WorldWideScience

Sample records for rest non-local analysis

  1. Stability of Non-Neutral Plasma Cylinder Consisting of Magnetized Cold Electrons and of Small Density Fraction of Ions Born at Rest: Non-Local Analysis

    International Nuclear Information System (INIS)

    Yeliseyev, Y. N.

    2009-01-01

    The non-local stability problem of the plasma cylinder, filled with 'cold' magnetized rigidly rotating electrons, and a small density fraction of ions, is solved. The ions are supposed to be born at rest by ionization of background gas. The study is based on the kinetic description of ions. The equilibrium distribution function, taking into account the peculiarity of ions birth, is used. The radial electric field is caused by space charge of non-neutral plasma. The dispersion equation for plasma eigen frequencies is obtained analytically. It is valid within the total admissible range of values of electric and magnetic fields. Normalized eigen frequencies ω'/Ω i are calculated for the basic azimuth mode m = 1(ω' ω-mω i + , ω + = (-ω ci +Ω i )/2, Ω i (ω ci 2 -4eE r /m i r) 1/2 is called the 'modified' ion cyclotron (MIC) frequency), for the density fraction of ions of atomic nitrogen f N i /n e = 0,01 and are presented in graphic form versus parameter 2ω pe 2 /ω ce 2 . The spectra of oscillations ω'/Ω i consist of the family of electron Trivel-piece--Gould (TG) modes and of the families of MIC modes. The frequencies of MIC modes are located in a small vicinity of harmonics of the MIC frequency Ω i above and below the harmonic. The TG modes in non-neutral plasma fall in the region of MIC frequencies Ω i and interact strongly with MIC modes. The slow TG modes become unstable near the crossings with non-negative harmonics of MIC frequencies. The instabilities have a resonant character. The lowest radial TG mode has a maximum growth rate at crossing with a zero harmonic of Ω i ((Im ω'/Ω i ) max ≅0,074). The growth rates of MIC modes are much lower ((Im ω'/Ω i ) max pe 2 /ω ce 2 , corresponding to strong radial electric fields (ω ci 2 r /m i r|), in which the ions are unmagnetized. The oscillations of small amplitude are seen on some frequency dependencies of MIC modes. They are similar to oscillations on dispersion curves of electron waves in

  2. Stability of Non-Neutral Plasma Cylinder Consisting of Magnetized Cold Electrons and of Small Density Fraction of Ions Born at Rest: Non-Local Analysis

    Science.gov (United States)

    Yeliseyev, Y. N.

    2009-03-01

    The non-local stability problem of the plasma cylinder, filled with "cold" magnetized rigidly rotating electrons, and a small density fraction of ions, is solved. The ions are supposed to be born at rest by ionization of background gas. The study is based on the kinetic description of ions. The equilibrium distribution function, taking into account the peculiarity of ions birth, is used. The radial electric field is caused by space charge of non-neutral plasma. The dispersion equation for plasma eigen frequencies is obtained analytically. It is valid within the total admissible range of values of electric and magnetic fields. Normalized eigen frequencies ω'/Ωi are calculated for the basic azimuth mode m = 1 (ω' = ω-mωi+, ω+ = (-ωci+Ωi)/2, Ωi = (ωci2-4eEr/mir)1/2 is called the "modified" ion cyclotron (MIC) frequency), for the density fraction of ions of atomic nitrogen f = Ni/ne = 0,01 and are presented in graphic form versus parameter 2ωpe2/ωce2. The spectra of oscillations ω'/Ωi consist of the family of electron Trivel-piece—Gould (TG) modes and of the families of MIC modes. The frequencies of MIC modes are located in a small vicinity of harmonics of the MIC frequency Ωi above and below the harmonic. The TG modes in non-neutral plasma fall in the region of MIC frequencies Ωi and interact strongly with MIC modes. The slow TG modes become unstable near the crossings with non-negative harmonics of MIC frequencies. The instabilities have a resonant character. The lowest radial TG mode has a maximum growth rate at crossing with a zero harmonic of Ωi ((Im ω'/Ωi)max≈0,074). The growth rates of MIC modes are much lower ((Im ω'/Ωi)max≲0,002). Their instability has a threshold character. The instabilities of TG and MIC modes take place mainly at the values of parameter 2ωpe2/ωce2, corresponding to strong radial electric fields (ωci2≪|eEr/mir|), in which the ions are unmagnetized. The oscillations of small amplitude are seen on some frequency

  3. Analysis of Non Local Image Denoising Methods

    Science.gov (United States)

    Pardo, Álvaro

    Image denoising is probably one of the most studied problems in the image processing community. Recently a new paradigm on non local denoising was introduced. The Non Local Means method proposed by Buades, Morel and Coll attracted the attention of other researches who proposed improvements and modifications to their proposal. In this work we analyze those methods trying to understand their properties while connecting them to segmentation based on spectral graph properties. We also propose some improvements to automatically estimate the parameters used on these methods.

  4. Non-local model analysis of heat pulse propagation

    International Nuclear Information System (INIS)

    Iwasaki, Takuya; Itoh, Sanae-I.; Yagi, Masatoshi

    1998-01-01

    A new theoretical model equation which includes the non-local effect in the heat flux is proposed to study the transient transport phenomena. A non-local heat flux, which is expressed in terms of the integral equation, is superimposed on the conventional form of the heat flux. This model is applied to describe the experimental results from the power switching [Stroth U, et al 1996 Plasma Phys. Control. Fusion 38 1087] and the power modulation experiments [Giannone L, et al 1992 Nucl. Fusion 32 1985] in the W7-AS stellarator. A small fraction of non-local component in the heat flux is found to be very effective in modifying the response against an external modulation. The transient feature of the transport property, which are observed in the response of heat pulse propagation, are qualitatively reproduced by the transport simulations based on this model. A possibility is discussed to determine the correlation length of the non-local effect experimentally by use of the results of transport simulations. (author)

  5. A non-local model analysis of heat pulse propagation

    International Nuclear Information System (INIS)

    Iwasaki, T.; Itoh, S.I.; Yagi, M.; Stroth, U.

    1998-01-01

    The anomalous transport in high temperature plasma has been studied for a long time, from the beginning of the fusion research. Since the electron channel in stellarators and tokamaks is clearly anomalous, it is of fundamental importance to investigate the electron heat diffusivity coefficient, χ e and to understand the physical mechanism. Recently, the experimental data for the transient transport of the heat pulse propagation in fusion plasma has been accumulated. An observation was reported on W7-AS which the heat flux changes faster than the change of the temperature profile, responding to the switching on off of the central heating power. The observation on the transient response has simulated the transport modeling, e.g., the critical marginality which implies the existence of a finite threshold in ∇T for the excitation of the turbulence, or the model in which the thermal conductivity is assumed to depend on the heating power. Extensive study is made by use of these models, and the critical marginally model seems to be insufficient to explain various transient transport. The rapid change of the plasma state and its hysteresis nature were successfully modeled by a heating-power-dependent model. The foundation of this model, however, is left for future work. The development of the transport modeling remains to be an urgent problem. In this paper, we investigate the role of the non-locality of the plasma transport in the study of the heat pulse propagation. For this purpose, a model equation is proposed, in which the non-local effect is taken into account in the heat flux. The properties of this model are investigated by performing a transport simulation. The organization of this paper is as follows: In Sec. II, the model equation is proposed and the properties of the model are explained. Using the model equation, the switching on off experiment is simulated in Sec. III. Summary and discussion are given in Sec. IV. (author)

  6. Non--Local Approach to the Analysis of the Stress Distribution in Granular Systems.

    Science.gov (United States)

    Scott, J. E.; Kenkre, V. M.; Hurd, A. J.

    1998-03-01

    A continuum mechanical theory of the stress distribution in granular materials is presented, where the transformation of the vertical spatial coordinate into a formal time variable converts the study of the static stress distribution into a generally non--Markoffian, i.e., memory-possessing (non-local) propagation analysis. Previous treatments (J. -P). Bouchaud, M. E. Cates, and P. Claudin, J. Phys. I France 5, 639 (1995). (C. -h). Liu, S. R. Nagel, D. A. Schecter, S. N. Coppersmith, S. Majumdar, O. Narayan, and T. A. Witten, Science 269, 513 (1995). are shown to be particular cases of our theory corresponding to, respectively, wave-like and dif fusive limits of the general evolution. Calculations are presented for the example of ceramic or metal powder compaction in dies, with emphasis on the understanding of previously unexplained features as seen in experimental data found in the literature o ver the past 50 years. Specific proposals for new experimental investigations are presented.

  7. Analysis of the cable equation with non-local and non-singular kernel fractional derivative

    Science.gov (United States)

    Karaagac, Berat

    2018-02-01

    Recently a new concept of differentiation was introduced in the literature where the kernel was converted from non-local singular to non-local and non-singular. One of the great advantages of this new kernel is its ability to portray fading memory and also well defined memory of the system under investigation. In this paper the cable equation which is used to develop mathematical models of signal decay in submarine or underwater telegraphic cables will be analysed using the Atangana-Baleanu fractional derivative due to the ability of the new fractional derivative to describe non-local fading memory. The existence and uniqueness of the more generalized model is presented in detail via the fixed point theorem. A new numerical scheme is used to solve the new equation. In addition, stability, convergence and numerical simulations are presented.

  8. A NON-LOCAL THERMODYNAMIC EQUILIBRIUM ANALYSIS OF BORON ABUNDANCES IN METAL-POOR STARS

    International Nuclear Information System (INIS)

    Tan Kefeng; Shi Jianrong; Zhao Gang

    2010-01-01

    The non-local thermodynamic equilibrium (NLTE) line formation of neutral boron in the atmospheres of cool stars are investigated. Our results confirm that NLTE effects for the B I resonance lines, which are due to a combination of overionization and optical pumping effects, are most important for hot, metal-poor, and low-gravity stars; however, the amplitude of departures from local thermodynamic equilibrium (LTE) found by this work is smaller than that of previous studies. In addition, our calculation shows that the line formation of B I will get closer to LTE if the strength of collisions with neutral hydrogen increases, which is contrary to the result of previous studies. The NLTE line formation results are applied to the determination of boron abundances for a sample of 16 metal-poor stars with the method of spectrum synthesis of the B I 2497 A resonance lines using the archived HST/GHRS spectra. Beryllium and oxygen abundances are also determined for these stars with the published equivalent widths of the Be II 3131 A resonance and O I 7774 A triplet lines, respectively. The abundances of the nine stars which are not depleted in Be or B show that, no matter what the strength of collisions with neutral hydrogen may be, both Be and B increase with O quasilinearly in the logarithmic plane, which confirms the conclusions that Be and B are mainly produced by the primary process in the early Galaxy. The most noteworthy result of this work is that B increases with Fe or O at a very similar speed as, or a bit faster than, Be does, which is in accord with the theoretical models. The B/Be ratios remain almost constant over the metallicity range investigated here. Our average B/Be ratio falls in the interval [13 ± 4, 17 ± 4], which is consistent with the predictions of the spallation process. The contribution of B from the ν-process may be required if the 11 B/ 10 B isotopic ratios in metal-poor stars are the same as the meteoric value. An accurate measurement of the

  9. Foundations of complex analysis in non locally convex spaces function theory without convexity condition

    CERN Document Server

    Bayoumi, A

    2003-01-01

    All the existing books in Infinite Dimensional Complex Analysis focus on the problems of locally convex spaces. However, the theory without convexity condition is covered for the first time in this book. This shows that we are really working with a new, important and interesting field. Theory of functions and nonlinear analysis problems are widespread in the mathematical modeling of real world systems in a very broad range of applications. During the past three decades many new results from the author have helped to solve multiextreme problems arising from important situations, non-convex and

  10. Non-local model analysis of heat pulse propagation and simulation of experiments in W7-AS

    International Nuclear Information System (INIS)

    Iwasaki, Takuya; Itoh, Sanae-I.; Yagi, Masatoshi; Itoh, Kimitaka; Stroth, U.

    1999-01-01

    A new model equation which includes the non-local effect in the hear flux is introduced to study the transient transport phenomena. A non-local heat flux, which is expressed in terms of the integral equation, is superimposed on the conventional form of the heat flux. This model is applied to describe the experimental results from the power switching [U. Stroth et al.: Plasma Phys. Control. Fusion 38 (1996) 1087] and the power modulation experiments [L. Giannone et al.: Nucl. Fusion 32 (1992) 1985] in the W7-AS stellarator. A small fraction of non-local component in the heat flux is found to be very effective in modifying the response against an external modulation. The transient feature of the transport property, which are observed in the response of heat pulse propagation, are qualitatively reproduced by the transport simulations based on this model. A possibility is discussed to estimate the correlation length of the non-local effect experimentally by use of the results of transport simulations. (author)

  11. Complete mechanical behavior analysis of FG Nano Beam under non-uniform loading using non-local theory

    Science.gov (United States)

    Ghaffari, I.; Parhizkar Yaghoobi, M.; Ghannad, M.

    2018-01-01

    The purpose of this study is to offer a complete solution to analyze the mechanical behavior (bending, buckling and vibration) of Nano-beam under non-uniform loading. Furthermore, the effects of size (nonlocal parameters), non-homogeneity constants, and different boundary conditions are investigated by using this method. The exact solution presented here reduces costs incurred by experiments. In this research, the displacement field obeys the kinematics of the Euler-Bernoulli beam theory and non-local elasticity theory has been used. The governing equations and general boundary conditions are derived for a beam by using energy method. The presented solution enables us to analyze any kind of loading profile and boundary conditions with no limitations. Furthermore, this solution, unlike previous studies, is not a series-solution; hence, there is no limitation prior to existing with the series-solution, nor does it need to check convergence. Based on the developed analytical solution, the influence of size, non-homogeneity and non-uniform loads on bending, buckling and vibration behaviors is discussed. Also, the obtained result is highly accurate and in good agreement with previous research. In theoretical method, the allowable range for non-local parameters can be determined so as to make a major contribution to the reduction of the cost of experiments determining the value of non-local parameters.

  12. Resting state fMRI: A review on methods in resting state connectivity analysis and resting state networks.

    Science.gov (United States)

    Smitha, K A; Akhil Raja, K; Arun, K M; Rajesh, P G; Thomas, Bejoy; Kapilamoorthy, T R; Kesavadas, Chandrasekharan

    2017-08-01

    The inquisitiveness about what happens in the brain has been there since the beginning of humankind. Functional magnetic resonance imaging is a prominent tool which helps in the non-invasive examination, localisation as well as lateralisation of brain functions such as language, memory, etc. In recent years, there is an apparent shift in the focus of neuroscience research to studies dealing with a brain at 'resting state'. Here the spotlight is on the intrinsic activity within the brain, in the absence of any sensory or cognitive stimulus. The analyses of functional brain connectivity in the state of rest have revealed different resting state networks, which depict specific functions and varied spatial topology. However, different statistical methods have been introduced to study resting state functional magnetic resonance imaging connectivity, yet producing consistent results. In this article, we introduce the concept of resting state functional magnetic resonance imaging in detail, then discuss three most widely used methods for analysis, describe a few of the resting state networks featuring the brain regions, associated cognitive functions and clinical applications of resting state functional magnetic resonance imaging. This review aims to highlight the utility and importance of studying resting state functional magnetic resonance imaging connectivity, underlining its complementary nature to the task-based functional magnetic resonance imaging.

  13. Can EPR non-locality be geometrical?

    International Nuclear Information System (INIS)

    Ne'eman, Y.

    1995-01-01

    The presence in Quantum Mechanics of non-local correlations is one of the two fundamentally non-intuitive features of that theory. The non-local correlations themselves fall into two classes: EPR and Geometrical. The non-local characteristics of the geometrical type are well-understood and are not suspected of possibly generating acausal features, such as faster-than-light propagation of information. This has especially become true since the emergence of a geometrical treatment for the relevant gauge theories, i.e. Fiber Bundle geometry, in which the quantum non-localities are seen to correspond to pure homotopy considerations. This aspect is reviewed in section 2. Contrary-wise, from its very conception, the EPR situation was felt to be paradoxical. It has been suggested that the non-local features of EPR might also derive from geometrical considerations, like all other non-local characteristics of QM. In[7], one of the authors was able to point out several plausibility arguments for this thesis, emphasizing in particular similarities between the non-local correlations provided by any gauge field theory and those required by the preservation of the quantum numbers of the original EPR state-vector, throughout its spatially-extended mode. The derivation was, however, somewhat incomplete, especially because of the apparent difference between, on the one hand, the closed spatial loops arising in the analysis of the geometrical non-localities, from Aharonov-Bohm and Berry phases to magnetic monopoles and instantons, and on the other hand, in the EPR case, the open line drawn by the positions of the two moving decay products of the disintegrating particle. In what follows, the authors endeavor to remove this obstacle and show that as in all other QM non-localities, EPR is somehow related to closed loops, almost involving homotopy considerations. They develop this view in section 3

  14. Nonlinear static analysis of single layer annular/circular graphene sheets embedded in Winkler–Pasternak elastic matrix based on non-local theory of Eringen

    Directory of Open Access Journals (Sweden)

    Shahriar Dastjerdi

    2016-06-01

    Full Text Available Nonlinear bending analysis of orthotropic annular/circular graphene sheets has been studied based on the non-local elasticity theory. The first order shear deformation theory (FSDT is applied in combination with the nonlinear Von-Karman strain field. The obtained differential equations are solved by using two methods, first the differential quadrature method (DQM and a new semi-analytical polynomial method (SAPM which is innovated by the authors. Applying the DQM or SAPM, the differential equations are transformed to nonlinear algebraic equations system. Then the Newton–Raphson iterative scheme is used. First, the obtained results from DQM and SAPM are compared and it is concluded that although the SAPM’s formulation is considerably simpler than DQM, however, the SAPM’s results are so close to DQM. The results are validated with available papers. Finally, the effects of small scale parameter on the results, the comparison between local and non-local theories, and linear to nonlinear analyses are investigated.

  15. Non-Local Effects in Kaonic Atoms

    International Nuclear Information System (INIS)

    Lutz, M.; Florkowski, W.

    2000-01-01

    Optical potentials with non-local (gradient) terms are used to describe the spectra of kaonic atoms. The strength of the non-local terms is determined from a many-body calculation of the kaon self energy in nuclear matter. We find that the non-local terms are quantitatively important and the results depend strongly on the way the gradient terms are arranged. Phenomenologically successful description is obtained for p-wave like optical potentials. It is suggested that the microscopic form of the non-local interaction terms is obtained systematically by means of a semi-classical expansion of the nucleus structure. (author)

  16. Non-local effects in kaonic atoms

    International Nuclear Information System (INIS)

    Lutz, M.; Florkowski, W.

    2000-04-01

    Optical potentials with non-local (gradient) terms are used to describe the spectra of kaonic atoms. The strength of the non-local terms is determined from a many-body calculation of the kaon self-energy in nuclear matter. The optical potentials show strong non-linearities in the nucleon density and sizeable non-local terms. We find that the non-local terms are quantitatively important and the results depend strongly on the way the gradient terms are arranged. Phenomenologically successful fits are obtained for p-wave like optical potentials. It is suggested that the microscopic form of the non-local interaction terms is obtained systematically by means of a semi-classical expansion of the nucleus structure. We conclude that a microscopic description of kaonic atom data requires further detailed studies of the microscopic K - nuclear dynamics. (orig.)

  17. Macroscopic quantum waves in non local theories

    International Nuclear Information System (INIS)

    Ventura, I.

    1979-01-01

    By means of an expansion in the density, it is shown that Macroscopic Quantum Waves also apear in non local theories. This result reinforces the conjecture that these waves should exist in liquid 4 He. (Author) [pt

  18. Macroscopic quantum waves in non local theories

    International Nuclear Information System (INIS)

    Ventura, I.

    1979-01-01

    By means of an expansion in the density, it is shown that Macroscopic Quantum Waves also appear in non local theories. This result reinforces the conjecture that these waves should exist in liquid 4 He [pt

  19. Employee Travel Data (Non-Local)

    Data.gov (United States)

    Montgomery County of Maryland — ‘This dataset provides information regarding the total approved actual expenses incurred by Montgomery County government employees traveling non-locally (over 75...

  20. Non-local charges in local quantum field theory

    International Nuclear Information System (INIS)

    Buchholz, D.; Lopuszanski, J.T.; Rabsztyn, S.

    1985-05-01

    Non-local charges are studied in the general setting of local quantum field theory. It is shown, that these charges can be represented as polynomials in the incoming respectively outgoing fields with coefficients (kernels) which are subject to specific constraints. For the restricted class of models of a scalar, massive, self interacting particle in four dimensions, a more detailed analysis shows that all non-local charges of the generic type (genus 2) are products of generators of the Poincare group. This analysis, which is based on the macroscopic causality properties of the S-matrix, seems to indicate that less trivial examples of non-local charges can only exist in two dimensions. (orig.)

  1. Guided SAR image despeckling with probabilistic non local weights

    Science.gov (United States)

    Gokul, Jithin; Nair, Madhu S.; Rajan, Jeny

    2017-12-01

    SAR images are generally corrupted by granular disturbances called speckle, which makes visual analysis and detail extraction a difficult task. Non Local despeckling techniques with probabilistic similarity has been a recent trend in SAR despeckling. To achieve effective speckle suppression without compromising detail preservation, we propose an improvement for the existing Generalized Guided Filter with Bayesian Non-Local Means (GGF-BNLM) method. The proposed method (Guided SAR Image Despeckling with Probabilistic Non Local Weights) replaces parametric constants based on heuristics in GGF-BNLM method with dynamically derived values based on the image statistics for weight computation. Proposed changes make GGF-BNLM method adaptive and as a result, significant improvement is achieved in terms of performance. Experimental analysis on SAR images shows excellent speckle reduction without compromising feature preservation when compared to GGF-BNLM method. Results are also compared with other state-of-the-art and classic SAR depseckling techniques to demonstrate the effectiveness of the proposed method.

  2. Gauging Non-local Quark Models

    International Nuclear Information System (INIS)

    Broniowski, W.

    1999-09-01

    The gauge effective quark model with non-local interactions is considered. It is shown how this approach regularize the theory in such a way that the anomalies are preserved and charges are properly quantized. With non-local interactions the effective action is finite to all orders in the loop expansion and there is no need to introduce the quark momentum cut-off parameter

  3. Robust non-local median filter

    Science.gov (United States)

    Matsuoka, Jyohei; Koga, Takanori; Suetake, Noriaki; Uchino, Eiji

    2017-04-01

    This paper describes a novel image filter with superior performance on detail-preserving removal of random-valued impulse noise superimposed on natural gray-scale images. The non-local means filter is in the limelight as a way of Gaussian noise removal with superior performance on detail preservation. By referring the fundamental concept of the non-local means, we had proposed a non-local median filter as a specialized way for random-valued impulse noise removal so far. In the non-local processing, the output of a filter is calculated from pixels in blocks which are similar to the block centered at a pixel of interest. As a result, aggressive noise removal is conducted without destroying the detailed structures in an original image. However, the performance of non-local processing decreases enormously in the case of high noise occurrence probability. A cause of this problem is that the superimposed noise disturbs accurate calculation of the similarity between the blocks. To cope with this problem, we propose an improved non-local median filter which is robust to the high level of corruption by introducing a new similarity measure considering possibility of being the original signal. The effectiveness and validity of the proposed method are verified in a series of experiments using natural gray-scale images.

  4. Diagnosis of exercise-induced left bundle branch block at rest by scintigraphic phase analysis

    International Nuclear Information System (INIS)

    Schultz, D.A.; Wahl, R.L.; Juni, J.E.; Buda, A.J.; McMeekin, J.D.; Struble, L.R.; Tuscan, M.J.

    1986-01-01

    Accurate diagnosis of disease of the ventricular conducting system is essential for their appropriate therapy. Some conduction abnormalities, such as exercise-induced left bundle branch block (EX-LBBB), are not apparent on resting electrocardiograms. Phase analysis of rest and exercise radionuclide ventriculograms (RVG's) was used to compare four EX-LBBB patients with six normal controls. All patients had normal resting electrocardiograms, ejection fractions, and visually normal wall motion. First harmonic phase images were generated reflecting the timing of ventricular contraction. Dynamic phase displays were reviewed and graded in a blinded fashion by three independent experienced observers. Phase angle histograms of the right and left ventricle were determined for both resting and exercise images. The mean phase angle and standard deviation were also calculated for each ventricle. Visual grading of the resting phase images failed to show a significant difference between normal patients and patients with EX-LBBB. Quantitative analysis, however, revealed a significant difference in mean phase angle differences (LV-RV) in resting studies: 0.8 0 (+-1.9 0 SEM) in normal versus 9.3 0 (+-2.3 0 SEM) in EX-LBBB patients (P 0 in normals vs. 31.2 0 in EX-LBBB patients (P<0.001). Qualitative phase analysis of resting RVG's permits the diagnosis of cardiac conduction disease that is not apparent on the resting EKG and may result in better monitoring and treatment. (orig.)

  5. Rest and the associated benefits in restorative sleep: a concept analysis.

    Science.gov (United States)

    Helvig, Ashley; Wade, Sonya; Hunter-Eades, Lee

    2016-01-01

    To report an analysis of the concept of rest. Consistency in the literature to describe the concept and use of rest is limited. Concept analysis may be advantageous in rendering an operational definition in the health care setting. This analysis is important to examine the concept of rest for structure and function to promote an understanding of the phenomenon. Rest is a vital component of restorative sleep which has implications for physical, mental and spiritual well-being. Concept analysis. A literature search was conducted in the following databases: PubMed, CINAHL, Medline, ProQuest and an online Internet search with the majority of articles published between 1995-2015. This concept analysis was implemented using the eight step approach developed by Walker and Avant. In health care, rest incorporates the cessation of activity used to promote physical and mental health. Defining attributes of rest include a pathway to calm, inner tranquillity and mental health; base of support; and stillness. Antecedents for rest are time, suitable environment and willingness. Resulting consequences include renewed physical energy, mental clarity and improved health. Rest is a concept that is used frequently in the discipline of nursing but also in various other disciplines. Rest is a basic necessity for restorative sleep to enhance well-being through the restoration of the body, mind and spirit. Defining the concept of rest in the practice of patient care is necessary for consistent use of the term in the development of holistic, patient-centred therapies. © 2015 John Wiley & Sons Ltd.

  6. Influence of ROI selection on Resting Functional Connectivity: An Individualized Approach for Resting fMRI Analysis

    Directory of Open Access Journals (Sweden)

    William Seunghyun Sohn

    2015-08-01

    Full Text Available The differences in how our brain is connected are often thought to reflect the differences in our individual personalities and cognitive abilities. Individual differences in brain connectivity has long been recognized in the neuroscience community however it has yet to manifest itself in the methodology of resting state analysis. This is evident as previous studies use the same region of interest (ROIs for all subjects. In this paper we demonstrate that the use of ROIs which are standardized across individuals leads to inaccurate calculations of functional connectivity. We also show that this problem can be addressed by taking an individualized approach by using subject-specific ROIs. Finally we show that ROI selection can affect the way we interpret our data by showing different changes in functional connectivity with ageing.

  7. Graph theoretical analysis of resting magnetoencephalographic functional connectivity networks

    Directory of Open Access Journals (Sweden)

    Lindsay eRutter

    2013-07-01

    Full Text Available Complex networks have been observed to comprise small-world properties, believed to represent an optimal organization of local specialization and global integration of information processing at reduced wiring cost. Here, we applied magnitude squared coherence to resting magnetoencephalographic time series in reconstructed source space, acquired from controls and patients with schizophrenia, and generated frequency-dependent adjacency matrices modeling functional connectivity between virtual channels. After configuring undirected binary and weighted graphs, we found that all human networks demonstrated highly localized clustering and short characteristic path lengths. The most conservatively thresholded networks showed efficient wiring, with topographical distance between connected vertices amounting to one-third as observed in surrogate randomized topologies. Nodal degrees of the human networks conformed to a heavy-tailed exponentially truncated power-law, compatible with the existence of hubs, which included theta and alpha bilateral cerebellar tonsil, beta and gamma bilateral posterior cingulate, and bilateral thalamus across all frequencies. We conclude that all networks showed small-worldness, minimal physical connection distance, and skewed degree distributions characteristic of physically-embedded networks, and that these calculations derived from graph theoretical mathematics did not quantifiably distinguish between subject populations, independent of bandwidth. However, post-hoc measurements of edge computations at the scale of the individual vertex revealed trends of reduced gamma connectivity across the posterior medial parietal cortex in patients, an observation consistent with our prior resting activation study that found significant reduction of synthetic aperture magnetometry gamma power across similar regions. The basis of these small differences remains unclear.

  8. Switching non-local vector median filter

    Science.gov (United States)

    Matsuoka, Jyohei; Koga, Takanori; Suetake, Noriaki; Uchino, Eiji

    2016-04-01

    This paper describes a novel image filtering method that removes random-valued impulse noise superimposed on a natural color image. In impulse noise removal, it is essential to employ a switching-type filtering method, as used in the well-known switching median filter, to preserve the detail of an original image with good quality. In color image filtering, it is generally preferable to deal with the red (R), green (G), and blue (B) components of each pixel of a color image as elements of a vectorized signal, as in the well-known vector median filter, rather than as component-wise signals to prevent a color shift after filtering. By taking these fundamentals into consideration, we propose a switching-type vector median filter with non-local processing that mainly consists of a noise detector and a noise removal filter. Concretely, we propose a noise detector that proactively detects noise-corrupted pixels by focusing attention on the isolation tendencies of pixels of interest not in an input image but in difference images between RGB components. Furthermore, as the noise removal filter, we propose an extended version of the non-local median filter, we proposed previously for grayscale image processing, named the non-local vector median filter, which is designed for color image processing. The proposed method realizes a superior balance between the preservation of detail and impulse noise removal by proactive noise detection and non-local switching vector median filtering, respectively. The effectiveness and validity of the proposed method are verified in a series of experiments using natural color images.

  9. Stability issues of black hole in non-local gravity

    Science.gov (United States)

    Myung, Yun Soo; Park, Young-Jai

    2018-04-01

    We discuss stability issues of Schwarzschild black hole in non-local gravity. It is shown that the stability analysis of black hole for the unitary and renormalizable non-local gravity with γ2 = - 2γ0 cannot be performed in the Lichnerowicz operator approach. On the other hand, for the unitary and non-renormalizable case with γ2 = 0, the black hole is stable against the metric perturbations. For non-unitary and renormalizable local gravity with γ2 = - 2γ0 = const (fourth-order gravity), the small black holes are unstable against the metric perturbations. This implies that what makes the problem difficult in stability analysis of black hole is the simultaneous requirement of unitarity and renormalizability around the Minkowski spacetime.

  10. Non-local modeling of materials

    DEFF Research Database (Denmark)

    Niordson, Christian Frithiof

    2002-01-01

    Numerical studies of non-local plasticity effects on different materials and problems are carried out. Two different theories are used. One is of lower order in that it retains the structure of a conventional plasticity boundary value problem, while the other is of higher order and employs higher...... order stresses as work conjugates to higher order strains and uses higher order boundary conditions. The influence of internal material length parameters is studied, and the effects of higher order boundary conditions are analyzed. The focus of the thesis is on metal-matrix composites, and non...

  11. Complex network analysis of resting-state fMRI of the brain.

    Science.gov (United States)

    Anwar, Abdul Rauf; Hashmy, Muhammad Yousaf; Imran, Bilal; Riaz, Muhammad Hussnain; Mehdi, Sabtain Muhammad Muntazir; Muthalib, Makii; Perrey, Stephane; Deuschl, Gunther; Groppa, Sergiu; Muthuraman, Muthuraman

    2016-08-01

    Due to the fact that the brain activity hardly ever diminishes in healthy individuals, analysis of resting state functionality of the brain seems pertinent. Various resting state networks are active inside the idle brain at any time. Based on various neuro-imaging studies, it is understood that various structurally distant regions of the brain could be functionally connected. Regions of the brain, that are functionally connected, during rest constitutes to the resting state network. In the present study, we employed the complex network measures to estimate the presence of community structures within a network. Such estimate is named as modularity. Instead of using a traditional correlation matrix, we used a coherence matrix taken from the causality measure between different nodes. Our results show that in prolonged resting state the modularity starts to decrease. This decrease was observed in all the resting state networks and on both sides of the brain. Our study highlights the usage of coherence matrix instead of correlation matrix for complex network analysis.

  12. Switching non-local median filter

    Science.gov (United States)

    Matsuoka, Jyohei; Koga, Takanori; Suetake, Noriaki; Uchino, Eiji

    2015-06-01

    This paper describes a novel image filtering method for removal of random-valued impulse noise superimposed on grayscale images. Generally, it is well known that switching-type median filters are effective for impulse noise removal. In this paper, we propose a more sophisticated switching-type impulse noise removal method in terms of detail-preserving performance. Specifically, the noise detector of the proposed method finds out noise-corrupted pixels by focusing attention on the difference between the value of a pixel of interest (POI) and the median of its neighboring pixel values, and on the POI's isolation tendency from the surrounding pixels. Furthermore, the removal of the detected noise is performed by the newly proposed median filter based on non-local processing, which has superior detail-preservation capability compared to the conventional median filter. The effectiveness and the validity of the proposed method are verified by some experiments using natural grayscale images.

  13. Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis.

    Science.gov (United States)

    Lau, W K W; Leung, M-K; Lee, T M C; Law, A C K

    2016-04-26

    Amnestic mild cognitive impairment (aMCI) is a prodromal stage of Alzheimer's disease (AD). As no effective drug can cure AD, early diagnosis and intervention for aMCI are urgently needed. The standard diagnostic procedure for aMCI primarily relies on subjective neuropsychological examinations that require the judgment of experienced clinicians. The development of other objective and reliable aMCI markers, such as neural markers, is therefore required. Previous neuroimaging findings revealed various abnormalities in resting-state activity in MCI patients, but the findings have been inconsistent. The current study provides an updated activation likelihood estimation meta-analysis of resting-state functional magnetic resonance imaging (fMRI) data on aMCI. The authors searched on the MEDLINE/PubMed databases for whole-brain resting-state fMRI studies on aMCI published until March 2015. We included 21 whole-brain resting-state fMRI studies that reported a total of 156 distinct foci. Significant regional resting-state differences were consistently found in aMCI patients relative to controls, including the posterior cingulate cortex, right angular gyrus, right parahippocampal gyrus, left fusiform gyrus, left supramarginal gyrus and bilateral middle temporal gyri. Our findings support that abnormalities in resting-state activities of these regions may serve as neuroimaging markers for aMCI.

  14. Constraining generalized non-local cosmology from Noether symmetries.

    Science.gov (United States)

    Bahamonde, Sebastian; Capozziello, Salvatore; Dialektopoulos, Konstantinos F

    2017-01-01

    We study a generalized non-local theory of gravity which, in specific limits, can become either the curvature non-local or teleparallel non-local theory. Using the Noether symmetry approach, we find that the coupling functions coming from the non-local terms are constrained to be either exponential or linear in form. It is well known that in some non-local theories, a certain kind of exponential non-local couplings is needed in order to achieve a renormalizable theory. In this paper, we explicitly show that this kind of coupling does not need to be introduced by hand, instead, it appears naturally from the symmetries of the Lagrangian in flat Friedmann-Robertson-Walker cosmology. Finally, we find de Sitter and power-law cosmological solutions for different non-local theories. The symmetries for the generalized non-local theory are also found and some cosmological solutions are also achieved using the full theory.

  15. Constraining generalized non-local cosmology from Noether symmetries

    Energy Technology Data Exchange (ETDEWEB)

    Bahamonde, Sebastian [University College London, Department of Mathematics, London (United Kingdom); Capozziello, Salvatore [Universita di Napoli ' ' Federico II' ' , Dipartimento di Fisica ' ' E. Pancini' ' , Naples (Italy); Gran Sasso Science Institute, L' Aquila (Italy); Complesso di Monte Sant' Angelo, Naples (Italy); INFN Sezione di Napoli, Naples (Italy); Dialektopoulos, Konstantinos F. [Universita di Napoli ' ' Federico II' ' , Dipartimento di Fisica ' ' E. Pancini' ' , Naples (Italy); Complesso di Monte Sant' Angelo, Naples (Italy); INFN Sezione di Napoli, Naples (Italy)

    2017-11-15

    We study a generalized non-local theory of gravity which, in specific limits, can become either the curvature non-local or teleparallel non-local theory. Using the Noether symmetry approach, we find that the coupling functions coming from the non-local terms are constrained to be either exponential or linear in form. It is well known that in some non-local theories, a certain kind of exponential non-local couplings is needed in order to achieve a renormalizable theory. In this paper, we explicitly show that this kind of coupling does not need to be introduced by hand, instead, it appears naturally from the symmetries of the Lagrangian in flat Friedmann-Robertson-Walker cosmology. Finally, we find de Sitter and power-law cosmological solutions for different non-local theories. The symmetries for the generalized non-local theory are also found and some cosmological solutions are also achieved using the full theory. (orig.)

  16. Qualitative Resting Coronary Pressure Wave Form Analysis to Predict Fractional Flow Reserve.

    Science.gov (United States)

    Matsumura, Mitsuaki; Maehara, Akiko; Johnson, Nils P; Fearon, William F; De Bruyne, Bernard; Oldroyd, Keith G; Pijls, Nico H J; Jenkins, Paul; Ali, Ziad A; Mintz, Gary S; Stone, Gregg W; Jeremias, Allen

    2018-03-27

    To evaluate the predictability of resting distal coronary pressure wave forms for fractional flow reserve (FFR). Resting coronary wave forms were qualitatively evaluated for the presence of (i) dicrotic notch; (ii) diastolic dipping; and (iii) ventricularization. In a development cohort (n=88) a scoring system was developed that was then applied to a validation cohort (n=428) using a multivariable linear regression model to predict FFR and receiver operating characteristics (ROC) to predict FFR ≤0.8. In the development cohort, all 3 qualitative parameters were independent predictors of FFR. However, in a multivariable linear regression model in the validation cohort, qualitative wave form analysis did not further improve the ability of resting distal coronary to aortic pressure ratio (Pd/Pa) (p=0.80) or instantaneous wave-free ratio (iFR) (p=0.26) to predict FFR. Using ROC, the area under the curve of resting Pd/Pa (0.86 versus 0.86, P=0.08) and iFR (0.86 versus 0.86, P=0.26) did not improve by adding qualitative analysis. Qualitative coronary wave form analysis showed moderate classification agreement in predicting FFR but did not add substantially to the resting pressure gradients Pd/Pa and iFR; however, when discrepancies between quantitative and qualitative analyses are observed, artifact or pressure drift should be considered.

  17. Cross coherence independent component analysis in resting and action states EEG discrimination

    International Nuclear Information System (INIS)

    Almurshedi, A; Ismail, A K

    2014-01-01

    Cross Coherence time frequency transform and independent component analysis (ICA) method were used to analyse the electroencephalogram (EEG) signals in resting and action states during open and close eyes conditions. From the topographical scalp distributions of delta, theta, alpha, and beta power spectrum can clearly discriminate between the signal when the eyes were open or closed, but it was difficult to distinguish between resting and action states when the eyes were closed. In open eyes condition, the frontal area (Fp1, Fp2) was activated (higher power) in delta and theta bands whilst occipital (O1, O2) and partial (P3, P4, Pz) area of brain was activated alpha band in closed eyes condition. The cross coherence method of time frequency analysis is capable of discrimination between rest and action brain signals in closed eyes condition

  18. Characterizing functional connectivity during rest in multiple sclerosis patients versus healthy volunteers using independent component analysis

    Energy Technology Data Exchange (ETDEWEB)

    Palacio Garcia, L.; Andrzejak, R.; Prchkovska, V.; Rodrigues, P.

    2016-07-01

    It is commonly thought that our brain is not active when it does not receive any external input. However, during rest, there are still certain distant regions of the brain that are functionally correlated between them: the so-called resting-state networks. This functional connectivity of the brain is disrupted in many neurological diseases. In particular, it has been shown that one of the most studied resting-state networks (the default-mode network) is affected in multiple sclerosis, which is the most common disabling neurological condition affecting the central nervous system of young adults. In this work, I focus on the study of the differences in the resting-state networks between multiple sclerosis patients and healthy volunteers. In order to study the effects of multiple sclerosis on the functional connectivity of the brain, a numerical method known as independent component analysis (ICA) is applied. This technique divides the resting-state fMRI data into independent components. Nonetheless, noise, which could be due to head motion or physiological artifacts, may corrupt the data by indicating a false activation. Therefore, I create a web user interface that allows the user to manually classify all the independent components for a given subject. Eventually, the components classified as noise should be removed from the functional data in order to prevent them from taking part in any further analysis. (Author)

  19. Functional connectivity analysis of the brain network using resting-state fMRI

    International Nuclear Information System (INIS)

    Hayashi, Toshihiro

    2011-01-01

    Spatial patterns of spontaneous fluctuations in blood oxygenation level-dependent (BOLD) signals reflect the underlying neural architecture. The study of the brain network based on these self-organized patterns is termed resting-state functional MRI (fMRI). This review article aims at briefly reviewing a basic concept of this technology and discussing its implications for neuropsychological studies. First, the technical aspects of resting-state fMRI, including signal sources, physiological artifacts, image acquisition, and analytical methods such as seed-based correlation analysis and independent component analysis, are explained, followed by a discussion on the major resting-state networks, including the default mode network. In addition, the structure-function correlation studied using diffuse tensor imaging and resting-state fMRI is briefly discussed. Second, I have discussed the reservations and potential pitfalls of 2 major imaging methods: voxel-based lesion-symptom mapping and task fMRI. Problems encountered with voxel-based lesion-symptom mapping can be overcome by using resting-state fMRI and evaluating undamaged brain networks in patients. Regarding task fMRI in patients, I have also emphasized the importance of evaluating the baseline brain activity because the amplitude of activation in BOLD fMRI is hard to interpret as the same baseline cannot be assumed for both patient and normal groups. (author)

  20. Android application and REST server system for quasar spectrum presentation and analysis

    Science.gov (United States)

    Wasiewicz, P.; Pietralik, K.; Hryniewicz, K.

    2017-08-01

    This paper describes the implementation of a system consisting of a mobile application and RESTful architecture server intended for the analysis and presentation of quasars' spectrum. It also depicts the quasar's characteristics and significance to the scientific community, the source for acquiring astronomical objects' spectral data, used software solutions as well as presents the aspect of Cloud Computing and various possible deployment configurations.

  1. Recognizing mild cognitive impairment based on network connectivity analysis of resting EEG with zero reference

    International Nuclear Information System (INIS)

    Xu, Peng; Xiong, Xiu Chun; Tian, Yin; Zhang, Rui; Li, Pei Yang; Yao, De Zhong; Xue, Qing; Wang, Yu Ping; Peng, Yueheng

    2014-01-01

    The diagnosis of mild cognitive impairment (MCI) is very helpful for early therapeutic interventions of Alzheimer's disease (AD). MCI has been proven to be correlated with disorders in multiple brain areas. In this paper, we used information from resting brain networks at different EEG frequency bands to reliably recognize MCI. Because EEG network analysis is influenced by the reference that is used, we also evaluate the effect of the reference choices on the resting scalp EEG network-based MCI differentiation. The conducted study reveals two aspects: (1) the network-based MCI differentiation is superior to the previously reported classification that uses coherence in the EEG; and (2) the used EEG reference influences the differentiation performance, and the zero approximation technique (reference electrode standardization technique, REST) can construct a more accurate scalp EEG network, which results in a higher differentiation accuracy for MCI. This study indicates that the resting scalp EEG-based network analysis could be valuable for MCI recognition in the future. (paper)

  2. A Meta-analysis on Resting State High-frequency Heart Rate Variability in Bulimia Nervosa.

    Science.gov (United States)

    Peschel, Stephanie K V; Feeling, Nicole R; Vögele, Claus; Kaess, Michael; Thayer, Julian F; Koenig, Julian

    2016-09-01

    Autonomic nervous system function is altered in eating disorders. We aimed to quantify differences in resting state vagal activity, indexed by high-frequency heart rate variability comparing patients with bulimia nervosa (BN) and healthy controls. A systematic search of the literature to identify studies eligible for inclusion and meta-analytical methods were applied. Meta-regression was used to identify potential covariates. Eight studies reporting measures of resting high-frequency heart rate variability in individuals with BN (n = 137) and controls (n = 190) were included. Random-effects meta-analysis revealed a sizeable main effect (Z = 2.22, p = .03; Hedge's g = 0.52, 95% CI [0.06;0.98]) indicating higher resting state vagal activity in individuals with BN. Meta-regression showed that body mass index and medication intake are significant covariates. Findings suggest higher vagal activity in BN at rest, particularly in unmedicated samples with lower body mass index. Potential mechanisms underlying these findings and implications for routine clinical care are discussed. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.

  3. Resting-state theta band connectivity and graph analysis in generalized social anxiety disorder.

    Science.gov (United States)

    Xing, Mengqi; Tadayonnejad, Reza; MacNamara, Annmarie; Ajilore, Olusola; DiGangi, Julia; Phan, K Luan; Leow, Alex; Klumpp, Heide

    2017-01-01

    Functional magnetic resonance imaging (fMRI) resting-state studies show generalized social anxiety disorder (gSAD) is associated with disturbances in networks involved in emotion regulation, emotion processing, and perceptual functions, suggesting a network framework is integral to elucidating the pathophysiology of gSAD. However, fMRI does not measure the fast dynamic interconnections of functional networks. Therefore, we examined whole-brain functional connectomics with electroencephalogram (EEG) during resting-state. Resting-state EEG data was recorded for 32 patients with gSAD and 32 demographically-matched healthy controls (HC). Sensor-level connectivity analysis was applied on EEG data by using Weighted Phase Lag Index (WPLI) and graph analysis based on WPLI was used to determine clustering coefficient and characteristic path length to estimate local integration and global segregation of networks. WPLI results showed increased oscillatory midline coherence in the theta frequency band indicating higher connectivity in the gSAD relative to HC group during rest. Additionally, WPLI values positively correlated with state anxiety levels within the gSAD group but not the HC group. Our graph theory based connectomics analysis demonstrated increased clustering coefficient and decreased characteristic path length in theta-based whole brain functional organization in subjects with gSAD compared to HC. Theta-dependent interconnectivity was associated with state anxiety in gSAD and an increase in information processing efficiency in gSAD (compared to controls). Results may represent enhanced baseline self-focused attention, which is consistent with cognitive models of gSAD and fMRI studies implicating emotion dysregulation and disturbances in task negative networks (e.g., default mode network) in gSAD.

  4. Bound and scattering states with non-local potentials.

    Energy Technology Data Exchange (ETDEWEB)

    Viviani, M; Girlanda, L; Kievsky, A; Marcucci, L E; Rosati, S; Schiavilla, R

    2007-06-01

    The application of the hyperspherical harmonics method to the case of non-local potentials is described. Given the properties of the hyperspherical harmonic functions, there are no difficulties in considering the approach in both coordinate and momentum space. The results for the 3H and 4He binding energies and n - 3H scattering lengths are found to be in good agreement with those obtained with other different techniques. A study of the 4He form factor is also reported, with a careful investigation of the contribution from isospin symmetry violation. Its effect on parity violating elastic scattering of polarized electrons from 4He is investigated. In particular, a simple analysis of the recently measured left-right asymmetry at low Q2 shows that the contribution of these isospin admixture are found of comparable magnitude to that associated with strangeness components in the nucleon electric form factor.

  5. Large-scale Granger causality analysis on resting-state functional MRI

    Science.gov (United States)

    D'Souza, Adora M.; Abidin, Anas Zainul; Leistritz, Lutz; Wismüller, Axel

    2016-03-01

    We demonstrate an approach to measure the information flow between each pair of time series in resting-state functional MRI (fMRI) data of the human brain and subsequently recover its underlying network structure. By integrating dimensionality reduction into predictive time series modeling, large-scale Granger Causality (lsGC) analysis method can reveal directed information flow suggestive of causal influence at an individual voxel level, unlike other multivariate approaches. This method quantifies the influence each voxel time series has on every other voxel time series in a multivariate sense and hence contains information about the underlying dynamics of the whole system, which can be used to reveal functionally connected networks within the brain. To identify such networks, we perform non-metric network clustering, such as accomplished by the Louvain method. We demonstrate the effectiveness of our approach to recover the motor and visual cortex from resting state human brain fMRI data and compare it with the network recovered from a visuomotor stimulation experiment, where the similarity is measured by the Dice Coefficient (DC). The best DC obtained was 0.59 implying a strong agreement between the two networks. In addition, we thoroughly study the effect of dimensionality reduction in lsGC analysis on network recovery. We conclude that our approach is capable of detecting causal influence between time series in a multivariate sense, which can be used to segment functionally connected networks in the resting-state fMRI.

  6. Whole brain resting-state analysis reveals decreased functional connectivity in major depression

    Directory of Open Access Journals (Sweden)

    Ilya M. Veer

    2010-09-01

    Full Text Available Recently, both increases and decreases in resting-state functional connectivity have been found in major depression. However, these studies only assessed functional connectivity within a specific network or between a few regions of interest, while comorbidity and use of medication was not always controlled for. Therefore, the aim of the current study was to investigate whole-brain functional connectivity, unbiased by a priori definition of regions or networks of interest, in medication-free depressive patients without comorbidity. We analyzed resting-state fMRI data of 19 medication-free patients with a recent diagnosis of major depression (within six months before inclusion and no comorbidity, and 19 age- and gender-matched controls. Independent component analysis was employed on the concatenated data sets of all participants. Thirteen functionally relevant networks were identified, describing the entire study sample. Next, individual representations of the networks were created using a dual regression method. Statistical inference was subsequently done on these spatial maps using voxelwise permutation tests. Abnormal functional connectivity was found within three resting-state networks in depression: 1 decreased bilateral amygdala and left anterior insula connectivity in an affective network, 2 reduced connectivity of the left frontal pole in a network associated with attention and working memory, and 3 decreased bilateral lingual gyrus connectivity within ventromedial visual regions. None of these effects were associated with symptom severity or grey matter density. We found abnormal resting-state functional connectivity not previously associated with major depression, which might relate to abnormal affect regulation and mild cognitive deficits, both associated with the symptomatology of the disorder.

  7. Mermin Non-Locality in Abstract Process Theories

    Directory of Open Access Journals (Sweden)

    Stefano Gogioso

    2015-11-01

    Full Text Available The study of non-locality is fundamental to the understanding of quantum mechanics. The past 50 years have seen a number of non-locality proofs, but its fundamental building blocks, and the exact role it plays in quantum protocols, has remained elusive. In this paper, we focus on a particular flavour of non-locality, generalising Mermin's argument on the GHZ state. Using strongly complementary observables, we provide necessary and sufficient conditions for Mermin non-locality in abstract process theories. We show that the existence of more phases than classical points (aka eigenstates is not sufficient, and that the key to Mermin non-locality lies in the presence of certain algebraically non-trivial phases. This allows us to show that fRel, a favourite toy model for categorical quantum mechanics, is Mermin local. We show Mermin non-locality to be the key resource ensuring the device-independent security of the HBB CQ (N,N family of Quantum Secret Sharing protocols. Finally, we challenge the unspoken assumption that the measurements involved in Mermin-type scenarios should be complementary (like the pair X,Y, opening the doors to a much wider class of potential experimental setups than currently employed. In short, we give conditions for Mermin non-locality tests on any number of systems, where each party has an arbitrary number of measurement choices, where each measurement has an arbitrary number of outcomes and further, that works in any abstract process theory.

  8. Variational Framework for Non-Local Inpainting

    Directory of Open Access Journals (Sweden)

    Vadim Fedorov

    2015-12-01

    Full Text Available Image inpainting aims to obtain a visually plausible image interpolation in a region of the image in which data is missing due to damage or occlusion. Usually, the only available information is the portion of the image outside the inpainting domain. Besides its numerous applications,the inpainting problem is of theoretical interest since its analysis involves an understanding of the self-similarity present in natural images. In this work, we present a detailed description and implementation of three exemplar-based inpainting methods derived from the variational framework introduced by Arias et al.

  9. Analysis of Arterial Mechanics During Head-down Tilt Bed Rest

    Science.gov (United States)

    Elliot, Morgan; Martin, David S.; Westby, Christian M.; Stenger, Michael B.; Platts, Steve

    2014-01-01

    Arterial health may be affected by microgravity or ground based analogs of spaceflight, as shown by an increase in thoracic aorta stiffness1. Head-down tilt bed rest (HDTBR) is often used as a ground-based simulation of spaceflight because it induces physiological changes similar to those that occur in space2, 3. This abstract details an analysis of arterial stiffness (a subclinical measure of atherosclerosis), the distensibility coefficient (DC), and the pressure-strain elastic modulus (PSE) of the arterial walls during HDTBR. This project may help determine how spaceflight differentially affects arterial function in the upper vs. lower body.

  10. EFFECTS OF LORAZEPAM ON CARDIAC VAGAL TONE DURING REST AND MENTAL STRESS - ASSESSMENT BY MEANS OF SPECTRAL-ANALYSIS

    NARCIS (Netherlands)

    TULEN, JHM; MULDER, G; PEPPLINKHUIZEN, L; INTVELD, AJM; VANSTEENIS, HG; MOLEMAN, P

    Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine

  11. Effects of lorazepam on cardiac vagal tone during rest and mental stress: assessment by means of spectral analysis

    NARCIS (Netherlands)

    J.H.M. Tulen (Joke); G. Mulder (G.); L. Pepplinkhuizen (Lolke); A.J. Man in't Veld (A.); H.G. van Steenis (H.); P. Moleman (Peter)

    1994-01-01

    textabstractDose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after

  12. Non-local means filter for trim statics

    KAUST Repository

    Huang, Yunsong; Wang, Xin; Schuster, Gerard T.

    2014-01-01

    this problem, we propose a trim statics inspired by the non-local means algorithm originally developed for image denoising. This method differs from the conventional one in two fundamental respects. First, the trim statics are computed by comparing image

  13. Heritability estimates on resting state fMRI data using ENIGMA analysis pipeline.

    Science.gov (United States)

    Adhikari, Bhim M; Jahanshad, Neda; Shukla, Dinesh; Glahn, David C; Blangero, John; Reynolds, Richard C; Cox, Robert W; Fieremans, Els; Veraart, Jelle; Novikov, Dmitry S; Nichols, Thomas E; Hong, L Elliot; Thompson, Paul M; Kochunov, Peter

    2018-01-01

    Big data initiatives such as the Enhancing NeuroImaging Genetics through Meta-Analysis consortium (ENIGMA), combine data collected by independent studies worldwide to achieve more generalizable estimates of effect sizes and more reliable and reproducible outcomes. Such efforts require harmonized image analyses protocols to extract phenotypes consistently. This harmonization is particularly challenging for resting state fMRI due to the wide variability of acquisition protocols and scanner platforms; this leads to site-to-site variance in quality, resolution and temporal signal-to-noise ratio (tSNR). An effective harmonization should provide optimal measures for data of different qualities. We developed a multi-site rsfMRI analysis pipeline to allow research groups around the world to process rsfMRI scans in a harmonized way, to extract consistent and quantitative measurements of connectivity and to perform coordinated statistical tests. We used the single-modality ENIGMA rsfMRI preprocessing pipeline based on modelfree Marchenko-Pastur PCA based denoising to verify and replicate resting state network heritability estimates. We analyzed two independent cohorts, GOBS (Genetics of Brain Structure) and HCP (the Human Connectome Project), which collected data using conventional and connectomics oriented fMRI protocols, respectively. We used seed-based connectivity and dual-regression approaches to show that the rsfMRI signal is consistently heritable across twenty major functional network measures. Heritability values of 20-40% were observed across both cohorts.

  14. Evidence of Non-local Chemical, Thermal and Gravitational Effects

    Directory of Open Access Journals (Sweden)

    Hu H.

    2007-04-01

    Full Text Available Quantum entanglement is ubiquitous in the microscopic world and manifests itself macroscopically under some circumstances. But common belief is that it alone cannot be used to transmit information nor could it be used to produce macroscopic non- local effects. Yet we have recently found evidence of non-local effects of chemical substances on the brain produced through it. While our reported results are under independent verifications by other groups, we report here our experimental findings of non-local chemical, thermal and gravitational effects in simple physical systems such as reservoirs of water quantum-entangled with water being manipulated in a remote reservoir. With the aids of high-precision instruments, we have found that the pH value, temperature and gravity of water in the detecting reservoirs can be non-locally affected through manipulating water in the remote reservoir. In particular, the pH value changes in the same direction as that being manipulated; the temperature can change against that of local environment; and the gravity apparently can also change against local gravity. These non-local effects are all reproducible and can be used for non-local signalling and many other purposes. We suggest that they are mediated by quantum entanglement between nuclear and/or electron spins in treated water and discuss the implications of these results.

  15. A Systems-Theoretical Generalization of Non-Local Correlations

    Science.gov (United States)

    von Stillfried, Nikolaus

    Non-local correlations between quantum events are not due to a causal interaction in the sense of one being the cause for the other. In principle, the correlated events can thus occur simultaneously. Generalized Quantum Theory (GQT) formalizes the idea that non-local phenomena are not exclusive to quantum mechanics, e.g. due to some specific properties of (sub)atomic particles, but that they instead arise as a consequence of the way such particles are arranged into systems. Non-local phenomena should hence occur in any system which fulfils the necessary systems-theoretical parameters. The two most important parameters with respect to non-local correlations seem to be a conserved global property of the system as a whole and sufficient degrees of freedom of the corresponding property of its subsystems. Both factors place severe limitations on experimental observability of the phenomena, especially in terms of replicability. It has been suggested that reported phenomena of a so-called synchronistic, parapsychological or paranormal kind could be understood as instances of systems-inherent non-local correlations. From a systems-theoretical perspective, their phenomenology (including the favorable conditions for their occurrence and their lack of replicability) displays substantial similarities to non-local correlations in quantum systems and matches well with systems-theoretical parameters, thus providing circumstantial evidence for this hypothesis.

  16. More about the comparison of local and non-local NN interaction models

    International Nuclear Information System (INIS)

    Amghar, A.; Desplanques, B.

    2003-01-01

    The effect of non-locality in the NN interaction with an off-energy shell character has been studied in the past in relation with the possibility that some models could be approximately phase-shifts equivalent. This work is extended to a non-locality implying terms that involve an anticommutator with the operator p 2 . It includes both scalar and tensor components. The most recent 'high accuracy' models are considered in the analysis. After studying the deuteron wave functions, electromagnetic properties of various models are compared with the idea that these ones differ by their non-locality but are equivalent up to a unitary transformation. It is found that the extra non-local tensor interaction considered in this work tends to re-enforce the role of the term considered in previous works, allowing one to explain almost completely the difference in the deuteron D-state probabilities evidenced by the comparison of the Bonn-QB and Paris models for instance. Conclusions for the effect of the non-local scalar interaction are not so clear. In many cases, it was found that these terms could explain part of the differences that the comparison of predictions for various models evidences but cases where they could not were also found. Some of these last ones have been analyzed in order to pointing out the origin of the failure

  17. [Resting metabolic rate estimated by bioelectrical impedance analysis and its determinants in maintenance hemodialysis patients].

    Science.gov (United States)

    Da, J J; Peng, H Y; Lin, X; Shen, Y; Zhao, J Q; He, S; Zha, Y

    2018-03-27

    Objective: To explore the level of resting energy expenditure (REE) estimated by bioelectrical impedance analysis and the association of resting metabolic rate (RMR) with clinical related factors, and provide new ideas for improving protein energy wasting (PEW) in maintenance hemodialysis (MHD) patients. Methods: Seven hundred and sixty-five subjects receiving MHD between July 2015 and September 2016 in 11 hemodialysis centers in Guizhou province were enrolled in this cross-sectional study. Bioelectrical impedance analysis was used to measure RMR and body composition, such as lean body mass, fat mass and body cell mass (BCM). Baseline characteristics, routine blood test indexes and biochemical data of hemodialysis patients were collected. The level of RMR and body composition in hemodialysis patients was compared by gender grouping. Then the patients were divided into four groups according to the cutoff value of RMR quartile. Spearman correlation analysis and multiple linear regression analysis were used to analyze the relationships between RMR and clinical related factors. Results: The average age of MHD patients was (54.96±15.78) years and the duriation of dialysis was (42.3±9.0) months. The level of RMR in male patients (474 cases, 61.96%) was significantly higher than that in female patients [1 591(1 444, 1 764) kcal/d vs 1 226 (1 104, 1 354) kcal/d, P lean body mass ( P =0.193). Multiple linear regression analysis showed that RMR was positively correlated with body surface area (β=0.817) and lactate dehydrogenase (LDH) (β=0.198), and negatively correlated with age (β=-0.141), all P maintenance hemodialysis are associated with lactate dehydrogenase level, which may become a new index to evaluate energy consumption.

  18. The value of radionuclide phase analysis and parameters of cardial function for diagnosis CAD at rest and during exercise

    International Nuclear Information System (INIS)

    Huang Gang

    1990-01-01

    27 patients and 5 normal were studied with ECG-gated cardial blood pool images and radionuclide phase analysis at rest and during exercise. The results showed that the sensitivity of LVEF in CAD at rest and during exercise were 57% and 71% respectively, and the sensitivity of the ventricular phase in CAD were 79% at rest and 90% during exercise, and the sensitivity of phase angle in CAD were higher than of LVEF. This suggested that the ventricular phase angle was important for diagnosing early CAD. In addition, regional EF, phase image and ventricular wall motion were useful to detect the lesion of ischemia in CAD

  19. Free vibration analysis of magneto-electro-thermo-elastic nanobeams resting on a Pasternak foundation

    Science.gov (United States)

    Jandaghian, A. A.; Rahmani, O.

    2016-03-01

    In this study, free vibration analysis of magneto-electro-thermo-elastic (METE) nanobeams resting on a Pasternak foundation is investigated based on nonlocal theory and Timoshenko beam theory. Coupling effects between electric, magnetic, mechanical and thermal loading are considered to derive the equations of motion and distribution of electrical potential and magnetic potential along the thickness direction of the METE nanobeam. The governing equations and boundary conditions are obtained using the Hamilton principle and discretized via the differential quadrature method (DQM). Numerical results reveal the effects of the nonlocal parameter, magneto-electro-thermo-mechanical loading, Winkler spring coefficients, Pasternak shear coefficients and height-to-length ratio on the vibration characteristics of METE nanobeams. It is observed that the natural frequency is dependent on the magnetic, electric, temperature, elastic medium, small-scale coefficient, and height-to-length ratio. These results are useful in the mechanical analysis and design of smart nanostructures constructed from magneto-electro-thermo-elastic materials.

  20. Non-Local Diffusion of Energetic Electrons during Solar Flares

    Science.gov (United States)

    Bian, N. H.; Emslie, G.; Kontar, E.

    2017-12-01

    The transport of the energy contained in suprathermal electrons in solar flares plays a key role in our understanding of many aspects of flare physics, from the spatial distributions of hard X-ray emission and energy deposition in the ambient atmosphere to global energetics. Historically the transport of these particles has been largely treated through a deterministic approach, in which first-order secular energy loss to electrons in the ambient target is treated as the dominant effect, with second-order diffusive terms (in both energy and angle) generally being either treated as a small correction or even neglected. Here, we critically analyze this approach, and we show that spatial diffusion through pitch-angle scattering necessarily plays a very significant role in the transport of electrons. We further show that a satisfactory treatment of the diffusion process requires consideration of non-local effects, so that the electron flux depends not just on the local gradient of the electron distribution function but on the value of this gradient within an extended region encompassing a significant fraction of a mean free path. Our analysis applies generally to pitch-angle scattering by a variety of mechanisms, from Coulomb collisions to turbulent scattering. We further show that the spatial transport of electrons along the magnetic field of a flaring loop can be modeled as a Continuous Time Random Walk with velocity-dependent probability distribution functions of jump sizes and occurrences, both of which can be expressed in terms of the scattering mean free path.

  1. Resting-state brain activity in the motor cortex reflects task-induced activity: A multi-voxel pattern analysis.

    Science.gov (United States)

    Kusano, Toshiki; Kurashige, Hiroki; Nambu, Isao; Moriguchi, Yoshiya; Hanakawa, Takashi; Wada, Yasuhiro; Osu, Rieko

    2015-08-01

    It has been suggested that resting-state brain activity reflects task-induced brain activity patterns. In this study, we examined whether neural representations of specific movements can be observed in the resting-state brain activity patterns of motor areas. First, we defined two regions of interest (ROIs) to examine brain activity associated with two different behavioral tasks. Using multi-voxel pattern analysis with regularized logistic regression, we designed a decoder to detect voxel-level neural representations corresponding to the tasks in each ROI. Next, we applied the decoder to resting-state brain activity. We found that the decoder discriminated resting-state neural activity with accuracy comparable to that associated with task-induced neural activity. The distribution of learned weighted parameters for each ROI was similar for resting-state and task-induced activities. Large weighted parameters were mainly located on conjunctive areas. Moreover, the accuracy of detection was higher than that for a decoder whose weights were randomly shuffled, indicating that the resting-state brain activity includes multi-voxel patterns similar to the neural representation for the tasks. Therefore, these results suggest that the neural representation of resting-state brain activity is more finely organized and more complex than conventionally considered.

  2. The morphing method as a flexible tool for adaptive local/non-local simulation of static fracture

    KAUST Repository

    Azdoud, Yan

    2014-04-19

    We introduce a framework that adapts local and non-local continuum models to simulate static fracture problems. Non-local models based on the peridynamic theory are promising for the simulation of fracture, as they allow discontinuities in the displacement field. However, they remain computationally expensive. As an alternative, we develop an adaptive coupling technique based on the morphing method to restrict the non-local model adaptively during the evolution of the fracture. The rest of the structure is described by local continuum mechanics. We conduct all simulations in three dimensions, using the relevant discretization scheme in each domain, i.e., the discontinuous Galerkin finite element method in the peridynamic domain and the continuous finite element method in the local continuum mechanics domain. © 2014 Springer-Verlag Berlin Heidelberg.

  3. On a non-local gas dynamics like integrable hierarchy

    International Nuclear Information System (INIS)

    Brunelli, Jose Carlos; Das, Ashok

    2004-01-01

    We study a new hierarchy of equations derived from the system of isentropic gas dynamics equations where the pressure is a non-local function of the density. We show that the hierarchy of equations is integrable. We construct the two compatible Hamiltonian structures and show that the first structure has three distinct Casimirs while the second has one. The existence of Casimirs allows us to extend the flows to local ones. We construct an infinite series of commuting local Hamiltonians as well as three infinite series (related to the three Casimirs) of non-local charges. We discuss the zero curvature formulation of the system where we obtain a simple expression for the non-local conserved charges, which also clarifies the existence of the three series from a Lie algebraic point of view. We point out that the non-local hierarchy of Hunter-Zheng equations can be obtained from our non-local flows when the dynamical variables are properly constrained. (author)

  4. Non-local magnetoresistance in YIG/Pt nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Goennenwein, Sebastian T. B., E-mail: goennenwein@wmi.badw.de; Pernpeintner, Matthias; Gross, Rudolf; Huebl, Hans [Walther-Meißner-Institut, Bayerische Akademie der Wissenschaften, Walther-Meißner-Str. 8, 85748 Garching (Germany); Nanosystems Initiative Munich (NIM), Schellingstraße 4, 80799 München (Germany); Physik-Department, Technische Universität München, James-Franck-Str. 1, 85748 Garching (Germany); Schlitz, Richard; Ganzhorn, Kathrin [Walther-Meißner-Institut, Bayerische Akademie der Wissenschaften, Walther-Meißner-Str. 8, 85748 Garching (Germany); Physik-Department, Technische Universität München, James-Franck-Str. 1, 85748 Garching (Germany); Althammer, Matthias [Walther-Meißner-Institut, Bayerische Akademie der Wissenschaften, Walther-Meißner-Str. 8, 85748 Garching (Germany)

    2015-10-26

    We study the local and non-local magnetoresistance of thin Pt strips deposited onto yttrium iron garnet. The local magnetoresistive response, inferred from the voltage drop measured along one given Pt strip upon current-biasing it, shows the characteristic magnetization orientation dependence of the spin Hall magnetoresistance. We simultaneously also record the non-local voltage appearing along a second, electrically isolated, Pt strip, separated from the current carrying one by a gap of a few 100 nm. The corresponding non-local magnetoresistance exhibits the symmetry expected for a magnon spin accumulation-driven process, confirming the results recently put forward by Cornelissen et al. [“Long-distance transport of magnon spin information in a magnetic insulator at room temperature,” Nat. Phys. (published online 14 September 2015)]. Our magnetotransport data, taken at a series of different temperatures as a function of magnetic field orientation, rotating the externally applied field in three mutually orthogonal planes, show that the mechanisms behind the spin Hall and the non-local magnetoresistance are qualitatively different. In particular, the non-local magnetoresistance vanishes at liquid Helium temperatures, while the spin Hall magnetoresistance prevails.

  5. A Methodology for the Development of RESTful Semantic Web Services for Gene Expression Analysis.

    Science.gov (United States)

    Guardia, Gabriela D A; Pires, Luís Ferreira; Vêncio, Ricardo Z N; Malmegrim, Kelen C R; de Farias, Cléver R G

    2015-01-01

    Gene expression studies are generally performed through multi-step analysis processes, which require the integrated use of a number of analysis tools. In order to facilitate tool/data integration, an increasing number of analysis tools have been developed as or adapted to semantic web services. In recent years, some approaches have been defined for the development and semantic annotation of web services created from legacy software tools, but these approaches still present many limitations. In addition, to the best of our knowledge, no suitable approach has been defined for the functional genomics domain. Therefore, this paper aims at defining an integrated methodology for the implementation of RESTful semantic web services created from gene expression analysis tools and the semantic annotation of such services. We have applied our methodology to the development of a number of services to support the analysis of different types of gene expression data, including microarray and RNASeq. All developed services are publicly available in the Gene Expression Analysis Services (GEAS) Repository at http://dcm.ffclrp.usp.br/lssb/geas. Additionally, we have used a number of the developed services to create different integrated analysis scenarios to reproduce parts of two gene expression studies documented in the literature. The first study involves the analysis of one-color microarray data obtained from multiple sclerosis patients and healthy donors. The second study comprises the analysis of RNA-Seq data obtained from melanoma cells to investigate the role of the remodeller BRG1 in the proliferation and morphology of these cells. Our methodology provides concrete guidelines and technical details in order to facilitate the systematic development of semantic web services. Moreover, it encourages the development and reuse of these services for the creation of semantically integrated solutions for gene expression analysis.

