WorldWideScience

Sample records for resources 5d enrichment

  1. 5D Modelling: An Efficient Approach for Creating Spatiotemporal Predictive 3D Maps of Large-Scale Cultural Resources

    Science.gov (United States)

    Doulamis, A.; Doulamis, N.; Ioannidis, C.; Chrysouli, C.; Grammalidis, N.; Dimitropoulos, K.; Potsiou, C.; Stathopoulou, E.-K.; Ioannides, M.

    2015-08-01

    Outdoor large-scale cultural sites are mostly sensitive to environmental, natural and human made factors, implying an imminent need for a spatio-temporal assessment to identify regions of potential cultural interest (material degradation, structuring, conservation). On the other hand, in Cultural Heritage research quite different actors are involved (archaeologists, curators, conservators, simple users) each of diverse needs. All these statements advocate that a 5D modelling (3D geometry plus time plus levels of details) is ideally required for preservation and assessment of outdoor large scale cultural sites, which is currently implemented as a simple aggregation of 3D digital models at different time and levels of details. The main bottleneck of such an approach is its complexity, making 5D modelling impossible to be validated in real life conditions. In this paper, a cost effective and affordable framework for 5D modelling is proposed based on a spatial-temporal dependent aggregation of 3D digital models, by incorporating a predictive assessment procedure to indicate which regions (surfaces) of an object should be reconstructed at higher levels of details at next time instances and which at lower ones. In this way, dynamic change history maps are created, indicating spatial probabilities of regions needed further 3D modelling at forthcoming instances. Using these maps, predictive assessment can be made, that is, to localize surfaces within the objects where a high accuracy reconstruction process needs to be activated at the forthcoming time instances. The proposed 5D Digital Cultural Heritage Model (5D-DCHM) is implemented using open interoperable standards based on the CityGML framework, which also allows the description of additional semantic metadata information. Visualization aspects are also supported to allow easy manipulation, interaction and representation of the 5D-DCHM geometry and the respective semantic information. The open source 3DCity

  2. Linking Team Resources to Work-Family Enrichment and Satisfaction

    Science.gov (United States)

    Hunter, Emily M.; Perry, Sara Jansen; Carlson, Dawn S.; Smith, Steven A.

    2010-01-01

    Work-family scholars now recognize the potential positive effects of participation in one life domain (i.e., work or family) on performance in other life domains. We examined how employees might benefit from team resources, which are highly relevant to the modern workplace, in both work and nonwork domains via work-family enrichment. Using the…

  3. Conducting EQ-5D Valuation Studies in Resource-Constrained Countries: The Potential Use of Shrinkage Estimators to Reduce Sample Size.

    Science.gov (United States)

    Chan, Kelvin K W; Xie, Feng; Willan, Andrew R; Pullenayegum, Eleanor M

    2018-01-01

    Resource-constrained countries have difficulty conducting large EQ-5D valuation studies, which limits their ability to conduct cost-utility analyses using a value set specific to their own population. When estimates of similar but related parameters are available, shrinkage estimators reduce uncertainty and yield estimators with smaller mean square error (MSE). We hypothesized that health utilities based on shrinkage estimators can reduce MSE and mean absolute error (MAE) when compared to country-specific health utilities. We conducted a simulation study (1,000 iterations) based on the observed means and standard deviations (or standard errors) of the EQ-5D-3L valuation studies from 14 counties. In each iteration, the simulated data were fitted with the model based on the country-specific functional form of the scoring algorithm to create country-specific health utilities ("naïve" estimators). Shrinkage estimators were calculated based on the empirical Bayes estimation methods. The performance of shrinkage estimators was compared with those of the naïve estimators over a range of different sample sizes based on MSE, MAE, mean bias, standard errors and the width of confidence intervals. The MSE of the shrinkage estimators was smaller than the MSE of the naïve estimators on average, as theoretically predicted. Importantly, the MAE of the shrinkage estimators was also smaller than the MAE of the naïve estimators on average. In addition, the reduction in MSE with the use of shrinkage estimators did not substantially increase bias. The degree of reduction in uncertainty by shrinkage estimators is most apparent in valuation studies with small sample size. Health utilities derived from shrinkage estimation allow valuation studies with small sample size to "borrow strength" from other valuation studies to reduce uncertainty.

  4. Role Resources and Work-Family Enrichment: The Role of Work Engagement

    Science.gov (United States)

    Siu, Oi-ling; Lu, Jia-fang; Brough, Paula; Lu, Chang-qin; Bakker, Arnold B.; Kalliath, Thomas; O'Driscoll, Michael; Phillips, David R.; Chen, Wei-qing; Lo, Danny; Sit, Cindy; Shi, Kan

    2010-01-01

    This article proposes a theoretical model of work-family enrichment and tests the mediating role of work engagement. The inclusion of work engagement extends prior research on work-family interface, and allows for examination of the effects of role resources (job resources, family support) on work-family enrichment. A two-wave survey was conducted…

  5. Enriching a Grammatical Database with Intelligent Links to Linguistic Resources

    NARCIS (Netherlands)

    van der Wouden, Ton; Bouma, G.; van de Camp, Matje; van Koppen, J.M.|info:eu-repo/dai/nl/203188934; Landsbergen, Frank; Odijk, J.E.J.M.|info:eu-repo/dai/nl/082781710

    2016-01-01

    We describe goals and methods of CLARIN-TPC, a project to enrich the on-line Taalportaal (Language Portal) grammatical database with intelligent links in the form of annotated queries to a variety of interfaces to on-line corpora and an on-line linguistic morphophonological database.

  6. Enriched biodiversity data as a resource and service.

    Science.gov (United States)

    Vos, Rutger Aldo; Biserkov, Jordan Valkov; Balech, Bachir; Beard, Niall; Blissett, Matthew; Brenninkmeijer, Christian; van Dooren, Tom; Eades, David; Gosline, George; Groom, Quentin John; Hamann, Thomas D; Hettling, Hannes; Hoehndorf, Robert; Holleman, Ayco; Hovenkamp, Peter; Kelbert, Patricia; King, David; Kirkup, Don; Lammers, Youri; DeMeulemeester, Thibaut; Mietchen, Daniel; Miller, Jeremy A; Mounce, Ross; Nicolson, Nicola; Page, Rod; Pawlik, Aleksandra; Pereira, Serrano; Penev, Lyubomir; Richards, Kevin; Sautter, Guido; Shorthouse, David Peter; Tähtinen, Marko; Weiland, Claus; Williams, Alan R; Sierra, Soraya

    2014-01-01

    Recent years have seen a surge in projects that produce large volumes of structured, machine-readable biodiversity data. To make these data amenable to processing by generic, open source "data enrichment" workflows, they are increasingly being represented in a variety of standards-compliant interchange formats. Here, we report on an initiative in which software developers and taxonomists came together to address the challenges and highlight the opportunities in the enrichment of such biodiversity data by engaging in intensive, collaborative software development: The Biodiversity Data Enrichment Hackathon. The hackathon brought together 37 participants (including developers and taxonomists, i.e. scientific professionals that gather, identify, name and classify species) from 10 countries: Belgium, Bulgaria, Canada, Finland, Germany, Italy, the Netherlands, New Zealand, the UK, and the US. The participants brought expertise in processing structured data, text mining, development of ontologies, digital identification keys, geographic information systems, niche modeling, natural language processing, provenance annotation, semantic integration, taxonomic name resolution, web service interfaces, workflow tools and visualisation. Most use cases and exemplar data were provided by taxonomists. One goal of the meeting was to facilitate re-use and enhancement of biodiversity knowledge by a broad range of stakeholders, such as taxonomists, systematists, ecologists, niche modelers, informaticians and ontologists. The suggested use cases resulted in nine breakout groups addressing three main themes: i) mobilising heritage biodiversity knowledge; ii) formalising and linking concepts; and iii) addressing interoperability between service platforms. Another goal was to further foster a community of experts in biodiversity informatics and to build human links between research projects and institutions, in response to recent calls to further such integration in this research domain

  7. Enriched biodiversity data as a resource and service

    Science.gov (United States)

    Balech, Bachir; Beard, Niall; Blissett, Matthew; Brenninkmeijer, Christian; van Dooren, Tom; Eades, David; Gosline, George; Groom, Quentin John; Hamann, Thomas D.; Hettling, Hannes; Hoehndorf, Robert; Holleman, Ayco; Hovenkamp, Peter; Kelbert, Patricia; King, David; Kirkup, Don; Lammers, Youri; DeMeulemeester, Thibaut; Mietchen, Daniel; Miller, Jeremy A.; Mounce, Ross; Nicolson, Nicola; Page, Rod; Pawlik, Aleksandra; Pereira, Serrano; Penev, Lyubomir; Richards, Kevin; Sautter, Guido; Shorthouse, David Peter; Tähtinen, Marko; Weiland, Claus; Williams, Alan R.; Sierra, Soraya

    2014-01-01

    Abstract Background: Recent years have seen a surge in projects that produce large volumes of structured, machine-readable biodiversity data. To make these data amenable to processing by generic, open source “data enrichment” workflows, they are increasingly being represented in a variety of standards-compliant interchange formats. Here, we report on an initiative in which software developers and taxonomists came together to address the challenges and highlight the opportunities in the enrichment of such biodiversity data by engaging in intensive, collaborative software development: The Biodiversity Data Enrichment Hackathon. Results: The hackathon brought together 37 participants (including developers and taxonomists, i.e. scientific professionals that gather, identify, name and classify species) from 10 countries: Belgium, Bulgaria, Canada, Finland, Germany, Italy, the Netherlands, New Zealand, the UK, and the US. The participants brought expertise in processing structured data, text mining, development of ontologies, digital identification keys, geographic information systems, niche modeling, natural language processing, provenance annotation, semantic integration, taxonomic name resolution, web service interfaces, workflow tools and visualisation. Most use cases and exemplar data were provided by taxonomists. One goal of the meeting was to facilitate re-use and enhancement of biodiversity knowledge by a broad range of stakeholders, such as taxonomists, systematists, ecologists, niche modelers, informaticians and ontologists. The suggested use cases resulted in nine breakout groups addressing three main themes: i) mobilising heritage biodiversity knowledge; ii) formalising and linking concepts; and iii) addressing interoperability between service platforms. Another goal was to further foster a community of experts in biodiversity informatics and to build human links between research projects and institutions, in response to recent calls to further such

  8. Enriched biodiversity data as a resource and service

    Directory of Open Access Journals (Sweden)

    Rutger Vos

    2014-06-01

    Full Text Available Background: Recent years have seen a surge in projects that produce large volumes of structured, machine-readable biodiversity data. To make these data amenable to processing by generic, open source “data enrichment” workflows, they are increasingly being represented in a variety of standards-compliant interchange formats. Here, we report on an initiative in which software developers and taxonomists came together to address the challenges and highlight the opportunities in the enrichment of such biodiversity data by engaging in intensive, collaborative software development: The Biodiversity Data Enrichment Hackathon. Results: The hackathon brought together 37 participants (including developers and taxonomists, i.e. scientific professionals that gather, identify, name and classify species from 10 countries: Belgium, Bulgaria, Canada, Finland, Germany, Italy, the Netherlands, New Zealand, the UK, and the US. The participants brought expertise in processing structured data, text mining, development of ontologies, digital identification keys, geographic information systems, niche modeling, natural language processing, provenance annotation, semantic integration, taxonomic name resolution, web service interfaces, workflow tools and visualisation. Most use cases and exemplar data were provided by taxonomists. One goal of the meeting was to facilitate re-use and enhancement of biodiversity knowledge by a broad range of stakeholders, such as taxonomists, systematists, ecologists, niche modelers, informaticians and ontologists. The suggested use cases resulted in nine breakout groups addressing three main themes: i mobilising heritage biodiversity knowledge; ii formalising and linking concepts; and iii addressing interoperability between service platforms. Another goal was to further foster a community of experts in biodiversity informatics and to build human links between research projects and institutions, in response to recent calls to further

  9. Is it possible to enrich ontologies with a specialized domain linguistic resource?

    OpenAIRE

    Barrios, MA.; Vilches-Blázquez, LM.

    2010-01-01

    Enriching ontologies with linguistic resources is considered an important target in natural language applications. These linguistic resources should contain not only linguistic but knowledge information. However the linguistic resources available, such as WordNet, are built around lexical relations such as synonymy, antonym, hyponymy, etc. and they do not provide enough information for ontology building. On the other hand, ontologies building requires deeper and more accurate knowledge than g...

  10. The role of personal and key resources in the family-to-work enrichment process.

    Science.gov (United States)

    Tement, Sara

    2014-10-01

    Based on the work-home resources model, the aim of the present research was to test a process model of family-to-work enrichment by examining whether self-efficacy (i.e., personal resource) mediates the relationship between support from one's family and work engagement. Further, it was assumed that positive affectivity (i.e., key resource) moderates the relation between family support and self-efficacy. Using an occupationally heterogeneous sample of Slovenian employees (n = 738), we found support for a mediating effect of self-efficacy as well as for the moderating role of positive affectivity. In general, our results broaden the understanding of work-family enrichment processes and provide support for the work-home resources model. In addition, they point to the relevant role of personal and key resources in work-family interactions. © 2014 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

  11. Advances in industrial prospective of cellulosic macromolecules enriched banana biofibre resources: A review.

    Science.gov (United States)

    Pappu, Asokan; Patil, Vikas; Jain, Sonal; Mahindrakar, Amit; Haque, Ruhi; Thakur, Vijay Kumar

    2015-08-01

    Biological macromolecules enriched resources are rapidly emerging as sustainable, cost effective and environmental friendly materials for several industrial applications. Among different biological macromolecules enriched resources, banana fibres are one of the unexplored high potential bio-resources. Compared to various natural fibres such as jute, coir, palm etc., the banana fibres exhibits a better tensile strength i.e. 458 MPa with 17.14 GPa tensile modulus. Traditionally used petroleum based synthetic fibres have been proven to be toxic, non-biodegradable and energy intensive for manufacturing. Cellulosic banana fibres are potential engineering materials having considerable scope to be used as an environmental friendly reinforcing element for manufacturing of polymer based green materials. This paper summarizes the world scenario of current production of biological macromolecules rich banana residues and fibres; major user's of banana fibres. The quality and quantity of biological macromolecules especially the cellulose, hemicellulose, lignin, wax, engineering and mechanical properties of banana biofibre resources are reported and discussed. Subsequently, the findings of the recent research on bio resource composites, materials performance and opportunities have been discussed which would be a real challenge for the tomorrow world to enhance the livelihood environmental friendly advancement. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. The effects of resource enrichment, dispersal, and predation on local and metacommunity structure.

    Science.gov (United States)

    Cadotte, Marc W; Fortner, Allison M; Fukami, Tadashi

    2006-08-01

    Community structure is the observable outcome of numerous processes. We conducted a laboratory experiment using a microbial model system to disentangle effects of nutrient enrichment, dispersal, and predation on prey species richness and predator abundance at local and metacommunity scales. Prey species included: Chilomonas sp., Colpidium striatum, Colpoda cucullus, Paramecium tetraurelia, P. caudatum, Philodina sp., Spirostomum sp., Tetrahymena thermophila, and Uronema sp., and Stentor coeruleus was the predator used. We hypothesized that: (1) increased basal resources should maintain greater species richness and higher predator abundance; (2) dispersal should maintain greater species richness; and (3) predation should reduce species richness, especially in the high resource treatments relative to no-predator treatments. Our results support all three hypotheses. Further, we show that dispersal affects richness at the local community scale but not at the metacommunity scale. However, predation seems to have major effects at both the local and metacommunity scale. Overall, our results show that effects of resource enrichment, dispersal, and predation were mostly additive rather than interactive, indicating that it may be sometimes easier to understand their effects than generally thought due to complex interactive effects.

  13. Enriching Genomic Resources and Marker Development from Transcript Sequences of Jatropha curcas for Microgravity Studies

    Directory of Open Access Journals (Sweden)

    Wenlan Tian

    2017-01-01

    Full Text Available Jatropha (Jatropha curcas L. is an economically important species with a great potential for biodiesel production. To enrich the jatropha genomic databases and resources for microgravity studies, we sequenced and annotated the transcriptome of jatropha and developed SSR and SNP markers from the transcriptome sequences. In total 1,714,433 raw reads with an average length of 441.2 nucleotides were generated. De novo assembling and clustering resulted in 115,611 uniquely assembled sequences (UASs including 21,418 full-length cDNAs and 23,264 new jatropha transcript sequences. The whole set of UASs were fully annotated, out of which 59,903 (51.81% were assigned with gene ontology (GO term, 12,584 (10.88% had orthologs in Eukaryotic Orthologous Groups (KOG, and 8,822 (7.63% were mapped to 317 pathways in six different categories in Kyoto Encyclopedia of Genes and Genome (KEGG database, and it contained 3,588 putative transcription factors. From the UASs, 9,798 SSRs were discovered with AG/CT as the most frequent (45.8% SSR motif type. Further 38,693 SNPs were detected and 7,584 remained after filtering. This UAS set has enriched the current jatropha genomic databases and provided a large number of genetic markers, which can facilitate jatropha genetic improvement and many other genetic and biological studies.

  14. Enriching Genomic Resources and Marker Development from Transcript Sequences of Jatropha curcas for Microgravity Studies

    Science.gov (United States)

    Tian, Wenlan; Paudel, Dev

    2017-01-01

    Jatropha (Jatropha curcas L.) is an economically important species with a great potential for biodiesel production. To enrich the jatropha genomic databases and resources for microgravity studies, we sequenced and annotated the transcriptome of jatropha and developed SSR and SNP markers from the transcriptome sequences. In total 1,714,433 raw reads with an average length of 441.2 nucleotides were generated. De novo assembling and clustering resulted in 115,611 uniquely assembled sequences (UASs) including 21,418 full-length cDNAs and 23,264 new jatropha transcript sequences. The whole set of UASs were fully annotated, out of which 59,903 (51.81%) were assigned with gene ontology (GO) term, 12,584 (10.88%) had orthologs in Eukaryotic Orthologous Groups (KOG), and 8,822 (7.63%) were mapped to 317 pathways in six different categories in Kyoto Encyclopedia of Genes and Genome (KEGG) database, and it contained 3,588 putative transcription factors. From the UASs, 9,798 SSRs were discovered with AG/CT as the most frequent (45.8%) SSR motif type. Further 38,693 SNPs were detected and 7,584 remained after filtering. This UAS set has enriched the current jatropha genomic databases and provided a large number of genetic markers, which can facilitate jatropha genetic improvement and many other genetic and biological studies. PMID:28154822

  15. Double-Sided 2.5D Graphics.

    Science.gov (United States)

    Yeh, Chih-Kuo; Song, Peng; Lin, Peng-Yen; Fu, Chi-Wing; Lin, Chao-Hung; Lee, Tong-Yee

    2013-02-01

    This paper introduces double-sided 2.5D graphics, aiming at enriching the visual appearance when manipulating conventional 2D graphical objects in 2.5D worlds. By attaching a back texture image on a single-sided 2D graphical object, we can enrich the surface and texture detail on 2D graphical objects and improve our visual experience when manipulating and animating them. A family of novel operations on 2.5D graphics, including rolling, twisting, and folding, are proposed in this work, allowing users to efficiently create compelling 2.5D visual effects. Very little effort is needed from the user's side. In our experiment, various creative designs on double-sided graphics were worked out by the recruited participants including a professional artist, which show and demonstrate the feasibility and applicability of our proposed method.

  16. A Technology Based Program That Matches Enrichment Resources With Student Strengths

    Directory of Open Access Journals (Sweden)

    J.S. Renzulli

    2007-09-01

    Full Text Available Remarkable advances in instructionalcommunication technology (ICT have now made ispossible to provide high levels of enrichment and thekinds of curricular differentiation that facilitateadvanced learning services to students who have accessto a computer and the Internet. But in order tomaximize the potential if ICT it is necessary to constructprograms that are based on learning theory that goesbeyond the didactic and prescriptive models that haveresulted in too much worksheets-on-line and electronicencyclopedias. The Renzulli Learning System (RLSuses a strength-based learning theory called theEnrichment Triad Model that is purposefully designedto promote advanced level learning, creativeproductivity, and high levels of student engagement byfocusing on the application of knowledge rather than themere acquisition and storage of information.The Renzulli Learning System is acomprehensive program that begins by providing acomputer-generated profile of each student’s academicstrengths, interests, learning styles, and preferred modesof expression. A search engine then matches Internetresources to the student’s profile from fourteen carefullyscreened data bases that are categorized by subject area,grade level, state curricular standards, and degree ofcomplexity. There are also hundreds of enrichmentactivities that can be down loaded and reproduced forindividual or group learning activities. A managementsystem called the Wizard Project Maker guides studentsin the application of knowledge to teacher or studentselected assignments, independent research studies, orcreative projects that individuals or small groups wouldlike to pursue. Students and teachers can evaluate thequality of students’ products using a rubric called TheStudent Product Assessment Form. Students can rateeach site visited, conduct a self-assessment of what theyhave gained from the site, and place resources in theirown Total talent Portfolio for future use. RLS alsoincludes a

  17. 2.5D Animacija

    OpenAIRE

    Rođak, Bruno

    2016-01-01

    Tema ovog rada je 2.5D animacija i primjena te tehnike animiranja pri izradi kratkometražnog animiranog filma. Kroz pisani dio ovog rada pokrivaju se svi koraci uključeni u izradu animiranog filma. Obrada se pažnja na korake tog procesa raširene kroz pretprodukciju, produkciju i postprodukciju. Realizacija praktičnog djela rada je napravljena pomodu programa Adobe After Effects, Adobe Photoshop-a, Blendera i Adobe Premiera Pro. Realizacija kroz navedene programe de bit detaljno opisana korak ...

  18. Exterior egg quality as affected by enrichment resources layout in furnished laying-hen cages.

    Science.gov (United States)

    Li, Xiang; Chen, Donghua; Meng, Fanyu; Su, Yingying; Wang, Lisha; Zhang, Runxiang; Li, Jianhong; Bao, Jun

    2017-10-01

    This study aimed to investigate the effects of enrichment resources (a perch, dustbath, and nest) layout in furnished laying-hen cages (FC) on exterior quality of eggs. One hundred and sixty-eight (168) Hy-Line Brown laying hens at 16 weeks of age were randomly distributed to four treatments: small furnished cages (SFC), medium furnished cages type I (MFC-I), medium furnished cages type II (MFC-II), and medium furnished cages type III (MFC-III). Each treatment had 4 replicates or cages with 6 hens for SFC (24 birds for each SFC) and 12 hen/cage for MFC-I, -II, and -III (48 birds for each MFC-I, -II and -III). Following a 2-week acclimation, data collection started at 18 weeks of age and continued till 52 weeks of age. Dirtiness of egg surface or cracked shell as indicators of the exterior egg quality were recorded each week. The results showed that the proportion of cracked or dirty eggs was significantly affected by the FC type (p<0.01) in that the highest proportion of cracked or dirty eggs was found in MFC-I and the lowest proportion of dirty eggs in SFC. The results of this showed that furnished cage types affected both dirty eggs and cracked eggs (p<0.01). The results also indicated that not nest but dustbath lead to more dirty eggs. Only MFC-I had higher dirty eggs at nest than other FC (p< 0.01). The results of dirty eggs in MFC-I and MFC-II compared with SFC and MFC-III seemed suggest that a low position of dustbath led to more dirty eggs. SFC design affected exterior egg quality and the low position of dustbath in FC resulted in higher proportion of dirty eggs.

  19. Exterior egg quality as affected by enrichment resources layout in furnished laying-hen cages

    Directory of Open Access Journals (Sweden)

    Xiang Li

    2017-10-01

    Full Text Available Objective This study aimed to investigate the effects of enrichment resources (a perch, dustbath, and nest layout in furnished laying-hen cages (FC on exterior quality of eggs. Methods One hundred and sixty-eight (168 Hy-Line Brown laying hens at 16 weeks of age were randomly distributed to four treatments: small furnished cages (SFC, medium furnished cages type I (MFC-I, medium furnished cages type II (MFC-II, and medium furnished cages type III (MFC-III. Each treatment had 4 replicates or cages with 6 hens for SFC (24 birds for each SFC and 12 hen/cage for MFC-I, -II, and -III (48 birds for each MFC-I, -II and -III. Following a 2-week acclimation, data collection started at 18 weeks of age and continued till 52 weeks of age. Dirtiness of egg surface or cracked shell as indicators of the exterior egg quality were recorded each week. Results The results showed that the proportion of cracked or dirty eggs was significantly affected by the FC type (p<0.01 in that the highest proportion of cracked or dirty eggs was found in MFC-I and the lowest proportion of dirty eggs in SFC. The results of this showed that furnished cage types affected both dirty eggs and cracked eggs (p<0.01. The results also indicated that not nest but dustbath lead to more dirty eggs. Only MFC-I had higher dirty eggs at nest than other FC (p< 0.01. The results of dirty eggs in MFC-I and MFC-II compared with SFC and MFC-III seemed suggest that a low position of dustbath led to more dirty eggs. Conclusion SFC design affected exterior egg quality and the low position of dustbath in FC resulted in higher proportion of dirty eggs.

  20. Exterior egg quality as affected by enrichment resources layout in furnished laying-hen cages

    Science.gov (United States)

    Li, Xiang; Chen, Donghua; Meng, Fanyu; Su, Yingying; Wang, Lisha; Zhang, Runxiang; Li, Jianhong; Bao, Jun

    2017-01-01

    Objective This study aimed to investigate the effects of enrichment resources (a perch, dustbath, and nest) layout in furnished laying-hen cages (FC) on exterior quality of eggs. Methods One hundred and sixty-eight (168) Hy-Line Brown laying hens at 16 weeks of age were randomly distributed to four treatments: small furnished cages (SFC), medium furnished cages type I (MFC-I), medium furnished cages type II (MFC-II), and medium furnished cages type III (MFC-III). Each treatment had 4 replicates or cages with 6 hens for SFC (24 birds for each SFC) and 12 hen/cage for MFC-I, -II, and -III (48 birds for each MFC-I, -II and -III). Following a 2-week acclimation, data collection started at 18 weeks of age and continued till 52 weeks of age. Dirtiness of egg surface or cracked shell as indicators of the exterior egg quality were recorded each week. Results The results showed that the proportion of cracked or dirty eggs was significantly affected by the FC type (p<0.01) in that the highest proportion of cracked or dirty eggs was found in MFC-I and the lowest proportion of dirty eggs in SFC. The results of this showed that furnished cage types affected both dirty eggs and cracked eggs (p<0.01). The results also indicated that not nest but dustbath lead to more dirty eggs. Only MFC-I had higher dirty eggs at nest than other FC (p< 0.01). The results of dirty eggs in MFC-I and MFC-II compared with SFC and MFC-III seemed suggest that a low position of dustbath led to more dirty eggs. Conclusion SFC design affected exterior egg quality and the low position of dustbath in FC resulted in higher proportion of dirty eggs. PMID:28231694

  1. Enriching enterprise resource planning systems for strategic advantage: a semiotic motivated approach\\ud

    OpenAIRE

    Benfell, Adrian James; Williams, Roy; Liu, Kecheng

    2013-01-01

    Enterprise Resource Planning is often endorsed as a means to facilitate strategic advantage for businesses. The scarcity of resources is the method by which some businesses maintain their position. However, the ubiquitous trend towards the adoption of Enterprise Resourcing Planning systems coupled with market saturation makes the promise of advantage less compelling. Reported in this paper is a proposed solution based upon semiotic theory that takes a typical Enterprise Resource Planning depl...

  2. EQ-5D Portuguese population norms.

    Science.gov (United States)

    Ferreira, Lara Noronha; Ferreira, Pedro L; Pereira, Luis N; Oppe, Mark

    2014-03-01

    The EQ-5D is a widely used preference-based measure. Normative data can be used as references to analyze the effects of healthcare, determine the burden of disease and enable regional or country comparisons. Population norms for the EQ-5D exist for other countries but have not been previously published for Portugal. The purpose of this study was to derive EQ-5D Portuguese population norms. The EQ-5D was applied by phone interview to a random sample of the Portuguese general population (n = 1,500) stratified by age, gender and region. The Portuguese value set was used to derive the EQ-5D index. Mean values were computed by gender and age groups, marital status, educational attainment, region and other variables to obtain the EQ-5D Portuguese norms. Health status declines with advancing age, and women reported worse health status than men. These results are similar to other EQ-5D population health studies. This study provides Portuguese population health-related quality of life data measured by the EQ-5D that can be used as population norms. These norms can be used to inform Portuguese policy makers, health care professionals and researchers in issues related to health care policy and planning and quantification of treatment effects on health status.

  3. Nucleon form factors from 5D skyrmions

    Energy Technology Data Exchange (ETDEWEB)

    Panico, Giuliano [Bethe Center for Theoretical Physics and Physikalisches Institut der Universitaet Bonn, Nussallee 12, 53115 Bonn (Germany); Wulzer, Andrea [Institut de Theorie des Phenomenes Physiques, EPFL, CH-1015 Lausanne (Switzerland)], E-mail: andrea.wulzer@epfl.ch

    2009-06-15

    Several aspects of hadron physics are well described by a simple 5D effective field theory. Baryons arise in this scenario as 'large' (and therefore calculable) 5D skyrmions. We extend and refine the existing analysis of this 5D soliton, which is fairly non-trivial due to the need of numerical methods. We perform the complete quantization of those collective coordinates which are relevant for computing the static observables like the nucleon form factors. We compare the result with simple expectations about large-N{sub c} QCD and with the experimental data. An agreement within 30% is found.

  4. Using museum resources to enrich urban science education: Teacher agency, identity transformation, and Creolized sciences

    Science.gov (United States)

    Adams, Jennifer D.

    This dissertation is a critical ethnography that documented my experience with a group of seven teachers re/producing a leadership identity and building a culture around using museum-based resources to teach science. These teachers were participants in the Urban Advantage initiative---a New York City-wide partnership for science education. The initiative aimed to create a sustainable practice of middle school students and teachers using the City's museums, zoos and botanical gardens to teach science and complete an independent science investigation called the 8th grade Exit Project. The seven teachers formed the core of a group called the Urban Advantage Lead Teachers with the goal creating enactment structures for teachers to effectively use museum resources to teach science. Out of this group one emerged as my case study. I visited her school and examined how she transformed the structure of her school and classroom to include object/inquiry-based science. As a facilitator of the group, I was a participant/observer and my data sources included fieldnotes, individual|collective created artifacts, photographs, videotapes and audiotapes.

  5. Resources

    Science.gov (United States)

    ... disease - resources Hemophilia - resources Herpes - resources Incest - resources Incontinence - resources Infertility - resources Interstitial cystitis - resources Kidney disease - resources Leukemia - resources Liver disease - resources Loss ...

  6. Work-family conflict and enrichment from the perspective of psychosocial resources: comparing Finnish healthcare workers by working schedules.

    Science.gov (United States)

    Mauno, Saija; Ruokolainen, Mervi; Kinnunen, Ulla

    2015-05-01

    We examined work-family conflict (WFC) and work-family enrichment (WFE) by comparing Finnish nurses, working dayshifts (non-shiftworkers, n = 874) and non-dayshifts. The non-dayshift employees worked either two different dayshifts (2-shiftworkers, n = 490) or three different shifts including nightshifts (3-shiftworkers, n = 270). Specifically, we investigated whether different resources, i.e. job control, managers' work-family support, co-workers' work-family support, control at home, personal coping strategies, and schedule satisfaction, predicted differently WFC and WFE in these three groups. Results showed that lower managers' work-family support predicted higher WFC only among 3-shiftworkers, whereas lower co-workers' support associated with increased WFC only in non-shiftworkers. In addition, shiftworkers reported higher WFC than non-shiftworkers. However, the level of WFE did not vary by schedule types. Moreover, the predictors of WFE varied only very little across schedule types. Shiftwork organizations should pay more attention to family-friendly management in order to reduce WFC among shiftworkers. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  7. Organizational work-family resources as predictors of job performance and attitudes: the process of work-family conflict and enrichment.

    Science.gov (United States)

    Odle-Dusseau, Heather N; Britt, Thomas W; Greene-Shortridge, Tiffany M

    2012-01-01

    The goal of the current study was to test a model where organizational resources (aimed at managing work and family responsibilities) predict job attitudes and supervisor ratings of performance through the mechanisms of work-family conflict and work-family enrichment. Employees (n = 174) at a large metropolitan hospital were surveyed at two time periods regarding perceptions of family supportive supervisor behaviors (FSSB), family supportive organizational perceptions (FSOP), bidirectional work-family conflict, bidirectional work-family enrichment, and job attitudes. Supervisors were also asked to provide performance ratings at Time 2. Results revealed FSSB at Time 1 predicted job satisfaction, organizational commitment and intention to leave, as well as supervisor ratings of performance, at Time 2. In addition, both work-family enrichment and family-work enrichment were found to mediate relationships between FSSB and various organizational outcomes, while work-family conflict was not a significant mediator. Results support further testing of supervisor behaviors specific to family support, as well models that include bidirectional work-family enrichment as the mechanism by which work-family resources predict employee and organizational outcomes.

  8. Comparing responsiveness of the EQ-5D-5L, EQ-5D-3L and EQ VAS in stroke patients

    NARCIS (Netherlands)

    D. Golicki (Dominik); M. Niewada (Maciej); A. Karlińska (Anna); J. Buczek (Julia); A. Kobayashi (Adam); M.F. Janssen (Bas); A.S. Pickard (Simon)

    2015-01-01

    textabstractAims: To date, evidence to support the construct validity of the EQ-5D-5L has primarily focused on cross-sectional data. The aims of this study were to examine the responsiveness of EQ-5D-5L in patients with stroke and to compare it with responsiveness of EQ-5D-3L and visual analogue

  9. Outreach and Engagement Education for Graduate Students in Natural Resources: Developing a Course to Enrich a Graduate Outreach Requirement

    Science.gov (United States)

    Latimore, Jo A.; Dreelin, Erin A.; Burroughs, Jordan Pusateri

    2014-01-01

    Scientists need to engage stakeholders in natural resource management; however, few graduate programs prepare students to conduct outreach and engagement. Given this need, the authors' goals were to (1) create a one-credit course that introduced outreach and engagement practices and participatory approaches, (2) improve the quality of graduate…

  10. Enriching the Description of Learning Resources on Disaster Risk Reduction in the Agricultural Domain: An Ontological Approach

    Science.gov (United States)

    Zschocke, Thomas; Villagrán de León, Juan Carlos; Beniest, Jan

    The collection, compilation and dissemination of relevant information and knowledge about the risk of natural disasters is a critical element in the Hyogo Framework for Action 2005-2015 for disaster risk reduction. Knowledge, innovation and education are needed not only to build a culture of safety and resilience at all levels, but also to mainstream disaster risk reduction especially in weather and climate-sensitive sectors such as agriculture. Describing learning resources about these topics with semantic metadata enhances their availability and further facilitates the search and retrieval process by using richer annotations based on ontologies. This paper reports about ongoing work concerning the creation of a domain ontology based on AGROVOC as well as the UN/ISDR and related terminology on disaster risk reduction for the description of associated learning resources in the agricultural domain.

  11. Improved detection of Burkholderia pseudomallei from non-blood clinical specimens using enrichment culture and PCR: narrowing diagnostic gap in resource-constrained settings.

    Science.gov (United States)

    Tellapragada, Chaitanya; Shaw, Tushar; D'Souza, Annet; Eshwara, Vandana Kalwaje; Mukhopadhyay, Chiranjay

    2017-07-01

    To evaluate the diagnostic utility of enrichment culture and PCR for improved case detection rates of non-bacteraemic form of melioidosis in limited resource settings. Clinical specimens (n = 525) obtained from patients presenting at a tertiary care hospital of South India with clinical symptoms suggestive of community-acquired pneumonia, lower respiratory tract infections, superficial or internal abscesses, chronic skin ulcers and bone or joint infections were tested for the presence of Burkholderia pseudomallei using conventional culture (CC), enrichment culture (EC) and PCR. Sensitivity, specificity, positive and negative predictive values of CC and PCR were initially deduced using EC as the gold standard method. Further, diagnostic accuracies of all the three methods were analysed using Bayesian latent class modelling (BLCM). Detection rates of B. pseudomallei using CC, EC and PCR were 3.8%, 5.3% and 6%, respectively. Diagnostic sensitivities and specificities of CC and PCR were 71.4, 98.4% and 100 and 99.4%, respectively in comparison with EC as the gold standard test. With Bayesian latent class modelling, EC and PCR demonstrated sensitivities of 98.7 and 99.3%, respectively, while CC showed a sensitivity of 70.3% for detection of B. pseudomallei. An increase of 1.6% (95% CI: 1.08-4.32%) in the case detection rate of melioidosis was observed in the study population when EC and/or PCR were used in adjunct to the conventional culture technique. Our study findings underscore the diagnostic superiority of enrichment culture and/or PCR over conventional microbiological culture for improved case detection of melioidosis from non-blood clinical specimens. © 2017 John Wiley & Sons Ltd.

  12. Discrete θ and the 5d superconformal index

    Energy Technology Data Exchange (ETDEWEB)

    Bergman, Oren [Department of Physics, Technion, Israel Institute of Technology,Haifa, 32000 (Israel); Rodríguez-Gómez, Diego [Department of Physics, Universidad de Oviedo,Avda. Calvo Sotelo 18, 33007, Oviedo (Spain); Zafrir, Gabi [Department of Physics, Technion, Israel Institute of Technology,Haifa, 32000 (Israel)

    2014-01-16

    5d Yang-Mills theory with an Sp(N) gauge group admits a discrete analog of the θ parameter. We describe the origin of this parameter in N=1 theories from Type I’ string theory, and study its effect on the 5d superconformal fixed point theories with an Sp(1)=SU(2) gauge group by computing the superconformal index. Our result confirms the lack of global symmetry enhancement in the so-called E-tilde{sub 1} theory.

  13. Comparing responsiveness of the EQ-5D-5L, EQ-5D-3L and EQ VAS in stroke patients.

    Science.gov (United States)

    Golicki, Dominik; Niewada, Maciej; Karlińska, Anna; Buczek, Julia; Kobayashi, Adam; Janssen, M F; Pickard, A Simon

    2015-06-01

    To date, evidence to support the construct validity of the EQ-5D-5L has primarily focused on cross-sectional data. The aims of this study were to examine the responsiveness of EQ-5D-5L in patients with stroke and to compare it with responsiveness of EQ-5D-3L and visual analogue scale (EQ VAS). We performed an observational longitudinal cohort study of patients with stroke. At 1 week and 4 months post-stroke, patients were assessed with modified Rankin Scale (mRS) and Barthel Index (BI) and were administered the EQ-5D-5L and EQ-5D-3L, including the EQ VAS. The EQ-5D-5L index scores were derived using the crosswalk methodology developed by the EuroQol Group. We classified patients according to two external criteria, based on mRS or BI, into 3 categories: 'improvement,' 'stable' or 'deterioration'. We assessed the responsiveness of each measure in each patient subgroup using: effect size (ES), standardized response mean (SRM), F-statistic, relative efficiency and area under the receiver operating characteristic curve. A total of 112 patients (52% females; mean age 70.6 years; 93% ischemic stroke) completed all the instruments at both occasions. In subjects with clinical improvement, EQ-5D-5L was consistently responsive, showing moderate ES (0.51-0.71) and moderate to large SRM (0.69-0.86). In general, EQ-5D-3L index appeared to be more responsive (ES 0.63-0.82; SRM 0.77-1.06) and EQ VAS less responsive (ES 0.51-0.65; SRM 0.59-0.69) than EQ-5D-5L index. The EQ-5D-5L index, based on the crosswalk value set, seems to be appropriately responsive in patients with stroke, 4 months after disease onset. As far as EQ-5D-5L index is scored according to crosswalk approach, the EQ-5D-3L index appears to be more responsive in stroke population.

  14. 5-D interpolation with wave-front attributes

    Science.gov (United States)

    Xie, Yujiang; Gajewski, Dirk

    2017-11-01

    Most 5-D interpolation and regularization techniques reconstruct the missing data in the frequency domain by using mathematical transforms. An alternative type of interpolation methods uses wave-front attributes, that is, quantities with a specific physical meaning like the angle of emergence and wave-front curvatures. In these attributes structural information of subsurface features like dip and strike of a reflector are included. These wave-front attributes work on 5-D data space (e.g. common-midpoint coordinates in x and y, offset, azimuth and time), leading to a 5-D interpolation technique. Since the process is based on stacking next to the interpolation a pre-stack data enhancement is achieved, improving the signal-to-noise ratio (S/N) of interpolated and recorded traces. The wave-front attributes are determined in a data-driven fashion, for example, with the Common Reflection Surface (CRS method). As one of the wave-front-attribute-based interpolation techniques, the 3-D partial CRS method was proposed to enhance the quality of 3-D pre-stack data with low S/N. In the past work on 3-D partial stacks, two potential problems were still unsolved. For high-quality wave-front attributes, we suggest a global optimization strategy instead of the so far used pragmatic search approach. In previous works, the interpolation of 3-D data was performed along a specific azimuth which is acceptable for narrow azimuth acquisition but does not exploit the potential of wide-, rich- or full-azimuth acquisitions. The conventional 3-D partial CRS method is improved in this work and we call it as a wave-front-attribute-based 5-D interpolation (5-D WABI) as the two problems mentioned above are addressed. Data examples demonstrate the improved performance by the 5-D WABI method when compared with the conventional 3-D partial CRS approach. A comparison of the rank-reduction-based 5-D seismic interpolation technique with the proposed 5-D WABI method is given. The comparison reveals that

  15. Mapping onto Eq-5 D for patients in poor health

    Directory of Open Access Journals (Sweden)

    Brazier John E

    2010-11-01

    Full Text Available Abstract Background An increasing amount of studies report mapping algorithms which predict EQ-5 D utility values using disease specific non-preference-based measures. Yet many mapping algorithms have been found to systematically overpredict EQ-5 D utility values for patients in poor health. Currently there are no guidelines on how to deal with this problem. This paper is concerned with the question of why overestimation of EQ-5 D utility values occurs for patients in poor health, and explores possible solutions. Method Three existing datasets are used to estimate mapping algorithms and assess existing mapping algorithms from the literature mapping the cancer-specific EORTC-QLQ C-30 and the arthritis-specific Health Assessment Questionnaire (HAQ onto the EQ-5 D. Separate mapping algorithms are estimated for poor health states. Poor health states are defined using a cut-off point for QLQ-C30 and HAQ, which is determined using association with EQ-5 D values. Results All mapping algorithms suffer from overprediction of utility values for patients in poor health. The large decrement of reporting 'extreme problems' in the EQ-5 D tariff, few observations with the most severe level in any EQ-5 D dimension and many observations at the least severe level in any EQ-5 D dimension led to a bimodal distribution of EQ-5 D index values, which is related to the overprediction of utility values for patients in poor health. Separate algorithms are here proposed to predict utility values for patients in poor health, where these are selected using cut-off points for HAQ-DI (> 2.0 and QLQ C-30 ( Conclusion Mapping algorithms overpredict utility values for patients in poor health but are used in cost-effectiveness analyses nonetheless. Guidelines can be developed on when the use of a mapping algorithms is inappropriate, for instance through the identification of cut-off points. Cut-off points on a disease specific questionnaire can be identified through association

  16. On the 5d instanton index as a Hilbert series

    Energy Technology Data Exchange (ETDEWEB)

    Rodríguez-Gómez, Diego, E-mail: d.rodriguez.gomez@uniovi.es [Department of Physics, Universidad de Oviedo, Avda. Calvo Sotelo 18, 33007 Oviedo (Spain); Zafrir, Gabi, E-mail: gabizaf@techunix.technion.ac.il [Department of Physics, Technion, Israel Institute of Technology, Haifa 32000 (Israel)

    2014-01-15

    The superconformal index for N=2 5d theories contains a non-perturbative part arising from 5d instantonic operators which coincides with the Nekrasov instanton partition function. In this article, for pure gauge theories, we elaborate on the relation between such instanton index and the Hilbert series of the instanton moduli space. We propose a non-trivial identification of fugacities allowing the computation of the instanton index through the Hilbert series. We show the agreement of our proposal with existing results in the literature, as well as use it to compute the exact index for a pure U(1) gauge theory.

  17. 5D Building Information Modelling – A Practicability Review

    Directory of Open Access Journals (Sweden)

    Lee Xia Sheng

    2016-01-01

    Full Text Available Quality, time and cost are the three most important elements in any construction project. Building information that comes timely and accurately in multiple dimensions will facilitate a refined decision making process which can improve the construction quality, time and cost. 5 dimensional Building Information Modelling or 5D BIM is an emerging trend in the construction industry that integrates all the major information starting from the initial design to the final construction stage. After that, the integrated information is arranged and communicated through Virtual Design and Construction (VDC. This research is to gauge the practicability of 5D BIM with an action research type pilot study by the means of hands-on modelling of a conceptual bungalow design based on one of the most popular BIM tools. A bungalow is selected as a study subject to simulate the major stages of 5D BIM digital workflow. The whole process starts with developing drawings (2D into digital model (3D, and is followed by the incorporation of time (4D and cost (5D. Observations are focused on the major factors that will affect the practicability of 5D BIM, including the modelling effort, inter-operability, information output and limitations. This research concludes that 5D BIM certainly has high level practicability which further differentiates BIM from Computer Aided Design (CAD. The integration of information not only enhanced the efficiency and accuracy of process in all stages, but also enabled decision makers to have a sophisticated interpretation of information which is almost impossible with the conventional 2D CAD workflow. Although it is possible to incorporate more than 5 dimensions of information, it is foreseeable that excessive information may escalate the complexity unfavourably for BIM implementation. 5D BIM has achieved a significant level of practicability; further research should be conducted to streamline implementation. Once 5D BIM is matured and widely

  18. Suppressing Electroweak Precision Observables in 5D Warped Models

    CERN Document Server

    Cabrer, Joan A; Quiros, Mariano

    2011-01-01

    We elaborate on a recently proposed mechanism to suppress large contributions to the electroweak precision observables in five dimensional (5D) warped models, without the need for an extended 5D gauge sector. The main ingredient is a modification of the AdS metric in the vicinity of the infrared (IR) brane corresponding to a strong deviation from conformality in the IR of the 4D holographic dual. We compute the general low energy effective theory of the 5D warped Standard Model, emphasizing additional IR contributions to the wave function renormalization of the light Higgs mode. We also derive expressions for the S and T parameters as a function of a generic 5D metric and zero-mode wave functions. We give an approximate formula for the mass of the radion that works even for strong deviation from the AdS background. We proceed to work out the details of an explicit model and derive bounds for the first KK masses of the various bulk fields. The radion is the lightest new particle although its mass is already at...

  19. Predicting productivity based on EQ-5D: an explorative study.

    Science.gov (United States)

    Krol, Marieke; Stolk, Elly; Brouwer, Werner

    2014-06-01

    Productivity costs are often ignored in economic evaluations. In order to facilitate productivity cost inclusion, it has been suggested to estimate productivity costs indirectly using quality of life data. This study aimed to derive and validate an algorithm for predicting productivity losses on the basis of quality-of-life data using the EQ-5D-3L. A large representative sample of the Dutch general public (n = 1,100) was asked in a web-based questionnaire to state their expected level of productivity in terms of absenteeism and presenteeism for multiple EQ-5D health states. Based on these data, two generalized estimating equations (GEE) models were constructed: (1) a model predicting levels of absenteeism and (2) a model predicting presenteeism. The models were validated by comparing model predictions with conventionally measured productivity within a group of low back pain patients. Predicted absenteeism levels based on EQ-5D health state closely resembled conventionally measured absenteeism levels. Productivity losses related to presenteeism seemed somewhat overestimated by our prediction model. Measured and predicted productivity were moderately but highly significantly correlated. Overall, it appears possible to make reasonable productivity predictions based on EQ-5D data. Further exploration and validation of prediction algorithms remains necessary, however, especially for presenteeism.

  20. EQ-5D Utilities in Chronic Spontaneous/Idiopathic Urticaria.

    Science.gov (United States)

    Hawe, Emma; McBride, Doreen; Balp, Maria-Magdalena; Tian, Haijun; Halliday, Anna; Stull, Donald E

    2016-05-01

    To obtain utility estimates suitable for use in economic models for chronic spontaneous (idiopathic) urticaria (CSU). Patient-level data from three randomized clinical trials-ASTERIA I, ASTERIA II and GLACIAL-were analysed. Health states were derived from the Urticaria Activity Score over 7 days (UAS7); higher scores denote greater activity. The health state score ranges were urticaria free: 0; well-controlled urticaria: 1-6; mild urticaria: 7-15; moderate urticaria: 16-27; and severe urticaria: 28-42. The mean EQ-5D utilities were calculated for each health state. A mixed model was used to predict the EQ-5D according to UAS7 health states in a pooled data set containing all treatment arms and time points from the three trials. Pooled trial data were validated through visual comparisons and interaction terms. Fixed and random effects for trials and patients were included, along with the following covariates: UAS7 health state at baseline (moderate or severe); presence of angioedema at baseline and during follow-up; duration of CSU; number of previous CSU medications; visit; current treatment; and patient age and sex. There was a consistent improvement in EQ-5D utilities as urticaria activity decreased. The mean utilities ranged from 0.710 (severe urticaria) to 0.780 (moderate urticaria), 0.829 (mild urticaria), 0.862 (well-controlled urticaria) and 0.894 (urticaria free). Sensitivity and subgroup analyses confirmed the robustness of the results. The results suggest that EQ-5D utility scores increase with decreasing urticaria activity. EQ-5D utility scores enable the health-related quality of life of CSU patients to be compared with that of patients with other diseases.

  1. Validity of EQ-5D-5L in stroke.

    Science.gov (United States)

    Golicki, Dominik; Niewada, Maciej; Buczek, Julia; Karlińska, Anna; Kobayashi, Adam; Janssen, M F; Pickard, A Simon

    2015-04-01

    To assess EQ-5D-5L (5L) validity in patients with acute stroke, in comparison with EQ-5D-3L (3L). Cross-sectional study of 408 patients during index hospitalization. We compared 5L and 3L in terms of feasibility, frequency of unique health states, ceiling effect and discriminatory power (informativity). We assessed construct validity in terms of known-groups validity and convergent validity of 5L dimensions with other stroke outcome measures. The overall proportion of patients with acute stroke reporting 'no problems' with 3L-6.1 % was further reduced to 5.6 % with 5L (relative reduction of 8.2 %). The highest improvement in relative discriminatory power, when moving from 3L to 5L, was noticed in pain/discomfort and anxiety/depression dimensions (Shannon Evenness Index 0.91 for both 5L dimensions; relative increase 34.4 and 29.1 %, respectively). Known-groups validity tests confirmed prior hypotheses: Health state utilities were lower in following subpopulations-females, patients with high modified Rankin Scale (mRS) score, low Barthel Index (BI) or VAS score, patients with subarachnoid hemorrhage or intracerebral hemorrhage, and when proxy respondent was used. Convergence of EQ-5D-5L dimensions with mRS, BI and EQ VAS was improved or at least the same as for 3L dimensions. Results support the validity of the EQ-5D-5L descriptive system as a generic health outcome measure in patients with acute stroke, demonstrating some psychometric advantages in comparison with EQ-5D-3L.

  2. Natural inflation from 5D SUGRA and low reheat temperature

    Directory of Open Access Journals (Sweden)

    Filipe Paccetti Correia

    2015-09-01

    Full Text Available Motivated by recent cosmological observations of a possibly unsuppressed primordial tensor component r of inflationary perturbations, we reanalyze in detail the 5D conformal SUGRA originated natural inflation model of Ref. [1]. The model is a supersymmetric variant of 5D extranatural inflation, also based on a shift symmetry, and leads to the potential of natural inflation. Coupling the bulk fields generating the inflaton potential via a gauge coupling to the inflaton with brane SM states we necessarily obtain a very slow gauge inflaton decay rate and a very low reheating temperature Tr≲O(100 GeV. Analysis of the required number of e-foldings (from the CMB observations leads to values of ns in the lower range of present Planck 2015 results. Some related theoretical issues of the construction, along with phenomenological and cosmological implications, are also discussed.

  3. Surface relaxation and stress for 5d transition metals

    Science.gov (United States)

    Zólyomi, V.; Vitos, L.; Kwon, S. K.; Kollár, J.

    2009-03-01

    Using the density functional theory, we present a systematic theoretical study of the layer relaxation and surface stress of 5d transition metals. Our calculations predict layer contractions for all surfaces, except for the (111) surface of face centered cubic Pt and Au, where slight expansions are obtained similarly to the case of the 4d series. We also find that the relaxations of the close packed surfaces decrease with increasing occupation number through the 5d series. The surface stress for the relaxed, most closely packed surfaces shows similar atomic number dependence as the surface energy. Using Cammarata's model and our calculated surface stress and surface energy values, we examine the possibility of surface reconstructions, which is in reasonable agreement with the experimental observations.

  4. Facade Reconstruction with Generalized 2.5d Grids

    Directory of Open Access Journals (Sweden)

    J. Demantke

    2013-10-01

    Full Text Available Reconstructing fine facade geometry from MMS lidar data remains a challenge: In addition to being inherently sparse, the point cloud provided by a single street point of view is necessarily incomplete. We propose a simple framework to estimate the facade surface with a deformable 2.5d grid. Computations are performed in a "sensor-oriented" coordinate system that maximizes consistency with the data. the algorithm allows to retrieve the facade geometry without priori knowledge. It can thus be automatically applied to a large amount of data in spite of the variability of encountered architectural forms. The 2.5d image structure of the output makes it compatible with storage and real-time constraints of immersive navigation.

  5. EOS 5D Mark III の開発

    National Research Council Canada - National Science Library

    前野, 浩

    2013-01-01

    デジタル一眼レフカメラEOS 5D Mark III は,35 mm フルサイズ・2230 万画素CMOS センサーを搭載し,視野率約100%ファインダー,61 点AF,常用ISO 感度100 ~25600,多重露出撮影,HDR...

  6. Resources.

    Science.gov (United States)

    Stewart, John; MacDonald, Ian

    1980-01-01

    Presents a guide to resources on television drama available to teachers for classroom use in television curriculum. Lists American and British television drama videorecordings of both series and individual presentations and offers a bibliography of "one-off" single fiction plays produced for British television. (JMF)

  7. A black hole with torsion in 5D Lovelock gravity

    Science.gov (United States)

    Cvetković, B.; Simić, D.

    2018-03-01

    We analyze static spherically symmetric solutions of five dimensional (5D) Lovelock gravity in the first order formulation. In the Riemannian sector, when torsion vanishes, the Boulware–Deser black hole represents a unique static spherically symmetric black hole solution for the generic choice of the Lagrangian parameters. We show that a special choice of the Lagrangian parameters, different from the Lovelock Chern–Simons gravity, leads to the existence of a static black hole solution with torsion, the metric of which is asymptotically anti-de Sitter (AdS). We calculate the conserved charges and thermodynamical quantities of this black hole solution.

  8. Nearly free electrons in a 5d delafossite oxide metal

    OpenAIRE

    Kushwaha, Pallavi; Sunko, Veronika; Moll, P. J. W.; Bawden, Lewis; Riley, Jonathon Mark; Nandi, Nabhanila; Rosner, H.; Schmidt, M. P.; F. Arnold; Hassinger, E.; Kim, T. K.; Hoesch, M.; MacKenzie, Andrew; KING, Phil

    2015-01-01

    Understanding the role of electron correlations in strong spin-orbit transition-metal oxides is key to the realization of numerous exotic phases including spin-orbit–assisted Mott insulators, correlated topological solids, and prospective new high-temperature superconductors. To date, most attention has been focused on the 5d iridium-based oxides. We instead consider the Pt-based delafossite oxide PtCoO2. Our transport measurements, performed on single-crystal samples etched to well-defined g...

  9. Duality and dimensional reduction of 5D BF theory

    Energy Technology Data Exchange (ETDEWEB)

    Amoretti, A.; Blasi, A.; Caruso, G.; Maggiore, N.; Magnoli, N. [Universita di Genova, Dipartimento di Fisica, Genova (Italy); INFN, Sezione di Genova, Genova (Italy)

    2013-06-15

    A planar boundary introduced a la Symanzik in the 5D topological BF theory, with only the requirements of locality and power counting, allows to uniquely determine a gauge invariant, non-topological 4D Lagrangian. The boundary condition on the bulk fields is interpreted as a duality relation for the boundary fields, in analogy with the fermionization duality which holds in the 3D case. This suggests that the 4D degrees of freedom might be fermionic, although starting from a bosonic bulk theory. The method we propose to dimensionally reduce a Quantum Field Theory and to identify the resulting degrees of freedom can be applied to a generic spacetime dimension. (orig.)

  10. Social valuation of EQ-5D health states: the Chilean case.

    Science.gov (United States)

    Zarate, Victor; Kind, Paul; Valenzuela, Paulina; Vignau, Alberto; Olivares-Tirado, Pedro; Munoz, Alberto

    2011-12-01

    Cost-effectiveness analysis has been recommended by many national agencies around the world as a valid methodology to improve resource allocation within the health-care system. If the preferences of the society are taken into account in such a decision-making process, it is generally recommended that these values should be elicited by using a generic health-related quality-of-life instrument, such as the EuroQol five-dimensional (EQ-5D) questionnaire. To estimate a set of social values for EQ-5D questionnaire based on the time trade-off valuation technique for use in Chile. A valuation questionnaire was applied to a probabilistic sample of 2000 individuals, aged 20 years or older, living in the Metropolitan region. The fieldwork took place during October to November 2008. Utility weights for 42 health states were calculated directly by the application of time trade-off. Several random effect and ordinary least-squares regression models were fitted to these valuations to predict the full set of 243 health states generated by the EQ-5D system. The best model was chosen by applying criteria of parsimony, goodness of fit, and prediction capacity. The selected regression model was robust and showed better predictive characteristics than others reported in similar studies conducted elsewhere. The chosen regression model showed a R(2) of 0.34, mean absolute error of 0.017, and high predictive capacity. This study provides an EQ-5D social value set for domestic use in Chile. Our results differ from those reported in other countries, justifying the need to perform local studies that adequately reflect societal health preferences. Copyright © 2011 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  11. Improving valuation sampling of EQ-5D health states

    Science.gov (United States)

    2013-01-01

    Background The original valuation exercise which formed the basis of the UK EQ-5D time trade-off social tariff of health states, employed a sampling scheme involving 43 health states. Neither that study, nor other published international valuations studies have used explicit quantifiable criteria to justify the choice of sampled states. New criteria are proposed and methods described to aid researchers in designing improved sampling schemes for future EQ-5D sampling exercises. Method Four such criteria are described, and applied to assess the merits of four sampling schemes previously reported, using three large observational databases to quantify relative performance. An alternative sampling design conforming to these criteria is described, which aims to generate improved performance. Results Previous published approaches are shown to perform poorly against the measured criteria. The alternative sampling design is demonstrated to provide superior performance on all measures. Conclusion Future valuation exercises using sampled health states based on this approach may be expected to offer benefits in terms of greater precision, avoidance of bias in favour of less severe states, and a higher proportion of research observations valued directly rather than dependent on extrapolation modelling. PMID:23369105

  12. Nearly free electrons in a 5d delafossite oxide metal.

    Science.gov (United States)

    Kushwaha, Pallavi; Sunko, Veronika; Moll, Philip J W; Bawden, Lewis; Riley, Jonathon M; Nandi, Nabhanila; Rosner, Helge; Schmidt, Marcus P; Arnold, Frank; Hassinger, Elena; Kim, Timur K; Hoesch, Moritz; Mackenzie, Andrew P; King, Phil D C

    2015-10-01

    Understanding the role of electron correlations in strong spin-orbit transition-metal oxides is key to the realization of numerous exotic phases including spin-orbit-assisted Mott insulators, correlated topological solids, and prospective new high-temperature superconductors. To date, most attention has been focused on the 5d iridium-based oxides. We instead consider the Pt-based delafossite oxide PtCoO2. Our transport measurements, performed on single-crystal samples etched to well-defined geometries using focused ion beam techniques, yield a room temperature resistivity of only 2.1 microhm·cm (μΩ-cm), establishing PtCoO2 as the most conductive oxide known. From angle-resolved photoemission and density functional theory, we show that the underlying Fermi surface is a single cylinder of nearly hexagonal cross-section, with very weak dispersion along k z . Despite being predominantly composed of d-orbital character, the conduction band is remarkably steep, with an average effective mass of only 1.14m e. Moreover, the sharp spectral features observed in photoemission remain well defined with little additional broadening for more than 500 meV below E F, pointing to suppressed electron-electron scattering. Together, our findings establish PtCoO2 as a model nearly-free-electron system in a 5d delafossite transition-metal oxide.

  13. Does the EQ-5D reflect lost earnings?

    Science.gov (United States)

    Tilling, Carl; Krol, Marieke; Tsuchiya, Aki; Brazier, John; Exel, Job van; Brouwer, Werner

    2012-01-01

    An important methodological issue in economic evaluations of healthcare is how to include productivity costs (the costs related to reduced productivity due to illness, disability and premature death). Traditionally, they were included in the numerator of a cost-effectiveness analysis, through either the human-capital or the friction-cost method. It has been argued, however, that productivity costs are already included in the denominator (i.e. in the QALY measure) because respondents consider the effect a given health state will have on their income when valuing health states. If that is the case, many previous economic evaluations might have double counted productivity costs by including them in both the numerator and the denominator. The aim of this study was to determine whether respondents valuing EQ-5D health states using the time trade-off (TTO) method spontaneously consider income effects, whether this consideration influences subsequent valuations and whether explicit ex post instructions influence valuations. Through an online survey, we asked 321 members of the Dutch general population to value four EQ-5D health states through three different TTO exercises. The first exercise was a standard TTO question. Respondents were then asked whether they had included income effects. Depending on their answer, the second TTO exercise instructed them to either include or exclude income effects. The third TTO exercise provided explicit information regarding the income loss associated with the health state. Data were available from 321 members of the Dutch general public. Of these respondents, 49% stated they had spontaneously included income effects. Twenty-five percent of the sample did not trade any time in any of the TTO exercises and these respondents were excluded from the analysis. Results of t-tests showed there were only weakly significant differences in valuations for one health state between those who spontaneously included income effects and those who did

  14. Brazilian Valuation of EQ-5D-3L Health States: Results from a Saturation Study.

    Science.gov (United States)

    Santos, Marisa; Cintra, Monica A C T; Monteiro, Andrea L; Santos, Braulio; Gusmão-Filho, Fernando; Andrade, Mônica Viegas; Noronha, Kenya; Cruz, Luciane N; Camey, Suzi; Tura, Bernardo; Kind, Paul

    2016-02-01

    Most EQ-5D-3L valuation studies include the same sample of health states that was used in the protocol of the original UK Measurement and Valuation of Health (MVH) study. Thus far, no studies using a time tradeoff utility elicitation method have been carried out using all 243 EQ-5D health states. Because the values and preferences regarding health outcomes differ among countries, it is essential to have country-specific data to enable local high-level decisions regarding resource allocation. This study developed a country-specific set of values for EQ-5D-3L health states. A multicentric study was conducted in 4 Brazilian areas. A probabilistic sample of the general population, aged 18 to 64 y, stratified by age and gender, was surveyed. The interview followed a revised version of the MVH protocol, in which all 243 health states were valued. Each respondent ranked and valued 7 health states using the TTO in a home interview. Data were collected from 9148 subjects. The best-fitting regression model was an individual-level mixed-effects model without any interaction terms. The dimensions "Mobility" and "Usual Activities" were associated with higher losses in health state utility value. The "Anxiety/Depression" dimension was the domain that contributed to lower losses in health state utility value. This study generated significant insight into the Brazilian population's health preferences that can be applied to health technology assessment and economic analyses in Brazil. This information represents an important new tool that can be used in Brazilian health policy creation and evaluation. © The Author(s) 2015.

