in G1 phase. KIP2 is a member of CKI family, which could inhibit proliferation by tight-binding with several cyclin-CDK complexes. During the embryonic development of the brine shrimp, Artemia sinica, KIP2 plays a key role in the cell cycle regulation, but the specific mechanisms remain unknown. Herein, the 1023bp full-length cDNA of kip2 from A. sinica was cloned. The mRNA expression patterns of As-kip2, As-carp-1 in different development stages and pattern of As-kip2 under environmental stresses were investigated. In situ hybridization of As-kip2 mRNA and immunofluorescence of As-CARP-1 protein showed no tissue or organ specificity. Furthermore, western blotting showed the expressions levels of As-KIP2, As-E2F1, As-p53, As-cyclin E, As-SODD protein, and pattern of As-KIP2 under environmental stresses. Our research revealed that As-KIP2 plays crucial role in the restarting process of diapause embryo in Artemia sinica. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Rebuilding Socio-Economic Cooperation in South East Europe and the Black Sea for Restarting European Integration

    Directory of Open Access Journals (Sweden)

    Grigoris Zarotiadis

    2015-11-01

    Full Text Available In our paper “Feraios Revised: Inter-Regional Trans-National Socioeconomic Cooperation in South and Eastern Europe”, published in International Relations and Diplomacy Journal (December 2014, we analyzed the prospects of an inter-regional cross-national cooperation (in economic, social and political patterns in South and Eastern Europe through the structural reorganization of the existing institutions (local, national or cross-national in the area and we expressed the need for the reintroduction of Rigas Feraios’ perspective of socioeconomic and ultimately of political integration in this region. The present paper is an attempt to explain the reasons why working on the regional socioeconomic cooperation and integration constitutes a necessary condition before going into a wider amalgamation. Contemporary systemic, global crisis brought out internal and transnational aberrations and the fact of the asymmetrical financial integration of the EU countries. The Union consists of a multilevel system were social conflicts, different rates of economic development and various demographic dynamics dominate. The increasing territorial inequalities in the enlarged Europe and the “suspended step” of a monetary unification might establish the need to revert to regional socioeconomic cooperation, on the basis of the existing cultural, economic and historical bonds, like those of South-East Europe and the Black Sea, for restarting European integration and succeed inter-union stability and prosperity.

  16. PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein.

    Science.gov (United States)

    Wessel, Sarah R; Marceau, Aimee H; Massoni, Shawn C; Zhou, Ruobo; Ha, Taekjip; Sandler, Steven J; Keck, James L

    2013-06-14

    Frequent collisions between cellular DNA replication complexes (replisomes) and obstacles such as damaged DNA or frozen protein complexes make DNA replication fork progression surprisingly sporadic. These collisions can lead to the ejection of replisomes prior to completion of replication, which, if left unrepaired, results in bacterial cell death. As such, bacteria have evolved DNA replication restart mechanisms that function to reload replisomes onto abandoned DNA replication forks. Here, we define a direct interaction between PriC, a key Escherichia coli DNA replication restart protein, and the single-stranded DNA-binding protein (SSB), a protein that is ubiquitously associated with DNA replication forks. PriC/SSB complex formation requires evolutionarily conserved residues from both proteins, including a pair of Arg residues from PriC and the C terminus of SSB. In vitro, disruption of the PriC/SSB interface by sequence changes in either protein blocks the first step of DNA replication restart, reloading of the replicative DnaB helicase onto an abandoned replication fork. Consistent with the critical role of PriC/SSB complex formation in DNA replication restart, PriC variants that cannot bind SSB are non-functional in vivo. Single-molecule experiments demonstrate that PriC binding to SSB alters SSB/DNA complexes, exposing single-stranded DNA and creating a platform for other proteins to bind. These data lead to a model in which PriC interaction with SSB remodels SSB/DNA structures at abandoned DNA replication forks to create a DNA structure that is competent for DnaB loading.

  17. Anaerobic treatment of tequila vinasses under seasonal operating conditions: start-up, normal operation and restart-up after a long stop and starvation period.

    Science.gov (United States)

    Jáuregui-Jáuregui, J A; Méndez-Acosta, H O; González-Álvarez, V; Snell-Castro, R; Alcaraz-González, V; Godon, J J

    2014-09-01

    This study examines the performance of an anaerobic fixed-film bioreactor under seasonal operating conditions prevailing in medium and small size Tequila factories: start-up, normal operation and particularly, during the restart-up after a long stop and starvation period. The proposed start-up procedure attained a stable biofilm in a rather short period (28 days) despite unbalanced COD/N/P ratio and the use of non-acclimated inoculum. The bioreactor was restarted-up after being shut down for 6 months during which the inoculum starved. Even when biofilm detachment and bioreactor clogging were detected at the very beginning of restart-up, results show that the bioreactor performed better as higher COD removal and methane yield were attained. CE-SSCP and Q-PCR analyses, conducted on the biofilm prokaryotic communities for each operating condition, confirmed that the high COD removal results after the bioreactor clogging and the severe starvation period were mainly due to the stable archaeal and resilient bacterial populations.

  18. An iterative method for the solution of nonlinear systems using the Faber polynomials for annular sectors

    Energy Technology Data Exchange (ETDEWEB)

    Myers, N.J. [Univ. of Durham (United Kingdom)

    1994-12-31

    The author gives a hybrid method for the iterative solution of linear systems of equations Ax = b, where the matrix (A) is nonsingular, sparse and nonsymmetric. As in a method developed by Starke and Varga the method begins with a number of steps of the Arnoldi method to produce some information on the location of the spectrum of A. This method then switches to an iterative method based on the Faber polynomials for an annular sector placed around these eigenvalue estimates. The Faber polynomials for an annular sector are used because, firstly an annular sector can easily be placed around any eigenvalue estimates bounded away from zero, and secondly the Faber polynomials are known analytically for an annular sector. Finally the author gives three numerical examples, two of which allow comparison with Starke and Varga`s results. The third is an example of a matrix for which many iterative methods would fall, but this method converges.

  19. An iterative method to compute the sign function of a non-Hermitian matrix and its application to the overlap Dirac operator at nonzero chemical potential

    CERN Document Server

    Bloch, J; Lang, B; Wettig, T

    2007-01-01

    The overlap Dirac operator in lattice QCD requires the computation of the sign function of a matrix. While this matrix is usually Hermitian, it becomes non-Hermitian in the presence of a quark chemical potential. We show how the action of the sign function of a non-Hermitian matrix on an arbitrary vector can be computed efficiently on large lattices by an iterative method. A Krylov subspace approximation based on the Arnoldi algorithm is described for the evaluation of a generic matrix function. The efficiency of the method is spoiled when the matrix has eigenvalues close to a function discontinuity. This is cured by adding a small number of critical eigenvectors to the Krylov subspace, for which we propose two different deflation schemes. The ensuing modified Arnoldi method is then applied to the sign function, which has a discontinuity along the imaginary axis. The numerical results clearly show the improved efficiency of the method. Our modification is particularly effective when the action of the sign fun...

  20. Traffic Status Prediction Based on Random Restart Hill-climbing%基于随机重复爬山法的交通状态预测

    Institute of Scientific and Technical Information of China (English)

    钱超; 代亮; 林杉; 李雪

    2016-01-01

    合理构造影响交通状态网络结构,是实现交通状态预测的前提条件。为克服爬山法易陷入局部最优的缺陷,提出一种基于随机重复爬山法的交通状态预测方法。对随机生成的有向无环图迭代运行爬山法得到多网络结构;通过有向边置信度的定义和置信度阈值的计算,确定了最优贝叶斯网络结构中节点和有向边选取准则;利用最优贝叶斯网络结构,实现了畅通、平稳、拥挤和阻塞等4种交通状态的预测并综合评价。分析结果表明,该方法仅选取时段、节假日等两变量时,对交通状态预测总体准确率超过85%,能够为高速公路运行状态监测预警和决策分析提供有效方法和数据支撑。%Construct of reasonable network structure which influencing traffic status is the prerequisite of realizing traffic status prediction. In order to improve Hill-climbing algorithm, which may trap into the local optimum instead of the global optimum, a new traffic status prediction method is proposed based on Random Restart Hill-climbing. Proposed multi-network structures are obtained by executing Hill-climbing algorithm iteratively, to create directed acyclic graphs randomly. Furthermore, selection criterion for nodes and directed edges in the optimal Bayesian network structure is determined by the definition of directed edges-confidence and the calculation of confidence-threshold. The intelligent predictions and comprehensive evaluations of four kinds of traffic status including free, smooth, congestion and jam are achieved by using optimal Bayesian network structure. Results indicate that the prediction results are satisfactory with a high accuracy-rate of more than 85%only selecting two variables such as hour and holiday. Therefore, the proposed method provides an effective way and experimental proof for monitoring, warning and decision analysis of expressway operation status.

  1. Subspace orthogonalization for substructuring preconditioners for nonsymmetric systems of linear equations

    Energy Technology Data Exchange (ETDEWEB)

    Starke, G. [Universitaet Karlsruhe (Germany)

    1994-12-31

    For nonselfadjoint elliptic boundary value problems which are preconditioned by a substructuring method, i.e., nonoverlapping domain decomposition, the author introduces and studies the concept of subspace orthogonalization. In subspace orthogonalization variants of Krylov methods the computation of inner products and vector updates, and the storage of basis elements is restricted to a (presumably small) subspace, in this case the edge and vertex unknowns with respect to the partitioning into subdomains. The author investigates subspace orthogonalization for two specific iterative algorithms, GMRES and the full orthogonalization method (FOM). This is intended to eliminate certain drawbacks of the Arnoldi-based Krylov subspace methods mentioned above. Above all, the length of the Arnoldi recurrences grows linearly with the iteration index which is therefore restricted to the number of basis elements that can be held in memory. Restarts become necessary and this often results in much slower convergence. The subspace orthogonalization methods, in contrast, require the storage of only the edge and vertex unknowns of each basis element which means that one can iterate much longer before restarts become necessary. Moreover, the computation of inner products is also restricted to the edge and vertex points which avoids the disturbance of the computational flow associated with the solution of subdomain problems. The author views subspace orthogonalization as an alternative to restarting or truncating Krylov subspace methods for nonsymmetric linear systems of equations. Instead of shortening the recurrences, one restricts them to a subset of the unknowns which has to be carefully chosen in order to be able to extend this partial solution to the entire space. The author discusses the convergence properties of these iteration schemes and its advantages compared to restarted or truncated versions of Krylov methods applied to the full preconditioned system.

  2. Direct versus indirect treatment for preschool children who stutter: The RESTART randomized trial

    NARCIS (Netherlands)

    C. de Sonneville (Caroline); E.A. Stolk (Elly); Rietveld, T. (Toni); M.-C. Franken (Marie-Christine)

    2015-01-01

    textabstractObjective Stuttering is a common childhood disorder. There is limited high quality evidence regarding options for best treatment. The aim of the study was to compare the effectiveness of direct treatment with indirect treatment in preschool children who stutter. Methods In this multicent

  3. Restarting parallel Jacobi-Davidson with both standard and harmonic Ritz values

    NARCIS (Netherlands)

    M. Nool (Margreet); A. van der Ploeg (Auke)

    1998-01-01

    textabstractWe study the Jacobi-Davidson method for the solution of large generalized eigenproblems as they arise in MagnetoHydroDynamics. We have combined Jacobi-Davidson (using standard Ritz values) with a shift and invert technique. We apply a complete LU decomposition in which reordering

  4. Direct versus indirect treatment for preschool children who stutter: The RESTART randomized trial

    NARCIS (Netherlands)

    C. de Sonneville (Caroline); E.A. Stolk (Elly); T. Rietveld (Toni); M.-C. Franken (Marie-Christine)

    2015-01-01

    textabstractObjective Stuttering is a common childhood disorder. There is limited high quality evidence regarding options for best treatment. The aim of the study was to compare the effectiveness of direct treatment with indirect treatment in preschool children who stutter. Methods In this

  5. Operational readiness verification, phase 1: A study on safety during outage and restart of nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Hollnagel, E. [Linkoeping Univ. (Sweden). Dept. of Computer and Information Science; Gauthereau, V. [Linkoeping Univ. (Sweden). Dept. of Industrial Engineering

    2001-06-01

    This report contains the findings from the first phase of a study on safety during outage and restart of nuclear power plants. Operational Readiness Verification (ORV) - in Swedish called Driftklarhetsverifiering (DKV) - refers to the test and verification activities that are necessary to ensure that plant systems are able to provide their required functions when needed - more concretely that all plant systems are in their correct functional state when the plant is restarted after an outage period. The concrete background for this work is that nine ORV related incidents were reported in Sweden between July 1995 and October 1998. The work reported here comprised a literature survey of research relevant for ORV issues, and an assessment of the present situation at Swedish NPPs with respect to ORV. The literature survey was primarily aimed at research related to NPPs, but also looked at domains where similar problems have occurred, such as maintenance in commercial aviation. The survey looked specifically for organisational and MTO aspects relevant to the present situation in Swedish NPPs. One finding was that ORV should be seen as an integral part of maintenance, rather than as a separate activity. Another, that there is a characteristic distribution of error modes for maintenance and ORV, with many sequence errors and omissions, rather than a set of unique error modes. An international study further showed that there are important differences in how procedures are used, and in the balance between decentralisation and centralisation. Several studies also suggested that ORV could usefully be described as a barrier system in relation to the flow of work, for instance using the following five stages: (1) preventive actions during maintenance/outage, (2) post-test after completion of work, (3) pre-test before start-up, (4) the start-up sequence itself, and (5) preventive actions during power operation - possibly including automatic safety systems. In the field survey

  6. Analysis of the Hydrologic Response Associated with Shutdown and Restart of the 200-ZP-1 Pump-and-Treat System

    Energy Technology Data Exchange (ETDEWEB)

    Spane, Frank A.; Thorne, Paul D.

    2000-09-08

    A number of programs have been implemented on the Hanford Site that utilize the pumping and treatment of contaminated groundwater as part of their remediation strategy. Often the treated water is reinjected into the aquifer at injection well sites. The implementation of remedial pump and treat systems, however, results in hydraulic pressure responses, both areally and vertically (i.e., with depth) within the pumped aquifer. The area within the aquifer affected by the pump and treat system (i.e., radius of influence) is commonly estimated based on detecting associated water-level responses within surrounding monitor wells. Natural external stresses, such as barometric pressure fluctuations, however, can have a discernible impact on well water-level measurements. These temporal barometric effects may significantly mask water-level responses within more distant wells that are only slightly affected (< 0.10 m) by the test system. External stress effects, therefore, can lead to erroneous indications of the radius of influence of the imposed pump and treat system remediation activities and can greatly diminish the ability to analyze the associated well responses for hydraulic property characterization. When these extraneous influences are significant, adjustments or removal of the barometric effects from the test-response record may be required for quantitative hydrologic assessment. This report examines possible hydrologic effects of pump and treat remediation actions and provides a detailed analysis of water-level measurements for selected 200-ZP-1 pump and treat system monitor wells during the recent Y2K shutdown (December 1999) and restart activity (January 2000). The general findings presented in this report have universal application for unconfined and confined aquifer systems.

  7. An iterative method to compute the overlap Dirac operator at nonzero chemical potential

    CERN Document Server

    Bloch, J; Lang, B; Wettig, T

    2007-01-01

    The overlap Dirac operator at nonzero quark chemical potential involves the computation of the sign function of a non-Hermitian matrix. In this talk we present an iterative method, first proposed by us in Ref. [1], which allows for an efficient computation of the operator, even on large lattices. The starting point is a Krylov subspace approximation, based on the Arnoldi algorithm, for the evaluation of a generic matrix function. The efficiency of this method is spoiled when the matrix has eigenvalues close to a function discontinuity. To cure this, a small number of critical eigenvectors are added to the Krylov subspace, and two different deflation schemes are proposed in this augmented subspace. The ensuing method is then applied to the sign function of the overlap Dirac operator, for two different lattice sizes. The sign function has a discontinuity along the imaginary axis, and the numerical results show how deflation dramatically improves the efficiency of the method.

  8. Poincaré recurrences and Ulam method for the Chirikov standard map

    Science.gov (United States)

    Frahm, K. M.; Shepelyansky, D. L.

    2013-07-01

    We study numerically the statistics of Poincaré recurrences for the Chirikov standard map and the separatrix map at parameters with a critical golden invariant curve. The properties of recurrences are analyzed with the help of a generalized Ulam method. This method allows us to construct the corresponding Ulam matrix whose spectrum and eigenstates are analyzed by the powerful Arnoldi method. We also develop a new survival Monte Carlo method which allows us to study recurrences on times changing by ten orders of magnitude. We show that the recurrences at long times are determined by trajectory sticking in a vicinity of the critical golden curve and secondary resonance structures. The values of Poincaré exponents of recurrences are determined for the two maps studied. We also discuss the localization properties of eigenstates of the Ulam matrix and their relation with the Poincaré recurrences.

  9. Heat exchanger restart evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, J.M.; Hirst, C.W.; Lentz, T.F.

    1992-02-28

    On December 24, 1991, the K-Reactor was in the shutdown mode with full AC process water flow and full cooling water flow. Safety rod testing was being performed as part of the power ascension testing program. The results of cooling water samples indicated tritium concentrations higher than allowable. Further sampling and testing confirmed a Process Water System to Cooling Water System leak in heat exchanger 4A (HX 4A). The heat exchanger was isolated and the plant shutdown. Heat exchanger 4kA was removed from the plant and moved to C-Area prior to performing examinations and diagnostic testing. This included locating and identifying the leaking tube or tubes, eddy current examination of the leaking tube and a number of adjacent tubes, visually inspecting the leaking tube from both the inside as well as the area surrounding the failure mechanism. In addition ten other tubes that either exhibited eddy current indications or would represent a baseline condition were removed from heat exchanger 4A for metallurgical examination. Additional analysis and review of heat exchanger leakage history was performed to determine if there are any patterns which can be used for predictive purposes. Compensatory actions have been taken to improve the sensitivity and response time to any future events of this type. The results of these actions are summarized herein.

  10. LHC restart 2016

    CERN Multimedia

    CERN Audiovisual production

    2016-01-01

    Footage of first injection of proton beam in the LHC machine, that took place on Friday March 25, 2016, at the injection energy of 450 GeV. Interview to Mike Lamont, head of LHC operations and of Fabiola Gianotti, CERN Director General. General footage of the Cern Control Centre on first beam 2016 day, the LHC machine operators and Engineers in Charge at work, relevant screens summarizing the machine parametres. Views of the LHC tunnel and the 4 main experimental caverns with views of the ATLAS, CMS, ALICE and LHCb detectors. 3 D animations of the CERN accelerator complex, from the Linac, to the PS, SPS and the LHC. VOICE OVER : Alex Brown

  11. Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress.

    Science.gov (United States)

    Leung, Justin Wai-Chung; Ghosal, Gargi; Wang, Wenqi; Shen, Xi; Wang, Jiadong; Li, Lei; Chen, Junjie

    2013-03-01

    Alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a member of the SWI/SNF protein family of DNA-dependent ATPases. It functions as a chromatin remodeler and is classified as an SNF2-like helicase. Here, we showed somatic knock-out of ATRX displayed perturbed S-phase progression as well as hypersensitivity to replication stress. ATRX is recruited to sites of DNA damage, required for efficient checkpoint activation and faithful replication restart. In addition, we identified ATRX as a binding partner of MRE11-RAD50-NBS1 (MRN) complex. Together, these results suggest a non-canonical function of ATRX in guarding genomic stability.

  12. Operational readiness verification, phase 1: A study on safety during outage and restart of nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Hollnagel, E. [Linkoeping Univ. (Sweden). Dept. of Computer and Information Science; Gauthereau, V. [Linkoeping Univ. (Sweden). Dept. of Industrial Engineering

    2001-06-01

    This report contains the findings from the first phase of a study on safety during outage and restart of nuclear power plants. Operational Readiness Verification (ORV) - in Swedish called Driftklarhetsverifiering (DKV) - refers to the test and verification activities that are necessary to ensure that plant systems are able to provide their required functions when needed - more concretely that all plant systems are in their correct functional state when the plant is restarted after an outage period. The concrete background for this work is that nine ORV related incidents were reported in Sweden between July 1995 and October 1998. The work reported here comprised a literature survey of research relevant for ORV issues, and an assessment of the present situation at Swedish NPPs with respect to ORV. The literature survey was primarily aimed at research related to NPPs, but also looked at domains where similar problems have occurred, such as maintenance in commercial aviation. The survey looked specifically for organisational and MTO aspects relevant to the present situation in Swedish NPPs. One finding was that ORV should be seen as an integral part of maintenance, rather than as a separate activity. Another, that there is a characteristic distribution of error modes for maintenance and ORV, with many sequence errors and omissions, rather than a set of unique error modes. An international study further showed that there are important differences in how procedures are used, and in the balance between decentralisation and centralisation. Several studies also suggested that ORV could usefully be described as a barrier system in relation to the flow of work, for instance using the following five stages: (1) preventive actions during maintenance/outage, (2) post-test after completion of work, (3) pre-test before start-up, (4) the start-up sequence itself, and (5) preventive actions during power operation - possibly including automatic safety systems. In the field survey

  13. 精化的二次残量迭代法%A REFINED RESIDUAL ITERATION METHOD

    Institute of Scientific and Technical Information of China (English)

    贾仲孝; 孙玉泉

    2004-01-01

    According to the refined projection principle advocated by Jia[8], we improve the residual iteration method of quadratic eigenvalue problems and propose a refined residual iteration method. We study the restarting issue of the method and develop a practical algorithm. Preliminary numerical examples illustrate the efficiency of the method.

  14. A Polynomial Preconditioned Global CMRH Method for Linear Systems with Multiple Right-Hand Sides

    Directory of Open Access Journals (Sweden)

    Ke Zhang

    2013-01-01

    Full Text Available The restarted global CMRH method (Gl-CMRH(m (Heyouni, 2001 is an attractive method for linear systems with multiple right-hand sides. However, Gl-CMRH(m may converge slowly or even stagnate due to a limited Krylov subspace. To ameliorate this drawback, a polynomial preconditioned variant of Gl-CMRH(m is presented. We give a theoretical result for the square case that assures that the number of restarts can be reduced with increasing values of the polynomial degree. Numerical experiments from real applications are used to validate the effectiveness of the proposed method.

  15. IPO重启首日超额收益实证研究%Restart on the first day IPO returns over Empirical Study

    Institute of Scientific and Technical Information of China (English)

    黄平; 郭晨鸣

    2011-01-01

    重启之后的中国证券市场,是否能有效地消除各种弊端,抑制首日超额收益过高等异常现象?文章选取我国IPO重启以后发行的新股作为样本,从信息的不对称、承销商的声誉、我国特殊的新股发行制度以及我国投资者的情绪四个角度对我国IPO重启首日超额收益现象进行实证分析,并力图从一级市场发行价格确定和二级市场交易价格形成两个环节来解释我国的IPO首日超额收益,提出一些建设性的参考意见,促进我国的上市公司对IPO进行合理定价,优化资本市场资源的配置。%Chinese stock market after the restart,it can effectively eliminate all the disadvantages of the first day of inhibiting abnormal excess return is too high? This selection of new shares after the IPO to restart as the sample,from the information asymmetry,underwriter reputation,IPO of a special system and the four perspectives of investor sentiment on the restart on the first day of IPO proceeds over the phenomenon of an empirical analysis and trying to determine the issue price from the primary market and secondary market trading price formation to explain two aspects of the first day of the IPO excess returns,then a reference to some constructive advice,and promote China's listed companies to make reasonable IPO pricing,optimize the capital market allocation of resources.

  16. The ISRN has stated on the CABRI reactor restarting; L'IRSN a donne son avis sur le redemarrage du reacteur CABRI

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This paper presents the different issues examined by the ISRN (the French Institute of Radioprotection and Nuclear Safety) for the restarting of the pool type research CABRI reactor which is briefly described in appendix. These issues are: the design, realisation and monitoring of the new pressurised water test loop, the reassessment of the protection system limiting the reactivity injection during tests, inspection of fuel pencil condition, reassessment of safety studies, inspection of the condition of existing equipment which are essential for safety, reassessment of the seismic risk and of the fire risk, reassessment of operation conditions (personal radioprotection, human and organisational factors). An appendix contains the report by the Permanent Group of Experts for Nuclear Reactors with its recommendations.

  17. Terminal-shock and restart control of a Mach 2.5, axisymmetric, mixed compression inlet with 40 percent internal contraction. [wind tunnel tests

    Science.gov (United States)

    Baumbick, R. J.

    1974-01-01

    Results of experimental tests conducted on a supersonic, mixed-compression, axisymmetric inlet are presented. The inlet is designed for operation at Mach 2.5 with a turbofan engine (TF-30). The inlet was coupled to either a choked orifice plate or a long duct which had a variable-area choked exit plug. Closed-loop frequency responses of selected diffuser static pressures used in the terminal-shock control system are presented. Results are shown for Mach 2.5 conditions with the inlet coupled to either the choked orifice plate or the long duct. Inlet unstart-restart traces are also presented. High-response inlet bypass doors were used to generate an internal disturbance and also to achieve terminal-shock control.

  18. Improvements made to the Bruce A upgraders and heavy water cleanup system as part of the Bruce A Units 1 and 2 restart project and commissioning results

    Energy Technology Data Exchange (ETDEWEB)

    Davloor, R., E-mail: ram.davloor@brucepower.com [Bruce Power, Tiverton, Ontario (Canada); Steinberg, G.; Boddy, C. [SNC Lavalin Nuclear, Oakville, Ontario (Canada); Rocci, D. [Aecon Nuclear, Cambridge, Ontario (Canada)

    2013-07-01

    As part of the Bruce A Units 1 and 2 Restart Project, major modifications and maintenance were completed on the heat transport and moderator upgraders and the heavy water cleanup system. This represents the first time that major rehabilitation has been done to such systems in a CANDU nuclear station for the purpose of life extension. Prior to shutdown in 1997, the upgraders and cleanup system significantly underperformed against the stated design. The rehabilitation, which included major design changes and implementation of new systems, resulted in the upgraders exceeding design throughput and making product with quality much better than specified. This paper describes the work done, results from inspections and follow-up, and performance data from commissioning. (author)

  19. Trajectory Scheduling Methods for minimizing total tardiness in a flowshop

    Directory of Open Access Journals (Sweden)

    Xiaoping Li

    2015-12-01

    Full Text Available In this paper, Trajectory Scheduling Methods (TSMs are proposed for the permutation flowshop scheduling problem with total tardiness minimization criterion. TSMs belong to an iterative local search framework, in which local search is performed on an initial solution, a perturbation operator is deployed to improve diversification, and a restart point mechanism is used to select the new start point of another cycle. In terms of the insertion and swap neighborhood structures, six composite heuristics are introduced, which exploit the search space with a strong intensification effect. Based on purely insertion-based or swap-based perturbation structures, three compound perturbation structures are developed that construct a candidate restart point set rather than just a single restart point. The distance between the current best solution and each start point of the set is defined, according to which the diversification effect of TSMs can be boosted by choosing the most appropriate restart point for the next iteration. A total of 18 trajectory scheduling methods are constructed by different combinations of composite heuristics. Both the best and worst combinations are compared with three best existing sequential meta-heuristics for the considered problem on 540 benchmark instances. Experimental results show that the proposed heuristics significantly outperform the three best existing algorithms within the same computation time.

  20. Krylov subspace methods and the sign function: multishifts and deflation in the non-Hermitian case

    CERN Document Server

    Bloch, Jacques C R; Frommer, Andreas; Heybrock, Simon; Schäfer, Katrin; Wettig, Tilo

    2009-01-01

    Rational approximations of the matrix sign function lead to multishift methods. For non-Hermitian matrices long recurrences can cause storage problems, which can be circumvented with restarts. Together with deflation we obtain efficient iterative methods, as we show in numerical experiments for the overlap Dirac operator at non-vanishing quark chemical potential for lattices up to size 10^4.

  1. 水源水生物处理系统启动与再启动过程的硝化性能%Nitrification during Startup and Restart of Biological System for Treatment of Source Water

    Institute of Scientific and Technical Information of China (English)

    梅翔; 高廷耀

    2000-01-01

    On the basis of the pilot-scale experiment, the nitrification performances of startup and restart of the biological contact oxidation system for treating slightly polluted source water have been investigated. The factors affecting startup of the treatment system have been studied, and ammonia-nitrogen removal performances between startup and restart have been compared. The research results showed that the rise rate of ammonia-nitrogen removal amount approximately reflected the logarithmic growth rate of nitrifying bacteria during startup and restart, and the rise rate of ammonia-nitrogen removal amount was the important measurement of startup and restart progresses. The duration of startup and restart was affected by water temperature, and the ammonia-nitrogen nitrification capacity achieved by the treatment system was affected by the air-water ratio. When the packing materials with grown biofilm was submerged in water, the adaptation period of nitrifying bacteria during restart was shorter than that during startup with biofilm formation on the new packing materials.%基于中试规模试验,考察了微污染水源水生物接触氧化处理系统启动与再启动过程的硝化性能,探讨了处理系统启动过程的影响因素,比较了启动与再启动过程的氨氮去除效果。研究结果表明,氨氮去除量上升速率近似反映了启动与再启动过程硝化细菌的对数增长速率,是启动与再启动进程的重要量度;水温影响启动与再启动过程所需的时间,气水比影响处理系统可达到的氨氮硝化能力;保持长有成熟生物膜的填料浸没于水中,再启动过程较新填料挂膜的启动过程硝化细菌适应期短。

  2. Restarting Anticoagulant Treatment After Intracranial Hemorrhage in Patients With Atrial Fibrillation and the Impact on Recurrent Stroke, Mortality, and Bleeding: A Nationwide Cohort Study.

    Science.gov (United States)

    Nielsen, Peter Brønnum; Larsen, Torben Bjerregaard; Skjøth, Flemming; Gorst-Rasmussen, Anders; Rasmussen, Lars Hvilsted; Lip, Gregory Y H

    2015-08-11

    Intracranial hemorrhage is the most feared complication of oral anticoagulant treatment. The optimal treatment option for patients with atrial fibrillation who survive an intracranial hemorrhage remains unknown. We hypothesized that restarting oral anticoagulant treatment was associated with a lower risk of stroke and mortality in comparison with not restarting. Linkage of 3 Danish nationwide registries in the period between 1997 and 2013 identified patients with atrial fibrillation on oral anticoagulant treatment with incident intracranial hemorrhage. Patients were stratified by treatment regimens (no treatment, oral anticoagulant treatment, or antiplatelet therapy) after the intracranial hemorrhage. Event rates were assessed 6 weeks after hospital discharge and compared with Cox proportional hazard models. In 1752 patients (1 year of follow-up), the rate of ischemic stroke/systemic embolism and all-cause mortality (per 100 person-years) for patients treated with oral anticoagulants was 13.6, in comparison with 27.3 for nontreated patients and 25.7 for patients receiving antiplatelet therapy. The rate of ischemic stroke/systemic embolism and all-cause mortality (per 100 person-years) for recurrent intracranial hemorrhage, the rate of ischemic stroke/systemic embolism, and all-cause mortality (per 100 person-years) patients treated with oral anticoagulants was 8.0, in comparison with 8.6 for nontreated patients and 5.3 for patients receiving antiplatelet therapy. The adjusted hazard ratio of ischemic stroke/systemic embolism and all-cause mortality was 0.55 (95% confidence interval, 0.39-0.78) in patients on oral anticoagulant treatment in comparison with no treatment. For ischemic stroke/systemic embolism and for all-cause mortality, hazard ratios were 0.59 (95% confidence interval, 0.33-1.03) and 0.55 (95% confidence interval, 0.37-0.82), respectively. Oral anticoagulant treatment was associated with a significant reduction in ischemic stroke/all-cause mortality

  3. Runge-Kutta methods with minimum storage implementations

    KAUST Repository

    Ketcheson, David I.

    2010-03-01

    Solution of partial differential equations by the method of lines requires the integration of large numbers of ordinary differential equations (ODEs). In such computations, storage requirements are typically one of the main considerations, especially if a high order ODE solver is required. We investigate Runge-Kutta methods that require only two storage locations per ODE. Existing methods of this type require additional memory if an error estimate or the ability to restart a step is required. We present a new, more general class of methods that provide error estimates and/or the ability to restart a step while still employing the minimum possible number of memory registers. Examples of such methods are found to have good properties. © 2009 Elsevier Inc. All rights reserved.

  4. A numerical method for eigenvalue problems in modeling liquid crystals

    Energy Technology Data Exchange (ETDEWEB)

    Baglama, J.; Farrell, P.A.; Reichel, L.; Ruttan, A. [Kent State Univ., OH (United States); Calvetti, D. [Stevens Inst. of Technology, Hoboken, NJ (United States)

    1996-12-31

    Equilibrium configurations of liquid crystals in finite containments are minimizers of the thermodynamic free energy of the system. It is important to be able to track the equilibrium configurations as the temperature of the liquid crystals decreases. The path of the minimal energy configuration at bifurcation points can be computed from the null space of a large sparse symmetric matrix. We describe a new variant of the implicitly restarted Lanczos method that is well suited for the computation of extreme eigenvalues of a large sparse symmetric matrix, and we use this method to determine the desired null space. Our implicitly restarted Lanczos method determines adoptively a polynomial filter by using Leja shifts, and does not require factorization of the matrix. The storage requirement of the method is small, and this makes it attractive to use for the present application.

  5. Some observations on weighted GMRES

    KAUST Repository

    Güttel, Stefan

    2014-01-10

    We investigate the convergence of the weighted GMRES method for solving linear systems. Two different weighting variants are compared with unweighted GMRES for three model problems, giving a phenomenological explanation of cases where weighting improves convergence, and a case where weighting has no effect on the convergence. We also present a new alternative implementation of the weighted Arnoldi algorithm which under known circumstances will be favourable in terms of computational complexity. These implementations of weighted GMRES are compared for a large number of examples. We find that weighted GMRES may outperform unweighted GMRES for some problems, but more often this method is not competitive with other Krylov subspace methods like GMRES with deflated restarting or BICGSTAB, in particular when a preconditioner is used. © 2014 Springer Science+Business Media New York.