  6. A Methodology for the Development of RESTful Semantic Web Services for Gene Expression Analysis.

    Directory of Open Access Journals (Sweden)

    Gabriela D A Guardia

    Full Text Available Gene expression studies are generally performed through multi-step analysis processes, which require the integrated use of a number of analysis tools. In order to facilitate tool/data integration, an increasing number of analysis tools have been developed as or adapted to semantic web services. In recent years, some approaches have been defined for the development and semantic annotation of web services created from legacy software tools, but these approaches still present many limitations. In addition, to the best of our knowledge, no suitable approach has been defined for the functional genomics domain. Therefore, this paper aims at defining an integrated methodology for the implementation of RESTful semantic web services created from gene expression analysis tools and the semantic annotation of such services. We have applied our methodology to the development of a number of services to support the analysis of different types of gene expression data, including microarray and RNASeq. All developed services are publicly available in the Gene Expression Analysis Services (GEAS Repository at http://dcm.ffclrp.usp.br/lssb/geas. Additionally, we have used a number of the developed services to create different integrated analysis scenarios to reproduce parts of two gene expression studies documented in the literature. The first study involves the analysis of one-color microarray data obtained from multiple sclerosis patients and healthy donors. The second study comprises the analysis of RNA-Seq data obtained from melanoma cells to investigate the role of the remodeller BRG1 in the proliferation and morphology of these cells. Our methodology provides concrete guidelines and technical details in order to facilitate the systematic development of semantic web services. Moreover, it encourages the development and reuse of these services for the creation of semantically integrated solutions for gene expression analysis.

  7. A non-local variable for general relativity

    International Nuclear Information System (INIS)

    Kozameh, C.N.; Newman, E.T.

    1983-01-01

    The usual description of differential geometry and general relativity is in terms of local fields, e.g. the metric, the curvature tensor, etc, which satisfy local differential equations. The authors introduce a new non-local field (Z) from which the local fields can be derived. Basically Z, though it is non-local, should be thought of as a function on the bundle of null directions on a space-time. The program can be divided into two parts; first the authors want to show the geometric meaning of and the relationship between Z and the local field. Then they want to provide field equations (non-local) for Z which will be equivalent to the vacuum Einstein equations for the local field. (Auth.)

  8. Non-local quantal Noether identities and their applications

    International Nuclear Information System (INIS)

    Li Ziping

    2002-01-01

    Based on the phase-space generating functional for a system with a singular high-order Lagrangian, the quantal canonical Noether identities under the local and non-local transformation in phase space for such system have been derived. For a gauge-invariant system with a higher-order Lagrangian, the quantal Noether identities under the local and non-local transformation in configuration space have also been derived. it has been pointed out that in certain cases the quantal Noether identities may be converted to the conservation laws at the quantum level. This algorithm to derive the quantal conservation laws is significantly different from the first quantal Noether theorem. The applications to the non-Abelian CS theories with higher-order derivatives are given. The conserved quantities at the quantum level for some local and non-local transformation are found respectively

  9. Non-locality of non-Abelian anyons

    International Nuclear Information System (INIS)

    Brennen, G K; Iblisdir, S; Pachos, J K; Slingerland, J K

    2009-01-01

    Entangled states of quantum systems can give rise to measurement correlations of separated observers that cannot be described by local hidden variable theories. Usually, it is assumed that entanglement between particles is generated due to some distance-dependent interaction. Yet anyonic particles in two dimensions have a nontrivial interaction that is purely topological in nature. In other words, it does not depend on the distance between two particles, but rather on their exchange history. The information encoded in anyons is inherently non-local even in the single subsystem level making the treatment of anyons non-conventional. We describe a protocol to reveal the non-locality of anyons in terms of correlations in the outcomes of measurements in two separated regions. This gives a clear operational measure of non-locality for anyonic states and it opens up the possibility to test Bell inequalities in quantum Hall liquids or spin lattices.

  10. Non-locality of non-Abelian anyons

    Science.gov (United States)

    Brennen, G. K.; Iblisdir, S.; Pachos, J. K.; Slingerland, J. K.

    2009-10-01

    Entangled states of quantum systems can give rise to measurement correlations of separated observers that cannot be described by local hidden variable theories. Usually, it is assumed that entanglement between particles is generated due to some distance-dependent interaction. Yet anyonic particles in two dimensions have a nontrivial interaction that is purely topological in nature. In other words, it does not depend on the distance between two particles, but rather on their exchange history. The information encoded in anyons is inherently non-local even in the single subsystem level making the treatment of anyons non-conventional. We describe a protocol to reveal the non-locality of anyons in terms of correlations in the outcomes of measurements in two separated regions. This gives a clear operational measure of non-locality for anyonic states and it opens up the possibility to test Bell inequalities in quantum Hall liquids or spin lattices.

  11. Characterizing Alzheimer's disease severity via resting-awake EEG amplitude modulation analysis.

    Directory of Open Access Journals (Sweden)

    Francisco J Fraga

    Full Text Available Changes in electroencephalography (EEG amplitude modulations have recently been linked with early-stage Alzheimer's disease (AD. Existing tools available to perform such analysis (e.g., detrended fluctuation analysis, however, provide limited gains in discriminability power over traditional spectral based EEG analysis. In this paper, we explore the use of an innovative EEG amplitude modulation analysis technique based on spectro-temporal signal processing. More specifically, full-band EEG signals are first decomposed into the five well-known frequency bands and the envelopes are then extracted via a Hilbert transform. Each of the five envelopes are further decomposed into four so-called modulation bands, which were chosen to coincide with the delta, theta, alpha and beta frequency bands. Experiments on a resting-awake EEG dataset collected from 76 participants (27 healthy controls, 27 diagnosed with mild-AD, and 22 with moderate-AD showed significant differences in amplitude modulations between the three groups. Most notably, i delta modulation of the beta frequency band disappeared with an increase in disease severity (from mild to moderate AD, ii delta modulation of the theta band appeared with an increase in severity, and iii delta modulation of the beta frequency band showed to be a reliable discriminant feature between healthy controls and mild-AD patients. Taken together, it is hoped that the developed tool can be used to assist clinicians not only with early detection of Alzheimer's disease, but also to monitor its progression.

  12. To the non-local theory of cold nuclear fusion.

    Science.gov (United States)

    Alexeev, Boris V

    2014-10-01

    In this paper, we revisit the cold fusion (CF) phenomenon using the generalized Bolzmann kinetics theory which can represent the non-local physics of this CF phenomenon. This approach can identify the conditions when the CF can take place as the soliton creation under the influence of the intensive sound waves. The vast mathematical modelling leads to affirmation that all parts of soliton move with the same velocity and with the small internal change of the pressure. The zone of the high density is shaped on the soliton's front. It means that the regime of the 'acoustic CF' could be realized from the position of the non-local hydrodynamics.

  13. Single-trial log transformation is optimal in frequency analysis of resting EEG alpha.

    Science.gov (United States)

    Smulders, Fren T Y; Ten Oever, Sanne; Donkers, Franc C L; Quaedflieg, Conny W E M; van de Ven, Vincent

    2018-02-01

    The appropriate definition and scaling of the magnitude of electroencephalogram (EEG) oscillations is an underdeveloped area. The aim of this study was to optimize the analysis of resting EEG alpha magnitude, focusing on alpha peak frequency and nonlinear transformation of alpha power. A family of nonlinear transforms, Box-Cox transforms, were applied to find the transform that (a) maximized a non-disputed effect: the increase in alpha magnitude when the eyes are closed (Berger effect), and (b) made the distribution of alpha magnitude closest to normal across epochs within each participant, or across participants. The transformations were performed either at the single epoch level or at the epoch-average level. Alpha peak frequency showed large individual differences, yet good correspondence between various ways to estimate it in 2 min of eyes-closed and 2 min of eyes-open resting EEG data. Both alpha magnitude and the Berger effect were larger for individual alpha than for a generic (8-12 Hz) alpha band. The log-transform on single epochs (a) maximized the t-value of the contrast between the eyes-open and eyes-closed conditions when tested within each participant, and (b) rendered near-normally distributed alpha power across epochs and participants, thereby making further transformation of epoch averages superfluous. The results suggest that the log-normal distribution is a fundamental property of variations in alpha power across time in the order of seconds. Moreover, effects on alpha power appear to be multiplicative rather than additive. These findings support the use of the log-transform on single epochs to achieve appropriate scaling of alpha magnitude. © 2018 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  14. Resting-state functional magnetic resonance imaging: the impact of regression analysis.

    Science.gov (United States)

    Yeh, Chia-Jung; Tseng, Yu-Sheng; Lin, Yi-Ru; Tsai, Shang-Yueh; Huang, Teng-Yi

    2015-01-01

    To investigate the impact of regression methods on resting-state functional magnetic resonance imaging (rsfMRI). During rsfMRI preprocessing, regression analysis is considered effective for reducing the interference of physiological noise on the signal time course. However, it is unclear whether the regression method benefits rsfMRI analysis. Twenty volunteers (10 men and 10 women; aged 23.4 ± 1.5 years) participated in the experiments. We used node analysis and functional connectivity mapping to assess the brain default mode network by using five combinations of regression methods. The results show that regressing the global mean plays a major role in the preprocessing steps. When a global regression method is applied, the values of functional connectivity are significantly lower (P ≤ .01) than those calculated without a global regression. This step increases inter-subject variation and produces anticorrelated brain areas. rsfMRI data processed using regression should be interpreted carefully. The significance of the anticorrelated brain areas produced by global signal removal is unclear. Copyright © 2014 by the American Society of Neuroimaging.

  15. Analysis of R-R intervals in patients with atrial fibrillation at rest and during exercise

    NARCIS (Netherlands)

    Bootsma, B.K.; Hoelen, A.J.; Strackee, J.; Meijler, F.L.

    Serial autocorrelation functions and histograms of R-R intervals in patients with atrial fibrillation, with and without digitalis, at rest and during exercise, were produced by a computer. At rest with and without digitalis the first and higher order coefficients did not differ from zero. During

  16. Non-local means denoising of dynamic PET images.

    Directory of Open Access Journals (Sweden)

    Joyita Dutta

    Full Text Available Dynamic positron emission tomography (PET, which reveals information about both the spatial distribution and temporal kinetics of a radiotracer, enables quantitative interpretation of PET data. Model-based interpretation of dynamic PET images by means of parametric fitting, however, is often a challenging task due to high levels of noise, thus necessitating a denoising step. The objective of this paper is to develop and characterize a denoising framework for dynamic PET based on non-local means (NLM.NLM denoising computes weighted averages of voxel intensities assigning larger weights to voxels that are similar to a given voxel in terms of their local neighborhoods or patches. We introduce three key modifications to tailor the original NLM framework to dynamic PET. Firstly, we derive similarities from less noisy later time points in a typical PET acquisition to denoise the entire time series. Secondly, we use spatiotemporal patches for robust similarity computation. Finally, we use a spatially varying smoothing parameter based on a local variance approximation over each spatiotemporal patch.To assess the performance of our denoising technique, we performed a realistic simulation on a dynamic digital phantom based on the Digimouse atlas. For experimental validation, we denoised [Formula: see text] PET images from a mouse study and a hepatocellular carcinoma patient study. We compared the performance of NLM denoising with four other denoising approaches - Gaussian filtering, PCA, HYPR, and conventional NLM based on spatial patches.The simulation study revealed significant improvement in bias-variance performance achieved using our NLM technique relative to all the other methods. The experimental data analysis revealed that our technique leads to clear improvement in contrast-to-noise ratio in Patlak parametric images generated from denoised preclinical and clinical dynamic images, indicating its ability to preserve image contrast and high

  17. Non-local means denoising of dynamic PET images.

    Science.gov (United States)

    Dutta, Joyita; Leahy, Richard M; Li, Quanzheng

    2013-01-01

    Dynamic positron emission tomography (PET), which reveals information about both the spatial distribution and temporal kinetics of a radiotracer, enables quantitative interpretation of PET data. Model-based interpretation of dynamic PET images by means of parametric fitting, however, is often a challenging task due to high levels of noise, thus necessitating a denoising step. The objective of this paper is to develop and characterize a denoising framework for dynamic PET based on non-local means (NLM). NLM denoising computes weighted averages of voxel intensities assigning larger weights to voxels that are similar to a given voxel in terms of their local neighborhoods or patches. We introduce three key modifications to tailor the original NLM framework to dynamic PET. Firstly, we derive similarities from less noisy later time points in a typical PET acquisition to denoise the entire time series. Secondly, we use spatiotemporal patches for robust similarity computation. Finally, we use a spatially varying smoothing parameter based on a local variance approximation over each spatiotemporal patch. To assess the performance of our denoising technique, we performed a realistic simulation on a dynamic digital phantom based on the Digimouse atlas. For experimental validation, we denoised [Formula: see text] PET images from a mouse study and a hepatocellular carcinoma patient study. We compared the performance of NLM denoising with four other denoising approaches - Gaussian filtering, PCA, HYPR, and conventional NLM based on spatial patches. The simulation study revealed significant improvement in bias-variance performance achieved using our NLM technique relative to all the other methods. The experimental data analysis revealed that our technique leads to clear improvement in contrast-to-noise ratio in Patlak parametric images generated from denoised preclinical and clinical dynamic images, indicating its ability to preserve image contrast and high intensity details while

  18. RESTful NET

    CERN Document Server

    Flanders, Jon

    2008-01-01

    RESTful .NET is the first book that teaches Windows developers to build RESTful web services using the latest Microsoft tools. Written by Windows Communication Foundation (WFC) expert Jon Flanders, this hands-on tutorial demonstrates how you can use WCF and other components of the .NET 3.5 Framework to build, deploy and use REST-based web services in a variety of application scenarios. RESTful architecture offers a simpler approach to building web services than SOAP, SOA, and the cumbersome WS- stack. And WCF has proven to be a flexible technology for building distributed systems not necessa

  19. ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW.

    Science.gov (United States)

    Koch, Saskia B J; van Zuiden, Mirjam; Nawijn, Laura; Frijling, Jessie L; Veltman, Dick J; Olff, Miranda

    2016-07-01

    About 10% of trauma-exposed individuals develop PTSD. Although a growing number of studies have investigated resting-state abnormalities in PTSD, inconsistent results suggest a need for a meta-analysis and a systematic review. We conducted a systematic literature search in four online databases using keywords for PTSD, functional neuroimaging, and resting-state. In total, 23 studies matched our eligibility criteria. For the meta-analysis, we included 14 whole-brain resting-state studies, reporting data on 663 participants (298 PTSD patients and 365 controls). We used the activation likelihood estimation approach to identify concurrence of whole-brain hypo- and hyperactivations in PTSD patients during rest. Seed-based studies could not be included in the quantitative meta-analysis. Therefore, a separate qualitative systematic review was conducted on nine seed-based functional connectivity studies. The meta-analysis showed consistent hyperactivity in the ventral anterior cingulate cortex and the parahippocampus/amygdala, but hypoactivity in the (posterior) insula, cerebellar pyramis and middle frontal gyrus in PTSD patients, compared to healthy controls. Partly concordant with these findings, the systematic review on seed-based functional connectivity studies showed enhanced salience network (SN) connectivity, but decreased default mode network (DMN) connectivity in PTSD. Combined, these altered resting-state connectivity and activity patterns could represent neurobiological correlates of increased salience processing and hypervigilance (SN), at the cost of awareness of internal thoughts and autobiographical memory (DMN) in PTSD. However, several discrepancies between findings of the meta-analysis and systematic review were observed, stressing the need for future studies on resting-state abnormalities in PTSD patients. © 2016 Wiley Periodicals, Inc.

  20. Resting energy expenditure and body composition in children with cancer: indirect calorimetry and bioimpedance analysis

    Directory of Open Access Journals (Sweden)

    M. V. Konovalova

    2014-07-01

    Full Text Available Resting energy expenditure (REE by indirect calorimetry and body composition by bioimpedance analysis are studied in three groups of children aged 5–18 years. Group 1 (n = 181 – patients in remission of cancer, group 2 (n = 55 – children with oncology diseases receiving chemotherapy or who are in the early period after hematopoietic stem cell transplantation, group 3 (n = 63 – children with non-malignant diseases of the gastrointestinal tract. To eliminate the influence of age and gender on the intergroup comparisons, body composition parameters were expressed as standardized values (z-scores relative to a reference group of healthy Russian children (n = 138,191. Group 1 was characterized by excess fat content with intact lean body mass, and groups 2 and 3 by protein depletion, more pronounced in Group 2 with a higher percentage of body fat. All used conventional formulas (WHO, Harris–Benedict and others in groups 1 and 3 underestimated REE as compared with indirect calorimetry. A new formula for REE, giving an unbiased estimate in the group 1 was proposed: REE (kcal/day = 28.7 × BCM (kg +10.5 × Height (cm – 38.6 × Age (years – 134, where BCM – body cell mass according to bioimpedance analysis (R2 = 0.67, the standard deviation of 196 kcal/day.

  1. Free vibration analysis of magneto-electro-thermo-elastic nanobeams resting on a Pasternak foundation

    International Nuclear Information System (INIS)

    Jandaghian, A A; Rahmani, O

    2016-01-01

    In this study, free vibration analysis of magneto-electro-thermo-elastic (METE) nanobeams resting on a Pasternak foundation is investigated based on nonlocal theory and Timoshenko beam theory. Coupling effects between electric, magnetic, mechanical and thermal loading are considered to derive the equations of motion and distribution of electrical potential and magnetic potential along the thickness direction of the METE nanobeam. The governing equations and boundary conditions are obtained using the Hamilton principle and discretized via the differential quadrature method (DQM). Numerical results reveal the effects of the nonlocal parameter, magneto-electro-thermo-mechanical loading, Winkler spring coefficients, Pasternak shear coefficients and height-to-length ratio on the vibration characteristics of METE nanobeams. It is observed that the natural frequency is dependent on the magnetic, electric, temperature, elastic medium, small-scale coefficient, and height-to-length ratio. These results are useful in the mechanical analysis and design of smart nanostructures constructed from magneto-electro-thermo-elastic materials. (paper)

  2. Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest.

    Science.gov (United States)

    Sonner, Zachary; Wilder, Eliza; Gaillard, Trudy; Kasting, Gerald; Heikenfeld, Jason

    2017-07-25

    Eccrine sweat has rapidly emerged as a non-invasive, ergonomic, and rich source of chemical analytes with numerous technological demonstrations now showing the ability for continuous electrochemical sensing. However, beyond active perspirers (athletes, workers, etc.), continuous sweat access in individuals at rest has hindered the advancement of both sweat sensing science and technology. Reported here is integration of sudomotor axon reflex sweat stimulation for continuous wearable sweat analyte analysis, including the ability for side-by-side integration of chemical stimulants & sensors without cross-contamination. This integration approach is uniquely compatible with sensors which consume the analyte (enzymatic) or sensors which equilibrate with analyte concentrations. In vivo validation is performed using iontophoretic delivery of carbachol with ion-selective and impedance sensors for sweat analysis. Carbachol has shown prolonged sweat stimulation in directly stimulated regions for five hours or longer. This work represents a significant leap forward in sweat sensing technology, and may be of broader interest to those interested in on-skin sensing integrated with drug-delivery.

  3. Analysis of Arterial Mechanics During Head-Down-Tilt Bed Rest

    Science.gov (United States)

    Elliott, Morgan B.; Martin, David S.; Westby, Christian M.; Stenger, Michael B.; Platts, Steven H.

    2014-01-01

    Carotid, brachial, and tibial arteries reacted differently to HDTBR. Previous studies have not analyzed the mechanical properties of the human brachial or anterior tibial arteries. After slight variations during bed-rest, arterial mechanical properties and IMT returned to pre-bed rest values, with the exception of tibial stiffness and PSE, which continued to be reduced post-bed rest while the DC remained elevated. The tibial artery remodeling was probably due to decreased pressure and volume. Resulting implications for longer duration spaceflight are unclear. Arterial health may be affected by microgravity, as shown by increased thoracic aorta stiffness in other ground based simulations (Aubert).

  4. Brain resting-state networks in adolescents with high-functioning autism: Analysis of spatial connectivity and temporal neurodynamics.

    Science.gov (United States)

    Bernas, Antoine; Barendse, Evelien M; Aldenkamp, Albert P; Backes, Walter H; Hofman, Paul A M; Hendriks, Marc P H; Kessels, Roy P C; Willems, Frans M J; de With, Peter H N; Zinger, Svitlana; Jansen, Jacobus F A

    2018-02-01

    Autism spectrum disorder (ASD) is mainly characterized by functional and communication impairments as well as restrictive and repetitive behavior. The leading hypothesis for the neural basis of autism postulates globally abnormal brain connectivity, which can be assessed using functional magnetic resonance imaging (fMRI). Even in the absence of a task, the brain exhibits a high degree of functional connectivity, known as intrinsic, or resting-state, connectivity. Global default connectivity in individuals with autism versus controls is not well characterized, especially for a high-functioning young population. The aim of this study is to test whether high-functioning adolescents with ASD (HFA) have an abnormal resting-state functional connectivity. We performed spatial and temporal analyses on resting-state networks (RSNs) in 13 HFA adolescents and 13 IQ- and age-matched controls. For the spatial analysis, we used probabilistic independent component analysis (ICA) and a permutation statistical method to reveal the RSN differences between the groups. For the temporal analysis, we applied Granger causality to find differences in temporal neurodynamics. Controls and HFA display very similar patterns and strengths of resting-state connectivity. We do not find any significant differences between HFA adolescents and controls in the spatial resting-state connectivity. However, in the temporal dynamics of this connectivity, we did find differences in the causal effect properties of RSNs originating in temporal and prefrontal cortices. The results show a difference between HFA and controls in the temporal neurodynamics from the ventral attention network to the salience-executive network: a pathway involving cognitive, executive, and emotion-related cortices. We hypothesized that this weaker dynamic pathway is due to a subtle trigger challenging the cognitive state prior to the resting state.

  5. Dispersion entropy for the analysis of resting-state MEG regularity in Alzheimer's disease.

    Science.gov (United States)

    Azami, Hamed; Rostaghi, Mostafa; Fernandez, Alberto; Escudero, Javier

    2016-08-01

    Alzheimer's disease (AD) is a progressive degenerative brain disorder affecting memory, thinking, behaviour and emotion. It is the most common form of dementia and a big social problem in western societies. The analysis of brain activity may help to diagnose this disease. Changes in entropy methods have been reported useful in research studies to characterize AD. We have recently proposed dispersion entropy (DisEn) as a very fast and powerful tool to quantify the irregularity of time series. The aim of this paper is to evaluate the ability of DisEn, in comparison with fuzzy entropy (FuzEn), sample entropy (SampEn), and permutation entropy (PerEn), to discriminate 36 AD patients from 26 elderly control subjects using resting-state magnetoencephalogram (MEG) signals. The results obtained by DisEn, FuzEn, and SampEn, unlike PerEn, show that the AD patients' signals are more regular than controls' time series. The p-values obtained by DisEn, FuzEn, SampEn, and PerEn based methods demonstrate the superiority of DisEn over PerEn, SampEn, and PerEn. Moreover, the computation time for the newly proposed DisEn-based method is noticeably less than for the FuzEn, SampEn, and PerEn based approaches.

  6. ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW

    NARCIS (Netherlands)

    Koch, Saskia B. J.; van Zuiden, Mirjam; Nawijn, Laura; Frijling, Jessie L.; Veltman, Dick J.; Olff, Miranda

    2016-01-01

    About 10% of trauma-exposed individuals develop PTSD. Although a growing number of studies have investigated resting-state abnormalities in PTSD, inconsistent results suggest a need for a meta-analysis and a systematic review. We conducted a systematic literature search in four online databases

  7. Generalized ward identities for non-local transformation

    International Nuclear Information System (INIS)

    Li Ziping; Li Ruijie

    2002-01-01

    Based on the phase-space generating functional of Green function for a system with a singular higher-order Lagrangian, the generalized canonical Ward identities under the local and non-local transformation in phase space for such a system have been derived. Starting from the configuration-space generating functional for a gauge-invariant system, the generalized Ward identities were deduced under the local, non-local and global transformation, respectively. The applications to the non-Abelian Chern-Simons theories with higher derivatives were given. Some relationships among the proper vertices have been deduced, in which one does not need to carry out the integration over canonical momenta in phase-space generating functional. The Ward-Takahashi identities for BRS transformation are also obtained

  8. On non local elasticity and its relation with lattice dynamics

    International Nuclear Information System (INIS)

    Idiodi, J.O.A.

    1984-11-01

    In this paper we have modelled a three-dimensional discrete lattice by a nonlocal continuum which possesses dispersive phonons. Previous efforts in the development of non-local theories appear not to have paid much attention to establishing actual contact with the nontrivial models frequently employed in lattice dynamics. As a first attempt in this direction, we present in this paper explicit results for the form of a non-local stress-tensor that describes exactly the lattice dynamical model of Gazis, Herman and Wallis. This model takes into account angular stiffness forces involving consecutive nearest neighbours forming a right angle at equilibrium. In addition, a general result for the surface eigenmodes of a semi-finite isotropic medium is derived. One of the justifications for this kind of study is the simpler approach it offers to the problems of interest in lattice dynamics. (author)

  9. Cosmological perturbations in non-local higher-derivative gravity

    International Nuclear Information System (INIS)

    Craps, Ben; Jonckheere, Tim De; Koshelev, Alexey S.

    2014-01-01

    We study cosmological perturbations in a non-local higher-derivative model of gravity introduced by Biswas, Mazumdar and Siegel. We extend previous work, which had focused on classical scalar perturbations around a cosine hyperbolic bounce solution, in three ways. First, we point out the existence of a Starobinsky solution in this model, which is more attractive from a phenomenological point of view (even though it has no bounce). Second, we study classical vector and tensor pertuxsxrbations. Third, we show how to quantize scalar and tensor perturbations in a de Sitter phase (for choices of parameters such that the model is ghost-free). Our results show that the model is well-behaved at this level, and are very similar to corresponding results in local f(R) models. In particular, for the Starobinsky solution of non-local higher-derivative gravity, we find the same tensor-to-scalar ratio as for the conventional Starobinsky model

  10. Hurst Exponent Analysis of Resting-State fMRI Signal Complexity across the Adult Lifespan

    Directory of Open Access Journals (Sweden)

    Jianxin Dong

    2018-02-01

    Full Text Available Exploring functional information among various brain regions across time enables understanding of healthy aging process and holds great promise for age-related brain disease diagnosis. This paper proposed a method to explore fractal complexity of the resting-state functional magnetic resonance imaging (rs-fMRI signal in the human brain across the adult lifespan using Hurst exponent (HE. We took advantage of the examined rs-fMRI data from 116 adults 19 to 85 years of age (44.3 ± 19.4 years, 49 females from NKI/Rockland sample. Region-wise and voxel-wise analyses were performed to investigate the effects of age, gender, and their interaction on complexity. In region-wise analysis, we found that the healthy aging is accompanied by a loss of complexity in frontal and parietal lobe and increased complexity in insula, limbic, and temporal lobe. Meanwhile, differences in HE between genders were found to be significant in parietal lobe (p = 0.04, corrected. However, there was no interaction between gender and age. In voxel-wise analysis, the significant complexity decrease with aging was found in frontal and parietal lobe, and complexity increase was found in insula, limbic lobe, occipital lobe, and temporal lobe with aging. Meanwhile, differences in HE between genders were found to be significant in frontal, parietal, and limbic lobe. Furthermore, we found age and sex interaction in right parahippocampal gyrus (p = 0.04, corrected. Our findings reveal HE variations of the rs-fMRI signal across the human adult lifespan and show that HE may serve as a new parameter to assess healthy aging process.

  11. Multiple-Trace Operators and Non-Local String Theories

    International Nuclear Information System (INIS)

    Silverstein, Eva M.

    2001-01-01

    We propose that a novel deformation of string perturbation theory, involving non-local interactions between strings, is required to describe the gravity duals of field theories deformed by multiple-trace operators. The new perturbative expansion involves a new parameter, which is neither the string coupling nor the coefficient of a vertex operator on the worldsheet. We explore some of the properties of this deformation, focusing on a special case where the deformation in the field theory is exactly marginal

  12. Ground state solutions for non-local fractional Schrodinger equations

    Directory of Open Access Journals (Sweden)

    Yang Pu

    2015-08-01

    Full Text Available In this article, we study a time-independent fractional Schrodinger equation with non-local (regional diffusion $$ (-\\Delta^{\\alpha}_{\\rho}u + V(xu = f(x,u \\quad \\text{in }\\mathbb{R}^{N}, $$ where $\\alpha \\in (0,1$, $N > 2\\alpha$. We establish the existence of a non-negative ground state solution by variational methods.

  13. Non-local deformation of a supersymmetric field theory

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Qin [National University of Singapore, Department of Physics, Singapore (Singapore); Faizal, Mir [University of Lethbridge, Department of Physics and Astronomy, Lethbridge (Canada); University of British Columbia - Okanagan, Irving K. Barber School of Arts and Sciences, Kelowna, BC (Canada); Shah, Mushtaq B.; Ganai, Prince A. [National Institute of Technology, Department of Physics, Srinagar, Kashmir (India); Bhat, Anha [National Institute of Technology, Department of Metallurgical and Materials Engineering, Srinagar (India); Zaz, Zaid [University of Kashmir, Department of Electronics and Communication Engineering, Srinagar, Kashmir (India); Masood, Syed; Raza, Jamil; Irfan, Raja Muhammad [International Islamic University, Department of Physics, Islamabad (Pakistan)

    2017-09-15

    In this paper, we will analyze a supersymmetric field theory deformed by generalized uncertainty principle and Lifshitz scaling. It will be observed that this deformed supersymmetric field theory contains non-local fractional derivative terms. In order to construct such a deformed N = 1 supersymmetric theory, a harmonic extension of functions will be used. However, the supersymmetry will only be preserved for a free theory and will be broken by the inclusion of interaction terms. (orig.)

  14. Non-local gravity with a Weyl-square term

    CERN Document Server

    Cusin, Giulia; Maggiore, Michele; Mancarella, Michele

    2016-01-01

    Recent work has shown that modifications of General Relativity based on the addition of a non-local term $R\\,\\Box^{-2}R$ produce a dynamical model of dark energy, which is cosmologically viable both at the background level and at the level of cosmological perturbations. We explore a more general class of models based on the addition of terms proportional to $R_{\\mu\

  15. Critical thresholds in flocking hydrodynamics with non-local alignment.

    Science.gov (United States)

    Tadmor, Eitan; Tan, Changhui

    2014-11-13

    We study the large-time behaviour of Eulerian systems augmented with non-local alignment. Such systems arise as hydrodynamic descriptions of agent-based models for self-organized dynamics, e.g. Cucker & Smale (2007 IEEE Trans. Autom. Control 52, 852-862. (doi:10.1109/TAC.2007.895842)) and Motsch & Tadmor (2011 J. Stat. Phys. 144, 923-947. (doi:10.1007/s10955-011-0285-9)) models. We prove that, in analogy with the agent-based models, the presence of non-local alignment enforces strong solutions to self-organize into a macroscopic flock. This then raises the question of existence of such strong solutions. We address this question in one- and two-dimensional set-ups, proving global regularity for subcritical initial data. Indeed, we show that there exist critical thresholds in the phase space of the initial configuration which dictate the global regularity versus a finite-time blow-up. In particular, we explore the regularity of non-local alignment in the presence of vacuum. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  16. Is Rest Really Rest? Resting State Functional Connectivity during Rest and Motor Task Paradigms.

    Science.gov (United States)

    Jurkiewicz, Michael T; Crawley, Adrian P; Mikulis, David J

    2018-04-18

    Numerous studies have identified the default mode network (DMN) within the brain of healthy individuals, which has been attributed to the ongoing mental activity of the brain during the wakeful resting-state. While engaged during specific resting-state fMRI paradigms, it remains unclear as to whether traditional block-design simple movement fMRI experiments significantly influence the default mode network or other areas. Using blood-oxygen level dependent (BOLD) fMRI we characterized the pattern of functional connectivity in healthy subjects during a resting-state paradigm and compared this to the same resting-state analysis performed on motor task data residual time courses after regressing out the task paradigm. Using seed-voxel analysis to define the DMN, the executive control network (ECN), and sensorimotor, auditory and visual networks, the resting-state analysis of the residual time courses demonstrated reduced functional connectivity in the motor network and reduced connectivity between the insula and the ECN compared to the standard resting-state datasets. Overall, performance of simple self-directed motor tasks does little to change the resting-state functional connectivity across the brain, especially in non-motor areas. This would suggest that previously acquired fMRI studies incorporating simple block-design motor tasks could be mined retrospectively for assessment of the resting-state connectivity.

  17. Resting Orientations of Dinosaur Scapulae and Forelimbs: A Numerical Analysis, with Implications for Reconstructions and Museum Mounts.

    Science.gov (United States)

    Senter, Phil; Robins, James H

    2015-01-01

    The inclination of the scapular blade and the resting pose of the forelimb in dinosaurs differ among reconstructions and among skeletal mounts. For most dinosaurian taxa, no attempt has previously been made to quantify the correct resting positions of these elements. Here, we used data from skeletons preserved in articulation to quantify the resting orientations of the scapula and forelimb in dinosaurs. Specimens were included in the study only if they were preserved lying on their sides; for each specimen the angle between forelimb bones at a given joint was included in the analysis only if the joint was preserved in articulation. Using correlation analyses of the angles between the long axis of the sacrum, the first dorsal centrum, and the scapular blade in theropods and Eoraptor, we found that vertebral hyperextension does not influence scapular orientation in saurischians. Among examined taxa, the long axis of the scapular blade was found to be most horizontal in bipedal saurischians, most vertical in basal ornithopods, and intermediate in hadrosauroids. We found that in bipedal dinosaurs other than theropods with semilunate carpals, the resting orientation of the elbow is close to a right angle and the resting orientation of the wrist is such that the hand exhibits only slight ulnar deviation from the antebrachium. In theropods with semilunate carpals the elbow and wrist are more flexed at rest, with the elbow at a strongly acute angle and with the wrist approximately at a right angle. The results of our study have important implications for correct orientations of bones in reconstructions and skeletal mounts. Here, we provide recommendations on bone orientations based on our results.

  18. Application of the Modified Vlasov Model to the Free Vibration Analysis of Thick Plates Resting on Elastic Foundations

    OpenAIRE

    Ozgan, Korhan; Daloglu, Ayse T.

    2009-01-01

    The Modified Vlasov Model is applied to the free vibration analysis of thick plates resting on elastic foundations. The effects of the subsoil depth, plate dimensions and their ratio, the value of the vertical deformation parameter within the subsoil on the frequency parameters of plates on elastic foundations are investigated. A four-noded, twelve degrees of freedom quadrilateral finite element (PBQ4) is used for plate bending analysis based on Mindlin plate theory which is effectively appli...

  19. Resting State EEG in Children With Learning Disabilities: An Independent Component Analysis Approach.

    Science.gov (United States)

    Jäncke, Lutz; Alahmadi, Nsreen

    2016-01-01

    In this study, the neurophysiological underpinnings of learning disabilities (LD) in children are examined using resting state EEG. We were particularly interested in the neurophysiological differences between children with learning disabilities not otherwise specified (LD-NOS), learning disabilities with verbal disabilities (LD-Verbal), and healthy control (HC) children. We applied 2 different approaches to examine the differences between the different groups. First, we calculated theta/beta and theta/alpha ratios in order to quantify the relationship between slow and fast EEG oscillations. Second, we used a recently developed method for analyzing spectral EEG, namely the group independent component analysis (gICA) model. Using these measures, we identified substantial differences between LD and HC children and between LD-NOS and LD-Verbal children in terms of their spectral EEG profiles. We obtained the following findings: (a) theta/beta and theta/alpha ratios were substantially larger in LD than in HC children, with no difference between LD-NOS and LD-Verbal children; (b) there was substantial slowing of EEG oscillations, especially for gICs located in frontal scalp positions, with LD-NOS children demonstrating the strongest slowing; (c) the estimated intracortical sources of these gICs were mostly located in brain areas involved in the control of executive functions, attention, planning, and language; and (d) the LD-Verbal children demonstrated substantial differences in EEG oscillations compared with LD-NOS children, and these differences were localized in language-related brain areas. The general pattern of atypical neurophysiological activation found in LD children suggests that they suffer from neurophysiological dysfunction in brain areas involved with the control of attention, executive functions, planning, and language functions. LD-Verbal children also demonstrate atypical activation, especially in language-related brain areas. These atypical

  20. A space-jump derivation for non-local models of cell-cell adhesion and non-local chemotaxis.

    Science.gov (United States)

    Buttenschön, Andreas; Hillen, Thomas; Gerisch, Alf; Painter, Kevin J

    2018-01-01

    Cellular adhesion provides one of the fundamental forms of biological interaction between cells and their surroundings, yet the continuum modelling of cellular adhesion has remained mathematically challenging. In 2006, Armstrong et al. proposed a mathematical model in the form of an integro-partial differential equation. Although successful in applications, a derivation from an underlying stochastic random walk has remained elusive. In this work we develop a framework by which non-local models can be derived from a space-jump process. We show how the notions of motility and a cell polarization vector can be naturally included. With this derivation we are able to include microscopic biological properties into the model. We show that particular choices yield the original Armstrong model, while others lead to more general models, including a doubly non-local adhesion model and non-local chemotaxis models. Finally, we use random walk simulations to confirm that the corresponding continuum model represents the mean field behaviour of the stochastic random walk.

  1. Evaluating the optimum rest period prior to blood collection for fractionated plasma free metanephrines analysis

    LENUS (Irish Health Repository)

    Griffin, T.P.

    2016-05-01

    The high diagnostic accuracy of plasma metanephrines (PMets) in the di-agnosis of Phaeochromocytoma\\/Paraganglioma (PPGL) is well established. Considerable controversy exists regarding optimum sampling conditions for PMets. The use of reference intervals that do not compromise diagnostic sensitivity is recommended. However, the optimum rest period prior to sampling has yet to be clearly established. The aim of this study was to evaluate PMets concentrations in paired blood samples collected following 30 and 40 min seated-rest prior to sampling, in patients in whom it was clinically rea-sonable to suspect that PPGL may be present.

  2. Continuous analysis of parotid saliva during resting and short-duration simulated chewing

    NARCIS (Netherlands)

    Neyraud, E.; Bult, J.H.F.; Dransfield, E.

    2009-01-01

    Objective: Parotid saliva flow is increased by mastication and its composition is also modified. The aim of this work was to clarify the relationships between flow rate, pH and protein concentration, during resting and short-duration simulated chewing, using continuous and fractional saliva

  3. Complexity Analysis of Resting-State MEG Activity in Early-Stage Parkinson's Disease Patients

    NARCIS (Netherlands)

    Gómez, C.; Olde Dubbelink, K.T.E.; Stam, C.J.; Abasolo, D.; Berendse, H.W.; Hornero, R.

    2011-01-01

    The aim of the present study was to analyze resting-state brain activity in patients with Parkinson's disease (PD), a degenerative disorder of the nervous system. Magnetoencephalography (MEG) signals were recorded with a 151-channel whole-head radial gradiometer MEG system in 18 early-stage

  4. Whole brain resting-state analysis reveals decreased functional connectivity in major depression

    NARCIS (Netherlands)

    Veer, I.M.; Beckmann, C.F.; van Tol, M.J.; Ferrarini, L.; Milles, J.; Veltman, D.J.; Aleman, A.; van Buchem, M.A.; van der Wee, N.J.; Rombouts, S.A.R.B.

    2010-01-01

    Recently, both increases and decreases in resting-state functional connectivity have been found in major depression. However, these studies only assessed functional connectivity within a specific network or between a few regions of interest, while comorbidity and use of medication was not always

  5. Multiscale entropy analysis of resting-state magnetoencephalogram with tensor factorisations in Alzheimer's disease

    DEFF Research Database (Denmark)

    Escudero, Javier; Evrim, Acar Ataman; Fernández, Alberto

    2015-01-01

    dynamics. We consider the "refined composite multiscale entropy" (rcMSE), which computes entropy "profiles" showing levels of physiological complexity over temporal scales for individual signals. We compute the rcMSE of resting-state magnetoencephalogram (MEG) recordings from 36 patients with Alzheimer...

  6. Bed rest versus early ambulation with standard anticoagulation in the management of deep vein thrombosis: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Zhenlei Liu

    Full Text Available Bed rest has been considered as the cornerstone of management of deep vein thrombosis (DVT for a long time, though it is not evidence-base, and there is growing evidence favoring early ambulation.Electronic databases including Medline, PubMed, Cochrane Library and three Chinese databases were searched with key words of "deep vein thrombosis", "pulmonary embolism", "venous thrombosis", "bed rest", "immobilization", "mobilization" and "ambulation". We considered randomized controlled trials, prospective or retrospective cohort studies that compared the outcomes of acute DVT patients managed with early ambulation versus bed rest, in addition to standard anticoagulation. Meta-analysis pertaining to the incidence of new pulmonary embolism (PE, progression of DVT, and DVT related deaths were conducted, as well as the extent of remission of pain and edema.13 studies were included with a total of 3269 patients. Compared to bed rest, early ambulation was not associated with a higher incidence of new PE, progression of DVT, or DVT related deaths (RD -0.03, 95% CI -0.05∼ -0.02; Z = 1.24, p = 0.22; random effect model, Tau2 = 0.01. Moreover, if the patients suffered moderate or severe pain initially, early ambulation was related to a better outcome, with respect to remission of acute pain in the affected limb (SMD 0.42, 95%CI 0.09∼0.74; Z = 2.52, p = 0.01; random effect model, Tau2 = 0.04. Meta-analysis of alleviation of edema cannot elicit a solid conclusion because of significant heterogeneity among the few studies.Compared to bed rest, early ambulation of acute DVT patients with anticoagulation was not associated with a higher incidence of new PE, progression of DVT, and DVT related deaths. Furthermore, for the patients suffered moderate or severe pain initially, a better outcome can be seen in early ambulation group, regarding to the remission of acute pain in the affected limb.

  7. Towards a test of non-locality without 'supplementary assumptions'

    International Nuclear Information System (INIS)

    Barbieri, M.; De Martini, F.; Di Nepi, G.; Mataloni, P.

    2005-01-01

    We have experimentally tested the non-local properties of the two-photon states generated by a high brilliance source of entanglement which virtually allows the direct measurement of the full set of photon pairs created by the basic QED process implied by the parametric quantum scattering. Standard Bell measurements and Bell's inequality violation test have been realized over the entire cone of emission of the degenerate pairs. By the same source we have verified Hardy's ladder theory up to the 20th step and the contradiction between the standard quantum theory and the local realism has been tested for 41% of entangled pairs

  8. Non-local quasi-linear parabolic equations

    International Nuclear Information System (INIS)

    Amann, H

    2005-01-01

    This is a survey of the most common approaches to quasi-linear parabolic evolution equations, a discussion of their advantages and drawbacks, and a presentation of an entirely new approach based on maximal L p regularity. The general results here apply, above all, to parabolic initial-boundary value problems that are non-local in time. This is illustrated by indicating their relevance for quasi-linear parabolic equations with memory and, in particular, for time-regularized versions of the Perona-Malik equation of image processing

  9. Resting-State Functional Connectivity and Network Analysis of Cerebellum with Respect to IQ and Gender

    Directory of Open Access Journals (Sweden)

    Vasileios C. Pezoulas

    2017-04-01

    Full Text Available During the last years, it has been established that the prefrontal and posterior parietal brain lobes, which are mostly related to intelligence, have many connections to cerebellum. However, there is a limited research investigating cerebellum's relationship with cognitive processes. In this study, the network of cerebellum was analyzed in order to investigate its overall organization in individuals with low and high fluid Intelligence Quotient (IQ. Functional magnetic resonance imaging (fMRI data were selected from 136 subjects in resting-state from the Human Connectome Project (HCP database and were further separated into two IQ groups composed of 69 low-IQ and 67 high-IQ subjects. Cerebellum was parcellated into 28 lobules/ROIs (per subject using a standard cerebellum anatomical atlas. Thereafter, correlation matrices were constructed by computing Pearson's correlation coefficients between the average BOLD time-series for each pair of ROIs inside the cerebellum. By computing conventional graph metrics, small-world network properties were verified using the weighted clustering coefficient and the characteristic path length for estimating the trade-off between segregation and integration. In addition, a connectivity metric was computed for extracting the average cost per network. The concept of the Minimum Spanning Tree (MST was adopted and implemented in order to avoid methodological biases in graph comparisons and retain only the strongest connections per network. Subsequently, six global and three local metrics were calculated in order to retrieve useful features concerning the characteristics of each MST. Moreover, the local metrics of degree and betweenness centrality were used to detect hubs, i.e., nodes with high importance. The computed set of metrics gave rise to extensive statistical analysis in order to examine differences between low and high-IQ groups, as well as between all possible gender-based group combinations. Our results

  10. A non-local computational boundary condition for duct acoustics

    Science.gov (United States)

    Zorumski, William E.; Watson, Willie R.; Hodge, Steve L.

    1994-01-01

    A non-local boundary condition is formulated for acoustic waves in ducts without flow. The ducts are two dimensional with constant area, but with variable impedance wall lining. Extension of the formulation to three dimensional and variable area ducts is straightforward in principle, but requires significantly more computation. The boundary condition simulates a nonreflecting wave field in an infinite duct. It is implemented by a constant matrix operator which is applied at the boundary of the computational domain. An efficient computational solution scheme is developed which allows calculations for high frequencies and long duct lengths. This computational solution utilizes the boundary condition to limit the computational space while preserving the radiation boundary condition. The boundary condition is tested for several sources. It is demonstrated that the boundary condition can be applied close to the sound sources, rendering the computational domain small. Computational solutions with the new non-local boundary condition are shown to be consistent with the known solutions for nonreflecting wavefields in an infinite uniform duct.

  11. Gauge unification, non-local breaking, open strings

    International Nuclear Information System (INIS)

    Trapletti, M.

    2005-01-01

    The issue of non-local GUT symmetry breaking is addressed in the context of open string model building. We study Z N xZ M ' orbifolds with all the GUT-breaking orbifold elements acting freely, as rotations accompanied by translations in the internal space. We consider open strings quantized on these backgrounds, distinguishing whether the translational action is parallel or perpendicular to the D-branes. GUT breaking is impossible in the purely perpendicular case, non-local GUT breaking is instead allowed in the purely parallel case. In the latter, the scale of breaking is set by the compactification moduli, and there are no fixed points with reduced gauge symmetry, where dangerous explicit GUT-breaking terms could be located. We investigate the mixed parallel+perpendicular case in a Z 2 xZ 2 ' example, having also a simplified field theory realization. It is a new S 1 /Z 2 xZ 2 ' orbifold-GUT model, with bulk gauge symmetry SU(5)xSU(5) broken locally to the Standard Model gauge group. In spite of the locality of the GUT symmetry breaking, there is no localized contribution to the running of the coupling constants, and the unification scale is completely set by the length of S 1

  12. OCT despeckling via weighted nuclear norm constrained non-local low-rank representation

    Science.gov (United States)

    Tang, Chang; Zheng, Xiao; Cao, Lijuan

    2017-10-01

    As a non-invasive imaging modality, optical coherence tomography (OCT) plays an important role in medical sciences. However, OCT images are always corrupted by speckle noise, which can mask image features and pose significant challenges for medical analysis. In this work, we propose an OCT despeckling method by using non-local, low-rank representation with weighted nuclear norm constraint. Unlike previous non-local low-rank representation based OCT despeckling methods, we first generate a guidance image to improve the non-local group patches selection quality, then a low-rank optimization model with a weighted nuclear norm constraint is formulated to process the selected group patches. The corrupted probability of each pixel is also integrated into the model as a weight to regularize the representation error term. Note that each single patch might belong to several groups, hence different estimates of each patch are aggregated to obtain its final despeckled result. Both qualitative and quantitative experimental results on real OCT images show the superior performance of the proposed method compared with other state-of-the-art speckle removal techniques.

  13. STABLE STATIONARY STATES OF NON-LOCAL INTERACTION EQUATIONS

    KAUST Repository

    FELLNER, KLEMENS

    2010-12-01

    In this paper, we are interested in the large-time behaviour of a solution to a non-local interaction equation, where a density of particles/individuals evolves subject to an interaction potential and an external potential. It is known that for regular interaction potentials, stable stationary states of these equations are generically finite sums of Dirac masses. For a finite sum of Dirac masses, we give (i) a condition to be a stationary state, (ii) two necessary conditions of linear stability w.r.t. shifts and reallocations of individual Dirac masses, and (iii) show that these linear stability conditions imply local non-linear stability. Finally, we show that for regular repulsive interaction potential Wε converging to a singular repulsive interaction potential W, the Dirac-type stationary states ρ̄ ε approximate weakly a unique stationary state ρ̄ ∈ L∞. We illustrate our results with numerical examples. © 2010 World Scientific Publishing Company.

  14. Sign-changing solutions for non-local elliptic equations

    Directory of Open Access Journals (Sweden)

    Huxiao Luo

    2017-07-01

    Full Text Available This article concerns the existence of sign-changing solutions for equations driven by a non-local integrodifferential operator with homogeneous Dirichlet boundary conditions, $$\\displaylines{ -\\mathcal{L}_Ku=f(x,u,\\quad x\\in \\Omega, \\cr u=0,\\quad x\\in \\mathbb{R}^n\\setminus\\Omega, }$$ where $\\Omega\\subset\\mathbb{R}^n\\; (n\\geq2$ is a bounded, smooth domain and the nonlinear term f satisfies suitable growth assumptions. By using Brouwer's degree theory and Deformation Lemma and arguing as in [2], we prove that there exists a least energy sign-changing solution. Our results generalize and improve some results obtained in [27

  15. Inflationary magnetogenesis and non-local actions: the conformal anomaly

    Energy Technology Data Exchange (ETDEWEB)

    El-Menoufi, Basem Kamal, E-mail: bmahmoud@physics.umass.edu [Department of Physics, University of Massachusetts Amherst, MA 01003 (United States)

    2016-02-01

    We discuss the possibility of successful magnetogenesis during inflation by employing the one-loop effective action of massless QED. The action is strictly non-local and results from the long distance fluctuations of massless charged particles present at the inflationary scale. Most importantly, it encodes the conformal anomaly of QED which is crucial to avoid the vacuum preservation in classical electromagnetism. In particular, we find a blue spectrum for the magnetic field with spectral index n{sub B} ≅ 2 − α{sub e} where α{sub e} depends on both the number of e-folds during inflation as well as the coefficient of the one-loop beta function. In particular, the sign of the beta function has important bearing on the final result. A low reheating temperature is required for the present day magnetic field to be consistent with the lower bound inferred on the field in the intergalactic medium.

  16. Quantum gravitational collapse: non-singularity and non-locality

    International Nuclear Information System (INIS)

    Greenwood, Eric; Stojkovic, Dejan

    2008-01-01

    We investigate gravitational collapse in the context of quantum mechanics. We take primary interest in the behavior of the collapse near the horizon and near the origin (classical singularity) from the point of view of an infalling observer. In the absence of radiation, quantum effects near the horizon do not change the classical conclusions for an infalling observer, meaning the horizon is not an obstacle for him. However, quantum effects are able to remove the classical singularity at the origin, since the wave function is non-singular at the origin. Also, near the classical singularity, some non-local effects become important. In the Schrodinger equation describing behavior near the origin, derivatives of the wave function at one point are related to the value of the wave function at some other distant point.

  17. Non-local means filter for trim statics

    KAUST Repository

    Huang, Yunsong

    2014-08-05

    Structures will be mispositioned across prestack migration gathers in the presence of inaccuracies in the velocity model. Stacking these misaligned gathers runs the risk of destroying important structures in the stacked migration image. To mitigate this problem, we propose a trim statics inspired by the non-local means algorithm originally developed for image denoising. This method differs from the conventional one in two fundamental respects. First, the trim statics are computed by comparing image patches instead of individual image traces. Second, no global pilot trace is needed because only two migration images at a time participate in trim statics and are stacked into one image. A multitude of migration images are stacked recursively in this two-to-one fashion. Tests with a Gulf of Mexico dataset show a noticeable improvement in the feature coherency of the stacked migration image.

  18. Age-Related Decline in the Variation of Dynamic Functional Connectivity: A Resting State Analysis

    Directory of Open Access Journals (Sweden)

    Yuanyuan Chen

    2017-06-01

    Full Text Available Normal aging is typically characterized by abnormal resting-state functional connectivity (FC, including decreasing connectivity within networks and increasing connectivity between networks, under the assumption that the FC over the scan time was stationary. In fact, the resting-state FC has been shown in recent years to vary over time even within minutes, thus showing the great potential of intrinsic interactions and organization of the brain. In this article, we assumed that the dynamic FC consisted of an intrinsic dynamic balance in the resting brain and was altered with increasing age. Two groups of individuals (N = 36, ages 20–25 for the young group; N = 32, ages 60–85 for the senior group were recruited from the public data of the Nathan Kline Institute. Phase randomization was first used to examine the reliability of the dynamic FC. Next, the variation in the dynamic FC and the energy ratio of the dynamic FC fluctuations within a higher frequency band were calculated and further checked for differences between groups by non-parametric permutation tests. The results robustly showed modularization of the dynamic FC variation, which declined with aging; moreover, the FC variation of the inter-network connections, which mainly consisted of the frontal-parietal network-associated and occipital-associated connections, decreased. In addition, a higher energy ratio in the higher FC fluctuation frequency band was observed in the senior group, which indicated the frequency interactions in the FC fluctuations. These results highly supported the basis of abnormality and compensation in the aging brain and might provide new insights into both aging and relevant compensatory mechanisms.

  19. Graph-based network analysis of resting-state functional MRI

    Directory of Open Access Journals (Sweden)

    Jinhui Wang

    2010-06-01

    Full Text Available In the past decade, resting-state functional MRI (R-fMRI measures of brain activity have attracted considerable attention. Based on changes in the blood oxygen level-dependent signal, R-fMRI offers a novel way to assess the brain’s spontaneous or intrinsic (i.e., task-free activity with both high spatial and temporal resolutions. The properties of both the intra- and inter-regional connectivity of resting-state brain activity have been well documented, promoting our understanding of the brain as a complex network. Specifically, the topological organization of brain networks has been recently studied with graph theory. In this review, we will summarize the recent advances in graph-based brain network analyses of R-fMRI signals, both in typical and atypical populations. Application of these approaches to R-fMRI data has demonstrated non-trivial topological properties of functional networks in the human brain. Among these is the knowledge that the brain’s intrinsic activity is organized as a small-world, highly efficient network, with significant modularity and highly connected hub regions. These network properties have also been found to change throughout normal development, aging and in various pathological conditions. The literature reviewed here suggests that graph-based network analyses are capable of uncovering system-level changes associated with different processes in the resting brain, which could provide novel insights into the understanding of the underlying physiological mechanisms of brain function. We also highlight several potential research topics in the future.

  20. Graph-based network analysis of resting-state functional MRI.

    Science.gov (United States)

    Wang, Jinhui; Zuo, Xinian; He, Yong

    2010-01-01

    In the past decade, resting-state functional MRI (R-fMRI) measures of brain activity have attracted considerable attention. Based on changes in the blood oxygen level-dependent signal, R-fMRI offers a novel way to assess the brain's spontaneous or intrinsic (i.e., task-free) activity with both high spatial and temporal resolutions. The properties of both the intra- and inter-regional connectivity of resting-state brain activity have been well documented, promoting our understanding of the brain as a complex network. Specifically, the topological organization of brain networks has been recently studied with graph theory. In this review, we will summarize the recent advances in graph-based brain network analyses of R-fMRI signals, both in typical and atypical populations. Application of these approaches to R-fMRI data has demonstrated non-trivial topological properties of functional networks in the human brain. Among these is the knowledge that the brain's intrinsic activity is organized as a small-world, highly efficient network, with significant modularity and highly connected hub regions. These network properties have also been found to change throughout normal development, aging, and in various pathological conditions. The literature reviewed here suggests that graph-based network analyses are capable of uncovering system-level changes associated with different processes in the resting brain, which could provide novel insights into the understanding of the underlying physiological mechanisms of brain function. We also highlight several potential research topics in the future.

  1. Buckling Analysis of Rectangular Plates with Variable Thickness Resting on Elastic Foundation

    International Nuclear Information System (INIS)

    Viswanathan, K K; Aziz, Z A; Navaneethakrishnan, P V

    2015-01-01

    Buckling of rectangular plates of variable thickness resting in elastic foundation is analysed using a quintic spline approximation technique. The thickness of the plate varies in the direction of one edge and the variations are assumed to be linear, exponential and sinusoidal. The plate is subjected to in plane load of two opposite edges. The buckling load and the mode shapes of buckling are computed from the eigenvalue problem that arises. Detailed parametric studies are made with different boundary conditions and the results are presented through the diagram and discussed

  2. Machine Learning Applications to Resting-State Functional MR Imaging Analysis.

    Science.gov (United States)

    Billings, John M; Eder, Maxwell; Flood, William C; Dhami, Devendra Singh; Natarajan, Sriraam; Whitlow, Christopher T

    2017-11-01

    Machine learning is one of the most exciting and rapidly expanding fields within computer science. Academic and commercial research entities are investing in machine learning methods, especially in personalized medicine via patient-level classification. There is great promise that machine learning methods combined with resting state functional MR imaging will aid in diagnosis of disease and guide potential treatment for conditions thought to be impossible to identify based on imaging alone, such as psychiatric disorders. We discuss machine learning methods and explore recent advances. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Non-local matrix generalizations of W-algebras

    International Nuclear Information System (INIS)

    Bilal, A.

    1995-01-01

    There is a standard way to define two symplectic (hamiltonian) structures, the first and second Gelfand-Dikii brackets, on the space of ordinary m th -order linear differential operators L=-d m +U 1 d m-1 +U 2 d m-2 +..+U m . In this paper, I consider in detail the case where the U k are nxn-matrix-valued functions, with particular emphasis on the (more interesting) second Gelfand-Dikii bracket. Of particular interest is the reduction to the symplectic submanifold U 1 =0. This reduction gives rise to matrix generalizations of (the classical version of) the non-linear W m -algebras, called V n,m -algebras. The non-commutativity of the matrices leads to non-local terms in these V n,m -algebras. I show that these algebras contain a conformal Virasoro subalgebra and that combinations W k of the U k can be formed that are nxn-matrices of conformally primary fields of spin k, in analogy with the scalar case n=1. In general however, the V m,n -algebras have a much richer structure than the W m -algebras as can be seen on the examples of the non-linear and non-local Poisson brackets {(U 2 ) ab (σ),(U 2 ) cd (σ')}, {(U 2 ) ab (σ),(W 3 ) cd (σ')} and {(W 3 ) ab (σ),(W 3 ) cd (σ')} which I work out explicitly for all m and n. A matrix Miura transformation is derived, mapping these complicated (second Gelfand-Dikii) brackets of the U k to a set of much simpler Poisson brackets, providing the analogue of the free-field representation of the W m -algebras. (orig.)

  4. A Comprehensive Analysis of the Correlations between Resting-State Oscillations in Multiple-Frequency Bands and Big Five Traits.

    Science.gov (United States)

    Ikeda, Shigeyuki; Takeuchi, Hikaru; Taki, Yasuyuki; Nouchi, Rui; Yokoyama, Ryoichi; Kotozaki, Yuka; Nakagawa, Seishu; Sekiguchi, Atsushi; Iizuka, Kunio; Yamamoto, Yuki; Hanawa, Sugiko; Araki, Tsuyoshi; Miyauchi, Carlos Makoto; Sakaki, Kohei; Nozawa, Takayuki; Yokota, Susumu; Magistro, Daniele; Kawashima, Ryuta

    2017-01-01

    Recently, the association between human personality traits and resting-state brain activity has gained interest in neuroimaging studies. However, it remains unclear if Big Five personality traits are represented in frequency bands (~0.25 Hz) of resting-state functional magnetic resonance imaging (fMRI) activity. Based on earlier neurophysiological studies, we investigated the correlation between the five personality traits assessed by the NEO Five-Factor Inventory (NEO-FFI), and the fractional amplitude of low-frequency fluctuation (fALFF) at four distinct frequency bands (slow-5 (0.01-0.027 Hz), slow-4 (0.027-0.073 Hz), slow-3 (0.073-0.198 Hz) and slow-2 (0.198-0.25 Hz)). We enrolled 835 young subjects and calculated the correlations of resting-state fMRI signals using a multiple regression analysis. We found a significant and consistent correlation between fALFF and the personality trait of extraversion at all frequency bands. Furthermore, significant correlations were detected in distinct brain regions for each frequency band. This finding supports the frequency-specific spatial representations of personality traits as previously suggested. In conclusion, our data highlight an association between human personality traits and fALFF at four distinct frequency bands.

  5. The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF: A Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Adam Dinoff

    Full Text Available The mechanisms through which physical activity supports healthy brain function remain to be elucidated. One hypothesis suggests that increased brain-derived neurotrophic factor (BDNF mediates some cognitive and mood benefits. This meta-analysis sought to determine the effect of exercise training on resting concentrations of BDNF in peripheral blood.MEDLINE, Embase, PsycINFO, SPORTDiscus, Rehabilitation & Sports Medicine Source, and CINAHL databases were searched for original, peer-reviewed reports of peripheral blood BDNF concentrations before and after exercise interventions ≥ 2 weeks. Risk of bias was assessed using standardized criteria. Standardized mean differences (SMDs were generated from random effects models. Risk of publication bias was assessed using funnel plots and Egger's test. Potential sources of heterogeneity were explored in subgroup analyses.In 29 studies that met inclusion criteria, resting concentrations of peripheral blood BDNF were higher after intervention (SMD = 0.39, 95% CI: 0.17-0.60, p < 0.001. Subgroup analyses suggested a significant effect in aerobic (SMD = 0.66, 95% CI: 0.33-0.99, p < 0.001 but not resistance training (SMD = 0.07, 95% CI: -0.15-0.30, p = 0.52 interventions. No significant difference in effect was observed between males and females, nor in serum vs plasma.Aerobic but not resistance training interventions increased resting BDNF concentrations in peripheral blood.

  6. A Comprehensive Analysis of the Correlations between Resting-State Oscillations in Multiple-Frequency Bands and Big Five Traits

    Directory of Open Access Journals (Sweden)

    Shigeyuki Ikeda

    2017-06-01

    Full Text Available Recently, the association between human personality traits and resting-state brain activity has gained interest in neuroimaging studies. However, it remains unclear if Big Five personality traits are represented in frequency bands (~0.25 Hz of resting-state functional magnetic resonance imaging (fMRI activity. Based on earlier neurophysiological studies, we investigated the correlation between the five personality traits assessed by the NEO Five-Factor Inventory (NEO-FFI, and the fractional amplitude of low-frequency fluctuation (fALFF at four distinct frequency bands (slow-5 (0.01–0.027 Hz, slow-4 (0.027–0.073 Hz, slow-3 (0.073–0.198 Hz and slow-2 (0.198–0.25 Hz. We enrolled 835 young subjects and calculated the correlations of resting-state fMRI signals using a multiple regression analysis. We found a significant and consistent correlation between fALFF and the personality trait of extraversion at all frequency bands. Furthermore, significant correlations were detected in distinct brain regions for each frequency band. This finding supports the frequency-specific spatial representations of personality traits as previously suggested. In conclusion, our data highlight an association between human personality traits and fALFF at four distinct frequency bands.

  7. Bayesian network analysis revealed the connectivity difference of the default mode network from the resting-state to task-state

    Science.gov (United States)

    Wu, Xia; Yu, Xinyu; Yao, Li; Li, Rui

    2014-01-01

    Functional magnetic resonance imaging (fMRI) studies have converged to reveal the default mode network (DMN), a constellation of regions that display co-activation during resting-state but co-deactivation during attention-demanding tasks in the brain. Here, we employed a Bayesian network (BN) analysis method to construct a directed effective connectivity model of the DMN and compared the organizational architecture and interregional directed connections under both resting-state and task-state. The analysis results indicated that the DMN was consistently organized into two closely interacting subsystems in both resting-state and task-state. The directed connections between DMN regions, however, changed significantly from the resting-state to task-state condition. The results suggest that the DMN intrinsically maintains a relatively stable structure whether at rest or performing tasks but has different information processing mechanisms under varied states. PMID:25309414

  8. Fractional amplitude analysis of low frequency fluctuation in alcohol dependent individuals: a resting state functional MRI study

    International Nuclear Information System (INIS)

    Yan Dingfang; Cheng Jun; Wu Hanbin; Xu Liangzhou; Liu Jinhuan; Zhao Yilin; Lin Xue; Liu Changsheng; Qiu Li

    2012-01-01

    Objective: To explore brain activity features during the resting state in alcohol dependent individuals, and study the relationship between the brain activity features and alcohol dependent individuals' clinical symptoms. Methods: Twenty-four alcohol dependent individuals and 22 healthy control subjects, well matched in gender, age, education and handedness, were enrolled as the alcohol dependent group and control group respectively. A GE 3.0 T MR scanner was used to acquire all the subjects' resting state data. DPARSF software was used to process resting functional MRI data, and then the whole brain fractional amplitudes of low frequency fluctuation (fALFF) data were acquired. Two-sample t test statistical analysis was made to access fALFF difference between the two groups. Results: In comparison with the control group, the alcohol dependent group showed reduced fALFF in bilateral medial prefrontal gyrus, right inferior occipital gyrus, left precuneus,left inferior temporal gyrus, and left posterior lobe of cerebellum (0.64-1.69 vs. 0.87-1.78, t=-4.23- -2.79, P<0.05). fALFF was increased in the alcohol dependent group at the anterior cingulate,bilateral inferior frontal gyrus,right middle frontal gyrus,bilateral insular lobe,bilateral dorsal thalamus (0.86-1.82 vs. 0.76-1.58, t=3.56-3.96, P<0.05). Conclusion: Alcohol dependent individuals had abnormal activity at the bilateral prefrontal lobe,anterior cingulate, bilateral dorsal thalamus, bilateral insular lobe, left posterior lobe of cerebellum et al, during the resting state, and these abnormal activities might be related with clinical manifestation and pathophysiology. (authors)

  9. Unilateral Rolling of the Foot did not Affect Non-Local Range of Motion or Balance

    Directory of Open Access Journals (Sweden)

    Lena Grabow, James D. Young, Jeannette M. Byrne, Urs Granacher, David G. Behm

    2017-06-01

    Full Text Available Non-local or crossover (contralateral and non-stretched muscles increases in range-of-motion (ROM and balance have been reported following rolling of quadriceps, hamstrings and plantar flexors. Since there is limited information regarding plantar sole (foot rolling effects, the objectives of this study were to determine if unilateral foot rolling would affect ipsilateral and contralateral measures of ROM and balance in young healthy adults. A randomized within-subject design was used to examine non-local effects of unilateral foot rolling on ipsilateral and contralateral limb ankle dorsiflexion ROM and a modified sit-and-reach-test (SRT. Static balance was also tested during a 30 s single leg stance test. Twelve participants performed three bouts of 60 s unilateral plantar sole rolling using a roller on the dominant foot with 60 s rest intervals between sets. ROM and balance measures were assessed in separate sessions at pre-intervention, immediately and 10 minutes post-intervention. To evaluate repeated measures effects, two SRT pre-tests were implemented. Results demonstrated that the second pre-test SRT was 6.6% higher than the first pre-test (p = 0.009, d = 1.91. There were no statistically significant effects of foot rolling on any measures immediately or 10 min post-test. To conclude, unilateral foot rolling did not produce statistically significant increases in ipsilateral or contralateral dorsiflexion or SRT ROM nor did it affect postural sway. Our statistically non-significant findings might be attributed to a lower degree of roller-induced afferent stimulation due to the smaller volume of myofascia and muscle compared to prior studies. Furthermore, ROM results from studies utilizing a single pre-test without a sufficient warm-up should be viewed critically.

  10. A multi-methodological MR resting state network analysis to assess the changes in brain physiology of children with ADHD.

    Directory of Open Access Journals (Sweden)

    Benito de Celis Alonso

    Full Text Available The purpose of this work was to highlight the neurological differences between the MR resting state networks of a group of children with ADHD (pre-treatment and an age-matched healthy group. Results were obtained using different image analysis techniques. A sample of n = 46 children with ages between 6 and 12 years were included in this study (23 per cohort. Resting state image analysis was performed using ReHo, ALFF and ICA techniques. ReHo and ICA represent connectivity analyses calculated with different mathematical approaches. ALFF represents an indirect measurement of brain activity. The ReHo and ICA analyses suggested differences between the two groups, while the ALFF analysis did not. The ReHo and ALFF analyses presented differences with respect to the results previously reported in the literature. ICA analysis showed that the same resting state networks that appear in healthy volunteers of adult age were obtained for both groups. In contrast, these networks were not identical when comparing the healthy and ADHD groups. These differences affected areas for all the networks except the Right Memory Function network. All techniques employed in this study were used to monitor different cerebral regions which participate in the phenomenological characterization of ADHD patients when compared to healthy controls. Results from our three analyses indicated that the cerebellum and mid-frontal lobe bilaterally for ReHo, the executive function regions in ICA, and the precuneus, cuneus and the clacarine fissure for ALFF, were the "hubs" in which the main inter-group differences were found. These results do not just help to explain the physiology underlying the disorder but open the door to future uses of these methodologies to monitor and evaluate patients with ADHD.