  15. Nematode Indicators of Organic Enrichment

    NARCIS (Netherlands)

    Ferris, H.; Bongers, A.M.T.

    2006-01-01

    The organisms of the soil food web, dependent on resources from plants or on amendment from other sources, respond characteristically to enrichment of their environment by organic matter. Primary consumers of the incoming substrate, including bacteria, fungi, plant-feeding nematodes, annelids, and

  16. Clinimetric properties of the EuroQol-5D in patients with chronic low back pain

    NARCIS (Netherlands)

    Soer, R.; Reneman, M.F.; Speijer, B.L.; Coppes, M.H.; Vroomen, P.C.

    2012-01-01

    BACKGROUND CONTEXT: Clinimetric properties of the EuroQol-5D (EQ-5D) in patients with nonspecific chronic low back pain (CLBP) are largely unknown. PURPOSE: To study the criterion validity, responsiveness, and minimal clinically important change (MCIC) of EQ-5D in patients with CLBP. STUDY DESIGN:

  17. Genetics Home Reference: PPP2R5D-related intellectual disability

    Science.gov (United States)

    ... Health Conditions PPP2R5D-related intellectual disability PPP2R5D-related intellectual disability Printable PDF Open All Close All Enable Javascript ... view the expand/collapse boxes. Description PPP2R5D -related intellectual disability is a neurological disorder characterized by moderate to ...

  18. Japanese population norms for preference-based measures: EQ-5D-3L, EQ-5D-5L, and SF-6D.

    Science.gov (United States)

    Shiroiwa, Takeru; Fukuda, Takashi; Ikeda, Shunya; Igarashi, Ataru; Noto, Shinichi; Saito, Shinya; Shimozuma, Kojiro

    2016-03-01

    The purpose of this study was to measure the population norms for the Japanese versions of preference-based measures (EQ-5D-3L, EQ-5D-5L, and SF-6D). We also considered the relations between QOL score in the general population and socio-demographic factors. A total of 1143 adult respondents (aged ≥ 20 years) were randomly sampled from across Japan using data from the Basic Resident Register. The health status of each respondent was measured using the EQ-5D-3L, EQ-5D-5L, and SF-6D, and responses regarding socio-demographic data as well as subjective diseases and symptoms were obtained. The responses were converted to a QOL score using Japanese value sets. The percentages of respondents with full health scores were 68 % (EQ-5D-3L), 55 % (EQ-5D-5L), and 4 % (SF-6D). The QOL score measured using the SF-6D was significantly lower than those measured using either EQ-5D score. The QOL score was significantly lower among respondents over the age of 60 years, those who had a lower income, and those who had a shorter period of education. Intraclass correlation coefficient showed a poor agreement between the EQ-5D and SF-6D scores. The differences in QOL scores between respondents with and those without any disease were 0.064 for the EQ-5D-3L, 0.061 for the EQ-5D-5L, and 0.073 for the SF-6D; these differences are regarded as between-group minimal important differences in the general population. The Japanese population norms of three preference-based QOL measures were examined for the first time. Such information is useful for economic evaluations and research examining QOL score.

  19. Expression of the innate defense receptor S5D-SRCRB in the urogenital tract

    DEFF Research Database (Denmark)

    Miro-Julia, C.; Escoda-Ferran, C.; Carrasco, E.

    2014-01-01

    S5D-SRCRB is a novel mouse secretory glycoprotein belonging to the ancient and highly conserved scavenger receptor cysteine-rich superfamily of protein receptors. Available evidence indicates that S5D-SRCRB interacts with conserved microbial cell wall components, as well as with some endogenous...... proteins, and presents a restricted tissue expression pattern. This study further analyzes the expression of S5D-SRCRB along the mouse urogenital tract. Immunohistochemical staining for S5D-SRCRB was observed in spermatocytes from seminiferous tubules and in the epithelial surface from urethra and bladder......, as well as in kidney tubules, mainly from medulla and papilla. Double stainings showed that S5D-SRCRB is expressed in both principal (P) and intercalated (IC) cells from renal collecting ducts (CD). By using an in vitro cell model of IC cell differentiation, preferential expression of S5D...

  20. 5-brane webs, symmetry enhancement, and duality in 5d supersymmetric gauge theory

    Energy Technology Data Exchange (ETDEWEB)

    Bergman, Oren [Department of Physics, Technion, Israel Institute of Technology,Haifa, 32000 (Israel); Rodríguez-Gómez, Diego [Department of Physics, Universidad de Oviedo,Avda. Calvo Sotelo 18, 33007, Oviedo (Spain); Zafrir, Gabi [Department of Physics, Technion, Israel Institute of Technology,Haifa, 32000 (Israel)

    2014-03-25

    We present a number of investigations of 5d N=1 supersymmetric gauge theories that make use of 5-brane web constructions and the 5d superconformal index. These include an observation of enhanced global symmetry in the 5d fixed point theory corresponding to SU(N) gauge theory with Chern-Simons level ±N, enhanced global symmetries in quiver theories, and dualities between quiver theories and non-quiver theories. Instanton contributions play a crucial role throughout.

  1. 2.5 D Simulation of basin-edge effects on the ground motion ...

    Indian Academy of Sciences (India)

    Abstract. The effects of basin-edge and soil velocity on the ground motion characteristics have been simulated using 2.5D modeling. One of the most significant advantages of the 2.5D simulation is that 3D radiation pattern can be generated in a 2D numerical grid using double-couple shear dislocation source. Further, 2.5D ...

  2. The EQ-5D: A useful quality of life measure in borderline personality disorder?

    Science.gov (United States)

    van Asselt, A D I; Dirksen, C D; Arntz, A; Giesen-Bloo, J H; Severens, J L

    2009-03-01

    Borderline Personality Disorder (BPD) is a severe psychiatric disorder and is associated with significant impairment in quality of life. The aim of the present study is to assess the internal and external responsiveness of the EuroQoL-5D (EQ-5D) in BPD patients. Data from 49 patients included in a multi-center Dutch randomized trial were used. We used both the EQ-5D utility score and the Visual Analogue Scale of the EuroQoL, and the Borderline Personality Disorder Severity Index-IV (BPDSI-IV). To determine internal responsiveness, we calculated the standardized response mean (SRM). To determine external responsiveness, we calculated Spearman correlations for the change scores, and compared EQ-5D scores for clinically improved vs. non-clinically improved patients as measured with the BPDSI-IV. Patient scores improved on all instruments during the three years. SRMs for BPDSI-IV were significantly higher than EQ-5D utility. Three-year Spearman correlation between change scores of BPDSI-IV and EQ-5D utility was 0.487, between BPDSI-IV and EQ-VAS it was 0.404, both statistically significant. EQ-5D utility scores for patients who clinically improved were significantly higher than for patients who did not. We conclude that the EQ-5D is fairly responsive in BPD, and, therefore, especially because of its brevity and user-friendliness, can serve as a useful tool in economic evaluations in patients with BPD.

  3. The EQ-5D : A useful quality of life measure in borderline personality disorder?

    NARCIS (Netherlands)

    van Asselt, A D I; Dirksen, C D; Arntz, A; Giesen-Bloo, J H; Severens, J L

    INTRODUCTION: Borderline Personality Disorder (BPD) is a severe psychiatric disorder and is associated with significant impairment in quality of life. The aim of the present study is to assess the internal and external responsiveness of the EuroQoL-5D (EQ-5D) in BPD patients. PATIENTS AND METHODS:

  4. EQ-5D health utilities: exploring ways to improve upon responsiveness in psoriasis.

    Science.gov (United States)

    Pickard, A Simon; Gooderham, Melinda; Hartz, Susanne; Nicolay, Claudia

    2017-01-01

    To determine if EuroQoL 5-Dimension Health Questionnaire (EQ-5D) health utility scores were able to discriminate among different levels of improvement in psoriasis severity following therapy. Data were from three placebo-controlled phase 3 ixekizumab studies (UNCOVER-1, UNCOVER-2, and UNCOVER-3) with patients who had baseline Dermatology Life Quality Index scores >10 (DLQI >10). Psoriasis severity (Psoriasis Area and Severity Index [PASI]), general health utility (EQ-5D), and psoriasis-specific utility (EQ-PSO, UNCOVER-3 only) were assessed. EQ-5D-5L utility scores were generated using the England EQ-5D-5L value set, a crosswalk applied to the EQ-5D-3L United States (US) and United Kingdom (UK) value sets, and a regression-based exploratory scoring function for the EQ-PSO (UK). Analysis of variance was used to estimate change in EQ-5D-5L from baseline to Week 12 per PASI improvement level: PASI 10 and available utility scores. At Week 12, mean EQ-5D utility scores increased with increasing PASI improvement levels (p psoriasis patients at the highest PASI improvement levels. ConclusionsL Adding psoriasis-specific EQ-PSO dimensions to the EQ-5D may enhance responsiveness to improvement in skin clarity at the highest PASI levels, and, therefore, generate utility scores that better reflect treatment benefit in cost-utility models.

  5. Comparison of hypothetical and experienced EQ-5D valuations: relative weights of the five dimensions

    DEFF Research Database (Denmark)

    Rand-Hendriksen, K.; Augestad, L. A.; Sønbø Kristiansen, Ivar

    2012-01-01

    -specific regression coefficients. We examined differences in the relative importance attributed to the EQ-5D dimensions between EH and HH valuations of EQ-5D states in the United States. Methods We used the regression model from the US EQ-5D valuation study on EH ratings from the 2000-2003 Medical Expenditure Panel...... Survey and on HH ratings from the US EQ-5D valuation study conducted in 2001. We then compared patterns in the relative magnitudes of coefficients that corresponded to the five dimensions. Results In the HH model, self-care and pain/discomfort were the most important dimensions, while usual activities......Purpose EQ-5D tariffs are typically based on general population valuations studies, but whether valuations of experienced health (EH) or hypothetical health (HH) are more appropriate is disputed. Previous comparisons of valuations of EH and HH have focused on absolute differences in dimension...

  6. The effect of environmental enrichment on the behavior of captive tufted capuchin monkeys (Cebus apella)

    DEFF Research Database (Denmark)

    Jacobsen, Kirsten R; Mikkelsen, L F; Hau, J

    2010-01-01

    The authors provided different forms of environmental enrichment to six old laboratory male tufted capuchin monkeys (Cebus apella) and studied the behavior of the monkeys during a baseline period and during three enrichment periods. Each observation period lasted 5 d, with an interval of 6 d betw...

  7. Bilateral implantation of +2.5 D multifocal intraocular lens and contralateral implantation of +2.5 D and +3.0 D multifocal intraocular lenses: Clinical outcomes

    NARCIS (Netherlands)

    Nuijts, Rudy M. M. A.; Jonker, Soraya M. R.; Kaufer, Robert A.; Lapid-Gortzak, Ruth; Mendicute, Javier; Martinez, Cristina Peris; Schmickler, Stefanie; Kohnen, Thomas

    2016-01-01

    To assess the clinical visual outcomes of bilateral implantation of Restor +2.5 diopter (D) multifocal intraocular lenses (IOLs) and contralateral implantation of a Restor +2.5 D multifocal IOL in the dominant eye and Restor +3.0 D multifocal IOL in the fellow eye. Multicenter study at 8

  8. Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus.

    Directory of Open Access Journals (Sweden)

    Su-li Wang

    Full Text Available OBJECTIVE: To investigate the construct and criterion validity of the Euro Qol-5D (EQ-5D, which allows quality-adjusted life-years to be calculated, in patients with systemic lupus erythematosus (SLE. METHODS: Consecutive SLE patients who had been followed at the Renji Hospital, School of Medicine, Shanghai Jiao Tong University were recruited. Cross-sectional correlations of the EQ-5D with equivalent domains in disease-specific health-related quality of life (HRQoL, LupusQol, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI measures, the Systemic Lupus International Collaborating Clinics Damage Index (SDI, and patient characteristics were tested. Discriminant validity to assess the ability to distinguish between patients of different disease severity was assessed. There also were evaluations of ceiling and floor effects. RESULTS: 240 patients were recruited in total. The EQ-5D correlated moderately to strongly with all domains of the LupusQoL (r: 0.44-0.7 apart from intimate relationships (r = 0.25 and body image (r = 0.18. There was moderate negative correlation between EQ-5D and clinical assessment of disease, SLEDAI (r = -0.589 and SDI (r = -0.509. When compared with equivalent domains on LupusQoL, there was good construct validity in EQ-5D (r: 0.631-0.812. EQ-5D could also discriminate patients with varied disease severity (according SLEDAI and SDI. There was no floor effect in EQ-5D but the ceiling effect remains strong (34%. CONCLUSION: Our results provide sufficient evidence that the EQ-5D displays construct and criterion validity for use in SLE patients. Disease-specific measures of HRQoL used alongside may be a better choice.

  9. Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus.

    Science.gov (United States)

    Wang, Su-li; Wu, Bin; Zhu, Li-an; Leng, Lin; Bucala, Richard; Lu, Liang-jing

    2014-01-01

    To investigate the construct and criterion validity of the Euro Qol-5D (EQ-5D), which allows quality-adjusted life-years to be calculated, in patients with systemic lupus erythematosus (SLE). Consecutive SLE patients who had been followed at the Renji Hospital, School of Medicine, Shanghai Jiao Tong University were recruited. Cross-sectional correlations of the EQ-5D with equivalent domains in disease-specific health-related quality of life (HRQoL), LupusQol, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) measures, the Systemic Lupus International Collaborating Clinics Damage Index (SDI), and patient characteristics were tested. Discriminant validity to assess the ability to distinguish between patients of different disease severity was assessed. There also were evaluations of ceiling and floor effects. 240 patients were recruited in total. The EQ-5D correlated moderately to strongly with all domains of the LupusQoL (r: 0.44-0.7) apart from intimate relationships (r = 0.25) and body image (r = 0.18). There was moderate negative correlation between EQ-5D and clinical assessment of disease, SLEDAI (r = -0.589) and SDI (r = -0.509). When compared with equivalent domains on LupusQoL, there was good construct validity in EQ-5D (r: 0.631-0.812). EQ-5D could also discriminate patients with varied disease severity (according SLEDAI and SDI). There was no floor effect in EQ-5D but the ceiling effect remains strong (34%). Our results provide sufficient evidence that the EQ-5D displays construct and criterion validity for use in SLE patients. Disease-specific measures of HRQoL used alongside may be a better choice.

  10. A review of health utilities using the EQ-5D in studies of cardiovascular disease

    Directory of Open Access Journals (Sweden)

    Goldsmith Kimberley A

    2010-01-01

    Full Text Available Abstract Background The EQ-5D has been extensively used to assess patient utility in trials of new treatments within the cardiovascular field. The aims of this study were to review evidence of the validity and reliability of the EQ-5D, and to summarise utility scores based on the use of the EQ-5D in clinical trials and in studies of patients with cardiovascular disease. Methods A structured literature search was conducted using keywords related to cardiovascular disease and EQ-5D. Original research studies of patients with cardiovascular disease that reported EQ-5D results and its measurement properties were included. Results Of 147 identified papers, 66 met the selection criteria, with 10 studies reporting evidence on validity or reliability and 60 reporting EQ-5D responses (VAS or self-classification. Mean EQ-5D index-based scores ranged from 0.24 (SD 0.39 to 0.90 (SD 0.16, while VAS scores ranged from 37 (SD 21 to 89 (no SD reported. Stratification of EQ-5D index scores by disease severity revealed that scores decreased from a mean of 0.78 (SD 0.18 to 0.51 (SD 0.21 for mild to severe disease in heart failure patients and from 0.80 (SD 0.05 to 0.45 (SD 0.22 for mild to severe disease in angina patients. Conclusions The published evidence generally supports the validity and reliability of the EQ-5D as an outcome measure within the cardiovascular area. This review provides utility estimates across a range of cardiovascular subgroups and treatments that may be useful for future modelling of utilities and QALYs in economic evaluations within the cardiovascular area.

  11. Collisional deactivation of Ba 5d7p (3)D1 by noble gases.

    Science.gov (United States)

    Smedley, John E; Coulter, Sarah K; Felton, Edward J; Zomlefer, Kayla S

    2008-10-02

    Collisional deactivation of the 5d7p (3)D1 state of Ba by noble gases is studied by time- and wavelength-resolved fluorescence techniques. A pulsed, frequency-doubled dye laser at 273.9 nm excites the 5d7p (3)D1 level from the ground state, and fluorescence at 364.1 and 366.6 nm from the 5d7p (3)D1 --> 6s5d (3)D1 and 5d7p (3)D1 --> 6s5d (3)D2 transitions, respectively, is monitored in real time to obtain the deactivation rate constants. At 835 K these rate constants are as follows: He, (1.69 +/- 0.08) x 10(-9) cm(3) s(-1); Ne, (3.93 +/- 0.14) x 10(-10) cm(3) s(-1); Ar, (4.53 +/- 0.15) x 10(-10) cm(3) s(-1); Kr, (4.64 +/- 0.13) x 10(-10) cm(3) s(-1); Xe, (5.59 +/- 0.22) x 10(-10) cm(3) s(-1). From time-resolved 5d7p (3)D1 emission in the absence of noble gas and from the intercepts of the quenching plots, the lifetime of this state is determined to be 100 +/- 1 ns. Using time- and wavelength-resolved Ba emission with a low background pressure of noble gas, radiative lifetimes of several near-resonant states are determined from the exponential rise of the fluorescence signals. These results are as follows: 5d6d (3)D3, 28 +/- 3 ns; 5d7p (3)P1, 46 +/- 2 ns; 5d6d (3)G3, 21.5 +/- 0.8 ns; 5d7p (3)F3, 48 +/- 1 ns. Integrated fluorescence signals are used to infer the relative rate constants for population transfer from the 5d7p (3)D1 state to eleven near-resonant fine structure states.

  12. Validity and reliability of EQ-5D-3L for breast cancer patients in Korea.

    Science.gov (United States)

    Kim, Seon-Ha; Jo, Min-Woo; Lee, Jong-Won; Lee, Hyeon-Jeong; Kim, Jong Kyung

    2015-12-23

    Recently, breast cancer incidence and prevalence has been increasing. Patients' health related quality of life is important considerations in the treatment of breast cancer. The EQ-5D-3L is one of most popular instruments to measure health related quality of life. This study was aimed to evaluate the validity and reliability of EQ-5D-3L in post-operative breast cancer patients from Korea. A total of 827 patients visiting the ambulatory cancer center of 1 tertiary hospital after breast cancer surgery self-administered the EQ-5D-3L and Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B). We evaluated known-group validity using differences in the EQ-5D-3L index and EQ-VAS score according to demographic and clinical data. The discriminatory ability of the EQ-5D-3L was determined by comparing the mean FACT-B subscale scores between subjects with no problems and subjects with moderate or severe problems in each EQ-5D-3L dimension. Construct validity was evaluated by Pearson correlation coefficients among the EQ-5D-3L index and FACT-B subscales, respectively. Reliability was assessed in terms of test-retest reliability using Cohen's kappa value and intra-class correlation coefficient (ICC). The EQ-5D-3L index and EQ-VAS score were higher in the educated, current radiotherapy and unmarried groups. The correlation of EQ-5D-3L index and subscales for the FACT-B was highest in physical well-being (r = 0.553) and lowest in social well-being (r = 0.199). For reliability, the Kappa values' range was from 0.32 to 0.70, and ICCs of the EQ-5D-3L index and EQ-VAS scores were 0.70 and 0.48, respectively. This study indicated that the EQ-5D-3L could be a valid health related quality of life instrument for postoperative breast cancer patients.

  13. [Contribution for the validation of the Portuguese version of EQ-5D].

    Science.gov (United States)

    Ferreira, Pedro Lopes; Ferreira, Lara Noronha; Pereira, Luis Nobre

    2013-01-01

    The EQ-5D allows the achievement of two essential components of any measure of health-related quality of life to be used in cost-utility economic evaluations: (i) a profile describing the health status in terms of domains or dimensions; and (ii) a numeric value associated with the health status described. The Portuguese version of the EQ-5D questionnaire was completed in 1998, based on guidelines set by the EuroQol Group, including translation and back translation procedures. Despite its wide use in Portugal, until now it had not yet been published studies that initially led to the Portuguese version and the guarantee of acceptability, reliability and validity. The purpose of this article is to document these first values relating to the Portuguese version of the EQ-5D. We used three different samples: a first one with 1,500 individuals representative of the Portuguese population; a second with 140 individuals just intended for the reliability test; and a third sample with 643 individual patients with cataracts, asthma, chronic obstructive pulmonary disease, or rheumatoid arthritis. The acceptability was assessed by the number of missing responses. It was also found a marked ceiling effect, with a large part of the sample not reporting any problems in the dimensions of the EQ-5D. The construct validity was tested by examining the degree to which low values of EQ-5D were positively associated with increasing age, being female, and the sick, as well as the values of dimensions of the SF-36v2 scale. Convergent validity was based on correlations between EQ-5D values and other specific measures. The EQ-5D showed moderate to high correlations with other disease-specific measures of health status and health related quality of life. We can state that the Portuguese version of the EQ-5D has a good accessibility, reliability and validity in measuring health.

  14. The 5D to 4D projection model applied as a Lepton to Galaxy Creation model

    CERN Document Server

    Wong, Kai-Wai; Jungner, Högne

    2013-01-01

    The 5D to 4D projection is presented in a simple geometry giving the Perelman Theorem, resulting in a 3D doughnut structure for the space manifold of the Lorentz space-time. It is shown that in the lowest quantum state, this Lorentz manifold confines and gives the de Broglie leptons from the massless 5D e-trinos. On the scale of the universe, it allows for a model for the creation of galaxies.

  15. Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups

    DEFF Research Database (Denmark)

    Janssen, M F; Pickard, A Simon; Golicki, Dominik

    2012-01-01

    PURPOSE: The aim of this study was to assess the measurement properties of the 5-level classification system of the EQ-5D (5L), in comparison with the 3-level EQ-5D (3L). METHODS: Participants (n = 3,919) from six countries, including eight patient groups with chronic conditions (cardiovascular......), redistribution properties, ceiling, discriminatory power, convergent validity, and known-groups validity. RESULTS: Missing values were on average 0.8 % for 5L and 1.3 % for 3L. In total, 2.9 % of responses were inconsistent between 5L and 3L. Redistribution from 3L to 5L using EQ dimension-specific rating scales...... of the 3-level system which improves upon the measurement properties, reducing the ceiling while improving discriminatory power and establishing convergent and known-groups validity....

  16. 4D superfield reduction of 5-D orbifold SUGRA and heterotic M-theory

    CERN Document Server

    Paccetti Correia, F.; Tavartkiladze, Zurab; Correia, Filipe Paccetti; Schmidt, Michael G.; Tavartkiladze, Zurab

    2006-01-01

    We present a detailed study of the reduction to 4D of 5D supergravity compactified on the S^1/Z_2 orbifold. For this purpose we develop and employ a recently proposed N=1 conformal superfield description of the 5D supergravity couplings to abelian vector and hypermultiplets. In particular, we obtain a unique relation of the "radion" to chiral superfields as in global 5D SUSY and we can embed the universal hypermultiplet into this formalism. In our approach, it is transparent how the superconformal structure of the effective 4D actions is inherited from the one of the original 5D supergravity. We consider both ungauged and gauged 5D supergravities. This includes compactifications in unwarped geometries, generalizations of the supersymmetric Randall-Sundrum (RS) model as well as 5D heterotic M-theory. In the unwarped case, after obtaining the effective Kaehler potentials and superpotentials, we demonstrate that the tree-level 4D potentials have flat and/or tachyonic directions. One-loop corrections to the Kaehl...

  17. Feasibility, acceptability and construct validity of EQ-5D in systemic sclerosis.

    Science.gov (United States)

    Gualtierotti, Roberta; Ingegnoli, Francesca; Scalone, Luciana; Cortesi, Paolo; Bruschi, Eleonora; Gerosa, Maria; Meroni, Pier Luigi

    2017-01-19

    Systemic sclerosis is a chronic disabling disease that is often associated with severe physical and psychological impairment. Nonetheless, health-related quality of life (HRQoL) in patients with systemic sclerosis is often left behind in clinical practice and research. One of the reasons for this lack of evaluation is the current use of tools, such as the short form-36 (SF-36) questionnaire, that are complete but complicated to use in everyday routine. Other self-reported outcome measures such as the health assessment questionnaire (HAQ) are simple, but specifically designed for physical disability. Our aim was to evaluate the feasibility, acceptability and construct validity of EQ-5D, a simple and quick self-assessment tool, and to compare its performance with SF-36 and HAQ. We investigated 119 consecutive patients with systemic sclerosis (94% female; age: median 63 years, interquartile range 53-70 years) at three different rheumatology centres. Acceptability was evaluated from comments made by the patients and feasibility on the basis of the number of patients needing assistance or not answering questions (missing data). Construct validity was based on both convergent and divergent validity between conceptually similar and dissimilar domains, respectively, of the compared instruments. EQ-5D was well accepted by patients. The percentage of patients missing data in at least one EQ-5D domain was 2.5%. Spearman's correlation coefficients between similar dimensions of EQ-5D vs SF-36 and vs HAQ were moderate (≥0.30) to strong (≥0.50); in contrast, correlation coefficients between less comparable dimensions were weak. As expected, the EQ-5D anxiety/depression domain did not correlate with any of the HAQ domains. The EQ-5D visual analogue scale (VAS) concordance with SF-36 general health domain and HAQ total score was strong (≥0.50 for both). Median value for the EQ-5D index (interquartile range) was 0.81 (0.75-0.86). The EQ-5D index had correlation coefficients >0

  18. Application of EQ-5D-5L questionnaire in patients suffering from urinary incontinence.

    Science.gov (United States)

    Garcia-Gordillo, M A; Collado-Mateo, D; Olivares, P R; Adsuar, J C

    2016-09-01

    Urinary incontinence is associated with reduced quality of life and given the high prevalence of people with this condition, it could be useful to know the impact of having urinary incontinence on physical, psychological and social aspects. The Spanish value set of EQ-5D was used to assign single scores to the EQ-5D-5L health states. EQ-5D-5L is a health-related quality of life questionnaire, which allows assessing health status. The aim of this study was to provide normative values of EQ-5D-5L in a population sample with urinary incontinence. Cross-sectional study. A total of 965 people with urinary incontinence (297 men and 668 women) were included in this study. EQ-5D-5L index, VAS and health status are showed in the current study considering gender, age group, region, marital status, smoking status, net monthly incomes of household and educational level. Higher prevalence was observed in women (69.22%) compared with men (30.78%). Mean (SD) EQ-5D-5L utility index and VAS score were 0.58 (0.40) and 53.91 (22.16), respectively, for overall population. The 16.1% (155 people) reported perfect health status (11111). The utility equivalent to set values 55555 was not reported by anyone. This study provides normative values of EQ-5D-5L in a Spanish population sample with urinary incontinence. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  19. Telephone reliability of the Frenchay Activity Index and EQ-5D amongst older adults.

    Science.gov (United States)

    McPhail, Steven; Lane, Paul; Russell, Trevor; Brauer, Sandra G; Urry, Steven; Jasiewicz, Jan; Condie, Peter; Haines, Terry

    2009-05-29

    Older adults may find it problematic to attend hospital appointments due to the difficulty associated with travelling to, within and from a hospital facility for the purpose of a face-to-face assessment. This study aims to investigate equivalence between telephone and face-to-face administration for the Frenchay Activities Index (FAI) and the Euroqol-5D (EQ-5D) generic health-related quality of life instrument amongst an older adult population. Patients aged >65 (n = 53) who had been discharged to the community following an acute hospital admission underwent telephone administration of the FAI and EQ-5D instruments seven days prior to attending a hospital outpatient appointment where they completed a face-to-face administration of these instruments. Overall, 40 subjects' datasets were complete for both assessments and included in analysis. The FAI items had high levels of agreement between the two modes of administration (item kappa's ranged 0.73 to 1.00) as did the EQ-5D (item kappa's ranged 0.67-0.83). For the FAI, EQ-5D VAS and EQ-5D utility score, intraclass correlation coefficients were 0.94, 0.58 and 0.82 respectively with paired t-tests indicating no significant systematic difference (p = 0.100, p = 0.690 and p = 0.290 respectively). Telephone administration of the FAI and EQ-5D instruments provides comparable results to face-to-face administration amongst older adults deemed to have cognitive functioning intact at a basic level, indicating that this is a suitable alternate approach for collection of this information.

  20. Telephone reliability of the Frenchay Activity Index and EQ-5D amongst older adults

    Directory of Open Access Journals (Sweden)

    Urry Steven

    2009-05-01

    Full Text Available Abstract Background Older adults may find it problematic to attend hospital appointments due to the difficulty associated with travelling to, within and from a hospital facility for the purpose of a face-to-face assessment. This study aims to investigate equivalence between telephone and face-to-face administration for the Frenchay Activities Index (FAI and the Euroqol-5D (EQ-5D generic health-related quality of life instrument amongst an older adult population. Methods Patients aged >65 (n = 53 who had been discharged to the community following an acute hospital admission underwent telephone administration of the FAI and EQ-5D instruments seven days prior to attending a hospital outpatient appointment where they completed a face-to-face administration of these instruments. Results Overall, 40 subjects' datasets were complete for both assessments and included in analysis. The FAI items had high levels of agreement between the two modes of administration (item kappa's ranged 0.73 to 1.00 as did the EQ-5D (item kappa's ranged 0.67–0.83. For the FAI, EQ-5D VAS and EQ-5D utility score, intraclass correlation coefficients were 0.94, 0.58 and 0.82 respectively with paired t-tests indicating no significant systematic difference (p = 0.100, p = 0.690 and p = 0.290 respectively. Conclusion Telephone administration of the FAI and EQ-5D instruments provides comparable results to face-to-face administration amongst older adults deemed to have cognitive functioning intact at a basic level, indicating that this is a suitable alternate approach for collection of this information.

  1. The 5D Fully-Covariant Theory of Gravitation and Its Astrophysical Applications

    Directory of Open Access Journals (Sweden)

    Tianxi Zhang

    2014-12-01

    Full Text Available In this paper, we comprehensively review the five-dimensional (5D fully-covariant theory of gravitation developed by Zhang two decades ago and its recent applications in astrophysics and cosmology. This 5D gravity describes not only the fields, but also the matter and its motion in a 5D spacetime. The greatest advantage of this theory is that there does not exist any unknown parameter, so that we can apply it to explain astrophysical and cosmological issues by quantitatively comparing the results obtained from it with observations and to predict new effects that could not be derived from any other gravitational theories. First, the 5D covariant description of matter and its motion enabled Zhang to analytically derive the fifteenth component of the 5D energy-momentum tensor of matter ( T - 44 , which significantly distinguishes this 5D gravity from other 5D gravitational theories that usually assumed a T - 44 with an unknown parameter, called the scalar charge s, and, thus, to split the 5D covariant field equation into (4 + 1 splitting form as the gravitational, electromagnetic, and scalar field equations. The gravitational field equation turns into the 4D Einstein’s field equation of general relativity if the scalar field is equal to unity. Then, Zhang solved the field equations and obtained an exact static spherically-symmetric external solution of the gravitational, electromagnetic and scalar fields, in which all integral constants were completely determined with a perfect set of simple numbers and parameters that only depend on the mass and electric charge of the matter, by comparing with the obtained weak internal solution of the fields at a large radial distance. In the Einstein frame, the exact field solution obtained from the 5D fully-covariant theory of gravitation reduces to the Schwarzschild solution when the matter is electrically neutral and the fields are weak in strength. This guarantees that the four fundamental tests (light

  2. Assessing the construct validity of the Italian version of the EQ-5D: preliminary results from a cross-sectional study in North Italy

    Directory of Open Access Journals (Sweden)

    Pandolfi Pier

    2006-08-01

    Full Text Available Abstract Background Information on health related quality of life (HR-QOL can be integrated with other classical health status indicators and be used to assist policy makers in resource allocation decisions. For this reason instruments such as the SF-12 and EQ-5D have been widely proposed as assessment tools to monitor changes in HR-QOL in general populations and very recently in general practice settings as well Aim The primary goal of our study was to assess the construct validity of the Italian version of the EQ-5D in a general population of North Italy using socio-demographic factors and diagnostic sub-groups. Our secondary goal was to assess the concurrent validity of the EQ-5D and SF-12. Methods The SF-12, the EQ-5D plus an additional questionnaire on socio-demographic characteristics, clinical conditions and symptoms were completed by 1,622 adults, randomly selected from the Registry of the Health Authorities of the city of Bologna, Italy. The primary care physician of each subject was contacted to report on the subject's health status. Results Our findings indicate that the Italian version of the EQ-5D is well accepted by the general population (91% response rate, has good reliability (Cronbach's alpha 0.73, and shows evidence of construct validity. Conclusion Our data provide a basis for further research to be conducted to assess the validity of the EQ-5D in Italy. In particular future studies should focus on assessing its ability to detect a clinically important change in health related quality of life over time (responsiveness.

  3. Bilateral implantation of +2.5 D multifocal intraocular lens and contralateral implantation of +2.5 D and +3.0 D multifocal intraocular lenses: Clinical outcomes.

    Science.gov (United States)

    Nuijts, Rudy M M A; Jonker, Soraya M R; Kaufer, Robert A; Lapid-Gortzak, Ruth; Mendicute, Javier; Martinez, Cristina Peris; Schmickler, Stefanie; Kohnen, Thomas

    2016-02-01

    To assess the clinical visual outcomes of bilateral implantation of Restor +2.5 diopter (D) multifocal intraocular lenses (IOLs) and contralateral implantation of a Restor +2.5 D multifocal IOL in the dominant eye and Restor +3.0 D multifocal IOL in the fellow eye. Multicenter study at 8 investigative sites. Prospective randomized parallel-group patient-masked 2-arm study. This study comprised adults requiring bilateral cataract extraction followed by multifocal IOL implantation. The primary endpoint was corrected intermediate visual acuity (CIVA) at 60 cm, and the secondary endpoint was corrected near visual acuity (CNVA) at 40 cm. Both endpoints were measured 3 months after implantation with a noninferiority margin of Δ = 0.1 logMAR. In total, 103 patients completed the study (53 bilateral, 50 contralateral). At 3 months, the mean CIVA at 60 cm was 0.13 logMAR and 0.10 logMAR in the bilateral group and contralateral group, respectively (difference 0.04 logMAR), achieving noninferiority. Noninferiority was not attained for CNVA at 40 cm; mean values at 3 months for bilateral and contralateral implantation were 0.26 logMAR and 0.11 logMAR, respectively (difference 0.15 logMAR). Binocular defocus curves suggested similar performance in distance vision between the 2 groups. Treatment-emergent ocular adverse events rates were similar between the groups. Bilateral implantation of the +2.5 D multifocal IOL resulted in similar distance as contralateral implantation of the +2.5 D multifocal IOL and +3.0 D multifocal IOL for intermediate vision (60 cm), while noninferiority was not achieved for near distances (40 cm). Copyright © 2016 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  4. 2.5D Multi-View Gait Recognition Based on Point Cloud Registration

    Directory of Open Access Journals (Sweden)

    Jin Tang

    2014-03-01

    Full Text Available This paper presents a method for modeling a 2.5-dimensional (2.5D human body and extracting the gait features for identifying the human subject. To achieve view-invariant gait recognition, a multi-view synthesizing method based on point cloud registration (MVSM to generate multi-view training galleries is proposed. The concept of a density and curvature-based Color Gait Curvature Image is introduced to map 2.5D data onto a 2D space to enable data dimension reduction by discrete cosine transform and 2D principle component analysis. Gait recognition is achieved via a 2.5D view-invariant gait recognition method based on point cloud registration. Experimental results on the in-house database captured by a Microsoft Kinect camera show a significant performance gain when using MVSM.

  5. Does the EQ-5D measure quality of life in schizophrenia?

    DEFF Research Database (Denmark)

    Halling Hastrup, Lene; Nordentoft, Merete; Hjorthoej, Carsten

    2011-01-01

    a generic preference based outcome measure, like EQ-5D, in health economic evaluations in order to allow for comparisons of health related quality of life of patient groups across different diseases, providing information particular useful to support health policy decisions and cost-effectiveness analysis......Most health economic evaluations in mental care include outcome measures aimed at specific aspects of health, like symptom improvement, functional improvement and quality of life instead of generic preference based outcome measures. The health economic guidelines (NICE) recommend to include....... Although the EQ-5D is by far the most widespread outcome measure within the context of economic evaluations, its validity in psychiatric populations has not yet been established unambiguously. An increasing number of articles have tested the validity of the EQ-5D in comparisons with clinical measures...

  6. 2.5D multi-view gait recognition based on point cloud registration.

    Science.gov (United States)

    Tang, Jin; Luo, Jian; Tjahjadi, Tardi; Gao, Yan

    2014-03-28

    This paper presents a method for modeling a 2.5-dimensional (2.5D) human body and extracting the gait features for identifying the human subject. To achieve view-invariant gait recognition, a multi-view synthesizing method based on point cloud registration (MVSM) to generate multi-view training galleries is proposed. The concept of a density and curvature-based Color Gait Curvature Image is introduced to map 2.5D data onto a 2D space to enable data dimension reduction by discrete cosine transform and 2D principle component analysis. Gait recognition is achieved via a 2.5D view-invariant gait recognition method based on point cloud registration. Experimental results on the in-house database captured by a Microsoft Kinect camera show a significant performance gain when using MVSM.

  7. Hund’s Rule-Driven Dzyaloshinskii-Moriya Interaction at 3d−5d Interfaces

    KAUST Repository

    Belabbes, Abderrezak

    2016-12-09

    Using relativistic first-principles calculations, we show that the chemical trend of the Dzyaloshinskii-Moriya interaction (DMI) in 3d-5d ultrathin films follows Hund\\'s first rule with a tendency similar to their magnetic moments in either the unsupported 3d monolayers or 3d-5d interfaces. We demonstrate that, besides the spin-orbit coupling (SOC) effect in inversion asymmetric noncollinear magnetic systems, the driving force is the 3d orbital occupations and their spin-flip mixing processes with the spin-orbit active 5d states control directly the sign and magnitude of the DMI. The magnetic chirality changes are discussed in the light of the interplay between SOC, Hund\\'s first rule, and the crystal-field splitting of d orbitals. © 2016 American Physical Society.

  8. Comparing EQ-5D valuation studies: a systematic review and methodological reporting checklist.

    Science.gov (United States)

    Xie, Feng; Gaebel, Kathryn; Perampaladas, Kuhan; Doble, Brett; Pullenayegum, Eleanor

    2014-01-01

    There has been a growing interest around the world in developing country-specific scoring algorithms for the EQ-5D. This study systematically reviews all existing EQ-5D valuation studies to highlight their strengths and limitations, explores heterogeneity in observed utilities using meta-regression, and proposes a methodological checklist for reporting EQ-5D valuation studies. . We searched Medline, EMBASE, the National Health Service Economic Evaluation Database (NHS EED) via Wiley's Cochrane Library, and Wiley's Health Economic Evaluation Database from inception through November 2012, as well as bibliographies of key papers and the EuroQol Plenary Meeting Proceedings from 1991 to 2012 for English-language reports of EQ-5D valuation studies. Two reviewers independently screened the titles and abstracts for relevance. Three reviewers performed data extraction and compared the characteristics and scoring algorithms developed in the included valuation studies. . Of the 31 studies included in the review, 19 used the time trade-off (TTO) technique, 10 used the visual analogue scale (VAS) technique, and 2 used both TTO and VAS. Most studies included respondents from the general population selected by random or quota sampling and used face-to-face interviews or postal surveys. Studies valued between 7 and 198 total states, with 1-23 states valued per respondent. Different model specifications have been proposed for scoring. Some sample or demographic factors, including gender, education, percentage urban population, and national health care expenditure, were associated with differences in observed utilities for moderate or severe health states. . EQ-5D valuation studies conducted to date have varied widely in their design and in the resulting scoring algorithms. Therefore, we propose the Checklist for Reporting Valuation Studies of the EQ-5D (CREATE) for those conducting valuation studies.

  9. 2.5-D frequency-domain viscoelastic wave modelling using finite-element method

    Science.gov (United States)

    Zhao, Jian-guo; Huang, Xing-xing; Liu, Wei-fang; Zhao, Wei-jun; Song, Jian-yong; Xiong, Bin; Wang, Shang-xu

    2017-10-01

    2-D seismic modelling has notable dynamic information discrepancies with field data because of the implicit line-source assumption, whereas 3-D modelling suffers from a huge computational burden. The 2.5-D approach is able to overcome both of the aforementioned limitations. In general, the earth model is treated as an elastic material, but the real media is viscous. In this study, we develop an accurate and efficient frequency-domain finite-element method (FEM) for modelling 2.5-D viscoelastic wave propagation. To perform the 2.5-D approach, we assume that the 2-D viscoelastic media are based on the Kelvin-Voigt rheological model and a 3-D point source. The viscoelastic wave equation is temporally and spatially Fourier transformed into the frequency-wavenumber domain. Then, we systematically derive the weak form and its spatial discretization of 2.5-D viscoelastic wave equations in the frequency-wavenumber domain through the Galerkin weighted residual method for FEM. Fixing a frequency, the 2-D problem for each wavenumber is solved by FEM. Subsequently, a composite Simpson formula is adopted to estimate the inverse Fourier integration to obtain the 3-D wavefield. We implement the stiffness reduction method (SRM) to suppress artificial boundary reflections. The results show that this absorbing boundary condition is valid and efficient in the frequency-wavenumber domain. Finally, three numerical models, an unbounded homogeneous medium, a half-space layered medium and an undulating topography medium, are established. Numerical results validate the accuracy and stability of 2.5-D solutions and present the adaptability of finite-element method to complicated geographic conditions. The proposed 2.5-D modelling strategy has the potential to address modelling studies on wave propagation in real earth media in an accurate and efficient way.

  10. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment.

    Science.gov (United States)

    Wang, Zhaoxi; Claus Henn, Birgit; Wang, Chaolong; Wei, Yongyue; Su, Li; Sun, Ryan; Chen, Han; Wagner, Peter J; Lu, Quan; Lin, Xihong; Wright, Robert; Bellinger, David; Kile, Molly; Mazumdar, Maitreyi; Tellez-Rojo, Martha Maria; Schnaas, Lourdes; Christiani, David C

    2017-07-28

    Neurodevelopment is a complex process involving both genetic and environmental factors. Prenatal exposure to lead (Pb) has been associated with lower performance on neurodevelopmental tests. Adverse neurodevelopmental outcomes are more frequent and/or more severe when toxic exposures interact with genetic susceptibility. To explore possible loci associated with increased susceptibility to prenatal Pb exposure, we performed a genome-wide gene-environment interaction study (GWIS) in young children from Mexico (n = 390) and Bangladesh (n = 497). Prenatal Pb exposure was estimated by cord blood Pb concentration. Neurodevelopment was assessed using the Bayley Scales of Infant Development. We identified a locus on chromosome 8, containing UNC5D, and demonstrated evidence of its genome-wide significance with mental composite scores (rs9642758, p meta = 4.35 × 10-6). Within this locus, the joint effects of two independent single nucleotide polymorphisms (SNPs, rs9642758 and rs10503970) had a p-value of 4.38 × 10-9 for mental composite scores. Correlating GWIS results with in vitro transcriptomic profiles identified one common gene, SLC1A5, which is involved in synaptic function, neuronal development, and excitotoxicity. Further analysis revealed interconnected interactions that formed a large network of 52 genes enriched with oxidative stress genes and neurodevelopmental genes. Our findings suggest that certain genetic polymorphisms within/near genes relevant to neurodevelopment might modify the toxic effects of Pb exposure via oxidative stress.

  11. Association of serum bicarbonate with bone fractures in hemodialysis patients: the mineral and bone disorder outcomes study for Japanese CKD stage 5D patients (MBD-5D).

    Science.gov (United States)

    Kato, Akihiko; Kido, Ryo; Onishi, Yoshihiro; Kurita, Noriaki; Fukagawa, Masafumi; Akizawa, Tadao; Fukuhara, Shunichi

    2014-01-01

    Bone fracture is often complicated in hemodialysis (HD) patients. Metabolic acidosis is related to bone disease and muscle wasting, but it is not known whether acid-base disturbance is associated with the risk of bone fractures. The aim of this study was to clarify the association of serum bicarbonate level with bone fracture in HD patients. Using a subcohort of the Mineral and Bone Disorder Outcomes Study for Japanese CKD Stage 5D Patients (MBD-5D), 890 prevalent HD patients (age: 62 years old, male: 62.8%, duration of dialysis: 8.3 years) with secondary hyperparathyroidism were studied. After measuring predialysis serum bicarbonate at a 2-day interdialytic interval, we prospectively followed them every 3 months, and examined the occurrence of any type of bone fracture or hospitalization due to fracture over a 3-year observation period. Seventy-four bone fractures and 47 hospitalizations due to fracture were observed during the follow-up period. HD patients with serum bicarbonate bicarbonate of 20.0-21.9 mmol/l. A higher bicarbonate level (≥22 mmol/l) was also related to an increased risk of bone fracture. A restricted cubic regression spline disclosed that the higher or the lower than 21.0 mmol/l of serum bicarbonate, the greater the risk for bone fracture. Both a lower level and a higher level of predialysis bicarbonate concentration were associated with risk of bone fracture in HD patients with secondary hyperparathyroidism. © 2014 S. Karger AG, Basel.

  12. A novel 2.5D approach for interfacing with web applications

    OpenAIRE

    Sarkar, Saurabh

    2012-01-01

    Web applications need better user interface to be interactive and attractive. A new approach/concept of dimensional enhancement - 2.5D "a 2D display of a virtual 3D environment", which can be implemented in social networking sites and further in other system applications.

  13. Testing of interposer-based 2.5D integrated circuits

    CERN Document Server

    Wang, Ran

    2017-01-01

    This book provides readers with an insightful guide to the design, testing and optimization of 2.5D integrated circuits. The authors describe a set of design-for-test methods to address various challenges posed by the new generation of 2.5D ICs, including pre-bond testing of the silicon interposer, at-speed interconnect testing, built-in self-test architecture, extest scheduling, and a programmable method for low-power scan shift in SoC dies. This book covers many testing techniques that have already been used in mainstream semiconductor companies. Readers will benefit from an in-depth look at test-technology solutions that are needed to make 2.5D ICs a reality and commercially viable. Provides a single-source guide to the practical challenges in testing of 2.5D ICs; Presents an efficient method to locate defects in a passive interposer before stacking; Describes an efficient interconnect-test solution to target through-silicon vias (TSVs), the redistribution layer, and micro-bumps for shorts, opens, and dela...

  14. Pressure-induced crossing of the core levels in 5d metals

    NARCIS (Netherlands)

    Tal, A.A.; Katsnelson, M.I.; Ekholm, M.; Jonsson, H.J.M.; Dubrovinsky, L.; Dubrovinskaia, N.; Abrikosov, I.A.

    2016-01-01

    A pressure-induced interaction between core electrons, the core-level crossing (CLC) transition, has been observed in hcp Os at P approximate to 400 GPa [L. Dubrovinsky et al., Nature (London) 525, 226 (2015)]. By carrying out a systematic theoretical study for all metals of the 5d series (Hf, Ta,

  15. A 2.5-D Diffraction Tomography Inversion Scheme for Ground Penetrating Radar

    DEFF Research Database (Denmark)

    Meincke, Peter

    1999-01-01

    A new 2.5-D inversion scheme is derived for ground penetrating radar (GPR) that applies to a monostatic fixed-offset measurement configuration. The inversion scheme, which is based upon the first Born approximation and the pseudo-inverse operator, takes rigorously into account the planar air...

  16. Electrically insulating properties of the 5d double perovskite Sr2YOsO6

    Science.gov (United States)

    Li, Jinghua; Wang, Xia; Wang, Hongyuan; Matsushita, Yoshitaka; Alexei, Belik A.; Kolodiazhnyi, Taras; Xu, Gang; Shi, Youguo; Guo, Yanfeng; Yamaura, Kazunari; Chen, Ying

    2017-09-01

    A high-pressure-synthesized double perovskite Sr2YOsO6 was investigated by synchrotron X-ray diffraction and measurements of its magnetic susceptibility, specific heat capacity, complex impedance, and complex dielectric constant. It crystallized into a monoclinic double perovskite structure (P21/n) with complete ordering of the Y and Os atoms. Its magnetic behaviors, including the antiferromagnetic transition temperature (˜52 K), Curie-Weiss effective moment [3.48(5) μB/Os], and Weiss temperature [-350.1(7) K], were close to the respective values of Sr2YOsO6 previously synthesized without an applied pressure of 6 GPa. Transport property measurements revealed that the lower limit of the activation energy was 192(1) meV and the charge gap remained open regardless of the presence of magnetic order, conflicting with the electron delocalization predicted by theoretical calculations. Further consideration, including theoretical and experimental investigations of the roles of spin-orbit coupling and U of the 5d electrons of Os 5d-t2g3, may assist in understanding the general magnetic and insulating behaviors of quasi-half-filled 5d-t2g3oxides in the perovskite category toward the use of 5d double perovskite for magnetic applications.

  17. Structures of the Dehydrogenation Products of Methane Activation by 5d Transition Metal Cations

    NARCIS (Netherlands)

    Lapoutre, V.J.F.; Redlich, B.; Meer, A.F.G.; Oomens, J.; Bakker, J.M.; Sweeney, A.; Mookherjee, A.; Armentrout, P.B.

    2013-01-01

    The activation of methane by gas-phase transition metal cations (M+) has been studied extensively, both experimentally and using density functional theory (DFT). Methane is exothermically dehydrogenated by several 5d metal ions to form [M,C,2H](+) and H-2. However, the structure of the

  18. Structures of the dehydrogenation products of methane activation by 5d transition metal cations

    NARCIS (Netherlands)

    Lapoutre, V. J. F.; Redlich, B.; van der Meer, A. F. G.; Oomens, J.; Bakker, J. M.; Sweeney, A.; Mookherjee, A.; Armentrout, P. B.

    2013-01-01

    The activation of methane by gas-phase transition metal cations (M +) has been studied extensively, both experimentally and using density functional theory (DFT). Methane is exothermically dehydrogenated by several 5d metal ions to form [M,C,2H]+ and H2. However, the structure of the dehydrogenation

  19. Loft CIS analysis 2''-LS-118-AB outside containment penetration S5-D

    Energy Technology Data Exchange (ETDEWEB)

    Morton, D.K.

    1978-09-28

    A stress analysis was performed on the 2''-LS-118-AB pipe system outside containment penetration S5-D. Deadweight, thermal expansion, and seismic loads were considered. The results indicate that this piping will meet ASME Section III, Class 2 requirements provided a U-bolt (S4) is installed as indicated in this report.

  20. Opting for Assets to Enrich Pre-School Learning

    Science.gov (United States)

    Eloff, I.; de Wet, A.

    2009-01-01

    This research entailed an ethnographic study that sought assets and resources to enrich pre-school learning in a community challenged by poverty. The aim of this research was to identify personal and environmental assets that could be used to enrich pre-school learning within this context--instead of focusing on needs and deficiencies. The assets…

  1. The validity of the Shona version of the EQ-5D, of life measure

    Directory of Open Access Journals (Sweden)

    J. M. Jelsma

    2002-02-01

    Full Text Available Introduction: The EQ-5D, a generic health related quality of life measure developed in Europe, has been recently translated into Shona, the language of the majority of Zimbabweans. Although the reliability of the Shona version of the EQ-5D has been established within a community setting, the reliability and validity of the measure within a group of Shona speaking people with disabilities has not been examined.Aim: The aim of the study was to examine the reliability and concurrent validity of the Shona version of the EQ-5D, within the context of a house-to-house survey of disability in a high-density area of Harare, Zimbabwe.Methods: As part of a house-to-house survey of disability in a high-density area in Zimbabwe, 588 Shona speaking subjects with disability/morbidity or their proxies were asked to respond to the Shona version of the EQ-5D questionnaire. Those who were able to understand the concept filled in the visual analogue scale.  A testretest was done to determine the reliability of the EQ-5D.  Timed walking was used to investigate the validity of thedomain of mobility and the International Classification of Impairment, Disability and Handicap Beta Draft  (ICIDH2 was used as the gold standard for usual activities and self care. The concurrent validity of the anxiety/depression domain was determined against the Shona Symptom Questionnaire, which is a validated screen for depression in the Zimbabwe population. No measure of pain could be found which had been validated in Zimbabwe.Data analysis: The Intraclass-correlation  (ICC and Pearson’s correlation co-efficient were used to determine the test re-test reliability of the descriptor section and visual analogue scale of the EQ-5D respectively. The t-test, ANOVA, and post-hoc Scheffe test were used to compare the EQ-5D with the measures of function.Results:Each domain of the Shona EQ-5D demonstrated reliability on the test re-test (ICC ranging from .58 for self care to .85 for

  2. 77 FR 13367 - General Electric-Hitachi Global Laser Enrichment, LLC, Proposed Laser-Based Uranium Enrichment...

    Science.gov (United States)

    2012-03-06

    ... examine and purchase copies of public documents at the NRC's PDR, Room O1-F21, One White Flint North... concentrations up to 8 percent by weight. The enriched uranium would be used to manufacture nuclear fuel for... resources, air quality, geology and soils, water resources, ecological resources, noise, transportation...

  3. Dynamics of test particles and pointlike gyroscopes in the brane world and other 5D models

    Science.gov (United States)

    Seahra, Sanjeev S.

    2002-06-01

    We study the dynamics of test particles and pointlike gyroscopes in 5D manifolds such as those used in the Randall-Sundrum brane world and noncompact Kaluza-Klein models. Our analysis is based on a covariant foliation of the manifold using (3+1)-dimensional spacetime slices orthogonal to the extra dimension, and is hence similar to the Arnowitt-Deser-Misner 3+1 split in ordinary general relativity. We derive gauge invariant equations of motion for freely falling test particles in the 5D and 4D affine parametrizations and contrast these results with previous work concerning the so-called ``fifth force.'' Motivated by the conjectured localization of matter fields on a 3-brane, we derive the form of the classical nongravitational force required to confine particles to a 4D hypersurface and show that the resulting trajectories are geometrically identical to the spacetime geodesics of Einstein's theory. We then discuss the issue of determining the 5D dynamics of a torque-free spinning body in the point-dipole approximation, and then perform a covariant (3+1)+1 decomposition of the relevant formulas (i.e., the 5D Fermi-Walker transport equation) for the cases of freely falling and hypersurface-confined point gyroscopes. In both cases, the 4D spin tensor is seen to be subject to an anomalous torque. We solve the spin equations for a gyroscope confined to a single spacetime section in a simple 5D cosmological model and observe a cosmological variation of the magnitude and orientation of the 4D spin.

  4. Validity, reliability, and responsiveness of the EQ-5D in inflammatory bowel disease in Germany.

    Science.gov (United States)

    Stark, Renee G; Reitmeir, Peter; Leidl, Reiner; König, Hans-Helmut

    2010-01-01

    The EuroQol (EQ)-5D questionnaire is a generic instrument measuring health-related quality of life. Its validity, reliability, and responsiveness were assessed in a large sample of Crohn's disease (CD) and ulcerative colitis (UC) patients. The EQ-5D was completed initially (270 CD and 232 UC subjects) and after 4 weeks (447 subjects) with a transition question rating health change. Responsiveness of EQ visual analog scale (EQ-VAS) and the United Kingdom (UK-index) and German EQ-5D index (EQ-index) scores to reported changes in health was evaluated by standardized response means (SRM) and meaningful differences (MDs). EQ-VAS and EQ-index scores correlated well with disease activity indices and differed significantly between active disease and remission groups. All scores were reliable in test-retest (ICC: EQ-VAS: 0.89; UK-index: 0.76; German EQ-index: 0.72). According to SRM, EQ-VAS was more responsive for deterioration in health than for improvement in health and was more responsive than index scores. Index scores were most responsive for deterioration in health in subjects in remission and for improved health in subjects with active disease. MDs for improved health (EQ-VAS: 10.9; UK EQ-index: 0.076; German EQ-index: 0.050) and deteriorated health (EQ-VAS: -14.4; UK EQ-index: -0.109; German EQ-index: -0.067) were significant, but MD of EQ-VAS also differed significantly according to disease activity. The EQ-5D generates valid, reliable, and responsive preference-based evaluations of health in CD and UC. EQ-VAS scores were more responsive than EQ-5D index scores. Thus, small health differences that are important from the patient's perspective may not be reflected in the EQ-index.

  5. Mapping of the DLQI scores to EQ-5D utility values using ordinal logistic regression.

    Science.gov (United States)

    Ali, Faraz Mahmood; Kay, Richard; Finlay, Andrew Y; Piguet, Vincent; Kupfer, Joerg; Dalgard, Florence; Salek, M Sam

    2017-11-01

    The Dermatology Life Quality Index (DLQI) and the European Quality of Life-5 Dimension (EQ-5D) are separate measures that may be used to gather health-related quality of life (HRQoL) information from patients. The EQ-5D is a generic measure from which health utility estimates can be derived, whereas the DLQI is a specialty-specific measure to assess HRQoL. To reduce the burden of multiple measures being administered and to enable a more disease-specific calculation of health utility estimates, we explored an established mathematical technique known as ordinal logistic regression (OLR) to develop an appropriate model to map DLQI data to EQ-5D-based health utility estimates. Retrospective data from 4010 patients were randomly divided five times into two groups for the derivation and testing of the mapping model. Split-half cross-validation was utilized resulting in a total of ten ordinal logistic regression models for each of the five EQ-5D dimensions against age, sex, and all ten items of the DLQI. Using Monte Carlo simulation, predicted health utility estimates were derived and compared against those observed. This method was repeated for both OLR and a previously tested mapping methodology based on linear regression. The model was shown to be highly predictive and its repeated fitting demonstrated a stable model using OLR as well as linear regression. The mean differences between OLR-predicted health utility estimates and observed health utility estimates ranged from 0.0024 to 0.0239 across the ten modeling exercises, with an average overall difference of 0.0120 (a 1.6% underestimate, not of clinical importance). This modeling framework developed in this study will enable researchers to calculate EQ-5D health utility estimates from a specialty-specific study population, reducing patient and economic burden.

  6. On a boundary-localized Higgs boson in 5D theories.

    Science.gov (United States)

    Barceló, Roberto; Mitra, Subhadip; Moreau, Grégory

    In the context of a simple five-dimensional (5D) model with bulk matter coupled to a brane-localized Higgs boson, we point out a non-commutativity in the 4D calculation of the mass spectrum for excited fermion towers: the obtained expression depends on the choice in ordering the limits, [Formula: see text] (infinite Kaluza-Klein tower) and [Formula: see text] ([Formula: see text] being the parameter introduced for regularizing the Higgs Dirac peak). This introduces the question of which one is the correct order; we then show that the two possible orders of regularization (called I and II) are experimentally equivalent, as both can typically reproduce the measured observables, but that the one with less degrees of freedom (I) could be uniquely excluded by future experimental constraints. This conclusion is based on the exact matching between the 4D and 5D analytical calculations of the mass spectrum - via regularizations of type I and II. Beyond a deeper insight into the Higgs peak regularizations, this matching brings another confirmation of the validity of the 5D mixed formalism. All the conclusions, deduced from regularizing the Higgs peak through a brane shift or a smoothed square profile, are expected to remain similar in realistic models with a warped extra-dimension. The complementary result of the study is that the non-commutativity disappears, both in the 4D and the 5D calculations, in the presence of higher order derivative operators. For clarity, the 4D and 5D analytical calculations, matching with each other, are presented in the first part of the paper, while the second part is devoted to the interpretation of the results.

  7. Reliability and validity of the EQ-5D-5L compared to the EQ-5D-3L in patients with osteoarthritis referred for hip and knee replacement.

    Science.gov (United States)

    Conner-Spady, Barbara L; Marshall, Deborah A; Bohm, Eric; Dunbar, Michael J; Loucks, Lynda; Al Khudairy, Ammar; Noseworthy, Tom W

    2015-07-01

    To assess the test-retest reliability of the EQ-5D-5L (5L) and compare the validity of the 5L and EQ-5D-3L (3L) in osteoarthritis patients referred to an orthopaedic surgeon for total joint replacement. We mailed questionnaires to 306 consecutive patients following referral and a second questionnaire after 2 weeks to assess reliability. Questionnaires included the 5L, EQ-VAS, Short Form-12, Oxford hip and knee scores, pain VAS, and the 3L. We compared the ceiling effect, redistribution properties, convergent and discriminant validity, and discriminatory power of the 5L and 3L. We obtained 176 respondents (response rate 58 %), 60 % female, 64 % knee patients, mean age 65 years (SD 11), with no significant differences between responders versus non-responders. Intraclass correlation coefficients were 0.61-0.77 for the 5L dimensions and 0.87 for the 5L index. For the 3L, most patients used level 2 (some/moderate problems) for mobility (87 %), usual activities (78 %), and pain/discomfort (71 %). In comparison, 5L responses were spread out with only 52, 42, and 50 %, respectively, using the middle level. All convergent validity coefficients were stronger with the 5L (Spearman coefficients 0.51-0.75). Absolute informativity (Shannon's index) showed higher results for all dimensions of the 5L compared with the 3L (average difference 0.74). Relative informativity (Shannon's evenness index) showed an increase from the 3L to the 5L in mobility, usual activities, and pain/discomfort. The 5L provided stronger validity evidence than the 3L, especially for dimensions relevant to this patient population-mobility, usual activities, and pain/discomfort.

  8. Impact of educational level on health-related quality of life (HRQL): results from Germany based on the EuroQol 5D (EQ-5D).

