WorldWideScience

Sample records for responsive map kinase-like

  1. Wall-associated kinase-like polypeptide mediates nutritional status perception and response

    Science.gov (United States)

    Yang, Zhenbiao; Karr, Stephen

    2014-02-11

    The disclosure relates to methods for modulating plant growth and organogenesis using dominant-negative receptor-like kinases. The disclosure further provides a method for increasing plant yield relative to corresponding wild type plants comprising modulating the expression in a plant of a nucleic acid encoding a Wall-Associated Kinase-like 14 polypeptide or a homolog thereof, and selecting for plants having increased yield or growth on a nutrient deficient substrate.

  2. Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.

    Science.gov (United States)

    May-Dracka, Tricia L; Arduini, Robert; Bertolotti-Ciarlet, Andrea; Bhisetti, Govinda; Brickelmaier, Margot; Cahir-McFarland, Ellen; Enyedy, Istvan; Fontenot, Jason D; Hesson, Thomas; Little, Kevin; Lyssikatos, Joe; Marcotte, Douglas; McKee, Timothy; Murugan, Paramasivam; Patterson, Thomas; Peng, Hairuo; Rushe, Mia; Silvian, Laura; Spilker, Kerri; Wu, Ping; Xin, Zhili; Burkly, Linda C

    2018-06-01

    Germinal center kinase-like kinase (GLK, also known as MAP4K3) has been hypothesized to have an effect on key cellular activities, including inflammatory responses. GLK is required for activation of protein kinase C-θ (PKCθ) in T cells. Controlling the activity of T helper cell responses could be valuable for the treatment of autoimmune diseases. This approach circumvents previous unsuccessful approaches to target PKCθ directly. The use of structure based drug design, aided by the first crystal structure of GLK, led to the discovery of several inhibitors that demonstrate potent inhibition of GLK biochemically and in relevant cell lines. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. Mapping "Social Responsibility" in Science

    DEFF Research Database (Denmark)

    Horst, Maja; Glerup, Cecilie

    The paper investigates the discourse on social responsibility in science as it appears in academic journals. Through database searches a collection of more than 300 papers have been analysed in order to map their answers to the following three questions: - What is the central problem that threatens...... responsibility in science? - What are the central aspects of science or its relation to society that need to be regulated or changed? - What kinds of solutions are imagined and how are these solutions supposed to be put into place? On this basis the paper explores how different interpretations of the notion...... of social responsibility of science imply different forms of governance of and within science. The paper employs a Foucaldian discourse analysis to understand how a particular conceptualisation of responsibility implies a political rationality, i.e. a particular form of governance of science. The analysis...

  4. Mapping 'Social Responsibility' in Science

    DEFF Research Database (Denmark)

    Glerup, Cecilie; Horst, Maja

    2014-01-01

    This article employs the Foucauldian notion of ‘political rationality’ to map discussions and ideals about the responsibility of science toward society. By constructing and analyzing an archive of 263 journal papers, four political rationalities were identified: the Demarcation rationality, which......, which insists that responsible science should live up to public demands for innovation and democracy; and the Integration rationality, which advocates that science should be co-constructed with societal actors in order to be socially responsible. While each rationality is distinct, the article argues...... that all of them address the issue of a boundary (or integration) between science and society. Hence, it is not possible for scientists to avoid ‘a relationship’ with society. The political question is how this relationship is to be defined and regulated....

  5. Collaborative situational mapping during emergency response

    NARCIS (Netherlands)

    Gunawan, L.T.; Oomes, A.H.J.; Neerincx, M.; Brinkman, W.-P.; Alers, H.

    2009-01-01

    During emergency response, individuals observe only part of the picture, sharing of information is needed to get the required complete picture. The aim of our study is to get insight in the collaborative mapping process in order to derive requirements for a map-sharing tool. First, we analyzed the

  6. Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors.

    Science.gov (United States)

    Jhang, Cian-Ling; Huang, Tzyy-Nan; Hsueh, Yi-Ping; Liao, Wenlin

    2017-10-15

    Neurodevelopmental disorders frequently share common clinical features and appear high rate of comorbidity, such as those present in patients with attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD). While characterizing behavioral phenotypes in the mouse model of cyclin-dependent kinase-like 5 (CDKL5) disorder, a neurodevelopmental disorder caused by mutations in the X-linked gene encoding CDKL5, we found that these mice manifested behavioral phenotypes mimicking multiple key features of ASD, such as impaired social interaction and communication, as well as increased stereotypic digging behaviors. These mice also displayed hyper-locomotion, increased aggressiveness and impulsivity, plus deficits in motor and associative learning, resembling primary symptoms of ADHD. Through brain region-specific biochemical analysis, we uncovered that loss of CDKL5 disrupts dopamine synthesis and the expression of social communication-related key genes, such as forkhead-box P2 and mu-opioid receptor, in the corticostriatal circuit. Together, our findings support that CDKL5 plays a role in the comorbid features of autism and ADHD, and mice lacking CDKL5 may serve as an animal model to study the molecular and circuit mechanisms underlying autism-ADHD comorbidity. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  7. Critical Determinants of Substrate Recognition by Cyclin-Dependent Kinase-like 5 (CDKL5).

    Science.gov (United States)

    Katayama, Syouichi; Sueyoshi, Noriyuki; Kameshita, Isamu

    2015-05-19

    Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase known to be associated with X-linked neurodevelopmental disorders. In a previous study, we identified amphiphysin 1 (Amph1) as a potential substrate for CDKL5 and identified a single phosphorylation site at Ser-293. In this study, we investigated the molecular mechanisms of substrate recognition by CDKL5 using Amph1 as a model substrate. Amph1 served as an efficient CDKL5 substrate, whereas Amph2, a structurally related homologue of Amph1, was not phosphorylated by CDKL5. The sequence around the Amph1 phosphorylation site is RPR(293)SPSQ, while the corresponding sequence in Amph2 is IPK(332)SPSQ. To define the amino acid sequence specificity of the substrate, various point mutants of Amph1 and Amph2 were prepared and phosphorylated by CDKL5. Both Amph2(I329R) and Amph1 served as efficient CDKL5 substrates, but Amph1(R290I) did not, indicating that the arginyl residue at the P -3 position is critical for substrate recognition. With regard to prolyl residues around the phosphorylation site of Amph1, Pro-291 at the P -2 position, but not Pro-294 at the P +1 position, is indispensable for phosphorylation by CDKL5. Phosphorylation experiments using various deletion mutants of Amph1 revealed that the proline-rich domain (PRD) (amino acids 247-315) alone was not phosphorylated by CDKL5. In contrast, Amph1(247-385), which comprised the PRD and CLAP domains, served as an efficient CDKL5 substrate. These results, taken together, suggest that both the phosphorylation site sequence (RPXSX) and the CLAP domain structure in Amph1 play crucial roles in recognition and phosphorylation by CDKL5.

  8. Novel mutations in cyclin-dependent kinase-like 5 (CDKL5) gene in Indian cases of Rett syndrome.

    Science.gov (United States)

    Das, Dhanjit Kumar; Mehta, Bhakti; Menon, Shyla R; Raha, Sarbani; Udani, Vrajesh

    2013-03-01

    Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterized by a wide spectrum of clinical manifestations. Both the classic and atypical forms of Rett syndrome are primarily due to mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in patients with atypical Rett syndrome, X-linked infantile spasms sharing common features of generally early-onset seizures and mental retardation. CDKL5 is known as serine/threonine protein kinase 9 (STK9) and is mapped to the Xp22 region. It has a conserved serine/threonine kinase domain within its amino terminus and a large C-terminal region. Disease-causing mutations are distributed in both the amino terminal domain and in the large C-terminal domain. We have screened the CDKL5 gene in 44 patients with atypical Rett syndrome who had tested negative for MECP2 gene mutations and have identified 6 sequence variants, out of which three were novel and three known mutations. Two of these novel mutations p.V966I and p.A1011V were missense and p.H589H a silent mutation. Other known mutations identified were p.V999M, p.Q791P and p.T734A. Sequence homology for all the mutations revealed that the two mutations (p.Q791P and p.T734A) were conserved across species. This indicated the importance of these residues in structure and function of the protein. The damaging effects of these mutations were analysed in silico using PolyPhen-2 online software. The PolyPhen-2 scores of p.Q791P and p.T734A were 0.998 and 0.48, revealing that these mutations could be deleterious and might have potential functional effect. All other mutations had a low score suggesting that they might not alter the activity of CDKL5. We have also analysed the position of the mutations in the CDKL5 protein and found that all the mutations were present in the C-terminal domain of the protein. The C-terminal domain is required for

  9. Response variance in functional maps: neural darwinism revisited.

    Directory of Open Access Journals (Sweden)

    Hirokazu Takahashi

    Full Text Available The mechanisms by which functional maps and map plasticity contribute to cortical computation remain controversial. Recent studies have revisited the theory of neural Darwinism to interpret the learning-induced map plasticity and neuronal heterogeneity observed in the cortex. Here, we hypothesize that the Darwinian principle provides a substrate to explain the relationship between neuron heterogeneity and cortical functional maps. We demonstrate in the rat auditory cortex that the degree of response variance is closely correlated with the size of its representational area. Further, we show that the response variance within a given population is altered through training. These results suggest that larger representational areas may help to accommodate heterogeneous populations of neurons. Thus, functional maps and map plasticity are likely to play essential roles in Darwinian computation, serving as effective, but not absolutely necessary, structures to generate diverse response properties within a neural population.

  10. Response variance in functional maps: neural darwinism revisited.

    Science.gov (United States)

    Takahashi, Hirokazu; Yokota, Ryo; Kanzaki, Ryohei

    2013-01-01

    The mechanisms by which functional maps and map plasticity contribute to cortical computation remain controversial. Recent studies have revisited the theory of neural Darwinism to interpret the learning-induced map plasticity and neuronal heterogeneity observed in the cortex. Here, we hypothesize that the Darwinian principle provides a substrate to explain the relationship between neuron heterogeneity and cortical functional maps. We demonstrate in the rat auditory cortex that the degree of response variance is closely correlated with the size of its representational area. Further, we show that the response variance within a given population is altered through training. These results suggest that larger representational areas may help to accommodate heterogeneous populations of neurons. Thus, functional maps and map plasticity are likely to play essential roles in Darwinian computation, serving as effective, but not absolutely necessary, structures to generate diverse response properties within a neural population.

  11. Space Mapping With Adaptive Response Correction for Microwave Design Optimization

    DEFF Research Database (Denmark)

    Koziel, S.; Bandler, J.W.; Madsen, Kaj

    2009-01-01

    at which the term was calculated, as in the surrogate model optimization process. In this paper, an adaptive response correction scheme is presented to work in conjunction with space-mapping optimization algorithms. This technique is designed to alleviate the difficulties of the standard output space......Output space mapping is a technique introduced to enhance the robustness of the space-mapping optimization process in case the space-mapped coarse model cannot provide sufficient matching with the fine model. The technique often works very well; however, in some cases it fails. Especially...

  12. The arabidopsis wall associated kinase-like 10 gene encodes a functional guanylyl cyclase and is co-expressed with pathogen defense related genes

    KAUST Repository

    Meier, Stuart; Ruzvidzo, Oziniel; Morse, Monique; Donaldson, Lara; Kwezi, Lusisizwe; Gehring, Christoph A

    2010-01-01

    Background: Second messengers have a key role in linking environmental stimuli to physiological responses. One such messenger, guanosine 3?,5?-cyclic monophosphate (cGMP), has long been known to be an essential signaling molecule in many different physiological processes in higher plants, including biotic stress responses. To date, however, the guanylyl cyclase (GC) enzymes that catalyze the formation of cGMP from GTP have largely remained elusive in higher plants. Principal Findings: We have identified an Arabidopsis receptor type wall associated kinase-like molecule (AtWAKL10) as a candidate GC and provide experimental evidence to show that the intracellular domain of AtWAKL10431-700 can generate cGMP in vitro. Further, we also demonstrate that the molecule has kinase activity indicating that AtWAKL10 is a twin-domain catalytic protein. A co-expression and stimulus-specific expression analysis revealed that AtWAKL10 is consistently coexpressed with well characterized pathogen defense related genes and along with these genes is induced early and sharply in response to a range of pathogens and their elicitors. Conclusions: We demonstrate that AtWAKL10 is a twin-domain, kinase-GC signaling molecule that may function in biotic stress responses that are critically dependent on the second messenger cGMP. © 2010 Meier et al.

  13. The arabidopsis wall associated kinase-like 10 gene encodes a functional guanylyl cyclase and is co-expressed with pathogen defense related genes

    KAUST Repository

    Meier, Stuart

    2010-01-26

    Background: Second messengers have a key role in linking environmental stimuli to physiological responses. One such messenger, guanosine 3?,5?-cyclic monophosphate (cGMP), has long been known to be an essential signaling molecule in many different physiological processes in higher plants, including biotic stress responses. To date, however, the guanylyl cyclase (GC) enzymes that catalyze the formation of cGMP from GTP have largely remained elusive in higher plants. Principal Findings: We have identified an Arabidopsis receptor type wall associated kinase-like molecule (AtWAKL10) as a candidate GC and provide experimental evidence to show that the intracellular domain of AtWAKL10431-700 can generate cGMP in vitro. Further, we also demonstrate that the molecule has kinase activity indicating that AtWAKL10 is a twin-domain catalytic protein. A co-expression and stimulus-specific expression analysis revealed that AtWAKL10 is consistently coexpressed with well characterized pathogen defense related genes and along with these genes is induced early and sharply in response to a range of pathogens and their elicitors. Conclusions: We demonstrate that AtWAKL10 is a twin-domain, kinase-GC signaling molecule that may function in biotic stress responses that are critically dependent on the second messenger cGMP. © 2010 Meier et al.

  14. Sensitivity mapping for oil spill response. V. 1

    International Nuclear Information System (INIS)

    1997-01-01

    Making and updating sensitivity maps are key activities in the oil spill contingency planning process. These maps convey essential information to spill responders by showing where the different coastal resources are, and by indicating environmentally sensitive areas. The making of a map involves assembling information on resources and deciding on what guidelines for spill response should be included, through consultation with relevant organizations. This can be done regardless of whether or not the benefits of computerized Geographic Information Systems and databases are available. Uses of sensitivity maps range from planning practical site-specific shore protection and clean-up to strategic planning for large remote areas. This report provides information and guidelines on different map types, categories of information to be included, and symbols, with reference to the different users and their requirements. (UK)

  15. An integrated approach to shoreline mapping for spill response planning

    International Nuclear Information System (INIS)

    Owens, E.H.; LeBlanc, S.R.; Percy, R.J.

    1996-01-01

    A desktop mapping package was introduced which has the capability to provide consistent and standardized application of mapping and data collection/generation techniques. Its application in oil spill cleanup was discussed. The data base can be updated easily as new information becomes available. This provides a response team with access to a wide range of information that would otherwise be difficult to obtain. Standard terms and definitions and shoreline segmentation procedures are part of the system to describe the shore-zone character and shore-zone oiling conditions. The program that is in place for Atlantic Canada involves the integration of (1) Environment Canada's SCAT methodology in pre-spill data generation, (2) shoreline segmentation, (3) response management by objectives, (4) Environment Canada's national sensitivity mapping program, and (5) Environment Canada's field guide for the protection and treatment of oiled shorelines. 7 refs., 6 figs

  16. Phosphoproteomic insights into processes influenced by the kinase-like protein DIA1/C3orf58

    Directory of Open Access Journals (Sweden)

    Agnieszka Hareza

    2018-04-01

    Full Text Available Many kinases are still ‘orphans,’ which means knowledge about their substrates, and often also about the processes they regulate, is lacking. Here, DIA1/C3orf58, a member of a novel predicted kinase-like family, is shown to be present in the endoplasmic reticulum and to influence trafficking via the secretory pathway. Subsequently, DIA1 is subjected to phosphoproteomics analysis to cast light on its signalling pathways. A liquid chromatography–tandem mass spectrometry proteomic approach with phosphopeptide enrichment is applied to membrane fractions of DIA1-overexpressing and control HEK293T cells, and phosphosites dependent on the presence of DIA1 are elucidated. Most of these phosphosites belonged to CK2- and proline-directed kinase types. In parallel, the proteomics of proteins immunoprecipitated with DIA1 reported its probable interactors. This pilot study provides the basis for deeper studies of DIA1 signalling.

  17. Phosphoproteomic insights into processes influenced by the kinase-like protein DIA1/C3orf58.

    Science.gov (United States)

    Hareza, Agnieszka; Bakun, Magda; Świderska, Bianka; Dudkiewicz, Małgorzata; Koscielny, Alicja; Bajur, Anna; Jaworski, Jacek; Dadlez, Michał; Pawłowski, Krzysztof

    2018-01-01

    Many kinases are still 'orphans,' which means knowledge about their substrates, and often also about the processes they regulate, is lacking. Here, DIA1/C3orf58, a member of a novel predicted kinase-like family, is shown to be present in the endoplasmic reticulum and to influence trafficking via the secretory pathway. Subsequently, DIA1 is subjected to phosphoproteomics analysis to cast light on its signalling pathways. A liquid chromatography-tandem mass spectrometry proteomic approach with phosphopeptide enrichment is applied to membrane fractions of DIA1-overexpressing and control HEK293T cells, and phosphosites dependent on the presence of DIA1 are elucidated. Most of these phosphosites belonged to CK2- and proline-directed kinase types. In parallel, the proteomics of proteins immunoprecipitated with DIA1 reported its probable interactors. This pilot study provides the basis for deeper studies of DIA1 signalling.

  18. SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum.

    Science.gov (United States)

    Abdi, Abdirahman; Eschenlauer, Sylvain; Reininger, Luc; Doerig, Christian

    2010-10-01

    Over the last decade, several protein kinases inhibitors have reached the market for cancer chemotherapy. The kinomes of pathogens represent potentially attractive targets in infectious diseases. The functions of the majority of protein kinases of Plasmodium falciparum, the parasitic protist responsible for the most virulent form of human malaria, remain unknown. Here we present a thorough characterisation of PfTKL3 (PF13_0258), an enzyme that belongs to the tyrosine kinase-like kinase (TKL) group. We demonstrate by reverse genetics that PfTKL3 is essential for asexual parasite proliferation in human erythrocytes. PfTKL3 is expressed in both asexual and gametocytes stages, and in the latter the protein co-localises with cytoskeleton microtubules. Recombinant PfTKL3 displays in vitro autophosphorylation activity and is able to phosphorylate exogenous substrates, and both activities are dramatically dependent on the presence of an N-terminal "sterile alpha-motif" domain. This study identifies PfTKL3 as a validated drug target amenable to high-throughput screening.

  19. 31P NMR Spectroscopy Revealed Adenylate kinase-like Activity and Phosphotransferase-like Activity from F1-ATPase of Escherichia coli

    International Nuclear Information System (INIS)

    Kim, Hyun Won

    2011-01-01

    Adenylate kinase-like activity and phosphotransferase-like activity from F 1 -ATPase of Escherichia coli was revealed by 31 P NMR spectroscopy. Incubation of F 1 -ATPase with ADP in the presence of Mg 2+ shows the appearance of 31 P resonances from AMP and Pi, suggesting generation of AMP and ATP by adenylate kinase-like activity and the subsequent hydrolysis to Pi. Incubation of F1-ATPase with ADP in the presence of methanol shows additional peak from methyl phosphate, suggesting phosphotransferase-like activity of F 1 -ATPase. Both adenylate kinase-like activity and phosphotransferase-like activity has not been reported from F 1 -ATPase of Escherichia coli. 31 P NMR could be a valuable tool for the investigation of phosphorous related enzyme

  20. Entrepreneurial dynamics and social responsibility: mapping an expanded intellectual territory

    OpenAIRE

    Blundel, Richard; Spence, Laura J.

    2009-01-01

    Objectives: (1) To provide a constructive critique of the interface between the entrepreneurial growth dynamics research and social responsibility literatures; (2) to explore opportunities for making new connections between these literatures in order to address substantive ‘gaps’ in research and policy-making ; (3) to map the broader intellectual territory implied by this critique; (4) to outline a tentative research agenda. \\ud Prior work: The paper draws on two main strands of research: ent...

  1. Sexually Monomorphic Maps and Dimorphic Responses in Rat Genital Cortex.

    Science.gov (United States)

    Lenschow, Constanze; Copley, Sean; Gardiner, Jayne M; Talbot, Zoe N; Vitenzon, Ariel; Brecht, Michael

    2016-01-11

    Mammalian external genitals show sexual dimorphism [1, 2] and can change size and shape upon sexual arousal. Genitals feature prominently in the oldest pieces of figural art [3] and phallic depictions of penises informed psychoanalytic thought about sexuality [4, 5]. Despite this longstanding interest, the neural representations of genitals are still poorly understood [6]. In somatosensory cortex specifically, many studies did not detect any cortical representation of genitals [7-9]. Studies in humans debate whether genitals are represented displaced below the foot of the cortical body map [10-12] or whether they are represented somatotopically [13-15]. We wondered what a high-resolution mapping of genital representations might tell us about the sexual differentiation of the mammalian brain. We identified genital responses in rat somatosensory cortex in a region previously assigned as arm/leg cortex. Genital responses were more common in males than in females. Despite such response dimorphism, we observed a stunning anatomical monomorphism of cortical penis and clitoris input maps revealed by cytochrome-oxidase-staining of cortical layer 4. Genital representations were somatotopic and bilaterally symmetric, and their relative size increased markedly during puberty. Size, shape, and erect posture give the cortical penis representation a phallic appearance pointing to a role in sexually aroused states. Cortical genital neurons showed unusual multi-body-part responses and sexually dimorphic receptive fields. Specifically, genital neurons were co-activated by distant body regions, which are touched during mounting in the respective sex. Genital maps indicate a deep homology of penis and clitoris representations in line with a fundamentally bi-sexual layout [16] of the vertebrate brain. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Linear response formula for piecewise expanding unimodal maps

    International Nuclear Information System (INIS)

    Baladi, Viviane; Smania, Daniel

    2008-01-01

    The average R(t) = ∫φdμ t of a smooth function ψ with respect to the SRB measure μ t of a smooth one-parameter family f t of piecewise expanding interval maps is not always Lipschitz (Baladi 2007 Commun. Math. Phys. 275 839–59, Mazzolena 2007 Master's Thesis Rome 2, Tor Vergata). We prove that if f t is tangent to the topological class of f, and if ∂ t f t | t=0 = X circle f, then R(t) is differentiable at zero, and R'(0) coincides with the resummation proposed (Baladi 2007) of the (a priori divergent) series given by Ruelle's conjecture. In fact, we show that t map μ t is differentiable within Radon measures. Linear response is violated if and only if f t is transversal to the topological class of f

  3. Mapping long-term wetland response to climate

    Science.gov (United States)

    Zhou, Q.; Gallant, A.; Rover, J.

    2016-12-01

    Wetlands provide unique feeding and breeding habitat for numerous waterfowl species. The distribution of wetlands has been considerably changed due to agricultural land conversion and hydrologic modification. Climate change may further impact wetlands through altered moisture regimes. This study characterized long-term variation in wetland conditions by using dense time series from all available Landsat data from 1985 to 2014. We extracted harmonic frequencies from 30 years to two years to delineate the long-term variation in all seven Landsat bands. A cluster analysis and unsupervised classification then enabled us to map different classes of wetland response. We demonstrated the method in the Prairie Pothole Region in North Dakota.

  4. Creating a conceptual hydrological soil response map for the ...

    African Journals Online (AJOL)

    2014-03-03

    Mar 3, 2014 ... a digital soil mapping (DSM) approach to soil mapping can speed up the mapping process and thereby extend soil map use in the field of ... This research uses an expert-knowledge DSM approach to create a soil map for Stevenson Hamilton .... the different bands of the Landsat and SPOT 5 images.

  5. Creating a conceptual hydrological soil response map for the ...

    African Journals Online (AJOL)

    The use of a digital soil mapping (DSM) approach to soil mapping can speed up the mapping process and thereby extend soil map use in the field of hydrology. This research uses an expert-knowledge DSM approach to create a soil map for Stevenson Hamilton Research Supersite within the Kruger National Park, South ...

  6. Linear response formula for piecewise expanding unimodal maps

    Science.gov (United States)

    Baladi, Viviane; Smania, Daniel

    2008-04-01

    The average R(t)=\\int \\varphi\\,\\rmd \\mu_t of a smooth function phiv with respect to the SRB measure μt of a smooth one-parameter family ft of piecewise expanding interval maps is not always Lipschitz (Baladi 2007 Commun. Math. Phys. 275 839-59, Mazzolena 2007 Master's Thesis Rome 2, Tor Vergata). We prove that if ft is tangent to the topological class of f, and if ∂t ft|t = 0 = X circle f, then R(t) is differentiable at zero, and R'(0) coincides with the resummation proposed (Baladi 2007) of the (a priori divergent) series \\sum_{n=0}^\\infty \\int X(y) \\partial_y (\\varphi \\circ f^n)(y)\\,\\rmd \\mu_0(y) given by Ruelle's conjecture. In fact, we show that t map μt is differentiable within Radon measures. Linear response is violated if and only if ft is transversal to the topological class of f.

  7. Mapping neighborhood scale survey responses with uncertainty metrics

    Directory of Open Access Journals (Sweden)

    Charles Robert Ehlschlaeger

    2016-12-01

    Full Text Available This paper presents a methodology of mapping population-centric social, infrastructural, and environmental metrics at neighborhood scale. This methodology extends traditional survey analysis methods to create cartographic products useful in agent-based modeling and geographic information analysis. It utilizes and synthesizes survey microdata, sub-upazila attributes, land use information, and ground truth locations of attributes to create neighborhood scale multi-attribute maps. Monte Carlo methods are employed to combine any number of survey responses to stochastically weight survey cases and to simulate survey cases' locations in a study area. Through such Monte Carlo methods, known errors from each of the input sources can be retained. By keeping individual survey cases as the atomic unit of data representation, this methodology ensures that important covariates are retained and that ecological inference fallacy is eliminated. These techniques are demonstrated with a case study from the Chittagong Division in Bangladesh. The results provide a population-centric understanding of many social, infrastructural, and environmental metrics desired in humanitarian aid and disaster relief planning and operations wherever long term familiarity is lacking. Of critical importance is that the resulting products have easy to use explicit representation of the errors and uncertainties of each of the input sources via the automatically generated summary statistics created at the application's geographic scale.

  8. Detection and Characterization of Single-Trial fMRI BOLD Responses : Paradigm Free Mapping

    NARCIS (Netherlands)

    Gaudes, Cesar Caballero; Petridou, Natalia; Dryden, Ian L.; Bai, Li; Francis, Susan T.; Gowland, Penny A.

    This work presents a novel method of mapping the brain's response to single stimuli in space and time without prior knowledge of the paradigm timing: paradigm free mapping (PFM). This method is based on deconvolution of the hemodynamic response from the voxel time series assuming a linear response

  9. IRIS Responsiveness to Generation IV Road-map Goals

    International Nuclear Information System (INIS)

    Carelli, M.D.; Paramonov, D.V.; Petrovic, B.

    2002-01-01

    The DOE Generation IV road-map process is in its second and final year. Almost one hundred concepts submitted from all over the world have been reviewed against the Generation IV goals of resources sustainability; safety and reliability; and, economics. Advanced LWRs are taken as the reference point. IRIS (International Reactor Innovative and Secure), a 100-335 MWe integral light water reactor being developed by a vast international consortium led by Westinghouse, is one on the concepts being considered in the road-map and is perhaps the most visible representative of the concept set known as Integral Primary System Reactors (IPSR). This paper presents how IRIS satisfies the prescribed goals. The first goal of resource sustainability includes criteria like utilization of fuel resources, amount and toxicity of waste produced, environmental impact, proliferation and sabotage resistance. As a thermal reactor IRIS does not have the same fuel utilization as fast reactors. However, it has a significant flexibility in fuel cycles as it is designed to utilize either UO 2 or MOX with straight burn cycles of 4 to 10 years, depending on the fissile content. High discharge burnup and Pu recycling result in good fuel utilization and lower waste; IRIS has also attractive proliferation resistance characteristics, due to the reduced accessibility of the fuel. The safety and reliability goal include reliability, workers' exposure, robust safety features, models with well characterized uncertainty, source term and mechanisms of energy release, robust mitigation of accidents. IRIS is significantly better than advanced LWRs because of its safety by design which eliminates a variety of accidents such as LOCAs, its containment vessel coupled design which maintains the core safely covered during the accident sequences, its design simplification features such as no (or reduced) soluble boron, internal shielding and four-year refueling/maintenance interval which significantly reduce

  10. Validity and Responsiveness of Concept Map Assessment Scores in Physical Education

    Science.gov (United States)

    Lee, Yun Soo; Jang, Yongkyu; Kang, Minsoo

    2015-01-01

    Concept map assessment has been applied to many education areas to measure students' knowledge structure. However, the proper and valid use of concept map assessment has not been examined in physical education. The purpose of this study was to evaluate the evidence of validity and responsiveness of the concept map assessment scores in physical…

  11. Parametric Response Maps of Perfusion MRI May Identify Recurrent Glioblastomas Responsive to Bevacizumab and Irinotecan

    Science.gov (United States)

    Aquino, Domenico; Cuppini, Lucia; Anghileri, Elena; Finocchiaro, Gaetano; Bruzzone, Maria Grazia; Eoli, Marica

    2014-01-01

    Background Perfusion weighted imaging (PWI) can be used to measure key aspects of tumor vascularity in vivo and recent studies suggest that perfusion imaging may be useful in the early assessment of response to angiogenesis inhibitors. Aim of this work is to compare Parametric Response Maps (PRMs) with the Region Of Interest (ROI) approach in the analysis of tumor changes induced by bevacizumab and irinotecan in recurrent glioblastomas (rGBM), and to evaluate if changes in tumor blood volume measured by perfusion MRI may predict clinical outcome. Methods 42 rGBM patients with KPS ≥50 were treated until progression, as defined by MRI with RANO criteria. Relative cerebral blood volume (rCBV) variation after 8 weeks of treatment was calculated through semi-automatic ROI placement in the same anatomic region as in baseline. Alternatively, rCBV variations with respect to baseline were calculated into the evolving tumor region using a voxel-by-voxel difference. PRMs were created showing where rCBV significantly increased, decreased or remained unchanged. Results An increased blood volume in PRM (PRMCBV+) higher than 18% (first quartile) after 8 weeks of treatment was associated with increased progression free survival (PFS; 24 versus 13 weeks, p = 0.045) and overall survival (OS; 38 versus 25 weeks, p = 0.016). After 8 weeks of treatment ROI analysis showed that mean rCBV remained elevated in non responsive patients (4.8±0.9 versus 5.1±1.2, p = 0.38), whereas decreased in responsive patients (4.2±1.3 versus 3.8±1.6 p = 0.04), and re-increased progressively when patients approached tumor progression. Conclusions Our data suggest that PRMs can provide an early marker of response to antiangiogenic treatment and warrant further confirmation in a larger cohort of GBM patients. PMID:24675671

  12. Lower Colorado River Geographic Response Plan Web Mapping Service, Region 9, 2012, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — This map service is comprised of data related to Geographic Response Plans (GRPs) for the Lower Colorado River. Data layers were obtained from nationwide GIS...

  13. Parametric Response Mapping as an Indicator of Bronchiolitis Obliterans Syndrome after Hematopoietic Stem Cell Transplantation

    NARCIS (Netherlands)

    Galban, Craig J.; Boes, Jennifer L.; Bule, Maria; Kitko, Carrie L.; Couriel, Daniel R.; Johnson, Timothy D.; Lama, Vihba; Telenga, Eef D.; van den Berge, Maarten; Rehemtulla, Alnawaz; Kazerooni, Ella A.; Ponkowski, Michael J.; Ross, Brian D.; Yanik, Gregory A.

    2014-01-01

    The management of bronchiolitis obliterans syndrome (BOS) after hematopoietic cell transplantation presents many challenges, both diagnostically and therapeutically. We developed a computed tomography (CT) voxel-wise methodology termed parametric response mapping (PRM) that quantifies normal

  14. Proteomic Mapping of the Immune Response to Gluten in Children with Autism

    Science.gov (United States)

    2015-10-01

    AWARD NUMBER: W81XWH-14-1-0293 TITLE: Proteomic Mapping of the Immune Response to Gluten in Children with Autism PRINCIPAL INVESTIGATOR...Sep 2014 – 29 Sep 2015 4. TITLE AND SUBTITLE Proteomic Mapping of the Immune Response to Gluten in Children with Autism 5a. CONTRACT NUMBER 5b. GRANT...gastrointestinal (GI) symptoms and defects in GI function in the context of autism . Our newly published data indicate that children with autism exhibit

  15. Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein

    International Nuclear Information System (INIS)

    Inagaki, Yuichi; Mitsutake, Susumu; Igarashi, Yasuyuki

    2006-01-01

    Retinitis pigmentosa (RP) is a genetically heterogeneous disease characterized by degeneration of the retina. A mutation in a new ceramide kinase (CERK) homologous gene, named CERK-like protein (CERKL), was found to cause autosomal recessive retinitis pigmentosa (RP26). Here, we show a point mutation of one of two putative nuclear localization signal (NLS) sequences inhibited the nuclear localization of the protein. Furthermore, the tetra-GFP-tagged NLS, which cannot passively enter the nucleus, was observed not only in the nucleus but also in the nucleolus. Our results provide First evidence of the active nuclear import of CERKL and suggest that the identified NLS might be responsible for nucleolar retention of the protein. As recent studies have shown other RP-related proteins are localized in the nucleus or the nucleolus, our identification of NLS in CERKL suggests that CERKL likely plays important roles for retinal functions in the nucleus and the nucleolus

  16. Cellular and humoral immune responses in sheep vaccinated with candidate antigens MAP2698c and MAP3567 from Mycobacterium avium subspecies paratuberculosis

    Science.gov (United States)

    Gurung, Ratna B.; Purdie, Auriol C.; Whittington, Richard J.; Begg, Douglas J.

    2014-01-01

    Control of Johne's disease, caused by Mycobacterium avium subspecies paratuberculosis (MAP) in ruminants using commercially available vaccine reduces production losses, mortality, fecal shedding and histopathological lesions but does not provide complete protection from infection and interferes with serological diagnosis of Johne's disease and bovine tuberculosis. At this time no recombinant antigens have been found to provide superior protection compared to whole killed or live-attenuated MAP vaccines. Therefore, there is a need to evaluate more candidate MAP antigens. In this study recombinant MAP antigens MAP2698c and MAP3567 were formulated with four different MONTANIDE™ (ISA 50V2, 61VG, 71VG, and 201VG) adjuvants and evaluated for their ability to produce specific immune responses in vaccinated sheep. The cellular immune response was measured with an interferon-gamma (IFN-γ) release assay and the humoral immune response was measured by antibody detection enzyme linked immunosorbent assay. Recombinant vaccine formulation with the antigen MAP2698c and MONTANIDE™ ISA 201VG adjuvant produced strong whole-MAP as well as MAP2698c-specific IFN-γ responses in a high proportion of the vaccinated sheep. The formulation caused less severe injection site lesions in comparison to other formulations. The findings from this study suggest that the MAP2698c + 201VG should be evaluated in a challenge trial to determine the efficacy of this vaccine candidate. PMID:25077074

  17. Mapping the Obama administration's response to the Arab Spring

    Directory of Open Access Journals (Sweden)

    Maria do Céu de Pinho Ferreira Pinto

    2012-12-01

    Full Text Available When the Arab Spring broke out, the United States was in a quandary over how to handle the crisis in its attempt to balance its moral obligations and ideals without undercutting its strategic interests and those of its close allies. Flaws in US diplomatic approach have contributed to one of the most serious foreign policy crisis for a US administration to date with consequential upheaval and erosion of the US-built balance of power. The reactions and policy responses of the Obama administration highlight the difficulties in grasping with the new reality in the Middle East and in enunciating a policy platform that could combine American interests and values.

  18. A novel mutation in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene associated with a severe Rett phenotype.

    Science.gov (United States)

    Sprovieri, T; Conforti, F L; Fiumara, A; Mazzei, R; Ungaro, C; Citrigno, L; Muglia, M; Arena, A; Quattrone, A

    2009-02-15

    Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have recently been reported in patients with severe neurodevelopmental disorder characterized by early-onset seizures, infantile spasms, severe psychomotor impairment and very recently, in patients with Rett syndrome (RTT)-like phenotype. Although the involvement of CDKL5 in specific biological pathways and its neurodevelopmental role have not been completely elucidated, the CDKL5 appears to be physiologically related to the MECP2 gene. Here we report on the clinical and CDKL5 molecular investigation in a very unusual RTT case, with severe, early-neurological involvement in which we have shown in a previous report, a novel P388S MECP2 mutation [Conforti et al. (2003); Am J Med Genet A 117A: 184-187]. The patient has had severe psychomotor delay since the first month of life and infantile spasms since age 5 months. Moreover, at age 5 years the patient suddenly presented with renal failure. The severe pattern of symptoms in our patient, similar to a CDKL5 phenotype, prompted us to perform an analysis of the CDKL5, which revealed a novel missense mutation never previously described. The X-inactivation assay was non-informative. In conclusion, this report reinforces the observation that the CDKL5 phenotype overlaps with RTT and that CDKL5 analysis is recommended in patients with a seizure disorder commencing during the first months of life.

  19. A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain.

    Science.gov (United States)

    Williamson, Sarah L; Giudici, Laura; Kilstrup-Nielsen, Charlotte; Gold, Wendy; Pelka, Gregory J; Tam, Patrick P L; Grimm, Andrew; Prodi, Dionigio; Landsberger, Nicoletta; Christodoulou, John

    2012-02-01

    The X-linked cyclin-dependent kinase-like 5 (CDKL5) gene is an important molecular determinant of early-onset intractable seizures with infantile spasms and Rett syndrome-like phenotype. The gene encodes a kinase that may influence components of molecular pathways associated with MeCP2. In humans there are two previously reported splice variants that differ in the 5' untranslated exons and produce the same 115 kDa protein. Furthermore, very recently, a novel transcript including a novel exon (16b) has been described. By aligning both the human and mouse CDKL5 proteins to the orthologs of other species, we identified a theoretical 107 kDa isoform with an alternative C-terminus that terminates in intron 18. In human brain and all other tissues investigated except the testis, this novel isoform is the major CDKL5 transcript. The detailed characterisation of this novel isoform of CDKL5 reveals functional and subcellular localisation attributes that overlap greatly, but not completely, with that of the previously studied human CDKL5 protein. Considering its predominant expression in the human and mouse brain, we believe that this novel isoform is likely to be of primary pathogenic importance in human diseases associated with CDKL5 deficiency, and suggest that screening of the related intronic sequence should be included in the molecular genetic analyses of patients with a suggestive clinical phenotype.

  20. Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region.

    Science.gov (United States)

    Witte, Florian; Chan, Danny; Economides, Aris N; Mundlos, Stefan; Stricker, Sigmar

    2010-08-10

    Elongation of the digit rays resulting in the formation of a defined number of phalanges is a process poorly understood in mammals, whereas in the chicken distal mesenchymal bone morphogenetic protein (BMP) signaling in the so-called phalanx-forming region (PFR) or digit crescent (DC) seems to be involved. The human brachydactylies (BDs) are inheritable conditions characterized by variable degrees of digit shortening, thus providing an ideal model to analyze the development and elongation of phalanges. We used a mouse model for BDB1 (Ror2(W749X/W749X)) lacking middle phalanges and show that a signaling center corresponding to the chick PFR exists in the mouse, which is diminished in BDB1 mice. This resulted in a strongly impaired elongation of the digit condensations due to reduced chondrogenic commitment of undifferentiated distal mesenchymal cells. We further show that a similar BMP-based mechanism accounts for digit shortening in a mouse model for the closely related condition BDA1 (Ihh(E95K/E95K)), altogether indicating the functional significance of the PFR in mammals. Genetic interaction experiments as well as pathway analysis in BDB1 mice suggest that Indian hedgehog and WNT/beta-catenin signaling, which we show is inhibited by receptor tyrosine kinase-like orphan receptor 2 (ROR2) in distal limb mesenchyme, are acting upstream of BMP signaling in the PFR.

  1. Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family.

    Science.gov (United States)

    Reidenbach, Andrew G; Kemmerer, Zachary A; Aydin, Deniz; Jochem, Adam; McDevitt, Molly T; Hutchins, Paul D; Stark, Jaime L; Stefely, Jonathan A; Reddy, Thiru; Hebert, Alex S; Wilkerson, Emily M; Johnson, Isabel E; Bingman, Craig A; Markley, John L; Coon, Joshua J; Dal Peraro, Matteo; Pagliarini, David J

    2018-02-15

    Human COQ8A (ADCK3) and Saccharomyces cerevisiae Coq8p (collectively COQ8) are UbiB family proteins essential for mitochondrial coenzyme Q (CoQ) biosynthesis. However, the biochemical activity of COQ8 and its direct role in CoQ production remain unclear, in part due to lack of known endogenous regulators of COQ8 function and of effective small molecules for probing its activity in vivo. Here, we demonstrate that COQ8 possesses evolutionarily conserved ATPase activity that is activated by binding to membranes containing cardiolipin and by phenolic compounds that resemble CoQ pathway intermediates. We further create an analog-sensitive version of Coq8p and reveal that acute chemical inhibition of its endogenous activity in yeast is sufficient to cause respiratory deficiency concomitant with CoQ depletion. Collectively, this work defines lipid and small-molecule modulators of an ancient family of atypical kinase-like proteins and establishes a chemical genetic system for further exploring the mechanistic role of COQ8 in CoQ biosynthesis. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Adaptation of the MapMan ontology to biotic stress responses: application in solanaceous species

    Directory of Open Access Journals (Sweden)

    Stitt Mark

    2007-09-01

    Full Text Available Abstract Background The results of transcriptome microarray analysis are usually presented as a list of differentially expressed genes. As these lists can be long, it is hard to interpret the desired experimental treatment effect on the physiology of analysed tissue, e.g. via selected metabolic or other pathways. For some organisms, gene ontologies and data visualization software have been implemented to overcome this problem, whereas for others, software adaptation is yet to be done. Results We present the classification of tentative potato contigs from the potato gene index (StGI available from Dana-Farber Cancer Institute (DFCI into the MapMan ontology to enable the application of the MapMan family of tools to potato microarrays. Special attention has been focused on mapping genes that could not be annotated based on similarity to Arabidopsis genes alone, thus possibly representing genes unique for potato. 97 such genes were classified into functional BINs (i.e. functional classes after manual annotation. A new pathway, focusing on biotic stress responses, has been added and can be used for all other organisms for which mappings have been done. The BIN representation on the potato 10 k cDNA microarray, in comparison with all putative potato gene sequences, has been tested. The functionality of the prepared potato mapping was validated with experimental data on plant response to viral infection. In total 43,408 unigenes were mapped into 35 corresponding BINs. Conclusion The potato mappings can be used to visualize up-to-date, publicly available, expressed sequence tags (ESTs and other sequences from GenBank, in combination with metabolic pathways. Further expert work on potato annotations will be needed with the ongoing EST and genome sequencing of potato. The current MapMan application for potato is directly applicable for analysis of data obtained on potato 10 k cDNA microarray by TIGR (The Institute for Genomic Research but can also be used

  3. Fire scar mapping for disaster response in KwaZulu-Natal South ...

    African Journals Online (AJOL)

    This study assessed the potential of the new Landsat 8 multispectral imagery in rapidly mapping fire scars to aid disaster management response teams in emergency efforts. Maximum likelihood and iso cluster algorithms where used to classify burnt and unburnt areas in KwaZulu-Natal, South Africa. The Landsat 8 sensor ...

  4. The MAP kinase substrate MKS1 is a regulator of plant defense responses

    DEFF Research Database (Denmark)

    Andreasson, E.; Jenkins, T.; Brodersen, P.

    2005-01-01

    Arabidopsis MAP kinase 4 (MPK4) functions as a regulator of pathogen defense responses, because it is required for both repression of salicylic acid (SA)-dependent resistance and for activation of jasmonate (JA)-dependent defense gene expression. To understand MPK4 signaling mechanisms, we used...

  5. Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1 into Diverse Memory T-Cell Populations.

    Directory of Open Access Journals (Sweden)

    Drew C Deniger

    Full Text Available T cells modified with chimeric antigen receptors (CARs targeting CD19 demonstrated clinical activity against some B-cell malignancies. However, this is often accompanied by a loss of normal CD19+ B cells and humoral immunity. Receptor tyrosine kinase-like orphan receptor-1 (ROR1 is expressed on sub-populations of B-cell malignancies and solid tumors, but not by healthy B cells or normal post-partum tissues. Thus, adoptive transfer of T cells specific for ROR1 has potential to eliminate tumor cells and spare healthy tissues. To test this hypothesis, we developed CARs targeting ROR1 in order to generate T cells specific for malignant cells. Two Sleeping Beauty transposons were constructed with 2nd generation ROR1-specific CARs signaling through CD3ζ and either CD28 (designated ROR1RCD28 or CD137 (designated ROR1RCD137 and were introduced into T cells. We selected for T cells expressing CAR through co-culture with γ-irradiated activating and propagating cells (AaPC, which co-expressed ROR1 and co-stimulatory molecules. Numeric expansion over one month of co-culture on AaPC in presence of soluble interleukin (IL-2 and IL-21 occurred and resulted in a diverse memory phenotype of CAR+ T cells as measured by non-enzymatic digital array (NanoString and multi-panel flow cytometry. Such T cells produced interferon-γ and had specific cytotoxic activity against ROR1+ tumors. Moreover, such cells could eliminate ROR1+ tumor xenografts, especially T cells expressing ROR1RCD137. Clinical trials will investigate the ability of ROR1-specific CAR+ T cells to specifically eliminate tumor cells while maintaining normal B-cell repertoire.

  6. Effect of age at Vaccination on Immunological Response to Recombinant MAP Subunit Vaccine

    DEFF Research Database (Denmark)

    Thakur, Aneesh; Aagaard, Claus; Jungersen, Gregers

    2011-01-01

    group responded well to the MAP multi-antigens and might need only one booster compared to the younger animals. Findings from this work could be interesting to determine the appropriate age of vaccination so as to generate the memory T cell pool and for MAP vaccine challenge experiments....... antigen specific IFN-c levels in response to heat shock protein and ESAT-6 family member protein antigens. It was observed that there was no effect of age on the IFN-c producing capacity of the animals in the different age groups after stimulation of whole blood with SEB. However, animals in the older age...

  7. The response analysis of fractional-order stochastic system via generalized cell mapping method.

    Science.gov (United States)

    Wang, Liang; Xue, Lili; Sun, Chunyan; Yue, Xiaole; Xu, Wei

    2018-01-01

    This paper is concerned with the response of a fractional-order stochastic system. The short memory principle is introduced to ensure that the response of the system is a Markov process. The generalized cell mapping method is applied to display the global dynamics of the noise-free system, such as attractors, basins of attraction, basin boundary, saddle, and invariant manifolds. The stochastic generalized cell mapping method is employed to obtain the evolutionary process of probability density functions of the response. The fractional-order ϕ 6 oscillator and the fractional-order smooth and discontinuous oscillator are taken as examples to give the implementations of our strategies. Studies have shown that the evolutionary direction of the probability density function of the fractional-order stochastic system is consistent with the unstable manifold. The effectiveness of the method is confirmed using Monte Carlo results.

  8. Mapping pathological phenotypes in a mouse model of CDKL5 disorder.

    Directory of Open Access Journals (Sweden)

    Elena Amendola

    Full Text Available Mutations in cyclin-dependent kinase-like 5 (CDKL5 cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 conditional knockout mouse model of CDKL5 disorder. Behavioral analysis of constitutive Cdkl5 knockout mice revealed key features of the human disorder, including limb clasping, hypoactivity, and abnormal eye tracking. Anatomical, physiological, and molecular analysis of the knockout uncovered potential pathological substrates of the disorder, including reduced dendritic arborization of cortical neurons, abnormal electroencephalograph (EEG responses to convulsant treatment, decreased visual evoked responses (VEPs, and alterations in the Akt/rpS6 signaling pathway. Selective knockout of Cdkl5 in excitatory and inhibitory forebrain neurons allowed us to map the behavioral features of the disorder to separable cell-types. These findings identify physiological and molecular deficits in specific forebrain neuron populations as possible pathological substrates in CDKL5 disorder.

  9. Mapping pathological phenotypes in a mouse model of CDKL5 disorder.

    Science.gov (United States)

    Amendola, Elena; Zhan, Yang; Mattucci, Camilla; Castroflorio, Enrico; Calcagno, Eleonora; Fuchs, Claudia; Lonetti, Giuseppina; Silingardi, Davide; Vyssotski, Alexei L; Farley, Dominika; Ciani, Elisabetta; Pizzorusso, Tommaso; Giustetto, Maurizio; Gross, Cornelius T

    2014-01-01

    Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 conditional knockout mouse model of CDKL5 disorder. Behavioral analysis of constitutive Cdkl5 knockout mice revealed key features of the human disorder, including limb clasping, hypoactivity, and abnormal eye tracking. Anatomical, physiological, and molecular analysis of the knockout uncovered potential pathological substrates of the disorder, including reduced dendritic arborization of cortical neurons, abnormal electroencephalograph (EEG) responses to convulsant treatment, decreased visual evoked responses (VEPs), and alterations in the Akt/rpS6 signaling pathway. Selective knockout of Cdkl5 in excitatory and inhibitory forebrain neurons allowed us to map the behavioral features of the disorder to separable cell-types. These findings identify physiological and molecular deficits in specific forebrain neuron populations as possible pathological substrates in CDKL5 disorder.

  10. The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA.

    Science.gov (United States)

    Li, Zhiru; Dugan, Aisling S; Bloomfield, Gareth; Skelton, Jason; Ivens, Alasdair; Losick, Vicki; Isberg, Ralph R

    2009-09-17

    The amoeba Dictyostelium discoideum can support replication of Legionella pneumophila. Here we identify the dupA gene, encoding a putative tyrosine kinase/dual-specificity phosphatase, in a screen for D. discoideum mutants altered in allowing L. pneumophila intracellular replication. Inactivation of dupA resulted in depressed L. pneumophila growth and sustained hyperphosphorylation of the amoebal MAP kinase ERK1, consistent with loss of a phosphatase activity. Bacterial challenge of wild-type amoebae induced dupA expression and resulted in transiently increased ERK1 phosphorylation, suggesting that dupA and ERK1 are part of a response to bacteria. Indeed, over 500 of the genes misregulated in the dupA(-) mutant were regulated in response to L. pneumophila infection, including some thought to have immune-like functions. MAP kinase phosphatases are known to be highly upregulated in macrophages challenged with L. pneumophila. Thus, DupA may regulate a MAP kinase response to bacteria that is conserved from amoebae to mammals.

  11. A multi-temporal analysis approach for land cover mapping in support of nuclear incident response

    Science.gov (United States)

    Sah, Shagan; van Aardt, Jan A. N.; McKeown, Donald M.; Messinger, David W.

    2012-06-01

    Remote sensing can be used to rapidly generate land use maps for assisting emergency response personnel with resource deployment decisions and impact assessments. In this study we focus on constructing accurate land cover maps to map the impacted area in the case of a nuclear material release. The proposed methodology involves integration of results from two different approaches to increase classification accuracy. The data used included RapidEye scenes over Nine Mile Point Nuclear Power Station (Oswego, NY). The first step was building a coarse-scale land cover map from freely available, high temporal resolution, MODIS data using a time-series approach. In the case of a nuclear accident, high spatial resolution commercial satellites such as RapidEye or IKONOS can acquire images of the affected area. Land use maps from the two image sources were integrated using a probability-based approach. Classification results were obtained for four land classes - forest, urban, water and vegetation - using Euclidean and Mahalanobis distances as metrics. Despite the coarse resolution of MODIS pixels, acceptable accuracies were obtained using time series features. The overall accuracies using the fusion based approach were in the neighborhood of 80%, when compared with GIS data sets from New York State. The classifications were augmented using this fused approach, with few supplementary advantages such as correction for cloud cover and independence from time of year. We concluded that this method would generate highly accurate land maps, using coarse spatial resolution time series satellite imagery and a single date, high spatial resolution, multi-spectral image.

  12. Role of hand dominance in mapping preferences for emotional-valence words to keypress responses.

    Science.gov (United States)

    Song, Xiaolei; Chen, Jing; Proctor, Robert W

    2017-10-01

    When a crossed-hands placement (right hand presses left key; left hand presses right key) is used in a two-choice spatial reaction task, the mapping of left stimulus to left key and right stimulus to right key yields faster responses than the opposite mapping. In contrast, de la Vega, Dudschig, De Filippis, Lachmair, and Kaup (2013) reported that when right-handed individuals classified words as having positive or negative affect, there was a benefit for mapping positive affect to the right hand (left key) and negative affect to the left hand (right key). The goal of the present study was to replicate and extend this seemingly distinct finding. Experiment 1 duplicated the design of that study without including nonword "no-go" trials but including a condition in which participants performed with an uncrossed hand placement. Results corroborated the benefit for mapping positive to the right hand and negative to the left hand with the hands crossed, and this benefit was as large as that obtained with the hands uncrossed. Experiment 2 confirmed the importance of the dominant/subordinate hand distinction with left-handed participants, and Experiment 3 showed, with right-handed participants, that it does not depend on which limb is placed over the other. The results verify that the mapping advantage for positive→right/negative→left is indeed due to the distinction between dominant and subordinate hands. Possible reasons for the difference between these results and those obtained with spatial-location stimuli are considered. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Exploring the representational basis of response-effect compatibility: Evidence from bilingual verbal response-effect mappings.

    Science.gov (United States)

    Földes, Noémi; Philipp, Andrea M; Badets, Arnaud; Koch, Iring

    2018-05-01

    The ideomotor principle states that actions are represented by their anticipated sensory effects. This notion is often tested using the response-effect compatibility (REC) paradigm, where participants' responses are followed either by a compatible or incompatible response effect (e.g., an effect on the right side after a right-hand response is considered R-E compatible due to the spatial overlap, whereas an effect on the left side after the right-hand response is considered incompatible). Shorter reaction times are typically observed in the compatible condition compared to the incompatible condition (i.e., REC effect), suggesting that effect anticipation plays a role in action control. Previous evidence from verbal REC suggested that effect anticipation can be due to conceptual R-E overlap, but there was also phonological overlap (i.e., anticipated reading of a word preceded by the vocal response of saying that very word). To examine the representational basis of REC, in three experiments, we introduced a bilingual R-E mapping to exclude phonological R-E overlap (i.e., in the R-E compatible condition, the translation equivalent of the response word is presented as an effect word in a different language). Our findings show that the REC effect is obtained when presenting the effect word in the same language as the response (i.e., monolingual condition), but the compatibility effect was not found when the semantically same word is presented in a different language, suggesting no conceptually generalized REC in a bilingual setting. (232 words). Copyright © 2018 Elsevier B.V. All rights reserved.

  14. Stochastic response and bifurcation of periodically driven nonlinear oscillators by the generalized cell mapping method

    Science.gov (United States)

    Han, Qun; Xu, Wei; Sun, Jian-Qiao

    2016-09-01

    The stochastic response of nonlinear oscillators under periodic and Gaussian white noise excitations is studied with the generalized cell mapping based on short-time Gaussian approximation (GCM/STGA) method. The solutions of the transition probability density functions over a small fraction of the period are constructed by the STGA scheme in order to construct the GCM over one complete period. Both the transient and steady-state probability density functions (PDFs) of a smooth and discontinuous (SD) oscillator are computed to illustrate the application of the method. The accuracy of the results is verified by direct Monte Carlo simulations. The transient responses show the evolution of the PDFs from being Gaussian to non-Gaussian. The effect of a chaotic saddle on the stochastic response is also studied. The stochastic P-bifurcation in terms of the steady-state PDFs occurs with the decrease of the smoothness parameter, which corresponds to the deterministic pitchfork bifurcation.

  15. Using Remote Sensing Mapping and Growth Response to Environmental Variability to Aide Aquatic Invasive Plant Management

    Science.gov (United States)

    Bubenheim, David L.; Schlick, Greg; Genovese, Vanessa; Wilson, Kenneth D.

    2018-01-01

    Management of aquatic weeds in complex watersheds and river systems present many challenges to assessment, planning and implementation of management practices for floating and submerged aquatic invasive plants. The Delta Region Areawide Aquatic Weed Project (DRAAWP), a USDA sponsored area-wide project, is working to enhance planning, decision-making and operational efficiency in the California Sacramento-San Joaquin Delta. Satellite and airborne remote sensing are used map (area coverage and biomass density), direct operations, and assess management impacts on plant communities. Archived satellite records enable review of results following previous climate and management events and aide in developing long-term strategies. Examples of remote sensing aiding effectiveness of aquatic weed management will be discussed as well as areas for potential technological improvement. Modeling at local and watershed scales using the SWAT modeling tool provides insight into land-use effects on water quality (described by Zhang in same Symposium). Controlled environment growth studies have been conducted to quantify the growth response of invasive aquatic plants to water quality and other environmental factors. Environmental variability occurs across a range of time scales from long-term climate and seasonal trends to short-term water flow mediated variations. Response time for invasive species response are examined at time scales of weeks, day, and hours using a combination of study duration and growth assessment techniques to assess water quality, temperature (air and water), nitrogen, phosphorus, and light effects. These provide response parameters for plant growth models in response to the variation and interact with management and economic models associated with aquatic weed management. Plant growth models are to be informed by remote sensing and applied spatially across the Delta to balance location and type of aquatic plant, growth response to altered environments and

  16. Lower Colorado River Geographic Response Plan Restricted Web Mapping Service, Region 9, 2012, US EPA Region 9

    Data.gov (United States)

    U.S. Environmental Protection Agency — This map service is comprised of data related to Geographic Response Plans (GRPs) for the Lower Colorado River. Data layers were contributed by various stakeholders...