  6. Intensity-only imaging with waves, restarted inverse Born series, and analysis of coarsening in polycrystalline materials

    Science.gov (United States)

    Bardsley, Patrick

    We first study the inverse problem of recovering a complex Schrodinger potential from a discrete set of measurements of the solution to the Schrodinger equation using different source terms. We solve this problem by generalizing the inverse Born series method to nonlinear mappings between Banach spaces. In this general setting, we show convergence and stability of inverse Born series follow from a single problem-specific bound. We show this bound for the inverse Schrodinger problem, and study numerically an application of this inverse problem to transient hydraulic tomography. Additionally, we develop a family of iterative methods based on truncated inverse Born series that are akin to iterative methods based on truncated Taylor series. Next, we study the inverse problem of imaging scatterers in a homogeneous medium when only intensities of wavefields can be measured. Classic imaging methods, such as Kirchhoff migration, rely on phase information contained in full waveform data and thus cannot be used directly with intensity-only data. In situations where scattered wavefields are small compared to the incident wavefields, we can form and solve a linear least squares problem to recover a projection (on a known subspace) of full waveform data from intensity data. We show that for sufficiently high frequencies, this projection gives a Kirchhoff image asymptotically equivalent to the Kirchhoff image obtained from full waveform data. We also generalize this imaging method to using stochastic incident fields with autocorrelation measurements. Finally, we study a mathematical model of grain growth in polycrystalline materials. We review a simplified 1D grain growth model and an entropy-based theory for the evolution of an important statistic harvested from this model, the GBCD. The theory suggests the GBCD evolves according to a Fokker-Planck equation, which we validate numerically. We derive methods to estimate times from the GBCD, thus fitting it to Fokker-Planck time

  7. Solution for Speed Sensorless Control System Restarting at Unknown Speed of Traction Motor%牵引电动机无速度传感器带速重投解决方案

    Institute of Scientific and Technical Information of China (English)

    熊成林; 冯晓云; 宋文胜

    2012-01-01

    为了解决无速度传感器交流牵引传动系统带速重投问题,在分析列车运行状态及牵引电机带速重投问题产生原因的基础上,提出了在列车正常运行中利用再生发电状态取代惰行工况的解决方案,并利用Matlab/Simulink仿真验证了该方法的有效性.以动车组CRH3和电力机车HXD3的参数为例,计算了该方案对列车速度和运行时分的影响.研究结果表明,相对于惰行过电分相,该方法对速度大于200 km/h的动车组造成的速度损失和时间损失均小于2%;对速度大于60 km/h的重载货运列车造成的速度损失和时间损失均小于7%.%In order to solve the problem that a traction motor may restart at unknown speed when a speed sensorless control system is applied in electric traction drives, a new strategy using regenerative mode to replace coasting mode is presented on the basis of analyzing the trains operating state and the root causes of this problem, and the effectiveness of this method is verified by numerical simulation using Matlab/Simulink. Taking the parameters of the electric multiple unit (EMU) CRH3 and the electric locomotive HXD3 for example, the influence of this strategy on speed and running time of the motor train is calculated. The results show that compared with those of passing the phase insulator under coasting mode, the loss in both of speed and running time is less than 2% for the EMU running at a speed more than 200 km/h, and less than 7% for heavy haul freight train running at more than 60 km/h.

  8. The Prospects for Nuclear Power Construction after the Restart of Nuclear Power%核电重启后我国核电建设前景分析

    Institute of Scientific and Technical Information of China (English)

    熊伟

    2014-01-01

    With the progress of society, ecological environment is becoming worse and worse, and the clean energy is becoming more and more important. As a kind of efficient clean energy, nuclear power plays an irreplaceable role in the worldwide energy and power development. This essay comprehensively illustrates the importance of nuclear power development to national economic construction and the necessity of energy structure adjustment as well. With a batch of nuclear plant projects permitted on NPC and CPPCC, the nuclear power industry development in our country is restarted at a substantive stage. Under the present circumstances, the prospects for nuclear power development in our country are analyzed in the paper.%随着社会发展和生态环境日益恶化,清洁能源的地位日益凸现。核电是高效、稳定的清洁能源,是世界能源和电力发展不可或缺的一部分。本文综合分析了核电能源的竞争力,我国核电发展现状,以及核电发展对我国能源结构调整的重要性。随着今年两会报告中明确开工建设一批核电项目,我国核电建设步入实质性重启阶段,在此基础上本文最后对我国核电发展规模进行展望。

  9. Restart of circulation of gelled drilling fluids; Estudo do inicio da recirculacao de fluidos de perfuracao gelificados

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Gabriel M. de [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, PR (Brazil); Rocha, Leandro L.V. da; Franco, Admilson T.; Negrao, Cezar O.R. [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, PR (Brazil). Programa de Pos Graduacao em Engenharia Mecanica e de Materiais; Martins, Andre L. [PETROBRAS, Rio de Janeiro, RJ (Brazil). Centro de Pesquisas (CENPES)

    2008-07-01

    This paper describes a mathematical model that simulates the start-up flow of gelled drilling fluids in annular spaces with the purpose to predict pressure peaks at the beginning of the flow. The model comprises the one-dimensional conservation equations of mass and momentum, which are discretized by Finite Volume Method. Fully implicit and up-wind discretization schemes are used and the resultant algebraic equations are solved iteratively by developing a FORTRAN algorithm. The model has the potentiality to be easily adapted to a flow inside a tube. Cases studies are conducted to evaluate the temporal variation of velocity and pressure fields inside both the annular space and a tube. One observed that increasing fluid compressibility or viscosity leads to a reduction of the pressure peaks. (author)

  10. Restarting and recentering genetic algorithm variations for DNA fragment assembly: The necessity of a multi-strategy approach.

    Science.gov (United States)

    Hughes, James Alexander; Houghten, Sheridan; Ashlock, Daniel

    2016-12-01

    DNA Fragment assembly - an NP-Hard problem - is one of the major steps in of DNA sequencing. Multiple strategies have been used for this problem, including greedy graph-based algorithms, deBruijn graphs, and the overlap-layout-consensus approach. This study focuses on the overlap-layout-consensus approach. Heuristics and computational intelligence methods are combined to exploit their respective benefits. These algorithm combinations were able to produce high quality results surpassing the best results obtained by a number of competitive algorithms specially designed and tuned for this problem on thirteen of sixteen popular benchmarks. This work also reinforces the necessity of using multiple search strategies as it is clearly observed that algorithm performance is dependent on problem instance; without a deeper look into many searches, top solutions could be missed entirely. Copyright © 2016. Published by Elsevier Ireland Ltd.

  11. Mauritania : Restarting the Reform Program

    OpenAIRE

    World Bank

    2010-01-01

    Even though Mauritania's real Gross Domestic Product (GDP) recorded an average growth rate of 4 percent between 2005 and 2009, the country's economic growth remains unstable and vulnerable to external shocks. At the same time, the distribution of profits through benefit sharing continues to be very unequal. Since Mauritania's independence in November 28, 1960, it has experienced several pe...

  12. Restartable High Power Gas Generator.

    Science.gov (United States)

    1982-12-01

    or other data, is not to be re- :arded by implication or otherwise as in any manner licensing the holder or any other person or corporation , or...test 13 and 14. The bonding material used for all previous tests was phenolic resin. The Dow Corning adhesive is known to be less comnatible with liauid

  13. ON THE BREAKDOWNS OF THE GALERKIN AND LEAST-SQUARES METHODS

    Institute of Scientific and Technical Information of China (English)

    钟宝江

    2002-01-01

    The Galerkin and least-squares methods are two classes of the most popular Krylovsubspace methOds for solving large linear systems of equations. Unfortunately, both the methodsmay suffer from serious breakdowns of the same type: In a breakdown situation the Galerkinmethod is unable to calculate an approximate solution, while the least-squares method, althoughdoes not really break down, is unsucessful in reducing the norm of its residual. In this paper wefrst establish a unified theorem which gives a relationship between breakdowns in the two meth-ods. We further illustrate theoretically and experimentally that if the coefficient matrix of alienar system is of high defectiveness with the associated eigenvalues less than 1, then the restart-ed Galerkin and least-squares methods will be in great risks of complete breakdowns. It appearsthat our findings may help to understand phenomena observed practically and to derive treat-ments for breakdowns of this type.

  14. A highly scalable massively parallel fast marching method for the Eikonal equation

    CERN Document Server

    Yang, Jianming

    2015-01-01

    In this study, we present a highly scalable massively parallel implementation of the fast marching method using a domain decomposition approach. Central to this algorithm is a novel restarted narrow band approach that coordinates the frequency of communications and the amount of computations extra to a sequential run for achieving an unprecedented parallel performance. Within each restart, the narrow band fast marching method is executed; simple synchronous local exchanges and global reductions are adopted for communicating updated data in the overlapping regions between neighboring subdomains and getting the latest front status, respectively. The independence of front characteristics is exploited through special data structures and augmented status tags to extract the masked parallelism within the fast marching method. The efficiency, flexibility, and applicability of the parallel algorithm are demonstrated through several examples. These problems are extensively tested on grids with up to 1 billion points u...

  15. A LANCZOS METHOD AND A REFINED LANCZOS METHOD FOR LARGE UNSYMMETRIC LINEAR SYSTEMS%解大规模非对称线性方程组的Lanczos方法和精化Lanczos方法

    Institute of Scientific and Technical Information of China (English)

    贾仲孝; 李焱淼

    2004-01-01

    A large unsymmetric linear system problem is transformed into the problem of computing the eigenvector of a large symmetric nonnegative definite matrix associated with the eigenvalue zero, i.e., the computation of the elgenvector of the cross-product matrix of an augmented matrix associated with the eigenvalue zero. The standard Lanczos method and an improved refined Lanczos method are proposed that compute approximate eigenvectors and return approximate solutions of the linear system. An implicitly restarted Lanczos algorithm and its refined version are developed. Theoretical analysis and numerical experiments show the refined method is better than the standard one. If the large matrix has small eigenvalues, the two new algorithms are much faster than the unpreconditioned restarted GMRES.

  16. method

    Directory of Open Access Journals (Sweden)

    L. M. Kimball

    2002-01-01

    Full Text Available This paper presents an interior point algorithm to solve the multiperiod hydrothermal economic dispatch (HTED. The multiperiod HTED is a large scale nonlinear programming problem. Various optimization methods have been applied to the multiperiod HTED, but most neglect important network characteristics or require decomposition into thermal and hydro subproblems. The algorithm described here exploits the special bordered block diagonal structure and sparsity of the Newton system for the first order necessary conditions to result in a fast efficient algorithm that can account for all network aspects. Applying this new algorithm challenges a conventional method for the use of available hydro resources known as the peak shaving heuristic.

  17. An efficient exponential time integration method for the numerical solution of the shallow water equations on the sphere

    Science.gov (United States)

    Gaudreault, Stéphane; Pudykiewicz, Janusz A.

    2016-10-01

    The exponential propagation methods were applied in the past for accurate integration of the shallow water equations on the sphere. Despite obvious advantages related to the exact solution of the linear part of the system, their use for the solution of practical problems in geophysics has been limited because efficiency of the traditional algorithm for evaluating the exponential of Jacobian matrix is inadequate. In order to circumvent this limitation, we modify the existing scheme by using the Incomplete Orthogonalization Method instead of the Arnoldi iteration. We also propose a simple strategy to determine the initial size of the Krylov space using information from previous time instants. This strategy is ideally suited for the integration of fluid equations where the structure of the system Jacobian does not change rapidly between the subsequent time steps. A series of standard numerical tests performed with the shallow water model on a geodesic icosahedral grid shows that the new scheme achieves efficiency comparable to the semi-implicit methods. This fact, combined with the accuracy and the mass conservation of the exponential propagation scheme, makes the presented method a good candidate for solving many practical problems, including numerical weather prediction.

  18. Method

    Directory of Open Access Journals (Sweden)

    Xixin Wang

    2012-01-01

    Full Text Available ZrO2 nanotube arrays were prepared by anodization method in aqueous electrolyte containing (NH42SO4 and NH4F. The morphology and structure of nanotube arrays were characterized through scanning electron microscope, X-ray diffraction, and infrared spectra analysis. The zirconia nanotube arrays were used as catalyst in esterification reaction. The effects of calcination temperature and electrolyte concentration on catalytic esterification activity have been investigated in detail. Experiments indicate that nanotube arrays have highest catalytic activity when the concentration of (NH42SO4 is 1 mol/L, the concentration of NH4F is 1 wt%, and the calcination temperature is 400°C. Esterification reaction yield of as much as 97% could be obtained under optimal conditions.

  19. Minimal residual method stronger than polynomial preconditioning

    Energy Technology Data Exchange (ETDEWEB)

    Faber, V.; Joubert, W.; Knill, E. [Los Alamos National Lab., NM (United States)] [and others

    1994-12-31

    Two popular methods for solving symmetric and nonsymmetric systems of equations are the minimal residual method, implemented by algorithms such as GMRES, and polynomial preconditioning methods. In this study results are given on the convergence rates of these methods for various classes of matrices. It is shown that for some matrices, such as normal matrices, the convergence rates for GMRES and for the optimal polynomial preconditioning are the same, and for other matrices such as the upper triangular Toeplitz matrices, it is at least assured that if one method converges then the other must converge. On the other hand, it is shown that matrices exist for which restarted GMRES always converges but any polynomial preconditioning of corresponding degree makes no progress toward the solution for some initial error. The implications of these results for these and other iterative methods are discussed.

  20. Method

    Directory of Open Access Journals (Sweden)

    Andrey Gnatov

    2015-01-01

    Full Text Available Recently repair and recovery vehicle body operations become more and more popular. A special place here is taken by equipment that provides performance of given repair operations. The most interesting things are methods for recovery of car body panels that allow the straightening without disassembling of car body panels and damaging of existing protective coating. Now, there are several technologies for repair and recovery of car body panels without their disassembly and dismantling. The most perspective is magnetic-pulse technology of external noncontact straightening. Basics of magnetic-pulse attraction, both ferromagnetic and nonferromagnetic thin-walled sheet metal, are explored. Inductor system calculation models of magnetic-pulse straightening tools are presented. Final analytical expressions for excited efforts calculation in the tools under consideration are introduced. According to the obtained analytical expressions, numerical evaluations of excited forces were executed. The volumetric epures of the attractive force radial distributions for different types of inductors were built. The practical testing of magnetic-pulse straightening with research tools is given. Using the results of the calculations we can create effective tools for an external magnetic-pulse straightening of car body panels.

  1. A new approach to acceleration of methods of creating graphic animation in architecture

    Directory of Open Access Journals (Sweden)

    Radojčić Marko

    2011-01-01

    Full Text Available Modern approach to technical visualization methods is not possible without using contemporary 3D animation methods. Obvious need of demonstrating the results of design process in civil engineering, architecture and other technical areas still includes classical time consuming and non-flexible methods that require the process to restart in case of making some changes on the design. This method proposes changes based on some already available open source software packages and components that can be modified in a manner that unlocks accelerated technical visualizations in real time and with instant modifications along with efficiently usage of the processing power of contemporary graphics processing units.

  2. Restart of the LHC. New physics. The particle physics behind the world machine illustratively explained; Neustart des LHC. Neue Physik. Die Teilchenphysik hinter der Weltmaschine anschaulich erklaert

    Energy Technology Data Exchange (ETDEWEB)

    Knochel, Alexander

    2016-07-01

    The following topics are dealt with: The ascertainment of scientific virgin territory by means of the LHC ar CERN, the study of actual questions of cosmology and astrophysics like dark matter and dark energy by means of the LHC, the presently existing anomalies in the data with regards to new phenomena together with statistical methods for the correct estimation of such observations, the supplement of other experiments for the LHC experiments, the Higgs boson, supersymmetry, higher dimensions, the study of quantum gravity in accelerator experiments with regards to the string theory. (HSI)

  3. Advances in Spectral Methods for UQ in Incompressible Navier-Stokes Equations

    KAUST Repository

    Le Maitre, Olivier

    2014-01-06

    In this talk, I will present two recent contributions to the development of efficient methodologies for uncertainty propagation in the incompressible Navier-Stokes equations. The first one concerns the reduced basis approximation of stochastic steady solutions, using Proper Generalized Decompositions (PGD). An Arnoldi problem is projected to obtain a low dimensional Galerkin problem. The construction then amounts to the resolution of a sequence of uncoupled deterministic Navier-Stokes like problem and simple quadratic stochastic problems, followed by the resolution of a low-dimensional coupled quadratic stochastic problem, with a resulting complexity which has to be contrasted with the dimension of the whole Galerkin problem for classical spectral approaches. An efficient algorithm for the approximation of the stochastic pressure field is also proposed. Computations are presented for uncertain viscosity and forcing term to demonstrate the effectiveness of the reduced method. The second contribution concerns the computation of stochastic periodic solutions to the Navier-Stokes equations. The objective is to circumvent the well-known limitation of spectral methods for long-time integration. We propose to directly determine the stochastic limit-cycles through the definition of its stochastic period and an initial condition over the cycle. A modified Newton method is constructed to compute iteratively both the period and initial conditions. Owing to the periodic character of the solution, and by introducing an appropriate time-scaling, the solution can be approximated using low-degree polynomial expansions with large computational saving as a result. The methodology is illustrated for the von-Karman flow around a cylinder with stochastic inflow conditions.

  4. The LHC restart in one minute

    CERN Multimedia

    2016-01-01

    On Friday March 25 2016, the Large Hadron Collider (LHC) got its first proton beam of the year. In just over 1 minute this time-lapse provides a quick overview to some of the important milestones that preceded proton beam injection this year, against a background of activities over the last few days in the CERN Control Centre (CCC), the place where the CERN accelerator chain is operated and controlled. Read more: http://cern.ch/go/Z9cz Music From FruityAudio, entitled "New Groove". - Producer - Audiovisual production service Paola Catapano - Director - Julien Ordan - Camera - Julien Ordan Maximilien Brice - Graphics \\ Animations - Arzur Catel Torres - Infography - Daniel Dominguez Noemi Caraban - Music - FruityAudio - New groove Category Film & Animation License Standard YouTube License

  5. Electrically heated particulate filter restart strategy

    Science.gov (United States)

    Gonze, Eugene V [Pinckney, MI; Ament, Frank [Troy, MI

    2011-07-12

    A control system that controls regeneration of a particulate filter is provided. The system generally includes a propagation module that estimates a propagation status of combustion of particulate matter in the particulate filter. A regeneration module controls current to the particulate filter to re-initiate regeneration based on the propagation status.

  6. Multi level programming Paradigm for Extreme Computing

    Science.gov (United States)

    Petiton, S.; Sato, M.; Emad, N.; Calvin, C.; Tsuji, M.; Dandouna, M.

    2014-06-01

    Abstract: In order to propose a framework and programming paradigms for post-petascale computing, on the road to exascale computing and beyond, we introduced new languages, associated with a hierarchical multi-level programming paradigm, allowing scientific end-users and developers to program highly hierarchical architectures designed for extreme computing. In this paper, we explain the interest of such hierarchical multi-level programming paradigm for extreme computing and its well adaptation to several large computational science applications, such as for linear algebra solvers used for reactor core physic. We describe the YML language and framework allowing describing graphs of parallel components, which may be developed using PGAS-like language such as XMP, scheduled and computed on supercomputers. Then, we propose experimentations on supercomputers (such as the "K" and "Hooper" ones) of the hybrid method MERAM (Multiple Explicitly Restarted Arnoldi Method) as a case study for iterative methods manipulating sparse matrices, and the block Gauss-Jordan method as a case study for direct method manipulating dense matrices. We conclude proposing evolutions for this programming paradigm.

  7. A highly scalable massively parallel fast marching method for the Eikonal equation

    Science.gov (United States)

    Yang, Jianming; Stern, Frederick

    2017-03-01

    The fast marching method is a widely used numerical method for solving the Eikonal equation arising from a variety of scientific and engineering fields. It is long deemed inherently sequential and an efficient parallel algorithm applicable to large-scale practical applications is not available in the literature. In this study, we present a highly scalable massively parallel implementation of the fast marching method using a domain decomposition approach. Central to this algorithm is a novel restarted narrow band approach that coordinates the frequency of communications and the amount of computations extra to a sequential run for achieving an unprecedented parallel performance. Within each restart, the narrow band fast marching method is executed; simple synchronous local exchanges and global reductions are adopted for communicating updated data in the overlapping regions between neighboring subdomains and getting the latest front status, respectively. The independence of front characteristics is exploited through special data structures and augmented status tags to extract the masked parallelism within the fast marching method. The efficiency, flexibility, and applicability of the parallel algorithm are demonstrated through several examples. These problems are extensively tested on six grids with up to 1 billion points using different numbers of processes ranging from 1 to 65536. Remarkable parallel speedups are achieved using tens of thousands of processes. Detailed pseudo-codes for both the sequential and parallel algorithms are provided to illustrate the simplicity of the parallel implementation and its similarity to the sequential narrow band fast marching algorithm.

  8. A new species of the genus Rossomyrmex Arnoldi, 1928 from Turkey (Hymenoptera. Formicidae

    Directory of Open Access Journals (Sweden)

    Tinaut, A.

    2007-06-01

    Full Text Available A new species, Rossomyrmex anatolicus, is described from the Anatolian plains (Turkey. Although it is very similar to R. proformicarum because of the abundant pilosity, it can be distinguished by the petiole, which gradually narrows towards the apex. This character, together with the high number of hairs, can be used, also, to differentiate it from R. minuchae. The geographical distribution of the genus Rossomyrmex is discussed and compared with other taxa that also show disjointed distributions.Se describe Rossomyrmex anatolicus, nueva especie encontrada en las llanuras de Anatolia (Turquía. Muy parecida a R. proformicarum por la abundante pilosidad, se diferencia de ésta por el peciolo, que se estrecha gradualmente hasta el ápice. Este mismo carácter, junto con la pilosidad permiten diferenciarla de R. minuchae. Se discute la distribución geográfica del género Rossomyrmex y se compara con la de otros taxones que muestran también distribución disjunta.

  9. Convergence estimates for iterative methods via the Kriess Matrix Theorem on a general complex domain

    Energy Technology Data Exchange (ETDEWEB)

    Toh, K.C.; Trefethen, L.N. [Cornell Univ., Ithaca, NY (United States)

    1994-12-31

    What properties of a nonsymmetric matrix A determine the convergence rate of iterations such as GMRES, QMR, and Arnoldi? If A is far from normal, should one replace the usual Ritz values {r_arrow} eigenvalues notion of convergence of Arnoldi by alternative notions such as Arnoldi lemniscates {r_arrow} pseudospectra? Since Krylov subspace iterations can be interpreted as minimization processes involving polynomials of matrices, the answers to questions such as these depend upon mathematical problems of the following kind. Given a polynomial p(z), how can one bound the norm of p(A) in terms of (1) the size of p(z) on various sets in the complex plane, and (2) the locations of the spectrum and pseudospectra of A? This talk reports some progress towards solving these problems. In particular, the authors present theorems that generalize the Kreiss matrix theorem from the unit disk (for the monomial A{sup n}) to a class of general complex domains (for polynomials p(A)).

  10. Solution of Constrained Optimal Control Problems Using Multiple Shooting and ESDIRK Methods

    DEFF Research Database (Denmark)

    Capolei, Andrea; Jørgensen, John Bagterp

    2012-01-01

    In this paper, we describe a novel numerical algorithm for solution of constrained optimal control problems of the Bolza type for stiff and/or unstable systems. The numerical algorithm combines explicit singly diagonally implicit Runge-Kutta (ESDIRK) integration methods with a multiple shooting...... algorithm. As we consider stiff systems, implicit solvers with sensitivity computation capabilities for initial value problems must be used in the multiple shooting algorithm. Traditionally, multi-step methods based on the BDF algorithm have been used for such problems. The main novel contribution...... of this paper is the use of ESDIRK integration methods for solution of the initial value problems and the corresponding sensitivity equations arising in the multiple shooting algorithm. Compared to BDF-methods, ESDIRK-methods are advantageous in multiple shooting algorithms in which restarts and frequent...

  11. RecRWR: a recursive random walk method for improved identification of diseases.

    Science.gov (United States)

    Arrais, Joel Perdiz; Oliveira, José Luís

    2015-01-01

    High-throughput methods such as next-generation sequencing or DNA microarrays lack precision, as they return hundreds of genes for a single disease profile. Several computational methods applied to physical interaction of protein networks have been successfully used in identification of the best disease candidates for each expression profile. An open problem for these methods is the ability to combine and take advantage of the wealth of biomedical data publicly available. We propose an enhanced method to improve selection of the best disease targets for a multilayer biomedical network that integrates PPI data annotated with stable knowledge from OMIM diseases and GO biological processes. We present a comprehensive validation that demonstrates the advantage of the proposed approach, Recursive Random Walk with Restarts (RecRWR). The obtained results outline the superiority of the proposed approach, RecRWR, in identifying disease candidates, especially with high levels of biological noise and benefiting from all data available.

  12. IMPLEMENTATION OF THE IMPROVED QUASI-STATIC METHOD IN RATTLESNAKE/MOOSE FOR TIME-DEPENDENT RADIATION TRANSPORT MODELLING

    Energy Technology Data Exchange (ETDEWEB)

    Zachary M. Prince; Jean C. Ragusa; Yaqi Wang

    2016-02-01

    Because of the recent interest in reactor transient modeling and the restart of the Transient Reactor (TREAT) Facility, there has been a need for more efficient, robust methods in computation frameworks. This is the impetus of implementing the Improved Quasi-Static method (IQS) in the RATTLESNAKE/MOOSE framework. IQS has implemented with CFEM diffusion by factorizing flux into time-dependent amplitude and spacial- and weakly time-dependent shape. The shape evaluation is very similar to a flux diffusion solve and is computed at large (macro) time steps. While the amplitude evaluation is a PRKE solve where the parameters are dependent on the shape and is computed at small (micro) time steps. IQS has been tested with a custom one-dimensional example and the TWIGL ramp benchmark. These examples prove it to be a viable and effective method for highly transient cases. More complex cases are intended to be applied to further test the method and its implementation.

  13. A 2D/1D coupling neutron transport method based on the matrix MOC and NEM methods

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, H.; Zheng, Y.; Wu, H.; Cao, L. [School of Nuclear Science and Technology, Xi' an Jiaotong University, No. 28, Xianning West Road, Xi' an, Shaanxi 710049 (China)

    2013-07-01

    A new 2D/1D coupling method based on the matrix MOC method (MMOC) and nodal expansion method (NEM) is proposed for solving the three-dimensional heterogeneous neutron transport problem. The MMOC method, used for radial two-dimensional calculation, constructs a response matrix between source and flux with only one sweep and then solves the linear system by using the restarted GMRES algorithm instead of the traditional trajectory sweeping process during within-group iteration for angular flux update. Long characteristics are generated by using the customization of commercial software AutoCAD. A one-dimensional diffusion calculation is carried out in the axial direction by employing the NEM method. The 2D and ID solutions are coupled through the transverse leakage items. The 3D CMFD method is used to ensure the global neutron balance and adjust the different convergence properties of the radial and axial solvers. A computational code is developed based on these theories. Two benchmarks are calculated to verify the coupling method and the code. It is observed that the corresponding numerical results agree well with references, which indicates that the new method is capable of solving the 3D heterogeneous neutron transport problem directly. (authors)

  14. DYNAMIC CHARACTERISTIC ANALYSIS OF A 3-D SEMI-SUBMERGED BODY AS A FLUID-STRUCTURE INTERACTION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    徐刚; 任文敏

    2004-01-01

    An Arnoldi's method with new iteration pattern, which was designed for solving a large unsymmetric eigenvalue problem introduced by displacement-pressure FE (Finite Element) pattern of a fluid-structure interaction system, was adopted here to get the dynamic characteristics of the semi-submerged body. The new iteration pattern could be used efficiently to obtain the Arnoldi's vectors in the shift-frequency technique, which was used for the zero-frequency problem. Numerical example showed that the fluid-structure interaction is one of the important factors to the dynamic characteristics of large semi-submerged thin-walled structures.

  15. Collaborative Methods for Real-time Localization in Urban Centers

    Directory of Open Access Journals (Sweden)

    Sébastien Peyraud

    2015-11-01

    Full Text Available This article presents an effective solution for the localization of a vehicle in dense urban areas where GNSS-based methods fail because of poor satellite visibility. It advocates the use of a visual-based method processing georeferenced landmarks obtained after a learning path and stored in a new layer of the geographical information system (GIS used for navigation. Real-time localization gives, with few failures, accurate results in the areas covered by the GIS. The integrity of the localization is obtained by running another algorithm in parallel, processing odometric data combined with the geometric model of the drivable area and, when available, GNSS data in tight coupling. An ellipsoidal confidence domain is updated by using both extended Kalman filtering (EKF and set-membership estimation. Although less accurate, this estimation is reliable and, when the visual method fails, the availability of a confidence domain enables us to speed up the restart of the visual method while navigating cautiously. A large-scale experiment (>4 km was conducted in the centre of Paris. We compare the absolute localization results with the ground truth obtained by combining RTK-GPS and a high-end inertial measurement unit (IMU.

  16. New Thoughts on the Restarting of Chinese Campus Football in the New Situation%新形势下我国校园足球“再出发”的新思考

    Institute of Scientific and Technical Information of China (English)

    刘少强; 阿英嘎

    2016-01-01

    To implement the party's education policy,realize the basic task of khalid ents; promote physical education reform and ensure the benign development of campus football in China,under the leadership of the General Secretary Xi Jinping, a new cam-pus football is promoting again( different from campus football work over the past five years) . By using methods of literature,the paper carefully analyzed the first round football problems in the implementation of activities on campus, campus on the current re-consideration of steady progress made in the implementation of football. Studies suggest that school football start under the new sit-uation:1, be sure of campus soccer education for the final positioning;2, stresses the school football just for a hand of school sports;3, to remove the prejudices of the exam-oriented education on campus football;4, and strive to form a campus football organizations working together. Ensure the campus football has advanced steadily, and eventually achieve the overall objective of school football development.%为贯彻党的教育方针,实现立德树人的根本任务;推动体育教育改革,保证校园足球良性发展。在习近平总书记的亲自带领下,新一轮校园足球工作再次推进(区别于过去五年的校园足球开展工作)。使用文献资料法分析第一轮校园足球活动实施过程中出现的问题,对当下校园足球实施工作的稳步推进做出重新思考。结论认为,新形势下我国校园足球活动实践应做到:1)要明确校园足球育人为本的最终定位;2)强调校园足球只是开展学校体育工作的一个抓手;3)去除应试教育下校园足球的偏见化;4)努力形成校园足球的组织合力。确保我国校园足球能够稳步推进,最终实现校园足球发展的总目标。

  17. Transition risk method and example

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, R.E. [Westinghouse Electric Company, Monroeville PA (United States); Farkas, S.E. [Hudson Global Resources (United States)

    2004-07-01

    Paragraph (a)(4) of the Maintenance Rule (10CFR-50.65) states that before performing maintenance activities, the licensees shall assess and manage the increase in risk that may result from the maintenance activities. Currently, most plants use a qualitative tool for assessing and controlling the risk of the various plant conditions during an outage. Fewer plants have any means of performing a quantitative or qualitative assessment of the associated risks of transitioning the plant in each configuration from power to 'cold shutdown'. Typically, only the end-state of shutdown is considered. Given the concern that the NRC may require quantitative risk assessments of plant transitions and plant configurations during shutdown operations, Omaha Public Power District (OPPD) pro-actively authorized Westinghouse Engineering Services to develop a method for assessing risk associated with a transition from all power to shutdown and back to full power. An outage schedule is highly plant specific. Accordingly, the duration of the transition largely depends on equipment maintenance activities driving the decision to shutdown and repair. The time spent in various parts of the transition is a strong determinant in the associated risk of the transition. A transition takes the plant through a series of Plant Operational States (POSs). The features important to the characterization of each of the POSs include decay-heat level, plant activities involved, available equipment, as well as RCS temperature and pressure. The risk of the entire transition comes from calculating a figure-of-merit of each POS which can be loosely thought of as a per-hour core-damage frequency (CDF). Our paper describes decomposing OPPD operating procedures into periods for which we quantified sequences. In particular, the method considers the dominant shutdown failure modes: loss of shutdown cooling, loss of inventory, and loss of offsite power (including both plant centered and grid-related events

  18. New Understanding of Hubble Space Telescope Gyro Current Increase Led to a Method to Save a Failing Gyro Presentation

    Science.gov (United States)

    Blumenstock, Kenneth A.

    2017-01-01

    Throughout the history of the Hubble Space Telescope (HST) program, gyro current increases have been observed to occur, often times leading to gyro failure. The explanation was that debris from the surfaces of the gas bearings, with only 1.27 micron clearance, resulted in rotor restriction, which increased friction, torque, and current. However, the rotor restriction theory never could account for the fact that a restart of the gyro would restore the current back to nominal. An effort was made to understand this puzzling gyro behavior after two HST gyros exhibited increased current within the same week in November 2015. A review board was created to resolve these anomalies and generate operational procedures to potentially extend gyro life. A new understanding of gyro current behavior led to implementation of a method that could potentially save a failing gyro.

  19. Hitting Restart: Learning and Gaming in an Australian Classroom

    Science.gov (United States)

    Altura, Gerard J.; Curwood, Jen Scott

    2015-01-01

    Research suggests that video games can foster deep engagement, critical thinking, and collaborative learning. To highlight how video games promote student achievement, we focus on a year 9 elective class in Australia. Our findings suggest that this games-based class encouraged student learning and motivated students to develop advanced literacy…

  20. Restart: The Resurgence of Computer Science in UK Schools

    Science.gov (United States)

    Brown, Neil C. C.; Sentance, Sue; Crick, Tom; Humphreys, Simon

    2014-01-01

    Computer science in UK schools is undergoing a remarkable transformation. While the changes are not consistent across each of the four devolved nations of the UK (England, Scotland, Wales and Northern Ireland), there are developments in each that are moving the subject to become mandatory for all pupils from age 5 onwards. In this article, we…

  1. Residual, restarting and Richardson iteration for the matrix exponential

    NARCIS (Netherlands)

    Botchev, M.A.

    2010-01-01

    A well-known problem in computing some matrix functions iteratively is a lack of a clear, commonly accepted residual notion. An important matrix function for which this is the case is the matrix exponential. Assume, the matrix exponential of a given matrix times a given vector has to be computed.

  2. Residual, restarting and Richardson iteration for the matrix exponential

    NARCIS (Netherlands)

    Botchev, Mike A.; Grimm, Volker; Hochbruck, Marlis

    2013-01-01

    A well-known problem in computing some matrix functions iteratively is the lack of a clear, commonly accepted residual notion. An important matrix function for which this is the case is the matrix exponential. Suppose the matrix exponential of a given matrix times a given vector has to be computed.

  3. Restarting life: fertilization and the transition from meiosis to mitosis.

    Science.gov (United States)

    Clift, Dean; Schuh, Melina

    2013-09-01

    Fertilization triggers a complex cellular programme that transforms two highly specialized meiotic germ cells, the oocyte and the sperm, into a totipotent mitotic embryo. Linkages between sister chromatids are remodelled to support the switch from reductional meiotic to equational mitotic divisions; the centrosome, which is absent from the egg, is reintroduced; cell division shifts from being extremely asymmetric to symmetric; genomic imprinting is selectively erased and re-established; and protein expression shifts from translational control to transcriptional control. Recent work has started to reveal how this remarkable transition from meiosis to mitosis is achieved.

  4. The slings and arrows of LHC restart schedules

    CERN Document Server

    2015-01-01

    We should now have been celebrating the first circulating beams of LHC Run 2, but, as I reported last Tuesday, I find myself instead having to write about a delay in proceedings. Against a backdrop of great progress in the powering tests for running at 6.5 TeV, a short to ground in one of the LHC’s thousands of circuits became apparent on 21 March.   Although a simple job to repair, it is compounded by the fact that the short is in a cold section of the machine, and it might therefore require a few weeks to warm up, carry out the repair and cool down again. Nevertheless, all the signs are good for a great Run 2, and in the grand scheme of things, a delay of weeks in humankind’s quest to understand our universe is little more than the blink of an eye. The impact of the delay on the experiments will be minimal, as 2015 was always foreseen as a year for preparing the upgraded machine for full-scale physics running in 2016-2018. When the LHC’s first run got underway...