    Science.gov (United States)

    Mielck, Andreas; Reitmeir, Peter; Vogelmann, Martin; Leidl, Reiner

    2013-02-01

    To date, there is hardly any study focussing on the question how the concept of HRQL could deepen our understanding of health inequalities. The study aims at describing this potential by analysing data for adults from Germany. The analyses are based on three national, representative surveys conducted from 2006 to 2008. HRQL was assessed by the EuroQol-5D (EQ-5D), the descriptive part (problems in five dimensions) and the valuation of health by visual analogue scale (VAS) rendering a value between '0' (worst) and '100' (best imaginable). The major independent variable is educational level (high vs. low). Four other variables were included (i.e. age, sex, per capita income and chronic disease). Multivariate analyses were performed by logistic and linear regression. Data were available for 5676 persons aged ≥ 20 years (response rate 73%). The prevalence of 'moderate or severe problems' is especially high in the dimension 'pain/discomfort' (low resp. high educational level: 46.3% resp. 25.0%). The mean VAS-value is 79.8 (low resp. high educational level: 75.3 resp. 83.6). Bivariate and multivariate analyses show that similar differences in VAS-values can be seen even after restricting the analyses to participants with a chronic disease. Empirical analyses concerning HRQL could further our understanding of health inequalities. They indicate that low status groups are faced with a double burden, first by increased levels of health impairments, and second by lower levels of HRQL once health is impaired. Thus, the extent of health inequalities could be underestimated if measures of HRQL are not taken into account.

  9. Can LIGO Directly Detect the Scalar Field Dark Energy of 5D Gravity?

    Science.gov (United States)

    Zhang, Tianxi

    2017-06-01

    The observed acceleration of the present universe is commonly attributed to the existence of dark energy as a dominant component throughout the universe. A direct detection of dark energy has become one of the most important issues in the modern astrophysics and cosmology. Two widely accepted candidates of the dark energy are the cosmological constant Λ and the quintessence. Unlike the cosmological constant, the quintessence is a scalar field Φ that varies throughout spacetime, and has been modelled in various ways such as the four-dimensional (4D) Brans-Dicke scalar-tensor theory of gravitation and the five-dimensional (5D) Kaluza-Klein scalar-vector-tensor theory of gravitation. The scalar field of 5D gravity was shown to be capable of polarizing the space or vacuum and thus can extend the optical length of the path of a laser beam that passes through the polarized space or vacuum. Recently, the author, in terms of his 5D fully covariant Kaluza-Klein scalar-vector-tensor theory of gravitation, has quantitatively related the dielectric constant of the polarized vacuum (and thus the optical length of the path in the polarized vacuum) to the charge-mass ratio of a charged object. This study further demonstrates that the vacuum polarization by the scalar field dark energy of 5D gravity, when the object is highly charged, can be significant enough for the extremely accurate LIGO, which has recently detected first ever the gravitational waves from the binary black hole merger, to directly detect. It is shown that a some-thousand-kilogram sphere electrically charged to tens of kilovolts can polarize the vacuum by its scalar field dark energy and thus extend the optical path length of a laser beam that travels through one LIGO arm with some hundred reflections by approximately 10-18 m, which is one-order higher than that to be detected by the LIGO detectors. Therefore, being added a highly charged sphere into the experimental setup, LIGO may directly discover the

  10. Rapid Traversability Assessment in 2.5D Grid-based Map on Rough Terrain

    Directory of Open Access Journals (Sweden)

    Yi Huang

    2008-11-01

    Full Text Available This paper presents a rapid traversability assessment approach based on an extended 2.5D grid-based representaion of the rough terrain. Stereo vision system is used to perceive the environment surrounding robot. Conventional 2D, 3D and other 2.5D grid maps determine the traversability indices of the grids directly from the sensor feedback, while our approach attempts to address the indices of terrain from multiple grids instead. By analyzing the properties of multiple grids that the robot is to traverse, passable grids are distinguished, which also takes the robot's size into account. Fuzzy logic framework is applied to extract traversabiltiy indices from the terrain characteristics. A soccer robot equipped with a stereo vision system is adopted for experiments. The results show that our map is capable of speeding the process of traversability assessment and providing an autonomous mobile robot with a appropriate representation of 3D uneven terrain profile.

  11. Does the EQ-5D measure quality of life in schizophrenia?

    DEFF Research Database (Denmark)

    Halling Hastrup, Lene; Nordentoft, Merete; Hjorthoej, Carsten

    2011-01-01

    a generic preference based outcome measure, like EQ-5D, in health economic evaluations in order to allow for comparisons of health related quality of life of patient groups across different diseases, providing information particular useful to support health policy decisions and cost-effectiveness analysis......Most health economic evaluations in mental care include outcome measures aimed at specific aspects of health, like symptom improvement, functional improvement and quality of life instead of generic preference based outcome measures. The health economic guidelines (NICE) recommend to include...... in mental health, but only few studies have addressed the correlation between the EQ-5D and a condition-specific quality of life measure in mental health....

  12. Synthetic Study of 2.5-D ATEM Based on Finite Element Method

    DEFF Research Database (Denmark)

    Qiang, Jianke; Zhou, Junjie; Cai, Hongzhu

    2013-01-01

    Based on the regular triangular dissection for finite element method, we implemented the forward modeling of 2.5-D airborne transient electromagnetic method. The 3-D EM field was firstly transformed into Laplace domain and after that we will apply Fourier transform to reduce the dimension from 3-D...... study shows that our numerical solution fits well with the analytical solution for homogeneous and layered earth model. The study also demonstrated the effectiveness of our numerical method....... to 2.5-D. We can obtain the EM field solution in Laplace domain by applying finite element method. The inverse Laplace transform is applied to our solution which finally leads to the airborne EM response in time domain. In compared to the traditional method, we apply our finite element method...

  13. The blue light indicator in rubidium 5S-5P-5D cascade excitation

    Science.gov (United States)

    Raja, Waseem; Ali, Md. Sabir; Chakrabarti, Alok; Ray, Ayan

    2017-07-01

    The cascade system has played an important role in contemporary research areas related to fields like Rydberg excitation, four wave mixing and non-classical light generation, etc. Depending on the specific objective, co or counter propagating pump-probe laser experimental geometry is followed. However, the stepwise excitation of atoms to states higher than the first excited state deals with increasingly much fewer number of atoms even compared to the population at first excited level. Hence, one needs a practical indicator to study the complex photon-atom interaction of the cascade system. Here, we experimentally analyze the case of rubidium 5S → 5P → 5D as a specimen of two-step excitation and highlight the efficacy of monitoring one branch, which emits 420 nm, of associated cascade decay route 5D → 6P → 5S, as an effective monitor of the coherence in the system.

  14. A 5D holographic dark energy in DGP-BRANE cosmology

    Science.gov (United States)

    Farajollahi, H.; Ravanpak, A.

    2014-02-01

    This paper is aimed to investigate 5D holographic dark energy (HDE) in DGP-Brane cosmology by employing a combination of Sne Ia, BAO and CMB observational data and constraining cosmological parameters. The FRW dynamics for the normal branch ( ɛ=+1) solution of induced gravity brane-world model is taken with the assumption that matter in 5D bulk is HDE such that its holographic nature is reproduced effectively in 4D universe. In the HDE model, we used Hubble horizon as IR cutoff instead of future event horizon. This way, while the model predicts current universe acceleration, it also removes the problem of circular reasoning and causality observed in using future event horizon as IR cutoff.

  15. Valuation and Modeling of EQ-5D-5L Health States Using a Hybrid Approach.

    Science.gov (United States)

    Ramos-Goñi, Juan M; Pinto-Prades, Jose L; Oppe, Mark; Cabasés, Juan M; Serrano-Aguilar, Pedro; Rivero-Arias, Oliver

    2017-07-01

    The EQ-5D instrument is the most widely used preference-based health-related quality of life questionnaire in cost-effectiveness analysis of health care technologies. Recently, a version called EQ-5D-5L with 5 levels on each dimension was developed. This manuscript explores the performance of a hybrid approach for the modeling of EQ-5D-5L valuation data. Two elicitation techniques, the composite time trade-off, and discrete choice experiments, were applied to a sample of the Spanish population (n=1000) using a computer-based questionnaire. The sampling process consisted of 2 stages: stratified sampling of geographic area, followed by systematic sampling in each area. A hybrid regression model combining composite time trade-off and discrete choice data was used to estimate the potential value sets using main effects as starting point. The comparison between the models was performed using the criteria of logical consistency, goodness of fit, and parsimony. Twenty-seven participants from the 1000 were removed following the exclusion criteria. The best-fitted model included 2 significant interaction terms but resulted in marginal improvements in model fit compared to the main effects model. We therefore selected the model results with main effects as a potential value set for this methodological study, based on the parsimony criteria. The results showed that the main effects hybrid model was consistent, with a range of utility values between 1 and -0.224. This paper shows the feasibility of using a hybrid approach to estimate a value set for EQ-5D-5L valuation data.

  16. 5D maximally supersymmetric Yang-Mills in 4D superspace. Applications

    Energy Technology Data Exchange (ETDEWEB)

    McGarrie, Moritz

    2013-03-15

    We reformulate 5D maximally supersymmetric Yang-Mills in 4D Superspace, for a manifold with boundaries. We emphasise certain features and conventions necessary to allow for supersymmetric model building applications. Finally we apply the holographic interpretation of a slice of AdS and show how to generate Dirac soft masses between external source fields, as well as kinetic mixing, as a boundary effective action.

  17. Developing preference-based measures for diabetes: DHP-3D and DHP-5D.

    Science.gov (United States)

    Mulhern, B; Labeit, A; Rowen, D; Knowles, E; Meadows, K; Elliott, J; Brazier, J

    2017-09-01

    The aim of this study was to develop two diabetes-specific preference-based measures [the Diabetes Health Profile-3 Dimension (DHP-3D) and the Diabetes Health Profile-5 Dimension (DHP-5D)] for use in the calculation of Quality Adjusted Life Years, a key outcome in economic evaluation. These measures were based on the non-preference-based instrument the Diabetes Health Profile. For DHP-3D, psychometric and Rasch analyses were used to develop a health state classification system based on the Diabetes Health Profile-18 (DHP-18). The DHP-5D added two dimensions to the DHP-3D to extend the range of impacts measured. Each classification system was valued by 150 general public respondents in the United Kingdom using Time Trade Off (TTO). Multivariate regression was used to estimate utility value sets. The matched dimensions across each measure were compared using z-score tests. The DHP-3D included three dimensions defined as mood, eating and social limitations, and the DHP-5D added dimensions defined as hypoglycaemic attacks and vitality. For both, the random effects generalized least squares regression model produced consistent value sets, with the DHP-3D and DHP-5D ranging from 0.983 (best state) to 0.717 (worst state), and 0.979 to 0.618 respectively. The addition of the two extra dimensions leads to significant differences for the more severe levels of each matched dimension. We have developed two diabetes-specific preference-based measures that, subject to psychometric assessment, can be used to provide condition-specific utility values to complement generic utilities from more widely validated measures such as the EuroQol-5 Dimension. © 2017 Diabetes UK.

  18. Oxygen enrichment incineration

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Guk; Yang, Hee Chul; Park, Geun Il; Kim, Joon Hyung

    2000-10-01

    Oxygen enriched combustion technology has recently been used in waste incineration. To apply the oxygen enrichment on alpha-bearing waste incineration, which is being developed, a state-of-an-art review has been performed. The use of oxygen or oxygen-enriched air instead of air in incineration would result in increase of combustion efficiency and capacity, and reduction of off-gas product. Especially, the off-gas could be reduced below a quarter, which might reduce off-gas treatment facilities, and also increase an efficiency of off-gas treatment. However, the use of oxygen might also lead to local overheating and high nitrogen oxides (NOx) formation. To overcome these problems, an application of low NOx oxy-fuel burner and recycling of a part of off-gas to combustion chamber have been suggested.

  19. Hidden hyperchaos and electronic circuit application in a 5D self-exciting homopolar disc dynamo.

    Science.gov (United States)

    Wei, Zhouchao; Moroz, Irene; Sprott, J C; Akgul, Akif; Zhang, Wei

    2017-03-01

    We report on the finding of hidden hyperchaos in a 5D extension to a known 3D self-exciting homopolar disc dynamo. The hidden hyperchaos is identified through three positive Lyapunov exponents under the condition that the proposed model has just two stable equilibrium states in certain regions of parameter space. The new 5D hyperchaotic self-exciting homopolar disc dynamo has multiple attractors including point attractors, limit cycles, quasi-periodic dynamics, hidden chaos or hyperchaos, as well as coexisting attractors. We use numerical integrations to create the phase plane trajectories, produce bifurcation diagram, and compute Lyapunov exponents to verify the hidden attractors. Because no unstable equilibria exist in two parameter regions, the system has a multistability and six kinds of complex dynamic behaviors. To the best of our knowledge, this feature has not been previously reported in any other high-dimensional system. Moreover, the 5D hyperchaotic system has been simulated using a specially designed electronic circuit and viewed on an oscilloscope, thereby confirming the results of the numerical integrations. Both Matlab and the oscilloscope outputs produce similar phase portraits. Such implementations in real time represent a new type of hidden attractor with important consequences for engineering applications.

  20. Analysis of ~21.5 d Period in Ionospheric and Solar Indices during 2011

    Directory of Open Access Journals (Sweden)

    YAO Yibin

    2017-01-01

    Full Text Available By using Fourier transform, the spectrum of total electron content(TEC data, relative sunspot number(RSSN, solar extreme ultraviolet(EUV flux in 0.1~50 nm and 26~34 nm were performed to study the ~27 d period in solar-terrestrial environment. A~21.5 d period was found in TEC and solar indices, while geomagnetic indices showed no sign of this period. We infer that the ~21.5 d period could combined effects of solar rotation and active region evolution. Results of the past few solar cycles show that 21~23 d of quasi-periodic signal will appear in the rising phase of a solar cycle. Using the solar active regions located in the[-10°, 10°] slice, it is further confirmed that the ~21.5 d period observed in 2011 may be caused by the joint effects of solar active region complex and solar rotation. GIM data were used to study the global distribution of the ~27 d period oscillation.

  1. 4D spacetimes embedded in 5D light-like Kasner universes

    CERN Document Server

    de Leon, J Ponce

    2009-01-01

    We consider spatially homogeneous, anisotropic cosmological models in 5D whose line element can be written as $dS^2 = {\\cal{A}}(u, v)du dv - {\\cal{B}}_{i j}(u, v)dx^{i}dx^{j}$, $(i, j = 1, 2, 3)$, where $u$ and $v$ are light-like coordinates. In the case where ${\\cal{B}}_{i j}$ is diagonal, we construct three families of analytic solutions to the 5D vacuum field equations $R_{AB} = 0$ $ (A, B = 0, 1, 2, 3, 4)$. Among them, there is a family of self-similar homothetic solutions that contains, as a particular case, the so-called light-like Kasner universes. In this work we provide a detailed study of the different types of 4D scenarios that can be embedded in such universes. For the sake of generality of the discussion, and applicability of the results, in our analysis we consider the two versions of non-compactified 5D relativity in vogue, viz., braneworld theory and induced matter theory. We find a great variety of cosmological models in 4D which are anisotropic versions of the FRW ones. We obtain models on t...

  2. EPIC Trial: education programme impact on serum phosphorous control in CKD 5D patients on hemodialysis

    Directory of Open Access Journals (Sweden)

    Carmen Tzanno Branco Martins

    Full Text Available Abstract Introduction: In stage 5D chronic kidney disease (CKD 5D patients, the encouragement of treatment adherence by health professionals is a significant clinical challenge. Objectives: This study evaluates the impact of a nutritional education programme on hyperphosphatemia, utilizing the transtheoretical model of behavior change (TMBC. Subjects and Methods: A prospective interventional study comprising 179 CKD 5D patients with hypophosphatemia. The 4-month educational programme took place during dialysis sessions. Demographic and laboratory data were evaluated, whilst the TMBC was utilized both pre- and post-intervention. Results: 132 patients showed a positive change and significant reduction in phosphate levels, whilst 47 patients showed a negative change and little reduction in phosphate levels. Positive changes were identified at different levels of literacy. 117/179 participants had ongoing treatment with sevelamer throughout the trial period. 61 patients with intact parathyroid hormone (iPTH 300 pg/ml also showed a decrease in phosphate levels. Conclusions: Nutritional education programmes can achieve excellent results when appropriately applied. An education programme may be effective across different literacy levels.

  3. Uranium Conversion & Enrichment

    Energy Technology Data Exchange (ETDEWEB)

    Karpius, Peter Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-06

    The isotopes of uranium that are found in nature, and hence in ‘fresh’ Yellowcake’, are not in relative proportions that are suitable for power or weapons applications. The goal of conversion then is to transform the U3O8 yellowcake into UF6. Conversion and enrichment of uranium is usually required to obtain material with enough 235U to be usable as fuel in a reactor or weapon. The cost, size, and complexity of practical conversion and enrichment facilities aid in nonproliferation by design.

  4. Uranium enrichment management review: summary of analysis

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    In May 1980, the Assistant Secretary for Resource Applications within the Department of Energy requested that a group of experienced business executives be assembled to review the operation, financing, and management of the uranium enrichment enterprise as a basis for advising the Secretary of Energy. After extensive investigation, analysis, and discussion, the review group presented its findings and recommendations in a report on December 2, 1980. The following pages contain background material on which that final report was based. This report is arranged in chapters that parallel those of the uranium enrichment management review final report - chapters that contain summaries of the review group's discussion and analyses in six areas: management of operations and construction; long-range planning; marketing of enrichment services; financial management; research and development; and general management. Further information, in-depth analysis, and discussion of suggested alternative management practices are provided in five appendices.

  5. 2.5D complex resistivity modeling and inversion using unstructured grids

    Science.gov (United States)

    Xu, Kaijun; Sun, Jie

    2016-04-01

    The characteristic of complex resistivity on rock and ore has been recognized by people for a long time. Generally we have used the Cole-Cole Model(CCM) to describe complex resistivity. It has been proved that the electrical anomaly of geologic body can be quantitative estimated by CCM parameters such as direct resistivity(ρ0), chargeability(m), time constant(τ) and frequency dependence(c). Thus it is very important to obtain the complex parameters of geologic body. It is difficult to approximate complex structures and terrain using traditional rectangular grid. In order to enhance the numerical accuracy and rationality of modeling and inversion, we use an adaptive finite-element algorithm for forward modeling of the frequency-domain 2.5D complex resistivity and implement the conjugate gradient algorithm in the inversion of 2.5D complex resistivity. An adaptive finite element method is applied for solving the 2.5D complex resistivity forward modeling of horizontal electric dipole source. First of all, the CCM is introduced into the Maxwell's equations to calculate the complex resistivity electromagnetic fields. Next, the pseudo delta function is used to distribute electric dipole source. Then the electromagnetic fields can be expressed in terms of the primary fields caused by layered structure and the secondary fields caused by inhomogeneities anomalous conductivity. At last, we calculated the electromagnetic fields response of complex geoelectric structures such as anticline, syncline, fault. The modeling results show that adaptive finite-element methods can automatically improve mesh generation and simulate complex geoelectric models using unstructured grids. The 2.5D complex resistivity invertion is implemented based the conjugate gradient algorithm.The conjugate gradient algorithm doesn't need to compute the sensitivity matrix but directly computes the sensitivity matrix or its transpose multiplying vector. In addition, the inversion target zones are

  6. Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with somatoform disorders

    Directory of Open Access Journals (Sweden)

    Brettschneider Christian

    2013-01-01

    Full Text Available Abstract Background The EQ-5D is a generic questionnaire providing a preference-based index score applicable to cost-utility analysis. This is the first study to validate the EQ-5D in patients with somatoform disorders. Methods Data of the EQ-5D descriptive system, the British and the German EQ-5D index and the EQ Visual Analogue Scale, the Patient Health Questionnaire 15, the Patient Health Questionnaire 9, the Whiteley Index 7 and the Short Form 36 were collected from 294 patients at baseline, 244 at 6 months and 256 at 12 months after baseline. The discriminative ability of the EQ-5D was evaluated by comparison with a general population sample and by the ability to distinguish between different symptom severities. Convergent validity was analysed by assessing associations between the EQ-5D and the other instruments. Responsiveness was evaluated by analysing the effects on scores between two measurements in groups of patients reporting worse, same or better health. The Bonferroni correction was employed. Results For all items of the EQ-5D except ‘self-care’, patients with somatoform disorders reported more problems than the general population. The EQ-5D showed discriminative ability in patients with different symptom severities. For nearly all reference instruments there were significant differences in mean scores between respondents with and without problems in the various EQ-5D items and strong correlations with the EQ Visual Analogue Scale and the EQ-5D index scores. Evidence for the responsiveness of the EQ-5D could only be found for patients with better health; effects were medium at the utmost. Conclusions The EQ-5D showed a considerable validity and a limited responsiveness in patients with somatoform disorders. Trial registration Current Controlled Trials ISRCTN55280791

  7. The effect of health state selection on the valuation of EQ-5D.

    Science.gov (United States)

    Chuang, Ling-Hsiang; Kind, Paul

    2011-01-01

    Many aspects of valuation s are poorly understood, and the size and composition of health states used in valuation studies vary widely. Our aims were to investigate the impact of the selection of a subset of EQ-5D health states in generating a set of visual analog scale (VAS)-based values. Our aims were to investigate the optimal number of health states, the sample size required per health state, and which combinations of health states are required to establish a EQ-5D VAS value set. Data were drawn from a United Kingdom (UK) general population postal survey in which all health states defined by EQ-5D were evaluated using VAS. We used a simulation approach to address each question, and the performance of each estimation model was assessed by the average value of the mean absolute errors. Despite the constraint of the small sample size in the study dataset, the results suggest that the optimal number of states for a valuation study is 32, 100 observations per health state were sufficient, and multiple subsets of health states were feasible. Selecting health states not included in the "Measurement and Valuation of Health" dataset in valuation studies is quite specifically encouraged. However, it remains prudent to ensure that the selection of health states covers as wide a range of severity as possible. Setting the number of observations per health state to 150 might allow for correction of any errors in data collection or processing. The extent to which the results of this study based on VAS valuation data can be safely generalized to the design of time tradeoff valuation studies remains an open question.

  8. 4D spacetimes embedded in 5D light-like Kasner universes

    Energy Technology Data Exchange (ETDEWEB)

    Ponce de Leon, J, E-mail: jpdel@ltp.upr.clu.ed, E-mail: jpdel1@hotmail.co [Laboratory of Theoretical Physics, Department of Physics University of Puerto Rico, PO Box 23343, San Juan, PR 00931 (Puerto Rico)

    2009-09-21

    We consider spatially homogeneous, anisotropic cosmological models in 5D whose line element can be written as dS{sup 2} =A(u, v) du dv -B{sub ij}(u, v) dx{sup i} dx{sup j}, (i, j = 1, 2, 3), where u and v are light-like coordinates. In the case where B{sub ij} is diagonal, we construct three families of analytic solutions to the 5D vacuum field equations R{sub AB} = 0 (A, B = 0, 1, 2, 3, 4). Among them, there is a family of self-similar homothetic solutions that contains, as a particular case, the so-called light-like Kasner universes. In this work, we provide a detailed study of the different types of 4D scenarios that can be embedded in such universes. For the sake of generality of the discussion, and applicability of the results, in our analysis we consider the two versions of non-compactified 5D relativity in vogue, namely braneworld theory and induced matter theory. We find a great variety of cosmological models in 4D which are anisotropic versions of the FRW ones. We obtain models on the brane with a non-vanishing cosmological term LAMBDA{sub (4)}, which inflate a la de Sitter without satisfying the classical false-vacuum equation of state. Using the symmetry of the solutions, we construct a class of non-static vacuum solutions on the brane. We also develop static pancake-like distributions where the matter is concentrated in a thin surface (near z = 0), similar to those proposed by Zel'dovich for the shape of the first collapsed objects in an expanding anisotropic universe. The solutions discussed here can be applied in a variety of physical situations.

  9. 2.5D Modeling of TEM Data Applied to Hidrogeological Studies in PARANÁ Basin, Brazil

    Science.gov (United States)

    Bortolozo, C. A.; Porsani, J. L.; Santos, F. M.

    2013-12-01

    The transient electromagnetic method (TEM) is used all over the world and has shown great potential in hydrological, hazardous waste site characterization, mineral exploration, general geological mapping, and geophysical reconnaissance. However, the behavior of TEM fields are very complex and is not yet fully understood. Forward modeling is one of the most common and effective methods to understand the physical behavior and significance of the electromagnetics responses of a TEM sounding. Until now, there are a limited number of solutions for the 2D forward problem for TEM. More rare are the descriptions of a three-component response of a 3D source over 2D earth, which is the so-called 2.5D. The 2.5D approach is more realistic than the conventional 2D source previous used, once normally the source cannot be realistic represented for a 2D approximation (normally source are square loops). At present the 2.5D model represents the only way of interpreting TEM data in terms of a complex earth, due to the prohibitive amount of computer time and storage required for a full 3D model. In this work we developed a TEM modeling program for understanding the different responses and how the magnetic and electric fields, produced by loop sources at air-earth interface, behave in different geoelectrical distributions. The models used in the examples are proposed focusing hydrogeological studies, once the main objective of this work is for detecting different kinds of aquifers in Paraná sedimentary basin, in São Paulo State - Brazil. The program was developed in MATLAB, a widespread language very common in the scientific community.

  10. Development of the web-based Spanish and Catalan versions of the Euroqol 5D-Y (EQ-5D-Y) and comparison of results with the paper version

    NARCIS (Netherlands)

    N. Robles (Noemí); L. Rajmil (Luis); D. Rodriguez-Arjona (Dolors); M. Azuara (Marta); F. Codina (Francisco); H. Raat (Hein); U. Ravens-Sieberer (Ulrike); M. Herdman (Michael)

    2015-01-01

    textabstractBackground: The objectives of the study were to develop web-based Spanish and Catalan versions of the EQ-5D-Y, and to compare scores and psychometric properties with the paper version. Methods: Web-based and paper versions of EQ-5D-Y were included in a cross-sectional study in Palafolls

  11. Flavor-changing decays of the top quark in 5D warped models

    OpenAIRE

    Diaz-Furlong, Alfonso; Frank, Mariana; Pourtolami, Nima; Toharia, Manuel; Xoxocotzi, Reyna

    2016-01-01

    We study flavor changing neutral current decays of the top quark in the context of general warped extra dimensions, where the five dimensional metric is slightly modified from 5D anti-de-Sitter (AdS$_5$). These models address the Planck-electroweak hierarchies of the Standard Model $and$ can obey all the low energy flavor bounds and electroweak precision tests, while allowing the scale of new physics to be at the TeV level, and thus within the reach of the LHC at Run II. We perform the calcul...

  12. 4d/5d Correspondence for the Black Hole Potential and its Critical Points

    CERN Document Server

    Ceresole, A; Marrani, A

    2007-01-01

    We express the d=4, N=2 black hole effective potential for cubic holomorphic F functions and generic dyonic charges in terms of d=5 real special geometry data. The 4d critical points are computed from the 5d ones, and their relation is elucidated. For symmetric spaces, we identify the BPS and non-BPS classes of attractors and the respective entropies. These are related by simple formulae, interpolating between four and five dimensions, depending on the volume modulus and on the 4d magnetic (or electric) charges, and holding true also for generic field configurations and for non-symmetric cubic geometries.

  13. Agent-Based Modelling applied to 5D model of the HIV infection

    Directory of Open Access Journals (Sweden)

    Toufik Laroum

    2016-12-01

    The simplest model was the 3D mathematical model. But the complexity of this phenomenon and the diversity of cells and actors which affect its evolution requires the use of new approaches such as multi-agents approach that we have applied in this paper. The results of our simulator on the 5D model are promising because they are consistent with biological knowledge’s. Therefore, the proposed approach is well appropriate to the study of population dynamics in general and could help to understand and predict the dynamics of HIV infection.

  14. Frontiers of 4d- and 5d-transition metal oxides

    CERN Document Server

    Cao, Gang

    2013-01-01

    This book is aimed at advanced undergraduates, graduate students and other researchers who possess an introductory background in materials physics and/or chemistry, and an interest in the physical and chemical properties of novel materials, especially transition metal oxides.New materials often exhibit novel phenomena of great fundamental and technological importance. Contributing authors review the structural, physical and chemical properties of notable 4d- and 5d-transition metal oxides discovered over the last 10 years. These materials exhibit extraordinary physical properties that differ s

  15. Psychometric properties of the EuroQol Five Dimensional Questionnaire (EQ-5D-3L) in caregivers of autistic children.

    Science.gov (United States)

    Khanna, Rahul; Jariwala, Krutika; Bentley, John P

    2013-12-01

    This study aimed to ascertain the psychometric properties of EuroQol Five Dimensional Questionnaire (EQ-5D-3L) in primary caregivers of children with autism. The convergent validity, discriminant validity, known-groups validity, internal consistency reliability, and floor and ceiling effects of EQ-5D-3L were analyzed. A cross-sectional design was used for study purposes. Through an online survey, relevant study information was collected from 316 primary caregivers of children with autism. Study participants were from families of children with autism living in the United States who were registered with the Interactive Autism Network. Convergent validity of the EQ-5D-3L was assessed through its correlation with other measures of similar constructs. Discriminant validity was assessed by observing the correlation of EQ-5D-3L domains with theoretically unrelated constructs. Known-groups validity was tested by comparing EQ-5D-3L index and visual analog scale (VAS) scores across levels of autism severity among the care recipients. Internal consistency reliability of EQ-5D-3L was tested. Lastly, floor and ceiling effects of EQ-5D-3L were assessed. More than 60 % of participants reported problems of 'anxiety/depression.' Convergent and discriminant validity of the EQ-5D-3L was good. Significant correlation (convergent validity) was observed among EQ-5D-3L index and VAS and (SF-12v2) physical component summary and mental component summary scores. Caregivers' EQ-5D-3L index and VAS scores varied by levels of autism severity among care recipients, providing evidence of known-groups validity. Reliability assessed through Cronbach's alpha was less than satisfactory; however, corrected item-total correlations were adequate. The EQ-5D-3L is a psychometrically sound tool to elicit health state preferences among caregivers of children with autism.

  16. Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders

    Directory of Open Access Journals (Sweden)

    Heinrich Sven

    2010-05-01

    Full Text Available Abstract Background The EQ-5D is a generic questionnaire which generates a health profile as well as index scores for health-related quality of life that may be used in cost-utility analysis. Aims of the study To examine validity and responsiveness of the EQ-5D in patients with anxiety disorders. Methods 389 patients with anxiety disorders completed the EQ-5D at baseline and 6-month follow-up. Subjective measures of quality of life (WHOQOL-BREF and psychopathology (BAI, BDI-II, BSQ, ACQ, MI were used for comparison. Validity was analyzed by assessing associations between EQ-5D scores and related other scores. Responsiveness was analyzed by calculating effect sizes of differences in scores between baseline and follow-up for 3 groups indicating more, constant or less anxiety. Meaningful difference scores for shifting to less or more anxiety were derived by means of regression analysis. Results 88.4% of respondents reported problems in at least one of the EQ-5D dimension at baseline; the mean EQ VAS score was 63.8. The EQ-5D dimension most consistently associated with the measures used for comparison was 'anxiety/depression'. EQ VAS and EQ-5D index scores were highly correlated (|r|>0.5 with scores of the WHOQOL-BREF dimensions 'physical', 'mental' and 'overall' as well as BAI and BDI-II. The EQ-5D index tended to be the most responsive score. Standardized meaningful difference scores were not significantly different between EQ VAS, EQ-5D index and measures used for comparison. Conclusions The EQ-5D seems to be reasonably valid and moderately responsive in patients with anxiety disorders. The EQ-5D index may be suitable for calculating QALYs in economic evaluation of health care interventions for patients with anxiety disorders. Trial registration Current Controlled Trials ISRCTN15716049

  17. Phosphopeptide enrichment by IEF.

    Science.gov (United States)

    Maccarrone, Giuseppina; Kolb, Nikolaus; Teplytska, Larysa; Birg, Isabel; Zollinger, Richard; Holsboer, Florian; Turck, Christoph W

    2006-11-01

    In our efforts to improve the identification of phosphopeptides by MS we have used peptide IEF on IPG strips. Phosphopeptides derived from trypsin digests of single proteins as well as complex cellular protein mixtures can be enriched by IEF and recovered in excellent yields at the acidic end of an IPG strip. IPG peptide fractionation in combination with MS/MS analysis has allowed us to identify phosphopeptides from tryptic digests of a cellular protein extract.

  18. Solution and dynamics of a fractional-order 5-D hyperchaotic system with four wings

    Science.gov (United States)

    Zhang, Limin; Sun, Kehui; He, Shaobo; Wang, Huihai; Xu, Yixin

    2017-01-01

    Based on the Adomian decomposition method (ADM), the numerical solution of a fractional-order 5-D hyperchaotic system with four wings is investigated. Dynamics of the system are analyzed by means of phase diagram, bifurcation diagram, Lyapunov exponents spectrum and chaos diagram. The method of one-dimensional linear path through the multidimensional parameter space is proposed to observe the evolution law of the system dynamics with parameters varying. The results illustrate that the system has abundant dynamical behaviors. Both the system order and parameters can be taken as bifurcation parameters. The phenomenon of multiple attractors is found, which means that some attractors are generated simultaneously from different initial values. The spectral entropy (SE) algorithm is applied to estimate the fractional-order system complexity, and we found that the complexity decreases with the increasing of system order. In order to verify the reliability of numerical solution, the fractional-order 5-D system with four wings is implemented on a DSP platform. The phase portraits of fractional-order system generated on DSP agree well with those obtained by computer simulations. It is shown that the fractional-order hyperchaotic system is a potential model for application in the field of chaotic secure communication.

  19. Testing mapping algorithms of the cancer-specific EORTC QLQ-C30 onto EQ-5D in malignant mesothelioma

    NARCIS (Netherlands)

    D.T. Arnold (David); D. Rowen (Donna); M.M. Versteegh (Matthijs); A. Morley (Anna); C.E. Hooper (Clare); N.A. Maskell (Nicholas)

    2015-01-01

    markdownabstract__Background:__ In order to estimate utilities for cancer studies where the EQ-5D was not used, the EORTC QLQ-C30 can be used to estimate EQ-5D using existing mapping algorithms. Several mapping algorithms exist for this transformation, however, algorithms tend to lose accuracy in

  20. Synthesis and biological evaluation of some novel urea and thiourea derivatives of isoxazolo[4,5-d]pyridazine and structurally related thiazolo[4,5-d]pyridazine as antimicrobial agents.

    Science.gov (United States)

    Faidallah, Hassan M; Rostom, Sherif A F; Basaif, Salem A; Makki, Mohammed S T; Khan, Khalid A

    2013-11-01

    This study reports the synthesis of some novel isoxazolo[4,5-d]pyridazines and structurally related thiazolo[4,5-d]pyridazines, and their biological evaluation as antimicrobial agents. The proposed compounds were designed to contain pharmacophores such as urea, thiourea, sulfonylurea (thiourea) and some derived functionalities that are believed to contribute to the anticipated biological activities. The results revealed that 25 compounds displayed broad spectrum of antibacterial activity, with greater inhibitory effect on the growth of the tested Gram positive strains compared to Gram negative ones. Moreover, 14 compounds were able to produce appreciable growth inhibitory activity against Candida albicans fungus when compared to Clotrimazole. Most of the tested isoxazolo[4,5-d]pyridazines displayed better antimicrobial profile than their corresponding thiazolo[4,5-d]pyridazine congeners. Four compounds namely, p-(3,7-dimethyl-4-oxo-4H-isoxazolo [4,5-d]pyridazine-5-yl)benzenesulfonylthioureas (11c-d), 3-substituted-2-[p-(3,7-dimethyl-4-oxo-4H-isoxazolo[4,5-d]pyridazine-5-yl)-benzene-sufonylimino]-4-oxothiazolidines (13d) and p-(2,7-dimethyl-4-oxo-4H-thiazolo[4,5-d]pyridazin-5-yl)benzenesulfonylthiourea (24c) were found to be most active antimicrobial members in present study.

  1. Does the EQ-5D capture the concerns measured by the Palliative care Outcome Scale? Mapping the Palliative care Outcome Scale onto the EQ-5D using statistical methods.

    Science.gov (United States)

    Dzingina, Mendwas D; McCrone, Paul; Higginson, Irene J

    2017-09-01

    The main measure to generate utility data for economic evaluations is the EQ-5D, but no study has tested whether or how to map from palliative care measures to the EQ-5D. To assess the level of conceptual overlap between palliative outcomes and the EQ-5D, and the feasibility of mapping between them to obtain utilities for the Palliative care Outcome Scale. A cross-sectional secondary analysis of data from three studies. Patients receiving palliative care and bereaved relatives, recruited from three tertiary National Health Service hospitals in South London. The overlap between both measures was assessed using principal component analysis. The Palliative care Outcome Scale was mapped onto the EQ-5D using three regression models. Spearman's correlations between both instruments were low (mean rho = 0.11). The principal component analysis showed the Palliative care Outcome Scale is associated with only two EQ-5D dimensions (pain; and anxiety/depression). No Palliative care Outcome Scale items loaded onto the mobility, self-care and usual activities dimensions of the EQ-5D. The mapping models performed poorly at predicting utilities from Palliative care Outcome Scale data (mean absolute error >0.3 and R 2 Palliative care Outcome Scale responses. Differences between the Palliative care Outcome Scale and the EQ-5D do not undermine the qualities of either instrument when used for their own purposes. However, due to conceptual differences, the EQ-5D does not capture some of the concerns measured by the Palliative care Outcome Scale, and therefore, mapping onto the EQ-5D is unlikely to provide an appropriate basis for estimating utilities for conducting economic evaluations in palliative care studies.

  2. Quality of life profile of general Vietnamese population using EQ-5D-5L.

    Science.gov (United States)

    Nguyen, Long Hoang; Tran, Bach Xuan; Hoang Le, Quynh Ngoc; Tran, Tung Thanh; Latkin, Carl A

    2017-10-11

    Health-related quality of life (HRQOL) is a vital benchmark to assess the effects of health interventions and policies. Measuring HRQOL of the general population is essential to establish a reference for health outcomes evaluations. However, evidence on HRQOL of general populations in low and middle income countries is very limited. This study aimed to measure HRQOL of the Vietnamese population by using the EuroQol-5 dimensions-5 levels (EQ-5D-5L) instrument and determine its associated factors. A cross-sectional study was performed in Hanoi with 1571 residences in Hanoi, the capital city of Vietnam. EQ-5D-5L and EQ- visual analogue scale (EQ-VAS) were used to assess HRQOL. Potential covariates included socio-demographic characteristics, having acute symptoms in the last four weeks, chronic diseases in the last three months, having multiple health issues, and health service utilisation in the last twelve months. A generalized linear model was employed to identify the association between HRQOL and covariates. Overall, the mean EQ-5D utility index was 0.91 (SD = 0.15), and the mean EQ-VAS score was 87.4 (SD = 14.3). The highest proportion of respondents reporting any problems was in Usual activities (24.3%), followed by Anxiety/Depression (15.2%) and Pain/Discomfort (10.0%), while the lowest percentage was in Self-care (2.5%). Lower HRQOL composite scores were related to unemployment, lower income, higher education, living in urban areas, having chronic diseases, having multiple health issues and using health service. For any health problem self-reported by respondents, the health utility reduced by 0.02 (respiratory diseases) to 0.15 (musculoskeletal diseases). Health utility of the general population and reductions for self-reported health problems in this study are useful for future population health evaluations and comparisons. It also informs the development of interventions to reduce health problems of the general population.

  3. Spin coating and plasma process for 2.5D integrated photonics on multilayer polymers

    Energy Technology Data Exchange (ETDEWEB)

    Zebda, A. [Institut de Physique de Rennes, IPR UMR CNRS 6251, Universite de Rennes I, 35042 Rennes (France); Camberlein, L. [Laboratoire d' Acoustique de l' Universite du Maine, Micro-Cap-Ouest, LAUM-UMR CNRS 6613, 72000 Le Mans (France); Beche, B. [Institut de Physique de Rennes, IPR UMR CNRS 6251, Universite de Rennes I, 35042 Rennes (France)], E-mail: bruno.beche@univ-rennes1.fr; Gaviot, E. [Laboratoire d' Acoustique de l' Universite du Maine, Micro-Cap-Ouest, LAUM-UMR CNRS 6613, 72000 Le Mans (France); Beche, E. [PROMES UPR CNRS 8521 - Odeillo 66125 Font-Romeu (France); Duval, D. [Institut de Physique de Rennes, IPR UMR CNRS 6251, Universite de Rennes I, 35042 Rennes (France); Zyss, J. [IFR d' Alembert, Laboratoire de Photonique Quantique et Moleculaire, ENS Cachan, LPQM-UMR CNRS 8537, 94235 Cachan (France); Jezequel, G.; Solal, F.; Godet, C. [Institut de Physique de Rennes, IPR UMR CNRS 6251, Universite de Rennes I, 35042 Rennes (France)

    2008-10-01

    Polymer spin coating, surface plasma treatment and selective UV-lithography processes have been developed to realize 2.5D photonic micro-resonators, made of disk- or ring-shaped upper rib waveguides, using common polymers such as SU8 (biphenol A ether glycidyl), PS233 (polymeric silane) and SOG (siloxane Spin on Glass). Both oxygen and argon plasma treatments, applied to PS233 and SOG before spin-coating the SU8, improve substantially the grip of multilayer devices (SU8 / PS233 or SU8 / SOG). Surface energy components derived from contact angle measurements have been used to optimize the processing conditions. In such integrated photonic devices, the both single-electromagnetic-modes called transverse electric (TE{sub 00}) and transverse magnetic (TM{sub 00}) have been excited in a SU8 micro-disk, with a single mode propagation strongly localized near the edge of the disk (i.e. the so called whispering gallery modes)

  4. 2.5D Inversion Algorithm of Frequency-Domain Airborne Electromagnetics with Topography

    Directory of Open Access Journals (Sweden)

    Jianjun Xi

    2016-01-01

    Full Text Available We presented a 2.5D inversion algorithm with topography for frequency-domain airborne electromagnetic data. The forward modeling is based on edge finite element method and uses the irregular hexahedron to adapt the topography. The electric and magnetic fields are split into primary (background and secondary (scattered field to eliminate the source singularity. For the multisources of frequency-domain airborne electromagnetic method, we use the large-scale sparse matrix parallel shared memory direct solver PARDISO to solve the linear system of equations efficiently. The inversion algorithm is based on Gauss-Newton method, which has the efficient convergence rate. The Jacobian matrix is calculated by “adjoint forward modelling” efficiently. The synthetic inversion examples indicated that our proposed method is correct and effective. Furthermore, ignoring the topography effect can lead to incorrect results and interpretations.

  5. More-than-Moore 2.5D and 3D SiP integration

    CERN Document Server

    Radojcic, Riko

    2017-01-01

    This book presents a realistic and a holistic review of the microelectronic and semiconductor technology options in the post Moore’s Law regime. Technical tradeoffs, from architecture down to manufacturing processes, associated with the 2.5D and 3D integration technologies, as well as the business and product management considerations encountered when faced by disruptive technology options, are presented. Coverage includes a discussion of Integrated Device Manufacturer (IDM) vs Fabless, vs Foundry, and Outsourced Assembly and Test (OSAT) barriers to implementation of disruptive technology options. This book is a must-read for any IC product team that is considering getting off the Moore’s Law track, and leveraging some of the More-than-Moore technology options for their next microelectronic product. .

  6. Quintessence background for 5D Einstein-Gauss-Bonnet black holes

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, Sushant G. [University of KwaZulu-Natal, Astrophysics and Cosmology Research Unit, School of Mathematics, Statistics and Computer Science, Durban (South Africa); Centre for Theoretical Physics, New Delhi (India); Amir, Muhammed [Centre for Theoretical Physics, New Delhi (India); Maharaj, Sunil D. [University of KwaZulu-Natal, Astrophysics and Cosmology Research Unit, School of Mathematics, Statistics and Computer Science, Durban (South Africa)

    2017-08-15

    As we know that the Lovelock theory is an extension of the general relativity to the higher-dimensions, in this theory the first- and the second-order terms correspond to general relativity and the Einstein-Gauss-Bonnet gravity, respectively. We obtain a 5D black hole solution in Einstein-Gauss-Bonnet gravity surrounded by the quintessence matter, and we also analyze their thermodynamical properties. Owing to the quintessence corrected black hole, the thermodynamic quantities have also been corrected except for the black hole entropy, and a phase transition is achievable. The phase transition for the thermodynamic stability is characterized by a discontinuity in the specific heat at r = r{sub C}, with the stable (unstable) branch for r < (>) r{sub C}. (orig.)

  7. Adsorption of 3d, 4d, and 5d transition metal atoms on β 12-Borophene.

    Science.gov (United States)

    Alvarez-Quiceno, J C; Schleder, G R; Marinho, E; Fazzio, A

    2017-08-02

    We perform an ab initio study of the electronic structure and magnetic properties of 3d, 4d and 5d transition metals (TM) adsorbed on freestanding and Ag(1 1 1)-supported [Formula: see text]-borophene. The stability of TM adsorption is high for all atoms and increases with the period. For the 3d TM adsorption we observed strong exchange effects. The Ag(1 1 1)-surface induced small effects on the calculated properties. Studying the magnetic interaction between TMs, VIB atoms showed direct exchange, while VIIB and Fe showed 2p(B)-mediated indirect exchange. In the ultimate case of a one-dimensional TM array, Ru and Os also show direct exchange effects.

  8. Flap Gap Oscillatory Blowing on 2D and 2.5D Wing

    Directory of Open Access Journals (Sweden)

    Cătălin NAE

    2009-12-01

    Full Text Available Here we present preliminary results obtained in developing an active flow control system for highlift systems at advanced TRL level. The work is based on theoretical and experimental workperformed in AVERT EU FP6 project where the oscillatory flap gap blowing system was designedand tested on a INCAS F15 2D wing model. Pressure data and global loads have been recorded fora complex evaluation of the basic flow control mechanism. In 2.5D test cases this work has beenextended so that the proposed system may be selected as a mature technology in the JTI Clean Sky,Smart Fixed Wing Aircraft ITD. For this goal, new experimental setup was used and also updatedelectronics for the blowing system have been introduces. This was complemented by a newextension for the data acquisition system and visualization tools. Finally global correlations forbasic lift increments have been compared with the reference 2D case and analysed with respect tothe system efficiency.

  9. 5D optics for atomic clocks and gravito-inertial sensors

    Science.gov (United States)

    Bordé, Ch. J.

    2008-10-01

    A new framework is proposed to compare and unify photon and atomoptics, which rests on the quantization of proper time. A common waveequation written in five dimensions reduces both cases to 5D-optics ofmassless particles. The ordinary methods of optics (eikonal equation, Kirchhoff integral, Lagrange invariant, Fermat principle, symplectic algebraand ABCD matrices,...) are used to solve this equation in practical cases.The various phase shift cancellations, which occur in atom interferometers, and the quantum Langevin twin paradox for atoms, are then easily explained.A general phase-shift formula for interferometers is derived in fivedimensions, which applies to clocks as well as to gravito-inertial sensors.The application of this formula is illustrated in the case of atomicfountain clocks.

  10. Hints of 5d fixed point theories from non-Abelian T-duality

    Energy Technology Data Exchange (ETDEWEB)

    Lozano, Yolanda; Colgáin, Eoin Ó; Rodríguez-Gómez, Diego [Department of Physics, University of Oviedo,Avda. Calvo Sotelo 18, 33007 Oviedo (Spain)

    2014-05-05

    In this paper we investigate the properties of the putative 5d fixed point theory that should be dual, through the holographic correspondence, to the new supersymmetric AdS{sub 6} solution constructed in http://dx.doi.org/10.1103/PhysRevLett.110.231601. This solution is the result of a non-Abelian T-duality transformation on the known supersymmetric AdS{sub 6} solution of massive Type IIA. The analysis of the charge quantization conditions seems to put constraints on the global properties of the background, which, combined with the information extracted from considering probe branes, suggests a 2-node quiver candidate for the dual CFT.

  11. Instant outdoor localization and SLAM initialization from 2.5D maps.

    Science.gov (United States)

    Arth, Clemens; Pirchheim, Christian; Ventura, Jonathan; Schmalstieg, Dieter; Lepetit, Vincent

    2015-11-01

    We present a method for large-scale geo-localization and global tracking of mobile devices in urban outdoor environments. In contrast to existing methods, we instantaneously initialize and globally register a SLAM map by localizing the first keyframe with respect to widely available untextured 2.5D maps. Given a single image frame and a coarse sensor pose prior, our localization method estimates the absolute camera orientation from straight line segments and the translation by aligning the city map model with a semantic segmentation of the image. We use the resulting 6DOF pose, together with information inferred from the city map model, to reliably initialize and extend a 3D SLAM map in a global coordinate system, applying a model-supported SLAM mapping approach. We show the robustness and accuracy of our localization approach on a challenging dataset, and demonstrate unconstrained global SLAM mapping and tracking of arbitrary camera motion on several sequences.

  12. 2.5D Finite/infinite Element Approach for Simulating Train-Induced Ground Vibrations

    Science.gov (United States)

    Yang, Y. B.; Hung, H. H.; Kao, J. C.

    2010-05-01

    The 2.5D finite/infinite element approach for simulating the ground vibrations by surface or underground moving trains will be briefly summarized in this paper. By assuming the soils to be uniform along the direction of the railway, only a two-dimensional profile of the soil perpendicular to the railway need be considered in the modeling. Besides the two in-plane degrees of freedom (DOFs) per node conventionally used for plane strain elements, an extra DOF is introduced to account for the out-of-plane wave transmission. The profile of the half-space is divided into a near field and a semi-infinite far field. The near field containing the train loads and irregular structures is simulated by the finite elements, while the far field covering the soils with infinite boundary by the infinite elements, by which due account is taken of the radiation effects for the moving loads. Enhanced by the automated mesh expansion procedure proposed previously by the writers, the far field impedances for all the lower frequencies are generated repetitively from the mesh created for the highest frequency considered. Finally, incorporated with a proposed load generation mechanism that takes the rail irregularity and dynamic properties of trains into account, an illustrative case study was performed. This paper investigates the vibration isolation effect of the elastic foundation that separates the concrete slab track from the underlying soil or tunnel structure. In addition, the advantage of the 2.5D approach was clearly demonstrated in that the three-dimensional wave propagation effect can be virtually captured using a two-dimensional finite/infinite element mesh. Compared with the conventional 3D approach, the present approach appears to be simple, efficient and generally accurate.

  13. 5D imaging approaches reveal the formation of distinct intracellular cAMP spatial gradients

    Science.gov (United States)

    Rich, Thomas C.; Annamdevula, Naga; Trinh, Kenny; Britain, Andrea L.; Mayes, Samuel A.; Griswold, John R.; Deal, Joshua; Hoffman, Chase; West, Savannah; Leavesley, Silas J.

    2017-02-01

    Cyclic AMP (cAMP) is a ubiquitous second messenger known to differentially regulate many cellular functions. Several lines of evidence suggest that the distribution of cAMP within cells is not uniform. However, to date, no studies have measured the kinetics of 3D cAMP distributions within cells. This is largely due to the low signal-tonoise ratio of FRET-based probes. We previously reported that hyperspectral imaging improves the signal-to-noise ratio of FRET measurements. Here we utilized hyperspectral imaging approaches to measure FRET signals in five dimensions (5D) - three spatial (x, y, z), wavelength (λ), and time (t) - allowing us to visualize cAMP gradients in pulmonary endothelial cells. cAMP levels were measured using a FRET-based sensor (H188) comprised of a cAMP binding domain sandwiched between FRET donor and acceptor - Turquoise and Venus fluorescent proteins. We observed cAMP gradients in response to 0.1 or 1 μM isoproterenol, 0.1 or 1 μM PGE1, or 50 μM forskolin. Forskolin- and isoproterenol-induced cAMP gradients formed from the apical (high cAMP) to basolateral (low cAMP) face of cells. In contrast, PGE1-induced cAMP gradients originated from both the basolateral and apical faces of cells. Data suggest that 2D (x,y) studies of cAMP compartmentalization may lead to erroneous conclusions about the existence of cAMP gradients, and that 3D (x,y,z) studies are required to assess mechanisms of signaling specificity. Results demonstrate that 5D imaging technologies are powerful tools for measuring biochemical processes in discrete subcellular domains.

  14. Telomerase activity in patients with stage 2-5D chronic kidney disease.

    Science.gov (United States)

    Kidir, Veysel; Aynali, Ayse; Altuntas, Atila; Inal, Salih; Aridogan, Buket; Sezer, Mehmet Tugrul

    Molecular mechanisms of increased cardiovascular mortality in chronic kidney disease (CKD) associated with biological age are not well understood. Recent studies support the hypothesis that common factors responsible for this phenomenon are cellular aging and telomere dysfunction. The purpose of this study was to investigate the relation between telomerase activity and CKD stages. The study included 120 patients who were followed-up for CKD stage 2-5D, composed of 30 patients of each stage and 30 healthy volunteers without any known disease who were admitted to our hospital for routine check-ups. Telomerase activity in peripheral blood mononuclear cells (PBMC) was measured using the TRAP assay. A significant difference was observed for telomerase activity in PBMC between groups. The detected levels were lowest in the healthy control group (0.15±0.02), and highest in CKD stage 5D patients (0.23±0.04). In CKD patients, telomerase activity in PBMC was positively correlated with the CKD stage, serum creatinine, potassium and parathormone levels, and negatively correlated with estimated glomerular filtration rate (eGFR), body mass index (BMI), platelet count and serum calcium levels. According to the linear regression analysis, independent predictors for high telomerase activity in CKD patients were eGFR and BMI. Telomerase activity in PBMC increases with advancing CKD stage in CKD patients. Increased telomerase activity in PBMC is associated with eGFR and BMI. Copyright © 2017 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.

  15. Reliability, validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with social phobia

    Science.gov (United States)

    2013-01-01

    Objective The aim of the study was to analyse the psychometric properties of the EQ-5D in patients with social phobia. Methods We used a sample of 445 patients with social phobia with five measurement points over a 30 month period. The discriminative ability of the EQ-5D was analysed by comparing the patients’ responses with the general population and between different disease severity levels. For test-retest reliability we assessed the level of agreement in patients’ responses over time, when there was no change in the Liebowitz Social Anxiety Scale (LSAS). Construct validity was analysed by identifying correlations of the EQ-5D with more specific instruments. For responsiveness we compared the means of EQ VAS/EQ-5D index anchored on improved (deteriorated) health status and computed effect sizes as well as a receiver operating characteristic (ROC) curve. Results Compared to the general population, patients with social phobia reported more problems in the dimensions “usual activities”, “pain/discomfort”, and “anxiety/depression” and less problems in “mobility” and “self-care”. The EQ-5D was able to distinguish between different disease severity levels. The test-retest reliability was moderate (intraclass correlation coefficient > 0.6). Correlations between the EQ-5D and other instruments were mostly small except for correlations with Beck Depression Inventory. The EQ-5D index seemed to be more responsive than the EQ VAS, but with only medium effect sizes (0.5 < effect size < 0.8) in the British EQ-5D index and only significant in patients with improved health status. The ROC analysis revealed no significant results. Conclusions The EQ-5D was moderately reliable and responsive in patients with improved health status. Construct validity was limited. Trial registration Current controlled trials ISRCTN53517394 PMID:24365384

  16. Induced Matter Theory of gravity from a Weitzenboeck 5D vacuum and pre-big bang collapse of the universe

    Energy Technology Data Exchange (ETDEWEB)

    Romero, Jesus Martin [Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Instituto de Investigaciones Fisicas de Mar del Plata (IFIMAR), Mar del Plata (Argentina); Bellini, Mauricio [Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Instituto de Investigaciones Fisicas de Mar del Plata (IFIMAR), Mar del Plata (Argentina); Universidad Nacional de Mar del Plata, Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Funes 3350, C.P. 7600, Mar del Plata (Argentina)

    2013-02-15

    We extend the Induced Matter Theory of gravity (IMT) to 5D curved spacetimes by using the Weitzenboeck representation of connections on a 5D curved spacetime. In this representation the 5D curvature tensor becomes null, so that we can make a static foliation on the extra non-compact coordinate to induce in the Weitzenboeck representation the Einstein equations. Once we have done it, we can rewrite the effective 4D Einstein equations in the Levi-Civita representation. This generalization of IMT opens a huge window of possible applications for this theory. A pre-big bang collapsing scenario is explored as an example. (orig.)

  17. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D

    DEFF Research Database (Denmark)

    Bräuner-Osborne, H; Jensen, A A; Sheppard, P O

    2001-01-01

    predicted to encode an additional subtype. The full length coding regions of mouse mGprc5d and human GPRC5D were cloned and shown to contain predicted open reading frames of 300 and 345 amino acids, respectively. GPRC5D has seven putative transmembrane segments and is expressed in the cell membrane....... The four human receptor subtypes, which we assign to group 5 of family C GPCRs, show 31-42% amino acid sequence identity to each other and 20-25% sequence identity to the transmembrane domains of metabotropic glutamate receptor subtypes 2 and 3 and other family C members. In contrast to the remaining...

  18. Exome sequencing identifies a novel UNC5D mutation in a severe myopic anisometropia family: A case report.

    Science.gov (United States)

    Feng, Lei; Zhou, Daizhan; Zhang, Zhou; He, Lin; Liu, Yun; Yang, Yabo

    2017-06-01

    Severe myopic anisometropia has been identified to have heritability, but the pathogenesis of anisometropia still remains obscure. Here, we presented a Chinese severe myopic anisometropia family with 5 members affected. Though using the exome sequencing, we identified a novel mutation in the UNC5D gene (c.1297C>T, p.R433C), which was predicted to have a damage effect on the protein function and kept highly conserved throughout evolution across species. As previously described, the UNC5D gene belongs to the UNC5 protein family and may have functions to regulate neuronal migration, axon guidance, and cell survival. The expression of UNC5D was also co-located at the visual areas of the mouse cortical regions at early postnatal ages. Our data provide the first evidence for involvement of UNC5D gene in the severe myopic anisometropia.

  19. Reliability and validity of the EQ-5D-3L for Kashin-Beck disease in China.

    Science.gov (United States)

    Fang, Hua; Farooq, Umer; Wang, Dimiao; Yu, Fangfang; Younus, Mohammad Imran; Guo, Xiong

    2016-01-01

    Kashin-Beck Disease (KBD) is an endemic osteoarthropathy in areas which extend from the North-East to the South-West of China. Most of the patients with KBD suffer multiple dysfunctions in major joints causing decreased health status. However because of their low education level and unique living habits, it is hard to find tools to measure the health-related quality of life (HRQOL). European quality of life (EQ-5D-3L) patient-reported instrument is widely used to measure HRQOL. This study aimed to establish the validity and reliability of the Chinese version of the EQ-5D-3L for evaluating HRQOL of KBD individuals in rural area. 368 individuals who were suffering from KBD were recruited through stratified multistage random sampling from Shaanxi province, China. The EQ-5D-3L and the WHOQOL-BREF were administrated in each individual by face to face interview. Test-retest reliability was assessed at 10-14 days intervals. The test-retest reliability was measured by calculating the Kappa coefficients for EQ-5D-3L five dimensions. For the EQ VAS, the intraclass correlation coefficient (ICC) was computed. Convergent and divergent analysis, construct validity was established using Spearman's rank correlation between the EQ-5D-3L and the WHOQOL-BREF. Known groups' validity was examined by comparing groups with a priori expected differences in health-related quality of life (HRQOL). For 362 individuals (98%), comprehensive data of all the EQ-5D-3L dimensions were available. Kappa values of the EQ-5D-3L five items ranged from 0.324 to 0.554. ICC of the EQ VAS was 0.497. For convergent validity, the three items (self-care, usual activity, and mobility) of EQ-5D-3L, index scores, and VAS showed moderate correlations with the physical health domain of the WHOQOL-BREF (r absolute value ranged from 0.339 to 0.475). For divergent validity, the 5 items of EQ-5D-3L showed weak or no correlations with environment and social relationship domains of WHOQOL-BREF. The Chinese EQ-5D-3L

  20. Converting the SF-12 into the EQ-5D: an empirical comparison of methodologies.

    Science.gov (United States)

    Chuang, Ling-Hsiang; Kind, Paul

    2009-01-01

    For cost-utility analysis, analysts need a measure that summarizes health-status utilities in a single index of health-related quality of life (HR-QOL). It is common to find in clinical studies that only an HR-QOL profile measure such as the SF-36 is included, but not the summary HR-QOL index. Therefore, the economist's usual practice is to reprocess the profile data into a single index format. Several 'after-market' tools are available to convert the SF-36 or SF-12 into a single form with or without utility-weighting metric property. However, there has been no consensus with regard to a regression method that should be recommended for such a mapping task. To report on the performance of different regression methods that have previously been applied to the conversion of SF-12 data in the analysis of a single common dataset. The mapping between the SF-12 and EQ-5D is the focus. The data were adopted from the Medical Expenditure Panel Survey 2003 where 19 678 adults completed both EQ-5D and SF-12 questionnaires. Four econometric techniques, namely ordinary least squares (OLS), censored least absolute deviation, multinomial logit model and two-part model regressions were investigated together with two main types of model specifications: item-based and summary score-based. The performance of each examined model was judged by various criteria, including its estimated mean, the size of mean absolute error and the number of errors. Among four compared econometric techniques, OLS regression was the most accurate model in estimating the group mean. Models with item-based model specification performed better than those with summary score-based regardless of the chosen econometric technique. Nevertheless, the accuracy of OLS deteriorates in older and less healthy subgroups. The results also suggested that the two-part model, which addresses the heterogeneity issue, performs better in these vulnerable subgroups. None of the mapping methods included in the current study are

  1. Translation, validity and reliability of the British Sign Language (BSL) version of the EQ-5D-5L.

    Science.gov (United States)

    Rogers, Katherine D; Pilling, Mark; Davies, Linda; Belk, Rachel; Nassimi-Green, Catherine; Young, Alys

    2016-07-01

    To translate the health questionnaire EuroQol EQ-5D-5L into British Sign Language (BSL), to test its reliability with the signing Deaf population of BSL users in the UK and to validate its psychometric properties. The EQ-5D-5L BSL was developed following the international standard for translation required by EuroQol, with additional agreed features appropriate to a visual language. Data collection used an online platform to view the signed (BSL) version of the tests. The psychometric testing included content validity, assessed by interviewing a small sample of Deaf people. Reliability was tested by internal consistency of the items and test-retest, and convergent validity was assessed by determining how well EQ-5D-5L BSL correlates with CORE-10 BSL and CORE-6D BSL. The psychometric properties of the EQ-5D-5L BSL are good, indicating that it can be used to measure health status in the Deaf signing population in the UK. Convergent validity between EQ-5D-5L BSL and CORE-10 BSL and CORE-6D BSL is consistent, demonstrating that the BSL version of EQ-5D-5L is a good measure of the health status of an individual. The test-retest reliability of EQ-5D-5L BSL, for each dimension of health, was shown to have Cohen's kappa values of 0.47-0.61; these were in the range of moderate to good and were therefore acceptable. This is the first time EQ-5D-5L has been translated into a signed language for use with Deaf people and is a significant step forward towards conducting studies of health status and cost-effectiveness in this population.