  17. Temperature response of the neuronal cytoskeleton mapped via atomic force and fluorescence microscopy

    International Nuclear Information System (INIS)

    Spedden, Elise; Staii, Cristian; Kaplan, David L

    2013-01-01

    Neuronal cells change their growth properties in response to external physical stimuli such as variations in external temperature, stiffness of the growth substrate, or topographical guidance cues. Detailed knowledge of the mechanisms that control these biomechanical responses is necessary for understanding the basic principles that underlie neuronal growth and regeneration. Here, we present elasticity maps of living cortical neurons (embryonic rat) as a function of temperature, and correlate these maps to the locations of internal structural components of the cytoskeleton. Neurons display a significant increase in the average elastic modulus upon a decrease in ambient temperature from 37 to 25 °C. We demonstrate that the dominant mechanism by which the elasticity of the neurons changes in response to temperature is the stiffening of the actin components of the cytoskeleton induced by myosin II. We also report a reversible shift in the location and composition of the high-stiffness areas of the neuron cytoskeleton with temperature. At 37 °C the areas of the cell displaying high elastic modulus overlap with the tubulin-dense regions, while at 25 °C these high-stiffness areas correspond to the actin-dense regions of the cytoskeleton. These results demonstrate the importance of considering temperature effects when investigating cytoskeletal dynamics in cells. (paper)

  18. Mapping genetic variants associated with beta-adrenergic responses in inbred mice.

    Directory of Open Access Journals (Sweden)

    Micha Hersch

    Full Text Available β-blockers and β-agonists are primarily used to treat cardiovascular diseases. Inter-individual variability in response to both drug classes is well recognized, yet the identity and relative contribution of the genetic players involved are poorly understood. This work is the first genome-wide association study (GWAS addressing the values and susceptibility of cardiovascular-related traits to a selective β(1-blocker, Atenolol (ate, and a β-agonist, Isoproterenol (iso. The phenotypic dataset consisted of 27 highly heritable traits, each measured across 22 inbred mouse strains and four pharmacological conditions. The genotypic panel comprised 79922 informative SNPs of the mouse HapMap resource. Associations were mapped by Efficient Mixed Model Association (EMMA, a method that corrects for the population structure and genetic relatedness of the various strains. A total of 205 separate genome-wide scans were analyzed. The most significant hits include three candidate loci related to cardiac and body weight, three loci for electrocardiographic (ECG values, two loci for the susceptibility of atrial weight index to iso, four loci for the susceptibility of systolic blood pressure (SBP to perturbations of the β-adrenergic system, and one locus for the responsiveness of QTc (p<10(-8. An additional 60 loci were suggestive for one or the other of the 27 traits, while 46 others were suggestive for one or the other drug effects (p<10(-6. Most hits tagged unexpected regions, yet at least two loci for the susceptibility of SBP to β-adrenergic drugs pointed at members of the hypothalamic-pituitary-thyroid axis. Loci for cardiac-related traits were preferentially enriched in genes expressed in the heart, while 23% of the testable loci were replicated with datasets of the Mouse Phenome Database (MPD. Altogether these data and validation tests indicate that the mapped loci are relevant to the traits and responses studied.

  19. Dose-response functions and corrosion mapping for a small geographical area

    International Nuclear Information System (INIS)

    Haagenrud, S.E.; Henriksen, J.F.; Gram, F.

    1985-01-01

    Detailed corrosion and environmental measurements have been used to develop dose response (D/R) functions for carbon steel, zinc, copper, and aluminum for a 26 x 31 km urban/rural area with approximately homogeneous climate. The D/R functions, expressed in terms of SO 2 and time of wetness, were of the same type for all four metals. The SO 2 contribution to the total corrosion dominates in the centers of towns and around an industrial plant. Corrosion maps for the whole area were established

  20. Genome-Wide Association Mapping of Leaf Rust Response in a Durum Wheat Worldwide Germplasm Collection.

    Science.gov (United States)

    Aoun, Meriem; Breiland, Matthew; Kathryn Turner, M; Loladze, Alexander; Chao, Shiaoman; Xu, Steven S; Ammar, Karim; Anderson, James A; Kolmer, James A; Acevedo, Maricelis

    2016-11-01

    Leaf rust (caused by Erikss. []) is increasingly impacting durum wheat ( L. var. ) production with the recent appearance of races with virulence to widely grown cultivars in many durum producing areas worldwide. A highly virulent race on durum wheat was recently detected in Kansas. This race may spread to the northern Great Plains, where most of the US durum wheat is produced. The objective of this study was to identify sources of resistance to several races from the United States and Mexico at seedling stage in the greenhouse and at adult stage in field experiments. Genome-wide association study (GWAS) was used to identify single-nucleotide polymorphism (SNP) markers associated with leaf rust response in a worldwide durum wheat collection of 496 accessions. Thirteen accessions were resistant across all experiments. Association mapping revealed 88 significant SNPs associated with leaf rust response. Of these, 33 SNPs were located on chromosomes 2A and 2B, and 55 SNPs were distributed across all other chromosomes except for 1B and 7B. Twenty markers were associated with leaf rust response at seedling stage, while 68 markers were associated with leaf rust response at adult plant stage. The current study identified a total of 14 previously uncharacterized loci associated with leaf rust response in durum wheat. The discovery of these loci through association mapping (AM) is a significant step in identifying useful sources of resistance that can be used to broaden the relatively narrow leaf rust resistance spectrum in durum wheat germplasm. Copyright © 2016 Crop Science Society of America.

  1. Magnetoresistance sensitivity mapping of the localized response of contiguous and lead-overlaid sensors

    International Nuclear Information System (INIS)

    Sankar, Sandra

    2003-01-01

    Magnetoresistance sensitivity mapping (MSM) was used to investigate the local response of magnetic recording sensors without convolution of the writer, magnetic media and data channel. From a 2D map of the local sensor response, the intrinsic pulse shape and magnetic track profile are readily obtained. Pulse-width is a concern for high data rate since if pulse-width is too broad, individual transitions become difficult to distinguish. Track profiles are important because due to the small difference between magnetic write-width and magnetic read-width, side reading will lead to an increase in noise. Three experiments are discussed: the dependence of the pulse-width (PW50) of the standard contiguous junction (CJ) design on shield-to-shield spacing; a comparison of the pulse shape of lead-overlaid (LOL) and CJ designs; and a comparison of the magnetic track profile (including track-width and skirt ratio) of LOL and CJ designs. The LOL design offers an increased sensitivity; however, as seen from MSM, the penalties are broadening of the track and pulse profiles. These are a direct result of the finite current in the lead overlay region and an increased shield-to-shield spacing in that region. The MSM image shows a curvature, which is associated with the topography of the top shield due to the lead overlay

  2. UAV Deployment Exercise for Mapping Purposes: Evaluation of Emergency Response Applications.

    Science.gov (United States)

    Boccardo, Piero; Chiabrando, Filiberto; Dutto, Furio; Tonolo, Fabio Giulio; Lingua, Andrea

    2015-07-02

    Exploiting the decrease of costs related to UAV technology, the humanitarian community started piloting the use of similar systems in humanitarian crises several years ago in different application fields, i.e., disaster mapping and information gathering, community capacity building, logistics and even transportation of goods. Part of the author's group, composed of researchers in the field of applied geomatics, has been piloting the use of UAVs since 2006, with a specific focus on disaster management application. In the framework of such activities, a UAV deployment exercise was jointly organized with the Regional Civil Protection authority, mainly aimed at assessing the operational procedures to deploy UAVs for mapping purposes and the usability of the acquired data in an emergency response context. In the paper the technical features of the UAV platforms will be described, comparing the main advantages/disadvantages of fixed-wing versus rotor platforms. The main phases of the adopted operational procedure will be discussed and assessed especially in terms of time required to carry out each step, highlighting potential bottlenecks and in view of the national regulation framework, which is rapidly evolving. Different methodologies for the processing of the acquired data will be described and discussed, evaluating the fitness for emergency response applications.

  3. UAV Deployment Exercise for Mapping Purposes: Evaluation of Emergency Response Applications

    Directory of Open Access Journals (Sweden)

    Piero Boccardo

    2015-07-01

    Full Text Available Exploiting the decrease of costs related to UAV technology, the humanitarian community started piloting the use of similar systems in humanitarian crises several years ago in different application fields, i.e., disaster mapping and information gathering, community capacity building, logistics and even transportation of goods. Part of the author’s group, composed of researchers in the field of applied geomatics, has been piloting the use of UAVs since 2006, with a specific focus on disaster management application. In the framework of such activities, a UAV deployment exercise was jointly organized with the Regional Civil Protection authority, mainly aimed at assessing the operational procedures to deploy UAVs for mapping purposes and the usability of the acquired data in an emergency response context. In the paper the technical features of the UAV platforms will be described, comparing the main advantages/disadvantages of fixed-wing versus rotor platforms. The main phases of the adopted operational procedure will be discussed and assessed especially in terms of time required to carry out each step, highlighting potential bottlenecks and in view of the national regulation framework, which is rapidly evolving. Different methodologies for the processing of the acquired data will be described and discussed, evaluating the fitness for emergency response applications.

  4. Mapping the sequence of brain events in response to disgusting food.

    Science.gov (United States)

    Pujol, Jesus; Blanco-Hinojo, Laura; Coronas, Ramón; Esteba-Castillo, Susanna; Rigla, Mercedes; Martínez-Vilavella, Gerard; Deus, Joan; Novell, Ramón; Caixàs, Assumpta

    2018-01-01

    Warning signals indicating that a food is potentially dangerous may evoke a response that is not limited to the feeling of disgust. We investigated the sequence of brain events in response to visual representations of disgusting food using a dynamic image analysis. Functional MRI was acquired in 30 healthy subjects while they were watching a movie showing disgusting food scenes interspersed with the scenes of appetizing food. Imaging analysis included the identification of the global brain response and the generation of frame-by-frame activation maps at the temporal resolution of 2 s. Robust activations were identified in brain structures conventionally associated with the experience of disgust, but our analysis also captured a variety of other brain elements showing distinct temporal evolutions. The earliest events included transient changes in the orbitofrontal cortex and visual areas, followed by a more durable engagement of the periaqueductal gray, a pivotal element in the mediation of responses to threat. A subsequent core phase was characterized by the activation of subcortical and cortical structures directly concerned not only with the emotional dimension of disgust (e.g., amygdala-hippocampus, insula), but also with the regulation of food intake (e.g., hypothalamus). In a later phase, neural excitement extended to broad cortical areas, the thalamus and cerebellum, and finally to the default mode network that signaled the progressive termination of the evoked response. The response to disgusting food representations is not limited to the emotional domain of disgust, and may sequentially involve a variety of broadly distributed brain networks. Hum Brain Mapp 39:369-380, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  5. Mapping the T helper cell response to acid α-glucosidase in Pompe mice.

    Science.gov (United States)

    Nayak, Sushrusha; Sivakumar, Ramya; Cao, Ou; Daniell, Henry; Byrne, Barry J; Herzog, Roland W

    2012-06-01

    Pompe disease is a neuromuscular disease caused by an inherited deficiency of the lysosomal enzyme acid α-glucosidase (GAA). The resulting accumulation of glycogen causes muscle weakness with the severe form of the disease resulting in death by cardiorespiratory failure in the first year of life. The only available treatment, enzyme replacement therapy (ERT) with recombinant GAA (rhGAA), is severely hampered by antibody responses that reduce efficacy and cause immunotoxicities. Currently, Pompe mice represent the only pre-clinical model for development of new treatments and for immunological studies. While antibody formation following ERT in this model has been described, the underlying T cell response has not been studied. In order to define the T helper response to rhGAA in Pompe mice, immunodominant CD4(+) T cell epitopes were mapped in GAA(-/-) 129SVE mice using ELISpot. Additionally, cytokine responses and antibody formation against rhGAA during ERT were measured. Among the three CD4(+) T cell epitopes identified, only epitope IFLGPEPKSVVQ, predicted to be the strongest MHC II binder, consistently contributed to IL-4 production. Frequencies of IL-4 producing T cells were considerably higher than those of IL-17 or IFN-γ producing cells, suggesting a predominantly Th2 cell mediated response. This is further supported by IgG1 being the prevalent antibody subclass against rhGAA during ERT and consistent with prior reports on IgE formation and anaphylaxis in this model. These results will facilitate mechanistic studies of the immune response to rhGAA in Pompe mice during development of new therapies and tolerance protocols. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. Optimization of microwave-assisted extraction (MAP) for ginseng components by response surface methodology.

    Science.gov (United States)

    Kwon, Joong-Ho; Bélanger, Jacqueline M R; Paré, J R Jocelyn

    2003-03-26

    Response surface methodology (RSM) was applied to predict optimum conditions for microwave-assisted extraction-a MAP technology-of saponin components from ginseng roots. A central composite design was used to monitor the effect of ethanol concentration (30-90%, X(1)) and extraction time (30-270 s, X(2)) on dependent variables, such as total extract yield (Y(1)), crude saponin content (Y(2)), and saponin ratio (Y(3)), under atmospheric pressure conditions when focused microwaves were applied at an emission frequency of 2450 MHz. In MAP under pre-established conditions, correlation coefficients (R (2)) of the models for total extract yield and crude saponin were 0.9841 (p extraction conditions were predicted for each variable as 52.6% ethanol and 224.7 s in extract yield and as 77.3% ethanol and 295.1 s in crude saponins, respectively. Estimated maximum values at predicted optimum conditions were in good agreement with experimental values.

  7. SiSeRHMap v1.0: a simulator for mapped seismic response using a hybrid model

    Science.gov (United States)

    Grelle, Gerardo; Bonito, Laura; Lampasi, Alessandro; Revellino, Paola; Guerriero, Luigi; Sappa, Giuseppe; Guadagno, Francesco Maria

    2016-04-01

    The SiSeRHMap (simulator for mapped seismic response using a hybrid model) is a computerized methodology capable of elaborating prediction maps of seismic response in terms of acceleration spectra. It was realized on the basis of a hybrid model which combines different approaches and models in a new and non-conventional way. These approaches and models are organized in a code architecture composed of five interdependent modules. A GIS (geographic information system) cubic model (GCM), which is a layered computational structure based on the concept of lithodynamic units and zones, aims at reproducing a parameterized layered subsoil model. A meta-modelling process confers a hybrid nature to the methodology. In this process, the one-dimensional (1-D) linear equivalent analysis produces acceleration response spectra for a specified number of site profiles using one or more input motions. The shear wave velocity-thickness profiles, defined as trainers, are randomly selected in each zone. Subsequently, a numerical adaptive simulation model (Emul-spectra) is optimized on the above trainer acceleration response spectra by means of a dedicated evolutionary algorithm (EA) and the Levenberg-Marquardt algorithm (LMA) as the final optimizer. In the final step, the GCM maps executor module produces a serial map set of a stratigraphic seismic response at different periods, grid solving the calibrated Emul-spectra model. In addition, the spectra topographic amplification is also computed by means of a 3-D validated numerical prediction model. This model is built to match the results of the numerical simulations related to isolate reliefs using GIS morphometric data. In this way, different sets of seismic response maps are developed on which maps of design acceleration response spectra are also defined by means of an enveloping technique.

  8. Collaborative damage mapping for emergency response: the role of Cognitive Systems Engineering

    Science.gov (United States)

    Kerle, N.; Hoffman, R. R.

    2013-01-01

    Remote sensing is increasingly used to assess disaster damage, traditionally by professional image analysts. A recent alternative is crowdsourcing by volunteers experienced in remote sensing, using internet-based mapping portals. We identify a range of problems in current approaches, including how volunteers can best be instructed for the task, ensuring that instructions are accurately understood and translate into valid results, or how the mapping scheme must be adapted for different map user needs. The volunteers, the mapping organizers, and the map users all perform complex cognitive tasks, yet little is known about the actual information needs of the users. We also identify problematic assumptions about the capabilities of the volunteers, principally related to the ability to perform the mapping, and to understand mapping instructions unambiguously. We propose that any robust scheme for collaborative damage mapping must rely on Cognitive Systems Engineering and its principal method, Cognitive Task Analysis (CTA), to understand the information and decision requirements of the map and image users, and how the volunteers can be optimally instructed and their mapping contributions merged into suitable map products. We recommend an iterative approach involving map users, remote sensing specialists, cognitive systems engineers and instructional designers, as well as experimental psychologists.

  9. Effects of registration error on parametric response map analysis: a simulation study using liver CT-perfusion images

    International Nuclear Information System (INIS)

    Lausch, A; Lee, T Y; Wong, E; Jensen, N K G; Chen, J; Lock, M

    2014-01-01

    Purpose: To investigate the effects of registration error (RE) on parametric response map (PRM) analysis of pre and post-radiotherapy (RT) functional images. Methods: Arterial blood flow maps (ABF) were generated from the CT-perfusion scans of 5 patients with hepatocellular carcinoma. ABF values within each patient map were modified to produce seven new ABF maps simulating 7 distinct post-RT functional change scenarios. Ground truth PRMs were generated for each patient by comparing the simulated and original ABF maps. Each simulated ABF map was then deformed by different magnitudes of realistic respiratory motion in order to simulate RE. PRMs were generated for each of the deformed maps and then compared to the ground truth PRMs to produce estimates of RE-induced misclassification. Main findings: The percentage of voxels misclassified as decreasing, no change, and increasing, increased with RE For all patients, increasing RE was observed to increase the number of high post-RT ABF voxels associated with low pre-RT ABF voxels and vice versa. 3 mm of average tumour RE resulted in 18-45% tumour voxel misclassification rates. Conclusions: RE induced misclassification posed challenges for PRM analysis in the liver where registration accuracy tends to be lower. Quantitative understanding of the sensitivity of the PRM method to registration error is required if PRMs are to be used to guide radiation therapy dose painting techniques.

  10. How to include the variability of TMS responses in simulations: a speech mapping case study

    Science.gov (United States)

    De Geeter, N.; Lioumis, P.; Laakso, A.; Crevecoeur, G.; Dupré, L.

    2016-11-01

    When delivered over a specific cortical site, TMS can temporarily disrupt the ongoing process in that area. This allows mapping of speech-related areas for preoperative evaluation purposes. We numerically explore the observed variability of TMS responses during a speech mapping experiment performed with a neuronavigation system. We selected four cases with very small perturbations in coil position and orientation. In one case (E) a naming error occurred, while in the other cases (NEA, B, C) the subject appointed the images as smoothly as without TMS. A realistic anisotropic head model was constructed of the subject from T1-weighted and diffusion-weighted MRI. The induced electric field distributions were computed, associated to the coil parameters retrieved from the neuronavigation system. Finally, the membrane potentials along relevant white matter fibre tracts, extracted from DTI-based tractography, were computed using a compartmental cable equation. While only minor differences could be noticed between the induced electric field distributions of the four cases, computing the corresponding membrane potentials revealed different subsets of tracts were activated. A single tract was activated for all coil positions. Another tract was only triggered for case E. NEA induced action potentials in 13 tracts, while NEB stimulated 11 tracts and NEC one. The calculated results are certainly sensitive to the coil specifications, demonstrating the observed variability in this study. However, even though a tract connecting Broca’s with Wernicke’s area is only triggered for the error case, further research is needed on other study cases and on refining the neural model with synapses and network connections. Case- and subject-specific modelling that includes both electromagnetic fields and neuronal activity enables demonstration of the variability in TMS experiments and can capture the interaction with complex neural networks.

  11. Spatial representation and cognitive modulation of response variability in the lateral intraparietal area priority map.

    Science.gov (United States)

    Falkner, Annegret L; Goldberg, Michael E; Krishna, B Suresh

    2013-10-09

    The lateral intraparietal area (LIP) in the macaque contains a priority-based representation of the visual scene. We previously showed that the mean spike rate of LIP neurons is strongly influenced by spatially wide-ranging surround suppression in a manner that effectively sharpens the priority map. Reducing response variability can also improve the precision of LIP's priority map. We show that when a monkey plans a visually guided delayed saccade with an intervening distractor, variability (measured by the Fano factor) decreases both for neurons representing the saccade goal and for neurons representing the broad spatial surround. The reduction in Fano factor is maximal for neurons representing the saccade goal and steadily decreases for neurons representing more distant locations. LIP Fano factor changes are behaviorally significant: increasing expected reward leads to lower variability for the LIP representation of both the target and distractor locations, and trials with shorter latency saccades are associated with lower Fano factors in neurons representing the surround. Thus, the LIP Fano factor reflects both stimulus and behavioral engagement. Quantitative modeling shows that the interaction between mean spike count and target-receptive field (RF) distance in the surround during the predistractor epoch is multiplicative: the Fano factor increases more steeply with mean spike count further away from the RF. A negative-binomial model for LIP spike counts captures these findings quantitatively, suggests underlying mechanisms based on trial-by-trial variations in mean spike rate or burst-firing patterns, and potentially provides a principled framework to account simultaneously for the previously observed unsystematic relationships between spike rate and variability in different brain areas.

  12. Supervisor tolerance-responsiveness to substance abuse and workplace prevention training: use of a cognitive mapping tool.

    Science.gov (United States)

    Bennett, Joel B; Lehman, Wayne E K

    2002-02-01

    Supervisor tolerance-responsiveness, referring to the attitudes and behaviors associated with either ignoring or taking proactive steps with troubled employees, was investigated in two studies. The studies were conducted to help examine, understand and improve supervisor responsiveness to employee substance abuse. Study 1 examined supervisor response to and tolerance of coworker substance use and ways of interfacing with the Employee Assistance Program (EAP) in two workplaces (n = 244 and 107). These surveys suggested that engaging supervisors in a dialogue about tolerance might improve their willingness to use the EAP. Study 2 was a randomized control field experiment that assessed a team-oriented training. This training adopted a cognitive mapping technique to help improve supervisor responsiveness. Supervisors receiving this training (n = 29) were more likely to improve on several dimensions of responsiveness (e.g. likely to contact the EAP) than were supervisors who received a more didactic, informational training (n = 23) or a no-training control group (n = 17). Trained supervisors also showed increases in their own help-seeking behavior. Procedures and maps from the mapping activity (two-stage conversational mapping) are described. Overall, results indicate that while supervisor tolerance of coworker substance use inhibits EAP utilization, it may be possible to address this tolerance using team-oriented prevention training in the work-site.

  13. A morphological and immunophenotypic map of the immune response in Merkel cell carcinoma.

    Science.gov (United States)

    Walsh, Noreen M; Fleming, Kirsten E; Hanly, John G; Dakin Hache, Kelly; Doucette, Steve; Ferrara, Gerardo; Cerroni, Lorenzo

    2016-06-01

    The susceptibility of Merkel cell carcinoma to the host immune response has prompted a search for effective immunotherapy. CD8-positive T lymphocytes are considered key effectors of this response, but the cellular infiltrates also harbor tumor-protective agents. By developing a comprehensive morphological and immunophenotypic map of tumor-infiltrating lymphocytes (TILS) in Merkel cell carcinoma, we aimed to establish a useful template for future studies. Twenty-two cases (mean age, 79years [range, 52-95]; male-female ratio, 10:12) were studied. TILS were categorized as brisk (7), nonbrisk (9), and absent(6). Merkel cell polyomavirus (MCPyV)-positive (16) and -negative (6) cases were included, as were those with pure (18) and combined (4) morphologies. One MCPyV+ case had undergone spontaneous regression. Immunohistochemical markers included CD3, CD4, CD8, CD20, CD68, FoxP3, PD-1, and CD123. Statistical analysis used Fisher exact tests and Spearman correlations. There was a significant correlation between brisk TILs and MCPyV+ status (P=.025). CD8+ T lymphocytes predominated, were present in significantly higher proportions in brisk infiltrates (P=.003), and showed a significant predilection for the intratumoral environment (P=.003). Immune inhibitors including T regulatory cells (FOXP3+) and PD-1+ "exhausted" immunocytes were present in lower proportions. Our findings support (1) the link between a brisk immune response and MCPyV positivity, (2) the supremacy of CD8+ cells in effecting immunity, and (3) the incorporation of immune inhibitors within the global infiltrate. Efforts to therapeutically arm the "effectors" and disarm the "detractors" are well focused. These will likely have the greatest impact on MCPyV-positive cases. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Mapping and characterization of positive and negative BOLD responses to visual stimulation in multiple brain regions at 7T

    NARCIS (Netherlands)

    Jorge, João; Figueiredo, Patrícia; Gruetter, Rolf; Van der Zwaag, W.

    External stimuli and tasks often elicit negative BOLD responses in various brain regions, and growing experimental evidence supports that these phenomena are functionally meaningful. In this work, the high sensitivity available at 7T was explored to map and characterize both positive (PBRs) and

  15. Two-to-one colour-response mapping and the presence of semantic conflict in the Stroop task

    Directory of Open Access Journals (Sweden)

    Nabil eHasshim

    2014-10-01

    Full Text Available A series of recent studies have utilised the two-to-one mapping paradigm in the Stroop task. In this paradigm, the word red might be presented in blue when both red and blue share the same response key (same-response trials. This manipulation has been used to show the separate contributions of (within semantic category conflict and response conflict to Stroop interference. Such results evidencing semantic category conflict are incompatible with models of the Stroop task that are based on response conflict only. However, the nature of the same-response trials is unclear since they are also likely to involve response facilitation given that both dimensions of the stimulus provide evidence towards the same response key. In this study we explored this possibility by comparing them with three other trial types. We report strong (Bayesian evidence for no statistical difference between same-response and non-colour word neutral trials, faster responses to same-response trials than to non-response set incongruent trials, and no differences between same-response vs. congruent trials when contingency is controlled. Our results suggest that when RT is the dependent variable, same-response trials are not different from neutral trials indicating that they cannot be used reliably to determine the presence or absence of semantic category conflict. In light of these results, the interpretation of a series of recent studies might have to be reassessed.

  16. Principal component analysis of the CT density histogram to generate parametric response maps of COPD

    Science.gov (United States)

    Zha, N.; Capaldi, D. P. I.; Pike, D.; McCormack, D. G.; Cunningham, I. A.; Parraga, G.

    2015-03-01

    Pulmonary x-ray computed tomography (CT) may be used to characterize emphysema and airways disease in patients with chronic obstructive pulmonary disease (COPD). One analysis approach - parametric response mapping (PMR) utilizes registered inspiratory and expiratory CT image volumes and CT-density-histogram thresholds, but there is no consensus regarding the threshold values used, or their clinical meaning. Principal-component-analysis (PCA) of the CT density histogram can be exploited to quantify emphysema using data-driven CT-density-histogram thresholds. Thus, the objective of this proof-of-concept demonstration was to develop a PRM approach using PCA-derived thresholds in COPD patients and ex-smokers without airflow limitation. Methods: Fifteen COPD ex-smokers and 5 normal ex-smokers were evaluated. Thoracic CT images were also acquired at full inspiration and full expiration and these images were non-rigidly co-registered. PCA was performed for the CT density histograms, from which the components with the highest eigenvalues greater than one were summed. Since the values of the principal component curve correlate directly with the variability in the sample, the maximum and minimum points on the curve were used as threshold values for the PCA-adjusted PRM technique. Results: A significant correlation was determined between conventional and PCA-adjusted PRM with 3He MRI apparent diffusion coefficient (p<0.001), with CT RA950 (p<0.0001), as well as with 3He MRI ventilation defect percent, a measurement of both small airways disease (p=0.049 and p=0.06, respectively) and emphysema (p=0.02). Conclusions: PRM generated using PCA thresholds of the CT density histogram showed significant correlations with CT and 3He MRI measurements of emphysema, but not airways disease.

  17. Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker.

    Science.gov (United States)

    Horn, Felix C; Marshall, Helen; Collier, Guilhem J; Kay, Richard; Siddiqui, Salman; Brightling, Christopher E; Parra-Robles, Juan; Wild, Jim M

    2017-09-01

    Purpose To assess the magnitude of regional response to respiratory therapeutic agents in the lungs by using treatment response mapping (TRM) with hyperpolarized gas magnetic resonance (MR) imaging. TRM was used to quantify regional physiologic response in adults with asthma who underwent a bronchodilator challenge. Materials and Methods This study was approved by the national research ethics committee and was performed with informed consent. Imaging was performed in 20 adult patients with asthma by using hyperpolarized helium 3 ( 3 He) ventilation MR imaging. Two sets of baseline images were acquired before inhalation of a bronchodilating agent (salbutamol 400 μg), and one set was acquired after. All images were registered for voxelwise comparison. Regional treatment response, ΔR(r), was calculated as the difference in regional gas distribution (R[r] = ratio of inhaled gas to total volume of a voxel when normalized for lung inflation volume) before and after intervention. A voxelwise activation threshold from the variability of the baseline images was applied to ΔR(r) maps. The summed global treatment response map (ΔR net ) was then used as a global lung index for comparison with metrics of bronchodilator response measured by using spirometry and the global imaging metric percentage ventilated volume (%VV). Results ΔR net showed significant correlation (P treatment effect was detected with all metrics; however, ΔR net showed a lower intersubject coefficient of variation (64%) than all of the other tests (coefficient of variation, ≥99%). Conclusion TRM provides regional quantitative information on changes in inhaled gas ventilation in response to therapy. This method could be used as a sensitive regional outcome metric for novel respiratory interventions. © RSNA, 2017 Online supplemental material is available for this article.

  18. Near-Surface Geophysical Mapping of the Hydrological Response to an Intense Rainfall Event at the Field Scale

    Science.gov (United States)

    Martínez, G.; Vanderlinden, K.; Giraldez, J. V.; Espejo, A. J.; Muriel, J. L.

    2009-12-01

    Soil moisture plays an important role in a wide variety of biogeochemical fluxes in the soil-plant-atmosphere system and governs the (eco)hydrological response of a catchment to an external forcing such as rainfall. Near-surface electromagnetic induction (EMI) sensors that measure the soil apparent electrical conductivity (ECa) provide a fast and non-invasive means for characterizing this response at the field or catchment scale through high-resolution time-lapse mapping. Here we show how ECa maps, obtained before and after an intense rainfall event of 125 mm h-1, elucidate differences in soil moisture patterns and hydrologic response of an experimental field as a consequence of differed soil management. The dryland field (Vertisol) was located in SW Spain and cropped with a typical wheat-sunflower-legume rotation. Both, near-surface and subsurface ECa (ECas and ECad, respectively), were measured using the EM38-DD EMI sensor in a mobile configuration. Raw ECa measurements and Mean Relative Differences (MRD) provided information on soil moisture patterns while time-lapse maps were used to evaluate the hydrologic response of the field. ECa maps of the field, measured before and after the rainfall event showed similar patterns. The field depressions where most of water and sediments accumulated had the highest ECa and MRD values. The SE-oriented soil, which was deeper and more exposed to sun and wind, showed the lowest ECa and MRD. The largest differences raised in the central part of the field where a high ECa and MRD area appeared after the rainfall event as a consequence of the smaller soil depth and a possible subsurface flux concentration. Time-lapse maps of both ECa and MRD were also similar. The direct drill plots showed higher increments of ECa and MRD as a result of the smaller runoff production. Time-lapse ECa increments showed a bimodal distribution differentiating clearly the direct drill from the conventional and minimum tillage plots. However this kind

  19. Identification of genes involved in a water stress response in timothy and mapping of orthologous loci in perennial ryegrass

    DEFF Research Database (Denmark)

    Jonavičienė, Kristina; Studer, Bruno; Asp, Torben

    2012-01-01

    In order to characterize the response of selected grasses to water stress, relative water content (RWC) in leaves and quantum efficiency of photosystem 2 (Fv/Fm) were measured in Phleum pratense L., P. bertolonii DC. and P. phleoides H. Karst. during 6 d of water stress. The results indicated...... differential responses to water stress among the three Phleum species with higher water deficit sensitivity of P. pratense and P. bertolonii than that of P. phleoides. The cDNA-amplified fragment length polymorphism (cDNA-AFLP) technique was applied to identify differentially expressed genes responding...... to water stress in P. pratense. Cloned and sequenced differentially expressed fragments (DEFs) were used for primer design in order to identify orthologous genes in Lolium perenne L. Twelve genes orthologous to P. pratense DEFs were mapped in the L. perenne mapping population VrnA based on a high...

  20. Auditory middle latency responses differ in right- and left-handed subjects: an evaluation through topographic brain mapping.

    Science.gov (United States)

    Mohebbi, Mehrnaz; Mahmoudian, Saeid; Alborzi, Marzieh Sharifian; Najafi-Koopaie, Mojtaba; Farahani, Ehsan Darestani; Farhadi, Mohammad

    2014-09-01

    To investigate the association of handedness with auditory middle latency responses (AMLRs) using topographic brain mapping by comparing amplitudes and latencies in frontocentral and hemispheric regions of interest (ROIs). The study included 44 healthy subjects with normal hearing (22 left handed and 22 right handed). AMLRs were recorded from 29 scalp electrodes in response to binaural 4-kHz tone bursts. Frontocentral ROI comparisons revealed that Pa and Pb amplitudes were significantly larger in the left-handed than the right-handed group. Topographic brain maps showed different distributions in AMLR components between the two groups. In hemispheric comparisons, Pa amplitude differed significantly across groups. A left-hemisphere emphasis of Pa was found in the right-handed group but not in the left-handed group. This study provides evidence that handedness is associated with AMLR components in frontocentral and hemispheric ROI. Handedness should be considered an essential factor in the clinical or experimental use of AMLRs.

  1. Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).

    Science.gov (United States)

    Oi, Ami; Katayama, Syouichi; Hatano, Naoya; Sugiyama, Yasunori; Kameshita, Isamu; Sueyoshi, Noriyuki

    2017-01-08

    Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase primarily expressed in the central nervous system and is known to cause X-linked neurodevelopmental disorders such as Rett syndrome. However, the mechanisms regulating CDKL5 have not yet been fully clarified. Therefore, in this study, we investigated the protein kinase that directly phosphorylates CDKL5, identifying it as dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), an enzyme binding to and phosphorylating CDKL5. We showed that subcellular distribution of CDKL5 was regulated by its phosphorylation by DYRK1A. In mouse neuroblastoma Neuro2a cells, CDKL5 was localized in both the cytosol and nucleus, whereas DYRK1A showed a typical nuclear localization. When CDKL5 and DYRK1A were co-expressed, the cytosolic localization of CDKL5 was significantly increased. Results of site-directed mutagenesis revealed that the phosphorylation site was Ser-308, in the vicinity of the nuclear localization signal. A mutation mimicking the phosphorylated serine residue by aspartate substitution (S308D) changed CDKL5 localization to the cytosol, whereas the corresponding alanine-substituted analog, CDKL5(S308A), was primarily localized to the nucleus. Taken together, these results strongly suggested that DYRK1A bound to CDKL5 and phosphorylated it on Ser-308, thus interfering with its nuclear localization. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. ShakeCast: Automating and Improving the Use of ShakeMap for Post-Earthquake Decision- Making and Response

    Science.gov (United States)

    Lin, K.; Wald, D. J.

    2007-12-01

    ShakeCast is a freely available, post-earthquake situational awareness application that automatically retrieves earthquake shaking data from ShakeMap, compares intensity measures against users" facilities, sends notifications of potential damage to responsible parties, and generates facility damage maps and other Web-based products for emergency managers and responders. ShakeMap, a tool used to portray the extent of potentially damaging shaking following an earthquake, provides overall information regarding the affected areas. When a potentially damaging earthquake occurs, utility and other lifeline managers, emergency responders, and other critical users have an urgent need for information about the impact on their particular facilities so they can make appropriate decisions and take quick actions to ensure safety and restore system functionality. To this end, ShakeCast estimates the potential damage to a user's widely distributed facilities by comparing the complex shaking distribution with the potentially highly variable damageability of their inventory to provide a simple, hierarchical list and maps showing structures or facilities most likely impacted. All ShakeMap and ShakeCast files and products are non-propriety to simplify interfacing with existing users" response tools and to encourage user-made enhancement to the software. ShakeCast uses standard RSS and HTTP requests to communicate with the USGS Web servers that host ShakeMaps, which are widely-distributed and heavily mirrored. The RSS approach allows ShakeCast users to initiate and receive selected ShakeMap products and information on software updates. To assess facility damage estimates, ShakeCast users can combine measured or estimated ground motion parameters with damage relationships that can be pre-computed, use one of these ground motion parameters as input, and produce a multi-state discrete output of damage likelihood. Presently three common approaches are being used to provide users with an

  3. Re-examine tumor-induced alterations in hemodynamic responses of BOLD fMRI. Implications in presurgical brain mapping

    International Nuclear Information System (INIS)

    Wang, Liya; Ali, Shazia; Fa, Tianning; Mao, Hui; Dandan, Chen; Olson, Jeffrey

    2012-01-01

    Background: Blood oxygenation level dependent (BOLD) fMRI is used for presurgical functional mapping of brain tumor patients. Abnormal tumor blood supply may affect hemodynamic responses and BOLD fMRI signals. Purpose: To perform a multivariate and quantitative investigation of the effect of brain tumors on the hemodynamic responses and its impact on BOLD MRI signal time course, data analysis in order to better understand tumor-induced alterations in hemodynamic responses, and accurately mapping cortical regions in brain tumor patients. Material and Methods: BOLD fMRI data from 42 glioma patients who underwent presurgical mapping of the primary motor cortex (PMC) with a block designed finger tapping paradigm were analyzed, retrospectively. Cases were divided into high grade (n = 24) and low grade (n = 18) groups based on pathology. The tumor volume and distance to the activated PMCs were measured. BOLD signal time courses from selected regions of interest (ROIs) in the PMCs of tumor affected and contralateral unaffected hemispheres were obtained from each patient. Tumor-induced changes of BOLD signal intensity and time to peak (TTP) of BOLD signal time courses were analyzed statistically. Results: The BOLD signal intensity and TTP in the tumor-affected PMCs are altered when compared to that of the unaffected hemisphere. The average BOLD signal level is statistically significant lower in the affected PMCs. The average TTP in the affected PMCs is shorter in the high grade group, but longer in the low grade tumor group compared to the contralateral unaffected hemisphere. Degrees of alterations in BOLD signal time courses are related to both the distance to activated foci and tumor volume with the stronger effect in tumor distance to activated PMC. Conclusion: Alterations in BOLD signal time courses are strongly related to the tumor grade, the tumor volume, and the distance to the activated foci. Such alterations may impair accurate mapping of tumor-affected functional

  4. The creation of a South African climate map for the quantification of appropriate passive design responses

    CSIR Research Space (South Africa)

    Conradie, Dirk CU

    2012-06-01

    Full Text Available . The model was then extended to reflect expected South African climate changes over the next 100 years to synthetically create weather files for predicting building performance of existing and new buildings in the future. Using the new climatic map, several...

  5. Quantitative Chemical-Genetic Interaction Map Connects Gene Alterations to Drug Responses | Office of Cancer Genomics

    Science.gov (United States)

    In a recent Cancer Discovery report, CTD2 researchers at the University of California in San Francisco developed a new quantitative chemical-genetic interaction mapping approach to evaluate drug sensitivity or resistance in isogenic cell lines. Performing a high-throughput screen with isogenic cell lines allowed the researchers to explore the impact of a panel of emerging and established drugs on cells overexpressing a single cancer-associated gene in isolation.

  6. The Amoebal MAP Kinase Response to Legionella pneumophila Is Regulated by DupA

    OpenAIRE

    Li, Zhiru; Dugan, Aisling S.; Bloomfield, Gareth; Skelton, Jason; Ivens, Alasdair; Losick, Vicki; Isberg, Ralph R.

    2009-01-01

    The amoeba Dictyostelium discoideum can support replication of Legionella pneumophila. Here we identify the dupA gene, encoding a putative tyrosine kinase/dual-specificity phosphatase, in a screen for D. discoideum mutants altered in allowing L. pneumophila intracellular replication. Inactivation of dupA resulted in depressed L. pneumophila growth and sustained hyperphosphorylation of the amoebal MAP kinase ERK1, consistent with loss of a phosphatase activity. Bacterial challenge of wild-type...

  7. High-throughput mapping of brain-wide activity in awake and drug-responsive vertebrates.

    Science.gov (United States)

    Lin, Xudong; Wang, Shiqi; Yu, Xudong; Liu, Zhuguo; Wang, Fei; Li, Wai Tsun; Cheng, Shuk Han; Dai, Qiuyun; Shi, Peng

    2015-02-07

    The reconstruction of neural activity across complete neural circuits, or brain activity mapping, has great potential in both fundamental and translational neuroscience research. Larval zebrafish, a vertebrate model, has recently been demonstrated to be amenable to whole brain activity mapping in behaving animals. Here we demonstrate a microfluidic array system ("Fish-Trap") that enables high-throughput mapping of brain-wide activity in awake larval zebrafish. Unlike the commonly practiced larva-processing methods using a rigid gel or a capillary tube, which are laborious and time-consuming, the hydrodynamic design of our microfluidic chip allows automatic, gel-free, and anesthetic-free processing of tens of larvae for microscopic imaging with single-cell resolution. Notably, this system provides the capability to directly couple pharmaceutical stimuli with real-time recording of neural activity in a large number of animals, and the local and global effects of pharmacoactive drugs on the nervous system can be directly visualized and evaluated by analyzing drug-induced functional perturbation within or across different brain regions. Using this technology, we tested a set of neurotoxin peptides and obtained new insights into how to exploit neurotoxin derivatives as therapeutic agents. The novel and versatile "Fish-Trap" technology can be readily unitized to study other stimulus (optical, acoustic, or physical) associated functional brain circuits using similar experimental strategies.

  8. Mapping and characterization of positive and negative BOLD responses to visual stimulation in multiple brain regions at 7T.

    Science.gov (United States)

    Jorge, João; Figueiredo, Patrícia; Gruetter, Rolf; van der Zwaag, Wietske

    2018-02-20

    External stimuli and tasks often elicit negative BOLD responses in various brain regions, and growing experimental evidence supports that these phenomena are functionally meaningful. In this work, the high sensitivity available at 7T was explored to map and characterize both positive (PBRs) and negative BOLD responses (NBRs) to visual checkerboard stimulation, occurring in various brain regions within and beyond the visual cortex. Recently-proposed accelerated fMRI techniques were employed for data acquisition, and procedures for exclusion of large draining vein contributions, together with ICA-assisted denoising, were included in the analysis to improve response estimation. Besides the visual cortex, significant PBRs were found in the lateral geniculate nucleus and superior colliculus, as well as the pre-central sulcus; in these regions, response durations increased monotonically with stimulus duration, in tight covariation with the visual PBR duration. Significant NBRs were found in the visual cortex, auditory cortex, default-mode network (DMN) and superior parietal lobule; NBR durations also tended to increase with stimulus duration, but were significantly less sustained than the visual PBR, especially for the DMN and superior parietal lobule. Responses in visual and auditory cortex were further studied for checkerboard contrast dependence, and their amplitudes were found to increase monotonically with contrast, linearly correlated with the visual PBR amplitude. Overall, these findings suggest the presence of dynamic neuronal interactions across multiple brain regions, sensitive to stimulus intensity and duration, and demonstrate the richness of information obtainable when jointly mapping positive and negative BOLD responses at a whole-brain scale, with ultra-high field fMRI. © 2018 Wiley Periodicals, Inc.

  9. Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)

    International Nuclear Information System (INIS)

    Oi, Ami; Katayama, Syouichi; Hatano, Naoya; Sugiyama, Yasunori; Kameshita, Isamu; Sueyoshi, Noriyuki

    2017-01-01

    Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase primarily expressed in the central nervous system and is known to cause X-linked neurodevelopmental disorders such as Rett syndrome. However, the mechanisms regulating CDKL5 have not yet been fully clarified. Therefore, in this study, we investigated the protein kinase that directly phosphorylates CDKL5, identifying it as dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), an enzyme binding to and phosphorylating CDKL5. We showed that subcellular distribution of CDKL5 was regulated by its phosphorylation by DYRK1A. In mouse neuroblastoma Neuro2a cells, CDKL5 was localized in both the cytosol and nucleus, whereas DYRK1A showed a typical nuclear localization. When CDKL5 and DYRK1A were co-expressed, the cytosolic localization of CDKL5 was significantly increased. Results of site-directed mutagenesis revealed that the phosphorylation site was Ser-308, in the vicinity of the nuclear localization signal. A mutation mimicking the phosphorylated serine residue by aspartate substitution (S308D) changed CDKL5 localization to the cytosol, whereas the corresponding alanine-substituted analog, CDKL5(S308A), was primarily localized to the nucleus. Taken together, these results strongly suggested that DYRK1A bound to CDKL5 and phosphorylated it on Ser-308, thus interfering with its nuclear localization. - Highlights: • We investigated the mechanism regulating subcellular localization of CDKL5. • DYRK1A was identified as an enzyme that bound to and phosphorylated CDKL5. • The phosphorylation site of CDKL5 was Ser-308, in the vicinity of the NLS. • When DYRK1A was co-expressed, the cytosolic CDKL5 was significantly increased. • In conclusion, DYRK1A regulates CDKL5 localization via phosphorylation on Ser-308.

  10. A generalized parametric response mapping method for analysis of multi-parametric imaging: A feasibility study with application to glioblastoma.

    Science.gov (United States)

    Lausch, Anthony; Yeung, Timothy Pok-Chi; Chen, Jeff; Law, Elton; Wang, Yong; Urbini, Benedetta; Donelli, Filippo; Manco, Luigi; Fainardi, Enrico; Lee, Ting-Yim; Wong, Eugene

    2017-11-01

    Parametric response map (PRM) analysis of functional imaging has been shown to be an effective tool for early prediction of cancer treatment outcomes and may also be well-suited toward guiding personalized adaptive radiotherapy (RT) strategies such as sub-volume boosting. However, the PRM method was primarily designed for analysis of longitudinally acquired pairs of single-parameter image data. The purpose of this study was to demonstrate the feasibility of a generalized parametric response map analysis framework, which enables analysis of multi-parametric data while maintaining the key advantages of the original PRM method. MRI-derived apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) maps acquired at 1 and 3-months post-RT for 19 patients with high-grade glioma were used to demonstrate the algorithm. Images were first co-registered and then standardized using normal tissue image intensity values. Tumor voxels were then plotted in a four-dimensional Cartesian space with coordinate values equal to a voxel's image intensity in each of the image volumes and an origin defined as the multi-parametric mean of normal tissue image intensity values. Voxel positions were orthogonally projected onto a line defined by the origin and a pre-determined response vector. The voxels are subsequently classified as positive, negative or nil, according to whether projected positions along the response vector exceeded a threshold distance from the origin. The response vector was selected by identifying the direction in which the standard deviation of tumor image intensity values was maximally different between responding and non-responding patients within a training dataset. Voxel classifications were visualized via familiar three-class response maps and then the fraction of tumor voxels associated with each of the classes was investigated for predictive utility analogous to the original PRM method. Independent PRM and MPRM analyses of the contrast

  11. Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli.

    Directory of Open Access Journals (Sweden)

    Melody K Morris

    2011-03-01

    Full Text Available Predictive understanding of cell signaling network operation based on general prior knowledge but consistent with empirical data in a specific environmental context is a current challenge in computational biology. Recent work has demonstrated that Boolean logic can be used to create context-specific network models by training proteomic pathway maps to dedicated biochemical data; however, the Boolean formalism is restricted to characterizing protein species as either fully active or inactive. To advance beyond this limitation, we propose a novel form of fuzzy logic sufficiently flexible to model quantitative data but also sufficiently simple to efficiently construct models by training pathway maps on dedicated experimental measurements. Our new approach, termed constrained fuzzy logic (cFL, converts a prior knowledge network (obtained from literature or interactome databases into a computable model that describes graded values of protein activation across multiple pathways. We train a cFL-converted network to experimental data describing hepatocytic protein activation by inflammatory cytokines and demonstrate the application of the resultant trained models for three important purposes: (a generating experimentally testable biological hypotheses concerning pathway crosstalk, (b establishing capability for quantitative prediction of protein activity, and (c prediction and understanding of the cytokine release phenotypic response. Our methodology systematically and quantitatively trains a protein pathway map summarizing curated literature to context-specific biochemical data. This process generates a computable model yielding successful prediction of new test data and offering biological insight into complex datasets that are difficult to fully analyze by intuition alone.

  12. Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis.

    Science.gov (United States)

    Singh, Rahul; Beasley, Rachel; Long, Thavy; Caffrey, Conor R

    2018-01-01

    Neglected tropical diseases, especially those caused by helminths, constitute some of the most common infections of the world's poorest people. Amongst these, schistosomiasis (bilharzia or 'snail fever'), caused by blood flukes of the genus Schistosoma, ranks second only to malaria in terms of human impact: two hundred million people are infected and close to 800 million are at risk of infection. Drug screening against helminths poses unique challenges: the parasite cannot be cloned and is difficult to target using gene knockouts or RNAi. Consequently, both lead identification and validation involve phenotypic screening, where parasites are exposed to compounds whose effects are determined through the analysis of the ensuing phenotypic responses. The efficacy of leads thus identified derives from one or more or even unknown molecular mechanisms of action. The two most immediate and significant challenges that confront the state-of-the-art in this area are: the development of automated and quantitative phenotypic screening techniques and the mapping and quantitative characterization of the totality of phenotypic responses of the parasite. In this paper, we investigate and propose solutions for the latter problem in terms of the following: (1) mathematical formulation and algorithms that allow rigorous representation of the phenotypic response space of the parasite, (2) application of graph-theoretic and network analysis techniques for quantitative modeling and characterization of the phenotypic space, and (3) application of the aforementioned methodology to analyze the phenotypic space of S. mansoni - one of the etiological agents of schistosomiasis, induced by compounds that target its polo-like kinase 1 (PLK 1) gene - a recently validated drug target. In our approach, first, bio-image analysis algorithms are used to quantify the phenotypic responses of different drugs. Next, these responses are linearly mapped into a low- dimensional space using Principle

  13. Preparedness for response to the challenges from orphan sources: nationwide environmental radiation mapping with state of the art monitoring systems

    International Nuclear Information System (INIS)

    Saindane, Shashank S.; Pradeepkumar, K.S.; Suri, M.M.K.; Sharma, D.N.

    2008-01-01

    Based on the various international reports on orphan sources, the potential for radiological emergencies in public domain is recognized as a cause of concern. To detect the presence of any such orphan sources and to strengthen the preparedness for response to any radiological emergencies in public domain, a nationwide radiation mapping programme was initiated in India. Various radiation monitoring systems, few of them integrated with Global Positioning System (GPS) installed in mobile monitoring vans were used for this purpose. This monitoring also helped in generating the base line dose rate data of the cities and also in demonstrating the methodology of environmental monitoring for locating the presence of orphan sources, if any. During the detailed monitoring of various cities of the country, different systems such as GSM based Radiation Monitoring System (GRaMS), Compact Radiation Monitoring system, Portable Mobile Gamma Spectrometry System, Gamma Tracer System etc. installed in a vehicle were made to continuously acquire the data at a varying rate from 10 sec to 1 minute acquisition time. These systems can measure dose rate in the range of 0.01 - 100 μGy h -1 and can detect 7.4 MBq (200 μCi) of 60 Co and 25 MBq (675 μCi) of 137 Cs from a distance of 5 metre. Average dose rate recorded during these environmental monitoring was 81 ± 07 nGy h -1 with a maximum of 210 ± 11 nGyh -1 at Bangalore (attributed to the presence of K-40). The digital topographic map and the data acquired from the radiation mapping are used to generate terrestrial radiation map. This radiation profile stored in the database can be used as reference while carrying out the impact assessment following any nuclear / radiological emergencies. These systems also help to tag the radiation levels along with positional coordinates online onto the GIS map of the area. GRaMS also demonstrated its capability for online transmission of the data to the centralized data acquisition Base Station

  14. From Pixels to Response Maps: Discriminative Image Filtering for Face Alignment in the Wild

    NARCIS (Netherlands)

    Asthana, Akshay; Asthana, Ashish; Zafeiriou, Stefanos; Tzimiropoulos, Georgios; Cheng, Shiyang; Pantic, Maja

    2015-01-01

    We propose a face alignment framework that relies on the texture model generated by the responses of discriminatively trained part-based filters. Unlike standard texture models built from pixel intensities or responses generated by generic filters (e.g. Gabor), our framework has two important

  15. Coincidence in map positions between pathogen-induced defense-responsive genes and quantitative resistance loci in rice

    Institute of Scientific and Technical Information of China (English)

    熊敏; 王石平; 张启发

    2002-01-01

    Quantitative disease resistance conferred by quantitative trait loci (QTLs) is presumably of wider spectrum and durable. Forty-four cDNA clones, representing 44 defense-responsive genes, were fine mapped to 56 loci distributed on 9 of the 12 rice chromosomes. The locations of 32 loci detected by 27 cDNA clones were associated with previously identified resistance QTLs for different rice diseases, including blast, bacterial blight, sheath blight and yellow mottle virus. The loci detected by the same multiple-copy cDNA clones were frequently located on similar locations of different chromosomes. Some of the multiple loci detected by the same clones were all associated with resistance QTLs. These results suggest that some of the genes may be important components in regulation of defense responses against pathogen invasion and they may be the candidates for studying the mechanism of quantitative disease resistance in rice.

  16. DoOR 2.0 - Comprehensive Mapping of Drosophila melanogaster Odorant Responses

    Science.gov (United States)

    Münch, Daniel; Galizia, C. Giovanni

    2016-02-01

    Odors elicit complex patterns of activated olfactory sensory neurons. Knowing the complete olfactome, i.e. the responses in all sensory neurons for all relevant odorants, is desirable to understand olfactory coding. The DoOR project combines all available Drosophila odorant response data into a single consensus response matrix. Since its first release many studies were published: receptors were deorphanized and several response profiles were expanded. In this study, we add unpublished data to the odor-response profiles for four odorant receptors (Or10a, Or42b, Or47b, Or56a). We deorphanize Or69a, showing a broad response spectrum with the best ligands including 3-hydroxyhexanoate, alpha-terpineol, 3-octanol and linalool. We include all of these datasets into DoOR, provide a comprehensive update of both code and data, and new tools for data analyses and visualizations. The DoOR project has a web interface for quick queries (http://neuro.uni.kn/DoOR), and a downloadable, open source toolbox written in R, including all processed and original datasets. DoOR now gives reliable odorant-responses for nearly all Drosophila olfactory responding units, listing 693 odorants, for a total of 7381 data points.

  17. Cluster analysis of quantitative parametric maps from DCE-MRI: application in evaluating heterogeneity of tumor response to antiangiogenic treatment.

    Science.gov (United States)

    Longo, Dario Livio; Dastrù, Walter; Consolino, Lorena; Espak, Miklos; Arigoni, Maddalena; Cavallo, Federica; Aime, Silvio

    2015-07-01

    The objective of this study was to compare a clustering approach to conventional analysis methods for assessing changes in pharmacokinetic parameters obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during antiangiogenic treatment in a breast cancer model. BALB/c mice bearing established transplantable her2+ tumors were treated with a DNA-based antiangiogenic vaccine or with an empty plasmid (untreated group). DCE-MRI was carried out by administering a dose of 0.05 mmol/kg of Gadocoletic acid trisodium salt, a Gd-based blood pool contrast agent (CA) at 1T. Changes in pharmacokinetic estimates (K(trans) and vp) in a nine-day interval were compared between treated and untreated groups on a voxel-by-voxel analysis. The tumor response to therapy was assessed by a clustering approach and compared with conventional summary statistics, with sub-regions analysis and with histogram analysis. Both the K(trans) and vp estimates, following blood-pool CA injection, showed marked and spatial heterogeneous changes with antiangiogenic treatment. Averaged values for the whole tumor region, as well as from the rim/core sub-regions analysis were unable to assess the antiangiogenic response. Histogram analysis resulted in significant changes only in the vp estimates (pclustering approach depicted marked changes in both the K(trans) and vp estimates, with significant spatial heterogeneity in vp maps in response to treatment (pclustered in three or four sub-regions. This study demonstrated the value of cluster analysis applied to pharmacokinetic DCE-MRI parametric maps for assessing tumor response to antiangiogenic therapy. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. DupA: a key regulator of the amoebal MAP kinase response to Legionella pneumophila

    Science.gov (United States)

    Li, Zhiru; Dugan, Aisling S.; Bloomfield, Gareth; Skelton, Jason; Ivens, Alasdair; Losick, Vicki; Isberg, Ralph R.

    2009-01-01

    SUMMARY The dupA gene, encoding a putative tyrosine kinase/dual specificity phosphatase (Dusp), was identified in a screen for Dictyostelium discoideum mutants altered in supporting Legionella pneumophila intracellular replication. The absence of dupA resulted in hyperphosphorylation of ERK1, consistent with the loss of a phosphatase activity, as well as degradation of ERK2. ERK1 hyperphosphorylation mimicked the response of this protein after bacterial challenge of wild type amoebae. Similar to Dusps in higher eukaryotic cells, the amoebal dupA gene was induced after bacterial contact, indicating a response of Dusps that is conserved from amoebae to mammals. A large set of genes was misregulated in the dupA− mutant that largely overlaps with genes responding to L. pneumophila infection. Some of the amoebal genes appear to be involved in a response similar to innate immunity in higher eukaryotes, indicating there was misregulation of a conserved response to bacteria. PMID:19748467

  19. Parametric response mapping of dynamic CT for predicting intrahepatic recurrence of hepatocellular carcinoma after conventional transcatheter arterial chemoembolization

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Seung Joon; Kim, Hyung Sik [Gachon University Gil Hospital, Department of Radiology, Incheon (Korea, Republic of); Kim, Jonghoon [Sungkyunkwan University, Department of Electronic Electrical and Computer Engineering, Suwon (Korea, Republic of); Seo, Jongbum [Yonsei University, Department of Biomedical Engineering, Wonju (Korea, Republic of); Lee, Jong-min [Hanyang University, Department of Biomedical Engineering, Seoul (Korea, Republic of); Park, Hyunjin [Sungkyunwkan University, School of Electronic and Electrical Engineering, Suwon (Korea, Republic of)

    2016-01-15

    The aim of our study was to determine the diagnostic value of a novel image analysis method called parametric response mapping (PRM) for prediction of intrahepatic recurrence of hepatocellular carcinoma (HCC) treated with conventional transcatheter arterial chemoembolization (TACE). This retrospective study was approved by the IRB. We recruited 55 HCC patients who achieved complete remission (CR) after TACE and received longitudinal multiphasic liver computed tomography (CT). The patients fell into two groups: the recurrent tumour group (n = 29) and the non-recurrent tumour group (n = 26). We applied the PRM analysis to see if this technique could distinguish between the two groups. The results of the PRM analysis were incorporated into a prediction algorithm. We retrospectively removed data from the last time point and attempted to predict the response to therapy of the removed data. The PRM analysis was able to distinguish between the non-recurrent and recurrent groups successfully. The prediction algorithm detected response to therapy with an area under the curve (AUC) of 0.76, while the manual approach had AUC 0.64. Adopting PRM analysis can potentially distinguish between recurrent and non-recurrent HCCs and allow for prediction of response to therapy after TACE. (orig.)