  11. Vibration analysis of viscoelastic single-walled carbon nanotubes resting on a viscoelastic foundation

    International Nuclear Information System (INIS)

    Zhang, Da Peng; Lei, Yong Jun; Shen, Zhi Bin; Wang, Cheng Yuan

    2017-01-01

    Vibration responses were investigated for a viscoelastic Single-walled carbon nanotube (visco-SWCNT) resting on a viscoelastic foundation. Based on the nonlocal Euler-Bernoulli beam model, velocity-dependent external damping and Kelvin viscoelastic foundation model, the governing equations were derived. The Transfer function method (TFM) was then used to compute the natural frequencies for general boundary conditions and foundations. In particular, the exact analytical expressions of both complex natural frequencies and critical viscoelastic parameters were obtained for the Kelvin-Voigt visco-SWCNTs with full foundations and certain boundary conditions, and several physically intuitive special cases were discussed. Substantial nonlocal effects, the influence of geometric and physical parameters of the SWCNT and the viscoelastic foundation were observed for the natural frequencies of the supported SWCNTs. The study demonstrates the efficiency and robustness of the developed model for the vibration of the visco-SWCNT-viscoelastic foundation coupling system

  12. Multivariate pattern analysis strategies in detection of remitted major depressive disorder using resting state functional connectivity

    Directory of Open Access Journals (Sweden)

    Runa Bhaumik

    2017-01-01

    Full Text Available Understanding abnormal resting-state functional connectivity of distributed brain networks may aid in probing and targeting mechanisms involved in major depressive disorder (MDD. To date, few studies have used resting state functional magnetic resonance imaging (rs-fMRI to attempt to discriminate individuals with MDD from individuals without MDD, and to our knowledge no investigations have examined a remitted (r population. In this study, we examined the efficiency of support vector machine (SVM classifier to successfully discriminate rMDD individuals from healthy controls (HCs in a narrow early-adult age range. We empirically evaluated four feature selection methods including multivariate Least Absolute Shrinkage and Selection Operator (LASSO and Elastic Net feature selection algorithms. Our results showed that SVM classification with Elastic Net feature selection achieved the highest classification accuracy of 76.1% (sensitivity of 81.5% and specificity of 68.9% by leave-one-out cross-validation across subjects from a dataset consisting of 38 rMDD individuals and 29 healthy controls. The highest discriminating functional connections were between the left amygdala, left posterior cingulate cortex, bilateral dorso-lateral prefrontal cortex, and right ventral striatum. These appear to be key nodes in the etiopathophysiology of MDD, within and between default mode, salience and cognitive control networks. This technique demonstrates early promise for using rs-fMRI connectivity as a putative neurobiological marker capable of distinguishing between individuals with and without rMDD. These methods may be extended to periods of risk prior to illness onset, thereby allowing for earlier diagnosis, prevention, and intervention.

  13. Multivariate pattern analysis strategies in detection of remitted major depressive disorder using resting state functional connectivity.

    Science.gov (United States)

    Bhaumik, Runa; Jenkins, Lisanne M; Gowins, Jennifer R; Jacobs, Rachel H; Barba, Alyssa; Bhaumik, Dulal K; Langenecker, Scott A

    2017-01-01

    Understanding abnormal resting-state functional connectivity of distributed brain networks may aid in probing and targeting mechanisms involved in major depressive disorder (MDD). To date, few studies have used resting state functional magnetic resonance imaging (rs-fMRI) to attempt to discriminate individuals with MDD from individuals without MDD, and to our knowledge no investigations have examined a remitted (r) population. In this study, we examined the efficiency of support vector machine (SVM) classifier to successfully discriminate rMDD individuals from healthy controls (HCs) in a narrow early-adult age range. We empirically evaluated four feature selection methods including multivariate Least Absolute Shrinkage and Selection Operator (LASSO) and Elastic Net feature selection algorithms. Our results showed that SVM classification with Elastic Net feature selection achieved the highest classification accuracy of 76.1% (sensitivity of 81.5% and specificity of 68.9%) by leave-one-out cross-validation across subjects from a dataset consisting of 38 rMDD individuals and 29 healthy controls. The highest discriminating functional connections were between the left amygdala, left posterior cingulate cortex, bilateral dorso-lateral prefrontal cortex, and right ventral striatum. These appear to be key nodes in the etiopathophysiology of MDD, within and between default mode, salience and cognitive control networks. This technique demonstrates early promise for using rs-fMRI connectivity as a putative neurobiological marker capable of distinguishing between individuals with and without rMDD. These methods may be extended to periods of risk prior to illness onset, thereby allowing for earlier diagnosis, prevention, and intervention.

  14. Effective brain network analysis with resting-state EEG data: a comparison between heroin abstinent and non-addicted subjects

    Science.gov (United States)

    Hu, Bin; Dong, Qunxi; Hao, Yanrong; Zhao, Qinglin; Shen, Jian; Zheng, Fang

    2017-08-01

    Objective. Neuro-electrophysiological tools have been widely used in heroin addiction studies. Previous studies indicated that chronic heroin abuse would result in abnormal functional organization of the brain, while few heroin addiction studies have applied the effective connectivity tool to analyze the brain functional system (BFS) alterations induced by heroin abuse. The present study aims to identify the abnormality of resting-state heroin abstinent BFS using source decomposition and effective connectivity tools. Approach. The resting-state electroencephalograph (EEG) signals were acquired from 15 male heroin abstinent (HA) subjects and 14 male non-addicted (NA) controls. Multivariate autoregressive models combined independent component analysis (MVARICA) was applied for blind source decomposition. Generalized partial directed coherence (GPDC) was applied for effective brain connectivity analysis. Effective brain networks of both HA and NA groups were constructed. The two groups of effective cortical networks were compared by the bootstrap method. Abnormal causal interactions between decomposed source regions were estimated in the 1-45 Hz frequency domain. Main results. This work suggested: (a) there were clear effective network alterations in heroin abstinent subject groups; (b) the parietal region was a dominant hub of the abnormally weaker causal pathways, and the left occipital region was a dominant hub of the abnormally stronger causal pathways. Significance. These findings provide direct evidence that chronic heroin abuse induces brain functional abnormalities. The potential value of combining effective connectivity analysis and brain source decomposition methods in exploring brain alterations of heroin addicts is also implied.

  15. Non-local correlations within dynamical mean field theory

    Energy Technology Data Exchange (ETDEWEB)

    Li, Gang

    2009-03-15

    The contributions from the non-local fluctuations to the dynamical mean field theory (DMFT) were studied using the recently proposed dual fermion approach. Straight forward cluster extensions of DMFT need the solution of a small cluster, where all the short-range correlations are fully taken into account. All the correlations beyond the cluster scope are treated in the mean-field level. In the dual fermion method, only a single impurity problem needs to be solved. Both the short and long-range correlations could be considered on equal footing in this method. The weak-coupling nature of the dual fermion ensures the validity of the finite order diagram expansion. The one and two particle Green's functions calculated from the dual fermion approach agree well with the Quantum Monte Carlo solutions, and the computation time is considerably less than with the latter method. The access of the long-range order allows us to investigate the collective behavior of the electron system, e.g. spin wave excitations. (orig.)

  16. Black supernovae and black holes in non-local gravity

    Energy Technology Data Exchange (ETDEWEB)

    Bambi, Cosimo [Center for Field Theory and Particle Physics and Department of Physics, Fudan University,200433 Shanghai (China); Theoretical Astrophysics, Eberhard-Karls Universität Tübingen,72076 Tübingen (Germany); Malafarina, Daniele [Department of Physics, Nazarbayev University,010000 Astana (Kazakhstan); Modesto, Leonardo [Center for Field Theory and Particle Physics and Department of Physics, Fudan University,200433 Shanghai (China)

    2016-04-22

    In a previous paper, we studied the interior solution of a collapsing body in a non-local theory of gravity super-renormalizable at the quantum level. We found that the classical singularity is replaced by a bounce, after which the body starts expanding. A black hole, strictly speaking, never forms. The gravitational collapse does not create an event horizon but only an apparent one for a finite time. In this paper, we solve the equations of motion assuming that the exterior solution is static. With such an assumption, we are able to reconstruct the solution in the whole spacetime, namely in both the exterior and interior regions. Now the gravitational collapse creates an event horizon in a finite comoving time, but the central singularity is approached in an infinite time. We argue that these black holes should be unstable, providing a link between the scenarios with and without black holes. Indeed, we find a non catastrophic ghost-instability of the metric in the exterior region. Interestingly, under certain conditions, the lifetime of our black holes exactly scales as the Hawking evaporation time.

  17. Cosmological evolution of generalized non-local gravity

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xue; Wu, Ya-Bo; Liu, Yu-Chen; Chen, Bo-Hai; Chai, Yun-Tian; Shu, Shuang [Department of Physics, Liaoning Normal University, Dalian 116029 (China); Li, Song, E-mail: zxue0128@163.com, E-mail: ybwu61@163.com, E-mail: sli@cnu.edu.cn, E-mail: wuli11liuyuchen@163.com, E-mail: bchenphy@163.com, E-mail: chaiyuntian1881@sina.com, E-mail: sshu1230@163.com [Department of Physics, Capital Normal University, Beijing 100048 (China)

    2016-07-01

    We construct a class of generalized non-local gravity (GNLG) model which is the modified theory of general relativity (GR) obtained by adding a term m {sup 2} {sup n} {sup -2} R □{sup -} {sup n} R to the Einstein-Hilbert action. Concretely, we not only study the gravitational equation for the GNLG model by introducing auxiliary scalar fields, but also analyse the classical stability and examine the cosmological consequences of the model for different exponent n . We find that the half of the scalar fields are always ghost-like and the exponent n must be taken even number for a stable GNLG model. Meanwhile, the model spontaneously generates three dominant phases of the evolution of the universe, and the equation of state parameters turn out to be phantom-like. Furthermore, we clarify in another way that exponent n should be even numbers by the spherically symmetric static solutions in Newtonian gauge. It is worth stressing that the results given by us can include ones in refs. [28, 34] as the special case of n =2.

  18. Non-local correlations within dynamical mean field theory

    International Nuclear Information System (INIS)

    Li, Gang

    2009-03-01

    The contributions from the non-local fluctuations to the dynamical mean field theory (DMFT) were studied using the recently proposed dual fermion approach. Straight forward cluster extensions of DMFT need the solution of a small cluster, where all the short-range correlations are fully taken into account. All the correlations beyond the cluster scope are treated in the mean-field level. In the dual fermion method, only a single impurity problem needs to be solved. Both the short and long-range correlations could be considered on equal footing in this method. The weak-coupling nature of the dual fermion ensures the validity of the finite order diagram expansion. The one and two particle Green's functions calculated from the dual fermion approach agree well with the Quantum Monte Carlo solutions, and the computation time is considerably less than with the latter method. The access of the long-range order allows us to investigate the collective behavior of the electron system, e.g. spin wave excitations. (orig.)

  19. Path entanglement of photons by non-local bunching

    International Nuclear Information System (INIS)

    Eisenberg, H.; Hodelin, J.; Khoury, G.; Bouwmeester, D.

    2005-01-01

    Full Text:Path entangled photon states can be used to overcome classical limits on the accuracy of interferometric measurements such as the diffraction limit. These states are superpositions of finding n photons in one out of two (or more) paths. Using stimulated parametric down-conversion, we propose and demonstrate a method for generating heralded multiphoton path entanglement, without applying post-selection. parametric down-conversion is relatively easy to produce compared to pure Fock states as demanded by other proposals. By a special coincidence detection at one down converted arm, the photons of the second arm non-locally bunch into the desired state. Entanglement in photon number is created between two polarization modes rather than two paths. A polarization beam-splitter and a 2 wave plate can translate between the two representations. The experimental generation of a two-photon path entangled state was detected by observing interference at half the photon wavelength. The scheme is generally extendable to higher photon numbers

  20. Application of the Modified Vlasov Model to the Free Vibration Analysis of Thick Plates Resting on Elastic Foundations

    Directory of Open Access Journals (Sweden)

    Korhan Ozgan

    2009-01-01

    Full Text Available The Modified Vlasov Model is applied to the free vibration analysis of thick plates resting on elastic foundations. The effects of the subsoil depth, plate dimensions and their ratio, the value of the vertical deformation parameter within the subsoil on the frequency parameters of plates on elastic foundations are investigated. A four-noded, twelve degrees of freedom quadrilateral finite element (PBQ4 is used for plate bending analysis based on Mindlin plate theory which is effectively applied to the analysis of thin and thick plates when selective reduced integration technique is used. The first ten natural frequency parameters are presented in tabular and graphical forms to show the effects of the parameters considered in the study. It is concluded that the effect of the subsoil depth on the frequency parameters of the plates on elastic foundation is generally larger than that of the other parameters considered in the study.

  1. EEG resting state functional connectivity analysis in children with benign epilepsy with centrotemporal spikes

    Directory of Open Access Journals (Sweden)

    Azeez eAdebimpe

    2016-03-01

    Full Text Available In this study, we investigated changes in functional connectivity of the brain networks in patients with benign epilepsy with centrotemporal spikes compared to healthy controls using high-density EEG data collected under eyes-closed resting state condition. EEG source reconstruction was performed with exact Low Resolution Electromagnetic Tomography (eLORETA. We investigated functional connectivity (FC between 84 Brodmann areas using lagged phase synchronization (LPS in four frequency bands (δ, θ, α, and β. We further computed the network degree, clustering coefficient and efficiency. Compared to controls, patients displayed higher θ and α and lower β lagged phase synchronization values. In these frequency bands, patients were also characterized by less well ordered brain networks exhibiting higher global degrees and efficiencies and lower clustering coefficients. In the beta band, patients exhibited reduced functional segregation and integration due to loss of both local and long-distance functional connections. These findings suggest that benign epileptic brain networks might be functionally disrupted due to their altered functional organization especially in the α and β frequency bands.

  2. A Resting-State Brain Functional Network Study in MDD Based on Minimum Spanning Tree Analysis and the Hierarchical Clustering

    Directory of Open Access Journals (Sweden)

    Xiaowei Li

    2017-01-01

    Full Text Available A large number of studies demonstrated that major depressive disorder (MDD is characterized by the alterations in brain functional connections which is also identifiable during the brain’s “resting-state.” But, in the present study, the approach of constructing functional connectivity is often biased by the choice of the threshold. Besides, more attention was paid to the number and length of links in brain networks, and the clustering partitioning of nodes was unclear. Therefore, minimum spanning tree (MST analysis and the hierarchical clustering were first used for the depression disease in this study. Resting-state electroencephalogram (EEG sources were assessed from 15 healthy and 23 major depressive subjects. Then the coherence, MST, and the hierarchical clustering were obtained. In the theta band, coherence analysis showed that the EEG coherence of the MDD patients was significantly higher than that of the healthy controls especially in the left temporal region. The MST results indicated the higher leaf fraction in the depressed group. Compared with the normal group, the major depressive patients lost clustering in frontal regions. Our findings suggested that there was a stronger brain interaction in the MDD group and a left-right functional imbalance in the frontal regions for MDD controls.

  3. Quantum objects. Non-local correlation, causality and objective indefiniteness in the quantum world

    International Nuclear Information System (INIS)

    Jaeger, Gregg

    2014-01-01

    Presents interpretation of quantum mechanics, advances in quantum foundations and philosophy of quantum mechanics. Explains non-locality and its relationship to causality and probability in quantum theory. Displays foundational characteristics of quantum physic to understand conceptual origins of the unusual nature of quantum phenomena. Describes relationship of subsystems and space-time. Gives a careful review of existing views. Confronts the old approaches with recent results and approaches from quantum information theory. Delivers a clear and thorough analysis of the quantum events in the context of relativistic space-time, which impacts the problem of creating a theory of quantum gravity. Supplies a detailed discussion of non-local correlation within and beyond the bounds set by standard quantum mechanics, which impacts the foundations of information theory. Gives a detailed discussion of probabilistic causation (central to contemporary accounts of causation) in quantum mechanics and relativity. Leads a thorough discussion of the nature of ''quantum potentiality,'' the novel form of existence arising for the first time in quantum mechanics. This monograph identifies the essential characteristics of the objects described by current quantum theory and considers their relationship to space-time. In the process, it explicates the senses in which quantum objects may be consistently considered to have parts of which they may be composed or into which they may be decomposed. The book also demonstrates the degree to which reduction is possible in quantum mechanics, showing it to be related to the objective indefiniteness of quantum properties and the strong non-local correlations that can occur between the physical quantities of quantum subsystems. Careful attention is paid to the relationships among such property correlations, physical causation, probability, and symmetry in quantum theory. In this way, the text identifies and clarifies the conceptual grounds

  4. Quantum objects. Non-local correlation, causality and objective indefiniteness in the quantum world

    Energy Technology Data Exchange (ETDEWEB)

    Jaeger, Gregg [Boston Univ., MA (United States). Natural Sciences and Mathematics

    2014-07-01

    Presents interpretation of quantum mechanics, advances in quantum foundations and philosophy of quantum mechanics. Explains non-locality and its relationship to causality and probability in quantum theory. Displays foundational characteristics of quantum physic to understand conceptual origins of the unusual nature of quantum phenomena. Describes relationship of subsystems and space-time. Gives a careful review of existing views. Confronts the old approaches with recent results and approaches from quantum information theory. Delivers a clear and thorough analysis of the quantum events in the context of relativistic space-time, which impacts the problem of creating a theory of quantum gravity. Supplies a detailed discussion of non-local correlation within and beyond the bounds set by standard quantum mechanics, which impacts the foundations of information theory. Gives a detailed discussion of probabilistic causation (central to contemporary accounts of causation) in quantum mechanics and relativity. Leads a thorough discussion of the nature of ''quantum potentiality,'' the novel form of existence arising for the first time in quantum mechanics. This monograph identifies the essential characteristics of the objects described by current quantum theory and considers their relationship to space-time. In the process, it explicates the senses in which quantum objects may be consistently considered to have parts of which they may be composed or into which they may be decomposed. The book also demonstrates the degree to which reduction is possible in quantum mechanics, showing it to be related to the objective indefiniteness of quantum properties and the strong non-local correlations that can occur between the physical quantities of quantum subsystems. Careful attention is paid to the relationships among such property correlations, physical causation, probability, and symmetry in quantum theory. In this way, the text identifies and clarifies the

  5. Large deflection analysis of laminated composite plates resting on nonlinear elastic foundations by the method of discrete singular convolution

    International Nuclear Information System (INIS)

    Baltacioglu, A.K.; Civalek, O.; Akgoez, B.; Demir, F.

    2011-01-01

    This paper presents nonlinear static analysis of a rectangular laminated composite thick plate resting on nonlinear two-parameter elastic foundation with cubic nonlinearity. The plate formulation is based on first-order shear deformation theory (FSDT). The governing equation of motion for a rectangular laminated composite thick plate is derived by using the von Karman equation. The nonlinear static deflections of laminated plates on elastic foundation are investigated using the discrete singular convolution method. The effects of foundation and geometric parameters of plates on nonlinear deflections are investigated. The validity of the present method is demonstrated by comparing the present results with those available in the literature. - Highlights: → Large deflection analysis of laminated composite plates are investigated. → As foundation, nonlinear elastic models have been used firstly. → The effects of three-parameter foundation are investigated in detail.

  6. Network based statistical analysis detects changes induced by continuous theta burst stimulation on brain activity at rest.

    Directory of Open Access Journals (Sweden)

    Chiara eMastropasqua

    2014-08-01

    Full Text Available We combined continuous theta burst stimulation (cTBS and resting state (RS -fMRI approaches to investigate changes in functional connectivity (FC induced by right dorso-lateral prefrontal cortex (DLPFC cTBS at rest in a group of healthy subjects. Seed based fMRI analysis revealed a specific pattern of correlation between the right prefrontal cortex and several brain regions: based on these results, we defined a 29-node network to assess changes in each network connection before and after, respectively, DLPFC-cTBS and sham sessions. A decrease of correlation between the right prefrontal cortex and right parietal cortex (Brodmann areas 46 and 40 respectively was detected after cTBS, while no significant result was found when analyzing sham-session data. To our knowledge, this is the first study that demonstrates within-subject changes in FC induced by cTBS applied on prefrontal area. The possibility to induce selective changes in a specific region without interfering with functionally correlated area could have several implications for the study of functional properties of the brain, and for the emerging therapeutic strategies based on transcranial stimulation.

  7. Normal left ventricular emptying in coronary artery disease at rest: analysis by radiographic and equilibrium radionuclide ventriculography

    International Nuclear Information System (INIS)

    Denenberg, B.S.; Makler, P.T.; Bove, A.A.; Spann, J.F.

    1981-01-01

    The volume ejected early in systole has been proposed as an indicator of abnormal left ventricular function that is present at rest in patients with coronary artery disease with a normal ejection fraction and normal wall motion. The volume ejected in systole was examined by calculating the percent change in ventricular volume using both computer-assisted analysis of biplane radiographic ventriculograms at 60 frames/s and equilibrium gated radionuclide ventriculograms. Ventricular emptying was examined with radiographic ventriculography in 33 normal patients and 23 patients with coronary artery disease and normal ejection fraction. Eight normal subjects and six patients with coronary artery disease had both radiographic ventriculography and equilibrium gated radionuclide ventriculography. In all patients, there was excellent correlation between the radiographic and radionuclide ventricular emptying curves (r . 0.971). There were no difference in the ventricular emptying curves of normal subjects and patients with coronary artery disease whether volumes were measured by radiographic or equilibrium gated radionuclide ventriculography. It is concluded that the resting ventricular emptying curves are identical in normal subjects and patients with coronary artery disease who have a normal ejection fraction and normal wall motion

  8. Neurobiological changes of schizotypy: evidence from both volume-based morphometric analysis and resting-state functional connectivity.

    Science.gov (United States)

    Wang, Yi; Yan, Chao; Yin, Da-zhi; Fan, Ming-xia; Cheung, Eric F C; Pantelis, Christos; Chan, Raymond C K

    2015-03-01

    The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks derived from brain structural and functional imaging. Individuals with high schizotypy (n = 35) and low schizotypy (n = 34) controls were screened using the Schizotypal Personality Questionnaire and underwent brain structural and resting-state functional magnetic resonance imaging on a 3T scanner. Voxel-based morphometric analysis and graph theory-based functional network analysis were conducted. Individuals with high schizotypy showed reduced gray matter (GM) density in the insula and the dorsolateral prefrontal gyrus. The graph theoretical analysis showed that individuals with high schizotypy showed similar global properties in their functional networks as low schizotypy individuals. Several hubs of the functional network were identified in both groups, including the insula, the lingual gyrus, the postcentral gyrus, and the rolandic operculum. More hubs in the frontal lobe and fewer hubs in the occipital lobe were identified in individuals with high schizotypy. By comparing the functional connectivity between clusters with abnormal GM density and the whole brain, individuals with high schizotypy showed weaker functional connectivity between the left insula and the putamen, but stronger connectivity between the cerebellum and the medial frontal gyrus. Taken together, our findings suggest that individuals with high schizotypy present changes in terms of GM and resting-state functional connectivity, especially in the frontal lobe. © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  9. Effect of phase-encoding direction on group analysis of resting-state functional magnetic resonance imaging.

    Science.gov (United States)

    Mori, Yasuo; Miyata, Jun; Isobe, Masanori; Son, Shuraku; Yoshihara, Yujiro; Aso, Toshihiko; Kouchiyama, Takanori; Murai, Toshiya; Takahashi, Hidehiko

    2018-05-17

    Echo-planar imaging is a common technique used in functional magnetic resonance imaging (fMRI), however it suffers from image distortion and signal loss because of large susceptibility effects that are related to the phase-encoding direction of the scan. Despite this relationship, the majority of neuroimaging studies have not considered the influence of phase-encoding direction. Here, we aimed to clarify how phase-encoding direction can affect the outcome of an fMRI connectivity study of schizophrenia. Resting-state fMRI using anterior to posterior (A-P) and posterior to anterior (P-A) directions was used to examine 25 patients with schizophrenia (SC) and 37 matched healthy controls (HC). We conducted a functional connectivity analysis using independent component analysis and performed three group comparisons: A-P vs. P-A (all participants), SC vs. HC for the A-P and P-A datasets, and the interaction between phase-encoding direction and participant group. The estimated functional connectivity differed between the two phase-encoding directions in areas that were more extensive than those where signal loss has been reported. Although functional connectivity in the SC group was lower than that in the HC group for both directions, the A-P and P-A conditions did not exhibit the same specific pattern of differences. Further, we observed an interaction between participant group and the phase-encoding direction in the left temporo-parietal junction and left fusiform gyrus. Phase-encoding direction can influence the results of functional connectivity studies. Thus, appropriate selection and documentation of phase-encoding direction will be important in future resting-state fMRI studies. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  10. A Morphing framework to couple non-local and local anisotropic continua

    KAUST Repository

    Azdoud, Yan

    2013-05-01

    In this article, we develop a method to couple anisotropic local continua with anisotropic non-local continua with central long-range forces. First, we describe anisotropic non-local models based on spherical harmonic descriptions. We then derive compatible classic continuum models. Finally, we apply the morphing method to these anisotropic non-local models and present three-dimensional numerical examples to validate the efficiency of the technique. © 2013 Elsevier Ltd. All rights reserved.

  11. Non-local currents in 2D QFT: an alternative To - the quantum inverse scattering method

    International Nuclear Information System (INIS)

    Bernard, D.; Leclair, A.; Cornell Univ., Ithaca, NY

    1990-01-01

    The formalism based on non-local charges that we propose provides an alternative to the quantum inverse scattering method for solving integrable quantum field theories in 2D. The content of the paper is: 1. Introduction: historical background. 2. The NLC approach to 2D QFT: a summary. 3 Exchange algebras and on-shell conservation laws: why non-local charges are useful. 4. The lattice construction: the geometrical origin of non-local conserved currents. 5. The continuum construction: how to deal with non-local conserved currents. 6. Examples: Yangian and quantum group currents. 7 Conclusions: open problems. 22 refs., 4 figs

  12. Identifying Subgroups of Tinnitus Using Novel Resting State fMRI Biomarkers and Cluster Analysis

    Science.gov (United States)

    2017-10-13

    psychological therapies or pharmacological drugs. 2. KEYWORDS: fMRI (functional magnetic resonance imaging), tinnitus, brain imaging, cluster analysis...9/2016). Details in next section.  6-9 months: • Task 2: Participant recruitment, participant evaluation, MRI and behavioral data acquisition 3...WHASC: N = 40 patients and 20 controls o For year 2 (at end of first 24 months) details see next section. • Task 4: Behavioral and MRI data

  13. A method for independent component graph analysis of resting-state fMRI

    DEFF Research Database (Denmark)

    de Paula, Demetrius Ribeiro; Ziegler, Erik; Abeyasinghe, Pubuditha M.

    2017-01-01

    Introduction Independent component analysis (ICA) has been extensively used for reducing task-free BOLD fMRI recordings into spatial maps and their associated time-courses. The spatially identified independent components can be considered as intrinsic connectivity networks (ICNs) of non-contiguou......Introduction Independent component analysis (ICA) has been extensively used for reducing task-free BOLD fMRI recordings into spatial maps and their associated time-courses. The spatially identified independent components can be considered as intrinsic connectivity networks (ICNs) of non......-contiguous regions. To date, the spatial patterns of the networks have been analyzed with techniques developed for volumetric data. Objective Here, we detail a graph building technique that allows these ICNs to be analyzed with graph theory. Methods First, ICA was performed at the single-subject level in 15 healthy...... parcellated regions. Third, between-node functional connectivity was established by building edge weights for each networks. Group-level graph analysis was finally performed for each network and compared to the classical network. Results Network graph comparison between the classically constructed network...

  14. Differences in hemispherical thalamo-cortical causality analysis during resting-state fMRI.

    Science.gov (United States)

    Anwar, Abdul Rauf; Muthalib, Makii; Perrey, Stephane; Wolff, Stephan; Deuschl, Guunther; Heute, Ulrich; Muthuraman, Muthuraman

    2014-01-01

    Thalamus is a very important part of the human brain. It has been reported to act as a relay for the messaging taking place between the cortical and sub-cortical regions of the brain. In the present study, we analyze the functional network between both hemispheres of the brain with the focus on thalamus. We used conditional Granger causality (CGC) and time-resolved partial directed coherence (tPDC) to investigate the functional connectivity. Results of CGC analysis revealed the asymmetry between connection strengths of the bilateral thalamus. Upon testing the functional connectivity of the default-mode network (DMN) at low-frequency fluctuations (LFF) and comparing coherence vectors using Spearman's rank correlation, we found that thalamus is a better source for the signals directed towards the contralateral regions of the brain, however, when thalamus acts as sink, it is a better sink for signals generated from ipsilateral regions of the brain.

  15. Effect of non-local equilibrium on minimal thermal resistance porous layered systems

    International Nuclear Information System (INIS)

    Leblond, Genevieve; Gosselin, Louis

    2008-01-01

    In this paper, the cooling of a heat-generating surface by a stacking of porous media (e.g., metallic foam) through which fluid flows parallel to the surface is considered. A two-temperature model is proposed to account for non-local thermal equilibrium (non-LTE). A scale analysis is performed to determine temperatures profiles in the boundary layer regime. The hot spot temperature is minimized with respect to the three design variables of each layer: porosity, pore diameter, and material. Global cost and mass are constrained. The optimization is performed with a hybrid genetic algorithm (GA) including local search to enhance convergence and repeatability. Results demonstrate that the optimized stacks do not operate in LTE. Therefore, we show that assuming LTE might result in underestimation of the hot spot temperature, and into different final designs as well

  16. Energy method for multi-dimensional balance laws with non-local dissipation

    KAUST Repository

    Duan, Renjun

    2010-06-01

    In this paper, we are concerned with a class of multi-dimensional balance laws with a non-local dissipative source which arise as simplified models for the hydrodynamics of radiating gases. At first we introduce the energy method in the setting of smooth perturbations and study the stability of constants states. Precisely, we use Fourier space analysis to quantify the energy dissipation rate and recover the optimal time-decay estimates for perturbed solutions via an interpolation inequality in Fourier space. As application, the developed energy method is used to prove stability of smooth planar waves in all dimensions n2, and also to show existence and stability of time-periodic solutions in the presence of the time-periodic source. Optimal rates of convergence of solutions towards the planar waves or time-periodic states are also shown provided initially L1-perturbations. © 2009 Elsevier Masson SAS.

  17. Energy method for multi-dimensional balance laws with non-local dissipation

    KAUST Repository

    Duan, Renjun; Fellner, Klemens; Zhu, Changjiang

    2010-01-01

    In this paper, we are concerned with a class of multi-dimensional balance laws with a non-local dissipative source which arise as simplified models for the hydrodynamics of radiating gases. At first we introduce the energy method in the setting of smooth perturbations and study the stability of constants states. Precisely, we use Fourier space analysis to quantify the energy dissipation rate and recover the optimal time-decay estimates for perturbed solutions via an interpolation inequality in Fourier space. As application, the developed energy method is used to prove stability of smooth planar waves in all dimensions n2, and also to show existence and stability of time-periodic solutions in the presence of the time-periodic source. Optimal rates of convergence of solutions towards the planar waves or time-periodic states are also shown provided initially L1-perturbations. © 2009 Elsevier Masson SAS.

  18. Non-local setting and outcome information for violation of Bell's inequality

    International Nuclear Information System (INIS)

    Pawlowski, Marcin; Kofler, Johannes; Paterek, Tomasz; Brukner, Caslav; Seevinck, Michael

    2010-01-01

    Bell's theorem is a no-go theorem stating that quantum mechanics cannot be reproduced by a physical theory based on realism, freedom to choose experimental settings and two locality conditions: setting (SI) and outcome (OI) independence. We provide a novel analysis of what it takes to violate Bell's inequality within the framework in which both realism and freedom of choice are assumed, by showing that it is impossible to model a violation without having information in one laboratory about both the setting and the outcome at the distant one. While it is possible that outcome information can be revealed from shared hidden variables, the assumed experimenter's freedom to choose the settings ensures that the setting information must be non-locally transferred even when the SI condition is obeyed. The amount of transmitted information about the setting that is sufficient to violate the CHSH inequality up to its quantum mechanical maximum is 0.736 bits.

  19. Connectome-scale group-wise consistent resting-state network analysis in autism spectrum disorder

    Directory of Open Access Journals (Sweden)

    Yu Zhao

    2016-01-01

    Full Text Available Understanding the organizational architecture of human brain function and its alteration patterns in diseased brains such as Autism Spectrum Disorder (ASD patients are of great interests. In-vivo functional magnetic resonance imaging (fMRI offers a unique window to investigate the mechanism of brain function and to identify functional network components of the human brain. Previously, we have shown that multiple concurrent functional networks can be derived from fMRI signals using whole-brain sparse representation. Yet it is still an open question to derive group-wise consistent networks featured in ASD patients and controls. Here we proposed an effective volumetric network descriptor, named connectivity map, to compactly describe spatial patterns of brain network maps and implemented a fast framework in Apache Spark environment that can effectively identify group-wise consistent networks in big fMRI dataset. Our experiment results identified 144 group-wisely common intrinsic connectivity networks (ICNs shared between ASD patients and healthy control subjects, where some ICNs are substantially different between the two groups. Moreover, further analysis on the functional connectivity and spatial overlap between these 144 common ICNs reveals connectomics signatures characterizing ASD patients and controls. In particular, the computing time of our Spark-enabled functional connectomics framework is significantly reduced from 240 hours (C++ code, single core to 20 hours, exhibiting a great potential to handle fMRI big data in the future.

  20. Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis.

    Science.gov (United States)

    Burré, Jacqueline; Beckhaus, Tobias; Corvey, Carsten; Karas, Michael; Zimmermann, Herbert; Volknandt, Walter

    2006-09-01

    Synaptic vesicles are organelles of the nerve terminal that secrete neurotransmitters by fusion with the presynaptic plasma membrane. Vesicle fusion is tightly controlled by depolarization of the plasma membrane and a set of proteins that may undergo post-translational modifications such as phosphorylation. In order to identify proteins that undergo modifications as a result of synaptic activation, we induced massive exocytosis and analysed the synaptic vesicle compartment by benzyldimethyl-n-hexadecylammonium chloride (BAC)/SDS-PAGE and difference gel electrophoresis (DIGE) followed by MALDI-TOF-MS. We identified eight proteins that revealed significant changes in abundance following nerve terminal depolarization. Of these, six were increased and two were decreased in abundance. Three of these proteins were phosphorylated as detected by Western blot analysis. In addition, we identified an unknown synaptic vesicle protein whose abundance increased on synaptic activation. Our results demonstrate that depolarization of the presynaptic compartment induces changes in the abundance of synaptic vesicle proteins and post-translational protein modification.

  1. A generalized non-local optical response theory for plasmonic nanostructures

    DEFF Research Database (Denmark)

    Mortensen, N. Asger; Raza, Søren; Wubs, Martijn

    2014-01-01

    for their description. Here instead we present a comparatively simple semiclassical generalized non-local optical response theory that unifies quantum pressure convection effects and induced charge diffusion kinetics, with a concomitant complex-valued generalized non-local optical response parameter. Our theory...

  2. Local and non-local equivalent potentials for p-12C scattering

    International Nuclear Information System (INIS)

    Lovell, A.; Amos, K.

    2000-01-01

    A Newton-Sabatier fixed energy inversion scheme has been used to equate inherently non-local p- 12 C potentials at a variety of energies to pion threshold, with exactly phase equivalent local ones. Those energy dependent local potentials then have been recast in the form of non-local Frahn-Lemmer interactions

  3. Bosonization, dual transformation and non-local hidden symmetry in two dimensions

    International Nuclear Information System (INIS)

    Hata, Hiroyuki

    1985-01-01

    The non-local hidden symmetry is investigated in the bosonized non-abelian Thirring model and the dual representation of the chiral model. In these representations the first non-local symmetry is spontaneously broken in naive pertubation theory. (orig.)

  4. Non-local energy deposition: A problem in regional RF hyperthermia

    International Nuclear Information System (INIS)

    Hagmann, M.J.; Levin, R.L.

    1984-01-01

    As the frequency is decreased below 1 GHz, RF applicators can cause deep heating of tissues. However, there is a concomitant problem in that significant energy deposition may occur well beyond the dimensions of the applicator. The BSD Medical Corporation has described to the authors tests with a phantom manequin in which SAR in the neck was significantly greater than that in the abdomen when an Annular Phased Array System (APAS) was positioned for abdominal heating. The authors have obtained numerical solutions for the SAR distribution in a 180-cell inhomogeneous block model of man subjected to r-f irradiation approximating that emanating from various applicators. The solutions agree with the reports of BSD that significant heating in the neck, inner thighs, and back will occur with an abdominally-placed APAS. They suggest that a similar problem will occur with a helical-coil or other applicator for which the electric field is predominantly parallel to the axis of the body. Typically, 70% or more of the total energy will be deposited outside the bounds of an axial applicator when it is placed around the chest or abdomen. The problem is most severe at frequencies for which body parts such as the arm or head may resonate. In such cases, over 90% of the energy may be deposited outside the bounds of applicator. The problem of non-local energy deposition appears to be substantially reduced for non-axial applicators. If the arm extends outward from the side of the body, an axial applicator around it will cause negligible energy deposition in the rest of the body

  5. A Skew-t space-varying regression model for the spectral analysis of resting state brain activity.

    Science.gov (United States)

    Ismail, Salimah; Sun, Wenqi; Nathoo, Farouk S; Babul, Arif; Moiseev, Alexader; Beg, Mirza Faisal; Virji-Babul, Naznin

    2013-08-01

    It is known that in many neurological disorders such as Down syndrome, main brain rhythms shift their frequencies slightly, and characterizing the spatial distribution of these shifts is of interest. This article reports on the development of a Skew-t mixed model for the spatial analysis of resting state brain activity in healthy controls and individuals with Down syndrome. Time series of oscillatory brain activity are recorded using magnetoencephalography, and spectral summaries are examined at multiple sensor locations across the scalp. We focus on the mean frequency of the power spectral density, and use space-varying regression to examine associations with age, gender and Down syndrome across several scalp regions. Spatial smoothing priors are incorporated based on a multivariate Markov random field, and the markedly non-Gaussian nature of the spectral response variable is accommodated by the use of a Skew-t distribution. A range of models representing different assumptions on the association structure and response distribution are examined, and we conduct model selection using the deviance information criterion. (1) Our analysis suggests region-specific differences between healthy controls and individuals with Down syndrome, particularly in the left and right temporal regions, and produces smoothed maps indicating the scalp topography of the estimated differences.

  6. Mapping brain functional alterations in betel-quid chewers using resting-state fMRI and network analysis.

    Science.gov (United States)

    Weng, Jun-Cheng; Chou, Yu-Syuan; Huang, Guo-Joe; Tyan, Yeu-Sheng; Ho, Ming-Chou

    2018-04-01

    The World Health Organization regards betel quid (BQ) as a human carcinogen, and DSM-IV and ICD-10 dependence symptoms may develop with its heavy use. BQ's possible effects of an enhanced reward system and disrupted inhibitory control may increase the likelihood of habitual substance use. The current study aimed to employ resting-state fMRI to examine the hypothesized enhanced reward system (e.g., the basal forebrain system) and disrupted inhibitory control (e.g., the prefrontal system) in BQ chewers. The current study recruited three groups of 48 male participants: 16 BQ chewers, 15 tobacco- and alcohol-user controls, and 17 healthy controls. We used functional connectivity (FC), mean fractional amplitude of low-frequency fluctuations (mfALFF), and mean regional homogeneity (mReHo) to evaluate functional alternations in BQ chewers. Graph theoretical analysis (GTA) and network-based statistical (NBS) analysis were also performed to identify the functional network differences among the three groups. Our hypothesis was partially supported: the enhanced reward system for the BQ chewers (e.g., habitual drug-seeking behavior) was supported; however, their inhibitory control was relatively preserved. In addition, we reported that the BQ chewers may have enhanced visuospatial processing and decreased local segregation. The current results (showing an enhanced reward system in the chewers) provided the clinicians with important insight for the future development of an effective abstinence treatment.

  7. A morphing strategy to couple non-local to local continuum mechanics

    KAUST Repository

    Lubineau, Gilles; Azdoud, Yan; Han, Fei; Rey, Christian C.; Askari, Abe H.

    2012-01-01

    A method for coupling non-local continuum models with long-range central forces to local continuum models is proposed. First, a single unified model that encompasses both local and non-local continuum representations is introduced. This model can be purely non-local, purely local or a hybrid depending on the constitutive parameters. Then, the coupling between the non-local and local descriptions is performed through a transition (morphing) affecting only the constitutive parameters. An important feature is the definition of the morphing functions, which relies on energy equivalence. This approach is useful in large-scale modeling of materials that exhibit strong non-local effects. The computational cost can be reduced while maintaining a reasonable level of accuracy. Efficiency, robustness and basic properties of the approach are discussed using one- and two-dimensional examples. © 2012 Elsevier Ltd.

  8. A morphing strategy to couple non-local to local continuum mechanics

    KAUST Repository

    Lubineau, Gilles

    2012-06-01

    A method for coupling non-local continuum models with long-range central forces to local continuum models is proposed. First, a single unified model that encompasses both local and non-local continuum representations is introduced. This model can be purely non-local, purely local or a hybrid depending on the constitutive parameters. Then, the coupling between the non-local and local descriptions is performed through a transition (morphing) affecting only the constitutive parameters. An important feature is the definition of the morphing functions, which relies on energy equivalence. This approach is useful in large-scale modeling of materials that exhibit strong non-local effects. The computational cost can be reduced while maintaining a reasonable level of accuracy. Efficiency, robustness and basic properties of the approach are discussed using one- and two-dimensional examples. © 2012 Elsevier Ltd.

  9. Surface effects on static bending of nanowires based on non-local elasticity theory

    Directory of Open Access Journals (Sweden)

    Quan Wu

    2015-10-01

    Full Text Available The surface elasticity and non-local elasticity effects on the elastic behavior of statically bent nanowires are investigated in the present investigation. Explicit solutions are presented to evaluate the surface stress and non-local elasticity effects with various boundary conditions. Compared with the classical Euler beam, a nanowire with surface stress and/or non-local elasticity can be either stiffer or less stiff, depending on the boundary conditions. The concept of surface non-local elasticity was proposed and its physical interpretation discussed to explain the combined effect of surface elasticity and non-local elasticity. The effect of the nanowire size on its elastic bending behavior was investigated. The results obtained herein are helpful to characterize mechanical properties of nanowires and aid nanowire-based devices design.

  10. A novel model-free data analysis technique based on clustering in a mutual information space: application to resting-state fMRI

    Directory of Open Access Journals (Sweden)

    Simon Benjaminsson

    2010-08-01

    Full Text Available Non-parametric data-driven analysis techniques can be used to study datasets with few assumptions about the data and underlying experiment. Variations of Independent Component Analysis (ICA have been the methods mostly used on fMRI data, e.g. in finding resting-state networks thought to reflect the connectivity of the brain. Here we present a novel data analysis technique and demonstrate it on resting-state fMRI data. It is a generic method with few underlying assumptions about the data. The results are built from the statistical relations between all input voxels, resulting in a whole-brain analysis on a voxel level. It has good scalability properties and the parallel implementation is capable of handling large datasets and databases. From the mutual information between the activities of the voxels over time, a distance matrix is created for all voxels in the input space. Multidimensional scaling is used to put the voxels in a lower-dimensional space reflecting the dependency relations based on the distance matrix. By performing clustering in this space we can find the strong statistical regularities in the data, which for the resting-state data turns out to be the resting-state networks. The decomposition is performed in the last step of the algorithm and is computationally simple. This opens up for rapid analysis and visualization of the data on different spatial levels, as well as automatically finding a suitable number of decomposition components.

  11. Generalized non-Local Resistance Expression and its Application in F/N/F Spintronic Structure with Graphene Channel

    Science.gov (United States)

    Wei, Huazhou; Fu, Shiwei

    We report our work on the spin transport properties in the F/N/F(ferromagnets/normal metal/ferromagnets) spintronic structure from a new theoretical perspective. A significant problem in the field is to explain the inferior measured order of magnitude for spin lifetime. Based on the known non-local resistance formula and the mechanism analysis of spin-flipping within the interfaces between F and N, we analytically derive a broadly applicable new non-local resistance expression and a generalized Hanle curve formula. After employing them in the F/N/F structure under different limits, especially in the case of graphene channel, we find that the fitting from experimental data would yield a longer spin lifetime, which approaches its theoretical predicted value in graphene. The authors acknowledge the financial support by China University of Petroleum-Beijing and the Key Laboratory of Optical Detection Technology for Oil and Gas in this institution.

  12. Using non-local databases for the environmental assessment of industrial activities: The case of Latin America

    International Nuclear Information System (INIS)

    Osses de Eicker, Margarita; Hischier, Roland; Hurni, Hans; Zah, Rainer

    2010-01-01

    Nine non-local databases were evaluated with respect to their suitability for the environmental assessment of industrial activities in Latin America. Three assessment methods were considered, namely Life Cycle Assessment (LCA), Environmental Impact Assessment (EIA) and air emission inventories. The analysis focused on data availability in the databases and the applicability of their international data to Latin American industry. The study showed that the European EMEP/EEA Guidebook and the U.S. EPA AP-42 database are the most suitable ones for air emission inventories, whereas the LCI database Ecoinvent is the most suitable one for LCA and EIA. Due to the data coverage in the databases, air emission inventories are easier to develop than LCA or EIA, which require more comprehensive information. One strategy to overcome the limitations of non-local databases for Latin American industry is the combination of validated data from international databases with newly developed local datasets.

  13. Identifying HIV associated neurocognitive disorder using large-scale Granger causality analysis on resting-state functional MRI

    Science.gov (United States)

    DSouza, Adora M.; Abidin, Anas Z.; Leistritz, Lutz; Wismüller, Axel

    2017-02-01

    We investigate the applicability of large-scale Granger Causality (lsGC) for extracting a measure of multivariate information flow between pairs of regional brain activities from resting-state functional MRI (fMRI) and test the effectiveness of these measures for predicting a disease state. Such pairwise multivariate measures of interaction provide high-dimensional representations of connectivity profiles for each subject and are used in a machine learning task to distinguish between healthy controls and individuals presenting with symptoms of HIV Associated Neurocognitive Disorder (HAND). Cognitive impairment in several domains can occur as a result of HIV infection of the central nervous system. The current paradigm for assessing such impairment is through neuropsychological testing. With fMRI data analysis, we aim at non-invasively capturing differences in brain connectivity patterns between healthy subjects and subjects presenting with symptoms of HAND. To classify the extracted interaction patterns among brain regions, we use a prototype-based learning algorithm called Generalized Matrix Learning Vector Quantization (GMLVQ). Our approach to characterize connectivity using lsGC followed by GMLVQ for subsequent classification yields good prediction results with an accuracy of 87% and an area under the ROC curve (AUC) of up to 0.90. We obtain a statistically significant improvement (p<0.01) over a conventional Granger causality approach (accuracy = 0.76, AUC = 0.74). High accuracy and AUC values using our multivariate method to connectivity analysis suggests that our approach is able to better capture changes in interaction patterns between different brain regions when compared to conventional Granger causality analysis known from the literature.

  14. Relative influence of age, resting heart rate and sedentary life style in short-term analysis of heart rate variability

    Directory of Open Access Journals (Sweden)

    E.R. Migliaro

    2001-04-01

    Full Text Available In order to assess the relative influence of age, resting heart rate (HR and sedentary life style, heart rate variability (HRV was studied in two different groups. The young group (YG consisted of 9 sedentary subjects aged 15 to 20 years (YG-S and of 9 nonsedentary volunteers (YG-NS also aged 15 to 20. The elderly sedentary group (ESG consisted of 16 sedentary subjects aged 39 to 82 years. HRV was assessed using a short-term procedure (5 min. R-R variability was calculated in the time-domain by means of the root mean square successive differences. Frequency-domain HRV was evaluated by power spectrum analysis considering high frequency and low frequency bands. In the YG the effort tolerance was ranked in a bicycle stress test. HR was similar for both groups while ESG showed a reduced HRV compared with YG. Within each group, HRV displayed a negative correlation with HR. Although YG-NS had better effort tolerance than YG-S, their HR and HRV were not significantly different. We conclude that HRV is reduced with increasing HR or age, regardless of life style. The results obtained in our short-term study agree with others of longer duration by showing that age and HR are the main determinants of HRV. Our results do not support the idea that changes in HRV are related to regular physical activity.

  15. Relative influence of age, resting heart rate and sedentary life style in short-term analysis of heart rate variability.

    Science.gov (United States)

    Migliaro, E R; Contreras, P; Bech, S; Etxagibel, A; Castro, M; Ricca, R; Vicente, K

    2001-04-01

    In order to assess the relative influence of age, resting heart rate (HR) and sedentary life style, heart rate variability (HRV) was studied in two different groups. The young group (YG) consisted of 9 sedentary subjects aged 15 to 20 years (YG-S) and of 9 nonsedentary volunteers (YG-NS) also aged 15 to 20. The elderly sedentary group (ESG) consisted of 16 sedentary subjects aged 39 to 82 years. HRV was assessed using a short-term procedure (5 min). R-R variability was calculated in the time-domain by means of the root mean square successive differences. Frequency-domain HRV was evaluated by power spectrum analysis considering high frequency and low frequency bands. In the YG the effort tolerance was ranked in a bicycle stress test. HR was similar for both groups while ESG showed a reduced HRV compared with YG. Within each group, HRV displayed a negative correlation with HR. Although YG-NS had better effort tolerance than YG-S, their HR and HRV were not significantly different. We conclude that HRV is reduced with increasing HR or age, regardless of life style. The results obtained in our short-term study agree with others of longer duration by showing that age and HR are the main determinants of HRV. Our results do not support the idea that changes in HRV are related to regular physical activity.

  16. [Remodeling simulation of human femur under bed rest and spaceflight circumstances based on three dimensional finite element analysis].

    Science.gov (United States)

    Yang, Wenting; Wang, Dongmei; Lei, Zhoujixin; Wang, Chunhui; Chen, Shanguang

    2017-12-01

    Astronauts who are exposed to weightless environment in long-term spaceflight might encounter bone density and mass loss for the mechanical stimulus is smaller than normal value. This study built a three dimensional model of human femur to simulate the remodeling process of human femur during bed rest experiment based on finite element analysis (FEA). The remodeling parameters of this finite element model was validated after comparing experimental and numerical results. Then, the remodeling process of human femur in weightless environment was simulated, and the remodeling function of time was derived. The loading magnitude and loading cycle on human femur during weightless environment were increased to simulate the exercise against bone loss. Simulation results showed that increasing loading magnitude is more effective in diminishing bone loss than increasing loading cycles, which demonstrated that exercise of certain intensity could help resist bone loss during long-term spaceflight. At the end, this study simulated the bone recovery process after spaceflight. It was found that the bone absorption rate is larger than bone formation rate. We advise that astronauts should take exercise during spaceflight to resist bone loss.

  17. Abnormal Functional Connectivity of Resting State Network Detection Based on Linear ICA Analysis in Autism Spectrum Disorder.

    Science.gov (United States)

    Bi, Xia-An; Zhao, Junxia; Xu, Qian; Sun, Qi; Wang, Zhigang

    2018-01-01

    Some functional magnetic resonance imaging (fMRI) researches in autism spectrum disorder (ASD) patients have shown that ASD patients have significant impairment in brain response. However, few researchers have studied the functional structure changes of the eight resting state networks (RSNs) in ASD patients. Therefore, research on statistical differences of RSNs between 42 healthy controls (HC) and 50 ASD patients has been studied using linear independent component analysis (ICA) in this paper. Our researches showed that there was abnormal functional connectivity (FC) of RSNs in ASD patients. The RSNs with the decreased FC and increased FC in ASD patients included default mode network (DMN), central executive network (CEN), core network (CN), visual network (VN), self-referential network (SRN) compared to HC. The RSNs with the increased FC in ASD patients included auditory network (AN), somato-motor network (SMN). The dorsal attention network (DAN) in ASD patients showed the decreased FC. Our findings indicate that the abnormal FC in RSNs extensively exists in ASD patients. Our results have important contribution for the study of neuro-pathophysiological mechanisms in ASD patients.

  18. The small length scale effect for a non-local cantilever beam: a paradox solved.

    Science.gov (United States)

    Challamel, N; Wang, C M

    2008-08-27

    Non-local continuum mechanics allows one to account for the small length scale effect that becomes significant when dealing with microstructures or nanostructures. This paper presents some simplified non-local elastic beam models, for the bending analyses of small scale rods. Integral-type or gradient non-local models abandon the classical assumption of locality, and admit that stress depends not only on the strain value at that point but also on the strain values of all points on the body. There is a paradox still unresolved at this stage: some bending solutions of integral-based non-local elastic beams have been found to be identical to the classical (local) solution, i.e. the small scale effect is not present at all. One example is the Euler-Bernoulli cantilever nanobeam model with a point load which has application in microelectromechanical systems and nanoelectromechanical systems as an actuator. In this paper, it will be shown that this paradox may be overcome with a gradient elastic model as well as an integral non-local elastic model that is based on combining the local and the non-local curvatures in the constitutive elastic relation. The latter model comprises the classical gradient model and Eringen's integral model, and its application produces small length scale terms in the non-local elastic cantilever beam solution.

  19. Resting heart rate, physiological stress and disadvantage in Aboriginal and Torres Strait Islander Australians: analysis from a cross-sectional study.

    Science.gov (United States)

    Zhang, Alice; Hughes, Jaquelyne T; Brown, Alex; Lawton, Paul D; Cass, Alan; Hoy, Wendy; O'Dea, Kerin; Maple-Brown, Louise J

    2016-02-11

    Lower socioeconomic status has been linked to long-term stress, which can manifest in individuals as physiological stress. The aim was to explore the relationship between low socioeconomic status and physiological stress in Aboriginal and Torres Strait Islander Australians. Using data from the eGFR Study (a cross-sectional study of 634 Indigenous Australians in urban and remote areas of northern and central Australia), we examined associations between resting heart rate and demographic, socioeconomic, and biomedical factors. An elevated resting heart rate has been proposed as a measure of sustained stress activation and was used as a marker of physiological stress. Relationships were assessed between heart rate and the above variables using univariate and multiple regression analyses. We reported a mean resting heart rate of 74 beats/min in the cohort (mean age 45 years). On multiple regression analysis, higher heart rate was found to be independently associated with Aboriginal ethnicity, being a current smoker, having only primary level schooling, higher HbA1c and higher diastolic blood pressure (model R(2) 0.25). Elevated resting heart rate was associated with lower socioeconomic status and poorer health profile in Aboriginal and Torres Strait Islander Australians. Higher resting heart rate may be an indicator of stress and disadvantage in this population at high risk of chronic diseases.

  20. The effect of non-local higher order stress to predict the nonlinear vibration behavior of carbon nanotube conveying viscous nanoflow

    International Nuclear Information System (INIS)

    Mohammadimehr, M.; Mohammadi-Dehabadi, A.A.; Maraghi, Z. Khoddami

    2017-01-01

    In this research, the effect of non-local higher order stress on the nonlinear vibration behavior of carbon nanotube conveying viscous nanoflow resting on elastic foundation is investigated. Physical intuition reveals that increasing nanoscale stress leads to decrease the stiffness of nanostructure which firstly established by Eringen's non-local elasticity theory (previous nonlocal method) while many of papers have concluded otherwise at microscale based on modified couple stress, modified strain gradient theories and surface stress effect. The non-local higher order stress model (new nonlocal method) is used in this article that has been studied by few researchers in other fields and the results from the present study show that the trend of the new nonlocal method and size dependent effect including modified couple stress theory is the same. In this regard, the nonlinear motion equations are derived using a variational principal approach considering essential higher-order non-local terms. The surrounded elastic medium is modeled by Pasternak foundation to increase the stability of system where the fluid flow may cause system instability. Effects of various parameters such as non-local parameter, elastic foundation coefficient, and fluid flow velocity on the stability and dimensionless natural frequency of nanotube are investigated. The results of this research show that the small scale parameter based on higher order stress help to increase the natural frequency which has been approved by other small scale theories such as strain gradient theory, modified couple stress theory and experiments, and vice versa for previous nonlocal method. This study may be useful to measure accurately the vibration characteristics of nanotubes conveying viscous nanoflow and to design nanofluidic devices for detecting blood Glucose.

  1. The effect of non-local higher order stress to predict the nonlinear vibration behavior of carbon nanotube conveying viscous nanoflow

    Energy Technology Data Exchange (ETDEWEB)

    Mohammadimehr, M., E-mail: mmohammadimehr@kashanu.ac.ir [Department of Solid Mechanics, Faculty of Mechanical Engineering, University of Kashan, P.O. Box: 87317-53153, Kashan (Iran, Islamic Republic of); Mohammadi-Dehabadi, A.A. [Department of Solid Mechanics, Faculty of Mechanical Engineering, University of Kashan, P.O. Box: 87317-53153, Kashan (Iran, Islamic Republic of); Department of Mechanical Engineering, Iran University of Science and Technology, Narmak, Tehran (Iran, Islamic Republic of); Maraghi, Z. Khoddami [Department of Solid Mechanics, Faculty of Mechanical Engineering, University of Kashan, P.O. Box: 87317-53153, Kashan (Iran, Islamic Republic of)

    2017-04-01

    In this research, the effect of non-local higher order stress on the nonlinear vibration behavior of carbon nanotube conveying viscous nanoflow resting on elastic foundation is investigated. Physical intuition reveals that increasing nanoscale stress leads to decrease the stiffness of nanostructure which firstly established by Eringen's non-local elasticity theory (previous nonlocal method) while many of papers have concluded otherwise at microscale based on modified couple stress, modified strain gradient theories and surface stress effect. The non-local higher order stress model (new nonlocal method) is used in this article that has been studied by few researchers in other fields and the results from the present study show that the trend of the new nonlocal method and size dependent effect including modified couple stress theory is the same. In this regard, the nonlinear motion equations are derived using a variational principal approach considering essential higher-order non-local terms. The surrounded elastic medium is modeled by Pasternak foundation to increase the stability of system where the fluid flow may cause system instability. Effects of various parameters such as non-local parameter, elastic foundation coefficient, and fluid flow velocity on the stability and dimensionless natural frequency of nanotube are investigated. The results of this research show that the small scale parameter based on higher order stress help to increase the natural frequency which has been approved by other small scale theories such as strain gradient theory, modified couple stress theory and experiments, and vice versa for previous nonlocal method. This study may be useful to measure accurately the vibration characteristics of nanotubes conveying viscous nanoflow and to design nanofluidic devices for detecting blood Glucose.

  2. High order scheme for the non-local transport in ICF plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Feugeas, J.L.; Nicolai, Ph.; Schurtz, G. [Bordeaux-1 Univ., Centre Lasers Intenses et Applications (UMR 5107), 33 - Talence (France); Charrier, P.; Ahusborde, E. [Bordeaux-1 Univ., MAB, 33 - Talence (France)

    2006-06-15

    A high order practical scheme for a model of non-local transport is here proposed to be used in multidimensional radiation hydrodynamic codes. A high order scheme is necessary to solve non-local problems on strongly deformed meshes that are on hot point or ablation front zones. It is shown that the errors made by a classical 5 point scheme on a disturbed grid can be of the same order of magnitude as the non-local effects. The use of a 9 point scheme in a simulation of inertial confinement fusion appears to be essential.

  3. Exploring the brains of Baduk (Go experts: gray matter morphometry, resting-state functional connectivity, and graph theoretical analysis

    Directory of Open Access Journals (Sweden)

    Wi Hoon eJung

    2013-10-01

    Full Text Available One major characteristic of experts is intuitive judgment, which is an automatic process whereby patterns stored in memory through long-term training are recognized. Indeed, long-term training may influence brain structure and function. A recent study revealed that chess experts at rest showed differences in structure and functional connectivity (FC in the head of caudate, which is associated with rapid best next-move generation. However, less is known about the structure and function of the brains of Baduk experts compared with those of experts in other strategy games. Therefore, we performed voxel-based morphometry and FC analyses in Baduk experts to investigate structural brain differences and to clarify the influence of these differences on functional interactions. We also conducted graph theoretical analysis to explore the topological organization of whole-brain functional networks. Compared to novices, Baduk experts exhibited decreased and increased gray matter volume in the amygdala and nucleus accumbens, respectively. We also found increased FC between the amygdala and medial orbitofrontal cortex and decreased FC between the nucleus accumbens and medial prefrontal cortex. Further graph theoretical analysis revealed differences in measures of the integration of the network and in the regional nodal characteristics of various brain regions activated during Baduk. This study provides evidence for structural and functional differences as well as altered topological organization of the whole-brain functional networks in Baduk experts. Our findings also offer novel suggestions about the cognitive mechanisms behind Baduk expertise, which involves intuitive decision-making mediated by somatic marker circuitry and visuospatial processing.

  4. Robust spinal cord resting-state fMRI using independent component analysis-based nuisance regression noise reduction.

    Science.gov (United States)

    Hu, Yong; Jin, Richu; Li, Guangsheng; Luk, Keith Dk; Wu, Ed X

    2018-04-16

    Physiological noise reduction plays a critical role in spinal cord (SC) resting-state fMRI (rsfMRI). To reduce physiological noise and increase the robustness of SC rsfMRI by using an independent component analysis (ICA)-based nuisance regression (ICANR) method. Retrospective. Ten healthy subjects (female/male = 4/6, age = 27 ± 3 years, range 24-34 years). 3T/gradient-echo echo planar imaging (EPI). We used three alternative methods (no regression [Nil], conventional region of interest [ROI]-based noise reduction method without ICA [ROI-based], and correction of structured noise using spatial independent component analysis [CORSICA]) to compare with the performance of ICANR. Reduction of the influence of physiological noise on the SC and the reproducibility of rsfMRI analysis after noise reduction were examined. The correlation coefficient (CC) was calculated to assess the influence of physiological noise. Reproducibility was calculated by intraclass correlation (ICC). Results from different methods were compared by one-way analysis of variance (ANOVA) with post-hoc analysis. No significant difference in cerebrospinal fluid (CSF) pulsation influence or tissue motion influence were found (P = 0.223 in CSF, P = 0.2461 in tissue motion) in the ROI-based (CSF: 0.122 ± 0.020; tissue motion: 0.112 ± 0.015), and Nil (CSF: 0.134 ± 0.026; tissue motion: 0.124 ± 0.019). CORSICA showed a significantly stronger influence of CSF pulsation and tissue motion (CSF: 0.166 ± 0.045, P = 0.048; tissue motion: 0.160 ± 0.032, P = 0.048) than Nil. ICANR showed a significantly weaker influence of CSF pulsation and tissue motion (CSF: 0.076 ± 0.007, P = 0.0003; tissue motion: 0.081 ± 0.014, P = 0.0182) than Nil. The ICC values in the Nil, ROI-based, CORSICA, and ICANR were 0.669, 0.645, 0.561, and 0.766, respectively. ICANR more effectively reduced physiological noise from both tissue motion and CSF pulsation than three alternative methods. ICANR increases the robustness of SC rsf

  5. A hybrid local/non-local framework for the simulation of damage and fracture

    KAUST Repository

    Azdoud, Yan

    2014-01-01

    Recent advances in non-local continuum models, notably peridynamics, have spurred a paradigm shift in solid mechanics simulation by allowing accurate mathematical representation of singularities and discontinuities. This doctoral work attempts to extend the use of this theory to a community more familiar with local continuum models. In this communication, a coupling strategy - the morphing method -, which bridges local and non-local models, is presented. This thesis employs the morphing method to ease use of the non-local model to represent problems with failure-induced discontinuities. First, we give a quick review of strategies for the simulation of discrete degradation, and suggest a hybrid local/non-local alternative. Second, we present the technical concepts involved in the morphing method and evaluate the quality of the coupling. Third, we develop a numerical tool for the simulation of the hybrid model for fracture and damage and demonstrate its capabilities on numerical model examples

  6. REST based mobile applications

    Science.gov (United States)

    Rambow, Mark; Preuss, Thomas; Berdux, Jörg; Conrad, Marc

    2008-02-01

    Simplicity is the major advantage of REST based webservices. Whereas SOAP is widespread in complex, security sensitive business-to-business aplications, REST is widely used for mashups and end-user centric applicatons. In that context we give an overview of REST and compare it to SOAP. Furthermore we apply the GeoDrawing application as an example for REST based mobile applications and emphasize on pros and cons for the use of REST in mobile application scenarios.

  7. Observation of multi-channel non-local transport in J-TEXT plasmas

    Science.gov (United States)

    Shi, Yuejiang; Chen, Zhongyong; Yang, Zhoujun; Shi, Peng; Zhao, Kaijun; Diamond, Patrick H.; Kwon, JaeMin; Yan, Wei; Zhou, Hao; Pan, Xiaoming; Cheng, Zhifeng; Chen, Zhiping; Yang, SeongMoo; Zhang, Chi; Li, Da; Dong, Yunbo; Wang, Lu; Ding, YongHua; Liang, Yunfeng; Hahn, SangHee; Jhang, HoGun; Na, Yong-Su

    2018-04-01

    In cold pulse experiments in J-TEXT, not only are rapid electron temperature increases in the core observed, but also steep rises in the inner density are found. Moreover, some evidence of acceleration of the core toroidal rotation is also observed during the non-local transport process of electron temperature. These new findings of cold pulse experiments in J-TEXT suggest that turbulence spreading is a possible mechanism for the non-local transport dynamics.

  8. Off-shell t-matrix for an exponential potential with non-local core interaction

    International Nuclear Information System (INIS)

    Sarkar, S.B.; Talukdar, B.; Chattarji, D.

    1975-01-01

    The wave function approach of Van Leeuwen and Reiner to the t-matrix is generalized to the case of a non-local potential. The transition matrix element for this potential is obtained. The results are used to compute the s-wave part of the t-matrix for a non-local square well potential combined with an outside exponential potential. (Auth.)

  9. The Green’s functions for peridynamic non-local diffusion

    Science.gov (United States)

    Wang, L. J.; Xu, J. F.

    2016-01-01

    In this work, we develop the Green’s function method for the solution of the peridynamic non-local diffusion model in which the spatial gradient of the generalized potential in the classical theory is replaced by an integral of a generalized response function in a horizon. We first show that the general solutions of the peridynamic non-local diffusion model can be expressed as functionals of the corresponding Green’s functions for point sources, along with volume constraints for non-local diffusion. Then, we obtain the Green’s functions by the Fourier transform method for unsteady and steady diffusions in infinite domains. We also demonstrate that the peridynamic non-local solutions converge to the classical differential solutions when the non-local length approaches zero. Finally, the peridynamic analytical solutions are applied to an infinite plate heated by a Gauss source, and the predicted variations of temperature are compared with the classical local solutions. The peridynamic non-local diffusion model predicts a lower rate of variation of the field quantities than that of the classical theory, which is consistent with experimental observations. The developed method is applicable to general diffusion-type problems. PMID:27713658

  10. Positronium annihilation in liquids in the framework of non-local interaction

    International Nuclear Information System (INIS)

    Mukherjee, Tapas; Dutta, Dhanadeep

    2012-01-01

    In the bubble model of ortho positronium (o-Ps) annihilation in liquid the origin of the trapping of o-Ps is the electron-exchange repulsive interaction between the electron of o-Ps and the electron of the medium. The corresponding effective interaction is non-local in nature. However, in the prevalent bubble model, this effective interaction is usually treated as local (model) potential (sharp or smooth). In the present study, we have taken an approach to consider this trapping interaction as non-local in nature, which is included through a model separable non-local function to tackle the problem in analytically solvable manner. The analytical calculations show that this non-local interaction effectively acts as a gauge potential in the energy of the Ps atom in parameter (bubble radius) space. The computed bubble variables obtained using experimental Ps annihilation data are shown. A comparison between the present data with the calculated results using prevalent bubble model has been presented. Discussions have been made on the input parameter dependencies of the computed data. - Highlights: ► Bubble model has been modified by considering positronium-atom non-local interaction. ► No straight forward correlation between bubble size and effective potential is observed. ► Non-local potential acts as a guage potential.

  11. Quantitative circumferential strain analysis using adenosine triphosphate-stress/rest 3-T tagged magnetic resonance to evaluate regional contractile dysfunction in ischemic heart disease

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Masashi, E-mail: m.nakamura1230@gmail.com [Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon-city, Ehime 791-0295 (Japan); Kido, Tomoyuki [Department of Radiology, Saiseikai Matsuyama Hospital, Ehime 791-0295 (Japan); Kido, Teruhito; Tanabe, Yuki; Matsuda, Takuya; Nishiyama, Yoshiko; Miyagawa, Masao; Mochizuki, Teruhito [Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon-city, Ehime 791-0295 (Japan)

    2015-08-15

    Highlights: • Infarcted segments could be differentiated from non-ischemic and ischemic segments with high sensitivity and specificity under at rest conditions. • The time-to-peak circumferential strain values in infarcted segments were more significantly delayed than those in non-ischemic and ischemic segments. • Both circumferential strain and circumferential systolic strain rate values under ATP-stress conditions were significantly lower in ischemic segments than in non-ischemic segments. • Subtracting stress and rest circumferential strain had a higher diagnostic capability for ischemia relative to only utilizing rest or ATP-stress circumferential strain values. • A circumferential strain analysis using tagged MR can quantitatively assess contractile dysfunction in ischemic and infarcted myocardium. - Abstract: Purpose: We evaluated whether a quantitative circumferential strain (CS) analysis using adenosine triphosphate (ATP)-stress/rest 3-T tagged magnetic resonance (MR) imaging can depict myocardial ischemia as contractile dysfunction during stress in patients with suspected coronary artery disease (CAD). We evaluated whether it can differentiate between non-ischemia, myocardial ischemia, and infarction. We assessed its diagnostic performance in comparison with ATP-stress myocardial perfusion MR and late gadolinium enhancement (LGE)-MR imaging. Methods: In 38 patients suspected of having CAD, myocardial segments were categorized as non-ischemic (n = 485), ischemic (n = 74), or infarcted (n = 49) from the results of perfusion MR and LGE-MR. The peak negative CS value, peak circumferential systolic strain rate (CSR), and time-to-peak CS were measured in 16 segments. Results: A cutoff value of −12.0% for CS at rest allowed differentiation between infarcted and other segments with a sensitivity of 79%, specificity of 76%, accuracy of 76%, and an area under the curve (AUC) of 0.81. Additionally, a cutoff value of 477.3 ms for time-to-peak CS at rest

  12. Gene expression profiling of resting and activated vascular smooth muscle cells by serial analysis of gene expression and clustering analysis

    NARCIS (Netherlands)

    Beauchamp, Nicholas J.; van Achterberg, Tanja A. E.; Engelse, Marten A.; Pannekoek, Hans; de Vries, Carlie J. M.