  2. F5D-1 on ramp with Neil Armstrong preparing to fly a Dyna-Soar simulation

    Science.gov (United States)

    1962-01-01

    The Douglas F5D-1 Skylancer being pre-flighted by the pilot while the crew chief prepares to pull the wheel chocks on the 'hot gun' ramp at Edwards Air Force Base, California. The aircraft was one of two prototype F5D-1s obtained by NASA Flight Research Center in 1961. The F5D-1 Skylancer (Bu. No. 142350) had a red and white paint pattern with a NASA identification number of 213 which later became NASA 708. The Douglas F5D-1 Skylancer was built by the Navy as an all-weather fighter interceptor that never made the jump to production. Four test aircraft were developed with the same basic airframe as the Douglas F4D Skyray. With increasing modifications the four aircraft were re-designated F5D-1s before their first flights. Future Astronaut Neil Armstrong was one of the NASA research pilots assigned to support duties for the Dyna-Soar program. In addition to working at the Boeing facility in Washington state, Armstrong also tested the Dyna-Soar launch abort profile using this F5D-1, which had a similar wing shape to the Dyna-Soar. The aircraft arrived at the Flight Research Center on June 15, 1961. After the Dyna-Soar program was cancelled in December 1963, this F5D-1 continued to be used, serving as a flying simulator for the M2-F2 and as a chase plane for lifting-body flights (providing the lifting-body pilot with an extra set of eyes to assist in emergencies and avert potential crashes) This F5D-1 left the Flight Research Center (later designated the Dryden Flight Research Center) on May 19, 1970, and was donated to the Neil A. Armstrong Museum in Wapakoneta, Ohio.

  3. The benefits of, and barriers to, implementation of 5D BIM for quantity surveying in New Zealand

    OpenAIRE

    Ryan Stanley; Derek Pierre Thurnell

    2014-01-01

    Building Information Modelling (BIM) models are relational and parametric in nature, and 5D BIM is where model objects include specification data and other properties which can be directly used for pricing construction work. There is huge potential for its use by quantity surveyors (QSs) for such tasks as quantity take-offs, estimation and cost management, in a collaborative project environment. Perceptions regarding the benefits of, and barriers to, the implementation of 5D BIM by quantity s...

  4. Quality of life profile and psychometric properties of the EQ-5D-5L in HIV/AIDS patients.

    Science.gov (United States)

    Tran, Bach Xuan; Ohinmaa, Arto; Nguyen, Long Thanh

    2012-11-01

    We assessed health-related quality of life (HRQOL), its associated factors, and examined measurement properties of the EuroQol - 5 Dimensions - 5 Levels (EQ-5D-5L) in HIV/AIDS patients. A cross-sectional multi-site survey was conducted in 1016 patients (age: 35.4 ± 7.0 years; 63.8% male) in three epicenters of Vietnam. Internal consistency reliability, convergent validity, and discriminative validity of the EQ-5D-5L and a visual analogue scale (VAS) were evaluated. Tobit censored regression models were used to identify predictors of HRQOL in HIV/AIDS patients. The mean EQ-5D-5L single index and VAS were 0.65 (95% Confidence Interval (CI) = 0.63; 0.67) and 70.3 (95% CI = 69.2; 71.5). Cronbach's alpha of five dimensions was 0.85. EQ-5D-5L has a good convergent validity with VAS (0.73). It discriminated patients at different HIV/AIDS stages, duration of ART, and CD4 cell count. Predictors of poorer HRQOL included being female, lower education level, unemployment, alcohol and drug use, CD4AIDS stages. The EQ-5D-5L has good measurement properties in HIV/AIDS patients and holds potentials for monitoring ART outcomes. Integration of HRQOL measurement using EQ-5D-5L in HIV/AIDS clinical practice could be helpful for economic evaluation of HIV/AIDS interventions.

  5. Effects of low-level deuterium enrichment on bacterial growth.

    Directory of Open Access Journals (Sweden)

    Xueshu Xie

    Full Text Available Using very precise (±0.05% measurements of the growth parameters for bacteria E. coli grown on minimal media, we aimed to determine the lowest deuterium concentration at which the adverse effects that are prominent at higher enrichments start to become noticeable. Such a threshold was found at 0.5% D, a surprisingly high value, while the ultralow deuterium concentrations (≤0.25% D showed signs of the opposite trend. Bacterial adaptation for 400 generations in isotopically different environment confirmed preference for ultralow (≤0.25% D enrichment. This effect appears to be similar to those described in sporadic but multiple earlier reports. Possible explanations include hormesis and isotopic resonance phenomena, with the latter explanation being favored.

  6. Effects of low-level deuterium enrichment on bacterial growth.

    Science.gov (United States)

    Xie, Xueshu; Zubarev, Roman A

    2014-01-01

    Using very precise (±0.05%) measurements of the growth parameters for bacteria E. coli grown on minimal media, we aimed to determine the lowest deuterium concentration at which the adverse effects that are prominent at higher enrichments start to become noticeable. Such a threshold was found at 0.5% D, a surprisingly high value, while the ultralow deuterium concentrations (≤0.25% D) showed signs of the opposite trend. Bacterial adaptation for 400 generations in isotopically different environment confirmed preference for ultralow (≤0.25% D) enrichment. This effect appears to be similar to those described in sporadic but multiple earlier reports. Possible explanations include hormesis and isotopic resonance phenomena, with the latter explanation being favored.

  7. Thermal breeder fuel enrichment zoning

    Science.gov (United States)

    Capossela, Harry J.; Dwyer, Joseph R.; Luce, Robert G.; McCoy, Daniel F.; Merriman, Floyd C.

    1992-01-01

    A method and apparatus for improving the performance of a thermal breeder reactor having regions of higher than average moderator concentration are disclosed. The fuel modules of the reactor core contain at least two different types of fuel elements, a high enrichment fuel element and a low enrichment fuel element. The two types of fuel elements are arranged in the fuel module with the low enrichment fuel elements located between the high moderator regions and the high enrichment fuel elements. Preferably, shim rods made of a fertile material are provided in selective regions for controlling the reactivity of the reactor by movement of the shim rods into and out of the reactor core. The moderation of neutrons adjacent the high enrichment fuel elements is preferably minimized as by reducing the spacing of the high enrichment fuel elements and/or using a moderator having a reduced moderating effect.

  8. Efficient parallel implementations of approximation algorithms for guarding 1.5D terrains

    Directory of Open Access Journals (Sweden)

    Goran Martinović

    2015-03-01

    Full Text Available In the 1.5D terrain guarding problem, an x-monotone polygonal line is dened by k vertices and a G set of terrain points, i.e. guards, and a N set of terrain points which guards are to observe (guard. This involves a weighted version of the guarding problem where guards G have weights. The goal is to determine a minimum weight subset of G to cover all the points in N, including a version where points from N have demands. Furthermore, another goal is to determine the smallest subset of G, such that every point in N is observed by the required number of guards. Both problems are NP-hard and have a factor 5 approximation [3, 4]. This paper will show that if the (1+ϵ-approximate solver for the corresponding linear program is a computer, for any ϵ > 0, an extra 1+ϵ factor will appear in the final approximation factor for both problems. A comparison will be carried out the parallel implementation based on GPU and CPU threads with the Gurobi solver, leading to the conclusion that the respective algorithm outperforms the Gurobi solver on large and dense inputs typically by one order of magnitude.

  9. Gravitational waves during inflation from a 5D large-scale repulsive gravity model

    Energy Technology Data Exchange (ETDEWEB)

    Reyes, Luz M., E-mail: luzmarinareyes@gmail.com [Departamento de Matematicas, Centro Universitario de Ciencias Exactas e ingenierias (CUCEI), Universidad de Guadalajara (UdG), Av. Revolucion 1500, S.R. 44430, Guadalajara, Jalisco (Mexico); Moreno, Claudia, E-mail: claudia.moreno@cucei.udg.mx [Departamento de Matematicas, Centro Universitario de Ciencias Exactas e ingenierias (CUCEI), Universidad de Guadalajara (UdG), Av. Revolucion 1500, S.R. 44430, Guadalajara, Jalisco (Mexico); Madriz Aguilar, Jose Edgar, E-mail: edgar.madriz@red.cucei.udg.mx [Departamento de Matematicas, Centro Universitario de Ciencias Exactas e ingenierias (CUCEI), Universidad de Guadalajara (UdG), Av. Revolucion 1500, S.R. 44430, Guadalajara, Jalisco (Mexico); Bellini, Mauricio, E-mail: mbellini@mdp.edu.ar [Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, C.P. 7600, Mar del Plata (Argentina); Instituto de Investigaciones Fisicas de Mar del Plata (IFIMAR) - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) (Argentina)

    2012-10-22

    We investigate, in the transverse traceless (TT) gauge, the generation of the relic background of gravitational waves, generated during the early inflationary stage, on the framework of a large-scale repulsive gravity model. We calculate the spectrum of the tensor metric fluctuations of an effective 4D Schwarzschild-de Sitter metric on cosmological scales. This metric is obtained after implementing a planar coordinate transformation on a 5D Ricci-flat metric solution, in the context of a non-compact Kaluza-Klein theory of gravity. We found that the spectrum is nearly scale invariant under certain conditions. One interesting aspect of this model is that it is possible to derive the dynamical field equations for the tensor metric fluctuations, valid not just at cosmological scales, but also at astrophysical scales, from the same theoretical model. The astrophysical and cosmological scales are determined by the gravity-antigravity radius, which is a natural length scale of the model, that indicates when gravity becomes repulsive in nature.

  10. Telomerase activity in patients with stage 2–5D chronic kidney disease

    Directory of Open Access Journals (Sweden)

    Veysel Kidir

    2017-11-01

    Full Text Available Background: Molecular mechanisms of increased cardiovascular mortality in chronic kidney disease (CKD associated with biological age are not well understood. Recent studies support the hypothesis that common factors responsible for this phenomenon are cellular aging and telomere dysfunction. Objectives: The purpose of this study was to investigate the relation between telomerase activity and CKD stages. Methods: The study included 120 patients who were followed-up for CKD stage 2–5D, composed of 30 patients of each stage and 30 healthy volunteers without any known disease who were admitted to our hospital for routine check-ups. Telomerase activity in peripheral blood mononuclear cells (PBMC was measured using the TRAP assay. Results: A significant difference was observed for telomerase activity in PBMC between groups. The detected levels were lowest in the healthy control group (0.15 ± 0.02, and highest in CKD stage 5D patients (0.23 ± 0.04. In CKD patients, telomerase activity in PBMC was positively correlated with the CKD stage, serum creatinine, potassium and parathormone levels, and negatively correlated with estimated glomerular filtration rate (eGFR, body mass index (BMI, platelet count and serum calcium levels. According to the linear regression analysis, independent predictors for high telomerase activity in CKD patients were eGFR and BMI. Conclusion: Telomerase activity in PBMC increases with advancing CKD stage in CKD patients. Increased telomerase activity in PBMC is associated with eGFR and BMI. Resumen: Antecedentes: Los mecanismos moleculares responsables del aumento de la mortalidad cardiovascular en la enfermedad renal crónica (ERC asociada a la edad biológica no se conocen bien. Los estudios recientes apoyan la hipótesis de que los factores comunes responsables de este fenómeno son el envejecimiento celular y la disfunción telomérica. Objetivos: El objetivo de este estudio fue investigar

  11. The development of vector based 2.5D print methods for a painting machine

    Science.gov (United States)

    Parraman, Carinna

    2013-02-01

    Through recent trends in the application of digitally printed decorative finishes to products, CAD, 3D additive layer manufacturing and research in material perception, [1, 2] there is a growing interest in the accurate rendering of materials and tangible displays. Although current advances in colour management and inkjet printing has meant that users can take for granted high-quality colour and resolution in their printed images, digital methods for transferring a photographic coloured image from screen to paper is constrained by pixel count, file size, colorimetric conversion between colour spaces and the gamut limits of input and output devices. This paper considers new approaches to applying alternative colour palettes by using a vector-based approach through the application of paint mixtures, towards what could be described as a 2.5D printing method. The objective is to not apply an image to a textured surface, but where texture and colour are integral to the mark, that like a brush, delineates the contours in the image. The paper describes the difference between the way inks and paints are mixed and applied. When transcribing the fluid appearance of a brush stroke, there is a difference between a halftone printed mark and a painted mark. The issue of surface quality is significant to subjective qualities when studying the appearance of ink or paint on paper. The paper provides examples of a range of vector marks that are then transcribed into brush stokes by the painting machine.

  12. Pressure-induced crossing of the core levels in 5 d metals

    Science.gov (United States)

    Tal, Alexey A.; Katsnelson, Mikhail I.; Ekholm, Marcus; Jönsson, H. Johan M.; Dubrovinsky, Leonid; Dubrovinskaia, Natalia; Abrikosov, Igor A.

    2016-05-01

    A pressure-induced interaction between core electrons, the core-level crossing (CLC) transition, has been observed in hcp Os at P ≈400 GPa [L. Dubrovinsky et al., Nature (London) 525, 226 (2015)], 10.1038/nature14681. By carrying out a systematic theoretical study for all metals of the 5 d series (Hf, Ta, W, Re, Os, Ir, Pt, Au) we have found that the CLC transition is a general effect for this series of metals. While in Pt it occurs at ≈1500 GPa , at a pressure substantially higher than in Os, in Ir it occurs already at 80 GPa. Moreover, we predict that in Re the CLC transition may take place already at ambient pressure. We explain the effect of the CLC and analyze the shift of the transition pressure across the series within the Thomas-Fermi model. In particular, we show that the effect has many common features with the atomic collapse in rare-earth elements.

  13. Hypercrater Bifurcations, Attractor Coexistence, and Unfolding in a 5D Model of Economic Dynamics

    Directory of Open Access Journals (Sweden)

    Toichiro Asada

    2011-01-01

    Full Text Available Complex dynamical features are explored in a discrete interregional macrodynamic model proposed by Asada et al., using numerical methods. The model is five-dimensional with four parameters. The results demonstrate patterns of dynamical behaviour, such as bifurcation processes and coexistence of attractors, generated by high-dimensional discrete systems. In three cases of two-dimensional parameter subspaces the stability of equilibrium region is determined and its boundaries, the flip and Neimark-Hopf bifurcation curves, are identified by means of necessary coefficient criteria. In the first case closed invariant curves (CICs are found to occur through 5D-crater-type bifurcations, and for certain ranges of parameter values a stable equilibrium coexists with an unstable CIC associated with the subcritical bifurcation, as well as with an outer stable CIC. A remarkable feature of the second case is the coexistence of two attracting CICs outside the stability region. In both these cases the related hysteresis effects are illustrated by numerical simulations. In the third case a remarkable feature is the apparent unfolding of an attracting CIC before it evolves to a chaotic attractor. Examples of CICs and chaotic attractors are given in subspaces of phase space.

  14. Pressure-induced core-level crossing transitions in 5d metals.

    Science.gov (United States)

    Abrikosov, Igor

    Considering hexagonal closed-packed Os compressed to over 770 GPa, we discuss the anomaly observed experimentally in the behavior of the unit cells parameters ratio c/a at about 440 GPa. We argue that the anomaly is related to a new type of electronic transition, the core level crossing (CLC) transition, associated with interactions between the core electrons induced by pressure. By carrying out a systematic theoretical study for all metals of the 5d series (Hf, Ta, W, Re, Os, Ir, Pt, Au) we have found that the CLC transition is a general effect for this series of metals. While in Pt it occurs at 1500 GPa, at a pressure substantially higher than in Os, in Ir it occurs already at 80 GPa. Moreover, we predict that in Re the CLC transition may take place already at ambient pressure. We explain the effect of the CLC and analyze the shift of the transition pressure across the series within the Thomas-Fermi model. In particular, we show that the effect has many common features with the atomic collapse in rare-earth elements. The Swedish Research Council (VR) Grant No. 2015-04391 and the Grant from the Ministry of Education and Science of the Russian Federation (Grant No. 14.Y26.31.0005) are gratefully acknowledged.

  15. Frequency-domain Green's functions for radar waves in heterogeneous 2.5D media

    Science.gov (United States)

    Ellefsen, K.J.; Croize, D.; Mazzella, A.T.; McKenna, J.R.

    2009-01-01

    Green's functions for radar waves propagating in heterogeneous 2.5D media might be calculated in the frequency domain using a hybrid method. The model is defined in the Cartesian coordinate system, and its electromagnetic properties might vary in the x- and z-directions, but not in the y-direction. Wave propagation in the x- and z-directions is simulated with the finite-difference method, and wave propagation in the y-direction is simulated with an analytic function. The absorbing boundaries on the finite-difference grid are perfectly matched layers that have been modified to make them compatible with the hybrid method. The accuracy of these numerical Greens functions is assessed by comparing them with independently calculated Green's functions. For a homogeneous model, the magnitude errors range from -4.16% through 0.44%, and the phase errors range from -0.06% through 4.86%. For a layered model, the magnitude errors range from -2.60% through 2.06%, and the phase errors range from -0.49% through 2.73%. These numerical Green's functions might be used for forward modeling and full waveform inversion. ?? 2009 Society of Exploration Geophysicists. All rights reserved.

  16. Metamorphosis of the cosmological constant and 5D origin of the fiducial metric

    Science.gov (United States)

    Gabadadze, Gregory; Yu, Siqing

    2016-11-01

    In a recently proposed theory, the cosmological constant (CC) does not curve spacetime in our Universe, but instead gets absorbed into another universe endowed with its own dynamical metric, nonlocally coupled to ours. Thus, one achieves a long standing goal of removing entirely any cosmological constant from our Universe. Dark energy then cannot be due to a cosmological constant, but must be obtained via other mechanisms. Here we focus on the scenario in which dark energy is due to massive gravity and its extensions. We show how the metric of the other universe, that absorbs our CC, also gives rise to the fiducial metric known to be necessary for the diffeomorphism invariant formulation of massive gravity. This is achieved in a framework where the other universe is described by 5D AdS gravity, while our Universe lives on its boundary and is endowed with dynamical massive gravity. A nondynamical pullback of the bulk AdS metric acts as the fiducial metric for massive gravity on the boundary. This framework also removes a difficulty caused by the quantum strongly coupled behavior of massive gravity at the Λ3 scale: in the present approach, the massive gravity action does not receive any loop-induced counterterms, despite being strongly coupled.

  17. Evaluation of High Lift System with Oscillatory Blowing in 2.5D Configuration

    Directory of Open Access Journals (Sweden)

    Cǎtǎlin NAE

    2010-06-01

    Full Text Available Following the successful results of the test campaign on 2D configuration of the oscillatoryblowing system in the flap gap of the INCAS F15 wind tunnel model, extensive evaluation of the 2.5Deffects have been initiated in order to enable solid understanding of the fluidic integrationsmechanisms and to validate this technology at a higher TRL level. Initial experiments on 2Dconfiguration were based on work performed in AVERT EU FP6 project where the oscillatory flapgap blowing system was designed and tested on a INCAS F15 2D wing model. In 2.5D test cases thiswork has been extended so that the proposed system may be selected as a mature technology in theJTI Clean Sky, Smart Fixed Wing Aircraft ITD. New experimental setup was used and also updatedelectronics for the blowing system have been introduces. This was complemented by a new extensionfor the data acquisition system and visualization tools. Complex post-processing of the experimentaldata was mainly oriented towards system efficiency and TRL evaluation for this active technology.

  18. Gravitational waves during inflation from a 5D large-scale repulsive gravity model

    Science.gov (United States)

    Reyes, Luz M.; Moreno, Claudia; Madriz Aguilar, José Edgar; Bellini, Mauricio

    2012-10-01

    We investigate, in the transverse traceless (TT) gauge, the generation of the relic background of gravitational waves, generated during the early inflationary stage, on the framework of a large-scale repulsive gravity model. We calculate the spectrum of the tensor metric fluctuations of an effective 4D Schwarzschild-de Sitter metric on cosmological scales. This metric is obtained after implementing a planar coordinate transformation on a 5D Ricci-flat metric solution, in the context of a non-compact Kaluza-Klein theory of gravity. We found that the spectrum is nearly scale invariant under certain conditions. One interesting aspect of this model is that it is possible to derive the dynamical field equations for the tensor metric fluctuations, valid not just at cosmological scales, but also at astrophysical scales, from the same theoretical model. The astrophysical and cosmological scales are determined by the gravity-antigravity radius, which is a natural length scale of the model, that indicates when gravity becomes repulsive in nature.

  19. Coronary Revascularization in Patients with CKD Stage 5D: Pragmatic Considerations.

    Science.gov (United States)

    Shroff, Gautam R; Herzog, Charles A

    2016-12-01

    Coronary revascularization decisions for patients with CKD stage 5D present a dilemma for clinicians because of high baseline risks of mortality and future cardiovascular events. This population differs from the general population regarding characteristics of coronary plaque composition and behavior, accuracy of noninvasive testing, and response to surgical and percutaneous revascularization, such that findings from the general population cannot be automatically extrapolated. However, this high-risk population has been excluded from all randomized trials evaluating outcomes of revascularization. Observational studies have attempted to address long-term outcomes after surgical versus percutaneous revascularization strategies, but inherent selection bias may limit accuracy. Compared with percutaneous strategies, surgical revascularization seems to have long-term survival benefit on the basis of observational data but associates with substantially higher short-term mortality rates. Percutaneous revascularization with drug-eluting and bare metal stents associates with a high risk of in-stent restenosis and need for future revascularization, perhaps contributing to the higher long-term mortality hazard. Off-pump coronary bypass surgery and the newest generation of drug-eluting stent platforms offer no definitive benefits. In this review, we address the nuances, complexities, and tradeoffs that clinicians face in determining the optimal method of coronary revascularization for this high-risk population. Copyright © 2016 by the American Society of Nephrology.

  20. Econometric modelling of multiple self-reports of health states: The switch from EQ-5D-3L to EQ-5D-5L in evaluating drug therapies for rheumatoid arthritis.

    Science.gov (United States)

    Hernández-Alava, Mónica; Pudney, Stephen

    2017-09-01

    EQ-5D is used in cost-effectiveness studies underlying many important health policy decisions. It comprises a survey instrument describing health states across five domains, and a system of utility values for each state. The original 3-level version of EQ-5D is being replaced with a more sensitive 5-level version but the consequences of this change are uncertain. We develop a multi-equation ordinal response model incorporating a copula specification with normal mixture marginals to analyse joint responses to EQ-5D-3L and EQ-5D-5L in a survey of people with rheumatic disease, and use it to generate mappings between the alternative descriptive systems. We revisit a major cost-effectiveness study of drug therapies for rheumatoid arthritis, mapping the original EQ-5D-3L measure onto a 5L valuation basis. Working within a comprehensive, flexible econometric framework, we find that use of simpler restricted specifications can make very large changes to cost-effectiveness estimates with serious implications for decision-making. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  1. Comparison between EQ-5D and SF-6D utility in rural residents of Jiangsu Province, China.

    Science.gov (United States)

    Jin, Hui; Wang, Bei; Gao, Qian; Chao, Jianqian; Wang, Siyuan; Tian, Lin; Liu, Pei

    2012-01-01

    The SF-6D and EQ-5D are widely used generic index measures as health-related quality of life. We assessed within-subject agreement between SF-6D and EQ-5D utilities with different preference weights, and their validities in measuring Chinese rural residents, before and after standardization scores. Rural residents over 18 years old were interviewed using EQ-5D and SF-6D in Jiangsu Province, China. EQ-5D utility-scoring algorithms were used from three conversion tables from the United Kingdom, Japan, and the United States. Validities, Sensitivity and agreement between instruments were computed and compared. Factors affecting utility difference were explored with multiple liner regression models. Scores with standardization intervals of 0-1 in the two instruments were analyzed by the use of the above methods again. In 929 respondents, relative efficiency statistic and receiver operating characteristic curves analysis showed SF-6D to be the more efficient, followed by the EQ-5D model in Japan weights. Bland-Altman plot analysis showed paired SF-6D/EQ-5D in UK weights had better agreement. Though some risk factors were found, multiple liner regression demonstrated most coefficients were weaker than 0.2, and all R(2) values were less than 0.06. Standardization did not significantly influence these results except scores' value. SF-6D and next EQ-5D in Japan weights could be used for Chinese rural residents. Further research with larger sample size of population is needed to establish and determine the feasibility of standardization score.

  2. Comparison between EQ-5D and SF-6D utility in rural residents of Jiangsu Province, China.

    Directory of Open Access Journals (Sweden)

    Hui Jin

    Full Text Available BACKGROUND: The SF-6D and EQ-5D are widely used generic index measures as health-related quality of life. We assessed within-subject agreement between SF-6D and EQ-5D utilities with different preference weights, and their validities in measuring Chinese rural residents, before and after standardization scores. METHODOLOGY/PRINCIPAL FINDINGS: Rural residents over 18 years old were interviewed using EQ-5D and SF-6D in Jiangsu Province, China. EQ-5D utility-scoring algorithms were used from three conversion tables from the United Kingdom, Japan, and the United States. Validities, Sensitivity and agreement between instruments were computed and compared. Factors affecting utility difference were explored with multiple liner regression models. Scores with standardization intervals of 0-1 in the two instruments were analyzed by the use of the above methods again. In 929 respondents, relative efficiency statistic and receiver operating characteristic curves analysis showed SF-6D to be the more efficient, followed by the EQ-5D model in Japan weights. Bland-Altman plot analysis showed paired SF-6D/EQ-5D in UK weights had better agreement. Though some risk factors were found, multiple liner regression demonstrated most coefficients were weaker than 0.2, and all R(2 values were less than 0.06. Standardization did not significantly influence these results except scores' value. CONCLUSIONS/SIGNIFICANCE: SF-6D and next EQ-5D in Japan weights could be used for Chinese rural residents. Further research with larger sample size of population is needed to establish and determine the feasibility of standardization score.

  3. Mapping of the Insomnia Severity Index and other sleep measures to EuroQol EQ-5D health state utilities.

    Science.gov (United States)

    Gu, Ning Yan; Botteman, Marc F; Ji, Xiang; Bell, Christopher F; Carter, John A; van Hout, Ben

    2011-12-30

    This study sought to map the Insomnia Severity Index (ISI) and symptom variables onto the EQ-5D. A cross-sectional survey was conducted among adult US residents with self-reported sleep problems. Respondents provided demographic, comorbidity, and sleep-related information and had completed the ISI and the EQ-5D profile. Respondents were classified into ISI categories indicating no, threshold, moderate, or severe insomnia. Generalized linear models (GLM) were used to map the ISI's 7 items (Model I), summary scores (Model II), clinical categories (Model III), and insomnia symptoms (Model IV), onto the EQ-5D. We used 50% of the sample for estimation and 50% for prediction. Prediction accuracy was assessed by mean squared errors (MSEs) and mean absolute errors (MAEs). Mean (standard deviation) sleep duration for respondents (N = 2,842) was 7.8 (1.9) hours, and mean ISI score was 14.1 (4.8). Mean predicted EQ-5D utility was 0.765 (0.08) from Models I-III, which overlapped with observed utilities 0.765 (0.18). Predicted utility using insomnia symptoms was higher (0.771(0.07)). Based on Model I, predicted utilities increased linearly with improving ISI (0.493 if ISI = 28 vs. 1.00 if ISI = 0, p sleep-duration function of the EQ-5D; thus, utilities diminished after an optimal amount of sleep. The MSEs/MAEs were substantially lower when predicting EQ-5D > 0.40, and results were comparable in all models. Findings suggest that mapping relationships between the EQ-5D and insomnia measures could be established. These relationships may be used to estimate insomnia-related treatment effects on health state utilities.

  4. Innovation and the future of advanced dosimetry: 2D to 5D

    Science.gov (United States)

    Oldham, Mark

    2017-05-01

    Recent years have witnessed a remarkable evolution in the techniques, capabilities and applications of 3D dosimetry. Initially the goal was simple: to innovate new techniques capable of comprehensively measuring and verifying exquisitely intricate dose distributions from a paradigm changing emerging new therapy, IMRT. Basic questions emerged: how well were treatment planning systems modelling the complex delivery, and how could treatments be verified for safe use on patients? Since that time, equally significant leaps of innovation have continued in the technology of treatment delivery. In addition, clinical practice has been transformed by the addition of on-board imaging capabilities, which tend to hypo-fractionation strategies and margin reduction. The net result is a high stakes treatment setting where the clinical morbidity of any unintended treatment deviation is exacerbated by the combination of highly conformal dose distributions given with reduced margins with fractionation regimens unfriendly to healthy tissue. Not surprisingly this scenario is replete with challenges and opportunities for new and improved dosimetry systems. In particular tremendous interest exists in comprehensive 3D dosimetry systems, and systems that can resolve the dose in moving structures (4D) and even in deforming structures (5D). Despite significant progress in the capability of multi-dimensional dosimetry systems, it is striking that true 3D dosimetry systems are today largely found in academic institutions or specialist clinics. The reasons will be explored. We will highlight innovations occurring both in treatment delivery and in advanced dosimetry methods designed to verify them, and explore current and future opportunities for advanced dosimetry tools in clinical practice and translational research.

  5. Reducing NPR 7120.5D to Practice: Preparing for a Life-Cycle Review

    Science.gov (United States)

    Taylor, Randall L.

    2008-01-01

    In March 2007, NASA issued revised rules for space flight project management, NPR 7120.5D, 'NASA Space Flight Program and Project Management Requirements.' Central to the new rules was the construct of Key Decision Points, maturity gates that the project team must pass in order to continue development. In order that the KDP decision be fully informed, the NPR required, as entrance criteria for the gate, the generation and delivery of specified planning, technical, and cost/schedule documents (gate products) and a life-cycle review, the Preliminary Design Review. Building on JPL experience on the Prometheus and Juno projects, the team successfully organized for and conducted these reviews on an aggressive schedule. Key actions were taken to proactively interact with the SRB, produce high-quality gate products with stakeholder review, generate review presentation materials, and handle a myriad of supporting logistical functions. A review preparation team was established, including a Review Captain and leads for documentation, information systems, and logistics, and their roles, responsibilities and task assignments were identified. Aids were produced, including a detailed review preparation schedule and a comprehensive gate products production table. Institutional support was leveraged early and often. Implementation strategy reflected the needs of a nationally-distributed team, as well as applicable export control and IT security requirements. This paper gives a brief overview of the GRAIL mission and its project management challenges, provides a detailed description of project PMSR and PDR preparation and execution activities, including positive and negative lessons learned, and identifies recommendations for future NASA (and non-NASA) project teams.

  6. Multidecadally resolved Asian summer monsoon dynamics during MIS 5a-5d

    Science.gov (United States)

    Shen, C. C.; Jiang, X.; Hu, H. M.; Spoetl, C.

    2016-12-01

    A strong correlation between the Asian summer monsoon (ASM) and the North Atlantic climate on millennial and sub-millennial timescales during the last glacial period (MIS 4-2) and deglacial sequence has been demonstrated. However, our knowledge of this millennial- and sub-millennial-scale climatic link before MIS 4 is limited. Here, we present a new U-Th-dated absolute chronology of ASM variability from 113.5 to 86.6 kyr BP, covering marine isotope stages (MIS) 5a-5d. This integrated multidecadally resolved record, based on 1435 oxygen isotope data and 46 U-Th dates with 2-sigma errors as low as ±0.3 kyr from three stalagmites collected in Sanxing Cave, southwestern China, can be a reference for calibrating paleoclimate proxy sequences. The Sanxing oxygen isotope record follows the 23 kyr precessional cycle of insolation and is punctuated by prominent millennial-scale oscillations of the Chinese Interstadials (CIS) 25 to 22, corresponding to Greenland Interstadials (GIS) 25 to 22. A centennial-scale precursor event at 104.1 ± 0.3 kyr BP preceding CIS 23 is clearly registered. These events in the Sanxing record are synchronous with those identified in stalagmites from the European Alps (NALPS), except for the onset of GIS 25 and the end of GIS 22, and are up to 2.3 kyr older than the corresponding ones in Greenland ice core records. The high degree of similarity of the oxygen isotope records between Sanxing Cave and Greenland supports the northern hemisphere forcing of the ASM. The anti-phase relationship of oxygen isotope records between Sanxing stalagmites and Antarctic ice cores suggests an additional ASM linkage to the Southern Hemisphere.

  7. Evolution of Anisotropic Turublence in Drifting Proton-Alpha Plasma - 2.5D Hybrid Simulations

    Science.gov (United States)

    Maneva, Y. G.; Poedts, S.; Vinas, A. F.

    2016-12-01

    In-situ measurements from various solar wind spacecraft indicate the presence of anisotropic turbulence with different spectral slopes of the magnetic field power spectra in parallel and perpendicular directions with respect to the orientation of the background magnetic field. Furthermore, both the parallel and the perpendicular energy spectra steepen as we reach the dissipation range and we observe multiple spectral breaks at the ion scales and beyond. The turbulent dissipation of magnetic field fluctuations at the sub-ion scales is believed to go into local ion heating and acceleration, so that the spectral breaks are typically associated with particle energization. The gained energy can be in the form of anisotropic heating, formation of non-thermal features in the particle velocity distributions functions, and redistribution of the differential acceleration between the different ion populations. To study the relation between the evolution of the anisotropic turbulent spectra and the particle heating at the ion and sub-ion scales we perform a series of 2.5D hybrid simulations in a drifting proton-alpha plasma. We neglect the fast electron dynamics and treat the electrons as an isothermal fluid electrons, whereas the protons and the minor population of alpha particles are evolved in a fully kinetic manner. We start with a given wave spectrum and study the evolution of the magnetic field spectral slopes as a function of the parallel and perpendicular wave-numbers. Simultaneously, we track the particle response and the energy exchange between the parallel and perpendicular scales in the presence of drifting proton-alpha population in the collisionless solar wind plasma. The results of the study show anisotropic behavior of the turbulent power spectra with steeper slopes along the magnetic field and slower dissipation in perpendicular direction.

  8. Interplay of spin-orbit coupling, correlations, and crystal anisotropy in 5d oxides

    Science.gov (United States)

    Hozoi, Liviu

    2013-03-01

    We investigate the correlated d-level electronic structure of 5 d Ir and Os oxide compounds by fully ab initio quantum-chemical many-body calculations on finite embedded clusters. The wave-function quantum-chemical methods provide a promising alternative to density-functional-based approaches to the electronic structure of solids. The computed d- d excitations in square-lattice, honeycomb, pyrochlore, and chain-like iridates compare well with recent RIXS (resonant inelastic x-ray scattering) data. We also perform a detailed analysis of the relativistic spin-orbit wave functions and compute observables such as the ground-state expectation value of the spin-orbit operator. The latter is in principle accessible from x-ray absorption and provides information on the role of t2 g- eg couplings in the ground-state wave function and on the strength of non-cubic fields that lift the degeneracy of the t2 g levels. As concerns the departure from cubic symmetry, interesting effects are found in A2Ir2O7 pyrochlores, where the highly anisotropic, hexagonal configuration of the adjacent A-site ions breaks cubic symmetry even in the absence of O-ligand trigonal distortions and moreover competes with the latter. Our findings open new perspectives in pyrochlore oxides. In 227 iridates, the outcome of this competition is decisive for the actual realization of any type of non-trivial topological ground state. In 227 spin systems with S > 1 / 2 , e.g., Cd2Os2O7, this interplay decides the sign of the single-ion anisotropy and the degree of magnetic frustration.

  9. Extension of a Fast GLRT Algorithm to 5D SAR Tomography of Urban Areas

    Directory of Open Access Journals (Sweden)

    Alessandra Budillon

    2017-08-01

    Full Text Available This paper analyzes a method for Synthetic Aperture Radar (SAR Tomographic (TomoSAR imaging, allowing the detection of multiple scatterers that can exhibit time deformation and thermal dilation by using a CFAR (Constant False Alarm Rate approach. In the last decade, several methods for TomoSAR have been proposed. The objective of this paper is to present the results obtained on high resolution tomographic SAR data of urban areas, by using a statistical test for detecting multiple scatterers that takes into account phase variations due to possible deformations and/or thermal dilation. The test can be evaluated in terms of probability of detection (PD and probability of false alarm (PFA, and is based on an approximation of a Generalized Likelihood Ratio Test (GLRT, denoted as Fast-Sup-GLRT. It was already applied and validated by the authors in the 3D case, while here it is extended and experimented in the 5D case. Numerical experiments on simulated and on StripMap TerraSAR-X (TSX data have been carried out. The presented results show that the adopted method allows the detection of a large number of scatterers and the estimation of their position with a good accuracy, and that the consideration of the thermal dilation and surface deformation helps in recovering more single and double scatterers, with respect to the case in which these contributions are not taken into account. Moreover, the capability of method to provide reliable estimates of the deformations in urban structure suggests its use in structure stress monitoring.

  10. Understanding the relationship between the EQ-5D, SF-6D, HAQ and disease activity in inflammatory arthritis.

    LENUS (Irish Health Repository)

    Adams, Roisin

    2012-02-01

    BACKGROUND: The growth of economic analyses and in particular cost-utility analyses (CUA), which use the QALY as a measure of outcome, has heightened the interest in the methodologies used to calculate the QALY. The EQ-5D has produced quite different utility values from that of the SF-6D. This article seeks to understand these differences using a cohort of patients with inflammatory arthritis. OBJECTIVE: To examine the relationship between the disease-specific measure, Health Assessment Questionnaire (HAQ) disability index (DI) and the preference-based measures, SF-6D, EQ-5D and European League Against Arthritis (EULAR) Disease Activity Score (DAS) in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS: Patients with RA and PsA (n = 504) attending a tertiary rheumatology referral centre completed the HAQ, SF-6D and the EQ-5D before starting biological therapy and again 12 months later. The SF-36 was converted into a utility using the preference-based SF-6D. Clinical outcomes such as the DAS, joint counts and laboratory measures were also recorded. We calculated single index utility scores from the preference-based instruments using UK population norms. We used regression analysis to derive a mapping function and calculated utility scores from the HAQDI and the DAS 28. RESULTS: The mean utility observed at baseline for RA was 0.43 for the EQ-5D and 0.54 for the SF-6D and for PsA was 0.49 for the EQ-5D and 0.57 for the SF-6D. The utility gain demonstrated by the EQ-5D was over twice that of the SF-6D. The EQ-5D scored 17% of the RA group as less than 0 (state defined as worse than death); 7% of this group remained less than 0 at follow-up. The distribution of the utility estimates was similar for both RA and PsA. CONCLUSIONS: Our findings draw attention to the impact of states worse than death on the overall distribution for the EQ-5D derived utilities and how these impact on its use in practice. EQ-5D-derived QALY changes are over twice

  11. Mapping the Beck Depression Inventory to the EQ-5D-3L in Patients with Depressive Disorders.

    Science.gov (United States)

    Grochtdreis, Thomas; Brettschneider, Christian; Hajek, Andr; Schierz, Katharina; Hoyer, Juergen; Koenig, Hans-Helmut

    2016-06-01

    For cost-utility analyses, data on health state utilities, as provided by the EQ-5D-3L, is needed but not always available. This study specified mapping algorithms from the Beck Depression Inventory (BDI) index to the EQ-5D-3L index adjusted for specific socio-demographic variables for patients with depressive disorders. The objective of this study was to specify mapping algorithms from the BDI index to the preference-based EQ-5D index for patients with depressive disorders, adjusting for specific socio-demographic variables. A sample of 1,074 consecutive patients with depressive disorders from a psychotherapeutic outpatient clinic was included in the study. Standardized clinical interviews were applied to establish reliable diagnoses. For the prediction of the EQ-5D-3L index from the BDI index and selected patient socio-demographic characteristics, ordinary least squares regression with robust standard errors was used. Model prediction properties were tested using the root mean squared error and repeated random sub-sampling cross-validation. The BDI index predicted the EQ-5D-3L index with a significant proportion of variance explained. The highest model goodness of fit was estimated for models with the BDI index and age as independent variables. The root mean squared error of the predicted EQ-5D-3L index in the validation samples was 0.23 for all models. The mean observed EQ-5D-3L index values and the mean predicted EQ-5D-3L index values seemed not to differ between models. However, a reduction of variability using cross-validation led to those (rather) accurate mean predicted values. One limitation of this study was the restricted generalizability. Moreover, some uncertainty was introduced in model predictive performance by usage of a dependent estimation sample for validation. The specified mapping algorithms from the BDI index to the EQ-5D-3L index for patients with depressive disorders are acceptable as approximation in cost-utility analyses. A further

  12. The benefits of, and barriers to, implementation of 5D BIM for quantity surveying in New Zealand

    Directory of Open Access Journals (Sweden)

    Ryan Stanley

    2014-03-01

    Full Text Available Building Information Modelling (BIM models are relational and parametric in nature, and 5D BIM is where model objects include specification data and other properties which can be directly used for pricing construction work. There is huge potential for its use by quantity surveyors (QSs for such tasks as quantity take-offs, estimation and cost management, in a collaborative project environment. Perceptions regarding the benefits of, and barriers to, the implementation of 5D BIM by quantity surveyors in Auckland are presented, based on structured interviews with 8 QSs. Results suggest that 5D BIM may provide advantages over traditional forms of quantity surveying in Auckland by increasing efficiency, improving visualization of construction details, and earlier risk identification. However there are perceived barriers to 5D BIM implementation within the construction industry: a lack of software compatibility; prohibitive set-up costs; a lack of protocols for coding objects within building information models; lack of an electronic standard for coding BIM software, and the lack of integrated models, which are an essential pre-requisite for full inter-operability, and hence collaborative working, in the industry. Further research is recommended, to find solutions to overcome these barriers to inter-operability between 3D and 5D BIM, in order to facilitate the cost modelling process.

  13. Methanogenesis from acetate: enrichment studies.

    Science.gov (United States)

    Baresi, L; Mah, R A; Ward, D M; Kaplan, I R

    1978-01-01

    An acetate enrichment culture was initiated by inoculating anaerobic sludge from a mesophilic methane digestor into a mineral salts medium with calcium acetate as the sole carbon and energy source. This enrichment was maintained indefinitely by weekly transfer into medium of the same composition. A study of this enrichment disclosed an unexpected age-dependent inhibition of methanogenesis by H2 and formate which apparently differed from the inhibition by chloroform and benzyl viologen. This age-dependent inhibition indicated that microbial interactions of the mixed enrichment population may play a regulatory role in methane formation. Futhermore, stimulation of methanogenesis in the acetate enrichment by addition of yeast extract showed a nutrient limitation which indicated that syntrophic interactions leading to formation of growth factors may also occur. A model is presented to illustrate the possible interrelationships between methanogenic and nonmethanogenic bacteria in their growth and formation of methane and carbon dioxide from acetate. Images PMID:697356

  14. 2.5d teleseismic waveform tomography with application to the tien shan

    Science.gov (United States)

    Baker, Benjamin Ian

    The analysis of passive source seismic data recorded by quasi-linear deployments of broadband stations at teleseismic distances has proven to be an effective means of probing the subsurface of the Earth. However, current methodologies are far from being able to exploit all the interpretable signal in these data sets. In this thesis, I describe a 2.5D, frequency domain, visco-elastic waveform tomography algorithm for imaging with this type of data. To compute synthetic seismograms (the forward problem), the general equations of motion are discretized with p-adaptive finite elements. This approach allows for geometric flexibility and accurate solutions as a function of wavelength. Artificial force distributions manifesting Huygen's principle for the teleseismic events are introduced locally through a Bielak layer. Because of the relatively low frequency content of teleseismic data, regional scale tectonic settings can be parameterized with a modest number of variables and perturbations can be determined directly from a regularized Gauss-Newton system of equations. Waveforms generated by the forward problem compare well with analytic solutions for simple 1D media and with those generated in heterogeneous structures by a finite difference technique. It is demonstrated through examples that the regularized approximate Hessian is particularly effective at focusing backpropagated residuals to their true location. It is observed that full waveform inversion can provide significantly better vertical resolution than arrival time tomography and significantly better lateral resolution than standard surface wave tomography. Used in tandem in a multi-scale approach, surface wave tomography followed by joint surface wave/body wave tomography is shown to be an effective strategy for image reconstruction from a simple starting model. This inversion strategy is then applied to body and surface wave teleseismic waves recorded in the Tien Shan. The work of previous investigators is

  15. Marine controlled-source electromagnetic sounding on submarine massive sulphides using 2.5-D simulation

    Science.gov (United States)

    Imamura, N.; Goto, T.; Takekawa, J.; Mikada, H.

    2010-12-01

    Recently, controlled-source electromagnetic (EM) method is widely used for shallow sub-seafloor explorations. In conventional marine CSEM methods, we need to connect a survey vehicle and an EM transmitter using a long cable, and also connect the EM transmitter and towed receiver using a cable. However, in practice, we must tow cables far from seafloor because of rough topography (e.g, chimneys) around submarine massive sulphides (SMS). Therefore, it is difficult to get information about shallow sub-seafloor structure. In this paper, we propose a new controlled-source electromagnetic method using two autonomous underwater vehicles (AUVs) for the exploration of SMS. We set an EM transmitter to one AUV, and also set an EM receiver to another AUV. Using this method, it is possible to keep a low height of diving AUVs from the seafloor, so we can carry out the exploration of SMS effectively. A numerical simulation code for 2.5 dimensional (2.5-D) electromagnetic fields in the frequency domain is developed in order to estimate electromagnetic responses on possible conductivity structures. In this research, we compared the behavior of electric fields as various functions such as the distance between source and receiver, and discussed the possibility of our CSEM method to be applied for the exploration of SMS. From the simulation results, we found that it is possible to detect the electric field for about 150~200m offsets even under the contamination of noise. Among various combination of source and receivers, we also found that the anomalous amplitude rate becomes greatest, in particular around the edge of SMS, when polarizing both the source and receiver in the horizontal direction. We next considered the sensitivity of electromagnetic field to the location of SMS using two model calculations. We found that the received electric field becomes steeply weaker as setting the receiver apart from the transmitter when the source was placed near SMS. Above all numerical

  16. Modeling plasticity of MgO at the mesoscale using 2.5D Dislocation Dynamics.

    Science.gov (United States)

    Reali, R.; Boioli, F.; Gouriet, K.; Carrez, P.; Cordier, P.

    2016-12-01

    In the lower mantle, viscosity results from the rheological behavior of its two main constituent minerals, namely (Mg,Fe)SiO3 bridgmanite and (Mg,Fe)O ferropericlase. Understanding how these phases deform is thus of primary importance in geophysics. This is also a very challenging task, since the extreme conditions to which the lower mantle aggregate is subjected are barely reachable in laboratory experiments.In this study, the contribution of dislocations to the deformation of periclase at the mesoscale is investigated by Dislocation Dynamics (DD) simulations, a modeling tool which considers the collective motion and interactions of dislocations. To model their behavior a so-called 2.5D DD approach is employed. Within this method, dislocations are considered as straight segments perpendicular to a 2D reference plane and local rules are added to mimic 3D behavior [1]. In this framework, both the glide and climb mechanisms can be taken into account [2].Before simulating the deformation of MgO under P, T and strain rate conditions of the lower mantle, it is necessary to benchmark the model at ambient pressure, in order to compare the simulated behavior with experiments performed in the same conditions.At high temperatures (1500-1800 K) the observed creep strain rates are controlled by the competition between dislocation glide and climb mechanisms, the former being responsible for strain production and the latter being the rate-limiting factor.Results are found in agreement with previous experimental data, confirming that the underlying physical processes are well described and permitting further investigations of MgO plasticity in the Earth's interior environment. We present the results obtained from simulations run at different temperatures and pressures within the lower mantle range of conditions. The possibility to constrain deformation with respect to time allows a characterization of the relationship between stresses and strain rates, a feature that wasn

  17. Structures of the dehydrogenation products of methane activation by 5d transition metal cations.

    Science.gov (United States)

    Lapoutre, V J F; Redlich, B; van der Meer, A F G; Oomens, J; Bakker, J M; Sweeney, A; Mookherjee, A; Armentrout, P B

    2013-05-23

    The activation of methane by gas-phase transition metal cations (M(+)) has been studied extensively, both experimentally and using density functional theory (DFT). Methane is exothermically dehydrogenated by several 5d metal ions to form [M,C,2H](+) and H2. However, the structure of the dehydrogenation product has not been established unambiguously. Two types of structures have been considered: a carbene structure where an intact CH2 fragment is bound to the metal (M(+)-CH2) and a carbyne (hydrido-methylidyne) structure with both a CH and a hydrogen bound to the metal separately (H-M(+)-CH). For metal ions with empty d-orbitals, an agostic interaction can occur that could influence the competition between carbene and carbyne structures. In this work, the gas phase [M,C,2H](+) (M = Ta, W, Ir, Pt) products are investigated by infrared multiple-photon dissociation (IR-MPD) spectroscopy using the Free-Electron Laser for IntraCavity Experiments (FELICE). Metal cations are formed in a laser ablation source and react with methane pulsed into a reaction channel downstream. IR-MPD spectra of the [M,C,2H](+) species are measured in the 300-3500 cm(-1) spectral range by monitoring the loss of H (2H in the case of [Ir,C,2H](+)). For each system, the experimental spectrum closely resembles the calculated spectrum of the lowest energy structure calculated using DFT: for Pt, a classic C(2v) carbene structure; for Ta and W, carbene structures that are distorted by agostic interactions; and a carbyne structure for the Ir complex. The Ir carbyne structure was not considered previously. To obtain this agreement, the calculated harmonic frequencies are scaled with a scaling factor of 0.939, which is fairly low and can be attributed to the strong redshift induced by the IR multiple-photon excitation process of these small molecules. These four-atomic species are among the smallest systems studied by IR-FEL based IR-MPD spectroscopy, and their spectra demonstrate the power of IR

  18. Hydrogen-enriched fuels

    Energy Technology Data Exchange (ETDEWEB)

    Roser, R. [NRG Technologies, Inc., Reno, NV (United States)

    1998-08-01

    NRG Technologies, Inc. is attempting to develop hardware and infrastructure that will allow mixtures of hydrogen and conventional fuels to become viable alternatives to conventional fuels alone. This commercialization can be successful if the authors are able to achieve exhaust emission levels of less than 0.03 g/kw-hr NOx and CO; and 0.15 g/kw-hr NMHC at full engine power without the use of exhaust catalysts. The major barriers to achieving these goals are that the lean burn regimes required to meet exhaust emissions goals reduce engine output substantially and tend to exhibit higher-than-normal total hydrocarbon emissions. Also, hydrogen addition to conventional fuels increases fuel cost, and reduces both vehicle range and engine output power. Maintaining low emissions during transient driving cycles has not been demonstrated. A three year test plan has been developed to perform the investigations into the issues described above. During this initial year of funding research has progressed in the following areas: (a) a cost effective single-cylinder research platform was constructed; (b) exhaust gas speciation was performed to characterize the nature of hydrocarbon emissions from hydrogen-enriched natural gas fuels; (c) three H{sub 2}/CH{sub 4} fuel compositions were analyzed using spark timing and equivalence ratio sweeping procedures and finally; (d) a full size pick-up truck platform was converted to run on HCNG fuels. The testing performed in year one of the three year plan represents a baseline from which to assess options for overcoming the stated barriers to success.

  19. Assessing quality of life in patients with hard-to-heal ulcers using the EQ-5D questionnaire.

    Science.gov (United States)

    Oien, R F; Akesson, N; Forssell, H

    2013-08-01

    To assess health-related quality of life (HRQoL) in an unselected patient population with hard-to-heal ulcers from baseline through healing and at follow-up 6 months after healing. Fifty patients were recruited and the sex and age of the patient and the ulcer aetiology, duration, and size were recorded. The generic instrument EQ-5D was used for two purposes. The first was to investigate the feasibility of this instrument for assessing HRQoL in this patient group. The second was to see if the EQ-5D results would add information to the Swedish Registry of Ulcer Treatment (RUT), a national quality registry which includes variables for pain, disturbed sleep, and mobility. We found a significant difference in HRQoL between patients with an open ulcer and those with a healed ulcer (p=0.02), but no significant difference between patients with a just-healed ulcer and patients at follow-up six months after ulcer healing (p=0.08). Sex, age, and length of ulcer duration at inclusion did not influence HRQoL (p=0.55, p=0.4, and p=0.9, respectively). Ulcer size seemed to influence HRQoL, though not significantly (p=0.07). This study confirms that HRQoL was improved after ulcer healing. Pain, as one of the five constructs measured by the EQ-5D, was significantly associated with open ulcers. The results from the EQ-5D questionnaire were hard to interpret in terms of capturing HRQoL in this unselected patient population. Despite some limitations, we consider that the simplicity of EQ-5D could make it feasible to use in the clinical setting. However, the results from EQ-5D did not add consistent information to RUT; therefore, this questionnaire will not be included in the registry.

  20. Canadian valuation of EQ-5D health states: preliminary value set and considerations for future valuation studies.

    Science.gov (United States)

    Bansback, Nick; Tsuchiya, Aki; Brazier, John; Anis, Aslam

    2012-01-01

    The EQ-5D is a preference based instrument which provides a description of a respondent's health status, and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calculations (QALY) in economic evaluations. However, values for health states have been found to differ between countries. The objective of this study was to develop a set of values for the EQ-5D health states for use in Canada. Values for 48 different EQ-5D health states were elicited using the Time Trade Off (TTO) via a web survey in English. A random effect model was fitted to the data to estimate values for all 243 health states of the EQ-5D. Various model specifications were explored. Comparisons with EQ-5D values from the UK and US were made. Sensitivity analysis explored different transformations of values worse than dead, and exclusion criteria of subjects. The final model was estimated from the values of 1145 subjects with socio-demographics broadly representative of Canadian general population with the exception of Quebec. This yielded a good fit with observed TTO values, with an overall R2 of 0.403 and a mean absolute error of 0.044. A preference-weight algorithm for Canadian studies that include the EQ-5D is developed. The primary limitations regarded the representativeness of the final sample, given the language used (English only), the method of recruitment, and the difficulty in the task. Insights into potential issues for conducting valuation studies in countries as large and diverse as Canada are gained.

  1. The EQ-5D (Euroqol is a valid generic instrument for measuring quality of life in patients with dyspepsia

    Directory of Open Access Journals (Sweden)

    Goh Khean-Lee

    2009-03-01

    Full Text Available Abstract Background There is little information of the validity of generic instruments in measuring health-related quality of life (HRQOL in patients with dyspepsia. We aimed to assess the reliability and validity of the EQ-5D, a brief and simple instrument, in measuring HRQOL in adult patients with dyspepsia. Methods Consecutive adults with dyspepsia attending the Gastroenterology clinic in a tertiary referral center were interviewed with the EQ-5D (both English and Malay versions, the short-form Nepean Dyspepsia Index (SF-NDI, the SF-36 and Leeds Dyspepsia Questionnaire (LDQ. Known-groups and convergent construct validity were investigated by testing hypotheses at attribute and overall levels. A repeat telephone interview was conducted 2 weeks later to assess test-retest reliability. Results A total of 113 patients (mean (SD age: 53.7 (14 years; 49.5% male; 24.8% Malays, 37.2% Chinese; 70.8% functional dyspepsia were recruited. Response rate was 100% with nil missing data. Known-groups validation revealed 20/26 hypotheses fulfillment. Patients with more severe dyspepsia reported more problems with their usual activity (p = 0.07 and pain (p = 0.06 and demonstrated lower median VAS scores (60 vs 70, p = 0.002 and EQ-5D utility scores (0.72 vs 0.78, p = 0.002. Those reporting problems in various EQ-5D dimensions had significantly lower scores in relevant SF-36 and SF-NDI dimensions. The overall EQ-5D utility score also demonstrated good correlation with the SF-36 summary physical and mental scores and the SF-NDI total score. Intraclass correlation coefficient for test-retest reliability was 0.66 (95% CI = 0.55 – 0.76. Conclusion The EQ-5D is an acceptable, valid and reliable generic instrument for measuring HRQOL in adult patients with dyspepsia.

  2. Quality of life profile and psychometric properties of the EQ-5D-5L in HIV/AIDS patients

    Directory of Open Access Journals (Sweden)

    Tran Bach

    2012-11-01

    Full Text Available Abstract Objectives We assessed health-related quality of life (HRQOL, its associated factors, and examined measurement properties of the EuroQol - 5 Dimensions - 5 Levels (EQ-5D-5L in HIV/AIDS patients. Methods A cross-sectional multi-site survey was conducted in 1016 patients (age: 35.4 ± 7.0 years; 63.8% male in three epicenters of Vietnam. Internal consistency reliability, convergent validity, and discriminative validity of the EQ-5D-5L and a visual analogue scale (VAS were evaluated. Tobit censored regression models were used to identify predictors of HRQOL in HIV/AIDS patients. Results The mean EQ-5D-5L single index and VAS were 0.65 (95% Confidence Interval (CI = 0.63; 0.67 and 70.3 (95% CI = 69.2; 71.5. Cronbach’s alpha of five dimensions was 0.85. EQ-5D-5L has a good convergent validity with VAS (0.73. It discriminated patients at different HIV/AIDS stages, duration of ART, and CD4 cell count. Predictors of poorer HRQOL included being female, lower education level, unemployment, alcohol and drug use, CD4 Conclusion The EQ-5D-5L has good measurement properties in HIV/AIDS patients and holds potentials for monitoring ART outcomes. Integration of HRQOL measurement using EQ-5D-5L in HIV/AIDS clinical practice could be helpful for economic evaluation of HIV/AIDS interventions.

  3. Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies

    Science.gov (United States)

    Bansback, Nick; Tsuchiya, Aki; Brazier, John; Anis, Aslam

    2012-01-01

    Background The EQ-5D is a preference based instrument which provides a description of a respondent's health status, and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calculations (QALY) in economic evaluations. However, values for health states have been found to differ between countries. The objective of this study was to develop a set of values for the EQ-5D health states for use in Canada. Methods Values for 48 different EQ-5D health states were elicited using the Time Trade Off (TTO) via a web survey in English. A random effect model was fitted to the data to estimate values for all 243 health states of the EQ-5D. Various model specifications were explored. Comparisons with EQ-5D values from the UK and US were made. Sensitivity analysis explored different transformations of values worse than dead, and exclusion criteria of subjects. Results The final model was estimated from the values of 1145 subjects with socio-demographics broadly representative of Canadian general population with the exception of Quebec. This yielded a good fit with observed TTO values, with an overall R2 of 0.403 and a mean absolute error of 0.044. Conclusion A preference-weight algorithm for Canadian studies that include the EQ-5D is developed. The primary limitations regarded the representativeness of the final sample, given the language used (English only), the method of recruitment, and the difficulty in the task. Insights into potential issues for conducting valuation studies in countries as large and diverse as Canada are gained. PMID:22328929

  4. Assessing Health-Related Quality of Life of Chinese Adults in Heilongjiang Using EQ-5D-3L.

    Science.gov (United States)

    Huang, Weidong; Yu, Hongjuan; Liu, Chaojie; Liu, Guoxiang; Wu, Qunhong; Zhou, Jin; Zhang, Xin; Zhao, Xiaowen; Shi, Linmei; Xu, Xiaoxue

    2017-02-23

    This study aimed to assess health-related quality of life (HRQOL) of Heilongjiang adult populations by using the EuroQol five-dimension three-level (EQ-5D-3L) questionnaire and to identify factors associated with HRQOL. Data from the National Health Services Survey (NHSS) 2008 in Heilongjiang province were obtained. Results of EQ-5D-3L questionnaires completed by 11,523 adult respondents (18 years or older) were converted to health index scores using a recently developed Chinese value set. Multivariate linear regression and logistic regression models were established to determine demographic, socioeconomic, health, and lifestyle factors that were associated with HRQOL and reported problems in the five dimensions of EQ-5D-3L. The Heilongjiang population had a mean EQ-5D-3L index score of 0.959. Lower EQ-5D-3L index scores were associated with older age, lower levels of education, chronic conditions, temporary accommodation, poverty, unemployment, and lack of regular physical activities. Older respondents and those who were unemployed, had chronic conditions, and lived in poverty were more likely to report problems in all of the five health dimensions. Higher educational attainment was associated with lower odds of reporting health problems in mobility, pain/discomfort, and anxiety/depression. Low socioeconomic status is associated with poor HRQOL. Regional population norms for EQ-5D-3L are needed for health economic studies due to great socioeconomic disparities across regions in China. Overall, the Heilongjiang population has a similar level of HRQOL compared with the national average.

  5. The Na+ transporter, TaHKT1;5-D, limits shoot Na+ accumulation in bread wheat

    KAUST Repository

    Byrt, Caitlin Siobhan

    2014-10-01

    Bread wheat (Triticum aestivum L.) has a major salt tolerance locus, Kna1, responsible for the maintenance of a high cytosolic K+/Na+ ratio in the leaves of salt stressed plants. The Kna1 locus encompasses a large DNA fragment, the distal 14% of chromosome 4DL. Limited recombination has been observed at this locus making it difficult to map genetically and identify the causal gene. Here, we decipher the function of TaHKT1;5-D, a candidate gene underlying the Kna1 locus. Transport studies using the heterologous expression systems Saccharomyces cerevisiae and Xenopus laevis oocytes indicated that TaHKT1;5-D is a Na+-selective transporter. Transient expression in Arabidopsis thaliana mesophyll protoplasts and in situ polymerase chain reaction indicated that TaHKT1;5-D is localised on the plasma membrane in the wheat root stele. RNA interference-induced silencing decreased the expression of TaHKT1;5-D in transgenic bread wheat lines which led to an increase in the Na+ concentration in the leaves. This indicates that TaHKT1;5-D retrieves Na+ from the xylem vessels in the root and has an important role in restricting the transport of Na+ from the root to the leaves in bread wheat. Thus, TaHKT1;5-D confers the essential salinity tolerance mechanism in bread wheat associated with the Kna1 locus via shoot Na+ exclusion and is critical in maintaining a high K+/Na+ ratio in the leaves. These findings show there is potential to increase the salinity tolerance of bread wheat by manipulation of HKT1;5 genes.

  6. A review of Early Weichselian climate (MIS 5d-a) in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Wohlfarth, Barbara [Dept. of Geological Sciences, Stockholm Univ., Stockholm (Sweden)

    2013-06-15

    additional feedbacks. The end of the last interglacial, i.e. the Eemian or MIS5e, and the transition into the last glacial period was initially triggered by a decrease in incoming summer insolation at high northern latitudes. The change in orbital configuration subsequently led to a series of time-transgressive changes (e.g. gradual vegetation replacement; changes in sea surface temperature, salinity, strength of the North Atlantic Current). As Northern Hemisphere ice sheets started to grow and expand these changes became more and more pronounced. The sequence of events leading from the last interglacial into the last glacial has been described using climate models with different complexity and boundary conditions, paleodata series, and comparisons between model out put and paleo data. One possible scenario involves the development of summer sea ice in the northern North Atlantic already during the later part of the Eemian interglacial, as a response to decreasing summer insolation. This would have accelerated a vegetation shift, which in turn would have led to a decrease in albedo. More extensive sea ice could, through brine formation, have increased the Atlantic meridional overturning circulation, which would have supplied more moisture to the cold high northern latitudes. This in turn would have favoured the growth of ice sheets. A response of the vegetation in northern Europe to the decrease in summer insolation and to increased summer sea ice may be seen as early as 122-120 thousand years (ka) ago, but became most distinct around 115 ka, when North Atlantic sea surface temperatures show signs of a first minor cooling. This cold event (labelled sea surface cooling event C26) defines the Marine Isotope Stage (MIS) 5e/5d transition in marine cores and seems to correlate with Greenland stadial GS26. This first distinct cooling event on Greenland is paralleled by cold temperatures in Antarctica, which implies synchronous cooling in both hemispheres. However, while Antarctica

  7. 1.5D Quasilinear Model for Alpha Particle-TAE Interaction in ARIES ACT-I

    Energy Technology Data Exchange (ETDEWEB)

    K. Ghantous, N.N. Gorelenkov, C. Kessel, F. Poli

    2013-01-30

    We study the TAE interaction with alpha particle fusion products in ARIES ACT-I using the 1.5D quasilinear model. 1.5D uses linear analytic expressions for growth and damping rates of TAE modes evaluated using TRANSP pro les to calculates the relaxation of pressure pro les. NOVA- K simulations are conducted to validate the analytic dependancies of the rates, and to normalize their absolute value. The low dimensionality of the model permits calculating loss diagrams in large parameter spaces.