  20. Parametric response mapping of contrast-enhanced biphasic CT for evaluating tumour viability of hepatocellular carcinoma after TACE

    Energy Technology Data Exchange (ETDEWEB)

    Hinrichs, Jan B.; Shin, Hoen-Oh; Kaercher, Daniel; Hasdemir, Davut; Kaireit, Till; Lutat, Carolin; Meyer, Bernhard C.; Wacker, Frank K.; Rodt, Thomas [Hannover Medical School, Department of Diagnostic and Interventional Radiology, Hannover (Germany); Murray, Tim [Beaumont Hospital, Department of Diagnostic and Interventional Radiology, Dublin (Ireland); Vogel, Arndt [Hannover Medical School, Gastroenterology, Hepatology and Endocrinology, Hannover (Germany)

    2016-10-15

    To determine the feasibility and role of parametric response mapping (PRM) for quantitative assessment of regional contrast-enhancement patterns in hepatocellular carcinoma (HCC). Biphasic CT of 19 patients receiving repetitive conventional transarterial chemoembolisation (cTACE) for intermediate stage HCC were retrospectively analysed at baseline and follow-up at 3, 6, and 9 months. Voxel-based registration of arterial and porto-venous phases, with segmentation of the largest target lesion was performed. Frequency distribution plots of density-pairs of segmented voxels were generated. To differentiate necrotic, hypervascular and non-hypervascular tumour, and lipiodol/calcification, thresholds of 30, 100, and 300 HU were applied. Changes in density frequency plots over time were analysed and compared to response and assessment criteria (WHO, RECIST, EASL, mRECIST) and survival. PRM was feasible in all cases. Tumour volumes and hypervascular/non-hypervascular volume ratio showed significant longitudinal decrease (p < 0.05). Hypervascular volume at baseline was inversely correlated to survival (R = -0.57, p = 0.005). The only predictive parameter following cTACE to show significant survival difference was the change of the viable/non-viable ratio (p = 0.044), whereas common response assessment criteria showed no significant difference in survival. PRM allows a quantitative and more precise assessment of regional tumour vascularisation patterns and may be helpful for TACE treatment planning and response assessment. (orig.)

  1. 2-D response mapping of multi-linear silicon drift detectors

    International Nuclear Information System (INIS)

    Castoldi, A.; Guazzoni, C.; Hartmann, R.; Mezza, D.; Strueder, L.; Tassan Garofolo, F.

    2010-01-01

    Multi-linear silicon drift detectors (MLSDDs) are good candidates to fulfill simultaneous requirements for 2-D position-sensing and spectroscopy applications. The optimization of their design and performance as 2-D imagers requires a detailed study of timing properties of the charge cloud in the MLSDD architecture. In particular it is important to experimentally determine the dependence of the measured amplitude and time-of-arrival on the photon position of interaction so as to derive the 2D detector response. In this paper we will present a detailed experimental characterization aimed at measuring the detector amplitude response and its timing response. The dependence of charge cloud drift time on precise position of interaction has been measured as a function of detector biasing conditions.

  2. From Pixels to Response Maps: Discriminative Image Filtering for Face Alignment in the Wild.

    Science.gov (United States)

    Asthana, Akshay; Zafeiriou, Stefanos; Tzimiropoulos, Georgios; Cheng, Shiyang; Pantic, Maja

    2015-06-01

    We propose a face alignment framework that relies on the texture model generated by the responses of discriminatively trained part-based filters. Unlike standard texture models built from pixel intensities or responses generated by generic filters (e.g. Gabor), our framework has two important advantages. First, by virtue of discriminative training, invariance to external variations (like identity, pose, illumination and expression) is achieved. Second, we show that the responses generated by discriminatively trained filters (or patch-experts) are sparse and can be modeled using a very small number of parameters. As a result, the optimization methods based on the proposed texture model can better cope with unseen variations. We illustrate this point by formulating both part-based and holistic approaches for generic face alignment and show that our framework outperforms the state-of-the-art on multiple "wild" databases. The code and dataset annotations are available for research purposes from http://ibug.doc.ic.ac.uk/resources.

  3. Sexual Assault Response Teams (SARTs): mapping a research agenda that incorporates an organizational perspective.

    Science.gov (United States)

    Moylan, Carrie A; Lindhorst, Taryn; Tajima, Emiko A

    2015-04-01

    Multidisciplinary coordinated Sexual Assault Response Teams (SARTs) are a growing model of providing health, legal, and emotional support services to victims of sexual assault. This article conceptualizes SARTs from an organizational perspective and explores three approaches to researching SARTs that have the potential of increasing our understanding of the benefits and challenges of multidisciplinary service delivery. These approaches attend to several levels of organizational behavior, including the organizational response to external legitimacy pressures, the inter-organizational networks of victim services, and the negotiation of power and disciplinary boundaries. Possible applications to organizational research on SARTs are explored. © The Author(s) 2015.

  4. MAP Kinase Cascades Regulate the Cold Response by Modulating ICE1 Protein Stability.

    Science.gov (United States)

    Zhao, Chunzhao; Wang, Pengcheng; Si, Tong; Hsu, Chuan-Chih; Wang, Lu; Zayed, Omar; Yu, Zheping; Zhu, Yingfang; Dong, Juan; Tao, W Andy; Zhu, Jian-Kang

    2017-12-04

    Mitogen-activated protein kinase cascades are important signaling modules that convert environmental stimuli into cellular responses. We show that MPK3, MPK4, and MPK6 are rapidly activated after cold treatment. The mpk3 and mpk6 mutants display increased expression of CBF genes and enhanced freezing tolerance, whereas constitutive activation of the MKK4/5-MPK3/6 cascade in plants causes reduced expression of CBF genes and hypersensitivity to freezing, suggesting that the MKK4/5-MPK3/6 cascade negatively regulates the cold response. MPK3 and MPK6 can phosphorylate ICE1, a basic-helix-loop-helix transcription factor that regulates the expression of CBF genes, and the phosphorylation promotes the degradation of ICE1. Interestingly, the MEKK1-MKK2-MPK4 pathway constitutively suppresses MPK3 and MPK6 activities and has a positive role in the cold response. Furthermore, the MAPKKK YDA and two calcium/calmodulin-regulated receptor-like kinases, CRLK1 and CRLK2, negatively modulate the cold activation of MPK3/6. Our results uncover important roles of MAPK cascades in the regulation of plant cold response. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Text analysis of open-ended survey responses : a complementary method to preference mapping

    NARCIS (Netherlands)

    ten Kleij, F; Musters, PAD

    The present study illustrates the use of computer-aided text analysis to evaluate the content of open-ended survey responses. During an in-hall test, different varieties of mayonnaise were evaluated by 165 respondents on a 10-point liking scale, with the option to freely comment on these

  6. Unfolded Protein Response Signaling and MAP Kinase Pathways Underlie Pathogenesis of Arsenic-induced Cutaneous Inflammation

    OpenAIRE

    Li, Changzhao; Xu, Jianmin; Li, Fugui; Chaudhary, Sandeep C.; Weng, Zhiping; Wen, Jianming; Elmets, Craig A.; Ahsan, Habibul; Athar, Mohammad

    2011-01-01

    Arsenic exposure through drinking water is a major global public health problem and is associated with an enhanced risk of various cancers including skin cancer. In human skin, arsenic induces precancerous melanosis and keratosis, which may progress to basal cell and squamous cell carcinoma. However, the mechanism by which these pathophysiological alterations occur remains elusive. In this study, we showed that sub-chronic arsenic exposure to SKH-1 mice induced unfolded protein response (UPR)...

  7. BRIC-17 Mapping Spaceflight-Induced Hypoxic Signaling and Response in Plants

    Science.gov (United States)

    Gilroy, Simon; Choi, Won-Gyu; Swanson, Sarah

    2012-01-01

    Goals of this work are: (1) Define global changes in gene expression patterns in Arabidopsis plants grown in microgravity using whole genome microarrays (2) Compare to mutants resistant to low oxygen challenge using whole genome microarrays Also measuring root and shoot size Outcomes from this research are: (1) Provide fundamental information on plant responses to the stresses inherent in spaceflight (2) Potential for informing on genetic strategies to engineer plants for optimal growth in space

  8. Relocation due to Climate Change: Mapping the Divergent Responses of the Governments of Tuvalu and Kiribati

    Science.gov (United States)

    McNamara, K. E.; Hemstock, S.; Smith, R.; Holland, E. A.

    2012-12-01

    Climate change will continue to impact Pacific Island livelihoods in diverse and complex ways. At the 2009 Copenhagen Conference of Parties to discuss the United Nations Framework Convention on Climate Change, Pacific governments argued for the need to limit warming to 1.5°C. A growing body of literature demonstrates that warming beyond this 2°C threshold is likely and will result in numerous negative impacts on socio-ecological systems across the world, particularly for low-lying coastal communities (Parry et al, 2009; Smith et al, 2009). These communities will need to manage, if possible,a series of interconnected impacts, such as declining freshwater and food security and diminishing land availability, as a result of sea level rise and increasing extreme weather events (Adger and Barnett, 2009). Discussions concerning climate change as a trigger for relocation for low-lying Pacific nations have been contentious, and are fuelled by emotion and varying degrees of sensitivity. As Hayward-Jones (2010: 2) lamented: 'What is at stake over the next decade is not a sinking island but the very viability of life on this fragile atoll state. The land mass of Tuvalu will still exist in 2020 but it may be unable to support the population'. While this debate has historical roots, and indeed the phenomenon of relocation due to localised environmental degradation is not something new in the Pacific, it remains a significant contemporary issue. Scholars have argued that a 'successful mix of strategies' is required to develop culturally-appropriate solutions to this concern about the need for low-lying coastal communities in the Pacific to relocate (Bedford and Bedford, 2010: 93). As such, this paper assesses how the national governments of two low-lying nations in the Pacific - Tuvalu and Kiribati - are mapping out very different long-term strategies to respond to climate change impacts and concerns about the possibility of relocation. The governments of Tuvalu and Kiribati

  9. TU-C-12A-02: Development of a Multiparametric Statistical Response Map for Quantitative Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bosca, R [The University of Texas Graduate School of Biomedical Sciences, Houston, TX (United States); The University of Texas MD Anderson Cancer Center, Houston, TX (United States); Mahajan, A; Brown, PD; Stafford, RJ [The University of Texas MD Anderson Cancer Center, Houston, TX (United States); Johnson, VE [Texas A' M University, College Station, TX (United States); Dong, L [Scripps Proton Therapy Center, San Diego, CA (United States); Jackson, EF [University of Wisconsin, Madison, WI (United States)

    2014-06-15

    Purpose: Quantitative imaging biomarkers (QIB) are becoming increasingly utilized in early phase clinical trials as a means of non-invasively assessing treatment response and associated response heterogeneity. The aim of this study was to develop a flexible multiparametric statistical framework to predict voxel-by-voxel response of several potential MRI QIBs. Methods: Patients with histologically proven glioblastomas (n=11) were treated with chemoradiation (with/without bevacizumab) and underwent one baseline and two mid-treatment (3–4wks) MRIs. Dynamic contrast-enhanced (3D FSPGR, 6.3sec/phase, 0.1 mmol/kg Gd-DTPA), dynamic susceptibility contrast (2D GRE-EPI, 1.5sec/phase, 0.2mmol/kg Gd-DTPA), and diffusion tensor (2D DW-EPI, b=0, 1200 s/mm{sup 2}, 27 directions) imaging acquisitions were obtained during each study. Mid-treatment and pre-treatment images were rigidly aligned, and regions of partial response (PR), stable disease (SD), and progressive disease (PD) were contoured in consensus by two experienced radiation oncologists. Voxels in these categories were used to train ordinal (PR

  10. TU-C-12A-02: Development of a Multiparametric Statistical Response Map for Quantitative Imaging

    International Nuclear Information System (INIS)

    Bosca, R; Mahajan, A; Brown, PD; Stafford, RJ; Johnson, VE; Dong, L; Jackson, EF

    2014-01-01

    Purpose: Quantitative imaging biomarkers (QIB) are becoming increasingly utilized in early phase clinical trials as a means of non-invasively assessing treatment response and associated response heterogeneity. The aim of this study was to develop a flexible multiparametric statistical framework to predict voxel-by-voxel response of several potential MRI QIBs. Methods: Patients with histologically proven glioblastomas (n=11) were treated with chemoradiation (with/without bevacizumab) and underwent one baseline and two mid-treatment (3–4wks) MRIs. Dynamic contrast-enhanced (3D FSPGR, 6.3sec/phase, 0.1 mmol/kg Gd-DTPA), dynamic susceptibility contrast (2D GRE-EPI, 1.5sec/phase, 0.2mmol/kg Gd-DTPA), and diffusion tensor (2D DW-EPI, b=0, 1200 s/mm 2 , 27 directions) imaging acquisitions were obtained during each study. Mid-treatment and pre-treatment images were rigidly aligned, and regions of partial response (PR), stable disease (SD), and progressive disease (PD) were contoured in consensus by two experienced radiation oncologists. Voxels in these categories were used to train ordinal (PR

  11. Integration of anatomical and external response mappings explains crossing effects in tactile localization: A probabilistic modeling approach.

    Science.gov (United States)

    Badde, Stephanie; Heed, Tobias; Röder, Brigitte

    2016-04-01

    To act upon a tactile stimulus its original skin-based, anatomical spatial code has to be transformed into an external, posture-dependent reference frame, a process known as tactile remapping. When the limbs are crossed, anatomical and external location codes are in conflict, leading to a decline in tactile localization accuracy. It is unknown whether this impairment originates from the integration of the resulting external localization response with the original, anatomical one or from a failure of tactile remapping in crossed postures. We fitted probabilistic models based on these diverging accounts to the data from three tactile localization experiments. Hand crossing disturbed tactile left-right location choices in all experiments. Furthermore, the size of these crossing effects was modulated by stimulus configuration and task instructions. The best model accounted for these results by integration of the external response mapping with the original, anatomical one, while applying identical integration weights for uncrossed and crossed postures. Thus, the model explained the data without assuming failures of remapping. Moreover, performance differences across tasks were accounted for by non-individual parameter adjustments, indicating that individual participants' task adaptation results from one common functional mechanism. These results suggest that remapping is an automatic and accurate process, and that the observed localization impairments in touch result from a cognitively controlled integration process that combines anatomically and externally coded responses.

  12. Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment.

    Science.gov (United States)

    Rosenwasser, Shilo; Graff van Creveld, Shiri; Schatz, Daniella; Malitsky, Sergey; Tzfadia, Oren; Aharoni, Asaph; Levin, Yishai; Gabashvili, Alexandra; Feldmesser, Ester; Vardi, Assaf

    2014-02-18

    Diatoms are ubiquitous marine photosynthetic eukaryotes responsible for approximately 20% of global photosynthesis. Little is known about the redox-based mechanisms that mediate diatom sensing and acclimation to environmental stress. Here we used a quantitative mass spectrometry-based approach to elucidate the redox-sensitive signaling network (redoxome) mediating the response of diatoms to oxidative stress. We quantified the degree of oxidation of 3,845 cysteines in the Phaeodactylum tricornutum proteome and identified approximately 300 redox-sensitive proteins. Intriguingly, we found redox-sensitive thiols in numerous enzymes composing the nitrogen assimilation pathway and the recently discovered diatom urea cycle. In agreement with this finding, the flux from nitrate into glutamine and glutamate, measured by the incorporation of (15)N, was strongly inhibited under oxidative stress conditions. Furthermore, by targeting the redox-sensitive GFP sensor to various subcellular localizations, we mapped organelle-specific oxidation patterns in response to variations in nitrogen quota and quality. We propose that redox regulation of nitrogen metabolism allows rapid metabolic plasticity to ensure cellular homeostasis, and thus is essential for the ecological success of diatoms in the marine ecosystem.

  13. Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma.

    Directory of Open Access Journals (Sweden)

    Brian J Capaldo

    Full Text Available Fifty percent of cutaneous melanomas are driven by activated BRAFV600E, but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and develop drug combinations that target these resistance mechanisms. In a combinatorial drug screen on a panel of 12 treatment-naïve BRAFV600E mutant melanoma cell lines of varying levels of resistance to mitogen-activated protein kinase (MAPK pathway inhibition, we identified the combination of PLX4720, a targeted inhibitor of mutated BRaf, and lapatinib, an inhibitor of the ErbB family of receptor tyrosine kinases, as synergistically cytotoxic in the subset of cell lines that displayed the most resistance to PLX4720. To identify potential mechanisms of resistance to PLX4720 treatment and synergy with lapatinib treatment, we performed a multi-platform functional genomics analysis to profile the genome as well as the transcriptional and proteomic responses of these cell lines to treatment with PLX4720. We found modest levels of resistance correlated with the zygosity of the BRAF V600E allele and receptor tyrosine kinase (RTK mutational status. Layered over base-line resistance was substantial upregulation of many ErbB pathway genes in response to BRaf inhibition, thus generating the vulnerability to combination with lapatinib. The transcriptional responses of ErbB pathway genes are associated with a number of transcription factors, including ETS2 and its associated cofactors that represent a convergent regulatory mechanism conferring synergistic drug susceptibility in the context of diverse mutational landscapes.

  14. Metabolic mapping of the brain's response to visual stimulation: studies in humans

    International Nuclear Information System (INIS)

    Phelps, M.E.; Kuhl, D.E.; Mazziotta, J.C.

    1981-01-01

    These studies demonstrated increasing glucose metabolic rates in the human primary (PVC) and associative (AVC) visual cortex as the complexity of visual scenes increased. The metabolic response of the AVC increased more rapidly with scene complexity than that of the PVC, indicating the greater involvement of the higher order AVC for complex visual interpretations. Increases in local metabolic activity by as much as a factor of 2 above that of control subjects with eyes closed indicate the wide range and metabolic reserve of the visual cortex

  15. Stimulus-response mappings shape inhibition processes: a combined EEG-fMRI study of contextual stopping.

    Directory of Open Access Journals (Sweden)

    Christina F Lavallee

    Full Text Available Humans are rarely faced with one simple task, but are typically confronted with complex stimulus constellations and varying stimulus-relevance in a given situation. Through modifying the prototypical stop-signal task and by combined recording and analysis of electroencephalography (EEG and functional magnetic resonance imaging (fMRI, we studied the effects of stimulus relevance for the generation of a response or its inhibition. Stimulus response mappings were modified by contextual cues, indicating which of two different stimuli following a go stimulus was relevant for stopping. Overall, response inhibition, that is comparing successful stopping to a stop-signal against go-signal related processes, was associated with increased activity in right inferior and left midfrontal regions, as well as increased EEG delta and theta power; however, stimulus-response conditions in which the most infrequent stop-signal was relevant for inhibition, were associated with decreased activity in regions typically involved in response inhibition, as well as decreased activity in the delta and theta bands as compared to conditions wherein the relevant stop-signal frequency was higher. Behaviorally, this (aforementioned condition, which demanded inhibition only from the most infrequent stimulus, was also associated with reduced reaction times and lower error rates. This pattern of results does not align with typical stimulus frequency-driven findings and suggests interplay between task relevance and stimulus frequency of the stop-signal. Moreover, with a multimodal EEG-fMRI analysis, we demonstrated significant parameterization for response inhibition with delta, theta and beta time-frequency values, which may be interpreted as reflecting conflict monitoring, evaluative and/or motor processes as suggested by previous work (Huster et al., 2013; Aron, 2011. Further multimodal results suggest a possible neurophysiological and behavioral benefit under conditions

  16. Refined mapping of a quantitative trait locus on chromosome 1 responsible for mouse embryonic death.

    Directory of Open Access Journals (Sweden)

    Magalie Vatin

    Full Text Available Recurrent spontaneous abortion (RSA is defined as the loss of three or more consecutive pregnancies during the first trimester of embryonic intrauterine development. This kind of human infertility is frequent among the general population since it affects 1 to 5% of women. In half of the cases the etiology remains unelucidated. In the present study, we used interspecific recombinant congenic mouse strains (IRCS in the aim to identify genes responsible for embryonic lethality. Applying a cartographic approach using a genotype/phenotype association, we identified a minimal QTL region, of about 6 Mb on chromosome 1, responsible for a high rate of embryonic death (∼30%. Genetic analysis suggests that the observed phenotype is linked to uterine dysfunction. Transcriptomic analysis of the uterine tissue revealed a preferential deregulation of genes of this region compared to the rest of the genome. Some genes from the QTL region are associated with VEGF signaling, mTOR signaling and ubiquitine/proteasome-protein degradation pathways. This work may contribute to elucidate the molecular basis of a multifactorial and complex human disorder as RSA.

  17. Mapping of electrophysiological response to transcranial infrared laser stimulation on the human brain in vivo measured by electroencephalography (Conference Presentation)

    Science.gov (United States)

    Wang, Xinlong; Reddy, Divya Dhandapani; Gonzalez-Lima, F.; Liu, Hanli

    2017-02-01

    Transcranial infrared laser stimulation (TILS) is a non-destructive and non-thermal photobiomodulation therapy or process on the human brain; TILS uses infrared light from lasers or LEDs and has gained increased recognition for its beneficial effects on a variety of neurological and psychological conditions. While the mechanism of TILS has been assumed to stem from cytochrome-c-oxidase (CCO), which is the last enzyme in the electron transportation chain and is the primary photoacceptor, no literature is found to report electrophysiological response to TILS. In this study, a 64-channel electroencephalography (EEG) system was employed to monitor electrophysiological activities from 15 healthy human participants before, during and after TILS. A placebo experimental protocol was also applied for rigorous comparison. After recording a 3-minute baseline, we applied a 1064-nm laser with a power of 3.5W on the right forehead of each human participant for 8 minutes, followed by a 5-minute recovery period. In 64-channel EEG data analysis, we utilized several methods (root mean square, principal component analysis followed by independent component analysis, permutation conditional mutual information, and time-frequency wavelet analysis) to reveal differences in electrophysiological response to TILS between the stimulated versus placebo group. The analyzed results were further investigated using general linear model and paired t-test to reveal statistically meaningful responses induced by TILS. Moreover, this study will provide spatial mapping of human electrophysiological and possibly neural network responses to TILS for first time, indicating the potential of EEG to be an effective method for monitoring neurological improvement induced by TILS.

  18. MAPPING THE RELATIONSHIP BETWEEN REPUTATION ANDCORPORATE SOCIAL RESPONSIBILITY IN THE BANKING SECTOR: ACOMPREHENSIVE LITERATURE REVIEW

    Directory of Open Access Journals (Sweden)

    Annarita Trotta

    2013-01-01

    Full Text Available In recent years, an increasing number of scholars and practitioners have becomeinterested in the concepts of Corporate Reputation (CR and Corporate SocialResponsibility (CSR, examining them fromdifferent perspectives using severalapproaches.Some studies of the banking industry have emphasised the benefits ofpositive CR in achieving competitive advantages.Other studies have investigated the concept of CSR in the banking sector, exploring above all how CSR impactseconomic, financial and non-financial performance and focusing on the adoptionand disclosure of such initiatives (Callado-Munoz and Utrero-Gonzales,2011:755. However, this line ofinquiry is incomplete.In recent years, a growing number ofstudies have explored the relationshipbetween CR and CSR in non-financial sectors, but few studies have investigatedthe relationship in the banking industry. Although academic researches frequentlyconclude that CSR is an important reputational driver, Baldarelli and Gigli (2011point out that there is a lack of theoryand empirical evidence regarding the linkbetween CR and CSR, highlighting the need for further analysis. The academicdebate has so far failed to answer how responsibility and reputation interact.In the case of the banking industry, where there is no well-established tradition ofinvestigating either reputation or CSR, itis even more important to clarify therelationship between these two concepts. This may give rise to useful insightswith implications for management. Thisstudy aims to contribute to a betterunderstanding of the complex debate on these issues by developing an in-depthanalysis of the extant banking literature. Thus, our literature review has thefollowing aims: a to investigate the links between CR and CSR in the bankingindustry; b to critically explore thecharacteristics and methodologies of theprimary reputational and CSR measures; andc to suggest an agenda for futureresearch.The paper is structured as follows: the next section

  19. Rapid-response flood mapping during Hurricanes Harvey, Irma and Maria by the Global Flood Partnership (GFP)

    Science.gov (United States)

    Cohen, S.; Alfieri, L.; Brakenridge, G. R.; Coughlan, E.; Galantowicz, J. F.; Hong, Y.; Kettner, A.; Nghiem, S. V.; Prados, A. I.; Rudari, R.; Salamon, P.; Trigg, M.; Weerts, A.

    2017-12-01

    The Global Flood Partnership (GFP; https://gfp.jrc.ec.europa.eu) is a multi-disciplinary group of scientists, operational agencies and flood risk managers focused on developing efficient and effective global flood management tools. Launched in 2014, its aim is to establish a partnership for global flood forecasting, monitoring and impact assessment to strengthen preparedness and response and to reduce global disaster losses. International organizations, the private sector, national authorities, universities and research agencies contribute to the GFP on a voluntary basis and benefit from a global network focused on flood risk reduction. At the onset of Hurricane Harvey, GFP was `activated' using email requests via its mailing service. Soon after, flood inundation maps, based on remote sensing analysis and modeling, were shared by different agencies, institutions, and individuals. These products were disseminated, to varying degrees of effectiveness, to federal, state and local agencies via emails and data-sharing services. This generated a broad data-sharing network which was utilized at the early stages of Hurricane Irma's impact, just two weeks after Harvey. In this presentation, we will describe the extent and chronology of the GFP response to both Hurricanes Harvey, Irma and Maria. We will assess the potential usefulness of this effort for event managers in various types of organizations and discuss future improvements to be implemented.

  20. Science supporting Gulf of Mexico oil-spill response, mitigation, and restoration activities-Assessment, monitoring, mapping, and coordination

    Science.gov (United States)

    Kindinger, Jack; Tihansky, Ann B.; Cimitile, Matthew

    2011-01-01

    The St. Petersburg Coastal and Marine Science Center of the U.S. Geological Survey (USGS) investigates physical processes related to coastal and marine environments and societal implications related to natural hazards, resource sustainability, and environmental change. Immediately after the Deepwater Horizon event, the USGS began responding to data requests, directing response personnel, and providing coastal and shelf geophysical data to coastal-resource managers. The USGS provided oil-spill responders with up-to-date coastal bathymetry, geologic data, and maps characterizing vulnerability and levels of risk from potential spill impacts in Louisiana, Mississippi, and Alabama. Baseline conditions prior to any spill impacts were documented through programs that included shoreline sampling and sediment coring from east Texas to the east coast of Florida and aerial photography of many environmentally sensitive Gulf coastal areas. The USGS responded to numerous verbal and written data requests from Federal, State, and local partners and academic institutions with USGS scientific staff participating in the Coast Guard Unified Commands (UC) and Operational Science Advisory Teams (OSAT). The USGS conducted technical review of reports and plans for many response activities. Oil-spill responders, managers, and personnel on the ground, including partners such as the National Park Service, Gulf Islands National Seashore, Chandeleur Islands Refuge, and State agencies, continue to rely on USGS products.

  1. Mapping the Far Right: Geomedia in an Educational Response to Right-Wing Extremism

    Directory of Open Access Journals (Sweden)

    Thomas Jekel

    2017-09-01

    Full Text Available Across Europe, and probably the world, messages of the extreme right surface with increasing and alarming regularity in both public and virtual space. Within the virtual space, geomedia are increasingly used in nationalist propaganda, a trend which is embedded in a wider development in public discourse, election results, and policies. In Austria and Germany, particular sensibilities due to the responsibility for the Holocaust have developed, leading to various specific education initiatives that address this part of history. This paper presents an activist learning environment using geomedia to deconstruct right-wing extremist discourses, and has been tested used in university settings in Salzburg and Vienna. Using a combination of Instagram and geospatial technologies not visible to learners, results of reflection and learning processes are analyzed qualitatively across two slightly different enactments of the learning environment. Experiences suggest an encouraging potential of geomedia use in critical learning processes, as long as the technology is hidden from learners, forming an incentive, support, and contextualization of the learning process.

  2. The Role of Citizen Science in Risk Mitigation and Disaster Response: A Case Study of 2015 Nepalese Earthquake Using OpenStreetMap

    Science.gov (United States)

    Rieger, C.; Byrne, J. M.

    2015-12-01

    Citizen science includes networks of ordinary people acting as sensors, observing and recording information for science. OpenStreetMap is one such sensor network which empowers citizens to collaboratively produce a global picture from free geographic information. The success of this open source software is extended by the development of freely used open databases for the user community. Participating citizens do not require a high level of skill. Final results are processed by professionals following quality assurance protocols before map information is released. OpenStreetMap is not only the cheapest source of timely maps in many cases but also often the only source. This is particularly true in developing countries. Emergency responses to the recent earthquake in Nepal illustrates the value for rapidly updated geographical information. This includes emergency management, damage assessment, post-disaster response, and future risk mitigation. Local disaster conditions (landslides, road closings, bridge failures, etc.) were documented for local aid workers by citizen scientists working remotely. Satellites and drones provide digital imagery of the disaster zone and OpenStreetMap participants shared the data from locations around the globe. For the Nepal earthquake, OpenStreetMap provided a team of volunteers on the ground through their Humanitarian OpenStreetMap Team (HOT) which contribute data to the disaster response through smartphones and laptops. This, combined with global citizen science efforts, provided immediate geographically useful maps to assist aid workers, including the Red Cross and Canadian DART Team, and the Nepalese government. As of August 2014, almost 1.7 million users provided over 2.5 billion edits to the OpenStreetMap map database. Due to the increased usage of smartphones, GPS-enabled devices, and the growing participation in citizen science projects, data gathering is proving an effective way to contribute as a global citizen. This paper

  3. Ice Sheet Roughness Estimation Based on Impulse Responses Acquired in the Global Ice Sheet Mapping Orbiter Mission

    Science.gov (United States)

    Niamsuwan, N.; Johnson, J. T.; Jezek, K. C.; Gogineni, P.

    2008-12-01

    The Global Ice Sheet Mapping Orbiter (GISMO) mission was developed to address scientific needs to understand the polar ice subsurface structure. This NASA Instrument Incubator Program project is a collaboration between Ohio State University, the University of Kansas, Vexcel Corporation and NASA. The GISMO design utilizes an interferometric SAR (InSAR) strategy in which ice sheet reflected signals received by a dual-antenna system are used to produce an interference pattern. The resulting interferogram can be used to filter out surface clutter so as to reveal the signals scattered from the base of the ice sheet. These signals are further processed to produce 3D-images representing basal topography of the ice sheet. In the past three years, the GISMO airborne field campaigns that have been conducted provide a set of useful data for studying geophysical properties of the Greenland ice sheet. While topography information can be obtained using interferometric SAR processing techniques, ice sheet roughness statistics can also be derived by a relatively simple procedure that involves analyzing power levels and the shape of the radar impulse response waveforms. An electromagnetic scattering model describing GISMO impulse responses has previously been proposed and validated. This model suggested that rms-heights and correlation lengths of the upper surface profile can be determined from the peak power and the decay rate of the pulse return waveform, respectively. This presentation will demonstrate a procedure for estimating the roughness of ice surfaces by fitting the GISMO impulse response model to retrieved waveforms from selected GISMO flights. Furthermore, an extension of this procedure to estimate the scattering coefficient of the glacier bed will be addressed as well. Planned future applications involving the classification of glacier bed conditions based on the derived scattering coefficients will also be described.

  4. MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress

    Energy Technology Data Exchange (ETDEWEB)

    Preta, Giulio; Klark, Rainier de; Chakraborti, Shankhamala [Center for Molecular Medicine (CMM), Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm (Sweden); Glas, Rickard, E-mail: rickard.glas@ki.se [Center for Molecular Medicine (CMM), Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm (Sweden)

    2010-08-27

    Research highlights: {yields} Nuclear translocation of TPPII occurs in response to different DNA damage inducers. {yields} Nuclear accumulation of TPPII is linked to ROS and anti-oxidant enzyme levels. {yields} MAPKs control nuclear accumulation of TPPII. {yields} Inhibited nuclear accumulation of TPPII decreases DNA damage-induced {gamma}-H2AX expression. -- Abstract: Reactive oxygen species (ROS) are a continuous hazard in eukaroytic cells by their ability to cause damage to biomolecules, in particular to DNA. Previous data indicated that the cytosolic serine peptidase tripeptidyl-peptidase II (TPPII) translocates into the nucleus of most tumor cell lines in response to {gamma}-irradiation and ROS production; an event that promoted p53 expression as well as caspase-activation. We here observed that nuclear translocation of TPPII was dependent on signaling by MAP kinases, including p38MAPK. Further, this was caused by several types of DNA-damaging drugs, a DNA cross-linker (cisplatinum), an inhibitor of topoisomerase II (etoposide), and to some extent also by nucleoside-analogues (5-fluorouracil, hydroxyurea). In the minority of tumor cell lines where TPPII was not translocated into the nucleus in response to DNA damage we observed reduced intracellular ROS levels, and the expression levels of redox defense systems were increased. Further, treatment with the ROS-inducer {gamma}-hexa-chloro-cyclohexane ({gamma}-HCH, lindane), an inhibitor of GAP junctions, restored nuclear translocation of TPPII in these cell lines upon {gamma}-irradiation. Moreover, blocking nuclear translocation of TPPII in etoposide-treated cells, by using a peptide-derived inhibitor (Z-Gly-Leu-Ala-OH), attenuated expression of {gamma}-H2AX in {gamma}-irradiated melanoma cells. Our results indicated a role for TPPII in MAPK-dependent DNA damage signaling.

  5. Comprehensive mapping of common immunodominant epitopes in the West Nile virus nonstructural protein 1 recognized by avian antibody responses.

    Directory of Open Access Journals (Sweden)

    Encheng Sun

    Full Text Available West Nile virus (WNV is a mosquito-borne flavivirus that primarily infects birds but occasionally infects humans and horses. Certain species of birds, including crows, house sparrows, geese, blue jays and ravens, are considered highly susceptible hosts to WNV. The nonstructural protein 1 (NS1 of WNV can elicit protective immune responses, including NS1-reactive antibodies, during infection of animals. The antigenicity of NS1 suggests that NS1-reactive antibodies could provide a basis for serological diagnostic reagents. To further define serological reagents for diagnostic use, the antigenic sites in NS1 that are targeted by host immune responses need to be identified and the potential diagnostic value of individual antigenic sites also needs to be defined. The present study describes comprehensive mapping of common immunodominant linear B-cell epitopes in the WNV NS1 using avian WNV NS1 antisera. We screened antisera from chickens, ducks and geese immunized with purified NS1 for reactivity against 35 partially overlapping peptides covering the entire WNV NS1. This study identified twelve, nine and six peptide epitopes recognized by chicken, duck and goose antibody responses, respectively. Three epitopes (NS1-3, 14 and 24 were recognized by antibodies elicited by immunization in all three avian species tested. We also found that NS1-3 and 24 were WNV-specific epitopes, whereas the NS1-14 epitope was conserved among the Japanese encephalitis virus (JEV serocomplex viruses based on the reactivity of avian WNV NS1 antisera against polypeptides derived from the NS1 sequences of viruses of the JEV serocomplex. Further analysis showed that the three common polypeptide epitopes were not recognized by antibodies in Avian Influenza Virus (AIV, Newcastle Disease Virus (NDV, Duck Plague Virus (DPV and Goose Parvovirus (GPV antisera. The knowledge and reagents generated in this study have potential applications in differential diagnostic approaches and

  6. Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity training response: the HERITAGE Family Study.

    Science.gov (United States)

    Rice, Treva K; Sarzynski, Mark A; Sung, Yun Ju; Argyropoulos, George; Stütz, Adrian M; Teran-Garcia, Margarita; Rao, D C; Bouchard, Claude; Rankinen, Tuomo

    2012-08-01

    Although regular exercise improves submaximal aerobic capacity, there is large variability in its response to exercise training. While this variation is thought to be partly due to genetic differences, relatively little is known about the causal genes. Submaximal aerobic capacity traits in the current report include the responses of oxygen consumption (ΔVO(2)60), power output (ΔWORK60), and cardiac output (ΔQ60) at 60% of VO2max to a standardized 20-week endurance exercise training program. Genome-wide linkage analysis in 475 HERITAGE Family Study Caucasians identified a locus on chromosome 13q for ΔVO(2)60 (LOD = 3.11). Follow-up fine mapping involved a dense marker panel of over 1,800 single-nucleotide polymorphisms (SNPs) in a 7.9-Mb region (21.1-29.1 Mb from p-terminus). Single-SNP analyses found 14 SNPs moderately associated with both ΔVO(2)60 at P ≤ 0.005 and the correlated traits of ΔWORK60 and ΔQ60 at P < 0.05. Haplotype analyses provided several strong signals (P < 1.0 × 10(-5)) for ΔVO(2)60. Overall, association analyses narrowed the target region and included potential biological candidate genes (MIPEP and SGCG). Consistent with maximal heritability estimates of 23%, up to 20% of the phenotypic variance in ΔVO(2)60 was accounted for by these SNPs. These results implicate candidate genes on chromosome 13q12 for the ability to improve submaximal exercise capacity in response to regular exercise. Submaximal exercise at 60% of maximal capacity is an exercise intensity that falls well within the range recommended in the Physical Activity Guidelines for Americans and thus has potential public health relevance.

  7. Normal spectrum of pulmonary parametric response map to differentiate lung collapsibility: distribution of densitometric classifications in healthy adult volunteers

    International Nuclear Information System (INIS)

    Silva, Mario; Nemec, Stefan F.; Dufresne, Valerie; Occhipinti, Mariaelena; Heidinger, Benedikt H.; Bankier, Alexander A.; Chamberlain, Ryan

    2016-01-01

    Pulmonary parametric response map (PRM) was proposed for quantitative densitometric phenotypization of chronic obstructive pulmonary disease. However, little is known about this technique in healthy subjects. The purpose of this study was to describe the normal spectrum of densitometric classification of pulmonary PRM in a group of healthy adults. 15 healthy volunteers underwent spirometrically monitored chest CT at total lung capacity (TLC) and functional residual capacity (FRC). The paired CT scans were analyzed by PRM for voxel-by-voxel characterization of lung parenchyma according to 4 densitometric classifications: normal lung (TLC ≥ -950 HU, FRC ≥ -856 HU); expiratory low attenuation area (LAA) (TLC ≥ -950 HU, FRC < -856 HU); dual LAA (TLC<-950 HU, FRC < -856 HU); uncharacterized (TLC < -950 HU, FRC ≥ -856 HU). PRM spectrum was 78 % ± 10 % normal lung, 20 % ± 8 % expiratory LAA, and 1 % ± 1 % dual LAA. PRM was similar between genders, there was moderate correlation between dual LAA and spirometrically assessed TLC (R = 0.531; p = 0.042), and between expiratory LAA and Vol Exp/Insp ratio (R = -0.572; p = 0.026). PRM reflects the predominance of normal lung parenchyma in a group of healthy volunteers. However, PRM also confirms the presence of physiological expiratory LAA seemingly related to air trapping and a minimal amount of dual LAA likely reflecting emphysema. (orig.)

  8. Mapping out Map Libraries

    Directory of Open Access Journals (Sweden)

    Ferjan Ormeling

    2008-09-01

    Full Text Available Discussing the requirements for map data quality, map users and their library/archives environment, the paper focuses on the metadata the user would need for a correct and efficient interpretation of the map data. For such a correct interpretation, knowledge of the rules and guidelines according to which the topographers/cartographers work (such as the kind of data categories to be collected, and the degree to which these rules and guidelines were indeed followed are essential. This is not only valid for the old maps stored in our libraries and archives, but perhaps even more so for the new digital files as the format in which we now have to access our geospatial data. As this would be too much to ask from map librarians/curators, some sort of web 2.0 environment is sought where comments about data quality, completeness and up-to-dateness from knowledgeable map users regarding the specific maps or map series studied can be collected and tagged to scanned versions of these maps on the web. In order not to be subject to the same disadvantages as Wikipedia, where the ‘communis opinio’ rather than scholarship, seems to be decisive, some checking by map curators of this tagged map use information would still be needed. Cooperation between map curators and the International Cartographic Association ( ICA map and spatial data use commission to this end is suggested.

  9. Improving mapping for Ebola response through mobilising a local community with self-owned smartphones: Tonkolili District, Sierra Leone, January 2015.

    Directory of Open Access Journals (Sweden)

    Laura M Nic Lochlainn

    Full Text Available During the 2014-16 Ebola virus disease (EVD outbreak, the Magburaka Ebola Management Centre (EMC operated by Médecins Sans Frontières (MSF in Tonkolili District, Sierra Leone, identified that available district maps lacked up-to-date village information to facilitate timely implementation of EVD control strategies. In January 2015, we undertook a survey in chiefdoms within the MSF EMC catchment area to collect mapping and village data. We explore the feasibility and cost to mobilise a local community for this survey, describe validation against existing mapping sources and use of the data to prioritise areas for interventions, and lessons learned.We recruited local people with self-owned Android smartphones installed with open-source survey software (OpenDataKit (ODK and open-source navigation software (OpenStreetMap Automated Navigation Directions (OsmAnd. Surveyors were paired with local motorbike drivers to travel to eligible villages. The collected mapping data were validated by checking for duplication and comparing the village names against a pre-existing village name and location list using a geographic distance and text string-matching algorithm.The survey teams gained sufficient familiarity with the ODK and OsmAnd software within 1-2 hours. Nine chiefdoms in Tonkolili District and three in Bombali District were surveyed within two weeks. Following de-duplication, the surveyors collected data from 891 villages with an estimated 127,021 households. The overall survey cost was €3,395; €3.80 per village surveyed. The MSF GIS team (MSF-OCG created improved maps for the MSF Magburaka EMC team which were used to support surveillance, investigation of suspect EVD cases, hygiene-kit distribution and EVD survivor support. We shared the mapping data with OpenStreetMap, the local Ministry of Health and Sanitation and Sierra Leone District and National Ebola Response Centres.Involving local community and using accessible technology allowed

  10. Improving mapping for Ebola response through mobilising a local community with self-owned smartphones: Tonkolili District, Sierra Leone, January 2015.

    Science.gov (United States)

    Nic Lochlainn, Laura M; Gayton, Ivan; Theocharopoulos, Georgios; Edwards, Robin; Danis, Kostas; Kremer, Ronald; Kleijer, Karline; Tejan, Sumaila M; Sankoh, Mohamed; Jimissa, Augustin; Greig, Jane; Caleo, Grazia

    2018-01-01

    During the 2014-16 Ebola virus disease (EVD) outbreak, the Magburaka Ebola Management Centre (EMC) operated by Médecins Sans Frontières (MSF) in Tonkolili District, Sierra Leone, identified that available district maps lacked up-to-date village information to facilitate timely implementation of EVD control strategies. In January 2015, we undertook a survey in chiefdoms within the MSF EMC catchment area to collect mapping and village data. We explore the feasibility and cost to mobilise a local community for this survey, describe validation against existing mapping sources and use of the data to prioritise areas for interventions, and lessons learned. We recruited local people with self-owned Android smartphones installed with open-source survey software (OpenDataKit (ODK)) and open-source navigation software (OpenStreetMap Automated Navigation Directions (OsmAnd)). Surveyors were paired with local motorbike drivers to travel to eligible villages. The collected mapping data were validated by checking for duplication and comparing the village names against a pre-existing village name and location list using a geographic distance and text string-matching algorithm. The survey teams gained sufficient familiarity with the ODK and OsmAnd software within 1-2 hours. Nine chiefdoms in Tonkolili District and three in Bombali District were surveyed within two weeks. Following de-duplication, the surveyors collected data from 891 villages with an estimated 127,021 households. The overall survey cost was €3,395; €3.80 per village surveyed. The MSF GIS team (MSF-OCG) created improved maps for the MSF Magburaka EMC team which were used to support surveillance, investigation of suspect EVD cases, hygiene-kit distribution and EVD survivor support. We shared the mapping data with OpenStreetMap, the local Ministry of Health and Sanitation and Sierra Leone District and National Ebola Response Centres. Involving local community and using accessible technology allowed rapid

  11. Genome-Wide Association Mapping Reveals Multiple QTLs Governing Tolerance Response for Seedling Stage Chilling Stress in Indica Rice

    Directory of Open Access Journals (Sweden)

    Sharat K. Pradhan

    2017-04-01

    Full Text Available Rice crop is sensitive to cold stress at seedling stage. A panel of population representing 304 shortlisted germplasm lines was studied for seedling stage chilling tolerance in indica rice. Six phenotypic classes were exposed to six low temperature stress regimes under control phenotyping facility to investigate response pattern. A panel of 66 genotypes representing all phenotypic classes was used for ensuring genetic diversity, population structure and association mapping for the trait using 58 simple sequence repeat (SSR and 2 direct trait linked markers. A moderate level of genetic diversity was detected in the panel population for the trait. Deviation of Hardy-Weinberg's expectation was detected in the studied population using Wright's F statistic. The panel showed 30% variation among population and 70% among individuals. The entire population was categorized into three sub-populations through STRUCTURE analysis. This revealed tolerance for the trait had a common primary ancestor for each sub-population with few admix individuals. The panel population showed the presence of many QTLs for cold stress tolerance in the individuals representing like genome-wide expression of the trait. Nineteen SSR markers were significantly associated at chilling stress of 8°C to 4°C for 7–21 days duration. Thus, the primers linked to the seedling stage cold tolerance QTLs namely qCTS9, qCTS-2, qCTS6.1, qSCT2, qSCT11, qSCT1a, qCTS-3.1, qCTS11.1, qCTS12.1, qCTS-1b, and CTB2 need to be pyramided for development of strongly chilling tolerant variety.

  12. Dual-energy computed tomography to assess tumor response to hepatic radiofrequency ablation: potential diagnostic value of virtual noncontrast images and iodine maps.

    Science.gov (United States)

    Lee, Su Hyun; Lee, Jeong Min; Kim, Kyung Won; Klotz, Ernst; Kim, Se Hyung; Lee, Jae Young; Han, Joon Koo; Choi, Byung Ihn

    2011-02-01

    to determine the value of dual-energy (DE) scanning with virtual noncontrast (VNC) images and iodine maps in the evaluation of therapeutic response to radiofrequency ablation (RFA) for hepatic tumors. a total of 75 patients with hepatic tumors and who underwent DE computed tomography (CT) after RFA, were enrolled in this study. Our DE CT protocol included precontrast, arterial, and portal phase scans. VNC images and iodine maps were created from 80 to 140 kVp images during the arterial and portal phases. VNC images were then compared with true, noncontrast (TNC) images, and iodine maps were compared with linearly blended images, both qualitatively and quantitatively. For the former comparison, image quality and acceptability of the VNC images as a replacement for TNC images were both rated. The CT numbers of the hepatic parenchyma, ablation zone, and image noise were measured. For the latter comparison, lesion conspicuity of the ablation zone and the additional benefit of integrating the iodine map into the routine protocol, were assessed. Contrast-to-noise ratios (CNR) of the ablation zone-to-liver and aorta-to-liver as well as the CT number differences between the center and the periphery of the ablation zone were calculated. The image quality of the VNC images was rated as good (mean grading score, 1.88) and the level of acceptance was 90% (68/75). The mean CT numbers of the hepatic parenchyma and ablation zone did not differ significantly between the TNC and the VNC images (P > 0.05). The lesion conspicuity of the ablation zone was rated as excellent or good in 97% of the iodine map (73/75), and the additional benefits of the iodine maps were positively rated as better to the same (mean 1.5). The CNR of the aorta-to-liver parenchyma was significantly higher on the iodine map (P = 0.002), and the CT number differences between the center and the periphery of the ablation zone were significantly lower on the iodine map (P VNC images can be an alternative to TNC

  13. Towards a Poststructuralist Perspective on the Making and the Power of Maps. A Response to Ball and Petsimeris

    Directory of Open Access Journals (Sweden)

    Boris Michel

    2010-08-01

    Full Text Available This paper takes the recent article "Mapping Urban Social Divisions" by BALL and PETSIMERIS, published in FQS, as a starting point for discussing the role of maps for visualizing knowledge and as an object of research in the social sciences. The paper draws on the theoretical approach of "critical cartography" which changed the conception of maps and the practice of mapmaking since the early 1990s. Critical cartography is deeply informed by a poststructuralist critique of knowledge and truth. Maps, no longer conceptualized as graphical images of reality where the only concern is the quality of the data, are powerful actors in the social construction of reality. URN: urn:nbn:de:0114-fqs1003281

  14. Identification of putative QTLs for seedling stage phosphorus starvation response in finger millet (Eleusine coracana L. Gaertn. by association mapping and cross species synteny analysis.

    Directory of Open Access Journals (Sweden)

    M Ramakrishnan

    Full Text Available A germplasm assembly of 128 finger millet genotypes from 18 countries was evaluated for seedling-stage phosphorus (P responses by growing them in P sufficient (Psuf and P deficient (Pdef treatments. Majority of the genotypes showed adaptive responses to low P condition. Based on phenotype behaviour using the best linear unbiased predictors for each trait, genotypes were classified into, P responsive, low P tolerant and P non-responsive types. Based on the overall phenotype performance under Pdef, 10 genotypes were identified as low P tolerants. The low P tolerant genotypes were characterised by increased shoot and root length and increased root hair induction with longer root hairs under Pdef, than under Psuf. Association mapping of P response traits using mixed linear models revealed four quantitative trait loci (QTLs. Two QTLs (qLRDW.1 and qLRDW.2 for low P response affecting root dry weight explained over 10% phenotypic variation. In silico synteny analysis across grass genomes for these QTLs identified putative candidate genes such as Ser-Thr kinase and transcription factors such as WRKY and basic helix-loop-helix (bHLH. The QTLs for response under Psuf were mapped for traits such as shoot dry weight (qHSDW.1 and root length (qHRL.1. Putative associations of these QTLs over the syntenous regions on the grass genomes revealed proximity to cytochrome P450, phosphate transporter and pectin methylesterase inhibitor (PMEI genes. This is the first report of the extent of phenotypic variability for P response in finger millet genotypes during seedling-stage, along with the QTLs and putative candidate genes associated with P starvation tolerance.

  15. Identification of putative QTLs for seedling stage phosphorus starvation response in finger millet (Eleusine coracana L. Gaertn.) by association mapping and cross species synteny analysis.

    Science.gov (United States)

    Ramakrishnan, M; Ceasar, S Antony; Vinod, K K; Duraipandiyan, V; Ajeesh Krishna, T P; Upadhyaya, Hari D; Al-Dhabi, N A; Ignacimuthu, S

    2017-01-01

    A germplasm assembly of 128 finger millet genotypes from 18 countries was evaluated for seedling-stage phosphorus (P) responses by growing them in P sufficient (Psuf) and P deficient (Pdef) treatments. Majority of the genotypes showed adaptive responses to low P condition. Based on phenotype behaviour using the best linear unbiased predictors for each trait, genotypes were classified into, P responsive, low P tolerant and P non-responsive types. Based on the overall phenotype performance under Pdef, 10 genotypes were identified as low P tolerants. The low P tolerant genotypes were characterised by increased shoot and root length and increased root hair induction with longer root hairs under Pdef, than under Psuf. Association mapping of P response traits using mixed linear models revealed four quantitative trait loci (QTLs). Two QTLs (qLRDW.1 and qLRDW.2) for low P response affecting root dry weight explained over 10% phenotypic variation. In silico synteny analysis across grass genomes for these QTLs identified putative candidate genes such as Ser-Thr kinase and transcription factors such as WRKY and basic helix-loop-helix (bHLH). The QTLs for response under Psuf were mapped for traits such as shoot dry weight (qHSDW.1) and root length (qHRL.1). Putative associations of these QTLs over the syntenous regions on the grass genomes revealed proximity to cytochrome P450, phosphate transporter and pectin methylesterase inhibitor (PMEI) genes. This is the first report of the extent of phenotypic variability for P response in finger millet genotypes during seedling-stage, along with the QTLs and putative candidate genes associated with P starvation tolerance.

  16. Mapping the Identity of a Viewed Hand in the Motor System: Evidence from Stimulus-Response Compatibility

    Science.gov (United States)

    Vainio, Lari; Mustonen, Terhi

    2011-01-01

    Brain-imaging research has shown that a viewed acting hand is mapped to the observer's hand representation that corresponds with the identity of the hand. In contrast, behavioral research has suggested that rather than representing a seen hand in relation to one's own manual system, it is represented in relation to the midline of an imaginary…

  17. Analysis of the genetic basis of plant height-related traits in response to ethylene by QTL mapping in maize (Zea mays L.).

    Science.gov (United States)

    Zhang, Weiqiang; Li, Zhi; Fang, Hui; Zhang, Mingcai; Duan, Liusheng

    2018-01-01

    Ethylene (ET) is critical importance in the growth, development, and stress responses of plants. Plant hormonal stress responses have been extensively studied, however, the role of ET in plant growth, especially plant height (PH) remains unclear. Understanding the genetic control for PH in response to ET will provide insights into the regulation of maize development. To clarify the genetic basis of PH-related traits of maize in response to ET, we mapped QTLs for PH, ear height (EH), and internode length above the uppermost ear (ILAU) in two recombinant inbred line (RIL) populations of Zea mays after ET treatment and in an untreated control (CK) group. Sixty QTLs for the three traits were identified. Twenty-two QTLs were simultaneously detected under both ET treatment and untreated control, and five QTLs were detected at two geographic locations under ET treatment only. Individual QTL can be explained 3.87-17.71% of the phenotypic variance. One QTL (q2PH9-1, q1PH9, q1EH9/q1ILAU9-1, q2ILAU9, and q2EH9) for the measured traits (PH, EH, ILAU) was consistent across both populations. Two QTLs (q2PH2-5, q2ILAU2-2, q1PH2-2, and q1ILAU2-2; q1PH8-1, q1EH8-1, q2PH8-1) were identified for up to two traits in both locations and populations under both ET treatment and untreated control. These consistent and stable regions are important QTLs of potential hot spots for PH, ear height (EH), and internode length above the uppermost ear (ILAU) response to ET in maize; therefore, QTL fine-mapping and putative candidate genes validation should enable the cloning of PH, EH, and ILAU related genes to ET response. These results will be valuable for further fine-mapping and quantitative trait nucleotides (QTNs) determination, and elucidate the underlying molecular mechanisms of ET responses in maize.

  18. Analysis of the genetic basis of plant height-related traits in response to ethylene by QTL mapping in maize (Zea mays L..

    Directory of Open Access Journals (Sweden)

    Weiqiang Zhang

    Full Text Available Ethylene (ET is critical importance in the growth, development, and stress responses of plants. Plant hormonal stress responses have been extensively studied, however, the role of ET in plant growth, especially plant height (PH remains unclear. Understanding the genetic control for PH in response to ET will provide insights into the regulation of maize development. To clarify the genetic basis of PH-related traits of maize in response to ET, we mapped QTLs for PH, ear height (EH, and internode length above the uppermost ear (ILAU in two recombinant inbred line (RIL populations of Zea mays after ET treatment and in an untreated control (CK group. Sixty QTLs for the three traits were identified. Twenty-two QTLs were simultaneously detected under both ET treatment and untreated control, and five QTLs were detected at two geographic locations under ET treatment only. Individual QTL can be explained 3.87-17.71% of the phenotypic variance. One QTL (q2PH9-1, q1PH9, q1EH9/q1ILAU9-1, q2ILAU9, and q2EH9 for the measured traits (PH, EH, ILAU was consistent across both populations. Two QTLs (q2PH2-5, q2ILAU2-2, q1PH2-2, and q1ILAU2-2; q1PH8-1, q1EH8-1, q2PH8-1 were identified for up to two traits in both locations and populations under both ET treatment and untreated control. These consistent and stable regions are important QTLs of potential hot spots for PH, ear height (EH, and internode length above the uppermost ear (ILAU response to ET in maize; therefore, QTL fine-mapping and putative candidate genes validation should enable the cloning of PH, EH, and ILAU related genes to ET response. These results will be valuable for further fine-mapping and quantitative trait nucleotides (QTNs determination, and elucidate the underlying molecular mechanisms of ET responses in maize.

  19. Analysis of the genetic basis of plant height-related traits in response to ethylene by QTL mapping in maize (Zea mays L.)