  5. Restart: The Resurgence of Computer Science in UK Schools

    Science.gov (United States)

    Brown, Neil C. C.; Sentance, Sue; Crick, Tom; Humphreys, Simon

    2014-01-01

    Computer science in UK schools is undergoing a remarkable transformation. While the changes are not consistent across each of the four devolved nations of the UK (England, Scotland, Wales and Northern Ireland), there are developments in each that are moving the subject to become mandatory for all pupils from age 5 onwards. In this article, we…

  6. TIGGERC: Turbomachinery interactive grid generator energy distributor and restart code

    Science.gov (United States)

    Miller, David P.

    1992-01-01

    A two dimensional multi-block grid generator was developed for a new design and analysis system for studying multi-blade row turbomachinery problems with an axisymmetric viscous/inviscid 'average passage' through flow code. TIGGERC is a mouse driven, fully interactive grid generation program which can be used to modify boundary coordinates and grid packing. TIGGERC generates grids using a hyperbolic tangent or algebraic distribution of grid points on the block boundaries and the interior points of each block grid are distributed using a transfinite interpolation approach. TIGGERC generates a blocked axisymmetric H grid, C grid, I grid, or O grid for studying turbomachinery flow problems. TIGGERC was developed for operation on small high speed graphic workstations.

  7. A stop-restart solid propellant study with salt quench

    Science.gov (United States)

    Kumar, R. N.

    1976-01-01

    Experiments were conducted to gain insight into the unsatisfactory performance of the salt quench system of solid propellants in earlier studies. Nine open-air salt spray tests were conducted and high-speed cinematographic coverage was obtained of the events. It is shown that the salt spray by the detonator is generally a two-step process yielding two different fractions. The first fraction consists of finely powdered salt and moves practically unidirectionally at a high velocity (thousand of feet per second) while the second fraction consists of coarse particles and moves randomly at a low velocity (a few feet per second). Further investigation is required to verify the speculation that a lower quench charge ratio (weight of salt/propellant burning area) than previously employed may lead to an efficient quench

  8. Restart of theory of air-breathing engines

    Science.gov (United States)

    Rester, Austin

    1992-07-01

    Expansion and compression ratios are treated as independent variables in the derivation of new equations for thermal efficiencies. A conceptual process of isentropic compression of exhaust gases to ambient conditions simplifies the equations for piston engines. Expansion is shown to govern thermal efficiency. A variable-process piston engine is introduced in this paper. Relative to 1/2 load conditions, this new engine is 25 percent more efficient than an Otto engine. Relative to full load, the new engine is 35 percent more powerful than a naturally-aspirated Otto engine. New energy-efficient gas turbines and turbo-jets which utilize pulse-combustion to maximize expansion of combustion gases are also introduced.

  9. More bad connections may limit LHC energy or delay restart

    CERN Multimedia

    Cho, Adrian

    2009-01-01

    "Last September, the world's highest-engery particle smasher - the Large Hadron Collider, or LHC - mangled itself when a splice in a superconducting electrical line melted and set off a chain reaction of mechanical failure [..]. Since then, physicists here at the European particle physics laboratory, Cern, have installed exquisitely sensitive warning systems to monitor the delicate splices and head off a similar catastrophe" (1.5 pages)

  10. Restarted Exchange Rate Reform Raises New Doubts on RMB Appreciation

    Institute of Scientific and Technical Information of China (English)

    Zhang Xueqing

    2010-01-01

    @@ The de-pegging of RMB exchange rate from the US dol-lar does not lead to a substantial change in the exchange rate in the short term. Considering the future regime, if the European financial crisis was not lessened, the Euro and other major currencies would continue to devalue against the U.S dollar and the RMB would probably follow suit.

  11. 液层厚度比对环形腔内双层液体的热毛细对流稳定性的影响%Influence of liquid layer depth ratio on stability of thermocapillary flow in annular two-layer system with upper rigid wall

    Institute of Scientific and Technical Information of China (English)

    莫东鸣

    2015-01-01

    In order to understand the liquid layer depth ratio on the stability of two-layer system with upper rigid walls at the microgravity condition,a linear stability analysis of thermocapillary flow in the annular immiscible two-layer system of 5cSt silicone oil and HT-70 was carried out using Implicity Restarted Arnoldi Method (IRAM).Critical values of Marangoni number,wave number and phase velocity were obtained at different liquid layer depth ratios,different aspect ratios of the cavity and different radius rations.The thermofluid wave pattern at the liquid-liquid interface near the critical Marangoni number was also exhibited.%为了了解微重力条件下、水平温度梯度作用时,上部为固壁的环形腔内双层流体系统中液层厚度比对流动稳定性的影响,采用隐式重启 Arnoldi方法(IRAM)对环形池内5cSt 硅油/HT-70双层流体的热对流过程进行了线性稳定性分析,获得了不同液层厚度比下系统流动的临界 Marangoni 数、临界波数、临界相速度,并通过计算特征向量,得到了临界 Marangoni数附近液-液界面的热流体波形态。

  12. Galerkin projection methods for solving multiple related linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Chan, T.F.; Ng, M.; Wan, W.L.

    1996-12-31

    We consider using Galerkin projection methods for solving multiple related linear systems A{sup (i)}x{sup (i)} = b{sup (i)} for 1 {le} i {le} s, where A{sup (i)} and b{sup (i)} are different in general. We start with the special case where A{sup (i)} = A and A is symmetric positive definite. The method generates a Krylov subspace from a set of direction vectors obtained by solving one of the systems, called the seed system, by the CG method and then projects the residuals of other systems orthogonally onto the generated Krylov subspace to get the approximate solutions. The whole process is repeated with another unsolved system as a seed until all the systems are solved. We observe in practice a super-convergence behaviour of the CG process of the seed system when compared with the usual CG process. We also observe that only a small number of restarts is required to solve all the systems if the right-hand sides are close to each other. These two features together make the method particularly effective. In this talk, we give theoretical proof to justify these observations. Furthermore, we combine the advantages of this method and the block CG method and propose a block extension of this single seed method. The above procedure can actually be modified for solving multiple linear systems A{sup (i)}x{sup (i)} = b{sup (i)}, where A{sup (i)} are now different. We can also extend the previous analytical results to this more general case. Applications of this method to multiple related linear systems arising from image restoration and recursive least squares computations are considered as examples.

  13. Analysis of forest fires causes and their motivations in northern Algeria: the Delphi method

    Directory of Open Access Journals (Sweden)

    Meddour-Sahar O

    2013-06-01

    Full Text Available Forest fires in Algeria are mostly human-caused and result from local social behavior, whether voluntary (arson or involuntary (negligence. Understanding the reasons why fires start is, therefore, a crucial factor in preventing or reducing their incidence, developing significant prevention efforts and designing specific fire prevention campaigns. The Delphi method is a promising tool for improving knowledge about how fire starts and why, and above all helps reduce the number of fires started by unknown causes, the majority type in Algeria. The Delphi method uses a set of procedures for eliciting and refining the opinions of a panel of experts on a particular subject of interest. This method was used in three case studies, in coastal or inner wilayas (provinces selected from a highly fire-prone area in north-central Algeria. Results showed the traditional use of fire in agriculture and forestry, in situations related to land use changes and in interpersonal conflicts are the major causes of voluntary fires. For involuntary events (negligence, experts unanimously identified the importance of the restart of fire, caused by fire crews who do not ensure the mopping up of controlled fires (91.49% and the negligent use of agricultural fires, particularly stubble burning (80.14%. For voluntary fires (arson, results highlight the importance of fires set for land use changes (77.30%, pyromania (67.38% and honey gathering (62.41%. Illegal dumping and burning of garbage was also mentioned by responders in all study-areas.

  14. Efficient Data Gathering Methods in Wireless Sensor Networks Using GBTR Matrix Completion

    Science.gov (United States)

    Wang, Donghao; Wan, Jiangwen; Nie, Zhipeng; Zhang, Qiang; Fei, Zhijie

    2016-01-01

    To obtain efficient data gathering methods for wireless sensor networks (WSNs), a novel graph based transform regularized (GBTR) matrix completion algorithm is proposed. The graph based transform sparsity of the sensed data is explored, which is also considered as a penalty term in the matrix completion problem. The proposed GBTR-ADMM algorithm utilizes the alternating direction method of multipliers (ADMM) in an iterative procedure to solve the constrained optimization problem. Since the performance of the ADMM method is sensitive to the number of constraints, the GBTR-A2DM2 algorithm obtained to accelerate the convergence of GBTR-ADMM. GBTR-A2DM2 benefits from merging two constraint conditions into one as well as using a restart rule. The theoretical analysis shows the proposed algorithms obtain satisfactory time complexity. Extensive simulation results verify that our proposed algorithms outperform the state of the art algorithms for data collection problems in WSNs in respect to recovery accuracy, convergence rate, and energy consumption. PMID:27657085

  15. Efficient Data Gathering Methods in Wireless Sensor Networks Using GBTR Matrix Completion

    Directory of Open Access Journals (Sweden)

    Donghao Wang

    2016-09-01

    Full Text Available To obtain efficient data gathering methods for wireless sensor networks (WSNs, a novel graph based transform regularized (GBTR matrix completion algorithm is proposed. The graph based transform sparsity of the sensed data is explored, which is also considered as a penalty term in the matrix completion problem. The proposed GBTR-ADMM algorithm utilizes the alternating direction method of multipliers (ADMM in an iterative procedure to solve the constrained optimization problem. Since the performance of the ADMM method is sensitive to the number of constraints, the GBTR-A2DM2 algorithm obtained to accelerate the convergence of GBTR-ADMM. GBTR-A2DM2 benefits from merging two constraint conditions into one as well as using a restart rule. The theoretical analysis shows the proposed algorithms obtain satisfactory time complexity. Extensive simulation results verify that our proposed algorithms outperform the state of the art algorithms for data collection problems in WSNs in respect to recovery accuracy, convergence rate, and energy consumption.

  16. A Non-Blocking Locking Method and Performance Evaluation on Network of Workstations

    Institute of Scientific and Technical Information of China (English)

    于戈; 王国仁; 郑怀远; 金泰勇

    2001-01-01

    A network of workstation (NOW) can act as a single and scalable powerful computer by building a parallel and distributed computing platform on top of it. WAKASHI is such a platform system that supports persistent object management and makes full use of resources of NOW for high performance transaction processing. One of the main difficulties to overcome is the bottleneck caused by concurrency control mechanism. Therefore, a non-blocking locking method is designed, by adopting several novel techniques to make it outperform the other typical locking methods such as 2PL: 1) an SDG (Semantic Dependency Graph) based non-blocking locking protocol for fast transaction scheduling; 2) a massively virtual memory based backup-page undo algorithm for fast restart; and 3) a multi-processor and multi-thread based transaction manager for fast execution. The new mechanisms have been implemented in WAKASHI and the performance comparison experiments with 2PL and DWDL have been done. The results show that the new method can outperform 2PL and DWDL under certain conditions. This is meaningful for choosing effective concurrency control mechanisms for improving transaction-processing performance in NOW environments.

  17. A New In-core Production Method of Co-60 in CANDU Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Lyu, Jinqi; Kim, Woosong; Kim, Yonghee [KAIST, Daejeon (Korea, Republic of); Park, Younwon [BEES Inc, Daejeon (Korea, Republic of)

    2016-05-15

    This study introduces an innovative method for Co-60 production in the CANDU6 core. In this new scheme, the central fuel element is replaced by a Co-59 target and Co-60 is obtained after the fuel bundle is discharged. It has been shown that the new method can produce significantly higher amount of Co-60 than the conventional Co production method in CANDU6 reactors without compromising the fuel burnup by removing some (<50%) of the adjuster rods in the whole core. The coolant void reactivity is noticeably reduced when a Co-59 target is loaded into the central pin of the fuel bundle. Meanwhile, the peak power in a fuel bundle is just a little higher due to the central Co-59 target than in conventional CANDU6 fuel design. The basic technology for Co-60 producing was developed by MDS Nordion and Atomic Energy of Canada Limited (AECL) in 1946 and the same technology was adapted and applied in CANDU6 power reactors. The standard CANDU6 reactor has 21 adjuster rods which are fully inserted into the core during normal operation. The stainless steel adjuster rods are replaced with neutronically-equivalent Co-59 adjusters to produce Co-60. Nowadays, the roles of the adjuster rods are rather vague since nuclear reactors cannot be quickly restarted after a sudden reactor trip due to more stringent regulations. In some Canadian CANDU6 reactors, some or all the adjuster rods are removed from the core to maximize the uranium utilization.

  18. Implementation of Preconditioned Krylov Subspace Method in MATRA Code for Whole Core Analysis of SMART

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Hyuk; Kim, S. J.; Park, J. P.; Hwang, D. H. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    Krylov subspace method was implemented to perform the efficient whole core calculation of SMART with pin by pin subchannel model without lumping channel. The SMART core consisted of 57 fuel assemblies of 17 by 17 arrays with 264 fuel rods and 25 guide tubes and there are total 15,048 fuel rods and 16,780 subchannels. Restarted GMRES and BiCGStab methods are selected among Krylov subspace methods. For the purpose of verifying the implementation of Krylov method, whole core problem is considered under the normal operating condition. In this problem, solving a linear system Aχ = b is considered when A is nearly symmetric and when the system is preconditioned with incomplete LU factorization(ILU). The preconditioner using incomplete LU factorization are among the most effective preconditioners for solving general large, sparse linear systems arising from practical engineering problem. The Krylov subspace method is expected to improve the calculation effectiveness of MATRA code rather than direct method and stationary iteration method such as Gauss elimination and SOR. The present study describes the implementation of Krylov subspace methods with ILU into MATRA code. In this paper, we explore an improved performance of MATRA code for the SMART whole core problems by of Krylov subspace method. For this purpose, two preconditioned Krylov subspace methods, GMRES and BiCGStab, are implemented into the subchannel code MATRA. A typical ILU method is used as the preconditioner. Numerical problems examined in this study indicate that the Krylov subspace method shows the outstanding improvements in the calculation speed and easy convergence.

  19. Methods for microwave heat treatment of manufactured components

    Science.gov (United States)

    Ripley, Edward B.

    2010-08-03

    An apparatus for heat treating manufactured components using microwave energy and microwave susceptor material. Heat treating medium such as eutectic salts may be employed. A fluidized bed introduces process gases which may include carburizing or nitriding gases. The process may be operated in a batch mode or continuous process mode. A microwave heating probe may be used to restart a frozen eutectic salt bath.

  20. Iterative methods for solving Ax=b, GMRES/FOM versus QMR/BiCG

    Energy Technology Data Exchange (ETDEWEB)

    Cullum, J. [IBM Research Division, Yorktown Heights, NY (United States)

    1996-12-31

    We study the convergence of GMRES/FOM and QMR/BiCG methods for solving nonsymmetric Ax=b. We prove that given the results of a BiCG computation on Ax=b, we can obtain a matrix B with the same eigenvalues as A and a vector c such that the residual norms generated by a FOM computation on Bx=c are identical to those generated by the BiCG computations. Using a unitary equivalence for each of these methods, we obtain test problems where we can easily vary certain spectral properties of the matrices. We use these test problems to study the effects of nonnormality on the convergence of GMRES and QMR, to study the effects of eigenvalue outliers on the convergence of QMR, and to compare the convergence of restarted GMRES, QMR, and BiCGSTAB across a family of normal and nonnormal problems. Our GMRES tests on nonnormal test matrices indicate that nonnormality can have unexpected effects upon the residual norm convergence, giving misleading indications of superior convergence over QMR when the error norms for GMRES are not significantly different from those for QMR. Our QMR tests indicate that the convergence of the QMR residual and error norms is influenced predominantly by small and large eigenvalue outliers and by the character, real, complex, or nearly real, of the outliers and the other eigenvalues. In our comparison tests QMR outperformed GMRES(10) and GMRES(20) on both the normal and nonnormal test matrices.

  1. Delta-f and hydrodynamic methods for semiconductor transport

    Energy Technology Data Exchange (ETDEWEB)

    Thode, L.E.; Hotchkiss, R.; Gray, M.; Snell, C.; Barnes, D.

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory. The authors have developed a prototype plug-and-play (PCUBED) environment based upon a C++ class called a fragment. A fragment is a universal object that can represent any data type. Fragments provide an excellent intuitive approach to the development of an efficient architecture, as well as providing a common data implementation within and between codes. As a result, the PCUBED environment allows for the generation of many different codes within a common framework. At this time, there are seven major codes implemented within the PCUBED environment. Input, output, restart, setup, and graphics are programmed using a high-level approach to insure human efficiency. In contrast, computationally intensive algorithms are programmed using a low-level approach to insure computational efficiency. Fragments provide a straightforward approach to switch between high-level and low-level programming. PCUBED has been tested on a Macintosh PowerPC; on IBM, SUN, HP, and SGI workstations; and on the CRAY YMP and Cray T3D. Using this environment, the authors have incorporated a drift diffusion, energy balance, hydrodynamic, and Monte Carlo model for metal-oxide semiconductor field-effect transistors (MOSFETs) into a single architecture. With all the models in a common framework, they have investigated the noise characteristics of hybrid and delta-f models. Although hybrid and delta-f models appear viable in one dimension, the noise level of higher order transport coefficients in two and three dimensions makes the utility of such combined methods questionable.

  2. A simple and efficient method for the long-term preservation of plant cell suspension cultures

    Directory of Open Access Journals (Sweden)

    Boisson Anne-Marie

    2012-01-01

    Full Text Available Abstract Background The repeated weekly subculture of plant cell suspension is labour intensive and increases the risk of variation from parental cells lines. Most of the procedures to preserve cultures are based on controlled freezing/thawing and storage in liquid nitrogen. However, cells viability after unfreezing is uncertain. The long-term storage and regeneration of plant cell cultures remains a priority. Results Sycamore (Acer pseudoplatanus and Arabidopsis cell were preserved over six months as suspensions cultures in a phosphate-free nutrient medium at 5°C. The cell recovery monitored via gas exchange measurements and metabolic profiling using in vitro and in vivo 13C- and 31P-NMR took a couple of hours, and cell growth restarted without appreciable delay. No measurable cell death was observed. Conclusion We provide a simple method to preserve physiologically homogenous plant cell cultures without subculture over several months. The protocol based on the blockage of cell growth and low culture temperature is robust for heterotrophic and semi-autotrophic cells and should be adjustable to cell lines other than those utilised in this study. It requires no specialized equipment and is suitable for routine laboratory use.

  3. Perturbation methods

    CERN Document Server

    Nayfeh, Ali H

    2008-01-01

    1. Introduction 1 2. Straightforward Expansions and Sources of Nonuniformity 23 3. The Method of Strained Coordinates 56 4. The Methods of Matched and Composite Asymptotic Expansions 110 5. Variation of Parameters and Methods of Averaging 159 6. The Method of Multiple Scales 228 7. Asymptotic Solutions of Linear Equations 308 References and Author Index 387 Subject Index 417

  4. On acceleration of Krylov-subspace-based Newton and Arnoldi iterations for incompressible CFD: replacing time steppers and generation of initial guess

    CERN Document Server

    Gelfgat, Alexander

    2016-01-01

    We propose two techniques aimed at improving the convergence rate of steady state and eigenvalue solvers preconditioned by the inverse Stokes operator and realized via time-stepping. First, we suggest a generalization of the Stokes operator so that the resulting preconditioner operator depends on several parameters and whose action preserves zero divergence and boundary conditions. The parameters can be tuned for each problem to speed up the convergence of a Krylov-subspace-based linear algebra solver. This operator can be inverted by the Uzawa-like algorithm, and does not need a time-stepping. Second, we propose to generate an initial guess of steady flow, leading eigenvalue and eigenvector using orthogonal projection on divergence-free basis satisfying all boundary conditions. The approach, including the two proposed techniques, is illustrated on the solution of the linear stability problem for laterally heated square and cubic cavities.

  5. Solving Large Scale Nonlinear Eigenvalue Problem in Next-Generation Accelerator Design

    Energy Technology Data Exchange (ETDEWEB)

    Liao, Ben-Shan; Bai, Zhaojun; /UC, Davis; Lee, Lie-Quan; Ko, Kwok; /SLAC

    2006-09-28

    A number of numerical methods, including inverse iteration, method of successive linear problem and nonlinear Arnoldi algorithm, are studied in this paper to solve a large scale nonlinear eigenvalue problem arising from finite element analysis of resonant frequencies and external Q{sub e} values of a waveguide loaded cavity in the next-generation accelerator design. They present a nonlinear Rayleigh-Ritz iterative projection algorithm, NRRIT in short and demonstrate that it is the most promising approach for a model scale cavity design. The NRRIT algorithm is an extension of the nonlinear Arnoldi algorithm due to Voss. Computational challenges of solving such a nonlinear eigenvalue problem for a full scale cavity design are outlined.

  6. Vortex methods

    Energy Technology Data Exchange (ETDEWEB)

    Chorin, A.J. [California Univ., Berkeley, CA (United States). Dept. of Mathematics]|[Lawrence Berkeley Lab., CA (United States)

    1993-06-01

    Vortex methods originated from the observation that in incompressible inviscid flow vorticity (or, more accurately, circulation) is a conserved quantity, as can be readily deduced from the absence of tangential stresses. Thus, if the vorticity is known at time t=0, one can find the flow at a later time by simply following the vorticity. In this narrow context, a vortex method is a numerical method that follows vorticity. The author restricts himself in these lectures to a special class of numerical vortex methods, those that are based on a Lagrangian transport of vorticity in hydrodynamics by smoothed particles (blobs) and those whose analysis contributes to the understanding of blob methods. Blob methods started in the 1930`s.

  7. Mining Method

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Shik; Lee, Kyung Woon; Kim, Oak Hwan; Kim, Dae Kyung [Korea Institute of Geology Mining and Materials, Taejon (Korea, Republic of)

    1996-12-01

    The reducing coal market has been enforcing the coal industry to make exceptional rationalization and restructuring efforts since the end of the eighties. To the competition from crude oil and natural gas has been added the growing pressure from rising wages and rising production cost as the workings get deeper. To improve the competitive position of the coal mines against oil and gas through cost reduction, studies to improve mining system have been carried out. To find fields requiring improvements most, the technologies using in Tae Bak Colliery which was selected one of long running mines were investigated and analyzed. The mining method appeared the field needing improvements most to reduce the production cost. The present method, so-called inseam roadway caving method presently is using to extract the steep and thick seam. However, this method has several drawbacks. To solve the problems, two mining methods are suggested for a long term and short term method respectively. Inseam roadway caving method with long-hole blasting method is a variety of the present inseam roadway caving method modified by replacing timber sets with steel arch sets and the shovel loaders with chain conveyors. And long hole blasting is introduced to promote caving. And pillar caving method with chock supports method uses chock supports setting in the cross-cut from the hanging wall to the footwall. Two single chain conveyors are needed. One is installed in front of chock supports to clear coal from the cutting face. The other is installed behind the supports to transport caved coal from behind. This method is superior to the previous one in terms of safety from water-inrushes, production rate and productivity. The only drawback is that it needs more investment. (author). 14 tabs., 34 figs.

  8. Projection Methods

    DEFF Research Database (Denmark)

    Wagner, Falko Jens; Poulsen, Mikael Zebbelin

    1999-01-01

    When trying to solve a DAE problem of high index with more traditional methods, it often causes instability in some of the variables, and finally leads to breakdown of convergence and integration of the solution. This is nicely shown in [ESF98, p. 152 ff.].This chapter will introduce projection...... methods as a way of handling these special problems. It is assumed that we have methods for solving normal ODE systems and index-1 systems....

  9. Computing methods

    CERN Document Server

    Berezin, I S

    1965-01-01

    Computing Methods, Volume 2 is a five-chapter text that presents the numerical methods of solving sets of several mathematical equations. This volume includes computation sets of linear algebraic equations, high degree equations and transcendental equations, numerical methods of finding eigenvalues, and approximate methods of solving ordinary differential equations, partial differential equations and integral equations.The book is intended as a text-book for students in mechanical mathematical and physics-mathematical faculties specializing in computer mathematics and persons interested in the

  10. Method 59

    DEFF Research Database (Denmark)

    Kjellsson, G.

    1994-01-01

    OCDE/GD(94)41. Er supplerende rapport til rapport: The OECD Workshop on Methods for Monitoring Organisms in the Environment, Ottawa 14-17 September 1992. Environment Monograph 90.......OCDE/GD(94)41. Er supplerende rapport til rapport: The OECD Workshop on Methods for Monitoring Organisms in the Environment, Ottawa 14-17 September 1992. Environment Monograph 90....

  11. Spectral properties of Google matrix of Wikipedia and other networks

    Science.gov (United States)

    Ermann, Leonardo; Frahm, Klaus M.; Shepelyansky, Dima L.

    2013-05-01

    We study the properties of eigenvalues and eigenvectors of the Google matrix of the Wikipedia articles hyperlink network and other real networks. With the help of the Arnoldi method, we analyze the distribution of eigenvalues in the complex plane and show that eigenstates with significant eigenvalue modulus are located on well defined network communities. We also show that the correlator between PageRank and CheiRank vectors distinguishes different organizations of information flow on BBC and Le Monde web sites.

  12. Spectral properties of Google matrix of Wikipedia and other networks

    CERN Document Server

    Ermann, Leonardo; Shepelyansky, Dima L

    2014-01-01

    We study the properties of eigenvalues and eigenvectors of the Google matrix of the Wikipedia articles hyperlink network and other real networks. With the help of the Arnoldi method we analyze the distribution of eigenvalues in the complex plane and show that eigenstates with significant eigenvalue modulus are located on well defined network communities. We also show that the correlator between PageRank and CheiRank vectors distinguishes different organizations of information flow on BBC and Le Monde web sites.

  13. PartialRC: A Partial Recomputing Method for Efficient Fault Recovery on GPGPUs

    Institute of Scientific and Technical Information of China (English)

    Xin-Hai Xu; Xue-Jun Yang; Jing-Ling Xue; Yu-Fei Lin; Yi-Song Lin

    2012-01-01

    GPGPUs are increasingly being used to as performance accelerators for HPC (High Performance Computing) applications in CPU/GPU heterogeneous computing systems,including TianHe-lA,the world's fastest supercomputer in the TOP500 list,built at NUDT (National University of Defense Technology) last year.However,despite their performance advantages,GPGPUs do not provide built-in fault-tolerant mechanisms to offer reliability guarantees required by many HPC applications.By analyzing the SIMT (single-instruction,multiple-thread) characteristics of programs running on GPGPUs,we have developed PartialRC,a new checkpoint-based compiler-directed partial recomputing method,for achieving efficient fault recovery by leveraging the phenomenal computing power of GPGPUs.In this paper,we introduce our PartialRC method that recovers from errors detected in a code region by partially re-computing the region,describe a checkpoint-based faulttolerance framework developed on PartialRC,and discuss an implementation on the CUDA platform.Validation using a range of representative CUDA programs on NVIDIA GPGPUs against FullRC (a traditional full-recomputing CheckpointRollback-Restart fault recovery method for CPUs) shows that PartialRC reduces significantly the fault recovery overheads incurred by FulIRC,by 73.5% when errors occur earlier during execution and 74.6% when errors occur later on average.In addition,PartialRC also reduces error detection overheads incurred by FullRC during fault recovery while incurring negligible performance overheads when no fault happens.

  14. Explicit schemes for time propagating many-body wavefunctions

    CERN Document Server

    Frapiccini, Ana Laura; Schröter, Sebastian; Pyke, Dean; Mota-Furtado, Francisca; O'Mahony, Patrick F; Madroñero, Javier; Eiglsperger, Johannes; Piraux, Bernard

    2014-01-01

    Accurate theoretical data on many time-dependent processes in atomic and molecular physics and in chemistry require the direct numerical solution of the time-dependent Schr\\"odinger equation, thereby motivating the development of very efficient time propagators. These usually involve the solution of very large systems of first order differential equations that are characterized by a high degree of stiffness. We analyze and compare the performance of the explicit one-step algorithms of Fatunla and Arnoldi. Both algorithms have exactly the same stability function, therefore sharing the same stability properties that turn out to be optimum. Their respective accuracy however differs significantly and depends on the physical situation involved. In order to test this accuracy, we use a predictor-corrector scheme in which the predictor is either Fatunla's or Arnoldi's algorithm and the corrector, a fully implicit four-stage Radau IIA method of order 7. We consider two physical processes. The first one is the ionizat...

  15. Method Mixins

    DEFF Research Database (Denmark)

    Ernst, Erik

    2005-01-01

    , where traditional invocation is optimized for as-is reuse of existing behavior. Tight coupling reduces flexibility, and traditional invocation tightly couples transfer of information and transfer of control. Method mixins decouple these two kinds of transfer, thereby opening the doors for new kinds......The world of programming has been conquered by the procedure call mechanism, including object-oriented method invocation which is a procedure call in context of an object. This paper presents an alternative, method mixin invocations, that is optimized for flexible creation of composite behavior...

  16. Method Mixins

    DEFF Research Database (Denmark)

    Ernst, Erik

    2002-01-01

    invocation is optimized for as-is reuse of existing behavior. Tight coupling reduces flexibility, and traditional invocation tightly couples transfer of information and transfer of control. Method mixins decouple these two kinds of transfer, thereby opening the doors for new kinds of abstraction and reuse......The procedure call mechanism has conquered the world of programming, with object-oriented method invocation being a procedure call in context of an object. This paper presents an alternative, method mixin invocations, that is optimized for flexible creation of composite behavior, where traditional...

  17. Dosimetry methods

    DEFF Research Database (Denmark)

    McLaughlin, W.L.; Miller, A.; Kovacs, A.;

    2003-01-01

    Chemical and physical radiation dosimetry methods, used for the measurement of absorbed dose mainly during the practical use of ionizing radiation, are discussed with respect to their characteristics and fields of application.......Chemical and physical radiation dosimetry methods, used for the measurement of absorbed dose mainly during the practical use of ionizing radiation, are discussed with respect to their characteristics and fields of application....

  18. Ensemble Methods

    Science.gov (United States)

    Re, Matteo; Valentini, Giorgio

    2012-03-01

    Ensemble methods are statistical and computational learning procedures reminiscent of the human social learning behavior of seeking several opinions before making any crucial decision. The idea of combining the opinions of different "experts" to obtain an overall “ensemble” decision is rooted in our culture at least from the classical age of ancient Greece, and it has been formalized during the Enlightenment with the Condorcet Jury Theorem[45]), which proved that the judgment of a committee is superior to those of individuals, provided the individuals have reasonable competence. Ensembles are sets of learning machines that combine in some way their decisions, or their learning algorithms, or different views of data, or other specific characteristics to obtain more reliable and more accurate predictions in supervised and unsupervised learning problems [48,116]. A simple example is represented by the majority vote ensemble, by which the decisions of different learning machines are combined, and the class that receives the majority of “votes” (i.e., the class predicted by the majority of the learning machines) is the class predicted by the overall ensemble [158]. In the literature, a plethora of terms other than ensembles has been used, such as fusion, combination, aggregation, and committee, to indicate sets of learning machines that work together to solve a machine learning problem [19,40,56,66,99,108,123], but in this chapter we maintain the term ensemble in its widest meaning, in order to include the whole range of combination methods. Nowadays, ensemble methods represent one of the main current research lines in machine learning [48,116], and the interest of the research community on ensemble methods is witnessed by conferences and workshops specifically devoted to ensembles, first of all the multiple classifier systems (MCS) conference organized by Roli, Kittler, Windeatt, and other researchers of this area [14,62,85,149,173]. Several theories have been

  19. Statistical methods

    CERN Document Server

    Szulc, Stefan

    1965-01-01

    Statistical Methods provides a discussion of the principles of the organization and technique of research, with emphasis on its application to the problems in social statistics. This book discusses branch statistics, which aims to develop practical ways of collecting and processing numerical data and to adapt general statistical methods to the objectives in a given field.Organized into five parts encompassing 22 chapters, this book begins with an overview of how to organize the collection of such information on individual units, primarily as accomplished by government agencies. This text then

  20. Sieve methods

    CERN Document Server

    Halberstam, Heine

    2011-01-01

    Derived from the techniques of analytic number theory, sieve theory employs methods from mathematical analysis to solve number-theoretical problems. This text by a noted pair of experts is regarded as the definitive work on the subject. It formulates the general sieve problem, explores the theoretical background, and illustrates significant applications.""For years to come, Sieve Methods will be vital to those seeking to work in the subject, and also to those seeking to make applications,"" noted prominent mathematician Hugh Montgomery in his review of this volume for the Bulletin of the Ameri

  1. Spectral Methods

    CERN Document Server

    Shen, Jie; Wang, Li-Lian

    2011-01-01

    Along with finite differences and finite elements, spectral methods are one of the three main methodologies for solving partial differential equations on computers. This book provides a detailed presentation of basic spectral algorithms, as well as a systematical presentation of basic convergence theory and error analysis for spectral methods. Readers of this book will be exposed to a unified framework for designing and analyzing spectral algorithms for a variety of problems, including in particular high-order differential equations and problems in unbounded domains. The book contains a large

  2. Statistical methods

    CERN Document Server

    Freund, Rudolf J; Wilson, William J

    2010-01-01

    Statistical Methods, 3e provides students with a working introduction to statistical methods offering a wide range of applications that emphasize the quantitative skills useful across many academic disciplines. This text takes a classic approach emphasizing concepts and techniques for working out problems and intepreting results. The book includes research projects, real-world case studies, numerous examples and data exercises organized by level of difficulty. This text requires that a student be familiar with algebra. New to this edition: NEW expansion of exercises a

  3. Digital Methods

    NARCIS (Netherlands)

    Rogers, R.

    2013-01-01

    In Digital Methods, Richard Rogers proposes a methodological outlook for social and cultural scholarly research on the Web that seeks to move Internet research beyond the study of online culture. It is not a toolkit for Internet research, or operating instructions for a software package; it deals wi

  4. Characterization methods

    Energy Technology Data Exchange (ETDEWEB)

    Glass, J.T. [North Carolina State Univ., Raleigh (United States)

    1993-01-01

    Methods discussed in this compilation of notes and diagrams are Raman spectroscopy, scanning electron microscopy, transmission electron microscopy, and other surface analysis techniques (auger electron spectroscopy, x-ray photoelectron spectroscopy, electron energy loss spectroscopy, and scanning tunnelling microscopy). A comparative evaluation of different techniques is performed. In-vacuo and in-situ analyses are described.

  5. Radiofluorination method

    DEFF Research Database (Denmark)

    2014-01-01

    A method of conducting radiofluorination of a substrate, comprising the steps of: (a) contacting an aqueous solution of [18F] fluoride with a polymer supported phosphazene base for sufficient time for trapping of [18F] fluoride on the polymer supported phosphazene base; and (b) contacting...