  8. An analysis of Euroqol EQ-5D and Manchester Oxford Foot Questionnaire scores six months following podiatric surgery

    Directory of Open Access Journals (Sweden)

    Maher Anthony J

    2012-07-01

    Full Text Available Abstract Background In the United Kingdom patient-reported outcome measures (PROMS have been adopted as a key measure of foot surgery outcomes. The intention of this study was to evaluate the responsiveness of a regional outcome measure; the Manchester Oxford Foot Questionnaire (MOXFQ and a generic measure; the EuroQol EQ-5D, in the context of day care Podiatric Surgery. Methods A prospective audit of 375 consecutive day care surgical admissions was undertaken. All patients attending for surgery, who agreed to participate, were included. Pre operation patients completed the MOXFQ and the EQ-5D. Both questionnaires were completed again at 6 months post operation. Additional data was collected on patient demographics, surgical procedures and complications. Results Few complications were encountered and most patients (84% returned for a final review 6 months post operation. Mean MOXFQ scores improved for each domain: pain; 51.7 pre-operation, reduced to 16.5 post-operation, walking; 50.2 reduced to 14.1 and social interaction; 45.7 reduced to 10.6. The minimal clinically important differences (MCID estimates for the pain domain were exceeded by 82.6% of patients, while 74.8% exceeded the MCID for walking and 68.5% exceeded the MCID for social interaction. A small number of patients (2.9% deteriorated across all three MOXFQ domains. The EQ-5D Index, summary of health related quality of life, improved from 0.66 pre-operation to 0.86 post operation. The EQ-5D index MCID was exceeded by 79.2% of patients. Index scores deteriorated for 1.8% of patients following surgery. Effect sizes measured following surgery were largest for the MOXFQ domains: Walking; 1.39, Pain; 1.52 and Social Interaction: 1.39. The EQ-5D index effect size was 0.83. The EQ-5D visual analogue scale (VAS was not influenced by surgery. Conclusion Both the MOXFQ and EQ-5D index (but not the VAS appear sensitive to changes in health status at 6 months following elective foot

  9. Development of the web-based Spanish and Catalan versions of the Euroqol 5D-Y (EQ-5D-Y) and comparison of results with the paper version.

    Science.gov (United States)

    Robles, Noemí; Rajmil, Luis; Rodriguez-Arjona, Dolors; Azuara, Marta; Codina, Francisco; Raat, Hein; Ravens-Sieberer, Ulrike; Herdman, Michael

    2015-06-03

    The objectives of the study were to develop web-based Spanish and Catalan versions of the EQ-5D-Y, and to compare scores and psychometric properties with the paper version. Web-based and paper versions of EQ-5D-Y were included in a cross-sectional study in Palafolls (Barcelona), Spain and administered to students (n = 923) aged 8 to 18 years from 2 primary and 1 secondary school and their parents. All students completed both the web-based and paper versions during school time with an interval of at least 2 h between administrations. The order of administration was randomized. Participants completed EQ-5D-Y, a measure of mental health status (the Strengths and Difficulties Questionnaire), and sociodemographic variables using a self-administered questionnaire. Parents questionnaire included parental level of education and presence of chronic conditions in children. Missing values, and floor and ceiling effects were compared between versions. Mean score differences were computed for the visual analogue scale (VAS). Percentage of agreement, kappa index (k) and intraclass correlation coefficient (ICC) were computed to analyze the level of agreement between web-based and paper versions on EQ-5D-Y dimensions and VAS. Known groups validity was analyzed and compared between the two formats. Participation rate was 77 % (n = 715). Both formats of EQ-5D-Y showed low percentages of missing values (n = 2, and 4 to 9 for web and paper versions respectively), and a high ceiling effect by dimension (range from 79 % to 96 %). Percent agreement for EQ-5D-Y dimensions on the web and paper versions was acceptable (range 89 % to 97 %), and k ranged from 0.55 (0.48-0.61, usual activities dimension) to 0.75 (0.68-0.82, mobility dimension). Mean score difference on the VAS was 0.07, and the ICC for VAS scores on the two formats was 0.84 (0.82-0.86). Both formats showed acceptable ability to discriminate according to self-perceived health, reporting chronic conditions, and

  10. Environmental enrichment for aquatic animals.

    Science.gov (United States)

    Corcoran, Mike

    2015-05-01

    Aquatic animals are the most popular pets in the United States based on the number of owned pets. They are popular display animals and are increasingly used in research settings. Enrichment of captive animals is an important element of zoo and laboratory medicine. The importance of enrichment for aquatic animals has been slower in implementation. For a long time, there was debate over whether or not fish were able to experience pain or form long-term memories. As that debate has reduced and the consciousness of more aquatic animals is accepted, the need to discuss enrichment for these animals has increased. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. New Prototype Safeguards Technology Offers Improved Confidence and Automation for Uranium Enrichment Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Brim, Cornelia P.

    2013-04-01

    An important requirement for the international safeguards community is the ability to determine the enrichment level of uranium in gas centrifuge enrichment plants and nuclear fuel fabrication facilities. This is essential to ensure that countries with nuclear nonproliferation commitments, such as States Party to the Nuclear Nonproliferation Treaty, are adhering to their obligations. However, current technologies to verify the uranium enrichment level in gas centrifuge enrichment plants or nuclear fuel fabrication facilities are technically challenging and resource-intensive. NNSA’s Office of Nonproliferation and International Security (NIS) supports the development, testing, and evaluation of future systems that will strengthen and sustain U.S. safeguards and security capabilities—in this case, by automating the monitoring of uranium enrichment in the entire inventory of a fuel fabrication facility. One such system is HEVA—hybrid enrichment verification array. This prototype was developed to provide an automated, nondestructive assay verification technology for uranium hexafluoride (UF6) cylinders at enrichment plants.

  12. 76 FR 9054 - Notice of Availability of Final Environmental Impact Statement for the AREVA Enrichment Services...

    Science.gov (United States)

    2011-02-16

    ... concentrations up to 5 percent by weight. The enriched uranium would be used to manufacture nuclear fuel for... resources, air quality, geology and soils, water resources, ecological resources, noise, transportation..., One White Flint North, 11555 Rockville Pike (first floor), Rockville, Maryland 20852. Members of the...

  13. A Program of Methodological Research to Arrive at the New International EQ-5D-5L Valuation Protocol

    NARCIS (Netherlands)

    Oppe, Mark; Devlin, Nancy J.; van Hout, Ben; Krabbe, Paul F.M.; de Charro, Frank

    OBJECTIVES: To describe the research that has been undertaken by the EuroQol Group to improve current methods for health state valuation, to summarize the results of an extensive international pilot program, and to outline the key elements of the five-level EuroQol five-dimensional (EQ-5D-5L)

  14. The distal portion of wheat (Triticum aestivum L.) chromosome 5D short arm controls endosperm vitreosity and grain hardness

    Science.gov (United States)

    Kernel vitreosity is an important trait of wheat grain, but its complete developmental control is not known. We developed back-cross seven (BC7) near isogenic lines in the soft white spring wheat cultivar Alpowa that possess or lack the distal portion of chromosome 5D short arm. This deletion was de...

  15. Phantom and inflation scenarios from a 5D vacuum through form-invariance transformations of the Einstein equations

    CERN Document Server

    Pucheu, Maria Laura

    2009-01-01

    We study phantom and inflationary cosmologies using form-invariance transformations of the Einstein equations with respect to $\\rho$, $H$, $a$ and $p$, from a 5D vacuum. Equations of state and squared fluctuations of the inflaton and phantom fields are examined.

  16. Lifetime determination of the 5d(2) F-3(2) state in barium using trapped atoms

    NARCIS (Netherlands)

    De, S.; Dammalapati, U.; Willmann, L.

    2015-01-01

    Magneto-optically trapped atoms enable the determination of lifetimes of metastable states and higher lying excited states like the 5d(2) F-3(2) state in barium. The state is efficiently populated by driving strong transitions from metastable states within the cooling cycle of the barium

  17. The burden of common skin diseases assessed with the EQ5D: a European multicentre study in 13 countries

    NARCIS (Netherlands)

    Balieva, F.; Kupfer, J.; Lien, L.; Gieler, U.; Finlay, A.Y.; Tomas-Aragones, L.; Poot, F.; Misery, L.; Sampogna, F.; Middendorp, H. van; Halvorsen, J.A.; Szepietowski, J.C.; Lvov, A.; Marron, S.E.; Salek, M.S.; Dalgard, F.J.

    2017-01-01

    BACKGROUND: Generic instruments measuring health-related quality of life (HRQoL), like EQ5D, enable comparison of skin diseases with healthy populations and nondermatological medical conditions, as well as calculation of utility data. OBJECTIVES: To measure HRQoL in patients with common skin

  18. Is it necessary to penalize impulsive noise +5 dB due to higher risk of hearing damage?

    DEFF Research Database (Denmark)

    de Toro, Miguel Angel Aranda; Ordoñez, Rodrigo Pizarro; Reuter, Karen

    2011-01-01

    It is studied whether the +5 dB penalty for impulsiveness established by ISO 1999:1990 accounts for a higher risk of noise-induced hearing loss. A total of 16 normal-hearing human subjects were exposed for 10 min to two types of binaural industrial-recordings: (1) a continuous broad-band noise no...

  19. The Scavenger Receptor SSc5D Physically Interacts with Bacteria through the SRCR-Containing N-Terminal Domain.

    Science.gov (United States)

    Bessa Pereira, Catarina; Bocková, Markéta; Santos, Rita F; Santos, Ana Mafalda; Martins de Araújo, Mafalda; Oliveira, Liliana; Homola, Jiří; Carmo, Alexandre M

    2016-01-01

    The scavenger receptor cysteine-rich (SRCR) family comprises a group of membrane-attached or secreted proteins that contain one or more modules/domains structurally similar to the membrane distal domain of type I macrophage scavenger receptor. Although no all-inclusive biological function has been ascribed to the SRCR family, some of these receptors have been shown to recognize pathogen-associated molecular patterns (PAMP) of bacteria, fungi, or other microbes. SSc5D is a recently described soluble SRCR receptor produced by monocytes/macrophages and T lymphocytes, consisting of an N-terminal portion, which contains five SRCR modules, and a large C-terminal mucin-like domain. Toward establishing a global common role for SRCR domains, we interrogated whether the set of five SRCR domains of SSc5D displayed pattern recognition receptor (PRR) properties. For that purpose, we have expressed in a mammalian expression system the N-terminal SRCR-containing moiety of SSc5D (N-SSc5D), thus excluding the mucin-like domain likely by nature to bind microorganisms, and tested the capacity of the SRCR functional groups to physically interact with bacteria. Using conventional protein-bacteria binding assays, we showed that N-SSc5D had a superior capacity to bind to Escherichia coli strains RS218 and IHE3034 compared with that of the extracellular domains of the SRCR proteins CD5 and CD6 (sCD5 and sCD6, respectively), and similar E. coli-binding properties as Spα, a proven PRR of the SRCR family. We have further designed a more sensitive, real-time, and label-free surface plasmon resonance (SPR)-based assay and examined the capacity of N-SSc5D, Spα, sCD5, and sCD6 to bind to different bacteria. We demonstrated that N-SSc5D compares with Spα in the capacity to bind to E. coli and Listeria monocytogenes, and further that it can distinguish between pathogenic E. coli RS218 and IHE3034 strains and the non-pathogenic laboratory E. coli strain BL21(DE3). Our work thus advocates the

  20. Online Resources

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Online Resources. Journal of Genetics. Online Resources. Volume 96. 2017 | Online resources. Volume 95. 2016 | Online resources. Volume 94. 2015 | Online resources. Volume 93. 2014 | Online resources. Volume 92. 2013 | Online resources. Volume 91. 2012 | Online resources ...

  1. Mapping PROMIS Global Health Items to EuroQol (EQ-5D) Utility Scores Using Linear and Equipercentile Equating.

    Science.gov (United States)

    Thompson, Nicolas R; Lapin, Brittany R; Katzan, Irene L

    2017-11-01

    Mapping Patient-Reported Outcomes Measurement Information System-Global Health (PROMIS-GH) to EuroQol 5-dimension, three-level version (EQ-5D-3L) provides a utility score for use in quality-of-life and cost-effectiveness analyses. In 2009, Revicki et al. mapped the PROMIS-GH items to EQ-5D-3L utilities using linear regression (REVReg). More recently, regression was shown to be ill-suited for mapping to preference-based measures due to regression to the mean. Linear and equipercentile equating are alternative mapping methods that avoid the issue of regression to the mean. Another limitation of the prior models is that ordinal predictors were treated as continuous. Using data collected from the PROMIS Wave 1 sample, we refit REVReg, treating the PROMIS-GH items as categorical variables (CATReg). We applied linear and equipercentile equating to the REVReg model (REVLE, REVequip) and the CATReg model (CATLE, CATequip). We validated and compared the predictive accuracy of these models in a large sample of neurological patients at a single tertiary-care hospital. In the neurological disease patient sample, CATLE produced the strongest correlations between estimated and observed EQ-5D-3L scores and had the lowest mean squared error. The CATequip model had the lowest mean absolute error and had estimated scores that best matched the overall distribution of observed scores. Using linear and equipercentile equating, we created new models mapping PROMIS-GH items to EQ-5D-3L utility scores. EQ-5D-3L utility scores can be more accurately estimated using our models for use in cost-effectiveness studies or studies examining overall health-related quality of life.

  2. Mapping of the Insomnia Severity Index and other sleep measures to EuroQol EQ-5D health state utilities

    Directory of Open Access Journals (Sweden)

    Gu Ning Yan

    2011-12-01

    Full Text Available Abstract Background This study sought to map the Insomnia Severity Index (ISI and symptom variables onto the EQ-5D. Methods A cross-sectional survey was conducted among adult US residents with self-reported sleep problems. Respondents provided demographic, comorbidity, and sleep-related information and had completed the ISI and the EQ-5D profile. Respondents were classified into ISI categories indicating no, threshold, moderate, or severe insomnia. Generalized linear models (GLM were used to map the ISI's 7 items (Model I, summary scores (Model II, clinical categories (Model III, and insomnia symptoms (Model IV, onto the EQ-5D. We used 50% of the sample for estimation and 50% for prediction. Prediction accuracy was assessed by mean squared errors (MSEs and mean absolute errors (MAEs. Results Mean (standard deviation sleep duration for respondents (N = 2,842 was 7.8 (1.9 hours, and mean ISI score was 14.1 (4.8. Mean predicted EQ-5D utility was 0.765 (0.08 from Models I-III, which overlapped with observed utilities 0.765 (0.18. Predicted utility using insomnia symptoms was higher (0.771(0.07. Based on Model I, predicted utilities increased linearly with improving ISI (0.493 if ISI = 28 vs. 1.00 if ISI = 0, p 0.40, and results were comparable in all models. Conclusions Findings suggest that mapping relationships between the EQ-5D and insomnia measures could be established. These relationships may be used to estimate insomnia-related treatment effects on health state utilities.

  3. Gamified Vocabulary: Online Resources and Enriched Language Learning

    Science.gov (United States)

    Abrams, Sandra Schamroth; Walsh, Sara

    2014-01-01

    This article explores the ways "gamification" can play a role in adolescents' development of vocabulary. Gamification involves the application of game-design thinking and play elements to non-game activities, such as routine homework or classroom lessons. Drawing upon data from in-school and after-school settings, the authors…

  4. Resource recovery from organic waste streams by microbial enrichment cultures

    NARCIS (Netherlands)

    Tamis, J.

    2015-01-01

    Polyhydroxyalkanoate (PHA) is a natural product that can potentially replace a part of the chemicals and plastics derived from fossil sources. One of the main barriers for market entry of PHA is its relatively high price compared to conventional (fossil) feedstocks. This high price is related to

  5. Neuroprotective effects of cognitive enrichment.

    Science.gov (United States)

    Milgram, Norton W; Siwak-Tapp, Christina T; Araujo, Joseph; Head, Elizabeth

    2006-08-01

    Cognitive enrichment early in life, as indicated by level of education, complexity of work environment or nature of leisure activities, appears to protect against the development of age-associated cognitive decline and also dementia. These effects are more robust for measures of crystallized intelligence than for measures of fluid intelligence and depend on the ability of the brain to compensate for pathological changes associated with aging. This compensatory ability is referred to as cognitive reserve. The cognitive reserve hypothesis suggests that cognitive enrichment promotes utilization of available functions. Alternatively, late life cognitive changes in cognition may be linked to a factor, such as cholinergic dysfunction, that is also present early in life and contributes to the reduced levels of early life cognitive enrichment. Beneficial effects of environmental enrichment early in life have also been observed in rodents and primates. Research with rodents indicates that these changes have structural correlates, which likely include increased synapses in specific brain regions. Dogs also show age-dependent cognitive decline, and both longitudinal and cross-sectional studies indicate that this decline can be attenuated by cognitive enrichment. Furthermore, cognitive enrichment has differential effects, improving some functions more than others. From a neurobiological perspective, behavioral enrichment in the dog may act to promote neurogenesis later in life. This can be distinguished from nutritional interventions with antioxidants, which appear to attenuate the development of neuropathology. These results suggest that a combination of behavioral and nutritional or pharmacological interventions may be optimal for reducing the rate of age-dependent cognitive decline.

  6. The antecedents and outcomes of work-family enrichment amongst female workers

    Directory of Open Access Journals (Sweden)

    Esandre Marais

    2014-02-01

    Full Text Available Orientation: Women are involved in both a work and a family domain. Work-family enrichment is a concept that describes how these domains can enrich each other through the transfer of resources from one domain to the other.Research purpose: The objective was to determine the relationship between work resources,home resources, work engagement, family engagement and work-family enrichment. The aim was also to test two models representing work-to-family and family-to-work enrichment as mediators.Motivation for the study: By investigating work-family enrichment, as a new research concept,and its antecedents and outcomes, this study will add to the positive side of the work-family interface literature and provide information to organisations.Research design, approach and method: A cross-sectional survey design was used in this study with a sample of female workers (N = 420 in South Africa. Polychoric correlations, fit indices, structural equation modelling and testing mediation were used to analyse the data.Omegas and alpha coefficients were employed to determine the reliability.Main findings: A positive relationship between work-family enrichment and its antecedents and outcomes was found. Furthermore, work-family enrichment (W-FE mediated (large effectthe relationship between work resources and work engagement and family-work enrichment mediated (small effect the relationship between home resources and family engagement.Practical/managerial implications: The results provide more insight and understanding to organisations and female workers on the benefits of being involved in both the domain of work life and the domain of family life.Contribution/value-add: The study contributes to the limited research undertaken on work family enrichment within the South African context. The present study also contributes to the literature on the use of the newly developed MACE Work-Family Enrichment Instrument.

  7. The EQ-5D-5L health status questionnaire in COPD: validity, responsiveness and minimum important difference.

    Science.gov (United States)

    Nolan, Claire M; Longworth, Louise; Lord, Joanne; Canavan, Jane L; Jones, Sarah E; Kon, Samantha S C; Man, William D-C

    2016-06-01

    The EQ-5D, a generic health status questionnaire that is widely used in health economic evaluation, was recently expanded to the EQ-5D-5L to address criticisms of unresponsiveness and ceiling effect. To describe the validity, responsiveness and minimum important difference of the EQ-5D-5L in COPD. Study 1: The validity of the EQ-5D-5L utility index and visual analogue scale (EQ-VAS) was compared with four established disease-specific health status questionnaires and other measures of disease severity in 616 stable outpatients with COPD. Study 2: The EQ-5D-5L utility index and EQ-VAS were measured in 324 patients with COPD before and after 8 weeks of pulmonary rehabilitation. Distribution and anchor-based approaches were used to estimate the minimum important difference. There were moderate-to-strong correlations between utility index and EQ-VAS with disease-specific questionnaires (Pearson's r=0.47-0.72). A ceiling effect was seen in 7% and 2.6% of utility index and EQ-VAS. Utility index decreased (worsening health status) with indices of worsening disease severity. With rehabilitation, mean (95% CI) changes in utility index and EQ-VAS were 0.065 (0.047 to 0.083) and 8.6 (6.5 to 10.7), respectively, with standardised response means of 0.39 and 0.44. The mean (range) anchor estimates of the minimum important difference for utility index and EQ-VAS were 0.051 (0.037 to 0.063) and 6.9 (6.5 to 8.0), respectively. The EQ-5D-5L is a valid and responsive measure of health status in COPD and may provide useful additional cost-effectiveness data in clinical trials. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  8. SU-F-T-122: 4Dand 5D Proton Dose Evaluation with Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Titt, U; Mirkovic, D; Yepes, P; Liu, A; Peeler, C; Randenyia, S; Mohan, R [UT MD Anderson Cancer Center, Houston, TX (United States)

    2016-06-15

    Purpose: We evaluated uncertainties in therapeutic proton doses of a lung treatment, taking into account intra-fractional geometry changes, such as breathing, and inter-fractional changes, such as tumor shrinkage and weight loss. Methods: A Monte Carlo study was performed using four dimensional CT image sets (4DCTs) and weekly repeat imaging (5DCTs) to compute fixed RBE (1.1) and variable RBE weighted dose in an actual lung treatment geometry. The MC2 Monte Carlo system was employed to simulate proton energy deposition and LET distributions according to a thoracic cancer treatment plan developed with a 3D-CT in a commercial treatment planning system, as well as in each of the phases of 4DCT sets which were recorded weekly throughout the course of the treatment. A cumulative dose distribution in relevant structures was computed and compared to the predictions of the treatment planning system. Results: Using the Monte Carlo method, dose deposition estimates with the lowest possible uncertainties were produced. Comparison with treatment planning predictions indicates that significant uncertainties may be associated with therapeutic lung dose prediction from treatment planning systems, depending on the magnitude of inter- and intra-fractional geometry changes. Conclusion: As this is just a case study, a more systematic investigation accounting for a cohort of patients is warranted; however, this is less practical because Monte Carlo simulations of such cases require enormous computational resources. Hence our study and any future case studies may serve as validation/benchmarking data for faster dose prediction engines, such as the track repeating algorithm, FDC.

  9. Semantic enrichment for medical ontologies.

    Science.gov (United States)

    Lee, Yugyung; Geller, James

    2006-04-01

    The Unified Medical Language System (UMLS) contains two separate but interconnected knowledge structures, the Semantic Network (upper level) and the Metathesaurus (lower level). In this paper, we have attempted to work out better how the use of such a two-level structure in the medical field has led to notable advances in terminologies and ontologies. However, most ontologies and terminologies do not have such a two-level structure. Therefore, we present a method, called semantic enrichment, which generates a two-level ontology from a given one-level terminology and an auxiliary two-level ontology. During semantic enrichment, concepts of the one-level terminology are assigned to semantic types, which are the building blocks of the upper level of the auxiliary two-level ontology. The result of this process is the desired new two-level ontology. We discuss semantic enrichment of two example terminologies and how we approach the implementation of semantic enrichment in the medical domain. This implementation performs a major part of the semantic enrichment process with the medical terminologies, with difficult cases left to a human expert.

  10. Herpes - resources

    Science.gov (United States)

    Genital herpes - resources; Resources - genital herpes ... following organizations are good resources for information on genital herpes : March of Dimes -- www.marchofdimes.com/pregnancy/complications- ...

  11. Electronic and magnetic behaviors of graphene with 5d series transition metal atom substitutions: A first-principles study

    Science.gov (United States)

    Sun, Minglei; Tang, Wencheng; Ren, Qingqiang; Zhao, Yiming; Wang, Sake; Yu, Jin; Du, Yanhui; Hao, Yitong

    2016-06-01

    The electronic structures and magnetic behaviors of graphene with 5d series transition metal atom substitutions are investigated by performing first-principles calculations. All the impurities are tightly bonded to single vacancy in a graphene sheet. The substitutions of La and Ta lead to Fermi level shifting to valence and conduction band, respectively. Both the two substitutions result in metallic properties. Moreover, the Hf, Os and Pt-substituted systems exhibit semiconductor properties, while the Re and Ir-substituted ones exhibit robust half-metallic properties. Interestingly, W-substituted system shows dilute magnetic semiconductor property. On the other hand, the substitution of Ta, W, Re and Ir induce 0.86 μB, 2 μB, 1 μB and 0.99 μB magnetic moment, respectively. Our studies demonstrate that the 5d series transition metal substituted graphene have potential applications in nanoelectronics, spintronics and magnetic storage devices.

  12. Prediction of cutting forces in ball-end milling of 2.5D C/C composites

    Directory of Open Access Journals (Sweden)

    Shan Chenwei

    2016-06-01

    Full Text Available Machining of carbon/carbon (C/C composite materials is difficult to carry out due to its high specific stiffness, brittleness, anisotropic, non-homogeneous and low thermal conductivity, which can result in tear, burr, poor surface quality and rapid wear of cutters. Accurate and fast prediction of cutting forces is important for milling C/C composite materials with high quality. This paper presents an alternative cutting force model involving the influences of the directions of fiber. Based on the calculated and experimental results, the cutting forces’ coefficients of 2.5D C/C composites are evaluated using multiple linear regression method. Verification experiment has been carried out through a group of orthogonal tests. Results indicate that the proposed model is reliable and can be used to predict the cutting forces in ball-end milling of 2.5D C/C composites.

  13. A program of methodological research to arrive at the new international EQ-5D-5L valuation protocol.

    Science.gov (United States)

    Oppe, Mark; Devlin, Nancy J; van Hout, Ben; Krabbe, Paul F M; de Charro, Frank

    2014-06-01

    To describe the research that has been undertaken by the EuroQol Group to improve current methods for health state valuation, to summarize the results of an extensive international pilot program, and to outline the key elements of the five-level EuroQol five-dimensional (EQ-5D-5L) questionnaire valuation protocol, which is the culmination of that work. To improve on methods of health state valuation for the EQ-5D-5L questionnaire, we investigated the performance of different variants of time trade-off and discrete choice tasks in a multinational setting. We also investigated the effect of three modes of administration on health state valuation: group interviews, online self-completion, and face-to-face interviews. The research program provided the basis for the EQ-5D-5L questionnaire valuation protocol. Two different types of tasks are included to derive preferences: a newly developed composite time trade-off task and a forced-choice paired comparisons discrete choice task. Furthermore, standardized blocked designs for the selection of the states to be valued by participants were created and implemented together with all other elements of the valuation protocol in a digital aid, the EuroQol Valuation Technology, which was developed in conjunction with the protocol. The EuroQol Group has developed a standard protocol, with accompanying digital aid and interviewer training materials, that can be used to create value sets for the EQ-5D-5L questionnaire. The use of a well-described, consistent protocol across all countries enhances the comparability of value sets between countries, and allows the exploration of the influence of cultural and other factors on health state values. Copyright © 2014 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  14. Population-Based Preference Weights for the EQ-5D Health States Using the Visual Analogue Scale (VAS) in Iran

    Science.gov (United States)

    Goudarzi, Reza; Zeraati, Hojjat; Akbari Sari, Ali; Rashidian, Arash; Mohammad, Kazem

    2016-01-01

    Background Health-related quality of life (HRQoL) is used as a measure to valuate healthcare interventions and guide policy making. The EuroQol EQ-5D is a widely used generic preference-based instrument to measure Health-related quality of life. Objectives The objective of this study was to develop a value set of the EQ-5D health states for an Iranian population. Patients and Methods This study is a cross-sectional study of Iranian populations. Our sample from Iranian populations consists out of 869 participants, who were selected for this study using a stratified probability sampling method. The sample was taken from individuals living in the city of Tehran and was stratified by age and gender from July to November 2013. Respondents valued 13 health states using the visual analogue scale (VAS) of the EQ-5D. Several fixed effects regression models were tested to predict the full set of health states. We selected the final model based on the logical consistency of the estimates, the sign and magnitude of the regression coefficients, goodness of fit, and parsimony. We also compared predicted values with a value set from similar studies in the UK and other countries. Results Our results show that the HRQoL does not vary among socioeconomic groups. Models at the individual level resulted in an additive model with all coefficients being statistically significant, R2 = 0.55, a value of 0.75 for the best health state (11112), and a value of -0.074 for the worst health state (33333). The value set obtained for the study sample remarkably differs from those elicited in developed countries. Conclusions This study is the first estimate for the EQ-5D value set based on the VAS in Iran. Given the importance of locally adapted value set the use of this value set can be recommended for future studies in Iran and In the EMRO regions. PMID:27186384

  15. A critical re-evaluation of the regression model specification in the US D1 EQ-5D value function.

    Science.gov (United States)

    Rand-Hendriksen, Kim; Augestad, Liv A; Dahl, Fredrik A

    2012-01-13

    The EQ-5D is a generic health-related quality of life instrument (five dimensions with three levels, 243 health states), used extensively in cost-utility/cost-effectiveness analyses. EQ-5D health states are assigned values on a scale anchored in perfect health (1) and death (0).The dominant procedure for defining values for EQ-5D health states involves regression modeling. These regression models have typically included a constant term, interpreted as the utility loss associated with any movement away from perfect health. The authors of the United States EQ-5D valuation study replaced this constant with a variable, D1, which corresponds to the number of impaired dimensions beyond the first. The aim of this study was to illustrate how the use of the D1 variable in place of a constant is problematic. We compared the original D1 regression model with a mathematically equivalent model with a constant term. Comparisons included implications for the magnitude and statistical significance of the coefficients, multicollinearity (variance inflation factors, or VIFs), number of calculation steps needed to determine tariff values, and consequences for tariff interpretation. Using the D1 variable in place of a constant shifted all dummy variable coefficients away from zero by the value of the constant, greatly increased the multicollinearity of the model (maximum VIF of 113.2 vs. 21.2), and increased the mean number of calculation steps required to determine health state values. Using the D1 variable in place of a constant constitutes an unnecessary complication of the model, obscures the fact that at least two of the main effect dummy variables are statistically nonsignificant, and complicates and biases interpretation of the tariff algorithm.

  16. The impact of losses in income due to ill health: does the EQ-5D reflect lost earnings?

    OpenAIRE

    Tilling, C.; Krol, M.; Tsuchiya, A; Brazier, J; Van Exel, J; Brouwer, W.

    2009-01-01

    Two key questions in the context of UK health policy are: do the published preference indices for EQ-5D reflect the impact of lost earnings? Are we currently implicitly including indirect costs in our analyses? It is crucial to investigate whether or not individuals take into account any possible impact of lost income in health state valuation exercises. If respondents do consider income effects, and these considerations change valuations, then these effects would need to be excluded both und...

  17. Usefulness of EQ-5D in Assessing Health Status in Primary Care Patients with Major Depressive Disorder

    Directory of Open Access Journals (Sweden)

    Nowicki Marie-Laure

    2004-05-01

    Full Text Available Abstract Objectives Major depressive disorder (MDD is a prevalent psychiatric disorder associated with impaired patient functioning and reductions in health-related quality of life (HRQL. The present study describes the impact of MDD on patients' HRQL and examines preference-based health state differences by patient features and clinical characteristics. Methods 95 French primary care practitioners recruited 250 patients with a DSM-IV diagnosis of MDD for inclusion in an eight-week follow-up cohort. Patient assessments included the Montgomery Asberg Depression Rating Scale (MADRS, the Clinical Global Impression of Severity (CGI, the Short Form-36 Item scale (SF-36, the Quality of Life Depression Scale (QLDS and the EuroQoL (EQ-5D. Results The mean EQ-5D utility at baseline was 0.33, and 8% of patients rated their health state as worse than death. There were no statistically significant differences in utilities by demographic features. Significant differences were found in mean utilities by level of disease severity assessed by CGI. The different clinical response profiles, assessed by MADRS, were also revealed by EQ-5D at endpoint: 0.85 for responders remitters, 0.72 for responders non-remitter, and 0.58 for non-responders. Even if HRQL and EQ-5D were moderately correlated, they shared only 40% of variance between baseline and endpoint. Conclusions Self-reported patient valuations for depression are important patient-reported outcomes for cost-effectiveness evaluations of new antidepressant compounds and help in further understanding patient compliance with antidepressant treatment.

  18. Enrichment of light hydrocarbon mixture

    Science.gov (United States)

    Yang, Dali [Los Alamos, NM; Devlin, David [Santa Fe, NM; Barbero, Robert S [Santa Cruz, NM; Carrera, Martin E [Naperville, IL; Colling, Craig W [Warrenville, IL

    2011-11-29

    Light hydrocarbon enrichment is accomplished using a vertically oriented distillation column having a plurality of vertically oriented, nonselective micro/mesoporous hollow fibers. Vapor having, for example, both propylene and propane is sent upward through the distillation column in between the hollow fibers. Vapor exits neat the top of the column and is condensed to form a liquid phase that is directed back downward through the lumen of the hollow fibers. As vapor continues to ascend and liquid continues to countercurrently descend, the liquid at the bottom of the column becomes enriched in a higher boiling point, light hydrocarbon (propane, for example) and the vapor at the top becomes enriched in a lower boiling point light hydrocarbon (propylene, for example). The hollow fiber becomes wetted with liquid during the process.

  19. Visual and health outcomes, measured with the activity inventory and the EQ-5D, in visual impairment.

    Science.gov (United States)

    Macedo, Antonio Filipe; Ramos, Pedro Lima; Hernandez-Moreno, Laura; Cima, Joana; Baptista, António M G; Marques, Ana Patricia; Massof, Robert; Santana, Rui

    2017-03-30

    Generic instruments to assess health utilities can be used to express the burden of health problems in widely used indexes. That is in contrast with what can be obtained with condition-specific instruments, outcomes are very specific and difficult to compare across conditions. The purpose of this study was to assess health and visual outcomes and its determinants in patients with visual impairment (VI) using the EQ-5D-3L and the Activity Inventory (AI). Participants were recruited in different hospitals during the PCVIP-study. A total of 134 patients with acuity 0.30 logMAR or less in the better eye were interviewed. The AI includes 46 goals split between three objectives: social functioning, recreation and daily living, and was used to measure visual ability. The EQ-5D consists of five questions covering one domain each and was used to provide a measure of health states. Responses to each domain were combined to produce a single individual index. The AI and the EQ-5D-3L showed enough discriminatory power between VI levels (p visual ability were level of VI in better eye, age and gender, R(2)  = 0.43, (p visual ability. © 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  20. The "no problems"-problem: an empirical analysis of ceiling effects on the EQ-5D 5L.

    Science.gov (United States)

    Konnopka, Alexander; Koenig, Hans-Helmut

    2017-08-01

    To analyze the association between ceiling effects on the EQ-5D 5L and morbidity in a general population sample. We used a cross-sectional sample of the German general population (n = 5007) to describe the frequency of health state "11111" and "no problems"-answers on the five single dimensions stratified by the number of diseases for which participants utilized health care during the last 6 months. For the five single dimensions we also used specific criteria to analyze their discriminative ability. A logit-model was applied for a multivariate analysis of ceiling effects. 31% of participants reported the health state "11111." This percentage strongly decreased with increasing morbidity, down to 4.9% if four or more diseases were present. The dimensions "mobility," "usual activities," and "pain/discomfort" showed good discriminative abilities. The dimensions "anxiety/depression" and "self -care" were able to discriminate between different levels of morbidity, but nevertheless showed strong ceiling effects, in particular "self-care." When analyzing ceiling effects of the EQ-5D 5L, one has to draw attention to morbidity since high proportions of participants indicating the best health state might result from being healthy regarding the dimensions assessed by the EQ-5D, in particular in general population datasets.

  1. How people with multiple sclerosis rate their quality of life: an EQ-5D survey via the UK MS register.

    Science.gov (United States)

    Jones, Kerina H; Ford, David V; Jones, Philip A; John, Ann; Middleton, Rodden M; Lockhart-Jones, Hazel; Peng, Jeffrey; Osborne, Lisa A; Noble, J Gareth

    2013-01-01

    The EQ-5D is a widely-used, standardised, quality of life measure producing health profiles, indices and states. The aims of this study were to assess the role of various factors in how people with Multiple Sclerosis rate their quality of life, based on responses to the EQ-5D received via the web portal of the UK MS Register. The 4516 responses to the EQ-5D (between May 2011 and April 2012) were collated with basic demographic and descriptive MS data and the resulting dataset was analysed in SPSS (v.20). The mean health state for people with MS was 59.73 (SD 22.4, median 61), compared to the UK population mean of 82.48 (which is approximately 1SD above the cohort mean). The characteristics of respondents with high health states (at or above +1SD) were: better health profiles (most predictive dimension: Usual Activities), higher health indices, younger age, shorter durations of MS, female gender, relapsing-remitting MS, higher educational attainment and being in paid employment (all p-valuesemployment status of sick/disabled (p = 0.0014 for age, all other p-valuesrate their quality of life, and it provides new knowledge on the various factors that contribute to their self-assessed health status. These findings demonstrate the impact of MS on quality of life, and they can be used to inform care provision and further research, to work towards enhancing the quality of life of people with MS.

  2. Fuento: functional enrichment for bioinformatics.

    Science.gov (United States)

    Weichselbaum, David; Zagrovic, Bojan; Polyansky, Anton A

    2017-08-15

    The currently available functional enrichment software focuses mostly on gene expression analysis, whereby server- and graphical-user-interface-based tools with specific scope dominate the field. Here we present an efficient, user-friendly, multifunctional command-line-based functional enrichment tool (fu-en-to), tailored for the bioinformatics researcher. Source code and binaries freely available for download at github.com/DavidWeichselbaum/fuento, implemented in C ++ and supported on Linux and OS X. newant@gmail.com or bojan.zagrovic@univie.ac.at.

  3. Effect of a single dialysis session on cognitive function in CKD5D patients: a prospective clinical study.

    Science.gov (United States)

    Schneider, Sabrina M; Malecki, Anne K; Müller, Katrin; Schönfeld, Robby; Girndt, Matthias; Mohr, Peter; Hiss, Marcus; Kielstein, Heike; Jäger, Kristin; Kielstein, Jan T

    2015-09-01

    Cognitive function declines in parallel to the decrease in glomerular filtration rate, best epitomized by the markedly reduced cerebral performance in patients undergoing maintenance haemodialysis [chronic kidney disease stage 5 dialysis (CKD5D)]. Aside from structural permanent damage, there seems to be a reversible part of low cognitive performance. The potential effect of a single dialysis session on cognitive function remains still elusive. The aim of the study was to assess cognitive function using a widespread test battery and avoiding excluding effects of circadian variations. Twenty-eight medically stable CKD5D patients (age: 54.9 ± 13.2 years, dialysis vintage: 46.2 ± 51.0 month) at two tertiary care centres with outpatient dialysis units were enrolled. Cognitive testing was always performed twice within 24 h, 1 h prior to haemodialysis (T1pre-dialysis) as well as 19 h after the end of dialysis (T2post-dialysis) including assessment of memory, attention and concentration, executive functioning, word fluency and psychomotor speed by using a well-validated neuropsychological test battery. Patients were randomized into two groups. One group was examined before (T1pre-dialysis) and after (T2post-dialysis) Dialysis Session 1. The other group was first examined the day after Dialysis Session 1 (T2post-dialysis) and then before Dialysis Session 2 (T1pre-dialysis) in order to exclude potential learning effects. Twenty age-matched subjects with normal excretory renal function were used for comparison. Neuropsychological testing found that the CKD5D performed significantly worse on measures of alertness, attention, working memory, logical and visual memory, word fluency and executive functions compared with non-CKD subjects. No differences in short-term memory, selective attention, as well as problem-solving and planning were found between CKD5D patients and non-CKD subjects. A single haemodialysis session led to a significant improvement in logical (Rivermead

  4. Coronary artery calcification in CKD-5D patients is tied to adverse cardiac function and increased mortality

    Science.gov (United States)

    Anaya, Paul; Blomquist, Gustav A.; Davenport, Daniel L.; Monier-Faugere, Marie-Claude; Sorrell, Vincent L.; Malluche, Hartmut H.

    2016-01-01

    Background: Coronary artery calcification (CAC) is common in patients with chronic kidney disease on hemodialysis (CKD-5D) and is an important predictor of mortality. However, cardiac functional links between CAC and mortality have not been well established. This study tested the hypothesis that CAC increases mortality by adversely affecting cardiac function. Methods: Patients were recruited from 37 regional dialysis centers. 2-D and Doppler echocardiographic analyses were performed, and CAC was measured using 64-slice computed tomography. Relationships between CAC and echocardiographic measures of left ventricular (LV) function were analyzed. Survival was assessed with median follow-up of 37 months. Results: There were 157 patients: 59% male, 46% Caucasian, 48% diabetic. Median age was 55 years, and median duration of CKD-5D was 45 months. Agatston CAC scores > 100 were found in 69% of patients, with 51% having a score > 400. CAC was associated with measures of LV systolic and diastolic function (global longitudinal strain (GLS; rho = 0.270, p = 0.004)), peak LV systolic velocity (rho = –0.259, p = 0.004), and estimate of LV filling pressure (E:E’; rho = 0.286, p = 0.001). Multivariate regression confirmed these relationships after adjustment for age, gender, LV ejection fraction, and coronary artery disease. Valvular calcification varied linearly with CAC (p diastolic and systolic functional measures were significant predictors of mortality, the strongest of which was LV diastolic dysfunction. Conclusions: These findings show a link between CAC, cardiac function, and mortality in CKD-5D. LV diastolic function (E:E’), peak LV systolic velocity, and GLS are independent predictors of mortality. Valvular calcification may be an important marker of CAC in CKD-5D. These effects on cardiac function likely explain the high mortality with CKD-5D and describe a potentially-valuable role for echocardiography in the routine management of these patients

  5. Instrument-Defined Estimates of the Minimally Important Difference for EQ-5D-5L Index Scores.

    Science.gov (United States)

    McClure, Nathan S; Sayah, Fatima Al; Xie, Feng; Luo, Nan; Johnson, Jeffrey A

    2017-04-01

    The five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) is a preference-based measure of health-related quality of life (HRQOL), which yields an index score anchored at 0 (dead) and 1 (full health). We lack evidence on estimates for the minimally important difference (MID) of the EQ-5D-5L that will help in interpreting differences or changes in HRQOL measured by this scale score. To estimate the MID of the EQ-5D-5L index score for available scoring algorithms including algorithms from Canada, China, Spain, Japan, England, and Uruguay. A simulation-based approach based on instrument-defined single-level transitions was used to estimate the MID values of the EQ-5D-5L for each country-specific scoring algorithm. The simulation-based instrument-defined MID estimates (mean ± SD) for each country-specific scoring algorithm were as follows: Canada, 0.056 ± 0.011; China, 0.069 ± 0.007; Spain, 0.061 ± 0.008; Japan, 0.048 ± 0.004; England, 0.063 ± 0.013; and Uruguay, 0.063 ± 0.019. Differences in MID estimates reflect differences in population preferences, in valuation techniques used, as well as in modeling strategies. After excluding the maximum-valued scoring parameters, the MID estimates (mean ± SD) were as follows: Canada, 0.037 ± 0.001; China, 0.058 ± 0.005; Spain, 0.045 ± 0.009; Japan, 0.044 ± 0.004; England, 0.037 ± 0.008; and Uruguay, 0.040 ± 0.010. Simulation-based estimates of the MID of the EQ-5D-5L index score were generally between 0.037 and 0.069, which are similar to the MID estimates of other preference-based HRQOL measures. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  6. Spin-selective measurement of the unoccupied density of 5d-states of EuO by resonant inelastic X-ray scattering (RIXS)

    CERN Document Server

    Wittkop, C

    2000-01-01

    In the framework of this thesis it was successfully shown that a spin- selective measurement of the unoccupied density od states by means of resonant inelastic X-ray scattering is possible. Especially for this studies were performed on the unoccupied 5d conduction band of EuO. As essential results it can be stated that a temperature- dependent shift of the 5d arrow up to the 5d arrow down density of states is present.

  7. Enrichment proteomics challenges and perspectives

    NARCIS (Netherlands)

    Song, Wei

    2016-01-01

    This thesis is based on two technology projects from the Centre for BioSystems Genomics (CBSG), entitled ‘Comparative proteomics on Plant Pathogen interactions through enrichment of the N-glycoproteome and tagged-glycoproteome’ (TD7) and ‘Plasma Membrane proteomics for Plant

  8. Meadow enriched ACP process algebras

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2009-01-01

    We introduce the notion of an ACP process algebra. The models of the axiom system ACP are the origin of this notion. ACP process algebras have to do with processes in which no data are involved. We also introduce the notion of a meadow enriched ACP process algebra, which is a simple generalization

  9. Lanthanum carbonate for the treatment of hyperphosphatemia in CKD 5D: multicenter, double blind, randomized, controlled trial in mainland China

    Directory of Open Access Journals (Sweden)

    Xu Jing

    2013-02-01

    Full Text Available Abstract Background Serum phosphorus control is critical for chronic kidney disease (CKD 5D patients. Currently, clinical profile for an oral phosphorus binder in the mainland Chinese population is not available. Objective To establish the efficacy, safety, and tolerability of lanthanum carbonate in CKD 5D patients. Design Multicenter, randomized, double blind, placebo-controlled study. A central randomization center used computer generated tables to allocate treatments. Setting Twelve tertiary teaching hospitals and medical university affiliated hospitals in mainland China. Participants Overall, 258 hemodialysis or continuous ambulatory peritoneal dialysis (CAPD adult patients were enrolled. Intervention After a 0–3-week washout period and a 4-week lanthanum carbonate dose-titration period, 230 patients were randomized 1:1 to receive lanthanum carbonate (1500 mg-3000 mg or placebo for a further 4-week maintenance phase. Main outcome measures Efficacy and safety of lanthanum carbonate to achieve and maintain target serum phosphorus concentrations were assessed. Results In the titration phase, serum phosphorus concentrations of all patients decreased significantly. About three-fifths achieved target levels without significantly disturbing serum calcium levels. At the end of the maintenance period, the mean difference in serum phosphorus was significantly different between the lanthanum carbonate and placebo-treated groups (0.63±0.62 mmol/L vs. 0.15±0.52 mmol/L, P Conclusion Lanthanum carbonate is an efficacious and well-tolerated oral phosphate binder with a mild AE profile in hemodialysis and CAPD patients. This agent may provide an alternative for the treatment of hyperphosphatemia in CKD 5D patients in mainland China. Trial registration No. ChiCTR-TRC-10000817

  10. Reconnection and particle acceleration in interacting flux ropes - I. Magnetohydrodynamics and test particles in 2.5D

    Science.gov (United States)

    Ripperda, B.; Porth, O.; Xia, C.; Keppens, R.

    2017-05-01

    Magnetic reconnection and non-thermal particle distributions associated with current-driven instabilities are investigated by means of resistive magnetohydrodynamics (MHD) simulations combined with relativistic test particle methods. We propose a system with two parallel, repelling current channels in an initially force-free equilibrium, as a simplified representation of flux ropes in a stellar magnetosphere. The current channels undergo a rotation and separation on Alfvénic time-scales, forming secondary islands and (up to tearing unstable) current sheets in which non-thermal energy distributions are expected to develop. Using the recently developed particle module of our open-source grid-adaptive mpi-amrvac software, we simulate MHD evolution combined with test particle treatments in MHD snapshots. We explore under which plasma-β conditions the fastest reconnection occurs in 2.5D scenarios, and in these settings, test particles are evolved. We quantify energy distributions, acceleration mechanisms, relativistic corrections to the particle equations of motion and effects of resistivity in magnetically dominated proton-electron plasmas. Due to large resistive electric fields and indefinite acceleration of particles in the infinitely long current channels, hard energy spectra are found in 2.5D configurations. Solutions to these numerical artefacts are proposed for both 2.5D setups and future 3D work. We discuss the MHD of an additional kink instability in 3D setups and the expected effects on energy distributions. The obtained results hold as a proof-of-principle for test particle approaches in MHD simulations, relevant to explore less idealized scenarios like solar flares and more exotic astrophysical phenomena, like black hole flares, magnetar magnetospheres and pulsar wind nebulae.

  11. Charged vector particle tunneling from a pair of accelerating and rotating and 5D gauged super-gravity black holes

    Energy Technology Data Exchange (ETDEWEB)

    Javed, Wajiha; Ali, Riasat [University of Education, Division of Science and Technology, Lahore (Pakistan); Abbas, G. [The Islamia University of Bahawalpur, Department of Mathematics, Bahawalpur (Pakistan)

    2017-05-15

    The aim of this paper is to study the quantum tunneling process for charged vector particles through the horizons of more generalized black holes by using the Proca equation. For this purpose, we consider a pair of charged accelerating and rotating black holes with Newman-Unti-Tamburino parameter and a black hole in 5D gauged super-gravity theory, respectively. Further, we study the tunneling probability and corresponding Hawking temperature for both black holes by using the WKB approximation. We find that our analysis is independent of the particles species whether or not the background black hole geometries are more generalized. (orig.)

  12. High-efficiency ({eta} = 39.6%, AM 1.5D) cascade of photoconverters in solar splitting systems

    Energy Technology Data Exchange (ETDEWEB)

    Khvostikov, V. P., E-mail: vlkhv@scell.ioffe.ru; Vlasov, A. S.; Sorokina, S. V.; Potapovich, N. S.; Timoshina, N. Kh.; Shvarts, M. Z.; Andreev, V. M. [Russian Academy of Sciences, Ioffe Physical Technical Institute (Russian Federation)

    2011-06-15

    A concentrator photovoltaic module with spectral splitting of solar radiation is developed. The module is based on a Fresnel lens and two dichroic filters. Solar cells based on AlGaAs and GaAs are grown by low-temperature liquid-phase epitaxy. GaSb photoconverters are fabricated by zinc gas-phase diffusion into a base epitaxial layer or an n-type GaSb substrate. The total efficiency of three solar cells developed for the spectral splitting module reached 39.6% (AM 1.5D spectrum).

  13. Fiber resources

    Science.gov (United States)

    P. J. Ince

    2004-01-01

    In economics, primary inputs or factors of production define the term ‘resources.’ Resources include land resources (plants, animals, and minerals), labor, capital, and entrepreneurship. Almost all pulp and paper fiber resources are plant materials obtained from trees or agricultural crops. These resources encompass plant materials harvested directly from the land (...

  14. A New Fate of a Warped 5D FRW Model with a U(1) Scalar Gauge Field

    CERN Document Server

    Slagter, Reinoud Jan

    2015-01-01

    If we live on the weak brane with zero effective cosmological constant in a warped 5D bulk spacetime , gravitational waves and brane fluctuations can be generated by a part of the 5D Weyl tensor and carries information of the gravitational field outside the brane. We consider on a cylindrical symmetric warped FRW background the U(1) self-gravitating scalar-gauge field without bulk matter. It turns out that "branons" can be formed dynamically, due to the modified energy-momentum tensor components of the cosmic string. As a result, we find that the late-time behavior could be significant deviate from the standard evolution of the universe. The effect is triggered by the time-dependent warp factor, of the form $\\sqrt{ae^{\\tau t}+be^{-\\tau t}}$ and the modified brane equations, comparable with a dark energy effect. This is a brane-world mechanism, not present is standard 4D FRW, where the large disturbances are rapidly damped as the expansion proceed. Because gravity can propagate in the bulk, the cosmic string c...

  15. A 2.5D Map-Based Mobile Robot Localization via Cooperation of Aerial and Ground Robots.

    Science.gov (United States)

    Nam, Tae Hyeon; Shim, Jae Hong; Cho, Young Im

    2017-11-25

    Recently, there has been increasing interest in studying the task coordination of aerial and ground robots. When a robot begins navigation in an unknown area, it has no information about the surrounding environment. Accordingly, for robots to perform tasks based on location information, they need a simultaneous localization and mapping (SLAM) process that uses sensor information to draw a map of the environment, while simultaneously estimating the current location of the robot on the map. This paper aims to present a localization method based in cooperation between aerial and ground robots in an indoor environment. The proposed method allows a ground robot to reach accurate destination by using a 2.5D elevation map built by a low-cost RGB-D (Red Green and Blue-Depth) sensor and 2D Laser sensor attached onto an aerial robot. A 2.5D elevation map is formed by projecting height information of an obstacle using depth information obtained by the RGB-D sensor onto a grid map, which is generated by using the 2D Laser sensor and scan matching. Experimental results demonstrate the effectiveness of the proposed method for its accuracy in location recognition and computing speed.

  16. A 2.5D Map-Based Mobile Robot Localization via Cooperation of Aerial and Ground Robots

    Directory of Open Access Journals (Sweden)

    Tae Hyeon Nam

    2017-11-01

    Full Text Available Recently, there has been increasing interest in studying the task coordination of aerial and ground robots. When a robot begins navigation in an unknown area, it has no information about the surrounding environment. Accordingly, for robots to perform tasks based on location information, they need a simultaneous localization and mapping (SLAM process that uses sensor information to draw a map of the environment, while simultaneously estimating the current location of the robot on the map. This paper aims to present a localization method based in cooperation between aerial and ground robots in an indoor environment. The proposed method allows a ground robot to reach accurate destination by using a 2.5D elevation map built by a low-cost RGB-D (Red Green and Blue-Depth sensor and 2D Laser sensor attached onto an aerial robot. A 2.5D elevation map is formed by projecting height information of an obstacle using depth information obtained by the RGB-D sensor onto a grid map, which is generated by using the 2D Laser sensor and scan matching. Experimental results demonstrate the effectiveness of the proposed method for its accuracy in location recognition and computing speed.

  17. Application of the perfectly matched layer in 2.5D marine controlled-source electromagnetic modeling

    Science.gov (United States)

    Li, Gang; Han, Bo

    2017-09-01

    For the traditional framework of EM modeling algorithms, the Dirichlet boundary is usually used which assumes the field values are zero at the boundaries. This crude condition requires that the boundaries should be sufficiently far away from the area of interest. Although cell sizes could become larger toward the boundaries as electromagnetic wave is propagated diffusively, a large modeling area may still be necessary to mitigate the boundary artifacts. In this paper, the complex frequency-shifted perfectly matched layer (CFS-PML) in stretching Cartesian coordinates is successfully applied to 2.5D frequency-domain marine controlled-source electromagnetic (CSEM) field modeling. By using this PML boundary, one can restrict the modeling area of interest to the target region. Only a few absorbing layers surrounding the computational area can effectively depress the artificial boundary effect without losing the numerical accuracy. A 2.5D marine CSEM modeling scheme with the CFS-PML is developed by using the staggered finite-difference discretization. This modeling algorithm using the CFS-PML is of high accuracy, and shows advantages in computational time and memory saving than that using the Dirichlet boundary. For 3D problem, this computation time and memory saving should be more significant.

  18. Research of Non-linear 2.5D Fluid-structure Interaction Model of Gravity Dam

    Science.gov (United States)

    Li, Yiran; Xu, Menghua; Sun, Hao

    2017-10-01

    Aseismic safety of dam involves people’s lives and properties, even has a great impact on national economic development. The key to this project is to have a fairly complete fluid-structure interaction (FSI) theory and a calculation method with a good accuracy. Therefore, focused on the FSI dynamic problem of gravity dam under seismic action, this paper presented the non-linear 2.5D dynamic theoretical model of concrete gravity dam established by segmenting fluid model and numerical solution method, compared the numerical simulation result under preliminary gravity action with 3D model. The study showed that the 2.5D dynamic calculation model could well reflect the seismic dynamic FSI behavior and effect of concrete gravity dam in the respects of displacement and stress and benefited the large-scale non-linear 3D aseismic calculation of gravity dam because of the effective reduction of 3D FSI numerical calculation time, which improved the calculation efficiency.

  19. Refraction-based 2D, 2.5D and 3D medical imaging: Stepping forward to a clinical trial

    Energy Technology Data Exchange (ETDEWEB)

    Ando, Masami [Tokyo University of Science, Research Institute for Science and Technology, Noda, Chiba 278-8510 (Japan)], E-mail: msm-ando@rs.noda.tus.ac.jp; Bando, Hiroko [Tsukuba University (Japan); Tokiko, Endo; Ichihara, Shu [Nagoya Medical Center (Japan); Hashimoto, Eiko [GUAS (Japan); Hyodo, Kazuyuki [KEK (Japan); Kunisada, Toshiyuki [Okayama University (Japan); Li Gang [BSRF (China); Maksimenko, Anton [Tokyo University of Science, Research Institute for Science and Technology, Noda, Chiba 278-8510 (Japan); KEK (Japan); Mori, Kensaku [Nagoya University (Japan); Shimao, Daisuke [IPU (Japan); Sugiyama, Hiroshi [KEK (Japan); Yuasa, Tetsuya [Yamagata University (Japan); Ueno, Ei [Tsukuba University (Japan)

    2008-12-15

    An attempt at refraction-based 2D, 2.5D and 3D X-ray imaging of articular cartilage and breast carcinoma is reported. We are developing very high contrast X-ray 2D imaging with XDFI (X-ray dark-field imaging), X-ray CT whose data are acquired by DEI (diffraction-enhanced imaging) and tomosynthesis due to refraction contrast. 2D and 2.5D images were taken with nuclear plates or with X-ray films. Microcalcification of breast cancer and articular cartilage are clearly visible. 3D data were taken with an X-ray sensitive CCD camera. The 3D image was successfully reconstructed by the use of an algorithm newly made by our group. This shows a distinctive internal structure of a ductus lactiferi (milk duct) that contains inner wall, intraductal carcinoma and multifocal calcification in the necrotic core of the continuous DCIS (ductal carcinoma in situ). Furthermore consideration of clinical applications of these contrasts made us to try tomosynthesis. This attempt was satisfactory from the view point of articular cartilage image quality and the skin radiation dose.

  20. EQ-5D-5L in the General German Population: Comparison and Evaluation of Three Yearly Cross-Section Surveys

    Directory of Open Access Journals (Sweden)

    Manuel B. Huber

    2016-03-01

    Full Text Available Health-related quality of life (HRQoL is a key measure for evaluating health status in populations. Using the recent EQ-5D-5L for measurement, this study analyzed quality of life results and their stability over consecutive population surveys. Three cross-section surveys for representative samples of the general German population from 2012, 2013, and 2014 were evaluated using the EQ-5D-5L descriptive system and valuation by the Visual Analog Scale (VAS. Aggregated sample size reached 6074. The dimension with the highest prevalence of problems was pain/discomfort (31.7%. Compared with 2012 (59.3%, the percentage of participants in the best health state increased slightly in 2013 (63.4% and 2014 (62%. Over the 3-year period, diabetes and heart disease had the strongest negative influence on mean VAS result. The number of reported chronic diseases cumulatively reduced mean VAS. Extreme problems in one or more dimensions were stated by only 0.1%–0.2% of patients. Of the potential 247 health states with a problem score ≥20, only six were observed in the aggregated sample. HRQoL results were fairly stable over the 3 years, but the share of the population with no problems was not. Results from the aggregated sample may serve as updated reference values for the general German population.

  1. Role of electron filling in the magnetic anisotropy of monolayer WSe2 doped with 5 d transition metals

    Science.gov (United States)

    Song, Yan; Wang, Xiaocha; Mi, Wenbo

    2017-12-01

    Exploring magnetic anisotropy (MA) in single-atom-doped two-dimensional materials provides a viable ground for realizing information storage and processing at ultimate length scales. Herein, the MA of 5 d transition-metal doped monolayer WSe2 is investigated by first-principles calculations. Large MA energy (MAE) is achieved in several doping systems. The direction of MA is determined by the dopant in-plane d states in the vicinity of the Fermi level in line with previous studies. An occupation rule that the parity of the occupation number of the in-plane d orbital of the dopant determines the preference between in-plane and out-of-plane anisotropy is found in this 5 d -doped system. Furthermore, this rule is understood by second-order perturbation theory and proved by charge-doping analysis. Considering relatively little research on two-dimensional MA and not sufficiently large MAE, suitable contact medium dopant pairs with large MAE and tunable MA pave the way to novel data storage paradigms.

  2. The validity of the EQ-5D-3L items: An investigation with type 2 diabetes patients from six European countries

    NARCIS (Netherlands)

    U. Konerding (Uwe); S.G. Elkhuizen (Sylvia G.); R. Faubel (Raquel); P. Forte (Paul); T. Malmström (Tomi); E. Pavi (Elpida); M.F. Janssen (Bas)

    2014-01-01

    textabstractBackground: Most previous studies concerning the validity of the EQ-5D-3L items refer to applications of only a single language version of the EQ-5D-3L in only one country. Therefore, there is little information concerning the extent to which the results can be generalised across

  3. 4f-5d Transitions of Tb3+ in Cs2NaYF6: The Effect of Distortion of the Excited-State Configuration

    NARCIS (Netherlands)

    Duan, C.K.; Tanner, P.A.; Meijerink, A.; Makhov, V.

    2011-01-01

    The low-temperature absorption and excitation spectra of interconfigurational 4f–5d transitions of Tb3+ in a cubic fluoride host demonstrate the appearance of a first-order linear Jahn–Teller effect for the high-spin excited states of the excited electronic configuration 4f75d involving 5d t2g

  4. Thermal ionization and thermally activated crossover quenching processes for 5d-4f luminescence in Y3 A l5-x G ax O12 : P r3+

    NARCIS (Netherlands)

    Ueda, J.; Meijerink, Andries; Dorenbos, P.; Bos, A.J.J.; Tanabe, Setsuhisa

    2017-01-01

    We investigated thermally activated ionization and thermally activated crossover as the two possibilities of quenching of 5d luminescence in Pr3+-doped Y3Al5-xGaxO12. Varying the Ga content x gives the control over the relative energy level location of the 5d and 4f2:PJ3 states of Pr3+ and the

  5. The measurement of long-term health-related quality of life after injury: comparison of EQ-5D and the health utilities index

    NARCIS (Netherlands)

    Polinder, Suzanne; Haagsma, Juanita A.; Bonsel, Gouke; Essink-Bot, Marie-Louise; Toet, Hidde; van Beeck, Ed F.