    Science.gov (United States)

    Li, Zhi; Fang, Hui; Zhang, Mingcai; Duan, Liusheng

    2018-01-01

    Ethylene (ET) is critical importance in the growth, development, and stress responses of plants. Plant hormonal stress responses have been extensively studied, however, the role of ET in plant growth, especially plant height (PH) remains unclear. Understanding the genetic control for PH in response to ET will provide insights into the regulation of maize development. To clarify the genetic basis of PH-related traits of maize in response to ET, we mapped QTLs for PH, ear height (EH), and internode length above the uppermost ear (ILAU) in two recombinant inbred line (RIL) populations of Zea mays after ET treatment and in an untreated control (CK) group. Sixty QTLs for the three traits were identified. Twenty-two QTLs were simultaneously detected under both ET treatment and untreated control, and five QTLs were detected at two geographic locations under ET treatment only. Individual QTL can be explained 3.87–17.71% of the phenotypic variance. One QTL (q2PH9-1, q1PH9, q1EH9/q1ILAU9-1, q2ILAU9, and q2EH9) for the measured traits (PH, EH, ILAU) was consistent across both populations. Two QTLs (q2PH2-5, q2ILAU2-2, q1PH2-2, and q1ILAU2-2; q1PH8-1, q1EH8-1, q2PH8-1) were identified for up to two traits in both locations and populations under both ET treatment and untreated control. These consistent and stable regions are important QTLs of potential hot spots for PH, ear height (EH), and internode length above the uppermost ear (ILAU) response to ET in maize; therefore, QTL fine-mapping and putative candidate genes validation should enable the cloning of PH, EH, and ILAU related genes to ET response. These results will be valuable for further fine-mapping and quantitative trait nucleotides (QTNs) determination, and elucidate the underlying molecular mechanisms of ET responses in maize. PMID:29466465

  20. Rapid Response to a Typhoon-Induced Flood with an SAR-Derived Map of Inundated Areas: Case Study and Validation

    Directory of Open Access Journals (Sweden)

    Hsiao-Wei Chung

    2015-09-01

    Full Text Available We report the successful case of a rapid response to a flash flood in I-Lan County of Taiwan with a map of inundated areas derived from COSMO-SkyMed 1 radar satellite imagery within 24 hours. The flood was caused by the intensive precipitation brought by Typhoon Soulik in July 2013. Based on the ensemble forecasts of trajectory, an urgent request of spaceborne SAR imagery was made 24 hours before Typhoon Soulik made landfall. Two COSMO-SkyMed images were successfully acquired when the center of Typhoon Soulik had just crossed the northern part of Taiwan. The standard level-1b product (radiometric-corrected, geometric-calibrated and orthorectified image was generated by using the off-the-shelf SARscape software. Following the same approach used with the Expert Landslide and Shadow Area Delineating System, the regional threshold of each tile image was determined to delineate still water surface and quasi-inundated areas in a fully-automatic manner. The results were overlaid on a digital elevation model, and the same tile was visually compared to an optical image taken by Formosat-2 before this event. With this ancillary information, the inundated areas were accurately and quickly identified. The SAR-derived map of inundated areas was published on a web-based platform powered by Google Earth within 24 hours, with the aim of supporting the decision-making process of disaster prevention and mitigation. A detailed validation was made afterwards by comparing the map with in situ data of the water levels at 17 stations. The results demonstrate the feasibility of rapidly responding to a typhoon-induced flood with a spaceborne SAR-derived map of inundated areas. A standard operating procedure was derived from this work and followed by the Water Hazard Mitigation Center of the Water Resources Agency, Taiwan, in subsequent typhoon seasons, such as Typhoon Trami (August, 2013 and Typhoon Soudelor (August, 2015.

  1. The MAP kinase-activated protein kinase Rck2p regulates cellular responses to cell wall stresses, filamentation and virulence in the human fungal pathogen Candida albicans.

    Science.gov (United States)

    Li, Xichuan; Du, Wei; Zhao, Jingwen; Zhang, Lilin; Zhu, Zhiyan; Jiang, Linghuo

    2010-06-01

    Rck2p is the Hog1p-MAP kinase-activated protein kinase required for the attenuation of protein synthesis in response to an osmotic challenge in Saccharomyces cerevisiae. Rck2p also regulates rapamycin sensitivity in both S. cerevisiae and Candida albicans. In this study, we demonstrate that the deletion of CaRCK2 renders C. albicans cells sensitive to, and CaRck2p translocates from the cytosol to the nucleus in response to, cell wall stresses caused by Congo red, Calcoflor White, elevated heat and zymolyase. However, the kinase activity of CaRck2p is not required for the cellular response to these cell wall stresses. Furthermore, transcripts of cell wall protein-encoding genes CaBGL2, CaHWP1 and CaXOG1 are reduced in C. albicans cells lacking CaRCK2. The deletion of CaRCK2 also reduces the in vitro filamentation of C. albicans and its virulence in a mouse model of systemic candidasis. The kinase activity of CaRck2p is required for the virulence, but not for the in vitro filamentation, in C. albicans. Therefore, Rck2p regulates cellular responses to cell wall stresses, filamentation and virulence in the human fungal pathogen C. albicans.

  2. Global mapping of protein phosphorylation events identifies novel signalling hubs mediating fatty acid starvation responses in Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Pultz, Dennis; Bennetzen, Martin; Rødkær, Steven Vestergaard

    2011-01-01

    Dietary restriction (DR) extends the life span of multiple species, ranging from single-celled organisms like yeast to mammals. This increase in longevity by dietary restriction is coupled to profound beneficial effects on age-related pathology. Despite the number of studies on DR...... and the physiological changes DR induces, only little is known about the genetics and signalling networks, which regulate the DR response. We have recently shown that inhibition of fatty acid synthesis in Saccharomyces cerevisiae induces autophagy mediated by TORC1 signalling and affects life span. In the present study...... in a temporal manner in response to inhibition of fatty acid synthesis by cerulenin. By in silico analysis of these phosphorylation events, we have identified the major downstream regulated processes and signalling networks mediating the cellular response to fatty acid starvation. The analysis further...

  3. Constitutive Activity of the Arabidopsis MAP Kinase 3 Confers Resistance to Pseudomonas syringae and Drives Robust Immune Responses

    KAUST Repository

    Lang, Julien; Genot, Baptiste; Hirt, Heribert; Colcombet, Jean

    2017-01-01

    of a constitutively active (CA) form of the protein led to auto-immune phenotypes. CA-MPK3 plants are dwarf and display defense responses that are characterized by the accumulation of salicylic acid and phytoalexins as well as by the upregulation

  4. Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4

    DEFF Research Database (Denmark)

    Brodersen, P; Petersen, M; Nielsen, Henrik Bjørn

    2006-01-01

    Arabidopsis MPK4 has been implicated in plant defense regulation because mpk4 knockout plants exhibit constitutive activation of salicylic acid (SA)-dependent defenses, but fail to induce jasmonic acid (JA) defense marker genes in response to JA. We show here that mpk4 mutants are also defective...

  5. SNP discovery and development of genetic markers for mapping immune response genes in common carp (Cyprinus carpio)

    Science.gov (United States)

    Single nucleotide polymorphisms (SNPs) in immune response genes have been reported as markers for susceptibility to infectious diseases in human and livestock. A disease caused by cyprinid herpesvirus 3 (CyHV-3) is highly contagious and virulent in common carp (Cyprinus carpio). With the aim to de...

  6. Gene Expression Profiling Soybean Stem Tissue Early Response to Sclerotinia sclerotiorum and In Silico Mapping in Relation to Resistance Markers

    Directory of Open Access Journals (Sweden)

    Bernarda Calla

    2009-07-01

    Full Text Available White mold, caused by (Lib. de Bary, can be a serious disease of crops grown under cool, moist environments. In many plants, such as soybean [ (L. Merr.], complete genetic resistance does not exist. To identify possible genes involved in defense against this pathogen, and to determine possible physiological changes that occur during infection, a microarray screen was conducted using stem tissue to evaluate changes in gene expression between partially resistant and susceptible soybean genotypes at 8 and 14 hours post inoculation. RNA from 15 day-old inoculated plants was labeled and hybridized to soybean cDNA microarrays. ANOVA identified 1270 significant genes from the comparison between time points and 105 genes from the comparison between genotypes. Selected genes were classified into functional categories. The analyses identified changes in cell-wall composition and signaling pathways, as well as suggesting a role for anthocyanin and anthocyanidin synthesis in the defense against . In-silico mapping of both the differentially expressed transcripts and of public markers associated with partial resistance to white mold, provided evidence of several differentially expressed genes being closely positioned to white mold resistance markers, with the two most promising genes encoding a PR-5 and anthocyanidin synthase.

  7. Stream network responses to evapotranspiration in mountain systems: evidence from spatially-distributed network mapping and sapflow measurements

    Science.gov (United States)

    Godsey, S.; Whiting, J. A.; Reinhardt, K.

    2015-12-01

    Stream networks respond to decreased inputs by shrinking from their headwaters and disconnecting along their length. Both the relative stability of the stream network and the degree of disconnection along the network length can strongly affect stream ecology, including fish migration and nutrient spiraling. Previous data suggests that stream network lengths decrease measurably as discharge decreases, and that evapotranspiration may be an important control on stream network persistence. We hypothesized that changes in sapflow timing and magnitude across a gradient from rain-dominated to snow-dominated elevations would be reflected in the stability of the stream network in a steep watershed draining to the Middle Fork Salmon in central Idaho. We expected that the relative timing of water availability across the gradient would drive differences in water delivery to both trees and the stream network. Here we present results that highlight the stability of sapflow timing across the gradient and persistence of the stream network at this site. We discuss geologic controls on network stability and present a conceptual framework identifying characteristics of stable flowheads. We test this framework at four sites in central Idaho with mapped stream networks. We also discuss late summer sapflow patterns across the elevation gradient and their linkages to soil and atmospheric characteristics. Finally, we compare these patterns to those observed at other sites and discuss the role of vegetation in controlling spatiotemporal patterns across the stream network.

  8. Texture coarseness responsive neurons and their mapping in layer 2–3 of the rat barrel cortex in vivo

    Science.gov (United States)

    Garion, Liora; Dubin, Uri; Rubin, Yoav; Khateb, Mohamed; Schiller, Yitzhak; Azouz, Rony; Schiller, Jackie

    2014-01-01

    Texture discrimination is a fundamental function of somatosensory systems, yet the manner by which texture is coded and spatially represented in the barrel cortex are largely unknown. Using in vivo two-photon calcium imaging in the rat barrel cortex during artificial whisking against different surface coarseness or controlled passive whisker vibrations simulating different coarseness, we show that layer 2–3 neurons within barrel boundaries differentially respond to specific texture coarsenesses, while only a minority of neurons responded monotonically with increased or decreased surface coarseness. Neurons with similar preferred texture coarseness were spatially clustered. Multi-contact single unit recordings showed a vertical columnar organization of texture coarseness preference in layer 2–3. These findings indicate that layer 2–3 neurons perform high hierarchical processing of tactile information, with surface coarseness embodied by distinct neuronal subpopulations that are spatially mapped onto the barrel cortex. DOI: http://dx.doi.org/10.7554/eLife.03405.001 PMID:25233151

  9. Polarized Raman anisotropic response of collagen in tendon: towards 3D orientation mapping of collagen in tissues.

    Directory of Open Access Journals (Sweden)

    Leonardo Galvis

    Full Text Available In this study, polarized Raman spectroscopy (PRS was used to characterize the anisotropic response of the amide I band of collagen as a basis for evaluating three-dimensional collagen fibril orientation in tissues. Firstly, the response was investigated theoretically by applying classical Raman theory to collagen-like peptide crystal structures. The theoretical methodology was then tested experimentally, by measuring amide I intensity anisotropy in rat tail as a function of the orientation of the incident laser polarization. For the theoretical study, several collagen-like triple-helical peptide crystal structures obtained from the Protein Data Bank were rotated "in plane" and "out of plane" to evaluate the role of molecular orientation on the intensity of the amide I band. Collagen-like peptides exhibit a sinusoidal anisotropic response when rotated "in plane" with respect to the polarized incident laser. Maximal intensity was obtained when the polarization of the incident light is perpendicular to the molecule and minimal when parallel. In the case of "out of plane" rotation of the molecular structure a decreased anisotropic response was observed, becoming completely isotropic when the structure was perpendicular to the plane of observation. The theoretical Raman response of collagen was compared to that of alpha helical protein fragments. In contrast to collagen, alpha helices have a maximal signal when incident light is parallel to the molecule and minimal when perpendicular. For out-of-plane molecular orientations alpha-helix structures display a decreased average intensity. Results obtained from experiments on rat tail tendon are in excellent agreement with the theoretical predictions, thus demonstrating the high potential of PRS for experimental evaluation of the three-dimensional orientation of collagen fibers in biological tissues.

  10. Constitutive Activity of the Arabidopsis MAP Kinase 3 Confers Resistance to Pseudomonas syringae and Drives Robust Immune Responses

    KAUST Repository

    Lang, Julien

    2017-08-02

    Mitogen Activated Protein Kinases (MAPKs) are known to be important mediators of plant responses to biotic and abiotic stresses. In a recent report, we enlarged the understanding of the Arabidopsis thaliana MPK3 functions showing that the expression of a constitutively active (CA) form of the protein led to auto-immune phenotypes. CA-MPK3 plants are dwarf and display defense responses that are characterized by the accumulation of salicylic acid and phytoalexins as well as by the upregulation of several defense genes. Consistently with these data, we present here results demonstrating that, compared to wild type controls, CA-MPK3 plants are more resistant to the hemibiotrophic pathogen Pseudomonas syringae DC3000. Based on our previous work, we also discuss the mechanisms of robust plant immunity controlled by sustained MPK3 activity, focusing especially on the roles of disease resistance proteins.

  11. Generalized Smooth Transition Map Between Tent and Logistic Maps

    Science.gov (United States)

    Sayed, Wafaa S.; Fahmy, Hossam A. H.; Rezk, Ahmed A.; Radwan, Ahmed G.

    There is a continuous demand on novel chaotic generators to be employed in various modeling and pseudo-random number generation applications. This paper proposes a new chaotic map which is a general form for one-dimensional discrete-time maps employing the power function with the tent and logistic maps as special cases. The proposed map uses extra parameters to provide responses that fit multiple applications for which conventional maps were not enough. The proposed generalization covers also maps whose iterative relations are not based on polynomials, i.e. with fractional powers. We introduce a framework for analyzing the proposed map mathematically and predicting its behavior for various combinations of its parameters. In addition, we present and explain the transition map which results in intermediate responses as the parameters vary from their values corresponding to tent map to those corresponding to logistic map case. We study the properties of the proposed map including graph of the map equation, general bifurcation diagram and its key-points, output sequences, and maximum Lyapunov exponent. We present further explorations such as effects of scaling, system response with respect to the new parameters, and operating ranges other than transition region. Finally, a stream cipher system based on the generalized transition map validates its utility for image encryption applications. The system allows the construction of more efficient encryption keys which enhances its sensitivity and other cryptographic properties.

  12. Constitutively active Arabidopsis MAP Kinase 3 triggers defense responses involving salicylic acid and SUMM2 resistance protein

    KAUST Repository

    Genot, Baptiste

    2017-04-12

    Mitogen-activated protein kinases (MAPKs) are important regulators of plant immunity. Most of the knowledge about the function of these pathways is derived from loss-of-function approaches. Using a gain-of-function approach, we investigated the responses controlled by a constitutively active (CA) MPK3 in Arabidopsis thaliana. CA-MPK3 plants are dwarfed and display a massive de-repression of defense genes associated with spontaneous cell death as well as accumulation of reactive oxygen species (ROS), phytoalexins and the stress-related hormones ethylene and salicylic acid (SA). Remarkably CA-MPK3/sid2 and CA-MPK3/ein2-50 lines which are impaired in SA synthesis and ethylene signaling, respectively, retain most of the CA-MPK3-associated phenotypes, indicating that constitutive activity of MPK3 can bypass SA and ethylene signaling to activate defense responses. A comparative analysis of the molecular phenotypes of CA-MPK3 and mpk4 autoimmunity suggested convergence between the MPK3 and MPK4-guarding modules. In support of this model, CA-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4, resulted in a partial reversion of the CA-MPK3 phenotypes. Overall, our data unravel a novel mechanism by which the MAPK signaling network contributes to a robust defense response system.

  13. Mapping the neural substrates involved in maternal responsiveness and lamb olfactory memory in parturient ewes using Fos imaging.

    Science.gov (United States)

    Keller, Matthieu; Meurisse, Maryse; Lévy, Frédéric

    2004-12-01

    In sheep, recognition of the familiar lamb by the mother depends on the learning of its olfactory signature after parturition. The authors quantified Fos changes in order to identify brain regions activated during lamb odor memory formation. Brain activation was compared with those measured in anosmic ewes displaying maternal behavior but not individual lamb recognition. In intact ewes, parturition induced significant increase in Fos expression in olfactory cortical regions and in cortical amygdala, whereas in anosmic mothers, Fos expression was very low. In contrast, no difference was observed between intact and anosmic ewes in hypothalamic areas and medial amygdala, suggesting a differentiation between the neural network controlling maternal responsiveness and that involved in olfactory lamb memory.

  14. The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages

    Directory of Open Access Journals (Sweden)

    Debprasad Chattopadhyay

    2017-05-01

    Full Text Available Tuberculosis (TB remains one of the greatest health concerns worldwide, which has hindered socioeconomic development in certain parts of the world for many centuries. Although current TB therapy, “Directly Observed Treatment Short-course,” is effective, it is associated with unwanted side effects and the risk for the generation of drug-resistant organisms. The majority of infected individuals successfully confine the mycobacterial organisms and remain asymptotic unless immune responses are perturbed. Thus, host immunity can protect against TB and immunomodulation is therefore an attractive therapeutic option. Previous studies have shown that TNF-α and Nitric Oxide (NO in conjunction with IFN-γ-producing T helper 1 (Th1 cells play critical roles in host protection against TB. Here, we show that bergenin, a phytochemical isolated from tender leaves of Shorea robusta, activates the MAP kinase and ERK pathways and induces TNF-α, NO and IL-12 production in infected macrophages. We further show that bergenin induces Th1 immune responses and potently inhibits bacillary growth in a murine model of Mycobacterium tuberculosis infection. These findings identify bergenin as a potential adjunct to TB therapy.

  15. Mapping knowledge investments in the aftermath of Hurricane Katrina: a new approach for assessing regulatory agency responses to environmental disaster

    International Nuclear Information System (INIS)

    Frickel, Scott; Campanella, Richard; Vincent, M. Bess

    2009-01-01

    In the aftermath of large-scale disasters, the public's dependency on federal and state agencies for information about public safety and environmental risk is acute. While formal rules and procedures are in place to guide policy decisions in environmental risk assessment of spatially concentrated hazards such as regulated waste sites or vacant city lots, standard procedures for risk assessment seem potentially less well-suited for urban-scale disaster zones where environmental hazards may be widely dispersed and widely varying. In this paper we offer a new approach for the social assessment of regulatory science in response to large-scale disaster, illustrating our methodology through a socio-spatial analysis of the U.S. Environmental Protection Agency's (EPA) hazard assessment in New Orleans, Louisiana, following Hurricane Katrina in 2005. We find that the agency's commitment of epistemic resources or 'knowledge investments' varied considerably across the flood-impacted portion of the city, concentrating in poorer and disproportionately African American neighborhoods previously known to be heavily contaminated. We address some of the study's social and policy implications, noting the multidimensionality and interactive nature of knowledge investments and the prospects for deepening and extending this approach through comparative research

  16. Mapping of the brain hemodynamic responses to sensorimotor stimulation in a rodent model: A BOLD fMRI study.

    Directory of Open Access Journals (Sweden)

    Salem Boussida

    Full Text Available Blood Oxygenation Level Dependent functional MRI (BOLD fMRI during electrical paw stimulation has been widely used in studies aimed at the understanding of the somatosensory network in rats. However, despite the well-established anatomical connections between cortical and subcortical structures of the sensorimotor system, most of these functional studies have been concentrated on the cortical effects of sensory electrical stimulation. BOLD fMRI study of the integration of a sensorimotor input across the sensorimotor network requires an appropriate methodology to elicit functional activation in cortical and subcortical areas owing to the regional differences in both neuronal and vascular architectures between these brain regions. Here, using a combination of low level anesthesia, long pulse duration of the electrical stimulation along with improved spatial and temporal signal to noise ratios, we provide a functional description of the main cortical and subcortical structures of the sensorimotor rat brain. With this calibrated fMRI protocol, unilateral non-noxious sensorimotor electrical hindpaw stimulation resulted in robust positive activations in the contralateral sensorimotor cortex and bilaterally in the sensorimotor thalamus nuclei, whereas negative activations were observed bilaterally in the dorsolateral caudate-putamen. These results demonstrate that, once the experimental setup allowing necessary spatial and temporal signal to noise ratios is reached, hemodynamic changes related to neuronal activity, as preserved by the combination of a soft anesthesia with a soft muscle relaxation, can be measured within the sensorimotor network. Moreover, the observed responses suggest that increasing pulse duration of the electrical stimulus adds a proprioceptive component to the sensory input that activates sensorimotor network in the brain, and that these activation patterns are similar to those induced by digits paw's movements. These findings may

  17. Mapping the Structural Determinants Responsible for Enhanced T Cell Activation to the Immunogenic Adeno-Associated Virus Capsid from Isolate Rhesus 32.33

    Science.gov (United States)

    Mays, Lauren E.; Wang, Lili; Tenney, Rebeca; Bell, Peter; Nam, Hyun-Joo; Lin, Jianping; Gurda, Brittney; Van Vliet, Kim; Mikals, Kyle; Agbandje-McKenna, Mavis

    2013-01-01

    Avoiding activation of immunity to vector-encoded proteins is critical to the safe and effective use of adeno-associated viral (AAV) vectors for gene therapy. While commonly used serotypes, such as AAV serotypes 1, 2, 7, 8, and 9, are often associated with minimal and/or dysfunctional CD8+ T cell responses in mice, the threshold for immune activation appears to be lower in higher-order species. We have modeled this discrepancy within the mouse by identifying two capsid variants with differential immune activation profiles: AAV serotype 8 (AAV8) and a hybrid between natural rhesus isolates AAVrh32 and AAVrh33 (AAVrh32.33). Here, we aimed to characterize the structural determinants of the AAVrh32.33 capsid that augment cellular immunity to vector-encoded proteins or those of AAV8 that may induce tolerance. We hypothesized that the structural domain responsible for differential immune activation could be mapped to surface-exposed regions of the capsid, such as hypervariable regions (HVRs) I to IX of VP3. To test this, a series of hybrid AAV capsids was constructed by swapping domains between AAV8 and AAVrh32.33. By comparing their ability to generate transgene-specific T cells in vivo versus the stability of transgene expression in the muscle, we confirmed that the functional domain lies within the VP3 portion of the capsid. Our studies were able to exclude the regions of VP3 which are not sufficient for augmenting the cellular immune response, notably, HVRs I, II, and V. We have also identified HVR IV as a region of interest in conferring the efficiency and stability of muscle transduction to AAVrh32.33. PMID:23720715

  18. Topographic mapping

    Science.gov (United States)

    ,

    2008-01-01

    The U.S. Geological Survey (USGS) produced its first topographic map in 1879, the same year it was established. Today, more than 100 years and millions of map copies later, topographic mapping is still a central activity for the USGS. The topographic map remains an indispensable tool for government, science, industry, and leisure. Much has changed since early topographers traveled the unsettled West and carefully plotted the first USGS maps by hand. Advances in survey techniques, instrumentation, and design and printing technologies, as well as the use of aerial photography and satellite data, have dramatically improved mapping coverage, accuracy, and efficiency. Yet cartography, the art and science of mapping, may never before have undergone change more profound than today.

  19. Single-edition quadrangle maps

    Science.gov (United States)

    ,

    1998-01-01

    In August 1993, the U.S. Geological Survey's (USGS) National Mapping Division and the U.S. Department of Agriculture's Forest Service signed an Interagency Agreement to begin a single-edition joint mapping program. This agreement established the coordination for producing and maintaining single-edition primary series topographic maps for quadrangles containing National Forest System lands. The joint mapping program saves money by eliminating duplication of effort by the agencies and results in a more frequent revision cycle for quadrangles containing national forests. Maps are revised on the basis of jointly developed standards and contain normal features mapped by the USGS, as well as additional features required for efficient management of National Forest System lands. Single-edition maps look slightly different but meet the content, accuracy, and quality criteria of other USGS products. The Forest Service is responsible for the land management of more than 191 million acres of land throughout the continental United States, Alaska, and Puerto Rico, including 155 national forests and 20 national grasslands. These areas make up the National Forest System lands and comprise more than 10,600 of the 56,000 primary series 7.5-minute quadrangle maps (15-minute in Alaska) covering the United States. The Forest Service has assumed responsibility for maintaining these maps, and the USGS remains responsible for printing and distributing them. Before the agreement, both agencies published similar maps of the same areas. The maps were used for different purposes, but had comparable types of features that were revised at different times. Now, the two products have been combined into one so that the revision cycle is stabilized and only one agency revises the maps, thus increasing the number of current maps available for National Forest System lands. This agreement has improved service to the public by requiring that the agencies share the same maps and that the maps meet a

  20. FvBck1, a Component of Cell Wall Integrity MAP Kinase Pathway, is Required for Virulence and Oxidative Stress Response in Sugarcane Pokkah Boeng Pathogen

    Directory of Open Access Journals (Sweden)

    Chengkang eZhang

    2015-10-01

    Full Text Available Fusarium verticillioides (formerly F. moniliforme is suggested as one of the causal agents of Pokkah Boeng, a serious disease of sugarcane worldwide. Currently, detailed molecular and physiological mechanism of pathogenesis is unknown. In this study, we focused on cell wall integrity MAPK pathway as one of the potential signaling mechanisms associated with Pokkah Boeng pathogenesis. We identified FvBCK1 gene that encodes a MAP kinase kinase kinase homolog and determined that it is not only required for growth, micro- and macro-conidia production, and cell wall integrity but also for response to osmotic and oxidative stresses. The deletion of FvBCK1 caused a significant reduction in virulence and FB1 production, a carcinogenic mycotoxin produced by the fungus. Moreover, we found the expression levels of three genes, which are known to be involved in superoxide scavenging, were down regulated in the mutant. We hypothesized that the loss of superoxide scavenging capacity was one of the reasons for reduced virulence, but overexpression of catalase or peroxidase gene failed to restore the virulence defect in the deletion mutant. When we introduced Magnaporthe oryzae MCK1 into the FvBck1 deletion mutant, while certain phenotypes were restored, the complemented strain failed to gain full virulence. In summary, FvBck1 plays a diverse role in F. verticillioides, and detailed investigation of downstream signaling pathways will lead to a better understanding of how this MAPK pathway regulates Pokkah Boeng on sugarcane.

  1. How entorhinal grid cells may learn multiple spatial scales from a dorsoventral gradient of cell response rates in a self-organizing map.

    Directory of Open Access Journals (Sweden)

    Stephen Grossberg

    Full Text Available Place cells in the hippocampus of higher mammals are critical for spatial navigation. Recent modeling clarifies how this may be achieved by how grid cells in the medial entorhinal cortex (MEC input to place cells. Grid cells exhibit hexagonal grid firing patterns across space in multiple spatial scales along the MEC dorsoventral axis. Signals from grid cells of multiple scales combine adaptively to activate place cells that represent much larger spaces than grid cells. But how do grid cells learn to fire at multiple positions that form a hexagonal grid, and with spatial scales that increase along the dorsoventral axis? In vitro recordings of medial entorhinal layer II stellate cells have revealed subthreshold membrane potential oscillations (MPOs whose temporal periods, and time constants of excitatory postsynaptic potentials (EPSPs, both increase along this axis. Slower (faster subthreshold MPOs and slower (faster EPSPs correlate with larger (smaller grid spacings and field widths. A self-organizing map neural model explains how the anatomical gradient of grid spatial scales can be learned by cells that respond more slowly along the gradient to their inputs from stripe cells of multiple scales, which perform linear velocity path integration. The model cells also exhibit MPO frequencies that covary with their response rates. The gradient in intrinsic rhythmicity is thus not compelling evidence for oscillatory interference as a mechanism of grid cell firing. A response rate gradient combined with input stripe cells that have normalized receptive fields can reproduce all known spatial and temporal properties of grid cells along the MEC dorsoventral axis. This spatial gradient mechanism is homologous to a gradient mechanism for temporal learning in the lateral entorhinal cortex and its hippocampal projections. Spatial and temporal representations may hereby arise from homologous mechanisms, thereby embodying a mechanistic "neural relativity" that

  2. Participatory Maps

    DEFF Research Database (Denmark)

    Salovaara-Moring, Inka

    2016-01-01

    practice. In particular, mapping environmental damage, endangered species, and human-made disasters has become one focal point for environmental knowledge production. This type of digital map has been highlighted as a processual turn in critical cartography, whereas in related computational journalism...... of a geo-visualization within information mapping that enhances embodiment in the experience of the information. InfoAmazonia is defined as a digitally created map-space within which journalistic practice can be seen as dynamic, performative interactions between journalists, ecosystems, space, and species...

  3. Concept Mapping

    Science.gov (United States)

    Technology & Learning, 2005

    2005-01-01

    Concept maps are graphical ways of working with ideas and presenting information. They reveal patterns and relationships and help students to clarify their thinking, and to process, organize and prioritize. Displaying information visually--in concept maps, word webs, or diagrams--stimulates creativity. Being able to think logically teaches…

  4. Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion

    Directory of Open Access Journals (Sweden)

    Mortiz eArmbruster

    2014-09-01

    Full Text Available Astrocytic uptake of glutamate shapes extracellular neurotransmitter dynamics, receptor activation, and synaptogenesis. During development, glutamate transport becomes more robust. How neonatal brain insult affects the functional maturation of glutamate transport remains unanswered. Neonatal brain insult can lead to developmental delays, cognitive losses, and epilepsy; the disruption of glutamate transport is known to cause changes in synaptogenesis, receptor activation, and seizure. Using the neonatal freeze-lesion (FL model, we have investigated how insult affects the maturation of astrocytic glutamate transport. As lesioning occurs on the day of birth, a time when astrocytes are still functionally immature, this model is ideal for identifying changes in astrocyte maturation following insult. Reactive astrocytosis, astrocyte proliferation, and in vitro hyperexcitability are known to occur in this model. To probe astrocyte glutamate transport with better spatial precision we have developed a novel technique, Laser Scanning Astrocyte Mapping (LSAM, which combines glutamate transport current (TC recording from astrocytes with laser scanning glutamate photolysis. LSAM allows us to identify the area from which a single astrocyte can transport glutamate and to quantify spatial heterogeneity in the rate of glutamate clearance kinetics within that domain. Using LSAM, we report that cortical astrocytes have an increased glutamate-responsive area following FL and that TCs have faster decay times in distal, as compared to proximal processes. Furthermore, the developmental shift from GLAST- to GLT-1-dominated clearance is disrupted following FL. These findings introduce a novel method to probe astrocyte glutamate uptake and show that neonatal cortical FL disrupts the functional maturation of cortical astrocytes.

  5. Response

    Science.gov (United States)

    Higgins, Chris

    2012-01-01

    This article presents the author's response to the reviews of his book, "The Good Life of Teaching: An Ethics of Professional Practice." He begins by highlighting some of the main concerns of his book. He then offers a brief response, doing his best to address the main criticisms of his argument and noting where the four reviewers (Charlene…

  6. Probabilistic mapping of descriptive health status responses onto health state utilities using Bayesian networks: an empirical analysis converting SF-12 into EQ-5D utility index in a national US sample.

    Science.gov (United States)

    Le, Quang A; Doctor, Jason N

    2011-05-01

    As quality-adjusted life years have become the standard metric in health economic evaluations, mapping health-profile or disease-specific measures onto preference-based measures to obtain quality-adjusted life years has become a solution when health utilities are not directly available. However, current mapping methods are limited due to their predictive validity, reliability, and/or other methodological issues. We employ probability theory together with a graphical model, called a Bayesian network, to convert health-profile measures into preference-based measures and to compare the results to those estimated with current mapping methods. A sample of 19,678 adults who completed both the 12-item Short Form Health Survey (SF-12v2) and EuroQoL 5D (EQ-5D) questionnaires from the 2003 Medical Expenditure Panel Survey was split into training and validation sets. Bayesian networks were constructed to explore the probabilistic relationships between each EQ-5D domain and 12 items of the SF-12v2. The EQ-5D utility scores were estimated on the basis of the predicted probability of each response level of the 5 EQ-5D domains obtained from the Bayesian inference process using the following methods: Monte Carlo simulation, expected utility, and most-likely probability. Results were then compared with current mapping methods including multinomial logistic regression, ordinary least squares, and censored least absolute deviations. The Bayesian networks consistently outperformed other mapping models in the overall sample (mean absolute error=0.077, mean square error=0.013, and R overall=0.802), in different age groups, number of chronic conditions, and ranges of the EQ-5D index. Bayesian networks provide a new robust and natural approach to map health status responses into health utility measures for health economic evaluations.

  7. Mapping racism.

    Science.gov (United States)

    Moss, Donald B

    2006-01-01

    The author uses the metaphor of mapping to illuminate a structural feature of racist thought, locating the degraded object along vertical and horizontal axes. These axes establish coordinates of hierarchy and of distance. With the coordinates in place, racist thought begins to seem grounded in natural processes. The other's identity becomes consolidated, and parochialism results. The use of this kind of mapping is illustrated via two patient vignettes. The author presents Freud's (1905, 1927) views in relation to such a "mapping" process, as well as Adorno's (1951) and Baldwin's (1965). Finally, the author conceptualizes the crucial status of primitivity in the workings of racist thought.

  8. BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone

    Directory of Open Access Journals (Sweden)

    Kelsey Moore

    2016-11-01

    Full Text Available Blood oxygen level dependent (BOLD imaging in awake mice was used to identify differences in brain activity between wild-type, and Mu (µ opioid receptor knock-outs (MuKO in response to oxycodone (OXY. Using a segmented, annotated MRI mouse atlas and computational analysis, patterns of integrated positive and negative BOLD activity were identified across 122 brain areas. The pattern of positive BOLD showed enhanced activation across the brain in WT mice within 15 min of intraperitoneal administration of 2.5 mg of OXY. BOLD activation was detected in 72 regions out of 122, and was most prominent in areas of high µ opioid receptor density (thalamus, ventral tegmental area, substantia nigra, caudate putamen, basal amygdala and hypothalamus, and focus on pain circuits indicated strong activation in major pain processing centers (central amygdala, solitary tract, parabrachial area, insular cortex, gigantocellularis area, ventral thalamus primary sensory cortex and prelimbic cortex. Importantly, the OXY-induced positive BOLD was eliminated in MuKO mice in most regions, with few exceptions (some cerebellar nuclei, CA3 of the hippocampus, medial amygdala and preoptic areas. This result indicates that most effects of OXY on positive BOLD are mediated by the µ opioid receptor (on-target effects. OXY also caused an increase in negative BOLD in WT mice in few regions (16 out of 122 and, unlike the positive BOLD response the negative BOLD was only partially eliminated in the MuKO mice (cerebellum, and in some case intensified (hippocampus. Negative BOLD analysis therefore shows activation and deactivation events in the absence of the µ receptor for some areas where receptor expression is normally extremely low or absent (off-target effects. Together, our approach permits establishing opioid-induced BOLD activation maps in awake mice. In addition, comparison of WT and MuKO mutant mice reveals both on-target and off-target activation events, and set an OXY

  9. Genetic Mapping

    Science.gov (United States)

    ... greatly advanced genetics research. The improved quality of genetic data has reduced the time required to identify a ... cases, a matter of months or even weeks. Genetic mapping data generated by the HGP's laboratories is freely accessible ...

  10. Mapping the northern plains of Mars: origins, evolution and response to climate change - a new overview of recent ice-related landforms in Utopia Planitia

    Science.gov (United States)

    Séjourné, A.; Costard, F.; Losiak, A.; Swirad, Z. M.; Balme, M. R.; Conway, S. J.; Gallagher, C.; Hauber, E.; Johnsson, A. E.; Kereszturi, A.; Orgel, C.; Platz, T.; Ramsdale, J. D.; Reiss, D.; Skinner, J. A., Jr.; Van Gasselt, S.

    2015-10-01

    An International Space Science Institute (ISSI) team project has been convened to study ice-related landforms in targeted areas in the northern plain of Mars: Acidalia Planitia, Arcadia Planitia, and Utopia Planitia. Here, over western Utopia Planitia, ice-related landforms were identified and recorded in a sub-grid square. The end result of the mapping is a "raster" showing the distribution of thevarious different types of landforms across the whole strip providing a digital geomorph ological map (Fig. 1).

  11. Improving mapping for Ebola response through mobilising a local community with self-owned smartphones: Tonkolili District, Sierra Leone, January 2015

    OpenAIRE

    Nic Lochlainn, Laura M.; Gayton, Ivan; Theocharopoulos, Georgios; Edwards, Robin; Danis, Kostas; Kremer, Ronald; Kleijer, Karline; Tejan, Sumaila M.; Sankoh, Mohamed; Jimissa, Augustin; Greig, Jane; Caleo, Grazia

    2018-01-01

    Background During the 2014–16 Ebola virus disease (EVD) outbreak, the Magburaka Ebola Management Centre (EMC) operated by Médecins Sans Frontières (MSF) in Tonkolili District, Sierra Leone, identified that available district maps lacked up-to-date village information to facilitate timely implementation of EVD control strategies. In January 2015, we undertook a survey in chiefdoms within the MSF EMC catchment area to collect mapping and village data. We explore the feasibility and cost to mobi...

  12. Projective mapping

    DEFF Research Database (Denmark)

    Dehlholm, Christian; Brockhoff, Per B.; Bredie, Wender Laurentius Petrus

    2012-01-01

    by the practical testing environment. As a result of the changes, a reasonable assumption would be to question the consequences caused by the variations in method procedures. Here, the aim is to highlight the proven or hypothetic consequences of variations of Projective Mapping. Presented variations will include...... instructions and influence heavily the product placements and the descriptive vocabulary (Dehlholm et.al., 2012b). The type of assessors performing the method influences results with an extra aspect in Projective Mapping compared to more analytical tests, as the given spontaneous perceptions are much dependent......Projective Mapping (Risvik et.al., 1994) and its Napping (Pagès, 2003) variations have become increasingly popular in the sensory field for rapid collection of spontaneous product perceptions. It has been applied in variations which sometimes are caused by the purpose of the analysis and sometimes...

  13. Affective Maps

    DEFF Research Database (Denmark)

    Salovaara-Moring, Inka

    . In particular, mapping environmental damage, endangered species, and human made disasters has become one of the focal point of affective knowledge production. These ‘more-than-humangeographies’ practices include notions of species, space and territory, and movement towards a new political ecology. This type...... of digital cartographies has been highlighted as the ‘processual turn’ in critical cartography, whereas in related computational journalism it can be seen as an interactive and iterative process of mapping complex and fragile ecological developments. This paper looks at computer-assisted cartography as part...

  14. Improving mapping for Ebola response through mobilising a local community with self-owned smartphones: Tonkolili District, Sierra Leone, January 2015.

    NARCIS (Netherlands)

    Nic Lochlainn, Laura M; Gayton, Ivan; Theocharopoulos, Georgios; Edwards, Robin; Danis, Kostas; Kremer, Ronald; Kleijer, Karline; Tejan, Sumaila M; Sankoh, Mohamed; Jimissa, Augustin; Greig, Jane; Caleo, Grazia

    2018-01-01

    During the 2014-16 Ebola virus disease (EVD) outbreak, the Magburaka Ebola Management Centre (EMC) operated by Médecins Sans Frontières (MSF) in Tonkolili District, Sierra Leone, identified that available district maps lacked up-to-date village information to facilitate timely implementation of EVD

  15. Energetic map

    International Nuclear Information System (INIS)

    2012-01-01

    This report explains the energetic map of Uruguay as well as the different systems that delimits political frontiers in the region. The electrical system importance is due to the electricity, oil and derived , natural gas, potential study, biofuels, wind and solar energy

  16. Necklace maps

    NARCIS (Netherlands)

    Speckmann, B.; Verbeek, K.A.B.

    2010-01-01

    Statistical data associated with geographic regions is nowadays globally available in large amounts and hence automated methods to visually display these data are in high demand. There are several well-established thematic map types for quantitative data on the ratio-scale associated with regions:

  17. Participatory maps

    DEFF Research Database (Denmark)

    Salovaara-Moring, Inka

    towards a new political ecology. This type of digital cartographies has been highlighted as the ‘processual turn’ in critical cartography, whereas in related computational journalism it can be seen as an interactive and iterative process of mapping complex and fragile ecological developments. This paper...

  18. Statistical methods in physical mapping

    International Nuclear Information System (INIS)

    Nelson, D.O.

    1995-05-01

    One of the great success stories of modern molecular genetics has been the ability of biologists to isolate and characterize the genes responsible for serious inherited diseases like fragile X syndrome, cystic fibrosis and myotonic muscular dystrophy. This dissertation concentrates on constructing high-resolution physical maps. It demonstrates how probabilistic modeling and statistical analysis can aid molecular geneticists in the tasks of planning, execution, and evaluation of physical maps of chromosomes and large chromosomal regions. The dissertation is divided into six chapters. Chapter 1 provides an introduction to the field of physical mapping, describing the role of physical mapping in gene isolation and ill past efforts at mapping chromosomal regions. The next two chapters review and extend known results on predicting progress in large mapping projects. Such predictions help project planners decide between various approaches and tactics for mapping large regions of the human genome. Chapter 2 shows how probability models have been used in the past to predict progress in mapping projects. Chapter 3 presents new results, based on stationary point process theory, for progress measures for mapping projects based on directed mapping strategies. Chapter 4 describes in detail the construction of all initial high-resolution physical map for human chromosome 19. This chapter introduces the probability and statistical models involved in map construction in the context of a large, ongoing physical mapping project. Chapter 5 concentrates on one such model, the trinomial model. This chapter contains new results on the large-sample behavior of this model, including distributional results, asymptotic moments, and detection error rates. In addition, it contains an optimality result concerning experimental procedures based on the trinomial model. The last chapter explores unsolved problems and describes future work

  19. Statistical methods in physical mapping

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, David O. [Univ. of California, Berkeley, CA (United States)

    1995-05-01

    One of the great success stories of modern molecular genetics has been the ability of biologists to isolate and characterize the genes responsible for serious inherited diseases like fragile X syndrome, cystic fibrosis and myotonic muscular dystrophy. This dissertation concentrates on constructing high-resolution physical maps. It demonstrates how probabilistic modeling and statistical analysis can aid molecular geneticists in the tasks of planning, execution, and evaluation of physical maps of chromosomes and large chromosomal regions. The dissertation is divided into six chapters. Chapter 1 provides an introduction to the field of physical mapping, describing the role of physical mapping in gene isolation and ill past efforts at mapping chromosomal regions. The next two chapters review and extend known results on predicting progress in large mapping projects. Such predictions help project planners decide between various approaches and tactics for mapping large regions of the human genome. Chapter 2 shows how probability models have been used in the past to predict progress in mapping projects. Chapter 3 presents new results, based on stationary point process theory, for progress measures for mapping projects based on directed mapping strategies. Chapter 4 describes in detail the construction of all initial high-resolution physical map for human chromosome 19. This chapter introduces the probability and statistical models involved in map construction in the context of a large, ongoing physical mapping project. Chapter 5 concentrates on one such model, the trinomial model. This chapter contains new results on the large-sample behavior of this model, including distributional results, asymptotic moments, and detection error rates. In addition, it contains an optimality result concerning experimental procedures based on the trinomial model. The last chapter explores unsolved problems and describes future work.

  20. ASTROMETRIC REVERBERATION MAPPING

    International Nuclear Information System (INIS)

    Shen Yue

    2012-01-01

    Spatially extended emission regions of active galactic nuclei respond to continuum variations, if such emission regions are powered by energy reprocessing of the continuum. The response from different parts of the reverberating region arrives at different times lagging behind the continuum variation. The lags can be used to map the geometry and kinematics of the emission region (i.e., reverberation mapping, RM). If the extended emission region is not spherically symmetric in configuration and velocity space, reverberation may produce astrometric offsets in the emission region photocenter as a function of time delay and velocity, detectable with future μas to tens of μas astrometry. Such astrometric responses provide independent constraints on the geometric and kinematic structure of the extended emission region, complementary to traditional RM. In addition, astrometric RM is more sensitive to infer the inclination of a flattened geometry and the rotation angle of the extended emission region.

  1. Transboundary geophysical mapping of geological elements and salinity distribution critical for the assessment of future sea water intrusion in response to sea level rise

    DEFF Research Database (Denmark)

    Joergensen, F.; Scheer, W.; Thomsen, S.

    2012-01-01

    Geophysical techniques are increasingly being used as tools for characterising the subsurface, and they are generally required to develop subsurface models that properly delineate the distribution of aquifers and aquitards, salt/freshwater interfaces, and geological structures that affect......, and sand aquifers are all examples of geological structures mapped by the geophysical data that control groundwater flow and to some extent hydrochemistry. Additionally, the data provide an excellent picture of the salinity distribution in the area and thus provide important information on the salt...... revealed. The mapped salinity distribution indicates preferential flow paths through and along specific geological structures within the area. The effects of a future sea level rise on the groundwater system and groundwater chemistry are discussed with special emphasis on the importance of knowing...

  2. MAPPING INNOVATION

    DEFF Research Database (Denmark)

    Thuesen, Christian Langhoff; Koch, Christian

    2011-01-01

    By adopting a theoretical framework from strategic niche management research (SNM) this paper presents an analysis of the innovation system of the Danish Construction industry. The analysis shows a multifaceted landscape of innovation around an existing regime, built around existing ways of working...... and developed over generations. The regime is challenged from various niches and the socio-technical landscape through trends as globalization. Three niches (Lean Construction, BIM and System Deliveries) are subject to a detailed analysis showing partly incompatible rationales and various degrees of innovation...... potential. The paper further discusses how existing policymaking operates in a number of tensions one being between government and governance. Based on the concepts from SNM the paper introduces an innovation map in order to support the development of meta-governance policymaking. By mapping some...

  3. Mapping filmmaking

    DEFF Research Database (Denmark)

    Gilje, Øystein; Frølunde, Lisbeth; Lindstrand, Fredrik

    2010-01-01

    This chapter concerns mapping patterns in regards to how young filmmakers (age 15 – 20) in the Scandinavian countries learn about filmmaking. To uncover the patterns, we present portraits of four young filmmakers who participated in the Scandinavian research project Making a filmmaker. The focus ...... is on their learning practices and how they create ‘learning paths’ in relation to resources in diverse learning contexts, whether formal, non-formal and informal contexts.......This chapter concerns mapping patterns in regards to how young filmmakers (age 15 – 20) in the Scandinavian countries learn about filmmaking. To uncover the patterns, we present portraits of four young filmmakers who participated in the Scandinavian research project Making a filmmaker. The focus...

  4. Transboundary geophysical mapping of geological elements and salinity distribution critical for the assessment of future sea water intrusion in response to sea level rise

    Directory of Open Access Journals (Sweden)

    F. Jørgensen

    2012-07-01

    Full Text Available Geophysical techniques are increasingly being used as tools for characterising the subsurface, and they are generally required to develop subsurface models that properly delineate the distribution of aquifers and aquitards, salt/freshwater interfaces, and geological structures that affect groundwater flow. In a study area covering 730 km2 across the border between Germany and Denmark, a combination of an airborne electromagnetic survey (performed with the SkyTEM system, a high-resolution seismic survey and borehole logging has been used in an integrated mapping of important geological, physical and chemical features of the subsurface. The spacing between flight lines is 200–250 m which gives a total of about 3200 line km. About 38 km of seismic lines have been collected. Faults bordering a graben structure, buried tunnel valleys, glaciotectonic thrust complexes, marine clay units, and sand aquifers are all examples of geological structures mapped by the geophysical data that control groundwater flow and to some extent hydrochemistry. Additionally, the data provide an excellent picture of the salinity distribution in the area and thus provide important information on the salt/freshwater boundary and the chemical status of groundwater. Although the westernmost part of the study area along the North Sea coast is saturated with saline water and the TEM data therefore are strongly influenced by the increased electrical conductivity there, buried valleys and other geological elements are still revealed. The mapped salinity distribution indicates preferential flow paths through and along specific geological structures within the area. The effects of a future sea level rise on the groundwater system and groundwater chemistry are discussed with special emphasis on the importance of knowing the existence, distribution and geometry of the mapped geological elements, and their control on the groundwater salinity distribution is assessed.

  5. Brain Region-Specific Expression of Genes Mapped within Quantitative Trait Loci for Behavioral Responsiveness to Acute Stress in Fisher 344 and Wistar Kyoto Male Rats (Open Access Postprint)

    Science.gov (United States)

    2018-03-12

    responsiveness to acute stress in Fisher 344 and Wistar Kyoto male rats. PLoS ONE 13(3): e0194293. https://doi. org /10.1371/journal.pone.0194293 Editor...mapping analysis of complex traits in outbred rats. Nature genetics. 2013; 45(7): https://doi. org /10.1038/ng.2644 PMC3821058. PMID: 23708188 15...assisted breeding of congenic mouse strains. Nature Genetics. 1997; 17:280. https://doi. org /10.1038/ng1197-280 PMID: 9354790 21. The SC. SNP and haplotype

  6. NOAA Coastal Mapping Remote Sensing Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Remote Sensing Division is responsible for providing data to support the Coastal Mapping Program, Emergency Response efforts, and the Aeronautical Survey Program...

  7. Brain Region-Specific Expression of Genes Mapped within Quantitative Trait Loci for Behavioral Responsiveness to Acute Stress in Fisher 344 and Wistar Kyoto Male Rats (Postprint)

    Science.gov (United States)

    2018-03-12

    stress in Fisher 344 and Wistar Kyoto male rats. PLoS ONE 13(3): e0194293. https://doi. org /10.1371/journal.pone.0194293 Editor: Alexandra Kavushansky...complex traits in outbred rats. Nature genetics. 2013; 45(7): https://doi. org /10.1038/ng.2644 PMC3821058. PMID: 23708188 15. Ahmadiyeh N, Churchill GA...congenic mouse strains. Nature Genetics. 1997; 17:280. https://doi. org /10.1038/ng1197-280 PMID: 9354790 21. The SC. SNP and haplotype mapping for genetic

  8. Mapping Resilience

    DEFF Research Database (Denmark)

    Carruth, Susan

    2015-01-01

    by planners when aiming to construct resilient energy plans. It concludes that a graphical language has the potential to be a significant tool, flexibly facilitating cross-disciplinary communication and decision-making, while emphasising that its role is to support imaginative, resilient planning rather than...... the relationship between resilience and energy planning, suggesting that planning in, and with, time is a core necessity in this domain. It then reviews four examples of graphically mapping with time, highlighting some of the key challenges, before tentatively proposing a graphical language to be employed...

  9. Mapping of

    Directory of Open Access Journals (Sweden)

    Sayed M. Arafat

    2014-06-01

    Full Text Available Land cover map of North Sinai was produced based on the FAO-Land Cover Classification System (LCCS of 2004. The standard FAO classification scheme provides a standardized system of classification that can be used to analyze spatial and temporal land cover variability in the study area. This approach also has the advantage of facilitating the integration of Sinai land cover mapping products to be included with the regional and global land cover datasets. The total study area is covering a total area of 20,310.4 km2 (203,104 hectare. The landscape classification was based on SPOT4 data acquired in 2011 using combined multispectral bands of 20 m spatial resolution. Geographic Information System (GIS was used to manipulate the attributed layers of classification in order to reach the maximum possible accuracy. GIS was also used to include all necessary information. The identified vegetative land cover classes of the study area are irrigated herbaceous crops, irrigated tree crops and rain fed tree crops. The non-vegetated land covers in the study area include bare rock, bare soils (stony, very stony and salt crusts, loose and shifting sands and sand dunes. The water bodies were classified as artificial perennial water bodies (fish ponds and irrigated canals and natural perennial water bodies as lakes (standing. The artificial surfaces include linear and non-linear features.

  10. Fine-scale linkage mapping reveals a small set of candidate genes influencing honey bee grooming behavior in response to Varroa mites.

    Directory of Open Access Journals (Sweden)

    Miguel E Arechavaleta-Velasco

    Full Text Available Populations of honey bees in North America have been experiencing high annual colony mortality for 15-20 years. Many apicultural researchers believe that introduced parasites called Varroa mites (V. destructor are the most important factor in colony deaths. One important resistance mechanism that limits mite population growth in colonies is the ability of some lines of honey bees to groom mites from their bodies. To search for genes influencing this trait, we used an Illumina Bead Station genotyping array to determine the genotypes of several hundred worker bees at over a thousand single-nucleotide polymorphisms in a family that was apparently segregating for alleles influencing this behavior. Linkage analyses provided a genetic map with 1,313 markers anchored to genome sequence. Genotypes were analyzed for association with grooming behavior, measured as the time that individual bees took to initiate grooming after mites were placed on their thoraces. Quantitative-trait-locus interval mapping identified a single chromosomal region that was significant at the chromosome-wide level (p<0.05 on chromosome 5 with a LOD score of 2.72. The 95% confidence interval for quantitative trait locus location contained only 27 genes (honey bee official gene annotation set 2 including Atlastin, Ataxin and Neurexin-1 (AmNrx1, which have potential neurodevelopmental and behavioral effects. Atlastin and Ataxin homologs are associated with neurological diseases in humans. AmNrx1 codes for a presynaptic protein with many alternatively spliced isoforms. Neurexin-1 influences the growth, maintenance and maturation of synapses in the brain, as well as the type of receptors most prominent within synapses. Neurexin-1 has also been associated with autism spectrum disorder and schizophrenia in humans, and self-grooming behavior in mice.

  11. The transcriptional response to the inactivation of the PaMpk1 and PaMpk2 MAP kinase pathways in Podospora anserina.

    Science.gov (United States)

    Bidard, Frédérique; Coppin, Evelyne; Silar, Philippe

    2012-08-01

    Transcription pattern during mycelium growth of Podospora anserina was assayed by microarray analysis in wild type and in mutants affected in the MAP kinase genes PaMpk1 and PaMpk2 and in the NADPH oxidase gene PaNox1. 15% of the genes have their expression modified by a factor two or more as growth proceeds in wild type. The genes whose expression is modified during growth in P. anserina are either not conserved or differently regulated in Neurospora crassa and Aspergillus niger, two fungi for which transcriptome data during growth are available. The P. anserina mutants display a similar alteration of their transcriptome profile, with nearly 1000 genes affected similarly in the three mutants, accounting for their similar growth phenotypes. Yet, each mutant has its specific set of modified transcripts, in line with particular phenotypes exhibited by each mutant. Again, there is limited conservation during evolution of the genes regulated at the transcription level by MAP kinases, as indicated by the comparison the P. anserina data, with those of Aspergillus fumigatus and N. crassa, two fungi for which gene expression data are available for mutants of the MAPK pathways. Among the genes regulated in wild type and affected in the mutants, those involved in carbohydrate and secondary metabolisms appear prominent. The vast majority of the genes differentially expressed are of unknown function. Availability of their transcription profile at various stages of development should help to decipher their role in fungal physiology and development. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

    Science.gov (United States)

    Malhotra, Deepti; Portales-Casamar, Elodie; Singh, Anju; Srivastava, Siddhartha; Arenillas, David; Happel, Christine; Shyr, Casper; Wakabayashi, Nobunao; Kensler, Thomas W.; Wasserman, Wyeth W.; Biswal, Shyam

    2010-01-01

    The Nrf2 (nuclear factor E2 p45-related factor 2) transcription factor responds to diverse oxidative and electrophilic environmental stresses by circumventing repression by Keap1, translocating to the nucleus, and activating cytoprotective genes. Nrf2 responses provide protection against chemical carcinogenesis, chronic inflammation, neurodegeneration, emphysema, asthma and sepsis in murine models. Nrf2 regulates the expression of a plethora of genes that detoxify oxidants and electrophiles and repair or remove damaged macromolecules, such as through proteasomal processing. However, many direct targets of Nrf2 remain undefined. Here, mouse embryonic fibroblasts (MEF) with either constitutive nuclear accumulation (Keap1−/−) or depletion (Nrf2−/−) of Nrf2 were utilized to perform chromatin-immunoprecipitation with parallel sequencing (ChIP-Seq) and global transcription profiling. This unique Nrf2 ChIP-Seq dataset is highly enriched for Nrf2-binding motifs. Integrating ChIP-Seq and microarray analyses, we identified 645 basal and 654 inducible direct targets of Nrf2, with 244 genes at the intersection. Modulated pathways in stress response and cell proliferation distinguish the inducible and basal programs. Results were confirmed in an in vivo stress model of cigarette smoke-exposed mice. This study reveals global circuitry of the Nrf2 stress response emphasizing Nrf2 as a central node in cell survival response. PMID:20460467

  13. Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T.

    Science.gov (United States)

    Longo, Dario Livio; Dastrù, Walter; Digilio, Giuseppe; Keupp, Jochen; Langereis, Sander; Lanzardo, Stefania; Prestigio, Simone; Steinbach, Oliver; Terreno, Enzo; Uggeri, Fulvio; Aime, Silvio

    2011-01-01

    Iopamidol (Isovue®-Bracco Diagnostic Inc.) is a clinically approved X-Ray contrast agent used in the last 30 years for a wide variety of diagnostic applications with a very good clinical acceptance. Iopamidol contains two types of amide functionalities that can be exploited for the generation of chemical exchange saturation transfer effect. The exchange rate of the two amide proton pools is markedly pH-dependent. Thus, a ratiometric method for pH assessment has been set-up based on the comparison of the saturation transfer effects induced by selective irradiation of the two resonances. This ratiometric approach allows to rule out the concentration effect of the contrast agent and provides accurate pH measurements in the 5.5-7.4 range. Upon injection of Iopamidol into healthy mice, it has been possible to acquire pH maps of kidney regions. Furthermore, it has been also shown that the proposed method is able to report about pH-changes induced in control mice fed with acidified or basified water for a period of a week before image acquisition. © 2010 Wiley-Liss, Inc.

  14. Mitogen activated protein kinase 6 and MAP kinase phosphatase 1 are involved in the response of Arabidopsis roots to L-glutamate.

    Science.gov (United States)

    López-Bucio, Jesús Salvador; Raya-González, Javier; Ravelo-Ortega, Gustavo; Ruiz-Herrera, León Francisco; Ramos-Vega, Maricela; León, Patricia; López-Bucio, José; Guevara-García, Ángel Arturo

    2018-03-01

    The function and components of L-glutamate signaling pathways in plants have just begun to be elucidated. Here, using a combination of genetic and biochemical strategies, we demonstrated that a MAPK module is involved in the control of root developmental responses to this amino acid. Root system architecture plays an essential role in plant adaptation to biotic and abiotic factors via adjusting signal transduction and gene expression. L-Glutamate (L-Glu), an amino acid with neurotransmitter functions in animals, inhibits root growth, but the underlying genetic mechanisms are poorly understood. Through a combination of genetic analysis, in-gel kinase assays, detailed cell elongation and division measurements and confocal analysis of expression of auxin, quiescent center and stem cell niche related genes, the critical roles of L-Glu in primary root growth acting through the mitogen-activated protein kinase 6 (MPK6) and the dual specificity serine-threonine-tyrosine phosphatase MKP1 could be revealed. In-gel phosphorylation assays revealed a rapid and dose-dependent induction of MPK6 and MPK3 activities in wild-type Arabidopsis seedlings in response to L-Glu. Mutations in MPK6 or MKP1 reduced or increased root cell division and elongation in response to L-Glu, possibly modulating auxin transport and/or response, but in a PLETHORA1 and 2 independent manner. Our data highlight MPK6 and MKP1 as components of an L-Glu pathway linking the auxin response, and cell division for primary root growth.