    2003-01-01

    Migration and proliferation of vascular smooth muscle cells (SMCs) are key events in atherosclerosis. However, little is known about alterations in gene expression upon transition of the quiescent, contractile SMC to the proliferative SMC. We performed serial analysis of gene expression (SAGE) of

  13. Network analysis of functional brain connectivity in borderline personality disorder using resting-state fMRI.

    Science.gov (United States)

    Xu, Tingting; Cullen, Kathryn R; Mueller, Bryon; Schreiner, Mindy W; Lim, Kelvin O; Schulz, S Charles; Parhi, Keshab K

    2016-01-01

    Borderline personality disorder (BPD) is associated with symptoms such as affect dysregulation, impaired sense of self, and self-harm behaviors. Neuroimaging research on BPD has revealed structural and functional abnormalities in specific brain regions and connections. However, little is known about the topological organizations of brain networks in BPD. We collected resting-state functional magnetic resonance imaging (fMRI) data from 20 patients with BPD and 10 healthy controls, and constructed frequency-specific functional brain networks by correlating wavelet-filtered fMRI signals from 82 cortical and subcortical regions. We employed graph-theory based complex network analysis to investigate the topological properties of the brain networks, and employed network-based statistic to identify functional dysconnections in patients. In the 0.03-0.06 Hz frequency band, compared to controls, patients with BPD showed significantly larger measures of global network topology, including the size of largest connected graph component, clustering coefficient, small-worldness, and local efficiency, indicating increased local cliquishness of the functional brain network. Compared to controls, patients showed lower nodal centrality at several hub nodes but greater centrality at several non-hub nodes in the network. Furthermore, an interconnected subnetwork in 0.03-0.06 Hz frequency band was identified that showed significantly lower connectivity in patients. The links in the subnetwork were mainly long-distance connections between regions located at different lobes; and the mean connectivity of this subnetwork was negatively correlated with the increased global topology measures. Lastly, the key network measures showed high correlations with several clinical symptom scores, and classified BPD patients against healthy controls with high accuracy based on linear discriminant analysis. The abnormal topological properties and connectivity found in this study may add new knowledge

  14. Network analysis of functional brain connectivity in borderline personality disorder using resting-state fMRI

    Directory of Open Access Journals (Sweden)

    Tingting Xu

    2016-01-01

    Full Text Available Borderline personality disorder (BPD is associated with symptoms such as affect dysregulation, impaired sense of self, and self-harm behaviors. Neuroimaging research on BPD has revealed structural and functional abnormalities in specific brain regions and connections. However, little is known about the topological organizations of brain networks in BPD. We collected resting-state functional magnetic resonance imaging (fMRI data from 20 patients with BPD and 10 healthy controls, and constructed frequency-specific functional brain networks by correlating wavelet-filtered fMRI signals from 82 cortical and subcortical regions. We employed graph-theory based complex network analysis to investigate the topological properties of the brain networks, and employed network-based statistic to identify functional dysconnections in patients. In the 0.03–0.06 Hz frequency band, compared to controls, patients with BPD showed significantly larger measures of global network topology, including the size of largest connected graph component, clustering coefficient, small-worldness, and local efficiency, indicating increased local cliquishness of the functional brain network. Compared to controls, patients showed lower nodal centrality at several hub nodes but greater centrality at several non-hub nodes in the network. Furthermore, an interconnected subnetwork in 0.03–0.06 Hz frequency band was identified that showed significantly lower connectivity in patients. The links in the subnetwork were mainly long-distance connections between regions located at different lobes; and the mean connectivity of this subnetwork was negatively correlated with the increased global topology measures. Lastly, the key network measures showed high correlations with several clinical symptom scores, and classified BPD patients against healthy controls with high accuracy based on linear discriminant analysis. The abnormal topological properties and connectivity found in this study

  15. AN ANALYSIS OF HATCHLING RESTING METABOLISM - IN SEARCH OF ECOLOGICAL CORRELATES THAT EXPLAIN DEVIATIONS FROM ALLOMETRIC RELATIONS

    NARCIS (Netherlands)

    KLAASSEN, M; DRENT, R

    From data in the literature, an allometric equation is compiled for hatchling resting metabolic rate and an attempt is made to explain residual variation in terms of hatchling type, yolk and water content, embryonic and postnatal growth rate, and environmental circumstances (latitudinal

  16. Mapping the brain correlates of borderline personality disorder: A functional neuroimaging meta-analysis of resting state studies.

    Science.gov (United States)

    Visintin, Eleonora; De Panfilis, Chiara; Amore, Mario; Balestrieri, Matteo; Wolf, Robert Christian; Sambataro, Fabio

    2016-11-01

    Altered intrinsic function of the brain has been implicated in Borderline Personality Disorder (BPD). Nonetheless, imaging studies have yielded inconsistent alterations of brain function. To investigate the neural activity at rest in BPD, we conducted a set of meta-analyses of brain imaging studies performed at rest. A total of seven functional imaging studies (152 patients with BPD and 147 control subjects) were combined using whole-brain Signed Differential Mapping meta-analyses. Furthermore, two conjunction meta-analyses of neural activity at rest were also performed: with neural activity changes during emotional processing, and with structural differences, respectively. We found altered neural activity in the regions of the default mode network (DMN) in BPD. Within the regions of the midline core DMN, patients with BPD showed greater activity in the anterior as well as in the posterior midline hubs relative to controls. Conversely, in the regions of the dorsal DMN they showed reduced activity compared to controls in the right lateral temporal complex and bilaterally in the orbitofrontal cortex. Increased activity in the precuneus was observed both at rest and during emotional processing. Reduced neural activity at rest in lateral temporal complex was associated with smaller volume of this area. Heterogeneity across imaging studies. Altered activity in the regions of the midline core as well as of the dorsal subsystem of the DMN may reflect difficulties with interpersonal and affective regulation in BPD. These findings suggest that changes in spontaneous neural activity could underlie core symptoms in BPD. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Exploring the "what if?" in geology through a RESTful open-source framework for cloud-based simulation and analysis

    Science.gov (United States)

    Klump, Jens; Robertson, Jess

    2016-04-01

    The spatial and temporal extent of geological phenomena makes experiments in geology difficult to conduct, if not entirely impossible and collection of data is laborious and expensive - so expensive that most of the time we cannot test a hypothesis. The aim, in many cases, is to gather enough data to build a predictive geological model. Even in a mine, where data are abundant, a model remains incomplete because the information at the level of a blasting block is two orders of magnitude larger than the sample from a drill core, and we have to take measurement errors into account. So, what confidence can we have in a model based on sparse data, uncertainties and measurement error? Our framework consist of two layers: (a) a ground-truth layer that contains geological models, which can be statistically based on historical operations data, and (b) a network of RESTful synthetic sensor microservices which can query the ground-truth for underlying properties and produce a simulated measurement to a control layer, which could be a database or LIMS, a machine learner or a companies' existing data infrastructure. Ground truth data are generated by an implicit geological model which serves as a host for nested models of geological processes as smaller scales. Our two layers are implemented using Flask and Gunicorn, which are open source Python web application framework and server, the PyData stack (numpy, scipy etc) and Rabbit MQ (an open-source queuing library). Sensor data is encoded using a JSON-LD version of the SensorML and Observations and Measurements standards. Containerisation of the synthetic sensors using Docker and CoreOS allows rapid and scalable deployment of large numbers of sensors, as well as sensor discovery to form a self-organized dynamic network of sensors. Real-time simulation of data sources can be used to investigate crucial questions such as the potential information gain from future sensing capabilities, or from new sampling strategies, or the

  18. Resting-State Functional Connectivity and Network Analysis of Cerebellum with Respect to Crystallized IQ and Gender.

    Science.gov (United States)

    Pezoulas, Vasileios C; Zervakis, Michalis; Michelogiannis, Sifis; Klados, Manousos A

    2017-01-01

    During the last years, it has been established that the prefrontal and posterior parietal brain lobes, which are mostly related to intelligence, have many connections to cerebellum. However, there is a limited research investigating cerebellum's relationship with cognitive processes. In this study, the network of cerebellum was analyzed in order to investigate its overall organization in individuals with low and high crystallized Intelligence Quotient (IQ). Functional magnetic resonance imaging (fMRI) data were selected from 136 subjects in resting-state from the Human Connectome Project (HCP) database and were further separated into two IQ groups composed of 69 low-IQ and 67 high-IQ subjects. Cerebellum was parcellated into 28 lobules/ROIs (per subject) using a standard cerebellum anatomical atlas. Thereafter, correlation matrices were constructed by computing Pearson's correlation coefficients between the average BOLD time-series for each pair of ROIs inside the cerebellum. By computing conventional graph metrics, small-world network properties were verified using the weighted clustering coefficient and the characteristic path length for estimating the trade-off between segregation and integration. In addition, a connectivity metric was computed for extracting the average cost per network. The concept of the Minimum Spanning Tree (MST) was adopted and implemented in order to avoid methodological biases in graph comparisons and retain only the strongest connections per network. Subsequently, six global and three local metrics were calculated in order to retrieve useful features concerning the characteristics of each MST. Moreover, the local metrics of degree and betweenness centrality were used to detect hubs, i.e., nodes with high importance. The computed set of metrics gave rise to extensive statistical analysis in order to examine differences between low and high-IQ groups, as well as between all possible gender-based group combinations. Our results reveal that

  19. Resting-State Functional Connectivity and Network Analysis of Cerebellum with Respect to Crystallized IQ and Gender

    Directory of Open Access Journals (Sweden)

    Vasileios C. Pezoulas

    2017-04-01

    Full Text Available During the last years, it has been established that the prefrontal and posterior parietal brain lobes, which are mostly related to intelligence, have many connections to cerebellum. However, there is a limited research investigating cerebellum's relationship with cognitive processes. In this study, the network of cerebellum was analyzed in order to investigate its overall organization in individuals with low and high crystallized Intelligence Quotient (IQ. Functional magnetic resonance imaging (fMRI data were selected from 136 subjects in resting-state from the Human Connectome Project (HCP database and were further separated into two IQ groups composed of 69 low-IQ and 67 high-IQ subjects. Cerebellum was parcellated into 28 lobules/ROIs (per subject using a standard cerebellum anatomical atlas. Thereafter, correlation matrices were constructed by computing Pearson's correlation coefficients between the average BOLD time-series for each pair of ROIs inside the cerebellum. By computing conventional graph metrics, small-world network properties were verified using the weighted clustering coefficient and the characteristic path length for estimating the trade-off between segregation and integration. In addition, a connectivity metric was computed for extracting the average cost per network. The concept of the Minimum Spanning Tree (MST was adopted and implemented in order to avoid methodological biases in graph comparisons and retain only the strongest connections per network. Subsequently, six global and three local metrics were calculated in order to retrieve useful features concerning the characteristics of each MST. Moreover, the local metrics of degree and betweenness centrality were used to detect hubs, i.e., nodes with high importance. The computed set of metrics gave rise to extensive statistical analysis in order to examine differences between low and high-IQ groups, as well as between all possible gender-based group combinations. Our

  20. Non-local Fast Extraction from the CERN SPS at 100 and 440 GeV

    CERN Document Server

    Velotti, F M; Bartmann, W; Carlier, E; Cornelis, K; Efthymiopoulos, I; Goddard, B; Jensen, L K; Kain, V; Kowalska, M; Mertens, V; Steerenberg, R

    2013-01-01

    The Long Straight Section 2 (LSS2) of the CERN SPS is connected with the North Area (NA), to which the beam to date has always been extracted using a resonant extraction technique. For new proposed short- and long-baseline neutrino experiments, a fast single turn extraction to this experimental area is required. As there are no kickers in LSS2, and the integration of any new kickers with the existing electrostatic septum would be problematic, a solution has been developed to fast extract the beam using non-local extraction with other SPS kickers. Two different kicker systems have been used, the injection kicker in LSS1 and the stronger extraction kicker in LSS6 to extract 100 and 440 GeV beam, respectively. For both solutions a large emittance beam was extracted after 5 or 9 full betatron periods. The concept and simulation details are presented with the analysis of the aperture and beam loss considerations and experimental results collected during a series of beam tests.

  1. Correcting for Blood Arrival Time in Global Mean Regression Enhances Functional Connectivity Analysis of Resting State fMRI-BOLD Signals.

    Science.gov (United States)

    Erdoğan, Sinem B; Tong, Yunjie; Hocke, Lia M; Lindsey, Kimberly P; deB Frederick, Blaise

    2016-01-01

    Resting state functional connectivity analysis is a widely used method for mapping intrinsic functional organization of the brain. Global signal regression (GSR) is commonly employed for removing systemic global variance from resting state BOLD-fMRI data; however, recent studies have demonstrated that GSR may introduce spurious negative correlations within and between functional networks, calling into question the meaning of anticorrelations reported between some networks. In the present study, we propose that global signal from resting state fMRI is composed primarily of systemic low frequency oscillations (sLFOs) that propagate with cerebral blood circulation throughout the brain. We introduce a novel systemic noise removal strategy for resting state fMRI data, "dynamic global signal regression" (dGSR), which applies a voxel-specific optimal time delay to the global signal prior to regression from voxel-wise time series. We test our hypothesis on two functional systems that are suggested to be intrinsically organized into anticorrelated networks: the default mode network (DMN) and task positive network (TPN). We evaluate the efficacy of dGSR and compare its performance with the conventional "static" global regression (sGSR) method in terms of (i) explaining systemic variance in the data and (ii) enhancing specificity and sensitivity of functional connectivity measures. dGSR increases the amount of BOLD signal variance being modeled and removed relative to sGSR while reducing spurious negative correlations introduced in reference regions by sGSR, and attenuating inflated positive connectivity measures. We conclude that incorporating time delay information for sLFOs into global noise removal strategies is of crucial importance for optimal noise removal from resting state functional connectivity maps.

  2. The effects of relativistic and non-local non-linearities on modulational instabilities in non-uniform plasma

    International Nuclear Information System (INIS)

    Mohamed, B.F.; El-Shorbagy, Kh.H.

    2000-01-01

    A general detailed analysis for the nonlinear generation of localized fields due to the existence of a strong pump field inside the non-uniform plasma has been considered. We have taken into account the effects of relativistic and non-local nonlinearities on the structure of plasma resonance region. The nonlinear Schrodinger equation described the localized fields are investigated. Besides, the generalized dispersion relation is obtained to study the modulational instabilities in different cases. Keywords: Wave-plasma interaction, Nonlinear effects, Modulation instabilities

  3. Resting-State Seed-Based Analysis: An Alternative to Task-Based Language fMRI and Its Laterality Index.

    Science.gov (United States)

    Smitha, K A; Arun, K M; Rajesh, P G; Thomas, B; Kesavadas, C

    2017-06-01

    Language is a cardinal function that makes human unique. Preservation of language function poses a great challenge for surgeons during resection. The aim of the study was to assess the efficacy of resting-state fMRI in the lateralization of language function in healthy subjects to permit its further testing in patients who are unable to perform task-based fMRI. Eighteen healthy right-handed volunteers were prospectively evaluated with resting-state fMRI and task-based fMRI to assess language networks. The laterality indices of Broca and Wernicke areas were calculated by using task-based fMRI via a voxel-value approach. We adopted seed-based resting-state fMRI connectivity analysis together with parameters such as amplitude of low-frequency fluctuation and fractional amplitude of low-frequency fluctuation (fALFF). Resting-state fMRI connectivity maps for language networks were obtained from Broca and Wernicke areas in both hemispheres. We performed correlation analysis between the laterality index and the z scores of functional connectivity, amplitude of low-frequency fluctuation, and fALFF. Pearson correlation analysis between signals obtained from the z score of fALFF and the laterality index yielded a correlation coefficient of 0.849 ( P laterality index yielded an R 2 value of 0.721, indicating that 72.1% of the variance in the laterality index of task-based fMRI could be predicted from the fALFF of resting-state fMRI. The present study demonstrates that fALFF can be used as an alternative to task-based fMRI for assessing language laterality. There was a strong positive correlation between the fALFF of the Broca area of resting-state fMRI with the laterality index of task-based fMRI. Furthermore, we demonstrated the efficacy of fALFF for predicting the laterality of task-based fMRI. © 2017 by American Journal of Neuroradiology.

  4. Alternative REST Splicing Underappreciated

    OpenAIRE

    Chen, Guo-Lin; Miller, Gregory

    2017-01-01

    As a major orchestrator of the cellular epigenome, the repressor element-1 silencing transcription factor (REST) can either repress or activate thousands of genes depending on cellular context, suggesting a highly context-dependent REST function tuned by environmental cues. While REST shows cell-type non-selective active transcription, an N-terminal REST4 isoform caused by alternative splicing - inclusion of an extra exon (N3c) which introduces a pre-mature stop codon - has been implicated in...

  5. Network analysis of functional brain connectivity in borderline personality disorder using resting-state fMRI

    OpenAIRE

    Tingting Xu; Kathryn R. Cullen; Bryon Mueller; Mindy W. Schreiner; Kelvin O. Lim; S. Charles Schulz; Keshab K. Parhi

    2016-01-01

    Borderline personality disorder (BPD) is associated with symptoms such as affect dysregulation, impaired sense of self, and self-harm behaviors. Neuroimaging research on BPD has revealed structural and functional abnormalities in specific brain regions and connections. However, little is known about the topological organizations of brain networks in BPD. We collected resting-state functional magnetic resonance imaging (fMRI) data from 20 patients with BPD and 10 healthy controls, and construc...

  6. On the non-local obstruction to interacting higher spins in flat space

    Energy Technology Data Exchange (ETDEWEB)

    Taronna, Massimo [Physique Théorique et Mathématique,Université Libre de Bruxelles and International Solvay Institutes,ULB-Campus Plaine CP231, 1050 Brussels (Belgium)

    2017-05-04

    Owing to a renewed interest in flat space higher spin gauge theories, in this note we provide further details and clarifications on the results presented in arXiv:1107.5843 and arXiv: 1209.5755, which investigated their locality properties. Focusing, for simplicity, on quartic couplings with one of the external legs having non-zero integer spin (which can be considered as a prototype for Weinberg-type arguments), we review the appearance of 1/◻ non-localities. In particular, we emphasise that it appears to be not possible to eliminate all of the aforementioned non-localities in the general quartic Noether procedure solution with a judicious choice of coupling constants and spectrum. We also discuss the light-cone gauge fixing in d=4, and argue that the non-local obstruction discussed in the covariant language cannot be avoided using light-cone gauge formalism.

  7. Non-local spatial frequency response of photopolymer materials containing chain transfer agents: I. Theoretical modelling

    International Nuclear Information System (INIS)

    Guo, Jinxin; Gleeson, Michael R; Liu, Shui; Sheridan, John T

    2011-01-01

    The non-local photopolymerization driven diffusion (NPDD) model predicts that a reduction in the non-local response length within a photopolymer material will improve its high spatial frequency response. The introduction of a chain transfer agent reduces the average molecular weight of polymer chains formed during free radical polymerization. Therefore a chain transfer agent (CTA) provides a practical method to reduce the non-local response length. An extended NPDD model is presented, which includes the chain transfer reaction and most major photochemical processes. The addition of a chain transfer agent into an acrylamide/polyvinyl alcohol photopolymer material is simulated and the predictions of the model are examined. The predictions of the model are experimentally examined in part II of this paper

  8. Purely non-local Hamiltonian formalism, Kohno connections and ∨-systems

    International Nuclear Information System (INIS)

    Arsie, Alessandro; Lorenzoni, Paolo

    2014-01-01

    In this paper, we extend purely non-local Hamiltonian formalism to a class of Riemannian F-manifolds, without assumptions on the semisimplicity of the product ○ or on the flatness of the connection ∇. In the flat case, we show that the recurrence relations for the principal hierarchy can be re-interpreted using a local and purely non-local Hamiltonian operators and in this case they split into two Lenard-Magri chains, one involving the even terms, the other involving the odd terms. Furthermore, we give an elementary proof that the Kohno property and the ∨-system condition are equivalent under suitable assumptions and we show how to associate a purely non-local Hamiltonian structure to any ∨-system, including degenerate ones

  9. Non-local two phase flow momentum transport in S BWR

    International Nuclear Information System (INIS)

    Espinosa P, G.; Salinas M, L.; Vazquez R, A.

    2015-09-01

    The non-local momentum transport equations derived in this work contain new terms related with non-local transport effects due to accumulation, convection, diffusion and transport properties for two-phase flow. For instance, they can be applied in the boundary between a two-phase flow and a solid phase, or in the boundary of the transition region of two-phase flows where the local volume averaging equations fail. The S BWR was considered to study the non-local effects on the two-phase flow thermal-hydraulic core performance in steady-state, and the results were compared with the classical local averaging volume conservation equations. (Author)

  10. Effect of the interface resistance in non-local Hanle measurements

    International Nuclear Information System (INIS)

    Villamor, Estitxu; Hueso, Luis E.; Casanova, Fèlix

    2015-01-01

    We use lateral spin valves with varying interface resistance to measure non-local Hanle effect in order to extract the spin-diffusion length of the non-magnetic channel. A general expression that describes spin injection and transport, taking into account the influence of the interface resistance, is used to fit our results. Whereas the fitted spin-diffusion length value is in agreement with the one obtained from standard non-local measurements in the case of a finite interface resistance, in the case of transparent contacts a clear disagreement is observed. The use of a corrected expression, recently proposed to account for the anisotropy of the spin absorption at the ferromagnetic electrodes, still yields a deviation of the fitted spin-diffusion length which increases for shorter channel distances. This deviation shows how sensitive the non-local Hanle fittings are, evidencing the complexity of obtaining spin transport information from such type of measurements

  11. Instantaneous Non-Local Computation of Low T-Depth Quantum Circuits

    DEFF Research Database (Denmark)

    Speelman, Florian

    2016-01-01

    -depth of a quantum circuit, able to perform non-local computation of quantum circuits with a (poly-)logarithmic number of layers of T gates with quasi-polynomial entanglement. Our proofs combine ideas from blind and delegated quantum computation with the garden-hose model, a combinatorial model of communication......Instantaneous non-local quantum computation requires multiple parties to jointly perform a quantum operation, using pre-shared entanglement and a single round of simultaneous communication. We study this task for its close connection to position-based quantum cryptography, but it also has natural...... applications in the context of foundations of quantum physics and in distributed computing. The best known general construction for instantaneous non-local quantum computation requires a pre-shared state which is exponentially large in the number of qubits involved in the operation, while efficient...

  12. The status and prospects of quantum non-local field theory

    International Nuclear Information System (INIS)

    Cornish, N.J.; Melbourne Univ., Parkville

    1991-01-01

    A critical review of the physical constraints on the form the non-locality can take is presented. The conclusion of this review is that non-locality must be restricted to interactions with the vacuum sea of virtual particles. A successful formulation of such a theory, Quantum Nonlocal Field Theory (QNFT), is applied to scalar electrodynamics and serves to illustrate how gauge invariance and manifest finiteness can be achieved. The importance of the infinite dimensional symmetry groups that occur in QNFT are discussed as an alternative to supersymmetry, the ability to generate masses by breaking the non-local symmetry with a non-invariant functional measure is given a critical assessment. To demonstrate some of the many novel applications QNFT may make possible, three disparate examples are mooted, the existence of electroweak monopoles, an mechanism for CP violation and the formulation of a finite perturbative theory of Quantum Gravity. 21 refs., ills

  13. Extended non-local games and monogamy-of-entanglement games.

    Science.gov (United States)

    Johnston, Nathaniel; Mittal, Rajat; Russo, Vincent; Watrous, John

    2016-05-01

    We study a generalization of non-local games-which we call extended non-local games -in which the players, Alice and Bob, initially share a tripartite quantum state with the referee. In such games, the winning conditions for Alice and Bob may depend on the outcomes of measurements made by the referee, on its part of the shared quantum state, in addition to Alice and Bob's answers to randomly selected questions. Our study of this class of games was inspired by the monogamy-of-entanglement games introduced by Tomamichel, Fehr, Kaniewski and Wehner, which they also generalize. We prove that a natural extension of the Navascués-Pironio-Acín hierarchy of semidefinite programmes converges to the optimal commuting measurement value of extended non-local games, and we prove two extensions of results of Tomamichel et al.  concerning monogamy-of-entanglement games.

  14. Non-local two phase flow momentum transport in S BWR

    Energy Technology Data Exchange (ETDEWEB)

    Espinosa P, G.; Salinas M, L.; Vazquez R, A., E-mail: gepe@xanum.uam.mx [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Area de Ingenieria en Recursos Energeticos, Apdo. Postal 55-535, 09340 Ciudad de Mexico (Mexico)

    2015-09-15

    The non-local momentum transport equations derived in this work contain new terms related with non-local transport effects due to accumulation, convection, diffusion and transport properties for two-phase flow. For instance, they can be applied in the boundary between a two-phase flow and a solid phase, or in the boundary of the transition region of two-phase flows where the local volume averaging equations fail. The S BWR was considered to study the non-local effects on the two-phase flow thermal-hydraulic core performance in steady-state, and the results were compared with the classical local averaging volume conservation equations. (Author)

  15. Mutual Connectivity Analysis (MCA) Using Generalized Radial Basis Function Neural Networks for Nonlinear Functional Connectivity Network Recovery in Resting-State Functional MRI.

    Science.gov (United States)

    DSouza, Adora M; Abidin, Anas Zainul; Nagarajan, Mahesh B; Wismüller, Axel

    2016-03-29

    We investigate the applicability of a computational framework, called mutual connectivity analysis (MCA), for directed functional connectivity analysis in both synthetic and resting-state functional MRI data. This framework comprises of first evaluating non-linear cross-predictability between every pair of time series prior to recovering the underlying network structure using community detection algorithms. We obtain the non-linear cross-prediction score between time series using Generalized Radial Basis Functions (GRBF) neural networks. These cross-prediction scores characterize the underlying functionally connected networks within the resting brain, which can be extracted using non-metric clustering approaches, such as the Louvain method. We first test our approach on synthetic models with known directional influence and network structure. Our method is able to capture the directional relationships between time series (with an area under the ROC curve = 0.92 ± 0.037) as well as the underlying network structure (Rand index = 0.87 ± 0.063) with high accuracy. Furthermore, we test this method for network recovery on resting-state fMRI data, where results are compared to the motor cortex network recovered from a motor stimulation sequence, resulting in a strong agreement between the two (Dice coefficient = 0.45). We conclude that our MCA approach is effective in analyzing non-linear directed functional connectivity and in revealing underlying functional network structure in complex systems.

  16. Geometrically nonlinear dynamic analysis of doubly curved isotropic shells resting on elastic foundation by a combination of harmonic differential quadrature-finite difference methods

    International Nuclear Information System (INIS)

    Civalek, Oemer

    2005-01-01

    The nonlinear dynamic response of doubly curved shallow shells resting on Winkler-Pasternak elastic foundation has been studied for step and sinusoidal loadings. Dynamic analogues of Von Karman-Donnel type shell equations are used. Clamped immovable and simply supported immovable boundary conditions are considered. The governing nonlinear partial differential equations of the shell are discretized in space and time domains using the harmonic differential quadrature (HDQ) and finite differences (FD) methods, respectively. The accuracy of the proposed HDQ-FD coupled methodology is demonstrated by numerical examples. The shear parameter G of the Pasternak foundation and the stiffness parameter K of the Winkler foundation have been found to have a significant influence on the dynamic response of the shell. It is concluded from the present study that the HDQ-FD methodolgy is a simple, efficient, and accurate method for the nonlinear analysis of doubly curved shallow shells resting on two-parameter elastic foundation

  17. Chimera states and the interplay between initial conditions and non-local coupling

    Science.gov (United States)

    Kalle, Peter; Sawicki, Jakub; Zakharova, Anna; Schöll, Eckehard

    2017-03-01

    Chimera states are complex spatio-temporal patterns that consist of coexisting domains of coherent and incoherent dynamics. We study chimera states in a network of non-locally coupled Stuart-Landau oscillators. We investigate the impact of initial conditions in combination with non-local coupling. Based on an analytical argument, we show how the coupling phase and the coupling strength are linked to the occurrence of chimera states, flipped profiles of the mean phase velocity, and the transition from a phase- to an amplitude-mediated chimera state.

  18. Importance of non-local electron-positron correlations for positron annihilation characteristics in solids

    International Nuclear Information System (INIS)

    Rubaszek, A.

    2001-01-01

    Several methods to describe the electron-positron (e-p) correlation effects are used in calculations of positron annihilation characteristics in solids. The weighted density approximation (WDA), giving rise to the non-local, state-selective e-p correlation functions, is applied to calculate positron annihilation rates and e-p momentum densities in a variety of metals and silicon. The WDA results are compared to the results of other methods such as the independent particle model, local density approximation, generalised gradient approximation, and also to experiments. The importance of non-locality and state-dependence of the e-p correlation functions is discussed. (orig.)

  19. Modeling non-locality of plasmonic excitations with a fictitious film

    Science.gov (United States)

    Kong, Jiantao; Shvonski, Alexander; Kempa, Krzysztof

    Non-local effects, requiring a wavevector (q) dependent dielectric response are becoming increasingly important in studies of plasmonic and metamaterial structures. The phenomenological hydrodynamic approximation (HDA) is the simplest, and most often used model, but it often fails. We show that the d-function formalism, exact to first order in q, is a powerful and simple-to-use alternative. Recently, we developed a mapping of the d-function formalism into a purely local fictitious film. This geometric mapping allows for non-local extensions of any local calculation scheme, including FDTD. We demonstrate here, that such mapped FDTD simulation of metallic nanoclusters agrees very well with various experiments.

  20. On monogamy of non-locality and macroscopic averages: examples and preliminary results

    Directory of Open Access Journals (Sweden)

    Rui Soares Barbosa

    2014-12-01

    Full Text Available We explore a connection between monogamy of non-locality and a weak macroscopic locality condition: the locality of the average behaviour. These are revealed by our analysis as being two sides of the same coin. Moreover, we exhibit a structural reason for both in the case of Bell-type multipartite scenarios, shedding light on but also generalising the results in the literature [Ramanathan et al., Phys. Rev. Lett. 107, 060405 (2001; Pawlowski & Brukner, Phys. Rev. Lett. 102, 030403 (2009]. More specifically, we show that, provided the number of particles in each site is large enough compared to the number of allowed measurement settings, and whatever the microscopic state of the system, the macroscopic average behaviour is local realistic, or equivalently, general multipartite monogamy relations hold. This result relies on a classical mathematical theorem by Vorob'ev [Theory Probab. Appl. 7(2, 147-163 (1962] about extending compatible families of probability distributions defined on the faces of a simplicial complex – in the language of the sheaf-theoretic framework of Abramsky & Brandenburger [New J. Phys. 13, 113036 (2011], such families correspond to no-signalling empirical models, and the existence of an extension corresponds to locality or non-contextuality. Since Vorob'ev's theorem depends solely on the structure of the simplicial complex, which encodes the compatibility of the measurements, and not on the specific probability distributions (i.e. the empirical models, our result about monogamy relations and locality of macroscopic averages holds not just for quantum theory, but for any empirical model satisfying the no-signalling condition. In this extended abstract, we illustrate our approach by working out a couple of examples, which convey the intuition behind our analysis while keeping the discussion at an elementary level.

  1. Global and system-specific resting-state fMRI fluctuations are uncorrelated: principal component analysis reveals anti-correlated networks.

    Science.gov (United States)

    Carbonell, Felix; Bellec, Pierre; Shmuel, Amir

    2011-01-01

    The influence of the global average signal (GAS) on functional-magnetic resonance imaging (fMRI)-based resting-state functional connectivity is a matter of ongoing debate. The global average fluctuations increase the correlation between functional systems beyond the correlation that reflects their specific functional connectivity. Hence, removal of the GAS is a common practice for facilitating the observation of network-specific functional connectivity. This strategy relies on the implicit assumption of a linear-additive model according to which global fluctuations, irrespective of their origin, and network-specific fluctuations are super-positioned. However, removal of the GAS introduces spurious negative correlations between functional systems, bringing into question the validity of previous findings of negative correlations between fluctuations in the default-mode and the task-positive networks. Here we present an alternative method for estimating global fluctuations, immune to the complications associated with the GAS. Principal components analysis was applied to resting-state fMRI time-series. A global-signal effect estimator was defined as the principal component (PC) that correlated best with the GAS. The mean correlation coefficient between our proposed PC-based global effect estimator and the GAS was 0.97±0.05, demonstrating that our estimator successfully approximated the GAS. In 66 out of 68 runs, the PC that showed the highest correlation with the GAS was the first PC. Since PCs are orthogonal, our method provides an estimator of the global fluctuations, which is uncorrelated to the remaining, network-specific fluctuations. Moreover, unlike the regression of the GAS, the regression of the PC-based global effect estimator does not introduce spurious anti-correlations beyond the decrease in seed-based correlation values allowed by the assumed additive model. After regressing this PC-based estimator out of the original time-series, we observed robust anti

  2. Analysis of Crystal Barrel data on the reaction p-barp annihilation at rest into π+π-π0η

    International Nuclear Information System (INIS)

    Matveev, M.

    2004-01-01

    The preliminary results of partial wave analysis of the Crystal Barrel data on p-barp annihilation at rest into π+π-π0η are presented. The data provide the information about production of meson channels, such as b1π, h1η from 1S0 and 3S1 p-barp state annihilation. The analysis shows the presence of the b 1 * resonance and a possible presence of ρ2 in the mass region around 1600 MeV. The mass of b 1 * was found to be 1620 ± 15 MeV

  3. Relative influence of age, resting heart rate and sedentary life style in short-term analysis of heart rate variability

    OpenAIRE

    E.R. Migliaro; P. Contreras; S. Bech; A. Etxagibel; M. Castro; R. Ricca; K. Vicente

    2001-01-01

    In order to assess the relative influence of age, resting heart rate (HR) and sedentary life style, heart rate variability (HRV) was studied in two different groups. The young group (YG) consisted of 9 sedentary subjects aged 15 to 20 years (YG-S) and of 9 nonsedentary volunteers (YG-NS) also aged 15 to 20. The elderly sedentary group (ESG) consisted of 16 sedentary subjects aged 39 to 82 years. HRV was assessed using a short-term procedure (5 min). R-R variability was calculated in the time-...

  4. Development of brain synchronisation within school-age--individual analysis of resting (α) coherence in a longitudinal data set.

    Science.gov (United States)

    Gmehlin, Dennis; Thomas, Christine; Weisbrod, Matthias; Walther, Stephan; Resch, Franz; Oelkers-Ax, Rieke

    2011-10-01

    Given evidence that synchronisation of neuronal activity may be a correlate of cognition, we examined EEG coherence as function of age and inter-electrode distance in healthy children and adolescents in order to elucidate basic information for a better understanding of developmental disorders associated with deficits in cognitive functions. Based on a 64-channel eyes closed resting EEG we combined local and global coherence measures in order to reduce volume conduction and reference effects. We used a two point longitudinal design in order to analyze intraindividual change during school-age (n=40; 6-18 years). Coherence was analyzed within individually adjusted frequency bands and around iPF (= individual alpha peak frequency). Both local and global resting coherence was largest in the alpha range and particularly around iPF. Local synchronisation was larger in the left compared with the right hemisphere. Controlling for increases in iPF, synchronisation increased with age, with global changes being most pronounced in the alpha range. Moreover age-related changes suggest an earlier development in girls. Our data provides evidence that both local and global functional integration increases during normal development within school-age. This general pattern - combined with more specific effects of sex and frequency - may help to specify deviations in developmental disorders. Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  5. Experimental benchmark of non-local-thermodynamic-equilibrium plasma atomic physics codes

    International Nuclear Information System (INIS)

    Nagels-Silvert, V.

    2004-09-01

    The main purpose of this thesis is to get experimental data for the testing and validation of atomic physics codes dealing with non-local-thermodynamical-equilibrium plasmas. The first part is dedicated to the spectroscopic study of xenon and krypton plasmas that have been produced by a nanosecond laser pulse interacting with a gas jet. A Thomson scattering diagnostic has allowed us to measure independently plasma parameters such as electron temperature, electron density and the average ionisation state. We have obtained time integrated spectra in the range between 5 and 10 angstroms. We have identified about one hundred xenon rays between 8.6 and 9.6 angstroms via the use of the Relac code. We have discovered unknown rays for the krypton between 5.2 and 7.5 angstroms. In a second experiment we have extended the wavelength range to the X UV domain. The Averroes/Transpec code has been tested in the ranges from 9 to 15 angstroms and from 10 to 130 angstroms, the first range has been well reproduced while the second range requires a more complex data analysis. The second part is dedicated to the spectroscopic study of aluminium, selenium and samarium plasmas in femtosecond operating rate. We have designed an interferometry diagnostic in the frequency domain that has allowed us to measure the expanding speed of the target's backside. Via the use of an adequate isothermal model this parameter has led us to know the plasma electron temperature. Spectra and emission times of various rays from the aluminium and selenium plasmas have been computed satisfactorily with the Averroes/Transpec code coupled with Film and Multif hydrodynamical codes. (A.C.)

  6. (Non-) homomorphic approaches to denoise intensity SAR images with non-local means and stochastic distances

    Science.gov (United States)

    Penna, Pedro A. A.; Mascarenhas, Nelson D. A.

    2018-02-01

    The development of new methods to denoise images still attract researchers, who seek to combat the noise with the minimal loss of resolution and details, like edges and fine structures. Many algorithms have the goal to remove additive white Gaussian noise (AWGN). However, it is not the only type of noise which interferes in the analysis and interpretation of images. Therefore, it is extremely important to expand the filters capacity to different noise models present in li-terature, for example the multiplicative noise called speckle that is present in synthetic aperture radar (SAR) images. The state-of-the-art algorithms in remote sensing area work with similarity between patches. This paper aims to develop two approaches using the non local means (NLM), developed for AWGN. In our research, we expanded its capacity for intensity SAR ima-ges speckle. The first approach is grounded on the use of stochastic distances based on the G0 distribution without transforming the data to the logarithm domain, like homomorphic transformation. It takes into account the speckle and backscatter to estimate the parameters necessary to compute the stochastic distances on NLM. The second method uses a priori NLM denoising with a homomorphic transformation and applies the inverse Gamma distribution to estimate the parameters that were used into NLM with stochastic distances. The latter method also presents a new alternative to compute the parameters for the G0 distribution. Finally, this work compares and analyzes the synthetic and real results of the proposed methods with some recent filters of the literature.

  7. Robust Non-Local TV-L1 Optical Flow Estimation with Occlusion Detection.

    Science.gov (United States)

    Zhang, Congxuan; Chen, Zhen; Wang, Mingrun; Li, Ming; Jiang, Shaofeng

    2017-06-05

    In this paper, we propose a robust non-local TV-L1 optical flow method with occlusion detection to address the problem of weak robustness of optical flow estimation with motion occlusion. Firstly, a TV-L1 form for flow estimation is defined using a combination of the brightness constancy and gradient constancy assumptions in the data term and by varying the weight under the Charbonnier function in the smoothing term. Secondly, to handle the potential risk of the outlier in the flow field, a general non-local term is added in the TV-L1 optical flow model to engender the typical non-local TV-L1 form. Thirdly, an occlusion detection method based on triangulation is presented to detect the occlusion regions of the sequence. The proposed non-local TV-L1 optical flow model is performed in a linearizing iterative scheme using improved median filtering and a coarse-to-fine computing strategy. The results of the complex experiment indicate that the proposed method can overcome the significant influence of non-rigid motion, motion occlusion, and large displacement motion. Results of experiments comparing the proposed method and existing state-of-the-art methods by respectively using Middlebury and MPI Sintel database test sequences show that the proposed method has higher accuracy and better robustness.

  8. Magnetic field and contact resistance dependence of non-local charge imbalance

    International Nuclear Information System (INIS)

    Kleine, A; Baumgartner, A; Trbovic, J; Schoenenberger, C; Golubev, D S; Zaikin, A D

    2010-01-01

    Crossed Andreev reflection (CAR) in metallic nanostructures, a possible basis for solid-state electron entangler devices, is usually investigated by detecting non-local voltages in multi-terminal superconductor/normal metal devices. This task is difficult because other subgap processes may mask the effects of CAR. One of these processes is the generation of charge imbalance (CI) and the diffusion of non-equilibrium quasi-particles in the superconductor. Here we demonstrate a characteristic dependence of non-local CI on a magnetic field applied parallel to the superconducting wire, which can be understood by a generalization of the standard description of CI to non-local experiments. These results can be used to distinguish CAR and CI and to extract CI relaxation times in superconducting nanostructures. In addition, we investigate the dependence of non-local CI on the resistance of the injector and detector contacts and demonstrate a quantitative agreement with a recent theory using only material and junction characteristics extracted from separate direct measurements.

  9. Non-local effect in Brillouin optical time-domain analyzer based on Raman amplification

    International Nuclear Information System (INIS)

    Jia Xinhong; Rao Yunjiang; Wang Zinan; Zhang Weili; Ran Zengling; Deng Kun; Yang Zixin

    2012-01-01

    Compared with conventional Brillouin optical time-domain analyzer (BOTDA), the BOTDA based on Raman amplification allows longer sensing range, higher signal-to-noise ratio and higher measurement accuracy. However, the non-local effect induced by pump depletion significantly restricts the probe optical power injected to sensing fiber, thereby limiting the further extension for sensing distance. In this paper, the coupled equations including the interaction of probe light, Brillouin and Raman pumps are applied to the study on the non-local characteristics of BOTDA based on Raman amplification. The results show that, the system error induced by non-local effect worsens with increased powers of probe wave and Raman pump. The frequency-division-multiplexing (cascading the fibers with various Brillouin frequency shifts) and time-division-multiplexing (modulating both of the Brillouin pump and probe lights) technologies are efficient approaches to suppress the non-local effect, through shortening the effective interaction range between Brillouin pump and probe lights. (authors)

  10. Quality Assurance of Non-Local Accounting Programs Conducted in Hong Kong

    Science.gov (United States)

    Cheng, Mei-Ai; Leung, Noel W.

    2014-01-01

    This study examines the current government policy and institutional practice on quality assurance of non-local accounting programs conducted in Hong Kong. Both international guidelines, national regulations and institutional frameworks in higher education and transnational higher education, and professional practice in accounting education are…

  11. Improved non-local electron thermal transport model for two-dimensional radiation hydrodynamics simulations

    International Nuclear Information System (INIS)

    Cao, Duc; Moses, Gregory; Delettrez, Jacques

    2015-01-01

    An implicit, non-local thermal conduction algorithm based on the algorithm developed by Schurtz, Nicolai, and Busquet (SNB) [Schurtz et al., Phys. Plasmas 7, 4238 (2000)] for non-local electron transport is presented and has been implemented in the radiation-hydrodynamics code DRACO. To study the model's effect on DRACO's predictive capability, simulations of shot 60 303 from OMEGA are completed using the iSNB model, and the computed shock speed vs. time is compared to experiment. Temperature outputs from the iSNB model are compared with the non-local transport model of Goncharov et al. [Phys. Plasmas 13, 012702 (2006)]. Effects on adiabat are also examined in a polar drive surrogate simulation. Results show that the iSNB model is not only capable of flux-limitation but also preheat prediction while remaining numerically robust and sacrificing little computational speed. Additionally, the results provide strong incentive to further modify key parameters within the SNB theory, namely, the newly introduced non-local mean free path. This research was supported by the Laboratory for Laser Energetics of the University of Rochester

  12. Improved non-local electron thermal transport model for two-dimensional radiation hydrodynamics simulations

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Duc; Moses, Gregory [University of Wisconsin—Madison, 1500 Engineering Drive, Madison, Wisconsin 53706 (United States); Delettrez, Jacques [Laboratory for Laser Energetics of the University of Rochester, 250 East River Road, Rochester, New York 14623 (United States)

    2015-08-15

    An implicit, non-local thermal conduction algorithm based on the algorithm developed by Schurtz, Nicolai, and Busquet (SNB) [Schurtz et al., Phys. Plasmas 7, 4238 (2000)] for non-local electron transport is presented and has been implemented in the radiation-hydrodynamics code DRACO. To study the model's effect on DRACO's predictive capability, simulations of shot 60 303 from OMEGA are completed using the iSNB model, and the computed shock speed vs. time is compared to experiment. Temperature outputs from the iSNB model are compared with the non-local transport model of Goncharov et al. [Phys. Plasmas 13, 012702 (2006)]. Effects on adiabat are also examined in a polar drive surrogate simulation. Results show that the iSNB model is not only capable of flux-limitation but also preheat prediction while remaining numerically robust and sacrificing little computational speed. Additionally, the results provide strong incentive to further modify key parameters within the SNB theory, namely, the newly introduced non-local mean free path. This research was supported by the Laboratory for Laser Energetics of the University of Rochester.

  13. Local and non-local Schroedinger cat states in cavity QED

    International Nuclear Information System (INIS)

    Haroche, S.

    2005-01-01

    Full text: I will review recent experiments performed on mesoscopic state superpositions of field states in cavity QED. Proposals to extend these studies to Schroedinger cat states delocalized in two cavities will be discussed. New versions of Bell's inequality tests will probe the non-local behavior of these cats and study their sensitivity to decoherence. (author)

  14. A NEW COMBINED LOCAL AND NON-LOCAL PBL MODEL FOR METEOROLOGY AND AIR QUALITY MODELING

    Science.gov (United States)

    A new version of the Asymmetric Convective Model (ACM) has been developed to describe sub-grid vertical turbulent transport in both meteorology models and air quality models. The new version (ACM2) combines the non-local convective mixing of the original ACM with local eddy diff...

  15. Nehari manifold for non-local elliptic operator with concave–convex ...

    Indian Academy of Sciences (India)

    Introduction. We consider the following p-fractional Laplace equation ... ators of elliptic type due to concrete real world applications in finance, thin obstacle .... Due to the non-localness of the operator LK, we define the linear space as follows:.

  16. A new approach to non-local boundary value problems for ordinary differential systems

    Czech Academy of Sciences Publication Activity Database

    Rontó, András; Rontó, M.; Shchobak, N.

    2015-01-01

    Roč. 250, č. 1 (2015), s. 689-700 ISSN 0096-3003 Institutional support: RVO:67985840 Keywords : non-local problem * parametrisation * successive approximations Subject RIV: BA - General Mathematics Impact factor: 1.345, year: 2015 http://www.sciencedirect.com/science/article/pii/S0096300314015434

  17. IMPLICATIONS OF NON-LOCALITY OF TRANSPORT IN GEOMORPHIC TRANSPORT LAWS: HILLSLOPES AND LANDSCAPE EVOLUTION MODELING

    Science.gov (United States)

    Foufoula-Georgiou, E.; Ganti, V. K.; Dietrich, W. E.

    2009-12-01

    Sediment transport on hillslopes can be thought of as a hopping process, where the sediment moves in a series of jumps. A wide range of processes shape the hillslopes which can move sediment to a large distance in the downslope direction, thus, resulting in a broad-tail in the probability density function (PDF) of hopping lengths. Here, we argue that such a broad-tailed distribution calls for a non-local computation of sediment flux, where the sediment flux is not only a function of local topographic quantities but is an integral flux which takes into account the upslope topographic “memory” of the point of interest. We encapsulate this non-local behavior into a simple fractional diffusive model that involves fractional (non-integer) derivatives. We present theoretical predictions from this nonlocal model and demonstrate a nonlinear dependence of sediment flux on local gradient, consistent with observations. Further, we demonstrate that the non-local model naturally eliminates the scale-dependence exhibited by any local (linear or nonlinear) sediment transport model. An extension to a 2-D framework, where the fractional derivative can be cast into a mixture of directional derivatives, is discussed together with the implications of introducing non-locality into existing landscape evolution models.

  18. Improved non-local electron thermal transport model for two-dimensional radiation hydrodynamics simulations

    Science.gov (United States)

    Cao, Duc; Moses, Gregory; Delettrez, Jacques

    2015-08-01

    An implicit, non-local thermal conduction algorithm based on the algorithm developed by Schurtz, Nicolai, and Busquet (SNB) [Schurtz et al., Phys. Plasmas 7, 4238 (2000)] for non-local electron transport is presented and has been implemented in the radiation-hydrodynamics code DRACO. To study the model's effect on DRACO's predictive capability, simulations of shot 60 303 from OMEGA are completed using the iSNB model, and the computed shock speed vs. time is compared to experiment. Temperature outputs from the iSNB model are compared with the non-local transport model of Goncharov et al. [Phys. Plasmas 13, 012702 (2006)]. Effects on adiabat are also examined in a polar drive surrogate simulation. Results show that the iSNB model is not only capable of flux-limitation but also preheat prediction while remaining numerically robust and sacrificing little computational speed. Additionally, the results provide strong incentive to further modify key parameters within the SNB theory, namely, the newly introduced non-local mean free path. This research was supported by the Laboratory for Laser Energetics of the University of Rochester.

  19. The sheaf-theoretic structure of non-locality and contextuality

    International Nuclear Information System (INIS)

    Abramsky, Samson; Brandenburger, Adam

    2011-01-01

    We use the mathematical language of sheaf theory to give a unified treatment of non-locality and contextuality, in a setting that generalizes the familiar probability tables used in non-locality theory to arbitrary measurement covers; this includes Kochen-Specker configurations and more. We show that contextuality, and non-locality as a special case, correspond exactly to obstructions to the existence of global sections. We describe a linear algebraic approach to computing these obstructions, which allows a systematic treatment of arguments for non-locality and contextuality. We distinguish a proper hierarchy of strengths of no-go theorems, and show that three leading examples—due to Bell, Hardy and Greenberger, Horne and Zeilinger, respectively—occupy successively higher levels of this hierarchy. A general correspondence is shown between the existence of local hidden-variable realizations using negative probabilities, and no-signalling; this is based on a result showing that the linear subspaces generated by the non-contextual and no-signalling models, over an arbitrary measurement cover, coincide. Maximal non-locality is generalized to maximal contextuality, and characterized in purely qualitative terms, as the non-existence of global sections in the support. A general setting is developed for the Kochen-Specker-type results, as generic, model-independent proofs of maximal contextuality, and a new combinatorial condition is given, which generalizes the ‘parity proofs’ commonly found in the literature. We also show how our abstract setting can be represented in quantum mechanics. This leads to a strengthening of the usual no-signalling theorem, which shows that quantum mechanics obeys no-signalling for arbitrary families of commuting observables, not just those represented on different factors of a tensor product. (paper)

  20. Large-Scale Network Analysis of Whole-Brain Resting-State Functional Connectivity in Spinal Cord Injury: A Comparative Study.

    Science.gov (United States)

    Kaushal, Mayank; Oni-Orisan, Akinwunmi; Chen, Gang; Li, Wenjun; Leschke, Jack; Ward, Doug; Kalinosky, Benjamin; Budde, Matthew; Schmit, Brian; Li, Shi-Jiang; Muqeet, Vaishnavi; Kurpad, Shekar

    2017-09-01

    Network analysis based on graph theory depicts the brain as a complex network that allows inspection of overall brain connectivity pattern and calculation of quantifiable network metrics. To date, large-scale network analysis has not been applied to resting-state functional networks in complete spinal cord injury (SCI) patients. To characterize modular reorganization of whole brain into constituent nodes and compare network metrics between SCI and control subjects, fifteen subjects with chronic complete cervical SCI and 15 neurologically intact controls were scanned. The data were preprocessed followed by parcellation of the brain into 116 regions of interest (ROI). Correlation analysis was performed between every ROI pair to construct connectivity matrices and ROIs were categorized into distinct modules. Subsequently, local efficiency (LE) and global efficiency (GE) network metrics were calculated at incremental cost thresholds. The application of a modularity algorithm organized the whole-brain resting-state functional network of the SCI and the control subjects into nine and seven modules, respectively. The individual modules differed across groups in terms of the number and the composition of constituent nodes. LE demonstrated statistically significant decrease at multiple cost levels in SCI subjects. GE did not differ significantly between the two groups. The demonstration of modular architecture in both groups highlights the applicability of large-scale network analysis in studying complex brain networks. Comparing modules across groups revealed differences in number and membership of constituent nodes, indicating modular reorganization due to neural plasticity.

  1. Perspectives on the Direction of the Suncheon Bay National Garden from Local Residents and Non-Local Visitors

    Directory of Open Access Journals (Sweden)

    Moohan Kim

    2017-10-01

    Full Text Available As Korea’s first national garden, the Suncheon Bay National Garden is a major tourist attraction and a space of enjoyment for visitors. However, in 2016 its sudden establishment necessitates many discussions and measures, and requires that it seek direction based on current perceptions for its continued use in the future. This study begins a search for that direction by examining perspectives of local residents and non-local visitors on the relationships between visitors’ purposes, spatial needs, and required features. The research methodology included a survey administered to Suncheon residents and tourists on these factors. Results were analyzed by multiple correlation analysis and networking between the variables, and differences between Suncheon residents and non-local visitors were deduced; relationships among the factors were also verified. Both locals and visitors saw a need to emphasize garden experiences and education. The study also presents items that differ by respondent group. This study provides information that can be referred to when implementing management and plans for other national gardens.

  2. Bending analysis of agglomerated carbon nanotube-reinforced beam resting on two parameters modified Vlasov model foundation

    Science.gov (United States)

    Ghorbanpour Arani, A.; Zamani, M. H.

    2018-06-01

    The present work deals with bending behavior of nanocomposite beam resting on two parameters modified Vlasov model foundation (MVMF), with consideration of agglomeration and distribution of carbon nanotubes (CNTs) in beam matrix. Equivalent fiber based on Eshelby-Mori-Tanaka approach is employed to determine influence of CNTs aggregation on elastic properties of CNT-reinforced beam. The governing equations are deduced using the principle of minimum potential energy under assumption of the Euler-Bernoulli beam theory. The MVMF required the estimation of γ parameter; to this purpose, unique iterative technique based on variational principles is utilized to compute value of the γ and subsequently fourth-order differential equation is solved analytically. Eventually, the transverse displacements and bending stresses are obtained and compared for different agglomeration parameters, various boundary conditions simultaneously and variant elastic foundation without requirement to instate values for foundation parameters.

  3. Geometrically nonlinear dynamic and static analysis of shallow spherical shell resting on two-parameters elastic foundations

    International Nuclear Information System (INIS)

    Civalek, Ö.

    2014-01-01

    In the present study nonlinear static and dynamic responses of shallow spherical shells resting on Winkler–Pasternak elastic foundations are carried out. The formulation of the shells is based on the Donnell theory. The nonlinear governing equations of motion of shallow shells are discretized in space and time domains using the discrete singular convolution and the differential quadrature methods, respectively. The validity of the present method is demonstrated by comparing the present results with those available in the open literature. The effects of the Winkler and Pasternak foundation parameters on nonlinear static and dynamic response of shells are investigated. Some results are also presented for circular plate as special case. Damping effect on nonlinear dynamic response of shells is studied. It is important to state that the increase in damping parameter causes decrease in the dynamic response of the shells. It is shown that the shear parameter of the foundation has a significant influence on the dynamic and static response of the shells. Also, the response of the shell is decreased with the increasing value of the shear parameter of the foundation. Parametric studies considering different geometric variables have also been investigated. -- Highlights: • Nonlinear responses of shallow spherical shells are presented. • The effects of foundation parameters are investigated. • Damping effect on nonlinear dynamic response of shells is also studied

  4. Inverse dualization and non-local dualities between Einstein gravity and supergravities

    International Nuclear Information System (INIS)

    Chen Chiangmei; Gal'tsov, Dmitri V; Sharakin, Sergei A

    2002-01-01

    We investigate non-local dualities between suitably compactified higher dimensional Einstein gravity and supergravities which can be revealed if one reinterprets the dualized Kaluza-Klein 2-forms in D>4 as antisymmetric forms belonging to supergravities. We find several examples of such a correspondence including one between the six-dimensional Einstein gravity and the four-dimensional Einstein-Maxwell-dilaton-axion theory (truncated N=4 supergravity), and others between the compactified eleven- and ten-dimensional supergravities and the eight- or ten-dimensional pure gravity. The Killing spinor equation of the D=11 supergravity is shown to be equivalent to the geometric Killing spinor equation in the dual gravity. We give several examples of using new dualities for solution generation and demonstrate how p-branes can be interpreted as non-local duals of pure gravity solutions. New supersymmetric solutions are presented including M2 subset of 5-brane with two rotation parameters

  5. The non-local Fisher–KPP equation: travelling waves and steady states

    International Nuclear Information System (INIS)

    Berestycki, Henri; Nadin, Grégoire; Perthame, Benoit; Ryzhik, Lenya

    2009-01-01

    We consider the Fisher–KPP equation with a non-local saturation effect defined through an interaction kernel φ(x) and investigate the possible differences with the standard Fisher–KPP equation. Our first concern is the existence of steady states. We prove that if the Fourier transform φ-circumflex(ξ) is positive or if the length σ of the non-local interaction is short enough, then the only steady states are u ≡ 0 and u ≡ 1. Next, we study existence of the travelling waves. We prove that this equation admits travelling wave solutions that connect u = 0 to an unknown positive steady state u ∞ (x), for all speeds c ≥ c * . The travelling wave connects to the standard state u ∞ (x) ≡ 1 under the aforementioned conditions: φ-circumflex(ξ) > 0 or σ is sufficiently small. However, the wave is not monotonic for σ large

  6. Definition of current density in the presence of a non-local potential.

    Science.gov (United States)

    Li, Changsheng; Wan, Langhui; Wei, Yadong; Wang, Jian

    2008-04-16

    In the presence of a non-local potential arising from electron-electron interaction, the conventional definition of current density J(c) = (e/2m)([(p-eA)ψ](*)ψ-ψ(*)[(p-eA)ψ]) cannot satisfy the condition of current conservation, i.e., [Formula: see text] in the steady state. In order to solve this problem, we give a new definition of current density including the contribution due to the non-local potential. We show that the current calculated based on the new definition of current density conserves the current and is the same as that obtained from the Landauer-Büttiker formula. Examples are given to demonstrate our results.

  7. The non-local universe the new physics and matters of the mind

    CERN Document Server

    Nadeau, Robert

    2002-01-01

    Classical physics states that physical reality is local, or that a measurement at one point in space cannot cannot influence what occurs at another beyond a fairly short distance. Until recently this seemed like an immutable truth in nature. However, in 1997 experiments were conducted in which light particles (photons) originated under certain conditions and traveled in opposite directions to detectors located about seven miles apart. The amazing results indicated that the photons "interacted" or "communicated" with one another instantly or "in no time," leading to the revelation that physical reality is non-local--a discovery that Robert Nadeau and Menas Kafatos view as "the most momentous in the history of science.". In pursuing this groundbreaking argument, the authors provide a fascinating history of developments that led to the discovery of non-locality and the sometimes heated debate between the great scientists responsible for these discoveries. What this new knowledge reveals, the authors conclude, is...

  8. Surface green function matching for a three-dimensional non-local continuum

    International Nuclear Information System (INIS)

    Idiodi, J.O.A.

    1985-07-01

    With a view toward helping to bridge the gap, from the continuum side, between discrete and continuum models of crystalline, elastic solids, explicit results are presented for non-local stress tensors that describe exactly some lattice dynamical models that have been widely used in the literature for cubic lattices. The Surface Green Function Matching (SGFM) method, which has been used successfully for a variety of surface problems, is then extended, within a continuum approach, to a non-local continuum that models a three-dimensional discrete lattice. The practical use of the method is demonstrated by performing a fairly complete analytical study of the vibrational surface modes of the SCC semi-infinite medium. Some results are presented for the [100] direction of the (001) surface of the SCC lattice. (author)

  9. Longitudinally Vibrating Elastic Rods with Locally and Non-Locally Reacting Viscous Dampers

    Directory of Open Access Journals (Sweden)

    Şefaatdin Yüksel

    2005-01-01

    Full Text Available Eigencharacteristics of a longitudinally vibrating elastic rod with locally and non-locally reacting damping are analyzed. The rod is considered as a continuous system and complex eigenfrequencies are determined as solution of a characteristic equation. The variation of the damping ratios with respect to damper locations and damping coefficients for the first four eigenfrequencies are obtained. It is shown that at any mode of locally or non-locally damped elastic rod, the variation of damping ratio with damper location is linearly proportional to absolute value of the mode shape of undamped system. It is seen that the increasing damping coefficient does not always increase the damping ratio and there are optimal values for the damping ratio. Optimal values for external damping coefficients of viscous dampers and locations of the dampers are presented.

  10. Stable bounce and inflation in non-local higher derivative cosmology

    International Nuclear Information System (INIS)

    Biswas, Tirthabir; Koshelev, Alexey S.; Mazumdar, Anupam; Vernov, Sergey Yu.

    2012-01-01

    One of the greatest problems of primordial inflation is that the inflationary space-time is past-incomplete. This is mainly because Einstein's GR suffers from a space-like Big Bang singularity. It has recently been shown that ghost-free, non-local higher-derivative ultra-violet modifications of Einstein's gravity may be able to resolve the cosmological Big Bang singularity via a non-singular bounce. Within the framework of such non-local cosmological models, we are going to study both sub- and super-Hubble perturbations around an inflationary trajectory which is preceded by the Big Bounce in the past, and demonstrate that the inflationary trajectory has an ultra-violet completion and that perturbations do not suffer from any pathologies

  11. Definition of current density in the presence of a non-local potential

    International Nuclear Information System (INIS)

    Li Changsheng; Wan Langhui; Wei Yadong; Wang Jian

    2008-01-01

    In the presence of a non-local potential arising from electron-electron interaction, the conventional definition of current density J c = (e/2m)([(p-eA)ψ]*ψ-ψ*[(p-eA)ψ]) cannot satisfy the condition of current conservation, i.e., ∇ . J c ≠ 0 in the steady state. In order to solve this problem, we give a new definition of current density including the contribution due to the non-local potential. We show that the current calculated based on the new definition of current density conserves the current and is the same as that obtained from the Landauer-Buettiker formula. Examples are given to demonstrate our results

  12. Convergence of solutions of a non-local phase-field system

    Czech Academy of Sciences Publication Activity Database

    Londen, S.-O.; Petzeltová, Hana

    2011-01-01

    Roč. 4, č. 3 (2011), s. 653-670 ISSN 1937-1632 R&D Projects: GA AV ČR(CZ) IAA100190606 Institutional research plan: CEZ:AV0Z10190503 Keywords : non-local phase-field systems * separation property * convergence to equilibria Subject RIV: BA - General Mathematics http://www.aimsciences.org/journals/displayArticles.jsp?paperID=5698

  13. Construction of local and non-local conservation laws for non-linear field equations

    International Nuclear Information System (INIS)

    Vladimirov, V.S.; Volovich, I.V.

    1984-08-01

    A method of constructing conserved currents for non-linear field equations is presented. More explicitly for non-linear equations, which can be derived from compatibility conditions of some linear system with a parameter, a procedure of obtaining explicit expressions for local and non-local currents is developed. Some examples such as the classical Heisenberg spin chain and supersymmetric Yang-Mills theory are considered. (author)

  14. Local vs. Non-local core potentials in electron scattering from sodium atoms

    International Nuclear Information System (INIS)

    Bartschat, K.; Bray, I.

    1996-02-01

    We have tested the use of a local potential instead of the non-local Hartree-Fock potential to represent exchange effects between the valence or the projectile electron and the core in electron scattering from sodium atoms For some of the most detailed observables in this collision system/ the results of the two approaches are nearly identical, even though the effect of the exchange part is shown to be particularly large. (authors). 16 refs., 4 figs

  15. The algebra of non-local charges in non-linear sigma models

    International Nuclear Information System (INIS)

    Abdalla, E.; Abdalla, M.C.B.; Brunelli, J.C.; Zadra, A.

    1994-01-01

    It is derived the complete Dirac algebra satisfied by non-local charges conserved in non-linear sigma models. Some examples of calculation are given for the O(N) symmetry group. The resulting algebra corresponds to a saturated cubic deformation (with only maximum order terms) of the Kac-Moody algebra. The results are generalized for when a Wess-Zumino term be present. In that case the algebra contains a minor order correction (sub-saturation). (author). 1 ref

  16. Local versus non-local core potentials in electron scattering from sodium atoms

    International Nuclear Information System (INIS)

    Bartschat, K.; Bray, I.

    1996-01-01

    We have tested the use of a local potential instead of the non-local Hartree-Fock potential to represent exchange effects between the valence or the projectile electron and the core in electron scattering from sodium atoms. For some of the most detailed observables in this collision system, the results of the two approaches are nearly identical, even though the effect of the exchange part is shown to be particularly large. (Author)

  17. An anthology of non-local QFT and QFT on noncommutative spacetime

    International Nuclear Information System (INIS)

    Schroer, Bert; E-mail schroer@cbpf.br

    2004-05-01

    Ever since the appearance of renormalization theory there have been several differently motivated attempts at non-localized (in the sense of not generated by point-like fields) relativistic particle theories, the most recent one being at QFT on non-commutative Minkowski spacetime. The often conceptually uncritical and historically forgetful contemporary approach to these problems calls for a critical review of contemporary ideas in the light of previous results on this subject. (author)

  18. An anthology of non-local QFT and QFT on non-commutative spacetime

    Science.gov (United States)

    Schroer, Bert

    2005-09-01

    Ever since the appearance of renormalization theory, there have been several differently motivated attempts at non-localized (in the sense of not generated by pointlike fields) relativistic particle theories, the most recent one being at QFT on non-commutative Minkowski spacetime. The often conceptually uncritical and historically forgetful contemporary approach to these problems calls for a critical review in the light of previous results on this subject.

  19. An anthology of non-local QFT and QFT on non-commutative spacetime

    International Nuclear Information System (INIS)

    Schroer, Bert

    2005-01-01

    Ever since the appearance of renormalization theory, there have been several differently motivated attempts at non-localized (in the sense of not generated by pointlike fields) relativistic particle theories, the most recent one being at QFT on non-commutative Minkowski spacetime. The often conceptually uncritical and historically forgetful contemporary approach to these problems calls for a critical review in the light of previous results on this subject

  20. Non-locality and memory effects in grain dynamics on a 2D dusty plasma quasi-crystal

    International Nuclear Information System (INIS)

    Ratynskaia, S.; Rypdal, K.; Milovanov, A.; Rasmussen, J. J.; Knapek, C.; Morfill, G.

    2005-01-01

    By tuning RF-power and neutral gas pressure as control parameters in a dust plasma crystal experiment it is possible to obtain a state exhibiting rather high mobility of the dust grains through development of defects, yet maintaining the global hexagonal structure. The state exhibits higher mobility and smaller vertical structures along the rim and larger and more slowly moving and rotating crystalline domains in the core. It is different from the critical transition between the crystalline and liquid state. Trajectories of all particles in a cluster consisting of about 700 dust grains are tracked through 30.000 frames (time-steps). During this time the length of a grain trajectory is typically considerably greater than the linear size of the cluster. Variogram and rescaled range (R/S) analysis of time series of particle positions reveal super-diffusive behavior which, from a stochastic process viewpoint, often is ascribed to either long memory effects or to the presence of non-locality manifested as Levy flights giving rise to heavy algebraic tails in the position increment probability distribution function (PDF). The experimental PDF is non-gaussian, but the tails are not algebraic. The core of the PDF, however, has the shape of a truncated Levy distribution, which is shown to be stretched exponential of width that expands in time in a super-diffusive manner. Thus, super-diffusion could in principle occur without long-range time dependence in the increment time series and without algebraic tails in the PDF. Analysis of the core PDF and PDFs on different level of coarse gaining of the time series, combined with variogram and R/S analysis techniques, are employed to disentangle memory and non-locality effects. The results are discussed and interpreted in the framework of a fractional kinetics approach. (Author)

  1. The right inferior frontal gyrus processes nested non-local dependencies in music.

    Science.gov (United States)

    Cheung, Vincent K M; Meyer, Lars; Friederici, Angela D; Koelsch, Stefan

    2018-02-28

    Complex auditory sequences known as music have often been described as hierarchically structured. This permits the existence of non-local dependencies, which relate elements of a sequence beyond their temporal sequential order. Previous studies in music have reported differential activity in the inferior frontal gyrus (IFG) when comparing regular and irregular chord-transitions based on theories in Western tonal harmony. However, it is unclear if the observed activity reflects the interpretation of hierarchical structure as the effects are confounded by local irregularity. Using functional magnetic resonance imaging (fMRI), we found that violations to non-local dependencies in nested sequences of three-tone musical motifs in musicians elicited increased activity in the right IFG. This is in contrast to similar studies in language which typically report the left IFG in processing grammatical syntax. Effects of increasing auditory working demands are moreover reflected by distributed activity in frontal and parietal regions. Our study therefore demonstrates the role of the right IFG in processing non-local dependencies in music, and suggests that hierarchical processing in different cognitive domains relies on similar mechanisms that are subserved by domain-selective neuronal subpopulations.

  2. Post-Newtonian parameter γ in generalized non-local gravity

    Science.gov (United States)

    Zhang, Xue; Wu, YaBo; Yang, WeiQiang; Zhang, ChengYuan; Chen, BoHai; Zhang, Nan

    2017-10-01

    We investigate the post-Newtonian parameter γ and derive its formalism in generalized non-local (GNL) gravity, which is the modified theory of general relativity (GR) obtained by adding a term m 2 n-2 R☐-n R to the Einstein-Hilbert action. Concretely, based on parametrizing the generalized non-local action in which gravity is described by a series of dynamical scalar fields ϕ i in addition to the metric tensor g μν, the post-Newtonian limit is computed, and the effective gravitational constant as well as the post-Newtonian parameters are directly obtained from the generalized non-local gravity. Moreover, by discussing the values of the parametrized post-Newtonian parameters γ, we can compare our expressions and results with those in Hohmann and Järv et al. (2016), as well as current observational constraints on the values of γ in Will (2006). Hence, we draw restrictions on the nonminimal coupling terms F̅ around their background values.

  3. A non-local hidden-variable model that violates Leggett-type inequalities

    Energy Technology Data Exchange (ETDEWEB)

    Zela, F de [Departamento de Ciencias, Seccion Fisica, Pontificia Universidad Catolica del Peru, Apartado 1761, Lima (Peru)

    2008-12-19

    Recent experiments of Groeblacher et al proved the violation of a Leggett-type inequality that was claimed to be valid for a broad class of non-local hidden-variable theories. The impossibility of constructing a non-local and realistic theory, unless it entails highly counterintuitive features, seems thus to have been experimentally proved. This would bring us close to a definite refutation of realism. Indeed, realism was proved to be also incompatible with locality, according to a series of experiments testing Bell inequalities. The present paper addresses the said experiments of Groeblacher et al and presents an explicit, contextual and realistic, model that reproduces the predictions of quantum mechanics. It thus violates the Leggett-type inequality that was established with the aim of ruling out a supposedly broad class of non-local models. We can thus conclude that plausible contextual, realistic, models are still tenable. This restates the possibility of a future completion of quantum mechanics by a realistic and contextual theory which is not in a class containing only highly counterintuitive models. The class that was ruled out by the experiments of Groeblacher et al is thus proved to be a limited one, arbitrarily separating models that physically belong in the same class.