    2010-01-01

    Objective Empirical head-to-head comparison of the health utility index (HUI) mark 2 and 3 and the EuroQol-5D (EQ-5D) in injury patients of all severity levels to obtain more insight into the strengths and limitations of the multi-attribute utility measures (MAUI) to estimate utility losses in

  6. Selenium Enrichment of Horticultural Crops

    Directory of Open Access Journals (Sweden)

    Martina Puccinelli

    2017-06-01

    Full Text Available The ability of some crops to accumulate selenium (Se is crucial for human nutrition and health. Selenium has been identified as a cofactor of the enzyme glutathione peroxidase, which is a catalyzer in the reduction of peroxides that can damage cells and tissues, and can act as an antioxidant. Plants are the first link in the food chain, which ends with humans. Increasing the Se quantity in plant products, including leafy and fruity vegetables, and fruit crops, without exceeding the toxic threshold, is thus a good way to increase animal and human Se intake, with positive effects on long-term health. In many Se-enriched plants, most Se is in its major organic form. Given that this form is more available to humans and more efficient in increasing the selenium content than inorganic forms, the consumption of Se-enriched plants appears to be beneficial. An antioxidant effect of Se has been detected in Se-enriched vegetables and fruit crops due to an improved antioxidative status and to a reduced biosynthesis of ethylene, which is the hormone with a primary role in plant senescence and fruit ripening. This thus highlights the possible positive effect of Se in preserving a longer shelf-life and longer-lasting quality.

  7. Selenium Enrichment of Horticultural Crops.

    Science.gov (United States)

    Puccinelli, Martina; Malorgio, Fernando; Pezzarossa, Beatrice

    2017-06-04

    The ability of some crops to accumulate selenium (Se) is crucial for human nutrition and health. Selenium has been identified as a cofactor of the enzyme glutathione peroxidase, which is a catalyzer in the reduction of peroxides that can damage cells and tissues, and can act as an antioxidant. Plants are the first link in the food chain, which ends with humans. Increasing the Se quantity in plant products, including leafy and fruity vegetables, and fruit crops, without exceeding the toxic threshold, is thus a good way to increase animal and human Se intake, with positive effects on long-term health. In many Se-enriched plants, most Se is in its major organic form. Given that this form is more available to humans and more efficient in increasing the selenium content than inorganic forms, the consumption of Se-enriched plants appears to be beneficial. An antioxidant effect of Se has been detected in Se-enriched vegetables and fruit crops due to an improved antioxidative status and to a reduced biosynthesis of ethylene, which is the hormone with a primary role in plant senescence and fruit ripening. This thus highlights the possible positive effect of Se in preserving a longer shelf-life and longer-lasting quality.

  8. Network-based functional enrichment

    Directory of Open Access Journals (Sweden)

    Poirel Christopher L

    2011-11-01

    Full Text Available Abstract Background Many methods have been developed to infer and reason about molecular interaction networks. These approaches often yield networks with hundreds or thousands of nodes and up to an order of magnitude more edges. It is often desirable to summarize the biological information in such networks. A very common approach is to use gene function enrichment analysis for this task. A major drawback of this method is that it ignores information about the edges in the network being analyzed, i.e., it treats the network simply as a set of genes. In this paper, we introduce a novel method for functional enrichment that explicitly takes network interactions into account. Results Our approach naturally generalizes Fisher’s exact test, a gene set-based technique. Given a function of interest, we compute the subgraph of the network induced by genes annotated to this function. We use the sequence of sizes of the connected components of this sub-network to estimate its connectivity. We estimate the statistical significance of the connectivity empirically by a permutation test. We present three applications of our method: i determine which functions are enriched in a given network, ii given a network and an interesting sub-network of genes within that network, determine which functions are enriched in the sub-network, and iii given two networks, determine the functions for which the connectivity improves when we merge the second network into the first. Through these applications, we show that our approach is a natural alternative to network clustering algorithms. Conclusions We presented a novel approach to functional enrichment that takes into account the pairwise relationships among genes annotated by a particular function. Each of the three applications discovers highly relevant functions. We used our methods to study biological data from three different organisms. Our results demonstrate the wide applicability of our methods. Our algorithms are

  9. The impact of a revised EQ-5D population scoring on preference-based utility scores in an inflammatory arthritis cohort.

    LENUS (Irish Health Repository)

    Adams, Roisin

    2012-02-01

    BACKGROUND AND OBJECTIVE: It is well established that there are problems with the EQ-5D. This is due to the original scoring methods used and how negative time trade-off (TTO) values were treated. A revised scoring method has been published. This article applies this to an inflammatory arthritis cohort. The objective is to examine the impact of a revised scoring system for the EQ-5D (UK) TTO on the utility estimates and in the case of rheumatoid arthritis, to explore the impact of using different utility metrics on the incremental cost-effectiveness ratio (ICER) results of an economic model. METHODS: A total of 504 patients with inflammatory arthritis were rescored using revised EQ-5D scoring, which uses an episodic random utility model to deal with negative TTO values. Differences in utility scores were compared and the new mapping coefficients were obtained. These were then used in an economic model to examine the impact on the ICER. RESULTS: In rheumatoid arthritis, the overall change is less for the revised EQ-5D scoring than with the original EQ-5D (TTO) but greater than the SF-6D: EQ-5D UK -0.22 (95% confidence interval [CI] -0.30 to -0.15), revised EQ-5D UK -0.16 (95% CI -0.21 to -0.10) and SF-6D -0.08 (95% CI -0.11 to -0.05). A similar trend is seen in the psoriatic arthritis group. The economic model produced different ICERs, when different utility measures were used; EQ-5D (TTO) euro42,402, SF-6D euro111,788, and revised EQ-5D (TTO) euro57,747. CONCLUSION: In the context of inflammatory arthritis, this article demonstrates that a revised scoring for EQ-5D may have a significant impact on utility estimates and on the output of the economic model.

  10. Defining the needs for gas centrifuge enrichment plants advanced safeguards

    Energy Technology Data Exchange (ETDEWEB)

    Boyer, Brian David [Los Alamos National Laboratory; Erpenbeck, Heather H [Los Alamos National Laboratory; Miller, Karen A [Los Alamos National Laboratory; Swinhoe, Martyn T [Los Alamos National Laboratory; Ianakiev, Kiril [Los Alamos National Laboratory; Marlow, Johnna B [Los Alamos National Laboratory

    2010-04-05

    Current safeguards approaches used by the International Atomic Energy Agency (IAEA) at gas centrifuge enrichment plants (GCEPs) need enhancement in order to verify declared low-enriched (LEU) production, detect undeclared LEU production and detect highly enriched uranium (HEU) production with adequate detection probability using nondestructive assay (NDA) techniques. At present inspectors use attended systems, systems needing the presence of an inspector for operation, during inspections to verify the mass and {sup 235}U enrichment of declared UF{sub 6} containers used in the process of enrichment at GCEPs. In verifying declared LEU production, the inspectors also take samples for off-site destructive assay (DA) which provide accurate data, with 0.1% to 0.5% measurement uncertainty, on the enrichment of the UF{sub 6} feed, tails, and product. However, taking samples of UF{sub 6} for off-site analysis is a much more labor and resource intensive exercise for the operator and inspector. Furthermore, the operator must ship the samples off-site to the IAEA laboratory which delays the timeliness of results and interruptions to the continuity of knowledge (CofK) of the samples during their storage and transit. This paper contains an analysis of possible improvements in unattended and attended NDA systems such as process monitoring and possible on-site analysis of DA samples that could reduce the uncertainty of the inspector's measurements and provide more effective and efficient IAEA GCEPs safeguards. We also introduce examples advanced safeguards systems that could be assembled for unattended operation.

  11. NEAT : an efficient network enrichment analysis test

    NARCIS (Netherlands)

    Signorelli, Mirko; Vinciotti, Veronica; Wit, Ernst C

    2016-01-01

    BACKGROUND: Network enrichment analysis is a powerful method, which allows to integrate gene enrichment analysis with the information on relationships between genes that is provided by gene networks. Existing tests for network enrichment analysis deal only with undirected networks, they can be

  12. How people with multiple sclerosis rate their quality of life: an EQ-5D survey via the UK MS register.

    Directory of Open Access Journals (Sweden)

    Kerina H Jones

    Full Text Available INTRODUCTION: The EQ-5D is a widely-used, standardised, quality of life measure producing health profiles, indices and states. The aims of this study were to assess the role of various factors in how people with Multiple Sclerosis rate their quality of life, based on responses to the EQ-5D received via the web portal of the UK MS Register. METHODS: The 4516 responses to the EQ-5D (between May 2011 and April 2012 were collated with basic demographic and descriptive MS data and the resulting dataset was analysed in SPSS (v.20. RESULTS: The mean health state for people with MS was 59.73 (SD 22.4, median 61, compared to the UK population mean of 82.48 (which is approximately 1SD above the cohort mean. The characteristics of respondents with high health states (at or above +1SD were: better health profiles (most predictive dimension: Usual Activities, higher health indices, younger age, shorter durations of MS, female gender, relapsing-remitting MS, higher educational attainment and being in paid employment (all p-values<0.001. Conversely, the characteristics of respondents with low health states (at or below -1SD were: poorer health profiles (most predictive dimension: Mobility, lower health indices, older age, longer durations of MS, male gender, progressive MS, lower educational attainment and having an employment status of sick/disabled (p = 0.0014 for age, all other p-values<0.001. Particular living arrangements were not associated with either the high or low health status groups. CONCLUSIONS: This large-scale study has enabled in-depth analyses on how people with MS rate their quality of life, and it provides new knowledge on the various factors that contribute to their self-assessed health status. These findings demonstrate the impact of MS on quality of life, and they can be used to inform care provision and further research, to work towards enhancing the quality of life of people with MS.

  13. How People with Multiple Sclerosis Rate Their Quality of Life: An EQ-5D Survey via the UK MS Register

    Science.gov (United States)

    Jones, Kerina H.; Ford, David V.; Jones, Philip A.; John, Ann; Middleton, Rodden M.; Lockhart-Jones, Hazel; Peng, Jeffrey; Osborne, Lisa A.; Noble, J. Gareth

    2013-01-01

    Introduction The EQ-5D is a widely-used, standardised, quality of life measure producing health profiles, indices and states. The aims of this study were to assess the role of various factors in how people with Multiple Sclerosis rate their quality of life, based on responses to the EQ-5D received via the web portal of the UK MS Register. Methods The 4516 responses to the EQ-5D (between May 2011 and April 2012) were collated with basic demographic and descriptive MS data and the resulting dataset was analysed in SPSS (v.20). Results The mean health state for people with MS was 59.73 (SD 22.4, median 61), compared to the UK population mean of 82.48 (which is approximately 1SD above the cohort mean). The characteristics of respondents with high health states (at or above +1SD) were: better health profiles (most predictive dimension: Usual Activities), higher health indices, younger age, shorter durations of MS, female gender, relapsing-remitting MS, higher educational attainment and being in paid employment (all p-values<0.001). Conversely, the characteristics of respondents with low health states (at or below -1SD) were: poorer health profiles (most predictive dimension: Mobility), lower health indices, older age, longer durations of MS, male gender, progressive MS, lower educational attainment and having an employment status of sick/disabled (p = 0.0014 for age, all other p-values<0.001). Particular living arrangements were not associated with either the high or low health status groups. Conclusions This large-scale study has enabled in-depth analyses on how people with MS rate their quality of life, and it provides new knowledge on the various factors that contribute to their self-assessed health status. These findings demonstrate the impact of MS on quality of life, and they can be used to inform care provision and further research, to work towards enhancing the quality of life of people with MS. PMID:23776516

  14. Enriching Orphans’ Potentials through Interpersonal and Intrapersonal Intelligence Enrichment Activities

    Directory of Open Access Journals (Sweden)

    Nurulwahida Hj Azid

    2016-01-01

    Full Text Available Orphans are considered a minority and they should be given a greater emphasis so that they do not feel left out and can build their own lives without a sense of humility. This does not mean that the orphans should be pampered instead they should be given the confidence and motivation to strive for success in later life. Humility among orphans can be associated with interpersonal and intrapersonal intelligences. This study aims to evaluate the impact of problem-solving activity treatment based on the interpersonal and intrapersonal intelligences. 46 students from two orphanages were involved as the treatment group. The research design used was a one-group pretest-posttest design applied through a combination of quantitative and qualitative approaches. Enrichment activities that provided interpersonal and intrapersonal skills as evidenced in this study should be carried out regularly at orphanages. Our study has proven that orphans‟ rights to learn cannot be neglected and „no child left behind „policy needs to be carried through by everybody involved with orphans‟ well-being. Teachers and carers need to be trained to use these enrichment activities at their orphanages to help maximize the orphans‟ potentials.

  15. 5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila

    Science.gov (United States)

    Huang, Yu Shan; Ku, Hui Yu; Tsai, Yun Chi; Chang, Chin Hao; Pao, Sih Hua; Sun, Y. Henry; Chiou, Arthur

    2017-03-01

    5D images of engrailed (en) and eye gone (eyg) gene expressions during the course of the eye-antenna disc primordium (EADP) formation of Drosophila embryos from embryonic stages 13 through 16 were recorded via light sheet microscopy and analyzed to reveal the cell dynamics involved in the development of the EADP. Detailed analysis of the time-lapsed images revealed the process of EADP formation and its invagination trajectory, which involved an inversion of the EADP anterior-posterior axis relative to the body. Furthermore, analysis of the en-expression pattern in the EADP provided strong evidence that the EADP is derived from one of the en-expressing head segments.

  16. Adsorption of 3d, 4d, and 5d transition metal atoms on β 12—Borophene

    Science.gov (United States)

    Alvarez-Quiceno, J. C.; Schleder, G. R.; Marinho, E., Jr.; Fazzio, A.

    2017-08-01

    We perform an ab initio study of the electronic structure and magnetic properties of 3d, 4d and 5d transition metals (TM) adsorbed on freestanding and Ag(1 1 1)-supported {β12} -borophene. The stability of TM adsorption is high for all atoms and increases with the period. For the 3d TM adsorption we observed strong exchange effects. The Ag(1 1 1)-surface induced small effects on the calculated properties. Studying the magnetic interaction between TMs, VIB atoms showed direct exchange, while VIIB and Fe showed 2p(B)-mediated indirect exchange. In the ultimate case of a one-dimensional TM array, Ru and Os also show direct exchange effects.

  17. 76 FR 11523 - Atomic Safety and Licensing Board; AREVA Enrichment Services, LLC (Eagle Rock Enrichment Facility...

    Science.gov (United States)

    2011-03-02

    ... COMMISSION Atomic Safety and Licensing Board; AREVA Enrichment Services, LLC (Eagle Rock Enrichment Facility.... Craig M. White. In this 10 CFR part 70 proceeding regarding the request of applicant AREVA Enrichment... Safeguards Information for Contention Preparation; In the Matter of AREVA Enrichment Services, LLC (Eagle...

  18. A New Fate of a Warped 5D FLRW Model with a U(1) Scalar Gauge Field

    Science.gov (United States)

    Slagter, Reinoud Jan; Pan, Supriya

    2016-09-01

    If we live on the weak brane with zero effective cosmological constant in a warped 5D bulk spacetime, gravitational waves and brane fluctuations can be generated by a part of the 5D Weyl tensor and carries information of the gravitational field outside the brane. We consider on a cylindrical symmetric warped FLRW background a U(1) self-gravitating scalar field coupled to a gauge field without bulk matter. It turns out that brane fluctuations can be formed dynamically, due to the modified energy-momentum tensor components of the scalar-gauge field ("cosmic string"). As a result, we find that the late-time behavior could significantly deviate from the standard evolution of the universe. The effect is triggered by the time-dependent warpfactor with two branches of the form ± 1/√{τ r}√{(c_1e^{√{2τ } t}+c_2e^{-√{2τ } t})(c_3e^{√{2τ } r}+c_4e^{-√{2τ } r})} ( with τ , c_i constants) and the modified brane equations comparable with a dark energy effect. This is a brane-world mechanism, not present in standard 4D FLRW, where the large disturbances are rapidly damped as the expansion proceed. Because gravity can propagate in the bulk, the cosmic string can build up a huge angle deficit (or mass per unit length) by the warpfactor and can induce massive KK-modes felt on the brane. Disturbances in the spatial components of the stress-energy tensor cause cylindrical symmetric waves, amplified due to the presence of the bulk space and warpfactor. They could survive the natural damping due to the expansion of the universe. It turns out that one of the metric components becomes singular at the moment the warp factor develops an extremum. This behavior could have influence on the possibility of a transition from acceleration to deceleration or vice versa.

  19. Validity, responsiveness, and minimal clinically important difference of EQ-5D-5L in stroke patients undergoing rehabilitation.

    Science.gov (United States)

    Chen, Poyu; Lin, Keh-Chung; Liing, Rong-Jiuan; Wu, Ching-Yi; Chen, Chia-Ling; Chang, Ku-Chou

    2016-06-01

    To examine the criterion validity, responsiveness, and minimal clinically important difference (MCID) of the EuroQoL 5-Dimensions Questionnaire (EQ-5D-5L) and visual analog scale (EQ-VAS) in people receiving rehabilitation after stroke. The EQ-5D-5L, along with four criterion measures-the Medical Research Council scales for muscle strength, the Fugl-Meyer assessment, the functional independence measure, and the Stroke Impact Scale-was administered to 65 patients with stroke before and after 3- to 4-week therapy. Criterion validity was estimated using the Spearman correlation coefficient. Responsiveness was analyzed by the effect size, standardized response mean (SRM), and criterion responsiveness. The MCID was determined by anchor-based and distribution-based approaches. The percentage of patients exceeding the MCID was also reported. Concurrent validity of the EQ-Index was better compared with the EQ-VAS. The EQ-Index has better power for predicting the rehabilitation outcome in the activities of daily living than other motor-related outcome measures. The EQ-Index was moderately responsive to change (SRM = 0.63), whereas the EQ-VAS was only mildly responsive to change. The MCID estimation of the EQ-Index (the percentage of patients exceeding the MCID) was 0.10 (33.8 %) and 0.10 (33.8 %) based on the anchor-based and distribution-based approaches, respectively, and the estimation of EQ-VAS was 8.61 (41.5 %) and 10.82 (32.3 %). The EQ-Index has shown reasonable concurrent validity, limited predictive validity, and acceptable responsiveness for detecting the health-related quality of life in stroke patients undergoing rehabilitation, but not for EQ-VAS. Future research considering different recovery stages after stroke is warranted to validate these estimations.

  20. Selenium enrichment of table eggs.

    Science.gov (United States)

    Bennett, D C; Cheng, K M

    2010-10-01

    Selenium is an essential trace element with a recommended dietary allowance for human adults of 55 μg/d. However, there is evidence that greater dietary intakes may have possible health benefits, including a reduction in the risk of cancer. Several studies have shown the feasibility of enriching eggs using organic Se and that Se-enriched eggs are an effective way to supplement human diets. However, few studies have examined the response of egg Se concentration to high (>1 μg/g) dietary organic Se intake by the laying hens. The objective of the current study is to examine the effect of higher dietary organic Se levels on production, egg mass, and egg Se levels. These were assessed by feeding 3 breeds of laying hens (Barred Plymouth Rock, Lohmann Brown, Lohmann White) a basal diet containing 0.3 μg of Se/g of diet as Na2SeO3. Into this diet, Se yeast (SelenoSource AF 600), an organic source of Se, was added at 1.0, 2.4, or 5.1 μg of Se/g of diet for 4 wk. Feed consumption, egg production, and egg mass were not affected by the dietary Se concentration in all 3 breeds. Within the range of Se levels employed in the laying hens' diet, egg Se content increased linearly as dietary levels of Se increased. The results of this study indicate that feeding up to 5.1 µg/g of Se will not affect egg production and the welfare of the laying hen and is a practical way of producing Se-enriched eggs for the consumers.

  1. Quality of Life Assessment Using EuroQOL EQ-5D Questionnaire in Patients with Deep Infiltrating Endometriosis: The Relation with Symptoms and Locations

    Science.gov (United States)

    Touboul, C.; Amate, P.; Ballester, M.; Bazot, M.; Fauconnier, A.; Daraï, E.

    2013-01-01

    The objective of this study was to evaluate the quality of life (QOL) of patients with deep infiltrating endometriosis (DIE) using EuroQOL (EQ-5D) and its correlation with symptoms and locations of endometriotic lesions. One hundred and fifty-nine patients referred for DIE from January 2011 to April 2011 were prospectively invited to complete questionnaires evaluating symptoms associated with endometriosis as well as the EQ-5D questionnaire and health state. Patients also had locations of DIE evaluated by clinical examination and magnetic resonance imaging (MRI). All 159 patients completed the questionnaires. Item response rate was 91.1%. The most intense symptoms were dysmenorrhea (7.1/10), painful defecation (6.3/10), and fatigue (6.0/10). Mean (SD) scores were 77 (14) for the EQ-5D questionnaire and 63.4 (21) for the health state. A relation was observed between the EQ-5D questionnaire and the presence of dysmenorrhea, dyspareunia, cyclic pelvic pain, painful defecation, and diarrhea or constipation. Vaginal and rectal infiltrations were significantly associated with altered EQ-5D and health state scores. The EQ-5D questionnaire is easy to complete and well related to symptoms of DIE. Rectal and vaginal infiltrations were found to be determinant factors of altered QOL by the EQ-5D questionnaire and health state. PMID:26464845

  2. Boron enrichment in martian clay.

    Directory of Open Access Journals (Sweden)

    James D Stephenson

    Full Text Available We have detected a concentration of boron in martian clay far in excess of that in any previously reported extra-terrestrial object. This enrichment indicates that the chemistry necessary for the formation of ribose, a key component of RNA, could have existed on Mars since the formation of early clay deposits, contemporary to the emergence of life on Earth. Given the greater similarity of Earth and Mars early in their geological history, and the extensive disruption of Earth's earliest mineralogy by plate tectonics, we suggest that the conditions for prebiotic ribose synthesis may be better understood by further Mars exploration.

  3. Boron Enrichment in Martian Clay

    Science.gov (United States)

    Nagashima, Kazuhide; Freeland, Stephen J.

    2013-01-01

    We have detected a concentration of boron in martian clay far in excess of that in any previously reported extra-terrestrial object. This enrichment indicates that the chemistry necessary for the formation of ribose, a key component of RNA, could have existed on Mars since the formation of early clay deposits, contemporary to the emergence of life on Earth. Given the greater similarity of Earth and Mars early in their geological history, and the extensive disruption of Earth's earliest mineralogy by plate tectonics, we suggest that the conditions for prebiotic ribose synthesis may be better understood by further Mars exploration. PMID:23762242

  4. Environmental Enrichment in Kennelled Pit Bull Terriers (Canis lupus familiaris).

    Science.gov (United States)

    Kiddie, Jenna; Bodymore, Anna; Dittrich, Alex

    2017-03-23

    Although social enrichment can be considered beneficial in helping dogs cope with the kennel environment, when taking individual needs into account, it places a large demand on the carers and may not be appropriate in under-resourced kennels. Some kennels are also designed in such a way that there is too much social interaction, in that individuals cannot choose to distance themselves from conspecifics. This study therefore aimed to assess the effects of easily accessible enrichment on the behaviour of kennelled Pit Bull Terrier type dogs rescued from a dog-fighting ring in the Philippines. Thirty-six dogs were allocated to one of three treatment groups following a matched-subject design: (i) cardboard bed provision; (ii) coconut provision; and (iii) visual contact with dogs housed in adjacent cages obstructed with cardboard partitions. Behavioural diversity and the duration and frequency of individual behaviours were analysed using linear mixed-effect models. Yawning frequencies and time spent lying down and sitting decreased during treatment. No particular treatment was more influential in these behavioural changes. In conclusion, enrichment, regardless of type, affected the dogs' behaviour, with some effects depending on the sex of the dogs. Therefore, it is possible to cheaply and sustainably enrich the lives of dogs living in highly constrained environments, however, further research is required to refine the methods used.

  5. Estimating the burden of disease in chronic pain with and without neuropathic characteristics: does the choice between the EQ-5D and SF-6D matter?

    Science.gov (United States)

    Torrance, Nicola; Lawson, Kenny D; Afolabi, Ebenezer; Bennett, Michael I; Serpell, Michael G; Dunn, Kate M; Smith, Blair H

    2014-10-01

    The EQ-5D and Short Form (SF)12 are widely used generic health-related quality of life (HRQoL) questionnaires. They can be used to derive health utility index scores, on a scale where 0 is equivalent to death and 1 represents full health, with scores less than zero representing states "worse than death." We compared EQ-5D or SF-6D health utility index scores in patients with no chronic pain, and chronic pain with and without neuropathic characteristics (NC), and to explore their discriminant ability for pain severity. Self-reported health and chronic pain status was collected as part of a UK general population survey (n=4451). We found moderate agreement between individual dimensions of EQ-5D and SF-6D, with most highly correlated dimensions found for mental health and anxiety/depression, role limitations and usual activities, and pain and pain/discomfort. Overall 43% reported full health on the EQ-5D, compared with only 4.2% on the SF-6D. There were significant differences in mean utilities for chronic pain with NC (EQ-5D 0.47 vs SF-6D 0.62) and especially for severe pain (EQ-5D 0.33 vs SF-6D 0.58). On the EQ-5D, 17% of those with chronic pain with NC and 3% without NC scored "worse than death," a state which is not possible using the SF-6D. Health utilities derived from EQ-5D and SF-12/36 can discriminate between group differences for chronic pain with and without NC and greater pain severity. However, the instruments generate widely differing HRQoL scores for the same patient groups. The choice between using the EQ-5D or SF-6D matters greatly when estimating the burden of disease. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  6. An exploration of differences between Japan and two European countries in the self-reporting and valuation of pain and discomfort on the EQ-5D.

    Science.gov (United States)

    Feng, Yan; Herdman, Mike; van Nooten, Floortje; Cleeland, Charles; Parkin, David; Ikeda, Shunya; Igarashi, Ataru; Devlin, Nancy J

    2017-08-01

    To investigate the systematic differences in the self-reporting and valuation of overall health and, in particular, pain/discomfort between three countries (England/UK, Japan, and Spain) on the EQ-5D. Existing datasets were used to explore differences in responses on the EQ-5D descriptive system between Japan (3L and 5L), the UK (3L), England (5L), and Spain (5L), particularly on the dimension of pain/discomfort. The role of different EQ dimensions in determining self-reported overall health scores for the EuroQol visual analog scale (EQ-VAS) was investigated using ordinary least squares regression. Time trade-off (TTO) results from Japanese and UK respondents for the EQ-5D-3L as well as Japanese and English respondents for the EQ-5D-5L were compared using t tests. For the EQ-5D-3L, a higher percentage of respondents in Japan than in the UK reported 'no pain/discomfort' (81.6 vs 67.0%, respectively); for the EQ-5D-5L, the proportions were 79.2% in Spain, 73.2% in Japan, and 63-64% in England, after adjusting for age differences in samples. The 'pain/discomfort' dimension had the largest impact on respondents' self-reported EQ-VAS only for EQ-5D-3L in Japan. Using the EQ-5D-3L, Japanese respondents were considerably less willing to trade off time to avoid pain/discomfort than the UK respondents; for example, moving from health state, 11121 (some problems with pain/discomfort) to 11131 (extreme pain/discomfort) represented a decrement of 0.65 on the observed TTO value in the UK compared with 0.15 in Japan. Using the EQ-5D-5L, Japanese respondents were also less willing to trade off time to avoid pain/discomfort than respondents in England; however, the difference in values was much smaller than that observed using EQ-5D-3L data. This study provides evidence of between-country differences in the self-reporting and valuation of health, including pain/discomfort, when using EQ-5D in general population samples. The results suggest a need for caution when comparing or

  7. Resourcing in Co-Design

    DEFF Research Database (Denmark)

    Ylirisku, Salu; Buur, Jacob; Revsbæk, Line

    2016-01-01

    in collaborative design processes. We define the concept of resourcing on the basis of pragmatist process theories and complexity theory perspectives of social life, which enable us to explicate the gap between managerial thinking that understands resources as objective entities to be planned and controlled......This paper introduces the concept of ‘resourcing’ to describe the fundamental activity of negotiating the use of what is available for co-design. Even though resourcing is an ever-present undertaking in all co-designing, no theoretical concept has thus far addressed the constitutive practices......, and the actual unfolding of co-design in complex responsive conversation. Through the analysis of three co-design events we illustrate how the different response sensitivities of co-designers can diversify and enrich resourcing. The analyses also reveal that resourcing is a dynamically evolving process...

  8. Modeling Ranking, Time Trade-Off and Visual Analogue Scale Values for EQ-5D Health States

    Science.gov (United States)

    Craig, Benjamin M.; Busschbach, Jan J. V.; Salomon, Joshua A.

    2009-01-01

    Background There is rising interest in eliciting health state valuations using rankings. Due to their relative simplicity, ordinal measurement methods may offer an attractive practical alternative to cardinal methods, such as time trade-off (TTO) and visual analog scale (VAS). In this paper, we explore alternative models for estimating cardinal health state values from rank responses in a unique multi-country database. We highlight an estimation challenge pertaining to health states just below perfect health (the ‘non-optimal gap’) and propose an analytic solution to ameliorate this problem. Methods Using rank, a standardized protocol developed by the EuroQol Group, TTO and VAS responses were collected for 43 health states in eight countries: Slovenia, Argentina, Denmark, Japan, Netherlands, Spain, United Kingdom, and United States, yielding a sample of 179,431 state responses from 11,483 subjects. States were described using the EQ-5D system, which allows for three different possible levels on five different dimensions of health. We estimated conditional logit and probit regression models for rank responses. The regressions included 17 health-state attribute variables reflecting specific levels on each dimension and counts of different levels across dimensions. This flexible specification accommodates previously published valuation models, such as models applied in the United Kingdom and United States. In addition to fitting standard conditional logit and probit models, which assume equal variance across health states (homoskedasticity), we examined a heteroskedastic probit model that assumes no variance for the two points anchoring the scale (“optimal health” and “dead”) and relaxes the equal-variance assumption for all other states. Rank-based predictions for the 243 unique states defined by the EQ-5D system were compared to predictions from conventional linear models fitted to TTO and VAS responses. Results By construction, the TTO and VAS models

  9. A cross sectional survey on health-related quality of life of elementary school students using the Korean version of the EQ-5D-Y.

    Science.gov (United States)

    Kim, Sang-Kyu; Jo, Min-Woo; Kim, Seon-Ha

    2017-01-01

    The Korean version of the EQ-5D-Y was launched in 2015 by the EuroQol group. Currently, there is no HRQOL data obtained by using the EQ-5D-Y in Korea. This study aimed to measure health-related quality of life of Korean elementary school students using the EQ-5D-Y. Elementary school students were recruited from 11 primary schools in Gyungbuk, South Korea. The EQ-5D-Y was self-administered in the sample population. Demographic characteristics were collected from the subjects' parents or guardians. The percentage of respondents reporting problems and VAS scores were calculated. Feasibility of the EQ-5D-Y was assessed by analysing the proportion of missing responses. The percentage of reported problems on the dimensions and VAS score between groups were compared by demographic factors. A total of 2,494 questionnaires were collected. There were 24 (0.96%) missing responses on the EQ-5D-Y and 187 (7.5%) missing VAS score responses. The proportion of reported problems ranged from 2.3% on the mobility dimension to 9.8% on the "having pain or discomfort" dimension. There was no significant difference in the proportion of problems by age group in male participants. However, in females, the older group reported significantly more problems on the "having pain or discomfort" and "feeling worried, sad, or unhappy" dimensions compared to the younger group. Students living with parents with the lowest educational level reported significantly more problems on the "looking after myself" and "doing usual activities" dimensions than did those living with parents with higher levels of education. This study showed the distribution of health-related quality of life and explored the feasibility of the EQ-5D-Y for measuring health-related quality of life in Korean elementary school students. Further studies are required to examine other psychometric properties of the Korean EQ-5D-Y.

  10. Scalar fluctuations of the scalar metric during inflation from a non-perturbative 5D large-scale repulsive gravity model

    OpenAIRE

    Madriz Aguilar. Jose Edgar; Reyes, Luz Marina; Moreno, Claudia; Bellini, Mauricio

    2013-01-01

    We develop a non-perturbative formalism for scalar metric fluctuations from a 5D extended version of General Relativity in vacuum. In this work we concentrate our efforts on calculations valid on large cosmological scales, which are the dominant during the inflationary phase of the universe. The resulting metric on this limit case is obtained after implementing a planar coordinate transformation on a 5D Ricci-flat metric solution. We calculate the spectrum of these fluctuations on an ...

  11. Generating Orthorectified Multi-Perspective 2.5D Maps to Facilitate Web GIS-Based Visualization and Exploitation of Massive 3D City Models

    Directory of Open Access Journals (Sweden)

    Jianming Liang

    2016-11-01

    Full Text Available 2.5D map is a convenient and efficient approach to exploiting a massive three-dimensional (3D city model in web GIS. With the rapid development of oblique airborne photogrammetry and photo-based 3D reconstruction, 3D city models are becoming more and more accessible. 3D Geographic Information System (GIS can support the interactive visualization of massive 3D city models on various platforms and devices. However, the value and accessibility of existing 3D city models can be augmented by integrating them into web-based two-dimensional (2D GIS applications. In this paper, we present a step-by-step workflow for generating orthorectified oblique images (2.5D maps from massive 3D city models. The proposed framework can produce 2.5D maps from an arbitrary perspective, defined by the elevation angle and azimuth angle of a virtual orthographic camera. We demonstrate how 2.5D maps can benefit web-based visualization and exploitation of massive 3D city models. We conclude that a 2.5D map is a compact data representation optimized for web data streaming of 3D city models and that geometric analysis of buildings can be effectively conducted on 2.5D maps.

  12. Λ(t) CDM and the present accelerating expansion of the universe from 5D scalar vacuum

    Science.gov (United States)

    Madriz Aguilar, José Edgar; Zamarripa, J.; Peraza, A.; Licea, J. A.

    2017-12-01

    In this letter we investigate some consequences of considering our 4D observable universe as locally and isometrically embedded in a 5D spacetime, where gravity is described by a Brans-Dicke theory in vacuum. Once we impose the embedding conditions we obtain that gravity on the 4D spacetime is governed by the Einstein field equations modified by an extra term that can play the role of a dynamical cosmological constant. Two examples were studied. In the first we derive a cosmological model of a universe filled only with a cosmological constant. In the second we obtain a cosmological solution describing a universe filled with matter, radiation and a dynamical cosmological constant. We constrain the model by using the current observational data combination Planck + WP + BAO + SN. The present acceleration in the expansion of the universe is explained by the geometrically induced dynamical cosmological constant avoiding the introduction of a dark energy component and without addressing the underlying cosmological constant problem. Moreover, all 4D matter sources are geometrically induced in the same manner as it is usually done in the Wesson's induced matter theory.

  13. Endocytosis of ABCG2 drug transporter caused by binding of 5D3 antibody: trafficking mechanisms and intracellular fate.

    Science.gov (United States)

    Studzian, Maciej; Bartosz, Grzegorz; Pulaski, Lukasz

    2015-08-01

    ABCG2, a metabolite and xenobiotic transporter located at the plasma membrane (predominantly in barrier tissues and progenitor cells), undergoes a direct progressive endocytosis process from plasma membrane to intracellular compartments upon binding of 5D3 monoclonal antibody. This antibody is specific to an external epitope on the protein molecule and locks it in a discrete conformation within its activity cycle, presumably providing a structural trigger for the observed internalization phenomenon. Using routine and novel assays, we show that ABCG2 is endocytosed by a mixed mechanism: partially via a rapid, clathrin-dependent pathway and partially in a cholesterol-dependent, caveolin-independent manner. While the internalization process is entirely dynamin-dependent and converges initially at the early endosome, subsequent intracellular fate of ABCG2 is again twofold: endocytosis leads to only partial lysosomal degradation, while a significant fraction of the protein is retained in a post-endosomal compartment with the possibility of at least partial recycling back to the cell surface. This externally triggered, conformation-related trafficking pathway may serve as a general regulatory paradigm for membrane transporters, and its discovery was made possible thanks to consistent application of quantitative methods. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. ( p, q)-webs of DIM representations, 5d N=1 instanton partition functions and qq-characters

    Science.gov (United States)

    Bourgine, J.-E.; Fukuda, M.; Harada, K.; Matsuo, Y.; Zhu, R.-D.

    2017-11-01

    Instanton partition functions of N=1 5d Super Yang-Mills reduced on S 1 can be engineered in type IIB string theory from the ( p, q)-branes web diagram. To this diagram is superimposed a web of representations of the Ding-Iohara-Miki (DIM) algebra that acts on the partition function. In this correspondence, each segment is associated to a representation, and the (topological string) vertex is identified with the intertwiner operator constructed by Awata, Feigin and Shiraishi. We define a new intertwiner acting on the representation spaces of levels (1, n) ⊗ (0, m) → (1, n + m), thereby generalizing to higher rank m the original construction. It allows us to use a folded version of the usual ( p, q)-web diagram, bringing great simplifications to actual computations. As a result, the characterization of Gaiotto states and vertical intertwiners, previously obtained by some of the authors, is uplifted to operator relations acting in the Fock space of horizontal representations. We further develop a method to build qq-characters of linear quivers based on the horizontal action of DIM elements. While fundamental qq-characters can be built using the coproduct, higher ones require the introduction of a (quantum) Weyl reflection acting on tensor products of DIM generators.

  15. Ab initio calculations for structural, electronic and magnetic behaviors of nitrogenized monolayer graphene decorated with 5d transition metal atoms

    Science.gov (United States)

    Rafique, Muhammad; Shuai, Yong; Xu, Meng; Zhang, Guohua; Guo, Yanming

    2017-09-01

    Graphene-based magnetic materials have revealed great potential for developing high-performance electronic units at sub-nanometer such as spintronic data storage devices. However, a significant ferromagnetism behavior and ample band gap in the electronic structure of graphene is required before it can be used for actual engineering applications. Based on first-principles calculations, here we demonstrate the structural, electronic and magnetic behaviors of 5d transition metal (TM) atom-substituted nitrogenized monolayer graphene. We find that, during TMN(3)4 cluster-substitution, tight bonding occurs between impurity atoms and graphene with significant binding energies. Charge transfer occurs from graphene layer to the TMN(3)4 clusters. Interestingly, PtN3, TaN4 and ReN4 cluster-doped graphene structures exhibit dilute magnetic semiconductor behavior with 1.00 μB, 1.04 μB and 1.05 μB magnetic moments, respectively. While, OsN4 and PtN4 cluster-doped structures display nonmagnetic direct band gap semiconductor behavior. Remaining, TMN(3)4 cluster-doped graphene complexes exhibit half metal properties. Detailed analysis of density of states (DOS) plots indicate that d orbitals of TM atoms should be responsible for arising magnetic moments in graphene. Given results pave a new route for potential applications of dilute magnetic semiconductors and half-metals in spintronic devices by employing TMN(3)4 cluster-doped graphene complexes.

  16. Accurate electronic free energies of the 3 d ,4 d , and 5 d transition metals at high temperatures

    Science.gov (United States)

    Zhang, Xi; Grabowski, Blazej; Körmann, Fritz; Freysoldt, Christoph; Neugebauer, Jörg

    2017-04-01

    Free energies of bulk materials are nowadays routinely computed by density functional theory. In particular for metals, electronic excitations can significantly contribute to the free energy. For an ideal static lattice, this contribution can be obtained at low computational cost, e.g., from the electronic density of states derived at T =0 K or by utilizing the Sommerfeld approximation. The error introduced by these approximations at elevated temperatures is rarely known. The error arising from the ideal lattice approximation is likewise unexplored but computationally much more challenging to overcome. In order to shed light on these issues we have computed the electronic free energies for all 3 d ,4 d , and 5 d transition elements on the ideal lattices of the bcc, fcc, and hcp structures using finite-temperature density-functional theory. For a subset of elements we have explored the impact of explicit thermal vibrations on the electronic free energies by using ab initio molecular dynamics simulations. We provide an analysis of the observed chemical trends in terms of the electronic density of states and the canonical d band model and quantify the errors in the approximate methods. The electronic contribution to the heat capacities and the corresponding errors due to the different approximations are studied as well.

  17. Health related quality of life six months following surgical treatment for secondary peritonitis – using the EQ-5D questionnaire

    Directory of Open Access Journals (Sweden)

    Steller E Philip

    2007-07-01

    Full Text Available Abstract Background To compare health related quality of life (HR-QoL in patients surgically treated for secondary peritonitis to that of a healthy population. And to prospectively identify factors associated with poorer (lower HR-QoL. Design A prospective cohort of secondary peritonitis patients was mailed the EQ-5D and EQ-VAS 6-months following initial laparotomy. Setting Multicenter study in two academic and seven regional teaching hospitals. Patients 130 of the 155 eligible patients (84% responded to the HR-QoL questionnaires. Results HR-QoL was significantly worse on all dimensions in peritonitis patients than in a healthy reference population. Peritonitis characteristics at initial presentation were not associated with HR-QoL at six months. A more complicated course of the disease leading to longer hospitalization times and patients with an enterostomy had a negative impact on the mobility (p = 0.02, self-care (p Conclusion Six months following initial surgery, patients with secondary peritonitis report more problems in HR-QoL than a healthy reference population. Unfavorable disease characteristics at initial presentation were not predictive for poorer HR-QoL, but a more complicated course of the disease was most predictive of HR-QoL at 6 months.

  18. A Reconfigurable System Approach to the Direct Kinematics of a 5 D.o.f Robotic Manipulator

    Directory of Open Access Journals (Sweden)

    Diego F. Sánchez

    2010-01-01

    Full Text Available Hardware acceleration in high performance computer systems has a particular interest for many engineering and scientific applications in which a large number of arithmetic operations and transcendental functions must be computed. In this paper a hardware architecture for computing direct kinematics of robot manipulators with 5 degrees of freedom (5 D.o.f using floating-point arithmetic is presented for 32, 43, and 64 bit-width representations and it is implemented in Field Programmable Gate Arrays (FPGAs. The proposed architecture has been developed using several floating-point libraries for arithmetic and transcendental functions operators, allowing the designer to select (pre-synthesis a suitable bit-width representation according to the accuracy and dynamic range, as well as the area, elapsed time and power consumption requirements of the application. Synthesis results demonstrate the effectiveness and high performance of the implemented cores on commercial FPGAs. Simulation results have been addressed in order to compute the Mean Square Error (MSE, using the Matlab as statistical estimator, validating the correct behavior of the implemented cores. Additionally, the processing time of the hardware architecture was compared with the same formulation implemented in software, using the PowerPC (FPGA embedded processor, demonstrating that the hardware architecture speeds-up by factor of 1298 the software implementation.

  19. Study of electron-vibrational interaction in 5d states of Ce{sup 3+} ions in the chloroapatite system

    Energy Technology Data Exchange (ETDEWEB)

    Bhoyar, Priyanka D. [Department of Physics, R.T.M. Nagpur University, Nagpur, 440033 (India); Brik, M.G., E-mail: brik@ut.ee [College of Sciences, Chongqing University of Posts and Telecommunications, Chongqing, 400065 (China); Institute of Physics, University of Tartu, Ravila 14C, Tartu, 50411 (Estonia); Institute of Physics, Polish Academy of Sciences, al. Lotnikow 32/46, 02-668, Warsaw (Poland); Institute of Physics, Jan Dlugosz University, Armii Krajowej 13/15, PL-42200, Czestochowa (Poland); Dhoble, S.J., E-mail: sjdhoble@rediffmail.com [Department of Physics, R.T.M. Nagpur University, Nagpur, 440033 (India)

    2016-08-15

    Electron-vibrational interaction (EVI) in interconfigurational 5d-4f transition of Ce{sup 3+}-doped alkaline-earth chlorophosphates, also known as apatites, is studied for the first time in this work. Using the configurational coordinate model, the main EVI parameters such as Huang-Rhys factor, effective phonon energy and the zero-phonon line (ZPL) position are determined for all samples studied. Photoluminescence characteristics of these compounds are utilized to estimate EVI parameters. As a reliable test validating the obtained results, the emission band shape of was modeled to yield good agreement with experimental emission spectra. The values of EVI parameters were systematically compared for all studied materials as well as with similar systems with halide ions. - Highlights: • EVI in Ce{sup 3+}-doped alkaline-earth halochlorophosphates is studied for the first time in this work. • The EVI parameters are estimated using the configurational coordinate model. • Estimated EVI parameters are validated by modeling emission spectra. • Parameters are systematically compared.

  20. improvisation and utilization of resources in the teaching and ...

    African Journals Online (AJOL)

    game used as resource enable less able children to stay on task and remain motivated for a longer period. There are varieties of resources, which the biology teacher can readily use to enrich learning. These resources are models, ... space has been a great concern to science educators. The implementation of biology ...

  1. Environmental enrichment in farm, zoo, companion and experimental animals

    Directory of Open Access Journals (Sweden)

    Vučinić Marijana

    2009-01-01

    Full Text Available The paper deals with environmental enrichment for domestic animals at farms, animals in zoos, experimental animals and pet animals. Also, the paper defines and describes different strategies of environmental enrichment. Environmental enrichment is a simple and effective mean of prevention of boredom, behavioral disorders as well as an effective mean of improving animal welfare in farm, zoo, companion and experimental animals. Different items and materials may be used for environmental enrichment. They need to be evaluated for use by taking into account the following: the species of an animal, its needs, habits and capabilities, the type of an enrichment device, the device's ability to stimulate the animal's interest and the safety of the device. Enrichment programmes should always include two forms of enrichment: behavioral enrichment and environmental enrichment. Enrichment comes in many forms such as structural or physical enrichment, sensory enrichment (auditory and olfactory stimulation, dietary enrichment, manipulatable enrichment and social enrichment.

  2. Psychometric validation of the EuroQoL 5-Dimension 5-Level (EQ-5D-5L) in Chinese patients with adolescent idiopathic scoliosis.

    Science.gov (United States)

    Cheung, Prudence Wing Hang; Wong, Carlos King Ho; Samartzis, Dino; Luk, Keith Dip Kei; Lam, Cindy Lo Kuen; Cheung, Kenneth Man Chee; Cheung, Jason Pui Yin

    2016-01-01

    Scoliosis is a common spinal deformity that occurs often during adolescence. Previous studies suggested that adolescent idiopathic scoliosis (AIS) patients can have various aspects of their lives being affected, due to disease presentation and/or treatment received. It is important to define a reliable instrument based on which the affected patients' health-related quality of life can be assessed. This study aims to assess the validity, reliability and sensitivity of the EuroQoL 5-dimension 5-level (EQ-5D-5L) in Chinese patients with AIS. Adolescent idiopathic scoliosis patients of Chinese descent were prospectively recruited to complete both the traditional Chinese versions of the EQ-5D-5L and the refined Scoliosis Research Society-22 (SRS-22r) questionnaires. Patients' demographic profiles and corresponding clinical parameters including treatment modalities, spinal curve pattern and magnitude, and duration of bracing were recorded. Telephone interviews were then conducted at least two weeks later for the assessment of test-retest reliability. Statistical analysis was performed: construct validity of the EQ-5D-5L domains were assessed using Spearman's correlation test against the SRS-22r; whereas intra-class correlation coefficient (ICC) was used to assess the test-retest reliability, and agreement over the test-retest period was expressed in percentages. Also, the sensitivity of the EQ-5D-5L in differentiating various clinical known groups was determined by effect size, independent t-test and analysis of variance. A total of 227 AIS patients were recruited. Scores of domains of the EQ-5D-5L correlated significantly (r: 0.57-0.74) with the scores of the SRS-22r domains that were intended to measure similar constructs, supporting construct validity. The EQ-5D-5L domain responses and utility scores showed good test-retest reliability (ICC: 0.777; agreement: 76.4 -98.1 %). Internal consistency was good (Cronbach's α: 0.78) for the EQ-5D-5L utility score. The EQ-5

  3. A resource perspective on the work-home interface: the work-home resources model.

    Science.gov (United States)

    ten Brummelhuis, Lieke L; Bakker, Arnold B

    2012-10-01

    The objective of this article is to provide a theoretical framework explaining positive and negative work-home processes integrally. Using insights from conservation of resources theory, we explain how personal resources (e.g., time, energy, and mood) link demanding and resourceful aspects of one domain to outcomes in the other domain. The resulting work-home resources (W-HR) model describes work-home conflict as a process whereby demands in one domain deplete personal resources and impede accomplishments in the other domain. Enrichment is described as a process of resource accumulation: Work and home resources increase personal resources. Those personal resources, in turn, can be utilized to improve home and work outcomes. Moreover, our resource approach to the work-home interface allows us to address two other issues that have thus far lacked a solid theoretical foundation. The W-HR model also explains how conditional factors such as personality and culture may influence the occurrence of work-home conflict and enrichment. Furthermore, the model allows us to examine how work-home conflict and enrichment develop over time. Finally, the model provides useful insights for other psychology subdisciplines, such as gender studies and developmental psychology.

  4. A simple visual analog scale for pain is as responsive as the WOMAC, the SF-36, and the EQ-5D in measuring outcomes of revision hip arthroplasty.

    Science.gov (United States)

    Zampelis, Vasilis; Ornstein, Ewald; Franzén, Herbert; Atroshi, Isam

    2014-04-01

    Little is known about the comparative performance of patient-reported outcome measures in revision hip arthroplasty. We compared the performance of the WOMAC, the SF-36, the EQ-5D, and a pain-related visual analog scale (VAS) in revision hip arthroplasty. 45 patients with aseptic prosthetic loosening following primary hip arthroplasty completed the WOMAC, the SF-36, the EQ-5D, and a VAS for pain-at baseline and 2 years after revision. Responsiveness of the measures was compared with the effect size (with ≥ 0.8 being considered large). Agreement between scales measuring the same type of outcome (pain or physical function) was assessed with the Bland-Altman method. The mean preoperative scores for the pain and physical function scales of WOMAC and SF-36, EQ-5D index, and VAS for pain improved statistically significantly 2 years after revision. The effect size for the WOMAC pain was 1.7, that for SF-36 pain was 1.4, that for WOMAC physical function was 1.6, that for SF-36 physical function was 0.8, and that for EQ-5D index was 1.2. The VAS for pain had an effect size of 2.1, which was larger than that for SF-36 pain and for the EQ-5D index (p ≤ 0.03) but not for WOMAC pain (p = 0.2). The limits of agreement between WOMAC pain, SF-36 pain, and the VAS scale measuring pain-and between the WOMAC and SF-36 scales measuring physical function-were wide. Internal-consistency reliability was high for the WOMAC and SF-36 scales but low for the EQ-5D. In patients with first-time revision hip arthroplasty done for aseptic loosening, the WOMAC, SF-36, and EQ-5D showed high responsiveness in measuring patient-reported outcomes and the simple VAS for pain performed equally well.

  5. Semantically Enriched Data Access Policies in eHealth.

    Science.gov (United States)

    Drozdowicz, Michał; Ganzha, Maria; Paprzycki, Marcin

    2016-11-01

    Internet of Things (IoT) requires novel solutions to facilitate autonomous, though controlled, resource access. Access policies have to facilitate interactions between heterogeneous entities (devices and humans). Here, we focus our attention on access control in eHealth. We propose an approach based on enriching policies, based on well-known and widely-used eXtensible Access Control Markup Language, with semantics. In the paper we describe an implementation of a Policy Information Point integrated with the HL7 Security and Privacy Ontology.

  6. Glacial origin for cave rhythmite during MIS 5d-c in a glaciokarst landscape, Picos de Europa (Spain)

    Science.gov (United States)

    Ballesteros, Daniel; Jiménez-Sánchez, Montserrat; Giralt, Santiago; DeFelipe, Irene; García-Sansegundo, Joaquín

    2017-06-01

    Laminated slackwater deposits have been identified in many karst caves related to fluvial and lacustrine sedimentation. However, sedimentological evidence rarely supports a glacial origin for these deposits, which was proposed by previous studies. The Torca La Texa shaft is located in a glaciokarst area that comprises numerous slackwater-type deposits, piled up in fining-upward sequences. A basal sandy erosive layer and millimeter-sized laminated rhythmite with interbedded flowstone characterize these sequences. Fining-upward layers of carbonate silt, clay, and minor quartz sand deposited in flooded conduits define the rhythmite lamination. The presence of allochthonous minerals indicates that the rhythmite sediment comes from the glacial erosion of nearby carbonate mountains. Two 234U/230Th radiometric ages dated the rhythmite deposits around 109 and 95 ka, coinciding with relative cold periods included in the MIS 5d-c. These cold periods were marked by a high annual seasonality, immediately after the glacial local maximum extension, in agreement with a varve-type deposit. The combination of these sedimentological mineralogical, geomorphological and paleoclimate information indicates that the rhythmite should be introduced into the studied cave during the summer melting of the glaciers, which produced the recharge of the karst aquifer, triggering cave floods. In addition, punctual glacier collapses would also have their imprint in the slackwater sequences with thicker, coarser and erosive sand deposits and the spring blocking by glaciers may have promoted floods inside the cave. Therefore, the studied rhythmite can be interpreted as glacial varves decanted during the relatively cold climate conditions.

  7. Structures of the dehydrogenation products of methane activation by 5d transition metal cations revisited: Deuterium labeling and rotational contours

    Science.gov (United States)

    Owen, Cameron J.; Boles, Georgia C.; Chernyy, Valeriy; Bakker, Joost M.; Armentrout, P. B.

    2018-01-01

    A previous infrared multiple photon dissociation (IRMPD) action spectroscopy and density functional theory (DFT) study explored the structures of the [M,C,2H]+ products formed by dehydrogenation of methane by four, gas-phase 5d transition metal cations (M+ = Ta+, W+, Ir+, and Pt+). Complicating the analysis of these spectra for Ir and Pt was observation of an extra band in both spectra, not readily identified as a fundamental vibration. In an attempt to validate the assignment of these additional peaks, the present work examines the gas phase [M,C,2D]+ products of the same four metal ions formed by reaction with perdeuterated methane (CD4). As before, metal cations are formed in a laser ablation source and react with methane pulsed into a reaction channel downstream, and the resulting products are spectroscopically characterized through photofragmentation using the free-electron laser for intracavity experiments in the 350-1800 cm-1 range. Photofragmentation was monitored by the loss of D for [Ta,C,2D]+ and [W,C,2D]+ and of D2 in the case of [Pt,C,2D]+ and [Ir,C,2D]+. Comparison of the experimental spectra and DFT calculated spectra leads to structural assignments for all [M,C,2H/2D]+ systems that are consistent with previous identifications and allows a full description of the systematic spectroscopic shifts observed for deuterium labeling of these complexes, some of the smallest systems to be studied using IRMPD action spectroscopy. Further, full rotational contours are simulated for each vibrational band and explain several observations in the present spectra, such as doublet structures in several bands as well as the observed linewidths. The prominent extra bands in the [Pt,C,2D/2H]+ spectra appear to be most consistent with an overtone of the out-of-plane bending vibration of the metal carbene cation structure.

  8. Student science enrichment training program

    Energy Technology Data Exchange (ETDEWEB)

    Sandhu, S.S.

    1994-08-01

    This is a report on the Student Science Enrichment Training Program, with special emphasis on chemical and computer science fields. The residential summer session was held at the campus of Claflin College, Orangeburg, SC, for six weeks during 1993 summer, to run concomitantly with the college`s summer school. Fifty participants selected for this program, included high school sophomores, juniors and seniors. The students came from rural South Carolina and adjoining states which, presently, have limited science and computer science facilities. The program focused on high ability minority students, with high potential for science engineering and mathematical careers. The major objective was to increase the pool of well qualified college entering minority students who would elect to go into science, engineering and mathematical careers. The Division of Natural Sciences and Mathematics and engineering at Claflin College received major benefits from this program as it helped them to expand the Departments of Chemistry, Engineering, Mathematics and Computer Science as a result of additional enrollment. It also established an expanded pool of well qualified minority science and mathematics graduates, which were recruited by the federal agencies and private corporations, visiting Claflin College Campus. Department of Energy`s relationship with Claflin College increased the public awareness of energy related job opportunities in the public and private sectors.

  9. 75 FR 52996 - Areva Enrichment Services, LLC (Eagle Rock Enrichment Facility); Notice of Atomic Safety and...

    Science.gov (United States)

    2010-08-30

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Areva Enrichment Services, LLC (Eagle Rock Enrichment Facility); Notice of Atomic Safety and... Board (Board) in the above-captioned Areva Enrichment Services proceeding is hereby reconstituted by...

  10. 76 FR 387 - Atomic Safety and Licensing Board; AREVA Enrichment Services, LLC (Eagle Rock Enrichment Facility)

    Science.gov (United States)

    2011-01-04

    ... COMMISSION Atomic Safety and Licensing Board; AREVA Enrichment Services, LLC (Eagle Rock Enrichment Facility... Eagle Rock Enrichment Facility (EREF)--in Bonneville County, Idaho; and (2) the receipt, possession, use... site at http://www.nrc.gov/materials/fuel-cycle-fac/arevanc.html . These and other documents relating...

  11. 76 FR 53494 - In the Matter of United States Enrichment Corporation; Paducah Gaseous Enrichment Plant...

    Science.gov (United States)

    2011-08-26

    ... COMMISSION In the Matter of United States Enrichment Corporation; Paducah Gaseous Enrichment Plant; Confirmatory Order (Effective Immediately) I The United States Enrichment Corporation (USEC), a subsidiary of USEC Inc., is the holder of the United States Nuclear Regulatory Commission (NRC or the Commission...

  12. Cross-sectional validity of the EQ-5D-Y as a generic health outcome instrument in children and adolescents with cystic fibrosis in Germany

    Directory of Open Access Journals (Sweden)

    Mittendorf Thomas

    2009-08-01

    Full Text Available Abstract Background Quality of life is recognized as an important additional outcome measure in clinical trials and health economic evaluations. The EQ-5D is an important generic health outcome instrument often used for economic evaluations as a complement with disease-specific outcome measures. In this study quality of life data was assessed using the EQ-5D-Y (new EQ-5D version for children and adolescents and the Cystic Fibrosis Questionnaire (CFQ. The objective of the study is to evaluate the cross-sectional validity of the EQ-5D-Y as a generic health outcome instrument in children and adolescents with cystic fibrosis in Germany. Methods In 2006 a multi-centre study was conducted in four cystic fibrosis centres in Germany. Quality of life data from 96 patients between eight and seventeen years was collected using the EQ-5D-Y as a generic outcome instrument and the Cystic Fibrosis Questionnaire (CFQ as a disease-specific instrument. Results of both instruments were compared by statistical analyses using Spearman's rank correlations. Results 44.6% of the patients stated that they had no problems in any of the EQ-5D-Y dimensions. Several low to high correlations between separate dimensions and the visual analogue scale of the EQ-5D-Y and the different scales of the CFQ for children, their parents and adolescents can be presented in this paper. Looking at the five EQ-5D-Y dimensions the highest correlation (rS = 0.625, p = 0.01 was found between the dimension 'mobility' and the CFQ scale 'physical functioning' in adolescent patients. The overall highest correlation was found between the 'subjective health perception' and the visual analogue scale (rS = 0.744, p = 0.01 in adolescent patients older than 13 years. Conclusion The EQ-5D-Y can be considered a cross-sectional valid generic health outcome instrument which reflects differences in health according to the progression of the life-long chronic disease cystic fibrosis.

  13. 21 CFR 137.350 - Enriched rice.

    Science.gov (United States)

    2010-04-01

    ... 1,000 milligrams of calcium (Ca). Calcium carbonate derived from the use of this substance in milling rice, when present in quantities that furnish less than 500 milligrams of calcium (Ca) per pound... enriched rice unless such enriched rice is labeled to show it contains the optional ingredient calcium...

  14. Inoculation Stress Hypothesis of Environmental Enrichment

    Science.gov (United States)

    Crofton, Elizabeth J.; Zhang, Yafang; Green, Thomas A.

    2014-01-01

    One hallmark of psychiatric conditions is the vast continuum of individual differences in susceptibility vs. resilience resulting from the interaction of genetic and environmental factors. The environmental enrichment paradigm is an animal model that is useful for studying a range of psychiatric conditions, including protective phenotypes in addiction and depression models. The major question is how environmental enrichment, a non-drug and non-surgical manipulation, can produce such robust individual differences in such a wide range of behaviors. This paper draws from a variety of published sources to outline a coherent hypothesis of inoculation stress as a factor producing the protective enrichment phenotypes. The basic tenet suggests that chronic mild stress from living in a complex environment and interacting non-aggressively with conspecifics can inoculate enriched rats against subsequent stressors and/or drugs of abuse. This paper reviews the enrichment phenotypes, mulls the fundamental nature of environmental enrichment vs. isolation, discusses the most appropriate control for environmental enrichment, and challenges the idea that cortisol/corticosterone equals stress. The intent of the inoculation stress hypothesis of environmental enrichment is to provide a scaffold with which to build testable hypotheses for the elucidation of the molecular mechanisms underlying these protective phenotypes and thus provide new therapeutic targets to treat psychiatric/neurological conditions. PMID:25449533

  15. Enrichment Monitor for 235U Fuel Tubes

    Energy Technology Data Exchange (ETDEWEB)

    Winn, W.G.

    2001-08-22

    This report describes the performance of this prototype y-monitor of 235 Uranium enrichment. In this proposed method y-rates associated with 235U and 232U are correlated with enrichment. Instrumentation for appraising fuel tubes with this method has been assembled and tested.

  16. How does resource supply affect evolutionary diversification?

    Science.gov (United States)

    Hall, Alex R; Colegrave, Nick

    2006-01-01

    The availability of different resources in the environment can affect the outcomes of evolutionary diversification. A unimodal distribution of diversity with resource supply has been widely observed and explained previously in the context of selection acting in a spatially heterogeneous environment. Here, we propose an alternative mechanism to explain the relationship between resource supply and diversification that is based on selection for exploitation of different resources. To test this mechanism, we conducted a selection experiment using the bacterium Pseudomonas fluorescens in spatially homogeneous environments over a wide range of resource supply rates. Our results show that niche diversification peaks at intermediate levels of resource availability. We suggest that this unimodal relationship is due to evolutionary diversification that is driven by competition for resources but constrained by the ecological opportunity represented by different resource types. These processes may underlie some general patterns of diversity, including latitudinal gradients in species richness and the effects of anthropogenic enrichment of the environment. PMID:17015335

  17. Validity and reliability of the Urdu version of the 5D itching scale to assess pruritus among patients with chronic kidney disease in Pakistan.

    Science.gov (United States)

    Rehman, Inayat Ur; Khan, Tahir Mehmood

    2017-10-02

    Chronic kidney disease (CKD) has become a major public health issue worldwide in the past few years. Pruritus is a common, well-recognized complication often seen in patients with chronic renal failure. For assessment of pruritus, different tools are used but these tools are unable to identify the changes and variations in the severity of pruritus. The aim of our study was to validate the Urdu-version of the Urdu-version of the 5D itch scale among patients suffering from chronic kidney disease in Pakistan. The 5D itch scale was translated from English into Urdu following translation guidelines for translation. Face and content validity was determined by a panel of experts and piloted. For retest, the Urdu version of the 5D itch scale was administered at baseline and two weeks. A total of 50 participants with end stage renal disease were recruited, and of these, 64% were males. Exploratory factor analysis revealed that the 5D-IS had 2-factor loadings: "Pattern and activity" and "Distribution" with Kaiser-Mayer-Olkin (KMO) = 0.802, Bartlett's test of sphericity was significant (df = 28, p Urdu version of the 5D itch scale was found to be a valid and reliable instrument for assessing pruritus and its severity in patients with chronic kidney disease in Pakistan.