  6. Contraceptive Methods.

    Science.gov (United States)

    Colquitt, Charlie W; Martin, Tonya S

    2017-02-01

    The prevention of pregnancy remains an important part of the practice of medicine. Contraception can occur at a number of points in the basic reproductive biological process and through a number of contraceptive product options. Pharmacists are health care providers appropriately positioned to assist patients in suitable contraceptive product selection based on their personal situations and lifestyles. This article provides an overview of available products for prevention of pregnancy and associated risks and benefits. Contraceptive products are categorized by their hormonal content and method of action. Hormonal options include oral contraceptive pills, contraceptive patch, implants, injection, intravaginal, and intrauterine devices. Barrier products prevent pregnancy by creating a physical obstacle to the successful fertilization of an egg by sperm. All products and methods are associated with benefits and potential complications that must be considered as patients, and health care providers select the most satisfactory option.

  7. Numerical methods

    CERN Document Server

    Dahlquist, Germund

    2003-01-01

    ""Substantial, detailed and rigorous . . . readers for whom the book is intended are admirably served."" - MathSciNet (Mathematical Reviews on the Web), American Mathematical Society.Practical text strikes fine balance between students' requirements for theoretical treatment and needs of practitioners, with best methods for large- and small-scale computing. Prerequisites are minimal (calculus, linear algebra, and preferably some acquaintance with computer programming). Text includes many worked examples, problems, and an extensive bibliography.

  8. Multi-frequency accelerating strategy for the contrast source inversion method of ultrasound waveform tomography using pulse data

    Science.gov (United States)

    Lin, Hongxiang; Azuma, Takashi; Qu, Xiaolei; Takagi, Shu

    2017-03-01

    In this work, we construct a multi-frequency accelerating strategy for the contrast source inversion (CSI) method using pulse data in the time domain. CSI is a frequency-domain inversion method for ultrasound waveform tomography that does not require the forward solver through the process of reconstruction. Several prior researches show that the CSI method has a good performance of convergence and accuracy in the low-center-frequency situation. In contrast, utilizing the high-center-frequency data leads to a high-resolution reconstruction but slow convergence on large numbers of grid. Our objective is to take full advantage of all low frequency components from pulse data with the high-center-frequency data measured by the diagnostic device. First we process the raw data in the frequency domain. Then multi-frequency accelerating strategy helps restart CSI in the current frequency using the last iteration result obtained from the lower frequency component. The merit of multi- frequency accelerating strategy is that computational burden decreases at the first few iterations. Because the low frequency component of dataset computes on the coarse grid with assuming a fixed number of points per wavelength. In the numerical test, the pulse data were generated by the K-wave simulator and have been processed to meet the computation of the CSI method. We investigate the performance of the multi-frequency and single-frequency reconstructions and conclude that the multi-frequency accelerating strategy significantly enhances the quality of the reconstructed image and simultaneously reduces the average computational time for any iteration step.

  9. Calculation methods of reactivity using derivatives of nuclear power and Filter fir; Metodos para o calculo da reatividade usando derivadas da potencia nuclear e o filtro FIR

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, Daniel Suescun

    2007-07-01

    This work presents two new methods for the solution of the inverse point kinetics equation. The first method is based on the integration by parts of the integral of the inverse point kinetics equation, which results in a power series in terms of the nuclear power in time dependence. Applying some conditions to the nuclear power, the reactivity is represented as first and second derivatives of this nuclear power. This new calculation method for reactivity has special characteristics, amongst which the possibility of using different sampling periods, and the possibility of restarting the calculation, after its interruption associated it with a possible equipment malfunction, allowing the calculation of reactivity in a non-continuous way. Apart from this reactivity can be obtained with or without dependency on the nuclear power memory. The second method is based on the Laplace transform of the point kinetics equations, resulting in an expression equivalent to the inverse kinetics equation as a function of the power history. The reactivity can be written in terms of the summation of convolution with response to impulse, characteristic of a linear system. For its digital form the Z-transform is used, which is the discrete version of the Laplace transform. In this method it can be pointed out that the linear part is equivalent to a filter named Finite Impulse Response (Fir). The Fir filter will always be, stable and non-varying in time, and, apart from this, it can be implemented in the non-recursive way. This type of implementation does not require feedback, allowing the calculation of reactivity in a continuous way. The proposed methods were validated using signals with random noise and showing the relationship between the reactivity difference and the degree of the random noise. (author)

  10. Activity restart - a key to explaining the morphology of J1211+743

    CERN Document Server

    Marecki, Andrzej

    2012-01-01

    J1211+743 is a giant radio galaxy with a one-sided jet and two asymmetric lobes, one of which is of Fanaroff-Riley (FR) type II with a hotspot and the other is a diffuse relic devoid of a hotspot. The jet points towards the latter lobe, which is difficult to explain in a standard way within the double-lobed radio source paradigm. Here, I propose to assume that the nucleus of J1211+743 has undergone a re-ignition of activity and its lobes, presumably both originally of FR II type, represent an earlier active phase, while the jet represents the current one. The asymmetry of the lobes is a consequence of the orientation of the source combined with an activity switch-off that occurred between two active periods. The relic lobe is on the near side with regard to the observer, whereas the radiation from the far-side lobe arrives significantly later owing to its longer distance to the observer. The far-side lobe is thus perceived to have not yet decayed. On the other hand, the jet behaves in a standard way, i.e. its...

  11. Geomagnetic reversal rates following Palaeozoic superchrons have a fast restart mechanism.

    Science.gov (United States)

    Hounslow, Mark W

    2016-08-30

    Long intervals of single geomagnetic polarity (superchrons) reflect geodynamo processes, driven by core-mantle boundary interactions; however, it is not clear what initiates the start and end of superchrons, other than superchrons probably reflect lower heat flow across the core-mantle boundary compared with adjacent intervals. Here geomagnetic polarity timescales, with confidence intervals, are constructed before and following the reverse polarity Kiaman (Carboniferous-Permian) and Moyero (Ordovician) superchrons, providing a window into the geodynamo processes. Similar to the Cretaceous, asymmetry in reversal rates is seen in the Palaeozoic superchrons, but the higher reversal rates imply higher heatflow thresholds for entering the superchron state. Similar to the Cretaceous superchron, unusually long-duration chrons characterize the ∼10 Myr interval adjacent to the superchrons, indicating a transitional reversing state to the superchrons. This may relate to a weak pattern in the clustering of chron durations superimposed on the dominant random arrangement of chron durations.

  12. Gearing up chromatin: A role for chromatin remodeling during the transcriptional restart upon DNA damage

    NARCIS (Netherlands)

    I.K. Mandemaker (Imke); W. Vermeulen (Wim); J.A. Marteijn (Jurgen)

    2014-01-01

    textabstractDuring transcription, RNA polymerase may encounter DNA lesions, which causes stalling of transcription. To overcome the RNA polymerase blocking lesions, the transcribed strand is repaired by a dedicated repair mechanism, called transcription coupled nucleotide excision repair (TC-NER). A

  13. Volatile Organic Analyzer (VOA) in 2006: Repair, Revalidation, and Restart of Elektron Event

    Science.gov (United States)

    Limero, Thomas

    2007-01-01

    The Volatile Organic Analyzer (VOA) was launched to the International Space Station (ISS) in August 2001 and was the first instrument to provide near real-time measurement of volatile organic compounds in a spacecraft atmosphere. The VOA performed an analysis of the ISS air approximately twice a month for most of its operation through May 2003. This intermittent operation, caused by a software interface issue with the ISS communication bus, slowed the validation of the VOA. However, operational validation was completed in 2003 when analysis of air samples collected in grab sample containers (GSCs) compared favorably with simultaneous VOA runs (1). The VOA has two channels that provide redundant function, albeit at slightly reduced performance, when only one channel is operating (2). Most target compounds can be detected on both channels. In January 2003, the VOA identified a malfunction in the channel 2 preconcentrator and it shut down that channel. The anomaly profile suggested that a fuse might have failed, but the root cause could not be determined. In May 2003, channel 1 was shut down when the detector s elevated temperature could not longer be maintained. Since both VOA channels were now deactivated, VOA operations ended until an in-flight repair could be planned and executed. This paper describes the process to repair the VOA and to revalidate it for operations, and then an account is given of the VOA s contribution following a contingency event on ISS.

  14. Volatile Organic Analyzer (VOA) in 2006: Repair, Revalidation, and Restart of Elektron Even

    Science.gov (United States)

    Limero, Thomas

    2007-01-01

    The Volatile Organic Analyzer (VOA) had been providing valuable data on trace contaminants in the atmosphere of the International Space Station (ISS) from January 2002 through May 2003. Component temperature errors, detected by the VOA s software, shut down the unit in May 2003, but in early 2005 on orbit diagnostics verified fuse failures had disabled both VOA channels. An in-flight maintenance (IFM) session in December 2005 returned the VOA to an operational mode by January 2006. This paper will present the on-orbit data from 2006 that were used to revalidate the VOA, and provide an overview of the VOA s contributions during the Elecktron contingency event that occurred on ISS in September 2006.

  15. An increase in bronchial responsiveness is associated with continuing or restarting smoking

    NARCIS (Netherlands)

    Chinn, S; Jarvis, D; Luczynska, CM; Ackermann-Liebrich, U; Anto, JM; Cerveri, [No Value; de Marco, R; Gislason, T; Heinrich, J; Janson, C; Kunzli, N; Leynaert, N; Neukirch, FO; Schouten, JP; Sunyer, J; Svanes, C; Wjst, M; Burney, PG

    2005-01-01

    Rationale: Bronchial responsiveness (BHR) has been found to be associated with smoking, atopy, and lower lung function in cross-sectional studies, but there is little information on determinants of change in adults. Objectives: To analyze change in bronchial responsiveness in an international

  16. Perspectives of clinicians involved in the RESTART-Study : Outcomes of a focus group

    NARCIS (Netherlands)

    de Sonneville-Koedoot, Caroline; Adams, Samantha A; Stolk, Elly A; Franken, Marie-Christine

    2015-01-01

    PURPOSE: The purpose of this study was to explore the attitudes and beliefs of speech-language pathologists (SLPs) with regard to the Lidcombe Program and Demands and Capacities-based treatment and to examine how these attitudes and beliefs might have changed as a result of participating in the REST

  17. 40 CFR 1065.525 - Engine starting, restarting, shutdown, and optional repeating of void discrete modes.

    Science.gov (United States)

    2010-07-01

    ... either an adequately charged battery, a suitable power supply, or a suitable compressed air source. (2...) If the engine stalls at any time after emission sampling begins for a transient test or...

  18. 40 CFR 86.1336-84 - Engine starting, restarting, and shutdown.

    Science.gov (United States)

    2010-07-01

    ... with a fully charged battery. The time taken to accelerate the engine to cranking speed by the... at the same time cranking begins. When the engine starts, the transient engine cycle timing sequence... minute transient cycle followed by a 20 minute soak and then the for-record hot cycle. (2) In no case...

  19. Osteoporosis Treatment:When to Discontinue and When to Re-start

    Institute of Scientific and Technical Information of China (English)

    Silvano Adami; Luca Idolazzi; Elena Fracassi; Davide Gatti; Maurizio Rossini

    2013-01-01

    A number of effective therapies for the treatment of osteoporosis have become available in recent years. However, uncertainty exists regarding their long-term use and effectiveness. Bisphosphonate treatment, unlike hormone replacement, denosumab or teriparatide, is associated with benefits extended even after treatment discontinuation. The extended benefits are most apparent for alendronate (ALN) and zoledronate (ZOL). A drug holiday might be considered in patients at low-moderate risk and who have been fully compliant with treatment, and who have had a response to treatment. In patients at low-moderate risk of fractures the decision to consider a drug holiday should be balanced also with the safety profile of each treatment.

  20. Reversible Posterior Leukoencephalopathy Syndrome Developing After Restart of Sunitinib Therapy for Metastatic Renal Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Shinji Fukui

    2016-01-01

    Full Text Available A 64-year-old Japanese man had started molecular-targeted therapy with sunitinib for lymph node metastasis 5 years after nephrectomy for left renal cell carcinoma (clear cell carcinoma, G2, pT2N0M0. He was transported to our emergency department because of generalized tonic-clonic seizure, vision loss, and impaired consciousness with acute hypertension after 8 cycles of treatment (2 years after the initiation of sunitinib therapy, including a drug withdrawal period for one year. MRI of the brain (FLAIR images showed multiple high-intensity lesions in the white matter of the occipital and cerebellar lobes, dorsal brain stem, and left thalamus. Reversible posterior leukoencephalopathy syndrome caused by sunitinib was suspected. In addition to the immediate discontinuation of sunitinib therapy, the administration of antihypertensive agents and anticonvulsants improved the clinical symptoms without neurological damage. Physicians should be aware that sunitinib causes reversible posterior leukoencephalopathy syndrome. The early recognition of reversible posterior leukoencephalopathy syndrome is critical to avoid irreversible neurological damage.

  1. Restarting radio activity and dust emission in radio-loud broad absorption line quasars

    CERN Document Server

    Bruni, G; Montenegro-Montes, F M; Brienza, M; González-Serrano, J I

    2015-01-01

    Broad absorption line quasars (BAL QSOs) are objects showing absorption from relativistic outflows, with velocities up to 0.2c. These manifest, in about 15% of quasars, as absorption troughs on the blue side of UV emission lines, such as C iv and Mg ii. In this work, we complement the information collected in the cm band for our previously presented sample of radio loud BAL QSOs with new observations at m and mm bands. Our aim is to verify the presence of old, extended radio components in the MHz range, and probe the emission of dust (linked to star formation) in the mm domain. We observed 5 sources from our sample, already presenting hints of low-frequency emission, with the GMRT at 235 and 610 MHz. Other 17 sources (more than half the sample) were observed with bolometer cameras at IRAM-30m and APEX. All sources observed with the GMRT present extended emission at a scale of tens of kpc. In some cases these measurements allow us to identify a second component in the SED, at frequencies below 1.4 GHz, beyond ...

  2. Restarting the cell cycle when the checkpoint comes to a halt

    NARCIS (Netherlands)

    van Vugt, Marcel A T M; Bràs, Alexandra; Medema, René H

    2005-01-01

    The DNA damage checkpoint coordinates a block in cell proliferation with the DNA repair process that follows when lesions are inflicted on the genome. However, we do not know exactly how cell division can recommence following a DNA damage-induced arrest. Recent work from our lab has identified Polo-

  3. LHC Restart 2009 - Accelerating Science - Beam captured just before midnight, November 20th 2009

    CERN Multimedia

    CERN Video Productions

    2009-01-01

    Geneva, 20 November 2009. Particle beams are once again circulating in the world's most powerful particle accelerator, CERN*'s Large Hadron Collider (LHC). This news comes after the machine was handed over for operation on Wednesday morning. A clockwise circulating beam was established at ten o'clock this evening. This is an important milestone on the road towards first physics at the LHC, expected in 2010.

  4. CERN News - Physics restarts in the LHC at new record energy

    CERN Multimedia

    CERN Visual Media Office; Marion Viguier; Paola Catapano

    2012-01-01

    The LHC has started proton collisions at the unprecedent energy of 4 TeV per beam. This video celebrates the new milestone and explains the physics challenges and ecxpectations for the two larger experiments ATLAS and CMS through the words of the current physics coordinators Richard Hawkings and Greg Landsberg.

  5. Beam Splashes seen by the CMS detector #RestartLHC 2017 (end of April 2017)

    CERN Multimedia

    Mc Cauley, Thomas; Zevi Della Porta, Giovanni

    2017-01-01

    CMS event display from LHC beam splash on Saturday, 29th April 2017. This is the first time the full detector has seen particles produced since the beginning of the Extended Year-End Technical Stop (EYETS) 2017. In contrast to proton-proton collisions where the particles come from the center of the detector, in splash events, particles traverse the detector horizontally from one side to the other.

  6. The Battle Isn’t Over——Whaling nations want to restart the hunt

    Institute of Scientific and Technical Information of China (English)

    Kristin; Kovner; Emily; Flynn; 陈青

    2004-01-01

    国际捕鲸委员会成立于第二次世界大战之后,最初的宗旨是有效利用鲸鱼资源。但是随着鲸鱼种类的濒临灭绝,1986年,该委员会做出决议,禁止对这一海洋哺乳动物进行商业性捕猎。随着执行保护措施后鲸鱼数量的增加,捕杀与保护之间的矛盾有所激化。能否在商业利益和动物保护两者中间找到一个平衡点呢?To kill,or not to kill,that is a question.

  7. Conquering the Summit With Firm Strides——Review on the restarted RMB exchange rate reform

    Institute of Scientific and Technical Information of China (English)

    Zhang Ming

    2010-01-01

    @@ On the evening of June 19th 2010, the central bank of China released that "on further advancing the reform in RMB exchange rate formation mechanism and strengthen-ing the flexibility of RMB rate". There were three key points. First, "now that global economy is steadily recovering, and the recovering trend in China is strengthened, it is necessary to further advance reform in RMB exchange rate formation mechanism, and strengthen the flexibility of RMB rate."

  8. Full Impact of Department of Defense Program to Restart State-Owned Enterprises Difficult to Estimate

    Science.gov (United States)

    2009-01-30

    Baiji Fertilizer $6,600,000 Caustic soda flakes, cement, motors, and spare parts Basrah Chemical $250,000 Seals, gaskets, and valves for boilers...State Company for Dairy Products would be impacted when a milk plant under construction is completed in March 2009. However, during our November...2008 visit to the construction site, the engineer estimated that about 600 people would be employed once the milk plant is completed. The Task Force

  9. Comparison of different filter methods for data assimilation in the unsaturated zone

    Science.gov (United States)

    Lange, Natascha; Berkhahn, Simon; Erdal, Daniel; Neuweiler, Insa

    2016-04-01

    The unsaturated zone is an important compartment, which plays a role for the division of terrestrial water fluxes into surface runoff, groundwater recharge and evapotranspiration. For data assimilation in coupled systems it is therefore important to have a good representation of the unsaturated zone in the model. Flow processes in the unsaturated zone have all the typical features of flow in porous media: Processes can have long memory and as observations are scarce, hydraulic model parameters cannot be determined easily. However, they are important for the quality of model predictions. On top of that, the established flow models are highly non-linear. For these reasons, the use of the popular Ensemble Kalman filter as a data assimilation method to estimate state and parameters in unsaturated zone models could be questioned. With respect to the long process memory in the subsurface, it has been suggested that iterative filters and smoothers may be more suitable for parameter estimation in unsaturated media. We test the performance of different iterative filters and smoothers for data assimilation with a focus on parameter updates in the unsaturated zone. In particular we compare the Iterative Ensemble Kalman Filter and Smoother as introduced by Bocquet and Sakov (2013) as well as the Confirming Ensemble Kalman Filter and the modified Restart Ensemble Kalman Filter proposed by Song et al. (2014) to the original Ensemble Kalman Filter (Evensen, 2009). This is done with simple test cases generated numerically. We consider also test examples with layering structure, as a layering structure is often found in natural soils. We assume that observations are water content, obtained from TDR probes or other observation methods sampling relatively small volumes. Particularly in larger data assimilation frameworks, a reasonable balance between computational effort and quality of results has to be found. Therefore, we compare computational costs of the different methods as well

  10. Birth Control Methods

    Science.gov (United States)

    ... Home A-Z Health Topics Birth control methods Birth control methods > A-Z Health Topics Birth control methods ... To receive Publications email updates Enter email Submit Birth control methods Birth control (contraception) is any method, medicine, ...

  11. The clinical method and the scientific method

    Directory of Open Access Journals (Sweden)

    José Arteaga Herrera

    2010-12-01

    Full Text Available This paper is the chapter dedicated to the scientific method and the clinical method in the authors’ Handbook “Teaching of Clinics”. Philosophycal principles of the scientific method and its stages are presented as well as the clinical method as a scientific one and its stages. A relationship between the clinical method and the medical record is established, the role of technology in the clinical method is stated and the most frequent mistakes when applying it in clinical practice are provided. Finally, the teaching of the clinical method and the appropriate settings to do it are discussed.

  12. On a Non-Symmetric Eigenvalue Problem Governing Interior Structural–Acoustic Vibrations

    Directory of Open Access Journals (Sweden)

    Heinrich Voss

    2016-06-01

    Full Text Available Small amplitude vibrations of a structure completely filled with a fluid are considered. Describing the structure by displacements and the fluid by its pressure field, the free vibrations are governed by a non-self-adjoint eigenvalue problem. This survey reports on a framework for taking advantage of the structure of the non-symmetric eigenvalue problem allowing for a variational characterization of its eigenvalues. Structure-preserving iterative projection methods of the the Arnoldi and of the Jacobi–Davidson type and an automated multi-level sub-structuring method are reviewed. The reliability and efficiency of the methods are demonstrated by a numerical example.

  13. 刑法学实务案例教学方式探析%The Application of Case Teaching Method in the Science of Criminal Law

    Institute of Scientific and Technical Information of China (English)

    孟庆华; 王法

    2014-01-01

    Criminal cases should be considered in the selection of typical cases and criminal law practice ,major criminal cases should keep pace with the times and selecting the case should be moderate difficulty and other factors .The undergraduate teaching of criminal law should focus on criminal law theory study ,in order to make the theory of criminal law is more easily accepted by students ,it is necessary to complement by further explanation .Graduate teaching of criminal law without copying USA “case teaching method” and the German “into” teaching method ,no need to restart to explore“complementary teaching method teaching method” and other new , as long as we adhere to the application and improvement of “three three” teaching mode .%刑法学实务案例教学应选择较为典型与重大的刑法实务案例,刑法实务案例应与时俱进,所选案例应当难易适中。本科刑法学教学应把重点放在刑法理论的学习上,而为了使刑法理论更易被学生所接受,就有必要辅之以适当的案例作进一步说明、阐述。研究生刑法学教学既无需照搬美国的“判例教学法”与德国的“归入法”教学方式,也无需重新去探讨“互补式教学法”等新的教学方式,只要进一步坚持适用与完善“三三制”教学方式即可。

  14. An Inexact Halley's Method

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    An inexact Halley's method-Halley-PCG(preconditioned conjugate gradient) method is proposed for solving the systems of linear equations for improved Halley method either by Cholesky factorization exactly or by preconditioned conjugate gradient method approximately. The convergence result is given and the efficiency of the method compared to the improved Halley's method is shown.

  15. TRLAN User Guide

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Kesheng; Simon, H.

    1999-03-09

    TRLAN is a program designed to find a small number of extreme eigenvalues and their corresponding eigenvectors of a real symmetric matrix. Denote the matrix as A, the eigenvalue as {lambda}, and the corresponding eigenvector as x, they are defined by the following equation, Ax = {lambda}x. There are a number of different implementations of the Lanczos algorithm available. Why another one? Our main motivation is to develop a specialized version that only target the case where one wants both eigenvalues and eigenvectors of a large real symmetric eigenvalue problems that can not use the shift-and-invert scheme. In this case the standard non-restarted Lanczos algorithm requires one to store a large number of Lanczos vectors which can cause storage problem and make each iteration of the method very expensive. The underlying algorithm of TRLAN is a dynamic thick-restart Lanczos algorithm. Like all restarted methods, the user can choose how many vectors can be generated at once. Typically, th e user chooses a moderate size so that all Lanczos vectors can be stored in core. This allows the restarted methods to execute efficiently. This implementation of the thick-restart Lanczos method also uses the latest restarting technique, it is very effective in reducing the time required to compute a desired solutions compared to similar restarted Lanczos schemes, e.g., ARPACK.

  16. Identification of solar cell model parameters by combining analytical method with Nelder-Mead simplex method%解析法-Nelder Mead单纯形算法确定太阳电池参数

    Institute of Scientific and Technical Information of China (English)

    高献坤; 姚传安; 高向川; 余泳昌

    2014-01-01

     the initial search point for the NM method. The third phase of A-bcNM is utilizing the NM method as optimizer to minimize the root mean square error between the experimental data and the simulated data, and restart the NM method at the currently observed points several times. The main intention of restarting the NM method is to escape from the local extreme points and further improve the precision of fitting and the quality of parameter solutions. To evaluate the speed of convergence and accuracy of the A-bcNM method presented here, single and double diode models of two typical solar cells were tested. The identification results indicate that the simulation data with the parameters obtained by A-bcNM method are in very good agreement with the experimental data in all cases. Comparing with the best known methods reported in the literature, such as a genetic algorithm (GA), simulated annealing (SA), pattern search (PS), particle swarm optimization (PSO), harmony search (HS), artificial bee swarm optimization (ABSO), improved adaptive differential evolution (IADE), bird mating optimizer (BMO), and repaired adaptive differential evolution (Rcr-IJADE), all cases demonstrate that the A-bcNM method is rather simple, straightforward, computationally efficient and sufficiently accurate for parameter identification of solar cell models. In short, simple concept, easy implementation and high performance are the main advantages of the A-bcNM method, and it is useful for PV systems designers to build an efficient and accurate solar cell system simulator.%光伏发电系统的设计计算、性能评估及优化控制要求快速、准确的确定太阳电池模型参数。针对太阳电池单、双二极管模型参数辨识问题,该文提出一种基于解析法和Nelder Mead单纯形法重启策略的A-bcNM混合算法。先用实测I-V曲线上的部分关键点计算合成参数,再以单二极管模型近似解析式快速定位搜索始点,最

  17. Meshless Methods Coupled with Other Numerical Methods

    Institute of Scientific and Technical Information of China (English)

    Y.T.GU; G.R.LIU

    2005-01-01

    Meshless or mesh-free (or shorten as MFree) methods have been proposed and achieved remarkable progress over the past few years. The idea of combining MFree methods with other existing numerical techniques such as the finite element method (FEM) and the boundary element method (BEM), is naturally of great interest in many practical applications. However, the shape functions used in some MFree methods do not have the Kronecker delta function property. In order to satisfy the combined conditions of displacement compatibility, two numerical techniques, using the hybrid displacement shape function and the modified variational form, are developed and discussed in this paper. In the first technique, the original MFree shape functions are modified to the hybrid forms that possess the Kronecker delta function property. In the second technique, the displacement compatibility is satisfied via a modified variational form based on the Lagrange multiplier method. Formulations of several coupled methods are presented. Numerical examples are presented to demonstrate the effectiveness of the present coupling methods.

  18. From Method to Post Method: A Panacea!

    Science.gov (United States)

    Masouleh, Nima Shakouri

    2012-01-01

    The foundation of language teaching has undergone many changes. The rise and fall of language teaching methods depends upon a variety of factors extrinsic to a method itself and often reflects the influence of profit-seekers and promoters, as well as the forces of the intellectual marketplace. There was always a source of contention among people…

  19. The Multidimensional WKB Method.

    Science.gov (United States)

    Knudson, Stephen K.; Noid, D. W.

    1989-01-01

    Discusses a new method for determining the eigenvalues of the Schroedinger equation when the potential energy function does not have a simple form. Describes the mathematical methods and provides an application. Lists limitations to the method. (MVL)

  20. ANALYSIS OF MULTISCALE METHODS

    Institute of Scientific and Technical Information of China (English)

    Wei-nan E; Ping-bing Ming

    2004-01-01

    The heterogeneous multiscale method gives a general framework for the analysis of multiscale methods. In this paper, we demonstrate this by applying this framework to two canonical problems: The elliptic problem with multiscale coefficients and the quasicontinuum method.

  1. Ensemble Data Mining Methods

    Data.gov (United States)

    National Aeronautics and Space Administration — Ensemble Data Mining Methods, also known as Committee Methods or Model Combiners, are machine learning methods that leverage the power of multiple models to achieve...

  2. Simplifications of CQC method and CCQC method

    Institute of Scientific and Technical Information of China (English)

    Yu Ruifang; Zhou Xiyuan

    2007-01-01

    The response-spectrum mode superposition method is widely used for seismic response analyses of linear systems. In using this method, the complete quadratic combination (CQC) is adopted for classically damped linear systems and the complex complete quadratic combination (CCQC) formula is adopted for non-classically damped linear systems.However, in both cases, the calculation of seismic response analyses is very time consuming. In this paper, the variation of the modal correlation coefficients of displacement, velocity and displacement-velocity with frequency and damping ratios of two modes of interest are studied, Moreover, the calculation errors generated by using CQC and square-root-of-the-sum-of-the-squares (SRSS) methods (or CCQC and CSRSS methods) for different damping combinations are compared. In these analyses,some boundary lines for classically and non-classically damped systems are plotted to distinguish the allowed minimum frequency ratio at given geometric mean of the damping ratios of both modes if their relativity is neglected. Furthermore,the simplified method, which is a special mode quadratic combination method considering only relativity of adjacent modes in CQC method and named simplified CQC or partial quadratic combination (PQC) method for classically damped linear system, is proposed to improve computational efficiency, and the criterion for determination of how many correlated modes should be adopted is proposed. Similarly, the simplified CCQC or complex partial quadratic combination (CPQC) method for the non-classically damped linear system and the corresponding criterion are also deduced. Finally, a numerical example is given to illustrate the applicability, computational accuracy and efficiency of the PQC and CPQC methods.

  3. Krylov solvers for linear algebraic systems

    CERN Document Server

    Broyden, Charles George

    2004-01-01

    The first four chapters of this book give a comprehensive and unified theory of the Krylov methods. Many of these are shown to be particular examples ofthe block conjugate-gradient algorithm and it is this observation thatpermits the unification of the theory. The two major sub-classes of thosemethods, the Lanczos and the Hestenes-Stiefel, are developed in parallel asnatural generalisations of the Orthodir (GCR) and Orthomin algorithms. Theseare themselves based on Arnoldi's algorithm and a generalised Gram-Schmidtalgorithm and their properties, in particular their stability properties,are det

  4. Simulations using meshfree methods

    CERN Document Server

    P, Kirana Kumara

    2015-01-01

    In this paper, attempt is made to solve a few problems using the Polynomial Point Collocation Method (PPCM), the Radial Point Collocation Method (RPCM), Smoothed Particle Hydrodynamics (SPH), and the Finite Point Method (FPM). A few observations on the accuracy of these methods are recorded. All the simulations in this paper are three dimensional linear elastostatic simulations, without accounting for body forces.

  5. Numerical Methods for Multilattices

    CERN Document Server

    Abdulle, Assyr; Shapeev, Alexander V

    2011-01-01

    Among the efficient numerical methods based on atomistic models, the quasicontinuum (QC) method has attracted growing interest in recent years. The QC method was first developed for crystalline materials with Bravais lattice and was later extended to multilattices (Tadmor et al, 1999). Another existing numerical approach to modeling multilattices is homogenization. In the present paper we review the existing numerical methods for multilattices and propose another concurrent macro-to-micro method in the homogenization framework. We give a unified mathematical formulation of the new and the existing methods and show their equivalence. We then consider extensions of the proposed method to time-dependent problems and to random materials.

  6. Inflow Turbulence Generation Methods

    Science.gov (United States)

    Wu, Xiaohua

    2017-01-01

    Research activities on inflow turbulence generation methods have been vigorous over the past quarter century, accompanying advances in eddy-resolving computations of spatially developing turbulent flows with direct numerical simulation, large-eddy simulation (LES), and hybrid Reynolds-averaged Navier-Stokes–LES. The weak recycling method, rooted in scaling arguments on the canonical incompressible boundary layer, has been applied to supersonic boundary layer, rough surface boundary layer, and microscale urban canopy LES coupled with mesoscale numerical weather forecasting. Synthetic methods, originating from analytical approximation to homogeneous isotropic turbulence, have branched out into several robust methods, including the synthetic random Fourier method, synthetic digital filtering method, synthetic coherent eddy method, and synthetic volume forcing method. This article reviews major progress in inflow turbulence generation methods with an emphasis on fundamental ideas, key milestones, representative applications, and critical issues. Directions for future research in the field are also highlighted.

  7. Advanced differential quadrature methods

    CERN Document Server

    Zong, Zhi

    2009-01-01

    Modern Tools to Perform Numerical DifferentiationThe original direct differential quadrature (DQ) method has been known to fail for problems with strong nonlinearity and material discontinuity as well as for problems involving singularity, irregularity, and multiple scales. But now researchers in applied mathematics, computational mechanics, and engineering have developed a range of innovative DQ-based methods to overcome these shortcomings. Advanced Differential Quadrature Methods explores new DQ methods and uses these methods to solve problems beyond the capabilities of the direct DQ method.After a basic introduction to the direct DQ method, the book presents a number of DQ methods, including complex DQ, triangular DQ, multi-scale DQ, variable order DQ, multi-domain DQ, and localized DQ. It also provides a mathematical compendium that summarizes Gauss elimination, the Runge-Kutta method, complex analysis, and more. The final chapter contains three codes written in the FORTRAN language, enabling readers to q...

  8. Consumer Behavior Research Methods

    DEFF Research Database (Denmark)

    Chrysochou, Polymeros

    2017-01-01

    emphasizes the discussion of primary research methods. Based on the nature of the data primary research methods are further distinguished into qualitative and quantitative. The chapter describes the most important and popular qualitative and quantitative methods. It concludes with an overall evaluation......This chapter starts by distinguishing consumer behavior research methods based on the type of data used, being either secondary or primary. Most consumer behavior research studies phenomena that require researchers to enter the field and collect data on their own, and therefore the chapter...... of the methods and how to improve quality in consumer behavior research methods....

  9. Quality Control Analytical Methods: Method Validation.

    Science.gov (United States)

    Klang, Mark G; Williams, LaVonn A

    2016-01-01

    To properly determine the accuracy of a pharmaceutical product or compounded preparation, tests must be designed specifically for that evaluation. The procedures selected must be verified through a process referred to as method validation, an integral part of any good analytical practice. The results from a method validation procedure can be used to judge the quality, reliability, and consistency of analytical results. The purpose of this article is to deliver the message of the importance of validation of a pharmaceutical product or compounded preparation and to briefly discuss the results of a lack of such validation. Copyright© by International Journal of Pharmaceutical Compounding, Inc.

  10. Applied Bayesian Hierarchical Methods

    CERN Document Server

    Congdon, Peter D

    2010-01-01

    Bayesian methods facilitate the analysis of complex models and data structures. Emphasizing data applications, alternative modeling specifications, and computer implementation, this book provides a practical overview of methods for Bayesian analysis of hierarchical models.

  11. Dissolution Methods Database

    Data.gov (United States)

    U.S. Department of Health & Human Services — For a drug product that does not have a dissolution test method in the United States Pharmacopeia (USP), the FDA Dissolution Methods Database provides information on...

  12. Dissolution Methods Database

    Data.gov (United States)

    U.S. Department of Health & Human Services — For a drug product that does not have a dissolution test method in the United States Pharmacopeia (USP), the FDA Dissolution Methods Database provides information on...

  13. Simulated floating zone method

    OpenAIRE

    Ozawa, Ryo; Kato, Yasuyuki; Motome, Yukitoshi

    2016-01-01

    This paper provides the simulated floating zone (SFZ) method that is an efficient simulation technique to obtain thermal equilibrium states, especially useful when domain formation prevents the system from reaching a spatially-uniform stable state. In the SFZ method, the system is heated up locally, and the heated region is steadily shifted, similar to the floating zone method for growing a single crystal with less lattice defect and impurity in experiments. We demonstrate that the SFZ method...