  15. Seismic hazard maps for Haiti

    Science.gov (United States)

    Frankel, Arthur; Harmsen, Stephen; Mueller, Charles; Calais, Eric; Haase, Jennifer

    2011-01-01

    We have produced probabilistic seismic hazard maps of Haiti for peak ground acceleration and response spectral accelerations that include the hazard from the major crustal faults, subduction zones, and background earthquakes. The hazard from the Enriquillo-Plantain Garden, Septentrional, and Matheux-Neiba fault zones was estimated using fault slip rates determined from GPS measurements. The hazard from the subduction zones along the northern and southeastern coasts of Hispaniola was calculated from slip rates derived from GPS data and the overall plate motion. Hazard maps were made for a firm-rock site condition and for a grid of shallow shear-wave velocities estimated from topographic slope. The maps show substantial hazard throughout Haiti, with the highest hazard in Haiti along the Enriquillo-Plantain Garden and Septentrional fault zones. The Matheux-Neiba Fault exhibits high hazard in the maps for 2% probability of exceedance in 50 years, although its slip rate is poorly constrained.

  16. Human Mind Maps

    Science.gov (United States)

    Glass, Tom

    2016-01-01

    When students generate mind maps, or concept maps, the maps are usually on paper, computer screens, or a blackboard. Human Mind Maps require few resources and little preparation. The main requirements are space where students can move around and a little creativity and imagination. Mind maps can be used for a variety of purposes, and Human Mind…

  17. An MRI Method To Map Tumor Hypoxia Using Red Blood Cells Loaded with a pO2-Responsive Gd-Agent.

    Science.gov (United States)

    Di Gregorio, Enza; Ferrauto, Giuseppe; Gianolio, Eliana; Lanzardo, Stefania; Carrera, Carla; Fedeli, Franco; Aime, Silvio

    2015-08-25

    Hypoxia is a typical hallmark of many solid tumors and often leads to therapy resistance and the development of a more aggressive cancer phenotype. Oxygen content in tissues has been evaluated using numerous different methods for several imaging modalities, but none has yet reached the required standard of spatial and temporal resolution. Magnetic Resonance Imaging (MRI) appears to be the technique of choice and several pO2-responsive probes have been designed for it over the years. In vivo translation is often hampered in Gd-relaxation agents as it is not possible to separate effects that arise from changes in local concentration from those associated with responsive properties. A novel procedure for the MRI based assessment of hypoxia is reported herein. The method relies on the combined use of Gd-DOTP- and Gd-HPDO3A-labeled red blood cells (RBCs) where the first probe acts as a vascular oxygenation-responsive agent, while the second reports the local labeled RBC concentration in a transplanted breast tumor mouse model. The MRI assessment of oxygenation state has been validated by photoacoustic imaging and ex vivo immunofluorescence. The method refines tumor staging in preclinical models and makes possible an accurate monitoring of the relationship between oxygenation and tumor growth.

  18. Mapping the northern plains of Mars: origins, evolution and response to climate change - a new overview of the recent ice-related landforms in Utopia Planitia

    Science.gov (United States)

    Costard, Francois; Sejourne, Antoine; Losiak, Ania; Swirad, Zusanna; Balm, Matthew; Conway, Susan; Gallagher, Colman; van-Gassel, Stephan; Hauber, Ernst; Johnsson, Andreas; Kereszturi, Akos; Platz, Thomas; Ramsdale, Jason; Reiss, Dennis; Skinner, James

    2015-04-01

    An ISSI (International Space Science Institute) international team has been convened to study the Northern Plain of Mars. The northern plains of Mars are extensive, geologically young, low-lying areas that contrast in age and relief to Mars' older, heavily cratered, southern highlands. Mars' northern plains are characterised by a wealth of landforms and landscapes that have been inferred to be related to the presence of ice or ice-rich material. Such landforms include 'scalloped' pits and depressions, polygonally-patterned grounds, and viscous flow features similar in form to terrestrial glacial or ice-sheet landforms. Furthermore, new (within the last few years) impact craters have exposed ice in the northern plains, and spectral data from orbiting instruments have revealed the presence of tens of percent by weight of water within the upper most ~50 cm of the martian surface at high latitudes. The western Utopia Planitia contains numerous relatively young ice-related landforms (Utopia Planitia along a long strip from ~30N to ~80N latitude and about 250km wide. The goals are to: (i) map the geographical distribution of the ice-related landforms; (ii) identify their association with subtly-expressed geological units and; (iii) discuss the climatic modifications of the ice-rich permafrost in UP. Our work combines a study with CTX (5-6 m/pixel) and HRSC (~12.5-50 m/pixel) images, supported by higher resolution HiRISE (25 cm/pixel) and MOC (~2 m/pixel) and a comparison with analogous landforms on Earth.

  19. Fine mapping of S37, a locus responsible for pollen and embryo sac sterility in hybrids between Oryza sativa L. and O. glaberrima Steud.

    Science.gov (United States)

    Shen, Yumin; Zhao, Zhigang; Ma, Hongyang; Bian, Xiaofeng; Yu, Yang; Yu, Xiaowen; Chen, Haiyuan; Liu, Linglong; Zhang, Wenwei; Jiang, Ling; Zhou, Jiawu; Tao, Dayun; Wan, Jianmin

    2015-11-01

    Hybrid sterility locus S37 between Oryza glaberrima and Oryza sativa results in both pollen and embryo sac sterility. Interspecific crossing between African cultivated rice Oryza glaberrima and Oryza sativa cultivars is hindered by hybrid sterility. To dissect the mechanism of interspecific hybrid sterility, we developed a near-isogenic line (NIL)-S37 using Dianjingyou1 (DJY1) as the recipient parent and an African cultivated rice variety as the donor parent. Empty pollen and embryo sac sterility were observed in F1 hybrids between DJY1 and NIL-S37. Cytological analyses showed that pollen abortion in the F1 hybrids occurred at the late binucleate stage due to a failure of starch accumulation in pollen grains. In addition, partial abortion of the embryo sac in the F1 hybrid was observed during function megaspore developing into mature embryo sac. Molecular analysis revealed that the semi-sterility was largely caused by the abortion of male and female gametophytes carrying the S37 allele from DJY1. A population of 25,600 plants derived from the hybrid DJY1/NIL-S37 was developed to fine map S37. Based on the physical location of molecular markers, S37 locus was finally delimited to a region of 205 kb on the short arm of chromosome 1 in terms of reference sequences of cv. Nipponbare. Interestingly, an about 97-kb DNA segment was deleted in the NIL-S37 based on BAC clone information of O. glaberrima. Fifty-four open reading frames (ORF) were predicted in this 205-kb region of DJY1, whereas only 31 ORFs were in that of NIL-S37. These results are valuable for cloning of S37 gene and further breaking reproductive isolation between Oryza glaberrima and Oryza sativa cultivars, as well as marker-assisted transferring of the corresponding neutral allele in rice breeding programs.

  20. Validation and uncertainty quantification of detector response functions for a 1″×2″ NaI collimated detector intended for inverse radioisotope source mapping applications

    Science.gov (United States)

    Nelson, N.; Azmy, Y.; Gardner, R. P.; Mattingly, J.; Smith, R.; Worrall, L. G.; Dewji, S.

    2017-11-01

    Detector response functions (DRFs) are often used for inverse analysis. We compute the DRF of a sodium iodide (NaI) nuclear material holdup field detector using the code named g03 developed by the Center for Engineering Applications of Radioisotopes (CEAR) at NC State University. Three measurement campaigns were performed in order to validate the DRF's constructed by g03: on-axis detection of calibration sources, off-axis measurements of a highly enriched uranium (HEU) disk, and on-axis measurements of the HEU disk with steel plates inserted between the source and the detector to provide attenuation. Furthermore, this work quantifies the uncertainty of the Monte Carlo simulations used in and with g03, as well as the uncertainties associated with each semi-empirical model employed in the full DRF representation. Overall, for the calibration source measurements, the response computed by the DRF for the prediction of the full-energy peak region of responses was good, i.e. within two standard deviations of the experimental response. In contrast, the DRF tended to overestimate the Compton continuum by about 45-65% due to inadequate tuning of the electron range multiplier fit variable that empirically represents physics associated with electron transport that is not modeled explicitly in g03. For the HEU disk measurements, computed DRF responses tended to significantly underestimate (more than 20%) the secondary full-energy peaks (any peak of lower energy than the highest-energy peak computed) due to scattering in the detector collimator and aluminum can, which is not included in the g03 model. We ran a sufficiently large number of histories to ensure for all of the Monte Carlo simulations that the statistical uncertainties were lower than their experimental counterpart's Poisson uncertainties. The uncertainties associated with least-squares fits to the experimental data tended to have parameter relative standard deviations lower than the peak channel relative standard

  1. Maps & minds : mapping through the ages

    Science.gov (United States)

    ,

    1984-01-01

    Throughout time, maps have expressed our understanding of our world. Human affairs have been influenced strongly by the quality of maps available to us at the major turning points in our history. "Maps & Minds" traces the ebb and flow of a few central ideas in the mainstream of mapping. Our expanding knowledge of our cosmic neighborhood stems largely from a small number of simple but grand ideas, vigorously pursued.

  2. Lunar Map Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — The Lunar Map Catalog includes various maps of the moon's surface, including Apollo landing sites; earthside, farside, and polar charts; photography index maps; zone...

  3. Baby Brain Map

    Science.gov (United States)

    ... a Member Home Resources & Services Professional Resource Baby Brain Map Mar 17, 2016 The Brain Map was adapted in 2006 by ZERO TO ... supports Adobe Flash Player. To view the Baby Brain Map, please visit this page on a browser ...

  4. Snapshots for Semantic Maps

    National Research Council Canada - National Science Library

    Nielsen, Curtis W; Ricks, Bob; Goodrich, Michael A; Bruemmer, David; Few, Doug; Walton, Miles

    2004-01-01

    .... Semantic maps are a relatively new approach to information presentation. Semantic maps provide more detail about an environment than typical maps because they are augmented by icons or symbols that provide meaning for places or objects of interest...

  5. Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A.

    Directory of Open Access Journals (Sweden)

    Rajesh Singh

    2010-02-01

    Full Text Available Understanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Several proteins and polysaccharide capsule have recently been implicated in the virulence of and protective immunity against Streptococcus pneumonia. Pneumococcal surface protein A (PspA is highly conserved among S. pneumonia strains, inhibits complement activation, binds lactoferrin, elicits protective systemic immunity against pneumococcal infection, and is necessary for full pneumococcal virulence. Identification of PspA peptides that optimally bind human leukocyte antigen (HLA would greatly contribute to global vaccine efforts, but this is hindered by the multitude of HLA polymorphisms. Here, we have used an experimental data set of 54 PspA peptides and in silico methods to predict peptide binding to HLA and murine major histocompatibility complex (MHC class II. We also characterized spleen- and cervical lymph node (CLN-derived helper T lymphocyte (HTL cytokine responses to these peptides after S. pneumonia strain EF3030-challenge in mice. Individual, yet overlapping peptides, 15 amino acids in length revealed residues 199 to 246 of PspA (PspA(199-246 consistently caused the greatest IFN-gamma, IL-2, IL-5 and proliferation as well as moderate IL-10 and IL-4 responses by ex vivo stimulated splenic and CLN CD4(+ T cells isolated from S. pneumonia strain EF3030-challeged F(1 (B6xBALB/c mice. IEDB, RANKPEP, SVMHC, MHCPred, and SYFPEITHI in silico analysis tools revealed peptides in PspA(199-246 also interact with a broad range of HLA-DR, -DQ, and -DP allelles. These data suggest that predicted MHC class II-peptide binding affinities do not always correlate with T helper (Th cytokine or proliferative responses to PspA peptides, but when used together with in vivo validation can be a useful tool to choose candidate pneumococcal HTL epitopes.

  6. Mapping the Distribution of Sand Live Oak (Quercus geminata) and Determining Growth Responses to Hurricane Katrina (2005) on Cat Island, Mississippi

    Science.gov (United States)

    Funderburk, W.; Carter, G. A.; Harley, G. L.

    2013-12-01

    William R. Funderburk, Gregory A. Carter, Grant Harley Gulf Coast Geospatial Center, University of Southern Mississippi Department of Geography and Geology Stennis Space Center, MS 39529 U.S.A. william.funderburk@usm.edu The Mississippi-Alabama barrier islands serve to buffer mainland coastal areas from the impacts of hurricanes and other extreme weather events. On August 29, 2005, they were impacted heavily by the wind, waves, and storm surges of Hurricane Katrina. The purpose of this study is to determine the growth responses of Quercus geminata, a dominant tree species on Cat Island, MS, in relation to the impact of Hurricane Katrina. Remotely sensed data was utilized in conjunction with ground data to assess growth response post Hurricane Katrina. The main objectives of this study were: 1) determine growth response of Q. geminata through tree ring analysis; 2) understand how Q. geminata adapted to intense weather and climatic phenomena on Cat Island. The hypotheses tested were: 1) growth rates of Q. geminata on Cat Island were decreased by the impact of Hurricane Katrina 2) trees at higher elevations survived or recovered while trees at lower elevations did not recover or died. Decadal scale stability is required for forest stand development on siliciclastic barrier islands. Thus, monitoring the distribution of forest climax community species is key to understanding siliciclastic, subsiding, barrier island geomorphic processes and their relationships to successional patterns and growth rates. Preliminary results indicate that Q. geminata produces a faint growth ring, survive for at least two to three hundred years and is well-adapted to frequent salt water flooding. Cat Island: False color Image

  7. The National Map: from geography to mapping and back again

    Science.gov (United States)

    Kelmelis, John A.; DeMulder, Mark L.; Ogrosky, Charles E.; Van Driel, J. Nicholas; Ryan, Barbara J.

    2003-01-01

    When the means of production for national base mapping were capital intensive, required large production facilities, and had ill-defined markets, Federal Government mapping agencies were the primary providers of the spatial data needed for economic development, environmental management, and national defense. With desktop geographic information systems now ubiquitous, source data available as a commodity from private industry, and the realization that many complex problems faced by society need far more and different kinds of spatial data for their solutions, national mapping organizations must realign their business strategies to meet growing demand and anticipate the needs of a rapidly changing geographic information environment. The National Map of the United States builds on a sound historic foundation of describing and monitoring the land surface and adds a focused effort to produce improved understanding, modeling, and prediction of land-surface change. These added dimensions bring to bear a broader spectrum of geographic science to address extant and emerging issues. Within the overarching construct of The National Map, the U.S. Geological Survey (USGS) is making a transition from data collector to guarantor of national data completeness; from producing paper maps to supporting an online, seamless, integrated database; and from simply describing the Nation’s landscape to linking these descriptions with increased scientific understanding. Implementing the full spectrum of geographic science addresses a myriad of public policy issues, including land and natural resource management, recreation, urban growth, human health, and emergency planning, response, and recovery. Neither these issues nor the science and technologies needed to deal with them are static. A robust research agenda is needed to understand these changes and realize The National Map vision. Initial successes have been achieved. These accomplishments demonstrate the utility of

  8. Mapping the brain pathways of traumatic memory: inactivation of protein kinase M zeta in different brain regions disrupts traumatic memory processes and attenuates traumatic stress responses in rats.

    Science.gov (United States)

    Cohen, Hagit; Kozlovsky, Nitsan; Matar, Michael A; Kaplan, Zeev; Zohar, Joseph

    2010-04-01

    Protein kinase M zeta (PKMzeta), a constitutively active isoform of protein kinase C, has been implicated in protein synthesis-dependent maintenance of long-term potentiation and memory storage in the brain. Recent studies reported that local application of ZIP, a membrane-permeant PKMzeta inhibitor, into the insular cortex (IC) of behaving rats abolished long-term memory of taste associations. This study assessed the long-term effects of local applications of ZIP microinjected immediately (1 h) or 10 days after predator scent stress exposure, in a controlled prospectively designed animal model for PTSD. Four brain structures known to be involved in memory processes and in anxiety were investigated: lateral ventricle (LV), dorsal hippocampus (DH), basolateral amygdala and IC. The outcome measures included behavior in an elevated plus maze and acoustic startle response 7 days after microinjection, and freezing behavior upon exposure to trauma-related cue 8 days after microinjection. Previously acquired/encoded memories associated with the IC were also assessed. Inactivation of PKMzeta in the LV or DH within 1h of exposure effectively reduced PTSD-like behavioral disruption and trauma cue response 8 days later. Inactivation of PKMzeta 10 days after exposure had equivalent effects only when administered in the IC. The effect was demonstrated to be specific for trauma memories, whereas previously acquired data were unaffected by the procedure. Predator scent related memories are located in different brain areas at different times beginning with an initial hippocampus-dependent consolidation process, and are eventually stored in the IC. These bring the IC to the forefront as a potential region of significance in processes related to traumatic stress-induced disorders. 2010 Elsevier B.V. and ECNP. All rights reserved.

  9. How to Write Home: (UnMapping the Politics of Place and Authorial Responsibility with Arundhati Roy’s The God of Small Things

    Directory of Open Access Journals (Sweden)

    Kelly Palmer

    2017-05-01

    Full Text Available Arundhati Roy’s 1997 Man Booker Prize-winning novel, The God of Small Things, was harshly criticised by Indian and international scholars alike for misrepresenting the cultural landscape of 1970s Kerala and greater India. Such criticisms deny Roy’s authority to represent Indian culture, and her right to speak of or accurately represent her birthplace. This essay draws from Roy’s first and only novel as a case study of place-based writing and its reception, then asks: can a responsibility to place or home ever be met in the genre of autoethnographic fiction? The first section of this essay surveys criticisms of Roy’s Kerala and reveals how transgressive place-based fiction can magnify negative stereotypes of a given culture. The second section investigates literature as a material artefact of place with value to sociology and cultural studies more broadly, thus situating the author as a social actor. Throughout, I reflect on my own autoethnographic writing practice, and devise questions about my personal onus to represent a fictionalised home that has the potential to (reshape Southeast Queensland in the cultural imagination.

  10. Mapping of a gene responsible for dermatitis in NOA (Naruto Research Institute Otsuka Atrichia) mice, an animal model of allergic dermatitis.

    Science.gov (United States)

    Natori, K; Tamari, M; Watanabe, O; Onouchi, Y; Shiomoto, Y; Kubo, S; Nakamura, Y

    1999-01-01

    The NOA (Naruto Research Institute Otsuka Atrichia) mouse is an animal model of allergic or atopic dermatitis, a condition characterized by ulcerative skin lesions with accumulation of mast cells and increased serum IgE. These features of the murine disease closely resemble human atopy and atopic disorders. We performed linkage analysis in NOA back-cross progeny, as a step toward identifying and isolating a gene responsible for the NOA phenotype. We crossed NOA mice with five other murine strains (C57BL/6J, IQI, C3H/HeJ, DBA/2J, and BALB/cByJ) and then bred back-cross animals. Using microsatellite markers, we scanned the entire genomes of 559 N2 offspring from the five parental strains. Linkage analysis revealed a significant association between ulcerative skin lesions and markers on murine chromosome 14. Statistical analysis indicated that the critical region was assigned to the vicinity of D14Mit236 and D14Mit160.

  11. Map server of Slovak Environmental Agency

    International Nuclear Information System (INIS)

    Koska, M.

    2005-01-01

    The Slovak Environmental Agency (SAZP) is professional organization of the Ministry of Environment of the Slovak Republic. In the area of informatics SAZP is responsible for operation of information system about environment in the Slovak Republic (ISE). The main goal of the ISE is collection, evaluating and accessing of relevant information about environment between organizations of state or administration, public administration, public, scientific institutes etc. SAZP uses technology of publishing of geo-space data so-called WEB maps (dynamic mapping) - maps are formed online. As a technologic part of information system is internet map server

  12. Mapping the Heart

    Science.gov (United States)

    Hulse, Grace

    2012-01-01

    In this article, the author describes how her fourth graders made ceramic heart maps. The impetus for this project came from reading "My Map Book" by Sara Fanelli. This book is a collection of quirky, hand-drawn and collaged maps that diagram a child's world. There are maps of her stomach, her day, her family, and her heart, among others. The…

  13. USGS Map Indices Overlay Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The USGS Map Indices service from The National Map (TNM) consists of 1x1 Degree, 30x60 Minute (100K), 15 Minute (63K), 7.5 Minute (24K), and 3.75 Minute grid...

  14. Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-κB pathway to alter cellular responses during hamster buccal pouch carcinogenesis

    International Nuclear Information System (INIS)

    Garg, Rachana; Ingle, Arvind; Maru, Girish

    2008-01-01

    The chemopreventive efficacy of turmeric has been established in experimental systems. However, its mechanism(s) of action are not fully elucidated in vivo. The present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis at 2, 4, 6, 10 and 12 weeks. Dietary turmeric (1%) led to decrease in DMBA-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modulatory effects on oncogene products and various cellular responses during HBP tumorigenesis. DMBA-induced expression of ras oncogene product, p21 and downstream target, the mitogen-activated protein kinases were significantly decreased by turmeric during HBP carcinogenesis. Turmeric also diminished the DMBA-induced mRNA expression of proto-oncogenes (c-jun, c-fos) and NF-κB, leading to decreased protein levels and in further attenuation of DMBA-induced AP-1/NF-κB DNA-binding in the buccal pouch nuclear extracts. Besides, buccal pouch of hamsters receiving turmeric diet showed significant alterations in DMBA-induced effects: (a) decrease in cell proliferation (diminished PCNA and Bcl2 expression), (b) enhanced apoptosis (increased expression of Bax, caspase-3 and apoptotic index), (c) decrease in inflammation (levels of Cox-2, the downstream target of AP-1/NF-κB, and PGE2) and (d) aberrant expression of differentiation markers, the cytokeratins (1, 5, 8, and 18). Together, the protective effects of dietary turmeric converge on augmenting apoptosis of the initiated cells and decreasing cell proliferation in DMBA-treated animals, which in turn, is reflected in decreased tumor burden, multiplicity and enhanced latency period. Some of these biomarkers are likely to be helpful in monitoring clinical trials and evaluating drug effect measurements

  15. 7. Annex II: Maps

    OpenAIRE

    Aeberli, Annina

    2012-01-01

    Map 1: States of South Sudan UN OCHA (2012) Republic of South Sudan – States, as of 15 July 2012, Reliefweb http://reliefweb.int/map/south-sudan-republic/republic-south-sudan-states-15-july-2012-reference-map, accessed 31 July 2012. Map 2: Counties of South Sudan UN OCHA (2012) Republic of South Sudan – Counties, as of 16 July 2012, Reliefweb http://reliefweb.int/map/south-sudan-republic/republic-south-sudan-counties-16-july-2012-reference-map, accessed 31 July 2012. Map 3: Eastern Equato...

  16. Applicability of vulnerability maps

    International Nuclear Information System (INIS)

    Andersen, L.J.; Gosk, E.

    1989-01-01

    A number of aspects to vulnerability maps are discussed: the vulnerability concept, mapping purposes, possible users, and applicability of vulnerability maps. Problems associated with general-type vulnerability mapping, including large-scale maps, universal pollutant, and universal pollution scenario are also discussed. An alternative approach to vulnerability assessment - specific vulnerability mapping for limited areas, specific pollutant, and predefined pollution scenario - is suggested. A simplification of the vulnerability concept is proposed in order to make vulnerability mapping more objective and by this means more comparable. An extension of the vulnerability concept to the rest of the hydrogeological cycle (lakes, rivers, and the sea) is proposed. Some recommendations regarding future activities are given

  17. Differential maps, difference maps, interpolated maps, and long term prediction

    International Nuclear Information System (INIS)

    Talman, R.

    1988-06-01

    Mapping techniques may be thought to be attractive for the long term prediction of motion in accelerators, especially because a simple map can approximately represent an arbitrarily complicated lattice. The intention of this paper is to develop prejudices as to the validity of such methods by applying them to a simple, exactly solveable, example. It is shown that a numerical interpolation map, such as can be generated in the accelerator tracking program TEAPOT, predicts the evolution more accurately than an analytically derived differential map of the same order. Even so, in the presence of ''appreciable'' nonlinearity, it is shown to be impractical to achieve ''accurate'' prediction beyond some hundreds of cycles of oscillation. This suggests that the value of nonlinear maps is restricted to the parameterization of only the ''leading'' deviation from linearity. 41 refs., 6 figs

  18. VEGETATION MAPPING IN WETLANDS

    Directory of Open Access Journals (Sweden)

    F. PEDROTTI

    2004-01-01

    Full Text Available The current work examines the main aspects of wetland vegetation mapping, which can be summarized as analysis of the ecological-vegetational (ecotone gradients; vegetation complexes; relationships between vegetation distribution and geomorphology; vegetation of the hydrographic basin lo which the wetland in question belongs; vegetation monitoring with help of four vegetation maps: phytosociological map of the real and potential vegetation, map of vegetation dynamical tendencies, map of vegetation series.

  19. Expanding Thurston maps

    CERN Document Server

    Bonk, Mario

    2017-01-01

    This monograph is devoted to the study of the dynamics of expanding Thurston maps under iteration. A Thurston map is a branched covering map on a two-dimensional topological sphere such that each critical point of the map has a finite orbit under iteration. It is called expanding if, roughly speaking, preimages of a fine open cover of the underlying sphere under iterates of the map become finer and finer as the order of the iterate increases. Every expanding Thurston map gives rise to a fractal space, called its visual sphere. Many dynamical properties of the map are encoded in the geometry of this visual sphere. For example, an expanding Thurston map is topologically conjugate to a rational map if and only if its visual sphere is quasisymmetrically equivalent to the Riemann sphere. This relation between dynamics and fractal geometry is the main focus for the investigations in this work.

  20. Vaccination with map specific peptides reduces map burden in tissues of infected goats

    DEFF Research Database (Denmark)

    Melvang, Heidi Mikkelsen; Hassan, Sufia Butt; Thakur, Aneesh

    As an alternative to protein-based vaccines, we investigated the effect of post-exposure vaccination with Map specific peptides in a goat model aiming at developing a Map vaccine that will neither interfere with diagnosis of paratuberculosis nor bovine tuberculosis. Peptides were initially select...... in the unvaccinated control group seroconverted in ID Screen® ELISA at last sampling prior to euthanasia. These results indicate that a subunit vaccine against Map can induce a protective immune response against paratuberculosis in goats....

  1. Mapping in the cloud

    CERN Document Server

    Peterson, Michael P

    2014-01-01

    This engaging text provides a solid introduction to mapmaking in the era of cloud computing. It takes students through both the concepts and technology of modern cartography, geographic information systems (GIS), and Web-based mapping. Conceptual chapters delve into the meaning of maps and how they are developed, covering such topics as map layers, GIS tools, mobile mapping, and map animation. Methods chapters take a learn-by-doing approach to help students master application programming interfaces and build other technical skills for creating maps and making them available on the Internet. Th

  2. Mapping with Drupal

    CERN Document Server

    Palazzolo, Alan

    2011-01-01

    Build beautiful interactive maps on your Drupal website, and tell engaging visual stories with your data. This concise guide shows you how to create custom geographical maps from top to bottom, using Drupal 7 tools and out-of-the-box modules. You'll learn how mapping works in Drupal, with examples on how to use intuitive interfaces to map local events, businesses, groups, and other custom data. Although building maps with Drupal can be tricky, this book helps you navigate the system's complexities for creating sophisticated maps that match your site design. Get the knowledge and tools you ne

  3. Sensitivity mapping of the German North Sea Coast II. Data update and development of an operational model for precaution measures of oil spill response; Sensititivaetsraster Deutsche Nordseekueste II. Aktualisierung und Erstellung eines operationellen Modells zur Vorsorgeplanung bei der Oelbekaempfung

    Energy Technology Data Exchange (ETDEWEB)

    Bernem, K.H. van; Doerffer, R.; Heymann, K.; Kleeberg, U.; Krasemann, H.; Schiller, H. [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Kuestenforschung; Grohnert, A.; Reichert, J. [IfaB - Institut fuer Angewandte Biologie Freiburg/Niederelbe (Germany); Reichert, M. [ARCADIS, Rostock (Germany)

    2007-07-01

    The Wadden Sea is an area of tidal flats and salt marshes extending between the North Sea coasts of Denmark, Germany and the Netherlands. It has enormous value as a cleansing site for North Sea water, as a nursery for young fish and as a feeding ground for many bird species. Due to the proximity of important shipping routes and harbours, this region is especially threatened by oil spills. Thus, for oil spill response and precaution measures, a sensitivity study of the entire intertidal area was badly needed in order to assess and minimize the potential ecological and economical damage. Based on comprehensive field surveys and in close cooperation with the Central Command for Maritime Emergencies, an automated expert-model for the german part of Wadden Sea areas was developed at the Institute for Coastal Research (GKSS-Research Centre). As an operational model it will serve as important instrument for decision making processes, precautionary measures and the further design of oil spill response strategies. Since it is not possible to protect the entire German North Sea coast equally at all levels, oil spill contingency planning requires a more detailed classification. For this reason, individual soft bottom habitats, communities and stocks of saltmarshes, macrofauna, waterfowl and estuarine biotop types were evaluated and classified according to their vulnerability to oil pollution. Hence, the fieldwork for habitat mapping during 2003-2006 was a central part of the study. For this part, the experiences and results obtained from the previous GKSS-project ''Thematic mapping and sensitivity study of Intertidal flats'' during the years 1987-1992 served as an valuable basis. For example, the documentation of changes during these periods of observation provides information on stability features of the ecosystems. During the first project nearly 5000 locations were processed and characterised using about 70 parameters for each site. The in-situ mapping

  4. Meso(topoclimatic maps and mapping

    Directory of Open Access Journals (Sweden)

    Ladislav Plánka

    2007-06-01

    Full Text Available The atmospheric characteristics can be studied from many points of view, most often we talk about time and spatial standpoint. Application of time standpoint leads either to different kinds of the synoptic and prognostic maps production, which presents actual state of atmosphere in short time section in the past or in the near future or to the climatic maps production which presents longterm weather regime. Spatial standpoint then differs map works according to natural phenomenon proportions, whereas the scale of their graphic presentation can be different. It depends on production purpose of each work.In the paper there are analysed methods of mapping and climatic maps production, which display longterm regime of chosen atmospheric features. These athmosphere features are formed in interaction with land surface and also have direct influence on people and their activities throughout the country. At the same time they’re influenced by anthropogenic intervention to the landscape.

  5. Bayesian estimation of sensitivity and specificity of a commercial serum/milk ELISA against the Mycobacterium avium subsp. Paratuberculosis (MAP) antibody response for each lactation stage in Greek dairy sheep.

    Science.gov (United States)

    Angelidou, Elisavet; Kostoulas, Polychronis; Leontides, Leonidas

    2016-02-01

    A total of 854 paired milk and blood samples were collected from ewes of a Greek flock and used to estimate the sensitivity and specificity of a commercial ELISA for detection of Mycobacterium avium subsp. paratuberculosis (MAP) specific antibodies in each stage of lactation. We implemented Bayesian mixture models to derive the distributions of the test response for the healthy and the infected ewes. In the colostrum period, early, mid and late lactation stage the median values of the area under the curves (AUC) were 0.61 (95% credible interval: 0.50; 0.84), 0.61 (0.51;0.84), 0.65 (0.51;0.91), 0.65(0.51;0.89) for the serum ELISA and and 0.60 (0.50; 0.84), 0.61 (0.50; 0.84), 0.67(0.51; 0.91), 0.66(0.50; 0.90) for the milk ELISA, respectively. Both serum and milk ELISA had low to average overall discriminatory ability as measured by the area under the curves and comparable sensitivities and specificities at the recommended cutoffs. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Sensitivity mapping for oil spill response at the estuaries of the rivers Eider, Elbe, Weser and Ems; Sensitivitaetskartierung zur Oelbekaempfung an den Unterlaeufen von Eider, Elbe, Weser und Ems

    Energy Technology Data Exchange (ETDEWEB)

    Bernem, K.H. van; Krasemann, H. [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Kuestenforschung; Fleischmann, J.; Krueger, D.; Luebbe, T.P.

    2007-07-01

    During this project the estuaries of the rivers Eider, Elbe, Weser and Ems, meeting the North Sea, were evaluated with respect to their vulnerability against oil accidents. Thus a corresponding intention concerning the ''Wadden Sea'' at the German North Sea Coast could be proceeded and completed (GKSS 2007/2). The assessment of different watersides shall provide decision support for oil spill response. Only comparatively near-natural areas of river banks were incorporated, with the basic evaluation of their importance for nature conservation as well as their oil spill sensitivity. Socioeconomic characteristics have not been evaluated, but some important properties are depicted on charts by symbols. The data used for the evaluation process cover the types of biotopes, tidal flats, nesting/non-nesting birds, rare plants as well as fishes, morphological conditions of watersides and official area-categories (i.e. protected natural area). Riverine and intertidal areas are fundamentally differentiated. With respect to seasonal aspects, the evaluation was established for three different times of the year. The result of the evaluation process is the classification of the individual watersides into 4 classes of priority (for oil spill response) and 8 classes of sensitivity. The priorityclasses are depicted by colours and the sensitivity-classes by numbers on sea-charts as topographic background (scale 1:25.000). The evaluation results are delayed on printed as well as GIS-based maps, connected to a data base. The amount of very sensitive areas is higher in the estuaries of the rivers Elbe and Eider compared to Ems and Weser and shows the highest values at all rivers during spring. The evaluation procedure is automated to a large extend by use of linked tables and a decision tree of if/then-functions. The underlying structure provides for a reliable transformation of new data into the corresponding evaluation during updating processes. (orig.)

  7. Active Fire Mapping Program

    Science.gov (United States)

    Active Fire Mapping Program Current Large Incidents (Home) New Large Incidents Fire Detection Maps MODIS Satellite Imagery VIIRS Satellite Imagery Fire Detection GIS Data Fire Data in Google Earth ...

  8. Using maps in genealogy

    Science.gov (United States)

    ,

    2002-01-01

    In genealogical research, maps can provide clues to where our ancestors may have lived and where to look for written records about them. Beginners should master basic genealogical research techniques before starting to use topographic maps.

  9. NGS Survey Control Map

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NGS Survey Control Map provides a map of the US which allows you to find and display geodetic survey control points stored in the database of the National...

  10. National Pipeline Mapping System

    Data.gov (United States)

    Department of Transportation — The NPMS Public Map Viewer allows the general public to view maps of transmission pipelines, LNG plants, and breakout tanks in one selected county. Distribution and...

  11. NAIP Status Maps Gallery

    Data.gov (United States)

    Farm Service Agency, Department of Agriculture — NAIP Status Maps Gallery. These maps illustrate what aerial imagery collection is planned, whats been collected, when it is available and how it is available. These...

  12. Mapping Medicare Disparities Tool

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Office of Minority Health has designed an interactive map, the Mapping Medicare Disparities Tool, to identify areas of disparities between subgroups of...

  13. Recovery Action Mapping Tool

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Recovery Action Mapping Tool is a web map that allows users to visually interact with and query actions that were developed to recover species listed under the...

  14. Letter of Map Revision

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The National Flood Hazard Layer (NFHL) data incorporates all Digital Flood Insurance Rate Map(DFIRM) databases published by FEMA, and any Letters Of Map Revision...

  15. Contextualising Archaeological Information Through Interactive Maps

    Directory of Open Access Journals (Sweden)

    Ian Johnson

    2002-09-01

    Full Text Available Many web sites use maps delivered as non-interactive images. With the development of web-enabled mapping, new methods of presenting and contextualising archaeological and historical data are becoming available. However, most current examples are static views of contemporary framework data or specific time slices, and do not provide interactivity relating to the time dimension, which is so important to archaeology and related disciplines. In this article I look at some of the advantages of time-enabled interactive mapping and map animation in providing educational experiences to museum visitors and the web-browsing public. These will be illustrated through three example applications of the TimeMap methodology developed at the University of Sydney Archaeological Computing Laboratory: 1. the Sydney TimeMap kiosk at the Museum of Sydney; 2. an embedded Java mapping applet developed for MacquarieNet, a major Australian online educational encyclopaedia; and 3. the metadata clearinghouse mapping applet developed for the Electronic Cultural Atlas Initiative, Berkeley. In each of these examples, a wide range of resources are delivered through a time-enabled map interface which accesses live database data rather than pre-structured curated presentations of data. This flexibility brings its own challenges in providing intuitive pathways and appropriate levels of detail in response to free-ranging user enquiries. The paper outlines some of the approaches I have adopted to resolve these issues.

  16. Branched polynomial covering maps

    DEFF Research Database (Denmark)

    Hansen, Vagn Lundsgaard

    1999-01-01

    A Weierstrass polynomial with multiple roots in certain points leads to a branched covering map. With this as the guiding example, we formally define and study the notion of a branched polynomial covering map. We shall prove that many finite covering maps are polynomial outside a discrete branch...... set. Particular studies are made of branched polynomial covering maps arising from Riemann surfaces and from knots in the 3-sphere....

  17. Multi-moment maps

    DEFF Research Database (Denmark)

    Swann, Andrew Francis; Madsen, Thomas Bruun

    2012-01-01

    We introduce a notion of moment map adapted to actions of Lie groups that preserve a closed three-form. We show existence of our multi-moment maps in many circumstances, including mild topological assumptions on the underlying manifold. Such maps are also shown to exist for all groups whose second...

  18. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Fogh Olsen, Ole; Sporring, Jon

    2007-01-01

    . To address this problem we introduce a novel photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way we preserve the important illumination features......, while eliminating noise. We call our method diffusion based photon mapping....

  19. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Olsen, Ole Fogh; Sporring, Jon

    2006-01-01

    . To address this problem we introduce a novel photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way we preserve the important illumination features......, while eliminating noise. We call our method diffusion based photon mapping....

  20. On parabolic external maps

    DEFF Research Database (Denmark)

    Lomonaco, Luna; Petersen, Carsten Lunde; Shen, Weixiao

    2017-01-01

    We prove that any C1+BV degree d ≥ 2 circle covering h having all periodic orbits weakly expanding, is conjugate by a C1+BV diffeomorphism to a metrically expanding map. We use this to connect the space of parabolic external maps (coming from the theory of parabolic-like maps) to metrically expan...

  1. Digitised Maps in the Danish Map Collection

    OpenAIRE

    Annie Lenschau-Teglers; Vivi Gade Rønsberg

    2005-01-01

    As in the rest of the library world, The Royal Library in Copenhagen is in the process of digitising its collections. At the moment we are mainly working on the handwritten manual catalogue - but digitising the material is also a major working assignment. The Map Collection at The Royal Library has today divided the effort in digitising its materials into 3 groups: 1. Digitised maps as a vital addition to the records in our bibliographic database REX 2. Digitised maps presented as a Digital F...

  2. Mapping of wine industry

    OpenAIRE

    Віліна Пересадько; Надія Максименко; Катерина Біла

    2016-01-01

    Having reviewed a variety of approaches to understanding the essence of wine industry, having studied the modern ideas about the future of wine industry, having analyzed more than 50 maps from the Internet we have set the trends and special features of wine industry mapping in the world, such as: - the vast majority of maps displays the development of the industry at regional or national level, whereas there are practically no world maps; - wine-growing regions are represented on maps very un...

  3. Branched polynomial covering maps

    DEFF Research Database (Denmark)

    Hansen, Vagn Lundsgaard

    2002-01-01

    A Weierstrass polynomial with multiple roots in certain points leads to a branched covering map. With this as the guiding example, we formally define and study the notion of a branched polynomial covering map. We shall prove that many finite covering maps are polynomial outside a discrete branch ...... set. Particular studies are made of branched polynomial covering maps arising from Riemann surfaces and from knots in the 3-sphere. (C) 2001 Elsevier Science B.V. All rights reserved.......A Weierstrass polynomial with multiple roots in certain points leads to a branched covering map. With this as the guiding example, we formally define and study the notion of a branched polynomial covering map. We shall prove that many finite covering maps are polynomial outside a discrete branch...

  4. Minimalism through intraoperative functional mapping.

    Science.gov (United States)

    Berger, M S

    1996-01-01

    Intraoperative stimulation mapping may be used to avoid unnecessary risk to functional regions subserving language and sensori-motor pathways. Based on the data presented here, language localization is variable in the entire population, with only certainty existing for the inferior frontal region responsible for motor speech. Anatomical landmarks such as the anterior temporal tip for temporal lobe language sites and the posterior aspect of the lateral sphenoid wing for the frontal lobe language zones are unreliable in avoiding postoperative aphasias. Thus, individual mapping to identify essential language sites has the greatest likelihood of avoiding permanent deficits in naming, reading, and motor speech. In a similar approach, motor and sensory pathways from the cortex and underlying white matter may be reliably stimulated and mapped in both awake and asleep patients. Although these techniques require an additional operative time and equipment nominally priced, the result is often gratifying, as postoperative morbidity has been greatly reduced in the process of incorporating these surgical strategies. The patients quality of life is improved in terms of seizure control, with or without antiepileptic drugs. This avoids having to perform a second costly operative procedure, which is routinely done when extraoperative stimulation and recording is done via subdural grids. In addition, an aggressive tumor resection at the initial operation lengthens the time to tumor recurrence and often obviates the need for a subsequent reoperation. Thus, intraoperative functional mapping may be best alluded to as a surgical technique that results in "minimalism in the long term".

  5. Stakeholder mapping of CSR in Switzerland

    OpenAIRE

    Looser, S; Wehrmeyer, WCH

    2015-01-01

    Purpose – This paper aims to investigate, using stakeholder map methodology, showing power, urgency, legitimacy and concerns of different actors, the current state of corporate social responsibility (CSR) in Switzerland. Previous research on CSR in Europe has made few attempts to identify stakeholders and their contribution to this topic. Design/methodology/approach – To derive this map, publicly available documents were explored, augmented by 27 interviews with key stakeholders (consumers, m...

  6. On palaeogeographic map

    Directory of Open Access Journals (Sweden)

    Zeng-Zhao Feng

    2016-01-01

    Full Text Available The palaeogeographic map is a graphic representation of physical geographical characteristics in geological history periods and human history periods. It is the most important result of palaeogeographic study. The author, as the Editor-in-Chief of Journal of Palaeogeography, Chinese Edition and English Edition, aimed at the problems of the articles submitted to and published in the Journal of Palaeogeography in recent years and the relevant papers and books of others, and integrated with his practice of palaeogeographic study and mapping, wrote this paper. The content mainly includes the data of palaeogeographic mapping, the problems of palaeogeographic mapping method, the “Single factor analysis and multifactor comprehensive mapping method —— Methodology of quantitative lithofacies palaeogeography”, i.e., the “4 steps mapping method”, the nomenclature of each palaeogeographic unit in palaeogeographic map, the explanation of each palaeogeographic unit in palaeogeographic map, the explanation of significance of palaeogeographic map and palaeogeographic article, the evaluative standards of palaeogeographic map and palaeogeographic article, and the self-evaluation. Criticisms and corrections are welcome.

  7. Mapping Urban Social Divisions

    Directory of Open Access Journals (Sweden)

    Susan Ball

    2010-05-01

    Full Text Available Against the background of increased levels of interest in space and images beyond the field of geography, this article (re- introduces earlier work on the semiotics of maps undertaken by geographers in the 1960s. The data limitations, purpose and cultural context in which a user interprets a map's codes and conventions are highlighted in this work, which remains relevant to the interpretation of maps—new and old—forty years later. By means of drawing on geography's contribution to the semiotics of maps, the article goes on to examine the concept of urban social divisions as represented in map images. Using a small number of map images, including two of the most widely known maps of urban social division in Europe and North America, the roles of context, data and purpose in the production and interpretation of maps are discussed. By presenting the examples chronologically the article shows that although advances in data collection and manipulation have allowed researchers to combine different social variables in maps of social division, and to interact with map images, work by geographers on the semiotics of maps is no less relevant today than when it was first proposed forty years ago. URN: urn:nbn:de:0114-fqs1002372

  8. Going beyond the flood insurance rate map: insights from flood hazard map co-production

    Directory of Open Access Journals (Sweden)

    A. Luke

    2018-04-01

    Full Text Available Flood hazard mapping in the United States (US is deeply tied to the National Flood Insurance Program (NFIP. Consequently, publicly available flood maps provide essential information for insurance purposes, but they do not necessarily provide relevant information for non-insurance aspects of flood risk management (FRM such as public education and emergency planning. Recent calls for flood hazard maps that support a wider variety of FRM tasks highlight the need to deepen our understanding about the factors that make flood maps useful and understandable for local end users. In this study, social scientists and engineers explore opportunities for improving the utility and relevance of flood hazard maps through the co-production of maps responsive to end users' FRM needs. Specifically, two-dimensional flood modeling produced a set of baseline hazard maps for stakeholders of the Tijuana River valley, US, and Los Laureles Canyon in Tijuana, Mexico. Focus groups with natural resource managers, city planners, emergency managers, academia, non-profit, and community leaders refined the baseline hazard maps by triggering additional modeling scenarios and map revisions. Several important end user preferences emerged, such as (1 legends that frame flood intensity both qualitatively and quantitatively, and (2 flood scenario descriptions that report flood magnitude in terms of rainfall, streamflow, and its relation to an historic event. Regarding desired hazard map content, end users' requests revealed general consistency with mapping needs reported in European studies and guidelines published in Australia. However, requested map content that is not commonly produced included (1 standing water depths following the flood, (2 the erosive potential of flowing water, and (3 pluvial flood hazards, or flooding caused directly by rainfall. We conclude that the relevance and utility of commonly produced flood hazard maps can be most improved by illustrating

  9. Going beyond the flood insurance rate map: insights from flood hazard map co-production

    Science.gov (United States)

    Luke, Adam; Sanders, Brett F.; Goodrich, Kristen A.; Feldman, David L.; Boudreau, Danielle; Eguiarte, Ana; Serrano, Kimberly; Reyes, Abigail; Schubert, Jochen E.; AghaKouchak, Amir; Basolo, Victoria; Matthew, Richard A.

    2018-04-01

    Flood hazard mapping in the United States (US) is deeply tied to the National Flood Insurance Program (NFIP). Consequently, publicly available flood maps provide essential information for insurance purposes, but they do not necessarily provide relevant information for non-insurance aspects of flood risk management (FRM) such as public education and emergency planning. Recent calls for flood hazard maps that support a wider variety of FRM tasks highlight the need to deepen our understanding about the factors that make flood maps useful and understandable for local end users. In this study, social scientists and engineers explore opportunities for improving the utility and relevance of flood hazard maps through the co-production of maps responsive to end users' FRM needs. Specifically, two-dimensional flood modeling produced a set of baseline hazard maps for stakeholders of the Tijuana River valley, US, and Los Laureles Canyon in Tijuana, Mexico. Focus groups with natural resource managers, city planners, emergency managers, academia, non-profit, and community leaders refined the baseline hazard maps by triggering additional modeling scenarios and map revisions. Several important end user preferences emerged, such as (1) legends that frame flood intensity both qualitatively and quantitatively, and (2) flood scenario descriptions that report flood magnitude in terms of rainfall, streamflow, and its relation to an historic event. Regarding desired hazard map content, end users' requests revealed general consistency with mapping needs reported in European studies and guidelines published in Australia. However, requested map content that is not commonly produced included (1) standing water depths following the flood, (2) the erosive potential of flowing water, and (3) pluvial flood hazards, or flooding caused directly by rainfall. We conclude that the relevance and utility of commonly produced flood hazard maps can be most improved by illustrating pluvial flood hazards

  10. Mapping of wine industry

    Directory of Open Access Journals (Sweden)

    Віліна Пересадько

    2016-10-01

    Full Text Available Having reviewed a variety of approaches to understanding the essence of wine industry, having studied the modern ideas about the future of wine industry, having analyzed more than 50 maps from the Internet we have set the trends and special features of wine industry mapping in the world, such as: - the vast majority of maps displays the development of the industry at regional or national level, whereas there are practically no world maps; - wine-growing regions are represented on maps very unevenly; - all existing maps of the industry could be classified as analytical ascertaining inventory type; - the dominant ways of cartographic representation are area method and qualitative background method, sign method and collation maps are rarely used; - basically all the Internet maps have low quality as they are scanned images with poor resolution; - the special feature of maps published lately is lack of geographical basis (except for state borders and coastline. We created wine production and consumption world map «Wine Industry» in the scale of 1:60 000 000 with simple geographical basis (state names, state borders, major rivers, coastline. It was concluded that from the methodological point of view it is incorrect not to show geographical basis on maps of wine industry. Analysis of this map allowed us to identify areas of traditional wine-making, potential wine-making areas and countries which claim to be the world leaders in the field of wine production. We found disbalans between wine production and wine consumption - increasing wine production in South America, China and the United States and increasing wine consumption (mainly due to the import products in countries where the grape is not the primary agricultural product.

  11. Introduction to "Mapping Vietnameseness"

    OpenAIRE

    Hue-Tam Ho Tai

    2016-01-01

    Vietnam and China are currently engaged in a map war, with each country using ancient maps to buttress its claims to territorial sovereignty over some uninhabited islands in the South China Sea (in Chinese terminology), also known as the Eastern Sea (in Vietnamese). But what do maps in fact represent? What is meant by “territory”? How are territorial limits conceived? These questions were raised in a May 2015 workshop inspired by Thongchai Winichakul’s Siam Mapped: A History of the Geo-Body o...

  12. North America pipeline map

    International Nuclear Information System (INIS)

    Anon.

    2005-01-01

    This map presents details of pipelines currently in place throughout North America. Fifty-nine natural gas pipelines are presented, as well as 16 oil pipelines. The map also identifies six proposed natural gas pipelines. Major cities, roads and highways are included as well as state and provincial boundaries. The National Petroleum Reserve is identified, as well as the Arctic National Wildlife Refuge. The following companies placed advertisements on the map with details of the services they provide relating to pipeline management and construction: Ferus Gas Industries Trust; Proline; SulfaTreat Direct Oxidation; and TransGas. 1 map

  13. Open land use map

    OpenAIRE

    Mildorf, T.; Charvát, K.; Jezek, J.; Templer, Simon; Malewski, Christian

    2014-01-01

    Open Land Use Map is an initiative that has been started by the Plan4business project and that will be extended as part of the SDI4Apps project in the future. This service aims to create an improved worldwide land use map. The initial map will be prepared using the CORINE Land Cover, Global Cover dataset and Open Street Map. Contributors, mainly volunteers, will able to change the geometry and assign up-to-date land use according to the HILUCS specification. For certain regions more detailed ...

  14. Landslide susceptibility map: from research to application

    Science.gov (United States)

    Fiorucci, Federica; Reichenbach, Paola; Ardizzone, Francesca; Rossi, Mauro; Felicioni, Giulia; Antonini, Guendalina

    2014-05-01

    Susceptibility map is an important and essential tool in environmental planning, to evaluate landslide hazard and risk and for a correct and responsible management of the territory. Landslide susceptibility is the likelihood of a landslide occurring in an area on the basis of local terrain conditions. Can be expressed as the probability that any given region will be affected by landslides, i.e. an estimate of "where" landslides are likely to occur. In this work we present two examples of landslide susceptibility map prepared for the Umbria Region and for the Perugia Municipality. These two maps were realized following official request from the Regional and Municipal government to the Research Institute for the Hydrogeological Protection (CNR-IRPI). The susceptibility map prepared for the Umbria Region represents the development of previous agreements focused to prepare: i) a landslide inventory map that was included in the Urban Territorial Planning (PUT) and ii) a series of maps for the Regional Plan for Multi-risk Prevention. The activities carried out for the Umbria Region were focused to define and apply methods and techniques for landslide susceptibility zonation. Susceptibility maps were prepared exploiting a multivariate statistical model (linear discriminant analysis) for the five Civil Protection Alert Zones defined in the regional territory. The five resulting maps were tested and validated using the spatial distribution of recent landslide events that occurred in the region. The susceptibility map for the Perugia Municipality was prepared to be integrated as one of the cartographic product in the Municipal development plan (PRG - Piano Regolatore Generale) as required by the existing legislation. At strategic level, one of the main objectives of the PRG, is to establish a framework of knowledge and legal aspects for the management of geo-hydrological risk. At national level most of the susceptibility maps prepared for the PRG, were and still are obtained

  15. Suppression of inflammatory and infection responses in lung macrophages by eucalyptus oil and its constituent 1,8-cineole: Role of pattern recognition receptors TREM-1 and NLRP3, the MAP kinase regulator MKP-1, and NFκB.

    Directory of Open Access Journals (Sweden)

    Niket Yadav

    Full Text Available Eucalyptus oil (EO used in traditional medicine continues to prove useful for aroma therapy in respiratory ailments; however, there is a paucity of information on its mechanism of action and active components. In this direction, we investigated EO and its dominant constituent 1,8-cineole (eucalyptol using the murine lung alveolar macrophage (AM cell line MH-S. In an LPS-induced AM inflammation model, pre-treatment with EO significantly reduced (P ≤0.01or 0.05 the pro-inflammatory mediators TNF-α, IL-1 (α and β, and NO, albeit at a variable rate and extent; 1,8-cineole diminished IL-1 and IL-6. In a mycobacterial-infection AM model, EO pre-treatment or post-treatment significantly enhanced (P ≤0.01 the phagocytic activity and pathogen clearance. 1,8-cineole also significantly enhanced the pathogen clearance though the phagocytic activity was not significantly altered. EO or 1,8-cineole pre-treatment attenuated LPS-induced inflammatory signaling pathways at various levels accompanied by diminished inflammatory response. Among the pattern recognition receptors (PRRs involved in LPS signaling, the TREM pathway surface receptor (TREM-1 was significantly downregulated. Importantly, the pre-treatments significantly downregulated (P ≤0.01 the intracellular PRR receptor NLRP3 of the inflammasome, which is consistent with the decrease in IL-1β secretion. Of the shared downstream signaling cascade for these PRR pathways, there was significant attenuation of phosphorylation of the transcription factor NF-κB and p38 (but increased phosphorylation of the other two MAP kinases, ERK1/2 and JNK1/2. 1,8-cineole showed a similar general trend except for an opposite effect on NF-κB and JNK1/2. In this context, either pre-treatment caused a significant downregulation of MKP-1 phosphatase, a negative regulator of MAPKs. Collectively, our results demonstrate that the anti-inflammatory activity of EO and 1,8-cineole is modulated via selective downregulation

  16. On circle map coupled map lattice

    CERN Document Server

    Ahmed, E

    2002-01-01

    Circle map in one and two dimensions is studied. Both its stability, synchronization using bounded control and persistence is discussed. This work is expected to be applicable in ecology where spatial effects are known to be important. Also it will be relevant to systems where delay effects are not negligible.

  17. Spatiotemporal chaos in coupled logistic maps

    International Nuclear Information System (INIS)

    Varella Guedes, Andre; Amorim Savi, Marcelo

    2010-01-01

    The objective of this work is to investigate the spatiotemporal dynamics of coupled logistic maps. These maps are prototypes of high-dimensional dynamical systems and have been used to describe the evolution and pattern formation in different systems. Here, the logistic map lattice is coupled by a power law and, therefore, each map is influenced by other maps in its neighborhood. The Kolmogorov-Sinai entropy density is employed to quantify the complexity of system behavior, permitting a general qualitative understanding of different aspects of system dynamics. Three kinds of boundary conditions are treated and the influence of initial conditions is also of concern. Non-homogeneous maps are investigated, showing interesting aspects of spatiotemporal dynamics. The idea is to analyze the spatial interaction between two qualitative different types of behavior from a grid that is split into two parts. Numerical simulations show what types of conditions present a greater tendency to develop chaotic, periodic and synchronized responses. It should be highlighted that non-homogeneous grids have situations where a chaotic pattern can emerge from two periodic responses and also situations where a periodic pattern can emerge from chaos.

  18. Mapping online consumer search

    NARCIS (Netherlands)

    Bronnenberg, B.J.; Kim, J.; Albuquerque, P.

    2011-01-01

    The authors propose a new method to visualize browsing behavior in so-called product search maps. Manufacturers can use these maps to understand how consumers search for competing products before choice, including how information acquisition and product search are organized along brands, product

  19. Map of Nasca Geoglyphs

    Science.gov (United States)

    Hanzalová, K.; Pavelka, K.

    2013-07-01

    The Czech Technical University in Prague in the cooperation with the University of Applied Sciences in Dresden (Germany) work on the Nasca Project. The cooperation started in 2004 and much work has been done since then. All work is connected with Nasca lines in southern Peru. The Nasca project started in 1995 and its main target is documentation and conservation of the Nasca lines. Most of the project results are presented as WebGIS application via Internet. In the face of the impending destruction of the soil drawings, it is possible to preserve this world cultural heritage for the posterity at least in a digital form. Creating of Nasca lines map is very useful. The map is in a digital form and it is also available as a paper map. The map contains planimetric component of the map, map lettering and altimetry. Thematic folder in this map is a vector layer of the geoglyphs in Nasca/Peru. Basis for planimetry are georeferenced satellite images, altimetry is created from digital elevation model. This map was created in ArcGis software.

  20. Mapping of Outdoor Classrooms.

    Science.gov (United States)

    Horvath, Victor G.

    Mapping symbols adopted by the Michigan Department of Natural Resources are presented with their explanations. In an effort to provide standardization and familiarity teachers and other school people involved in an outdoor education program are encouraged to utilize the same symbols in constructing maps. (DK)

  1. MAP OF NASCA GEOGLYPHS

    Directory of Open Access Journals (Sweden)

    K. Hanzalová

    2013-07-01

    Full Text Available The Czech Technical University in Prague in the cooperation with the University of Applied Sciences in Dresden (Germany work on the Nasca Project. The cooperation started in 2004 and much work has been done since then. All work is connected with Nasca lines in southern Peru. The Nasca project started in 1995 and its main target is documentation and conservation of the Nasca lines. Most of the project results are presented as WebGIS application via Internet. In the face of the impending destruction of the soil drawings, it is possible to preserve this world cultural heritage for the posterity at least in a digital form. Creating of Nasca lines map is very useful. The map is in a digital form and it is also available as a paper map. The map contains planimetric component of the map, map lettering and altimetry. Thematic folder in this map is a vector layer of the geoglyphs in Nasca/Peru. Basis for planimetry are georeferenced satellite images, altimetry is created from digital elevation model. This map was created in ArcGis software.