  18. Review of environmental enrichment for broiler chickens

    DEFF Research Database (Denmark)

    Riber, Anja Brinch; Van de Weerd, H.A.; de Jong, I.C.

    2018-01-01

    and welfare of the different kinds of environmental enrichments in the production of broilers that have been described in the scientific literature. Environmental enrichment is defined as an improvement of the environment of captive animals, which increases the behavioral opportunities of the animal and leads...... to improvements of the biological function. This definition has been broadened to include practical and economic aspects, as any enrichment strategy that adversely affects the health of animals or that has too many economic or practical constraints will never be implemented on commercial farms and thus never...... benefit animals. Environmental enrichment for broilers often has the purpose of satisfying behavioral needs and/or stimulating the broilers to an increased level of activity, which among others will reduce the occurrence of leg problems. Potentially successful environmental enrichments for broiler...

  19. Enrichment of high ammonia tolerant methanogenic culture

    DEFF Research Database (Denmark)

    Fotidis, Ioannis; Karakashev, Dimitar Borisov; Proietti, Nicolas

    of the current study was to isolate and identify methanogenic cultures tolerant to high ammonia concentrations. A mixed methanogenic population was stepwise exposed to ammonia concentrations (1 to 9.26 g NH4+-N L-1) during an enrichment process with successive batch cultivations. The methanogenic population...... microbial community composition. The outcome of the enrichment process was a mesophilic aceticlastic methanogenic enriched culture able to withstand high ammonia loads and utilize acetate and form methane stoichiometrically. FISH analysis showed that the methanogens of the enriched culture belonged...... exclusively to strict aceticlastic methanogens. Results obtained in this study, demonstrated for the first time that strictly aceticlastic methanogens, derived from an enriched culture, can efficiently produce methane under high ammonia levels....

  20. Enriching an effect calculus with linear types

    DEFF Research Database (Denmark)

    Egger, Jeff; Møgelberg, Rasmus Ejlers; Simpson, Alex

    2009-01-01

    We define an ``enriched effect calculus'' by conservatively extending  a type theory for computational effects with primitives from linear logic. By doing so, we obtain a generalisation of linear type theory, intended as a formalism for expressing linear aspects of effects. As a worked example, we...... formulate  linearly-used continuations in the enriched effect calculus. These are captured by a fundamental translation of the enriched effect calculus into itself, which extends existing call-by-value and call-by-name linearly-used CPS translations. We show that our translation is involutive. Full...... completeness results for the various linearly-used CPS translations  follow. Our main results, the conservativity of enriching the effect calculus with linear primitives, and the involution property of the fundamental translation, are proved using a category-theoretic semantics for the enriched effect calculus...

  1. Sequential multiple assignment randomization trials with enrichment design.

    Science.gov (United States)

    Liu, Ying; Wang, Yuanjia; Zeng, Donglin

    2017-06-01

    Sequential multiple assignment randomization trial (SMART) is a powerful design to study Dynamic Treatment Regimes (DTRs) and allows causal comparisons of DTRs. To handle practical challenges of SMART, we propose a SMART with Enrichment (SMARTER) design, which performs stage-wise enrichment for SMART. SMARTER can improve design efficiency, shorten the recruitment period, and partially reduce trial duration to make SMART more practical with limited time and resource. Specifically, at each subsequent stage of a SMART, we enrich the study sample with new patients who have received previous stages' treatments in a naturalistic fashion without randomization, and only randomize them among the current stage treatment options. One extreme case of the SMARTER is to synthesize separate independent single-stage randomized trials with patients who have received previous stage treatments. We show data from SMARTER allows for unbiased estimation of DTRs as SMART does under certain assumptions. Furthermore, we show analytically that the efficiency gain of the new design over SMART can be significant especially when the dropout rate is high. Lastly, extensive simulation studies are performed to demonstrate performance of SMARTER design, and sample size estimation in a scenario informed by real data from a SMART study is presented. © 2016, The International Biometric Society.

  2. [Psychoeducational intervention in high ability: intellectual functioning and extracurricular enrichment].

    Science.gov (United States)

    Sastre-Riba, Sylvia

    2014-02-24

    The 'new paradigm' defines the high intellectual ability as a potential that should crystallize progressively throughout development. Its main feature is a high intellectual initial multidimensional potential, which is transformed so that, being a person with high intellectual ability is the result of a developmental process from a neurobiological substrate and the incidence of variables (psychosocial and education) which determines its manifestation more or less stable and optimal to excellence. It is interesting to know the effectiveness of psychoeducational intervention of the extracurricular enrichment programs and their effects on the expression of differential functioning and the optimization of the management of cognitive resources that lead to excellence. An extracurricular enrichment program is described and evaluated through: 1) the stability of the intellectual measures; 2) the satisfaction level of participants and families. Participants are 58 high ability students on the enrichment program and 25 parents. Intellectual profiles are obtained on T1-T2 and calculated their stability by regression analysis, the CSA and CSA-P questionnaires were applied in order to know the participants and families' satisfaction measure. Results show the basic stability of intellectual profiles with five cases of instability among the 58 profiles obtained, and a high satisfaction with the results obtained in the domain of cognitive and personal management among the participants.

  3. COFECO: composite function annotation enriched by protein complex data.

    Science.gov (United States)

    Sun, Choong-Hyun; Kim, Min-Sung; Han, Youngwoong; Yi, Gwan-Su

    2009-07-01

    COFECO is a web-based tool for a composite annotation of protein complexes, KEGG pathways and Gene Ontology (GO) terms within a class of genes and their orthologs under study. Widely used functional enrichment tools using GO and KEGG pathways create large list of annotations that make it difficult to derive consolidated information and often include over-generalized terms. The interrelationship of annotation terms can be more clearly delineated by integrating the information of physically interacting proteins with biological pathways and GO terms. COFECO has the following advanced characteristics: (i) The composite annotation sets of correlated functions and cellular processes for a given gene set can be identified in a more comprehensive and specified way by the employment of protein complex data together with GO and KEGG pathways as annotation resources. (ii) Orthology based integrative annotations among different species complement the defective annotations in an individual genome and provide the information of evolutionary conserved correlations. (iii) A term filtering feature enables users to collect the specified annotations enriched with selected function terms. (iv) A cross-comparison of annotation results between two different datasets is possible. In addition, COFECO provides a web-based GO hierarchical viewer and KEGG pathway viewer where the enrichment results can be summarized and further explored. COFECO is freely accessible at http://piech.kaist.ac.kr/cofeco.

  4. Imaging and 2.5D Modeling of Receiver Functions from Deep Virtual Receivers in Kyushu Island, Japan

    Science.gov (United States)

    Takenaka, H.; Ueda, T.; Murakoshi, T.; Okamoto, T.

    2014-12-01

    . (2013, JGR), while, to our knowledge, the former type IM have been imaged by us for the first time. We further model some SWVRF sections by the 2.5D finite-difference method [Takenaka and Okamoto, 2012, InTech]: we confirm that the assumed depths of Moho and sill-like low velocity zones in the simulation model are well reproduced in the simulated RF imaging results.

  5. Deuterium enrichment of interstellar dusts

    Science.gov (United States)

    Das, Ankan; Chakrabarti, Sandip Kumar; Majumdar, Liton; Sahu, Dipen

    2016-07-01

    High abundance of some abundant and simple interstellar species could be explained by considering the chemistry that occurs on interstellar dusts. Because of its simplicity, the rate equation method is widely used to study the surface chemistry. However, because the recombination efficiency for the formation of any surface species is highly dependent on various physical and chemical parameters, the Monte Carlo method is best suited for addressing the randomness of the processes. We carry out Monte-Carlo simulation to study deuterium enrichment of interstellar grain mantle under various physical conditions. Based on the physical properties, various types of clouds are considered. We find that in diffuse cloud regions, very strong radiation fields persists and hardly a few layers of surface species are formed. In translucent cloud regions with a moderate radiation field, significant number of layers would be produced and surface coverage is mainly dominated by photo-dissociation products such as, C, CH_3, CH_2D, OH and OD. In the intermediate dense cloud regions (having number density of total hydrogen nuclei in all forms ˜2 × 10^4 cm^{-3}), water and methanol along with their deuterated derivatives are efficiently formed. For much higher density regions (˜10^6 cm^{-3}), water and methanol productions are suppressed but surface coverage of CO, CO_2, O_2, O_3 are dramatically increased. We find a very high degree of fractionation of water and methanol. Observational results support a high fractionation of methanol but surprisingly water fractionation is found to be low. This is in contradiction with our model results indicating alternative routes for de-fractionation of water.

  6. Can the anxiety domain of EQ-5D and mental health items from SF-36 help predict outcomes after surgery for lumbar degenerative disorders?

    Science.gov (United States)

    Carreon, Leah Y; Djurasovic, Mladen; Dimar, John R; Owens, R Kirk; Crawford, Charles H; Puno, Rolando M; Bratcher, Kelly R; McGraw, Katlyn E; Glassman, Steven D

    2016-09-01

    OBJECTIVE Studies have shown that anxious or depressed patients may have poorer outcomes after lumbar fusion. These conclusions were drawn from questionnaires specifically designed to measure anxiety and depression. The objective of this study is to determine if responses to the EQ-5D anxiety/depression domain or the items used to calculate the 36-Item Short-Form Health Survey (SF-36) Mental Component Summary (MCS) can predict outcomes after lumbar fusion surgery. METHODS Patients enrolled in the National Neurosurgery Quality and Outcomes Database from a single center with 1-year follow-up were identified. The outcomes collected include the Oswestry Disability Index (ODI), EQ-5D, SF-36, and the back- and leg-pain numeric rating scales (range 0-10). Linear regression modeling was performed to predict the 1-year ODI scores using the EQ-5D anxiety/depression domain and the 14 items used to calculate SF-36 MCS. RESULTS Complete data were available for 312 (88%) of 353 eligible patients. The mean patient age was 58.5 years, 175 (56%) patients were women, and 52 patients were smokers. After controlling for other factors, the item in the SF-36 that asks "Have you felt downhearted and depressed?" is the strongest predictor of the 1-year ODI score (r(2) = 0.191; p = 0.000) and 1-year EQ-5D score (r(2) = 0.205; p = 0.000). Neither the EQ-5D anxiety/depression domain nor the diagnoses of anxiety or depression were predictors of 1-year outcomes. CONCLUSIONS Patient responses to SF-36 item "Have you felt downhearted and depressed?" account for 20% of the variability of the 1-year ODI and EQ-5D scores and can be used by clinicians to screen for anxiety or depression in patients prior to lumbar fusion surgery. Clinicians may offer psychological support to these patients preoperatively in order to improve treatment outcomes.

  7. Parent-child discrepancy in the assessment of health- related quality of life using the EQ-5D-Y questionnaire.

    Science.gov (United States)

    Perez Sousa, Miguel Á; Olivares Sánchez-Toledo, Pedro R; Gusi Fuerte, Narcis

    2017-12-01

    The assessment of health-related quality of life (HRQoL) serves to detect changes over time in patients' health status and allows to do a cost-effectiveness analysis of treatments. When children with special health features cannot perform a self-assessment, it is possible to assess their HRQoL through their parents or caregivers. To date, the discrepancy in the assessment of HRQoL using the EQ-5D-Y questionnaire among children with cerebral palsy (CP) and their parents has not been analyzed. The objective of this study was to analyze the level of agreement in the HRQoL assessment using the EQ-5D-Y questionnaire and its proxy version among children with CP and their parents or caregivers. Children and adolescents with CP, and their parents, from a special education school in the region of Extremadura (Spain) participated in the study. The EQ-5D-Y questionnaire was used for children and the EQ-5D-Y proxy version, for parents. Interviews were conducted in the first quarter of 2015. The level of agreement in the responses was analyzed using the Cohen's kappa coefficient for the five domains of the EQ-5D-Y and the intraclass correlation coefficient for the visual analogue scale. Sixty-two children with CP and mild and/or moderate functional capacity impairment, and their parents, participated in the study. The level of agreement was poor in the HRQoL assessment between children and parents in all the questionnaire domains ( parent-child disagreement was observed in the HRQoL assessment in the population with CP using the EQ-5D-Y questionnaire.

  8. Determination and modeling the optimum conditions of beta glucanase Bacillus subtilis B5d activity with potential used as feed additive

    Directory of Open Access Journals (Sweden)

    Sholeh Dahpahlevan

    2016-06-01

    Full Text Available Introduction: Microbial β - 1, 4 glucanase is one of the key enzymes in glucan hydrolysis. Among bacteria, Bacillus species is a main source for industrial glucanse production. According to interaction between environmental factors on the enzymatic catalytic properties, in this study the potential of β-glucanase production by native strain B. subtilis B5d isolated from apple phyllosphere orchards and determination and modeling the optimum conditions of enzyme activity was surveyed. Materials and methods: In this study, the potential of β-glucanase production by B. subtilis B5d was confirmed using qualitative method. The B. subtilis B5d isolate was identified through biochemical and molecular methods. Determination of optimum condition for beta glucanase activity was evaluated by response surface method and Central Composite Design. Investigated variables included temperature (20- 80 °C, pH (3.5- 8 and concentration of substrate (0.1- 1%. Results: According to the molecular and biochemical analysis, the strain B. subtilis B5d belonges to B.subtilis species. Based on the Central Composite Design results, the quadratic model was the most suitable model for predicting β-glucanase activity in experimental temperature, pH and substrate concentration range. Furthermore, the optimization of enzyme activity showed that the β-glucanase produced by strain B5d has highest catalytic activity at pH (5.5- 7 and temperature (50- 65°C and the high concentration of lechinan. However, the enzyme activity is reduced in 80 and 20 °C as well as low concentration of substrate. Validation test of the prediction model of optimization obtained by response surface methodology showed a good agreement between experimental and predicted data. Discussion and conclusion: According to the optimum catalytic characteristics, the β-glucanase produced by B. subtilis B5d has a potential to be used as a feed additive.

  9. Comparison of EQ-5D-5L health state utilities using four country-specific tariffs on a breast cancer patient sample in mainland China.

    Science.gov (United States)

    Liu, Liu; Li, Shunping; Wang, Min; Chen, Gang

    2017-01-01

    The objective of this study was to compare the differences in the five-level EuroQol-5 dimensions (EQ-5D-5L) health state utility scores derived from Chinese, Japanese, Korean, and UK tariffs. Six hundred and twenty-one breast cancer patients were invited for a face-to-face interview in Qingdao Municipal Hospital, China. EQ-5D-5L was scored using tariffs from China, Japan, Korea, and the UK. The null hypothesis of normal distribution of the EQ-5D-5L utility score was tested by the Shapiro-Wilk test. Nonparametric Friedman test and Wilcoxon signed-rank test were used to determine the difference among the four tariffs. The intraclass correlation coefficients (ICCs) and Bland-Altman plots were used to study the agreement among the four EQ-5D-5L scores. Known-groups validity was studied using a regression framework. There were 608 participants in the final analysis, with a mean ± standard deviation (SD) age of 48.0±9.6 years. EQ-5D-5L utility scores were non-normally distributed. The means (median) ± SD of EQ-5D-5L utilities derived from Chinese, Japanese, Korean, and UK tariffs were 0.828 (0.879) ±0.184, 0.802 (0.823) ±0.164, 0.831 (0.829) ±0.137, and 0.838 (0.866) ±0.154, respectively. Among pairwise comparisons, the difference of median EQ-5D-5L utility scores was only insignificant between Chinese and UK tariffs. Excellent agreements (with ICCs >0.9) were found among the four tariffs albeit the limits of agreement between each pair of tariffs were wide. Known-groups validity was supported. Although four country-specific EQ-5D-5L tariffs have shown an overall high level of correlation and agreement, none of them could be regarded as interchangeable. The higher correlation and agreement between Chinese and UK tariffs may be due to the similar functions that were used in the tariff development. In the absence of Chinese-specific tariff, the UK tariff is the second-best option to be applied in the Chinese population. Results of this study further contribute to

  10. Stochastic emergence of inflaton fluctuations in a SdS primordial universe with large-scale repulsive gravity from a 5D vacuum

    OpenAIRE

    Reyes, Luz Marina; Aguilar, Jose Edgar Madriz; Bellini, Mauricio

    2010-01-01

    We develop a stochastic approach to study scalar field fluctuations of the inflaton field in an early inflationary universe with a black-hole (BH), which is described by an effective 4D SdS metric. Considering a 5D Ricci-flat SdS static metric, we implement a planar coordinate transformation, in order to obtain a 5D cosmological metric, from which the effective 4D SdS metric can be induced on a 4D hypersurface. We found that at the end of inflation, the squared fluctuations of the inflaton fi...

  11. The novel desmopressin analogue [V4Q5]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models

    Science.gov (United States)

    GARONA, JUAN; PIFANO, MARINA; ORLANDO, ULISES D.; PASTRIAN, MARIA B.; IANNUCCI, NANCY B.; ORTEGA, HUGO H.; PODESTA, ERNESTO J.; GOMEZ, DANIEL E.; RIPOLL, GISELLE V.; ALONSO, DANIEL F.

    2015-01-01

    Desmopressin (dDAVP) is a safe haemostatic agent with previously reported antitumour activity. It acts as a selective agonist for the V2 vasopressin membrane receptor (V2r) present on tumour cells and microvasculature. The purpose of this study was to evaluate the novel peptide derivative [V4Q5]dDAVP in V2r-expressing preclinical mouse models of breast cancer. We assessed antitumour effects of [V4Q5]dDAVP using human MCF-7 and MDA-MB-231 breast carcinoma cells, as well as the highly metastatic mouse F3II cell line. Effect on in vitro cancer cell growth was evaluated by cell proliferation and clonogenic assays. Cell cycle distribution was analysed by flow cytometry. In order to study the effect of intravenously administered [V4Q5]dDAVP on tumour growth and angiogenesis, breast cancer xenografts were generated in athymic mice. F3II cells were injected into syngeneic mice to evaluate the effect of [V4Q5]dDAVP on spontaneous and experimental metastatic spread. In vitro cytostatic effects of [V4Q5]dDAVP against breast cancer cells were greater than those of dDAVP, and associated with V2r-activated signal transduction and partial cell cycle arrest. In MDA-MB-231 xenografts, [V4Q5]dDAVP (0.3 μg/kg, thrice a week) reduced tumour growth and angiogenesis. Treatment of F3II mammary tumour-bearing immunocompetent mice resulted in complete inhibition of metastatic progression. [V4Q5]dDAVP also displayed greater antimetastatic efficacy than dDAVP on experimental lung colonisation by F3II cells. The novel analogue was well tolerated in preliminary acute toxicology studies, at doses ≥300-fold above that required for anti-angiogenic/antimetastatic effects. Our data establish the preclinical activity of [V4Q5]dDAVP in aggressive breast cancer, providing the rationale for further clinical trials. PMID:25846632

  12. Proyectar con 5 D.I.T.S: análisis del proyecto de arquitectura y del proyecto de diseño.

    OpenAIRE

    Recasens Alsina, Marta

    2012-01-01

    The thesis developed here is entitled ¿Proyectar con 5 D.I.T.S¿ (Designing with 5 D.I.T.S.), and more specifically; ¿Análisis del proyecto de Arquitectura y el proyecto de diseño¿ (analysis of the architecture and design projects). This title corresponds to a simile of the five digits of the hand, which is succinctly an essential metaphor when one is designing: using the five senses. Thus the objective of this thesis is to encourage the exercise of designing with full creative freedom becau...

  13. Synthesis and Antimicrobial Activity of Some New Thiadiazoles, Thioamides, 5-Arylazothiazoles and Pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines

    Directory of Open Access Journals (Sweden)

    Abdou O. Abdelhamid

    2016-08-01

    Full Text Available A novel series of 1,3,4-thiadiazoles, 5-arylazothiazoles and hexahydropyrimido-[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines were synthesized via reaction of hydrazonoyl halides with each of alkyl carbothioates, carbothioamides and 7-thioxo-5,6,7,8-tetrahydropyrimido-[4,5-d]pyrimidine-2,4(1H,3H-diones in the presence of triethylamine. The structures of the newly synthesized compounds were established based on their spectral data, elemental analyses and alternative synthetic routes whenever possible. Also, the newly synthesized compounds were screened for their antimicrobial activity against various microorganisms.

  14. 2.5D far-field diffraction tomography inversion scheme for GPR that takes into account the planar air-soil interface

    DEFF Research Database (Denmark)

    Meincke, Peter

    2001-01-01

    A new 2.5D inversion scheme is derived for fixed-offset ground penetrating radar (GPR) that takes into account the planar air-soil interface. The inversion scheme is based upon the first Born approximation and a far-field approximation of the dyadic Green function for a two-layer medium.......A new 2.5D inversion scheme is derived for fixed-offset ground penetrating radar (GPR) that takes into account the planar air-soil interface. The inversion scheme is based upon the first Born approximation and a far-field approximation of the dyadic Green function for a two-layer medium....

  15. The novel desmopressin analogue [V4Q5]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models.

    Science.gov (United States)

    Garona, Juan; Pifano, Marina; Orlando, Ulises D; Pastrian, Maria B; Iannucci, Nancy B; Ortega, Hugo H; Podesta, Ernesto J; Gomez, Daniel E; Ripoll, Giselle V; Alonso, Daniel F

    2015-01-01

    Desmopressin (dDAVP) is a safe haemostatic agent with previously reported antitumour activity. It acts as a selective agonist for the V2 vasopressin membrane receptor (V2r) present on tumour cells and microvasculature. The purpose of this study was to evaluate the novel peptide derivative [V4Q5]dDAVP in V2r-expressing preclinical mouse models of breast cancer. We assessed antitumour effects of [V4Q5]dDAVP using human MCF-7 and MDA-MB-231 breast carcinoma cells, as well as the highly metastatic mouse F3II cell line. Effect on in vitro cancer cell growth was evaluated by cell proliferation and clonogenic assays. Cell cycle distribution was analysed by flow cytometry. In order to study the effect of intravenously administered [V4Q5]dDAVP on tumour growth and angiogenesis, breast cancer xenografts were generated in athymic mice. F3II cells were injected into syngeneic mice to evaluate the effect of [V4Q5]dDAVP on spontaneous and experimental metastatic spread. In vitro cytostatic effects of [V4Q5]dDAVP against breast cancer cells were greater than those of dDAVP, and associated with V2r-activated signal transduction and partial cell cycle arrest. In MDA-MB-231 xenografts, [V4Q5]dDAVP (0.3 µg/kg, thrice a week) reduced tumour growth and angiogenesis. Treatment of F3II mammary tumour-bearing immunocompetent mice resulted in complete inhibition of metastatic progression. [V4Q5]dDAVP also displayed greater antimetastatic efficacy than dDAVP on experimental lung colonisation by F3II cells. The novel analogue was well tolerated in preliminary acute toxicology studies, at doses ≥ 300-fold above that required for anti-angiogenic/antimetastatic effects. Our data establish the preclinical activity of [V4Q5]dDAVP in aggressive breast cancer, providing the rationale for further clinical trials.

  16. Mapping of Multiple Sclerosis Walking Scale (MSWS-12 to five-dimension EuroQol (EQ-5D health outcomes: an independent validation in a randomized control cohort

    Directory of Open Access Journals (Sweden)

    Sidovar MF

    2016-02-01

    Full Text Available Matthew F Sidovar,1 Brendan L Limone,2 Craig I Coleman2 1Clinical Development and Medical Affairs, Acorda Therapeutics, Ardsley, NY, 2Department of Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, CT, USA Background: Mapping of patient-reported outcomes to the five-dimension EuroQol (EQ-5D health index is increasingly being used for understanding the relationship of outcomes to health states and for predicting utilities that have application in economic evaluations. The 12-item Multiple Sclerosis Walking Scale (MSWS-12 is a patient-reported outcome that assesses the impact of walking impairment in people with MS. An equation for mapping the MSWS-12 to the EQ-5D was previously developed and validated using a North American Research Committee on MS (NARCOMS registry cohort. Materials and methods: This analysis retested the validity of the equation mapping the MSWS-12 to the three-level EQ-5D (EQ-5D-3L by using an independent cohort of patients with MS enrolled in a randomized controlled trial. Mapping was evaluated at two separate time points (baseline and week 4 during the clinical trial. The mapping equation’s performance was subsequently assessed with mean absolute error (MAE and root-mean-square error (RMSE by comparing equation-based estimates to values elicited in the trial using the actual EQ-5D-3L questionnaire. Results: The mapping equation predicted EQ-5D-3L values in this external cohort with reasonable precision at both time points (MAE 0.116 and RMSE 0.155 at baseline; MAE 0.105 and RMSE 0.138 at week 4, and was similar to that reported in the original NARCOMS cohort (MAE 0.109 and RMSE 0.145. Also as observed in the original NARCOMS cohort, the mapping equation performed best in patients with EQ-5D-3L values between 0.50 and 0.75, and poorly in patients with values <0.50.Conclusion: The mapping equation performed similarly in this external cohort as in the original derivation cohort, including a poorer

  17. Resource Mobilization

    International Development Research Centre (IDRC) Digital Library (Canada)

    This practical guidebook supports and promotes new and creative thinking on resource mobilization for ... sources and come up with creative resource mobilization strategies to ensure survival. The Importance of ...... funds had already been earmarked for buying new classroom facilities. Maintain integrity of auction. 2.

  18. Mineral resources

    NARCIS (Netherlands)

    Henckens, M.L.C.M.; Ierland, van E.C.; Driessen, P.P.J.; Worrell, E.

    2016-01-01

    The extractable ores of the world's geologically scarcest mineral resources (e.g. antimony, molybdenum and zinc) may be exhausted within several decades to a century, if their extraction continues to increase. This paper explores the likelihood that these scarce mineral resources can be conserved

  19. How Can Digital Personal(Ized) Books Enrich the Language Arts Curriculum?

    Science.gov (United States)

    Kucirkova, Natalia

    2017-01-01

    Digital personal(ized) books are a relatively recent addition to the rich repertoire of literacy resources available to pre-K and elementary school teachers. This article summarizes the key ways in which personal(ized) books can enrich the language arts curriculum, drawing on a series of empirically based examples. The value of personalization in…

  20. Water Quality: Water Education for Teachers. A 4-H School Enrichment Program.

    Science.gov (United States)

    Powell, G. Morgan; Kling, Emily B.

    This looseleaf notebook is a teacher resource package that is designed for enrichment program use. It contains five units dealing with water quality: (1) The Water Cycle; (2) Our Water Supply; (3) Waste/Water Treatment; (4) Water Conservation; (5) Water Pollution. The units provide background information, experiments, stories, poems, plays, and…

  1. NEAT: an efficient network enrichment analysis test.

    Science.gov (United States)

    Signorelli, Mirko; Vinciotti, Veronica; Wit, Ernst C

    2016-09-05

    Network enrichment analysis is a powerful method, which allows to integrate gene enrichment analysis with the information on relationships between genes that is provided by gene networks. Existing tests for network enrichment analysis deal only with undirected networks, they can be computationally slow and are based on normality assumptions. We propose NEAT, a test for network enrichment analysis. The test is based on the hypergeometric distribution, which naturally arises as the null distribution in this context. NEAT can be applied not only to undirected, but to directed and partially directed networks as well. Our simulations indicate that NEAT is considerably faster than alternative resampling-based methods, and that its capacity to detect enrichments is at least as good as the one of alternative tests. We discuss applications of NEAT to network analyses in yeast by testing for enrichment of the Environmental Stress Response target gene set with GO Slim and KEGG functional gene sets, and also by inspecting associations between functional sets themselves. NEAT is a flexible and efficient test for network enrichment analysis that aims to overcome some limitations of existing resampling-based tests. The method is implemented in the R package neat, which can be freely downloaded from CRAN ( https://cran.r-project.org/package=neat ).

  2. Enriching and improving the quality of linked data with GIS

    Directory of Open Access Journals (Sweden)

    Iwaniak Adam

    2016-06-01

    Full Text Available Standardization of methods for data exchange in GIS has along history predating the creation of World Wide Web. The advent of World Wide Web brought the emergence of new solutions for data exchange and sharing including; more recently, standards proposed by the W3C for data exchange involving Semantic Web technologies and linked data. Despite the growing interest in integration, GIS and linked data are still two separate paradigms for describing and publishing spatial data on the Web. At the same time, both paradigms offer complementary ways of representing real world phenomena and means of analysis using different processing functions. The complementarity of linked data and GIS can be leveraged to synergize both paradigms resulting in richer data content and more powerful inferencing. The article presents an approach aimed at integrating linked data with GIS. The approach relies on the use of GIS tools for integration, verification and enrichment of linked data. The GIS tools are employed to enrich linked data by furnishing access to collection of data resources, defining relationship between data resources, and subsequently facilitating GIS data integration with linked data. The proposed approach is demonstrated with examples using data from DBpedia, OSM, and tools developed by the authors for standard GIS software.

  3. Training versus engagement as paths to cognitive enrichment with aging.

    Science.gov (United States)

    Stine-Morrow, Elizabeth A L; Payne, Brennan R; Roberts, Brent W; Kramer, Arthur F; Morrow, Daniel G; Payne, Laura; Hill, Patrick L; Jackson, Joshua J; Gao, Xuefei; Noh, Soo Rim; Janke, Megan C; Parisi, Jeanine M

    2014-12-01

    While a training model of cognitive intervention targets the improvement of particular skills through instruction and practice, an engagement model is based on the idea that being embedded in an intellectually and socially complex environment can impact cognition, perhaps even broadly, without explicit instruction. We contrasted these 2 models of cognitive enrichment by randomly assigning healthy older adults to a home-based inductive reasoning training program, a team-based competitive program in creative problem solving, or a wait-list control. As predicted, those in the training condition showed selective improvement in inductive reasoning. Those in the engagement condition, on the other hand, showed selective improvement in divergent thinking, a key ability exercised in creative problem solving. On average, then, both groups appeared to show ability-specific effects. However, moderators of change differed somewhat for those in the engagement and training interventions. Generally, those who started either intervention with a more positive cognitive profile showed more cognitive growth, suggesting that cognitive resources enabled individuals to take advantage of environmental enrichment. Only in the engagement condition did initial levels of openness and social network size moderate intervention effects on cognition, suggesting that comfort with novelty and an ability to manage social resources may be additional factors contributing to the capacity to take advantage of the environmental complexity associated with engagement. Collectively, these findings suggest that training and engagement models may offer alternative routes to cognitive resilience in late life. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  4. Contrafreeloading in grizzly bears: implications for captive foraging enrichment.

    Science.gov (United States)

    McGowan, Ragen T S; Robbins, Charles T; Alldredge, J Richard; Newberry, Ruth C

    2010-01-01

    Although traditional feeding regimens for captive animals were focused on meeting physiological needs to assure good health, more recently emphasis has also been placed on non-nutritive aspects of feeding. The provision of foraging materials to diversify feeding behavior is a common practice in zoos but selective consumption of foraging enrichment items over more balanced "chow" diets could lead to nutrient imbalance. One alternative is to provide balanced diets in a contrafreeloading paradigm. Contrafreeloading occurs when animals choose resources that require effort to exploit when identical resources are freely available. To investigate contrafreeloading and its potential as a theoretical foundation for foraging enrichment, we conducted two experiments with captive grizzly bears (Ursus arctos horribilis). In Experiment 1, bears were presented with five foraging choices simultaneously: apples, apples in ice, salmon, salmon in ice, and plain ice under two levels of food restriction. Two measures of contrafreeloading were considered: weight of earned food consumed and time spent working for earned food. More free than earned food was eaten, with only two bears consuming food extracted from ice, but all bears spent more time manipulating ice containing salmon or apples than plain ice regardless of level of food restriction. In Experiment 2, food-restricted bears were presented with three foraging choices simultaneously: apples, apples inside a box, and an empty box. Although they ate more free than earned food, five bears consumed food from boxes and all spent more time manipulating boxes containing apples than empty boxes. Our findings support the provision of contrafreeloading opportunities as a foraging enrichment strategy for captive wildlife. (c) 2009 Wiley-Liss, Inc.

  5. Profile of World Uranium Enrichment Programs - 2007

    Energy Technology Data Exchange (ETDEWEB)

    Laughter, Mark D [ORNL

    2007-11-01

    It is generally agreed that the most difficult step in building a nuclear weapon is acquiring weapons grade fissile material, either plutonium or highly enriched uranium (HEU). Plutonium is produced in a nuclear reactor, while HEU is produced using a uranium enrichment process. Enrichment is also an important step in the civil nuclear fuel cycle, in producing low enriched uranium (LEU) for use in fuel for nuclear reactors. However, the same equipment used to produce LEU for nuclear fuel can also be used to produce HEU for weapons. Safeguards at an enrichment plant are the array of assurances and verification techniques that ensure uranium is only enriched to LEU, no undeclared LEU is produced, and no uranium is enriched to HEU or secretly diverted. There are several techniques for enriching uranium. The two most prevalent are gaseous diffusion, which uses older technology and requires a lot of energy, and gas centrifuge separation, which uses more advanced technology and is more energy efficient. Gaseous diffusion plants (GDPs) provide about 40% of current world enrichment capacity, but are being phased out as newer gas centrifuge enrichment plants (GCEPs) are constructed. Estimates of current and future enrichment capacity are always approximate, due to the constant upgrades, expansions, and shutdowns occurring at enrichment plants, largely determined by economic interests. Currently, the world enrichment capacity is approximately 53 million kg-separative work units (SWU) per year, with 22 million in gaseous diffusion and 31 million in gas centrifuge plants. Another 23 million SWU/year of capacity are under construction or planned for the near future, almost entirely using gas centrifuge separation. Other less-efficient techniques have also been used in the past, including electromagnetic and aerodynamic separations, but these are considered obsolete, at least from a commercial perspective. Laser isotope separation shows promise as a possible enrichment technique

  6. Rethinking resources

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, W.L. [Univ. of Texas, Austin, TX (United States)

    1994-09-01

    We class energy and mineral resources as finite because we are reasonably certain that they do not form at a rate remotely approaching man`s rate of use. We have certain environments of the earth that have limits in carrying capacity, and we presume that the global environment does as well. These facts and presumptions, coupled with anxieties over growth in population and consumption, have posed pictures of impending catastrophe from Malthus through the Club of Rome and currently, among certain advocates of what is called sustainable development. To avoid future calamity, command and control management of resource use is urged by many. But, quite simply, such management would presume a wisdom that historical experience suggests does not exist. As a recent example, consider natural gas resources. A decade and a half ago, the resource base of natural gas in the United States was judged to be near exhaustion. Estimates of remaining resources by governmental agencies, academicians, and several major energy companies indicated the ultimate resource would be at about 100 tcf today, with essential depletion by the end of the century. Such was the near universal wisdom that compelled Congress to enact legislation to outright prohibit certain use of natural gas. Today, after nearly eight years of gas supply in excess of demand and with entirely new appreciation of the impact of technology, estimates of the remaining gas resource by industry, government, and others are an order of magnitude greater than those made just 15 yr ago, and the same government that then sought to husband a resource presumed to be near depletion now aggressively promotes its use and consumption. Limits to resources and limits to environmental carrying capacity do indeed exist, but we have yet to define those limits and the paths thereto.

  7. Mineral Resources

    OpenAIRE

    Ababsa, Myriam

    2014-01-01

    Jordan’s natural resources are very limited: water is scarce, there is little arable land and the country has few sources of energy (fig. I.11). Jordan’s mineral industry has a long history: flint was used in prehistoric times and early copper mining started in Wadi Faynan during the Chalcolithic Period. The following is a brief presentation of Jordan’s resources. Mining and investments will be studied in Part 3. Figure I.11 — Jordan Mineral Resources. NRA 2012 Phosphates The Jordanian Natur...

  8. Reverse energy-pooling collisions: K(5D)+Na(3S){r_arrow}K(4P)+Na(3P)

    Energy Technology Data Exchange (ETDEWEB)

    Guldberg-Kjaer, S.; De Filippo, G.; Milosevic, S.; Magnier, S.; Pedersen, J.O. [Niels Bohr Institute, O/rsted Laboratory, Universitetsparken 5, DK-2100, Copenhagen O/ (Denmark); Allegrini, M. [Unita INFM, Dipartimento di Fisica, Universita di Pisa, Piazza Torricelli 2, I--56126, Pisa (Italy)

    1997-04-01

    The observation of a heteronuclear reverse energy pooling process is reported. The cross section for the collision processes K(5D)+Na(3S){r_arrow}K(4P)+Na(3P) has been measured and compared to calculations carried out using a multicrossing Landau-Zener model. {copyright} {ital 1997} {ital The American Physical Society}

  9. Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Ki Hyun; Haitjema, Charles; Liu, Xueqi; Ding, Fran; Wang, Hongwei; DeLisa, Matthew P.; Ke, Ailong (Yale); (Cornell); (Tsinghua)

    2012-10-10

    Clustered regularly interspaced short palindromic repeats (CRISPRs), together with an operon of CRISPR-associated (Cas) proteins, form an RNA-based prokaryotic immune system against exogenous genetic elements. Cas5 family proteins are found in several type I CRISPR-Cas systems. Here, we report the molecular function of subtype I-C/Dvulg Cas5d from Bacillus halodurans. We show that Cas5d cleaves pre-crRNA into unit length by recognizing both the hairpin structure and the 3 single stranded sequence in the CRISPR repeat region. Cas5d structure reveals a ferredoxin domain-based architecture and a catalytic triad formed by Y46, K116, and H117 residues. We further show that after pre-crRNA processing, Cas5d assembles with crRNA, Csd1, and Csd2 proteins to form a multi-sub-unit interference complex similar to Escherichia coli Cascade (CRISPR-associated complex for antiviral defense) in architecture. Our results suggest that formation of a crRNA-presenting Cascade-like complex is likely a common theme among type I CRISPR subtypes.

  10. Large shifts in vegetation and climate during the Early Weichselian (MIS 5d-c) inferred from multi-proxy evidence at Sokli (northern Finland)

    NARCIS (Netherlands)

    Helmens, K.F.; Väliranta, M.; Engels, S.; Shala, S

    2012-01-01

    For decades, detailed studies on Early Weichselian deposits have been made in central Europe. In contrast, these studies are rare in Fennoscandia in northern Europe. We here integrate an extensive multi-proxy data set obtained on sediments of MIS 5d-c age that form part of a long sediment record

  11. Geochemical assessment of fluoride enrichment and nitrate ...

    Indian Academy of Sciences (India)

    62

    , M.P. India. Email- sunil16sster@gmail.com. Abstract-. This systematic study was carried out with objective to delineate the various sources responsible for NO3. - contamination and F- enrichment by utilizing statistical and graphical methods.

  12. Measuring quality of life in opioid-induced constipation: mapping EQ-5D-3 L and PAC-QOL.

    Science.gov (United States)

    Hatswell, Anthony James; Vegter, Stefan

    2016-12-01

    In health economic evaluations, quality of life should be measured with preference-based utilities, such as the EuroQol 5 Dimension 3-level (EQ-5D-3 L). Non-preference-based instruments (often disease-specific questionnaires) are commonly mapped to utilities. We investigated if the relationship observed between the Patient Assessment of Constipation Quality of Life (PAC-QOL) and the EQ-5D-3 L in patients with chronic idiopathic constipation (CIC) also applies in opioid-induced constipation (OIC). EQ-5D-3 L patient-level data from a clinical study of lubiprostone in OIC (n = 439) were scored using the UK tariff. A published mapping between the PAC-QOL and the EQ-5D-3 L was tested using these data. New mapping formulas were analysed, including PAC-QOL total and subscale scores. The root mean square error (RMSE), the adjusted R(2) and predicted/observed plots were used to test the fit. The utility measured with the EQ-5D-3 L was 0.450 ± 0.329, with a distinctly bimodal distribution. This significantly improved if patients responded to treatment (defined as an increase of three spontaneous bowel movements per week, with no rescue medication taken). The published mapping in CIC performed poorly in this OIC population, and the PAC-QOL could not be reliably mapped on to the EQ-5D-3 L even when re-estimating coefficients. This was shown in our two mappings (using PAC-QOL total score, and subscale scores) by a high RMSE (0.317 and 0.314) and a low R(2) (0.068 and 0.080), with high utilities underestimated and low utilities overestimated. Patients with OIC have a low quality of life which does improve with the resolution of symptoms. However the PAC-QOL cannot be used to estimate the EQ-5D-3 L utility - potentially as the PAC-QOL does not capture the all relevant aspects of the patients quality of life (for example the cause of the opioid use).

  13. Challenges when developing omega-3 enriched foods

    OpenAIRE

    JACOBSEN Charlotte

    2010-01-01

    Due to the polyunsaturated nature of omega-3 fatty acids, lipid oxidation is a major challenge when developing omega-3 enriched foods. In multiphase food systems, several factors can affect lipid oxidation and efficacy of antioxidants, added to prevent lipid oxidation. This review discusses the influence of important factors such as oil quality, delivery systems for omega-3 fatty acids, processing conditions, composition of the food matrix on lipid oxidation in different omega-3 enriched food...

  14. Arthritis - resources

    Science.gov (United States)

    Resources - arthritis ... The following organizations provide more information on arthritis : American Academy of Orthopaedic Surgeons -- orthoinfo.aaos.org/menus/arthritis.cfm Arthritis Foundation -- www.arthritis.org Centers for Disease Control and Prevention -- www. ...

  15. Seaweed resources

    Digital Repository Service at National Institute of Oceanography (India)

    Deshmukhe, G.V.; Dhargalkar, V.K.; Untawale, A

    The chapter summarizes our present knowledge of the seaweed resources of the Indian Ocean region with regard to the phytogeographical distribution, composition, biomass, utilization, cultivation, conservation and management. The voluminous data...

  16. Hemophilia - resources

    Science.gov (United States)

    Resources - hemophilia ... The following organizations provide further information on hemophilia : Centers for Disease Control and Prevention -- www.cdc.gov/ncbddd/hemophilia/index.html National Heart, Lung, and Blood Institute -- www.nhlbi.nih.gov/ ...

  17. Depression - resources

    Science.gov (United States)

    Resources - depression ... Depression is a medical condition. If you think you may be depressed, see a health care provider. ... following organizations are good sources of information on depression : American Psychological Association -- www.apa.org/topics/depress/ ...

  18. Diabetes - resources

    Science.gov (United States)

    Resources - diabetes ... The following sites provide further information on diabetes: American Diabetes Association -- www.diabetes.org Juvenile Diabetes Research Foundation International -- www.jdrf.org National Center for Chronic Disease Prevention and Health Promotion -- ...

  19. Forest Resources

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    Forest biomass is an abundant biomass feedstock that complements the conventional forest use of wood for paper and wood materials. It may be utilized for bioenergy production, such as heat and electricity, as well as for biofuels and a variety of bioproducts, such as industrial chemicals, textiles, and other renewable materials. The resources within the 2016 Billion-Ton Report include primary forest resources, which are taken directly from timberland-only forests, removed from the land, and taken to the roadside.

  20. Less Is More: Cross-Validation Testing of Simplified Nonlinear Regression Model Specifications for EQ-5D-5L Health State Values.

    Science.gov (United States)

    Rand-Hendriksen, Kim; Ramos-Goñi, Juan Manuel; Augestad, Liv Ariane; Luo, Nan

    The conventional method for modeling of the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) health state values in national valuation studies is an additive 20-parameter main-effects regression model. Statistical models with many parameters are at increased risk of overfitting-fitting to noise and measurement error, rather than the underlying relationship. To compare the 20-parameter main-effects model to simplified, nonlinear, multiplicative regression models in terms of how accurately they predict mean values of out-of-sample health states. We used data from the Spanish, Singaporean, and Chinese EQ-5D-5L valuation studies. Four models were compared: an 8-parameter model with single parameter per dimension, multiplied by cross-dimensional parameters for levels 2, 3, and 4; 9- and 11-parameter extensions with handling of differences in the wording of level 5; and the "standard" additive 20-parameter model. Fixed- and random-intercept variants of all models were tested using two cross-validation methods: leave-one-out at the level of valued health states, and of health state blocks used in EQ-5D-5L valuation studies. Mean absolute error, Lin concordance correlation coefficient, and Pearson R between observed health state means and out-of-sample predictions were compared. Predictive accuracy was generally best using random intercepts. The 8-, 9-, and 11-parameter models outperformed the 20-parameter model in predicting out-of-sample health states. Simplified nonlinear regression models look promising and should be investigated further using other EQ-5D-5L data sets. To reduce the risk of overfitting, cross-validation is recommended to inform model selection in future EQ-5D valuation studies. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  1. Coronary artery calcification in CKD-5D 
patients is tied to adverse cardiac function 
and increased mortality
.

    Science.gov (United States)

    Anaya, Paul; Blomquist, Gustav A; Davenport, Daniel L; Monier-Faugere, Marie-Claude; Sorrell, Vincent L; Malluche, Hartmut H

    2016-12-01

    Coronary artery calcification (CAC) is common in patients with chronic kidney disease on hemodialysis (CKD-5D) and is an important predictor of mortality. However, cardiac functional links between CAC and mortality have not been well established. This study tested the hypothesis that CAC increases mortality by adversely affecting cardiac function. Patients were recruited from 37 regional dialysis centers. 2-D and Doppler echocardiographic analyses were performed, and CAC was measured using 64-slice computed tomography. Relationships between CAC and echocardiographic measures of left ventricular (LV) function were analyzed. Survival was assessed with median follow-up of 37 months. There were 157 patients: 59% male, 46% Caucasian, 48% diabetic. Median age was 55 years, and median duration of CKD-5D was 45 months. Agatston CAC scores 100 were found in 69% of patients, with 51% having a score  400. CAC was associated with measures of LV systolic and diastolic function (global longitudinal strain (GLS; rho = 0.270, p = 0.004)), peak LV systolic velocity (rho = -0.259, p = 0.004), and estimate of LV filling pressure (E:E'; rho = 0.286, p = 0.001). Multivariate regression confirmed these relationships after adjustment for age, gender, LV ejection fraction, and coronary artery disease. Valvular calcification varied linearly with CAC (p diastolic and systolic functional measures were significant predictors of mortality, the strongest of which was LV diastolic dysfunction. These findings show a link between CAC, cardiac function, and mortality in CKD-5D. LV diastolic function (E:E'), peak LV systolic velocity, and GLS are independent predictors of mortality. Valvular calcification may be an important marker of CAC in CKD-5D. These effects on cardiac function likely explain the high mortality with CKD-5D and describe a potentially-valuable role for echocardiography in the routine management of these patients.
.

  2. Validity of EQ-5D in general population of Taiwan: results of the 2009 National Health Interview and Drug Abuse Survey of Taiwan.

    Science.gov (United States)

    Yu, Sheng-Tsung; Chang, Hsing-Yi; Yao, Kai-Ping; Lin, Yu-Hsuan; Hurng, Baai-Shyun

    2015-10-01

    The aim of this study was to examine the validity of the EuroQOL five dimensions questionnaire (EQ-5D) using a nationally representative data from the National Health Interview Survey (NHIS) through comparison with short-form 36 (SF-36). Data for this study came from the 2009 NHIS in Taiwan. The study sample was the 4007 participants aged 20-64 years who completed the survey. We used SUDAAN 10.0 (SAS-Callable) to carry out weighed estimation and statistical inference. The EQ index was estimated using norm values from a Taiwanese study as well as from Japan and the United Kingdom (UK). The SF-36 score was standardized using American norm values. In terms of concurrent validity, the EQ-5D met the five hypotheses. The results did not fulfill hypothesis that women would have lower visual analogue scale (EQ-VAS) scores. In terms of discriminant validity, the EQ-5D fulfilled two hypotheses. Our results approached but did not fulfill hypothesis that there would be a weak association between the physical and psychological dimensions of the EQ-5D and the mental component summary score of the SF-36. Results were comparable regardless of whether the Japanese or UK norm value sets were used. We were able to fulfill many, not all of our validity hypotheses regardless of whether the established Japanese or UK norm value sets or the Taiwanese norm values were used. The EQ-5D is an effective and simple instrument for assessing health-related quality of life of general population in Taiwan.

  3. Assessing quality of life in children and adolescents: development and validation of the Italian version of the EQ-5D-Y

    Directory of Open Access Journals (Sweden)

    Luciana Scalone

    2011-12-01

    Full Text Available

    Background: Although assessment of Health Related Quality of Life (HRQoL in paediatric populations is gaining interest, it is not sufficiently assessed. While a number of specific paediatric instruments have been developed, some users appear to prefer generic tools such as the EQ-5D, which is a widely used and recommended tool to describe and value health across many different adult populations. We adapted the EQ-5D generic instrument into the EQ-5D-Y(youth for the assessment of HRQoL in children and adolescents, and investigated the feasibility, acceptability, validity and reliability of this new version of the tool.

    Methods: The Italian version of the EQ-5D-Y was administered to 415 children and adolescents from a general population aged between 8 and 15, and to 25 paediatric patients diagnosed with Acute Lymphoblastic Leukaemia (ALL.

    Results: The Italian version of the EQ-5D-Y was found to be feasible and acceptable for self-completion in the target age-group, with less than 1% refusing to complete it and no invalid answers given. Convergent and divergent validity tested with a child specific standard instrument was satisfactory overall. The test-retest reliability was moderate to good in all the domains of the descriptive system, and the Visual Analogue Scale (VAS showed optimal levels of reliability (Intraclass Correlation Coefficient = 0.82. As regards known-group validity, compared with the youths from general population, the ALL patients reported more difficulties in four of the five domains of the descriptive system and, on average, had a lower VAS score.

    Conclusions:The Italian version of the EQ-5D-Y shows to be a promising tool for assessing HRQoL in children and adolescents from 8 to 15 years of age. Future studies should further investigate and optimize its applicability to clinical research and carry out economic evaluations within the health

  4. Profile of World Uranium Enrichment Programs-2009

    Energy Technology Data Exchange (ETDEWEB)

    Laughter, Mark D [ORNL

    2009-04-01

    It is generally agreed that the most difficult step in building a nuclear weapon is acquiring fissile material, either plutonium or highly enriched uranium (HEU). Plutonium is produced in a nuclear reactor, whereas HEU is produced using a uranium enrichment process. Enrichment is also an important step in the civil nuclear fuel cycle, in producing low enriched uranium (LEU) for use as fuel for nuclear reactors to generate electricity. However, the same equipment used to produce LEU for nuclear reactor fuel can also be used to produce HEU for weapons. Safeguards at an enrichment plant are the array of assurances and verification techniques that ensure uranium is not diverted or enriched to HEU. There are several techniques for enriching uranium. The two most prevalent are gaseous diffusion, which uses older technology and requires a lot of energy, and gas centrifuge separation, which uses more advanced technology and is more energy efficient. Gaseous diffusion plants (GDPs) provide about 40% of current world enrichment capacity but are being phased out as newer gas centrifuge enrichment plants (GCEPs) are constructed. Estimates of current and future enrichment capacity are always approximate, due to the constant upgrades, expansions, and shutdowns occurring at enrichment plants, largely determined by economic interests. Currently, the world enrichment capacity is approximately 56 million kilogram separative work units (SWU) per year, with 22.5 million in gaseous diffusion and more than 33 million in gas centrifuge plants. Another 34 million SWU/year of capacity is under construction or planned for the near future, almost entirely using gas centrifuge separation. Other less-efficient techniques have also been used in the past, including electromagnetic and aerodynamic separations, but these are considered obsolete, at least from a commercial perspective. Laser isotope separation shows promise as a possible enrichment technique of the future but has yet to be

  5. GLANET: genomic loci annotation and enrichment tool.

    Science.gov (United States)

    Otlu, Burçak; Firtina, Can; Keles, Sündüz; Tastan, Oznur

    2017-09-15

    Genomic studies identify genomic loci representing genetic variations, transcription factor (TF) occupancy, or histone modification through next generation sequencing (NGS) technologies. Interpreting these loci requires evaluating them with known genomic and epigenomic annotations. We present GLANET as a comprehensive annotation and enrichment analysis tool which implements a sampling-based enrichment test that accounts for GC content and/or mappability biases, jointly or separately. GLANET annotates and performs enrichment analysis on these loci with a rich library. We introduce and perform novel data-driven computational experiments for assessing the power and Type-I error of its enrichment procedure which show that GLANET has attained high statistical power and well-controlled Type-I error rate. As a key feature, users can easily extend its library with new gene sets and genomic intervals. Other key features include assessment of impact of single nucleotide variants (SNPs) on TF binding sites and regulation based pathway enrichment analysis. GLANET can be run using its GUI or on command line. GLANET's source code is available at https://github.com/burcakotlu/GLANET . Tutorials are provided at https://glanet.readthedocs.org . burcak@ceng.metu.edu.tr or oznur.tastan@cs.bilkent.edu.tr. Supplementary data are available at Bioinformatics online.

  6. Enrichment of Acinetobacter spp. from food samples.

    Science.gov (United States)

    Carvalheira, Ana; Ferreira, Vânia; Silva, Joana; Teixeira, Paula

    2016-05-01

    Relatively little is known about the role of foods in the chain of transmission of acinetobacters and the occurrence of different Acinetobacter spp. in foods. Currently, there is no standard procedure to recover acinetobacters from food in order to gain insight into the food-related ecology and epidemiology of acinetobacters. This study aimed to assess whether enrichment in Dijkshoorn enrichment medium followed by plating in CHROMagar™ Acinetobacter medium is a useful method for the isolation of Acinetobacter spp. from foods. Recovery of six Acinetobacter species from food spiked with these organisms was compared for two selective enrichment media (Baumann's enrichment and Dijkshoorn's enrichment). Significantly (p Acinetobacter was applied to detect Acinetobacter spp. in different foods. Fourteen different presumptive acinetobacters were recovered and assumed to represent nine different strains on the basis of REP-PCR typing. Eight of these strains were identified by rpoB gene analysis as belonging to the species Acinetobacter johnsonii, Acinetobacter calcoaceticus, Acinetobacter guillouiae and Acinetobacter gandensis. It was not possible to identify the species level of one strain which may suggests that it represents a distinct species. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Do positive affectivity and boundary preferences matter for work-family enrichment? A study of human service workers.

    Science.gov (United States)

    McNall, Laurel A; Scott, Lindsay D; Nicklin, Jessica M

    2015-01-01

    More individuals than ever are managing work and family roles, but relatively little research has been done exploring whether boundary preferences help individuals benefit from multiple role memberships. Drawing on Greenhaus and Powell's (2006) work-family enrichment theory, along with Boundary Theory (Ashforth, Kreiner, & Fugate, 2000) and Conservation of Resources Theory (Hobfoll, 2002), we explore the impact of personal characteristics as enablers of work-family enrichment, and in turn, work outcomes relevant to human service workers: turnover intentions and emotional exhaustion. In a 2-wave study of 161 human service employees, we found that individuals high in positive affectivity were more likely to experience both work-to-family and family to-work enrichment, whereas those with preferences toward integration were more likely to experience work-to-family enrichment (but not family to-work enrichment). In turn, work-to-family enrichment (but not family to-work enrichment) was related to lower turnover intentions and emotional exhaustion. Enrichment served as a mediating mechanism for only some of the hypothesized relationships. Implications for theory and practice are discussed. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  8. Emergence of non-Fermi liquid behaviors in 5d perovskite SrIrO3 thin films: Interplay between correlation, disorder, and spin-orbit coupling

    Science.gov (United States)

    Biswas, Abhijit; Kim, Ki-Seok; Jeong, Yoon H.

    2016-02-01

    We investigate the effects of compressive strain on the electrical resistivity of 5d iridium based perovskite SrIrO3 by depositing epitaxial films of thickness 35 nm on various substrates such as GdScO3 (110), DyScO3 (110), and SrTiO3 (001). Surprisingly, we find anomalous transport behaviors as expressed by ρ∝Tε in the temperature dependent resistivity, where the temperature exponent ε evolves continuously from 4/5 to 1 and to 3/2 with an increase of compressive strain. Furthermore, magnetoresistance always remains positive irrespective of resistivity upturns at low temperatures. These observations imply that the delicate interplay between correlation and disorder in the presence of strong spin-orbit coupling is responsible for the emergence of the non-Fermi liquid behaviors in 5d perovskite SrIrO3 thin films. We offer a theoretical framework for the interpretation of the experimental results.

  9. Scalar fluctuations of the scalar metric during inflation from a non-perturbative 5D large-scale repulsive gravity model

    Energy Technology Data Exchange (ETDEWEB)

    Madriz Aguilar, Jose Edgar; Reyes, Luz M.; Moreno, Claudia [Universidad de Guadalajara (UdG), Departamento de Matematicas, Centro Universitario de Ciencias Exactas e ingenierias (CUCEI), Guadalajara, Jalisco (Mexico); Bellini, Mauricio [Universidad Nacional de Mar del Plata (UNMdP), Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Funes 3350, C.P. 7600, Mar del Plata (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Instituto de Investigaciones Fisicas de Mar del Plata (IFIMAR), Mar del Plata (Argentina)

    2013-10-15

    We develop a non-perturbative formalism for scalar metric fluctuations from a 5D extended version of general relativity in vacuum. In this work we concentrate our efforts on calculations valid on large cosmological scales, which are dominant during the inflationary phase of the universe. The resulting metric in this limit is obtained after implementing a planar coordinate transformation on a 5D Ricci-flat metric solution. We calculate the spectrum of these fluctuations with an effective 4D Schwarzschild-de Sitter spacetime on cosmological scales, which is obtained after we make a static foliation on the non-compact extra coordinate. Our results show how the squared metric fluctuations of the primordial universe become scale invariant with the inflationary expansion. (orig.)

  10. Valuation of EQ-5D-3L health states in Singapore: modeling of time trade-off values for 80 empirically observed health states.

    Science.gov (United States)

    Luo, Nan; Wang, Pei; Thumboo, Julian; Lim, Yee-Wei; Vrijhoef, Hubertus J M

    2014-05-01

    The aim of this study was to establish an EQ-5D-3L value set using the time trade-off (TTO) method to elicit the health preferences of the general Singaporean population. The values of 80 EQ-5D-3L health states were elicited from a general Singaporean population sample using a TTO method. In face-to-face interviews, participants were asked to value a block of ten health states. Various linear regression models were examined to assess for goodness of fit to the data, at both aggregate and individual levels. Prediction precision was assessed in terms of mean absolute error (MAE), and numbers of prediction errors larger than 0.10 and 0.20. Prediction consistency and bias were also assessed. A total of 456 participants provided data for this study. The N3 model without a constant estimated using the aggregate data exhibited the best fit of the data, predicted values with the least bias, and generated logically consistent values for all 243 EQ-5D-3L health states. The MAE was 0.1137, and 35 of 80 predicted values had errors less than 0.10 in absolute magnitude. Based on this model, the utility values ranged from 0.854 for state 11121 to -0.769 for state 33333. The EQ-5D-3L value set can be estimated using the TTO method in the multi-cultural, multi-ethnic Singapore. Although the estimation precision is not optimal, the health-state preference values generated in this study are useful to health service researchers in the country before estimates with smaller errors are available.

  11. Vacuum Referred Binding Energy of the Single 3d, 4d, or 5d Electron in Transition Metal and Lanthanide Impurities in Compounds

    NARCIS (Netherlands)

    Rogers, E.G.; Dorenbos, P.

    2014-01-01

    The vacuum referred binding energy (VRBE) of the single electron in the lowest energy 3d level of Sc2 +, V4 +, Cr5 +, the lowest 4d level of Y2 +, Zr3 +, Nb4 +, Mo5 + and the lowest 5d level of Ta4 +, and W5 + in various compounds are determined by means of the chemical shift model. They will be

  12. Impact evaluation and association with EuroQol 5D health-related utility values in Ménière's disease.

    Science.gov (United States)

    Pyykkő, Ilmari; Manchaiah, Vinaya; Levo, Hilla; Kentala, Erna

    2015-01-01

    The study was aimed at evaluating the validity of impact measures among patients with Ménière's disease (MD) with outcome variables of EuroQol generic health-related quality of life (HRQoL) measures (i.e., EQ-5D) by using Visual Analogue Scale (VAS) and EQ-5D index values. 183 members (out of 200 contacted) of the Finish Ménière Association returned the questionnaires that they had filled out. Various open-ended and structured questionnaires focusing on diagnostic aspects of symptoms and impairment caused by the disease were used. For activity limitation and participation restriction, standardized questionnaires were used. Open-ended questions on impact of the disease were asked, and subsequently classified based on the WHO-ICF classification. The general HRQoL was evaluated with EQ-5D index value and EQ VAS instruments. Correlation and linear regression analyses were used to explore the association between HRQoL and other aspects. Based on the explanatory power of different models the disease specific semeionic model provides the most accurate prediction in EQ-5D index calculations (38 % of the variance explained). In EQ VAS scores, HRQoL is most accurately determined by participation restriction (53 % of the variance explained), but the worst prediction was in ICF-based limitations (8 % of the variance explained). Interestingly, attitude and personal trait explained the reduction of HRQoL somewhat better than ICF-based variables. Activity limitation and participation restrictions are significant components of MD, but are less frequently recognized as significant factors in self-evaluating the effect of MD on the quality of life. The current study results suggest that MD patients seem to have problem identifying factors causing activity limitation and participation restrictions and hence use the semiotic description focusing on complaints.

  13. The level of physical exercise is associated with self-reported health status (EQ-5D) in adults with congenital heart disease.

    Science.gov (United States)

    Sandberg, Camilla; Engström, Karl Gunnar; Dellborg, Mikael; Thilén, Ulf; Wadell, Karin; Johansson, Bengt

    2015-02-01

    The prognosis in adults with congenital aortic valve disease is usually favourable; nevertheless, a number of medical and social factors might hamper long-term prognosis and quality of life. With a focus on physical exercise level, data from the Swedish National Registry on Congenital Heart Disease (SWEDCON) were analysed and variables associated with health-related quality of life in adults with congenital aortic valve disease were identified. In this registry study, SWEDCON was searched for adult patients with isolated congenital aortic valve disease and valid EuroQol-5Dimensions health questionnaire (EQ-5D) data. This study identified 315 patients. The majority (n = 202, 64%) reported best possible health status (EQ-5D(index) = 1) whereas 113 (35%) reported some impairment (EQ-5D(index)  3 h/week was independently associated with best possible health status (EQ-5D(index) = 1; p = 0.013). Moreover presence of cardiovascular symptoms (p 3 h/week was, as a single variable, associated with best possible health status in adults with congenital aortic valve disease. In contrast, a number of medical and social factors are associated with worse self-reported health status. Among these, symptoms, smoking, and educational level are potential targets for modification and intervention. There is a need for studies investigating the effect of increased level of physical exercise in patients with congenital aortic valve disease. © The European Society of Cardiology 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  14. Modeling elastic and thermal properties of 2.5D carbon fiber and carbon/SiC hybrid matrix composites by homogenization method

    OpenAIRE

    Luiz Claudio Pardini; Maria Luisa Gregori

    2010-01-01

    Abstract: Advanced carbon fiber hybrid carbon-ceramic matrix composites are realizing their potential in many thermostructural components for aerospace vehicles. This work presents ab-initio predictions of elastic constants and thermal properties for 2.5D carbon fiber reinforced carbon-silicon carbide hybrid matrix composites, by using the homogenization technique. The homogenization technique takes properties of individual components of the composites (fiber and matrix) and characteristics o...