  14. Improved method to determine the molar volume and compositions of the NaCl-H2O-CO2 system inclusion

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    On the basis of Parry’s method (1986), an improved method was established to determine the molar volume (Vm) and compositions (X) of the NaCl-H2O-CO2 (NHC) system inclusion. To use this method, the determination of Vm-X only requires three microthermometric data of a NHC inclusion: partial homog-enization temperature (Th ,CO2), salinity (S) and total homogenization temperature (Th). Theoretically, four associated equations are needed containing four unknown parameters: X CO2, XNaCl, Vm and F (volume fraction of CO2 phase in total inclusion when occurring partial homogenization). When they are released, the Vm-X are determined. The former three equations, only correlated with Th ,CO2, S and F, have simplified expressions:XCO2=f1(Th,CO2,S,F),XNaCl=f2(Th,CO2,S,F),Vm=f3(Th,CO2,S,F). The last one is the thermodynamic relationship of X CO2, XNaCl, Vm and Th:f4(XCO2,XNaCl,Vm,Th)=0.Since the above four associated equations are complicated, it is necessary to adopt iterative technique to release them. The technique can be described by:(i) Freely input a F value (0≤F≤1),with Th ,CO2 and S, into the former three equations. As a result,X CO 2,XNaCl and the molar volume value recorded as Vm1 are derived. (ii) Input the X CO2 and XNaCl gotten in the step above into the last equation, and another molar volume value recorded as Vm2 is determined. (iii) If Vm1 is unequal to Vm2, the calculation will be restarted from “(i)”. The iteration is completed until Vm1 is equal to Vm2, which means that the four associated equations are released. Compared to Parry’s (1986) solution method, the improved method is more convenient to use, as well as more accurate to determine X CO 2. It is available for a NHC inlusion whose partial homogenization temperature is higher than clatherate melting temperature and there are no solid salt crystals in the inclusion at parital homogenization.

  15. Mixed methods research.

    Science.gov (United States)

    Halcomb, Elizabeth; Hickman, Louise

    2015-04-08

    Mixed methods research involves the use of qualitative and quantitative data in a single research project. It represents an alternative methodological approach, combining qualitative and quantitative research approaches, which enables nurse researchers to explore complex phenomena in detail. This article provides a practical overview of mixed methods research and its application in nursing, to guide the novice researcher considering a mixed methods research project.

  16. Geobacteraceae strains and methods

    Science.gov (United States)

    Lovley, Derek R.; Nevin, Kelly P.; Yi, Hana

    2015-07-07

    Embodiments of the present invention provide a method of producing genetically modified strains of electricigenic microbes that are specifically adapted for the production of electrical current in microbial fuel cells, as well as strains produced by such methods and fuel cells using such strains. In preferred embodiments, the present invention provides genetically modified strains of Geobacter sulfurreducens and methods of using such strains.

  17. Numerical methods using Matlab

    CERN Document Server

    Gupta, Abhishek

    2015-01-01

    Numerical Methods with MATLAB provides a highly-practical reference work to assist anyone working with numerical methods. A wide range of techniques are introduced, their merits discussed and fully working MATLAB code samples supplied to demonstrate how they can be coded and applied. Numerical methods have wide applicability across many scientific, mathematical, and engineering disciplines and are most often employed in situations where working out an exact answer to the problem by another method is impractical. Numerical Methods with MATLAB presents each topic in a concise and readable

  18. The Generalized Sturmian Method

    DEFF Research Database (Denmark)

    Avery, James Emil

    2011-01-01

    generations of researchers were left to work out how to achieve this ambitious goal for molecular systems of ever-increasing size. This book focuses on non-mainstream methods to solve the molecular electronic Schrödinger equation. Each method is based on a set of core ideas and this volume aims to explain...... these ideas clearly so that they become more accessible. By bringing together these non-standard methods, the book intends to inspire graduate students, postdoctoral researchers and academics to think of novel approaches. Is there a method out there that we have not thought of yet? Can we design a new method...

  19. Mimetic discretization methods

    CERN Document Server

    Castillo, Jose E

    2013-01-01

    To help solve physical and engineering problems, mimetic or compatible algebraic discretization methods employ discrete constructs to mimic the continuous identities and theorems found in vector calculus. Mimetic Discretization Methods focuses on the recent mimetic discretization method co-developed by the first author. Based on the Castillo-Grone operators, this simple mimetic discretization method is invariably valid for spatial dimensions no greater than three. The book also presents a numerical method for obtaining corresponding discrete operators that mimic the continuum differential and

  20. Methods for assessing geodiversity

    Science.gov (United States)

    Zwoliński, Zbigniew; Najwer, Alicja; Giardino, Marco

    2017-04-01

    The accepted systematics of geodiversity assessment methods will be presented in three categories: qualitative, quantitative and qualitative-quantitative. Qualitative methods are usually descriptive methods that are suited to nominal and ordinal data. Quantitative methods use a different set of parameters and indicators to determine the characteristics of geodiversity in the area being researched. Qualitative-quantitative methods are a good combination of the collection of quantitative data (i.e. digital) and cause-effect data (i.e. relational and explanatory). It seems that at the current stage of the development of geodiversity research methods, qualitative-quantitative methods are the most advanced and best assess the geodiversity of the study area. Their particular advantage is the integration of data from different sources and with different substantive content. Among the distinguishing features of the quantitative and qualitative-quantitative methods for assessing geodiversity are their wide use within geographic information systems, both at the stage of data collection and data integration, as well as numerical processing and their presentation. The unresolved problem for these methods, however, is the possibility of their validation. It seems that currently the best method of validation is direct filed confrontation. Looking to the next few years, the development of qualitative-quantitative methods connected with cognitive issues should be expected, oriented towards ontology and the Semantic Web.

  1. Design Methods in Practice

    DEFF Research Database (Denmark)

    Jensen, Torben Elgaard; Andreasen, Mogens Myrup

    2010-01-01

    The paper challenges the dominant and widespread view that a good design method will guarantee a systematic approach as well as certain results. First, it explores the substantial differences between on the one hand the conception of methods implied in Pahl & Beitz’s widely recognized text book...... subject to change; The goals of methods are less stable than assumed. The paper finally suggests that ethnomethodology and similar approaches direct our attention to the fact that method use is always a situated and socially interactive affair. It is crucial to attend to these dimensions of method use...... on engineering design, and on the other hand the understanding of method use, which has emerged from micro-sociological studies of practice (ethnomethodology). Second, it reviews a number of case studies conducted by engineering students, who were instructed to investigate the actual use of design methods...

  2. Consensus theoretic classification methods

    Science.gov (United States)

    Benediktsson, Jon A.; Swain, Philip H.

    1992-01-01

    Consensus theory is adopted as a means of classifying geographic data from multiple sources. The foundations and usefulness of different consensus theoretic methods are discussed in conjunction with pattern recognition. Weight selections for different data sources are considered and modeling of non-Gaussian data is investigated. The application of consensus theory in pattern recognition is tested on two data sets: 1) multisource remote sensing and geographic data and 2) very-high-dimensional remote sensing data. The results obtained using consensus theoretic methods are found to compare favorably with those obtained using well-known pattern recognition methods. The consensus theoretic methods can be applied in cases where the Gaussian maximum likelihood method cannot. Also, the consensus theoretic methods are computationally less demanding than the Gaussian maximum likelihood method and provide a means for weighting data sources differently.

  3. The Implementation of Hard-Disk Protection Method Based on Disk Filter Driver

    OpenAIRE

    Yangwu Liu; Xisan Wei

    2013-01-01

    In this paper, it analyzes the working mechanism for the hard disk protection based on the current disk filter driver. The core ideology of the mechanism is to redirect the I/O request packet to the disk operation and to restore data automatically after restart the system in the case of transparent operating system to its upper storey. Also, it specifically analyzes the safety trouble by new virus, like the emerging virus, which can penetrate through the filter driver and results the failure ...

  4. Methods of Software Verification

    Directory of Open Access Journals (Sweden)

    R. E. Gurin

    2015-01-01

    Full Text Available This article is devoted to the problem of software verification (SW. Methods of software verification designed to check the software for compliance with the stated requirements such as correctness, system security and system adaptability to small changes in the environment, portability and compatibility, etc. These are various methods both by the operation process and by the way of achieving result. The article describes the static and dynamic methods of software verification and paid attention to the method of symbolic execution. In its review of static analysis are discussed and described the deductive method, and methods for testing the model. A relevant issue of the pros and cons of a particular method is emphasized. The article considers classification of test techniques for each method. In this paper we present and analyze the characteristics and mechanisms of the static analysis of dependencies, as well as their views, which can reduce the number of false positives in situations where the current state of the program combines two or more states obtained both in different paths of execution and in working with multiple object values. Dependences connect various types of software objects: single variables, the elements of composite variables (structure fields, array elements, the size of the heap areas, the length of lines, the number of initialized array elements in the verification code using static methods. The article pays attention to the identification of dependencies within the framework of the abstract interpretation, as well as gives an overview and analysis of the inference tools.Methods of dynamic analysis such as testing, monitoring and profiling are presented and analyzed. Also some kinds of tools are considered which can be applied to the software when using the methods of dynamic analysis. Based on the work a conclusion is drawn, which describes the most relevant problems of analysis techniques, methods of their solutions and

  5. Performative Schizoid Method

    DEFF Research Database (Denmark)

    Svabo, Connie

    2016-01-01

    A performative schizoid method is developed as a method contribution to performance as research. The method is inspired by contemporary research in the human and social sciences urging experimentation and researcher engagement with creative and artistic practice. In the article, the method...... is presented and an example is provided of a first exploratory engagement with it. The method is used in a specific project Becoming Iris, making inquiry into arts-based knowledge creation during a three month visiting scholarship at a small, independent visual art academy. Using the performative schizoid...... method in Becoming Iris results in four audio-visual and performance-based productions, centered on an emergent theme of the scholartist as a bird in borrowed feathers. Interestingly, the moral lesson of the fable about the vain jackdaw, who dresses in borrowed peacock feathers and becomes a castout...

  6. Exoplanet Detection Methods

    CERN Document Server

    Wright, Jason T

    2012-01-01

    This chapter reviews various methods of detecting planetary companions to stars from an observational perspective, focusing on radial velocities, astrometry, direct imaging, transits, and gravitational microlensing. For each method, this chapter first derives or summarizes the basic observable phenomena that are used to infer the ex- istence of planetary companions, as well as the physical properties of the planets and host stars that can be derived from the measurement of these signals. This chapter then outlines the general experimental requirements to robustly detect the signals us- ing each method, by comparing their magnitude to the typical sources of measurement uncertainty. This chapter goes on to compare the various methods to each other by outlining the regions of planet and host star parameter space where each method is most sensitive, stressing the complementarity of the ensemble of the methods at our disposal. Finally, there is a brief review of the history of the young exoplanet field, from the f...

  7. Phenomenographic Research Method

    Directory of Open Access Journals (Sweden)

    Erdem ÇEKMEZ

    2012-12-01

    Full Text Available Phenomenography, an approach to educational research, emerged from the studies carried out by Ference Marton and his colleagues at the University of Göteborg, Sweden, in the early 1970s. Phenomenography is the empirical study of the different ways in which people experience, perceive, apprehend, understand, conceptualize various phenomena in the world around them. Not only this method has been used much in educational researches in Turkey, but also the books about research methods do not provide detailed information about this method in details. This study explains the aim, characteristics, historical background and how to ensure the generalization, validity and reliability of phenomenographic research outcomes, besides mentions to the studies in which phenomenographic research method was used. In addition, the differences and similarities between this method and methods similar to phenomenology are explained.

  8. The Schwinger Variational Method

    Science.gov (United States)

    Huo, Winifred M.

    1995-01-01

    Variational methods have proven invaluable in theoretical physics and chemistry, both for bound state problems and for the study of collision phenomena. For collisional problems they can be grouped into two types: those based on the Schroedinger equation and those based on the Lippmann-Schwinger equation. The application of the Schwinger variational (SV) method to e-molecule collisions and photoionization has been reviewed previously. The present chapter discusses the implementation of the SV method as applied to e-molecule collisions.

  9. Applied iterative methods

    CERN Document Server

    Hageman, Louis A

    2004-01-01

    This graduate-level text examines the practical use of iterative methods in solving large, sparse systems of linear algebraic equations and in resolving multidimensional boundary-value problems. Assuming minimal mathematical background, it profiles the relative merits of several general iterative procedures. Topics include polynomial acceleration of basic iterative methods, Chebyshev and conjugate gradient acceleration procedures applicable to partitioning the linear system into a "red/black" block form, adaptive computational algorithms for the successive overrelaxation (SOR) method, and comp

  10. Well testing: interpretation methods

    Energy Technology Data Exchange (ETDEWEB)

    Bourdarot, G. [Elf Aquitaine, 92 - Courbevoie (France)

    1998-12-31

    This book presents the different methods to use for interpreting well tests: conventional methods, type curves, derivative, according to the type of reservoir limits (faults, channels, secant faults, constant pressure limits, closed reservoir) and the well configuration (partial penetration, inclined, fractured, horizontal or injection well). It indicates the method to be used in the case of more complex reservoirs (fissured reservoirs, two-layered reservoirs), interference tests or pulse tests and when fluid produced is gas or polyphasic. (authors) 60 refs.

  11. Well testing: interpretation methods

    Energy Technology Data Exchange (ETDEWEB)

    Bourdarot, G. (Elf Aquitaine, 92 - Courbevoie (France))

    1998-01-01

    This book presents the different methods to use for interpreting well tests: conventional methods, type curves, derivative, according to the type of reservoir limits (faults, channels, secant faults, constant pressure limits, closed reservoir) and the well configuration (partial penetration, inclined, fractured, horizontal or injection well). It indicates the method to be used in the case of more complex reservoirs (fissured reservoirs, two-layered reservoirs), interference tests or pulse tests and when fluid produced is gas or polyphasic. (authors) 60 refs.

  12. The Box Method

    DEFF Research Database (Denmark)

    Nielsen, Peter Vilhelm

    The velocity level in a room ventilated by jet ventilation is strongly influenced by the supply conditions. The momentum flow in the supply jets controls the air movement in the room and, therefore, it is very important that the inlet conditions and the numerical method can generate a satisfactor...... description of this momentum flow. The Box Method is a practical method for the description of an Air Terminal Device which will save grid points and ensure the right level of the momentum flow....

  13. Methods of inventory control.

    Science.gov (United States)

    Lindley, C; Mackowiak, J

    1985-01-01

    Various methods for controlling inventory are described, and the advantages and disadvantages of each are discussed. The open-to-buy (OTB) budget method limits purchases to a specific amount of funds available for purchasing pharmaceuticals during a specified period. The emphasis of the OTB method is financial control of the pharmacy inventory. Although it is useful in monitoring and adjusting the dollar value of the inventory, it should be combined with other methods for a total inventory control system. The primary emphasis of the short-list method is to provide accurate and timely inventory information to the person responsible for order placement. The short list identifies the items that are in short supply. It is the most common feedback and control mechanism in use, but it is best suited for settings where duplicate or reserve stock is maintained and monitored by more rigorous methods. The main objective of the minimum and maximum method is to determine when and how much to order of each item. It also provides limited dollar control. The major disadvantage of this method is the time it requires to establish the minimum and maximum levels and to update them regularly to reflect changes in demand. The stock record card method is used to record information on the movement of goods in and out of the storage area. Stock cards can also be used to monitor inventory levels and facilitate order initiation. It is probably the optimum method to be used alone. The most effective system of inventory control is one employing a combination of these methods tailored to meet the institution's needs and available resources.

  14. Methods for data classification

    Science.gov (United States)

    Garrity, George; Lilburn, Timothy G.

    2011-10-11

    The present invention provides methods for classifying data and uncovering and correcting annotation errors. In particular, the present invention provides a self-organizing, self-correcting algorithm for use in classifying data. Additionally, the present invention provides a method for classifying biological taxa.

  15. DISCOURSE ON METHODS.

    Science.gov (United States)

    BOUCHER, JOHN G.

    THE AUTHOR STATES THAT BEFORE PRESENT FOREIGN LANGUAGE TEACHING METHODS CAN BE DISCUSSED INTELLIGENTLY, THE RESEARCH IN PSYCHOLOGY AND LINGUISTICS WHICH HAS INFLUENCED THE DEVELOPMENT OF THESE METHODS MUST BE CONSIDERED. MANY FOREIGN LANGUAGE TEACHERS WERE BEGINNING TO FEEL COMFORTABLE WITH THE AUDIOLINGUAL APPROACH WHEN NOAM CHOMSKY, IN HIS 1966…

  16. Noise-Measuring Method

    DEFF Research Database (Denmark)

    Diamond, J. M.

    1965-01-01

    A noise-measuring method based on the use of a calibrated noise generator and an output meter with a special scale is described. The method eliminates the effect of noise contributions occurring in the circuits following the device under test....

  17. Method of forming nanodielectrics

    Science.gov (United States)

    Tuncer, Enis [Knoxville, TN; Polyzos, Georgios [Oak Ridge, TN

    2014-01-07

    A method of making a nanoparticle filled dielectric material. The method includes mixing nanoparticle precursors with a polymer material and reacting the nanoparticle mixed with the polymer material to form nanoparticles dispersed within the polymer material to form a dielectric composite.

  18. Soybean allergen detection methods

    DEFF Research Database (Denmark)

    Pedersen, Mona H; Holzhauser, Thomas; Bisson, Caroline

    2008-01-01

    Soybean containing products are widely consumed, thus reliable methods for detection of soy in foods are needed in order to make appropriate risk assessment studies to adequately protect soy allergic patients. Six methods were compared using eight food products with a declared content of soy...

  19. The Method of Archimedes.

    Science.gov (United States)

    Del Grande, John

    1993-01-01

    Describes the method that Archimedes utilized to calculate the volumes of spheres and other solids. The method found the volume of a sphere by comparing the mass of parallel slices of a sphere and a cone with that of a cylinder of known mass. (MDH)

  20. Research Methods in Education

    Science.gov (United States)

    Check, Joseph; Schutt, Russell K.

    2011-01-01

    "Research Methods in Education" introduces research methods as an integrated set of techniques for investigating questions about the educational world. This lively, innovative text helps students connect technique and substance, appreciate the value of both qualitative and quantitative methodologies, and make ethical research decisions.…

  1. METHOD FOR MAKING CHEESE

    DEFF Research Database (Denmark)

    2010-01-01

    The present invention relates to a method for making Cheddar type and Continental type cheese with an adjunct culture comprising a Lactobacillus helveticus strain.......The present invention relates to a method for making Cheddar type and Continental type cheese with an adjunct culture comprising a Lactobacillus helveticus strain....

  2. Improved nonlinear prediction method

    Science.gov (United States)

    Adenan, Nur Hamiza; Md Noorani, Mohd Salmi

    2014-06-01

    The analysis and prediction of time series data have been addressed by researchers. Many techniques have been developed to be applied in various areas, such as weather forecasting, financial markets and hydrological phenomena involving data that are contaminated by noise. Therefore, various techniques to improve the method have been introduced to analyze and predict time series data. In respect of the importance of analysis and the accuracy of the prediction result, a study was undertaken to test the effectiveness of the improved nonlinear prediction method for data that contain noise. The improved nonlinear prediction method involves the formation of composite serial data based on the successive differences of the time series. Then, the phase space reconstruction was performed on the composite data (one-dimensional) to reconstruct a number of space dimensions. Finally the local linear approximation method was employed to make a prediction based on the phase space. This improved method was tested with data series Logistics that contain 0%, 5%, 10%, 20% and 30% of noise. The results show that by using the improved method, the predictions were found to be in close agreement with the observed ones. The correlation coefficient was close to one when the improved method was applied on data with up to 10% noise. Thus, an improvement to analyze data with noise without involving any noise reduction method was introduced to predict the time series data.

  3. Data center cooling method

    Energy Technology Data Exchange (ETDEWEB)

    Chainer, Timothy J.; Dang, Hien P.; Parida, Pritish R.; Schultz, Mark D.; Sharma, Arun

    2015-08-11

    A method aspect for removing heat from a data center may use liquid coolant cooled without vapor compression refrigeration on a liquid cooled information technology equipment rack. The method may also include regulating liquid coolant flow to the data center through a range of liquid coolant flow values with a controller-apparatus based upon information technology equipment temperature threshold of the data center.

  4. Studying Aid: Some Methods

    NARCIS (Netherlands)

    D.R. Gasper (Des)

    2003-01-01

    textabstractINVESTIGATING IDEAS, IDEOLOGIES AND PRACTICES This paper presents some methods for trying to make sense of international aid and of its study.1 Some of the methods may be deemed ethnographic; the others are important partners to them, but rather different. In the course of discussing q

  5. Research Methods in Education

    Science.gov (United States)

    Check, Joseph; Schutt, Russell K.

    2011-01-01

    "Research Methods in Education" introduces research methods as an integrated set of techniques for investigating questions about the educational world. This lively, innovative text helps students connect technique and substance, appreciate the value of both qualitative and quantitative methodologies, and make ethical research decisions.…

  6. METHODS OF MAGNETOTELLURIC ANALYSIS

    Science.gov (United States)

    Magnetotelluric prospecting is a method of geophysical exploration that makes use of the fluctuations in the natural electric and magnetic fields...function of the conductivity structure of the earth’s substrata. This report describes some new methods for analyzing and interpreting magnetotelluric

  7. Methods in Modern Biophysics

    CERN Document Server

    Nölting, Bengt

    2006-01-01

    Incorporating recent dramatic advances, this textbook presents a fresh and timely introduction to modern biophysical methods. An array of new, faster and higher-power biophysical methods now enables scientists to examine the mysteries of life at a molecular level. This innovative text surveys and explains the ten key biophysical methods, including those related to biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobility spectrometry, mass spectrometry, proteomics, and protein folding and structure. Incorporating much information previously unavailable in tutorial form, Nölting employs worked examples and 267 illustrations to fully detail the techniques and their underlying mechanisms. Methods in Modern Biophysics is written for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in biophysics, biochemistry and related fields. Special features in the 2nd edition: • Illustrates the high-resolution methods for ultrashort-living protei...

  8. Adaptive method of lines

    CERN Document Server

    Saucez, Ph

    2001-01-01

    The general Method of Lines (MOL) procedure provides a flexible format for the solution of all the major classes of partial differential equations (PDEs) and is particularly well suited to evolutionary, nonlinear wave PDEs. Despite its utility, however, there are relatively few texts that explore it at a more advanced level and reflect the method''s current state of development.Written by distinguished researchers in the field, Adaptive Method of Lines reflects the diversity of techniques and applications related to the MOL. Most of its chapters focus on a particular application but also provide a discussion of underlying philosophy and technique. Particular attention is paid to the concept of both temporal and spatial adaptivity in solving time-dependent PDEs. Many important ideas and methods are introduced, including moving grids and grid refinement, static and dynamic gridding, the equidistribution principle and the concept of a monitor function, the minimization of a functional, and the moving finite elem...

  9. Fast Distributed Gradient Methods

    CERN Document Server

    Jakovetic, Dusan; Moura, Jose M F

    2011-01-01

    The paper proposes new fast distributed optimization gradient methods and proves convergence to the exact solution at rate O(\\log k/k), much faster than existing distributed optimization (sub)gradient methods with convergence O(1/\\sqrt{k}), while incurring practically no additional communication nor computation cost overhead per iteration. We achieve this for convex (with at least one strongly convex,) coercive, three times differentiable and with Lipschitz continuous first derivative (private) cost functions. Our work recovers for distributed optimization similar convergence rate gains obtained by centralized Nesterov gradient and fast iterative shrinkage-thresholding algorithm (FISTA) methods over ordinary centralized gradient methods. We also present a constant step size distributed fast gradient algorithm for composite non-differentiable costs. A simulation illustrates the effectiveness of our distributed methods.

  10. Cooperative method development

    DEFF Research Database (Denmark)

    Dittrich, Yvonne; Rönkkö, Kari; Eriksson, Jeanette;

    2008-01-01

    research is not easily combined with the improvement orientation of an engineering discipline. During the last 6 years, we have applied an approach we call `cooperative method development', which combines qualitative social science fieldwork, with problem-oriented method, technique and process improvement....... The action research based approach focusing on shop floor software development practices allows an understanding of how contextual contingencies influence the deployment and applicability of methods, processes and techniques. This article summarizes the experiences and discusses the further development......The development of methods tools and process improvements is best to be based on the understanding of the development practice to be supported. Qualitative research has been proposed as a method for understanding the social and cooperative aspects of software development. However, qualitative...

  11. Engaging with mobile methods

    DEFF Research Database (Denmark)

    Jensen, Martin Trandberg

    2014-01-01

    This chapter showcases how mobile methods are more than calibrated techniques awaiting application by tourism researchers, but productive in the enactment of the mobile (Law and Urry, 2004). Drawing upon recent findings deriving from a PhD course on mobility and mobile methods it reveals...... the conceptual ambiguousness of the term ‘mobile methods’. In order to explore this ambiguousness the chapter provides a number of examples deriving from tourism research, to explore how mobile methods are always entangled in ideologies, predispositions, conventions and practice-realities. Accordingly......, the engagements with methods are acknowledged to be always political and contextual, reminding us to avoid essentialist discussions regarding research methods. Finally, the chapter draws on recent fieldwork to extend developments in mobilities-oriented tourism research, by employing auto-ethnography to call...

  12. 78 FR 34639 - Supplemental Final Environmental Impact Statement for the Restart of Healy Power Plant Unit #2

    Science.gov (United States)

    2013-06-10

    ... (MW) coal-fired boiler that has been owned and operated by Golden Valley Electric Association (GVEA) since 1967. Healy Unit 2 is a 50 MW coal-fired steam generator owned by AIDEA, which underwent...

  13. 40 CFR 60.2850 - What must I do if I close my air curtain incinerator and then restart it?

    Science.gov (United States)

    2010-07-01

    ... Emissions Guidelines and Compliance Times for Commercial and Industrial Solid Waste Incineration Units that... final compliance date, you must complete emission control retrofits and meet the emission limitations...

  14. 40 CFR 60.2610 - What must I do if I close my CISWI unit and then restart it?

    Science.gov (United States)

    2010-07-01

    ... must complete emission control retrofits and meet the emission limitations and operating limits on the... (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emissions Guidelines and Compliance Times for Commercial and Industrial Solid Waste Incineration Units that...

  15. Refractive error change and vision improvement in moderate to severe hyperopic amblyopia after spectacle correction: Restarting the emmetropization process?

    Science.gov (United States)

    Chang, Ji Woong

    2017-01-01

    The aims of the study were to develop guidelines for prescribing spectacles for patients with moderate to severe hyperopic amblyopia and to demonstrate how emmetropization progresses. Children with hyperopic amblyopia who had a spherical equivalent of ≥ +4.0 diopters (D) or more were included, while those who had astigmatism of > 2.0 D or anisometropia of > 2.0 D were excluded. The patients were divided into a full correction group and an under-correction group according to the amount of hyperopia correction applied. The under-correction group was further subdivided into a fixed under-correction group and a post-cycloplegic refraction (PCR) under-correction group. The duration of amblyopia treatment and changes in initial hyperopia were compared between the groups. In total, 76 eyes of 38 patients were analyzed in this study. The full correction group and under-correction group were subjected to 5.5 months and 5.9 months of amblyopia treatment, respectively (P = 0.570). However, the PCR under-correction group showed more rapid improvement (2.9 months; P = 0.001). In the under-correction group, initial hyperopia was decreased by -0.28 D and -0.49 D at 6 months and 12 months, respectively, after initial cycloplegic refraction. Moreover, the amount of hyperopia under-correction was correlated with the amount of hyperopia reduction (P = 0.010). The under-correction of moderate to severe hyperopic amblyopia has beneficial effects for treating amblyopia and activating emmetropization. PCR under-correction can more rapidly improve visual acuity, while both fixed under-correction and PCR under-correction can induce emmetropization and effectively reduce initial hyperopia.

  16. Using Nature-Based Rehabilitation to Restart a Stalled Process of Rehabilitation in Individuals with Stress-Related Mental Illness

    Directory of Open Access Journals (Sweden)

    Eva Sahlin

    2015-02-01

    Full Text Available After a period of decrease, sick leave in Sweden due to psychiatric diagnoses is on the increase. The lack of established rehabilitation programmes for patients with stress-related mental disorders (SRMD has opened up for the use of garden/nature in a multimodal rehabilitation context (Nature-Based Rehabilitation, NBR. Region Västra Götaland (VGR started an NBR to offer additional rehabilitation for its employees on long-term sick leave due to SRMD, where initial care had not been sufficient. The aim was to explore whether the mental health and well-being of NBR participants had improved at the end of the NBR and at three follow-ups, and to explore the development of sick leave and health care utilization according to the NBR model (n = 57 and an occupational health service (OHS model (n = 45. Self-assessment instruments for measuring burnout, depression, anxiety and wellbeing, and data from regional and national registers were used. Results showed decreased scores on burnout, depression and anxiety, and increased well-being scores and significantly reduced health care utilization in the NBR group. A large movement from ordinary sickness benefit to rehabilitation benefit was observed, which was not observed in the OHS group. The two groups were in different rehabilitation phases, which limited comparisons. The results point to beneficial effects of using NBR for this patient group and for enhancing a stalled rehabilitation process.

  17. The final collimator has been installed ready for the LHC restart (phase 1 of the LHC collimator project)

    CERN Multimedia

    CERN audiovisual service

    2009-01-01

    The collimators are installed around the LHC ring and the transfer lines to absorb ‘stray’ particles that have spread out, forming a halo around the beam. It is important to absorb this halo to protect the rest of the machine from damage, in particular the superconducting magnets, where any slight heating by the ‘stray particles’ could cause a magnet quench. The one-meter long collimators absorb the particles in the halo by closing a set of ‘jaws’ of various materials around the beam; the most robust collimators use fiber-reinforced graphite. Before the start-up last year, 88 collimators were installed. The unforeseen shutdown caused by the incident in Sector 3-4, allowed the collimator team to continue with the final 20 collimators necessary to maximize the LHC intensity and luminosity reach with the phase 1 collimation system. This marks the end of 6.5 years of hard work since the project began

  18. Edward Lucas: Venemaa loodab suhete "restart´i" teha ka Balti riikidega / Edward Lucas ; intervjueerinud Argo Ideon

    Index Scriptorium Estoniae

    Lucas, Edward

    2010-01-01

    Eesti-Vene suhete arengust, Eesti sisepoliitikast, liitumisest euroga, riigieelarve kärbetest, Euroopa riikide suhtumisest Eestis toimuvasse, diplomaatilisi suhteid käsitlevate dokumentide jõudmisest internetti

  19. Leveraging the checkpoint-restart technique for optimizing CPU efficiency of ATLAS production applications on opportunistic platforms

    CERN Document Server

    Cameron, David; The ATLAS collaboration

    2017-01-01

    Data processing applications of the ATLAS experiment, such as event simulation and reconstruction, spend considerable amount of time in the initialization phase. This phase includes loading a large number of shared libraries, reading detector geometry and condition data from external databases, building a transient representation of the detector geometry and initializing various algorithms and services. In some cases the initialization step can take as long as 10-15 minutes. Such slow initialization, being inherently serial, has a significant negative impact on overall CPU efficiency of the production job, especially when the job is executed on opportunistic, often short-lived, resources such as commercial clouds or volunteer computing. In order to improve this situation, we can take advantage of the fact that ATLAS runs large numbers of production jobs with similar configuration parameters (e.g. jobs within the same production task). This allows us to checkpoint one job at the end of its configuration step a...

  20. Nine reasons to restart playing the harmonica%重拾口琴的9个理由

    Institute of Scientific and Technical Information of China (English)

    洱沥

    2011-01-01

    @@ 理由一:别拿口琴不当乐器 这年头,想学乐器的人越来越多,但很多人对口琴并不熟悉,甚至有人认为它是玩具.事实上,口琴的种类繁多,曲调丰富,技术含量很高,是蓝调音乐的一件重要乐器,历史上出过不少口琴大师.

  1. Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease.

    Science.gov (United States)

    Sarkar, Sovan; Maetzel, Dorothea; Korolchuk, Viktor I; Jaenisch, Rudolf

    2014-06-01

    Autophagy is essential for cellular homeostasis and its dysfunction in human diseases has been implicated in the accumulation of misfolded protein and in cellular toxicity. We have recently shown impairment in autophagic flux in the lipid storage disorder, Niemann-Pick type C1 (NPC1) disease associated with abnormal cholesterol sequestration, where maturation of autophagosomes is impaired due to defective amphisome formation caused by failure in SNARE machinery. Abrogation of autophagy also causes cholesterol accumulation, suggesting that defective autophagic flux in NPC1 disease may act as a primary causative factor not only by imparting its deleterious effects, but also by increasing cholesterol load. However, cholesterol depletion treatment with HP-β-cyclodextrin impedes autophagy, whereas pharmacologically stimulating autophagy restores its function independent of amphisome formation. Of potential therapeutic relevance is that a low dose of HP-β-cyclodextrin that does not perturb autophagy, coupled with an autophagy inducer, may rescue both the cholesterol and autophagy defects in NPC1 disease.

  2. Edward Lucas: Venemaa loodab suhete "restart´i" teha ka Balti riikidega / Edward Lucas ; intervjueerinud Argo Ideon

    Index Scriptorium Estoniae

    Lucas, Edward

    2010-01-01

    Eesti-Vene suhete arengust, Eesti sisepoliitikast, liitumisest euroga, riigieelarve kärbetest, Euroopa riikide suhtumisest Eestis toimuvasse, diplomaatilisi suhteid käsitlevate dokumentide jõudmisest internetti

  3. The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks.

    Science.gov (United States)

    Hanada, Katsuhiro; Budzowska, Magda; Davies, Sally L; van Drunen, Ellen; Onizawa, Hideo; Beverloo, H Berna; Maas, Alex; Essers, Jeroen; Hickson, Ian D; Kanaar, Roland

    2007-11-01

    Faithful duplication of the genome requires structure-specific endonucleases such as the RuvABC complex in Escherichia coli. These enzymes help to resolve problems at replication forks that have been disrupted by DNA damage in the template. Much less is known about the identities of these enzymes in mammalian cells. Mus81 is the catalytic component of a eukaryotic structure-specific endonuclease that preferentially cleaves branched DNA substrates reminiscent of replication and recombination intermediates. Here we explore the mechanisms by which Mus81 maintains chromosomal stability. We found that Mus81 is involved in the formation of double-strand DNA breaks in response to the inhibition of replication. Moreover, in the absence of chromosome processing by Mus81, recovery of stalled DNA replication forks is attenuated and chromosomal aberrations arise. We suggest that Mus81 suppresses chromosomal instability by converting potentially detrimental replication-associated DNA structures into intermediates that are more amenable to DNA repair.

  4. Methods for age estimation

    Directory of Open Access Journals (Sweden)

    D. Sümeyra Demirkıran

    2014-03-01

    Full Text Available Concept of age estimation plays an important role on both civil law and regulation of criminal behaviors. In forensic medicine, age estimation is practiced for individual requests as well for request of the court. In this study it is aimed to compile the methods of age estimation and to make recommendations for the solution of the problems encountered. In radiological method the epiphyseal lines of the bones and views of the teeth are used. In order to estimate the age by comparing bone radiographs; Greulich-Pyle Atlas (GPA, Tanner-Whitehouse Atlas (TWA and “Adli Tıpta Yaş Tayini (ATYT” books are used. Bone age is found to be 2 years older averagely than chronologic age, especially in puberty, according to the forensic age estimations described in the ATYT book. For the age estimation with teeth, Demirjian method is used. In time different methods are developed by modifying Demirjian method. However no accurate method was found. Histopathological studies are done on bone marrow cellularity and dermis cells. No correlation was found between histopathoogical findings and choronologic age. Important ethical and legal issues are brought with current age estimation methods especially in teenage period. Therefore it is required to prepare atlases of bone age compatible with our society by collecting the findings of the studies in Turkey. Another recommendation could be to pay attention to the courts of age raising trials of teenage women and give special emphasis on birth and population records

  5. STATISTICAL METHODS IN HISTORY

    Directory of Open Access Journals (Sweden)

    Orlov A. I.