  4. Non-local electron transport validation using 2D DRACO simulations

    Science.gov (United States)

    Cao, Duc; Chenhall, Jeff; Moll, Eli; Prochaska, Alex; Moses, Gregory; Delettrez, Jacques; Collins, Tim

    2012-10-01

    Comparison of 2D DRACO simulations, using a modified versionfootnotetextprivate communications with M. Marinak and G. Zimmerman, LLNL. of the Schurtz, Nicolai and Busquet (SNB) algorithmfootnotetextSchurtz, Nicolai and Busquet, ``A nonlocal electron conduction model for multidimensional radiation hydrodynamics codes,'' Phys. Plasmas 7, 4238(2000). for non-local electron transport, with direct drive shock timing experimentsfootnotetextT. Boehly, et. al., ``Multiple spherically converging shock waves in liquid deuterium,'' Phys. Plasmas 18, 092706(2011). and with the Goncharov non-local modelfootnotetextV. Goncharov, et. al., ``Early stage of implosion in inertial confinement fusion: Shock timing and perturbation evolution,'' Phys. Plasmas 13, 012702(2006). in 1D LILAC will be presented. Addition of an improved SNB non-local electron transport algorithm in DRACO allows direct drive simulations with no need for an electron conduction flux limiter. Validation with shock timing experiments that mimic the laser pulse profile of direct drive ignition targets gives a higher confidence level in the predictive capability of the DRACO code. This research was supported by the University of Rochester Laboratory for Laser Energetics.

  5. Non-localized deformation in Cu−Zr multi-layer amorphous films under tension

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, C. [International Center for New-Structured Materials (ICNSM), Laboratory of New-Structured Materials, State Key Laboratory of Silicon Materials, and School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027 (China); Zhang, H. [International Center for New-Structured Materials (ICNSM), Laboratory of New-Structured Materials, State Key Laboratory of Silicon Materials, and School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027 (China); Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9 (Canada); Cao, Q.P.; Wang, X.D. [International Center for New-Structured Materials (ICNSM), Laboratory of New-Structured Materials, State Key Laboratory of Silicon Materials, and School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027 (China); Zhang, D.X. [State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027 (China); Hu, J.W. [Hangzhou Workers Amateur University, Hangzhou 310027 (China); Liaw, P.K. [Department of Materials Science and Engineering, The University of Tennessee, Knoxville, TN 37996 (United States); Jiang, J.Z., E-mail: jiangjz@zju.edu.cn [International Center for New-Structured Materials (ICNSM), Laboratory of New-Structured Materials, State Key Laboratory of Silicon Materials, and School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027 (China)

    2016-09-05

    In metallic glasses (MGs), plastic deformation at room temperature is dominated by highly localized shear bands. Here we report the non-localized deformation under tension in Cu−Zr multi-layer MGs with a pure amorphous structure using large-scale atomistic simulations. It is demonstrated that amorphous samples with high layer numbers, composed of Cu{sub 64}Zr{sub 36} and Cu{sub 40}Zr{sub 60}, or Cu{sub 64}Zr{sub 36} and Cu{sub 50}Zr{sub 50}, present obviously non-localized deformation behavior. We reveal that the deformation behavior of the multi-layer-structured MG films is related but not determined by the deformation behavior of the composed individual layers. The criterion for the deformation mode change for MGs with a pure amorphous structure, in generally, was suggested, i.e., the competition between the elastic-energy density stored and the energy density needed for forming one mature shear band in MGs. Our results provide a promising strategy for designing tensile ductile MGs with a pure amorphous structure at room temperature. - Highlights: • Tensile deformation behaviors in multi-layer MG films. • Films with high layer numbers confirmed with a non-localized deformation behavior. • The deformation mode is reasonably controlled by whether U{sub p} larger than U{sub SB.}.

  6. Non-local electrical spin injection and detection in germanium at room temperature

    Science.gov (United States)

    Rortais, F.; Vergnaud, C.; Marty, A.; Vila, L.; Attané, J.-P.; Widiez, J.; Zucchetti, C.; Bottegoni, F.; Jaffrès, H.; George, J.-M.; Jamet, M.

    2017-10-01

    Non-local carrier injection/detection schemes lie at the very foundation of information manipulation in integrated systems. This paradigm consists in controlling with an external signal the channel where charge carriers flow between a "source" and a well separated "drain." The next generation electronics may operate on the spin of carriers in addition to their charge and germanium appears as the best hosting material to develop such a platform for its compatibility with mainstream silicon technology and the predicted long electron spin lifetime at room temperature. In this letter, we demonstrate injection of pure spin currents (i.e., with no associated transport of electric charges) in germanium, combined with non-local spin detection at 10 K and room temperature. For this purpose, we used a lateral spin valve with epitaxially grown magnetic tunnel junctions as spin injector and spin detector. The non-local magnetoresistance signal is clearly visible and reaches ≈15 mΩ at room temperature. The electron spin lifetime and diffusion length are 500 ps and 1 μm, respectively, the spin injection efficiency being as high as 27%. This result paves the way for the realization of full germanium spintronic devices at room temperature.

  7. Quantum Noether identities for non-local transformations in higher-order derivatives theories

    International Nuclear Information System (INIS)

    Li, Z.P.; Long, Z.W.

    2003-01-01

    Based on the phase-space generating functional of the Green function for a system with a regular/singular higher-order Lagrangian, the quantum canonical Noether identities (NIs) under a local and non-local transformation in phase space have been deduced, respectively. For a singular higher-order Lagrangian, one must use an effective canonical action I eff P in quantum canonical NIs instead of the classical I P in classical canonical NIs. The quantum NIs under a local and non-local transformation in configuration space for a gauge-invariant system with a higher-order Lagrangian have also been derived. The above results hold true whether or not the Jacobian of the transformation is equal to unity or not. It has been pointed out that in certain cases the quantum NIs may be converted to conservation laws at the quantum level. This algorithm to derive the quantum conservation laws is significantly different from the quantum first Noether theorem. The applications of our formulation to the Yang-Mills fields and non-Abelian Chern-Simons (CS) theories with higher-order derivatives are given, and the conserved quantities at the quantum level for local and non-local transformations are found, respectively. (orig.)

  8. 'Non-local' response of RTP ohmic plasmas to peripheral perturbations

    International Nuclear Information System (INIS)

    Galli, P.; Gorini, G.; Mantica, P.; Hogeweij, G.M.D.; Kloe, J. de; Lopes Cardozo, N.J.

    1999-01-01

    A 'non-local' response of the plasma core triggered by peripheral plasma perturbations other than laser ablation is found in the RTP tokamak. Oblique pellet injection (OPI) has been used to induce fast cooling of the peripheral plasma. In response, an inward cold pulse (T e drop) and a slightly delayed core T e rise are observed. A somewhat similar 'non-local' response is observed when the peripheral plasma is heated by modulated electron cyclotron heating or by fast current ramps, i.e. the core temperature drops in response to the peripheral heating. The plasma conditions for the occurrence of the 'non-local' response have been investigated. The core T e rise following OPI is associated with the formation of a large temperature gradient in the region 1 e rise is largest at low electron density and for large pellet deposition radii. Above a critical density the T e rise disappears and only the (weaker) drop in core T e is observed. Time dependent transport simulations show that the propagation of the inward cold pulse is consistent with local transport, while the core T e rise is a slower phenomenon requiring a large transient drop of χ e in the region 1 < q < 2. (author)

  9. A non-local hidden-variable model that violates Leggett-type inequalities

    International Nuclear Information System (INIS)

    Zela, F de

    2008-01-01

    Recent experiments of Groeblacher et al proved the violation of a Leggett-type inequality that was claimed to be valid for a broad class of non-local hidden-variable theories. The impossibility of constructing a non-local and realistic theory, unless it entails highly counterintuitive features, seems thus to have been experimentally proved. This would bring us close to a definite refutation of realism. Indeed, realism was proved to be also incompatible with locality, according to a series of experiments testing Bell inequalities. The present paper addresses the said experiments of Groeblacher et al and presents an explicit, contextual and realistic, model that reproduces the predictions of quantum mechanics. It thus violates the Leggett-type inequality that was established with the aim of ruling out a supposedly broad class of non-local models. We can thus conclude that plausible contextual, realistic, models are still tenable. This restates the possibility of a future completion of quantum mechanics by a realistic and contextual theory which is not in a class containing only highly counterintuitive models. The class that was ruled out by the experiments of Groeblacher et al is thus proved to be a limited one, arbitrarily separating models that physically belong in the same class

  10. Non-localization and localization ROC analyses using clinically based scoring

    Science.gov (United States)

    Paquerault, Sophie; Samuelson, Frank W.; Myers, Kyle J.; Smith, Robert C.

    2009-02-01

    . The results on the variance analysis differed from those observed in the other study setting. This investigation furthers our understanding of the relationships between non-localization-specific and localization-specific ROC assessment methodologies and their relevance to clinical practice.

  11. Robust non-local effects of ocean heat uptake on radiative feedback and subtropical cloud cover

    Science.gov (United States)

    Rose, B. E. J.

    2016-02-01

    moisture. Our results suggest that cloud feedback under transient climate change is partly modulated by ocean heat uptake through robust but non-local atmospheric processes, and has implications on a timescales ranging from inter-annual to multi-centennial.

  12. Comparing consistency of R2* and T2*-weighted BOLD analysis of resting state fetal fMRI

    Science.gov (United States)

    Seshamani, Sharmishtaa; Blazejewska, Anna I.; Gatenby, Christopher; Mckown, Susan; Caucutt, Jason; Dighe, Manjiri; Studholme, Colin

    2015-03-01

    Understanding when and how resting state brain functional activity begins in the human brain is an increasing area of interest in both basic neuroscience and in the clinical evaluation of the brain during pregnancy and after premature birth. Although fMRI studies have been carried out on pregnant women since the 1990's, reliable mapping of brain function in utero is an extremely challenging problem due to the unconstrained fetal head motion. Recent studies have employed scrubbing to exclude parts of the time series and whole subjects from studies in order to control the confounds of motion. Fundamentally, even after correction of the location of signals due to motion, signal intensity variations are a fundamental limitation, due to coil sensitivity and spin history effects. An alternative technique is to use a more parametric MRI signal derived from multiple echoes that provides a level of independence from basic MRI signal variation. Here we examine the use of R2* mapping combined with slice based multi echo geometric distortion correction for in-utero studies. The challenges for R2* mapping arise from the relatively low signal strength of in-utero data. In this paper we focus on comparing activation detection in-utero using T2W and R2* approaches. We make use a subset of studies with relatively limited motion to compare the activation patterns without the additional confound of significant motion. Results at different gestational ages indicate comparable agreement in many activation patterns when limited motion is present, and the detection of some additional networks in the R2* data, not seen in the T2W results.

  13. RESTful Web Services Cookbook

    CERN Document Server

    Allamaraju, Subbu

    2010-01-01

    While the REST design philosophy has captured the imagination of web and enterprise developers alike, using this approach to develop real web services is no picnic. This cookbook includes more than 100 recipes to help you take advantage of REST, HTTP, and the infrastructure of the Web. You'll learn ways to design RESTful web services for client and server applications that meet performance, scalability, reliability, and security goals, no matter what programming language and development framework you use. Each recipe includes one or two problem statements, with easy-to-follow, step-by-step i

  14. New numerical approximation of fractional derivative with non-local and non-singular kernel: Application to chaotic models

    Science.gov (United States)

    Toufik, Mekkaoui; Atangana, Abdon

    2017-10-01

    Recently a new concept of fractional differentiation with non-local and non-singular kernel was introduced in order to extend the limitations of the conventional Riemann-Liouville and Caputo fractional derivatives. A new numerical scheme has been developed, in this paper, for the newly established fractional differentiation. We present in general the error analysis. The new numerical scheme was applied to solve linear and non-linear fractional differential equations. We do not need a predictor-corrector to have an efficient algorithm, in this method. The comparison of approximate and exact solutions leaves no doubt believing that, the new numerical scheme is very efficient and converges toward exact solution very rapidly.

  15. Meta-analytically informed network analysis of resting state FMRI reveals hyperconnectivity in an introspective socio-affective network in depression.

    Directory of Open Access Journals (Sweden)

    Leonhard Schilbach

    Full Text Available Alterations of social cognition and dysfunctional interpersonal expectations are thought to play an important role in the etiology of depression and have, thus, become a key target of psychotherapeutic interventions. The underlying neurobiology, however, remains elusive. Based upon the idea of a close link between affective and introspective processes relevant for social interactions and alterations thereof in states of depression, we used a meta-analytically informed network analysis to investigate resting-state functional connectivity in an introspective socio-affective (ISA network in individuals with and without depression. Results of our analysis demonstrate significant differences between the groups with depressed individuals showing hyperconnectivity of the ISA network. These findings demonstrate that neurofunctional alterations exist in individuals with depression in a neural network relevant for introspection and socio-affective processing, which may contribute to the interpersonal difficulties that are linked to depressive symptomatology.

  16. Investigation of True High Frequency Electrical Substrates of fMRI-Based Resting State Networks Using Parallel Independent Component Analysis of Simultaneous EEG/fMRI Data.

    Science.gov (United States)

    Kyathanahally, Sreenath P; Wang, Yun; Calhoun, Vince D; Deshpande, Gopikrishna

    2017-01-01

    Previous work using simultaneously acquired electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data has shown that the slow temporal dynamics of resting state brain networks (RSNs), e.g., default mode network (DMN), visual network (VN), obtained from fMRI are correlated with smoothed and down sampled versions of various EEG features such as microstates and band-limited power envelopes. Therefore, even though the down sampled and smoothed envelope of EEG gamma band power is correlated with fMRI fluctuations in the RSNs, it does not mean that the electrical substrates of the RSNs fluctuate with periods state fMRI fluctuations in the RSNs, researchers have speculated that truly high frequency electrical substrates may exist for the RSNs, which would make resting fluctuations obtained from fMRI more meaningful to typically occurring fast neuronal processes in the sub-100 ms time scale. In this study, we test this critical hypothesis using an integrated framework involving simultaneous EEG/fMRI acquisition, fast fMRI sampling ( TR = 200 ms) using multiband EPI (MB EPI), and EEG/fMRI fusion using parallel independent component analysis (pICA) which does not require the down sampling of EEG to fMRI temporal resolution . Our results demonstrate that with faster sampling, high frequency electrical substrates (fluctuating with periods <100 ms time scale) of the RSNs can be observed. This provides a sounder neurophysiological basis for the RSNs.

  17. Multi-atlas labeling with population-specific template and non-local patch-based label fusion

    DEFF Research Database (Denmark)

    Fonov, Vladimir; Coupé, Pierrick; Eskildsen, Simon Fristed

    We propose a new method combining a population-specific nonlinear template atlas approach with non-local patch-based structure segmentation for whole brain segmentation into individual structures. This way, we benefit from the efficient intensity-driven segmentation of the non-local means framework...... and from the global shape constraints imposed by the nonlinear template matching....

  18. One-dimensional, non-local, first-order, stationary mean-field games with congestion: a Fourier approach

    KAUST Repository

    Nurbekyan, Levon

    2017-03-11

    Here, we study a one-dimensional, non-local mean-field game model with congestion. When the kernel in the non-local coupling is a trigonometric polynomial we reduce the problem to a finite dimensional system. Furthermore, we treat the general case by approximating the kernel with trigonometric polynomials. Our technique is based on Fourier expansion methods.

  19. One-dimensional, non-local, first-order, stationary mean-field games with congestion: a Fourier approach

    KAUST Repository

    Nurbekyan, Levon

    2017-01-01

    Here, we study a one-dimensional, non-local mean-field game model with congestion. When the kernel in the non-local coupling is a trigonometric polynomial we reduce the problem to a finite dimensional system. Furthermore, we treat the general case by approximating the kernel with trigonometric polynomials. Our technique is based on Fourier expansion methods.

  20. Deriving appropriate boundary conditions, and accelerating position-jump simulations, of diffusion using non-local jumping

    International Nuclear Information System (INIS)

    Taylor, P R; Baker, R E; Yates, C A

    2015-01-01

    In this paper we explore lattice-based position-jump models of diffusion, and the implications of introducing non-local jumping; particles can jump to a range of nearby boxes rather than only to their nearest neighbours. We begin by deriving conditions for equivalence with traditional local jumping models in the continuum limit. We then generalize a previously postulated implementation of the Robin boundary condition for a non-local process of arbitrary maximum jump length, and present a novel implementation of flux boundary conditions, again generalized for a non-local process of arbitrary maximum jump length. In both these cases we validate our results using stochastic simulation. We then proceed to consider two variations on the basic diffusion model: a hybrid local/non-local scheme suitable for models involving sharp concentration gradients, and the implementation of biased jumping. In all cases we show that non-local jumping can deliver substantial time savings for stochastic simulations. (paper)

  1. Dynamic Functional Connectivity States Between the Dorsal and Ventral Sensorimotor Networks Revealed by Dynamic Conditional Correlation Analysis of Resting-State Functional Magnetic Resonance Imaging.

    Science.gov (United States)

    Syed, Maleeha F; Lindquist, Martin A; Pillai, Jay J; Agarwal, Shruti; Gujar, Sachin K; Choe, Ann S; Caffo, Brian; Sair, Haris I

    2017-12-01

    Functional connectivity in resting-state functional magnetic resonance imaging (rs-fMRI) has received substantial attention since the initial findings of Biswal et al. Traditional network correlation metrics assume that the functional connectivity in the brain remains stationary over time. However, recent studies have shown that robust temporal fluctuations of functional connectivity among as well as within functional networks exist, challenging this assumption. In this study, these dynamic correlation differences were investigated between the dorsal and ventral sensorimotor networks by applying the dynamic conditional correlation model to rs-fMRI data of 20 healthy subjects. k-Means clustering was used to determine an optimal number of discrete connectivity states (k = 10) of the sensorimotor system across all subjects. Our analysis confirms the existence of differences in dynamic correlation between the dorsal and ventral networks, with highest connectivity found within the ventral motor network.

  2. Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI.

    Science.gov (United States)

    Wang, Kun; Jiang, Tianzi; Liang, Meng; Wang, Liang; Tian, Lixia; Zhang, Xinqing; Li, Kuncheng; Liu, Zhening

    2006-01-01

    In this work, we proposed a discriminative model of Alzheimer's disease (AD) on the basis of multivariate pattern classification and functional magnetic resonance imaging (fMRI). This model used the correlation/anti-correlation coefficients of two intrinsically anti-correlated networks in resting brains, which have been suggested by two recent studies, as the feature of classification. Pseudo-Fisher Linear Discriminative Analysis (pFLDA) was then performed on the feature space and a linear classifier was generated. Using leave-one-out (LOO) cross validation, our results showed a correct classification rate of 83%. We also compared the proposed model with another one based on the whole brain functional connectivity. Our proposed model outperformed the other one significantly, and this implied that the two intrinsically anti-correlated networks may be a more susceptible part of the whole brain network in the early stage of AD.

  3. Non-Local Sparse Image Inpainting for Document Bleed-Through Removal

    Directory of Open Access Journals (Sweden)

    Muhammad Hanif

    2018-05-01

    Full Text Available Bleed-through is a frequent, pervasive degradation in ancient manuscripts, which is caused by ink seeped from the opposite side of the sheet. Bleed-through, appearing as an extra interfering text, hinders document readability and makes it difficult to decipher the information contents. Digital image restoration techniques have been successfully employed to remove or significantly reduce this distortion. This paper proposes a two-step restoration method for documents affected by bleed-through, exploiting information from the recto and verso images. First, the bleed-through pixels are identified, based on a non-stationary, linear model of the two texts overlapped in the recto-verso pair. In the second step, a dictionary learning-based sparse image inpainting technique, with non-local patch grouping, is used to reconstruct the bleed-through-contaminated image information. An overcomplete sparse dictionary is learned from the bleed-through-free image patches, which is then used to estimate a befitting fill-in for the identified bleed-through pixels. The non-local patch similarity is employed in the sparse reconstruction of each patch, to enforce the local similarity. Thanks to the intrinsic image sparsity and non-local patch similarity, the natural texture of the background is well reproduced in the bleed-through areas, and even a possible overestimation of the bleed through pixels is effectively corrected, so that the original appearance of the document is preserved. We evaluate the performance of the proposed method on the images of a popular database of ancient documents, and the results validate the performance of the proposed method compared to the state of the art.

  4. Quantum objects non-local correlation, causality and objective indefiniteness in the quantum world

    CERN Document Server

    Jaeger, Gregg

    2013-01-01

    This monograph identifies the essential characteristics of the objects described by current quantum theory and considers their relationship to space-time. In the process, it explicates the senses in which quantum objects may be consistently considered to have parts of which they may be composed or into which they may be decomposed. The book also demonstrates the degree to which reduction is possible in quantum mechanics, showing it to be related to the objective indefiniteness of quantum properties and the strong non-local correlations that can occur between the physical quantities of quantum

  5. Quantum non-locality in a two-slit interferometer for short-lived particles

    International Nuclear Information System (INIS)

    Klein, Spencer R.; Nystrand, Joakim

    2001-01-01

    We describe a new test of quantum nonlocality, using an interferometer for short-lived particles. The separation is large compared with the particle lifetimes. This interferometer is realized by vector meson production in distant heavy ion collisions. The mesons decay before waves from the two sources (ions) can overlap, so interference is only possible among the decay products. The post-decay wave function must retain amplitudes for all possible decays. The decay products are spatially separated, necessitating a non-local wave function. The interference is measurable by summing the product momenta. Alternately, the products positions could be observed, allowing new tests of the EPR paradox

  6. Tests of non-local interferences in kaon physics at asymmetric φ-factories

    International Nuclear Information System (INIS)

    Eberhard, P.H.

    1993-01-01

    Tests of non-local interference effects in the two-kaon system are proposed. The first kind of tests consists of measuring the amount of destructive interference between K S → K L regeneration processes of two distant kaons. The second kind deals with constructive interference. These tests could be performed at an asymmetric φ-factory. Estimates are given of the number of events predicted by orthodox quantum mechanics and kaon regeneration theory in various suitable experimental conditions. The impact on local theories if the predictions of quantum mechanics hold is discussed

  7. Non-local ground-state functional for quantum spin chains with translational broken symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Libero, Valter L.; Penteado, Poliana H.; Veiga, Rodrigo S. [Universidade de Sao Paulo (IFSC/USP), Sao Carlos, SP (Brazil). Inst. de Fisica

    2011-07-01

    Full text. Thanks to the development and use of new materials with special doping, it becomes relevant the study of Heisenberg spin-chains with broken translational symmetry, induced for instance by finite-size effects, bond defects or by impurity spin in the chain. The exact numerical results demands huge computational efforts, due to the size of the Hilbert space involved and the lack of symmetry to exploit. Density Functional Theory (DFT) has been considered a simple alternative to obtain ground-state properties for such systems. Usually, DFT starts with a uniform system to build the correlation energy and after implement a local approximation to construct local functionals. Based on our prove of the Hohenberg-Kohn theorem for Heisenberg models, and in order to describe more realistic models, we have recently developed a non-local exchange functional for the ground-state energy of quantum-spin chains. A alternating-bond chain is used to obtain the correlation energy and a local unit-cell approximation - LUCA, is defined in the context of DFT. The alternating chain is a good starting point to construct functionals since it is intrinsically non-homogeneous, therefore instead of the usual local approximation (like LDA for electronic systems) we need to introduce an approximation based upon a unit cell concept, that renders a non-local functional in the bond exchange interaction. The agreement with exact numerical data (obtained only for small chains, although the functional can be applied for chains with arbitrary size) is significantly better than in our previous local formulation, even for chains with several ferromagnetic or antiferromagnetic bond defects. These results encourage us to extend the concept of LUCA for chains with alternating-spin magnitudes. We also have constructed a non-local functional based on an alternating-spin chain, instead of a local alternating-bond, using spin-wave-theory. Because of its non-local nature, this functional is expected to

  8. Quantum non-locality and relativity metaphysical intimations of modern physics

    CERN Document Server

    Maudlin, Tim

    2011-01-01

    The third edition of Quantum Non-Locality and Relativity has been carefully updated to reflect significant developments, including a new chapter covering important recent work in the foundations of physics. A new edition of the premier philosophical study of Bell's Theorem and its implication for the relativistic account of space and timeDiscusses Roderich Tumiulka's explicit, relativistic theory that can reproduce the quantum mechanical violation of Bell's inequality. Discusses the "Free Will Theorem" of John Conway and Simon KochenIntroduces philosophers to the relevant physics and demonstra

  9. Algebraic Traveling Wave Solutions of a Non-local Hydrodynamic-type Model

    International Nuclear Information System (INIS)

    Chen, Aiyong; Zhu, Wenjing; Qiao, Zhijun; Huang, Wentao

    2014-01-01

    In this paper we consider the algebraic traveling wave solutions of a non-local hydrodynamic-type model. It is shown that algebraic traveling wave solutions exist if and only if an associated first order ordinary differential system has invariant algebraic curve. The dynamical behavior of the associated ordinary differential system is analyzed. Phase portraits of the associated ordinary differential system is provided under various parameter conditions. Moreover, we classify algebraic traveling wave solutions of the model. Some explicit formulas of smooth solitary wave and cuspon solutions are obtained

  10. Non-local ground-state functional for quantum spin chains with translational broken symmetry

    International Nuclear Information System (INIS)

    Libero, Valter L.; Penteado, Poliana H.; Veiga, Rodrigo S.

    2011-01-01

    Full text. Thanks to the development and use of new materials with special doping, it becomes relevant the study of Heisenberg spin-chains with broken translational symmetry, induced for instance by finite-size effects, bond defects or by impurity spin in the chain. The exact numerical results demands huge computational efforts, due to the size of the Hilbert space involved and the lack of symmetry to exploit. Density Functional Theory (DFT) has been considered a simple alternative to obtain ground-state properties for such systems. Usually, DFT starts with a uniform system to build the correlation energy and after implement a local approximation to construct local functionals. Based on our prove of the Hohenberg-Kohn theorem for Heisenberg models, and in order to describe more realistic models, we have recently developed a non-local exchange functional for the ground-state energy of quantum-spin chains. A alternating-bond chain is used to obtain the correlation energy and a local unit-cell approximation - LUCA, is defined in the context of DFT. The alternating chain is a good starting point to construct functionals since it is intrinsically non-homogeneous, therefore instead of the usual local approximation (like LDA for electronic systems) we need to introduce an approximation based upon a unit cell concept, that renders a non-local functional in the bond exchange interaction. The agreement with exact numerical data (obtained only for small chains, although the functional can be applied for chains with arbitrary size) is significantly better than in our previous local formulation, even for chains with several ferromagnetic or antiferromagnetic bond defects. These results encourage us to extend the concept of LUCA for chains with alternating-spin magnitudes. We also have constructed a non-local functional based on an alternating-spin chain, instead of a local alternating-bond, using spin-wave-theory. Because of its non-local nature, this functional is expected to

  11. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes

    DEFF Research Database (Denmark)

    Zhao, Xiaolu; Leon, Ileana R; Bak, Steffen

    2011-01-01

    . In skeletal muscle, mitochondrial dysfunction is linked to insulin resistance in humans with obesity and type 2 diabetes. We performed a phosphoproteomic study of functional mitochondria isolated from human muscle biopsies with the aim to obtain a comprehensive overview of mitochondrial phosphoproteins...... in insulin resistance. We also assigned phosphorylation sites in mitochondrial proteins involved in amino acid degradation, importers and transporters, calcium homeostasis, and apoptosis. Bioinformatics analysis of kinase motifs revealed that many of these mitochondrial phosphoproteins are substrates....... Future comparative phosphoproteome analysis of mitochondria from healthy and diseased individuals will provide insights into the role of abnormal phosphorylation in pathologies, such as type 2 diabetes....

  12. A non-local structural derivative model for characterization of ultraslow diffusion in dense colloids

    Science.gov (United States)

    Liang, Yingjie; Chen, Wen

    2018-03-01

    Ultraslow diffusion has been observed in numerous complicated systems. Its mean squared displacement (MSD) is not a power law function of time, but instead a logarithmic function, and in some cases grows even more slowly than the logarithmic rate. The distributed-order fractional diffusion equation model simply does not work for the general ultraslow diffusion. Recent study has used the local structural derivative to describe ultraslow diffusion dynamics by using the inverse Mittag-Leffler function as the structural function, in which the MSD is a function of inverse Mittag-Leffler function. In this study, a new stretched logarithmic diffusion law and its underlying non-local structural derivative diffusion model are proposed to characterize the ultraslow diffusion in aging dense colloidal glass at both the short and long waiting times. It is observed that the aging dynamics of dense colloids is a class of the stretched logarithmic ultraslow diffusion processes. Compared with the power, the logarithmic, and the inverse Mittag-Leffler diffusion laws, the stretched logarithmic diffusion law has better precision in fitting the MSD of the colloidal particles at high densities. The corresponding non-local structural derivative diffusion equation manifests clear physical mechanism, and its structural function is equivalent to the first-order derivative of the MSD.

  13. A non-local shell model of hydrodynamic and magnetohydrodynamic turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Plunian, F [Laboratoire de Geophysique Interne et Tectonophysique, CNRS, Universite Joseph Fourier, Maison des Geosciences, BP 53, 38041 Grenoble Cedex 9 (France); Stepanov, R [Institute of Continuous Media Mechanics, Korolyov 1, 614013 Perm (Russian Federation)

    2007-08-15

    We derive a new shell model of magnetohydrodynamic (MHD) turbulence in which the energy transfers are not necessarily local. Like the original MHD equations, the model conserves the total energy, magnetic helicity, cross-helicity and volume in phase space (Liouville's theorem) apart from the effects of external forcing, viscous dissipation and magnetic diffusion. The model of hydrodynamic (HD) turbulence is derived from the MHD model setting the magnetic field to zero. In that case the conserved quantities are the kinetic energy and the kinetic helicity. In addition to a statistically stationary state with a Kolmogorov spectrum, the HD model exhibits multiscaling. The anomalous scaling exponents are found to depend on a free parameter {alpha} that measures the non-locality degree of the model. In freely decaying turbulence, the infra-red spectrum also depends on {alpha}. Comparison with theory suggests using {alpha} = -5/2. In MHD turbulence, we investigate the fully developed turbulent dynamo for a wide range of magnetic Prandtl numbers in both kinematic and dynamic cases. Both local and non-local energy transfers are clearly identified.

  14. Finite-volume effects due to spatially non-local operators arXiv

    CERN Document Server

    Briceño, Raúl A.; Hansen, Maxwell T.; Monahan, Christopher J.

    Spatially non-local matrix elements are useful lattice-QCD observables in a variety of contexts, for example in determining hadron structure. To quote credible estimates of the systematic uncertainties in these calculations, one must understand, among other things, the size of the finite-volume effects when such matrix elements are extracted from numerical lattice calculations. In this work, we estimate finite-volume effects for matrix elements of non-local operators, composed of two currents displaced in a spatial direction by a distance $\\xi$. We find that the finite-volume corrections depend on the details of the matrix element. If the external state is the lightest degree of freedom in the theory, e.g.~the pion in QCD, then the volume corrections scale as $ e^{-m_\\pi (L- \\xi)} $, where $m_\\pi$ is the mass of the light state. For heavier external states the usual $e^{- m_\\pi L}$ form is recovered, but with a polynomial prefactor of the form $L^m/|L - \\xi|^n$ that can lead to enhanced volume effects. These ...

  15. A comparison of non-local electron transport models relevant to inertial confinement fusion

    Science.gov (United States)

    Sherlock, Mark; Brodrick, Jonathan; Ridgers, Christopher

    2017-10-01

    We compare the reduced non-local electron transport model developed by Schurtz et al. to Vlasov-Fokker-Planck simulations. Two new test cases are considered: the propagation of a heat wave through a high density region into a lower density gas, and a 1-dimensional hohlraum ablation problem. We find the reduced model reproduces the peak heat flux well in the ablation region but significantly over-predicts the coronal preheat. The suitability of the reduced model for computing non-local transport effects other than thermal conductivity is considered by comparing the computed distribution function to the Vlasov-Fokker-Planck distribution function. It is shown that even when the reduced model reproduces the correct heat flux, the distribution function is significantly different to the Vlasov-Fokker-Planck prediction. Two simple modifications are considered which improve agreement between models in the coronal region. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  16. Discretization independence implies non-locality in 4D discrete quantum gravity

    Science.gov (United States)

    Dittrich, Bianca; Kamiński, Wojciech; Steinhaus, Sebastian

    2014-12-01

    The 4D Regge action is invariant under 5-1 and 4-2 Pachner moves, which define a subset of (local) changes of the triangulation. Given this fact, one might hope to find a local path integral measure that makes the quantum theory invariant under these moves and hence makes the theory partially triangulation invariant. We show that such a local invariant path integral measure does not exist for the 4D linearized Regge theory. To this end we uncover an interesting geometric interpretation for the Hessian of the 4D Regge action. This geometric interpretation will allow us to prove that the determinant of the Hessian of the 4D Regge action does not factorize over four-simplices or subsimplices. It furthermore allows us to determine configurations where this Hessian vanishes, which only appears to be the case in degenerate backgrounds or if one allows for different orientations of the simplices. We suggest a non-local measure factor that absorbs the non-local part of the determinant of the Hessian under 5-1 moves as well as a local measure factor that is preserved for very special configurations.

  17. Discretization independence implies non-locality in 4D discrete quantum gravity

    International Nuclear Information System (INIS)

    Dittrich, Bianca; Kamiński, Wojciech; Steinhaus, Sebastian

    2014-01-01

    The 4D Regge action is invariant under 5–1 and 4–2 Pachner moves, which define a subset of (local) changes of the triangulation. Given this fact, one might hope to find a local path integral measure that makes the quantum theory invariant under these moves and hence makes the theory partially triangulation invariant. We show that such a local invariant path integral measure does not exist for the 4D linearized Regge theory. To this end we uncover an interesting geometric interpretation for the Hessian of the 4D Regge action. This geometric interpretation will allow us to prove that the determinant of the Hessian of the 4D Regge action does not factorize over four-simplices or subsimplices. It furthermore allows us to determine configurations where this Hessian vanishes, which only appears to be the case in degenerate backgrounds or if one allows for different orientations of the simplices. We suggest a non-local measure factor that absorbs the non-local part of the determinant of the Hessian under 5–1 moves as well as a local measure factor that is preserved for very special configurations. (paper)

  18. On non-local energy transfer via zonal flow in the Dimits shift

    International Nuclear Information System (INIS)

    St-Onge, Denis A.

    2017-01-01

    The two-dimensional Terry–Horton equation is shown to exhibit the Dimits shift when suitably modified to capture both the nonlinear enhancement of zonal/drift-wave interactions and the existence of residual Rosenbluth–Hinton states. This phenomenon persists through numerous simplifications of the equation, including a quasilinear approximation as well as a four-mode truncation. It is shown that the use of an appropriate adiabatic electron response, for which the electrons are not affected by the flux-averaged potential, results in an E×B nonlinearity that can efficiently transfer energy non-locally to length scales of the order of the sound radius. The size of the shift for the nonlinear system is heuristically calculated and found to be in excellent agreement with numerical solutions. The existence of the Dimits shift for this system is then understood as an ability of the unstable primary modes to efficiently couple to stable modes at smaller scales, and the shift ends when these stable modes eventually destabilize as the density gradient is increased. This non-local mechanism of energy transfer is argued to be generically important even for more physically complete systems.

  19. On non-local energy transfer via zonal flow in the Dimits shift

    Science.gov (United States)

    St-Onge, Denis A.

    2017-10-01

    The two-dimensional Terry-Horton equation is shown to exhibit the Dimits shift when suitably modified to capture both the nonlinear enhancement of zonal/drift-wave interactions and the existence of residual Rosenbluth-Hinton states. This phenomenon persists through numerous simplifications of the equation, including a quasilinear approximation as well as a four-mode truncation. It is shown that the use of an appropriate adiabatic electron response, for which the electrons are not affected by the flux-averaged potential, results in an nonlinearity that can efficiently transfer energy non-locally to length scales of the order of the sound radius. The size of the shift for the nonlinear system is heuristically calculated and found to be in excellent agreement with numerical solutions. The existence of the Dimits shift for this system is then understood as an ability of the unstable primary modes to efficiently couple to stable modes at smaller scales, and the shift ends when these stable modes eventually destabilize as the density gradient is increased. This non-local mechanism of energy transfer is argued to be generically important even for more physically complete systems.

  20. Comparative analysis between academic and patent publications based on Fenton Technologies among China, Brazil, and the rest of the world.

    Science.gov (United States)

    de Luna, Airton José; Santos, Douglas Alves

    2017-03-01

    Worldwide, year by year, Fenton's Technologies have been highlighted in both academic and patent scopes, in part due to their proven efficiency as environment-friendly technologies destined to the abatement of organic pollutants, and also by their growing interest to produce industrial applications. Thus, aiming to understand the effective dynamic between two worlds, academy vs patents, the present study performs a comparative analysis about publications on Fenton-based Technologies (FbT). Therefore, in this work, technological foresight techniques were adopted focusing on patent and non-patent databases, employing for this, the Web of Science (WoS) database as a prospecting tool. The main results for the last decade point out to a strong increment of the Fenton's Technologies, as much in R&D as in patent applications in the world. Chinese Universities and firms command the scenario. There is an expressive gap between the academic and patent issues.

  1. REST based service composition

    DEFF Research Database (Denmark)

    Grönvall, Erik; Ingstrup, Mads; Pløger, Morten

    2011-01-01

    This paper presents an ongoing work developing and testing a Service Composition framework based upon the REST architecture named SECREST. A minimalistic approach have been favored instead of a creating a complete infrastructure. One focus has been on the system's interaction model. Indeed, an aim...

  2. Usefulness of rest-redistribution on thallium myocardial scintigraphy in patients with acute myocardial infarction by SPECT; Analysis by bull's eye and unfolded map images

    Energy Technology Data Exchange (ETDEWEB)

    Tahara, Yorio; Taya, Makoto; Sasaki, Akira; Nishimura, Tooru; Shimoyama, Katsuya; Mizuno, Haruyoshi; Ono, Akifumi; Okada, Michio; Ishikawa, Kyozo (Kyorin Univ., Mitaka, Tokyo (Japan). School of Medicine)

    1990-01-01

    The purpose of this study was to clarify the clinical significance of rest-redistribution in myocardial scintigraphy (SPECT) in acute myocardial infarction (AMI). 30 patients with AMI within one week after the onset of attack were studied. SPECT images were obtained 10 min and 3hrs after injection of {sup 201}Tl. Bull's eye images and unfolded map images were prepared. A {sup 201}Tl uptake was studied at the infarct and non-infarct sites. Exercise SPECT and radionuclide angiography were performed in all patients one month after the onset of AMI, and the findings were compared with clinical and coronary angiographic (CAG) findings. Redistribution of Tl at rest was observed at the infarct sites in 9 of the 30 patients. Redistribution at rest was observed at the non-infarct sites in 8 patients. Redistribution at rest was observed during exercise SPECT one month after the onset of AMI in patients with redistribution at rest in the acute phase. In patients with redistribution at rest at the infarct site, left ventricular ejection fraction (EF) improved one month after the onset of AMI ({Delta}EF>5%), but it decreased slightly during exercise. Wall motion at the infarct site was not much impaired in patients who showed redistribution at rest at the infarct site. Angina pectoris and recurrence of myocardial infarction were observed more frequently on SPECT, but no characteristic findings were obtained on CAG in those with redistribution at rest. In conclusion, cardiac function and wall motion at the infarct site are better preserved in patients with redistribution of Tl at rest on SPECT in the acute stage of myocardial infarction, as compared with patients having fixed defects, but the EF decrease slightly during exercise and the frequency of post-infarction angina is greater in those patients. Resting SPECT in AMI is considered to provide useful information for predicting cardiac function and the clinical course following myocardial infarction. (author).

  3. An in silico analysis of oxygen uptake of a mild COPD patient during rest and exercise using a portable oxygen concentrator

    Directory of Open Access Journals (Sweden)

    Katz I

    2016-09-01

    Full Text Available Ira Katz,1,2 Marine Pichelin,1 Spyridon Montesantos,1 Min-Yeong Kang,3 Bernard Sapoval,3,4 Kaixian Zhu,5 Charles-Philippe Thevenin,5 Robert McCoy,6 Andrew R Martin,7 Georges Caillibotte1 1Medical R&D, Air Liquide Santé International, Centre de Recherche Paris-Saclay, Les Loges-en-Josas, France; 2Department of Mechanical Engineering, Lafayette College, Easton, PA, USA; 3Physique de la Matière Condensée, CNRS, Ecole Polytechnique, Palaiseau, 4Centre de Mathématiques et de leurs Applications, CNRS, UniverSud, Cachan, 5Centre Explor!, Air Liquide Healthcare, Gentilly, France; 6Valley Inspired Products, Inc, Apple Valley, MN, USA; 7Department of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada Abstract: Oxygen treatment based on intermittent-flow devices with pulse delivery modes available from portable oxygen concentrators (POCs depends on the characteristics of the delivered pulse such as volume, pulse width (the time of the pulse to be delivered, and pulse delay (the time for the pulse to be initiated from the start of inhalation as well as a patient’s breathing characteristics, disease state, and respiratory morphology. This article presents a physiological-based analysis of the performance, in terms of blood oxygenation, of a commercial POC at different settings using an in silico model of a COPD patient at rest and during exercise. The analysis encompasses experimental measurements of pulse volume, width, and time delay of the POC at three different settings and two breathing rates related to rest and exercise. These experimental data of device performance are inputs to a physiological-based model of oxygen uptake that takes into account the real dynamic nature of gas exchange to illustrate how device- and patient-specific factors can affect patient oxygenation. This type of physiological analysis that considers the true effectiveness of oxygen transfer to the blood, as opposed to delivery to the nose (or mouth, can be

  4. Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis

    Directory of Open Access Journals (Sweden)

    Jungho Cha

    2015-01-01

    Full Text Available Resting-state functional magnetic resonance imaging (RS FMRI has been widely used to analyze functional alterations in amnestic mild cognitive impairment (aMCI and Alzheimer’s disease (AD patients. Although many clinical studies of aMCI and AD patients using RS FMRI have been undertaken, conducting a meta-analysis has not been easy because of seed selection bias by the investigators. The purpose of our study was to investigate the functional differences in aMCI and AD patients compared with healthy subjects in a meta-analysis. Thus, a multimethod approach using regional homogeneity, amplitude of low-frequency fluctuation (ALFF, fractional ALFF (fALFF, and global brain connectivity was used to investigate differences between three groups based on previously published data. According to the choice of RS FMRI approach used, the patterns of functional alteration were slightly different. Nevertheless, patients with aMCI and AD displayed consistently decreased functional characteristics with all approaches. All approaches showed that the functional characteristics in the left parahippocampal gyrus were decreased in AD patients compared with healthy subjects. Although some regions were slightly different according to the different RS FMRI approaches, patients with aMCI and AD showed a consistent pattern of decreased functional characteristics with all approaches.

  5. Stability of stationary states of non-local equations with singular interaction potentials

    KAUST Repository

    Fellner, Klemens

    2011-04-01

    We study the large-time behaviour of a non-local evolution equation for the density of particles or individuals subject to an external and an interaction potential. In particular, we consider interaction potentials which are singular in the sense that their first derivative is discontinuous at the origin.For locally attractive singular interaction potentials we prove under a linear stability condition local non-linear stability of stationary states consisting of a finite sum of Dirac masses. For singular repulsive interaction potentials we show the stability of stationary states of uniformly bounded solutions under a convexity condition.Finally, we present numerical simulations to illustrate our results. © 2010 Elsevier Ltd.

  6. Towards a resolution of the cosmological singularity in non-local higher derivative theories of gravity

    International Nuclear Information System (INIS)

    Biswas, Tirthabir; Koivisto, Tomi; Mazumdar, Anupam

    2010-01-01

    One of the greatest problems of standard cosmology is the Big Bang singularity. Previously it has been shown that non-local ghostfree higher-derivative modifications of Einstein gravity in the ultra-violet regime can admit non-singular bouncing solutions. In this paper we study in more details the dynamical properties of the equations of motion for these theories of gravity in presence of positive and negative cosmological constants and radiation. We find stable inflationary attractor solutions in the presence of a positive cosmological constant which renders inflation geodesically complete, while in the presence of a negative cosmological constant a cyclic universe emerges. We also provide an algorithm for tracking the super-Hubble perturbations during the bounce and show that the bouncing solutions are free from any perturbative instability

  7. Non-local energy density functionals: models plus some exact general results

    International Nuclear Information System (INIS)

    March, N.H.

    2001-02-01

    Holas and March (Phys. Rev. A51, 2040, 1995) gave a formally exact expression for the force - δV xc (r-tilde)/δr-tilde associated with the exchange-correlation potential V xc (r-tilde) of density functional theory. This forged a precise link between first- and second-order density matrices and V xc (r-tilde). Here models are presented in which these low-order matrices can be related to the ground-state electron density. This allows non-local energy density functionals to be constructed within the framework of such models. Finally, results emerging from these models have led to the derivation of some exact 'nuclear cusp' relations for exchange and correlation energy densities in molecules, clusters and condensed phases. (author)

  8. The algebra of non-local charges in non-linear sigma models

    International Nuclear Information System (INIS)

    Abdalla, E.; Abdalla, M.C.B.; Brunelli, J.C.; Zadra, A.

    1993-07-01

    We obtain the exact Dirac algebra obeyed by the conserved non-local charges in bosonic non-linear sigma models. Part of the computation is specialized for a symmetry group O(N). As it turns out the algebra corresponds to a cubic deformation of the Kac-Moody algebra. The non-linear terms are computed in closed form. In each Dirac bracket we only find highest order terms (as explained in the paper), defining a saturated algebra. We generalize the results for the presence of a Wess-Zumino term. The algebra is very similar to the previous one, containing now a calculable correction of order one unit lower. (author). 22 refs, 5 figs

  9. Random noise suppression of seismic data using non-local Bayes algorithm

    Science.gov (United States)

    Chang, De-Kuan; Yang, Wu-Yang; Wang, Yi-Hui; Yang, Qing; Wei, Xin-Jian; Feng, Xiao-Ying

    2018-02-01

    For random noise suppression of seismic data, we present a non-local Bayes (NL-Bayes) filtering algorithm. The NL-Bayes algorithm uses the Gaussian model instead of the weighted average of all similar patches in the NL-means algorithm to reduce the fuzzy of structural details, thereby improving the denoising performance. In the denoising process of seismic data, the size and the number of patches in the Gaussian model are adaptively calculated according to the standard deviation of noise. The NL-Bayes algorithm requires two iterations to complete seismic data denoising, but the second iteration makes use of denoised seismic data from the first iteration to calculate the better mean and covariance of the patch Gaussian model for improving the similarity of patches and achieving the purpose of denoising. Tests with synthetic and real data sets demonstrate that the NL-Bayes algorithm can effectively improve the SNR and preserve the fidelity of seismic data.

  10. Non-local coexistence of multiple spiral waves with independent frequencies

    International Nuclear Information System (INIS)

    Zhan Meng; Luo Jinming

    2009-01-01

    The interactions of several spiral waves with different independent rotation frequencies are studied in a model of two-dimensional complex Ginzburg-Laudau equation. We find a general coexistence phenomenon, non-local non-phase-locking-invasion coexistence, that is, the non-slowest spiral wave can survive and not be killed by the fastest spiral wave as it is insulated from the fastest one with the sacrifice of the slowest one, which stays in the spatial position between the fastest spiral and the non-slowest one. Both the parameter non-monotonicity and the non-phase-locking invasion between the fastest and the slowest spiral waves play key roles in this phenomenon. Importantly, the results could give a general idea for extensively observed coexistence of spiral waves in various inhomogeneous circumstances.

  11. Non-local statistical label fusion for multi-atlas segmentation.

    Science.gov (United States)

    Asman, Andrew J; Landman, Bennett A

    2013-02-01

    Multi-atlas segmentation provides a general purpose, fully-automated approach for transferring spatial information from an existing dataset ("atlases") to a previously unseen context ("target") through image registration. The method to resolve voxelwise label conflicts between the registered atlases ("label fusion") has a substantial impact on segmentation quality. Ideally, statistical fusion algorithms (e.g., STAPLE) would result in accurate segmentations as they provide a framework to elegantly integrate models of rater performance. The accuracy of statistical fusion hinges upon accurately modeling the underlying process of how raters err. Despite success on human raters, current approaches inaccurately model multi-atlas behavior as they fail to seamlessly incorporate exogenous intensity information into the estimation process. As a result, locally weighted voting algorithms represent the de facto standard fusion approach in clinical applications. Moreover, regardless of the approach, fusion algorithms are generally dependent upon large atlas sets and highly accurate registration as they implicitly assume that the registered atlases form a collectively unbiased representation of the target. Herein, we propose a novel statistical fusion algorithm, Non-Local STAPLE (NLS). NLS reformulates the STAPLE framework from a non-local means perspective in order to learn what label an atlas would have observed, given perfect correspondence. Through this reformulation, NLS (1) seamlessly integrates intensity into the estimation process, (2) provides a theoretically consistent model of multi-atlas observation error, and (3) largely diminishes the need for large atlas sets and very high-quality registrations. We assess the sensitivity and optimality of the approach and demonstrate significant improvement in two empirical multi-atlas experiments. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. Magnetic field in laser plasmas: non-local electron transport and reconnection

    International Nuclear Information System (INIS)

    Riquier, Raphael

    2016-01-01

    In the framework of the inertial confinement fusion, a pellet filled with the deuterium-tritium fuel is imploded, either through laser irradiation (direct drive, laser - low atomic number target interaction) or by the black body radiation from a cavity converting the laser radiation (indirect drive, laser - high atomic number target interaction). In both cases, a correct modeling of the electron transport is of first importance in order to have predictive hydro-radiative simulations. Nonetheless, it has been shown early on that the hypothesis of the linear transport are not valid in the framework of a solid target irradiated by a high power laser (I≅10 14 W/cm 2 ). This is due in part to very steep temperature gradients (kinetic effects, so-called 'non-local') and because of a magnetic field self-generated through the thermo-electric effect. Finally, the heat flux and the magnetic field are strongly coupled through two mechanisms: the advection of the field with the heat flux (Nernst effect) and the rotation and inhibition of the heat flux by the plasma's magnetization (Righi-Leduc effect).In this manuscript, we will first present the various electron transport models, particularly the non-local with magnetic field model included in the hydro-radiative code FCI2. Following, in order to validate this model, we will compare it first against a kinetic code, and then with an experiment during which the magnetic field has been probed through proton radiography. Once the model validated, we will use FCI2 simulations to explain the source and transport of the field, as well as its effect on the interaction. Finally, the reconnection of the magnetic field, during the irradiation of a solid target by two laser beams, will be studied. (author) [fr

  13. Occurrence of exact R{sup 2} inflation in non-local UV-complete gravity

    Energy Technology Data Exchange (ETDEWEB)

    Koshelev, Alexey S. [Departamento de Física and Centro de Matemática e Aplicações (CMA-UBI),Universidade da Beira Interior, 6200 Covilhã (Portugal); Theoretische Natuurkunde, Vrije Universiteit Brussel, and The International Solvay Institutes,Pleinlaan 2, B-1050 Brussels (Belgium); Modesto, Leonardo [Department of Physics, Southern University of Science and Technology, Shenzhen 518055 (China); Department of Physics & Center for Field Theory and Particle Physics, Fudan University,200433 Shanghai (China); Rachwał, Lesław [Department of Physics & Center for Field Theory and Particle Physics, Fudan University,200433 Shanghai (China); Starobinsky, Alexei A. [L.D. Landau Institute for Theoretical Physics RAS, Moscow 119334 (Russian Federation); Kazan Federal University, Kazan 420008, Republic of Tatarstan (Russian Federation)

    2016-11-10

    The R+R{sup 2}, shortly named “R{sup 2}” (“Starobinsky”) inflationary model, represents a fully consistent example of a one-parameter inflationary scenario. This model has a “graceful exit” from inflation and provides a mechanism for subsequent creation and final thermalization of the standard matter. Moreover, it produces a very good fit of the observed spectrum of primordial perturbations. In the present paper we show explicitly that the R{sup 2} inflationary spacetime is an exact solution of a range of weakly non-local (quasi-polynomial) gravitational theories, which provide an ultraviolet completion of the R{sup 2} theory. These theories are ghost-free, super-renormalizable or finite at quantum level, and perturbatively unitary. Their spectrum consists of the graviton and the scalaron that is responsible for driving the inflation. Notably, any further extension of the spectrum leads to propagating ghost degrees of freedom. We are aimed at presenting a detailed construction of such theories in the so called Weyl basis. Further, we give a special account to the cosmological implications of this theory by considering perturbations during inflation. The highlight of the non-local model is the prediction of a modified, in comparison to a local R{sup 2} model, value for the ratio of tensor and scalar power spectra r, depending on the parameters of the theory. The relevant parameters are under control to be successfully confronted with existing observational data. Furthermore, the modified r can surely meet future observational constraints.

  14. Relativistic entanglement from relativistic quantum mechanics in the rest-frame instant form of dynamics

    International Nuclear Information System (INIS)

    Lusanna, Luca

    2011-01-01

    After a review of the problems induced by the Lorentz signature of Minkowski space-time, like the need of a clock synchronization convention for the definition of 3-space and the complexity of the notion of relativistic center of mass, there is the introduction of a new formulation of relativistic quantum mechanics compatible with the theory of relativistic bound states. In it the zeroth postulate of non-relativistic quantum mechanics is not valid and the physics is described in the rest frame by a Hilbert space containing only relative variables. The non-locality of the Poincare' generators imply a kinematical non-locality and non-separability influencing the theory of relativistic entanglement and not connected with the standard quantum non-locality.

  15. Nano-scale mass sensor based on the vibration analysis of a magneto-electro-elastic nanoplate resting on a visco-Pasternak substrate

    Science.gov (United States)

    Khanmirza, E.; Jamalpoor, A.; Kiani, A.

    2017-10-01

    In this paper, a magneto-electro-elastic nanoplate resting on a visco-Pasternak medium with added concentrated nanoparticles is presented as a mass nanosensor according to the vibration analysis. The MEE nanoplate is supposed to be subject to external electric voltage and magnetic potential. In order to take into account the size effect on the sensitivity of the sensor, the nonlocal elasticity theory in conjunction with the Kirchhoff plate theory is applied. Partial differential equations are derived by implementing Hamilton's variational principle. Equilibrium equations were solved analytically to determine an explicit closed-form statement for both the damped frequency shift and the relative damped frequency shift using Navier's approach. A genetic algorithm (GA) is employed to achieve the optimal added nanoparticle location to gain the most sensitivity performance of the nanosensor. Numerical studies are performed to illustrate the variation of the sensitivity property corresponding to various values of the number of attached nanoparticles, the mass of each nanoparticle, the nonlocal parameter, external electric voltage and magnetic potential, the aspect ratio, and visco-Pasternak parameters. Some numerical outcomes of this paper show that the minimum value of the damped frequency shift occurs for a certain value of the length-to-thickness ratio. Also, it is shown that the external magnetic and external electric potentials have a different effect on the sensitivity property. It is anticipated that the results reported in this work can be considered as a benchmark in future micro-structures issues.

  16. Free vibration and biaxial buckling analysis of magneto-electro-elastic microplate resting on visco-Pasternak substrate via modified strain gradient theory

    Science.gov (United States)

    Jamalpoor, A.; Ahmadi-Savadkoohi, A.; Hosseini-Hashemi, Sh

    2016-10-01

    This paper deals with the theoretical analysis of free vibration and biaxial buckling of magneto-electro-elastic (MEE) microplate resting on Kelvin-Voigt visco-Pasternak foundation and subjected to initial external electric and magnetic potentials, using modified strain gradient theory (MSGT). Kirchhoff plate model and Hamilton’s principle are employed to extract the governing equations of motion. Governing equations were analytically solved to obtain clear closed-form expression for complex natural frequencies and buckling loads using Navier’s approach. Numerical results are presented to reveal variations of natural frequency and buckling load ratio of MEE microplate against different amounts of the length scale parameter, initial external electric and magnetic potentials, aspect ratio, damping and transverse and shear stiffness parameters of the visco-Pasternak foundation, length to thickness ratio, microplate thickness and higher modes. Numerical results of this study illustrate that by increasing thickness-to-material length scale parameter ratio, both natural frequency and buckling load ratio predicted by MSGT and modified couple stress theory are reduced because the non-dimensional length scale parameter tends to decrease the stiffness of structures and make them more flexible. In addition, results show that initial external electric and initial external magnetic potentials have no considerable influence on the buckling load ratio and frequency of MEE microplate as the microplate thickness increases.

  17. XQ-NLM: Denoising Diffusion MRI Data via x-q Space Non-Local Patch Matching.

    Science.gov (United States)

    Chen, Geng; Wu, Yafeng; Shen, Dinggang; Yap, Pew-Thian

    2016-10-01

    Noise is a major issue influencing quantitative analysis in diffusion MRI. The effects of noise can be reduced by repeated acquisitions, but this leads to long acquisition times that can be unrealistic in clinical settings. For this reason, post-acquisition denoising methods have been widely used to improve SNR. Among existing methods, non-local means (NLM) has been shown to produce good image quality with edge preservation. However, currently the application of NLM to diffusion MRI has been mostly focused on the spatial space (i.e., the x -space), despite the fact that diffusion data live in a combined space consisting of the x -space and the q -space (i.e., the space of wavevectors). In this paper, we propose to extend NLM to both x -space and q -space. We show how patch-matching, as required in NLM, can be performed concurrently in x-q space with the help of azimuthal equidistant projection and rotation invariant features. Extensive experiments on both synthetic and real data confirm that the proposed x-q space NLM (XQ-NLM) outperforms the classic NLM.

  18. REST: a toolkit for resting-state functional magnetic resonance imaging data processing.

    Directory of Open Access Journals (Sweden)

    Xiao-Wei Song

    Full Text Available Resting-state fMRI (RS-fMRI has been drawing more and more attention in recent years. However, a publicly available, systematically integrated and easy-to-use tool for RS-fMRI data processing is still lacking. We developed a toolkit for the analysis of RS-fMRI data, namely the RESting-state fMRI data analysis Toolkit (REST. REST was developed in MATLAB with graphical user interface (GUI. After data preprocessing with SPM or AFNI, a few analytic methods can be performed in REST, including functional connectivity analysis based on linear correlation, regional homogeneity, amplitude of low frequency fluctuation (ALFF, and fractional ALFF. A few additional functions were implemented in REST, including a DICOM sorter, linear trend removal, bandpass filtering, time course extraction, regression of covariates, image calculator, statistical analysis, and slice viewer (for result visualization, multiple comparison correction, etc.. REST is an open-source package and is freely available at http://www.restfmri.net.

  19. Graph Theoretical Analysis of Functional Brain Networks: Test-Retest Evaluation on Short- and Long-Term Resting-State Functional MRI Data

    Science.gov (United States)

    Wang, Jin-Hui; Zuo, Xi-Nian; Gohel, Suril; Milham, Michael P.; Biswal, Bharat B.; He, Yong

    2011-01-01

    Graph-based computational network analysis has proven a powerful tool to quantitatively characterize functional architectures of the brain. However, the test-retest (TRT) reliability of graph metrics of functional networks has not been systematically examined. Here, we investigated TRT reliability of topological metrics of functional brain networks derived from resting-state functional magnetic resonance imaging data. Specifically, we evaluated both short-term (5 months apart) TRT reliability for 12 global and 6 local nodal network metrics. We found that reliability of global network metrics was overall low, threshold-sensitive and dependent on several factors of scanning time interval (TI, long-term>short-term), network membership (NM, networks excluding negative correlations>networks including negative correlations) and network type (NT, binarized networks>weighted networks). The dependence was modulated by another factor of node definition (ND) strategy. The local nodal reliability exhibited large variability across nodal metrics and a spatially heterogeneous distribution. Nodal degree was the most reliable metric and varied the least across the factors above. Hub regions in association and limbic/paralimbic cortices showed moderate TRT reliability. Importantly, nodal reliability was robust to above-mentioned four factors. Simulation analysis revealed that global network metrics were extremely sensitive (but varying degrees) to noise in functional connectivity and weighted networks generated numerically more reliable results in compared with binarized networks. For nodal network metrics, they showed high resistance to noise in functional connectivity and no NT related differences were found in the resistance. These findings provide important implications on how to choose reliable analytical schemes and network metrics of interest. PMID:21818285

  20. Altered effective connectivity network of the basal ganglia in low-grade hepatic encephalopathy: a resting-state fMRI study with Granger causality analysis.

    Directory of Open Access Journals (Sweden)

    Rongfeng Qi

    Full Text Available BACKGROUND: The basal ganglia often show abnormal metabolism and intracranial hemodynamics in cirrhotic patients with hepatic encephalopathy (HE. Little is known about how the basal ganglia affect other brain system and is affected by other brain regions in HE. The purpose of this study was to investigate whether the effective connectivity network associated with the basal ganglia is disturbed in HE patients by using resting-state functional magnetic resonance imaging (rs-fMRI. METHODOLOGY/PRINCIPAL FINDINGS: Thirty five low-grade HE patients and thirty five age- and gender- matched healthy controls participated in the rs-fMRI scans. The effective connectivity networks associated with the globus pallidus, the primarily affected region within basal ganglia in HE, were characterized by using the Granger causality analysis and compared between HE patients and healthy controls. Pearson correlation analysis was performed between the abnormal effective connectivity and venous blood ammonia levels and neuropsychological performances of all HE patients. Compared with the healthy controls, patients with low-grade HE demonstrated mutually decreased influence between the globus pallidus and the anterior cingulate cortex (ACC, cuneus, bi-directionally increased influence between the globus pallidus and the precuneus, and either decreased or increased influence from and to the globus pallidus in many other frontal, temporal, parietal gyri, and cerebellum. Pearson correlation analyses revealed that the blood ammonia levels in HE patients negatively correlated with effective connectivity from the globus pallidus to ACC, and positively correlated with that from the globus pallidus to precuneus; and the number connectivity test scores in patients negatively correlated with the effective connectivity from the globus pallidus to ACC, and from superior frontal gyrus to globus pallidus. CONCLUSIONS/SIGNIFICANCE: Low-grade HE patients had disrupted effective

  1. The Ensembl REST API: Ensembl Data for Any Language.

    Science.gov (United States)

    Yates, Andrew; Beal, Kathryn; Keenan, Stephen; McLaren, William; Pignatelli, Miguel; Ritchie, Graham R S; Ruffier, Magali; Taylor, Kieron; Vullo, Alessandro; Flicek, Paul

    2015-01-01

    We present a Web service to access Ensembl data using Representational State Transfer (REST). The Ensembl REST server enables the easy retrieval of a wide range of Ensembl data by most programming languages, using standard formats such as JSON and FASTA while minimizing client work. We also introduce bindings to the popular Ensembl Variant Effect Predictor tool permitting large-scale programmatic variant analysis independent of any specific programming language. The Ensembl REST API can be accessed at http://rest.ensembl.org and source code is freely available under an Apache 2.0 license from http://github.com/Ensembl/ensembl-rest. © The Author 2014. Published by Oxford University Press.

  2. [Analysis of body composition and resting metabolic rate of 858 middle-aged and elderly people in urban area of Beijing].

    Science.gov (United States)

    Yu, D N; Xian, T Z; Wang, L J; Cheng, B; Sun, M X; Guo, L X

    2018-05-10

    Objective: To understand the overweight rate and obesity rate in middle-aged and elderly people in urban area of Beijing, and analyze the changes of body composition and resting metabolic rate with age. Methods: From November 2014 to December 2015, body composition measurement and resting metabolic rate detection were conducted among 858 people aged 51 to 99 years, including 760 men, 98 women, who received physical examination at Beijing Hospital. Results: The overweight rate was 51.4 % , and the obesity rate was 16.9 % . The overweight rate was 26.5 % and the obesity rate was 14.3 % in women, significantly lower than those in men (54.6 % and 17.2 % ) ( P area and resting metabolic rate in different age groups were different ( P area increased obviously ( P area increased significantly in age group 70- years ( P area of Beijing, and the rates were higher in men than in women. With the increase of age, the skeletal muscle volume, muscle index and resting metabolic rate gradually decreased, while the percentage of body fat and visceral fat area increased; Overweight and obese people had earlier changes in body composition and resting metabolic rate.

  3. Testing the non-locality of quantum theory in two-kaon systems

    Energy Technology Data Exchange (ETDEWEB)

    Eberhard, P.H. (California Univ., Berkeley (United States). Lawrence Berkeley Lab.)

    1993-06-07

    An idea for testing the non-local character of quantum theory in systems made of two neutral kaons is suggested. Such tests require detecting two long-lived or two short-lived neutral kaons in coincidence, when copper slabs are either interposed on or removed from their paths. They may be performed at an asymmetric [Phi][sup 0]-factory. They could answer some questions raised by the EPR paradox and Bell's inequalities. If such tests are performed and if predictions of quantum mechanics and standard theory of kaon regeneration are verified experimentally, all descriptions of the relevant phenomena in terms of local interactions will be ruled out in principle with the exception of very peculiar ones, which imply the existence of hidden variables, of different kinds of kaons corresponding to different values of the hidden variables, and, for some of these kaons, of regeneration probabilities enhanced by a factor of the order of 400 or more over the average. Of course, the experiment may also reveal a break down of quantum theory. (orig.)

  4. From Einstein's theorem to Bell's theorem: a history of quantum non-locality

    Science.gov (United States)

    Wiseman, H. M.

    2006-04-01

    In this Einstein Year of Physics it seems appropriate to look at an important aspect of Einstein's work that is often down-played: his contribution to the debate on the interpretation of quantum mechanics. Contrary to physics ‘folklore’, Bohr had no defence against Einstein's 1935 attack (the EPR paper) on the claimed completeness of orthodox quantum mechanics. I suggest that Einstein's argument, as stated most clearly in 1946, could justly be called Einstein's reality locality completeness theorem, since it proves that one of these three must be false. Einstein's instinct was that completeness of orthodox quantum mechanics was the falsehood, but he failed in his quest to find a more complete theory that respected reality and locality. Einstein's theorem, and possibly Einstein's failure, inspired John Bell in 1964 to prove his reality locality theorem. This strengthened Einstein's theorem (but showed the futility of his quest) by demonstrating that either reality or locality is a falsehood. This revealed the full non-locality of the quantum world for the first time.

  5. Self-organized criticality revisited: non-local transport by turbulent amplification

    DEFF Research Database (Denmark)

    Milovanov, Alexander V.; Rasmussen, Jens Juul

    2015-01-01

    We revise the applications of self-organized criticality (SOC) as a paradigmatic model for tokamak plasma turbulence. The work, presented here, is built around the idea that some systems do not develop a pure critical state associable with SOC, since their dynamical evolution involves as a compet......We revise the applications of self-organized criticality (SOC) as a paradigmatic model for tokamak plasma turbulence. The work, presented here, is built around the idea that some systems do not develop a pure critical state associable with SOC, since their dynamical evolution involves...... as a competing key factor an inverse cascade of the energy in reciprocal space. Then relaxation of slowly increasing stresses will give rise to intermittent bursts of transport in real space and outstanding transport events beyond the range of applicability of the 'conventional' SOC. Also, we are concerned...... with the causes and origins of non-local transport in magnetized plasma, and show that this type of transport occurs naturally in self-consistent strong turbulence via a complexity coupling to the inverse cascade. We expect these coupling phenomena to occur in the parameter range of strong nonlinearity and time...

  6. Spiking cortical model based non-local means method for despeckling multiframe optical coherence tomography data

    Science.gov (United States)

    Gu, Yameng; Zhang, Xuming

    2017-05-01

    Optical coherence tomography (OCT) images are severely degraded by speckle noise. Existing methods for despeckling multiframe OCT data cannot deliver sufficient speckle suppression while preserving image details well. To address this problem, the spiking cortical model (SCM) based non-local means (NLM) method has been proposed in this letter. In the proposed method, the considered frame and two neighboring frames are input into three SCMs to generate the temporal series of pulse outputs. The normalized moment of inertia (NMI) of the considered patches in the pulse outputs is extracted to represent the rotational and scaling invariant features of the corresponding patches in each frame. The pixel similarity is computed based on the Euclidean distance between the NMI features and used as the weight. Each pixel in the considered frame is restored by the weighted averaging of all pixels in the pre-defined search window in the three frames. Experiments on the real multiframe OCT data of the pig eye demonstrate the advantage of the proposed method over the frame averaging method, the multiscale sparsity based tomographic denoising method, the wavelet-based method and the traditional NLM method in terms of visual inspection and objective metrics such as signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), equivalent number of looks (ENL) and cross-correlation (XCOR).

  7. Non-local electron transport through normal and topological ladder-like atomic systems

    Science.gov (United States)

    Kurzyna, Marcin; Kwapiński, Tomasz

    2018-05-01

    We propose a locally protected ladder-like atomic system (nanoconductor) on a substrate that is insensitive to external perturbations. The system corresponds to coupled atomic chains fabricated on different surfaces. Electron transport properties of such conductors are studied theoretically using the model tight-binding Su-Schriffer-Hegger (SSH) Hamiltonian and Green's function formalism. We have found that the conductance of the system is almost insensitive to single adatoms and oscillates as a function of the side chain length with very large periods. Non-local character of the electron transport was observed also for topological SSH chains where nontrivial end states survive in the presence of disturbances as well as for different substrates. We have found that the careful inspection of the density of states or charge waves can provide the information about the atom energy levels and hopping amplitudes. Moreover, the ladder-like geometry allows one to distinguish between normal and topological zero-energy states. It is important that topological chains do not reveal Friedel oscillations which are observed in non-topological chains.