  2. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Sporring, Jon; Fogh Olsen, Ole

    2008-01-01

    . To address this problem, we introduce a photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way, we preserve important illumination features, while...

  3. Maps between Grassmann manifolds

    Indian Academy of Sciences (India)

    Parameswaran Sankaran Institute of Mathematical Sciences Chennai, India sankaran@imsc.res.in Indian Academy of Sciences Platinum Jubilee Meeting Hyderabad

    2009-07-02

    Jul 2, 2009 ... Classification of all manifolds (or maps between them) is an impossible task. The coarser, homotopical classification, is relatively easier–but only relatively! Homotopy is, roughly speaking, the study of properties of spaces and maps invariant under continuous deformations. Denote by [X, Y ] the set of all ...

  4. Constructing Maps Collaboratively.

    Science.gov (United States)

    Leinhardt, Gaea; Stainton, Catherine; Bausmith, Jennifer Merriman

    1998-01-01

    Summarizes a study that maintains that students who work together in small groups had a better understanding of map concepts. Discusses why making maps in groups can enhance students' conceptual geographic understanding and offers suggestions for improving geography instructions using small group configurations. Includes statistical and graphic…

  5. Algorithms for necklace maps

    NARCIS (Netherlands)

    Speckmann, B.; Verbeek, K.A.B.

    2015-01-01

    Necklace maps visualize quantitative data associated with regions by placing scaled symbols, usually disks, without overlap on a closed curve (the necklace) surrounding the map regions. Each region is projected onto an interval on the necklace that contains its symbol. In this paper we address the

  6. Text 2 Mind Map

    OpenAIRE

    Iona, John

    2017-01-01

    This is a review of the web resource 'Text 2 Mind Map' www.Text2MindMap.com. It covers what the resource is, and how it might be used in Library and education context, in particular for School Librarians.

  7. Formal genetic maps

    African Journals Online (AJOL)

    Mohammad Saad Zaghloul Salem

    2014-12-24

    Dec 24, 2014 ... ome/transcriptome/proteome, experimental induced maps that are intentionally designed and con- ... genetic maps imposed their application in nearly all fields of medical genetics including ..... or genes located adjacent to, or near, them. ...... types of markers, e.g., clinical markers (eye color), genomic.

  8. USACE National Coastal Mapping Program Update

    Science.gov (United States)

    Sylvester, C.

    2017-12-01

    The Joint Airborne Lidar Bathymetry Technical Center of Expertise (JALBTCX) formed in 1998 to support the coastal mapping and charting requirements of the USACE, NAVO, NOAA and USGS. This partnership fielded three generations of airborne lidar bathymeters, executed operational data collection programs within the U.S. and overseas, and advanced research and development in airborne lidar bathymetry and complementary technologies. JALBTCX executes a USACE Headquarters-funded National Coastal Mapping Program (NCMP). Initiated in 2004, the NCMP provides high-resolution, high-accuracy elevation and imagery data along the sandy shorelines of the U.S. on a recurring basis. NCMP mapping activities are coordinated with Federal mapping partners through the Interagency Working Group on Ocean and Coastal Mapping and the 3D Elevation Program. The NCMP, currently in it's third cycle, is performing operations along the East Coast in 2017, after having completed surveys along the Gulf Coast in 2016 and conducting emergency response operations in support of Hurricane Matthew. This presentation will provide an overview of JALBTCX, its history in furthering airborne lidar bathymetry technology to meet emerging mapping requirements, current NCMP operations and data products, and Federal mapping coordination activities.

  9. International Map Year: Results and Implications

    Science.gov (United States)

    Rystedt, Bengt; Ormeling, Ferjan; Buckley, Aileen; Coetzee, Serena; Voženilek, Vit; Fairbairn, David; Kagawa, Ayako

    2018-05-01

    IMY was a worldwide celebration of maps and their unique role in our world. Supported by the United Nations, IMY provides opportunities to demonstrate, follow, and get involved in the art, science, and technology of making and using maps and geographic information. International Map Year (IMY) started in Paris 2011 when the General Assembly of the International Cartographic Association (ICA) asked the ICA Executive Committee (EC) to follow up on the proposal given in a motion from the Swedish Cartographic Society. An IMY Working Group (WG) was constituted - it defined the IMY goals and the activities required to reach them, and it proposed a suitable time period for the IMY to the ICA EC. IMY commenced in August 2015 and ended in December 2016. The success of IMY was dependent on all member nations of the ICA participating in an effort to broaden the knowledge of cartography and geographic information in society in general, especially among citizens and school children. Member nations of the ICA were responsible for organizing IMY activities, such as a national Map Day, through national IMY committees tasked to engage national organizations and spearheading collaboration. The IMY WG set up an IMY web site with general information on IMY, guidelines for how to organize Map Days, suggestions relating to activities aimed at general map awareness, and more. The web site also provides access to the electronic book The World of Maps, which has been translated from English into five other languages.

  10. Bodily maps of emotions.

    Science.gov (United States)

    Nummenmaa, Lauri; Glerean, Enrico; Hari, Riitta; Hietanen, Jari K

    2014-01-14

    Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In five experiments, participants (n = 701) were shown two silhouettes of bodies alongside emotional words, stories, movies, or facial expressions. They were asked to color the bodily regions whose activity they felt increasing or decreasing while viewing each stimulus. Different emotions were consistently associated with statistically separable bodily sensation maps across experiments. These maps were concordant across West European and East Asian samples. Statistical classifiers distinguished emotion-specific activation maps accurately, confirming independence of topographies across emotions. We propose that emotions are represented in the somatosensory system as culturally universal categorical somatotopic maps. Perception of these emotion-triggered bodily changes may play a key role in generating consciously felt emotions.

  11. Application of ecological mapping

    International Nuclear Information System (INIS)

    Sherk, J.A.

    1982-01-01

    The US Fish and Wildlife Service has initiated the production of a comprehensive ecological inventory map series for use as a major new planning tool. Important species data along with special land use designations are displayed on 1:250,000 scale topographic base maps. Sets of maps have been published for the Atlantic and Pacific coastal areas of the United States. Preparation of a map set for the Gulf of Mexico is underway at the present time. Potential application of ecological inventory map series information to a typical land disposal facility could occur during the narrowing of the number of possible disposal sites, the design of potential disposal site studies of ecological resources, the preparation of the environmental report, and the regulatory review of license applications. 3 figures, 3 tables

  12. The projective heat map

    CERN Document Server

    Schwartz, Richard Evan

    2017-01-01

    This book introduces a simple dynamical model for a planar heat map that is invariant under projective transformations. The map is defined by iterating a polygon map, where one starts with a finite planar N-gon and produces a new N-gon by a prescribed geometric construction. One of the appeals of the topic of this book is the simplicity of the construction that yet leads to deep and far reaching mathematics. To construct the projective heat map, the author modifies the classical affine invariant midpoint map, which takes a polygon to a new polygon whose vertices are the midpoints of the original. The author provides useful background which makes this book accessible to a beginning graduate student or advanced undergraduate as well as researchers approaching this subject from other fields of specialty. The book includes many illustrations, and there is also a companion computer program.

  13. A fruit quality gene map of Prunus

    Directory of Open Access Journals (Sweden)

    Bliss Fredrick A

    2009-12-01

    Full Text Available Abstract Background Prunus fruit development, growth, ripening, and senescence includes major biochemical and sensory changes in texture, color, and flavor. The genetic dissection of these complex processes has important applications in crop improvement, to facilitate maximizing and maintaining stone fruit quality from production and processing through to marketing and consumption. Here we present an integrated fruit quality gene map of Prunus containing 133 genes putatively involved in the determination of fruit texture, pigmentation, flavor, and chilling injury resistance. Results A genetic linkage map of 211 markers was constructed for an intraspecific peach (Prunus persica progeny population, Pop-DG, derived from a canning peach cultivar 'Dr. Davis' and a fresh market cultivar 'Georgia Belle'. The Pop-DG map covered 818 cM of the peach genome and included three morphological markers, 11 ripening candidate genes, 13 cold-responsive genes, 21 novel EST-SSRs from the ChillPeach database, 58 previously reported SSRs, 40 RAFs, 23 SRAPs, 14 IMAs, and 28 accessory markers from candidate gene amplification. The Pop-DG map was co-linear with the Prunus reference T × E map, with 39 SSR markers in common to align the maps. A further 158 markers were bin-mapped to the reference map: 59 ripening candidate genes, 50 cold-responsive genes, and 50 novel EST-SSRs from ChillPeach, with deduced locations in Pop-DG via comparative mapping. Several candidate genes and EST-SSRs co-located with previously reported major trait loci and quantitative trait loci for chilling injury symptoms in Pop-DG. Conclusion The candidate gene approach combined with bin-mapping and availability of a community-recognized reference genetic map provides an efficient means of locating genes of interest in a target genome. We highlight the co-localization of fruit quality candidate genes with previously reported fruit quality QTLs. The fruit quality gene map developed here is a

  14. Possibilities and methods for mapping air pollution

    Energy Technology Data Exchange (ETDEWEB)

    LeBlanc, F

    1971-01-01

    For various reasons lichens seem to be much more sensitive to air pollution than flowering plants. Various methods to map the long-range effect of phytotoxicants on epiphytic lichens and mosses have been proposed. This paper outlines a few of these and proposes a new method. In Sudbury, Ontario, vegetation has been greatly affected by sulfur dioxide emanating from three huge smelters. The author shows that his map based on the response of lichens matches quite well with another map from the same area based on continuous SO/sub 2/ monitoring. The advantage of the biological map is that it took two weeks to accumulate the data required while the other one took ten years.

  15. USGS Topo Base Map from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The USGS Topographic Base Map from The National Map. This tile cached web map service combines the most current data services (Boundaries, Names, Transportation,...

  16. Analyzing thematic maps and mapping for accuracy

    Science.gov (United States)

    Rosenfield, G.H.

    1982-01-01

    Two problems which exist while attempting to test the accuracy of thematic maps and mapping are: (1) evaluating the accuracy of thematic content, and (2) evaluating the effects of the variables on thematic mapping. Statistical analysis techniques are applicable to both these problems and include techniques for sampling the data and determining their accuracy. In addition, techniques for hypothesis testing, or inferential statistics, are used when comparing the effects of variables. A comprehensive and valid accuracy test of a classification project, such as thematic mapping from remotely sensed data, includes the following components of statistical analysis: (1) sample design, including the sample distribution, sample size, size of the sample unit, and sampling procedure; and (2) accuracy estimation, including estimation of the variance and confidence limits. Careful consideration must be given to the minimum sample size necessary to validate the accuracy of a given. classification category. The results of an accuracy test are presented in a contingency table sometimes called a classification error matrix. Usually the rows represent the interpretation, and the columns represent the verification. The diagonal elements represent the correct classifications. The remaining elements of the rows represent errors by commission, and the remaining elements of the columns represent the errors of omission. For tests of hypothesis that compare variables, the general practice has been to use only the diagonal elements from several related classification error matrices. These data are arranged in the form of another contingency table. The columns of the table represent the different variables being compared, such as different scales of mapping. The rows represent the blocking characteristics, such as the various categories of classification. The values in the cells of the tables might be the counts of correct classification or the binomial proportions of these counts divided by

  17. Color on emergency mapping

    Science.gov (United States)

    Jiang, Lili; Qi, Qingwen; Zhang, An

    2007-06-01

    There are so many emergency issues in our daily life. Such as typhoons, tsunamis, earthquake, fires, floods, epidemics, etc. These emergencies made people lose their lives and their belongings. Every day, every hour, even every minute people probably face the emergency, so how to handle it and how to decrease its hurt are the matters people care most. If we can map it exactly before or after the emergencies; it will be helpful to the emergency researchers and people who live in the emergency place. So , through the emergency map, before emergency is occurring we can predict the situation, such as when and where the emergency will be happen; where people can refuge, etc. After disaster, we can also easily assess the lost, discuss the cause and make the lost less. The primary effect of mapping is offering information to the people who care about the emergency and the researcher who want to study it. Mapping allows the viewers to get a spatial sense of hazard. It can also provide the clues to study the relationship of the phenomenon in emergency. Color, as the basic element of the map, it can simplify and clarify the phenomenon. Color can also affects the general perceptibility of the map, and elicits subjective reactions to the map. It is to say, structure, readability, and the reader's psychological reactions can be affected by the use of color.

  18. Cognitive maps and attention.

    Science.gov (United States)

    Hardt, Oliver; Nadel, Lynn

    2009-01-01

    Cognitive map theory suggested that exploring an environment and attending to a stimulus should lead to its integration into an allocentric environmental representation. We here report that directed attention in the form of exploration serves to gather information needed to determine an optimal spatial strategy, given task demands and characteristics of the environment. Attended environmental features may integrate into spatial representations if they meet the requirements of the optimal spatial strategy: when learning involves a cognitive mapping strategy, cues with high codability (e.g., concrete objects) will be incorporated into a map, but cues with low codability (e.g., abstract paintings) will not. However, instructions encouraging map learning can lead to the incorporation of cues with low codability. On the other hand, if spatial learning is not map-based, abstract cues can and will be used to encode locations. Since exploration appears to determine what strategy to apply and whether or not to encode a cue, recognition memory for environmental features is independent of whether or not a cue is part of a spatial representation. In fact, when abstract cues were used in a way that was not map-based, or when they were not used for spatial navigation at all, they were nevertheless recognized as familiar. Thus, the relation between exploratory activity on the one hand and spatial strategy and memory on the other appears more complex than initially suggested by cognitive map theory.

  19. Crowdsourcing The National Map

    Science.gov (United States)

    McCartney, Elizabeth; Craun, Kari J.; Korris, Erin M.; Brostuen, David A.; Moore, Laurence R.

    2015-01-01

    Using crowdsourcing techniques, the US Geological Survey’s (USGS) Volunteered Geographic Information (VGI) project known as “The National Map Corps (TNMCorps)” encourages citizen scientists to collect and edit data about man-made structures in an effort to provide accurate and authoritative map data for the USGS National Geospatial Program’s web-based The National Map. VGI is not new to the USGS, but past efforts have been hampered by available technologies. Building on lessons learned, TNMCorps volunteers are successfully editing 10 different structure types in all 50 states as well as Puerto Rico and the US Virgin Islands.

  20. Region & Gateway Mapping

    OpenAIRE

    Schröter, Derik

    2007-01-01

    State-of-the-art robot mapping approaches are capable of acquiring impressively accurate 2D and 3D models of their environments. To the best of our knowledge, few of them represent structure or acquire models of task-relevant objects. In this work, a new approach to mapping of indoor environments is presented, in which the environment structure in terms of regions and gateways is automatically extracted, while the robot explores. Objects, both in 2D and 3D, are modeled explicitly in those map...

  1. MUTYH Associated Polyposis (MAP)

    DEFF Research Database (Denmark)

    Poulsen, Marie Louise Mølgaard; Bisgaard, M L

    2008-01-01

    Adenomatous Polyposis (FAP) and to a lesser extend Lynch Syndrome, which are caused by germline mutations in the APC and Mismatch Repair (MMR) genes, respectively.Here we review research findings regarding MUTYH interactions, genotypic and phenotypic characteristics of MAP, as well as surveillance......MUTYH Associated Polyposis (MAP), a Polyposis predisposition caused by biallelic mutations in the Base Excision Repair (BER) gene MUTYH, confers a marked risk of colorectal cancer (CRC). The MAP phenotype is difficult to distinguish from other hereditary CRC syndromes. Especially from Familial...

  2. Elevation data for floodplain mapping

    National Research Council Canada - National Science Library

    Committee on Floodplain Mapping Technologies; National Research Council; Division on Earth and Life Studies; National Research Council

    2007-01-01

    .... Elevation Data for Floodplain Mapping shows that there is sufficient two-dimensional base map imagery to meet FEMA's flood map modernization goals, but that the three-dimensional base elevation data...

  3. Northern Hemisphere Synoptic Weather Maps

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Daily Series of Synoptic Weather Maps. Part I consists of plotted and analyzed daily maps of sea-level and 500-mb maps for 0300, 0400, 1200, 1230, 1300, and 1500...

  4. DOT Official County Highway Map

    Data.gov (United States)

    Minnesota Department of Natural Resources — The County Highway Map theme is a scanned and rectified version of the original MnDOT County Highway Map Series. The cultural features on some of these maps may be...

  5. Tools for mapping ecosystem services

    Science.gov (United States)

    Palomo, Ignacio; Adamescu, Mihai; Bagstad, Kenneth J.; Cazacu, Constantin; Klug, Hermann; Nedkov, Stoyan; Burkhard, Benjamin; Maes, Joachim

    2017-01-01

    Mapping tools have evolved impressively in recent decades. From early computerised mapping techniques to current cloud-based mapping approaches, we have witnessed a technological evolution that has facilitated the democratisation of Geographic Information

  6. Community asset mapping for violence prevention

    African Journals Online (AJOL)

    opperwjj

    Responses to this violence take many forms, including various violence prevention and ... 2 SCRATCHMAPS: Spiritual Capacity and Religious Assets for Transforming Community Health by Mobilising Males for Peace and. Safety .... The asset mapping methodology and toolset were designed by the collaborative research.

  7. Map Your Way to a Better Lab.

    Science.gov (United States)

    Roth, Wolff-Michael

    1990-01-01

    The use of concept maps, Vee diagrams, flow charts, and productive questions to increase student understanding of laboratory exercises and to improve student attitudes toward lab classes is discussed. Examples of each are provided. Student responses to these teaching methods are described. (CW)

  8. Reverberation Mapping Results from MDM Observatory

    DEFF Research Database (Denmark)

    Denney, Kelly D.; Peterson, B. M.; Pogge, R. W.

    2009-01-01

    We present results from a multi-month reverberation mapping campaign undertaken primarily at MDM Observatory with supporting observations from around the world. We measure broad line region (BLR) radii and black hole masses for six objects. A velocity-resolved analysis of the H_beta response show...

  9. Programming with Hierarchical Maps

    DEFF Research Database (Denmark)

    Ørbæk, Peter

    This report desribes the hierarchical maps used as a central data structure in the Corundum framework. We describe its most prominent features, ague for its usefulness and briefly describe some of the software prototypes implemented using the technology....

  10. Haz-Map

    Data.gov (United States)

    U.S. Department of Health & Human Services — Haz-Map is an occupational health database designed for health and safety professionals and for consumers seeking information about the adverse effects of workplace...

  11. TOXMAP®: Environmental Health Maps

    Data.gov (United States)

    U.S. Department of Health & Human Services — TOXMAP® is a Geographic Information System (GIS) that uses maps of the United States and Canada to help users visually explore data primarily from the EPA's Toxics...

  12. The CPD Maps System

    Data.gov (United States)

    Department of Housing and Urban Development — CPD Maps includes data on the locations of existing CDBG, HOME, public housing and other HUD-funded community assets, so that users can view past investments...

  13. MetaMap

    Data.gov (United States)

    U.S. Department of Health & Human Services — MetaMap is a highly configurable application developed by the Lister Hill National Center for Biomedical Communications at the National Library of Medicine (NLM) to...

  14. FLOODPLAIN MAPPING, Bandera, TEXAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  15. FLOODPLAIN MAPPING, Atascosa, TEXAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  16. Public Waters Inventory Maps

    Data.gov (United States)

    Minnesota Department of Natural Resources — This theme is a scanned and rectified version of the Minnesota DNR - Division of Waters "Public Waters Inventory" (PWI) maps. DNR Waters utilizes a small scale...

  17. Daily Weather Maps

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Several different government offices have published the Daily weather maps over its history. The publication has also gone by different names over time. The U.S....

  18. Mapping Intermediality in Performance

    NARCIS (Netherlands)

    2010-01-01

    Mapping Intermediality in Performance benadert het vraagstuk van intermedialiteit met betrekking tot performance (vooral theater) vanuit vijf verschillende invalshoeken: performativiteit en lichaam; tijd en ruimte; digitale cultuur en posthumanisme; netwerken; pedagogiek en praxis. In deze boeiende

  19. Mapping the HISS Dipole

    International Nuclear Information System (INIS)

    McParland, C.; Bieser, F.

    1984-01-01

    The principal component of the Bevalac HISS facility is a large super-conducting 3 Tesla dipole. The facility's need for a large magnetic volume spectrometer resulted in a large gap geometry - a 2 meter pole tip diameter and a 1 meter pole gap. Obviously, the field required detailed mapping for effective use as a spectrometer. The mapping device was designed with several major features in mind. The device would measure field values on a grid which described a closed rectangular solid. The grid would be a regular with the exact measurement intervals adjustable by software. The device would function unattended over the long period of time required to complete a field map. During this time, the progress of the map could be monitored by anyone with access to the HISS VAX computer. Details of the mechanical, electrical, and control design follow

  20. NOS Bathymetric Maps

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This collection of bathymetric contour maps which represent the seafloor topography includes over 400 individual titles and covers US offshore areas including Hawaii...

  1. Survey on Ontology Mapping

    Science.gov (United States)

    Zhu, Junwu

    To create a sharable semantic space in which the terms from different domain ontology or knowledge system, Ontology mapping become a hot research point in Semantic Web Community. In this paper, motivated factors of ontology mapping research are given firstly, and then 5 dominating theories and methods, such as information accessing technology, machine learning, linguistics, structure graph and similarity, are illustrated according their technology class. Before we analyses the new requirements and takes a long view, the contributions of these theories and methods are summarized in details. At last, this paper suggest to design a group of semantic connector with the ability of migration learning for OWL-2 extended with constrains and the ontology mapping theory of axiom, so as to provide a new methodology for ontology mapping.

  2. Interest rates mapping

    Science.gov (United States)

    Kanevski, M.; Maignan, M.; Pozdnoukhov, A.; Timonin, V.

    2008-06-01

    The present study deals with the analysis and mapping of Swiss franc interest rates. Interest rates depend on time and maturity, defining term structure of the interest rate curves (IRC). In the present study IRC are considered in a two-dimensional feature space-time and maturity. Exploratory data analysis includes a variety of tools widely used in econophysics and geostatistics. Geostatistical models and machine learning algorithms (multilayer perceptron and Support Vector Machines) were applied to produce interest rate maps. IR maps can be used for the visualisation and pattern perception purposes, to develop and to explore economical hypotheses, to produce dynamic asset-liability simulations and for financial risk assessments. The feasibility of an application of interest rates mapping approach for the IRC forecasting is considered as well.

  3. National Coastal Mapping Program

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — The U. S. Army Corps of Engineers (USACE) National Coastal Mapping Program (NCMP) is designed to provide high-resolution elevation and imagery data along U.S....

  4. BaseMap

    Data.gov (United States)

    California Natural Resource Agency — The goal of this project is to provide a convenient base map that can be used as a starting point for CA projects. It's simple, but designed to work at a number of...

  5. Stochasticity in the Josephson map

    International Nuclear Information System (INIS)

    Nomura, Y.; Ichikawa, Y.H.; Filippov, A.T.

    1996-04-01

    The Josephson map describes nonlinear dynamics of systems characterized by standard map with the uniform external bias superposed. The intricate structures of the phase space portrait of the Josephson map are examined on the basis of the tangent map associated with the Josephson map. Numerical observation of the stochastic diffusion in the Josephson map is examined in comparison with the renormalized diffusion coefficient calculated by the method of characteristic function. The global stochasticity of the Josephson map occurs at the values of far smaller stochastic parameter than the case of the standard map. (author)

  6. Ogallala Aquifer Mapping Program

    International Nuclear Information System (INIS)

    1984-10-01

    A computerized data file has been established which can be used efficiently by the contour-plotting program SURFACE II to produce maps of the Ogallala aquifer in 17 counties of the Texas Panhandle. The data collected have been evaluated and compiled into three sets, from which SURFACE II can generate maps of well control, aquifer thickness, saturated thickness, water level, and the difference between virgin (pre-1942) and recent (1979 to 1981) water levels. 29 figures, 1 table

  7. Maps for the future.

    Directory of Open Access Journals (Sweden)

    Cristina D’Alessandro-Scarpari

    2005-05-01

    Full Text Available Geographers’ relations with maps have a long story of attraction and repulsion. The map has always fascinated Geographers (even before the institutionalization of the discipline as a powerful tool, able to demarcate territories, to produce different visions of them and to transform them by the actions they may cause or influence. Sometimes for strategic reasons Geographers have also denigrated cartography as a secondary and technical form of knowledge, a tool merely for understanding and ...

  8. Dynamics of exponential maps

    OpenAIRE

    Rempe, Lasse

    2003-01-01

    This thesis contains several new results about the dynamics of exponential maps $z\\mapsto \\exp(z)+\\kappa$. In particular, we prove that periodic external rays of exponential maps with nonescaping singular value always land. This is an analog of a theorem of Douady and Hubbard for polynomials. We also answer a question of Herman, Baker and Rippon by showing that the boundary of an unbounded exponential Siegel disk always contains the singular value. In addition to the presentation of new resul...

  9. The National Map - Orthoimagery

    Science.gov (United States)

    Mauck, James; Brown, Kim; Carswell, William J.

    2009-01-01

    Orthorectified digital aerial photographs and satellite images of 1-meter (m) pixel resolution or finer make up the orthoimagery component of The National Map. The process of orthorectification removes feature displacements and scale variations caused by terrain relief and sensor geometry. The result is a combination of the image characteristics of an aerial photograph or satellite image and the geometric qualities of a map. These attributes allow users to: *Measure distance *Calculate areas *Determine shapes of features *Calculate directions *Determine accurate coordinates *Determine land cover and use *Perform change detection *Update maps The standard digital orthoimage is a 1-m or finer resolution, natural color or color infra-red product. Most are now produced as GeoTIFFs and accompanied by a Federal Geographic Data Committee (FGDC)-compliant metadata file. The primary source for 1-m data is the National Agriculture Imagery Program (NAIP) leaf-on imagery. The U.S. Geological Survey (USGS) utilizes NAIP imagery as the image layer on its 'Digital- Map' - a new generation of USGS topographic maps (http://nationalmap.gov/digital_map). However, many Federal, State, and local governments and organizations require finer resolutions to meet a myriad of needs. Most of these images are leaf-off, natural-color products at resolutions of 1-foot (ft) or finer.

  10. Climate Prediction Center - Forecasts & Outlook Maps, Graphs and Tables

    Science.gov (United States)

    Weather Service NWS logo - Click to go to the NWS home page Climate Prediction Center Home Site Map News list below The Climate Prediction Center (CPC) is responsible for issuing seasonal climate outlook maps , and National Centers for Environmental Prediction). These weather and climate products comprise the

  11. MAPS of Cancer

    Science.gov (United States)

    Gray, Lincoln

    1998-01-01

    Our goal was to produce an interactive visualization from a mathematical model that successfully predicts metastases from head and neck cancer. We met this goal early in the project. The visualization is available for the public to view. Our work appears to fill a need for more information about this deadly disease. The idea of this project was to make an easily interpretable visualization based on what we call "functional maps" of disease. A functional map is a graphic summary of medical data, where distances between parts of the body are determined by the probability of disease, not by anatomical distances. Functional maps often beat little resemblance to anatomical maps, but they can be used to predict the spread of disease. The idea of modeling the spread of disease in an abstract multidimensional space is difficult for many people. Our goal was to make the important predictions easy to see. NASA must face this problem frequently: how to help laypersons and professionals see important trends in abstract, complex data. We took advantage of concepts perfected in NASA's graphics libraries. As an analogy, consider a functional map of early America. Suppose we choose travel times, rather than miles, as our measures of inter-city distances. For Abraham Lincoln, travel times would have been the more meaningful measure of separation between cities. In such a map New Orleans would be close to Memphis because of the Mississippi River. St. Louis would be close to Portland because of the Oregon Trail. Oklahoma City would be far from Little Rock because of the Cheyenne. Such a map would look puzzling to those of us who have always seen physical maps, but the functional map would be more useful in predicting the probabilities of inter-site transit. Continuing the analogy, we could predict the spread of social diseases such as gambling along the rivers and cattle rustling along the trails. We could simply print the functional map of America, but it would be more interesting

  12. The National Map product and services directory

    Science.gov (United States)

    Newell, Mark R.

    2008-01-01

    As one of the cornerstones of the U.S. Geological Survey's (USGS) National Geospatial Program (NGP), The National Map is a collaborative effort among the USGS and other Federal, state, and local partners to improve and deliver topographic information for the Nation. It has many uses ranging from recreation to scientific analysis to emergency response. The National Map is easily accessible for display on the Web, as products, and as downloadable data. The geographic information available from The National Map includes orthoimagery (aerial photographs), elevation, geographic names, hydrography, boundaries, transportation, structures, and land cover. Other types of geographic information can be added to create specific types of maps. Of major importance, The National Map currently is being transformed to better serve the geospatial community. The USGS National Geospatial Program Office (NGPO) was established to provide leadership for placing geographic knowledge at the fingertips of the Nation. The office supports The National Map, Geospatial One-Stop (GOS), National Atlas of the United States®, and the Federal Geographic Data Committee (FGDC). This integrated portfolio of geospatial information and data supports the essential components of delivering the National Spatial Data Infrastructure (NSDI) and capitalizing on the power of place.

  13. Dynamic map labeling.

    Science.gov (United States)

    Been, Ken; Daiches, Eli; Yap, Chee

    2006-01-01

    We address the problem of filtering, selecting and placing labels on a dynamic map, which is characterized by continuous zooming and panning capabilities. This consists of two interrelated issues. The first is to avoid label popping and other artifacts that cause confusion and interrupt navigation, and the second is to label at interactive speed. In most formulations the static map labeling problem is NP-hard, and a fast approximation might have O(nlogn) complexity. Even this is too slow during interaction, when the number of labels shown can be several orders of magnitude less than the number in the map. In this paper we introduce a set of desiderata for "consistent" dynamic map labeling, which has qualities desirable for navigation. We develop a new framework for dynamic labeling that achieves the desiderata and allows for fast interactive display by moving all of the selection and placement decisions into the preprocessing phase. This framework is general enough to accommodate a variety of selection and placement algorithms. It does not appear possible to achieve our desiderata using previous frameworks. Prior to this paper, there were no formal models of dynamic maps or of dynamic labels; our paper introduces both. We formulate a general optimization problem for dynamic map labeling and give a solution to a simple version of the problem. The simple version is based on label priorities and a versatile and intuitive class of dynamic label placements we call "invariant point placements". Despite these restrictions, our approach gives a useful and practical solution. Our implementation is incorporated into the G-Vis system which is a full-detail dynamic map of the continental USA. This demo is available through any browser.

  14. Space mapping optimization algorithms for engineering design

    DEFF Research Database (Denmark)

    Koziel, Slawomir; Bandler, John W.; Madsen, Kaj

    2006-01-01

    A simple, efficient optimization algorithm based on space mapping (SM) is presented. It utilizes input SM to reduce the misalignment between the coarse and fine models of the optimized object over a region of interest, and output space mapping (OSM) to ensure matching of response and first...... to a benchmark problem. In comparison with SMIS, the models presented are simple and have a small number of parameters that need to be extracted. The new algorithm is applied to the optimization of coupled-line band-pass filter....

  15. Three-Dimensional Maps for Disaster Management

    Science.gov (United States)

    Bandrova, T.; Zlatanova, S.; Konecny, M.

    2012-07-01

    Geo-information techniques have proven their usefulness for the purposes of early warning and emergency response. These techniques enable us to generate extensive geo-information to make informed decisions in response to natural disasters that lead to better protection of citizens, reduce damage to property, improve the monitoring of these disasters, and facilitate estimates of the damages and losses resulting from them. The maintenance and accessibility of spatial information has improved enormously with the development of spatial data infrastructures (SDIs), especially with second-generation SDIs, in which the original product-based SDI was improved to a process-based SDI. Through the use of SDIs, geo-information is made available to local, national and international organisations in regions affected by natural disasters as well as to volunteers serving in these areas. Volunteer-based systems for information collection (e.g., Ushahidi) have been created worldwide. However, the use of 3D maps is still limited. This paper discusses the applicability of 3D geo-information to disaster management. We discuss some important aspects of maps for disaster management, such as user-centred maps, the necessary components for 3D maps, symbols, and colour schemas. In addition, digital representations are evaluated with respect to their visual controls, i.e., their usefulness for the navigation and exploration of the information. Our recommendations are based on responses from a variety of users of these technologies, including children, geospecialists and disaster managers from different countries.

  16. Introduction to "Mapping Vietnameseness"

    Directory of Open Access Journals (Sweden)

    Hue-Tam Ho Tai

    2016-09-01

    Full Text Available Vietnam and China are currently engaged in a map war, with each country using ancient maps to buttress its claims to territorial sovereignty over some uninhabited islands in the South China Sea (in Chinese terminology, also known as the Eastern Sea (in Vietnamese. But what do maps in fact represent? What is meant by “territory”? How are territorial limits conceived? These questions were raised in a May 2015 workshop inspired by Thongchai Winichakul’s Siam Mapped: A History of the Geo-Body of a Nation (1994, a groundbreaking book that traces the transformation of Thai geographical consciousness as a result of Siam’s encounter with Western powers in the nineteenth century. While many of Thongchai’s insights apply to the Vietnamese case, as the first of the three articles included in this special issue of Cross-Currents shows, some of the 2015 workshop participants’ conclusions departed from his, especially regarding the formation of a Vietnamese geographical consciousness before the colonial period.[i] This is true of the other two papers, which focus specifically on the construction of borders and the associated production of maps in the nineteenth century before French colonial conquest... Notes 1 Thanks are due to the Max Planck Institute for the Study of Religious and Ethnic Change in Gottingen, Germany, for its gracious hosting and generous funding of the conference, together with the Asia Center of Harvard University.

  17. Mapping sequences by parts

    Directory of Open Access Journals (Sweden)

    Guziolowski Carito

    2007-09-01

    Full Text Available Abstract Background: We present the N-map method, a pairwise and asymmetrical approach which allows us to compare sequences by taking into account evolutionary events that produce shuffled, reversed or repeated elements. Basically, the optimal N-map of a sequence s over a sequence t is the best way of partitioning the first sequence into N parts and placing them, possibly complementary reversed, over the second sequence in order to maximize the sum of their gapless alignment scores. Results: We introduce an algorithm computing an optimal N-map with time complexity O (|s| × |t| × N using O (|s| × |t| × N memory space. Among all the numbers of parts taken in a reasonable range, we select the value N for which the optimal N-map has the most significant score. To evaluate this significance, we study the empirical distributions of the scores of optimal N-maps and show that they can be approximated by normal distributions with a reasonable accuracy. We test the functionality of the approach over random sequences on which we apply artificial evolutionary events. Practical Application: The method is illustrated with four case studies of pairs of sequences involving non-standard evolutionary events.

  18. The evolving Alaska mapping program.

    Science.gov (United States)

    Brooks, P.D.; O'Brien, T. J.

    1986-01-01

    This paper describes the development of mapping in Alaska, the current status of the National Mapping Program, and future plans for expanding and improving the mapping coverage. Research projects with Landsat Multispectral Scanner and Return Vidicon imagery and real- and synthetic-aperture radar; image mapping programs; digital mapping; remote sensing projects; the Alaska National Interest Lands Conservation Act; and the Alaska High-Altitude Aerial Photography Program are also discussed.-from Authors

  19. Ergodicity of polygonal slap maps

    International Nuclear Information System (INIS)

    Del Magno, Gianluigi; Pedro Gaivão, José; Lopes Dias, João; Duarte, Pedro

    2014-01-01

    Polygonal slap maps are piecewise affine expanding maps of the interval obtained by projecting the sides of a polygon along their normals onto the perimeter of the polygon. These maps arise in the study of polygonal billiards with non-specular reflection laws. We study the absolutely continuous invariant probabilities (acips) of the slap maps for several polygons, including regular polygons and triangles. We also present a general method for constructing polygons with slap maps with more than one ergodic acip. (paper)

  20. Mapping Unknown Knowns

    DEFF Research Database (Denmark)

    Diogo de Andrade Silva, Elisa; Lanng, Ditte Bendix; Wind, Simon

    representative dimensions of travellers’ embodied ‘dwelling-in-motion’ (Urry, 2007) and experiences. The paper foregrounds a ‘Mapping-in-Motion’ graphic example, an experimental urban design student assignment aiming to map some of the less representative dimensions of journeys between A and B in Berlin...... in relation to analysis, representation, exploration and design of everyday travelling in the city. Such ‘mobilities design’ (Jensen and Lanng 2017) concerns routes, sites and artefacts of mobilities, e.g., road networks, train stations, and bike parking facilities. Some dimensions of these structures...

  1. Learning Bing maps API

    CERN Document Server

    Sinani, Artan

    2013-01-01

    This is a practical, hands-on guide with illustrative examples, which will help you explore the vast universe of Bing maps.If you are a developer who wants to learn how to exploit the numerous features of Bing Maps then this book is ideal for you. It can also be useful for more experienced developers who wish to explore other areas of the APIs. It is assumed that you have some knowledge of JavaScript, HTML, and CSS. For some chapters a working knowledge of .Net and Visual Studio is also needed.

  2. Graphene Conductance Uniformity Mapping

    DEFF Research Database (Denmark)

    Buron, Jonas Christian Due; Petersen, Dirch Hjorth; Bøggild, Peter

    2012-01-01

    We demonstrate a combination of micro four-point probe (M4PP) and non-contact terahertz time-domain spectroscopy (THz-TDS) measurements for centimeter scale quantitative mapping of the sheet conductance of large area chemical vapor deposited graphene films. Dual configuration M4PP measurements......, demonstrated on graphene for the first time, provide valuable statistical insight into the influence of microscale defects on the conductance, while THz-TDS has potential as a fast, non-contact metrology method for mapping of the spatially averaged nanoscopic conductance on wafer-scale graphene with scan times......, dominating the microscale conductance of the investigated graphene film....

  3. Using knowledge rules for pharmacy mapping.

    Science.gov (United States)

    Shakib, Shaun C; Che, Chengjian; Lau, Lee Min

    2006-01-01

    The 3M Health Information Systems (HIS) Healthcare Data Dictionary (HDD) is used to encode and structure patient medication data for the Electronic Health Record (EHR) of the Department of Defense's (DoD's) Armed Forces Health Longitudinal Technology Application (AHLTA). HDD Subject Matter Experts (SMEs) are responsible for initial and maintenance mapping of disparate, standalone medication master files from all 100 DoD host sites worldwide to a single concept-based vocabulary, to accomplish semantic interoperability. To achieve higher levels of automation, SMEs began defining a growing set of knowledge rules. These knowledge rules were implemented in a pharmacy mapping tool, which enhanced consistency through automation and increased mapping rate by 29%.

  4. Mapping and characterization of LCA networks

    DEFF Research Database (Denmark)

    Bjørn, Anders; Owsianiak, Mikolaj; Laurent, Alexis

    2013-01-01

    Purpose: The aims of this study were to provide an up-todate overview of global, regional and local networks supporting life cycle thinking and to characterize them according to their structure and activities. Methods: Following a tentative life cycle assessment (LCA) network definition, a mapping......: The provided list of LCA networks is currently the most comprehensive, publicly available mapping. We believe that the results of this mapping can serve as a basis for deciding where priorities should be set to increase the dissemination and development of LCA worldwide. In this aim, we also advocate...... was performed based on (1) a literature search, (2) a web search and (3) an inquiry to stakeholders distributed via the two largest LCA fora. Networks were characterized based on responses from a survey. Results and discussion: We identified 100 networks, of which 29 fulfilled all six criteria composing our...

  5. Mapping shape to visuomotor mapping: learning and generalisation of sensorimotor behaviour based on contextual information.

    Directory of Open Access Journals (Sweden)

    Loes C J van Dam

    2015-03-01

    Full Text Available Humans can learn and store multiple visuomotor mappings (dual-adaptation when feedback for each is provided alternately. Moreover, learned context cues associated with each mapping can be used to switch between the stored mappings. However, little is known about the associative learning between cue and required visuomotor mapping, and how learning generalises to novel but similar conditions. To investigate these questions, participants performed a rapid target-pointing task while we manipulated the offset between visual feedback and movement end-points. The visual feedback was presented with horizontal offsets of different amounts, dependent on the targets shape. Participants thus needed to use different visuomotor mappings between target location and required motor response depending on the target shape in order to "hit" it. The target shapes were taken from a continuous set of shapes, morphed between spiky and circular shapes. After training we tested participants performance, without feedback, on different target shapes that had not been learned previously. We compared two hypotheses. First, we hypothesised that participants could (explicitly extract the linear relationship between target shape and visuomotor mapping and generalise accordingly. Second, using previous findings of visuomotor learning, we developed a (implicit Bayesian learning model that predicts generalisation that is more consistent with categorisation (i.e. use one mapping or the other. The experimental results show that, although learning the associations requires explicit awareness of the cues' role, participants apply the mapping corresponding to the trained shape that is most similar to the current one, consistent with the Bayesian learning model. Furthermore, the Bayesian learning model predicts that learning should slow down with increased numbers of training pairs, which was confirmed by the present results. In short, we found a good correspondence between the

  6. Mapping the Views of Adolescent Health Stakeholders.

    Science.gov (United States)

    Ewan, Lindsay A; McLinden, Daniel; Biro, Frank; DeJonckheere, Melissa; Vaughn, Lisa M

    2016-01-01

    Health research that includes youth and family stakeholders increases the contextual relevance of findings, which can benefit both the researchers and stakeholders involved. The goal of this study was to identify youth and family adolescent health priorities and to explore strategies to address these concerns. Stakeholders identified important adolescent health concerns, perceptions of which were then explored using concept mapping. Concept mapping is a mixed-method participatory research approach that invites input from various stakeholders. In response to prompts, stakeholders suggested ways to address the identified health conditions. Adolescent participants then sorted the statements into groups based on content similarity and rated the statements for importance and feasibility. Multidimensional scaling and cluster analysis were then applied to create the concept maps. Stakeholders identified sexually transmitted infections (STIs) and obesity as the health conditions they considered most important. The concept map for STIs identified 7 clusters: General sex education, support and empowerment, testing and treatment, community involvement and awareness, prevention and protection, parental involvement in sex education, and media. The obesity concept map portrayed 8 clusters: Healthy food choices, obesity education, support systems, clinical and community involvement, community support for exercise, physical activity, nutrition support, and nutrition education. Ratings were generally higher for importance than for feasibility. The concept maps demonstrate stakeholder-driven ideas about approaches to target STIs and obesity in this context. Strategies at multiple social ecological levels were emphasized. The concept maps can be used to generate discussion regarding these topics and to identify interventions. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  7. 2004 Alaska Lidar Mapping

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data sets are generated using the OPTECH ALTM 70 kHz LIDAR system mounted onboard AeroMap's twin-engine Cessna 320 aircraft. Classified data sets such as this...

  8. Ramachandran and his Map

    Indian Academy of Sciences (India)

    Ramachandran map, detailed in this article. His current interests are peptide, cyclic peptide and protein conforma- tions, energetics, data analysis, computer modeling as well as development of new algorithms useful for the conformational studies. C Ramakrishnan. Introduction. Professor G N Ramachandran was one of the ...

  9. Photogrammetry and Digital Mapping

    DEFF Research Database (Denmark)

    Frederiksen, Poul

    1998-01-01

    Technical tour to Lithuania, Poland and Estonia for 13 technical staff and managers of State Land Service, HQ, Latvia. Focus on technical aspects and management of geographical data for map production and administration. Visits to state and local government organisations and newly established...

  10. Mapping World Hunger.

    Science.gov (United States)

    Van Vliet, Lucille W.

    1988-01-01

    Describes a lesson designed to involve students in grades 6 through 8 in learning how geography was affected the problem of world hunger. Emphasis is placed on using maps, globes, atlases, and geographic dictionaries, as well as books, magazines, and other resources. (MES)

  11. Fluence map segmentation

    International Nuclear Information System (INIS)

    Rosenwald, J.-C.

    2008-01-01

    The lecture addressed the following topics: 'Interpreting' the fluence map; The sequencer; Reasons for difference between desired and actual fluence map; Principle of 'Step and Shoot' segmentation; Large number of solutions for given fluence map; Optimizing 'step and shoot' segmentation; The interdigitation constraint; Main algorithms; Conclusions on segmentation algorithms (static mode); Optimizing intensity levels and monitor units; Sliding window sequencing; Synchronization to avoid the tongue-and-groove effect; Accounting for physical characteristics of MLC; Importance of corrections for leaf transmission and offset; Accounting for MLC mechanical constraints; The 'complexity' factor; Incorporating the sequencing into optimization algorithm; Data transfer to the treatment machine; Interface between R and V and accelerator; and Conclusions on fluence map segmentation (Segmentation is part of the overall inverse planning procedure; 'Step and Shoot' and 'Dynamic' options are available for most TPS (depending on accelerator model; The segmentation phase tends to come into the optimization loop; The physical characteristics of the MLC have a large influence on final dose distribution; The IMRT plans (MU and relative dose distribution) must be carefully validated). (P.A.)

  12. Mapping the Heavens

    Indian Academy of Sciences (India)

    results of astrophysical mapping along multi- ple dimensions of space and time that deter- mine the distribution ... discipline, the book evocatively charts out the enormous impact of these advances on human culture, in that our ... And her evocative writing skills make the de- scriptions of these various discoveries come alive.

  13. Bike Map Lines

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — Chapel Hill Bike Map Lines from KMZ file.This data came from the wiki comment board for the public, not an “official map” showing the Town of Chapel Hill's plans or...

  14. Copenhagen Sonic Experience Map

    DEFF Research Database (Denmark)

    Kreutzfeldt, Jacob

    2011-01-01

    In the wake of present European interest for mapping urban noise, it seems increasingly relevant to investigate the multiple ways in which sound intersects with the everyday experiences of urban citizens. Focusing on the polluting effects of infrastructural noise, the EU-initiated project of asse...

  15. Extending Lipschitz mappings continuously

    Czech Academy of Sciences Publication Activity Database

    Kopecká, Eva

    2012-01-01

    Roč. 18, č. 2 (2012), s. 167-177 ISSN 1425-6908 Institutional support: RVO:67985840 Keywords : Lipschitz mapping * Hilbert space * extension Subject RIV: BA - General Mathematics http://www.degruyter.com/view/j/jaa.2012.18.issue-2/jaa-2012-0011/jaa-2012-0011. xml

  16. STOCHASTIC FLOWS OF MAPPINGS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, the stochastic flow of mappings generated by a Feller convolution semigroup on a compact metric space is studied. This kind of flow is the generalization of superprocesses of stochastic flows and stochastic diffeomorphism induced by the strong solutions of stochastic differential equations.

  17. Mapping the Literature

    DEFF Research Database (Denmark)

    Boulus-Rødje, Nina

    2012-01-01

    As the utilization of various e-voting technologies has notably increased in the past few years, so has the amount of publications on experiences with these technologies. This article, will, therefore map the literature while highlighting some of the important topics discussed within the field of e...

  18. eMAPS

    CERN Document Server

    Human Resources Department

    2005-01-01

    Starting with the 2005 performance appraisal and advancement exercise (MAPS), the paper version of the annual appraisal report has been replaced by an electronic EDH version - eMAPS (see Weekly Bulletin 48/2004). As announced in Weekly Bulletin 2/2005, information sessions to explain the features of eMAPS using EDH have been arranged as follows: 18 January 2005: Main Auditorium (500-1-001) from 14:00 to 15:30. 20 January 2005: AB Auditorium II (864-1-D02) from 14:00 to 15:30. 24 January 2005: AT Auditorium (30-7-018) from 10:00 to 11:30. The changeover to an electronic appraisal report is designed to reduce the administrative workload involving, e.g. photocopying, tracing and filing paper copies, while allowing staff members and their hierarchy access to the report form at the appropriate times. There is no change in the procedure for the annual interview and the advancement exercise, though Administrative Circular No 26 (Rev. 5) has been updated to take account of the introduction of eMAPS. The content...

  19. Mapping functional connectivity

    Science.gov (United States)

    Peter Vogt; Joseph R. Ferrari; Todd R. Lookingbill; Robert H. Gardner; Kurt H. Riitters; Katarzyna Ostapowicz

    2009-01-01

    An objective and reliable assessment of wildlife movement is important in theoretical and applied ecology. The identification and mapping of landscape elements that may enhance functional connectivity is usually a subjective process based on visual interpretations of species movement patterns. New methods based on mathematical morphology provide a generic, flexible,...

  20. Historical Topographic Map Collection bookmark

    Science.gov (United States)

    Fishburn, Kristin A.; Allord, Gregory J.

    2017-06-29

    The U.S. Geological Survey (USGS) National Geospatial Program is scanning published USGS 1:250,000-scale and larger topographic maps printed between 1884, the inception of the topographic mapping program, and 2006. The goal of this project, which began publishing the historical scanned maps in 2011, is to provide a digital repository of USGS topographic maps, available to the public at no cost. For more than 125 years, USGS topographic maps have accurately portrayed the complex geography of the Nation. The USGS is the Nation’s largest producer of printed topographic maps, and prior to 2006, USGS topographic maps were created using traditional cartographic methods and printed using a lithographic printing process. As the USGS continues the release of a new generation of topographic maps (US Topo) in electronic form, the topographic map remains an indispensable tool for government, science, industry, land management planning, and leisure.

  1. 49 CFR 1152.13 - Amendment of the system diagram map or narrative.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Amendment of the system diagram map or narrative... map or narrative. (a) Each carrier shall be responsible for maintaining the continuing accuracy of its system diagram map and the accompanying line descriptions or narrative. Amendments may be filed at any...

  2. USGS Imagery Only Base Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — USGS Imagery Only is a tile cache base map of orthoimagery in The National Map visible to the 1:18,000 scale. Orthoimagery data are typically high resolution images...

  3. Contrasting water-use efficiency (WUE) responses of a potato mapping population and capability of modified ball-berry model to predict stomatal conductance and WUE measured at different environmental conditions

    DEFF Research Database (Denmark)

    Kaminski, Kacper Piotr; Kørup, Kirsten; Kristensen, K.

    2015-01-01

    Potatoes (Solanum tuberosum L.) are drought-sensitive and more efficient water use, while maintaining high yields is required. Here, water-use efficiency (WUE) of a mapping population comprising 144 clones from a cross between 90-HAF-01 (Solanum tuberosum1) and 90-HAG-15 (S. tuberosum2 × S....... sparsipilum) was measured on well-watered plants under controlled-environment conditions combining three levels of each of the factors: [CO2], temperature, light, and relative humidity in growth chambers. The clones were grouped according to their photosynthetic WUE (pWUE) and whole-plant WUE (wpWUE) during...... (34 %) and dry matter accumulation (55 %, P water use (16 %). The pWUE correlated negatively to the ratio between leaf-internal and leaf-external [CO2] (R2 = -0.86 in 2010 and R2 = -0.83 in 2011, P

  4. Airborne radiometric data - A tool for reconnaissance geological mapping using a GIS

    International Nuclear Information System (INIS)

    Graham, D.F.; Bonham-Carter, G.F.

    1993-01-01

    A clustering technique is applied to radioelement data, and the resulting cluster map is compared with a digitized geological map within a GIS software package. The cross tabulation clearly identifies those geological units that have a distinctive radioelement response. By reclassifying the map overlay and imposing a color coding scheme that enhances bedrock geology classes, the relationship between the bedrock geology and radioelement response is enhanced. The degree of correlation between the two cartographic images is site dependent, rather than global. Areas where the two maps differ indicate zones of possible interest for field verification of published field maps for the purposes of mineral exploration. 13 refs

  5. Maps help protect sensitive areas from spills : an integrated approach to environmental mapping

    International Nuclear Information System (INIS)

    Laflamme, A.; Leblanc, S.R.; Percy, R.J.

    2001-01-01

    The Atlantic Sensitivity Mapping Program (ASMP) is underway in Canada's Atlantic Region to develop and maintain the best possible sensitivity mapping system to provide planners and managers with the full range of information they would need in the event of a coastal oil spill drill or spill incident. This initiative also provides recommendations concerning resource protection at the time of a spill. ASMP has become a powerful tool, providing a consistent and standardized terminology throughout the range of spill planning, preparedness and real-time response activities. The desktop mapping system provides an easy-to-use approach for a wide range of technical and support data and information stored in various databases. The data and information are based on a consistent set of terms and definitions that describe the character of the shore zone, the objective and strategies for a specific response, and the methods for achieving those objectives. The data are linked with other resource information in a GIS-based system and can be updated quickly and easily as new information becomes available. The mapping program keeps evolving to better serve the needs of environmental emergency responders. In addition, all components will soon be integrated into a web-based mapping format for broader accessibility. Future work will focus on developing a pre-spill database for Labrador. 3 refs., 8 figs

  6. Letters of Map Change (LOMC)

    Data.gov (United States)

    Department of Homeland Security — Documents, including different types of Letters of MAP Revision (LOMR) and Letters of Map Amendment (LOMA), which are issued by FEMA to revise or amend the flood...

  7. NEPR Geographic Zone Map 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This geographic zone map was created by interpreting satellite and aerial imagery, seafloor topography (bathymetry model), and the new NEPR Benthic Habitat Map...

  8. NEPR Benthic Habitat Map 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This benthic habitat map was created from a semi-automated habitat mapping process, using a combination of bathymetry, satellite imagery, aerial imagery and...

  9. Map Usage in Virtual Environments

    National Research Council Canada - National Science Library

    Cevik, Helsin

    1998-01-01

    ... of map representation as an aid in performing navigation tasks. The approach taken was first to determine and then investigate the parameters that affect virtual map representation through an experiment designed specifically for this thesis...

  10. q-Deformed nonlinear maps

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 64; Issue 3 ... Keywords. Nonlinear dynamics; logistic map; -deformation; Tsallis statistics. ... As a specific example, a -deformation procedure is applied to the logistic map. Compared ...

  11. The Europa Global Geologic Map

    Science.gov (United States)

    Leonard, E. J.; Patthoff, D. A.; Senske, D. A.; Collins, G. C.

    2018-06-01

    The Europa Global Geologic Map reveals three periods in Europa's surface history as well as an interesting distribution of microchaos. We will discuss the mapping and the interesting implications of our analysis of Europa's surface.

  12. Map projections cartographic information systems

    CERN Document Server

    Grafarend, Erik W; Syffus, Rainer

    2014-01-01

    This book offers a timely review of map projections including sphere, ellipsoid, rotational surfaces, and geodetic datum transformations. Coverage includes computer vision, and remote sensing space projective mappings in photogrammetry.

  13. Map projections cartographic information systems

    CERN Document Server

    Grafarend, Erik W

    2006-01-01

    In the context of Geographical Information Systems (GIS) the book offers a timely review of map projections (sphere, ellipsoid, rotational surfaces) and geodetic datum transformations. For the needs of photogrammetry, computer vision, and remote sensing space projective mappings are reviewed.

  14. Universal map for cellular automata

    International Nuclear Information System (INIS)

    García-Morales, V.

    2012-01-01

    A universal map is derived for all deterministic 1D cellular automata (CAs) containing no freely adjustable parameters and valid for any alphabet size and any neighborhood range (including non-symmetrical neighborhoods). The map can be extended to an arbitrary number of dimensions and topologies and to arbitrary order in time. Specific CA maps for the famous Conway's Game of Life and Wolfram's 256 elementary CAs are given. An induction method for CAs, based in the universal map, allows mathematical expressions for the orbits of a wide variety of elementary CAs to be systematically derived. -- Highlights: ► A universal map is derived for all deterministic 1D cellular automata (CA). ► The map is generalized to 2D for Von Neumann, Moore and hexagonal neighborhoods. ► A map for all Wolfram's 256 elementary CAs is derived. ► A map for Conway's “Game of Life” is obtained.

  15. North America Synoptic Weather Maps

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Series of Synoptic Weather Maps. Maps contains a surface analysis comprised of plotted weather station observations, isobars indicating low and high-pressure...

  16. Associators in generalized octonionic maps

    International Nuclear Information System (INIS)

    Griffin, C.J.; Joshi, G.C.

    1994-01-01

    Generalizing previous work, it is shown that structural transitions are a general property of a large class of octonionic maps. They can thus be used as an indicator of non-associativity in an octonionic map. 7 refs., ills

  17. Mapping earthworm communities in Europe

    NARCIS (Netherlands)

    Rutgers, M.; Orgiazzi, A.; Gardi, C.; Römbke, J.; Jansch, S.; Keith, A.; Neilson, R.; Boag, B.; Schmidt, O.; Murchie, A.K.; Blackshaw, R.P.; Pérès, G.; Cluzeau, D.; Guernion, M.; Briones, M.J.I.; Rodeiro, J.; Pineiro, R.; Diaz Cosin, D.J.; Sousa, J.P.; Suhadolc, M.; Kos, I.; Krogh, P.H.; Faber, J.H.; Mulder, C.; Bogte, J.J.; Wijnen, van H.J.; Schouten, A.J.; Zwart, de D.

    2016-01-01

    Existing data sets on earthworm communities in Europe were collected, harmonized, collated, modelled and depicted on a soil biodiversity map. Digital Soil Mapping was applied using multiple regressions relating relatively low density earthworm community data to soil characteristics, land use,

  18. Map Usage in Virtual Environments

    National Research Council Canada - National Science Library

    Cevik, Helsin

    1998-01-01

    .... Instead, we can determine the parameters that affect virtual map representation and that help to construct a mental map, and then manipulate these parameters in order to increase the effectiveness...

  19. Mapping Deviant Democracy

    DEFF Research Database (Denmark)

    Seeberg, Michael

    2014-01-01

    A number of countries have emerged as stable (though minimalist) democracies despite low levels of modernization, lack of democratic neighbouring countries and other factors consistently related to democratic stability in the literature. The study of these deviant democracies is a promising new...... research field but it is afflicted by a notable problem, viz. the lack of a consensus as to which countries are actually instances of deviant democracy. The present article attempts to solve this problem by carrying out a comprehensive mapping of deviant democracies. First, I review the existing literature...... to provide an overview of the cases most often identified as deviant democracies. Second, I use a large-N analysis to systematically map deviant democracies. The analysis includes 159 countries covering the time period 1993–2008. The analysis points to 12 cases that merits further attention, viz...