    2016-01-01

    Full Text Available We have given a critical analysis of statistical models and methods for processing text information in historical records to establish the times when there were certain events, ie, to build science-based chronology. There are three main kinds of sources of knowledge of ancient history: ancient texts, the remains of material culture and traditions. The specific date of the extracted by archaeologists objects in most cases can not be found. The group of Academician A.T. Fomenko has developed and applied new statistical methods for analysis of historical texts (Chronicle, based on the intensive use of computer technology. Two major scientific results were: the majority of historical records that we know now, are duplicated (in particular, chronicles, describing the so-called "Ancient Rome" and "Middle Ages", talking about the same events; the known historical chronicles tell us about real events, separated from the present time for not more than 1000 years. It was found that chronicles describing the history of "ancient times" and "Middle Ages" and the chronicle of Chinese history and the history of various European countries do not talk about different, but about the same events. We have the attempt of a new dating of historical events and restoring the true history of human society based on new data. From the standpoint of statistical methods of historical records and images of their fragments – they are special cases of non-numeric objects of nature. Therefore, developed by the group of A.T. Fomenko computer-statistical methods are the part of non-numerical statistics. We have considered some methods of statistical analysis of chronicles applied by the group of A.T. Fomenko: correlation method of maximums; dynasties method; the method of attenuation frequency; questionnaire method codes. New chronology allows us to understand much of the battle of ideas in modern science and mass consciousness. It becomes clear the root cause of cautious

  6. The Prescribed Velocity Method

    DEFF Research Database (Denmark)

    Nielsen, Peter Vilhelm

    The- velocity level in a room ventilated by jet ventilation is strongly influenced by the supply conditions. The momentum flow in the supply jets controls the air movement in the room and, therefore, it is very important that the inlet conditions and the numerical method can generate a satisfactory...... description of this momentum flow. The Prescribed Velocity Method is a practical method for the description of an Air Terminal Device which will save grid points close to the opening and ensure the right level of the momentum flow....

  7. Methods in mummy research

    DEFF Research Database (Denmark)

    Lynnerup, Niels

    2009-01-01

    Mummies are human remains with preservation of non-bony tissue. Many mummy studies focus on the development and application of non-destructive methods for examining mummies, including radiography, CT-scanning with advanced 3-dimensional visualisations, and endoscopic techniques, as well as minima......Mummies are human remains with preservation of non-bony tissue. Many mummy studies focus on the development and application of non-destructive methods for examining mummies, including radiography, CT-scanning with advanced 3-dimensional visualisations, and endoscopic techniques, as well...... as minimally-destructive chemical, physical and biological methods for, e.g., stable isotopes, trace metals and DNA....

  8. Modern diffraction methods

    CERN Document Server

    Mittemeijer, E J

    2013-01-01

    The role of diffraction methods for the solid-state sciences has been pivotal to determining the (micro)structure of a material. Particularly, the expanding activities in materials science have led to the development of new methods for analysis by diffraction. This book offers an authoritative overview of the new developments in the field of analysis of matter by (in particular X-ray, electron and neutron) diffraction. It is composed of chapters written by leading experts on 'modern diffraction methods'. The focus in the various chapters of this book is on the current forefront of research on

  9. Methods in Bioengineering

    CERN Document Server

    Jayaraman, Arul

    2009-01-01

    This volume provides a detailed look at the two main aspects of systems biology: the design of sophisticated experimental methods and the development of complex models to analyze the data. Focusing on methods that are being used to solve current problems in biomedical science and engineering, this comprehensive, richly illustrated resource shows you how to design of state-of-the art methods for analyzing biological systems, implement experimental approaches for investigating cellular behavior in health and disease, use algorithms and modeling techniques for quantitatively describing biomedical

  10. Montessori Method and ICTs

    Directory of Open Access Journals (Sweden)

    Athanasios Drigas

    2016-03-01

    Full Text Available This article bridges the gap between the Montessori Method and Information and Communication Technologies (ICTs in contemporary education. It reviews recent research works which recall the Montessori philosophy, principles and didactical tools applying to today’s computers and supporting technologies in children’s learning process. This article reviews how important the stimulation of human senses in the learning process is, as well as the development of Montessori materials using the body and the hand in particular, all according to the Montessori Method along with recent researches over ICTs. Montessori Method within information society age acquires new perspectives, new functionality and new efficacy.

  11. Numerical methods using Matlab

    CERN Document Server

    Lindfield, George

    2012-01-01

    Numerical Methods using MATLAB, 3e, is an extensive reference offering hundreds of useful and important numerical algorithms that can be implemented into MATLAB for a graphical interpretation to help researchers analyze a particular outcome. Many worked examples are given together with exercises and solutions to illustrate how numerical methods can be used to study problems that have applications in the biosciences, chaos, optimization, engineering and science across the board. Numerical Methods using MATLAB, 3e, is an extensive reference offering hundreds of use

  12. Methods of flash sintering

    Energy Technology Data Exchange (ETDEWEB)

    Raj, Rishi; Cologna, Marco; Francis, John S.

    2016-05-10

    This disclosure provides methods of flash sintering and compositions created by these methods. Methods for sintering multilayered bodies are provided in which a sintered body is produced in less than one minute. In one aspect, each layer is of a different composition, and may be constituted wholly from a ceramic or from a combination of ceramic and metallic particles. When the body includes a layer of an anode composition, a layer of an electrolyte composition and a layer of a cathode composition, the sintered body can be used to produce a solid oxide fuel cell.

  13. Structural Reliability Methods

    DEFF Research Database (Denmark)

    Ditlevsen, Ove Dalager; Madsen, H. O.

    of structural reliability, including the theoretical basis for these methods. Partial safety factor codes under current practice are briefly introduced and discussed. A probabilistic code format for obtaining a formal reliability evaluation system that catches the most essential features of the nature......The structural reliability methods quantitatively treat the uncertainty of predicting the behaviour and properties of a structure given the uncertain properties of its geometry, materials, and the actions it is supposed to withstand. This book addresses the probabilistic methods for evaluation...

  14. Generalized subspace correction methods

    Energy Technology Data Exchange (ETDEWEB)

    Kolm, P. [Royal Institute of Technology, Stockholm (Sweden); Arbenz, P.; Gander, W. [Eidgenoessiche Technische Hochschule, Zuerich (Switzerland)

    1996-12-31

    A fundamental problem in scientific computing is the solution of large sparse systems of linear equations. Often these systems arise from the discretization of differential equations by finite difference, finite volume or finite element methods. Iterative methods exploiting these sparse structures have proven to be very effective on conventional computers for a wide area of applications. Due to the rapid development and increasing demand for the large computing powers of parallel computers, it has become important to design iterative methods specialized for these new architectures.

  15. Ensemble Data Mining Methods

    Science.gov (United States)

    Oza, Nikunj C.

    2004-01-01

    Ensemble Data Mining Methods, also known as Committee Methods or Model Combiners, are machine learning methods that leverage the power of multiple models to achieve better prediction accuracy than any of the individual models could on their own. The basic goal when designing an ensemble is the same as when establishing a committee of people: each member of the committee should be as competent as possible, but the members should be complementary to one another. If the members are not complementary, Le., if they always agree, then the committee is unnecessary---any one member is sufficient. If the members are complementary, then when one or a few members make an error, the probability is high that the remaining members can correct this error. Research in ensemble methods has largely revolved around designing ensembles consisting of competent yet complementary models.

  16. Adaptive Algebraic Multigrid Methods

    Energy Technology Data Exchange (ETDEWEB)

    Brezina, M; Falgout, R; MacLachlan, S; Manteuffel, T; McCormick, S; Ruge, J

    2004-04-09

    Our ability to simulate physical processes numerically is constrained by our ability to solve the resulting linear systems, prompting substantial research into the development of multiscale iterative methods capable of solving these linear systems with an optimal amount of effort. Overcoming the limitations of geometric multigrid methods to simple geometries and differential equations, algebraic multigrid methods construct the multigrid hierarchy based only on the given matrix. While this allows for efficient black-box solution of the linear systems associated with discretizations of many elliptic differential equations, it also results in a lack of robustness due to assumptions made on the near-null spaces of these matrices. This paper introduces an extension to algebraic multigrid methods that removes the need to make such assumptions by utilizing an adaptive process. The principles which guide the adaptivity are highlighted, as well as their application to algebraic multigrid solution of certain symmetric positive-definite linear systems.

  17. Methods for cellobiosan utilization

    Energy Technology Data Exchange (ETDEWEB)

    Linger, Jeffrey; Beckham, Gregg T.

    2017-07-11

    Disclosed herein are enzymes useful for the degradation of cellobiosan in materials such a pyrolysis oils. Methods of degrading cellobiosan using enzymes or organisms expressing the same are also disclosed.

  18. Compressive Spectral Renormalization Method

    CERN Document Server

    Bayindir, Cihan

    2016-01-01

    In this paper a novel numerical scheme for finding the sparse self-localized states of a nonlinear system of equations with missing spectral data is introduced. As in the Petviashivili's and the spectral renormalization method, the governing equation is transformed into Fourier domain, but the iterations are performed for far fewer number of spectral components (M) than classical versions of the these methods with higher number of spectral components (N). After the converge criteria is achieved for M components, N component signal is reconstructed from M components by using the l1 minimization technique of the compressive sampling. This method can be named as compressive spectral renormalization (CSRM) method. The main advantage of the CSRM is that, it is capable of finding the sparse self-localized states of the evolution equation(s) with many spectral data missing.

  19. Iii. Sleep assessment methods.

    Science.gov (United States)

    Sadeh, Avi

    2015-03-01

    Sleep is a complex phenomenon that could be understood and assessed at many levels. Sleep could be described at the behavioral level (relative lack of movements and awareness and responsiveness) and at the brain level (based on EEG activity). Sleep could be characterized by its duration, by its distribution during the 24-hr day period, and by its quality (e.g., consolidated versus fragmented). Different methods have been developed to assess various aspects of sleep. This chapter covers the most established and common methods used to assess sleep in infants and children. These methods include polysomnography, videosomnography, actigraphy, direct observations, sleep diaries, and questionnaires. The advantages and disadvantages of each method are highlighted.

  20. Stochastic optimization methods

    CERN Document Server

    Marti, Kurt

    2005-01-01

    Optimization problems arising in practice involve random parameters. For the computation of robust optimal solutions, i.e., optimal solutions being insensitive with respect to random parameter variations, deterministic substitute problems are needed. Based on the distribution of the random data, and using decision theoretical concepts, optimization problems under stochastic uncertainty are converted into deterministic substitute problems. Due to the occurring probabilities and expectations, approximative solution techniques must be applied. Deterministic and stochastic approximation methods and their analytical properties are provided: Taylor expansion, regression and response surface methods, probability inequalities, First Order Reliability Methods, convex approximation/deterministic descent directions/efficient points, stochastic approximation methods, differentiation of probability and mean value functions. Convergence results of the resulting iterative solution procedures are given.

  1. Methods for euclidean geometry

    CERN Document Server

    Byer, Owen; Smeltzer, Deirdre L

    2010-01-01

    Euclidean plane geometry is one of the oldest and most beautiful topics in mathematics. Instead of carefully building geometries from axiom sets, this book uses a wealth of methods to solve problems in Euclidean geometry. Many of these methods arose where existing techniques proved inadequate. In several cases, the new ideas used in solving specific problems later developed into independent areas of mathematics. This book is primarily a geometry textbook, but studying geometry in this way will also develop students' appreciation of the subject and of mathematics as a whole. For instance, despite the fact that the analytic method has been part of mathematics for four centuries, it is rarely a tool a student considers using when faced with a geometry problem. Methods for Euclidean Geometry explores the application of a broad range of mathematical topics to the solution of Euclidean problems.

  2. Methods in Modern Biophysics

    CERN Document Server

    Nölting, Bengt

    2010-01-01

    Incorporating recent dramatic advances, this textbook presents a fresh and timely introduction to modern biophysical methods. An array of new, faster and higher-power biophysical methods now enables scientists to examine the mysteries of life at a molecular level. This innovative text surveys and explains the ten key biophysical methods, including those related to biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobility spectrometry, mass spectrometry, proteomics, and protein folding and structure. Incorporating much information previously unavailable in tutorial form, Nölting employs worked examples and about 270 illustrations to fully detail the techniques and their underlying mechanisms. Methods in Modern Biophysics is written for advanced undergraduate and graduate students, postdocs, researchers, lecturers, and professors in biophysics, biochemistry and related fields. Special features in the 3rd edition: Introduces rapid partial protein ladder sequencing - an important...

  3. Concrete compositions and methods

    Science.gov (United States)

    Chen, Irvin; Lee, Patricia Tung; Patterson, Joshua

    2015-06-23

    Provided herein are compositions, methods, and systems for cementitious compositions containing calcium carbonate compositions and aggregate. The compositions find use in a variety of applications, including use in a variety of building materials and building applications.

  4. Monte Carlo methods

    OpenAIRE

    Bardenet, R.

    2012-01-01

    ISBN:978-2-7598-1032-1; International audience; Bayesian inference often requires integrating some function with respect to a posterior distribution. Monte Carlo methods are sampling algorithms that allow to compute these integrals numerically when they are not analytically tractable. We review here the basic principles and the most common Monte Carlo algorithms, among which rejection sampling, importance sampling and Monte Carlo Markov chain (MCMC) methods. We give intuition on the theoretic...

  5. Business forecasting methods

    OpenAIRE

    Skribans, V.

    2002-01-01

    The paper comprises three parts: description of the forecasting conception, classification of forecasting methods, and the general forecasting model. The first part deals with the definition of business forecasting, the second classifies and deals in more detail with the most frequently practiced forecasting methods and comes up with recommendations how to apply them in specific situations. The third part present the analysis of newly established forecasting model.

  6. Bidirectional beam propagation method

    Science.gov (United States)

    Kaczmarski, P.; Lagasse, P. E.

    1988-05-01

    A bidirectional extension of the beam propagation method (BPM) to optical waveguides with a longitudinal discontinuity is presented. The algorithm is verified by computing a reflection of the TE(0) mode from a semiconductor laser facet. The bidirectional BPM is applicable to other configurations such as totally reflecting waveguide mirrors, an abruption transition in a waveguide, or a waveguide with many discontinuities generating multiple reflections. The method can also be adapted to TM polarization.

  7. Method of treating depression

    Energy Technology Data Exchange (ETDEWEB)

    Henn, Fritz

    2013-04-09

    Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive K.sup.+ channel openers and .beta.-lactam antibiotics are used to enhance glutamate transport and to treat depression-related mood disorders and depressive symptoms.

  8. Method of treating depression

    Science.gov (United States)

    Henn, Fritz [East Patchogue, NY

    2012-01-24

    Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive K.sup.+ channel openers and .beta.-lactam antibiotics are used to enhance glutamate transport and to treat depression-related mood disorders and depressive symptoms.

  9. On Danish Legal Method

    DEFF Research Database (Denmark)

    Schaumburg-Müller, Sten

    2014-01-01

    On the basis on 1) the Danish legal writer A.S.Ørsted (1778-1860) and 2) an enquete among present day Danish legal scholars, the contribution deals with special traits in Danish legal method......On the basis on 1) the Danish legal writer A.S.Ørsted (1778-1860) and 2) an enquete among present day Danish legal scholars, the contribution deals with special traits in Danish legal method...

  10. Methods for polymer synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Scott D.; Simoneau, Christopher A.; Keefe, William D.; Conuel, Jeff R.

    2016-12-06

    The present invention provides methods for reducing induction periods in epoxide-CO.sub.2 copolymerizations. In certain embodiments, the methods include the step of contacting an epoxide with CO.sub.2 in the presence of two catalysts: an epoxide hydrolysis catalyst and an epoxide CO.sub.2 copolymerization catalyst. In another aspect, the invention provides catalyst compositions comprising a mixture of an epoxide hydrolysis catalyst and an epoxide CO.sub.2 copolymerization catalyst.

  11. Modern Methods in Marketing

    OpenAIRE

    Jandová, Pavlína

    2007-01-01

    Traditional marketing methods are losing their effectiveness and credibility. It has been worse and worse to communicate with customers, and marketers are therefore looking for new techniques and way how to appeal buyers. They turn to the use of modern marketing methods, which typical features are possibility of accurate targeting and low costs, and, also, the fact that they are still not considered being a classic promotion. In the theoretical part of the diploma thesis the alternative marke...

  12. Painful Bile Extraction Methods

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    It was only in the past 20 years that countries in Asia began to search for an alternative to protect moon bears from being killed for their bile and other body parts. In the early 1980s, a new method of extracting bile from living bears was developed in North Korea. In 1983, Chinese scientists imported this technique from North Korea. According to the Animals Asia Foundation, the most original method of bile extraction is to embed a latex catheter, a narrow rubber

  13. [Unproven methods in oncology].

    Science.gov (United States)

    Jallut, O; Guex, P; Barrelet, L

    1984-09-08

    As in some other chronic diseases (rheumatism, multiple sclerosis, etc.), unproven methods of diagnosis and treatment have long been current in cancer. Since 1960 the American Cancer Society has published an abundant literature on these "unproven methods", which serves as a basis for a historical review: some substances (Krebiozen, Laetrile) have enjoyed tremendous if shortlived success. The present trend is back to nature and "mild medicine". The proponents of this so-called natural medicine are often disciples of a pseudoscientific religion using irrational arguments. Direct attacks on these erroneous theories and their public refutation fail to convince the adepts, who trust in these methods and are not amenable to a scientific approach. Study of their psychological motivations reveals that in fact they seek something more reassuring than plain medical explanation which is aware of its limits. They feel reassured by theories which often bear some resemblance to the old popular medicine. To protect patients against these dangerous methods and all the disillusionment they entail, the Swiss Society of Oncology and the Swiss Cancer League have decided to gather information and draw up a descriptive list of the commonest unproven methods in Switzerland (our File No. 2, "Total anti-cancer cure", is given as an example). The files are published in French, German and English and are available to physicians, nursing teams, and also patients who wish to have more objective information on these methods.

  14. Multicriteria identification sets method

    Science.gov (United States)

    Kamenev, G. K.

    2016-11-01

    A multicriteria identification and prediction method for mathematical models of simulation type in the case of several identification criteria (error functions) is proposed. The necessity of the multicriteria formulation arises, for example, when one needs to take into account errors of completely different origins (not reducible to a single characteristic) or when there is no information on the class of noise in the data to be analyzed. An identification sets method is described based on the approximation and visualization of the multidimensional graph of the identification error function and sets of suboptimal parameters. This method allows for additional advantages of the multicriteria approach, namely, the construction and visual analysis of the frontier and the effective identification set (frontier and the Pareto set for identification criteria), various representations of the sets of Pareto effective and subeffective parameter combinations, and the corresponding predictive trajectory tubes. The approximation is based on the deep holes method, which yields metric ɛ-coverings with nearly optimal properties, and on multiphase approximation methods for the Edgeworth-Pareto hull. The visualization relies on the approach of interactive decision maps. With the use of the multicriteria method, multiple-choice solutions of identification and prediction problems can be produced and justified by analyzing the stability of the optimal solution not only with respect to the parameters (robustness with respect to data) but also with respect to the chosen set of identification criteria (robustness with respect to the given collection of functionals).

  15. [Barrier methods of contraception].

    Science.gov (United States)

    Goldsmith, A; Edelman, D A

    1982-01-01

    Vaginal methods of contraception were the earliest types used and some references to them date back to antiquity. Most of the vaginal contraceptive agents identified by the ancient Greeks, Indians, Japanese, and Chinese have been found in modern laboratory tests to have spermicidal properties, but it is doubtful that the methods were fully reliable or were used by many people. During the 19th century the condom, vaginal spermicides, and diaphragm became available. The development of nonoxynol-9 and other nonirritating but effective spermicidal agents improved vaginal contraceptives greatly by the 1950s, but starting in the 1960s newer methods began to replace the vaginal methods. Interest in barrier methods has been reawakened somewhat by concern about the health effects of hormonal methods. At present all barrier methods leave something to be desired. Failure rates of 3-30% for barrier methods in general have been estimated, but the higher rates are believed due to incorrect or inconsistent use. Theoretical failure rates of condoms and diaphragms have been estimated at 3/100 women-years, but in actual use failure rates may reach 15 for condoms and 13 for diaphragms used with spermicides. Use-effectiveness rates are greatly influenced by motivation. For a variety of reasons, the acceptability of barrier methods is low, especially in developing countries. New developments in spermicidal agents include sperm inhibitors, which impede the fertilizing capacity of sperm rather than attempting a spermicidal effect; a number of such agents have been studied and have proven more effective in animal tests than conventional spermicides. Neosampoon, a new spermicidal foam, has attracted an increasing number of users, especially in developing countries. A new condom, made of thin polymers and containing a standard dose of nonoxynol-9, has been designed to dissolve in the vaginal fluid. Further studies are needed of its acceptability, efficacy, and side effects before it becomes

  16. The ICARE Method

    Science.gov (United States)

    Henke, Luke

    2010-01-01

    The ICARE method is a flexible, widely applicable method for systems engineers to solve problems and resolve issues in a complete and comprehensive manner. The method can be tailored by diverse users for direct application to their function (e.g. system integrators, design engineers, technical discipline leads, analysts, etc.). The clever acronym, ICARE, instills the attitude of accountability, safety, technical rigor and engagement in the problem resolution: Identify, Communicate, Assess, Report, Execute (ICARE). This method was developed through observation of Space Shuttle Propulsion Systems Engineering and Integration (PSE&I) office personnel approach in an attempt to succinctly describe the actions of an effective systems engineer. Additionally it evolved from an effort to make a broadly-defined checklist for a PSE&I worker to perform their responsibilities in an iterative and recursive manner. The National Aeronautics and Space Administration (NASA) Systems Engineering Handbook states, engineering of NASA systems requires a systematic and disciplined set of processes that are applied recursively and iteratively for the design, development, operation, maintenance, and closeout of systems throughout the life cycle of the programs and projects. ICARE is a method that can be applied within the boundaries and requirements of NASA s systems engineering set of processes to provide an elevated sense of duty and responsibility to crew and vehicle safety. The importance of a disciplined set of processes and a safety-conscious mindset increases with the complexity of the system. Moreover, the larger the system and the larger the workforce, the more important it is to encourage the usage of the ICARE method as widely as possible. According to the NASA Systems Engineering Handbook, elements of a system can include people, hardware, software, facilities, policies and documents; all things required to produce system-level results, qualities, properties, characteristics

  17. VALUATION METHODS- LITERATURE REVIEW

    Directory of Open Access Journals (Sweden)

    Dorisz Talas

    2015-07-01

    Full Text Available This paper is a theoretical overview of the often used valuation methods with the help of which the value of a firm or its equity is calculated. Many experts (including Aswath Damodaran, Guochang Zhang and CA Hozefa Natalwala classify the methods. The basic models are based on discounted cash flows. The main method uses the free cash flow for valuation, but there are some newer methods that reveal and correct the weaknesses of the traditional models. The valuation of flexibility of management can be conducted mainly with real options. This paper briefly describes the essence of the Dividend Discount Model, the Free Cash Flow Model, the benefit from using real options and the Residual Income Model. There are a few words about the Adjusted Present Value approach as well. Different models uses different premises, and an overall truth is that if the required premises are real and correct, the value will be appropriately accurate. Another important condition is that experts, analysts should choose between the models on the basis of the purpose of valuation. Thus there are no good or bad methods, only methods that fit different goals and aims. The main task is to define exactly the purpose, then to find the most appropriate valuation technique. All the methods originates from the premise that the value of an asset is the present value of its future cash flows. According to the different points of view of different techniques the resulted values can be also differed from each other. Valuation models and techniques should be adapted to the rapidly changing world, but the basic statements remain the same. On the other hand there is a need for more accurate models in order to help investors get as many information as they could. Today information is one of the most important resources and financial models should keep up with this trend.

  18. Molecular methods for biofilms

    KAUST Repository

    Ferrera, Isabel

    2014-08-30

    This chapter deals with both classical and modern molecular methods that can be useful for the identification of microorganisms, elucidation and comparison of microbial communities, and investigation of their diversity and functions. The most important and critical steps necessary for all molecular methods is DNA isolation from microbial communities and environmental samples; these are discussed in the first part. The second part provides an overview over DNA polymerase chain reaction (PCR) amplification and DNA sequencing methods. Protocols and analysis software as well as potential pitfalls associated with application of these methods are discussed. Community fingerprinting analyses that can be used to compare multiple microbial communities are discussed in the third part. This part focuses on Denaturing Gradient Gel Electrophoresis (DGGE), Terminal Restriction Fragment Length Polymorphism (T-RFLP) and Automated rRNA Intergenic Spacer Analysis (ARISA) methods. In addition, classical and next-generation metagenomics methods are presented. These are limited to bacterial artificial chromosome and Fosmid libraries and Sanger and next-generation 454 sequencing, as these methods are currently the most frequently used in research. Isolation of nucleic acids: This chapter discusses, the most important and critical steps necessary for all molecular methods is DNA isolation from microbial communities and environmental samples. Nucleic acid isolation methods generally include three steps: cell lysis, removal of unwanted substances, and a final step of DNA purification and recovery. The first critical step is the cell lysis, which can be achieved by enzymatic or mechanical procedures. Removal of proteins, polysaccharides and other unwanted substances is likewise important to avoid their interference in subsequent analyses. Phenol-chloroform-isoamyl alcohol is commonly used to recover DNA, since it separates nucleic acids into an aqueous phase and precipitates proteins and

  19. New oligosaccharyltransferase assay method.

    Science.gov (United States)

    Kohda, Daisuke; Yamada, Masaki; Igura, Mayumi; Kamishikiryo, Jun; Maenaka, Katsumi

    2007-11-01

    We developed a new in vitro assay for oligosaccharyltransferase (OST), which catalyzes the transfer of preassembled oligosaccharides on lipid carriers onto asparagine residues in polypeptide chains. The asparagine residues reside in the sequon, Asn-X-Thr/Ser, where X can be any amino acid residue except Pro. We demonstrate the potency of our assay using the OST from yeast. In our method, polyacrylamide gel electrophoresis is used to separate the glycopeptide products from the peptide substrates. The substrate peptide is fluorescently labeled and the formation of glycopeptides is analyzed by fluorescence gel imaging. Two in vitro OST assay methods are now widely used, but both the methods depend on previous knowledge of the oligosaccharide moiety: One method uses lectin binding as the separation mechanism and the other method uses biosynthetically or chemoenzymatically synthesized lipid-linked oligosaccharides as donors. N-linked protein glycosylation is found in all three domains of life, but little is known about the N-glycosylation in Archaea. Thus, our new assay, which does not require a priori knowledge of the oligosaccharides, will be useful in such cases. Indeed, we have detected the OST activity in the membrane fraction from a hyperthermophilic archaeon, Pyrococcus furiosus.

  20. Methods for Neutron Spectrometry

    Science.gov (United States)

    Brockhouse, Bertram N.

    1961-01-09

    The appropriate theories and the general philosophy of methods of measurement and treatment of data neutron spectrometry are discussed. Methods of analysis of results for liquids using the Van Hove formulation, and for crystals using the Born-von Karman theory, are reviewed. The most useful of the available methods of measurement are considered to be the crystal spectrometer methods and the pulsed monoenergetic beam/time-of-flight method. Pulsed-beam spectrometers have the advantage of higher counting rates than crystal spectrometers, especially in view of the fact that simultaneous measurements in several counters at different angles of scattering are possible in pulsed-beam spectrometers. The crystal spectrometer permits several valuable new types of specialized experiments to be performed, especially energy distribution measurements at constant momentum transfer. The Chalk River triple-axis crystal-spectrometer is discussed, with reference to its use in making the specialized experiments. The Chalk River rotating crystal (pulsed-beam) spectrometer is described, and a comparison of this type instrument with other pulsed-beam spectrometers is made. A partial outline of the theory of operation of rotating-crystal spectrometers is presented. The use of quartz-crystal filters for fast neutron elimination and for order elimination is discussed. (auth)

  1. The lod score method.

    Science.gov (United States)

    Rice, J P; Saccone, N L; Corbett, J

    2001-01-01

    The lod score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage. In addition, the method is sequential, so that pedigrees or lod curves may be combined from published reports to pool data for analysis. This approach has been remarkably successful for 50 years in identifying disease genes for Mendelian disorders. After discussing these issues, we consider the situation for complex disorders, where the maximum lod score (MLS) statistic shares some of the advantages of the traditional lod score approach but is limited by unknown power and the lack of sharing of the primary data needed to optimally combine analytic results. We may still learn from the lod score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes.

  2. Fashion, Mediations & Method Assemblages

    DEFF Research Database (Denmark)

    Sommerlund, Julie; Jespersen, Astrid Pernille

    , respectively. The paper thus takes on aesthetics and the social in a manner closely related to a core argument of STS - namely that the scientific fact, and the social processes of constructing, distributing, and using that fact, are co-constructed (Callon, 1986; Latour, 1993). The paper thus contributes......, it is an important ambition of this paper to go into a methodological discussion of how "that which effectively happens" can be approached. To this end, the paper will combine Hennion's term of the "mediator" with John Laws methodological term of "method assemblages". Method assemblages is a suggested as a way...... of handling multiple, fluid realities with multiple, fluid methods. Empirically, the paper works with mediation in fashion - that is efforts the active shaping of relations between producer and consumer through communication, marketing and PR. Fashion mediation is by no means simple, but organise complex...

  3. Cytoskeleton - Methods and Protocols

    Directory of Open Access Journals (Sweden)

    CarloAlberto Redi

    2010-03-01

    Full Text Available Cytoskeleton - Methods and ProtocolsSecond edition, 2010; Ray H. Gavin (Ed; Springer Protocols methods in molecular biology, vol. 586 Humana press, Totowa, New Jersey (USA; Pages: 390; €95.44; ISBN: 978-1-60761-375-6Ray H. Gavin, from the Brooklyn College of The City University of New York, Brooklyn, NY, USA, wrote a few line as preface of this book. This is quite understandable: there is not a great need of words when there are facts that sustain and favour the dissemination of a cultural product. This is the case of the second edition of Cytoskeleton - Methods and Protocols, which appears just ten years after the first edition...

  4. Geostatistical Methods in R

    Directory of Open Access Journals (Sweden)

    Adéla Volfová

    2012-10-01

    Full Text Available Geostatistics is a scientific field which provides methods for processing spatial data.  In our project, geostatistics is used as a tool for describing spatial continuity and making predictions of some natural phenomena. An open source statistical project called R is used for all calculations. Listeners will be provided with a brief introduction to R and its geostatistical packages and basic principles of kriging and cokriging methods. Heavy mathematical background is omitted due to its complexity. In the second part of the presentation, several examples are shown of how to make a prediction in the whole area of interest where observations were made in just a few points. Results of these methods are compared.

  5. Robust iterative methods

    Energy Technology Data Exchange (ETDEWEB)

    Saadd, Y.

    1994-12-31

    In spite of the tremendous progress achieved in recent years in the general area of iterative solution techniques, there are still a few obstacles to the acceptance of iterative methods in a number of applications. These applications give rise to very indefinite or highly ill-conditioned non Hermitian matrices. Trying to solve these systems with the simple-minded standard preconditioned Krylov subspace methods can be a frustrating experience. With the mathematical and physical models becoming more sophisticated, the typical linear systems which we encounter today are far more difficult to solve than those of just a few years ago. This trend is likely to accentuate. This workshop will discuss (1) these applications and the types of problems that they give rise to; and (2) recent progress in solving these problems with iterative methods. The workshop will end with a hopefully stimulating panel discussion with the speakers.

  6. Energy methods in dynamics

    CERN Document Server

    Le, Khanh Chau

    2012-01-01

    The above examples should make clear the necessity of understanding the mechanism of vibrations and waves in order to control them in an optimal way. However vibrations and waves are governed by differential equations which require, as a rule, rather complicated mathematical methods for their analysis. The aim of this textbook is to help students acquire both a good grasp of the first principles from which the governing equations can be derived, and the adequate mathematical methods for their solving. Its distinctive features, as seen from the title, lie in the systematic and intensive use of Hamilton's variational principle and its generalizations for deriving the governing equations of conservative and dissipative mechanical systems, and also in providing the direct variational-asymptotic analysis, whenever available, of the energy and dissipation for the solution of these equations. It will be demonstrated that many well-known methods in dynamics like those of Lindstedt-Poincare, Bogoliubov-Mitropolsky, Ko...

  7. Energy methods in dynamics

    CERN Document Server

    Le, Khanh Chau

    2014-01-01

    Energy Methods in Dynamics is a textbook based on the lectures given by the first author at Ruhr University Bochum, Germany. Its aim is to help students acquire both a good grasp of the first principles from which the governing equations can be derived, and the adequate mathematical methods for their solving. Its distinctive features, as seen from the title, lie in the systematic and intensive use of Hamilton's variational principle and its generalizations for deriving the governing equations of conservative and dissipative mechanical systems, and also in providing the direct variational-asymptotic analysis, whenever available, of the energy and dissipation for the solution of these equations. It demonstrates that many well-known methods in dynamics like those of Lindstedt-Poincare, Bogoliubov-Mitropolsky, Kolmogorov-Arnold-Moser (KAM), Wentzel–Kramers–Brillouin (WKB),  and Whitham are derivable from this variational-asymptotic analysis.   This second edition includes the solutions to all exercises as w...

  8. Sampling system and method

    Energy Technology Data Exchange (ETDEWEB)

    Decker, David L.; Lyles, Brad F.; Purcell, Richard G.; Hershey, Ronald Lee

    2017-03-07

    In one embodiment, the present disclosure provides an apparatus and method for supporting a tubing bundle during installation or removal. The apparatus includes a clamp for securing the tubing bundle to an external wireline. In various examples, the clamp is external to the tubing bundle or integral with the tubing bundle. According to one method, a tubing bundle and wireline are deployed together and the tubing bundle periodically secured to the wireline using a clamp. In another embodiment, the present disclosure provides an apparatus and method for coupling conduit segments together. A first pump obtains a sample and transmits it through a first conduit to a reservoir accessible by a second pump. The second pump further conducts the sample from the reservoir through a second conduit. In a specific example, one or more clamps are used to connect the first and/or second conduits to an external wireline.

  9. Grid generation methods

    CERN Document Server

    Liseikin, Vladimir D

    2017-01-01

    This new edition provides a description of current developments relating to grid methods, grid codes, and their applications to actual problems. Grid generation methods are indispensable for the numerical solution of differential equations. Adaptive grid-mapping techniques, in particular, are the main focus and represent a promising tool to deal with systems with singularities. This 3rd edition includes three new chapters on numerical implementations (10), control of grid properties (11), and applications to mechanical, fluid, and plasma related problems (13). Also the other chapters have been updated including new topics, such as curvatures of discrete surfaces (3). Concise descriptions of hybrid mesh generation, drag and sweeping methods, parallel algorithms for mesh generation have been included too. This new edition addresses a broad range of readers: students, researchers, and practitioners in applied mathematics, mechanics, engineering, physics and other areas of applications.