  8. Homotopic non-local regularized reconstruction from sparse positron emission tomography measurements

    International Nuclear Information System (INIS)

    Wong, Alexander; Liu, Chenyi; Wang, Xiao Yu; Fieguth, Paul; Bie, Hongxia

    2015-01-01

    Positron emission tomography scanners collect measurements of a patient’s in vivo radiotracer distribution. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on a biologically active molecule, and the tomograms must be reconstructed from projections. The reconstruction of tomograms from the acquired PET data is an inverse problem that requires regularization. The use of tightly packed discrete detector rings, although improves signal-to-noise ratio, are often associated with high costs of positron emission tomography systems. Thus a sparse reconstruction, which would be capable of overcoming the noise effect while allowing for a reduced number of detectors, would have a great deal to offer. In this study, we introduce and investigate the potential of a homotopic non-local regularization reconstruction framework for effectively reconstructing positron emission tomograms from such sparse measurements. Results obtained using the proposed approach are compared with traditional filtered back-projection as well as expectation maximization reconstruction with total variation regularization. A new reconstruction method was developed for the purpose of improving the quality of positron emission tomography reconstruction from sparse measurements. We illustrate that promising reconstruction performance can be achieved for the proposed approach even at low sampling fractions, which allows for the use of significantly fewer detectors and have the potential to reduce scanner costs

  9. Sex comparisons of non-local muscle fatigue in human elbow flexors and knee extensors

    Science.gov (United States)

    Ye, Xin; Beck, Travis W.; Wages, Nathan P.; Carr, Joshua C.

    2018-01-01

    Objectives: To examine non-local muscle fatigue (NLMF) in both contralateral homologous and non-related heterogonous muscles for both sexes. Methods: Ten men and nine women participated in this study. After the familiarization visit, subjects completed four separate randomly sequenced experimental visits, during which the fatiguing interventions (six sets of 30-second maximal isometric contractions) were performed on either their right elbow flexors or knee extensors. Before (Pre-) and after (Post-) the fatiguing interventions, the isometric strength and the corresponding surface electromyographic (EMG) amplitude were measured for the non-exercised left elbow flexors or knee extensors. Results: For the non-exercised elbow flexors, the isometric strength decreased for both sexes (sex combined mean±SE: Pre vs. Post=339.67±18.02 N vs. 314.41±16.37 N; pisometric knee extension strength for men (Pre vs. Post =845.02±66.26 N vs. 817.39±67.64 N; p=0.019), but not for women. Conclusions: The presence of NMLF can be affected by factors such as sex and muscle being tested. Women are less likely to demonstrate NLMF in lower body muscle groups. PMID:29504584

  10. Non-local transport in a tokamak plasma divertor with recycling

    International Nuclear Information System (INIS)

    Abou-Assaleh, Z.; Petravic, M.; Vesey, R.

    1993-01-01

    The plasma transport, particle and energy fluxes, near the diverter plate with high recycling has been modeled by using an electron kinetic code (Fokker-Planck International) in conjunction with a two-fluid ambipolar code. We include the effects of ionization and excitation of the hydrogen atoms. The electron energy distribution calculated from the kinetic code shows a large deviation from Maxwellian especially near the plate. This deviation from Maxwellian is due to the non-local transport of the suprathermal electrons from the SOL, and due also to the absorption of the fast electrons by the target plate. The heat flux near the plate is shown to be nonlocal, in that it is not determined uniquely by the local plasma parameters. Therefore the classical transport coefficients in the fluid model must be modified by including a nonlocal effect to produce the kinetic results. The kinetic calculation is compared with those of the fluid code with different values of the electron heat flux limiter factor (f). To reduce the computer load, the initial condition we used corresponds to the equilibrium solution already found with the fluid code with f=0.2. The fluid and Fokker-Planck codes are relaxed until all transients associated with electron dynamics have disappeared. In section 2, we present the kinetic code. The fluid code is presented in section 3. The boundary conditions used in these simulations are given in section 4. Finally the results and conclusion of these simulations are presented in section 5

  11. Measure solutions for non-local interaction PDEs with two species

    Energy Technology Data Exchange (ETDEWEB)

    Francesco, Marco Di [Department of Mathematical and Statistical Sciences, University of Bath, Claverton Down, Bath, BA2 7AY (United Kingdom); Fagioli, Simone [DISIM—Department of Information Engineering, Computer Science and Mathematics, University of L' Aquila, Via Vetoio 1 (Coppito) 67100 L' Aquila (AQ) (Italy)

    2013-10-01

    This paper presents a systematic existence and uniqueness theory of weak measure solutions for systems of non-local interaction PDEs with two species, which are the PDE counterpart of systems of deterministic interacting particles with two species. The main motivations behind those models arise in cell biology, pedestrian movements, and opinion formation. In case of symmetrizable systems (i.e. with cross-interaction potentials one multiple of the other), we provide a complete existence and uniqueness theory within (a suitable generalization of) the Wasserstein gradient flow theory in Ambrosio et al (2008 Gradient Flows in Metric Spaces and in the Space of Probability Measures (Lectures in Mathematics ETH Zürich) 2nd edn (Basel: Birkhäuser)) and Carrillo et al (2011 Duke Math. J. 156 229–71), which allows the consideration of interaction potentials with a discontinuous gradient at the origin. In the general case of non-symmetrizable systems, we provide an existence result for measure solutions which uses a semi-implicit version of the Jordan–Kinderlehrer–Otto (JKO) scheme (Jordan et al 1998 SIAM J. Math. Anal. 29 1–17), which holds in a reasonable non-smooth setting for the interaction potentials. Uniqueness in the non-symmetrizable case is proven for C{sup 2} potentials using a variant of the method of characteristics. (paper)

  12. Measure solutions for non-local interaction PDEs with two species

    International Nuclear Information System (INIS)

    Francesco, Marco Di; Fagioli, Simone

    2013-01-01

    This paper presents a systematic existence and uniqueness theory of weak measure solutions for systems of non-local interaction PDEs with two species, which are the PDE counterpart of systems of deterministic interacting particles with two species. The main motivations behind those models arise in cell biology, pedestrian movements, and opinion formation. In case of symmetrizable systems (i.e. with cross-interaction potentials one multiple of the other), we provide a complete existence and uniqueness theory within (a suitable generalization of) the Wasserstein gradient flow theory in Ambrosio et al (2008 Gradient Flows in Metric Spaces and in the Space of Probability Measures (Lectures in Mathematics ETH Zürich) 2nd edn (Basel: Birkhäuser)) and Carrillo et al (2011 Duke Math. J. 156 229–71), which allows the consideration of interaction potentials with a discontinuous gradient at the origin. In the general case of non-symmetrizable systems, we provide an existence result for measure solutions which uses a semi-implicit version of the Jordan–Kinderlehrer–Otto (JKO) scheme (Jordan et al 1998 SIAM J. Math. Anal. 29 1–17), which holds in a reasonable non-smooth setting for the interaction potentials. Uniqueness in the non-symmetrizable case is proven for C 2 potentials using a variant of the method of characteristics. (paper)

  13. Identification and functional characterization of HIV-associated neurocognitive disorders with large-scale Granger causality analysis on resting-state functional MRI

    Science.gov (United States)

    Chockanathan, Udaysankar; DSouza, Adora M.; Abidin, Anas Z.; Schifitto, Giovanni; Wismüller, Axel

    2018-02-01

    Resting-state functional MRI (rs-fMRI), coupled with advanced multivariate time-series analysis methods such as Granger causality, is a promising tool for the development of novel functional connectivity biomarkers of neurologic and psychiatric disease. Recently large-scale Granger causality (lsGC) has been proposed as an alternative to conventional Granger causality (cGC) that extends the scope of robust Granger causal analyses to high-dimensional systems such as the human brain. In this study, lsGC and cGC were comparatively evaluated on their ability to capture neurologic damage associated with HIV-associated neurocognitive disorders (HAND). Functional brain network models were constructed from rs-fMRI data collected from a cohort of HIV+ and HIV- subjects. Graph theoretic properties of the resulting networks were then used to train a support vector machine (SVM) model to predict clinically relevant parameters, such as HIV status and neuropsychometric (NP) scores. For the HIV+/- classification task, lsGC, which yielded a peak area under the receiver operating characteristic curve (AUC) of 0.83, significantly outperformed cGC, which yielded a peak AUC of 0.61, at all parameter settings tested. For the NP score regression task, lsGC, with a minimum mean squared error (MSE) of 0.75, significantly outperformed cGC, with a minimum MSE of 0.84 (p < 0.001, one-tailed paired t-test). These results show that, at optimal parameter settings, lsGC is better able to capture functional brain connectivity correlates of HAND than cGC. However, given the substantial variation in the performance of the two methods at different parameter settings, particularly for the regression task, improved parameter selection criteria are necessary and constitute an area for future research.

  14. Analysis of Amygdalar-Cortical Network Covariance During Pre- versus Post-menopausal Estrogen Levels: Potential Relevance to Resting State Networks, Mood, and Cognition

    Science.gov (United States)

    Ottowitz, William E.; Derro, David; Dougherty, Darin D.; Lindquist, Martin A.; Fischman, Alan J.; Hall, Janet E.

    2014-01-01

    Objectives 1.) Expand the scope of neuroendocrine applications of functional neuroimaging techniques. 2.) Compare the covariance of amygdalar activity with that of the rest of the brain during pre- and post-menopausal levels of estrogen (E2). Based on the distribution of cortical E2 receptors and the neocortical regions where E2 has been shown to preferentially accumulate, we predict that E2 infusion will increase covariance of amygdalar activity with that of the temporal and frontal cortices. Design This basic physiology study employed a within-subject design. All participants were post-menopausal women (n =7). Analysis of covariance between whole brain and amygdalar regional cerebral glucose consumption (CMRglc) was conducted in a voxel-wise manner by means of the basic regression option in SPM2 and was applied to FDG-PET scans acquired at baseline and after a 24 hour graded E2 infusion. Setting an academic medical center; Massachusetts General Hospital, Boston, Massachusetts. Results E2 levels (mean ± sem) were significantly greater at 24 hours (257.9 pg/mL ± 29.7) than at 0 hours (28.1 pg/mL ± 3.4). Right amygdalar CMRglc showed a significant covariance with activity of three different regions of the temporal cortex during E2 infusion, but none at baseline. In addition, right amygdalar CMRglc covaried with that of the right medial and superior frontal gyri only during E2 infusion. Conclusions In addition to suggesting changes in amygdalar-cortical network connectivity as a result of short-term E2 exposure, these analyses provide evidence that basic neuroendocrine research may benefit from further use of FDG-PET and other functional neuroimaging modalities for network level analyses. PMID:18766152

  15. Baricitinib in Patients with Rheumatoid Arthritis and an Inadequate Response to Conventional Disease-Modifying Antirheumatic Drugs in United States and Rest of World: A Subset Analysis.

    Science.gov (United States)

    Wells, Alvin F; Greenwald, Maria; Bradley, John D; Alam, Jahangir; Arora, Vipin; Kartman, Cynthia E

    2018-06-01

    This article evaluates the efficacy and safety of baricitinib 4 mg versus placebo in United States including Puerto Rico (US) and rest of the world (ROW) subpopulations using data pooled from RA-BEAM and RA-BUILD, which enrolled patients with moderate-to-severe adult-onset rheumatoid arthritis (RA). In RA-BEAM, patients with an inadequate response (IR) to methotrexate, at least one X-ray erosion, and high sensitivity C-reactive protein (hsCRP) ≥ 6 mg/L were randomized to placebo or orally administered baricitinib 4 mg daily or subcutaneously administered adalimumab 40 mg every other week. In RA-BUILD, patients with an IR to at least one conventional synthetic disease-modifying antirheumatic drug (csDMARD) and with hsCRP ≥ 3.6 mg/L were randomized to placebo or baricitinib 2 or 4 mg daily. Patients in both trials were biologic naive. In this post hoc analysis, data from both studies were pooled (714 baricitinib 4 mg-treated, 716 placebo-treated patients). Overall, 188 US and 1242 ROW patients were included. Subgroups differed in baseline characteristics including race, weight, age, time since RA diagnosis, current corticosteroid use, and previous csDMARD use. At weeks 12 and 24, baricitinib-treated patients had larger responses compared to placebo-treated patients for multiple efficacy outcomes: American College of Rheumatology 20/50/70 response, low disease activity, remission, Disease Activity Score 28-C-reactive protein, and Health Assessment Questionnaire-Disability Index. Overall, similar efficacy was observed in US and ROW subgroups with no notable safety differences between subgroups at weeks 12 or 24. Baricitinib 4 mg was efficacious compared to placebo in US and ROW subpopulations. Safety was similar between subgroups. Eli Lilly & Company and Incyte Corporation. ClinicalTrials.gov identifiers, NCT01721057; NCT01710358.

  16. Embodied carbon dioxide emission at supra-national scale: A coalition analysis for G7, BRIC, and the rest of the world

    International Nuclear Information System (INIS)

    Chen, Z.M.; Chen, G.Q.

    2011-01-01

    Presented in this study is an empirical analysis of embodied carbon dioxide emissions induced by fossil fuel combustion for the world divided into three supra-national coalitions, i.e., G7, BRIC, and the rest of the world (ROW), via the application of a multi-region input-output modeling for 2004. Embodied emission intensities for the three coalitions are calculated and compared, with market exchange rate and purchase power parity separately used to investigate the difference between nominal and real production efficiencies. Emissions embodied in different economic activities such as production, consumption, import, and export are calculated and analyzed accordingly, and remarkable carbon trade imbalances associated with G7 (surplus of 1.53 billion tons, or 36% its traded emissions) and BRIC (deficit of 1.37 billion tons, or 51% its traded emissions) and approximate balance with ROW (deficit of 0.16 billion tons, or 3% its traded emissions) are concretely revealed. Carbon leakages associated with industry transfer and international trades are illustrated in terms of impacts on global climate policies. The last but not least, per capita consumption based emissions for G7, BRIC, and ROW are determined as 12.95, 1.53, and 2.22 tons, respectively, and flexible abatement policies as well as equity on per capita entitlement are discussed. - Research highlights: → We compare the embodied CO 2 emissions in 2004 for G7, BRIC, and ROW. → Emissions embodied in production, consumption, import, and export are investigated. → Considerable CO 2 trade surplus and deficit are obtained by G7 and BRIC, respectively. → Per head embodied emissions are 13, 1.5, and 2.2 tons for G7, BRIC, and ROW, respectively.

  17. Probing the transition from non-localization to localization by K-shell photoemission from isotope-substituted N2

    International Nuclear Information System (INIS)

    Rolles, Daniel; Braune, Markus; Cvejanovic, Slobodan; Gessner, Oliver; Hentges, Rainer; Korica, Sanja; Langer, Burkhard; Lischke, Toralf; Pruemper, Georg; Reinkoester, Axel; Viefhaus, Jens; Zimmermann, Bjoern; McKoy, Vince; Becker, Uwe

    2006-01-01

    In homonuclear diatomic molecules such as N 2 , the inversion symmetry of the system causes non-local, coherent behavior of the otherwise localized core holes. The non-locality of the electron emission and the remaining core hole changes in a continuous way into partially localized behaviour if a gradual breakdown of the inversion symmetry is induced by isotope substitution. This is reflected by a loss of interference and a parity mixing of the outgoing photoelectron waves. Our results represent the first experimentally observed isotope effect on the electronic structure of a diatomic molecule

  18. The Amsterdam Resting-State Questionnaire reveals multiple phenotypes of resting-state cognition

    Directory of Open Access Journals (Sweden)

    B. Alexander eDiaz

    2013-08-01

    Full Text Available Resting-state neuroimaging is a dominant paradigm for studying brain function in health and disease. It is attractive for clinical research because of its simplicity for patients, straightforward standardization, and sensitivity to brain disorders. Importantly, non-sensory experiences like mind wandering may arise from ongoing brain activity. However, little is known about the link between ongoing brain activity and cognition, as phenotypes of resting-state cognition—and tools to quantify them—have been lacking. To facilitate rapid and structured measurements of resting-state cognition we developed a 50-item self-report survey, the Amsterdam Resting-State Questionnaire (ARSQ. Based on ARSQ data from 813 participants assessed after five minutes eyes-closed rest in their home, we identified seven dimensions of resting-state cognition using factor analysis: Discontinuity of Mind, Theory of Mind, Self, Planning, Sleepiness, Comfort, and Somatic Awareness. Further, we showed that the structure of cognition was similar during resting-state fMRI and EEG, and that the test-retest correlations were remarkably high for all dimensions. To explore whether inter-individual variation of resting-state cognition is related to health status, we correlated ARSQ-derived factor scores with psychometric scales measuring depression, anxiety, and sleep quality. Mental health correlated positively with Comfort and negatively with Discontinuity of Mind. Finally, we show that sleepiness may partially explain a resting-state EEG profile previously associated with Alzheimer’s disease. These findings indicate that the ARSQ readily provides information about cognitive phenotypes and that it is a promising tool for research on the neural correlates of resting-state cognition in health and disease.

  19. The Amsterdam Resting-State Questionnaire reveals multiple phenotypes of resting-state cognition

    Science.gov (United States)

    Diaz, B. Alexander; Van Der Sluis, Sophie; Moens, Sarah; Benjamins, Jeroen S.; Migliorati, Filippo; Stoffers, Diederick; Den Braber, Anouk; Poil, Simon-Shlomo; Hardstone, Richard; Van't Ent, Dennis; Boomsma, Dorret I.; De Geus, Eco; Mansvelder, Huibert D.; Van Someren, Eus J. W.; Linkenkaer-Hansen, Klaus

    2013-01-01

    Resting-state neuroimaging is a dominant paradigm for studying brain function in health and disease. It is attractive for clinical research because of its simplicity for patients, straightforward standardization, and sensitivity to brain disorders. Importantly, non-sensory experiences like mind wandering may arise from ongoing brain activity. However, little is known about the link between ongoing brain activity and cognition, as phenotypes of resting-state cognition—and tools to quantify them—have been lacking. To facilitate rapid and structured measurements of resting-state cognition we developed a 50-item self-report survey, the Amsterdam Resting-State Questionnaire (ARSQ). Based on ARSQ data from 813 participants assessed after 5 min eyes-closed rest in their home, we identified seven dimensions of resting-state cognition using factor analysis: Discontinuity of Mind, Theory of Mind, Self, Planning, Sleepiness, Comfort, and Somatic Awareness. Further, we showed that the structure of cognition was similar during resting-state fMRI and EEG, and that the test-retest correlations were remarkably high for all dimensions. To explore whether inter-individual variation of resting-state cognition is related to health status, we correlated ARSQ-derived factor scores with psychometric scales measuring depression, anxiety, and sleep quality. Mental health correlated positively with Comfort and negatively with Discontinuity of Mind. Finally, we show that sleepiness may partially explain a resting-state EEG profile previously associated with Alzheimer's disease. These findings indicate that the ARSQ readily provides information about cognitive phenotypes and that it is a promising tool for research on the neural correlates of resting-state cognition in health and disease. PMID:23964225

  20. Dipoles at rest

    International Nuclear Information System (INIS)

    Griffiths, D.J.

    1992-01-01

    In a world populated by magnetic monopoles (as well as ordinary electric charges), there are two kinds of electric dipoles: those due to separated electric charges, and those due to current loops of magnetic charge. Similarly, there are two kinds of magnetic dipoles: those due to separated magnetic monopoles, and those due to electric current loops. This paper derives the potentials and fields of each of the four dipole species, and calculates the force, torque, energy, momentum, and angular momentum of each type, when placed (at rest) in a static external field (which may itself be produced by electric charges and currents, magnetic charges and currents, or all of these). Some implications and applications of the various results are discussed

  1. Altered pattern of spontaneous brain activity in the patients with end-stage renal disease: a resting-state functional MRI study with regional homogeneity analysis.

    Directory of Open Access Journals (Sweden)

    Xue Liang

    Full Text Available PURPOSE: To investigate the pattern of spontaneous neural activity in patients with end-stage renal disease (ESRD with and without neurocognitive dysfunction using resting-state functional magnetic resonance imaging (rs-fMRI with a regional homogeneity (ReHo algorithm. MATERIALS AND METHODS: rs-fMRI data were acquired in 36 ESRD patients (minimal nephro-encephalopathy [MNE], n = 19, 13 male, 37±12.07 years; non-nephro-encephalopathy [non-NE], n = 17, 11 male, 38±12.13 years and 20 healthy controls (13 male, 7 female, 36±10.27 years. Neuropsychological (number connection test type A [NCT-A], digit symbol test [DST] and laboratory tests were performed in all patients. The Kendall's coefficient of concordance (KCC was used to measure the regional homogeneity for each subject. The regional homogeneity maps were compared using ANOVA tests among MNE, non-NE, and healthy control groups and post hoc t -tests between each pair in a voxel-wise way. A multiple regression analysis was performed to evaluate the relationships between ReHo index and NCT-A, DST scores, serum creatinine and urea levels, disease and dialysis duration. RESULTS: Compared with healthy controls, both MNE and non-NE patients showed decreased ReHo in the multiple areas of bilateral frontal, parietal and temporal lobes. Compared with the non-NE, MNE patients showed decreased ReHo in the right inferior parietal lobe (IPL, medial frontal cortex (MFC and left precuneus (PCu. The NCT-A scores and serum urea levels of ESRD patients negatively correlated with ReHo values in the frontal and parietal lobes, while DST scores positively correlated with ReHo values in the bilateral PCC/precuneus, MFC and inferior parietal lobe (IPL (all P0.05, AlphaSim corrected. CONCLUSION: Diffused decreased ReHo values were found in both MNE and non-NE patients. The progressively decreased ReHo in the default mode network (DMN, frontal and parietal lobes might be trait-related in MNE. The Re

  2. Numerical study on non-locally reacting behavior of nacelle liners incorporating drainage slots

    Science.gov (United States)

    Chen, Chao; Li, Xiaodong; Thiele, Frank

    2018-06-01

    For acoustic liners used in current commercial nacelles, in order to prevent any liquid accumulating in the resonators, drainage slots are incorporated on the partition walls between closely packed cavities. Recently, an experimental study conducted by Busse-Gerstengarbe et al. shown that the cell interaction introduced by drainage slots causes an additional dissipation peak which increases with the size of the slot. However, the variation of damping process due to drainage slots is still not fully understood. Therefore, a numerical study based on computational aeroacoustic methods is carried out to investigate the mechanism of the changed attenuation characteristics due to drainage slots in presence of grazing incident sound waves with low or high intensities. Different slot configurations are designed based on the generic non-locally reacting liner model adopted in the experimental investigation. Both 2-D and 3-D numerical simulations of only slit resonators are carried out. Numerical results indicate that the extra peak is a result of a resonance excited in the second cavity at specific frequency. Under high sound pressure level incoming waves, the basic characteristics of the acoustic performance remain. However, vortex shedding transpires at the resonances around both the slits and the drainage slot. Vorticity contours show that the connection of two coupled cavities decreases the strength of vortex shedding around the basic Helmholtz resonance due to a higher energy reflection. Meanwhile, the cell interaction significantly increases the vorticity magnitude near the extra resonant frequency. Finally, a semi-empirical model is derived to predict the extra attenuation peak frequency.

  3. Local and non-local deficits in amblyopia: acuity and spatial interactions.

    Science.gov (United States)

    Bonneh, Yoram S; Sagi, Dov; Polat, Uri

    2004-12-01

    Amblyopic vision is thought to be limited by abnormal long-range spatial interactions, but their exact mode of action and relationship to the main amblyopic deficit in visual acuity is largely unknown. We studied this relationship in a group (N=59) of anisometropic (N=21) and strabismic (or combined, N=38) subjects, using (1) a single and multi-pattern (crowded) computerized static Tumbling-E test with scaled spacing of two pattern widths (TeVA), in addition to an optotype (ETDRS chart) acuity test (VA) and (2) contrast detection of Gabor patches with lateral flankers (lateral masking) along the horizontal and vertical axes as well as in collinear and parallel configurations. By correlating the different measures of visual acuity and contrast suppression, we found that (1) the VA of the strabismic subjects could be decomposed into two uncorrelated components measured in TeVA: acuity for isolated patterns and acuity reduction due to flanking patterns. The latter comprised over 60% of the VA magnitude, on the average and accounted for over 50% of its variance. In contrast, a slight reduction in acuity was found in the anisometropic subjects, and the acuity for a single pattern could account for 70% of the VA variance. (2) The lateral suppression (contrast threshold elevation) in a parallel configuration along the horizontal axis was correlated with the VA (R2=0.7), as well as with the crowding effect (TeVA elevation, R2=0.5) for the strabismic group. Some correlation with the VA was also found for the collinear configuration in the anisometropic group, but less suppression and no correlation were found for all the vertical configurations in all the groups. The results indicate the existence of a specific non-local component of the strabismic deficit, in addition to the local acuity deficit in all amblyopia types. This deficit might reflect long-range lateral inhibition, or alternatively, an inaccurate and scattered top-down attentional selection mechanism.

  4. Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation

    NARCIS (Netherlands)

    Heida, Tjitske; Wentink, E.C.; Marani, Enrico

    2013-01-01

    Background: Observation of the signals recorded from the extremities of Parkinson’s disease patients showing rest and/or action tremor reveal a distinct high power resonance peak in the frequency band corresponding to tremor. The aim of the study was to investigate, using quantitative measures, how

  5. Anomalous van der Waals-Casimir interactions on graphene: A concerted effect of temperature, retardation, and non-locality

    Science.gov (United States)

    Ambrosetti, Alberto; Silvestrelli, Pier Luigi

    2018-04-01

    Dispersion forces play a major role in graphene, largely influencing adhesion of adsorbate moieties and stabilization of functional multilayered structures. However, the reliable prediction of dispersion interactions on graphene up to the relevant ˜10 nm scale is an extremely challenging task: in fact, electromagnetic retardation effects and the highly non-local character of π electrons can imply sizeable qualitative variations of the interaction with respect to known pairwise approaches. Here we address both issues, determining the finite-temperature van der Waals (vdW)-Casimir interaction for point-like and extended adsorbates on graphene, explicitly accounting for the non-local dielectric permittivity. We find that temperature, retardation, and non-locality play a crucial role in determining the actual vdW scaling laws and the stability of both atomic and larger molecular adsorbates. Our results highlight the importance of these effects for a proper description of systems of current high interest, such as graphene interacting with biomolecules, and self-assembly of complex nanoscale structures. Due to the generality of our approach and the observed non-locality of other 2D materials, our results suggest non-trivial vdW interactions from hexagonal mono-layered materials from group 14 of the periodic table, to transition metal dichalcogenides.

  6. Solvability conditions for non-local boundary value problems for two-dimensional half-linear differential systems

    Czech Academy of Sciences Publication Activity Database

    Kiguradze, I.; Šremr, Jiří

    2011-01-01

    Roč. 74, č. 17 (2011), s. 6537-6552 ISSN 0362-546X Institutional research plan: CEZ:AV0Z10190503 Keywords : half-linear differential system * non-local boundary value problem * solvability Subject RIV: BA - General Mathematics Impact factor: 1.536, year: 2011 http://www.sciencedirect.com/science/article/pii/S0362546X11004573

  7. Once an Outsider, Always an Outsider? The Accessibility of the Dutch Rural Housing Market among Locals and Non-Locals

    Science.gov (United States)

    de Groot, Carola; Daalhuizen, Femke B. C.; van Dam, Frank; Mulder, Clara H.

    2012-01-01

    One of the most pressing questions in the rural gentrification literature is whether rural residents face difficulties in finding a home within their locality due to the influx of more wealthy newcomers. In this paper, we investigate the extent to which intended local movers and intended non-local movers have realised their rural residential…

  8. Age-Dependent Changes in Resting Energy Expenditure (REE): Insights from Detailed Body Composition Analysis in Normal and Overweight Healthy Caucasians.

    Science.gov (United States)

    Geisler, Corinna; Braun, Wiebke; Pourhassan, Maryam; Schweitzer, Lisa; Glüer, Claus-Christian; Bosy-Westphal, Anja; Müller, Manfred J

    2016-06-01

    Age-related changes in organ and tissue masses may add to changes in the relationship between resting energy expenditure (REE) and fat free mass (FFM) in normal and overweight healthy Caucasians. Secondary analysis using cross-sectional data of 714 healthy normal and overweight Caucasian subjects (age 18-83 years) with comprehensive information on FFM, organ and tissue masses (as assessed by magnetic resonance imaging (MRI)), body density (as assessed by Air Displacement Plethysmography (ADP)) and hydration (as assessed by deuterium dilution (D₂O)) and REE (as assessed by indirect calorimetry). High metabolic rate organs (HMR) summarized brain, heart, liver and kidney masses. Ratios of HMR organs and muscle mass (MM) in relation to FFM were considered. REE was calculated (REEc) using organ and tissue masses times their specific metabolic rates. REE, FFM, specific metabolic rates, the REE-FFM relationship, HOMA, CRP, and thyroid hormone levels change with age. The age-related decrease in FFM explained 59.7% of decreases in REE. Mean residuals of the REE-FFM association were positive in young adults but became negative in older subjects. When compared to young adults, proportions of MM to FFM decreased with age, whereas contributions of liver and heart did not differ between age groups. HOMA, TSH and inflammation (plasma CRP-levels) explained 4.2%, 2.0% and 1.4% of the variance in the REE-FFM residuals, but age and plasma T3-levels had no effects. HMR to FFM and MM to FFM ratios together added 11.8% on to the variance of REE-FFM residuals. Differences between REE and REEc increased with age, suggesting age-related changes in specific metabolic rates of organs and tissues. This bias was partly explained by plasmaT3-levels. Age-related changes in REE are explained by (i) decreases in fat free mass; (ii) a decrease in the contributions of organ and muscle masses to FFM; and (iii) decreases in specific organ and tissue metabolic rates. Age-dependent changes in the REE

  9. Horizons and non-local time evolution of quantum mechanical systems

    International Nuclear Information System (INIS)

    Casadio, Roberto

    2015-01-01

    According to general relativity, trapping surfaces and horizons are classical causal structures that arise in systems with sharply defined energy and corresponding gravitational radius. The latter concept can be extended to a quantum mechanical matter state simply by means of the spectral decomposition, which allows one to define an associated ''horizon wave-function''. Since this auxiliary wave-function contains crucial information about the causal structure of space-time, a new proposal is formulated for the time evolution of quantum systems in order to account for the fundamental classical property that outer observers cannot receive signals from inside a horizon. The simple case of a massive free particle at rest is used throughout the paper as a toy model to illustrate the main ideas. (orig.)

  10. New insights on emergence from the perspective of weak values and dynamical non-locality

    Science.gov (United States)

    Tollaksen, Jeff

    2014-04-01

    In this article, we will examine new fundamental aspects of "emergence" and "information" using novel approaches to quantum mechanics which originated from the group around Aharonov. The two-state vector formalism provides a complete description of pre- and post-selected quantum systems and has uncovered a host of new quantum phenomena which were previously hidden. The most important feature is that any weak coupling to a pre- and post-selected system is effectively a coupling to a "weak value" which is given by a simple expression depending on the two-state vector. In particular, weak values, are the outcomes of so called "weak measurements" which have recently become a very powerful tool for ultra-sensitive measurements. Using weak values, we will show how to separate a particle from its properties, not unlike the Cheshire cat story: "Well! I've often seen a cat without a grin," thought Alice; "but a grin without a cat! It's the most curious thing I ever saw in all my life!" Next, we address the question whether the physics on different scales "emerges" from quantum mechanics or whether the laws of physics at those scales are fundamental. We show that the classical limit of quantum mechanics is a far more complicated issue; it is in fact dramatically more involved and it requires a complete revision of all our intuitions. The revised intuitions can then serve as a guide to finding novel quantum effects. Next we show that novel experimental aspects of contextuality can be demonstrated with weak measurements and these suggest new restrictions on hidden variable approaches. Next we emphasize that the most important implication of the Aharonov-Bohm effect is the existence of non-local interactions which do not violate causality. Finally, we review some generalizations of quantum mechanics and their implications for "emergence" and "information." First, we review an alternative approach to quantum evolution in which each moment of time is viewed as a new "universe

  11. Measurements and non-local thermodynamic equilibrium modeling of mid-Z plasma emission

    International Nuclear Information System (INIS)

    Jacquet, L.; Primout, M.; Kaiser, P.; Clouët, J. F.; Girard, F.; Villette, B.; Reverdin, C.; Oudot, G.

    2015-01-01

    The x-ray yields from laser-irradiated thin foils of iron, copper, zinc, and germanium have been measured in the soft and multi-keV x-ray ranges at the OMEGA laser at the Laboratory for Laser Energetics. The incident laser power had a pre-pulse to enhance the x-ray emission of a 1 ns flat-top main pulse. The experimental results have been compared with post-shot simulations performed with the two-dimensional radiation-hydrodynamics code FCI2. A new non-local thermodynamic equilibrium model, NOO-RAD, have been incorporated into FCI2. In this approach, the plasma ionization state is in-line calculated by the atomic physics NOHEL package. In the soft x-ray bands, both simulations using RADIOM [M. Busquet, Phys. Fluids B 5, 4191 (1993)] and NOO-RAD clearly over-predict the powers and energies measured by a broad-band spectrometer. In one case (the iron foil), the discrepancy between the measured and simulated x-ray output is nevertheless significantly reduced when NOO-RAD is used in the simulations. In the multi-keV x-ray bands, the simulations display a strong sensitivity to the coupling between the electron thermal conductivity and the NLTE models, and for some particular combinations of these, provide a close match to the measured emission. The comparison between the measured and simulated H-like to He-like line-intensity ratios deduced from high-resolution spectra indicates higher experimental electron temperatures were achieved, compared to the simulated ones. Measurements of the plasma conditions have been achieved using the Thomson-scattering diagnostic. The electron temperatures are found to range from 3 to 5 keV at the end of the laser pulse and are greater than predicted by the simulations. The measured flow velocities are in reasonable agreement with the calculated ones. This last finding gives us confidence in our numerical predictions for the plasma parameters, which are over that time mainly determined by hydrodynamics, such as the mass densities and

  12. Measurements and non-local thermodynamic equilibrium modeling of mid-Z plasma emission

    Science.gov (United States)

    Jacquet, L.; Primout, M.; Kaiser, P.; Clouët, J. F.; Girard, F.; Villette, B.; Reverdin, C.; Oudot, G.

    2015-12-01

    The x-ray yields from laser-irradiated thin foils of iron, copper, zinc, and germanium have been measured in the soft and multi-keV x-ray ranges at the OMEGA laser at the Laboratory for Laser Energetics. The incident laser power had a pre-pulse to enhance the x-ray emission of a 1 ns flat-top main pulse. The experimental results have been compared with post-shot simulations performed with the two-dimensional radiation-hydrodynamics code FCI2. A new non-local thermodynamic equilibrium model, NOO-RAD, have been incorporated into FCI2. In this approach, the plasma ionization state is in-line calculated by the atomic physics NOHEL package. In the soft x-ray bands, both simulations using RADIOM [M. Busquet, Phys. Fluids B 5, 4191 (1993)] and NOO-RAD clearly over-predict the powers and energies measured by a broad-band spectrometer. In one case (the iron foil), the discrepancy between the measured and simulated x-ray output is nevertheless significantly reduced when NOO-RAD is used in the simulations. In the multi-keV x-ray bands, the simulations display a strong sensitivity to the coupling between the electron thermal conductivity and the NLTE models, and for some particular combinations of these, provide a close match to the measured emission. The comparison between the measured and simulated H-like to He-like line-intensity ratios deduced from high-resolution spectra indicates higher experimental electron temperatures were achieved, compared to the simulated ones. Measurements of the plasma conditions have been achieved using the Thomson-scattering diagnostic. The electron temperatures are found to range from 3 to 5 keV at the end of the laser pulse and are greater than predicted by the simulations. The measured flow velocities are in reasonable agreement with the calculated ones. This last finding gives us confidence in our numerical predictions for the plasma parameters, which are over that time mainly determined by hydrodynamics, such as the mass densities and the

  13. Measurements and non-local thermodynamic equilibrium modeling of mid-Z plasma emission

    Energy Technology Data Exchange (ETDEWEB)

    Jacquet, L., E-mail: laurent.jacquet@cea.fr; Primout, M.; Kaiser, P.; Clouët, J. F.; Girard, F.; Villette, B.; Reverdin, C.; Oudot, G. [CEA, DAM, DIF, F-91297 Arpajon (France)

    2015-12-15

    The x-ray yields from laser-irradiated thin foils of iron, copper, zinc, and germanium have been measured in the soft and multi-keV x-ray ranges at the OMEGA laser at the Laboratory for Laser Energetics. The incident laser power had a pre-pulse to enhance the x-ray emission of a 1 ns flat-top main pulse. The experimental results have been compared with post-shot simulations performed with the two-dimensional radiation-hydrodynamics code FCI2. A new non-local thermodynamic equilibrium model, NOO-RAD, have been incorporated into FCI2. In this approach, the plasma ionization state is in-line calculated by the atomic physics NOHEL package. In the soft x-ray bands, both simulations using RADIOM [M. Busquet, Phys. Fluids B 5, 4191 (1993)] and NOO-RAD clearly over-predict the powers and energies measured by a broad-band spectrometer. In one case (the iron foil), the discrepancy between the measured and simulated x-ray output is nevertheless significantly reduced when NOO-RAD is used in the simulations. In the multi-keV x-ray bands, the simulations display a strong sensitivity to the coupling between the electron thermal conductivity and the NLTE models, and for some particular combinations of these, provide a close match to the measured emission. The comparison between the measured and simulated H-like to He-like line-intensity ratios deduced from high-resolution spectra indicates higher experimental electron temperatures were achieved, compared to the simulated ones. Measurements of the plasma conditions have been achieved using the Thomson-scattering diagnostic. The electron temperatures are found to range from 3 to 5 keV at the end of the laser pulse and are greater than predicted by the simulations. The measured flow velocities are in reasonable agreement with the calculated ones. This last finding gives us confidence in our numerical predictions for the plasma parameters, which are over that time mainly determined by hydrodynamics, such as the mass densities and

  14. New insights on emergence from the perspective of weak values and dynamical non-locality

    International Nuclear Information System (INIS)

    Tollaksen, Jeff

    2014-01-01

    In this article, we will examine new fundamental aspects of 'emergence' and 'information' using novel approaches to quantum mechanics which originated from the group around Aharonov. The two-state vector formalism provides a complete description of pre- and post-selected quantum systems and has uncovered a host of new quantum phenomena which were previously hidden. The most important feature is that any weak coupling to a pre- and post-selected system is effectively a coupling to a 'weak value' which is given by a simple expression depending on the two-state vector. In particular, weak values, are the outcomes of so called 'weak measurements' which have recently become a very powerful tool for ultra-sensitive measurements. Using weak values, we will show how to separate a particle from its properties, not unlike the Cheshire cat story: 'Well! I've often seen a cat without a grin', thought Alice; 'but a grin without a cat! It's the most curious thing I ever saw in all my life!' Next, we address the question whether the physics on different scales 'emerges' from quantum mechanics or whether the laws of physics at those scales are fundamental. We show that the classical limit of quantum mechanics is a far more complicated issue; it is in fact dramatically more involved and it requires a complete revision of all our intuitions. The revised intuitions can then serve as a guide to finding novel quantum effects. Next we show that novel experimental aspects of contextuality can be demonstrated with weak measurements and these suggest new restrictions on hidden variable approaches. Next we emphasize that the most important implication of the Aharonov-Bohm effect is the existence of non-local interactions which do not violate causality. Finally, we review some generalizations of quantum mechanics and their implications for 'emergence' and 'information'. First, we review an

  15. DIRAC RESTful API

    International Nuclear Information System (INIS)

    Casajus Ramo, A; Graciani Diaz, R; Tsaregorodtsev, A

    2012-01-01

    The DIRAC framework for distributed computing has been designed as a flexible and modular solution that can be adapted to the requirements of any community. Users interact with DIRAC via command line, using the web portal or accessing resources via the DIRAC python API. The current DIRAC API requires users to use a python version valid for DIRAC. Some communities have developed their own software solutions for handling their specific workload, and would like to use DIRAC as their back-end to access distributed computing resources easily. Many of these solutions are not coded in python or depend on a specific python version. To solve this gap DIRAC provides a new language agnostic API that any software solution can use. This new API has been designed following the RESTful principles. Any language with libraries to issue standard HTTP queries may use it. GSI proxies can still be used to authenticate against the API services. However GSI proxies are not a widely adopted standard. The new DIRAC API also allows clients to use OAuth for delegating the user credentials to a third party solution. These delegated credentials allow the third party software to query to DIRAC on behalf of the users. This new API will further expand the possibilities communities have to integrate DIRAC into their distributed computing models.

  16. Resting-state FMRI confounds and cleanup

    Science.gov (United States)

    Murphy, Kevin; Birn, Rasmus M.; Bandettini, Peter A.

    2013-01-01

    The goal of resting-state functional magnetic resonance imaging (FMRI) is to investigate the brain’s functional connections by using the temporal similarity between blood oxygenation level dependent (BOLD) signals in different regions of the brain “at rest” as an indicator of synchronous neural activity. Since this measure relies on the temporal correlation of FMRI signal changes between different parts of the brain, any non-neural activity-related process that affects the signals will influence the measure of functional connectivity, yielding spurious results. To understand the sources of these resting-state FMRI confounds, this article describes the origins of the BOLD signal in terms of MR physics and cerebral physiology. Potential confounds arising from motion, cardiac and respiratory cycles, arterial CO2 concentration, blood pressure/cerebral autoregulation, and vasomotion are discussed. Two classes of techniques to remove confounds from resting-state BOLD time series are reviewed: 1) those utilising external recordings of physiology and 2) data-based cleanup methods that only use the resting-state FMRI data itself. Further methods that remove noise from functional connectivity measures at a group level are also discussed. For successful interpretation of resting-state FMRI comparisons and results, noise cleanup is an often over-looked but essential step in the analysis pipeline. PMID:23571418

  17. Analysis of Altered Baseline Brain Activity in Drug-Naive Adult Patients with Social Anxiety Disorder Using Resting-State Functional MRI

    OpenAIRE

    Qiu, Changjian; Feng, Yuan; Meng, Yajing; Liao, Wei; Huang, Xiaoqi; Lui, Su; Zhu, Chunyan; Chen, Huafu; Gong, Qiyong; Zhang, Wei

    2015-01-01

    Objective We hypothesize that the amplitude of low-frequency fluctuations (ALFF) is involved in the altered regional baseline brain function in social anxiety disorder (SAD). The aim of the study was to analyze the altered baseline brain activity in drug-naive adult patients with SAD. Methods We investigated spontaneous and baseline brain activities by obtaining the resting-state functional magnetic resonance imaging data of 20 drug-na?ve adult SAD patients and 19 healthy controls. Voxels wer...

  18. Ultrastructural changes in the glial cells at neuromuscular synapses of Locusta migratoria occurring after nerve stimulation and subsequent rest: a morphometric analysis.

    Science.gov (United States)

    Reinecke, M

    1979-10-01

    The glial processes ensheathing the motor nerve terminals on the retractor unguis muscle of Locusta migratoria are described. Ultrastructural changes observed after electrical nerve stimulation (20 Hz, 7 min) without or with subsequent rest (2 min, 1 h) are analysed morphometrically. Immediately after stimulation both the average terminal circumference (+ 23%) and its proportion covered by glial processes (+ 16%) are significantly increased. The mean number of Schwann cell processes per micron of terminal circumference (without stimulation: 0.86 +/- 0.04) is also affected: Immediately after stimulation it is increased by about 15% and after 2 min of rest even by 36%. The periaxonal cleft (without stimulation: 16.5 nm +/- 0.36) becomes wider immediately after stimulation by about 19%, an effect which is almost reversed after 1 h of rest. It is suggested that these changes are a consequence of the enlargement of the nerve terminal's surface upon massive exocytotic activity and that they are possibly mediated by mechanical attachment between glial and terminal plasma membranes.

  19. Physiology Of Prolonged Bed Rest

    Science.gov (United States)

    Greenleaf, John E.

    1991-01-01

    Report describes physiological effects of prolonged bed rest. Rest for periods of 24 hours or longer deconditions body to some extent; healing proceeds simultaneously with deconditioning. Report provides details on shifts in fluid electrolytes and loss of lean body mass, which comprises everything in body besides fat - that is, water, muscle, and bone. Based on published research.

  20. Functional alterations of fronto-limbic circuit and default mode network systems in first-episode, drug-naïve patients with major depressive disorder: A meta-analysis of resting-state fMRI data.

    Science.gov (United States)

    Zhong, Xue; Pu, Weidan; Yao, Shuqiao

    2016-12-01

    The neurobiological mechanisms of depression are increasingly being explored through resting-state brain imaging studies. However, resting-state fMRI findings have varied, perhaps because of differences between study populations, which included the disorder course and medication use. The aim of our study was to integrate studies of resting-state fMRI and explore the alterations of abnormal brain activity in first-episode, drug-naïve patients with major depressive disorder. Relevant imaging reports in English were searched, retrieved, selected and subjected to analysis by activation likelihood estimation, a coordinate-based meta-analysis technique (final sample, 31 studies). Coordinates extracted from the original reports were assigned to two categories based on effect directionality. Compared with healthy controls, the first-episode, medication-naïve major depressive disorder patients showed decreased brain activity in the dorsolateral prefrontal cortex, superior temporal gyrus, posterior precuneus, and posterior cingulate, as well as in visual areas within the occipital lobe, lingual gyrus, and fusiform gyrus, and increased activity in the putamen and anterior precuneus. Not every study that has reported relevant data met the inclusion criteria. Resting-state functional alterations were located mainly in the fronto-limbic system, including the dorsolateral prefrontal cortex and putamen, and in the default mode network, namely the precuneus and superior/middle temporal gyrus. Abnormal functional alterations of the fronto-limbic circuit and default mode network may be characteristic of first-episode, drug-naïve major depressive disorder patients. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. One-loop effective action for non-local modified Gauss-Bonnet gravity in de Sitter space

    Energy Technology Data Exchange (ETDEWEB)

    Cognola, Guido; Zerbini, Sergio [Universita di Trento (Italy); Istituto Nazionale di Fisica Nucleare Gruppo Collegato di Trento, Dipartimento di Fisica, Trento (Italy); Elizalde, Emilio [Consejo Superior de Investigaciones Cientificas (ICE/CSIC) and Institut d' Estudis Espacials de Catalunya (IEEC), Facultat Ciencies, Bellaterra (Barcelona) (Spain); Nojiri, Shin' ichi [Nagoya University, Department of Physics, Nagoya (Japan); Odintsov, Sergei D. [Consejo Superior de Investigaciones Cientificas (ICE/CSIC) and Institut d' Estudis Espacials de Catalunya (IEEC), Facultat Ciencies, Bellaterra (Barcelona) (Spain); ICREA, Barcelona (Spain); TSPU, Center of Theor. Phys., Tomsk (Russian Federation)

    2009-12-15

    We discuss the classical and quantum properties of non-local modified Gauss-Bonnet gravity in de Sitter space, using its equivalent representation via string-inspired local scalar-Gauss-Bonnet gravity with a scalar potential. A classical, multiple de Sitter universe solution is found where one of the de Sitter phases corresponds to the primordial inflationary epoch, while the other de Sitter space solution - the one with the smallest Hubble rate - describes the late-time acceleration of our universe. A Chameleon scenario for the theory under investigation is developed, and it is successfully used to show that the theory complies with gravitational tests. An explicit expression for the one-loop effective action for this non-local modified Gauss-Bonnet gravity in the de Sitter space is obtained. It is argued that this effective action might be an important step towards the solution of the cosmological constant problem. (orig.)

  2. Computing wave functions in multichannel collisions with non-local potentials using the R-matrix method

    Science.gov (United States)

    Bonitati, Joey; Slimmer, Ben; Li, Weichuan; Potel, Gregory; Nunes, Filomena

    2017-09-01

    The calculable form of the R-matrix method has been previously shown to be a useful tool in approximately solving the Schrodinger equation in nuclear scattering problems. We use this technique combined with the Gauss quadrature for the Lagrange-mesh method to efficiently solve for the wave functions of projectile nuclei in low energy collisions (1-100 MeV) involving an arbitrary number of channels. We include the local Woods-Saxon potential, the non-local potential of Perey and Buck, a Coulomb potential, and a coupling potential to computationally solve for the wave function of two nuclei at short distances. Object oriented programming is used to increase modularity, and parallel programming techniques are introduced to reduce computation time. We conclude that the R-matrix method is an effective method to predict the wave functions of nuclei in scattering problems involving both multiple channels and non-local potentials. Michigan State University iCER ACRES REU.

  3. Delay-active damage versus non-local enhancement for anisotropic damage dynamics computations with alternated loading

    International Nuclear Information System (INIS)

    Desmorat, R.; Chambart, M.; Gatuingt, F.; Guilbaud, D.

    2010-01-01

    Anisotropic damage thermodynamics framework allows to model the concrete-like materials behavior and in particular their dissymmetric tension/compression response. To deal with dynamics applications such as impact, it is furthermore necessary to take into account the strain rate effect observed experimentally. This is done in the present work by means of anisotropic visco-damage, by introducing a material strain rate effect in the cases of positive hydrostatic stresses only. The proposed delay-damage law assumes no viscous effect in compression as the consideration of inertia effects proves sufficient to model the apparent material strength increase. High-rate dynamics applications imply to deal with wave propagation and reflection which can generate alternated loading in the impacted structure. In order to do so, the key concept of active damage is defined and introduced within both the damage criterion and the delay-damage evolution law. At the structural level, strain localization often leads to spurious mesh dependency. Three-dimensional Finite Element computations of dynamic tensile tests by spalling are presented, with visco-damage and either without or with non-local enhancement. Delay-damage, as introduced, regularizes the solution in fast dynamics. The location of the macro-crack initiated is found influenced by non-local regularization. The strain rate range in which each enhancement, delay-damage or non-local enhancement, has a regularizing effect is studied. (authors)

  4. Factorization and non-local 1/mb corrections in the decay anti B → Xsγ

    International Nuclear Information System (INIS)

    Benzke, Michael

    2011-01-01

    In this thesis, a systematic analysis of the anti B → X s γ photon spectrum in the endpoint region is presented. The endpoint region refers to a kinematic configuration of the final state, in which the photon has a large energy m b -2E γ =O(Λ QCD ), while the jet has a large energy but small invariant mass. Using methods of soft-collinear effective theory and heavy-quark effective theory, it is shown that the spectrum can be factorized into hard, jet, and soft functions, each encoding the dynamics at a certain scale. The relevant scales in the endpoint region are the heavy-quark mass m b , the hadronic energy scale Λ QCD and an intermediate scale √(Λ QCD m b ) associated with the invariant mass of the jet. It is found that the factorization formula contains two different types of contributions, distinguishable by the space-time structure of the underlying diagrams. On the one hand, there are the direct photon contributions which correspond to diagrams with the photon emitted directly from the weak vertex. The resolved photon contributions on the other hand arise at O(1/m b ) whenever the photon couples to light partons. In this work, these contributions are explicitly defined in terms of convolutions of jet functions with subleading shape functions. While the direct photon contributions can be expressed in terms of a local operator product expansion, when the photon spectrum is integrated over a range larger than the endpoint region, the resolved photon contributions always remain non-local. Thus, they are responsible for a non-perturbative uncertainty on the partonic predictions. In this thesis, the effect of these uncertainties is estimated in two different phenomenological contexts. First, the hadronic uncertainties in the anti B → X s γ branching fraction, defined with a cut E γ > 1.6GeV are discussed. It is found, that the resolved photon contributions give rise to an irreducible theory uncertainty of approximately 5%. As a second application of

  5. Adaptive non-local means on local principle neighborhood for noise/artifacts reduction in low-dose CT images.

    Science.gov (United States)

    Zhang, Yuanke; Lu, Hongbing; Rong, Junyan; Meng, Jing; Shang, Junliang; Ren, Pinghong; Zhang, Junying

    2017-09-01

    Low-dose CT (LDCT) technique can reduce the x-ray radiation exposure to patients at the cost of degraded images with severe noise and artifacts. Non-local means (NLM) filtering has shown its potential in improving LDCT image quality. However, currently most NLM-based approaches employ a weighted average operation directly on all neighbor pixels with a fixed filtering parameter throughout the NLM filtering process, ignoring the non-stationary noise nature of LDCT images. In this paper, an adaptive NLM filtering scheme on local principle neighborhoods (PC-NLM) is proposed for structure-preserving noise/artifacts reduction in LDCT images. Instead of using neighboring patches directly, in the PC-NLM scheme, the principle component analysis (PCA) is first applied on local neighboring patches of the target patch to decompose the local patches into uncorrelated principle components (PCs), then a NLM filtering is used to regularize each PC of the target patch and finally the regularized components is transformed to get the target patch in image domain. Especially, in the NLM scheme, the filtering parameter is estimated adaptively from local noise level of the neighborhood as well as the signal-to-noise ratio (SNR) of the corresponding PC, which guarantees a "weaker" NLM filtering on PCs with higher SNR and a "stronger" filtering on PCs with lower SNR. The PC-NLM procedure is iteratively performed several times for better removal of the noise and artifacts, and an adaptive iteration strategy is developed to reduce the computational load by determining whether a patch should be processed or not in next round of the PC-NLM filtering. The effectiveness of the presented PC-NLM algorithm is validated by experimental phantom studies and clinical studies. The results show that it can achieve promising gain over some state-of-the-art methods in terms of artifact suppression and structure preservation. With the use of PCA on local neighborhoods to extract principal structural

  6. The Effects of Long Duration Bed Rest on Functional Mobility and Balance: Relationship to Resting State Motor Cortex Connectivity

    Science.gov (United States)

    Erdeniz, B.; Koppelmans, V.; Bloomberg, J. J.; Kofman, I. S.; DeDios, Y. E.; Riascos-Castaneda, R. F.; Wood, S. J.; Mulavara, A. P.; Seidler, R. D.

    2014-01-01

    NASA offers researchers from a variety of backgrounds the opportunity to study bed rest as an experimental analog for space flight. Extended exposure to a head-down tilt position during long duration bed rest can resemble many of the effects of a low-gravity environment such as reduced sensory inputs, body unloading and increased cephalic fluid distribution. The aim of our study is to a) identify changes in brain function that occur with prolonged bed rest and characterize their recovery time course; b) assess whether and how these changes impact behavioral and neurocognitive performance. Thus far, we completed data collection from six participants that include task based and resting state fMRI. The data have been acquired through the bed rest facility located at the University of Texas Medical Branch (Galveston, TX). Subjects remained in bed with their heads tilted down 6 degrees below their feet for 70 consecutive days. Behavioral measures and neuroimaging assessments were obtained at seven time points: a) 7 and 12 days before bed rest; b) 7, 30, and 65 days during bed rest; and c) 7 and 12 days after bed rest. Functional connectivity magnetic resonance imaging (FcMRI) analysis was performed to assess the connectivity of motor cortex in and out of bed rest. We found a decrease in motor cortex connectivity with vestibular cortex and the cerebellum from pre bed rest to in bed rest. We also used a battery of behavioral measures including the functional mobility test and computerized dynamic posturography collected before and after bed rest. We will report the preliminary results of analyses relating brain and behavior changes. Furthermore, we will also report the preliminary results of a spatial working memory task and vestibular stimulation during in and out of bed rest.

  7. EMF-REST: Generation of RESTful APIs from Models

    OpenAIRE

    Hamza , Ed-Douibi; Cánovas Izquierdo , Javier Luis; Gómez , Abel; Tisi , Massimo; Cabot , Jordi

    2016-01-01

    In the last years, RESTful Web services have become more and more popular as a lightweight solution to connect remote systems in distributed and Cloud-based architectures. However, being an architectural style rather than a specification or standard, the proper design of RESTful Web services is not trivial since developers have to deal with a plethora of recommendations and best practices. Model-Driven Engineering (MDE) emphasizes the use of models and model transformations to raise the level...

  8. Free vibration analysis of a magneto-electro-elastic doubly-curved shell resting on a Pasternak-type elastic foundation

    International Nuclear Information System (INIS)

    Razavi, Soheil; Shooshtari, Alireza

    2014-01-01

    Free vibration of a simply-supported magneto-electro-elastic doubly-curved thin shell resting on a Pasternak foundation is investigated based on Donnell theory. The rotary inertia effect is considered in the formulation. Maxwell equations for electrostatics and magnetostatics are used to model the electric and magnetic behavior. The partial differential equations of motion are reduced to a single ordinary differential equation and an analytical relation is obtained for the natural frequency. After validation of the present study, several numerical studies is done to investigate the effects of the electric and magnetic potentials, spring and shear coefficients of the Pasternak foundation, and the geometry of the shell on the vibration frequency. (paper)

  9. Clinical physiology of bed rest

    Science.gov (United States)

    Greenleaf, John E.

    1993-01-01

    Maintenance of optimal health in humans requires the proper balance between exercise, rest, and sleep as well as time in the upright position. About one-third of a lifetime is spent sleeping; and it is no coincidence that sleeping is performed in the horizontal position, the position in which gravitational influence on the body is minimal. Although enforced bed rest is necessary for the treatment of some ailments, in some cases it has probably been used unwisely. In addition to the lower hydrostatic pressure with the normally dependent regions of the cardiovascular system, body fuid compartments during bed rest in the horizontal body position, and virtual elimination of compression on the long bones of the skeletal system during bed rest (hypogravia), there is often reduction in energy metabolism due to the relative confinement (hypodynamia) and alteration of ambulatory circadian variations in metabolism, body temperature, and many hormonal systems. If patients are also moved to unfamiliar surroundings, they probably experience some feelings of anxiety and some sociopsychological problems. Adaptive physiological responses during bed rest are normal for that environment. They are attempts by the body to reduce unnecessary energy expenditure, to optimize its function, and to enhance its survival potential. Many of the deconditioning responses begin within the first day or two of bed rest; these early responses have prompted physicians to insist upon early resumption of the upright posture and ambulation of bedridden patients.

  10. Clustering of resting state networks.

    Directory of Open Access Journals (Sweden)

    Megan H Lee

    Full Text Available The goal of the study was to demonstrate a hierarchical structure of resting state activity in the healthy brain using a data-driven clustering algorithm.The fuzzy-c-means clustering algorithm was applied to resting state fMRI data in cortical and subcortical gray matter from two groups acquired separately, one of 17 healthy individuals and the second of 21 healthy individuals. Different numbers of clusters and different starting conditions were used. A cluster dispersion measure determined the optimal numbers of clusters. An inner product metric provided a measure of similarity between different clusters. The two cluster result found the task-negative and task-positive systems. The cluster dispersion measure was minimized with seven and eleven clusters. Each of the clusters in the seven and eleven cluster result was associated with either the task-negative or task-positive system. Applying the algorithm to find seven clusters recovered previously described resting state networks, including the default mode network, frontoparietal control network, ventral and dorsal attention networks, somatomotor, visual, and language networks. The language and ventral attention networks had significant subcortical involvement. This parcellation was consistently found in a large majority of algorithm runs under different conditions and was robust to different methods of initialization.The clustering of resting state activity using different optimal numbers of clusters identified resting state networks comparable to previously obtained results. This work reinforces the observation that resting state networks are hierarchically organized.

  11. Changes in resting-state brain function of pilots after hypoxic exposure based on methods for fALFF and ReHo analysis

    Directory of Open Access Journals (Sweden)

    Jie LIU

    2015-07-01

    Full Text Available Objective The objective of this study was to evaluate the basic changes in brain activity of pilots after hypoxic exposure with the use of resting-state functional magnetic resonance imaging (rs-fMRI and regional homogeneity (ReHo method. Methods Thirty healthy male pilots were successively subjected to normal and hypoxic exposure (with an oxygen concentration of 14.5%. Both the fALFF and ReHo methods were adopted to analyze the resting-state functional MRI data before and after hypoxic exposure of the subjects, the areas of the brain with fALFF and ReHo changes after hypoxic exposure were observed. Results  After hypoxic exposure, the pulse was 64.0±10.6 beats/min, and the oxygen saturation was 92.4%±3.9% in these 30 pilots, and it was lower than those before exposure (71.4±10.9 beats/min, 96.3%±1.3%, P<0.05. Compared with the condition before hypoxic exposure, the fALFF value was decreased in superior temporal gyri on both sides and the right superior frontal gyrus, and increase in the left precuneus, while the value of ReHo was decreased in the right superior frontal gyrus (P<0.05. No brain area with an increase in ReHo value was found. Conclusions Hypoxic exposure could significantly affect the brain functions of pilots, which may contribute to change in their cognitive ability. DOI: 10.11855/j.issn.0577-7402.2015.06.18

  12. A Non-local Model for Transient Moisture Flow in Unsaturated Soils Based on the Peridynamic Theory

    Science.gov (United States)

    Jabakhanji, R.; Mohtar, R. H.

    2012-12-01

    A non-local, gradient free, formulation of the porous media flow problem in unsaturated soils was derived. It parallels the peridynamic theory, a non-local reformulation of solid mechanics presented by Silling. In the proposed model, the evolution of the state of a material point is driven by pairwise interactions with other points across finite distances. Flow and changes in moisture are the result of these interactions. Instead of featuring local gradients, the proposed model expresses the flow as a functional integral of the hydraulic potential field. The absence of spatial gradients, undefined at or on discontinuities, makes the model a good candidate for flow simulations in fractured soils. It also lends itself to coupling with peridynamic mechanical models for simulating crack formation triggered by shrinkage and swelling, and assessing their potential impact on a wide range of processes, such as infiltration, contaminant transport, slope stability and integrity of clay barriers. A description of the concept and an outline of the derivation and numerical implementation are presented. Simulation results of infiltration and drainage for 1D, single and two-layers soil columns, for three different soil types are also presented. The same simulations are repeated using HYDRUS-1D, a computer model using the classic local flow equation. We show that the proposed non-local formulation successfully reproduces the results from HYDRUS-1D. S.A. Silling, "Reformulation of Elasticity Theory for Discontinuities and Long-range Forces," Journal of the Mechanics and Physics of Solids 48, no. 1 (January 2000): 175-209. J. Simunek, M. Sejna, and M.T. Van Genuchten, "The HYDRUS-1D Software Package for Simulating the One-dimensional Movement of Water, Heat, and Multiple Solutes in Variably-saturated Media," University of California, Riverside, Research Reports 240 (2005).

  13. Locality or non-locality in quantum mechanics: hidden variables without ''spooky action-at-a-distance''

    International Nuclear Information System (INIS)

    Aharonov, Y.; Scully, M.

    2001-01-01

    The folklore notion of the ''Non-Locality of Quantum Mechanics'' is examined from the point of view of hidden-variables theories according to Belinfante's classification in his Survey of Hidden Variables Theories. It is here shown that in the case of EPR, there exist hidden variables theories that successfully reproduce quantum-mechanical predictions, but which are explicitly local. Since such theories do not fall into Belinfante's classification, we propose an expanded classification which includes similar theories, which we term as theories of the ''third'' kind. Causal implications of such theories are explored. (orig.)

  14. On the structure on non-local conservation laws in the two-dimensional non-linear sigma-model

    International Nuclear Information System (INIS)

    Zamolodchikov, Al.B.

    1978-01-01

    The non-local conserved charges are supposed to satisfy a special multiplicative law in the space of asymptotic states of the non-linear sigma-model. This supposition leads to factorization equations for two-particle scattering matrix elements and determines to some extent the action of these charges in the asymptotic space. Their conservation turns out to be consistent with the factorized S-matrix of the non-linear sigma-model. It is shown also that the factorized sine-Gordon S-matrix is consistent with a similar family of conservation laws

  15. Do EPR-Bell correlations require a non-local interpretation of quantum mechanics? I: Wigner approach

    International Nuclear Information System (INIS)

    Scully, Marlan O.; Erez, Noam; Fry, Edward S.

    2005-01-01

    Bell inequality experiments teach us that, to explain the data, a hidden variable theory must be non-local. But, to also apply this conclusion to quantum mechanics is unjustified. The key assumptions required to obtain a Bell inequality are (1) locality and (2) the assignment of meaningful (non-negative) probabilities to seemingly physical correlations (Bell expresses these correlations via 'hidden variables'). Since the Bell inequality is violated by experiment, at least one of these assumptions is wrong. The widespread conclusion that locality must be relinquished is unwarranted; rather, the previously mentioned correlations are not physical observables-they are not elements of physical reality

  16. Four-cluster chimera state in non-locally coupled phase oscillator systems with an external potential

    International Nuclear Information System (INIS)

    Zhu Yun; Zheng Zhi-Gang; Yang Jun-Zhong

    2013-01-01

    Dynamics of a one-dimensional array of non-locally coupled Kuramoto phase oscillators with an external potential is studied. A four-cluster chimera state is observed for the moderate strength of the external potential. Different from the clustered chimera states studied before, the instantaneous frequencies of the oscillators in a synchronized cluster are different in the presence of the external potential. As the strength of the external potential increases, a bifurcation from the two-cluster chimera state to the four-cluster chimera states can be found. These phenomena are well predicted analytically with the help of the Ott—Antonsen ansatz. (general)

  17. The imaginary part of the local potential equivalent to the non-local α-nucleus optical potential

    International Nuclear Information System (INIS)

    Lassaut, M.; Vinh Mau, N.

    1982-01-01

    A simple expression of the α-nucleus optical potential has been derived from the Feshbach formula by using a closure approximation for summing over the excited states of the target nucleus. It has been shown that the correction to the real folding model potential is small. The imaginary local potential equivalent to the non-local Feshbach potential has been studied in detail for Ca nuclei and shown to reproduce quite well the gross properties of empirical potentials above 100 MeV with, however, a lack of absorption in the surface region. The A-dependence of the imaginary potential volume integral has also been investigated. (orig.)

  18. Cerebral Blood Flow during Rest Associates with General Intelligence and Creativity

    Science.gov (United States)

    Takeuchi, Hikaru; Taki, Yasuyuki; Hashizume, Hiroshi; Sassa, Yuko; Nagase, Tomomi; Nouchi, Rui; Kawashima, Ryuta

    2011-01-01

    Recently, much scientific attention has been focused on resting brain activity and its investigation through such methods as the analysis of functional connectivity during rest (the temporal correlation of brain activities in different regions). However, investigation of the magnitude of brain activity during rest has focused on the relative decrease of brain activity during a task, rather than on the absolute resting brain activity. It is thus necessary to investigate the association between cognitive factors and measures of absolute resting brain activity, such as cerebral blood flow (CBF), during rest (rest-CBF). In this study, we examined this association using multiple regression analyses. Rest-CBF was the dependent variable and the independent variables included two essential components of cognitive functions, psychometric general intelligence and creativity. CBF was measured using arterial spin labeling and there were three analyses for rest-CBF; namely mean gray matter rest-CBF, mean white matter rest-CBF, and regional rest-CBF. The results showed that mean gray and white matter rest-CBF were significantly and positively correlated with individual psychometric intelligence. Furthermore, mean white matter rest-CBF was significantly and positively correlated with creativity. After correcting the effect of mean gray matter rest-CBF the significant and positive correlation between regional rest-CBF in the perisylvian anatomical cluster that includes the left superior temporal gyrus and insula and individual psychometric intelligence was found. Also, regional rest-CBF in the precuneus was significantly and negatively correlated with individual creativity. Significance of these results of regional rest-CBF did not change when the effect of regional gray matter density was corrected. The findings showed mean and regional rest-CBF in healthy young subjects to be correlated with cognitive functions. The findings also suggest that, even in young cognitively intact

  19. Connectomic markers of symptom severity in sport-related concussion: Whole-brain analysis of resting-state fMRI

    Directory of Open Access Journals (Sweden)

    Nathan W. Churchill

    Full Text Available Concussion is associated with significant adverse effects within the first week post-injury, including physical complaints and altered cognition, sleep and mood. It is currently unknown whether these subjective disturbances have reliable functional brain correlates. Resting-state functional magnetic resonance imaging (rs-fMRI has been used to measure functional connectivity of individuals after traumatic brain injury, but less is known about the relationship between functional connectivity and symptom assessments after a sport concussion. In this study, rs-fMRI was used to evaluate whole-brain functional connectivity for seventy (70 university-level athletes, including 35 with acute concussion and 35 healthy matched controls. Univariate analyses showed that greater symptom severity was mainly associated with lower pairwise connectivity in frontal, temporal and insular regions, along with higher connectivity in a sparser set of cerebellar regions. A novel multivariate approach also extracted two components that showed reliable covariation with symptom severity: (1 a network of frontal, temporal and insular regions where connectivity was negatively correlated with symptom severity (replicating the univariate findings; and (2 a network with anti-correlated elements of the default-mode network and sensorimotor system, where connectivity was positively correlated with symptom severity. These findings support the presence of connectomic signatures of symptom complaints following a sport-related concussion, including both increased and decreased functional connectivity within distinct functional brain networks. Keywords: fMRI, Functional connectivity, Concussion, Brain injury, Symptoms

  20. Connectomic markers of symptom severity in sport-related concussion: Whole-brain analysis of resting-state fMRI.

    Science.gov (United States)

    Churchill, Nathan W; Hutchison, Michael G; Graham, Simon J; Schweizer, Tom A

    2018-01-01

    Concussion is associated with significant adverse effects within the first week post-injury, including physical complaints and altered cognition, sleep and mood. It is currently unknown whether these subjective disturbances have reliable functional brain correlates. Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to measure functional connectivity of individuals after traumatic brain injury, but less is known about the relationship between functional connectivity and symptom assessments after a sport concussion. In this study, rs-fMRI was used to evaluate whole-brain functional connectivity for seventy (70) university-level athletes, including 35 with acute concussion and 35 healthy matched controls. Univariate analyses showed that greater symptom severity was mainly associated with lower pairwise connectivity in frontal, temporal and insular regions, along with higher connectivity in a sparser set of cerebellar regions. A novel multivariate approach also extracted two components that showed reliable covariation with symptom severity: (1) a network of frontal, temporal and insular regions where connectivity was negatively correlated with symptom severity (replicating the univariate findings); and (2) a network with anti-correlated elements of the default-mode network and sensorimotor system, where connectivity was positively correlated with symptom severity. These findings support the presence of connectomic signatures of symptom complaints following a sport-related concussion, including both increased and decreased functional connectivity within distinct functional brain networks.

  1. Resting states are resting traits--an FMRI study of sex differences and menstrual cycle effects in resting state cognitive control networks.