  20. MAPS Appraisal Report Form

    CERN Multimedia

    HR Department

    2005-01-01

    As announced in Weekly Bulletin 48/2004, from now onwards, the paper MAPS appraisal report form has been replaced by an electronic form, which is available via EDH (on the EDH desktop under Other Tasks / HR & Training) No changes have been made to the contents of the form. Practical information will be available on the web page http://cern.ch/ais/projs/forms/maps/info.htm, and information meetings will be held on the following dates: 18 January 2005: MAIN AUDITORIUM (500-1-001) from 14:00 to 15:30. 20 January 2005: AB AUDITORIUM II (864-1-D02) from14:00 to 15:30. 24 January 2005: AT AUDITORIUM (30-7-018) from 10:00 to 11:30. Human Resources Department Tel. 73566

  1. Graphene mobility mapping

    DEFF Research Database (Denmark)

    Buron, Jonas Christian Due; Pizzocchero, Filippo; Jepsen, Peter Uhd

    2015-01-01

    Carrier mobility and chemical doping level are essential figures of merit for graphene, and large-scale characterization of these properties and their uniformity is a prerequisite for commercialization of graphene for electronics and electrodes. However, existing mapping techniques cannot directly...... assess these vital parameters in a non-destructive way. By deconvoluting carrier mobility and density from non-contact terahertz spectroscopic measurements of conductance in graphene samples with terahertz-transparent backgates, we are able to present maps of the spatial variation of both quantities over...... graphene indicates dominance by charged scatterers. Unexpectedly, significant variations in mobility rather than doping are the cause of large conductance inhomogeneities, highlighting the importance of statistical approaches when assessing large-area graphene transport properties....

  2. Mixed Map Labeling

    Directory of Open Access Journals (Sweden)

    Maarten Löffler

    2016-12-01

    Full Text Available Point feature map labeling is a geometric visualization problem, in which a set of input points must be labeled with a set of disjoint rectangles (the bounding boxes of the label texts. It is predominantly motivated by label placement in maps but it also has other visualization applications. Typically, labeling models either use internal labels, which must touch their feature point, or external (boundary labels, which are placed outside the input image and which are connected to their feature points by crossing-free leader lines. In this paper we study polynomial-time algorithms for maximizing the number of internal labels in a mixed labeling model that combines internal and external labels. The model requires that all leaders are parallel to a given orientation θ ∈ [0, 2π, the value of which influences the geometric properties and hence the running times of our algorithms.

  3. A meiotic linkage map of the silver fox, aligned and compared to the canine genome

    OpenAIRE

    Kukekova, Anna V.; Trut, Lyudmila N.; Oskina, Irina N.; Johnson, Jennifer L.; Temnykh, Svetlana V.; Kharlamova, Anastasiya V.; Shepeleva, Darya V.; Gulievich, Rimma G.; Shikhevich, Svetlana G.; Graphodatsky, Alexander S.; Aguirre, Gustavo D.; Acland, Gregory M.

    2007-01-01

    A meiotic linkage map is essential for mapping traits of interest and is often the first step toward understanding a cryptic genome. Specific strains of silver fox (a variant of the red fox, Vulpes vulpes), which segregate behavioral and morphological phenotypes, create a need for such a map. One such strain, selected for docility, exhibits friendly dog-like responses to humans, in contrast to another strain selected for aggression. Development of a fox map is facilitated by the known cytogen...

  4. Mapping Homophobia in Australia

    OpenAIRE

    Flood, Michael Gaston; Flood, Michael; Flood, C.; Hamilton, Clive

    2008-01-01

    One-third of the Australian population believe that 'homosexuality is immoral', and this belief is spread in distinct ways across the nation. Using data from a survey of nearly 25,000 Australians, we can 'map' homophobia in Australia. Homophobic attitudes are worst in country areas of Queensland and Tasmania. Men are far more likely than women to feel that homosexuality does not have moral legitimacy, and this gender gap in attitudes persists across age, socioeconomic, educational, and region...

  5. Intercreativity: Mapping Online Activism

    Science.gov (United States)

    Meikle, Graham

    How do activists use the Internet? This article maps a wide range of activist practice and research by applying and developing Tim Berners-Lee's concept of ‘intercreativity' (1999). It identifies four dimensions of Net activism: intercreative texts, tactics, strategies and networks. It develops these through examples of manifestations of Net activism around one cluster of issues: support campaigns for refugees and asylum seekers.

  6. MAP user's manual copyright

    International Nuclear Information System (INIS)

    Pillsbury, R.D. Jr.

    1991-12-01

    The program MITMAP represents a set of general purpose, two- dimensional, finite element programs for the calculation of magnetic fields. It consists of the program MAP and MAP2DJ. The two programs are used to solve different electromagnetic problems, but they have a common set of subrountines for pre- and postprocessing. Originally separate programs, they have been combined to make modification easier. The manuals, however, will remain separate. The program MAP is described in this manual. MAP is applicable to the class of problems with two-dimensional-planar or axisymmetric - geometries, in which the current density and the magnetic vector potential have only a single nonvanishing component. The single component is associated with the direction that is perpendicular to the plane of the problem and is invariant with respect to that direction. Maxwell's equations can be reduced to a solver diffusion equation in terms of the single, nonvanishing component of the magnetic vector potential for planar problems and to a single component of a vector potential for planar problems and to a single component of a vector diffusion equation for axisymmetric problems. The magnetic permeability appears in the governing equation. The permeability may be a function of the magnetic flux density. In addition, any electrically conducting material present will have eddy currents induced by a time varying magnetic field. These eddy currents must be included in the solution process. This manual provides a description of the structure of the input data and output for the program. There are several example problems presented that illustrate the major program features. Appendices are included that contain a derivation of the governing equations and the application of the finite element method to the solution of the equations

  7. Algebraic entropy for algebraic maps

    International Nuclear Information System (INIS)

    Hone, A N W; Ragnisco, Orlando; Zullo, Federico

    2016-01-01

    We propose an extension of the concept of algebraic entropy, as introduced by Bellon and Viallet for rational maps, to algebraic maps (or correspondences) of a certain kind. The corresponding entropy is an index of the complexity of the map. The definition inherits the basic properties from the definition of entropy for rational maps. We give an example with positive entropy, as well as two examples taken from the theory of Bäcklund transformations. (letter)

  8. Mind mapping in qualitative research.

    Science.gov (United States)

    Tattersall, Christopher; Powell, Julia; Stroud, James; Pringle, Jan

    We tested a theory that mind mapping could be used as a tool in qualitative research to transcribe and analyse an interview. We compared results derived from mind mapping with those from interpretive phenomenological analysis by examining patients' and carers' perceptions of a new nurse-led service. Mind mapping could be used to rapidly analyse simple qualitative audio-recorded interviews. More research is needed to establish the extent to which mind mapping can assist qualitative researchers.

  9. Fermion to boson mappings revisited

    International Nuclear Information System (INIS)

    Ginocchio, J.N.; Johnson, C.W.

    1996-01-01

    We briefly review various mappings of fermion pairs to bosons, including those based on mapping operators, such as Belyaev-Zelevinskii, and those on mapping states, such as Marumori; in particular we consider the work of Otsuka-Arima-Iachello, aimed at deriving the Interacting Boson Model. We then give a rigorous and unified description of state-mapping procedures which allows one to systematically go beyond Otsuka-Arima-Iachello and related approaches, along with several exact results. (orig.)

  10. System of automated map design

    International Nuclear Information System (INIS)

    Ponomarjov, S.Yu.; Rybalko, S.I.; Proskura, N.I.

    1992-01-01

    Preprint 'System of automated map design' contains information about the program shell for construction of territory map, performing level line drawing of arbitrary two-dimension field (in particular, the radionuclide concentration field). The work schedule and data structures are supplied, as well as data on system performance. The preprint can become useful for experts in radioecology and for all persons involved in territory pollution mapping or multi-purpose geochemical mapping. (author)

  11. Mapping in inertial frames

    International Nuclear Information System (INIS)

    Arunasalam, V.

    1989-05-01

    World space mapping in inertial frames is used to examine the Lorentz covariance of symmetry operations. It is found that the Galilean invariant concepts of simultaneity (S), parity (P), and time reversal symmetry (T) are not Lorentz covariant concepts for inertial observers. That is, just as the concept of simultaneity has no significance independent of the Lorentz inertial frame, likewise so are the concepts of parity and time reversal. However, the world parity (W) [i.e., the space-time reversal symmetry (P-T)] is a truly Lorentz covariant concept. Indeed, it is shown that only those mapping matrices M that commute with the Lorentz transformation matrix L (i.e., [M,L] = 0) are the ones that correspond to manifestly Lorentz covariant operations. This result is in accordance with the spirit of the world space Mach's principle. Since the Lorentz transformation is an orthogonal transformation while the Galilean transformation is not an orthogonal transformation, the formal relativistic space-time mapping theory used here does not have a corresponding non-relativistic counterpart. 12 refs

  12. Lectures on quasiconformal mappings

    CERN Document Server

    Ahlfors, Lars V

    2006-01-01

    Lars Ahlfors's Lectures on Quasiconformal Mappings, based on a course he gave at Harvard University in the spring term of 1964, was first published in 1966 and was soon recognized as the classic it was shortly destined to become. These lectures develop the theory of quasiconformal mappings from scratch, give a self-contained treatment of the Beltrami equation, and cover the basic properties of Teichm�ller spaces, including the Bers embedding and the Teichm�ller curve. It is remarkable how Ahlfors goes straight to the heart of the matter, presenting major results with a minimum set of prerequisites. Many graduate students and other mathematicians have learned the foundations of the theories of quasiconformal mappings and Teichm�ller spaces from these lecture notes. This edition includes three new chapters. The first, written by Earle and Kra, describes further developments in the theory of Teichm�ller spaces and provides many references to the vast literature on Teichm�ller spaces and quasiconformal ...

  13. Using Playground Maps for Movement

    Science.gov (United States)

    Colvin, A. Vonnie

    2016-01-01

    Many schools now decorate their outside hard surface areas with maps. These maps provide color and excitement to a playground and are a terrific teaching tool for geography. But these maps can easily be integrated into physical education as well to promote both physical activity as well as knowledge of geography. The purpose of this article is to…

  14. Drawing subway maps : a survey

    NARCIS (Netherlands)

    Wolff, A.

    2007-01-01

    This paper deals with automating the drawing of subway maps. There are two features of schematic subway maps that make them different from drawings of other networks such as flow charts or organigrams. First, most schematic subway maps use not only horizontal and vertical lines, but also diagonals.

  15. Genetic algorithms for map labeling

    NARCIS (Netherlands)

    Dijk, Steven Ferdinand van

    2001-01-01

    Map labeling is the cartographic problem of placing the names of features (for example cities or rivers) on the map. A good labeling has no intersections between labels. Even basic versions of the problem are NP-hard. In addition, realistic map-labeling problems deal with many cartographic

  16. Try This: Collaborative Mind Mapping

    Science.gov (United States)

    Mendelson, Melissa

    2016-01-01

    In this "Try This" article, students learn about collaborative mind mapping. A mind map is a type of graphic organizer that allows for short ideas to be written and linked to related ideas on a "map." A central idea is placed in the middle of the paper with related ideas connected to the central idea as well as to other ideas.…

  17. Advanced Map For Real-Time Process Control

    Science.gov (United States)

    Shiobara, Yasuhisa; Matsudaira, Takayuki; Sashida, Yoshio; Chikuma, Makoto

    1987-10-01

    MAP, a communications protocol for factory automation proposed by General Motors [1], has been accepted by users throughout the world and is rapidly becoming a user standard. In fact, it is now a LAN standard for factory automation. MAP is intended to interconnect different devices, such as computers and programmable devices, made by different manufacturers, enabling them to exchange information. It is based on the OSI intercomputer com-munications protocol standard under development by the ISO. With progress and standardization, MAP is being investigated for application to process control fields other than factory automation [2]. The transmission response time of the network system and centralized management of data exchanged with various devices for distributed control are import-ant in the case of a real-time process control with programmable controllers, computers, and instruments connected to a LAN system. MAP/EPA and MINI MAP aim at reduced overhead in protocol processing and enhanced transmission response. If applied to real-time process control, a protocol based on point-to-point and request-response transactions limits throughput and transmission response. This paper describes an advanced MAP LAN system applied to real-time process control by adding a new data transmission control that performs multicasting communication voluntarily and periodically in the priority order of data to be exchanged.

  18. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial

    NARCIS (Netherlands)

    Marina, Neyssa M.; Smeland, Sigbjørn; Bielack, Stefan S.; Bernstein, Mark; Jovic, Gordana; Krailo, Mark D.; Hook, Jane M.; Arndt, Carola; van den Berg, Henk; Brennan, Bernadette; Brichard, Bénédicte; Brown, Ken L. B.; Butterfass-Bahloul, Trude; Calaminus, Gabriele; Daldrup-Link, Heike E.; Eriksson, Mikael; Gebhardt, Mark C.; Gelderblom, Hans; Gerss, Joachim; Goldsby, Robert; Goorin, Allen; Gorlick, Richard; Grier, Holcombe E.; Hale, Juliet P.; Hall, Kirsten Sundby; Hardes, Jendrik; Hawkins, Douglas S.; Helmke, Knut; Hogendoorn, Pancras C. W.; Isakoff, Michael S.; Janeway, Katherine A.; Jürgens, Heribert; Kager, Leo; Kühne, Thomas; Lau, Ching C.; Leavey, Patrick J.; Lessnick, Stephen L.; Mascarenhas, Leo; Meyers, Paul A.; Mottl, Hubert; Nathrath, Michaela; Papai, Zsuzsanna; Randall, R. Lor; Reichardt, Peter; Renard, Marleen; Safwat, Akmal Ahmed; Schwartz, Cindy L.; Stevens, Michael C. G.; Strauss, Sandra J.; Teot, Lisa; Werner, Mathias; Sydes, Matthew R.; Whelan, Jeremy S.

    2016-01-01

    We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. EURAMOS-1 was an open-label,

  19. Modeling mechanisms of susceptibility in vitro: Differential activation of the MAP kinase ERK, but not p38, mediates variability and adaptation in the pro-inflammatory response to ozone

    Science.gov (United States)

    Ozone is a ubiquitous ambient air pollutant that causes pulmonary inflammation upon exposure. The ozone-induced inflammatory response varies by orders of magnitude and the range of variation in “healthy” individuals extends beyond that of “susceptible” po...

  20. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOSan open-label, international, randomised controlled trial-1): an open-label, international, randomised controlled trial

    DEFF Research Database (Denmark)

    Marina, Neyssa M; Smeland, Sigbjørn; Bielack, Stefan S

    2016-01-01

    BACKGROUND: We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. METHODS: EURAMOS-1 wa...

  1. Timed bisimulation and open maps

    DEFF Research Database (Denmark)

    Hune, Thomas; Nielsen, Mogens

    1998-01-01

    of timed bisimulation. Thus the abstract results from the theory of open maps apply, e.g. the existence of canonical models and characteristic logics. Here, we provide an alternative proof of decidability of bisimulation for finite timed transition systems in terms of open maps, and illustrate the use......Open maps have been used for defining bisimulations for a range of models, but none of these have modelled real-time. We define a category of timed transition systems, and use the general framework of open maps to obtain a notion of bisimulation. We show this to be equivalent to the standard notion...... of open maps in presenting bisimulations....

  2. A guide of patent map

    International Nuclear Information System (INIS)

    1999-12-01

    This book introduces application and characteristic of patent information, types of patent information data and research of patent information, arrangement of patent information and patent map, analysis of patent information, necessity, writing period arrangement way of patent map, cases of patent map on selection of task of research and development, system of research and development and application, examples of PM such as MAP by year, application, technique, Inventor, and claim point map and computerization like data arrangement of PM patent, collection of analysis range and item analysis of patent, cases and written reports on patent analysis.

  3. Proportional Symbol Mapping in R

    Directory of Open Access Journals (Sweden)

    Susumu Tanimura

    2006-01-01

    Full Text Available Visualization of spatial data on a map aids not only in data exploration but also in communication to impart spatial conception or ideas to others. Although recent carto-graphic functions in R are rapidly becoming richer, proportional symbol mapping, which is one of the common mapping approaches, has not been packaged thus far. Based on the theories of proportional symbol mapping developed in cartography, the authors developed some functions for proportional symbol mapping using R, including mathematical and perceptual scaling. An example of these functions demonstrated the new expressive power and options available in R, particularly for the visualization of conceptual point data.

  4. Derivation of the dipole map

    International Nuclear Information System (INIS)

    Ali, Halima; Punjabi, Alkesh; Boozer, Allen

    2004-01-01

    In our method of maps [Punjabi et al., Phy. Rev. Lett. 69, 3322 (1992), and Punjabi et al., J. Plasma Phys. 52, 91 (1994)], symplectic maps are used to calculate the trajectories of magnetic field lines in divertor tokamaks. Effects of the magnetic perturbations are calculated using the low MN map [Ali et al., Phys. Plasmas 11, 1908 (2004)] and the dipole map [Punjabi et al., Phys. Plasmas 10, 3992 (2003)]. The dipole map is used to calculate the effects of externally located current carrying coils on the trajectories of the field lines, the stochastic layer, the magnetic footprint, and the heat load distribution on the collector plates in divertor tokamaks [Punjabi et al., Phys. Plasmas 10, 3992 (2003)]. Symplectic maps are general, efficient, and preserve and respect the Hamiltonian nature of the dynamics. In this brief communication, a rigorous mathematical derivation of the dipole map is given

  5. Looking for an old map

    Science.gov (United States)

    ,

    1996-01-01

    Many people want maps that show an area of the United States as it existed many years ago. These are called historical maps, and there are two types. The most common type consists of special maps prepared by commercial firms to show such historical features as battle-fields, military routes, or the paths taken by famous travelers. Typically, these maps are for sale to tourists at the sites of historical events. The other type is the truly old map--one compiled by a surveyor or cartographer many years ago. Lewis and Clark, for example, made maps of their journeys into the Northwest Territories in 1803-6, and originals of some of these maps still exist.

  6. Conceptual maps as evaluation strategy

    Directory of Open Access Journals (Sweden)

    Dionísio Borsato

    2007-03-01

    Full Text Available The following work shows the conceptual map as an evaluation tool. In this study, an opening text was used as a previous organizer, with a theme related to the students’ daily lives. The developed activity consisted in elaborating conceptual maps before and after the experimental works. The evaluation was applied to 21 students of the 1st grade and 22 of the 3rd grade of High School. The elaborated maps were scored according to hierarchy, propositions, linking words, cross linking and examples. The classification of the maps elaborated before and after the experimental activity, was obtained having as a parameter, a referential conceptual map. In this classification many differences were observed between the first and second maps of both grades and among the groups. The elaboration of conceptual maps showed great potential as evaluation resources.

  7. Radiation Source Mapping with Bayesian Inverse Methods

    Science.gov (United States)

    Hykes, Joshua Michael

    We present a method to map the spectral and spatial distributions of radioactive sources using a small number of detectors. Locating and identifying radioactive materials is important for border monitoring, accounting for special nuclear material in processing facilities, and in clean-up operations. Most methods to analyze these problems make restrictive assumptions about the distribution of the source. In contrast, the source-mapping method presented here allows an arbitrary three-dimensional distribution in space and a flexible group and gamma peak distribution in energy. To apply the method, the system's geometry and materials must be known. A probabilistic Bayesian approach is used to solve the resulting inverse problem (IP) since the system of equations is ill-posed. The probabilistic approach also provides estimates of the confidence in the final source map prediction. A set of adjoint flux, discrete ordinates solutions, obtained in this work by the Denovo code, are required to efficiently compute detector responses from a candidate source distribution. These adjoint fluxes are then used to form the linear model to map the state space to the response space. The test for the method is simultaneously locating a set of 137Cs and 60Co gamma sources in an empty room. This test problem is solved using synthetic measurements generated by a Monte Carlo (MCNP) model and using experimental measurements that we collected for this purpose. With the synthetic data, the predicted source distributions identified the locations of the sources to within tens of centimeters, in a room with an approximately four-by-four meter floor plan. Most of the predicted source intensities were within a factor of ten of their true value. The chi-square value of the predicted source was within a factor of five from the expected value based on the number of measurements employed. With a favorable uniform initial guess, the predicted source map was nearly identical to the true distribution

  8. Online Exhibits & Concept Maps

    Science.gov (United States)

    Douma, M.

    2009-12-01

    Presenting the complexity of geosciences to the public via the Internet poses a number of challenges. For example, utilizing various - and sometimes redundant - Web 2.0 tools can quickly devour limited time. Do you tweet? Do you write press releases? Do you create an exhibit or concept map? The presentation will provide participants with a context for utilizing Web 2.0 tools by briefly highlighting methods of online scientific communication across several dimensions. It will address issues of: * breadth and depth (e.g. from narrow topics to well-rounded views), * presentation methods (e.g. from text to multimedia, from momentary to enduring), * sources and audiences (e.g. for experts or for the public, content developed by producers to that developed by users), * content display (e.g. from linear to non-linear, from instructive to entertaining), * barriers to entry (e.g. from an incumbent advantage to neophyte accessible, from amateur to professional), * cost and reach (e.g. from cheap to expensive), and * impact (e.g. the amount learned, from anonymity to brand awareness). Against this backdrop, the presentation will provide an overview of two methods of online information dissemination, exhibits and concept maps, using the WebExhibits online museum (www.webexhibits.org) and SpicyNodes information visualization tool (www.spicynodes.org) as examples, with tips on how geoscientists can use either to communicate their science. Richly interactive online exhibits can serve to engage a large audience, appeal to visitors with multiple learning styles, prompt exploration and discovery, and present a topic’s breadth and depth. WebExhibits, which was among the first online museums, delivers interactive information, virtual experiments, and hands-on activities to the public. While large, multidisciplinary exhibits on topics like “Color Vision and Art” or “Calendars Through the Ages” require teams of scholars, user interface experts, professional writers and editors

  9. 76 FR 60962 - Noise Exposure Map Update for Buffalo Niagara International Airport, Buffalo, NY

    Science.gov (United States)

    2011-09-30

    ... ``2008 Noise Exposure Map with Land Use'' and Figure 9 ``2013 Noise Exposure Map & Affected Land Uses... meet applicable regulations and which depict non-compatible land uses as of the date of submission of... land use control and planning responsibilities of local government. These local responsibilities are...

  10. Probability mapping of contaminants

    Energy Technology Data Exchange (ETDEWEB)

    Rautman, C.A.; Kaplan, P.G. [Sandia National Labs., Albuquerque, NM (United States); McGraw, M.A. [Univ. of California, Berkeley, CA (United States); Istok, J.D. [Oregon State Univ., Corvallis, OR (United States); Sigda, J.M. [New Mexico Inst. of Mining and Technology, Socorro, NM (United States)

    1994-04-01

    Exhaustive characterization of a contaminated site is a physical and practical impossibility. Descriptions of the nature, extent, and level of contamination, as well as decisions regarding proposed remediation activities, must be made in a state of uncertainty based upon limited physical sampling. The probability mapping approach illustrated in this paper appears to offer site operators a reasonable, quantitative methodology for many environmental remediation decisions and allows evaluation of the risk associated with those decisions. For example, output from this approach can be used in quantitative, cost-based decision models for evaluating possible site characterization and/or remediation plans, resulting in selection of the risk-adjusted, least-cost alternative. The methodology is completely general, and the techniques are applicable to a wide variety of environmental restoration projects. The probability-mapping approach is illustrated by application to a contaminated site at the former DOE Feed Materials Production Center near Fernald, Ohio. Soil geochemical data, collected as part of the Uranium-in-Soils Integrated Demonstration Project, have been used to construct a number of geostatistical simulations of potential contamination for parcels approximately the size of a selective remediation unit (the 3-m width of a bulldozer blade). Each such simulation accurately reflects the actual measured sample values, and reproduces the univariate statistics and spatial character of the extant data. Post-processing of a large number of these equally likely statistically similar images produces maps directly showing the probability of exceeding specified levels of contamination (potential clean-up or personnel-hazard thresholds).

  11. Probability mapping of contaminants

    International Nuclear Information System (INIS)

    Rautman, C.A.; Kaplan, P.G.; McGraw, M.A.; Istok, J.D.; Sigda, J.M.

    1994-01-01

    Exhaustive characterization of a contaminated site is a physical and practical impossibility. Descriptions of the nature, extent, and level of contamination, as well as decisions regarding proposed remediation activities, must be made in a state of uncertainty based upon limited physical sampling. The probability mapping approach illustrated in this paper appears to offer site operators a reasonable, quantitative methodology for many environmental remediation decisions and allows evaluation of the risk associated with those decisions. For example, output from this approach can be used in quantitative, cost-based decision models for evaluating possible site characterization and/or remediation plans, resulting in selection of the risk-adjusted, least-cost alternative. The methodology is completely general, and the techniques are applicable to a wide variety of environmental restoration projects. The probability-mapping approach is illustrated by application to a contaminated site at the former DOE Feed Materials Production Center near Fernald, Ohio. Soil geochemical data, collected as part of the Uranium-in-Soils Integrated Demonstration Project, have been used to construct a number of geostatistical simulations of potential contamination for parcels approximately the size of a selective remediation unit (the 3-m width of a bulldozer blade). Each such simulation accurately reflects the actual measured sample values, and reproduces the univariate statistics and spatial character of the extant data. Post-processing of a large number of these equally likely statistically similar images produces maps directly showing the probability of exceeding specified levels of contamination (potential clean-up or personnel-hazard thresholds)

  12. Mapping the brain

    International Nuclear Information System (INIS)

    Begley, S.; Wright, L.; Church, V.; Hager, M.

    1992-01-01

    With powerful new technologies such as positron tomography and superconducting quantum interference device that peer through the skull and see the brain at work, neuroscientists seek the wellsprings of thoughts and emotions, the genesis of intelligence and language. A functional map of the brain is thus obtained and its challenge is to move beyond brain structure to create a detailed diagram of which part do what. For that the brain's cartographers rely on a variety of technologies such as positron tomography and superconducting quantum interference devices. Their performances and uses are briefly reviewed. ills

  13. Mapping the gendered city

    DEFF Research Database (Denmark)

    Almahmood, Mohammed Abdulrahman M; Scharnhorst, Eric; Carstensen, Trine Agervig

    2017-01-01

    opportunities for gender interaction. However, streets are socially conceived as men’s walkscapes, which limits women’s presence, especially at certain times of the day. This paper reveals how walking experience, tempo-rhythm, sense of place and range of walkscapes are not only determined by ‘universal’ spatial...... Peninsula, where socio-cultural values and restrictions regulate men and women’s use and access to public spaces. The methodology used is a combination of movement tracking data using GPS technology and map-based workshops where participants can reflect on their walking behaviour and spatial preferences...

  14. Bisimulation and open maps

    DEFF Research Database (Denmark)

    Joyal, André; Nielsen, Mogens; Winskel, Glynn

    1993-01-01

    Petri nets), and labeled event structures are considered. On transition systems, the abstract definition readily specialises to Milner's (1989) strong bisimulation. On event structures, it explains and leads to a revision of the history-preserving bisimulation of Rabinovitch and Traktenbrot (1988......), and Goltz and van Glabeek (1989). A tie-up with open maps in a (pre)topos brings to light a promising new model, presheaves on categories of pomsets, into which the usual category of labeled event structures embeds fully and faithfully. As an indication of its promise, this new presheaf model has refinement...

  15. Journal of Maps

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula

    2009-12-01

    Full Text Available Journal of Maps (JoM (http://www.journalofmaps.com počeo je izlaziti 2005. godine isključivo kao elektronički časopis. Izdavač je School of Earth Sciences and Geography, Kingston University, UK. Budući da ne izlazi u tiskanom izdanju, časopis nema uobičajene sveske. Svescima se, ipak, mogu smatrati članci srodne tematike koji se objavljuju tri puta godišnje – u travnju, kolovozu i prosincu.

  16. Corrosion mapping in pipelines

    International Nuclear Information System (INIS)

    Zscherpel, U.; Alekseychuk, O.; Bellon, C.; Ewert, U.; Rost, P.; Schmid, M.

    2002-01-01

    In a joint research project, BASF AG and BAM analyzed the state of the art of tangential radiography of pipes and developed more efficient methods of evaluation. Various PC applications were developed and tested: 1. A program for routine evaluation of digital radiographic images. 2. 3D simulation of the tangential projection of pipes for common radiation sources and various different detectors. 3. Preliminary work on combined evaluation of digital projections and wall thickness changes in radiation direction resulted in a new manner of image display, i.e. the so-called 'corrosion mapping', in which the wall thickness is displayed as a 2D picture above the pipe surface [de

  17. Mapping Wind Energy Controversies

    DEFF Research Database (Denmark)

    Munk, Anders Kristian

    As part the Wind2050 project funded by the Danish Council for Strategic Research we have mapped controversies on wind energy as they unfold online. Specifically we have collected two purpose built datasets, a web corpus containing information from 758 wind energy websites in 6 different countries......, and a smaller social media corpus containing information from 14 Danish wind energy pages on Facebook. These datasets have been analyzed to answer questions like: How do wind proponents and opponents organize online? Who are the central actors? And what are their matters of concern? The purpose of this report...

  18. Mapping of renewable energies

    International Nuclear Information System (INIS)

    Boulanger, V.

    2013-01-01

    Germany is the champion of green energy in Europe: the contribution of renewable energies to electricity generation reached about 20% in 2011. This article describes the situation of renewable energies in Germany in 2011 with the help of 2 maps, the first one gives the installed electrical generation capacity for each region and for each renewable energy source (wind power, hydro-electricity, biomass, photovoltaic energy and biogas) and the second one details the total number of jobs (direct and indirect) for each renewable energy source and for each region. In 2011 about 372000 people worked in the renewable energy sector in Germany. (A.C.)

  19. Between Maps and Territories

    DEFF Research Database (Denmark)

    Holmboe, Rasmus; Stricker, Jan Høgh

    2016-01-01

    This audio paper departs from an artwork made by Andreas Führer called The Map is Not The Territory D’Or; a score for a soundwalk in the town of Roskilde, Denmark. The basic sound materials used in the audio paper are 1) an interview in Danish with the artist, 2) a voice over of a theoretical text...... in English, and 3) recordings from performances of the piece, including walking, breathing exercises, and the sounds of ventilation systems and other environmental sound. By mingling these different materials, and by using ‘map’ and ‘territory’ as metaphors, the paper complicates issues of representation...

  20. YouGenMap: a web platform for dynamic multi-comparative mapping and visualization of genetic maps

    Science.gov (United States)

    Keith Batesole; Kokulapalan Wimalanathan; Lin Liu; Fan Zhang; Craig S. Echt; Chun Liang

    2014-01-01

    Comparative genetic maps are used in examination of genome organization, detection of conserved gene order, and exploration of marker order variations. YouGenMap is an open-source web tool that offers dynamic comparative mapping capability of users' own genetic mapping between 2 or more map sets. Users' genetic map data and optional gene annotations are...

  1. Online maps with APIs and webservices

    CERN Document Server

    Peterson, Michael P

    2014-01-01

    With the Internet now the primary method of accessing maps, this volume examines developments in the world of online map delivery, focusing in particular on application programmer interfaces such as the Google Maps API, and their utility in thematic mapping.

  2. From Google Maps to Google Models (Invited)

    Science.gov (United States)

    Moore, R. V.

    2010-12-01

    Why hasn’t integrated modelling taken off? To its advocates, it is self-evidently the best and arguably the only tool available for understanding and predicting the likely response of the environment to events and policies. Legislation requires managers to ensure that their plans are sustainable. How, other than by modelling the interacting processes involved, can the option with the greatest benefits be identified? Integrated modelling (IM) is seen to have huge potential. In science, IM is used to extend and encapsulate our understanding of the whole earth system. Such models are beginning to be incorporated in operational decision support systems and used to seek sustainable solutions to society’s problems, but only on a limited scale. Commercial take up is negligible yet the opportunities would appear limitless. The need is there; the potential is there, so what is inhibiting IM’s take up? What must be done to reap the rewards of the R & D to date? To answer the question, it useful to look back at the developments which have seen paper maps evolve into Google Maps and the systems that now surround it; facilities available not just to experts and governments but to anyone with a an iphone and an internet connection. The initial objective was to automate the process of drawing lines on paper, though it was quickly realised that digitising maps was the key to unlocking the information they held. However, it took thousands of PhD and MSc projects before a computer could generate a map comparable to that produced by a cartographer and many more before it was possible to extract reliable useful information from maps. It also required advances in IT and a change of mindset from one focused on paper map production to one focused on information delivery. To move from digital maps to Google Maps required the availability of data on a world scale, the resources to bring them together, the development of remote sensing, satellite navigation and communications

  3. BAC-HAPPY mapping (BAP mapping: a new and efficient protocol for physical mapping.

    Directory of Open Access Journals (Sweden)

    Giang T H Vu

    2010-02-01

    Full Text Available Physical and linkage mapping underpin efforts to sequence and characterize the genomes of eukaryotic organisms by providing a skeleton framework for whole genome assembly. Hitherto, linkage and physical "contig" maps were generated independently prior to merging. Here, we develop a new and easy method, BAC HAPPY MAPPING (BAP mapping, that utilizes BAC library pools as a HAPPY mapping panel together with an Mbp-sized DNA panel to integrate the linkage and physical mapping efforts into one pipeline. Using Arabidopsis thaliana as an exemplar, a set of 40 Sequence Tagged Site (STS markers spanning approximately 10% of chromosome 4 were simultaneously assembled onto a BAP map compiled using both a series of BAC pools each comprising 0.7x genome coverage and dilute (0.7x genome samples of sheared genomic DNA. The resultant BAP map overcomes the need for polymorphic loci to separate genetic loci by recombination and allows physical mapping in segments of suppressed recombination that are difficult to analyze using traditional mapping techniques. Even virtual "BAC-HAPPY-mapping" to convert BAC landing data into BAC linkage contigs is possible.

  4. Mapping the Field

    DEFF Research Database (Denmark)

    Goerres, Achim; Vanhuysse, Pieter

    2012-01-01

    Whereas the call for a political science based study of older people and ageing is not new (Cutler 1977; Heclo 1988), relatively little unified progress has been made so far. This chapter maps the field of generational politics and introduces our edited volume "Ageing Populations in Post-Industri......Whereas the call for a political science based study of older people and ageing is not new (Cutler 1977; Heclo 1988), relatively little unified progress has been made so far. This chapter maps the field of generational politics and introduces our edited volume "Ageing Populations in Post...... boxes by asking a number of central questions. How does population aging change political support for redistribution towards different age groups in society, including not just elderly people but also families with children? How, and when, do established parties in aging democracies implement policies......? The answers provided in this volume promise to be of major interest to scholars in fields such as political economy, political sociology, social policy, comparative politics, demography, and gerontology....

  5. Quantitive DNA Fiber Mapping

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Chun-Mei; Wang, Mei; Greulich-Bode, Karin M.; Weier, Jingly F.; Weier, Heinz-Ulli G.

    2008-01-28

    Several hybridization-based methods used to delineate single copy or repeated DNA sequences in larger genomic intervals take advantage of the increased resolution and sensitivity of free chromatin, i.e., chromatin released from interphase cell nuclei. Quantitative DNA fiber mapping (QDFM) differs from the majority of these methods in that it applies FISH to purified, clonal DNA molecules which have been bound with at least one end to a solid substrate. The DNA molecules are then stretched by the action of a receding meniscus at the water-air interface resulting in DNA molecules stretched homogeneously to about 2.3 kb/{micro}m. When non-isotopically, multicolor-labeled probes are hybridized to these stretched DNA fibers, their respective binding sites are visualized in the fluorescence microscope, their relative distance can be measured and converted into kilobase pairs (kb). The QDFM technique has found useful applications ranging from the detection and delineation of deletions or overlap between linked clones to the construction of high-resolution physical maps to studies of stalled DNA replication and transcription.

  6. ANNUAL INTERVIEWS (MAPS)

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The calendar for the 2002/2003 annual interview programme is confirmed as normally from 15 November 2002 to 15 February 2002 as foreseen in Administrative Circular N° 26 (rev. 2). However, where it is preferred to be as close as possible to 12 months since the last interview, supervisors and staff concerned may agree to the interview taking place up to 15 March 2003. This may also be necessary due to the roles of different supervisors resulting from the particular situations of divisional re-restructurings and detachments this year. The report form template is as last year available on the HR Division Website. A banner on the internal homepage leads directly to the page with the form. In collaboration with AS Division, the MAPS form including the personal data for the first page can be generated via the Human Resources Toolkit (HRT) application. For this exercise each staff member can now generate his/her own MAPS form. Information about how to do this is available here. Human Resources Division Tel. ...

  7. REST-MapReduce: An Integrated Interface but Differentiated Service

    Directory of Open Access Journals (Sweden)

    Jong-Hyuk Park

    2014-01-01

    Full Text Available With the fast deployment of cloud computing, MapReduce architectures are becoming the major technologies for mobile cloud computing. The concept of MapReduce was first introduced as a novel programming model and implementation for a large set of computing devices. In this research, we propose a novel concept of REST-MapReduce, enabling users to use only the REST interface without using the MapReduce architecture. This approach provides a higher level of abstraction by integration of the two types of access interface, REST API and MapReduce. The motivation of this research stems from the slower response time for accessing simple RDBMS on Hadoop than direct access to RDMBS. This is because there is overhead to job scheduling, initiating, starting, tracking, and management during MapReduce-based parallel execution. Therefore, we provide a good performance for REST Open API service and for MapReduce, respectively. This is very useful for constructing REST Open API services on Hadoop hosting services, for example, Amazon AWS (Macdonald, 2005 or IBM Smart Cloud. For evaluating performance of our REST-MapReduce framework, we conducted experiments with Jersey REST web server and Hadoop. Experimental result shows that our approach outperforms conventional approaches.

  8. LAN MAP: An Innovative Airborne Light at Night Mapping Project

    Science.gov (United States)

    Craine, Eric R.; Craine, B. L.; Craine, E. M.; Craine, P. R.

    2013-01-01

    Widespread installation of inefficient and misdirected artificial light at night (LAN) has led to increasing concerns about light pollution and its impact, not only on astronomical facilities but larger communities as well. Light pollution impacts scientific research, environmental ecosystems, human health, and quality of life. In recent years, the public policy response to light pollution has included formulation of government codes to regulate lighting design and installation. Various environmental groups now include light pollution among their rallying themes to protest both specific and general developments. The latter efforts are often conducted in the absence of any quantitative data and are frequently charged by emotion rather than reason. To bring some scientific objectivity, and quantitative data, to these discussions, we have developed a suite of tools for simultaneous photometric measurements and temporal monitoring of both local communities and the sky overhead. We have also developed novel protocols for the use of these tools, including a triad of airborne, ground mobile, and ground static photometric surveys. We present a summary of these tools and protocols, with special emphasis on the airborne systems, and discuss baseline and follow-up measurements of LAN environments in the vicinity of numerous observatories in Arizona, the home of the initial LAN MAP surveys.

  9. A phenomenographic case study: Concept maps from the perspectives of middle school students

    Science.gov (United States)

    Saglam, Yilmaz

    The objective of this study was to investigate the experiences of middle school students when concept maps were used as a learning tool. Twenty-nine students' written responses, concept maps and videotapes were analyzed. Out of 29 students, thirteen students were interviewed using a semi-structured and open-ended interview protocol. The students' initial written responses provided us with the students' initial reactions to concept maps. The videotapes captured the students' behavior, and interpersonal interactions. The interviews probed students': (1) knowledge about drawing concept maps, (2) perception of the meaning and usefulness of concept maps, and (3) attitudes towards concept maps. The results indicated that the students viewed concept maps as useful tools in learning science. They believed that concept maps organized and summarized the information, which thereby helped them understand the topic easily. They also believed that concept maps had some cognitive benefits. However, the students viewed concept maps as hard to construct because it was difficult for the students to think of related concepts. The students' initial written responses, interviews and videotapes indicated that the students seemed to see both positive and negative aspects of concept maps. Some students' had more positive and some had more negative attitudes.

  10. Planetary Geologic Mapping Handbook - 2009

    Science.gov (United States)

    Tanaka, K. L.; Skinner, J. A.; Hare, T. M.

    2009-01-01

    Geologic maps present, in an historical context, fundamental syntheses of interpretations of the materials, landforms, structures, and processes that characterize planetary surfaces and shallow subsurfaces (e.g., Varnes, 1974). Such maps also provide a contextual framework for summarizing and evaluating thematic research for a given region or body. In planetary exploration, for example, geologic maps are used for specialized investigations such as targeting regions of interest for data collection and for characterizing sites for landed missions. Whereas most modern terrestrial geologic maps are constructed from regional views provided by remote sensing data and supplemented in detail by field-based observations and measurements, planetary maps have been largely based on analyses of orbital photography. For planetary bodies in particular, geologic maps commonly represent a snapshot of a surface, because they are based on available information at a time when new data are still being acquired. Thus the field of planetary geologic mapping has been evolving rapidly to embrace the use of new data and modern technology and to accommodate the growing needs of planetary exploration. Planetary geologic maps have been published by the U.S. Geological Survey (USGS) since 1962 (Hackman, 1962). Over this time, numerous maps of several planetary bodies have been prepared at a variety of scales and projections using the best available image and topographic bases. Early geologic map bases commonly consisted of hand-mosaicked photographs or airbrushed shaded-relief views and geologic linework was manually drafted using mylar bases and ink drafting pens. Map publishing required a tedious process of scribing, color peel-coat preparation, typesetting, and photo-laboratory work. Beginning in the 1990s, inexpensive computing, display capability and user-friendly illustration software allowed maps to be drawn using digital tools rather than pen and ink, and mylar bases became obsolete

  11. Visualizing Dynamic Data with Maps.

    Science.gov (United States)

    Mashima, Daisuke; Kobourov, Stephen G; Hu, Yifan

    2012-09-01

    Maps offer a familiar way to present geographic data (continents, countries), and additional information (topography, geology), can be displayed with the help of contours and heat-map overlays. In this paper, we consider visualizing large-scale dynamic relational data by taking advantage of the geographic map metaphor. We describe a map-based visualization system which uses animation to convey dynamics in large data sets, and which aims to preserve the viewer's mental map while also offering readable views at all times. Our system is fully functional and has been used to visualize user traffic on the Internet radio station last.fm, as well as TV-viewing patterns from an IPTV service. All map images in this paper are available in high-resolution at [1] as are several movies illustrating the dynamic visualization.

  12. Knowledge Map of Facilities Management

    DEFF Research Database (Denmark)

    Nenonen, Suvi; Jensen, Per Anker; Lindahl, Göran

    2014-01-01

    both the research community and FM-practitioners can develop new models for identifying knowledge needs and gaps and to improve knowledge sharing and knowledge flow and thus the fulfilment of their mission and goals. Knowledge maps can also help in organizing research activities and analysing......Purpose This paper aims to draft a knowledge map of the fragmented and multidisciplinary research of and relevant to FM. Facilities management knowledge map is a tool for presenting what relevant data and knowledge, a.k.a. knowledge, resides in different disciplines. Knowledge mapping is a step...... in creating an inventory of knowledge (i.e. the knowledge base) and developing/improving the processes of knowledge sharing in research, education and practice. Theory Knowledge mapping is discussed in terms of knowledge management. The research is connected to knowledge mapping in the facilities management...

  13. Quantum Programs as Kleisli Maps

    Directory of Open Access Journals (Sweden)

    Abraham Westerbaan

    2017-01-01

    Full Text Available Furber and Jacobs have shown in their study of quantum computation that the category of commutative C*-algebras and PU-maps (positive linear maps which preserve the unit is isomorphic to the Kleisli category of a comonad on the category of commutative C*-algebras with MIU-maps (linear maps which preserve multiplication, involution and unit. [Furber and Jacobs, 2013] In this paper, we prove a non-commutative variant of this result: the category of C*-algebras and PU-maps is isomorphic to the Kleisli category of a comonad on the subcategory of MIU-maps. A variation on this result has been used to construct a model of Selinger and Valiron's quantum lambda calculus using von Neumann algebras. [Cho and Westerbaan, 2016

  14. Synchronizability of coupled PWL maps

    International Nuclear Information System (INIS)

    Polynikis, A.; Di Bernardo, M.; Hogan, S.J.

    2009-01-01

    In this paper we discuss the phenomenon of synchronization of chaotic systems in the case of coupled piecewise linear (PWL) continuous and discontinuous one-dimensional maps. We present numerical results for two examples of coupled systems consisting of two PWL maps. We illustrate how the coupled system can achieve synchronization and discuss the nature of the bifurcation that occurs at a critical value of the coupling strength. We then determine this critical coupling using linear stability analysis. We discuss the effects of variation of the parameters of the PWL maps on the critical coupling and present different bifurcation scenarios obtained for different sets of values of these parameters. Finally, we discuss an extension of our work to the synchronizability of networks consisting of two or more PWL maps. We show how the synchronizability of a network of PWL maps can be improved by tuning the map parameters.

  15. Imagining Geographies, Mapping Identities

    Directory of Open Access Journals (Sweden)

    Matthew Graves

    2015-03-01

    Full Text Available The ambition of this issue of Portal is to reach across the methodological boundaries of history, politics, literature and geography to apply their complementary perspectives to the study of identity and its relation to space and place, an aim that involves attempting to identify the many different ways the notoriously slippery concepts of identity and geography may intersect. For this issue we have selected articles that cast a fresh perspective on two areas where identity and geography intersect: the construction of identity through the imaginative recreation of place in literature: Mapping Literary Spaces; and the study of the shifting relationships of centre and periphery, exclusion and inclusion in urban settings and geopolitical confrontations: Social and Political Peripheries. Gerard Toal has written that geography is not a noun but a verb: it does not describe what space is but studies what we do with space, imaginatively and politically. The articles in this issue illustrate the exercise of the literary and political imagination and the role of materiality and memory in the creation of geographic representation. They show too a new awareness of the centrality of space in the constitution of identities, and the need for a new geocritical reading of its discourse, as the interrelations of place and community are played out on the many scales of social and political life, from the local to the global.   The special issue is organised thus: Introduction Matthew Graves (Aix-Marseille University & Liz Rechniewski (Sydney University: “Imagining Geographies, Mapping Identities.” I. Mapping Literary Spaces - Isabelle Avila (University of Paris XIII, "Les Cartes de l'Afrique au XIXe siècle et Joseph Conrad : Perceptions d'une Révolution Cartographique." - Daniela Rogobete (University of Craiova, "Global vs Glocal: Dimensions of the post-1981 Indian English Novel." II. Social and Political Peripheries - Elizabeth Rechniewski (Sydney

  16. Panoramic irradiator dose mapping with pin photodiodes

    International Nuclear Information System (INIS)

    Ferreira, Danilo Cardenuto; Napolitano, Celia Marina; Bueno, Carmen Cecilia

    2011-01-01

    In this work we study the possibility of using commercial silicon PIN photodiodes (Siemens, SFH 00206) for dose mapping in the Panoramic Irradiator facility at IPEN-CNEN/SP. The chosen photodiode, that is encased in 1.2 mm thickness polymer layer, displays promising dosimetric characteristics such as small size (sensitive area of 7.00 mm 2 ), high sensitivity and low dark current (≅ 300 pA, at 0 V) together with low-cost and wide availability. The Panoramic facility is an irradiator Type II with absorbed dose certificated by International Dose Assurance Service (IDAS) offered by the International Agency Energy Atomic (IAEA). The charge registered by the diode as a function of the absorbed dose was in excellent agreement with that one calibrated by IDAS. Besides this, the easy handling and fast response of the SFH00206 diode compared to Fricke chemical dosimeters encouraged us to perform dose mapping around the source. (author)

  17. Outcome mapping for health system integration

    Directory of Open Access Journals (Sweden)

    Tsasis P

    2013-03-01

    Full Text Available Peter Tsasis,1 Jenna M Evans,2 David Forrest,3 Richard Keith Jones4 1School of Health Policy and Management, Faculty of Health, York University, Toronto, Canada; 2Institute of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Canada; 3Global Vision Consulting Ltd, Victoria, Canada; 4R Keith Jones and Associates, Victoria, Canada Abstract: Health systems around the world are implementing integrated care strategies to improve quality, reduce or maintain costs, and improve the patient experience. Yet few practical tools exist to aid leaders and managers in building the prerequisites to integrated care, namely a shared vision, clear roles and responsibilities, and a common understanding of how the vision will be realized. Outcome mapping may facilitate stakeholder alignment on the vision, roles, and processes of integrated care delivery via participative and focused dialogue among diverse stakeholders on desired outcomes and enabling actions. In this paper, we describe an outcome-mapping exercise we conducted at a Local Health Integration Network in Ontario, Canada, using consensus development conferences. Our preliminary findings suggest that outcome mapping may help stakeholders make sense of a complex system and foster collaborative capital, a resource that can support information sharing, trust, and coordinated change toward integration across organizational and professional boundaries. Drawing from the theoretical perspectives of complex adaptive systems and collaborative capital, we also outline recommendations for future outcome-mapping exercises. In particular, we emphasize the potential for outcome mapping to be used as a tool not only for identifying and linking strategic outcomes and actions, but also for studying the boundaries, gaps, and ties that characterize social networks across the continuum of care. Keywords: integrated care, integrated delivery systems, complex adaptive systems, social capital

  18. Inflammatory protein response in CDKL5-Rett syndrome: evidence of a subclinical smouldering inflammation.

    Science.gov (United States)

    Cortelazzo, Alessio; de Felice, Claudio; Leoncini, Silvia; Signorini, Cinzia; Guerranti, Roberto; Leoncini, Roberto; Armini, Alessandro; Bini, Luca; Ciccoli, Lucia; Hayek, Joussef

    2017-03-01

    Mutations in the cyclin-dependent kinase-like 5 gene cause a clinical variant of Rett syndrome (CDKL5-RTT). A role for the acute-phase response (APR) is emerging in typical RTT caused by methyl-CpG-binding protein 2 gene mutations (MECP2-RTT). No information is, to date, available on the inflammatory protein response in CDKL5-RTT. We evaluated, for the first time, the APR protein response in CDKL5-RTT. Protein patterns in albumin- and IgG-depleted plasma proteome from CDKL5-RTT patients were evaluated by two-dimensional gel electrophoresis/mass spectrometry. The resulting data were related to circulating cytokines and compared to healthy controls or MECP2-RTT patients. The effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) were evaluated. CDKL5-RTT mutations resulted in a subclinical attenuated inflammation, specifically characterized by an overexpression of the complement component C3 and CD5 antigen-like, both strictly related to the inflammatory response. Cytokine dysregulation featuring a bulk increase of anti-inflammatory cytokines, predominantly IL-10, could explain the unchanged erythrocyte sedimentation rate and atypical features of inflammation in CDKL5-RTT. Omega-3 PUFAs were able to counterbalance the pro-inflammatory status. For the first time, we revealed a subclinical smouldering inflammation pattern in CDKL5-RTT consisting in the coexistence of an atypical APR coupled with a dysregulated cytokine response.

  19. General Galilei Covariant Gaussian Maps

    Science.gov (United States)

    Gasbarri, Giulio; Toroš, Marko; Bassi, Angelo

    2017-09-01

    We characterize general non-Markovian Gaussian maps which are covariant under Galilean transformations. In particular, we consider translational and Galilean covariant maps and show that they reduce to the known Holevo result in the Markovian limit. We apply the results to discuss measures of macroscopicity based on classicalization maps, specifically addressing dissipation, Galilean covariance and non-Markovianity. We further suggest a possible generalization of the macroscopicity measure defined by Nimmrichter and Hornberger [Phys. Rev. Lett. 110, 16 (2013)].

  20. Cosmic string induced CMB maps

    International Nuclear Information System (INIS)

    Landriau, M.; Shellard, E. P. S.

    2011-01-01

    We compute maps of CMB temperature fluctuations seeded by cosmic strings using high resolution simulations of cosmic strings in a Friedmann-Robertson-Walker universe. We create full-sky, 18 deg. and 3 deg. CMB maps, including the relevant string contribution at each resolution from before recombination to today. We extract the angular power spectrum from these maps, demonstrating the importance of recombination effects. We briefly discuss the probability density function of the pixel temperatures, their skewness, and kurtosis.

  1. Transfer maps and projection formulas

    OpenAIRE

    Tabuada, Goncalo

    2010-01-01

    Transfer maps and projection formulas are undoubtedly one of the key tools in the development and computation of (co)homology theories. In this note we develop an unified treatment of transfer maps and projection formulas in the non-commutative setting of dg categories. As an application, we obtain transfer maps and projection formulas in algebraic K-theory, cyclic homology, topological cyclic homology, and other scheme invariants.

  2. Information technology road map 2015

    International Nuclear Information System (INIS)

    2009-09-01

    This book introduces information technology road map 2015 with presentation, process, plan and conclusion of it. It also has introduction of IT road map by field : information technology road map 2015 on the next-generation of semiconductor, display, light emitting diode and light industry, home network and home electronic appliances, digital TV and broadcasting, radio technology, satellite communications, mobile communication for the next-generation, BcN field, software, computer for the next-generation and security of knowledge information.

  3. Symplectic maps for accelerator lattices

    International Nuclear Information System (INIS)

    Warnock, R.L.; Ruth, R.; Gabella, W.

    1988-05-01

    We describe a method for numerical construction of a symplectic map for particle propagation in a general accelerator lattice. The generating function of the map is obtained by integrating the Hamilton-Jacobi equation as an initial-value problem on a finite time interval. Given the generating function, the map is put in explicit form by means of a Fourier inversion technique. We give an example which suggests that the method has promise. 9 refs., 9 figs

  4. Introduction: Hazard mapping

    Science.gov (United States)

    Baum, Rex L.; Miyagi, Toyohiko; Lee, Saro; Trofymchuk, Oleksandr M

    2014-01-01

    Twenty papers were accepted into the session on landslide hazard mapping for oral presentation. The papers presented susceptibility and hazard analysis based on approaches ranging from field-based assessments to statistically based models to assessments that combined hydromechanical and probabilistic components. Many of the studies have taken advantage of increasing availability of remotely sensed data and nearly all relied on Geographic Information Systems to organize and analyze spatial data. The studies used a range of methods for assessing performance and validating hazard and susceptibility models. A few of the studies presented in this session also included some element of landslide risk assessment. This collection of papers clearly demonstrates that a wide range of approaches can lead to useful assessments of landslide susceptibility and hazard.

  5. Turkey Reading Culture Map.

    Directory of Open Access Journals (Sweden)

    Rahmi Akkılık

    2013-11-01

    Full Text Available Derived from the project with the same name, the work was published into a book by the Ministry of Culture and Tourism, Directorate General of Libraries and Publications, the project coordinator. Goal of the project is defined as follows: "specifying the solutions to problems faced directly or indirectly in accessing information, making suggestions to related corporations and persons, determining the perception of libraries in the society, raising the quality of services provided at public libraries and children's libraries affiliated with the Ministry, diversifying these libraries and designating the road map for the future." Carried out with the "method of face-to-face surveys" with 6.212 people in 26 cities, the research revealed the society's habits of reading and library usage.

  6. Mapping cultural ecosystem services:

    DEFF Research Database (Denmark)

    Paracchini, Maria Luisa; Zulian, Grazia; Kopperoinen, Leena

    2014-01-01

    Research on ecosystem services mapping and valuing has increased significantly in recent years. However, compared to provisioning and regulating services, cultural ecosystem services have not yet been fully integrated into operational frameworks. One reason for this is that transdisciplinarity...... surveys are a main source of information. Among cultural ecosystem services, assessment of outdoor recreation can be based on a large pool of literature developed mostly in social and medical science, and landscape and ecology studies. This paper presents a methodology to include recreation...... in the conceptual framework for EU wide ecosystem assessments (Maes et al., 2013), which couples existing approaches for recreation management at country level with behavioural data derived from surveys, and population distribution data. The proposed framework is based on three components: the ecosystem function...

  7. Mapping the universe.

    Science.gov (United States)

    Geller, M J; Huchra, J P

    1989-11-17

    Maps of the galaxy distribution in the nearby universe reveal large coherent structures. The extent of the largest features is limited only by the size of the survey. Voids with a density typically 20 percent of the mean and with diameters of 5000 km s(-1) are present in every survey large enough to contain them. Many galaxies lie in thin sheet-like structures. The largest sheet detected so far is the "Great Wall" with a minimum extent of 60 h(-1) Mpc x 170 h(-1) Mpc, where h is the Hubble constant in units of 100 km s(-1) Mpc(-1). The frequent occurrence of these structures is one of several serious challenges to our current understanding of the origin and evolution of the large-scale distribution of matter in the universe.

  8. Mapping of nitrogen risks

    DEFF Research Database (Denmark)

    Blicher-Mathiesen, Gitte; Andersen, Hans Estrup; Carstensen, Jacob

    2014-01-01

    risk mapping part of the tool, we combined a modelled root zone N leaching with a catchment-specific N reduction factor which in combination determines the N load to the marine recipient. N leaching was calculated using detailed information of agricultural management from national databases as well...... will be more effective if they are implemented in N loss hot spots or risk areas. Additionally, the highly variable N reduction in groundwater and surface waters needs to be taken into account as this strongly influences the resulting effect of mitigation measures. The objectives of this study were to develop...... and apply an N risk tool to the entire agricultural land area in Denmark. The purpose of the tool is to identify high risk areas, i.e. areas which contribute disproportionately much to diffuse N losses to the marine recipient, and to suggest cost-effective measures to reduce losses from risk areas. In the N...

  9. Mapping eParticipation

    DEFF Research Database (Denmark)

    Rose, Jeremy; Sanford, Clive Carlton

    2007-01-01

    The emerging research area of eParticipation can be characterized as the study of technology-facilitated citizen participation in (democratic) deliberation and decision-making. Using conventional literature study techniques, we identify 105 articles that are considered to be highly relevant to e......Participation. We develop a definitional schema that suggests different ways of understanding an emerging socio-technical research area and use this schema to map the research contributions identified. This allows us make an initial sketch of the scientific character of the area and its central concerns, theories......, and methods. We extend the analysis to define four central research challenges for the field: understanding technology and participation; the strategic challenge; the design challenge; and the evaluation challenge. This article thus contributes to a developing account of eParticipation, which will help future...