  10. Method of treating wells

    Energy Technology Data Exchange (ETDEWEB)

    Knox, J.A.; Lasater, R.M.

    1966-11-22

    Chemical compositions and methods are provided for treating underground formations to render their surfaces water-repellent or preferentially oil-wettable. Previous methods have provided only temporary water-repellency because they do not actually act chemically with the reservoir rock. This improvement is obtained by using a treating agent which does not form a precipitate upon hydrolysis with water, such as a liquid organo-halogen- silane or its ester. A water-soluble anhydrous solvent which is nonreactive with the silane is used as a carrier. This method may be used for treating non-oil-bearing aquifers for increasing the flow rate of water, such as in water supply wells, or in water input rate, such as in water disposal wells. (10 claims)

  11. Methods for RNA Analysis

    DEFF Research Database (Denmark)

    Olivarius, Signe

    of the transcriptome, 5’ end capture of RNA is combined with next-generation sequencing for high-throughput quantitative assessment of transcription start sites by two different methods. The methods presented here allow for functional investigation of coding as well as noncoding RNA and contribute to future......While increasing evidence appoints diverse types of RNA as key players in the regulatory networks underlying cellular differentiation and metabolism, the potential functions of thousands of conserved RNA structures encoded in mammalian genomes remain to be determined. Since the functions of most...... RNAs rely on interactions with proteins, the establishment of protein-binding profiles is essential for the characterization of RNAs. Aiming to facilitate RNA analysis, this thesis introduces proteomics- as well as transcriptomics-based methods for the functional characterization of RNA. First, RNA...

  12. Model Correction Factor Method

    DEFF Research Database (Denmark)

    Christensen, Claus; Randrup-Thomsen, Søren; Morsing Johannesen, Johannes

    1997-01-01

    The model correction factor method is proposed as an alternative to traditional polynomial based response surface techniques in structural reliability considering a computationally time consuming limit state procedure as a 'black box'. The class of polynomial functions is replaced by a limit...... statebased on an idealized mechanical model to be adapted to the original limit state by the model correction factor. Reliable approximations are obtained by iterative use of gradient information on the original limit state function analogously to previous response surface approaches. However, the strength...... of the model correction factor method, is that in simpler form not using gradient information on the original limit state function or only using this information once, a drastic reduction of the number of limit state evaluation is obtained together with good approximations on the reliability. Methods...

  13. Splines and variational methods

    CERN Document Server

    Prenter, P M

    2008-01-01

    One of the clearest available introductions to variational methods, this text requires only a minimal background in calculus and linear algebra. Its self-contained treatment explains the application of theoretic notions to the kinds of physical problems that engineers regularly encounter. The text's first half concerns approximation theoretic notions, exploring the theory and computation of one- and two-dimensional polynomial and other spline functions. Later chapters examine variational methods in the solution of operator equations, focusing on boundary value problems in one and two dimension

  14. Nonparametric statistical methods

    CERN Document Server

    Hollander, Myles; Chicken, Eric

    2013-01-01

    Praise for the Second Edition"This book should be an essential part of the personal library of every practicing statistician."-Technometrics  Thoroughly revised and updated, the new edition of Nonparametric Statistical Methods includes additional modern topics and procedures, more practical data sets, and new problems from real-life situations. The book continues to emphasize the importance of nonparametric methods as a significant branch of modern statistics and equips readers with the conceptual and technical skills necessary to select and apply the appropriate procedures for any given sit

  15. METHOD OF ROLLING URANIUM

    Science.gov (United States)

    Smith, C.S.

    1959-08-01

    A method is described for rolling uranium metal at relatively low temperatures and under non-oxidizing conditions. The method involves the steps of heating the uranium to 200 deg C in an oil bath, withdrawing the uranium and permitting the oil to drain so that only a thin protective coating remains and rolling the oil coated uranium at a temperature of 200 deg C to give about a 15% reduction in thickness at each pass. The operation may be repeated to accomplish about a 90% reduction without edge cracking, checking or any appreciable increase in brittleness.

  16. Electrorheological fluids and methods

    Energy Technology Data Exchange (ETDEWEB)

    Green, Peter F.; McIntyre, Ernest C.

    2015-06-02

    Electrorheological fluids and methods include changes in liquid-like materials that can flow like milk and subsequently form solid-like structures under applied electric fields; e.g., about 1 kV/mm. Such fluids can be used in various ways as smart suspensions, including uses in automotive, defense, and civil engineering applications. Electrorheological fluids and methods include one or more polar molecule substituted polyhedral silsesquioxanes (e.g., sulfonated polyhedral silsesquioxanes) and one or more oils (e.g., silicone oil), where the fluid can be subjected to an electric field.

  17. Tautomerism methods and theories

    CERN Document Server

    Antonov, Liudmil

    2013-01-01

    Covering the gap between basic textbooks and over-specialized scientific publications, this is the first reference available to describe this interdisciplinary topic for PhD students and scientists starting in the field. The result is an introductory description providing suitable practical examples of the basic methods used to study tautomeric processes, as well as the theories describing the tautomerism and proton transfer phenomena. It also includes different spectroscopic methods for examining tautomerism, such as UV-VIs, time-resolved fluorescence spectroscopy, and NMR spectrosc

  18. Unorthodox theoretical methods

    Energy Technology Data Exchange (ETDEWEB)

    Nedd, Sean [Iowa State Univ., Ames, IA (United States)

    2012-01-01

    The use of the ReaxFF force field to correlate with NMR mobilities of amine catalytic substituents on a mesoporous silica nanosphere surface is considered. The interfacing of the ReaxFF force field within the Surface Integrated Molecular Orbital/Molecular Mechanics (SIMOMM) method, in order to replicate earlier SIMOMM published data and to compare with the ReaxFF data, is discussed. The development of a new correlation consistent Composite Approach (ccCA) is presented, which incorporates the completely renormalized coupled cluster method with singles, doubles and non-iterative triples corrections towards the determination of heats of formations and reaction pathways which contain biradical species.

  19. Exploring Monte Carlo methods

    CERN Document Server

    Dunn, William L

    2012-01-01

    Exploring Monte Carlo Methods is a basic text that describes the numerical methods that have come to be known as "Monte Carlo." The book treats the subject generically through the first eight chapters and, thus, should be of use to anyone who wants to learn to use Monte Carlo. The next two chapters focus on applications in nuclear engineering, which are illustrative of uses in other fields. Five appendices are included, which provide useful information on probability distributions, general-purpose Monte Carlo codes for radiation transport, and other matters. The famous "Buffon's needle proble

  20. Method through motion

    DEFF Research Database (Denmark)

    Steijn, Arthur

    2016-01-01

    Contemporary scenography often consists of video-projected motion graphics. The field is lacking in academic methods and rigour: descriptions and models relevant for the creation as well as in the analysis of existing works. In order to understand the phenomenon of motion graphics in a scenographic...... construction as a support to working systematically practice-led research project. The design model is being developed through design laboratories and workshops with students and professionals who provide feedback that lead to incremental improvements. Working with this model construction-as-method reveals...

  1. Methods of visualizing graphs

    Science.gov (United States)

    Wong, Pak C.; Mackey, Patrick S.; Perrine, Kenneth A.; Foote, Harlan P.; Thomas, James J.

    2008-12-23

    Methods for visualizing a graph by automatically drawing elements of the graph as labels are disclosed. In one embodiment, the method comprises receiving node information and edge information from an input device and/or communication interface, constructing a graph layout based at least in part on that information, wherein the edges are automatically drawn as labels, and displaying the graph on a display device according to the graph layout. In some embodiments, the nodes are automatically drawn as labels instead of, or in addition to, the label-edges.

  2. Methods of Multivariate Analysis

    CERN Document Server

    Rencher, Alvin C

    2012-01-01

    Praise for the Second Edition "This book is a systematic, well-written, well-organized text on multivariate analysis packed with intuition and insight . . . There is much practical wisdom in this book that is hard to find elsewhere."-IIE Transactions Filled with new and timely content, Methods of Multivariate Analysis, Third Edition provides examples and exercises based on more than sixty real data sets from a wide variety of scientific fields. It takes a "methods" approach to the subject, placing an emphasis on how students and practitioners can employ multivariate analysis in real-life sit

  3. Methods for pretreating biomass

    Science.gov (United States)

    Balan, Venkatesh; Dale, Bruce E; Chundawat, Shishir; Sousa, Leonardo

    2017-05-09

    A method for pretreating biomass is provided, which includes, in a reactor, allowing gaseous ammonia to condense on the biomass and react with water present in the biomass to produce pretreated biomass, wherein reactivity of polysaccharides in the biomass is increased during subsequent biological conversion as compared to the reactivity of polysaccharides in biomass which has not been pretreated. A method for pretreating biomass with a liquid ammonia and recovering the liquid ammonia is also provided. Related systems which include a biochemical or biofuel production facility are also disclosed.

  4. Apoptosis - Methods and Protocols

    Directory of Open Access Journals (Sweden)

    CarloAlberto Redi

    2010-03-01

    Full Text Available Apoptosis - Methods and ProtocolsSecond edition, 2009; Peter Erhardt and Ambrus Toth (Eds; Springer Protocols - Methods in molecular biology, vol. 559; Humana press, Totowa, New Jersey (USA; Pages: 400; €88.35; ISBN: 978-1-60327-016-8The editors rightly begin the preface telling us that: “The ability to detect and quantify apoptosis, to understand its biochemistry and to identify its regulatory genes and proteins is crucial to biomedical research”. Nowadays this is a grounding concept of biology and medicine. What is particularly remarkable...

  5. Practical methods of optimization

    CERN Document Server

    Fletcher, R

    2013-01-01

    Fully describes optimization methods that are currently most valuable in solving real-life problems. Since optimization has applications in almost every branch of science and technology, the text emphasizes their practical aspects in conjunction with the heuristics useful in making them perform more reliably and efficiently. To this end, it presents comparative numerical studies to give readers a feel for possibile applications and to illustrate the problems in assessing evidence. Also provides theoretical background which provides insights into how methods are derived. This edition offers rev

  6. Essential numerical computer methods

    CERN Document Server

    Johnson, Michael L

    2010-01-01

    The use of computers and computational methods has become ubiquitous in biological and biomedical research. During the last 2 decades most basic algorithms have not changed, but what has is the huge increase in computer speed and ease of use, along with the corresponding orders of magnitude decrease in cost. A general perception exists that the only applications of computers and computer methods in biological and biomedical research are either basic statistical analysis or the searching of DNA sequence data bases. While these are important applications they only scratch the surface

  7. Analogue computing methods

    CERN Document Server

    Welbourne, D

    1965-01-01

    Analogue Computing Methods presents the field of analogue computation and simulation in a compact and convenient form, providing an outline of models and analogues that have been produced to solve physical problems for the engineer and how to use and program the electronic analogue computer. This book consists of six chapters. The first chapter provides an introduction to analogue computation and discusses certain mathematical techniques. The electronic equipment of an analogue computer is covered in Chapter 2, while its use to solve simple problems, including the method of scaling is elaborat

  8. Making Methods Choices.

    Science.gov (United States)

    Patton, Michael Quinn

    1980-01-01

    Methodological paradigms in evaluation research are discussed. This article is a response to the attacks on paradigmatic perspectives made by Reichardt and Cook in the opening chapter of their edited book, "Qualitative and Quantitative Methods in Evaluation Research." (Author/GK)

  9. communication method and apparatus

    DEFF Research Database (Denmark)

    2005-01-01

    The present invention relates to a non-lingual communication method and apparatus, wherein a physical or physiological signal consciously created by a first subject (1) is detected and converted into a transmitted output signal presented to a second subject (7) in order to communicate information...

  10. METHOD OF CENTRIFUGE OPERATION

    Science.gov (United States)

    Cohen, K.

    1960-05-10

    A method of isotope separation is described in which two streams are flowed axially of, and countercurrently through, a cylindrical centrifuge bowl. Under the influence of a centrifugal field, the light fraction is concentrated in a stream flowing through the central portion of the bowl, whereas the heavy fraction is concentrated in a stream at the periphery thereof.

  11. Ferrari's Method and Technology

    Science.gov (United States)

    Althoen, Steve

    2005-01-01

    Some tips that combine knowledge of mathematics history and technology for adapting Ferrar's method to factor quintics with a TI-83 graphing calculator are presented. A demonstration on the use of the root finder and regression capabilities of the graphing calculator are presented, so that the tips can be easily adapted for any graphing calculator…

  12. The Mnemonic Keyword Method.

    Science.gov (United States)

    Pressley, Michael; And Others

    1982-01-01

    Available experimental evidence is reviewed concerning the keyword method, a two-stage procedure for remembering materials having an associative component. The review examines subjects' memory for definitions, given vocabulary words; subjects' learning of other aspects of vocabulary, given definitions; group-administered keyword studies; and…

  13. Modern Reduction Methods

    CERN Document Server

    Andersson, Pher G

    2008-01-01

    With its comprehensive overview of modern reduction methods, this book features high quality contributions allowing readers to find reliable solutions quickly and easily. The monograph treats the reduction of carbonyles, alkenes, imines and alkynes, as well as reductive aminations and cross and heck couplings, before finishing off with sections on kinetic resolutions and hydrogenolysis. An indispensable lab companion for every chemist.

  14. Analysis of numerical methods

    CERN Document Server

    Isaacson, Eugene

    1994-01-01

    This excellent text for advanced undergraduates and graduate students covers norms, numerical solution of linear systems and matrix factoring, iterative solutions of nonlinear equations, eigenvalues and eigenvectors, polynomial approximation, and other topics. It offers a careful analysis and stresses techniques for developing new methods, plus many examples and problems. 1966 edition.

  15. The Method of "Currere."

    Science.gov (United States)

    Pinar, William Frederick

    In this presentation the author paints a conceptual portrait of his evolving relationships to his formal studies and thereby describes a method by which educators can reconceptualize the meaning of curriculum. By taking oneself and one's existential experience as a data source and using the psychoanalytical technique of free association, one can…

  16. Universal Image Steganalytic Method

    Directory of Open Access Journals (Sweden)

    V. Banoci

    2014-12-01

    Full Text Available In the paper we introduce a new universal steganalytic method in JPEG file format that is detecting well-known and also newly developed steganographic methods. The steganalytic model is trained by MHF-DZ steganographic algorithm previously designed by the same authors. The calibration technique with the Feature Based Steganalysis (FBS was employed in order to identify statistical changes caused by embedding a secret data into original image. The steganalyzer concept utilizes Support Vector Machine (SVM classification for training a model that is later used by the same steganalyzer in order to identify between a clean (cover and steganographic image. The aim of the paper was to analyze the variety in accuracy of detection results (ACR while detecting testing steganographic algorithms as F5, Outguess, Model Based Steganography without deblocking, JP Hide and Seek which represent the generally used steganographic tools. The comparison of four feature vectors with different lengths FBS (22, FBS (66 FBS(274 and FBS(285 shows promising results of proposed universal steganalytic method comparing to binary methods.

  17. Methods Evolved by Observation

    Science.gov (United States)

    Montessori, Maria

    2016-01-01

    Montessori's idea of the child's nature and the teacher's perceptiveness begins with amazing simplicity, and when she speaks of "methods evolved," she is unveiling a methodological system for observation. She begins with the early childhood explosion into writing, which is a familiar child phenomenon that Montessori has written about…

  18. Method card design dimensions

    DEFF Research Database (Denmark)

    Wölfel, Christiane; Merritt, T.

    2013-01-01

    . The card-based tools are explained in terms of five design dimensions including the intended purpose and scope of use, duration of use, methodology, customization, and formal/material qualities. Our analysis suggests three design patterns or archetypes for existing card-based design method tools...

  19. Statistical methods in astronomy

    OpenAIRE

    Long, James P.; de Souza, Rafael S.

    2017-01-01

    We present a review of data types and statistical methods often encountered in astronomy. The aim is to provide an introduction to statistical applications in astronomy for statisticians and computer scientists. We highlight the complex, often hierarchical, nature of many astronomy inference problems and advocate for cross-disciplinary collaborations to address these challenges.

  20. Methods of materiality

    DEFF Research Database (Denmark)

    Aagaard, Jesper; Matthiesen, Noomi

    2016-01-01

    , and the method of participant observation is suggested as a viable approach to achieve this end. An empirical example of how authority is produced in a parent-teacher conference, not only through language but also through material objects and embodied being, is then presented. The article concludes by suggesting...

  1. Research Methods in Sociolinguistics

    Science.gov (United States)

    Hernández-Campoy, Juan Manuel

    2014-01-01

    The development of Sociolinguistics has been qualitatively and quantitatively outstanding within Linguistic Science since its beginning in the 1950s, with a steady growth in both theoretical and methodological developments as well as in its interdisciplinary directions within the spectrum of language and society. Field methods in sociolinguistic…

  2. Ergonomics research methods

    Science.gov (United States)

    Uspenskiy, S. I.; Yermakova, S. V.; Chaynova, L. D.; Mitkin, A. A.; Gushcheva, T. M.; Strelkov, Y. K.; Tsvetkova, N. F.

    1973-01-01

    Various factors used in ergonomic research are given. They are: (1) anthrometric measurement, (2) polyeffector method of assessing the functional state of man, (3) galvanic skin reaction, (4) pneumography, (5) electromyography, (6) electrooculography, and (7) tachestoscopy. A brief summary is given of each factor and includes instrumentation and results.

  3. A method for sintering

    DEFF Research Database (Denmark)

    2012-01-01

    The present invention provides a method for sintering, comprising in the following order the steps of: providing a body in the green state or in the pre-sintered state on a support; providing a load on at least one spacer on the support such that the load is located above said body in the green...

  4. Biomass treatment method

    Science.gov (United States)

    Friend, Julie; Elander, Richard T.; Tucker, III; Melvin P.; Lyons, Robert C.

    2010-10-26

    A method for treating biomass was developed that uses an apparatus which moves a biomass and dilute aqueous ammonia mixture through reaction chambers without compaction. The apparatus moves the biomass using a non-compressing piston. The resulting treated biomass is saccharified to produce fermentable sugars.

  5. Truth and Methods.

    Science.gov (United States)

    Dasenbrock, Reed Way

    1995-01-01

    Examines literary theory's displacing of "method" in the New Historicist criticism. Argues that Stephen Greenblatt and Lee Paterson imply that no objective historical truth is possible and as a result do not give methodology its due weight in their criticism. Questions the theory of "truth" advanced in this vein of literary…

  6. Software specification methods

    CERN Document Server

    Habrias, Henri

    2010-01-01

    This title provides a clear overview of the main methods, and has a practical focus that allows the reader to apply their knowledge to real-life situations. The following are just some of the techniques covered: UML, Z, TLA+, SAZ, B, OMT, VHDL, Estelle, SDL and LOTOS.

  7. Progress in variational methods

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ The International Conference on Variational Methods (ICVAM) was held from May 20th to 26th in 2007 at the Chern Institute of Mathematics, Nankai University, Tianjin, China. Twenty eight invited speakers from ten countries and areas worldwide gave their lectures at the conference.

  8. Heart imaging method

    Science.gov (United States)

    Collins, H. Dale; Gribble, R. Parks; Busse, Lawrence J.

    1991-01-01

    A method for providing an image of the human heart's electrical system derives time-of-flight data from an array of EKG electrodes and this data is transformed into phase information. The phase information, treated as a hologram, is reconstructed to provide an image in one or two dimensions of the electrical system of the functioning heart.

  9. Quality of regularization methods

    NARCIS (Netherlands)

    Bouwman, J.

    1998-01-01

    The solution of ill-posed problems is non-trivial in the sense that frequently applied methods like least-squares fail. The ill-posedness of the problem is refiected by very small changes in the input data which may result in very large changes in the output data. Hence, some sort of stabilization

  10. Methods of materiality

    DEFF Research Database (Denmark)

    Aagaard, Jesper; Matthiesen, Noomi

    2016-01-01

    , and the method of participant observation is suggested as a viable approach to achieve this end. An empirical example of how authority is produced in a parent-teacher conference, not only through language but also through material objects and embodied being, is then presented. The article concludes by suggesting...

  11. Proven Weight Loss Methods

    Science.gov (United States)

    Fact Sheet Proven Weight Loss Methods What can weight loss do for you? Losing weight can improve your health in a number of ways. ... limiting calories) usually isn’t enough to cause weight loss. But exercise plays an important part in helping ...

  12. Research Methods in Sociolinguistics

    Science.gov (United States)

    Hernández-Campoy, Juan Manuel

    2014-01-01

    The development of Sociolinguistics has been qualitatively and quantitatively outstanding within Linguistic Science since its beginning in the 1950s, with a steady growth in both theoretical and methodological developments as well as in its interdisciplinary directions within the spectrum of language and society. Field methods in sociolinguistic…

  13. Sampling system and method

    Science.gov (United States)

    Decker, David L.; Lyles, Brad F.; Purcell, Richard G.; Hershey, Ronald Lee

    2013-04-16

    The present disclosure provides an apparatus and method for coupling conduit segments together. A first pump obtains a sample and transmits it through a first conduit to a reservoir accessible by a second pump. The second pump further conducts the sample from the reservoir through a second conduit.

  14. Photothermal methods in medicine

    Science.gov (United States)

    Murphy, John C.

    2000-10-01

    Photothermal imaging and spectroscopy are being applied to a variety of medical problems for diagnosis and therapy. This paper reviews some aspects of this field including the opportunities presented by non-optical sources and by use of detection methods targeted to the application.

  15. Quality of regularization methods

    NARCIS (Netherlands)

    Bouwman, J.

    1998-01-01

    The solution of ill-posed problems is non-trivial in the sense that frequently applied methods like least-squares fail. The ill-posedness of the problem is refiected by very small changes in the input data which may result in very large changes in the output data. Hence, some sort of stabilization o

  16. Project execution methods

    National Research Council Canada - National Science Library

    John C Pfeiffer

    2004-01-01

      In the design/build (D/B) method of implementing plant construction projects, the owner contracts with the engineer/contractor or contractor/engineer company or team-depending upon who takes the lead in the project to develop...

  17. The Effective Equation Method

    Science.gov (United States)

    Kuksin, Sergei; Maiocchi, Alberto

    In this chapter we present a general method of constructing the effective equation which describes the behavior of small-amplitude solutions for a nonlinear PDE in finite volume, provided that the linear part of the equation is a hamiltonian system with a pure imaginary discrete spectrum. The effective equation is obtained by retaining only the resonant terms of the nonlinearity (which may be hamiltonian, or may be not); the assertion that it describes the limiting behavior of small-amplitude solutions is a rigorous mathematical theorem. In particular, the method applies to the three- and four-wave systems. We demonstrate that different possible types of energy transport are covered by this method, depending on whether the set of resonances splits into finite clusters (this happens, e.g. in case of the Charney-Hasegawa-Mima equation), or is connected (this happens, e.g. in the case of the NLS equation if the space-dimension is at least two). For equations of the first type the energy transition to high frequencies does not hold, while for equations of the second type it may take place. Our method applies to various weakly nonlinear wave systems, appearing in plasma, meteorology and oceanography.

  18. Teaching Materials and Methods.

    Science.gov (United States)

    Physiologist, 1987

    1987-01-01

    Contains abstracts of presented papers which deal with teaching materials and methods in physiology. Includes papers on preconceptual notions in physiology, somatosensory activity recorded in the dorsal root ganglion of the bull frog, and the use of the Apple Macintosh microcomputer in teaching human anatomy and physiology. (TW)

  19. Photovoltaic device and method

    Science.gov (United States)

    Cleereman, Robert; Lesniak, Michael J.; Keenihan, James R.; Langmaid, Joe A.; Gaston, Ryan; Eurich, Gerald K.; Boven, Michelle L.

    2015-11-24

    The present invention is premised upon an improved photovoltaic device ("PVD") and method of use, more particularly to an improved photovoltaic device with an integral locator and electrical terminal mechanism for transferring current to or from the improved photovoltaic device and the use as a system.

  20. Water-budget methods

    Science.gov (United States)

    Healy, Richard W.; Scanlon, Bridget R.

    2010-01-01

    A water budget is an accounting of water movement into and out of, and storage change within, some control volume. Universal and adaptable are adjectives that reflect key features of water-budget methods for estimating recharge. The universal concept of mass conservation of water implies that water-budget methods are applicable over any space and time scales (Healy et al., 2007). The water budget of a soil column in a laboratory can be studied at scales of millimeters and seconds. A water-budget equation is also an integral component of atmospheric general circulation models used to predict global climates over periods of decades or more. Water-budget equations can be easily customized by adding or removing terms to accurately portray the peculiarities of any hydrologic system. The equations are generally not bound by assumptions on mechanisms by which water moves into, through, and out of the control volume of interest. So water-budget methods can be used to estimate both diffuse and focused recharge, and recharge estimates are unaffected by phenomena such as preferential flow paths within the unsaturated zone. Water-budget methods represent the largest class of techniques for estimating recharge. Most hydrologic models are derived from a water-budget equation and can therefore be classified as water-budget models. It is not feasible to address all water-budget methods in a single chapter. This chapter is limited to discussion of the “residual” water-budget approach, whereby all variables in a water-budget equation, except for recharge, are independently measured or estimated and recharge is set equal to the residual. This chapter is closely linked with Chapter 3, on modeling methods, because the equations presented here form the basis of many models and because models are often used to estimate individual components in water-budget studies. Water budgets for streams and other surface-water bodies are addressed in Chapter 4. The use of soil-water budgets and

  1. Nonhazardous Urine Pretreatment Method

    Science.gov (United States)

    Akse, James R.; Holtsnider, John T.

    2012-01-01

    A method combines solid phase acidification with two non-toxic biocides to prevent ammonia volatilization and microbial proliferation. The safe, non-oxidizing biocide combination consists of a quaternary amine and a food preservative. This combination has exhibited excellent stabilization of both acidified and unacidified urine. During pretreatment tests, composite urine collected from donors was challenged with a microorganism known to proliferate in urine, and then was processed using the nonhazardous urine pre-treatment method. The challenge microorganisms included Escherichia coli, a common gram-negative bacteria; Enterococcus faecalis, a ureolytic gram-positive bacteria; Candida albicans, a yeast commonly found in urine; and Aspergillus niger, a problematic mold that resists urine pre-treatment. Urine processed in this manner remained microbially stable for over 57 days. Such effective urine stabilization was achieved using non-toxic, non-oxidizing biocides at higher pH (3.6 to 5.8) than previous methods in use or projected for use aboard the International Space Station (ISS). ISS urine pretreatment methods employ strong oxidants including ozone and hexavalent chromium (Cr(VI)), a carcinogenic material, under very acidic conditions (pH = 1.8 to 2.4). The method described here offers a much more benign chemical environment than previous pretreatment methods, and will lower equivalent system mass (ESM) by reducing containment volume and mass, system complexity, and crew time needed to handle pre-treatment chemicals. The biocides, being non-oxidizing, minimize the potential for chemical reactions with urine constituents to produce volatile, airborne contaminants such as cyanogen chloride. Additionally, the biocides are active under significantly less acidic conditions than those used in the current system, thereby reducing the degree of required acidification. A simple flow-through solid phase acidification (SPA) bed is employed to overcome the natural buffering

  2. Developments in Surrogating Methods

    Directory of Open Access Journals (Sweden)

    Hans van Dormolen

    2005-11-01

    Full Text Available In this paper, I would like to talk about the developments in surrogating methods for preservation. My main focus will be on the technical aspects of preservation surrogates. This means that I will tell you something about my job as Quality Manager Microfilming for the Netherlands’ national preservation program, Metamorfoze, which is coordinated by the National Library. I am responsible for the quality of the preservation microfilms, which are produced for Metamorfoze. Firstly, I will elaborate on developments in preservation methods in relation to the following subjects: · Preservation microfilms · Scanning of preservation microfilms · Preservation scanning · Computer Output Microfilm. In the closing paragraphs of this paper, I would like to tell you something about the methylene blue test. This is an important test for long-term storage of preservation microfilms. Also, I will give you a brief report on the Cellulose Acetate Microfilm Conference that was held in the British Library in London, May 2005.

  3. Motor degradation prediction methods

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, J.R.; Kelly, J.F.; Delzingaro, M.J.

    1996-12-01

    Motor Operated Valve (MOV) squirrel cage AC motor rotors are susceptible to degradation under certain conditions. Premature failure can result due to high humidity/temperature environments, high running load conditions, extended periods at locked rotor conditions (i.e. > 15 seconds) or exceeding the motor`s duty cycle by frequent starts or multiple valve stroking. Exposure to high heat and moisture due to packing leaks, pressure seal ring leakage or other causes can significantly accelerate the degradation. ComEd and Liberty Technologies have worked together to provide and validate a non-intrusive method using motor power diagnostics to evaluate MOV rotor condition and predict failure. These techniques have provided a quick, low radiation dose method to evaluate inaccessible motors, identify degradation and allow scheduled replacement of motors prior to catastrophic failures.

  4. Mitosis Methods & Protocols

    Directory of Open Access Journals (Sweden)

    CarloAlberto Redi

    2010-06-01

    Full Text Available Mitosis Methods & Protocols Andrew D. McAinsh (Edt Humana press, Totowa, New Jersey (USA Series: Springer Protocols Methods in Molecular Biology, Volume 545, 2009 ISBN: 978-1-60327-992-5   It is quite clear from the contents of this book that the remarkably fascinating phenomenon of mitosis (that captured, and still is capturing, the attention of entire generations of scientists is still open to research. This is mainly due to our lack of knowledge of so many multifaced events of this extraordinarly complex process. The reader giving a glace through the Contents and Contributors sections is speechless: All of the first-class models (i.e., budding yeast, Caenorabditis, Drosophila, Xenopus and Human are presented..... 

  5. Method card design dimensions

    DEFF Research Database (Denmark)

    Wölfel, Christiane; Merritt, T.

    2013-01-01

    . The card-based tools are explained in terms of five design dimensions including the intended purpose and scope of use, duration of use, methodology, customization, and formal/material qualities. Our analysis suggests three design patterns or archetypes for existing card-based design method tools...... and highlights unexplored areas in the design space. The paper concludes with recommendations for the future development of card-based methods for the field of interaction design.......There are many examples of cards used to assist or provide structure to the design process, yet there has not been a thorough articulation of the strengths and weaknesses of the various examples. We review eighteen card-based design tools in order to understand how they might benefit designers...

  6. Jet vortex methods

    CERN Document Server

    Holm, Darryl D

    2015-01-01

    Vortex blob methods are typically characterized by a regularization length scale, below which the the dynamics are trivial for isolated blobs. In this article we will find that the dynamics need not be trivial if one is willing to consider distributional derivatives of Dirac delta functionals as valid vorticity distributions. More specifically, a new singular vortex theory is presented for regularised Euler fluid equations of ideal incompressible flow in the plane. We determine the conditions under which such regularised Euler fluid equations may admit vorticity singularities which are stronger than delta functions, e.g., derivatives of delta functions. We also characterise the Hamiltonian dynamics of the higher-order singular vortices. Applications to the design of numerical meth- ods similar to vortex blob methods are also discussed. Such findings shed light onto the rich dynamics which occur below the regularization length scale and enlighten our perspective on the multiscale aspects of regularized fluid m...

  7. The Montessori Method

    Directory of Open Access Journals (Sweden)

    Cathleen Haskins

    2010-06-01

    Full Text Available Dr. Maria Montessori provided the world with a powerful philosophy and practice for the advancement of humanity: change how we educate children and we change the world. She understood two things very clearly: One, that we can build a better world, a more just and peaceful place, when we educate for the realization of the individual and collective human potential; and two, that the only way to create an educational system that will that will serve this end is to scrap the current system entirely and replace it with a completely new system. She gave us a system through which to accomplish that goal: The Montessori Method. The following is a personal and professional account of the Montessori Method of educating children.

  8. in the DSMC Method

    Directory of Open Access Journals (Sweden)

    Fong-Zhi Chen

    2001-01-01

    Full Text Available In this study, the Plücker coordinates representation is used to formulate the ruled surface and the molecular path for pumping speed performance evaluation of a molecular vacuum pump. The ruled surface represented by the Pliicker coordinates is used to develop a criterion for when gas molecules hit the pump surface wall. The criterion is applied to analyze the flow rate of a new developed vacuum pump in transition regimes by using the DSMC (Direct Simulation Monte Carlo method. When a molecule flies in a neutral electrical field its path is a straight line. If the molecular path and the generators of a ruled surface are both represented by the Pliicker coordinates, the position of the molecular hit on the wall can be verified by the reciprocal condition of the lines. The Plücker coordinates representation is quite convenient in the DSMC method for this three-dimensional molecular flow simulation.

  9. Anthropological methods in ethnopharmacology.

    Science.gov (United States)

    Etkin, N L

    1993-03-01

    This paper reviews anthropological methods in ethnopharmacology to advance a critical and biobehavioral perspective for the construction of primary data in the light of indigenous paradigms of health and therapeutics. The unique contributions of anthropology are the conceptual and practical tools that allow one to develop the ethnography of plant use in sufficient depth to correlate with laboratory and clinical investigations of plant constituents and activities. This serves an ethnopharmacology that links bioscientific research to traditional empirical knowledge. Specific methods discussed include: key respondents, participant observation, focus groups, structured and unstructured interviews, survey instruments and questionnaires, lexical and semantic studies, and discourse and content analysis. The accommodation of rapid ethnographic techniques for ethnopharmacologic research is described, and several problem orientations based on assessments of efficacy are offered.

  10. INNOVATIVE SALES METHODS

    Directory of Open Access Journals (Sweden)

    Roxana L. IONESCU

    2014-06-01

    Full Text Available Companies operating in a global economy that is constantly changing and developming, especially during the financial crisis and political instability. It is necessary to adapt and develop sales methods in such environment. For large companies who base their activity on sales it has become a necessity to learn different types of sales approaches because their knowledge enables them to grow the number of customers and therefore the sales and the turnover. This paper aims to exame the most effective sales methods used on the highly sensitive economic and social environment – the insurance market. In the field of insurances, the sales process is even more important because sellers need to sell an intangible product that may materialize in the future, but there is no certainty.

  11. Dynamic encryption method

    DEFF Research Database (Denmark)

    2013-01-01

    Disclosed is a method of transmitting a data set using encryption, wherein the method comprises the steps of: selecting a first encryption technique, wherein said first encryption technique comprises a first encryption algorithm for encrypting plain data into cipher data, and a first decryption...... algorithm for on provision of a specific key, decrypting cipher data and reproduce plain data; encrypting the first data package comprising plain data, using a first encryption program implementing the first encryption algorithm of said first encryption technique, creating a first encrypted data package...... comprising cipher data; obtaining a first decryption program; and transmitting said first decryption program and said first encrypted data package to a receiver, wherein the first decryption, upon provision of the specific key and the first encrypted data package, will decrypt the cipher data in the first...