    Science.gov (United States)

    Hjelmervik, Helene; Hausmann, Markus; Osnes, Berge; Westerhausen, René; Specht, Karsten

    2014-01-01

    To what degree resting state fMRI is stable or susceptible to internal mind states of the individual is currently an issue of debate. To address this issue, the present study focuses on sex differences and investigates whether resting state fMRI is stable in men and women or changes within relative short-term periods (i.e., across the menstrual cycle). Due to the fact that we recently reported menstrual cycle effects on cognitive control based on data collected during the same sessions, the current study is particularly interested in fronto-parietal resting state networks. Resting state fMRI was measured in sixteen women during three different cycle phases (menstrual, follicular, and luteal). Fifteen men underwent three sessions in corresponding time intervals. We used independent component analysis to identify four fronto-parietal networks. The results showed sex differences in two of these networks with women exhibiting higher functional connectivity in general, including the prefrontal cortex. Menstrual cycle effects on resting states were non-existent. It is concluded that sex differences in resting state fMRI might reflect sexual dimorphisms in the brain rather than transitory activating effects of sex hormones on the functional connectivity in the resting brain.

  2. On the dynamics of a non-local parabolic equation arising from the Gierer-Meinhardt system

    Science.gov (United States)

    Kavallaris, Nikos I.; Suzuki, Takashi

    2017-05-01

    The purpose of the current paper is to contribute to the comprehension of the dynamics of the shadow system of an activator-inhibitor system known as a Gierer-Meinhardt model. Shadow systems are intended to work as an intermediate step between single equations and reaction-diffusion systems. In the case where the inhibitor’s response to the activator’s growth is rather weak, then the shadow system of the Gierer-Meinhardt model is reduced to a single though non-local equation whose dynamics will be investigated. We mainly focus on the derivation of blow-up results for this non-local equation which can be seen as instability patterns of the shadow system. In particular, a diffusion driven instability (DDI), or Turing instability, in the neighbourhood of a constant stationary solution, which it is destabilised via diffusion-driven blow-up, is obtained. The latter actually indicates the formation of some unstable patterns, whilst some stability results of global-in-time solutions towards non-constant steady states guarantee the occurrence of some stable patterns.

  3. Instantaneous equations for multiphase flow in porous media without length-scale restrictions using a non-local averaging volume

    International Nuclear Information System (INIS)

    Espinosa-Paredes, Gilberto

    2010-01-01

    The aim of this paper is to propose a framework to obtain a new formulation for multiphase flow conservation equations without length-scale restrictions, based on the non-local form of the averaged volume conservation equations. The simplification of the local averaging volume of the conservation equations to obtain practical equations is subject to the following length-scale restrictions: d << l << L, where d is the characteristic length of the dispersed phases, l is the characteristic length of the averaging volume, and L is the characteristic length of the physical system. If the foregoing inequality does not hold, or if the scale of the problem of interest is of the order of l, the averaging technique and therefore, the macroscopic theories of multiphase flow should be modified in order to include appropriate considerations and terms in the corresponding equations. In these cases the local form of the averaged volume conservation equations are not appropriate to describe the multiphase system. As an example of the conservation equations without length-scale restrictions, the natural circulation boiling water reactor was consider to study the non-local effects on the thermal-hydraulic core performance during steady-state and transient behaviors, and the results were compared with the classic local averaging volume conservation equations.

  4. The Robin Hood method - A novel numerical method for electrostatic problems based on a non-local charge transfer

    International Nuclear Information System (INIS)

    Lazic, Predrag; Stefancic, Hrvoje; Abraham, Hrvoje

    2006-01-01

    We introduce a novel numerical method, named the Robin Hood method, of solving electrostatic problems. The approach of the method is closest to the boundary element methods, although significant conceptual differences exist with respect to this class of methods. The method achieves equipotentiality of conducting surfaces by iterative non-local charge transfer. For each of the conducting surfaces, non-local charge transfers are performed between surface elements, which differ the most from the targeted equipotentiality of the surface. The method is tested against analytical solutions and its wide range of application is demonstrated. The method has appealing technical characteristics. For the problem with N surface elements, the computational complexity of the method essentially scales with N α , where α < 2, the required computer memory scales with N, while the error of the potential decreases exponentially with the number of iterations for many orders of magnitude of the error, without the presence of the Critical Slowing Down. The Robin Hood method could prove useful in other classical or even quantum problems. Some future development ideas for possible applications outside electrostatics are addressed

  5. RESTful Java web services security

    CERN Document Server

    Enríquez, René

    2014-01-01

    A sequential and easy-to-follow guide which allows you to understand the concepts related to securing web apps/services quickly and efficiently, since each topic is explained and described with the help of an example and in a step-by-step manner, helping you to easily implement the examples in your own projects. This book is intended for web application developers who use RESTful web services to power their websites. Prior knowledge of RESTful is not mandatory, but would be advisable.

  6. Information Flow Between Resting-State Networks.

    Science.gov (United States)

    Diez, Ibai; Erramuzpe, Asier; Escudero, Iñaki; Mateos, Beatriz; Cabrera, Alberto; Marinazzo, Daniele; Sanz-Arigita, Ernesto J; Stramaglia, Sebastiano; Cortes Diaz, Jesus M

    2015-11-01

    The resting brain dynamics self-organize into a finite number of correlated patterns known as resting-state networks (RSNs). It is well known that techniques such as independent component analysis can separate the brain activity at rest to provide such RSNs, but the specific pattern of interaction between RSNs is not yet fully understood. To this aim, we propose here a novel method to compute the information flow (IF) between different RSNs from resting-state magnetic resonance imaging. After hemodynamic response function blind deconvolution of all voxel signals, and under the hypothesis that RSNs define regions of interest, our method first uses principal component analysis to reduce dimensionality in each RSN to next compute IF (estimated here in terms of transfer entropy) between the different RSNs by systematically increasing k (the number of principal components used in the calculation). When k=1, this method is equivalent to computing IF using the average of all voxel activities in each RSN. For k≥1, our method calculates the k multivariate IF between the different RSNs. We find that the average IF among RSNs is dimension dependent, increasing from k=1 (i.e., the average voxel activity) up to a maximum occurring at k=5 and to finally decay to zero for k≥10. This suggests that a small number of components (close to five) is sufficient to describe the IF pattern between RSNs. Our method--addressing differences in IF between RSNs for any generic data--can be used for group comparison in health or disease. To illustrate this, we have calculated the inter-RSN IF in a data set of Alzheimer's disease (AD) to find that the most significant differences between AD and controls occurred for k=2, in addition to AD showing increased IF w.r.t. The spatial localization of the k=2 component, within RSNs, allows the characterization of IF differences between AD and controls.

  7. Composition and partition functions of partially ionized hydrogen plasma in Non-Local Thermal Equilibrium (Non-LThE) and Non-Local Chemical Equilibrium (Non-LChE)

    International Nuclear Information System (INIS)

    Chen Kuan; Eddy, T.L.

    1993-01-01

    A GTME (Generalized MultiThermodynamic Equilibrium) plasma model is developed for plasmas in both Non-LThE (Non-Local Thermal Equilibrium) and Non-LChE (Non-Local Chemical Equilibrium). The model uses multitemperatures for thermal nonequilibrium and non-zero chemical affinities as a measure of the deviation from chemical equilibrium. The plasma is treated as an ideal gas with the Debye-Hueckel approximation employed for pressure correction. The proration method is used when the cutoff energy level is between two discrete levels. The composition and internal partition functions of a hydrogen plasma are presented for electron temperatures ranging from 5000 to 35000 K and pressures from 0.1 to 1000 kPa. Number densities of 7 different species of hydrogen plasma and internal partition functions of different energy modes (rotational, vibrational, and electronic excitation) are computed for three affinity values. The results differ from other plasma properties in that they 1) are not based on equilibrium properties; and 2) are expressed as a function of different energy distribution parameters (temperatures) within each energy mode of each species as appropriate. The computed number densities and partition functions are applicable to calculating the thermodynamic, transport, and radiation properties of a hydrogen plasma not in thermal and chemical equilibria. The nonequilibrium plasma model and plasma compositions presented in this paper are very useful to the diagnosis of high-speed and/or low-pressure plasma flows in which the assumptions of local thermal and chemical equilibrium are invalid. (orig.)

  8. Do resting brain dynamics predict oddball evoked-potential?

    Directory of Open Access Journals (Sweden)

    Lee Tien-Wen

    2011-11-01

    Full Text Available Abstract Background The oddball paradigm is widely applied to the investigation of cognitive function in neuroscience and in neuropsychiatry. Whether cortical oscillation in the resting state can predict the elicited oddball event-related potential (ERP is still not clear. This study explored the relationship between resting electroencephalography (EEG and oddball ERPs. The regional powers of 18 electrodes across delta, theta, alpha and beta frequencies were correlated with the amplitude and latency of N1, P2, N2 and P3 components of oddball ERPs. A multivariate analysis based on partial least squares (PLS was applied to further examine the spatial pattern revealed by multiple correlations. Results Higher synchronization in the resting state, especially at the alpha spectrum, is associated with higher neural responsiveness and faster neural propagation, as indicated by the higher amplitude change of N1/N2 and shorter latency of P2. None of the resting quantitative EEG indices predict P3 latency and amplitude. The PLS analysis confirms that the resting cortical dynamics which explains N1/N2 amplitude and P2 latency does not show regional specificity, indicating a global property of the brain. Conclusions This study differs from previous approaches by relating dynamics in the resting state to neural responsiveness in the activation state. Our analyses suggest that the neural characteristics carried by resting brain dynamics modulate the earlier/automatic stage of target detection.

  9. Turbulent intermittent structure in non-homogeneous non-local flows

    Science.gov (United States)

    Mahjoub, O. B.; Castilla, R.; Vindel, J. M.; Redondo, J. M.

    2010-05-01

    Data from SABLES98 experimental campaign have been used in order to study the influence of stability (from weak to strong stratification) on intermittency [1]. Standard instrumentation, 14 thermocouples and 3 sonic anemometers at three levels (5.8, 13.5 and 32 m) were available in September 1998 and calculations are done in order to evaluate structure functions and the scale to scale characteristics. Using BDF [2-4] as well as other models of cascades, the spectral equilibrium values were used to calculate fluxes of momentum and heat as well as non-homogeneous models and the turbulent mixing produced. The differences in structure and higher order moments between stable, convective and neutral turbulence were used to identify differences in turbulent intermittent mixing and velocity PDF's. The intermittency of atmospheric turbulence in strongly stable situations affected by buoyancy and internal waves are seen to modify the structure functions exponents and intermittency, depending on the modulus of the Richardson's number,Ri, as well as of the Monin-Obukhov and Ozmidov lengthscales. The topological aspects of the turbulence affected by stratification reduce the vertical length-scales to a maximum described by the Thorpe and the Ozmidov lenth-scales, but intermittency, Kurtosis and other higher order descriptors of the turbulence based on spectral wavelet analysis are also affected in a complex way [5,6]. The relationship between stratification, intermittency, µ(Ri) and the fractal dimension of the stable flows and between the dispersion, the fractal dimension are discussed. The data analyzed is from the campaign SABLES-98 at the north-west Iberian Peninsula plateau.(Cuxart et al. 2000). Conditional statistics of the relationship between µ(Ri) are confirmed as in (Vindel et al 2008)[4] and compared with laboratory experiments and with 2D-3D aspects of the turbulence cascade. The use of BDF [3] model comparing the corresponding relative scaling exponents which are

  10. The NASA Bed Rest Project

    Science.gov (United States)

    Rhodes, Bradley; Meck, Janice

    2005-01-01

    NASA s National Vision for Space Exploration includes human travel beyond low earth orbit and the ultimate safe return of the crews. Crucial to fulfilling the vision is the successful and timely development of countermeasures for the adverse physiological effects on human systems caused by long term exposure to the microgravity environment. Limited access to in-flight resources for the foreseeable future increases NASA s reliance on ground-based analogs to simulate these effects of microgravity. The primary analog for human based research will be head-down bed rest. By this approach NASA will be able to evaluate countermeasures in large sample sizes, perform preliminary evaluations of proposed in-flight protocols and assess the utility of individual or combined strategies before flight resources are requested. In response to this critical need, NASA has created the Bed Rest Project at the Johnson Space Center. The Project establishes the infrastructure and processes to provide a long term capability for standardized domestic bed rest studies and countermeasure development. The Bed Rest Project design takes a comprehensive, interdisciplinary, integrated approach that reduces the resource overhead of one investigator for one campaign. In addition to integrating studies operationally relevant for exploration, the Project addresses other new Vision objectives, namely: 1) interagency cooperation with the NIH allows for Clinical Research Center (CRC) facility sharing to the benefit of both agencies, 2) collaboration with our International Partners expands countermeasure development opportunities for foreign and domestic investigators as well as promotes consistency in approach and results, 3) to the greatest degree possible, the Project also advances research by clinicians and academia alike to encourage return to earth benefits. This paper will describe the Project s top level goals, organization and relationship to other Exploration Vision Projects, implementation

  11. Non-local rheology of stony debris flow propagating over a cohesionless sediment bed

    Science.gov (United States)

    Lanzoni, Stefano; Gregoretti, Carlo

    2016-04-01

    Velocity profiles of gravel-water mixtures observed in flume experiments often exhibit a double-slope behavior, with a lower narrower region where the velocity increases slowly, and an upper wider region often exhibiting a nearly linear behavior. Even though the flow can be classified within the grain-inertia regime, the overall profile seems to not conform to the power law (with exponent 1.5) distribution obtained by integrating along the normal to the flow the dispersive stresses envisaged by Bagnold (1954) in his pioneer work. Note that this formulation neglects the contribution to the velocity profile of the quasi-static (frictional) stresses that tend to dominate close to an erodible sediment bottom. The present work investigates the possibility to find out a uniformly valid distribution of shear stress from the bottom to the flow surface. To this aim we follow a heuristic coherence length approach (GDR-MIDI, 2004) similar to the mixing length procedure commonly used to study the atmospheric boundary layer over canopy (see, e.g., Harmann and Finnegan, 2007). A database built on 64 systematic debris flow experiments is used to disclose the general features of velocity profiles that establish within the body of almost steady water-sediment flows and the dependence of transport sediment volumetric concentration on the relevant parameters. The almost steady water-sediment flows considered in the study were generated by releasing a prescribed water discharge on a saturated layer of sediment (specifically, 3 mm gravel, 6 mm gravel, and 3 mm glass spheres) initially placed in a 10 m long and 0.2 m wide laboratory flume. The analysis clearly indicates that stony debris flow conditions characterized the experiments. The mixing length does not result constant, as required by a Bagnold-like profile, but varies gradually, from zero at the flow surface, to a finite value near the erodible bottom. We discuss this structure in terms of shear stress distribution along the

  12. Expanded functional coupling of subcortical nuclei with the motor resting-state network in multiple sclerosis

    DEFF Research Database (Denmark)

    Dogonowski, Anne-Marie; Siebner, Hartwig R; Sørensen, Per Soelberg

    2013-01-01

    controls underwent a 20-minute resting-state fMRI session at 3 Tesla. Independent component analysis was applied to the fMRI data to identify disease-related changes in motor resting-state connectivity. RESULTS: Patients with MS showed a spatial expansion of motor resting-state connectivity in deep...

  13. Probing the quantum correlation and Bell non-locality for Dirac particles with Hawking effect in the background of Schwarzschild black hole

    International Nuclear Information System (INIS)

    Xu, Shuai; Song, Xue-ke; Shi, Jia-dong; Ye, Liu

    2014-01-01

    In this Letter, we analytically explore the effect of the Hawking radiation on the quantum correlation and Bell non-locality for Dirac particles in the background of Schwarzschild black hole. It is shown that when the Hawking effect is almost nonexistent, corresponding to the case of an almost extreme black hole, the quantum properties of physically accessible state are the same for the initial situation. For finite Hawking temperature T, the accessible quantum correlation monotonously decreases along with increasing T owing to the thermal fields generated by the Hawking effect, and the accessible quantum non-locality will be disappeared when the Hawking temperature is more than a fixed value which increases with the parameter r of Werner state growing. Then we analyze the redistribution of quantum correlation, and find that for the case of the Hawking temperature being infinite, corresponding to the case of the black hole evaporating completely, the quantum correlation of physically accessible state is equal to the one of the inaccessible states. Moreover, due to the Pauli exclusion principle and the differences between Fermi–Dirac and Bose–Einstein statistics, for the Dirac fields the accessible classical correlation decreases with increase of the Hawking temperature, which is different for the scalar fields. For Bell non-locality, we also find that the quantum non-locality is always extinct for physically inaccessible states, and the strength of the non-locality decreases with enlarging intensity of Hawking effect when the non-locality is existent in physically accessible state.

  14. N = 2 local and N = 4 non-local reductions of supersymmetric KP hierarchy in N = 2 superspace

    International Nuclear Information System (INIS)

    Delduc, F.; Gallot, L.; Sorin, A.

    1999-01-01

    An N = 4 supersymmetric matrix KP hierarchy is proposed and a wide class of its reductions which are characterized by a finite number of fields are described. This class includes the one-dimensional reduction of the two-dimensional N = (2,2) superconformal Toda lattice hierarchy possessing the N = 4 supersymmetry -- the N = 4 Toda chain hierarchy - which may be relevant in the construction of supersymmetric matrix models. The Lax-pair representations of the bosonic and fermionic flows, corresponding local and non-local Hamiltonians, finite and infinite discrete symmetries, the first two Hamiltonian structures and the recursion operator connecting all evolution equations and the Hamiltonian structures of the N = 4 Toda chain hierarchy are constructed in explicit form. Is secondary reduction to the N 4 supersymmetric α = - 2 KdV hierarchy is

  15. Simulation of delamination crack growth in composite laminates: application of local and non-local interface damage models

    International Nuclear Information System (INIS)

    Ijaz, H.; Asad, M.

    2015-01-01

    The use of composite laminates is increasing in these days due to higher strength and low density values in comparison of metals. Delamination is a major source of failure in composite laminates. Damage mechanics based theories are employed to simulate the delamination phenomena between composite laminates. These damage models are inherently local and can cause the concentration of stresses around the crack tip. In the present study integral type non-local damage formulation is proposed to avoid the localization problem associated to damage formulation. A comprehensive study is carried out for the models and classical local damage model are performed and results are compared with available experimental data for un IMS/924 Carbon/fiber epoxy composite laminate. (author)

  16. Disorder in materials with complex crystal structures: the Non-Local Coherent Potential Approximation for compounds with multiple sublattices

    International Nuclear Information System (INIS)

    Marmodoro, A; Staunton, J B

    2011-01-01

    Over the last few years the Non-Local Coherent Potential Approximation (NL-CPA) has been shown to provide an effective way to describe the electronic structure and related properties of disordered systems, where short-range order (SRO) and other local environment effects are important. Here we present its generalization to materials with multi-atom per unit cell lattices. The method is described using a Green function formalism and illustrated by an implementation for a simplified one-dimensional tight-binding model with substitutional disorder. This development paves the way for a natural reimplementation of the Korringa-Kohn-Rostoker (KKR) multiple scattering solution of Kohn-Sham equations for ab-initio calculations of real materials.

  17. Probing the structural and dynamical properties of liquid water with models including non-local electron correlation

    International Nuclear Information System (INIS)

    Del Ben, Mauro; Hutter, Jürg; VandeVondele, Joost

    2015-01-01

    Water is a ubiquitous liquid that displays a wide range of anomalous properties and has a delicate structure that challenges experiment and simulation alike. The various intermolecular interactions that play an important role, such as repulsion, polarization, hydrogen bonding, and van der Waals interactions, are often difficult to reproduce faithfully in atomistic models. Here, electronic structure theories including all these interactions at equal footing, which requires the inclusion of non-local electron correlation, are used to describe structure and dynamics of bulk liquid water. Isobaric-isothermal (NpT) ensemble simulations based on the Random Phase Approximation (RPA) yield excellent density (0.994 g/ml) and fair radial distribution functions, while various other density functional approximations produce scattered results (0.8-1.2 g/ml). Molecular dynamics simulation in the microcanonical (NVE) ensemble based on Møller-Plesset perturbation theory (MP2) yields dynamical properties in the condensed phase, namely, the infrared spectrum and diffusion constant. At the MP2 and RPA levels of theory, ice is correctly predicted to float on water, resolving one of the anomalies as resulting from a delicate balance between van der Waals and hydrogen bonding interactions. For several properties, obtaining quantitative agreement with experiment requires correction for nuclear quantum effects (NQEs), highlighting their importance, for structure, dynamics, and electronic properties. A computed NQE shift of 0.6 eV for the band gap and absorption spectrum illustrates the latter. Giving access to both structure and dynamics of condensed phase systems, non-local electron correlation will increasingly be used to study systems where weak interactions are of paramount importance

  18. RESTful web services with Dropwizard

    CERN Document Server

    Dallas, Alexandros

    2014-01-01

    A hands-on focused step-by-step tutorial to help you create Web Service applications using Dropwizard. If you are a software engineer or a web developer and want to learn more about building your own Web Service application, then this is the book for you. Basic knowledge of Java and RESTful Web Service concepts is assumed and familiarity with SQL/MySQL and command-line scripting would be helpful.

  19. WEB-SERVICE. RESTFUL ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    M. Melnichuk

    2018-04-01

    Full Text Available Network technology for interaction between two applications via the HTTP protocol was considered in article.When client works with REST API - it means it works with "resources", and in SOAP work is performed with operations. To build REST web services, you must follow certain principles: explicit use of HTTP methods, access to resources by URI, stateless, HATEAOS, caching, transfer of objects in JSON or XML representation. But sometimes some principles are ignored to ensure a higher speed of work and to reduce development time.The pros and cons of using JSON and XML representations were considered, and it can be said that using the JSON format reduces the amount of data transfer, and with the use of XML, the readability of data increases.Also, two main ways of data transfer in REST web services were considered: converting the file to Base64 and transferring it as an object field or transferring the file using the usual HTTP multipart. The Base64 standard approach gives a higher speed for multiple files in a single request, because only one HTTP connection is created, but these files are stored in RAM during request processing, which increases chance of the application crashing.In the conclusion, the advantages of using web services and their wide use in other architectural approaches were considered, which increases the popularity of web services.

  20. 'My wife, you are supposed to have a rest now': an analysis of norms influencing men's role in prenatal care in south-eastern Tanzania.

    Science.gov (United States)

    Gross, Karin; Mayumana, Iddy; Obrist, Brigit

    2013-04-01

    Men as sexual partners, fathers and household heads have a direct bearing on women's reproductive health. However, little is known about the influence of changing norms and values on men's role in ensuring women's health during pregnancy and childbirth. This study from rural south-eastern Tanzania explores men's and women's discussions on men's roles and responsibilities in prenatal care and links them to an analysis of norms and values at the household level and beyond. Data from eight focus group discussions with men and women were consensually coded and analysed using a qualitative content analysis. Four dimensions of norms and values, which emerged from analysis, bear upon men's support towards pregnant women: changing gender identities; changing family and marriage structures; biomedical values disseminated in health education; and government regulations. The findings suggest that Tanzanian men are exposed to a contradictory and changing landscape of norms and values in relation to maternal health.

  1. Impact of local and non-local sources of pollution on background US Ozone: synergy of a low-earth orbiting and geostationary sounder constellation

    Science.gov (United States)

    Bowman, K. W.; Lee, M.

    2015-12-01

    Dramatic changes in the global distribution of emissions over the last decade have fundamentally altered source-receptor pollution impacts. A new generation of low-earth orbiting (LEO) sounders complimented by geostationary sounders over North America, Europe, and Asia providing a unique opportunity to quantify the current and future trajectory of emissions and their impact on global pollution. We examine the potential of this constellation of air quality sounders to quantify the role of local and non-local sources of pollution on background ozone in the US. Based upon an adjoint sensitivity method, we quantify the role synoptic scale transport of non-US pollution on US background ozone over months representative of different source-receptor relationships. This analysis allows us distinguish emission trajectories from megacities, e.g. Beijing, or regions, e.g., western China, from natural trends on downwind ozone. We subsequently explore how a combination of LEO and GEO observations could help quantify the balance of local emissions against changes in distant sources . These results show how this unprecedented new international ozone observing system can monitor the changing structure of emissions and their impact on global pollution.

  2. Rest requirements and rest management of personnel in shift work

    Energy Technology Data Exchange (ETDEWEB)

    Hammell, B.D. [PDG Environmental, Melbourne, FL (United States); Scheuerle, A. [Univ. of Texas, Houston, TX (United States)

    1995-12-31

    A difficulty-weighted shift assignment scheme is proposed for use in prolonged and strenuous field operations such as emergency response, site testing, and short term hazardous waste remediation projects. The purpose of the work rotation plan is to increase productivity, safety, and moral of workers. Job weighting is accomplished by assigning adjustments to the mental and physical intensity of the task, the protective equipment worn, and the climatic conditions. The plan is based on medical studies of sleep deprivation, the effects of rest adjustments, and programs to reduce sleep deprivation and normalize shift schedules.

  3. Characteristics of Spatial Synchronization of Encephalograms in Left- and Right-Handed Subjects in Resting State and During Cognitive Testing: a Graph-Theory Analysis

    OpenAIRE

    Lukoyanov M.V.; Grechikhin I.S.; Kalyagin V.A.; Pardalos P.M.; Mukhina I.V.

    2014-01-01

    Hand preference is one of the most striking manifestations of functional brain asymmetry. However, the nature of the phenomenon, as well as its interaction with other brain functions has not been fully understood. Therefore, the study of brain peculiarities of left- and right-handed subjects by neuronal network analysis is of particular interest. The aim of the investigation was to analyze brain network structures according to electroencephalography findings in left- and right-handed subj...

  4. AgNOR Count in Resting Cells (Resting NOR Is a New Prognostic Marker in Invasive Bladder Tumor

    Directory of Open Access Journals (Sweden)

    Mitsuro Tomobe

    2001-01-01

    Full Text Available Purpose: We have previously demonstrated that the AgNOR count in proliferating cells is a predictor of tumor recurrence in superficial bladder tumor (J. Urol. 162 (1999, 63–68. In the present study, we evaluate the type of AgNOR associated with cell cycles as a prognostic factor in invasive bladder tumor using a double staining technique employing both AgNOR and MIB-1 labelling. Materials and methods: Forty-four paraffin sections of invasive bladder tumors were stained simultaneously with AgNOR and MIB-1. The number of AgNORs in proliferating (MIB-1 positive or resting (MIB-1 negative cells were counted from a total of 100 nuclei. Correlations between MIB-1 associated AgNOR count and clinicopathological parameters were statistically analyzed. Results: The AgNOR count in proliferating cells (proliferating NOR was significantly higher than that in resting cells (resting NOR (p < 0.01. The resting NOR in tumors with distant metastases was significantly higher than that in tumors without metastases (p < 0.05. Patients with a low resting NOR tumor had a better prognosis than those with a high resting NOR tumor, whereas the proliferating NOR was not associated with survival. Survival analysis revealed that the resting NOR was the most powerful prognostic marker in patients with invasive bladder tumor (p < 0.05. Conclusions: Resting NOR had a predictive value in the prognosis of patients with invasive bladder tumor. Keywords: Transitional cell carcinoma, invasive, resting cell, AgNORs, MIB-1

  5. Sustainable Rest Area Design and Operations

    Science.gov (United States)

    2017-10-01

    One way in which State Departments of Transportation (DOTs) can modernize their rest areas while reducing operations and maintenance costs is by incorporating sustainable practices into rest area design and operations. Sustainability practices that D...

  6. Regional cerebral blood flow as assessed by principal component analysis and 99mTc-HMPAO SPET in healthy subjects at rest: normal distribution and effect of age and gender

    International Nuclear Information System (INIS)

    Pagani, M.; Salmaso, D.; Jonsson, C.; Hatherly, R.; Larsson, S.A.; Jacobsson, H.; Waegner, A.

    2002-01-01

    The increasing implementation of standardisation techniques in brain research and clinical diagnosis has highlighted the importance of reliable baseline data from normal control subjects for inter-subject analysis. In this context, knowledge of the regional cerebral blood flow (rCBF) distribution in normal ageing is a factor of the utmost importance. In the present study, rCBF was investigated in 50 healthy volunteers (25 men, 25 women), aged 31-78 years, who were examined at rest by means of single-photon emission tomography (SPET) using technetium-99m d,l-hexamethylpropylene amine oxime (HMPAO). After normalising the CBF data, 27 left and 27 right volumes of interest (VOIs) were selected and automatically outlined by standardisation software (computerised brain atlas). The heavy load of flow data thus obtained was reduced in number and grouped in factors by means of principal component analysis (PCA). PCA extracted 12 components explaining 81% of the variance and including the vast majority of cortical and subcortical regions. Analysis of variance and regression analyses were performed for rCBF, age and gender before PCA was applied and subsequently for each single extracted factor. There was a significantly higher CBF on the right side than on the left side (P<0.001). In the overall analysis, a significant decrease was found in CBF (P=0.05) with increasing age, and this decrease was particularly evident in the left hemisphere (P=0.006). When gender was specifically analysed, CBF was found to decrease significantly with increasing age in females (P=0.037) but not in males. Furthermore, a significant decrease in rCBF with increasing age was found in the brain vertex (P=0.05), left frontotemporal cortex (P=0.012) and temporocingulate cortex (P=0.003). By contrast, relative rCBF in central structures increased with age (P=0.001). The ability of standardisation software and PCA to identify functionally connected brain regions might contribute to a better

  7. Regional cerebral blood flow as assessed by principal component analysis and {sup 99m}Tc-HMPAO SPET in healthy subjects at rest: normal distribution and effect of age and gender

    Energy Technology Data Exchange (ETDEWEB)

    Pagani, M. [Inst. of Neurobiology and Molecular Medicine, CNR, Rome (Italy); Dept. of Hospital Physics, Karolinska Hospital, Stockholm (Sweden); Salmaso, D. [Inst. of Psychology, CNR, Rome (Italy); Jonsson, C.; Hatherly, R.; Larsson, S.A. [Dept. of Hospital Physics, Karolinska Hospital, Stockholm (Sweden); Jacobsson, H. [Dept. of Diagnostic Radiology, Karolinska Hospital, Stockholm (Sweden); Waegner, A. [Dept. of Clinical Neuroscience, Karolinska Institutet, Stockholm (Sweden); Dept. of Clinical Neuroscience, Karolinska Hospital, Stockholm (Sweden)

    2002-01-01

    The increasing implementation of standardisation techniques in brain research and clinical diagnosis has highlighted the importance of reliable baseline data from normal control subjects for inter-subject analysis. In this context, knowledge of the regional cerebral blood flow (rCBF) distribution in normal ageing is a factor of the utmost importance. In the present study, rCBF was investigated in 50 healthy volunteers (25 men, 25 women), aged 31-78 years, who were examined at rest by means of single-photon emission tomography (SPET) using technetium-99m d,l-hexamethylpropylene amine oxime (HMPAO). After normalising the CBF data, 27 left and 27 right volumes of interest (VOIs) were selected and automatically outlined by standardisation software (computerised brain atlas). The heavy load of flow data thus obtained was reduced in number and grouped in factors by means of principal component analysis (PCA). PCA extracted 12 components explaining 81% of the variance and including the vast majority of cortical and subcortical regions. Analysis of variance and regression analyses were performed for rCBF, age and gender before PCA was applied and subsequently for each single extracted factor. There was a significantly higher CBF on the right side than on the left side (P<0.001). In the overall analysis, a significant decrease was found in CBF (P=0.05) with increasing age, and this decrease was particularly evident in the left hemisphere (P=0.006). When gender was specifically analysed, CBF was found to decrease significantly with increasing age in females (P=0.037) but not in males. Furthermore, a significant decrease in rCBF with increasing age was found in the brain vertex (P=0.05), left frontotemporal cortex (P=0.012) and temporocingulate cortex (P=0.003). By contrast, relative rCBF in central structures increased with age (P=0.001). The ability of standardisation software and PCA to identify functionally connected brain regions might contribute to a better

  8. Reconstruction of the diet of a pre hispanic population sector of Cuauhnahuac, Morelos by means of the chemical elements analysis in skeletal rests

    International Nuclear Information System (INIS)

    Brito, L.; Garza, I.; Banos, L.; Chaire, F.

    2004-01-01

    The goal of this work was diet reconstruction of 25 pre hispanic residents of Cuauhnahuac, tributary town of the mexicas, during the Late Pos classic period (1350-1521 a.C.). The analysis included human skull samples proceeding from human femur, tibia and fibula. The applied technique was X-ray fluorescence spectrometry (XRF) to know the mineral concentrations, which are closely related with the quality and quantity of the consumed food. The main indicative elements are strontium (Sr), that denotes the consumption of vegetables, zinc (Zn), that shows the consumption of animal proteins, and magnesium (Mg), associated with Meso american food resources. The results indicate the existence of differences in the diet among the same population's individuals, probably because social stratification determined the power resources acquisition. (Author) 28 refs., 7 tabs., 2 figs

  9. Restful API Architecture Based on Laravel Framework

    Science.gov (United States)

    Chen, Xianjun; Ji, Zhoupeng; Fan, Yu; Zhan, Yongsong

    2017-10-01

    Web service has been an industry standard tech for message communication and integration between heterogeneous systems. RESTFUL API has become mainstream web service development paradigm after SOAP, how to effectively construct RESTFUL API remains a research hotspots. This paper presents a development model of RESTFUL API construction based on PHP language and LARAVEL framework. The key technical problems that need to be solved during the construction of RESTFUL API are discussed, and implementation details based on LARAVEL are given.

  10. Non-local exchange correlation functionals impact on the structural, electronic and optical properties of III-V arsenides

    KAUST Repository

    Anua, N. Najwa

    2013-08-20

    Exchange correlation (XC) energy functionals play a vital role in the efficiency of density functional theory (DFT) calculations, more soundly in the calculation of fundamental electronic energy bandgap. In the present DFT study of III-arsenides, we investigate the implications of XC-energy functional and corresponding potential on the structural, electronic and optical properties of XAs (X = B, Al, Ga, In). Firstly we report and discuss the optimized structural lattice parameters and the band gap calculations performed within different non-local XC functionals as implemented in the DFT-packages: WIEN2k, CASTEP and SIESTA. These packages are representative of the available code in ab initio studies. We employed the LDA, GGA-PBE, GGA-WC and mBJ-LDA using WIEN2k. In CASTEP, we employed the hybrid functional, sX-LDA. Furthermore LDA, GGA-PBE and meta-GGA were employed using SIESTA code. Our results point to GGA-WC as a more appropriate approximation for the calculations of structural parameters. However our electronic bandstructure calculations at the level of mBJ-LDA potential show considerable improvements over the other XC functionals, even the sX-LDA hybrid functional. We report also the optical properties within mBJ potential, which show a nice agreement with the experimental measurements in addition to other theoretical results. © 2013 IOP Publishing Ltd.

  11. Improving Signal-to-Noise Ratio in Susceptibility Weighted Imaging: A Novel Multicomponent Non-Local Approach.

    Directory of Open Access Journals (Sweden)

    Pasquale Borrelli

    Full Text Available In susceptibility-weighted imaging (SWI, the high resolution required to obtain a proper contrast generation leads to a reduced signal-to-noise ratio (SNR. The application of a denoising filter to produce images with higher SNR and still preserve small structures from excessive blurring is therefore extremely desirable. However, as the distributions of magnitude and phase noise may introduce biases during image restoration, the application of a denoising filter is non-trivial. Taking advantage of the potential multispectral nature of MR images, a multicomponent approach using a Non-Local Means (MNLM denoising filter may perform better than a component-by-component image restoration method. Here we present a new MNLM-based method (Multicomponent-Imaginary-Real-SWI, hereafter MIR-SWI to produce SWI images with high SNR and improved conspicuity. Both qualitative and quantitative comparisons of MIR-SWI with the original SWI scheme and previously proposed SWI restoring pipelines showed that MIR-SWI fared consistently better than the other approaches. Noise removal with MIR-SWI also provided improvement in contrast-to-noise ratio (CNR and vessel conspicuity at higher factors of phase mask multiplications than the one suggested in the literature for SWI vessel imaging. We conclude that a proper handling of noise in the complex MR dataset may lead to improved image quality for SWI data.

  12. Quantum non-locality vs. quasi-local measurements in the conditions of the Aharonov-Bohm effect

    International Nuclear Information System (INIS)

    Gulian, Armen M

    2014-01-01

    Theoretical explanation of the Meissner effect involves proportionality between current density and vector potential, which has many deep consequences. As noticed by de Gennes, superconductors in a magnetic field 'find an equilibrium state where the sum of kinetic and magnetic energies is minimum' and this state 'corresponds to the expulsion of the magnetic field'. This statement still leaves an open question: from which source is the superconducting current acquiring its kinetic energy? A naïve answer, perhaps, is from the energy of the magnetic field. However, one can consider situations (Aharonov-Bohm effect), where the classical magnetic field is locally absent in the area occupied by the current. Experiments demonstrate that despite the local absence of the magnetic field, current is, nevertheless, building up. From what source is it acquiring its energy then? Locally, only a vector potential is present. How does the vector potential facilitate the formation of the current? Is the current formation a result of a truly non-local quantum action, or does the local action of the vector potential have experimental consequences? We discuss possible experiments with a hybrid normal-metal superconductor circuitry, which can clarify this puzzling situation. Experimental answers will be important for further developments.

  13. A Non-Local, Energy-Optimized Kernel: Recovering Second-Order Exchange and Beyond in Extended Systems

    Science.gov (United States)

    Bates, Jefferson; Laricchia, Savio; Ruzsinszky, Adrienn

    The Random Phase Approximation (RPA) is quickly becoming a standard method beyond semi-local Density Functional Theory that naturally incorporates weak interactions and eliminates self-interaction error. RPA is not perfect, however, and suffers from self-correlation error as well as an incorrect description of short-ranged correlation typically leading to underbinding. To improve upon RPA we introduce a short-ranged, exchange-like kernel that is one-electron self-correlation free for one and two electron systems in the high-density limit. By tuning the one free parameter in our model to recover an exact limit of the homogeneous electron gas correlation energy we obtain a non-local, energy-optimized kernel that reduces the errors of RPA for both homogeneous and inhomogeneous solids. To reduce the computational cost of the standard kernel-corrected RPA, we also implement RPA renormalized perturbation theory for extended systems, and demonstrate its capability to describe the dominant correlation effects with a low-order expansion in both metallic and non-metallic systems. Furthermore we stress that for norm-conserving implementations the accuracy of RPA and beyond RPA structural properties compared to experiment is inherently limited by the choice of pseudopotential. Current affiliation: King's College London.

  14. Atomic adsorption on pristine graphene along the Periodic Table of Elements - From PBE to non-local functionals

    Science.gov (United States)

    Pašti, Igor A.; Jovanović, Aleksandar; Dobrota, Ana S.; Mentus, Slavko V.; Johansson, Börje; Skorodumova, Natalia V.

    2018-04-01

    The understanding of atomic adsorption on graphene is of high importance for many advanced technologies. Here we present a complete database of the atomic adsorption energies for the elements of the Periodic Table up to the atomic number 86 (excluding lanthanides) on pristine graphene. The energies have been calculated using the projector augmented wave (PAW) method with PBE, long-range dispersion interaction corrected PBE (PBE+D2, PBE+D3) as well as non-local vdW-DF2 approach. The inclusion of dispersion interactions leads to an exothermic adsorption for all the investigated elements. Dispersion interactions are found to be of particular importance for the adsorption of low atomic weight earth alkaline metals, coinage and s-metals (11th and 12th groups), high atomic weight p-elements and noble gases. We discuss the observed adsorption trends along the groups and rows of the Periodic Table as well some computational aspects of modelling atomic adsorption on graphene.

  15. Phase structure of the Born-Infeld-anti-de Sitter black holes probed by non-local observables

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, Xiao-Xiong [Chongqing Jiaotong University, School of Material Science and Engineering, Chongqing (China); Chinese Academy of Sciences, Institute of Theoretical Physics, Beijing (China); Liu, Xian-Ming [Center for Theoretical Physics, Massachusetts Institute of Technology, Cambridge, MA (United States); Hubei University for Nationalities, Center for Theoretical Physics, School of Sciences, Enshi, Hubei (China); Li, Li-Fang [Chinese Academy of Sciences, State Key Laboratory of Space Weather, Center for Space Science and Applied Research, Beijing (China)

    2016-11-15

    With the non-local observables such as two point correlation function and holographic entanglement entropy, we probe the phase structure of the Born-Infeld-anti-de Sitter black holes. For the case bQ > 0.5, where b is the Born-Infeld parameter and Q is the charge of the black hole, the phase structure is found to be similar to that of the Van der Waals phase transition, namely the black hole undergoes a first order phase transition and a second order phase transition before it reaches a stable phase. While for the case bQ < 0.5, a new phase branch emerges besides the Van der Waals phase transition. For the first order phase transition, the equal area law is checked, and for the second order phase transition, the critical exponent of the heat capacity is obtained. All these results are found to be the same as that observed in the entropy-temperature plane. (orig.)

  16. First ERO2.0 modeling of Be erosion and non-local transport in JET ITER-like wall

    Science.gov (United States)

    Romazanov, J.; Borodin, D.; Kirschner, A.; Brezinsek, S.; Silburn, S.; Huber, A.; Huber, V.; Bufferand, H.; Firdaouss, M.; Brömmel, D.; Steinbusch, B.; Gibbon, P.; Lasa, A.; Borodkina, I.; Eksaeva, A.; Linsmeier, Ch; Contributors, JET

    2017-12-01

    ERO is a Monte-Carlo code for modeling plasma-wall interaction and 3D plasma impurity transport for applications in fusion research. The code has undergone a significant upgrade (ERO2.0) which allows increasing the simulation volume in order to cover the entire plasma edge of a fusion device, allowing a more self-consistent treatment of impurity transport and comparison with a larger number and variety of experimental diagnostics. In this contribution, the physics-relevant technical innovations of the new code version are described and discussed. The new capabilities of the code are demonstrated by modeling of beryllium (Be) erosion of the main wall during JET limiter discharges. Results for erosion patterns along the limiter surfaces and global Be transport including incident particle distributions are presented. A novel synthetic diagnostic, which mimics experimental wide-angle 2D camera images, is presented and used for validating various aspects of the code, including erosion, magnetic shadowing, non-local impurity transport, and light emission simulation.

  17. Image inpainting and super-resolution using non-local recursive deep convolutional network with skip connections

    Science.gov (United States)

    Liu, Miaofeng

    2017-07-01

    In recent years, deep convolutional neural networks come into use in image inpainting and super-resolution in many fields. Distinct to most of the former methods requiring to know beforehand the local information for corrupted pixels, we propose a 20-depth fully convolutional network to learn an end-to-end mapping a dataset of damaged/ground truth subimage pairs realizing non-local blind inpainting and super-resolution. As there often exist image with huge corruptions or inpainting on a low-resolution image that the existing approaches unable to perform well, we also share parameters in local area of layers to achieve spatial recursion and enlarge the receptive field. To avoid the difficulty of training this deep neural network, skip-connections between symmetric convolutional layers are designed. Experimental results shows that the proposed method outperforms state-of-the-art methods for diverse corrupting and low-resolution conditions, it works excellently when realizing super-resolution and image inpainting simultaneously

  18. Analytical solution for static and dynamic analysis of magnetically affected viscoelastic orthotropic double-layered graphene sheets resting on viscoelastic foundation

    Science.gov (United States)

    Jalaei, M. H.; Arani, A. Ghorbanpour

    2018-02-01

    By considering the small scale effect based on the nonlocal Eringen's theory, the static and dynamic analysis of viscoelastic orthotropic double-layered graphene sheets subjected to longitudinal magnetic field and mechanical load is investigated analytically. For this objective, first order shear deformation theory (FSDT) is proposed. The surrounding medium is simulated by visco-Pasternak foundation model in which damping, normal and transverse shear loads are taken into account. The governing equations of motion are obtained via energy method and Hamilton's principle which are then solved analytically by means of Navier's approach and Laplace inversion technique in the space and time domains, respectively. Through various parametric studies, the influences of the nonlocal parameter, structural damping, van der Waals (vdW) interaction, stiffness and damping coefficient of the foundation, magnetic parameter, aspect ratio and length to thickness ratio on the static and dynamic response of the nanoplates are examined. The results depict that when the vdW interaction is considered to be zero, the upper layer deflection reaches a maximum point whereas the lower layer deflection becomes zero. In addition, it is observed that with growing the vdW interaction, the effect of magnetic field on the deflection of the lower layer increases while this effect reduces for the upper layer deflection.

  19. Three-body models of the 6ΛΛHe and 9ΛBe hypernuclei with non-local interactions

    International Nuclear Information System (INIS)

    Theeten, M.; Baye, D.; Descouvemont, P.

    2005-01-01

    A three-body model involving non-local interactions is developed in configuration space. It is based on a hyperspherical-harmonics expansion and the Lagrange-mesh method. The 6 ΛΛ He and 9 Λ Be hypernuclei are studied as three-body αΛΛ and ααΛ systems. Recently proposed quark-model based ΛN and ΛΛ interactions are used. A non-local Λα interaction is obtained by folding the ΛN interaction with a Gaussian α density. Various phenomenological αα interactions are employed. The results agree within 1 keV with recent Faddeev calculations in momentum space. Energies and radii of 6 ΛΛ He and 9 Λ Be are compared with a purely local model. The B(E2) between the 9 Λ Be bound states is also calculated. The role of non-locality is discussed

  20. Rest but busy: Aberrant resting-state functional connectivity of triple network model in insomnia.

    Science.gov (United States)

    Dong, Xiaojuan; Qin, Haixia; Wu, Taoyu; Hu, Hua; Liao, Keren; Cheng, Fei; Gao, Dong; Lei, Xu

    2018-02-01

    One classical hypothesis among many models to explain the etiology and maintenance of insomnia disorder (ID) is hyperarousal. Aberrant functional connectivity among resting-state large-scale brain networks may be the underlying neurological mechanisms of this hypothesis. The aim of current study was to investigate the functional network connectivity (FNC) among large-scale brain networks in patients with insomnia disorder (ID) during resting state. In the present study, the resting-state fMRI was used to evaluate whether patients with ID showed aberrant FNC among dorsal attention network (DAN), frontoparietal control network (FPC), anterior default mode network (aDMN), and posterior default mode network (pDMN) compared with healthy good sleepers (HGSs). The Pearson's correlation analysis was employed to explore whether the abnormal FNC observed in patients with ID was associated with sleep parameters, cognitive and emotional scores, and behavioral performance assessed by questionnaires and tasks. Patients with ID had worse subjective thought control ability measured by Thought Control Ability Questionnaire (TCAQ) and more negative affect than HGSs. Intriguingly, relative to HGSs, patients with ID showed a significant increase in FNC between DAN and FPC, but a significant decrease in FNC between aDMN and pDMN. Exploratory analysis in patients with ID revealed a significantly positive correlation between the DAN-FPC FNC and reaction time (RT) of psychomotor vigilance task (PVT). The current study demonstrated that even during the resting state, the task-activated and task-deactivated large-scale brain networks in insomniacs may still maintain a hyperarousal state, looking quite similar to the pattern in a task condition with external stimuli. Those results support the hyperarousal model of insomnia.

  1. Prediction of left ventricular ejection fraction in patients with coronary artery disease based on an analysis of perfusion patterns at rest. Assessment by an artificial neural network

    International Nuclear Information System (INIS)

    Stefaniak, B.; Cholewinski, W.; Tarkowska, A.

    2004-01-01

    In CAD, left ventricular function depends on the condition of myocardial perfusion, hence it may be presumed that blood flow abnormalities may enable the LVEF to be predicted. The aim of the study was to apply an Artificial Neural Network (ANN) to investigate the relationships between myocardial perfusion and LVEF, measured simultaneously. gSPECT examinations were performed in 95 patients with CAD, divided into training (n = 50) and testing (n = 45) groups. using the acquired data, in each subject the LVEF was calculated and a perfusion polar map was constructed and divided into 25 segments. Based on results obtained in the training group, a characteristic configuration of segments was defined, with features enabling differentiation between the individual subjects of that group. The set of those segments, as well as the corresponding LVEF values enabled the optimum network architecture to be constructed and trained. The trained ANN was verified by application to the testing group. Using the above-described procedure, 15 polar map segments were defined which enabled the patients of the training group to be differentiated sufficiently enough to make their further recognition possible. The optimal network structure consisting 25 neurons was obtained by comparing the activity in those segments in individual subjects with corresponding LVEF values. Based on the above model, the obtained network was able to reproduce learning data (r = 0.832; learning error 4.84%) and to apply the gained knowledge to the testing cases (r = 0.786; testing error = 4.99%). The obtained network can generalise learned information. To predict LVEF, some polar map segments should be excluded from the analysis. Erroneous LVEF prediction may occur resulting mainly from conditions independent from perfusion abnormalities. (author)

  2. Discovering EEG resting state alterations of semantic dementia.

    Science.gov (United States)

    Grieder, Matthias; Koenig, Thomas; Kinoshita, Toshihiko; Utsunomiya, Keita; Wahlund, Lars-Olof; Dierks, Thomas; Nishida, Keiichiro

    2016-05-01

    Diagnosis of semantic dementia relies on cost-intensive MRI or PET, although resting EEG markers of other dementias have been reported. Yet the view still holds that resting EEG in patients with semantic dementia is normal. However, studies using increasingly sophisticated EEG analysis methods have demonstrated that slightest alterations of functional brain states can be detected. We analyzed the common four resting EEG microstates (A, B, C, and D) of 8 patients with semantic dementia in comparison with 8 healthy controls and 8 patients with Alzheimer's disease. Topographical differences between the groups were found in microstate classes B and C, while microstate classes A and D were comparable. The data showed that the semantic dementia group had a peculiar microstate E, but the commonly found microstate C was lacking. Furthermore, the presence of microstate E was significantly correlated with lower MMSE and language scores. Alterations in resting EEG can be found in semantic dementia. Topographical shifts in microstate C might be related to semantic memory deficits. This is the first study that discovered resting state EEG abnormality in semantic dementia. The notion that resting EEG in this dementia subtype is normal has to be revised. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  3. Large-N limit of the non-local 2D Yang-Mills and generalized Yang-Mills theories on a cylinder

    Energy Technology Data Exchange (ETDEWEB)

    Saaidi, K. [Department of Physics, Tehran University (Iran); Khorrami, M. [Institute for Advanced Studies in Basic Sciences, Zanjan (Iran)

    2002-04-01

    The large-group behavior of the non-local YM{sub 2}'s and gYM{sub 2}'s on a cylinder or a disk is investigated. It is shown that this behavior is similar to that of the corresponding local theory, but with the area of the cylinder replaced by an effective area depending on the dominant representation. The critical areas for non-local YM{sub 2}'s on a cylinder with some special boundary conditions are also obtained. (orig.)

  4. Non-local coupled-channels optical calculation of electron scattering by atomic hydrogen at 54.42 eV

    International Nuclear Information System (INIS)

    Ratnavelu, K.; McCarthy, I.E.

    1990-01-01

    The present study incorporates the non-local optical potentials for the continuum within the coupled-channels optical framework to study electron scattering from atomic hydrogen at 54.42 eV. Nine-state coupled-channels calculations with non-local and local continuum optical potentials were performed. The results for differential, total and ionization cross sections as well as the 2p angular correlation parameters λ and R are comparable with other non-perturbative calculations. There are still discrepancies between theory and experiment, particularly for λ and R at larger angles. (author)

  5. Resting State Network Estimation in Individual Subjects

    Science.gov (United States)

    Hacker, Carl D.; Laumann, Timothy O.; Szrama, Nicholas P.; Baldassarre, Antonello; Snyder, Abraham Z.

    2014-01-01

    Resting-state functional magnetic resonance imaging (fMRI) has been used to study brain networks associated with both normal and pathological cognitive function. The objective of this work is to reliably compute resting state network (RSN) topography in single participants. We trained a supervised classifier (multi-layer perceptron; MLP) to associate blood oxygen level dependent (BOLD) correlation maps corresponding to pre-defined seeds with specific RSN identities. Hard classification of maps obtained from a priori seeds was highly reliable across new participants. Interestingly, continuous estimates of RSN membership retained substantial residual error. This result is consistent with the view that RSNs are hierarchically organized, and therefore not fully separable into spatially independent components. After training on a priori seed-based maps, we propagated voxel-wise correlation maps through the MLP to produce estimates of RSN membership throughout the brain. The MLP generated RSN topography estimates in individuals consistent with previous studies, even in brain regions not represented in the training data. This method could be used in future studies to relate RSN topography to other measures of functional brain organization (e.g., task-evoked responses, stimulation mapping, and deficits associated with lesions) in individuals. The multi-layer perceptron was directly compared to two alternative voxel classification procedures, specifically, dual regression and linear discriminant analysis; the perceptron generated more spatially specific RSN maps than either alternative. PMID:23735260

  6. Human activity and rest in situ.

    Science.gov (United States)

    Roenneberg, Till; Keller, Lena K; Fischer, Dorothee; Matera, Joana L; Vetter, Céline; Winnebeck, Eva C

    2015-01-01

    Our lives are structured by the daily alternation of activity and rest, of wake and sleep. Despite significant advances in circadian and sleep research, we still lack answers to many of the most fundamental questions about this conspicuous behavioral pattern. We strongly believe that investigating this pattern in entrained conditions, real-life and daily contexts-in situ-will help the field to elucidate some of these central questions. Here, we present two common approaches for in situ investigation of human activity and rest: the Munich ChronoType Questionnaire (MCTQ) and actimetry. In the first half of this chapter, we provide detailed instructions on how to use and interpret the MCTQ. In addition, we give an overview of the main insights gained with this instrument over the past 10 years, including some new findings on the interaction of light and age on sleep timing. In the second half of this chapter, we introduce the reader to the method of actimetry and share our experience in basic analysis techniques, including visualization, smoothing, and cosine model fitting of in situ recorded data. Additionally, we describe our new approach to automatically detect sleep from activity recordings. Our vision is that the broad use of such easy techniques in real-life settings combined with automated analyses will lead to the creation of large databases. The resulting power of big numbers will promote our understanding of such fundamental biological phenomena as sleep. © 2015 Elsevier Inc. All rights reserved.

  7. What goes on in the resting-state? A qualitative glimpse into resting-state experience in the scanner

    Science.gov (United States)

    Hurlburt, Russell T.; Alderson-Day, Ben; Fernyhough, Charles; Kühn, Simone

    2015-01-01

    The brain’s resting-state has attracted considerable interest in recent years, but currently little is known either about typical experience during the resting-state or about whether there are inter-individual differences in resting-state phenomenology. We used descriptive experience sampling (DES) in an attempt to apprehend high fidelity glimpses of the inner experience of five participants in an extended fMRI study. Results showed that the inner experiences and the neural activation patterns (as quantified by amplitude of low frequency fluctuations analysis) of the five participants were largely consistent across time, suggesting that our extended-duration scanner sessions were broadly similar to typical resting-state sessions. However, there were very large individual differences in inner phenomena, suggesting that the resting-state itself may differ substantially from one participant to the next. We describe these individual differences in experiential characteristics and display some typical moments of resting-state experience. We also show that retrospective characterizations of phenomena can often be very different from moment-by-moment reports. We discuss implications for the assessment of inner experience in neuroimaging studies more generally, concluding that it may be possible to use fMRI to investigate neural correlates of phenomena apprehended in high fidelity. PMID:26500590

  8. Phase-correcting non-local means filtering for diffusion-weighted imaging of the spinal cord.

    Science.gov (United States)

    Kafali, Sevgi Gokce; Çukur, Tolga; Saritas, Emine Ulku

    2018-02-09

    DWI suffers from low SNR when compared to anatomical MRI. To maintain reasonable SNR at relatively high spatial resolution, multiple acquisitions must be averaged. However, subject motion or involuntary physiological motion during diffusion-sensitizing gradients cause phase offsets among acquisitions. When the motion is localized to a small region, these phase offsets become particularly problematic. Complex averaging of acquisitions lead to cancellations from these phase offsets, whereas magnitude averaging results in noise amplification. Here, we propose an improved reconstruction for multi-acquisition DWI that effectively corrects for phase offsets while reducing noise. Each acquisition is processed with a refocusing reconstruction for global phase correction and a partial k-space reconstruction via projection-onto-convex-sets (POCS). The proposed reconstruction then embodies a new phase-correcting non-local means (PC-NLM) filter. PC-NLM is performed on the complex-valued outputs of the POCS algorithm aggregated across acquisitions. The PC-NLM filter leverages the shared structure among multiple acquisitions to simultaneously alleviate nuisance factors including phase offsets and noise. Extensive simulations and in vivo DWI experiments of the cervical spinal cord are presented. The results demonstrate that the proposed reconstruction improves image quality by mitigating signal loss because of phase offsets and reducing noise. Importantly, these improvements are achieved while preserving the accuracy of apparent diffusion coefficient maps. An improved reconstruction incorporating a PC-NLM filter for multi-acquisition DWI is presented. This reconstruction can be particularly beneficial for high-resolution or high-b-value DWI acquisitions that suffer from low SNR and phase offsets from local motion. © 2018 International Society for Magnetic Resonance in Medicine.

  9. Intrasellar Symptomatic Salivary Gland Rest

    Directory of Open Access Journals (Sweden)

    Chih-Hao Chen

    2007-05-01

    Full Text Available Ectopic salivary gland tissue in sellar turcica is frequently observed in microscopic examination at autopsy. This tissue is considered clinically silent. Only 2 symptomatic cases have been previously reported. Here we report a 28-year-old woman presenting with galactorrhea and hyperprolactinemia. Magnetic resonance imaging revealed a 6×5-mm nodule in the posterior aspect of the pituitary gland. This nodule showed isointensity on T1- and T2-weighted images and less enhancement on post-contrast T1-weighted images. Transsphenoidal exploration revealed a cystic lesion within the pituitary gland, which consisted of a grayish gelatinous content. The pathologic examination confirmed the diagnosis of salivary gland rest.

  10. Same day injections of Tc-99m methoxy isobutyl isonitrile (hexamibi) for myocardial tomographic imaging: Comparison between rest-stress and stress-rest injection sequences

    International Nuclear Information System (INIS)

    Taillefer, R.; Gagnon, A.; Laflamme, L.; Leveille, J.; Phaneuf, D.C.

    1989-01-01

    It has been shown that both rest and stress 99m Tc-hexamibi myocardial perfusion imaging can be performed on the same day using two different doses injected within few h (the first one at rest followed by a second at stress). In order to evaluate and compare 2 sequences (rest-stress and stress-rest) of 99m Tc-hexamibi injections performed the same day, 18 patients with either abnormal 201 Tl myocardial scan or abnormal coronary angiography were studied with 2 99m Tc-hexamibi injections protocols. The rest-stress study was performed as follows: 7 mCi 99m Tc-hexamibi was injected at rest. Single photon emission computed tomography (SPECT) was performed 60 min later. Immediately after the rest study, patients were injected at peak stress with 25 mCi 99m Tc-hexamibi. Tomographic imaging was repeated 1 h later. Patients were submitted to the stress-rest protocol within 3 days. Tomographic imaging was done 1 h after a 7 mCi injection at stress. This study was followed by an injection of 25 mCi 99m Tc-hexamibi at rest, a tomographic study was performed 60 min later. Myocardial sections were reconstructed in horizontal long, vertical long, and short axes. Data analysis also included polar map representation. A total of 324 segments were interpreted blind by 3 observers, there was an agreement in 283/324 (87.3%) segments between the 2 protocols. However, 24 segments (7.4%) judged ischemic on rest-stress were called scars on stress-rest. In three patients, myocardial segments were judged normal on the rest image of the rest-stress protocol while they were found abnormal (false positive images) on the stress-rest sequence. Stress images from both protocols were judged similar in 17 patients. In conclusion, when using a short time interval (less than 2 h) between two 99m Tc-hexamibi injections, it is preferable to do a rest-stress sequence since the rest image performed initially represents a true rest study, which is not necessarily the case with the stress-rest sequence

  11. Experimental benchmark of non-local-thermodynamic-equilibrium plasma atomic physics codes; Validation experimentale des codes de physique atomique des plasmas hors equilibre thermodynamique local

    Energy Technology Data Exchange (ETDEWEB)

    Nagels-Silvert, V

    2004-09-15

    The main purpose of this thesis is to get experimental data for the testing and validation of atomic physics codes dealing with non-local-thermodynamical-equilibrium plasmas. The first part is dedicated to the spectroscopic study of xenon and krypton plasmas that have been produced by a nanosecond laser pulse interacting with a gas jet. A Thomson scattering diagnostic has allowed us to measure independently plasma parameters such as electron temperature, electron density and the average ionisation state. We have obtained time integrated spectra in the range between 5 and 10 angstroms. We have identified about one hundred xenon rays between 8.6 and 9.6 angstroms via the use of the Relac code. We have discovered unknown rays for the krypton between 5.2 and 7.5 angstroms. In a second experiment we have extended the wavelength range to the X UV domain. The Averroes/Transpec code has been tested in the ranges from 9 to 15 angstroms and from 10 to 130 angstroms, the first range has been well reproduced while the second range requires a more complex data analysis. The second part is dedicated to the spectroscopic study of aluminium, selenium and samarium plasmas in femtosecond operating rate. We have designed an interferometry diagnostic in the frequency domain that has allowed us to measure the expanding speed of the target's backside. Via the use of an adequate isothermal model this parameter has led us to know the plasma electron temperature. Spectra and emission times of various rays from the aluminium and selenium plasmas have been computed satisfactorily with the Averroes/Transpec code coupled with Film and Multif hydrodynamical codes. (A.C.)

  12. Experimental benchmark of non-local-thermodynamic-equilibrium plasma atomic physics codes; Validation experimentale des codes de physique atomique des plasmas hors equilibre thermodynamique local

    Energy Technology Data Exchange (ETDEWEB)

    Nagels-Silvert, V

    2004-09-15

    The main purpose of this thesis is to get experimental data for the testing and validation of atomic physics codes dealing with non-local-thermodynamical-equilibrium plasmas. The first part is dedicated to the spectroscopic study of xenon and krypton plasmas that have been produced by a nanosecond laser pulse interacting with a gas jet. A Thomson scattering diagnostic has allowed us to measure independently plasma parameters such as electron temperature, electron density and the average ionisation state. We have obtained time integrated spectra in the range between 5 and 10 angstroms. We have identified about one hundred xenon rays between 8.6 and 9.6 angstroms via the use of the Relac code. We have discovered unknown rays for the krypton between 5.2 and 7.5 angstroms. In a second experiment we have extended the wavelength range to the X UV domain. The Averroes/Transpec code has been tested in the ranges from 9 to 15 angstroms and from 10 to 130 angstroms, the first range has been well reproduced while the second range requires a more complex data analysis. The second part is dedicated to the spectroscopic study of aluminium, selenium and samarium plasmas in femtosecond operating rate. We have designed an interferometry diagnostic in the frequency domain that has allowed us to measure the expanding speed of the target's backside. Via the use of an adequate isothermal model this parameter has led us to know the plasma electron temperature. Spectra and emission times of various rays from the aluminium and selenium plasmas have been computed satisfactorily with the Averroes/Transpec code coupled with Film and Multif hydrodynamical codes. (A.C.)

  13. A non-local thermodynamical equilibrium line formation for neutral and singly ionized titanium in model atmospheres of reference A-K stars

    Science.gov (United States)

    Sitnova, T. M.; Mashonkina, L. I.; Ryabchikova, T. A.

    2016-09-01

    We construct a model atom for Ti I-II using more than 3600 measured and predicted energy levels of Ti I and 1800 energy levels of Ti II, and quantum mechanical photoionization cross-sections. Non-local thermodynamical equilibrium (NLTE) line formation for Ti I and Ti II is treated through a wide range of spectral types from A to K, including metal-poor stars with [Fe/H] down to -2.6 dex. NLTE leads to weakened Ti I lines and positive abundance corrections. The magnitude of NLTE corrections is smaller compared to the literature data for FGK atmospheres. NLTE leads to strengthened Ti II lines and negative NLTE abundance corrections. For the first time, we have performed NLTE calculations for Ti I-II in the 6500 ≤ Teff ≤ 13 000 K range. For four A-type stars, we derived in LTE an abundance discrepancy of up to 0.22 dex between Ti I and Ti II, which vanishes in NLTE. For four other A-B stars, with only Ti II lines observed, NLTE leads to a decrease of line-to-line scatter. An efficiency of inelastic Ti I + H I collisions was estimated from an analysis of Ti I and Ti II lines in 17 cool stars with -2.6 ≤ [Fe/H] ≤ 0.0. Consistent NLTE abundances from Ti I and Ti II were obtained by applying classical Drawinian rates for the stars with log g ≥ 4.1, and neglecting inelastic collisions with H I for the very metal-poor (VMP) giant HD 122563. For the VMP turn-off stars ([Fe/H] ≤ -2 and log g ≤ 4.1), we obtained the positive abundance difference Ti I-II already in LTE, which increases in NLTE. Accurate collisional data for Ti I and Ti II are necessary to help solve this problem.

  14. Quantum non-local charges and absence of particle production in the two-dimensional non-linear sigma-model

    International Nuclear Information System (INIS)

    Luescher, M.

    1977-12-01

    Conserved non-local charges are shown to exist in the quantum non-linear sigma-model by a non-perturbative method. They imply the absence of particle production and the 'factorization equations' for the two particle S-matrix, which can then be calculated explicitly. (Auth.)

  15. Non-local thermodynamic equilibrium stellar spectroscopy with 1D and 3D models - II. Chemical properties of the Galactic metal-poor disk and the halo

    DEFF Research Database (Denmark)

    Bergemann, Maria; Collet, Remo; Schönrich, Ralph

    2016-01-01

    We have analysed high-resolution spectra of 328 stars and derived Mg abundances using non-local thermodynamic equilibrium (NLTE) spectral line formation calculations and plane-parallel model stellar atmospheres derived from the mean stratification of 3D hydrodynamical surface convection simulations...

  16. Modifications of resting state networks in spinocerebellar ataxia type 2.

    Science.gov (United States)

    Cocozza, Sirio; Saccà, Francesco; Cervo, Amedeo; Marsili, Angela; Russo, Cinzia Valeria; Giorgio, Sara Maria Delle Acque; De Michele, Giuseppe; Filla, Alessandro; Brunetti, Arturo; Quarantelli, Mario

    2015-09-01

    We aimed to investigate the integrity of the Resting State Networks in spinocerebellar ataxia type 2 (SCA2) and the correlations between the modification of these networks and clinical variables. Resting-state functional magnetic resonance imaging (RS-fMRI) data from 19 SCA2 patients and 29 healthy controls were analyzed using an independent component analysis and dual regression, controlling at voxel level for the effect of atrophy by co-varying for gray matter volume. Correlations between the resting state networks alterations and disease duration, age at onset, number of triplets, and clinical score were assessed by Spearman's coefficient, for each cluster which was significantly different in SCA2 patients compared with healthy controls. In SCA2 patients, disruption of the cerebellar components of all major resting state networks was present, with supratentorial involvement only for the default mode network. When controlling at voxel level for gray matter volume, the reduction in functional connectivity in supratentorial regions of the default mode network, and in cerebellar regions within the default mode, executive and right fronto-parietal networks, was still significant. No correlations with clinical variables were found for any of the investigated resting state networks. The SCA2 patients show significant alterations of the resting state networks, only partly explained by the atrophy. The default mode network is the only resting state network that shows also supratentorial changes, which appear unrelated to the cortical gray matter volume. Further studies are needed to assess the clinical significance of these changes. © 2015 International Parkinson and Movement Disorder Society.

  17. MO-DE-207A-11: Sparse-View CT Reconstruction Via a Novel Non-Local Means Method

    International Nuclear Information System (INIS)

    Chen, Z; Qi, H; Wu, S; Xu, Y; Zhou, L

    2016-01-01

    Purpose: Sparse-view computed tomography (CT) reconstruction is an effective strategy to reduce the radiation dose delivered to patients. Due to its insufficiency of measurements, traditional non-local means (NLM) based reconstruction methods often lead to over-smoothness in image edges. To address this problem, an adaptive NLM reconstruction method based on rotational invariance (RIANLM) is proposed. Methods: The method consists of four steps: 1) Initializing parameters; 2) Algebraic reconstruction technique (ART) reconstruction using raw projection data; 3) Positivity constraint of the image reconstructed by ART; 4) Update reconstructed image by using RIANLM filtering. In RIANLM, a novel similarity metric that is rotational invariance is proposed and used to calculate the distance between two patches. In this way, any patch with similar structure but different orientation to the reference patch would win a relatively large weight to avoid over-smoothed image. Moreover, the parameter h in RIANLM which controls the decay of the weights is adaptive to avoid over-smoothness, while it in NLM is not adaptive during the whole reconstruction process. The proposed method is named as ART-RIANLM and validated on Shepp-Logan phantom and clinical projection data. Results: In our experiments, the searching neighborhood size is set to 15 by 15 and the similarity window is set to 3 by 3. For the simulated case with a resolution of 256 by 256 Shepp-Logan phantom, the ART-RIANLM produces higher SNR (35.38dB<24.00dB) and lower MAE (0.0006<0.0023) reconstructed image than ART-NLM. The visual inspection demonstrated that the proposed method could suppress artifacts or noises more effectively and preserve image edges better. Similar results were found for clinical data case. Conclusion: A novel ART-RIANLM method for sparse-view CT reconstruction is presented with superior image. Compared to the conventional ART-NLM method, the SNR and MAE from ART-RIANLM increases 47% and decreases 74

  18. Pro REST API development with nodejs

    CERN Document Server

    Doglio, Fernando

    2015-01-01

    Pro REST API Development with Node.js is your guide to managing and understanding the full capabilities of successful REST development. API design is a hot topic in the programming world, but not many resources exist for developers to really understand how you can leverage the advantages. This book will provide a brief background on REST and the tools it provides (well known and not so well known). Understand how there is more to REST than just JSON and URLs. You will then cover and compare the maintained modules currently available in the npm community, including Express, Restify, Vatican,

  19. Isospin effects in anti p3He annihilation at rest

    International Nuclear Information System (INIS)

    Balestra, F.; Barbieri, R.; Batusov, Yu.A.; Bendiscioli, G.; Breivik, F.O.; Bossolasco, S.; Bussa, M.P.; Busso, L.; Falomkin, I.V.; Ferrero, L.; Guaraldo, C.; Haatuft, A.; Halsteinslid, A.; Jacobsen, T.; Lodi Rizzini, E.; Maggiora, A.; Myklebost, K.; Olsen, J.M.; Panzieri, D.; Piragino, G.; Pontecorvo, G.B.; Rozhdestvensky, A.M.; Rotondi, A.; Salvini, P.; Sapozhnikov, M.G.; Soerensen, S.O.; Tosello, F.; Tretyak, V.I.; Venaglioni, A.; Zenoni, A.