  10. Resolved Hapke parameter maps of the Moon

    Science.gov (United States)

    Sato, H.; Robinson, M. S.; Hapke, B.; Denevi, B. W.; Boyd, A. K.

    2014-08-01

    We derived spatially resolved near-global Hapke photometric parameter maps of the Moon from 21 months of Lunar Reconnaissance Orbiter Camera (LROC) Wide Angle Camera (WAC) multispectral observations using a novel "tile-by-tile method" (1° latitude by 1° longitude bins). The derived six parameters (w,b,c,BS0,hS, andθ¯p) for each tile were used to normalize the observed reflectance (standard angles i = g = 60°, e = 0° instead of the traditional angles i = g = 30°, e = 0°) within each tile, resulting in accurate normalization optimized for the local photometric response. Each pixel in the seven-color near-global mosaic (70°S to 70°N and 0°E to 360°E) was computed by the median of normalized reflectance from large numbers of repeated observations (UV: ˜50 and visible: ˜126 on average). The derived mosaic exhibits no significant artifacts with latitude or along the tile boundaries, demonstrating the quality of the normalization procedure. The derived Hapke parameter maps reveal regional photometric response variations across the lunar surface. The b, c (Henyey-Greenstein double-lobed phase function parameters) maps demonstrate decreased backscattering in the maria relative to the highlands (except 321 nm band), probably due to the higher content of both SMFe (submicron iron) and ilmenite in the interiors of back scattering agglutinates in the maria. The hS (angular width of shadow hiding opposition effect) map exhibits relatively lower values in the maria than the highlands and slightly higher values for immature highland crater ejecta, possibly related to the variation in a grain size distribution of regolith.

  11. Generating Multi-Destination Maps.

    Science.gov (United States)

    Zhang, Junsong; Fan, Jiepeng; Luo, Zhenshan

    2017-08-01

    Multi-destination maps are a kind of navigation maps aimed to guide visitors to multiple destinations within a region, which can be of great help to urban visitors. However, they have not been developed in the current online map service. To address this issue, we introduce a novel layout model designed especially for generating multi-destination maps, which considers the global and local layout of a multi-destination map. We model the layout problem as a graph drawing that satisfies a set of hard and soft constraints. In the global layout phase, we balance the scale factor between ROIs. In the local layout phase, we make all edges have good visibility and optimize the map layout to preserve the relative length and angle of roads. We also propose a perturbation-based optimization method to find an optimal layout in the complex solution space. The multi-destination maps generated by our system are potential feasible on the modern mobile devices and our result can show an overview and a detail view of the whole map at the same time. In addition, we perform a user study to evaluate the effectiveness of our method, and the results prove that the multi-destination maps achieve our goals well.

  12. Understanding map projections: Chapter 15

    Science.gov (United States)

    Usery, E. Lynn; Kent, Alexander J.; Vujakovic, Peter

    2018-01-01

    It has probably never been more important in the history of cartography than now that people understand how maps work. With increasing globalization, for example, world maps provide a key format for the transmission of information, but are often poorly used. Examples of poor understanding and use of projections and the resultant maps are many; for instance, the use of rectangular world maps in the United Kingdom press to show Chinese and Korean missile ranges as circles, something which can only be achieved on equidistant projections and then only from one launch point (Vujakovic, 2014).

  13. Matching by Monotonic Tone Mapping.

    Science.gov (United States)

    Kovacs, Gyorgy

    2018-06-01

    In this paper, a novel dissimilarity measure called Matching by Monotonic Tone Mapping (MMTM) is proposed. The MMTM technique allows matching under non-linear monotonic tone mappings and can be computed efficiently when the tone mappings are approximated by piecewise constant or piecewise linear functions. The proposed method is evaluated in various template matching scenarios involving simulated and real images, and compared to other measures developed to be invariant to monotonic intensity transformations. The results show that the MMTM technique is a highly competitive alternative of conventional measures in problems where possible tone mappings are close to monotonic.

  14. Feynman maps without improper integrals

    International Nuclear Information System (INIS)

    Exner, P.; Kolerov, G.I.

    1980-01-01

    The Feynman maps introduced first by Truman are examined. The domain considered here consists of the Fresnel-inteo-rable functions in the sense of Albeverio and Hoegh-Krohn. The original definition of the F-maps is slightly modified: it is started from the underlying measures on the Hilbert space of paths in order to avoid use of improper integrals. Some new properties of the F-maps are derived. In particular, the dominated convergence theorem is shown to be not valid for the F 1 -map (or Feynman integral); this fact is of a certain importance for classical limit of quantum mechanics

  15. Seismic hazard map of the western hemisphere

    Science.gov (United States)

    Shedlock, K.M.; Tanner, J.G.

    1999-01-01

    Vulnerability to natural disasters increases with urbanization and development of associated support systems (reservoirs, power plants, etc.). Catastrophic earthquakes account for 60% of worldwide casualties associated with natural disasters. Economic damage from earthquakes is increasing, even in technologically advanced countries with some level of seismic zonation, as shown by the 1989 Loma Prieta, CA ($6 billion), 1994 Northridge, CA ($ 25 billion), and 1995 Kobe, Japan (> $ 100 billion) earthquakes. The growth of megacities in seismically active regions around the world often includes the construction of seismically unsafe buildings and infrastructures, due to an insufficient knowledge of existing seismic hazard. Minimization of the loss of life, property damage, and social and economic disruption due to earthquakes depends on reliable estimates of seismic hazard. National, state, and local governments, decision makers, engineers, planners, emergency response organizations, builders, universities, and the general public require seismic hazard estimates for land use planning, improved building design and construction (including adoption of building construction codes), emergency response preparedness plans, economic forecasts, housing and employment decisions, and many more types of risk mitigation. The seismic hazard map of the Americas is the concatenation of various national and regional maps, involving a suite of approaches. The combined maps and documentation provide a useful global seismic hazard framework and serve as a resource for any national or regional agency for further detailed studies applicable to their needs. This seismic hazard map depicts Peak Ground Acceleration (PGA) with a 10% chance of exceedance in 50 years for the western hemisphere. PGA, a short-period ground motion parameter that is proportional to force, is the most commonly mapped ground motion parameter because current building codes that include seismic provisions specify the

  16. Seismic hazard map of the western hemisphere

    Directory of Open Access Journals (Sweden)

    J. G. Tanner

    1999-06-01

    Full Text Available Vulnerability to natural disasters increases with urbanization and development of associated support systems (reservoirs, power plants, etc.. Catastrophic earthquakes account for 60% of worldwide casualties associated with natural disasters. Economic damage from earthquakes is increasing, even in technologically advanced countries with some level of seismic zonation, as shown by the 1989 Loma Prieta, CA ($ 6 billion, 1994 Northridge, CA ($ 25 billion, and 1995 Kobe, Japan (> $ 100 billion earthquakes. The growth of megacities in seismically active regions around the world often includes the construction of seismically unsafe buildings and infrastructures, due to an insufficient knowledge of existing seismic hazard. Minimization of the loss of life, property damage, and social and economic disruption due to earthquakes depends on reliable estimates of seismic hazard. National, state, and local governments, decision makers, engineers, planners, emergency response organizations, builders, universities, and the general public require seismic hazard estimates for land use planning, improved building design and construction (including adoption of building construction codes, emergency response preparedness plans, economic forecasts, housing and employment decisions, and many more types of risk mitigation. The seismic hazard map of the Americas is the concatenation of various national and regional maps, involving a suite of approaches. The combined maps and documentation provide a useful global seismic hazard framework and serve as a resource for any national or regional agency for further detailed studies applicable to their needs. This seismic hazard map depicts Peak Ground Acceleration (PGA with a 10% chance of exceedance in 50 years for the western hemisphere. PGA, a short-period ground motion parameter that is proportional to force, is the most commonly mapped ground motion parameter because current building codes that include seismic provisions

  17. Mapping infectious disease hospital surge threats to lessons learnt in Singapore: a systems analysis and development of a framework to inform how to DECIDE on planning and response strategies.

    Science.gov (United States)

    Singh, Shweta R; Coker, Richard; Vrijhoef, Hubertus J-M; Leo, Yee Sin; Chow, Angela; Lim, Poh Lian; Tan, Qinghui; Chen, Mark I-Cheng; Hildon, Zoe Jane-Lara

    2017-09-04

    Hospital usage and service demand during an Infectious Disease (ID) outbreak can tax the health system in different ways. Herein we conceptualize hospital surge elements, and lessons learnt from such events, to help build appropriately matched responses to future ID surge threats. We used the Interpretive Descriptive qualitative approach. Interviews (n = 35) were conducted with governance and public health specialists; hospital based staff; and General Practitioners. Key policy literature in tandem with the interview data were used to iteratively generate a Hospital ID Surge framework. We anchored our narrative account within this framework, which is used to structure our analysis. A spectrum of surge threats from combinations of capacity (for crowding) and capability (for treatment complexity) demands were identified. Starting with the Pyramid scenario, or an influx of high screening rates flooding Emergency Departments, alongside fewer and manageable admissions; the Reverse-Pyramid occurs when few cases are screened and admitted but those that are, are complex; during a 'Black' scenario, the system is overburdened by both crowding and complexity. The Singapore hospital system is highly adapted to crowding, functioning remarkably well at constant near-full capacity in Peacetime and resilient to Endemic surges. We catalogue 26 strategies from lessons learnt relating to staffing, space, supplies and systems, crystalizing institutional memory. The DECIDE model advocates linking these strategies to types of surge threats and offers a step-by-step guide for coordinating outbreak planning and response. Lack of a shared definition and decision making of surge threats had rendered the procedures somewhat duplicative. This burden was paradoxically exacerbated by a health system that highly prizes planning and forward thinking, but worked largely in silo until an ID crisis hit. Many such lessons can be put into play to further strengthen our current hospital governance

  18. Digital Geological Mapping for Earth Science Students

    Science.gov (United States)

    England, Richard; Smith, Sally; Tate, Nick; Jordan, Colm

    2010-05-01

    This SPLINT (SPatial Literacy IN Teaching) supported project is developing pedagogies for the introduction of teaching of digital geological mapping to Earth Science students. Traditionally students are taught to make geological maps on a paper basemap with a notebook to record their observations. Learning to use a tablet pc with GIS based software for mapping and data recording requires emphasis on training staff and students in specific GIS and IT skills and beneficial adjustments to the way in which geological data is recorded in the field. A set of learning and teaching materials are under development to support this learning process. Following the release of the British Geological Survey's Sigma software we have been developing generic methodologies for the introduction of digital geological mapping to students that already have experience of mapping by traditional means. The teaching materials introduce the software to the students through a series of structured exercises. The students learn the operation of the software in the laboratory by entering existing observations, preferably data that they have collected. Through this the students benefit from being able to reflect on their previous work, consider how it might be improved and plan new work. Following this they begin fieldwork in small groups using both methods simultaneously. They are able to practise what they have learnt in the classroom and review the differences, advantages and disadvantages of the two methods, while adding to the work that has already been completed. Once the field exercises are completed students use the data that they have collected in the production of high quality map products and are introduced to the use of integrated digital databases which they learn to search and extract information from. The relatively recent development of the technologies which underpin digital mapping also means that many academic staff also require training before they are able to deliver the

  19. Defensive repertoire of Drosophila larvae in response to toxic fungi.

    Science.gov (United States)

    Trienens, Monika; Kraaijeveld, Ken; Wertheim, Bregje

    2017-10-01

    Chemical warfare including insecticidal secondary metabolites is a well-known strategy for environmental microbes to monopolize a food source. Insects in turn have evolved behavioural and physiological defences to eradicate or neutralize the harmful microorganisms. We studied the defensive repertoire of insects in this interference competition by combining behavioural and developmental assays with whole-transcriptome time-series analysis. Confrontation with the toxic filamentous fungus Aspergillus nidulans severely reduced the survival of Drosophila melanogaster larvae. Nonetheless, the larvae did not behaviourally avoid the fungus, but aggregated at it. Confrontation with fungi strongly affected larval gene expression, including many genes involved in detoxification (e.g., CYP, GST and UGT genes) and the formation of the insect cuticle (e.g., Tweedle genes). The most strongly upregulated genes were several members of the insect-specific gene family Osiris, and CHK-kinase-like domains were over-represented. Immune responses were not activated, reflecting the competitive rather than pathogenic nature of the antagonistic interaction. While internal microbes are widely acknowledged as important, our study emphasizes the underappreciated role of environmental microbes as fierce competitors. © 2017 John Wiley & Sons Ltd.

  20. Technical note Flood map development by coupling satellite maps ...

    African Journals Online (AJOL)

    Flood maps are important for local authorities in designing mitigation plans to minimise damage and loss due to flooding. In recent years, flood events in the Sarawak River Basin, Malaysia have caused damage to property, loss of life and disruption of productive activities. Currently, the available flood map for Sarawak River ...

  1. Exploring the genetic architecture and improving genomic prediction accuracy for mastitis and milk production traits in dairy cattle by mapping variants to hepatic transcriptomic regions responsive to intra-mammary infection.

    Science.gov (United States)

    Fang, Lingzhao; Sahana, Goutam; Ma, Peipei; Su, Guosheng; Yu, Ying; Zhang, Shengli; Lund, Mogens Sandø; Sørensen, Peter

    2017-05-12

    A better understanding of the genetic architecture of complex traits can contribute to improve genomic prediction. We hypothesized that genomic variants associated with mastitis and milk production traits in dairy cattle are enriched in hepatic transcriptomic regions that are responsive to intra-mammary infection (IMI). Genomic markers [e.g. single nucleotide polymorphisms (SNPs)] from those regions, if included, may improve the predictive ability of a genomic model. We applied a genomic feature best linear unbiased prediction model (GFBLUP) to implement the above strategy by considering the hepatic transcriptomic regions responsive to IMI as genomic features. GFBLUP, an extension of GBLUP, includes a separate genomic effect of SNPs within a genomic feature, and allows differential weighting of the individual marker relationships in the prediction equation. Since GFBLUP is computationally intensive, we investigated whether a SNP set test could be a computationally fast way to preselect predictive genomic features. The SNP set test assesses the association between a genomic feature and a trait based on single-SNP genome-wide association studies. We applied these two approaches to mastitis and milk production traits (milk, fat and protein yield) in Holstein (HOL, n = 5056) and Jersey (JER, n = 1231) cattle. We observed that a majority of genomic features were enriched in genomic variants that were associated with mastitis and milk production traits. Compared to GBLUP, the accuracy of genomic prediction with GFBLUP was marginally improved (3.2 to 3.9%) in within-breed prediction. The highest increase (164.4%) in prediction accuracy was observed in across-breed prediction. The significance of genomic features based on the SNP set test were correlated with changes in prediction accuracy of GFBLUP (P layers of biological knowledge to provide novel insights into the biological basis of complex traits, and to improve the accuracy of genomic prediction. The SNP set

  2. NeatMap--non-clustering heat map alternatives in R.

    Science.gov (United States)

    Rajaram, Satwik; Oono, Yoshi

    2010-01-22

    The clustered heat map is the most popular means of visualizing genomic data. It compactly displays a large amount of data in an intuitive format that facilitates the detection of hidden structures and relations in the data. However, it is hampered by its use of cluster analysis which does not always respect the intrinsic relations in the data, often requiring non-standardized reordering of rows/columns to be performed post-clustering. This sometimes leads to uninformative and/or misleading conclusions. Often it is more informative to use dimension-reduction algorithms (such as Principal Component Analysis and Multi-Dimensional Scaling) which respect the topology inherent in the data. Yet, despite their proven utility in the analysis of biological data, they are not as widely used. This is at least partially due to the lack of user-friendly visualization methods with the visceral impact of the heat map. NeatMap is an R package designed to meet this need. NeatMap offers a variety of novel plots (in 2 and 3 dimensions) to be used in conjunction with these dimension-reduction techniques. Like the heat map, but unlike traditional displays of such results, it allows the entire dataset to be displayed while visualizing relations between elements. It also allows superimposition of cluster analysis results for mutual validation. NeatMap is shown to be more informative than the traditional heat map with the help of two well-known microarray datasets. NeatMap thus preserves many of the strengths of the clustered heat map while addressing some of its deficiencies. It is hoped that NeatMap will spur the adoption of non-clustering dimension-reduction algorithms.

  3. Quantitative mapping of hepatic perfusion index using MR imaging: a potential reproducible tool for assessing tumour response to treatment with the antiangiogenic compound BIBF 1120, a potent triple angiokinase inhibitor

    International Nuclear Information System (INIS)

    Miyazaki, Keiko; Collins, David J.; Walker-Samuel, Simon; Leach, Martin O.; Koh, Dow-Mu; Taylor, Jane N.; Padhani, Anwar R.

    2008-01-01

    Hepatic metastases are arterially supplied, resulting in an elevated hepatic perfusion index (HPI). The purpose of this study was to use dynamic contrast-enhanced (DCE) MR imaging to quantify the HPI of metastases and the liver before and after treatment with a novel antiangiogenic drug. Ten patients with known metastatic liver disease underwent DCE-MR studies. HPIs of metastases and whole liver were derived using regions of interest (ROIs) and calculated on a pixel-by-pixel basis from quantified changes in gadopentetate dimeglumine (Gd-DTPA) concentration. The HPI measurement error prior to treatment was derived by the Bland-Altman analysis. The median HPI before and after treatment with antiangiogenic drug BIBF 1120 were compared using the Wilcoxon signed rank test. Prior to treatment, the median HPI of metastases, 0.75 ± 0.14, was significantly higher than that of the whole liver, 0.66 ± 0.16 (p < 0.01). Bland-Altman reproducibility coefficients of the median HPI from metastases and whole liver were 13.0 and 5.1% respectively. The median HPI of metastases decreased significantly at 28 days after treatment with BIBF 1120 (p < 0.05). This pilot study demonstrates that HPI determined using quantified Gd-DTPA concentration is reproducible and may be useful for monitoring antiangiogenic treatment response of hepatic metastases. (orig.)

  4. Hazard Map for Autonomous Navigation

    DEFF Research Database (Denmark)

    Riis, Troels

    This dissertation describes the work performed in the area of using image analysis in the process of landing a spacecraft autonomously and safely on the surface of the Moon. This is suggested to be done using a Hazard Map. The correspondence problem between several Hazard Maps are investigated...

  5. Methods to Measure Map Readability

    OpenAIRE

    Harrie, Lars

    2009-01-01

    Creation of maps in real-time web services introduces challenges concerning map readability. Therefore we must introduce analytical measures controlling the readability. The aim of this study is to develop and evaluate analytical readability measures with the help of user tests.

  6. Mapping earthworm communities in Europe

    DEFF Research Database (Denmark)

    Rutgers, Michiel; Orgiazzi, Alberto; Gardi, Ciro

    Existing data sets on earthworm communities in Europe were collected, harmonized, modelled and depicted on a soil biodiversity map of Europe. Digital Soil Mapping was applied using multiple regressions relating relatively low density earthworm community data to soil characteristics, land use...

  7. The peatland map of Europe

    NARCIS (Netherlands)

    Tanneberger, Franziska; Tegetmeyer, C.; Busse, S.; Barthelmes, A.; Shumka, S.; Mariné, A.M.; Jenderedjian, K.; Steiner, G.M.; Essl, F.; Etzold, J.; Mendes, C.; Kozulin, A.; Frankard, P.; Milanović,; Ganeva, A.; Apostolova, I.; Alegro, A.; Delipetrou, P.; Navrátilová, J.; Risager, M.; Leivits, A.; Fosaa, A.M.; Tuominen, S.; Muller, F.; Bakuradze, T.; Sommer, M.; Christanis, K.; Szurdoki, E.; Oskarsson, H.; Brink, S.H.; Connolly, J.; Bragazza, L.; Martinelli, G.; Aleksāns, O.; Priede, A.; Sungaila, D.; Melovski, L.; Belous, T.; Saveljić, D.; Vries, De F.; Moen, A.; Dembek, W.; Mateus, J.; Hanganu, J.; Sirin, A.; Markina, A.; Napreenko, M.; Lazarević, P.; Stanová, V.Š.; Skoberne, P.; Pérez, P.H.; Pontevedra-Pombal, X.; Lonnstad, J.; Küchler, M.; Wüst-Galley, C.; Kirca, S.; Mykytiuk, O.; Lindsay, R.; Joosten, H.

    2017-01-01

    Based on the ‘European Mires Book’ of the International Mire Conservation Group (IMCG), this article provides a composite map of national datasets as the first comprehensive peatland map for the whole of Europe. We also present estimates of the extent of peatlands and mires in each European country

  8. Bioinformatics of genomic association mapping

    NARCIS (Netherlands)

    Vaez Barzani, Ahmad

    2015-01-01

    In this thesis we present an overview of bioinformatics-based approaches for genomic association mapping, with emphasis on human quantitative traits and their contribution to complex diseases. We aim to provide a comprehensive walk-through of the classic steps of genomic association mapping

  9. Advances in mobile mapping technology

    CERN Document Server

    Tao; Li, Jonathan

    2007-01-01

    With the increasing availability of low-cost and portable sensors, mobile mapping has become more dynamic, and even pervasive. The book addresses a wide variety of research issues in the mobile mapping community, ranging from system development to sensor integration, imaging algorithms and mobile GIS applications.

  10. Personalized 2D color maps

    KAUST Repository

    Waldin, Nicholas; Bernhard, Matthias; Rautek, Peter; Viola, Ivan

    2016-01-01

    . In this paper we present a novel method to measure a user's ability to distinguish colors of a two-dimensional color map on a given monitor. We show how to adapt the color map to the user and display to optimally compensate for the measured deficiencies

  11. Concept Maps in Introductory Statistics

    Science.gov (United States)

    Witmer, Jeffrey A.

    2016-01-01

    Concept maps are tools for organizing thoughts on the main ideas in a course. I present an example of a concept map that was created through the work of students in an introductory class and discuss major topics in statistics and relationships among them.

  12. Mapping the backbone of science.

    Energy Technology Data Exchange (ETDEWEB)

    Klavans, Richard (Indiana University, Bloomington, IN); BÞorner, Katy (Strategies for Science & Technology, Incorporation, Berwyn, PA); Boyack, Kevin W.

    2004-11-01

    This paper presents a new map representing the structure of all of science, based on journal articles, including both the natural and social sciences. Similar to cartographic maps of our world, the map of science provides a bird's eye view of today's scientific landscape. It can be used to visually identify major areas of science, their size, similarity, and interconnectedness. In order to be useful, the map needs to be accurate on a local and on a global scale. While our recent work has focused on the former aspect, this paper summarizes results on how to achieve structural accuracy. Eight alternative measures of journal similarity were applied to a data set of 7,121 journals covering over 1 million documents in the combined Science Citation and Social Science Citation Indexes. For each journal similarity measure we generated two-dimensional spatial layouts using the force-directed graph layout tool, VxOrd. Next, mutual information values were calculated for each graph at different clustering levels to give a measure of structural accuracy for each map. The best co-citation and inter-citation maps according to local and structural accuracy were selected and are presented and characterized. These two maps are compared to establish robustness. The inter-citation map is then used to examine linkages between disciplines. Biochemistry appears as the most interdisciplinary discipline in science.

  13. Mind Maps as Classroom Exercises

    Science.gov (United States)

    Budd, John W.

    2004-01-01

    A Mind Map is an outline in which the major categories radiate from a central image and lesser categories are portrayed as branches of larger branches. The author describes an in-class exercise in which small groups of students each create a Mind Map for a specific topic. This exercise is another example of an active and collaborative learning…

  14. Tropical varieties, maps and gossip

    NARCIS (Netherlands)

    Frenk, B.J.

    2013-01-01

    Tropical geometry is a relatively new field of mathematics that studies the tropicalization map: a map that assigns a certain type of polyhedral complex, called a tropical variety, to an embedded algebraic variety. In a sense, it translates algebraic geometric statements into combinatorial ones. An

  15. Digital Story Mapping to Advance Educational Atlas Design and Enable Student Engagement

    Directory of Open Access Journals (Sweden)

    Margo E. Berendsen

    2018-03-01

    Full Text Available Storytelling is recognized as a valid and important method of communicating information and knowledge gleaned from volumes of ever-accumulating data. Practices of data-driven storytelling in journalism and geovisual analytics have contributed to the development of geovisual stories; also called story maps. The benefits of student-focused multi-thematic atlases and digital storytelling methods in education can also be realized in story maps. An online, interactive version of the original paper version of the Wyoming Student Atlas was developed using story mapping technology. Studies on best practices for data-driven storytelling and web map interaction were used to inform the transition of the atlas from a traditional paper format to a collection of story maps. Evaluation of the atlas story maps for educational purposes was conducted by observing students from multiple classrooms as they used the story maps in a lesson. The students and educators responded to a survey after using the story maps. Results of the survey show positive responses to the atlas story maps, including ease of use and preference over a traditional paper atlas. However, certain types of interaction with the map resulted in increased negative or uncertain responses from students concerning their perception of the atlas story maps.

  16. Mapping the Obama administration's response to the Arab Spring A evolução da resposta da Administração Obama à Primavera Árabe

    Directory of Open Access Journals (Sweden)

    Maria do Céu de Pinho Ferreira Pinto

    2012-12-01

    Full Text Available When the Arab Spring broke out, the United States was in a quandary over how to handle the crisis in its attempt to balance its moral obligations and ideals without undercutting its strategic interests and those of its close allies. Flaws in US diplomatic approach have contributed to one of the most serious foreign policy crisis for a US administration to date with consequential upheaval and erosion of the US-built balance of power. The reactions and policy responses of the Obama administration highlight the difficulties in grasping with the new reality in the Middle East and in enunciating a policy platform that could combine American interests and values.Quando a Primavera Árabe eclodiu, os Estados Unidos ficaram num dilema sobre como lidar com a crise tentando equilibrar as suas obrigações morais e os ideais sem fragilizar os seus interesses estratégicos e aqueles dos seus aliados mais próximos. A indecisão e as contradições na abordagem diplomática dos EUA contribuíram para avolumar uma das mais graves crises de política externa dos EUA, pondo em perigo a balança de poder que os EUA criaram na região. A reação e a resposta política da administração Obama põe em destaque a dificuldade de Washington em lidar com a nova realidade no Oriente Médio e em enunciar uma plataforma política que possa conciliar os interesses e os valores americanos.

  17. Brain/MINDS: brain-mapping project in Japan

    Science.gov (United States)

    Okano, Hideyuki; Miyawaki, Atsushi; Kasai, Kiyoto

    2015-01-01

    There is an emerging interest in brain-mapping projects in countries across the world, including the USA, Europe, Australia and China. In 2014, Japan started a brain-mapping project called Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS). Brain/MINDS aims to map the structure and function of neuronal circuits to ultimately understand the vast complexity of the human brain, and takes advantage of a unique non-human primate animal model, the common marmoset (Callithrix jacchus). In Brain/MINDS, the RIKEN Brain Science Institute acts as a central institute. The objectives of Brain/MINDS can be categorized into the following three major subject areas: (i) structure and functional mapping of a non-human primate brain (the marmoset brain); (ii) development of innovative neurotechnologies for brain mapping; and (iii) human brain mapping; and clinical research. Brain/MINDS researchers are highly motivated to identify the neuronal circuits responsible for the phenotype of neurological and psychiatric disorders, and to understand the development of these devastating disorders through the integration of these three subject areas. PMID:25823872

  18. Brain/MINDS: brain-mapping project in Japan.

    Science.gov (United States)

    Okano, Hideyuki; Miyawaki, Atsushi; Kasai, Kiyoto

    2015-05-19

    There is an emerging interest in brain-mapping projects in countries across the world, including the USA, Europe, Australia and China. In 2014, Japan started a brain-mapping project called Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS). Brain/MINDS aims to map the structure and function of neuronal circuits to ultimately understand the vast complexity of the human brain, and takes advantage of a unique non-human primate animal model, the common marmoset (Callithrix jacchus). In Brain/MINDS, the RIKEN Brain Science Institute acts as a central institute. The objectives of Brain/MINDS can be categorized into the following three major subject areas: (i) structure and functional mapping of a non-human primate brain (the marmoset brain); (ii) development of innovative neurotechnologies for brain mapping; and (iii) human brain mapping; and clinical research. Brain/MINDS researchers are highly motivated to identify the neuronal circuits responsible for the phenotype of neurological and psychiatric disorders, and to understand the development of these devastating disorders through the integration of these three subject areas.

  19. Personalized 2D color maps

    KAUST Repository

    Waldin, Nicholas

    2016-06-24

    2D color maps are often used to visually encode complex data characteristics such as heat or height. The comprehension of color maps in visualization is affected by the display (e.g., a monitor) and the perceptual abilities of the viewer. In this paper we present a novel method to measure a user\\'s ability to distinguish colors of a two-dimensional color map on a given monitor. We show how to adapt the color map to the user and display to optimally compensate for the measured deficiencies. Furthermore, we improve user acceptance of the calibration procedure by transforming the calibration into a game. The user has to sort colors along a line in a 3D color space in a competitive fashion. The errors the user makes in sorting these lines are used to adapt the color map to his perceptual capabilities.

  20. The National Map 2.0 Tactical Plan: "Toward the (Integrated) National Map"

    Science.gov (United States)

    Zulick, Carl A.

    2008-01-01

    The National Map's 2-year goal, as described in this plan, is to provide a range of geospatial products and services that meet the basic goals of the original vision for The National Map while furthering the National Spatial Data Infrastructure that underpins U.S. Geological Survey (USGS) science. To accomplish this goal, the National Geospatial Program (NGP) will acquire, store, maintain, and distribute base map data. The management team for the NGP sets priorities for The National Map in three areas: Data and Products, Services, and Management. Priorities for fiscal years 2008 and 2009 (October 1, 2007 through September 30, 2009), involving the current data inventory, data acquisition, and the integration of data, are (1) incorporating current data from Federal, State, and local organizations into The National Map to the degree possible, given data availability and program resources; (2) collaborating with other USGS programs to incorporate data that support the USGS Science Strategy; (3) supporting the Department of the Interior (DOI) high-priority geospatial information needs; (4) emergency response; (5) homeland security, natural hazards; and (6) graphics products delivery. The management team identified known constraints, enablers, and drivers for the acquisition and integration of data. The NGP management team also identified customer-focused products and services of The National Map. Ongoing planning and management activities direct the development and delivery of these products and services. Management of work flow processes to support The National Map priorities are identified and established through a business-driven prioritization process. This tactical plan is primarily for use as a document to guide The National Map program for the next two fiscal years. The document is available to the public because of widespread interest in The National Map. The USGS collaborates with a broad range of customers and partners who are essential to the success of The

  1. Macro stress mapping on thin film buckling

    Energy Technology Data Exchange (ETDEWEB)

    Goudeau, P.; Villain, P.; Renault, P.-O.; Tamura, N.; Celestre, R.S.; Padmore, H.A.

    2002-11-06

    Thin films deposited by Physical Vapour Deposition techniques on substrates generally exhibit large residual stresses which may be responsible of thin film buckling in the case of compressive stresses. Since the 80's, a lot of theoretical work has been done to develop mechanical models but only a few experimental work has been done on this subject to support these theoretical approaches and nothing concerning local stress measurement mainly because of the small dimension of the buckling (few 10th mm). This paper deals with the application of micro beam X-ray diffraction available on synchrotron radiation sources for stress mapping analysis of gold thin film buckling.

  2. Online GIS services for mapping and sharing disease information

    DEFF Research Database (Denmark)

    Gao, Sheng; Mioc, Darka; Anton, François

    2008-01-01

    Background Disease data sharing is important for the collaborative preparation, response, and recovery stages of disease control. Disease phenomena are strongly associated with spatial and temporal factors. Web-based Geographical Information Systems provide a real-time and dynamic way to represent...... and responding to disease outbreaks. To overcome these challenges in disease data mapping and sharing, the senior authors have designed an interoperable service oriented architecture based on Open Geospatial Consortium specifications to share the spatio-temporal disease information. Results A case study...... of infectious disease mapping across New Brunswick (Canada) and Maine (USA) was carried out to evaluate the proposed architecture, which uses standard Web Map Service, Styled Layer Descriptor and Web Map Context specifications. The case study shows the effectiveness of an infectious disease surveillance system...

  3. Mapping Nursing Pathways

    Directory of Open Access Journals (Sweden)

    Melanie Birks

    2015-09-01

    Full Text Available Articulated education pathways between the vocational education training sector and universities provide opportunities for students wishing to progress to higher qualifications. Enrolled nurses seeking to advance their career in nursing can choose to enter baccalaureate degree programs through such alternative entry routes. Awarding of credit for prior studies is dependent on accurate assessment of the existing qualification against that which is sought. This study employed a modified Delphi method to inform the development of an evidence-based, structured approach to mapping the pathway from the nationally consistent training package of the Diploma of Nursing to the diversity of baccalaureate nursing programs across Australia. The findings of this study reflect the practical nature of the role of the enrolled nurse, particularly the greater emphasis placed on direct care activities as opposed to those related to professional development and the generation and use of evidence. These findings provide a valuable summative overview of the relationship between the Diploma of Nursing and the expectations of the registered nurse role.

  4. Mapping Earth's electromagnetic dimensionality

    Science.gov (United States)

    Love, J. J.; Kelbert, A.; Bedrosian, P.

    2017-12-01

    The form of a magnetotelluric impedance tensor, obtained for a given geographic site through simultaneous measurement of geomagnetic and geoelectric field variation, is affected by electrical conductivity structure beneath the measurement site. Building on existing methods for characterizing the symmetry of magnetotelluric impedance tensors, a simple scalar measure is developed for measuring the (frequency dependent) proportion of the impedance tensor that is not just a one-dimensional (1D) function of depth ("non-1D-ness"). These measures are applied to nearly 1000 impedance tensors obtained during magnetotelluric surveys, those for the continental United States and obtained principally through the National Science Foundation's EarthScope project. Across geomagnetic/geoelectric variational periods ranging from 30 s to 3,000 s, corresponding to crustal and upper mantle depths, it is shown that local Earth structure is very often not simply 1D-depth-dependent - often less than 50% of magnetotelluric impedance is 1D. For selected variational frequencies, non-1D-ness is mapped and the relationship between electromagnetic dimensionality and known geological and tectonic structures is discussed. The importance of using realistic surface impedances to accurately evaluate magnetic-storm geoelectric hazards is emphasized.

  5. Mapping of repair genes

    International Nuclear Information System (INIS)

    Hori, Tadaaki

    1985-01-01

    Chromosome mapping of repair genes involved in U.V. sensitivity is reported. Twenty-three of 25 hybrid cells were resistant to U.V. light. Survival curves of 2 U.V.-resistant cell strains, which possessed mouse chromosomes and human chromosome No.7 - 16, were similar to those of wild strain (L5178Y). On the other hand, survival curves of U.V.-sensitive hybrid cells was analogous to those of Q31. There was a definitive difference in the frequency of inducible chromosome aberrations between U.V. resistant and sensitive mouse-human hybrid cells. U.V.-resistant cell strains possessed the ability of excision repair. Analysis of karyotype in hybrid cells showed that the difference in U.V. sensitivity is dependent upon whether or not human chromosome No.13 is present. Synteny test on esterase D-determining locus confirmed that there is an agreement between the presence of chromosome No.13 and the presence of human esterase D activity. These results led to a conclusion that human genes which compensate recessive character of U.V.-sensitive mutant strain, Q31, with mouse-human hybrid cells are located on the locus of chromosome No.13. (Namekawa, K.)

  6. ANNUAL INTERVIEWS (MAPS)

    CERN Multimedia

    2003-01-01

    For the performance appraisal of reference year 2003, the interview calendar has been fixed between 1 January and 31 March 2004. This new calendar gives a better time schedule to the supervisors to conduct the interviews. This may also be necessary due to the roles of different supervisors resulting from the particular situations of the new CERN structure as from 2004. With this later time limit, the new departments are invited to strictly respect the target date of 31 March. The report form template is as last year available on the HR Division Website. A banner on the internal homepage: http://cern.ch/hr-div will lead directly to the page with the form. The personal data for the first page of the form can be generated by each divisional hierarchy, by the Divisional Administrative Officer (DAO) or by the staff member himself via HRT. Following discussions about the first two years of MAPS, and in order to improve the performance appraisal process, some modifications have been brought to section 2 (Assessme...

  7. Dedicated Filter for Robust Occupancy Grid Mapping

    Directory of Open Access Journals (Sweden)

    KS Nagla

    2015-03-01

    Full Text Available Sensor based perception of the environment is an emerging area of the mobile robot research where sensors play a pivotal role. For autonomous mobile robots, the fundamental requirement is the convergent of the range information in to high level internal representation. Internal representation in the form of occupancy grid is commonly used in autonomous mobile robots due to its various advantages. There are several sensors such as vision sensor, laser rage finder, and ultrasonic and infrared sensors etc. play roles in mapping. However the sensor information failure, sensor inaccuracies, noise, and slow response are the major causes of an error in the mapping. To improve the reliability of the mobile robot mapping multisensory data fusion is considered as an optimal solution. This paper presents a novel architecture of sensor fusion frame work in which a dedicated filter (DF is proposed to increase the robustness of the occupancy grid for indoor environment. The technique has been experimentally verified for different indoor test environments. The proposed configuration shows improvement in the occupancy grid with the implementation of dedicated filters.

  8. Making maps a visual guide to map design for GIS

    CERN Document Server

    Krygier, John

    2016-01-01

    Lauded for its accessibility and beautiful design, this text has given thousands of students and professionals the tools to create effective, compelling maps. Using a wealth of illustrations--with 74 in full color--to elucidate each concisely presented point, the revised and updated third edition continues to emphasize how design choices relate to the reasons for making a map and its intended purpose. All components of map making are covered: titles, labels, legends, visual hierarchy, font selection, how to turn phenomena into visual data, data organization, symbolization, and more. Innovative

  9. A molecular marker map for roses

    NARCIS (Netherlands)

    Debener, T.; Mattiesch, L.; Vosman, B.

    2001-01-01

    n addition to an existing core map for diploid roses which comprised 305 molecular markers 60 additional markers were mapped to extend the map. As a first application of the information contained in the map, the map position of a resistance gene from roses, Rdr1, was determined by identifying

  10. Planet map generation by tetrahedral subdivision

    DEFF Research Database (Denmark)

    Mogensen, Torben Ægidius

    2010-01-01

    We present a method for generating pseudo-random, zoomable planet maps for games and art.  The method is based on spatial subdivision using tetrahedrons.  This ensures planet maps without discontinuities caused by mapping a flat map onto a sphere. We compare the method to other map...

  11. Association mapping of partitioning loci in barley

    Directory of Open Access Journals (Sweden)

    Mackay Ian J

    2008-02-01

    Full Text Available Abstract Background Association mapping, initially developed in human disease genetics, is now being applied to plant species. The model species Arabidopsis provided some of the first examples of association mapping in plants, identifying previously cloned flowering time genes, despite high population sub-structure. More recently, association genetics has been applied to barley, where breeding activity has resulted in a high degree of population sub-structure. A major genotypic division within barley is that between winter- and spring-sown varieties, which differ in their requirement for vernalization to promote subsequent flowering. To date, all attempts to validate association genetics in barley by identifying major flowering time loci that control vernalization requirement (VRN-H1 and VRN-H2 have failed. Here, we validate the use of association genetics in barley by identifying VRN-H1 and VRN-H2, despite their prominent role in determining population sub-structure. Results By taking barley as a typical inbreeding crop, and seasonal growth habit as a major partitioning phenotype, we develop an association mapping approach which successfully identifies VRN-H1 and VRN-H2, the underlying loci largely responsible for this agronomic division. We find a combination of Structured Association followed by Genomic Control to correct for population structure and inflation of the test statistic, resolved significant associations only with VRN-H1 and the VRN-H2 candidate genes, as well as two genes closely linked to VRN-H1 (HvCSFs1 and HvPHYC. Conclusion We show that, after employing appropriate statistical methods to correct for population sub-structure, the genome-wide partitioning effect of allelic status at VRN-H1 and VRN-H2 does not result in the high levels of spurious association expected to occur in highly structured samples. Furthermore, we demonstrate that both VRN-H1 and the candidate VRN-H2 genes can be identified using association mapping

  12. Strange distributionally chaotic triangular maps

    International Nuclear Information System (INIS)

    Paganoni, L.; Smital, J.

    2005-01-01

    The notion of distributional chaos was introduced by Schweizer, Smital [Measures of chaos and a spectral decompostion of dynamical systems on the interval. Trans. Amer. Math. Soc. 344;1994:737-854] for continuous maps of the interval. For continuous maps of a compact metric space three mutually nonequivalent versions of distributional chaos, DC1-DC3, can be considered. In this paper we study distributional chaos in the class T m of triangular maps of the square which are monotone on the fibres; such maps must have zero topological entropy. The main results: (i) There is an F-bar T m such that F-bar DC2 and F vertical bar Rec(F)-bar DC3. (ii) If no ω-limit set of an F-bar T m contains two minimal subsets then F-bar DC1. This completes recent results obtained by Forti et al. [Dynamics of homeomorphisms on minimal sets generated by triangular mappings. Bull Austral Math Soc 59;1999:1-20], Smital, Stefankova [Distributional chaos for triangular maps, Chaos, Solitons and Fractals 21;2004:1125-8], and Balibrea et al. [The three versions of distributional chaos. Chaos, Solitons and Fractals 23;2005:1581-3]. The paper contributes to the solution of a long-standing open problem by Sharkovsky concerning classification of triangular maps

  13. Topological visual mapping in robotics.

    Science.gov (United States)

    Romero, Anna; Cazorla, Miguel

    2012-08-01

    A key problem in robotics is the construction of a map from its environment. This map could be used in different tasks, like localization, recognition, obstacle avoidance, etc. Besides, the simultaneous location and mapping (SLAM) problem has had a lot of interest in the robotics community. This paper presents a new method for visual mapping, using topological instead of metric information. For that purpose, we propose prior image segmentation into regions in order to group the extracted invariant features in a graph so that each graph defines a single region of the image. Although others methods have been proposed for visual SLAM, our method is complete, in the sense that it makes all the process: it presents a new method for image matching; it defines a way to build the topological map; and it also defines a matching criterion for loop-closing. The matching process will take into account visual features and their structure using the graph transformation matching (GTM) algorithm, which allows us to process the matching and to remove out the outliers. Then, using this image comparison method, we propose an algorithm for constructing topological maps. During the experimentation phase, we will test the robustness of the method and its ability constructing topological maps. We have also introduced new hysteresis behavior in order to solve some problems found building the graph.

  14. c-Jun controls the efficiency of MAP kinase signaling by transcriptional repression of MAP kinase phosphatases

    International Nuclear Information System (INIS)

    Sprowles, Amy; Robinson, Dan; Wu Yimi; Kung, H.-J.; Wisdom, Ron

    2005-01-01

    The mammalian JNK signaling pathway regulates the transcriptional response of cells to environmental stress, including UV irradiation. This signaling pathway is composed of a classical MAP kinase cascade; activation results in phosphorylation of the transcription factor substrates c-Jun and ATF2, and leads to changes in gene expression. The defining components of this pathway are conserved in the fission yeast S. pombe, where the genetic studies have shown that the ability of the JNK homolog Spc1 to be activated in response to UV irradiation is dependent on the presence of the transcription factor substrate Atf1. We have used genetic analysis to define the role of c-Jun in activation of the mammalian JNK signaling pathway. Our results show that optimal activation of JNK requires the presence of its transcription factor substrate c-Jun. Mutational analysis shows that the ability of c-Jun to support efficient activation of JNK requires the ability of Jun to bind DNA, suggesting a transcriptional mechanism. Consistent with this, we show that c-Jun represses the expression of several MAP kinase phosphatases. In the absence of c-Jun, the increased expression of MAP kinase phosphatases leads to impaired activation of the ERK, JNK, and p38 MAP kinases after pathway activation. The results show that one function of c-Jun is to regulate the efficiency of signaling by the ERK, p38, and JNK MAP kinases, a function that is likely to affect cellular responses to many different stimuli

  15. Probabilistic Flood Mapping using Volunteered Geographical Information

    Science.gov (United States)

    Rivera, S. J.; Girons Lopez, M.; Seibert, J.; Minsker, B. S.

    2016-12-01

    Flood extent maps are widely used by decision makers and first responders to provide critical information that prevents economic impacts and the loss of human lives. These maps are usually obtained from sensory data and/or hydrologic models, which often have limited coverage in space and time. Recent developments in social media and communication technology have created a wealth of near-real-time, user-generated content during flood events in many urban areas, such as flooded locations, pictures of flooding extent and height, etc. These data could improve decision-making and response operations as events unfold. However, the integration of these data sources has been limited due to the need for methods that can extract and translate the data into useful information for decision-making. This study presents an approach that uses volunteer geographic information (VGI) and non-traditional data sources (i.e., Twitter, Flicker, YouTube, and 911 and 311 calls) to generate/update the flood extent maps in areas where no models and/or gauge data are operational. The approach combines Web-crawling and computer vision techniques to gather information about the location, extent, and water height of the flood from unstructured textual data, images, and videos. These estimates are then used to provide an updated flood extent map for areas surrounding the geo-coordinate of the VGI through the application of a Hydro Growing Region Algorithm (HGRA). HGRA combines hydrologic and image segmentation concepts to estimate a probabilistic flooding extent along the corresponding creeks. Results obtained for a case study in Austin, TX (i.e., 2015 Memorial Day flood) were comparable to those obtained by a calibrated hydrologic model and had good spatial correlation with flooding extents estimated by the Federal Emergency Management Agency (FEMA).

  16. Angola Seismicity MAP

    Science.gov (United States)

    Neto, F. A. P.; Franca, G.

    2014-12-01

    The purpose of this job was to study and document the Angola natural seismicity, establishment of the first database seismic data to facilitate consultation and search for information on seismic activity in the country. The study was conducted based on query reports produced by National Institute of Meteorology and Geophysics (INAMET) 1968 to 2014 with emphasis to the work presented by Moreira (1968), that defined six seismogenic zones from macro seismic data, with highlighting is Zone of Sá da Bandeira (Lubango)-Chibemba-Oncócua-Iona. This is the most important of Angola seismic zone, covering the epicentral Quihita and Iona regions, geologically characterized by transcontinental structure tectono-magmatic activation of the Mesozoic with the installation of a wide variety of intrusive rocks of ultrabasic-alkaline composition, basic and alkaline, kimberlites and carbonatites, strongly marked by intense tectonism, presenting with several faults and fractures (locally called corredor de Lucapa). The earthquake of May 9, 1948 reached intensity VI on the Mercalli-Sieberg scale (MCS) in the locality of Quihita, and seismic active of Iona January 15, 1964, the main shock hit the grade VI-VII. Although not having significant seismicity rate can not be neglected, the other five zone are: Cassongue-Ganda-Massano de Amorim; Lola-Quilengues-Caluquembe; Gago Coutinho-zone; Cuima-Cachingues-Cambândua; The Upper Zambezi zone. We also analyzed technical reports on the seismicity of the middle Kwanza produced by Hidroproekt (GAMEK) region as well as international seismic bulletins of the International Seismological Centre (ISC), United States Geological Survey (USGS), and these data served for instrumental location of the epicenters. All compiled information made possible the creation of the First datbase of seismic data for Angola, preparing the map of seismicity with the reconfirmation of the main seismic zones defined by Moreira (1968) and the identification of a new seismic

  17. USGS Elevation Contours Overlay Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The USGS Elevation Contours service from The National Map (TNM) consists of contours generated for the conterminous United States from 1- and 1/3 arc-second...

  18. USGS NAIP Imagery Overlay Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The USGS NAIP Imagery service from The National Map (TNM) consists of high resolution images that combine the visual attributes of an aerial photograph with the...

  19. DAWN GRAND MAP CERES HYDROGEN MAP V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — A global map of the concentration of hydrogen within the regolith of asteroid 1 Ceres on twenty-degree quasi-equal-area pixels is provided. Hydrogen concentrations...

  20. Topographical Hill Shading Map Production Based Tianditu (map World)

    Science.gov (United States)

    Wang, C.; Zha, Z.; Tang, D.; Yang, J.

    2018-04-01

    TIANDITU (Map World) is the public version of National Platform for Common Geospatial Information Service, and the terrain service is an important channel for users on the platform. With the development of TIANDITU, topographical hill shading map production for providing and updating global terrain map on line becomes necessary for the characters of strong intuition, three-dimensional sense and aesthetic effect. As such, the terrain service of TIANDITU focuses on displaying the different scales of topographical data globally. And this paper mainly aims to research the method of topographical hill shading map production globally using DEM (Digital Elevation Model) data between the displaying scales about 1 : 140,000,000 to 1 : 4,000,000, corresponded the display level from 2 to 7 on TIANDITU website.

  1. USGS Imagery Topo Base Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — USGS Imagery Topo is a topographic tile cache base map with orthoimagery as a backdrop, and combines the most current data (Boundaries, Names, Transportation,...

  2. USGS Hill Shade Base Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — USGS Hill Shade (or Shaded Relief) is a tile cache base map created from the National Elevation Dataset (NED), a seamless dataset of best available raster elevation...

  3. Neural net generated seismic facies map and attribute facies map

    International Nuclear Information System (INIS)

    Addy, S.K.; Neri, P.

    1998-01-01

    The usefulness of 'seismic facies maps' in the analysis of an Upper Wilcox channel system in a 3-D survey shot by CGG in 1995 in Lavaca county in south Texas was discussed. A neural net-generated seismic facies map is a quick hydrocarbon exploration tool that can be applied regionally as well as on a prospect scale. The new technology is used to classify a constant interval parallel to a horizon in a 3-D seismic volume based on the shape of the wiggle traces using a neural network technology. The tool makes it possible to interpret sedimentary features of a petroleum deposit. The same technology can be used in regional mapping by making 'attribute facies maps' in which various forms of amplitude attributes, phase attributes or frequency attributes can be used

  4. USGS Topo Base Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — USGS Topo is a topographic tile cache base map that combines the most current data (Boundaries, Names, Transportation, Elevation, Hydrography, Land Cover, and other...

  5. USGS NAIPPlus Overlay Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The USGS NAIP Plus service from The National Map consists of National Agriculture Imagery Program (NAIP) and high resolution orthoimagery (HRO) that combine the...

  6. Global trends in satellite-based emergency mapping

    Science.gov (United States)

    Voigt, Stefan; Giulio-Tonolo, Fabio; Lyons, Josh; Kučera, Jan; Jones, Brenda; Schneiderhan, Tobias; Platzeck, Gabriel; Kaku, Kazuya; Hazarika, Manzul Kumar; Czaran, Lorant; Li, Suju; Pedersen, Wendi; James, Godstime Kadiri; Proy, Catherine; Muthike, Denis Macharia; Bequignon, Jerome; Guha-Sapir, Debarati

    2016-01-01

    Over the past 15 years, scientists and disaster responders have increasingly used satellite-based Earth observations for global rapid assessment of disaster situations. We review global trends in satellite rapid response and emergency mapping from 2000 to 2014, analyzing more than 1000 incidents in which satellite monitoring was used for assessing major disaster situations. We provide a synthesis of spatial patterns and temporal trends in global satellite emergency mapping efforts and show that satellite-based emergency mapping is most intensively deployed in Asia and Europe and follows well the geographic, physical, and temporal distributions of global natural disasters. We present an outlook on the future use of Earth observation technology for disaster response and mitigation by putting past and current developments into context and perspective.

  7. Coordinate systems and map projections

    CERN Document Server

    Maling, DH

    1992-01-01

    A revised and expanded new edition of the definitive English work on map projections. The revisions take into account the huge advances in geometrical geodesy which have occurred since the early years of satellite geodesy. The detailed configuration of the geoid resulting from the GEOS and SEASAT altimetry measurements are now taken into consideration. Additionally, the chapter on computation of map projections is updated bearing in mind the availability of pocket calculators and microcomputers. Analytical derivation of some map projections including examples of pseudocylindrical and polyconic

  8. Acid Deposition Maps in Spain

    International Nuclear Information System (INIS)

    Artinano, B.; Cabal, H.; Garcia, C.

    1998-01-01

    Animal and monthly deposition velocity and total sulfur deposition maps have been performed for the peninsular Spain for 1992 by using the inferential method. To do this, updated databases with high space and time resolution, for land uses (CORINE) and meteorological information from analysis modelling for the same year, have been utilized. The final result are deposition maps in a 5x5 Km 2 grid which allow to assess the methodology used in Europe to obtain the maps of excedances over the critical loads of pollutants. (Author) 32 refs

  9. Rapid Recombination Mapping for High-Throughput Genetic Screens in Drosophila

    OpenAIRE

    Sapiro, Anne L.; Ihry, Robert J.; Buhr, Derek L.; Konieczko, Kevin M.; Ives, Sarah M.; Engstrom, Anna K.; Wleklinski, Nicholas P.; Kopish, Kristin J.; Bashirullah, Arash

    2013-01-01

    Mutagenesis screens are a staple of classical genetics. Chemical-induced mutations, however, are often difficult and time-consuming to identify. Here, we report that recombination analysis with pairs of dominant visible markers provides a rapid and reliable strategy to map mutations in Drosophila melanogaster. This method requires only two generations and a total of six crosses in vials to estimate the genetic map position of the responsible lesion with high accuracy. This genetic map positio...

  10. SLAMM: Visual monocular SLAM with continuous mapping using multiple maps.

    Directory of Open Access Journals (Sweden)

    Hayyan Afeef Daoud

    Full Text Available This paper presents the concept of Simultaneous Localization and Multi-Mapping (SLAMM. It is a system that ensures continuous mapping and information preservation despite failures in tracking due to corrupted frames or sensor's malfunction; making it suitable for real-world applications. It works with single or multiple robots. In a single robot scenario the algorithm generates a new map at the time of tracking failure, and later it merges maps at the event of loop closure. Similarly, maps generated from multiple robots are merged without prior knowledge of their relative poses; which makes this algorithm flexible. The system works in real time at frame-rate speed. The proposed approach was tested on the KITTI and TUM RGB-D public datasets and it showed superior results compared to the state-of-the-arts in calibrated visual monocular keyframe-based SLAM. The mean tracking time is around 22 milliseconds. The initialization is twice as fast as it is in ORB-SLAM, and the retrieved map can reach up to 90 percent more in terms of information preservation depending on tracking loss and loop closure events. For the benefit of the community, the source code along with a framework to be run with Bebop drone are made available at https://github.com/hdaoud/ORBSLAMM.

  11. Globally Coupled Chaotic Maps with Constant Force

    International Nuclear Information System (INIS)

    Li Jinghui

    2008-01-01

    We investigate the motion of the globally coupled maps (logistic map) with a constant force. It is shown that the constant force can cause multi-synchronization for the globally coupled chaotic maps studied by us.

  12. Software patterns, knowledge maps, and domain analysis

    CERN Document Server

    Fayad, Mohamed E; Hegde, Srikanth GK; Basia, Anshu; Vakil, Ashka

    2014-01-01

    Preface AcknowledgmentsAuthors INTRODUCTIONAn Overview of Knowledge MapsIntroduction: Key Concepts-Software Stable Models, Knowledge Maps, Pattern Language, Goals, Capabilities (Enduring Business Themes + Business Objects) The Motivation The Problem The Objectives Overview of Software Stability Concepts Overview of Knowledge Maps Pattern Languages versus Knowledge Maps: A Brief ComparisonThe Solution Knowledge Maps Methodology or Concurrent Software Development ModelWhy Knowledge Maps? Research Methodology Undertaken Research Verification and Validation The Stratification of This Book Summary

  13. Radar Mapping of Building Structures Applying Sparse Reconstruction

    NARCIS (Netherlands)

    Tan, R.G.; Wit, J.J.M. de; Rossum, W.L. van

    2012-01-01

    The ability to map building structures at a certain stand-off distance allows intelligence, reconnaissance, and clearance tasks to be performed in a covert way by driving around a building. This will greatly improve security, response time, and reliability of aforementioned tasks. Therefore,

  14. Rating environmental noise on the basis of noise maps

    NARCIS (Netherlands)

    Miedema, H.M.E.; Borst, H.C.

    2006-01-01

    A system that rates noise on the basis of noise maps has been developed which is based on empirical exposure-response relationships, so that effects in the community will be lower if the system gives a better rating. It is consistent with noise metrics and effect endpoint chosen in the EU, i.e., it

  15. FLOODPLAIN MAPPING, White COUNTY, IN

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  16. FLOODPLAIN MAPPING, Greene COUNTY, IN

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  17. Arctic Basemaps In Google Maps

    DEFF Research Database (Denmark)

    Muggah, J.; Mioc, Darka

    2010-01-01

    The Ocean Mapping Group has been collecting data in the Arctic since 2003 and there are approximately 2,000 basemaps. In the current online storage format used by the OMG, it is difficult to view the data and users cannot easily pan and zoom. The purpose of this research is to investigate...... the advantages of the use of Google Maps, to display the OMG's Arctic data. The map should should load the large Artic dataset in a reasonable time. The bathymetric images were created using software in Linux written by the OMG, and a step-by-step process was used to create images from the multibeam data...... collected by the OMG in the Arctic. The website was also created using Linux operating system. The projection needed to be changed from Lambert Conformal Conic (useful at higher Latitudes) to Mercator (used by Google Maps) and the data needed to have a common colour scheme. After creating and testing...

  18. Mapping the Development of Psychology

    OpenAIRE

    Flis, Ivan

    2015-01-01

    An invited presentation I gave at the PSI EGG One-day Conference for Early Career Psychologists in Ireland on my ongoing research of mapping the historical development of psychology through journal text-mining. 

  19. NAIP 2015 Imagery Feedback Map

    Data.gov (United States)

    Farm Service Agency, Department of Agriculture — The NAIP 2015 Imagery Feedback map allows users to make comments and observations about the quality of the 2015 National Agriculture Imagery Program (NAIP)...

  20. FLOODPLAIN MAPPING, LINCOLN COUNTY, AR

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...