  12. by Lifting Line Method

    Directory of Open Access Journals (Sweden)

    Horia Dumitrescu

    1998-01-01

    Full Text Available The vortex model of propellers is modified and applied to the high-speed horizontal axis turbines. The turbine blades are replaced by lifting lines and trailing vortices which shed along the blade span. The model is not a free wake model, but it is still a nonlinear one which should be solved iteratively. In addition to the regular case where the trailing vortices are constrained to distribute along a helical surface, another version, where each trailing vortex sheding from the blade grows as a free helical vortex line, is also included. Performance parameters are calculated by application of the Biot-Savart law along with the Kutta-Joukowski theorem. Predictions are, shown to compare favorably with existing numerical data from more involved free wake methods, but require less computational effort. Thereby, the present method may be a very useful tool for calculating the aerodynamic loads on horizontal-axis wind turbine blades.

  13. THE ACTION RESEARCH METHOD

    Directory of Open Access Journals (Sweden)

    Petre GEORGIEVSKI

    1999-05-01

    Full Text Available The effort in this work to elaborate an action research method as a central research problem considering the recent contemporary sociological and educa­tional literature. The author begins with the statement that the method is a complex notion, composed of three main components: approach to the research problem, data gathering procedures and data analysis procedures. This point of view is further applied and elaborated in the author's text, emphasizing the action research characteristics: interruption with the positive tradition in social research and the divided of the objective and subjective, application of the qualitative data. The sub­stantial difference between the action research in regard with the other kinds of research, is not only in getting to new knowledge's, but also in problem solving or a change in the situation in a concrete social context.

  14. Nanoscale waveguiding methods.

    Science.gov (United States)

    Wang, Chia-Jean; Lin, Lih Y

    2007-05-01

    While 32 nm lithography technology is on the horizon for integrated circuit (IC) fabrication, matching the pace for miniaturization with optics has been hampered by the diffraction limit. However, development of nanoscale components and guiding methods is burgeoning through advances in fabrication techniques and materials processing. As waveguiding presents the fundamental issue and cornerstone for ultra-high density photonic ICs, we examine the current state of methods in the field. Namely, plasmonic, metal slot and negative dielectric based waveguides as well as a few sub-micrometer techniques such as nanoribbons, high-index contrast and photonic crystals waveguides are investigated in terms of construction, transmission, and limitations. Furthermore, we discuss in detail quantum dot (QD) arrays as a gain-enabled and flexible means to transmit energy through straight paths and sharp bends. Modeling, fabrication and test results are provided and show that the QD waveguide may be effective as an alternate means to transfer light on sub-diffraction dimensions.

  15. Methods for forming particles

    Energy Technology Data Exchange (ETDEWEB)

    Fox, Robert V.; Zhang, Fengyan; Rodriguez, Rene G.; Pak, Joshua J.; Sun, Chivin

    2016-06-21

    Single source precursors or pre-copolymers of single source precursors are subjected to microwave radiation to form particles of a I-III-VI.sub.2 material. Such particles may be formed in a wurtzite phase and may be converted to a chalcopyrite phase by, for example, exposure to heat. The particles in the wurtzite phase may have a substantially hexagonal shape that enables stacking into ordered layers. The particles in the wurtzite phase may be mixed with particles in the chalcopyrite phase (i.e., chalcopyrite nanoparticles) that may fill voids within the ordered layers of the particles in the wurtzite phase thus produce films with good coverage. In some embodiments, the methods are used to form layers of semiconductor materials comprising a I-III-VI.sub.2 material. Devices such as, for example, thin-film solar cells may be fabricated using such methods.

  16. Methods for forming particles

    Science.gov (United States)

    Fox, Robert V.; Zhang, Fengyan; Rodriguez, Rene G.; Pak, Joshua J.; Sun, Chivin

    2016-06-21

    Single source precursors or pre-copolymers of single source precursors are subjected to microwave radiation to form particles of a I-III-VI.sub.2 material. Such particles may be formed in a wurtzite phase and may be converted to a chalcopyrite phase by, for example, exposure to heat. The particles in the wurtzite phase may have a substantially hexagonal shape that enables stacking into ordered layers. The particles in the wurtzite phase may be mixed with particles in the chalcopyrite phase (i.e., chalcopyrite nanoparticles) that may fill voids within the ordered layers of the particles in the wurtzite phase thus produce films with good coverage. In some embodiments, the methods are used to form layers of semiconductor materials comprising a I-III-VI.sub.2 material. Devices such as, for example, thin-film solar cells may be fabricated using such methods.

  17. The random projection method

    CERN Document Server

    Vempala, Santosh S

    2005-01-01

    Random projection is a simple geometric technique for reducing the dimensionality of a set of points in Euclidean space while preserving pairwise distances approximately. The technique plays a key role in several breakthrough developments in the field of algorithms. In other cases, it provides elegant alternative proofs. The book begins with an elementary description of the technique and its basic properties. Then it develops the method in the context of applications, which are divided into three groups. The first group consists of combinatorial optimization problems such as maxcut, graph coloring, minimum multicut, graph bandwidth and VLSI layout. Presented in this context is the theory of Euclidean embeddings of graphs. The next group is machine learning problems, specifically, learning intersections of halfspaces and learning large margin hypotheses. The projection method is further refined for the latter application. The last set consists of problems inspired by information retrieval, namely, nearest neig...

  18. Glycoconjugates and methods

    Energy Technology Data Exchange (ETDEWEB)

    Bertozzi, Carolyn C. (Albany, CA); Yarema, Kevin J. (Albany, CA); Mahal; Lara K. (Berkeley, CA)

    2008-04-01

    Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (iii) conjugates the saccharide to a carrier to form a glycoconjugate, and (iv) extracellularly expresses the glycoconjugate to form an extracellular glycoconjugate comprising a selectively reactive functional group. Methods for forming products at a cell further comprise contacting the functional group of the extracellularly expressed glycoconjugate with an agent which selectively reacts with the functional group to form a product. Subject compositions include cyto-compatible monosaccharides comprising a nitrogen or ether linked functional group selectively reactive at a cell surface and compositions and cells comprising such saccharides.

  19. Statistical Methods for Astronomy

    CERN Document Server

    Feigelson, Eric D

    2012-01-01

    This review outlines concepts of mathematical statistics, elements of probability theory, hypothesis tests and point estimation for use in the analysis of modern astronomical data. Least squares, maximum likelihood, and Bayesian approaches to statistical inference are treated. Resampling methods, particularly the bootstrap, provide valuable procedures when distributions functions of statistics are not known. Several approaches to model selection and good- ness of fit are considered. Applied statistics relevant to astronomical research are briefly discussed: nonparametric methods for use when little is known about the behavior of the astronomical populations or processes; data smoothing with kernel density estimation and nonparametric regression; unsupervised clustering and supervised classification procedures for multivariate problems; survival analysis for astronomical datasets with nondetections; time- and frequency-domain times series analysis for light curves; and spatial statistics to interpret the spati...

  20. MIXED METHOD RESEARCH

    Directory of Open Access Journals (Sweden)

    Masrizal Masrizal

    2012-03-01

    Full Text Available Mixed Method Research adalah metode penelitian yang diaplikasikan bila peneliti memiliki pertanyaan yang perlu diuji dari segi outcomes dan prosesnya, serta menyangkut kombinasi antara metode kuantitatif dan kualitatif dalam satu penelitian. Karena berfokus pada outcomes dan proses, maka desain MMR biasa digunakan dalam penelitian evaluasi program. Namun sekarang, MMR sudah sering digunakan untuk ilmu-ilmu sosial, seperti: konseling, psikologi social manajemen, dan pengorganisasian perilaku.

  1. MIXED METHOD RESEARCH

    OpenAIRE

    Masrizal Masrizal

    2012-01-01

    Mixed Method Research adalah metode penelitian yang diaplikasikan bila peneliti memiliki pertanyaan yang perlu diuji dari segi outcomes dan prosesnya, serta menyangkut kombinasi antara metode kuantitatif dan kualitatif dalam satu penelitian. Karena berfokus pada outcomes dan proses, maka desain MMR biasa digunakan dalam penelitian evaluasi program. Namun sekarang, MMR sudah sering digunakan untuk ilmu-ilmu sosial, seperti: konseling, psikologi social manajemen, dan pengorganisasian perilaku.

  2. Method for scavenging mercury

    Science.gov (United States)

    Chang, Shih-ger; Liu, Shou-heng; Liu, Zhao-rong; Yan, Naiqiang

    2009-01-20

    Disclosed herein is a method for removing mercury from a gas stream comprising contacting the gas stream with a getter composition comprising bromine, bromochloride, sulphur bromide, sulphur dichloride or sulphur monochloride and mixtures thereof. In one preferred embodiment the getter composition is adsorbed onto a sorbent. The sorbent may be selected from the group consisting of flyash, limestone, lime, calcium sulphate, calcium sulfite, activated carbon, charcoal, silicate, alumina and mixtures thereof. Preferred is flyash, activated carbon and silica.

  3. Statokinesigram normalization method.

    Science.gov (United States)

    de Oliveira, José Magalhães

    2017-02-01

    Stabilometry is a technique that aims to study the body sway of human subjects, employing a force platform. The signal obtained from this technique refers to the position of the foot base ground-reaction vector, known as the center of pressure (CoP). The parameters calculated from the signal are used to quantify the displacement of the CoP over time; there is a large variability, both between and within subjects, which prevents the definition of normative values. The intersubject variability is related to differences between subjects in terms of their anthropometry, in conjunction with their muscle activation patterns (biomechanics); and the intrasubject variability can be caused by a learning effect or fatigue. Age and foot placement on the platform are also known to influence variability. Normalization is the main method used to decrease this variability and to bring distributions of adjusted values into alignment. In 1996, O'Malley proposed three normalization techniques to eliminate the effect of age and anthropometric factors from temporal-distance parameters of gait. These techniques were adopted to normalize the stabilometric signal by some authors. This paper proposes a new method of normalization of stabilometric signals to be applied in balance studies. The method was applied to a data set collected in a previous study, and the results of normalized and nonnormalized signals were compared. The results showed that the new method, if used in a well-designed experiment, can eliminate undesirable correlations between the analyzed parameters and the subjects' characteristics and show only the experimental conditions' effects.

  4. Comments on PDF methods

    Science.gov (United States)

    Chen, J.-Y.

    1992-01-01

    Viewgraphs are presented on the following topics: the grand challenge of combustion engineering; research of probability density function (PDF) methods at Sandia; experiments of turbulent jet flames (Masri and Dibble, 1988); departures from chemical equilibrium; modeling turbulent reacting flows; superequilibrium OH radical; pdf modeling of turbulent jet flames; scatter plot for CH4 (methane) and O2 (oxygen); methanol turbulent jet flames; comparisons between predictions and experimental data; and turbulent C2H4 jet flames.

  5. Situational method engineering

    CERN Document Server

    Henderson-Sellers, Brian; Ågerfalk, Pär J; Rossi, Matti

    2014-01-01

    While previously available methodologies for software ? like those published in the early days of object technology ? claimed to be appropriate for every conceivable project, situational method engineering (SME) acknowledges that most projects typically have individual characteristics and situations. Thus, finding the most effective methodology for a particular project needs specific tailoring to that situation. Such a tailored software development methodology needs to take into account all the bits and pieces needed for an organization to develop software, including the software process, the

  6. Polymer compositions and methods

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Scott D.; Willkomm, Wayne R.

    2016-09-27

    The present invention encompasses polyurethane compositions comprising aliphatic polycarbonate chains. In one aspect, the present invention encompasses polyurethane foams, thermoplastics and elastomers derived from aliphatic polycarbonate polyols and polyisocyanates wherein the polyol chains contain a primary repeating unit having a structure: ##STR00001## In another aspect, the invention provides articles comprising the inventive foam and elastomer compositions as well as methods of making such compositions.

  7. Nearshore Pipeline Installation Methods.

    Science.gov (United States)

    1981-08-01

    179. 5. Aldridge, R. G., and Bomba , J. G., "Deep Water Pipelines - Interdependence of Design and Construction", ASCE Paper. 6. American Society Civil...October 13, 1967. 24. Bomba , J. G. and Seeds, K. J., "Pipelining in 600 feet of water .... A Case Study of Washington Natural Gas Company’s Puget Sound...Crossing", Offshore Technology Conference, paper OTC 1188, 1970. 25. Bomba , J., "Submarine Pipe Construction Methods", Petroleum Engineer, Vol. 32

  8. Methods in Bioengineering

    CERN Document Server

    Rege, Kaushal

    2009-01-01

    Filling a critical gap in the current literature, this new resource presents practical, step-by-step methods to help you synthesize, characterize, biofunctionalize and apply the nanomaterial that is most suitable for handling a given nanoscale bioengineering problem. Written and presented by leading scientists and engineers in their respective fields, the authors offer a clear and detailed understanding of how to carry out nanoparticle functionalization with biomolecules (including enzymes), nanoparticle analysis and characterization, in vitro evaluation of nanoparticles using different cell l

  9. Method of infusion extraction

    Science.gov (United States)

    Chang-Diaz, Franklin R. (Inventor)

    1989-01-01

    Apparatus and method of removing desirable constituents from an infusible material by infusion extraction, where a piston operating in a first chamber draws a solvent into the first chamber where it may be heated, and then moves the heated solvent into a second chamber containing the infusible material, and where infusion extraction takes place. The piston then moves the solvent containing the extract through a filter into the first chamber, leaving the extraction residue in the second chamber.

  10. Method for detecting biomolecules

    Science.gov (United States)

    Huo, Qisheng; Liu, Jun

    2008-08-12

    A method for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least one surface of the conducting electrode. The film is functionalized with probe molecules that chemically interact with the target biomolecules at the film surface, blocking indicator molecules present in solution from diffusing from the solution to the electrode, thereby changing the electrochemical response of the electrode

  11. Method for scavenging mercury

    Science.gov (United States)

    Chang, Shih-ger; Liu, Shou-heng; Liu, Zhao-rong; Yan, Naiqiang

    2010-07-13

    Disclosed herein is a method for removing mercury from a gas stream comprising contacting the gas stream with a getter composition comprising bromine, bromochloride, sulphur bromide, sulphur dichloride or sulphur monochloride and mixtures thereof. In one preferred embodiment the getter composition is adsorbed onto a sorbent. The sorbent may be selected from the group consisting flyash, limestone, lime, calcium sulphate, calcium sulfite, activated carbon, charcoal, silicate, alumina and mixtures thereof. Preferred is flyash, activated carbon and silica.

  12. Method of producing imines

    Science.gov (United States)

    Sithambaram, Shanthakumar; Son, Young-Chan; Suib, Steven L.

    2008-04-08

    A method for forming an imine comprises reacting a first reactant comprising a hydroxyl functionality, a carbonyl functionality, or both a hydroxyl functionality and a carbonyl functionality with a second reactant having an amine functionality in the presence of ordered porous manganese-based octahedral molecular sieves and an oxygen containing gas at a temperature and for a time sufficient for the imine to be produced.

  13. Methods in Bioengineering

    CERN Document Server

    Zahn, Jeffrey D

    2009-01-01

    This unique volume presents leading-edge microfluidics methods used to handle, manipulate, and analyze cells, particles, and biological components (e.g., proteins and DNA) for microdiagnostics. The authors offer clear and detailed guidance on microfabrication techniques utilized to create microfluidic devices and on-chip flow control and mixing Microsystems, protein and DNA handling devices for electrophoretic and isoelectric separations in microchromatography columns, microfluidic manipulations of droplets via electrowetting and particles via dielectrophoresis for separations and chemical rea

  14. Chromosome doubling method

    Science.gov (United States)

    Kato, Akio

    2006-11-14

    The invention provides methods for chromosome doubling in plants. The technique overcomes the low yields of doubled progeny associated with the use of prior techniques for doubling chromosomes in plants such as grasses. The technique can be used in large scale applications and has been demonstrated to be highly effective in maize. Following treatment in accordance with the invention, plants remain amenable to self fertilization, thereby allowing the efficient isolation of doubled progeny plants.

  15. Montessori Method and ICTs

    OpenAIRE

    Athanasios Drigas; Eugenia Gkeka

    2016-01-01

    This article bridges the gap between the Montessori Method and Information and Communication Technologies (ICTs) in contemporary education. It reviews recent research works which recall the Montessori philosophy, principles and didactical tools applying to today’s computers and supporting technologies in children’s learning process. This article reviews how important the stimulation of human senses in the learning process is, as well as the development of Montessori materials using the body a...

  16. Geometrical method of decoupling

    Science.gov (United States)

    Baumgarten, C.

    2012-12-01

    The computation of tunes and matched beam distributions are essential steps in the analysis of circular accelerators. If certain symmetries—like midplane symmetry—are present, then it is possible to treat the betatron motion in the horizontal, the vertical plane, and (under certain circumstances) the longitudinal motion separately using the well-known Courant-Snyder theory, or to apply transformations that have been described previously as, for instance, the method of Teng and Edwards. In a preceding paper, it has been shown that this method requires a modification for the treatment of isochronous cyclotrons with non-negligible space charge forces. Unfortunately, the modification was numerically not as stable as desired and it was still unclear, if the extension would work for all conceivable cases. Hence, a systematic derivation of a more general treatment seemed advisable. In a second paper, the author suggested the use of real Dirac matrices as basic tools for coupled linear optics and gave a straightforward recipe to decouple positive definite Hamiltonians with imaginary eigenvalues. In this article this method is generalized and simplified in order to formulate a straightforward method to decouple Hamiltonian matrices with eigenvalues on the real and the imaginary axis. The decoupling of symplectic matrices which are exponentials of such Hamiltonian matrices can be deduced from this in a few steps. It is shown that this algebraic decoupling is closely related to a geometric “decoupling” by the orthogonalization of the vectors E→, B→, and P→, which were introduced with the so-called “electromechanical equivalence.” A mathematical analysis of the problem can be traced down to the task of finding a structure-preserving block diagonalization of symplectic or Hamiltonian matrices. Structure preservation means in this context that the (sequence of) transformations must be symplectic and hence canonical. When used iteratively, the decoupling

  17. Electron cryomicroscopy methods.

    Science.gov (United States)

    Unger, V M

    2001-10-01

    Electron cryomicroscopy methods comprise a rapidly expanding field providing insights into the structure and function of biological macromolecules and their supramolecular assemblies. The 3.8 A resolution structure of the membrane protein aquaporin, a view of the herpesvirus capsid at 8.5 A and the 10 A resolution structure of the spliceosomal U1 small nuclear ribonucleoprotein complex are three outstanding examples emphasizing the versatility of this technique.

  18. Method for making nanomaterials

    Science.gov (United States)

    Fan, Hongyou; Wu, Huimeng

    2013-06-04

    A method of making a nanostructure by preparing a face centered cubic-ordered metal nanoparticle film from metal nanoparticles, such as gold and silver nanoparticles, exerting a hydrostatic pressure upon the film at pressures of several gigapascals, followed by applying a non-hydrostatic stress perpendicularly at a pressure greater than approximately 10 GPA to form an array of nanowires with individual nanowires having a relatively uniform length, average diameter and density.

  19. Bering Mission Navigation Method

    OpenAIRE

    2003-01-01

    "Bering", after the name of the famous Danish explorer, is a near Earth object (NEO) and main belt asteroids mapping mission envisaged by a consortium of Danish universities and research institutes. To achieve the ambitious goals set forth by this mission, while containing the costs and risks, "Bering" sports several new technological enhancements and advanced instruments under development at the Technical University of Denmark (DTU). The autonomous on-board orbit determination method is part...

  20. Methods of celestial mechanics

    CERN Document Server

    Brouwer, Dirk

    2013-01-01

    Methods of Celestial Mechanics provides a comprehensive background of celestial mechanics for practical applications. Celestial mechanics is the branch of astronomy that is devoted to the motions of celestial bodies. This book is composed of 17 chapters, and begins with the concept of elliptic motion and its expansion. The subsequent chapters are devoted to other aspects of celestial mechanics, including gravity, numerical integration of orbit, stellar aberration, lunar theory, and celestial coordinates. Considerable chapters explore the principles and application of various mathematical metho

  1. ARK methods: some recent developments

    Science.gov (United States)

    Moir, Nicolette

    2005-03-01

    Almost Runge-Kutta methods are a sub-class of the family of methods known as general linear methods, used for solving ordinary differential equations. They combine many of the favourable properties of traditional Runge-Kutta methods with some additional advantages. We will introduce these methods, concentrating on methods of order four, and present some recent results.

  2. Multigrid methods III

    CERN Document Server

    Trottenberg, U; Third European Conference on Multigrid Methods

    1991-01-01

    These proceedings contain a selection of papers presented at the Third European Conference on Multigrid Methods which was held in Bonn on October 1-4, 1990. Following conferences in 1981 and 1985, a platform for the presentation of new Multigrid results was provided for a third time. Multigrid methods no longer have problems being accepted by numerical analysts and users of numerical methods; on the contrary, they have been further developed in such a successful way that they have penetrated a variety of new fields of application. The high number of 154 participants from 18 countries and 76 presented papers show the need to continue the series of the European Multigrid Conferences. The papers of this volume give a survey on the current Multigrid situation; in particular, they correspond to those fields where new developments can be observed. For example, se­ veral papers study the appropriate treatment of time dependent problems. Improvements can also be noticed in the Multigrid approach for semiconductor eq...

  3. Stochastic Methods in Biology

    CERN Document Server

    Kallianpur, Gopinath; Hida, Takeyuki

    1987-01-01

    The use of probabilistic methods in the biological sciences has been so well established by now that mathematical biology is regarded by many as a distinct dis­ cipline with its own repertoire of techniques. The purpose of the Workshop on sto­ chastic methods in biology held at Nagoya University during the week of July 8-12, 1985, was to enable biologists and probabilists from Japan and the U. S. to discuss the latest developments in their respective fields and to exchange ideas on the ap­ plicability of the more recent developments in stochastic process theory to problems in biology. Eighteen papers were presented at the Workshop and have been grouped under the following headings: I. Population genetics (five papers) II. Measure valued diffusion processes related to population genetics (three papers) III. Neurophysiology (two papers) IV. Fluctuation in living cells (two papers) V. Mathematical methods related to other problems in biology, epidemiology, population dynamics, etc. (six papers) An important f...

  4. Validation of analytical methods

    Directory of Open Access Journals (Sweden)

    Xavier Rius, F.

    2002-03-01

    Full Text Available In this paper we shall discuss the concept of method validation, describe the various elements and explain its close relationship with fitness for purpose. Method validation is based on the assumption that a series of requirements are fulfilled and we shall explain how these requirements are selected, the way in which evidence is supplied and what work has to be carried out in the laboratory. The basic principles of method validation and the different ways to validate a methodology, by inter-laboratory comparison or performing an in-house validation, are also described.En este artículo se discute el concepto de validación del método, se describen los elementos que la componen y se explica la fuerte relación entre la validación y las características de ajuste. El método de validación se basa en el cumplimiento de una serie de requerimientos, se explica como seleccionar esos requerimientos, la forma en que se suministran evidencias, y que trabajo se debe llevar a cabo en el laboratorio. También se describen, los principios básicos del método de validación y los diferentes caminos para validar una metodología, tanto en la comparación entre laboratorios o como cuando se lleva a cabo una validación dentro del laboratorio.

  5. Generalized Agile Estimation Method

    Directory of Open Access Journals (Sweden)

    Shilpa Bahlerao

    2011-01-01

    Full Text Available Agile cost estimation process always possesses research prospects due to lack of algorithmic approaches for estimating cost, size and duration. Existing algorithmic approach i.e. Constructive Agile Estimation Algorithm (CAEA is an iterative estimation method that incorporates various vital factors affecting the estimates of the project. This method has lots of advantages but at the same time has some limitations also. These limitations may due to some factors such as number of vital factors and uncertainty involved in agile projects etc. However, a generalized agile estimation may generate realistic estimates and eliminates the need of experts. In this paper, we have proposed iterative Generalized Estimation Method (GEM and presented algorithm based on it for agile with case studies. GEM  based algorithm various project domain classes and vital factors with prioritization level. Further, it incorporates uncertainty factor to quantify the risk of project for estimating cost, size and duration. It also provides flexibility to project managers for deciding on number of vital factors, uncertainty level and project domains thereby maintaining the agility.

  6. Method Engineering: Engineering of Information Systems Development Methods and Tools

    NARCIS (Netherlands)

    Brinkkemper, J.N.; Brinkkemper, Sjaak

    1996-01-01

    This paper proposes the term method engineering for the research field of the construction of information systems development methods and tools. Some research issues in method engineering are identified. One major research topic in method engineering is discussed in depth: situational methods, i.e.

  7. The data embedding method

    Energy Technology Data Exchange (ETDEWEB)

    Sandford, M.T. II; Bradley, J.N.; Handel, T.G.

    1996-06-01

    Data embedding is a new steganographic method for combining digital information sets. This paper describes the data embedding method and gives examples of its application using software written in the C-programming language. Sandford and Handel produced a computer program (BMPEMBED, Ver. 1.51 written for IBM PC/AT or compatible, MS/DOS Ver. 3.3 or later) that implements data embedding in an application for digital imagery. Information is embedded into, and extracted from, Truecolor or color-pallet images in Microsoft{reg_sign} bitmap (.BMP) format. Hiding data in the noise component of a host, by means of an algorithm that modifies or replaces the noise bits, is termed {open_quote}steganography.{close_quote} Data embedding differs markedly from conventional steganography, because it uses the noise component of the host to insert information with few or no modifications to the host data values or their statistical properties. Consequently, the entropy of the host data is affected little by using data embedding to add information. The data embedding method applies to host data compressed with transform, or {open_quote}lossy{close_quote} compression algorithms, as for example ones based on discrete cosine transform and wavelet functions. Analysis of the host noise generates a key required for embedding and extracting the auxiliary data from the combined data. The key is stored easily in the combined data. Images without the key cannot be processed to extract the embedded information. To provide security for the embedded data, one can remove the key from the combined data and manage it separately. The image key can be encrypted and stored in the combined data or transmitted separately as a ciphertext much smaller in size than the embedded data. The key size is typically ten to one-hundred bytes, and it is in data an analysis algorithm.

  8. Data embedding method

    Science.gov (United States)

    Sandford, Maxwell T., II; Bradley, Jonathan N.; Handel, Theodore G.

    1996-01-01

    Data embedding is a new steganographic method for combining digital information sets. This paper describes the data embedding method and gives examples of its application using software written in the C-programming language. Sandford and Handel produced a computer program (BMPEMBED, Ver. 1.51 written for IBM PC/AT or compatible, MS/DOS Ver. 3.3 or later) that implements data embedding in an application for digital imagery. Information is embedded into, and extracted from, Truecolor or color-pallet images in MicrosoftTM bitmap (BMP) format. Hiding data in the noise component of a host, by means of an algorithm that modifies or replaces the noise bits, is termed `steganography.' Data embedding differs markedly from conventional steganography, because it uses the noise component of the host to insert information with few or no modifications to the host data values or their statistical properties. Consequently, the entropy of the host data is affected little by using data embedding to add information. The data embedding method applies to host data compressed with transform, or `lossy' compression algorithms, as for example ones based on discrete cosine transform and wavelet functions. Analysis of the host noise generates a key required for embedding and extracting the auxiliary data from the combined data. The key is stored easily in the combined data. Images without the key cannot be processed to extract the embedded information. To provide security for the embedded data, one can remove the key from the combined data and manage it separately. The image key can be encrypted and stored in the combined data or transmitted separately as a ciphertext much smaller in size than the embedded data. The key size is typically ten to one-hundred bytes, and it is derived from the original host data by an analysis algorithm.

  9. ZIRCONIUM PHOSPHATE ADSORPTION METHOD

    Science.gov (United States)

    Russell, E.R.; Adamson, A.S.; Schubert, J.; Boyd, G.E.

    1958-11-01

    A method is presented for separating plutonium values from fission product values in aqueous acidic solution. This is accomplished by flowing the solutlon containing such values through a bed of zirconium orthophosphate. Any fission products adsorbed can subsequently be eluted by washing the column with a solution of 2N HNO/sub 3/ and O.lN H/sub 3/PO/sub 4/. Plutonium values may subsequently be desorbed by contacting the column with a solution of 7N HNO/sub 3/ .

  10. Methods of graded rings

    CERN Document Server

    Nastasescu, Constantin

    2004-01-01

    The topic of this book, graded algebra, has developed in the past decade to a vast subject with new applications in noncommutative geometry and physics. Classical aspects relating to group actions and gradings have been complemented by new insights stemming from Hopf algebra theory. Old and new methods are presented in full detail and in a self-contained way. Graduate students as well as researchers in algebra, geometry, will find in this book a useful toolbox. Exercises, with hints for solution, provide a direct link to recent research publications. The book is suitable for courses on Master level or textbook for seminars.

  11. Control system design method

    Science.gov (United States)

    Wilson, David G [Tijeras, NM; Robinett, III, Rush D.

    2012-02-21

    A control system design method and concomitant control system comprising representing a physical apparatus to be controlled as a Hamiltonian system, determining elements of the Hamiltonian system representation which are power generators, power dissipators, and power storage devices, analyzing stability and performance of the Hamiltonian system based on the results of the determining step and determining necessary and sufficient conditions for stability of the Hamiltonian system, creating a stable control system based on the results of the analyzing step, and employing the resulting control system to control the physical apparatus.

  12. Calcium measurement methods

    Directory of Open Access Journals (Sweden)

    CarloAlberto Redi

    2010-09-01

    Full Text Available Rightly stressed by prof. Wolfgang Walz in the Preface to the series Neuromethods series, the “careful application of methods is probably the most important step in the process of scientific inquiry”. Thus, I strongly suggest to all those interested in calcium signaling and especially to the new-comers in the hot topic of neuroscience (which has so much space even in science-society debate for its implications in legal issues and in the judge-decision process to take profit from this so well edited book. I am saying this since prof. Verkhratsky and prof. Petersen......

  13. Methods of thermodynamics

    CERN Document Server

    Reiss, Howard

    1997-01-01

    Since there is no shortage of excellent general books on elementary thermodynamics, this book takes a different approach, focusing attention on the problem areas of understanding of concept and especially on the overwhelming but usually hidden role of ""constraints"" in thermodynamics, as well as on the lucid exposition of the significance, construction, and use (in the case of arbitrary systems) of the thermodynamic potential. It will be especially useful as an auxiliary text to be used along with any standard treatment.Unlike some texts, Methods of Thermodynamics does not use statistical m

  14. Geometrical method of decoupling

    Directory of Open Access Journals (Sweden)

    C. Baumgarten

    2012-12-01

    Full Text Available The computation of tunes and matched beam distributions are essential steps in the analysis of circular accelerators. If certain symmetries—like midplane symmetry—are present, then it is possible to treat the betatron motion in the horizontal, the vertical plane, and (under certain circumstances the longitudinal motion separately using the well-known Courant-Snyder theory, or to apply transformations that have been described previously as, for instance, the method of Teng and Edwards. In a preceding paper, it has been shown that this method requires a modification for the treatment of isochronous cyclotrons with non-negligible space charge forces. Unfortunately, the modification was numerically not as stable as desired and it was still unclear, if the extension would work for all conceivable cases. Hence, a systematic derivation of a more general treatment seemed advisable. In a second paper, the author suggested the use of real Dirac matrices as basic tools for coupled linear optics and gave a straightforward recipe to decouple positive definite Hamiltonians with imaginary eigenvalues. In this article this method is generalized and simplified in order to formulate a straightforward method to decouple Hamiltonian matrices with eigenvalues on the real and the imaginary axis. The decoupling of symplectic matrices which are exponentials of such Hamiltonian matrices can be deduced from this in a few steps. It is shown that this algebraic decoupling is closely related to a geometric “decoupling” by the orthogonalization of the vectors E[over →], B[over →], and P[over →], which were introduced with the so-called “electromechanical equivalence.” A mathematical analysis of the problem can be traced down to the task of finding a structure-preserving block diagonalization of symplectic or Hamiltonian matrices. Structure preservation means in this context that the (sequence of transformations must be symplectic and hence canonical. When

  15. Method of joining ceramics

    Science.gov (United States)

    Henager, Jr., Charles H.; Brimhall, John L.

    2000-01-01

    According to the method of the present invention, joining a first bi-element carbide to a second bi-element carbide, has the steps of: (a) forming a bond agent containing a metal carbide and silicon; (b) placing the bond agent between the first and second bi-element carbides to form a pre-assembly; and (c) pressing and heating the pre-assembly in a non-oxidizing atmosphere to a temperature effective to induce a displacement reaction creating a metal silicon phase bonding the first and second bi-element carbides.

  16. Object oriented methods

    CERN Document Server

    Graham, Ian

    1994-01-01

    This book is a revision of Ian Graham's successful survey of the whole area of object technology. It covers object- oriented programming, object-oriented design, object- oriented analysis, object-oriented databases and treats several related technologies. New to this edition are more applications of object-oriented methods and more coverage of object-oriented database products available. Graham has also doubled the design and analysis material that examines over 60 different approaches - making this the most comprehensive book on the market. Also new is the foreword by Grady Booch.

  17. Electrical estimating methods

    CERN Document Server

    Del Pico, Wayne J

    2014-01-01

    Simplify the estimating process with the latest data, materials, and practices Electrical Estimating Methods, Fourth Edition is a comprehensive guide to estimating electrical costs, with data provided by leading construction database RS Means. The book covers the materials and processes encountered by the modern contractor, and provides all the information professionals need to make the most precise estimate. The fourth edition has been updated to reflect the changing materials, techniques, and practices in the field, and provides the most recent Means cost data available. The complexity of el

  18. Introduction to Numerical Methods

    Energy Technology Data Exchange (ETDEWEB)

    Schoonover, Joseph A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-14

    These are slides for a lecture for the Parallel Computing Summer Research Internship at the National Security Education Center. This gives an introduction to numerical methods. Repetitive algorithms are used to obtain approximate solutions to mathematical problems, using sorting, searching, root finding, optimization, interpolation, extrapolation, least squares regresion, Eigenvalue problems, ordinary differential equations, and partial differential equations. Many equations are shown. Discretizations allow us to approximate solutions to mathematical models of physical systems using a repetitive algorithm and introduce errors that can lead to numerical instabilities if we are not careful.

  19. Epitope prediction methods

    DEFF Research Database (Denmark)

    Karosiene, Edita

    on machine learning techniques. Several MHC class I binding prediction algorithms have been developed and due to their high accuracy they are used by many immunologists to facilitate the conventional experimental process of epitope discovery. However, the accuracy of these methods depends on data defining...... the NetMHCIIpan-3.0 predictor based on artificial neural networks, which is capable of giving binding affinities to any human MHC class II molecule. Chapter 4 of this thesis gives an overview of bioinformatics tools developed by the Immunological Bioinformatics group at Center for Biological Sequence...

  20. Formal Methods in Industry

    Directory of Open Access Journals (Sweden)

    Alexei Serna A.

    2012-12-01

    Full Text Available The application of formal methods in industry has progressed extensively over the past decade and the results are promising. But despite these achievements and it have been documented in numerous studies, it is still very common the skepticism about its usefulness and applicability. The goal of this paper is to show that its evolution over the past decade exceeds all previous processes and each time they do a better job to satisfy industrial needs. This is achieved by the description of some experiments and the result of various applications in industry and through an analyzing of the needs of companies that must be satisfy the research community in this field.