    1989-01-01

    The analysis of anti p 3 He annihilation events at rest (from the PS 179 experiment at LEAR) gives the value 0.467±0.035 for the ratio between the annihilation cross sections on n and on p. This low value indicates a strong isospin dependence of the anti NN amplitude in P wave. (orig.)

  20. Effects of aging on blood pressure variability in resting conditions

    NARCIS (Netherlands)

    Veerman, D. P.; Imholz, B. P.; Wieling, W.; Karemaker, J. M.; van Montfrans, G. A.

    1994-01-01

    The objective of this study was to determine the effect of aging on beat-to-beat blood pressure and pulse interval variability in resting conditions and to determine the effect of aging on the sympathetic and vagal influence on the cardiovascular system by power spectral analysis of blood pressure

  1. Resting state FMRI research in child psychiatric disorders

    NARCIS (Netherlands)

    Oldehinkel, Marianne; Francx, Winke; Beckmann, Christian; Buitelaar, Jan K.; Mennes, Maarten

    2013-01-01

    Concurring with the shift from linking functions to specific brain areas towards studying network integration, resting state FMRI (R-FMRI) has become an important tool for delineating the functional network architecture of the brain. Fueled by straightforward data collection, R-FMRI analysis methods

  2. Effects of strict prolonged bed rest on cardiorespiratory fitness

    DEFF Research Database (Denmark)

    Ried-Larsen, Mathias; Aarts, Hugo M; Joyner, Michael J

    2017-01-01

    The aim of this systematic review and meta-analysis [International Prospective Register of Systematic Reviews (PROSPERO) CRD42017055619] was to assess the effects of strict prolonged bed rest (without countermeasures) on maximal oxygen uptake (V̇o2max) and to explore sources of variation therein....

  3. Resting state brain networks in the prairie vole.

    Science.gov (United States)

    Ortiz, Juan J; Portillo, Wendy; Paredes, Raul G; Young, Larry J; Alcauter, Sarael

    2018-01-19

    Resting state functional magnetic resonance imaging (rsfMRI) has shown the hierarchical organization of the human brain into large-scale complex networks, referred as resting state networks. This technique has turned into a promising translational research tool after the finding of similar resting state networks in non-human primates, rodents and other animal models of great value for neuroscience. Here, we demonstrate and characterize the presence of resting states networks in Microtus ochrogaster, the prairie vole, an extraordinary animal model to study complex human-like social behavior, with potential implications for the research of normal social development, addiction and neuropsychiatric disorders. Independent component analysis of rsfMRI data from isoflurane-anestethized prairie voles resulted in cortical and subcortical networks, including primary motor and sensory networks, but also included putative salience and default mode networks. We further discuss how future research could help to close the gap between the properties of the large scale functional organization and the underlying neurobiology of several aspects of social cognition. These results contribute to the evidence of preserved resting state brain networks across species and provide the foundations to explore the use of rsfMRI in the prairie vole for basic and translational research.

  4. Predictive value of casual ECG-based resting heart rate compared with resting heart rate obtained from Holter recording

    DEFF Research Database (Denmark)

    Carlson, Nicholas; Dixen, Ulrik; Marott, Jacob L

    2014-01-01

    BACKGROUND: Elevated resting heart rate (RHR) is associated with cardiovascular mortality and morbidity. Assessment of heart rate (HR) from Holter recording may afford a more precise estimate of the effect of RHR on cardiovascular risk, as compared to casual RHR. Comparative analysis was carried ...

  5. The Effects of Long Duration Bed Rest as a Spaceflight Analogue on Resting State Sensorimotor Network Functional Connectivity and Neurocognitive Performance

    Science.gov (United States)

    Cassady, K.; Koppelmans, V.; Yuan, P.; Cooke, K.; De Dios, Y.; Stepanyan, V.; Szecsy, D.; Gadd, N.; Wood, S.; Reuter-Lorenz, P.; hide

    2015-01-01

    Long duration spaceflight has been associated with detrimental alterations in human sensorimotor systems and neurocognitive performance. Prolonged exposure to a head-down tilt position during long duration bed rest can resemble several effects of the microgravity environment such as reduced sensory inputs, body unloading and increased cephalic fluid distribution. The question of whether microgravity affects other central nervous system functions such as brain functional connectivity and its relationship with neurocognitive performance is largely unknown, but of potential importance to the health and performance of astronauts both during and post-flight. The aims of the present study are 1) to identify changes in sensorimotor resting state functional connectivity that occur with extended bed rest exposure, and to characterize their recovery time course; 2) to evaluate how these neural changes correlate with neurocognitive performance. Resting-state functional magnetic resonance imaging (rsfMRI) data were collected from 17 male participants. The data were acquired through the NASA bed rest facility, located at the University of Texas Medical Branch (Galveston, TX). Participants remained in bed with their heads tilted down six degrees below their feet for 70 consecutive days. RsfMRI data were obtained at seven time points: 7 and 12 days before bed rest; 7, 50, and 65 days during bed rest; and 7 and 12 days after bed rest. Functional connectivity magnetic resonance imaging (fcMRI) analysis was performed to measure the connectivity of sensorimotor networks in the brain before, during, and post-bed rest. We found a decrease in left putamen connectivity with the pre- and post-central gyri from pre bed rest to the last day in bed rest. In addition, vestibular cortex connectivity with the posterior cingulate cortex decreased from pre to post bed rest. Furthermore, connectivity between cerebellar right superior posterior fissure and other cerebellar regions decreased from

  6. Cognitive Rest: An Integrated Literature Review

    Science.gov (United States)

    Schneider, Kathleen H.

    2016-01-01

    Cognitive rest has been suggested as a treatment for school athletes who have sustained a concussion, but the concept has rarely been defined. The purpose of this article is to provide a comprehensive definition of cognitive rest, based on an integrative literature review. The method of synthesis was guided by Avant and Walker's concept analysis…

  7. Resting state EEG correlates of memory consolidation.

    Science.gov (United States)

    Brokaw, Kate; Tishler, Ward; Manceor, Stephanie; Hamilton, Kelly; Gaulden, Andrew; Parr, Elaine; Wamsley, Erin J

    2016-04-01

    Numerous studies demonstrate that post-training sleep benefits human memory. At the same time, emerging data suggest that other resting states may similarly facilitate consolidation. In order to identify the conditions under which non-sleep resting states benefit memory, we conducted an EEG (electroencephalographic) study of verbal memory retention across 15min of eyes-closed rest. Participants (n=26) listened to a short story and then either rested with their eyes closed, or else completed a distractor task for 15min. A delayed recall test was administered immediately following the rest period. We found, first, that quiet rest enhanced memory for the short story. Improved memory was associated with a particular EEG signature of increased slow oscillatory activity (rest can facilitate memory, and that this may occur via an active process of consolidation supported by slow oscillatory EEG activity and characterized by decreased attention to the external environment. Slow oscillatory EEG rhythms are proposed to facilitate memory consolidation during sleep by promoting hippocampal-cortical communication. Our findings suggest that EEG slow oscillations could play a significant role in memory consolidation during other resting states as well. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Clinical applications of resting state functional connectivity

    Directory of Open Access Journals (Sweden)

    Michael D Fox

    2010-06-01

    Full Text Available During resting conditions the brain remains functionally and metabolically active. One manifestation of this activity that has become an important research tool is spontaneous fluctuations in the blood oxygen level dependent (BOLD signal of fMRI. The identification of correlation patterns in these spontaneous fluctuations has been termed resting state functional connectivity (fcMRI and has the potential to greatly increase the translation of fMRI into clinical care. In this article we review the advantages of the resting state signal for clinical applications including detailed discussion of signal to noise considerations. We include guidelines for performing resting state research on clinical populations, outline the different areas for clinical application, and identify important barriers to be addressed to facilitate the translation of resting state fcMRI into the clinical realm.

  9. Cognitive and default-mode resting state networks: do male and female brains "rest" differently?

    Science.gov (United States)

    Weissman-Fogel, Irit; Moayedi, Massieh; Taylor, Keri S; Pope, Geoff; Davis, Karen D

    2010-11-01

    Variability in human behavior related to sex is supported by neuroimaging studies showing differences in brain activation patterns during cognitive task performance. An emerging field is examining the human connectome, including networks of brain regions that are not only temporally-correlated during different task conditions, but also networks that show highly correlated spontaneous activity during a task-free state. Both task-related and task-free network activity has been associated with individual task performance and behavior under certain conditions. Therefore, our aim was to determine whether sex differences exist during a task-free resting state for two networks associated with cognitive task performance (executive control network (ECN), salience network (SN)) and the default mode network (DMN). Forty-nine healthy subjects (26 females, 23 males) underwent a 5-min task-free fMRI scan in a 3T MRI. An independent components analysis (ICA) was performed to identify the best-fit IC for each network based on specific spatial nodes defined in previous studies. To determine the consistency of these networks across subjects we performed self-organizing group-level ICA analyses. There were no significant differences between sexes in the functional connectivity of the brain areas within the ECN, SN, or the DMN. These important findings highlight the robustness of intrinsic connectivity of these resting state networks and their similarity between sexes. Furthermore, our findings suggest that resting state fMRI studies do not need to be controlled for sex. © 2010 Wiley-Liss, Inc.

  10. Spectroscopic and DFT Studies of Second Sphere Variants of the Type 1 Copper Site in Azurin: Covalent and Non-Local Electrostatic Contributions to Reduction Potentials

    Science.gov (United States)

    Hadt, Ryan G.; Sun, Ning; Marshall, Nicholas M.; Hodgson, Keith O.; Hedman, Britt; Lu, Yi; Solomon, Edward I.

    2012-01-01

    The reduction potentials (E0) of type 1 (T1) or blue copper (BC) sites in proteins and enzymes with identical first coordination spheres around the redox active copper ion can vary by ~400 mV. Here, we use a combination of low temperature electronic absorption and magnetic circular dichroism, electron paramagnetic resonance, resonance Raman, and S K-edge X-ray absorption spectroscopies to investigate a series of second sphere variants—F114P, N47S, and F114N in Pseudomonas aeruginosa azurin (Az)—which modulate hydrogen bonding to and protein derived dipoles nearby the Cu-S(Cys) bond. Density functional theory (DFT) calculations correlated to the experimental data allow for the fractionation of the contributions to tuning E0 into covalent and non-local electrostatic components. These are found to be significant, comparable in magnitude, and additive for active H-bonds, while passive H-bonds are mostly non-local electrostatic in nature. For dipoles, these terms can be additive to or oppose one another. This study provides a methodology for uncoupling covalency from non-local electrostatics, which, when coupled to X-ray crystallographic data, distinguishes specific local interactions from more long range protein/active interactions, while affording further insight into the second sphere mechanisms available to the protein to tune the E0 of electron transfer sites in biology. PMID:22985400

  11. Challenges in Upscaling Geomorphic Transport Laws: Scale-dependence of Local vs. Non-local Formalisms and Derivation of Closures (Invited)

    Science.gov (United States)

    Foufoula-Georgiou, E.; Ganti, V. K.; Passalacqua, P.

    2010-12-01

    Nonlinear geomorphic transport laws are often derived from mechanistic considerations at a point, and yet they are implemented on 90m or 30 m DEMs, presenting a mismatch in the scales of derivation and application of the flux laws. Since estimates of local slopes and curvatures are known to depend on the scale of the DEM used in their computation, two questions arise: (1) how to meaningfully compensate for the scale dependence, if any, of local transport laws? and (2) how to formally derive, via upscaling, constitutive laws that are applicable at larger scales? Recently, non-local geomorphic transport laws for sediment transport on hillslopes have been introduced using the concept of an integral flux that depends on topographic attributes in the vicinity of a point of interest. In this paper, we demonstrate the scale dependence of local nonlinear hillslope sediment transport laws and derive a closure term via upscaling (Reynolds averaging). We also show that the non-local hillslope transport laws are inherently scale independent owing to their non-local, scale-free nature. These concepts are demonstrated via an application to a small subbasin of the Oregon Coast Range using 2m LiDAR topographic data.

  12. Factorization and non-local 1/m{sub b} corrections in the decay anti B {yields} X{sub s}{gamma}

    Energy Technology Data Exchange (ETDEWEB)

    Benzke, Michael

    2011-06-10

    In this thesis, a systematic analysis of the anti B {yields} X{sub s}{gamma} photon spectrum in the endpoint region is presented. The endpoint region refers to a kinematic configuration of the final state, in which the photon has a large energy m{sub b}-2E{sub {gamma}}=O({lambda}{sub QCD}), while the jet has a large energy but small invariant mass. Using methods of soft-collinear effective theory and heavy-quark effective theory, it is shown that the spectrum can be factorized into hard, jet, and soft functions, each encoding the dynamics at a certain scale. The relevant scales in the endpoint region are the heavy-quark mass m{sub b}, the hadronic energy scale {lambda}{sub QCD} and an intermediate scale {radical}({lambda}{sub QCD}m{sub b}) associated with the invariant mass of the jet. It is found that the factorization formula contains two different types of contributions, distinguishable by the space-time structure of the underlying diagrams. On the one hand, there are the direct photon contributions which correspond to diagrams with the photon emitted directly from the weak vertex. The resolved photon contributions on the other hand arise at O(1/m{sub b}) whenever the photon couples to light partons. In this work, these contributions are explicitly defined in terms of convolutions of jet functions with subleading shape functions. While the direct photon contributions can be expressed in terms of a local operator product expansion, when the photon spectrum is integrated over a range larger than the endpoint region, the resolved photon contributions always remain non-local. Thus, they are responsible for a non-perturbative uncertainty on the partonic predictions. In this thesis, the effect of these uncertainties is estimated in two different phenomenological contexts. First, the hadronic uncertainties in the anti B {yields} X{sub s}{gamma} branching fraction, defined with a cut E{sub {gamma}} > 1.6GeV are discussed. It is found, that the resolved photon

  13. The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study

    NARCIS (Netherlands)

    Bosma, I.; Stam, C.; Douw, L.; Bartolomei, F.; Heimans, J.; Dijk, van B.; Postma, T.; Klein, M.; Reijneveld, J.

    2008-01-01

    Purpose: In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain

  14. The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study

    NARCIS (Netherlands)

    Bosma, I.; Stam, C. J.; Douw, L.; Bartolomei, F.; Heimans, J. J.; van Dijk, B. W.; Postma, T. J.; Klein, M.; Reijneveld, J. C.

    2008-01-01

    In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain activity

  15. Focal Gray Matter Plasticity as a Function of Long Duration Head-down Tilt Bed Rest

    Science.gov (United States)

    Koppelmans, V.; DeDios, Y. E.; Wood, S. J.; Reuter-Lorenz, P. A.; Kofman, I.; Bloomberg, J. J.; Mulavara, A. P.; Koppelmans, V.

    2014-01-01

    Long duration spaceflight (i.e., > or = 22 days) has been associated with changes in sensorimotor systems, resulting in difficulties that astronauts experience with posture control, locomotion, and manual control. The microgravity environment is an important causal factor for spaceflight induced sensorimotor changes. Whether these sensorimotor changes may be related to structural and functional brain changes is yet unknown. However, experimental studies revealed changes in the gray matter (GM) of the brain after simulated microgravity. Thus, it is possible that spaceflight may affect brain structure and thereby cognitive functioning and motor behavior. Long duration head-down tilt bed rest has been suggested as an exclusionary analog to study microgravity effects on the sensorimotor system. Bed rest mimics microgravity in body unloading and bodily fluid shifts. In consideration of the health and performance of crewmembers both in- and post-flight, we are conducting a prospective longitudinal 70-day bed rest study as an analog to investigate the effects of microgravity on the brain. VBM analysis revealed a progressive decrease from pre- to in- bed rest in GM volume in bilateral areas including the frontal medial cortex, the insular cortex and the caudate. Over the same time period, there was a progressive increase in GM volume in the cerebellum, occipital-, and parietal cortex, including the precuneus. The majority of these changes did not fully recover during the post-bed rest period. Analysis of lobular GM volumes obtained with BRAINS showed significantly increased volume from pre-bed rest to in-bed rest in GM of the parietal lobe and the third ventricle. Temporal GM volume at 70 days in bed rest was smaller than that at the first pre-bed rest measurement. Trend analysis showed significant positive linear and negative quadratic relationships between parietal GM and time, a positive linear relationship between third ventricle volume and time, and a negative linear

  16. RESTful Java patterns and best practices

    CERN Document Server

    Mehta, Bhakti

    2014-01-01

    This book is aimed at novice developers who want to gain insights into building RESTful services and improve productivity, as well as for advanced developers who want to delve into more complicated topics.

  17. Brief wakeful resting can eliminate directed forgetting.

    Science.gov (United States)

    Schlichting, Andreas; Bäuml, Karl-Heinz T

    2017-02-01

    When cued to intentionally forget previously encoded memories, participants typically show reduced recall of the memories on a later recall test. We examined how such directed forgetting is affected by a brief period of wakeful resting between encoding and test. Encoding was followed by a "passive" wakeful resting period in which subjects heard emotionally neutral music or perceived neutral pictures, or it was followed by an "active" distraction period in which subjects were engaged in counting or calculation tasks. Whereas typical directed forgetting was present after active distraction, the forgetting was absent after wakeful resting. The findings indicate that the degree to which people can intentionally forget memories is influenced by the cognitive activity that people engage in shortly after learning takes place. The results provide first evidence on the interplay between wakeful resting and intentional forgetting.

  18. Partnership strategies for safety roadside rest areas.

    Science.gov (United States)

    2009-01-01

    This project studied the many factors influencing the potential for public private partnerships for Safety : Roadside Rest Areas. It found that Federal and California State laws and regulations represent important : barriers to certain types and loca...

  19. Elegants ja eklektika - Rest Art / Lylian Meister

    Index Scriptorium Estoniae

    Meister, Lylian, 1966-

    2007-01-01

    Tallinnas Mustika keskuses asuvas sisustussalongis Rest Art pakutavast. Asjade müümise kõrval pakutakse kodudele ja hotellidele-restoranidele terviklahendusi. Salongi kujundas Kard Männil. 4 värv. vaadet

  20. USAJOBS Job Opportunity Announcements (JOA) REST API

    Data.gov (United States)

    Office of Personnel Management — This REST-based API is designed to support lightweight Federal Job Opportunity Announcement (JOA) content consumption by consumers. It is anticipated that this API...

  1. Resting cardiointegram: correlation with stress thallium perfusion studies

    International Nuclear Information System (INIS)

    Gould, L.A.; Betzu, R.; Judge, D.; Lee, J.; Taddeo, M.; Yang, D.

    1988-01-01

    The cardiointegram is a noninvasive technique for the analysis of the electrical signals of the heart obtained by a transformation of the voltage versus time format by a series of integrations. The stress thallium perfusion study is a widely used test for the detection of coronary artery disease. In order to evaluate the correlation between the resting cardiointegram and the stress thallium 201 perfusion study, 20 patients with normal resting electrocardiograms underwent stress thallium tests and resting cardiointegrams. The cardiointegram was determined on two resting complexes of leads I, II, V4, V5, and V6 and called abnormal if five of ten complexes deviated outside a normalized template. There was concordance of the cardiointegram and the thallium study in 16 of 20 patients (80%). The sensitivity for the detection of coronary artery disease was 71%, and the specificity was 80%. The overall accuracy was 74%. Thus in patients with normal electrocardiograms, the cardiointegram is a useful noninvasive test for the detection of coronary artery disease

  2. Infraslow Electroencephalographic and Dynamic Resting State Network Activity.

    Science.gov (United States)

    Grooms, Joshua K; Thompson, Garth J; Pan, Wen-Ju; Billings, Jacob; Schumacher, Eric H; Epstein, Charles M; Keilholz, Shella D

    2017-06-01

    A number of studies have linked the blood oxygenation level dependent (BOLD) signal to electroencephalographic (EEG) signals in traditional frequency bands (δ, θ, α, β, and γ), but the relationship between BOLD and its direct frequency correlates in the infraslow band (resting state magnetic resonance imaging data were acquired simultaneously. The DC EEG signals were correlated with the BOLD signal in patterns that resembled resting state networks. Subsequent dynamic analysis showed that the correlation between DC EEG and the BOLD signal varied substantially over time, even within individual subjects. The variation in DC EEG appears to reflect the time-varying contribution of different resting state networks. Furthermore, some of the patterns of DC EEG and BOLD correlation are consistent with previous work demonstrating quasiperiodic spatiotemporal patterns of large-scale network activity in resting state. These findings demonstrate that infraslow electrical activity is linked to BOLD fluctuations in humans and that it may provide a basis for large-scale organization comparable to that observed in animal studies.

  3. The Physiology of Bed Rest. Chapter 39

    Science.gov (United States)

    Fortney, Suzanne M.; Schneider, Victor S.; Greenleaf, John E.

    1996-01-01

    Prolonged rest in bed has been utilized by physicians and other health-care workers to immobilize and confine patients for rehabilitation and restoration of health since time immemorial. The sitting or horizontal position is sought by the body to relieve the strain of the upright or vertical postures, for example during syncopal situations, bone fractures, muscle injuries, fatigue, and probably also to reduce energy expenditure. Most health-care personnel are aware that adaptive responses occurring during bed rest proceed concomitantly with the healing process; signs and symptoms associated with the former should be differentiated from those of the latter. Not all illnesses and infirmities benefit from prolonged bed rest. Considerations in prescribing bed rest for patients-including duration, body position, mode and duration of exercise, light-dark cycles, temperature, and humidity-have not been investigated adequately. More recently, adaptive physiological responses have been measured in normal, healthy subjects in the horizontal or slightly head-down postures during prolonged bed rest as analogs for the adaptive responses of astronauts exposed to the microgravity environment of outer and bed-rest research.

  4. Pion correlations and resonance effects in pbarp annihilation at rest

    International Nuclear Information System (INIS)

    Weber, Peter

    1999-01-01

    We study ππ correlations in the exclusive reactions pbarp → 2π + 2π - and pbarp → 2π + 2π - π 0 at rest with complete reconstruction of the kinematics for each event. A new analysis technique has been developed which is model independent. With this new technique, which relies on double-differential distributions, no reference sample is needed to extract the correlation signal. The correlations are studied as a function of the four-pion invariant mass

  5. Effects of non-local electron transport in one-dimensional and two-dimensional simulations of shock-ignited inertial confinement fusion targets

    Energy Technology Data Exchange (ETDEWEB)

    Marocchino, A.; Atzeni, S.; Schiavi, A. [Dipartimento SBAI, Università di Roma “La Sapienza” and CNISM, Roma 00161 (Italy)

    2014-01-15

    In some regions of a laser driven inertial fusion target, the electron mean-free path can become comparable to or even longer than the electron temperature gradient scale-length. This can be particularly important in shock-ignited (SI) targets, where the laser-spike heated corona reaches temperatures of several keV. In this case, thermal conduction cannot be described by a simple local conductivity model and a Fick's law. Fluid codes usually employ flux-limited conduction models, which preserve causality, but lose important features of the thermal flow. A more accurate thermal flow modeling requires convolution-like non-local operators. In order to improve the simulation of SI targets, the non-local electron transport operator proposed by Schurtz-Nicolaï-Busquet [G. P. Schurtz et al., Phys. Plasmas 7, 4238 (2000)] has been implemented in the DUED fluid code. Both one-dimensional (1D) and two-dimensional (2D) simulations of SI targets have been performed. 1D simulations of the ablation phase highlight that while the shock profile and timing might be mocked up with a flux-limiter; the electron temperature profiles exhibit a relatively different behavior with no major effects on the final gain. The spike, instead, can only roughly be reproduced with a fixed flux-limiter value. 1D target gain is however unaffected, provided some minor tuning of laser pulses. 2D simulations show that the use of a non-local thermal conduction model does not affect the robustness to mispositioning of targets driven by quasi-uniform laser irradiation. 2D simulations performed with only two final polar intense spikes yield encouraging results and support further studies.

  6. Effects of non-local electron transport in one-dimensional and two-dimensional simulations of shock-ignited inertial confinement fusion targets

    International Nuclear Information System (INIS)

    Marocchino, A.; Atzeni, S.; Schiavi, A.

    2014-01-01

    In some regions of a laser driven inertial fusion target, the electron mean-free path can become comparable to or even longer than the electron temperature gradient scale-length. This can be particularly important in shock-ignited (SI) targets, where the laser-spike heated corona reaches temperatures of several keV. In this case, thermal conduction cannot be described by a simple local conductivity model and a Fick's law. Fluid codes usually employ flux-limited conduction models, which preserve causality, but lose important features of the thermal flow. A more accurate thermal flow modeling requires convolution-like non-local operators. In order to improve the simulation of SI targets, the non-local electron transport operator proposed by Schurtz-Nicolaï-Busquet [G. P. Schurtz et al., Phys. Plasmas 7, 4238 (2000)] has been implemented in the DUED fluid code. Both one-dimensional (1D) and two-dimensional (2D) simulations of SI targets have been performed. 1D simulations of the ablation phase highlight that while the shock profile and timing might be mocked up with a flux-limiter; the electron temperature profiles exhibit a relatively different behavior with no major effects on the final gain. The spike, instead, can only roughly be reproduced with a fixed flux-limiter value. 1D target gain is however unaffected, provided some minor tuning of laser pulses. 2D simulations show that the use of a non-local thermal conduction model does not affect the robustness to mispositioning of targets driven by quasi-uniform laser irradiation. 2D simulations performed with only two final polar intense spikes yield encouraging results and support further studies

  7. Effects of non-local electron transport in one-dimensional and two-dimensional simulations of shock-ignited inertial confinement fusion targets

    Science.gov (United States)

    Marocchino, A.; Atzeni, S.; Schiavi, A.

    2014-01-01

    In some regions of a laser driven inertial fusion target, the electron mean-free path can become comparable to or even longer than the electron temperature gradient scale-length. This can be particularly important in shock-ignited (SI) targets, where the laser-spike heated corona reaches temperatures of several keV. In this case, thermal conduction cannot be described by a simple local conductivity model and a Fick's law. Fluid codes usually employ flux-limited conduction models, which preserve causality, but lose important features of the thermal flow. A more accurate thermal flow modeling requires convolution-like non-local operators. In order to improve the simulation of SI targets, the non-local electron transport operator proposed by Schurtz-Nicolaï-Busquet [G. P. Schurtz et al., Phys. Plasmas 7, 4238 (2000)] has been implemented in the DUED fluid code. Both one-dimensional (1D) and two-dimensional (2D) simulations of SI targets have been performed. 1D simulations of the ablation phase highlight that while the shock profile and timing might be mocked up with a flux-limiter; the electron temperature profiles exhibit a relatively different behavior with no major effects on the final gain. The spike, instead, can only roughly be reproduced with a fixed flux-limiter value. 1D target gain is however unaffected, provided some minor tuning of laser pulses. 2D simulations show that the use of a non-local thermal conduction model does not affect the robustness to mispositioning of targets driven by quasi-uniform laser irradiation. 2D simulations performed with only two final polar intense spikes yield encouraging results and support further studies.

  8. Changes in dynamic resting state network connectivity following aphasia therapy.

    Science.gov (United States)

    Duncan, E Susan; Small, Steven L

    2017-10-24

    Resting state magnetic resonance imaging (rsfMRI) permits observation of intrinsic neural networks produced by task-independent correlations in low frequency brain activity. Various resting state networks have been described, with each thought to reflect common engagement in some shared function. There has been limited investigation of the plasticity in these network relationships after stroke or induced by therapy. Twelve individuals with language disorders after stroke (aphasia) were imaged at multiple time points before (baseline) and after an imitation-based aphasia therapy. Language assessment using a narrative production task was performed at the same time points. Group independent component analysis (ICA) was performed on the rsfMRI data to identify resting state networks. A sliding window approach was then applied to assess the dynamic nature of the correlations among these networks. Network correlations during each 30-second window were used to cluster the data into ten states for each window at each time point for each subject. Correlation was performed between changes in time spent in each state and therapeutic gains on the narrative task. The amount of time spent in a single one of the (ten overall) dynamic states was positively associated with behavioral improvement on the narrative task at the 6-week post-therapy maintenance interval, when compared with either baseline or assessment immediately following therapy. This particular state was characterized by minimal correlation among the task-independent resting state networks. Increased functional independence and segregation of resting state networks underlies improvement on a narrative production task following imitation-based aphasia treatment. This has important clinical implications for the targeting of noninvasive brain stimulation in post-stroke remediation.

  9. A DGTD method for the numerical modeling of the interaction of light with nanometer scale metallic structures taking into account non-local dispersion effects

    Energy Technology Data Exchange (ETDEWEB)

    Schmitt, Nikolai [Inria, 2004 Route des Lucioles, BP 93, 06902 Sophia Antipolis Cedex (France); Technische Universitaet Darmstadt, Institut fuer Theorie Elektromagnetischer Felder (TEMF), Schlossgartenstr. 8, 64289 Darmstadt (Germany); Scheid, Claire [Inria, 2004 Route des Lucioles, BP 93, 06902 Sophia Antipolis Cedex (France); University of Nice – Sophia Antipolis, Mathematics laboratory, Parc Valrose, 06108 Nice, Cedex 02 (France); Lanteri, Stéphane, E-mail: Stephane.Lanteri@inria.fr [Inria, 2004 Route des Lucioles, BP 93, 06902 Sophia Antipolis Cedex (France); Moreau, Antoine [Institut Pascal, Université Blaise Pascal, 24, avenue des Landais, 63171 Aubière Cedex (France); Viquerat, Jonathan [Inria, 2004 Route des Lucioles, BP 93, 06902 Sophia Antipolis Cedex (France)

    2016-07-01

    The interaction of light with metallic nanostructures is increasingly attracting interest because of numerous potential applications. Sub-wavelength metallic structures, when illuminated with a frequency close to the plasma frequency of the metal, present resonances that cause extreme local field enhancements. Exploiting the latter in applications of interest requires a detailed knowledge about the occurring fields which can actually not be obtained analytically. For the latter mentioned reason, numerical tools are thus an absolute necessity. The insight they provide is very often the only way to get a deep enough understanding of the very rich physics at play. For the numerical modeling of light-structure interaction on the nanoscale, the choice of an appropriate material model is a crucial point. Approaches that are adopted in a first instance are based on local (i.e. with no interaction between electrons) dispersive models, e.g. Drude or Drude–Lorentz models. From the mathematical point of view, when a time-domain modeling is considered, these models lead to an additional system of ordinary differential equations coupled to Maxwell's equations. However, recent experiments have shown that the repulsive interaction between electrons inside the metal makes the response of metals intrinsically non-local and that this effect cannot generally be overlooked. Technological achievements have enabled the consideration of metallic structures in a regime where such non-localities have a significant influence on the structures' optical response. This leads to an additional, in general non-linear, system of partial differential equations which is, when coupled to Maxwell's equations, significantly more difficult to treat. Nevertheless, dealing with a linearized non-local dispersion model already opens the route to numerous practical applications of plasmonics. In this work, we present a Discontinuous Galerkin Time-Domain (DGTD) method able to solve the system

  10. Unique solvability of a non-linear non-local boundary-value problem for systems of non-linear functional differential equations

    Czech Academy of Sciences Publication Activity Database

    Dilna, N.; Rontó, András

    2010-01-01

    Roč. 60, č. 3 (2010), s. 327-338 ISSN 0139-9918 R&D Projects: GA ČR(CZ) GA201/06/0254 Institutional research plan: CEZ:AV0Z10190503 Keywords : non-linear boundary value-problem * functional differential equation * non-local condition * unique solvability * differential inequality Subject RIV: BA - General Mathematics Impact factor: 0.316, year: 2010 http://link.springer.com/article/10.2478%2Fs12175-010-0015-9

  11. Benefits of public roadside safety rest areas in Texas : technical report.

    Science.gov (United States)

    2011-05-01

    The objective of this investigation was to develop a benefit-cost analysis methodology for safety rest areas in : Texas and to demonstrate its application in select corridors throughout the state. In addition, this project : considered novel safety r...

  12. Analysis by rotavirus gene 6 reverse transcriptase-polymerase chain reaction assay of rotavirus-positive gastroenteritis cases observed during the vaccination phase of the Rotavirus Efficacy and Safety Trial (REST)

    Science.gov (United States)

    Matson, David O; Vesikari, Timo; Dennehy, Penelope; Dallas, Michael D; Goveia, Michelle G; Itzler, Robbin F; Ciarlet, Max

    2014-01-01

    During the vaccination phase of the Rotavirus Efficacy and Safety Trial (REST), the period between the administration of dose 1 through 13 days after the administration of dose 3, there were more wild-type rotavirus gastroenteritis (RVGE) cases among vaccine recipients compared with placebo recipients using the protocol-specified microbiological plaque assay in the clinical-efficacy cohort, a subset of subjects where vaccine efficacy against RVGE of any severity was assessed. In this study, a rotavirus genome segment 6-based reverse transcriptase–polymerase chain reaction assay was applied post hoc to clarify the accuracy of type categorization of all these RVGE cases in vaccine recipients during the vaccination phase of REST. The assay characterized 147 (90%) of 163 re-assayed RVGE cases or rotavirus-associated health care contacts as type-determinable: either wild-type or vaccine-type rotavirus strains. In the clinical-efficacy cohort (N = 5673), 19 (18.8%) of 101 samples from RVGE cases contained wild-type rotavirus, 70 (69.3%) vaccine virus, and 12 (11.9%) were indeterminable. In the large-scale cohort (N = 68,038), 10 (34.5%) of 29 samples from RVGE-related health care contacts contained wild-type rotavirus strains, 15 (51.7%) vaccine-type rotavirus strains, and 4 (13.8%) were indeterminable. Of the 33 samples from RVGE cases in placebo recipients, all were confirmed to contain wild-type rotaviruses. Altogether, this post-hoc re-evaluation showed that the majority (75%) of type-determinable RVGE cases or health care contacts that occurred during the vaccination phase of REST in vaccine recipients were associated with vaccine-type rotavirus strains rather than wild-type rotavirus strains. PMID:25424931

  13. Analysis by rotavirus gene 6 reverse transcriptase-polymerase chain reaction assay of rotavirus-positive gastroenteritis cases observed during the vaccination phase of the Rotavirus Efficacy and Safety Trial (REST).

    Science.gov (United States)

    Matson, David O; Vesikari, Timo; Dennehy, Penelope; Dallas, Michael D; Goveia, Michelle G; Itzler, Robbin F; Ciarlet, Max

    2014-01-01

    During the vaccination phase of the Rotavirus Efficacy and Safety Trial (REST), the period between the administration of dose 1 through 13 days after the administration of dose 3, there were more wild-type rotavirus gastroenteritis (RVGE) cases among vaccine recipients compared with placebo recipients using the protocol-specified microbiological plaque assay in the clinical-efficacy cohort, a subset of subjects where vaccine efficacy against RVGE of any severity was assessed. In this study, a rotavirus genome segment 6-based reverse transcriptase-polymerase chain reaction assay was applied post hoc to clarify the accuracy of type categorization of all these RVGE cases in vaccine recipients during the vaccination phase of REST. The assay characterized 147 (90%) of 163 re-assayed RVGE cases or rotavirus-associated health care contacts as type-determinable: either wild-type or vaccine-type rotavirus strains. In the clinical-efficacy cohort (N = 5673), 19 (18.8%) of 101 samples from RVGE cases contained wild-type rotavirus, 70 (69.3%) vaccine virus, and 12 (11.9%) were indeterminable. In the large-scale cohort (N = 68,038), 10 (34.5%) of 29 samples from RVGE-related health care contacts contained wild-type rotavirus strains, 15 (51.7%) vaccine-type rotavirus strains, and 4 (13.8%) were indeterminable. Of the 33 samples from RVGE cases in placebo recipients, all were confirmed to contain wild-type rotaviruses. Altogether, this post-hoc re-evaluation showed that the majority (75%) of type-determinable RVGE cases or health care contacts that occurred during the vaccination phase of REST in vaccine recipients were associated with vaccine-type rotavirus strains rather than wild-type rotavirus strains.

  14. A novel segmentation method for uneven lighting image with noise injection based on non-local spatial information and intuitionistic fuzzy entropy

    Science.gov (United States)

    Yu, Haiyan; Fan, Jiulun

    2017-12-01

    Local thresholding methods for uneven lighting image segmentation always have the limitations that they are very sensitive to noise injection and that the performance relies largely upon the choice of the initial window size. This paper proposes a novel algorithm for segmenting uneven lighting images with strong noise injection based on non-local spatial information and intuitionistic fuzzy theory. We regard an image as a gray wave in three-dimensional space, which is composed of many peaks and troughs, and these peaks and troughs can divide the image into many local sub-regions in different directions. Our algorithm computes the relative characteristic of each pixel located in the corresponding sub-region based on fuzzy membership function and uses it to replace its absolute characteristic (its gray level) to reduce the influence of uneven light on image segmentation. At the same time, the non-local adaptive spatial constraints of pixels are introduced to avoid noise interference with the search of local sub-regions and the computation of local characteristics. Moreover, edge information is also taken into account to avoid false peak and trough labeling. Finally, a global method based on intuitionistic fuzzy entropy is employed on the wave transformation image to obtain the segmented result. Experiments on several test images show that the proposed method has excellent capability of decreasing the influence of uneven illumination on images and noise injection and behaves more robustly than several classical global and local thresholding methods.

  15. Bipartite non-classical correlations for a lossy two connected qubit-cavity systems: trace distance discord and Bell's non-locality

    Science.gov (United States)

    Mohamed, Abdel-Baset A.

    2018-04-01

    In this paper, some non-classical correlations are investigated for bipartite partitions of two qubits trapped in two spatially separated cavities connected by an optical fiber. The results show that the trace distance discord and Bell's non-locality introduce other quantum correlations beyond the entanglement. Moreover, the correlation functions of the trace distance discord and the Bell's non-locality are very sensitive to the initial correlations, the coupling strengths, and the dissipation rates of the cavities. The fluctuations of the correlation functions between their initial values and gained (loss) values appear due to the unitary evolution of the system. These fluctuations depend on the chosen initial correlations between the two subsystems. The maximal violations of Bell's inequality occur when the logarithmic negativity and the trace distance discord reach certain values. It is shown that the robustness of the non-classical correlations, against the dissipation rates of the cavities, depends on the bipartite partitions reduced density matrices of the system, and is also greatly enhanced by choosing appropriate coupling strengths.

  16. Experimental evaluation of the influence of various rests on task performance

    International Nuclear Information System (INIS)

    Nagasaka, Akihiko; Hirose, Ayako

    2000-01-01

    This report deals with the result of the experiment that 8 subjects had executed adding task and search task. They executed each task in 80 minutes under 5 conditions: (1) with no rest, and with 4 kinds of 20 minutes rests, in which they (2) opened eyes, (3) closed eyes, (4) closed eyes with listening classic music and (5) closed eyes with feet massage, in the middle of the task. The results of analysis of variance with the task performance in the latter half, there were significant differences between each condition with every subject in adding task, and with 6 subjects in search task. However, the orders of the task performance with each condition were not the same by each subject. It was suggested that transition of the arousal levels under the rest was related to the effects of the rest rather than the subjects' taste in rests. In the rest, the percentage of α wave of electroencephalogram and the coefficient of variation of R-R interval (time interval of heart beats) were increased than in executing task. The mean Kendall's rank correlation of coefficient with the order of increase rate of α/β wave and the task performance in the latter half was slightly negative in adding task, but was about 0.4 in search task. From these results, about six requirements for 'an effective rest' were able to be mentioned, for example, 'the devices that raises the arousal levels is carried out just before a rest end'. (author)

  17. REST-mediated recruitment of polycomb repressor complexes in mammalian cells

    DEFF Research Database (Denmark)

    Dietrich, Nikolaj; Lerdrup, Mads; Landt, Eskild

    2012-01-01

    Polycomb Repressive Complex (PRC) 1 and PRC2 regulate genes involved in differentiation and development. However, the mechanism for how PRC1 and PRC2 are recruited to genes in mammalian cells is unclear. Here we present evidence for an interaction between the transcription factor REST, PRC1......, and increased gene expression. Genome-wide analysis of Polycomb binding in Rest¿/¿ and Eed¿/¿ mouse embryonic stem (mES) cells showed that Rest was required for PRC1 recruitment to a subset of Polycomb regulated neuronal genes. Furthermore, we found that PRC1 can be recruited to Rest binding sites independently...... of CpG islands and the H3K27Me3 mark. Surprisingly, PRC2 was frequently increased around Rest binding sites located in CpG-rich regions in the Rest¿/¿ mES cells, indicating a more complex interplay where Rest also can limit PRC2 recruitment. Therefore, we propose that Rest has context...

  18. High Vegetable Fats Intake Is Associated with High Resting Energy Expenditure in Vegetarians

    Directory of Open Access Journals (Sweden)

    Tiziana Montalcini

    2015-07-01

    Full Text Available It has been demonstrated that a vegetarian diet may be effective in reducing body weight, however, the underlying mechanisms are not entirely clear. We investigated whether there is a difference in resting energy expenditure between 26 vegetarians and 26 non-vegetarians and the correlation between some nutritional factors and inflammatory markers with resting energy expenditure. In this cross-sectional study, vegetarians and non-vegetarians were matched by age, body mass index and gender. All underwent instrumental examinations to assess the difference in body composition, nutrient intake and resting energy expenditure. Biochemical analyses and 12 different cytokines and growth factors were measured as an index of inflammatory state. A higher resting energy expenditure was found in vegetarians than in non-vegetarians (p = 0.008. Furthermore, a higher energy from diet, fibre, vegetable fats intake and interleukin-β (IL-1β was found between the groups. In the univariate and multivariable analysis, resting energy expenditure was associated with vegetarian diet, free-fat mass and vegetable fats (p < 0.001; Slope in statistic (B = 4.8; β = 0.42. After adjustment for cytokines, log10 interleukin-10 (IL-10 still correlated with resting energy expenditure (p = 0.02. Resting energy expenditure was positively correlated with a specific component of the vegetarian’s diet, i.e., vegetable fats. Furthermore, we showed that IL-10 was positively associated with resting energy expenditure in this population.

  19. Antiproton-neutron annihilations at rest: Search for broad states

    International Nuclear Information System (INIS)

    Kalogeropoulos, T.E.

    1985-01-01

    The searches so far for meson states produced in p-bar annihilations at rest into π+X have been sensitive to narrow X states. The combinatorial background and the narrow phase space width in missing mass spectra are the main problems. Most of the theoretical models predict broad states. We have measured in a high statistis experiment p-bar(at rest)d→π/sup +- /+Anything inclusive spectra. Using a novel analysis technique the π + π - difference spectra, it is shown that the p-barn annihilation is dominated by two-body cascades. Two new states of opposite G-parity of (mass, width) = (1480, 100) MeV/c 2 are dominant. The G = +1 state has a large decay branching ratio into rho 0 rho 0 . Other features are presented

  20. Dose and effect of inhaled ozone in resting versus exercising human subjects: comparison with resting rats

    Science.gov (United States)

    Dose and effect of inhaled ozone in resting versus exercising human subjects: comparison with resting rats Authors: Gary E. Hatch, John McKee, James Brown, Bill McDonnell, Elston Seal, Joleen Soukup, Ralph Slade, Kay Crissman and Robert Devlin, National Health and Environmental...

  1. Exercise countermeasures for bed-rest deconditioning

    Science.gov (United States)

    Greenleaf, John (Editor)

    1993-01-01

    The purpose for this 30-day bed rest study was to investigate the effects of short-term, high intensity isotonic and isokinetic exercise training on maintenance of working capacity (peak oxygen uptake), muscular strength and endurance, and on orthostatic tolerance, posture and gait. Other data were collected on muscle atrophy, bone mineralization and density, endocrine analyses concerning vasoactivity and fluid-electrolyte balance, muscle intermediary metabolism, and on performance and mood of the subjects. It was concluded that: The subjects maintained a relatively stable mood, high morale, and high esprit de corps throughout the study. Performance improved in nearly all tests in almost all the subjects. Isotonic training, as opposed to isokinetic exercise training, was associated more with decreasing levels of psychological tension, concentration, and motivation; and improvement in the quality of sleep. Working capacity (peak oxygen uptake) was maintained during bed rest with isotonic exercise training; it was not maintained with isokinetic or no exercise training. In general, there was no significant decrease in strength or endurance of arm or leg muscles during bed rest, in spite of some reduction in muscle size (atrophy) of some leg muscles. There was no effect of isotonic exercise training on orthostasis, since tilt-table tolerance was reduced similarly in all three groups following bed rest. Bed rest resulted in significant decreases of postural stability and self-selected step length, stride length, and walking velocity, which were not influenced by either exercise training regimen. Most pre-bed rest responses were restored by the fourth day of recovery.

  2. REST in practice Hypermedia and systems architecture

    CERN Document Server

    Webber, Jim; Robinson, Ian

    2010-01-01

    Why don't typical enterprise projects go as smoothly as projects you develop for the Web? Does the REST architectural style really present a viable alternative for building distributed systems and enterprise-class applications? In this insightful book, three SOA experts provide a down-to-earth explanation of REST and demonstrate how you can develop simple and elegant distributed hypermedia systems by applying the Web's guiding principles to common enterprise computing problems. You'll learn techniques for implementing specific Web technologies and patterns to solve the needs of a typical com

  3. Non-local Thermodynamic Equilibrium Abundance Analyses of the Extreme Helium Stars V652 Her and HD 144941

    International Nuclear Information System (INIS)

    Pandey, Gajendra; Lambert, David L.

    2017-01-01

    Optical high-resolution spectra of V652 Her and HD 144941, the two extreme helium stars with exceptionally low C/He ratios, have been subjected to a non-LTE abundance analysis using the tools TLUSTY and SYNSPEC. Defining atmospheric parameters were obtained from a grid of non-LTE atmospheres and a variety of spectroscopic indicators including He i and He ii line profiles, and the ionization equilibrium of ion pairs such as C ii/C iii and N ii/N iii. The various indicators provide a consistent set of atmospheric parameters: T eff = 25,000 ± 300 K, log g = 3.10 ± 0.12(cgs), and ξ = 13 ± 2 km s −1 are provided for V652 Her, and T eff = 22,000 ± 600 K, log g = 3.45 ± 0.15 (cgs), and ξ = 10 km s −1 are provided for HD 144941. In contrast to the non-LTE analyses, the LTE analyses—LTE atmospheres and an LTE line analysis—with the available indicators do not provide a consistent set of atmospheric parameters. The principal non-LTE effect on the elemental abundances is on the neon abundance. It is generally considered that these extreme helium stars with their very low C/He ratio result from the merger of two helium white dwarfs. Indeed, the derived composition of V652 Her is in excellent agreement with predictions by Zhang and Jeffery, who model the slow merger of helium white dwarfs; a slow merger results in the merged star having the composition of the accreted white dwarf. In the case of HD 144941, which appears to have evolved from metal-poor stars, a slow merger is incompatible with the observed composition but variations of the merger rate may account for the observed composition. More detailed theoretical studies of the merger of a pair of helium white dwarfs are to be encouraged.

  4. 1 SHORT COMMUNICATION Resting behaviour of Anopheles ...

    African Journals Online (AJOL)

    2011-10-04

    Oct 4, 2011 ... Resting behaviour of Anopheles gambiae s.l. and its implication on malaria .... nature) were requested to sleep under the double mosquito net trap (one ... designed from the DNA sequences of the intergenic spacer region of ...

  5. A resting bottom sodium cooled fast reactor

    International Nuclear Information System (INIS)

    Costes, D.

    2012-01-01

    This follows ICAPP 2011 paper 11059 'Fast Reactor with a Cold Bottom Vessel', on sodium cooled reactor vessels in thermal gradient, resting on soil. Sodium is frozen on vessel bottom plate, temperature increasing to the top. The vault cover rests on the safety vessel, the core diagrid welded to a toric collector forms a slab, supported by skirts resting on the bottom plate. Intermediate exchangers and pumps, fixed on the cover, plunge on the collector. At the vessel top, a skirt hanging from the cover plunges into sodium, leaving a thin circular slit partially filled by sodium covered by argon, providing leak-tightness and allowing vessel dilatation, as well as a radial relative holding due to sodium inertia. No 'air conditioning' at 400 deg. C is needed as for hanging vessels, and this allows a large economy. The sodium volume below the slab contains isolating refractory elements, stopping a hypothetical corium flow. The small gas volume around the vessel limits any LOCA. The liner cooling system of the concrete safety vessel may contribute to reactor cooling. The cold resting bottom vessel, proposed by the author for many years, could avoid the complete visual inspection required for hanging vessels. However, a double vessel, containing support skirts, would allow introduction of inspecting devices. Stress limiting thermal gradient is obtained by filling secondary sodium in the intermediate space. (authors)

  6. [Creep of amalgam fillings under clasp rests].

    Science.gov (United States)

    Borchers, L; Jung, T; West, M

    1989-10-01

    A clinically realistic experiment was set up to obtain information on the amount of vertical settling of clasp rests in amalgam restorations under functional loading. Mesioocclusal cavities were prepared in 16 lower molar specimens cast in brass. The cavities were filled with amalgam and provided with a mesial rest seat. A constant load of 100 N was applied via a simplified (experimental) saddle to a cobalt-chromium E-clasp cast to the saddle. The duration of the load corresponded to 160 days of clinical function. The chronological course of vertical displacement was analyzed mathematically. According to this result the process can be divided into three components: settling immediately upon load initiation (mean value 96 microns, transition creep (mean value 25 microns) and creep ata constant rate (mean value 15 microns). The mean overall vertical displacement of the rests was 136 microns, the maximum value 287 microns. These findings suggest that vertical settling of a clasp rest into its seat in an amalgam restoration may eventually result in significant changes in occlusion and may almost completely exhaust gingival resilience.

  7. Solar Lighting Technologies for Highway Green Rest Areas in China: Energy Saving Economic and Environmental Evaluation

    Directory of Open Access Journals (Sweden)

    Xiaochun Qin

    2015-01-01

    Full Text Available In this paper, taking Lushan West Sea highway green rest area in Jiangxi Province of China as the case study, the suitable types, applicability, advantages, and effective methods of solar lighting technologies for highway rest area were determined based on the analysis of characteristics of highway green rest area. It was proved that solar lighting technologies including the natural light guidance system, solar LED lighting, and maximizing natural light penetration were quite suitable for highway rest area in terms of lighting effects and energy and economic efficiency. The illuminance comparison of light guidance system with electrical lighting was made based on the on-site experiment. Also, the feasibility of natural light guidance system was well verified in terms of the lighting demand of the visitor centre in the rest area by the illuminance simulation analysis. The evaluation of the energy saving, economic benefits, and environmental effects of solar lighting technologies for highway rest area was, respectively, made in detail. It was proved that the application of solar technology for green lighting of highway rest facilities not only could have considerable energy saving capacity and achieve high economic benefits, but also make great contributions to the reduction of environment pollution.

  8. Cardiac atrophy after bed rest and spaceflight

    Science.gov (United States)

    Perhonen, M. A.; Franco, F.; Lane, L. D.; Buckey, J. C.; Blomqvist, C. G.; Zerwekh, J. E.; Peshock, R. M.; Weatherall, P. T.; Levine, B. D.

    2001-01-01

    Cardiac muscle adapts well to changes in loading conditions. For example, left ventricular (LV) hypertrophy may be induced physiologically (via exercise training) or pathologically (via hypertension or valvular heart disease). If hypertension is treated, LV hypertrophy regresses, suggesting a sensitivity to LV work. However, whether physical inactivity in nonathletic populations causes adaptive changes in LV mass or even frank atrophy is not clear. We exposed previously sedentary men to 6 (n = 5) and 12 (n = 3) wk of horizontal bed rest. LV and right ventricular (RV) mass and end-diastolic volume were measured using cine magnetic resonance imaging (MRI) at 2, 6, and 12 wk of bed rest; five healthy men were also studied before and after at least 6 wk of routine daily activities as controls. In addition, four astronauts were exposed to the complete elimination of hydrostatic gradients during a spaceflight of 10 days. During bed rest, LV mass decreased by 8.0 +/- 2.2% (P = 0.005) after 6 wk with an additional atrophy of 7.6 +/- 2.3% in the subjects who remained in bed for 12 wk; there was no change in LV mass for the control subjects (153.0 +/- 12.2 vs. 153.4 +/- 12.1 g, P = 0.81). Mean wall thickness decreased (4 +/- 2.5%, P = 0.01) after 6 wk of bed rest associated with the decrease in LV mass, suggesting a physiological remodeling with respect to altered load. LV end-diastolic volume decreased by 14 +/- 1.7% (P = 0.002) after 2 wk of bed rest and changed minimally thereafter. After 6 wk of bed rest, RV free wall mass decreased by 10 +/- 2.7% (P = 0.06) and RV end-diastolic volume by 16 +/- 7.9% (P = 0.06). After spaceflight, LV mass decreased by 12 +/- 6.9% (P = 0.07). In conclusion, cardiac atrophy occurs during prolonged (6 wk) horizontal bed rest and may also occur after short-term spaceflight. We suggest that cardiac atrophy is due to a physiological adaptation to reduced myocardial load and work in real or simulated microgravity and demonstrates the plasticity

  9. Non-local Thermodynamic Equilibrium Abundance Analyses of the Extreme Helium Stars V652 Her and HD 144941

    Energy Technology Data Exchange (ETDEWEB)

    Pandey, Gajendra [Indian Institute of Astrophysics, Bangalore, 560034 (India); Lambert, David L., E-mail: pandey@iiap.res.in, E-mail: dll@astro.as.utexas.edu [The W.J. McDonald Observatory and Department of Astronomy, University of Texas at Austin, Austin, TX 78712-1083 (United States)

    2017-10-01

    Optical high-resolution spectra of V652 Her and HD 144941, the two extreme helium stars with exceptionally low C/He ratios, have been subjected to a non-LTE abundance analysis using the tools TLUSTY and SYNSPEC. Defining atmospheric parameters were obtained from a grid of non-LTE atmospheres and a variety of spectroscopic indicators including He i and He ii line profiles, and the ionization equilibrium of ion pairs such as C ii/C iii and N ii/N iii. The various indicators provide a consistent set of atmospheric parameters: T {sub eff} = 25,000 ± 300 K, log g = 3.10 ± 0.12(cgs), and ξ = 13 ± 2 km s{sup −1} are provided for V652 Her, and T {sub eff} = 22,000 ± 600 K, log g = 3.45 ± 0.15 (cgs), and ξ = 10 km s{sup −1} are provided for HD 144941. In contrast to the non-LTE analyses, the LTE analyses—LTE atmospheres and an LTE line analysis—with the available indicators do not provide a consistent set of atmospheric parameters. The principal non-LTE effect on the elemental abundances is on the neon abundance. It is generally considered that these extreme helium stars with their very low C/He ratio result from the merger of two helium white dwarfs. Indeed, the derived composition of V652 Her is in excellent agreement with predictions by Zhang and Jeffery, who model the slow merger of helium white dwarfs; a slow merger results in the merged star having the composition of the accreted white dwarf. In the case of HD 144941, which appears to have evolved from metal-poor stars, a slow merger is incompatible with the observed composition but variations of the merger rate may account for the observed composition. More detailed theoretical studies of the merger of a pair of helium white dwarfs are to be encouraged.

  10. Infinite Relational Modeling of Functional Connectivity in Resting State fMRI

    DEFF Research Database (Denmark)

    Mørup, Morten; Madsen, Kristoffer H.; Dogonowski, Anne Marie

    2010-01-01

    Functional magnetic resonance imaging (fMRI) can be applied to study the functional connectivity of the neural elements which form complex network at a whole brain level. Most analyses of functional resting state networks (RSN) have been based on the analysis of correlation between the temporal...... dynamics of various regions of the brain. While these models can identify coherently behaving groups in terms of correlation they give little insight into how these groups interact. In this paper we take a different view on the analysis of functional resting state networks. Starting from the definition...... of resting state as functional coherent groups we search for functional units of the brain that communicate with other parts of the brain in a coherent manner as measured by mutual information. We use the infinite relational model (IRM) to quantify functional coherent groups of resting state networks...

  11. A baseline for the multivariate comparison of resting state networks

    Directory of Open Access Journals (Sweden)

    Elena A Allen

    2011-02-01

    Full Text Available As the size of functional and structural MRI datasets expands, it becomes increasingly important to establish a baseline from which diagnostic relevance may be determined, a processing strategy that efficiently prepares data for analysis, and a statistical approach that identifies important effects in a manner that is both robust and reproducible. In this paper, we introduce a multivariate analytic approach that optimizes sensitivity and reduces unnecessary testing. We demonstrate the utility of this mega-analytic approach by identifying the effects of age and gender on the resting state networks of 603 healthy adolescents and adults (mean age: 23.4 years, range: 12 to 71 years. Data were collected on the same scanner, preprocessed using an automated analysis pipeline based in SPM, and studied using group independent component analysis. Resting state networks were identified and evaluated in terms of three primary outcome measures: time course spectral power, spatial map intensity, and functional network connectivity. Results revealed robust effects of age on all three outcome measures, largely indicating decreases in network coherence and connectivity with increasing age. Gender effects were of smaller magnitude but suggested stronger intra-network connectivity in females and more inter-network connectivity in males, particularly with regard to sensorimotor networks. These findings, along with the analysis approach and statistical framework described here, provide a useful baseline for future investigations of brain networks in health and disease.

  12. Resting lateralized activity predicts the cortical response and appraisal of emotions: an fNIRS study.

    Science.gov (United States)

    Balconi, Michela; Grippa, Elisabetta; Vanutelli, Maria Elide

    2015-12-01

    This study explored the effect of lateralized left-right resting brain activity on prefrontal cortical responsiveness to emotional cues and on the explicit appraisal (stimulus evaluation) of emotions based on their valence. Indeed subjective responses to different emotional stimuli should be predicted by brain resting activity and should be lateralized and valence-related (positive vs negative valence). A hemodynamic measure was considered (functional near-infrared spectroscopy). Indeed hemodynamic resting activity and brain response to emotional cues were registered when subjects (N = 19) viewed emotional positive vs negative stimuli (IAPS). Lateralized index response during resting state, LI (lateralized index) during emotional processing and self-assessment manikin rating were considered. Regression analysis showed the significant predictive effect of resting activity (more left or right lateralized) on both brain response and appraisal of emotional cues based on stimuli valence. Moreover, significant effects were found as a function of valence (more right response to negative stimuli; more left response to positive stimuli) during emotion processing. Therefore, resting state may be considered a predictive marker of the successive cortical responsiveness to emotions. The significance of resting condition for emotional behavior was discussed. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  13. Annihilation of antiproton on deuteron at rest

    International Nuclear Information System (INIS)

    Grach, I.; Shmatikov, M.

    1982-01-01

    The system of Faddeev equations for amplitudes of anti pD iteraction at rest accounting for higher partial anti NN waves is derived. From its solution the total and elastic anti pD cross sections are calculated. Predictions for the missing-mass spectrum in the anti pD annihilation are made. The P-wave anti NN states give small contribution to the anti pD cross section at rest, the theoretical value of the latter being less than the experimental cross section extrapolated to the threshold. Let us emphasize that the total anti pD cross section depending weakly on the radii of anti NN interactions is sensitive to the values of the anti NN scattering lengths. Experimental data for anti pD cross sections at rest can be obtained only by extrapolation procedure. Henceforth it is very important to investigate the anti pD interactions at low but non-zero momenta where the direct comparison to the experiment is possible [ru

  14. Stability of whole brain and regional network topology within and between resting and cognitive states.

    Science.gov (United States)

    Rzucidlo, Justyna K; Roseman, Paige L; Laurienti, Paul J; Dagenbach, Dale

    2013-01-01

    Graph-theory based analyses of resting state functional Magnetic Resonance Imaging (fMRI) data have been used to map the network organization of the brain. While numerous analyses of resting state brain organization exist, many questions remain unexplored. The present study examines the stability of findings based on this approach over repeated resting state and working memory state sessions within the same individuals. This allows assessment of stability of network topology within the same state for both rest and working memory, and between rest and working memory as well. fMRI scans were performed on five participants while at rest and while performing the 2-back working memory task five times each, with task state alternating while they were in the scanner. Voxel-based whole brain network analyses were performed on the resulting data along with analyses of functional connectivity in regions associated with resting state and working memory. Network topology was fairly stable across repeated sessions of the same task, but varied significantly between rest and working memory. In the whole brain analysis, local efficiency, Eloc, differed significantly between rest and working memory. Analyses of network statistics for the precuneus and dorsolateral prefrontal cortex revealed significant differences in degree as a function of task state for both regions and in local efficiency for the precuneus. Conversely, no significant differences were observed across repeated sessions of the same state. These findings suggest that network topology is fairly stable within individuals across time for the same state, but also fluid between states. Whole brain voxel-based network analyses may prove to be a valuable tool for exploring how functional connectivity changes in response to task demands.

  15. Stability of whole brain and regional network topology within and between resting and cognitive states.

    Directory of Open Access Journals (Sweden)

    Justyna K Rzucidlo

    Full Text Available BACKGROUND: Graph-theory based analyses of resting state functional Magnetic Resonance Imaging (fMRI data have been used to map the network organization of the brain. While numerous analyses of resting state brain organization exist, many questions remain unexplored. The present study examines the stability of findings based on this approach over repeated resting state and working memory state sessions within the same individuals. This allows assessment of stability of network topology within the same state for both rest and working memory, and between rest and working memory as well. METHODOLOGY/PRINCIPAL FINDINGS: fMRI scans were performed on five participants while at rest and while performing the 2-back working memory task five times each, with task state alternating while they were in the scanner. Voxel-based whole brain network analyses were performed on the resulting data along with analyses of functional connectivity in regions associated with resting state and working memory. Network topology was fairly stable across repeated sessions of the same task, but varied significantly between rest and working memory. In the whole brain analysis, local efficiency, Eloc, differed significantly between rest and working memory. Analyses of network statistics for the precuneus and dorsolateral prefrontal cortex revealed significant differences in degree as a function of task state for both regions and in local efficiency for the precuneus. Conversely, no significant differences were observed across repeated sessions of the same state. CONCLUSIONS/SIGNIFICANCE: These findings suggest that network topology is fairly stable within individuals across time for the same state, but also fluid between states. Whole brain voxel-based network analyses may prove to be a valuable tool for exploring how functional connectivity changes in response to task demands.

  16. Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells.

    Directory of Open Access Journals (Sweden)

    Kara G Lassen

    2006-07-01

    Full Text Available HIV-1 latency in resting CD4+ T cells represents a major barrier to virus eradication in patients on highly active antiretroviral therapy (HAART. We describe here a novel post-transcriptional block in HIV-1 gene expression in resting CD4+ T cells from patients on HAART. This block involves the aberrant localization of multiply spliced (MS HIV-1 RNAs encoding the critical positive regulators Tat and Rev. Although these RNAs had no previously described export defect, we show that they exhibit strict nuclear localization in resting CD4+ T cells from patients on HAART. Overexpression of the transcriptional activator Tat from non-HIV vectors allowed virus production in these cells. Thus, the nuclear retention of MS HIV-1 RNA interrupts a positive feedback loop and contributes to the non-productive nature of infection of resting CD4+ T cells. To define the mechanism of nuclear retention, proteomic analysis was used to identify proteins that bind MS HIV-1 RNA. Polypyrimidine tract binding protein (PTB was identified as an HIV-1 RNA-binding protein differentially expressed in resting and activated CD4+ T cells. Overexpression of PTB in resting CD4+ T cells from patients on HAART allowed cytoplasmic accumulation of HIV-1 RNAs. PTB overexpression also induced virus production by resting CD4+ T cells. Virus culture experiments showed that overexpression of PTB in resting CD4+ T cells from patients on HAART allowed release of replication-competent virus, while preserving a resting cellular phenotype. Whether through effects on RNA export or another mechanism, the ability of PTB to reverse latency without inducing cellular activation is a result with therapeutic implications.

  17. Comparison of continuously acquired resting state and extracted analogues from active tasks.

    Science.gov (United States)

    Ganger, Sebastian; Hahn, Andreas; Küblböck, Martin; Kranz, Georg S; Spies, Marie; Vanicek, Thomas; Seiger, René; Sladky, Ronald; Windischberger, Christian; Kasper, Siegfried; Lanzenberger, Rupert

    2015-10-01

    Functional connectivity analysis of brain networks has become an important tool for investigation of human brain function. Although functional connectivity computations are usually based on resting-state data, the application to task-specific fMRI has received growing attention. Three major methods for extraction of resting-state data from task-related signal have been proposed (1) usage of unmanipulated task data for functional connectivity; (2) regression against task effects, subsequently using the residuals; and (3) concatenation of baseline blocks located in-between task blocks. Despite widespread application in current research, consensus on which method best resembles resting-state seems to be missing. We, therefore, evaluated these techniques in a sample of 26 healthy controls measured at 7 Tesla. In addition to continuous resting-state, two different task paradigms were assessed (emotion discrimination and right finger-tapping) and five well-described networks were analyzed (default mode, thalamus, cuneus, sensorimotor, and auditory). Investigating the similarity to continuous resting-state (Dice, Intraclass correlation coefficient (ICC), R(2) ) showed that regression against task effects yields functional connectivity networks most alike to resting-state. However, all methods exhibited significant differences when compared to continuous resting-state and similarity metrics were lower than test-retest of two resting-state scans. Omitting global signal regression did not change these findings. Visually, the networks are highly similar, but through further investigation marked differences can be found. Therefore, our data does not support referring to resting-state when extracting signals from task designs, although functional connectivity computed from task-specific data may indeed yield interesting information. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

  18. Analysis of microvascular perfusion with multi-dimensional complete ensemble empirical mode decomposition with adaptive noise algorithm: Processing of laser speckle contrast images recorded in healthy subjects, at rest and during acetylcholine stimulation.

    Science.gov (United States)

    Humeau-Heurtier, Anne; Marche, Pauline; Dubois, Severine; Mahe, Guillaume

    2015-01-01

    Laser speckle contrast imaging (LSCI) is a full-field imaging modality to monitor microvascular blood flow. It is able to give images with high temporal and spatial resolutions. However, when the skin is studied, the interpretation of the bidimensional data may be difficult. This is why an averaging of the perfusion values in regions of interest is often performed and the result is followed in time, reducing the data to monodimensional time series. In order to avoid such a procedure (that leads to a loss of the spatial resolution), we propose to extract patterns from LSCI data and to compare these patterns for two physiological states in healthy subjects: at rest and at the peak of acetylcholine-induced perfusion peak. For this purpose, the recent multi-dimensional complete ensemble empirical mode decomposition with adaptive noise (MCEEMDAN) algorithm is applied to LSCI data. The results show that the intrinsic mode functions and residue given by MCEEMDAN show different patterns for the two physiological states. The images, as bidimensional data, can therefore be processed to reveal microvascular perfusion patterns, hidden in the images themselves. This work is therefore a feasibility study before analyzing data in patients with microvascular dysfunctions.

  19. Resting-state brain activity in adult males who stutter.

    Directory of Open Access Journals (Sweden)

    Yun Xuan

    Full Text Available Although developmental stuttering has been extensively studied with structural and task-based functional magnetic resonance imaging (fMRI, few studies have focused on resting-state brain activity in this disorder. We investigated resting-state brain activity of stuttering subjects by analyzing the amplitude of low-frequency fluctuation (ALFF, region of interest (ROI-based functional connectivity (FC and independent component analysis (ICA-based FC. Forty-four adult males with developmental stuttering and 46 age-matched fluent male controls were scanned using resting-state fMRI. ALFF, ROI-based FCs and ICA-based FCs were compared between male stuttering subjects and fluent controls in a voxel-wise manner. Compared with fluent controls, stuttering subjects showed increased ALFF in left brain areas related to speech motor and auditory functions and bilateral prefrontal cortices related to cognitive control. However, stuttering subjects showed decreased ALFF in the left posterior language reception area and bilateral non-speech motor areas. ROI-based FC analysis revealed decreased FC between the posterior language area involved in the perception and decoding of sensory information and anterior brain area involved in the initiation of speech motor function, as well as increased FC within anterior or posterior speech- and language-associated areas and between the prefrontal areas and default-mode network (DMN in stuttering subjects. ICA showed that stuttering subjects had decreased FC in the DMN and increased FC in the sensorimotor network. Our findings support the concept that stuttering subjects have deficits in multiple functional systems (motor, language, auditory and DMN and in the connections between them.

  20. Gender Differences in Baroreflex Sensitivity after Bed Rest

    Science.gov (United States)

    Arzeno, Natalia M.; Stenger, M. B.; Ribeiro, L. C.; Lee, S. M.; Platts, S. H.

    2009-01-01

    Two potential contributing factors to post-spaceflight orthostatic intolerance are decreases in baroreflex sensitivity (BRS) and sympathetic nervous system response. The purpose of this study was to examine the shape of the BRS curve and sympathetic response to a wide range of blood pressures (BP) before and during 6 head-down bed rest (BR). METHODS: Normal volunteers were tested one day before BR (20M, 1 0F) and near BR days 30 (20M, 10F), 60 (16M, 8F), and 90 (1 0M, 5F). BP was pharmacologically manipulated by 10-min infusions of phenylephrine (PE) and sodium nitroprusside (SNP) at 3 increasing concentrations with a 20-min rest between PE and SNP. Electrocardiogram and continuous finger blood pressure were recorded. A blood sample was drawn at the end of each infusion to measure plasma norepinephrine levels. The spontaneous baroreflex slope (SBS), a measure of BRS, was calculated as the slope of a sequence of 3 or more beats in which the systolic BP (SBP) and following R-R interval (RR) both increased or decreased. The data included saturated responses at the upper but not the lower end of the BP range. Mean response curves were constructed using second-order mixed model analysis. Results are based on term significance in the models. RESULTS RR: RR was lower during BR than pre BR (pgenders were modeled by a linear response; compared to males, females had an attenuated (lower slope) RR response to changes in SBP (p=0.031). SBS: SBS vs SBP analysis showed a lower SBS during BR (pgender and BR. Not only do gender and BR baseline differences exist, but gender and BR also influence the slope and saturation of the BRS curves. Attenuated and saturating RR and SBS responses, as well as differences in baseline values, may contribute to the higher rates of orthostatic intolerance in women and after bed rest.