  15. Modeling elastic and thermal properties of 2.5D carbon fiber and carbon/SiC hybrid matrix composites by homogenization method

    Directory of Open Access Journals (Sweden)

    Luiz Claudio Pardini

    2010-08-01

    Full Text Available Advanced carbon fiber hybrid carbon-ceramic matrix composites are realizing their potential in many thermostructural components for aerospace vehicles. This work presents ab-initio predictions of elastic constants and thermal properties for 2.5D carbon fiber reinforced carbon-silicon carbide hybrid matrix composites, by using the homogenization technique. The homogenization technique takes properties of individual components of the composites (fiber and matrix and characteristics of the geometrical architecture of the preform to perform calculations. Ab-initio modeling of mechanical and thermal properties is very attractive, especially during the material development stage, when larger samples may be prohibitively expensive or impossible to fabricate. Modeling is also useful when bigger samples would be prohibitively expensive or impractical. Thermostructural composites made of 2.5D preforms are easy to manufacture in relation to 3D preforms. Besides, 2.5D preforms are also resistant to thermo cycling and have high resistance to crack propagation in relation to ply stacked composites such as unidirectional (1D and bidirectional (2D structures. The calculations were performed by setting an overall carbon fiber volume fraction at 40, 45 and 50 for a 2D stacked composite, and volume fraction in Z-direction of 2, 4 and 6.

  16. Investigating the Possibility to Reduce the Residual Stress Level in 2.5D Cutting Using Titanium Coated Carbide Ball End Mill

    Directory of Open Access Journals (Sweden)

    N. Masmiati

    2014-01-01

    Full Text Available End milling is a multipoint cutting process in which material is removed from a workpiece by a rotating tool. It is widely used in cutting 2.5D profiles such as point-to-point, contouring, and pocketing operations. 2.5D machining possesses the capability to translate in all 3 axes but can perform the cutting operation in only 2 of the 3 axes at a time. This study focuses on optimizing the cutting parameters, such as machined surface inclinationangle, axial depth of cut, spindle speed, and feed rate for better surface integrity, namely, microhardness, residual stress, and microstructure in 2.5D cutting utilizing a titanium-coated carbide ball end mill. An optimization method known as Taguchi optimization, which includes planning, conducting, and analyzing results of matrix experiments, was used in order to achieve the best cutting parameter level. Data analysis was conducted using signal-to-noise (S/N and target performance measurement (TPM response analysis and analysis of variance (Pareto ANOVA. The optimum condition results obtained through analysis show improvements in microhardness of about 0.7%, residual stress in the feed direction of about 18.6%, and residual stress in the cutting direction of about 15.4%.

  17. A time course analysis of enriched composition.

    Science.gov (United States)

    McElree, Brian; Pylkkänen, Liina; Pickering, Martin J; Traxler, Matthew J

    2006-02-01

    Linguistic analyses suggest that common and seemingly simple expressions, such as began the book, cannot be interpreted with simple compositional processes; rather, they require enriched composition to provide an interpretation, such as began reading the book (Jackendoff, 1997; Pustejovsky, 1995). Recent reading time studies have supported these accounts by providing evidence that these expressions are more costly to process than are minimally contrasting controls (e.g., McElree, Traxler, Pickering, Seely, and Jackendoff, 2001). We report a response signal speed-accuracy trade-off (SAT) study in which two types of expressions that are thought to require enriched composition were examined. Analyses of the full time course SAT data indicate that these expressions were interpreted less accurately and, most importantly, more slowly than control sentences. The latter finding suggests that enriched composition requires the online deployment of complex compositional operations.

  18. Nutrient enrichment increases mortality of mangroves.

    Directory of Open Access Journals (Sweden)

    Catherine E Lovelock

    Full Text Available Nutrient enrichment of the coastal zone places intense pressure on marine communities. Previous studies have shown that growth of intertidal mangrove forests is accelerated with enhanced nutrient availability. However, nutrient enrichment favours growth of shoots relative to roots, thus enhancing growth rates but increasing vulnerability to environmental stresses that adversely affect plant water relations. Two such stresses are high salinity and low humidity, both of which require greater investment in roots to meet the demands for water by the shoots. Here we present data from a global network of sites that documents enhanced mortality of mangroves with experimental nutrient enrichment at sites where high sediment salinity was coincident with low rainfall and low humidity. Thus the benefits of increased mangrove growth in response to coastal eutrophication is offset by the costs of decreased resilience due to mortality during drought, with mortality increasing with soil water salinity along climatic gradients.

  19. 136Xe enrichment through cryogenic distillation

    Science.gov (United States)

    Back, H. O.; Bottenus, D. R.; Clayton, C.; Stephenson, D.; TeGrotenhuis, W.

    2017-09-01

    The next generation of 136Xe neutrinoless double beta decay experiments will require on the order of 5 tons of enriched 136Xe. By estimating the relative volatilities of the xenon isotopes and using standard chemical engineering techniques we explore the feasibility of using cryogenic distillation to produce 5 tons of 80% enriched 136Xe in 5-6 years. With current state-of-the-art distillation column packing materials we can estimate the total height of a traditional cryogenic distillation column. We also report on how Micro Channel Distillation may reduce the overall size of a distillation system for 136Xe production.

  20. Microsatellite markers isolated from the wild medicinal plant Centella asiatica (Apiaceae) from an enriched genomic library.

    Science.gov (United States)

    Rakotondralambo, Soaharin'ny Ony Raoseta; Lussert, Alexandra; Rivallan, Ronan; Danthu, Pascal; Noyer, Jean-Louis; Baurens, Franc-Christophe

    2012-04-01

    Microsatellite markers for Centella asiatica, an important medicinal herb, were developed and characterized to promote genetic and molecular studies. A GA/GT-enriched genomic library was constructed from an accession from Madagascar. Roughly 75% of the 768 clones of the enriched library contained microsatellites. Eighty sequences containing microsatellites were obtained from 96 positive clones. Specific primers were designed for 20 loci, and 17 of them displayed polymorphism when screened across 17 C. asiatica accessions, with an average of 4.3 alleles per locus. The observed and expected heterozygosity values averaged 0.114 and 0.379, respectively. This is the first report constructing an enriched genomic library and identifying microsatellite markers from C. asiatica. These 17 polymorphic microsatellite markers are a useful resource for this plant, applicable for diversity studies, pedigree analyses, and genetic mapping.

  1. Enriching semantic knowledge bases for opinion mining in big data applications.

    Science.gov (United States)

    Weichselbraun, A; Gindl, S; Scharl, A

    2014-10-01

    This paper presents a novel method for contextualizing and enriching large semantic knowledge bases for opinion mining with a focus on Web intelligence platforms and other high-throughput big data applications. The method is not only applicable to traditional sentiment lexicons, but also to more comprehensive, multi-dimensional affective resources such as SenticNet. It comprises the following steps: (i) identify ambiguous sentiment terms, (ii) provide context information extracted from a domain-specific training corpus, and (iii) ground this contextual information to structured background knowledge sources such as ConceptNet and WordNet. A quantitative evaluation shows a significant improvement when using an enriched version of SenticNet for polarity classification. Crowdsourced gold standard data in conjunction with a qualitative evaluation sheds light on the strengths and weaknesses of the concept grounding, and on the quality of the enrichment process.

  2. INFLUENCIA DE LOS PROBLEMAS CRÓNICOS DE SALUD EN LAS DIMENSIONES DEL CUESTIONARIO EQ-5D: ESTUDIO EN PERSONAS MAYORES INSTITUCIONALIZADAS Y NO INSTITUCIONALIZADAS

    Directory of Open Access Journals (Sweden)

    María Concepción Delgado-Sanz

    2011-01-01

    Full Text Available Fundamento: Las enfermedades crónicas representan factores de riesgo para la calidad de vida relacionada con la salud (CVRS. El objetivo de estudio es analizar la influencia de problemas crónicos de salud autodeclarados en la CVRS, medida a través de las dimensiones del EQ-5D, en personas mayores institucionalizada y no institucionalizada. Métodos: Los datos proceden de dos estudios sobre calidad de vida en personas con 60 o más años de edad, en España, con una muestra de 1.106 personas mayores viviendo en la comunidad, y 234 en centros residenciales. Para analizar la influencia de los problemas crónicos más prevalentes en la CVRS se ajustaron modelos de regresión logística tomando como variable dependiente cada dimensión del EQ-5D y controlando por variables sociodemográficas. Resultados: Los problemas crónicos de salud que influyeron negativamente en la CVRS de los dos grupos de población estudiados, fueron la depresión (rango de OR en las distintas dimensiones del EQ-5D:1,97-6,48, seguida de artrosis/artritis (OR:2,81-6,00, insomnio (OR:2,81-4,61, diabetes (OR:1,68-3,44 e hipertensión arterial (OR:1,42-2,45. Estos problemas afectaron de forma distinta a las dimensiones del EQ-5D y a los dos grupos considerados. Las dimensiones del EQ-5D en las que se observaron más dificultades fueron dolor/malestar y movilidad. Conclusiones: Los resultados de este trabajo indican que el carácter debilitante de las enfermedades crónicas sobre la CVRS es distinto en personas mayores institucionalizadas y no institucionalizadas. Además, destacan la importancia de la promoción de un envejecimiento saludable para atenuar el impacto negativo de los problemas crónicos de la salud sobre la población mayor.

  3. Assessing the Health-Related Quality of Life of Australian Adolescents: An Empirical Comparison of the Child Health Utility 9D and EQ-5D-Y Instruments.

    Science.gov (United States)

    Chen, Gang; Flynn, Terry; Stevens, Katherine; Brazier, John; Huynh, Elisabeth; Sawyer, Michael; Roberts, Rachel; Ratcliffe, Julie

    2015-06-01

    To examine the performance of two recently developed preference-based instruments-the Child Health Utility 9D (CHU9D) and the EuroQol five-dimensional questionnaire Youth version (EQ-5D-Y)-in assessing the health-related quality of life (HRQOL) of Australian adolescents. An online survey including the CHU9D and the EQ-5D-Y, self-reported health status, and a series of sociodemographic questions was developed for administration to a community-based sample of adolescents (aged 11-17 years). Individual responses to both instruments were translated into utilities using scoring algorithms derived from the Australian adult general population. A total of 2020 adolescents completed the online survey. The mean ± SD utilities of the CHU9D and the EQ-5D-Y were very similar (0.82 ± 0.13 and 0.83 ± 0.19, respectively), and the intraclass correlation coefficient (0.80) suggested good levels of agreement. Both instruments were able to discriminate according to varying levels of self-reported health status (P < 0.001). Although exhibiting good levels of agreement overall, some wide divergences were apparent at an individual level. The study results are encouraging and illustrate the potential for both the CHU9D and the EQ-5D-Y to be more widely used for measuring and valuing the HRQOL of adolescent populations in Australia and internationally. Generating adolescent-specific scoring algorithms pertaining to each instrument and an empirical comparison of the resulting utilities is a natural next step. More evidence is required from the application of the CHU9D and the EQ-5D-Y in specific patient groups in adolescent health settings to inform the choice of instrument for measuring and valuing the HRQOL for the economic evaluation of adolescent health care treatments and services. Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  4. Comparing the self-perceived quality of life of multimorbid patients and the general population using the EQ-5D-3L.

    Directory of Open Access Journals (Sweden)

    Alexandra A N'Goran

    Full Text Available To assess and compare the self-perceived Health Related Quality of Life (HRQoL of multimorbid patients and the general population using health utilities (HU and visual analogue scale (VAS methods.We analyzed data (n = 888 from a national, cross-sectional Swiss study of multimorbid patients recruited in primary care settings. Self-perceived HRQoL was assessed using the EQ-5D-3L instrument, composed of 1 a questionnaire on the five dimensions of mobility, self-care, usual activities, pain/discomfort, and anxiety/depression (EQ-5D dimensions, and 2 a 0-100 (0 = worst- and 100 = best-imaginable health status VAS. We described the EQ-5D dimensions and VAS and computed HU using a standard pan-European value set. HU and VAS are the two components of the overall HRQoL assessment. We examined the proportions of multimorbid patients reporting problems (moderate/severe in each EQ-5D dimension, corresponding proportions without problems, and mean HU and VAS values across patient characteristics. To test differences between subgroups, we used chi-square tests for dichotomous outcomes and T-tests (ANOVA if more than two groups for continuous outcomes. Finally, we compared observed and predicted HU and VAS values.All 888 participants answered every EQ-5D item. Mean (SD HU and VAS values were 0.70 (0.18 and 63.2 (19.2, respectively. HU and VAS were considerably and significantly lower in multimorbid patients than in the general population and were also lower in multimorbid patients below 60 years old and in women. Differences between observed and predicted means (SD were -0.07 (0.18 for HU and -11.8 (20.3 for VAS.Self-perceived HRQoL is considerably and significantly affected by multimorbidity. More attention should be given to developing interventions that improve the HRQoL of multimorbid patients, particularly women and those aged below 60 years old.

  5. 76 FR 34103 - In the Matter of Areva Enrichment Services, LLC (Eagle Rock Enrichment Facility); Notice of...

    Science.gov (United States)

    2011-06-10

    ... COMMISSION Atomic Safety and Licensing Board In the Matter of Areva Enrichment Services, LLC (Eagle Rock... hearing'' portion of this proceeding regarding the December 2008 application by AREVA Enrichment Services... Information for Contention Preparation; In the Matter of Areva Enrichment Services, LLC (Eagle Rock Enrichment...

  6. EQ-5D utility, response and drug survival in rheumatoid arthritis patients on biologic monotherapy: A prospective observational study of patients registered in the south Swedish SSATG registry.

    Directory of Open Access Journals (Sweden)

    Tanja Schjødt Jørgensen

    Full Text Available Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA. To date only scarce head-to-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs. Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (EQ-5D-3L and drug survival of biologic DMARDs (bDMARDs prescribed as monotherapy in RA patients in southern Sweden.All RA patients registered in a regional database as initiating bDMARD as monotherapy, i.e. without concomitant conventional synthetic DMARDs (csDMARDs, from 1st of January 2006 through 31st of December 2012, were included. Patients were followed from initiation of the first dose of bDMARD monotherapy treatment until withdrawal from treatment, loss of follow-up or 31st of December 2012. Descriptive statistics for utility (EQ-5D-3L, effectiveness, and drug survival of bDMARD monotherapy were calculated.During the study period, a total of 554 patients were registered in SSATG as initiating bDMARD monotherapy. Most of the patients were women (81%, with a mean age of 57 years. The average disease duration was more than 12 years, and on average the patients had previously been treated with approximately four different csDMARDs. Fifty-five percent of the patients were initiating their first bDMARD, 26% their second, and 19% their third or more. At baseline the average EQ-5D-3L was 0.34. Most patients had moderate to high disease activity, with a mean DAS28 of 5.0, and were substantially disabled, with an average HAQ score of 1.4. At 6 months´ follow-up, the EQ-5D-3L in patients still on the biologic drug had increased by mean 0.23 (SD 0.4 with no differences between type of bDMARD (p = 0.49. The mean change in EQ-5D-3L ranged from 0.11 (rituximab and infliximab to 0.42 (tocilizumab. Although the changes were numerically different, no distinct pattern favored

  7. Algae Resources

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    Algae are highly efficient at producing biomass, and they can be found all over the planet. Many use sunlight and nutrients to create biomass, which contain key components—including lipids, proteins, and carbohydrates— that can be converted and upgraded to a variety of biofuels and products. A functional algal biofuels production system requires resources such as suitable land and climate, sustainable management of water resources, a supplemental carbon dioxide (CO2) supply, and other nutrients (e.g., nitrogen and phosphorus). Algae can be an attractive feedstock for many locations in the United States because their diversity allows for highpotential biomass yields in a variety of climates and environments. Depending on the strain, algae can grow by using fresh, saline, or brackish water from surface water sources, groundwater, or seawater. Additionally, they can grow in water from second-use sources such as treated industrial wastewater; municipal, agricultural, or aquaculture wastewater; or produced water generated from oil and gas drilling operations.

  8. Chances and challenges of forest scale CO2 enrichment

    Science.gov (United States)

    Körner, Christian

    2016-04-01

    , given the sheer size such test systems would require. I rather suggest combining the best choice technology at different scales, which is not necessarily the most costly FACE approach. FACE emerged from overestimating potential bias from atmospheric conditions and greatly unerestimating the key role of soil conditions and biodiversity. Reference: Körner C (2006) Plant CO2 responses: an issue of definition, time and resource supply. New Phytol 172:393-411. Bader MKF, et al. (2013) Central European hardwood trees in a high-CO2 future: synthesis of an 8-year forest canopy CO2 enrichment project. J Ecol 101:1509-1519.

  9. Resource Management

    Science.gov (United States)

    1993-01-01

    Summit Envirosolutions of Minneapolis, Minnesota, used remote sensing images as a source for groundwater resource management. Summit is a full-service environmental consulting service specializing in hydrogeologic, environmental management, engineering and remediation services. CRSP collected, processed and analyzed multispectral/thermal imagery and aerial photography to compare remote sensing and Geographic Information System approaches to more traditional methods of environmental impact assessments and monitoring.

  10. Enriching and Assessing Young Children's Multimodal Storytelling

    Science.gov (United States)

    Wessel-Powell, Christy; Kargin, Tolga; Wohlwend, Karen E.

    2016-01-01

    This article provides primary teachers with assessment tools and curricular examples to expand writers' workshop by adding a multimodal storytelling unit on drama and filmmaking, allowing students to create engaging off-the-page stories through films and play performances that enrich writing. Too often, children's literacy abilities are assessed…

  11. The Partnership on Work Enrichment and Readiness

    Science.gov (United States)

    Haar, Diane; Raggi, Mindi

    2009-01-01

    The Partnership on Work Enrichment and Readiness (POWER's) unique and innovative curriculum recruits and sustains nontraditional students interested in preparing for employment or continued studies in an institution of higher education. The program specifically targets persons in mental health recovery. Students attend college during a regular…

  12. Curriculum enrichment through indigenous Zulu games | Roux ...

    African Journals Online (AJOL)

    The aim of the study was to document and analyze indigenous Zulu games for possible curriculum enrichment of physical education in schools and the promotion of cross-cultural interaction between learners. This necessitated the identification and description of indigenous Zulu games in order to assess their potential in

  13. Enriched vibrational resonance in certain discrete systems

    Indian Academy of Sciences (India)

    We wish to report the occurrence of vibrational resonance in certain discrete systems like sine square map and sine circle map, in a unique fashion, comprising of multiple resonant peaks which pave the way for enrichment. As the systems of our choice are capable of exhibiting vibrational resonance behaviour unlike the ...

  14. Omgevingsverrijking voor vleeskalkoenen = Environmental enrichment for turkeys

    NARCIS (Netherlands)

    Veldkamp, T.

    2012-01-01

    A desk study has been conducted to study the possible environmental enrichments in order to reduce injurious pecking behaviour in intact turkeys. Free hanging materials are attractive to turkeys and are technically and economically feasible. Perches and elevated platforms are less feasible.

  15. Recommendations based on semantically enriched museum collections

    NARCIS (Netherlands)

    Y. Wang (Yanjing); N. Stash; L. Aroyo; P. Gorgels; L. Rutledge (Lloyd); G. Schreiber

    2008-01-01

    htmlabstractThis article presents the CHIP demonstrator1 for providing personalized access to digital museum collections. It consists of three main components: Art Recommender, Tour Wizard, and Mobile Tour Guide. Based on the semantically enriched Rijksmuseum Amsterdam2 collection, we show how

  16. Functional properties of soy-enriched tapioca

    African Journals Online (AJOL)

    my mord

    1Department of Food Science and Technology, Bowen University, Iwo, Osun State, Nigeria. 2Department of Human ... security. Key words: Functional properties, tapioca, cassava, starch grit, soy flour, soy-enriched tapioca, viscosity, soy- substitution. ... as the main raw material used in tapioca production is a rich source of ...

  17. The enrichment history of cosmic metals

    Science.gov (United States)

    Wiersma, Robert P. C.; Schaye, Joop; Dalla Vecchia, Claudio; Booth, C. M.; Theuns, Tom; Aguirre, Anthony

    2010-11-01

    We use a suite of cosmological, hydrodynamical simulations to investigate the chemical enrichment history of the Universe. Specifically, we trace the origin of the metals back in time to investigate when various gas phases were enriched and by what halo masses. We find that the age of the metals decreases strongly with the density of the gas in which they end up. At least half of the metals that reside in the diffuse intergalactic medium (IGM) at z = 0 (z = 2) were ejected from galaxies above z = 2 (z = 3). The mass of the haloes that last contained the metals increases rapidly with the gas density. More than half of the mass in intergalactic metals was ejected by haloes with total masses less than 1011 Msolar and stellar masses less than 109 Msolar. The range of halo masses that contribute to the enrichment is wider for the hotter part of the IGM. By combining the `when' and `by what' aspects of the enrichment history, we show that metals residing in the lower density gas were typically ejected earlier and by lower mass haloes.

  18. Phosphopeptide enrichment by immobilized metal affinity chromatography

    DEFF Research Database (Denmark)

    Thingholm, Tine E.; Larsen, Martin R.

    2016-01-01

    Immobilized metal affinity chromatography (IMAC) has been the method of choice for phosphopeptide enrichment prior to mass spectrometric analysis for many years and it is still used extensively in many laboratories. Using the affinity of negatively charged phosphate groups towards positively...

  19. Enriching a Descriptive Grammar with Treebank Queries

    NARCIS (Netherlands)

    Bouma, G.; van Koppen, J.M.; Landsbergen, Frank; Odijk, J.E.J.M.; van der Wouden, Ton; van de Camp, Matje

    2015-01-01

    The Syntax of Dutch (SoD) is a descriptive and detailed grammar of Dutch, that provides data for many issues raised in linguistic theory. We present the results of a pilot project that investigated the possibility of enriching the online version of the text with links to queries that provide

  20. Prediction of cadmium enrichment in reclaimed coastal soils by classification and regression tree

    Science.gov (United States)

    Ru, Feng; Yin, Aijing; Jin, Jiaxin; Zhang, Xiuying; Yang, Xiaohui; Zhang, Ming; Gao, Chao

    2016-08-01

    Reclamation of coastal land is one of the most common ways to obtain land resources in China. However, it has long been acknowledged that the artificial interference with coastal land has disadvantageous effects, such as heavy metal contamination. This study aimed to develop a prediction model for cadmium enrichment levels and assess the importance of affecting factors in typical reclaimed land in Eastern China (DFCL: Dafeng Coastal Land). Two hundred and twenty seven surficial soil/sediment samples were collected and analyzed to identify the enrichment levels of cadmium and the possible affecting factors in soils and sediments. The classification and regression tree (CART) model was applied in this study to predict cadmium enrichment levels. The prediction results showed that cadmium enrichment levels assessed by the CART model had an accuracy of 78.0%. The CART model could extract more information on factors affecting the environmental behavior of cadmium than correlation analysis. The integration of correlation analysis and the CART model showed that fertilizer application and organic carbon accumulation were the most important factors affecting soil/sediment cadmium enrichment levels, followed by particle size effects (Al2O3, TFe2O3 and SiO2), contents of Cl and S, surrounding construction areas and reclamation history.

  1. The Exchange Relationship between Work-Family Enrichment and Affective Commitment: the Moderating Role of Gender.

    Science.gov (United States)

    Marques, António Manuel; Chambel, Maria José; Pinto, Inês

    2015-06-03

    Workers' perception that their job experience enriches their family life has been considered a mechanism that explains their positive attitudes toward the organization where they work. However, because women and men live their work and family differently, gender may condition this relationship between the work-family enrichment and workers' attitudes. With a sample of 1885 workers from one Portuguese bank, with 802 women, the current study investigated the relationship between work-family enrichment and organizational affective commitment as well as the role of sex as a moderator of this relationship. The hypotheses were tested by using regression analysis. The results indicated that the perception held by workers that their work enriches their family is positively correlated with their affective commitment toward the organization. Furthermore, the data revealed that this relationship is stronger for women than for men. Study results have implications for management, particularly for human resource management, enhancing their knowledge about the relationship of work-family enrichment and workers' affective commitment toward organization.

  2. Fiction as a resource in participatory design

    DEFF Research Database (Denmark)

    Knutz, Eva; Ulv Lenskjold, Tau; Markussen, Thomas

    2016-01-01

    in collaborative design processes. We define the concept of resourcing on the basis of pragmatist process theories and complexity theory perspectives of social life, which enable us to explicate the gap between managerial thinking that understands resources as objective entities to be planned and controlled......, and the actual unfolding of co-design in complex responsive conversation. Through the analysis of three co-design events we illustrate how the different response sensitivities of co-designers can diversify and enrich resourcing. The analyses also reveal that resourcing is a dynamically evolving process......This paper introduces the concept of ‘resourcing’ to describe the fundamental activity of negotiating the use of what is available for co-design. Even though resourcing is an ever-present undertaking in all co-designing, no theoretical concept has thus far addressed the constitutive practices...

  3. On Heavy Element Enrichment in Classical Novae

    Science.gov (United States)

    Alexakis, A.; Calder, A. C.; Heger, A.; Brown, E. F.; Dursi, L. J.; Truran, J. W.; Rosner, R.; Lamb, D. Q.; Timmes, F. X.; Fryxell, B.; Zingale, M.; Ricker, P. M.; Olson, K.

    2004-02-01

    Many classical nova ejecta are enriched in CNO and Ne. Rosner and coworkers recently suggested that the enrichment might originate in the resonant interaction between large-scale shear flows in the accreted H/He envelope and gravity waves at the interface between the envelope and the underlying C/O white dwarf (WD). The shear flow amplifies the waves, which eventually form cusps and break. This wave breaking injects a spray of C/O into the superincumbent H/He. Using two-dimensional simulations, we formulate a quantitative expression for the amount of C/O per unit area that can be entrained, at saturation, into the H/He. The fraction of the envelope that is enriched depends on the horizontal distribution of shear velocity and the density contrast between the C/O WD and the H/He layer but is roughly independent of the vertical shape of the shear profile. Using this parameterization for the mixed mass, we then perform several one-dimensional Lagrangian calculations of an accreting WD envelope and consider two scenarios: that the wave breaking and mixing is driven by the convective flows and that the mixing occurs prior to the onset of convection. In the absence of enrichment prior to ignition, the base of the convective zone, as calculated from mixing-length theory with the Ledoux instability criterion, does not reach the C/O interface. As a result, there is no additional mixing, and the runaway is slow. In contrast, the formation of a mixed layer during the accretion of H/He, prior to ignition, causes a more violent runaway. The envelope can be enriched by <~25% of C/O by mass (consistent with that observed in some ejecta) for shear velocities, over the surface, with Mach numbers <~0.4.

  4. Energy resources

    CERN Document Server

    Simon, Andrew L

    1975-01-01

    Energy Resources mainly focuses on energy, including its definition, historical perspective, sources, utilization, and conservation. This text first explains what energy is and what its uses are. This book then explains coal, oil, and natural gas, which are some of the common energy sources used by various industries. Other energy sources such as wind, solar, geothermal, water, and nuclear energy sources are also tackled. This text also looks into fusion energy and techniques of energy conversion. This book concludes by explaining the energy allocation and utilization crisis. This publ

  5. Estimation and comparison of EQ-5D health states' utility weights for pneumococcal and human papillomavirus diseases in Argentina, Chile, and the United Kingdom.

    Science.gov (United States)

    Galante, Julieta; Augustovski, Federico; Colantonio, Lisandro; Bardach, Ariel; Caporale, Joaquin; Marti, Sebastian Garcia; Kind, Paul

    2011-01-01

    To estimate and compare EuroQol instrument (EQ-5D) health states' values for pneumococcal and human papillomavirus (HPV) diseases in Argentina, Chile, and the United Kingdom. Twelve vignettes were designed, pilot-tested, and administered to a convenience sample in a cross-sectional design to elicit descriptive EQ-5D state data. Country-specific EQ-5D time-trade-off-based weights were used to map these descriptive health states into local country preference weights. Descriptive analysis is reported and intercountry differences for each condition were compared using repeated measures analysis of variance. Seventy-three subjects completed the survey. Pneumococcal disease-related health states mean values ranged from -0.331 (sepsis, Chile) to 0.727 (auditive sequelae, Argentina). HPV-related conditions ranged from 0.152 (cervical cancer, United Kingdom) to 0.848 (cervical intraepithelial neoplasia 1, Argentina). Chile had consistently the lowest mean values in pneumococcal states and in one HPV state, whereas those of the United Kingdom were the lowest in most HPV states. Argentina had the highest mean values in both diseases. Differences in country-specific values for each health state were statistically (P < 0.001) significant except for six health states in which differences between Chilean and United Kingdom weights were nonsignificant. Utility values for most conditions differed statistically relevantly among analyzed countries, even though the same health states' descriptive set was valued for each. These results reflect the difference in social weights among different countries, which could be attributed to either different population values or valuation study methodologies. They stress the importance of using local preference weights for context-specific decision making. Copyright © 2011 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  6. Are the EQ-5D-3L and the ICECAP-O responsive among older adults with impaired mobility? Evidence from the Vancouver Falls Prevention Cohort Study.

    Science.gov (United States)

    Davis, Jennifer C; Best, John R; Dian, Larry; Khan, Karim M; Hsu, Chun Liang; Chan, Wency; Cheung, Winnie; Liu-Ambrose, Teresa

    2017-03-01

    Preference-based generic measures are gaining increased use in mobility research to assess health-related quality of life and wellbeing. Hence, we examined the responsiveness of these two measures among individuals at risk of mobility impairment among adults aged ≥70 years. We conducted a 12-month prospective cohort study of community-dwelling older adults (n = 288 to n = 341 depending on analysis) who were seen at the Vancouver Falls Prevention Clinic who had a history of at least one fall in the previous 12 months. We compared the responsiveness of the EuroQol-5 Domain-3 Level (EQ-5D-3L) and the index of capability for older adults (ICECAP-O) by examining changes in these measures over time (i.e., over 6 and 12 months) and by examining whether their changes varied as a function of having experienced 2 or more falls over 6 and 12 months. Only the ICECAP-O showed a significant change over time from baseline through 12 months; however, neither measure showed change that exceeded the standard error of the mean. Both measures were responsive to falls that occurred during the first 6 months of the study (p < .05). These effects appeared to be amplified among individuals identified as having mild cognitive impairment (MCI) at baseline (p < .01). Additionally, the EQ-5D-3L was responsive among fallers who did not have MCI as well as individuals with MCI who did not fall (p < .05). This study provides initial evidence suggesting that the EQ-5D-3L is generally more responsive, particularly during the first 6 months of falls tracking among older adults at risk of future mobility impairment.

  7. Sonochemical synthesis of pyrido[2,3-d:6,5-d']-dipyrimidines catalyzed by [HNMP]+[HSO4]-and their antimicrobial activity studies.

    Science.gov (United States)

    Naeimi, Hossein; Didar, Asieh; Rashid, Zahra; Zahraie, Zohreh

    2017-07-01

    In this study, the one-pot four-component reaction of aromatic aldehyde, 2-thiobarbituric acid, ammonium acetate in the presence of a catalytic amount of [H-NMP] + [HSO 4 ] - under ultrasonic irradiation in water is reported. In the present procedure, the pyrido[2,3-d:6,5-d']dipyrimidine derivatives were purely produced as valuable products. The process proved to be simple, environmentally friendly, efficient and high to excellent yielding. Moreover, some of the synthetic compounds were investigated and revealed important antimicrobial activity of prepared products.

  8. Responsiveness of the EuroQol EQ-5D and Hospital Anxiety and Depression Scale (HADS) in rheumatoid arthritis patients receiving tocilizumab.

    Science.gov (United States)

    Traki, L; Rostom, S; Tahiri, L; Bahiri, R; Harzy, T; Abouqal, R; Hajjaj-Hassouni, N

    2014-08-01

    The aim of this study was to assess the responsiveness to change of the quality of life evaluated by the EuroQol Five Dimensions Questionnaire (EQ-5D) and Hospital Anxiety and Depression Scale (HADS) after biological treatment in a population of rheumatoid arthritis patients. A cohort of patients with RA (n = 29) treated with tocilizumab (TCZ) were analyzed in the study. The inclusion criteria were patients aged between 18 and 65 years, fulfilling American College of Rheumatology 1987 criteria for RA. All patients had inadequate response to methotrexate and with no prior biologic exposure. They were evaluated clinically including Disease Activity Score 28 (DAS28), and the European Quality of Life 5 Dimensions (EQ-5D) to measure the quality of life, and HAD assessed the anxiety and depression status at the initiation of treatment with anti-IL 6 receptor antibody agent and after 6 months. Sensitivity to change was quantified by the effect size (ES) before and after the treatment with TCZ. Among 29 patients with RA included in the study, 25 were females and 4 males. The mean age was 42 years ± 13.4 (SD). Three patients were excluded from the study before 24 weeks because of serious side effects, and five have missing data. The study population exhibited significant decreases in all measures of disease activity at 24 weeks. Physical activity expressed by the Health Assessment Questionnaire (HAQ) score increased through the observation period (for all p < 0.001). Sensitivity to change was high for the VAS and EQ-5D (ES 1.58 and 1.36, respectively) but only moderate for the HAD anxiety component (ES = 0.70) and small for the HAD depression component (ES = 0.4). The EQ-5D and VAS were more responsive than HADS to evaluate the quality of life on patient with RA treated with TCZ.

  9. Formation of a covalent complex between the 80,000-dalton adenovirus terminal protein and 5'-dCMP in vitro.

    OpenAIRE

    Lichy, J H; Horwitz, M. S.; Hurwitz, J

    1981-01-01

    An in vitro adenovirus DNA replication system catalyzed the formation of a covalent complex between an 80,000-dalton protein and 5'-dCMP in the presence of [alpha-32P-dCTP, MgCl2, ATP, and adenovirus (Ad) DNA with a protein covalently bound to the 5' end of each strand (Ad DNA-prot). The requirement for Ad DNA-prot in this reaction was similar to that for in vitro DNA replication. When dATP, dTTP, and the 2',3'-dideoxynucleoside triphosphate (ddNTP) ddGTP were included in the reaction mixture...

  10. Lithium enrichment in intracontinental rhyolite magmas leads to Li deposits in caldera basins

    OpenAIRE

    Benson, Thomas R.; Coble, Matthew A.; Rytuba, James J.; Mahood, Gail A.

    2017-01-01

    The omnipresence of lithium-ion batteries in mobile electronics, and hybrid and electric vehicles necessitates discovery of new lithium resources to meet rising demand and to diversify the global lithium supply chain. Here we demonstrate that lake sediments preserved within intracontinental rhyolitic calderas formed on eruption and weathering of lithium-enriched magmas have the potential to host large lithium clay deposits. We compare lithium concentrations of magmas formed in a variety of te...

  11. Effects of N and P enrichment on competition between phytoplankton and benthic algae in shallow lakes: a mesocosm study.

    Science.gov (United States)

    Zhang, Xiufeng; Mei, Xueying; Gulati, Ramesh D; Liu, Zhengwen

    2015-03-01

    Competition for resources between coexisting phytoplankton and benthic algae, but with different habitats and roles in functioning of lake ecosystems, profoundly affects dynamics of shallow lakes in the process of eutrophication. An experiment was conducted to test the hypothesis that combined enrichment with nitrogen (N) and phosphorus (P) would be a greater benefit to phytoplankton than benthic algae. The growth of phytoplankton and benthic algae was measured as chlorophyll a (Chl a) in 12 shallow aquatic mesocosms supplemented with N, P, or both. We found that enrichment with N enhanced growth of benthic algae, but not phytoplankton. P enrichment had a negative effect on benthic algal growth, and no effect on the growth of phytoplankton. N+P enrichment had a negative effect on benthic algae, but enhanced the growth of phytoplankton, thus reducing the proportion of benthic algae contributing to the combined biomass of these two groups of primary producers. Thus, combined N+P enrichment is more favorable to phytoplankton in competition with benthic algae than enrichment with either N or P alone. Our study indicates that combined enrichment with N+P promotes the dominance of phytoplankton over benthic algae, with consequences for the trophic dynamics of shallow lake ecosystems.

  12. Simulating Isotope Enrichment by Gaseous Diffusion

    Science.gov (United States)

    Reed, Cameron

    2015-04-01

    A desktop-computer simulation of isotope enrichment by gaseous diffusion has been developed. The simulation incorporates two non-interacting point-mass species whose members pass through a cascade of cells containing porous membranes and retain constant speeds as they reflect off the walls of the cells and the spaces between holes in the membranes. A particular feature is periodic forward recycling of enriched material to cells further along the cascade along with simultaneous return of depleted material to preceding cells. The number of particles, the mass ratio, the initial fractional abundance of the lighter species, and the time between recycling operations can be chosen by the user. The simulation is simple enough to be understood on the basis of two-dimensional kinematics, and demonstrates that the fractional abundance of the lighter-isotope species increases along the cascade. The logic of the simulation will be described and results of some typical runs will be presented and discussed.

  13. REEF: searching REgionally Enriched Features in genomes

    Directory of Open Access Journals (Sweden)

    Danieli Gian Antonio

    2006-10-01

    Full Text Available Abstract Background In Eukaryotic genomes, different features including genes are not uniformly distributed. The integration of annotation information and genomic position of functional DNA elements in the Eukaryotic genomes opened the way to test novel hypotheses of higher order genome organization and regulation of expression. Results REEF is a new tool, aimed at identifying genomic regions enriched in specific features, such as a class or group of genes homogeneous for expression and/or functional characteristics. The method for the calculation of local feature enrichment uses test statistic based on the Hypergeometric Distribution applied genome-wide by using a sliding window approach and adopting the False Discovery Rate for controlling multiplicity. REEF software, source code and documentation are freely available at http://telethon.bio.unipd.it/bioinfo/reef/. Conclusion REEF can aid to shed light on the role of organization of specific genomic regions in the determination of their functional role.

  14. Challenges when developing omega-3 enriched foods

    Directory of Open Access Journals (Sweden)

    JACOBSEN Charlotte

    2010-07-01

    Full Text Available Due to the polyunsaturated nature of omega-3 fatty acids, lipid oxidation is a major challenge when developing omega-3 enriched foods. In multiphase food systems, several factors can affect lipid oxidation and efficacy of antioxidants, added to prevent lipid oxidation. This review discusses the influence of important factors such as oil quality, delivery systems for omega-3 fatty acids, processing conditions, composition of the food matrix on lipid oxidation in different omega-3 enriched foods (milk, yoghurt, mayonnaise and mayonnaise-based salads, dressing, energy bar and fish paté. Moreover, the effect of different antioxidants (tocopherol, EDTA, lactoferrin, caffeic acid, ascorbic acid, ascorbyl palmitate, propyl gallate, gallic acid, as well as lipophilized antioxidants is compared in different food systems.

  15. Challenges when developing omega-3 enriched foods

    DEFF Research Database (Denmark)

    Jacobsen, Charlotte

    2010-01-01

    Due to the polyunsaturated nature of omega-3 fatty acids, lipid oxidation is a major challenge when developing omega-3 enriched foods. In multiphase food systems, several factors can affect lipid oxidation and efficacy of antioxidants, added to prevent lipid oxidation. This review discusses...... the influence of important factors such as oil quality, delivery systems for omega-3 fatty acids, processing conditions, composition of the food matrix on lipid oxidation in different omega-3 enriched foods (milk, yoghurt, mayonnaise and mayonnaise-based salads, dressing, energy bar and fish paté). Moreover......, the effect of different antioxidants (tocopherol, EDTA, lactoferrin, caffeic acid, ascorbic acid, ascorbyl palmitate, propyl gallate, gallic acid, as well as lipophilized antioxidants) is compared in different food systems....

  16. Supersymmetrizing 5d instanton operators

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez-Gomez, Diego; Schmude, Johannes [Department of Physics, Universidad de Oviedo,Avda. Calvo Sotelo 18, 33007, Oviedo (Spain)

    2015-03-23

    We construct a supersymmetric version of instanton operators in five-dimensional Yang-Mills theories. This is possible by considering a five-dimensional generalization of the familiar four-dimensional topologically twisted theory, where the gauge configurations corresponding to instanton operators are supersymmetric.

  17. Minimal unitary representation of 5d superconformal algebra F(4 and AdS6/CFT5 higher spin (super-algebras

    Directory of Open Access Journals (Sweden)

    Sudarshan Fernando

    2015-01-01

    Full Text Available We study the minimal unitary representation (minrep of SO(5,2, obtained by quantization of its geometric quasiconformal action, its deformations and supersymmetric extensions. The minrep of SO(5,2 describes a massless conformal scalar field in five dimensions and admits a unique “deformation” which describes a massless conformal spinor. Scalar and spinor minreps of SO(5,2 are the 5d analogs of Dirac's singletons of SO(3,2. We then construct the minimal unitary representation of the unique 5d superconformal algebra F(4 with the even subalgebra SO(5,2×SU(2. The minrep of F(4 describes a massless conformal supermultiplet consisting of two scalar and one spinor fields. We then extend our results to the construction of higher spin AdS6/CFT5 (super-algebras. The Joseph ideal of the minrep of SO(5,2 vanishes identically as operators and hence its enveloping algebra yields the AdS6/CFT5 bosonic higher spin algebra directly. The enveloping algebra of the spinor minrep defines a “deformed” higher spin algebra for which a deformed Joseph ideal vanishes identically as operators. These results are then extended to the construction of the unique higher spin AdS6/CFT5 superalgebra as the enveloping algebra of the minimal unitary realization of F(4 obtained by the quasiconformal methods.

  18. Quantum anomalous Hall phase and half-metallic phase in ferromagnetic (111) bilayers of 4 d and 5 d transition metal perovskites

    Science.gov (United States)

    Chandra, Hirak Kumar; Guo, Guang-Yu

    2017-04-01

    Extraordinary electronic phases can form in artificial oxide heterostructures, which will provide a fertile ground for new physics and also give rise to novel device functions. Based on a systematic first-principles density functional theory study of the magnetic and electronic properties of the (111) superlattices (ABO3) 2/(AB'O3)10 of 4 d and 5 d transition metal perovskite (B = Ru, Rh, Ag, Re, Os, Ir, Au; AB'O3=LaAlO3 , SrTiO3) , we demonstrate that due to quantum confinement, bilayers (LaBO3)2 (B = Ru, Re, Os) and (SrBO3)2 (B = Rh, Os, Ir) are ferromagnetic with ordering temperatures up to room temperature. In particular, bilayer (LaOsO3)2 is an exotic spin-polarized quantum anomalous Hall insulator, while the other ferromagnetic bilayers are metallic with large Hall conductances comparable to the conductance quantum. Furthermore, bilayers (LaRuO3)2 and (SrRhO3)2 are half metallic, while the bilayer (SrIrO3)2 exhibits a peculiar colossal magnetic anisotropy. Our findings thus show that 4 d and 5 d metal perovskite (111) bilayers are a class of quasi-two-dimensional materials for exploring exotic quantum phases and also for advanced applications such as low-power nanoelectronics and oxide spintronics.

  19. A novel 2.5D culture platform to investigate the role of stiffness gradients on adhesion-independent cell migration.

    Science.gov (United States)

    Pebworth, Mark-Phillip; Cismas, Sabrina A; Asuri, Prashanth

    2014-01-01

    Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness. To better understand the effects of stiffness gradients on cell migration, we developed a 2.5D cell culture platform where cells are sandwiched between stiff tissue culture plastic and soft alginate hydrogel. Under these conditions, we observed migration of cells from the underlying stiff substrate into the alginate matrix. Observation of migration into alginate in the presence of integrin inhibition as well as qualitative microscopic analyses suggested an adhesion-independent cell migration mode. Observed migration was dependent on alginate matrix stiffness and the RhoA-ROCK-myosin-II pathway; inhibitors specifically targeting ROCK and myosin-II arrested cell migration. Collectively, these results demonstrate the utility of the 2.5D culture platform to advance our understanding of the effects of stiffness gradients and mechanotransductive signaling on adhesion-independent cell migration.

  20. Emergence of non-Fermi liquid behaviors in 5d perovskite SrIrO{sub 3} thin films: Interplay between correlation, disorder, and spin-orbit coupling

    Energy Technology Data Exchange (ETDEWEB)

    Biswas, Abhijit [Department of Physics, POSTECH, Pohang 790-784 (Korea, Republic of); Kim, Ki-Seok [Department of Physics, POSTECH, Pohang 790-784 (Korea, Republic of); Institute of Edge of Theoretical Science (IES), POSTECH, Pohang 790-784 (Korea, Republic of); Jeong, Yoon H., E-mail: yhj@postech.ac.kr [Department of Physics, POSTECH, Pohang 790-784 (Korea, Republic of)

    2016-02-15

    We investigate the effects of compressive strain on the electrical resistivity of 5d iridium based perovskite SrIrO{sub 3} by depositing epitaxial films of thickness 35 nm on various substrates such as GdScO{sub 3} (110), DyScO{sub 3} (110), and SrTiO{sub 3} (001). Surprisingly, we find anomalous transport behaviors as expressed by ρ∝T{sup ε} in the temperature dependent resistivity, where the temperature exponent ε evolves continuously from 4/5 to 1 and to 3/2 with an increase of compressive strain. Furthermore, magnetoresistance always remains positive irrespective of resistivity upturns at low temperatures. These observations imply that the delicate interplay between correlation and disorder in the presence of strong spin-orbit coupling is responsible for the emergence of the non-Fermi liquid behaviors in 5d perovskite SrIrO{sub 3} thin films. We offer a theoretical framework for the interpretation of the experimental results. - Highlights: • We studied the effect of compressive strain on the perovskite SrIrO{sub 3} thin films. • We revealed non-Fermi liquid behaviors in the transport properties. • Irrespective of weak localization effects, magnetoresistance remains positive. • Mott-Anderson-Griffiths scenario is proposed to account for the NFL behaviors.

  1. Short Wavelength Electromagnetic Perturbations Excited Near the Solar Probe Plus Spacecraft in the Inner Heliosphere: 2.5D Hybrid Modeling

    Science.gov (United States)

    Lipatov, Alexander S.; Sittler, Edward C.; Hartle, Richard E.; Cooper, John F.

    2011-01-01

    A 2.5D numerical plasma model of the interaction of the solar wind (SW) with the Solar Probe Plus spacecraft (SPPSC) is presented. These results should be interpreted as a basic plasma model derived from the SW-interaction with the spacecraft (SC), which could have consequences for both plasma wave and electron plasma measurements on board the SC in the inner heliosphere. Compression waves and electric field jumps with amplitudes of about 1.5 V/m and (12-18) V/m were also observed. A strong polarization electric field was also observed in the wing of the plasma wake. However, 2.5D hybrid modeling did not show excitation of whistler/Alfven waves in the upstream connected with the bidirectional current closure that was observed in short-time 3D modeling SPPSC and near a tether in the ionosphere. The observed strong electromagnetic perturbations may be a crucial point in the electromagnetic measurements planned for the future Solar Probe Plus (SPP) mission. The results of modeling electromagnetic field perturbations in the SW due to shot noise in absence of SPPSC are also discussed.

  2. A New Adaptive Response Surface Model for Reliability Analysis of 2.5D C/SiC Composite Turbine Blade

    Science.gov (United States)

    Chang, Yaning; Sun, Zhigang; Sun, Weiyi; Song, Yingdong

    2017-11-01

    In order to calculate the failure probability of complex structures such as a 2.5D/SiC composites turbine blade and improve the structure safety, a new adaptive model of Response Surface (RS) analysis has been developed in this paper, which can improve the computational efficiency of structural failure problem while ensure the accuracy. The Gaussian Process Regression (GPR) theory was used to establish the RS and reconstruct the performance function of structure. And, an Adaptive Latin hypercube Sampling (ALHS) strategy was adopted in the process of establishing and correcting the RS. Finally the Direct Simulation Monte Carlo(DSMC)was utilized to calculate the failure probability of the performance function replacing the complex structure. Two numerical examples were calculated to validate the accuracy and computational efficiency of the proposed method. Additionally the finite element stress analysis results of 2.5D C/SiC composite turbine blade were used to structural reliability analysis by the proposed method. The approach in this paper provides a new way to evaluate the risk of the complex structures.

  3. Joule heating induced thermomigration failure in un-powered microbumps due to thermal crosstalk in 2.5D IC technology

    Energy Technology Data Exchange (ETDEWEB)

    Li, Menglu; Tu, K. N., E-mail: kntu@ucla.edu [Department of Materials Science and Engineering, UCLA, Los Angeles, California 90095-1595 (United States); Kim, Dong Wook; Gu, Sam [Qualcomm, San Diego, California 92121 (United States); Parkinson, Dilworth Y.; Barnard, Harold [Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States)

    2016-08-21

    Thermal-crosstalk induced thermomigration failure in un-powered microbumps has been found in 2.5D integrated circuit (IC) circuit. In 2.5D IC, a Si interposer was used between a polymer substrate and a device chip which has transistors. The interposer has no transistors. If transistors are added to the interposer chip, it becomes 3D IC. In our test structure, there are two Si chips placed horizontally on a Si interposer. The vertical connections between the interposer and the Si chips are through microbumps. We powered one daisy chain of the microbumps under one Si chip; however, the un-powered microbumps in the neighboring chip are failed with big holes in the solder layer. We find that Joule heating from the powered microbumps is transferred horizontally to the bottom of the neighboring un-powered microbumps, and creates a large temperature gradient, in the order of 1000 °C/cm, through the un-powered microbumps in the neighboring chip, so the latter failed by thermomigration. In addition, we used synchrotron radiation tomography to compare three sets of microbumps in the test structure: microbumps under electromigration, microbumps under thermomigration, and microbumps under a constant temperature thermal annealing. The results show that the microbumps under thermomigration have the largest damage. Furthermore, simulation of temperature distribution in the test structure supports the finding of thermomigration.

  4. Estimation of Ce 4f-5d Interaction by Analysis of Partial Fluorescence Yield at the Ce L3 Edge of CeO2

    Science.gov (United States)

    Tonai, Hironori; Sasabe, Norimasa; Uozumi, Takayuki; Kawamura, Naomi; Mizumaki, Masaichiro

    2017-09-01

    Partial fluorescence yield (PFY) spectroscopy, which corresponds to a high-resolution version of the X-ray absorption spectroscopy (XAS), is experimentally performed at the Ce L3 edge of CeO2, and the result is theoretically analyzed using an impurity Anderson model (IAM). In order to estimate the Ce 4f-5d interaction Ufd, we employ a semi-empirical IAM framework based on the local density approximation+U method; Slater-Koster parameters describing the valence of CeO2 are estimated by band mapping within the linear combination of atomic orbitals scheme, and the resulting realistic valence structure is considered in the IAM analysis. The global structure of the PFY-XAS result, which consists of the Ce 2p3/2 → 5d dipole transition and the Ce 2p3/2 → 4f quadrupole transition, is excellently reproduced by the calculation. The Ufd value is estimated to be 3.0 eV. We emphasize that the sensitivity of PFY-XAS to Ufd makes it a good ruler for obtaining the Ufd values of Ce compounds.

  5. Automated Information Enrichment for a Better Search

    OpenAIRE

    José Luis Preza

    2016-01-01

    The process of adding the Metadata when uploading a digital object onto a repository is usually manual. This means that the user has to have already at hand the keywords and all the other information about the asset. This paper addresses the possibility of enriching the “manual metadata” by generating automated metadata using the cognitive services provided by technologies like IBM Watson platform. The cognitive computing services offered by IBM Watson automatically generate Semantic Data (in...

  6. Supply of enriched uranium for research reactors

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, H. [NUKEM GmbH, Alzenau (Germany)

    1997-08-01

    Since the RERTR-meeting In Newport/USA in 1990 the author delivered a series of papers in connection with the fuel cycle for research reactors dealing with its front-end. In these papers the author underlined the need for unified specifications for enriched uranium metal suitable for the production of fuel elements and made proposals with regard to the re-use of in Europe reprocessed highly enriched uranium. With regard to the fuel cycle of research reactors the research reactor community was since 1989 more concentrating on the problems of its back-end since the USA stopped the acceptance of spent research reactor fuel on December 31, 1988. Now, since it is apparent that these back-end problem have been solved by AEA`s ability to reprocess and the preparedness of the USA to again accept physically spent research reactor fuel the author is focusing with this paper again on the front-end of the fuel cycle on the question whether there is at all a safe supply of low and high enriched uranium for research reactors in the future.

  7. Rare-earth elements enrichment of Pacific seafloor sediments: the view from volcanic islands of Polynesia

    Science.gov (United States)

    Melleton, Jérémie; Tuduri, Johann; Pourret, Olivier; Bailly, Laurent; Gisbert, Thierry

    2014-05-01

    Rare-earth elements (REEs) are key metals for «green» technologies such as energy saving lamps or permanent magnets used in, e.g., wind turbines, hard disk drives, portable phone or electric or hybrid vehicles. Since several years, world demand for these metals is therefore drastically increasing. The quasi-monopolistic position of China, which produces around 95 % of global REEs production, generates risks for the industries that depend on a secure supply of REEs. In response, countries are developing and diversifying their supply sources, with new mining projects located outside China and efforts in the area of REEs recycling. Most of these projects focus on deposits related to carbonatites and alkaline-peralkaline magmatism, which are generally enriched in light REEs (LREEs) compared to the heavy REEs (HREEs)-enriched deposits of the ion-adsorption types, located in southern China. However, a recent study revealed new valuable resources corresponding to seafloor sediments located in the south-eastern and north-central Pacific. The deep-sea mud described by these authors show a higher HREE/LREE ratio than ion-adsorption deposits, a feature which significantly increases their economic interest. The authors suggest mid-ocean ridge hydrothermal activity as an explanation to this anomalous enrichment. However, several contributions have documented considerable REEs enrichment in basalts and peridotitic xenoliths from French Polynesia. Several arguments have been exposed in favour of a supergene origin, with a short migration, suggesting that REEs were collected from weathered basalts. The Tahaa volcanic island (Sous-le-Vent Island, Society Archipelago, French Polynesia) is the first location where such enrichment has been described. New petrographic and mineralogical investigations confirm a supergene mobilization of this abnormal occurrence. REE-bearing minerals (mainly phosphates of the rhabdophane group) are primarily located within basalt vesicles but also in

  8. 75 FR 21680 - GE-Hitachi Global Laser Enrichment LLC;

    Science.gov (United States)

    2010-04-26

    ... special nuclear material and to enrich natural uranium to a maximum of 8 percent U-235 by a laser-based... authorization to construct a uranium enrichment facility, a mandatory hearing is required. The Board is...

  9. Enrichment of omnivorous cercozoan nanoflagellates from coastal Baltic Sea waters.

    Directory of Open Access Journals (Sweden)

    Kasia Piwosz

    Full Text Available Free-living nano-sized flagellates are important bacterivores in aquatic habitats. However, some slightly larger forms can also be omnivorous, i.e., forage upon both bacterial and eukaryotic resources. This hitherto largely ignored feeding mode may have pronounced implications for the interpretation of experiments about protistan bacterivory. We followed the response of an uncultured group of omnivorous cercozoan nanoflagellates from the Novel Clade 2 (Cerc_BAL02 to experimental food web manipulation in samples from the Gulf of Gdańsk (Southern Baltic Sea. Seawater was either prefiltered through 5 µm filters to exclude larger predators of nanoflagellates (F-treatment, or prefiltered and subsequently 1∶10 diluted with sterile seawater (F+D-treatment to stimulate the growth of both, flagellates and bacteria. Initially, Cerc_BAL02 were rapidly enriched under both conditions. They foraged on both, eukaryotic prey and bacteria, and were highly competitive at low concentrations of food. However, these omnivores were later only successful in the F+D treatment, where they eventually represented almost one fifth of all aplastidic nanoflagellates. By contrast, their numbers stagnated in the F-treatment, possibly due to top-down control by a concomitant bloom of other, unidentified flagellates. In analogy with observations about the enrichment of opportunistically growing bacteria in comparable experimental setups we suggest that the low numbers of omnivorous Cerc_Bal02 flagellates in waters of the Gulf of Gdańsk might also be related to their vulnerability to grazing pressure.

  10. 21 CFR 139.122 - Enriched nonfat milk macaroni products.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Enriched nonfat milk macaroni products. 139.122... Macaroni and Noodle Products § 139.122 Enriched nonfat milk macaroni products. (a) Each of the enriched macaroni products made with nonfat milk for which a definition and standard of identity is prescribed by...

  11. 78 FR 75579 - Low Enriched Uranium From France

    Science.gov (United States)

    2013-12-12

    ... COMMISSION Low Enriched Uranium From France Determination On the basis of the record \\1\\ developed in the... antidumping duty order on low enriched uranium from France would be likely to lead to continuation or...), entitled Low Enriched Uranium from France: Investigation No. 731-TA-909 (Second Review). By order of the...

  12. A compact tritium enrichment unit for large sample volumes with automated re-filling and higher enrichment factor.

    Science.gov (United States)

    Kumar, B; Han, L-F; Wassenaar, L I; Klaus, P M; Kainz, G G; Hillegonds, D; Brummer, D; Ahmad, M; Belachew, D L; Araguás, L; Aggarwal, P

    2016-12-01

    Tritium (3H) in natural waters is a powerful tracer of hydrological processes, but its low concentrations require electrolytic enrichment before precise measurements can be made with a liquid scintillation counter. Here, we describe a newly developed, compact tritium enrichment unit which can be used to enrich up to 2L of a water sample. This allows a high enrichment factor (>100) for measuring low 3H contents of enriched samples. The enriched residual sample is retrieved from the cell under vacuum by cryogenic distillation at -20°C and the tritium enrichment factor for each sample is accurately determined by measuring pre- and post- enrichment 2H concentrations with laser spectrometry. Copyright © 2016. Published by Elsevier Ltd.

  13. Information resources

    Science.gov (United States)

    Friend, Milton; Franson, J. Christian; Friend, Milton; Gibbs, Samantha E.J.; Wild, Margaret A.

    2015-10-19

    During recent decades, natural resources agency personnel and others involved with the management and stewardship of wildlife have experienced an increasing need to access information and obtain technical assistance for addressing a diverse array of wildlife disease issues. This Chapter provides a broad overview of selected sources for obtaining supplemental information and technical assistance for addressing wildlife disease issues in North America. Specifically, examples of existing major wildlife disease programs focusing on free-ranging wildlife populations are highlighted; training opportunities for enhancing within-agency wildlife disease response are identified; a selected reading list of wildlife disease references is provided; and selected Web sites providing timely information on wildlife disease are highlighted. No attempt is made to detail all the North American programs and capabilities that address disease in free-ranging wildlife populations. Instead, this Chapter is focused on enhancing awareness of the types of capabilities that exist as potential sources for assistance and collaboration between wildlife conservation agency personnel and others in addressing wildlife disease issues.

  14. Mapping health assessment questionnaire disability index (HAQ-DI) score, pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) onto the EuroQol-5D (EQ-5D) utility score with the KORean Observational study Network for Arthritis (KORONA) registry data.

    Science.gov (United States)

    Kim, Hye-Lin; Kim, Dam; Jang, Eun Jin; Lee, Min-Young; Song, Hyun Jin; Park, Sun-Young; Cho, Soo-Kyung; Sung, Yoon-Kyoung; Choi, Chan-Bum; Won, Soyoung; Bang, So-Young; Cha, Hoon-Suk; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Jun, Jae-Bum; Kim, Jinseok; Kim, Seong-Kyu; Kim, Tae-Hwan; Kim, Tae-Jong; Koh, Eunmi; Lee, Hwajeong; Lee, Hye-Soon; Lee, Jisoo; Lee, Shin-Seok; Lee, Sung Won; Park, Sung-Hoon; Shim, Seung-Cheol; Yoo, Dae-Hyun; Yoon, Bo Young; Bae, Sang-Cheol; Lee, Eui-Kyung

    2016-04-01

    The aim of this study was to estimate the mapping model for EuroQol-5D (EQ-5D) utility values using the health assessment questionnaire disability index (HAQ-DI), pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) in a large, nationwide cohort of rheumatoid arthritis (RA) patients in Korea. The KORean Observational study Network for Arthritis (KORONA) registry data on 3557 patients with RA were used. Data were randomly divided into a modeling set (80 % of the data) and a validation set (20 % of the data). The ordinary least squares (OLS), Tobit, and two-part model methods were employed to construct a model to map to the EQ-5D index. Using a combination of HAQ-DI, pain VAS, and DAS28, four model versions were examined. To evaluate the predictive accuracy of the models, the root-mean-square error (RMSE) and mean absolute error (MAE) were calculated using the validation dataset. A model that included HAQ-DI, pain VAS, and DAS28 produced the highest adjusted R (2) as well as the lowest Akaike information criterion, RMSE, and MAE, regardless of the statistical methods used in modeling set. The mapping equation of the OLS method is given as EQ-5D = 0.95-0.21 × HAQ-DI-0.24 × pain VAS/100-0.01 × DAS28 (adjusted R (2) = 57.6 %, RMSE = 0.1654 and MAE = 0.1222). Also in the validation set, the RMSE and MAE were shown to be the smallest. The model with HAQ-DI, pain VAS, and DAS28 showed the best performance, and this mapping model enabled the estimation of an EQ-5D value for RA patients in whom utility values have not been measured.

  15. Room-temperature InAs/InP Quantum Dots laser operation based on heterogeneous "2.5 D" Photonic Crystal.

    Science.gov (United States)

    Ben Bakir, Badhise; Seassal, Christian; Letartre, Xavier; Regreny, Philippe; Gendry, Michel; Viktorovitch, Pierre; Zussy, Marc; Di Cioccio, Léa; Fedeli, Jean-Marc

    2006-10-02

    The authors report on the design, fabrication and operation of heterogeneous and compact "2.5 D" Photonic Crystal microlaser with a single plane of InAs quantum dots as gain medium. The high quality factor photonic structures are tailored for vertical emission. The devices consist of a top two-dimensional InP Photonic Crystal Slab, a SiO(2) bonding layer, and a bottom high index contrast Si/SiO(2) Bragg mirror deposited on a Si wafer. Despite the fact that no more than about 5% of the quantum dots distribution effectively contribute to the modal gain, room-temperature lasing operation, around 1.5 microm, was achieved by photopumping. A low effective threshold, on the order of 350 microW, and a spontaneous emission factor, over 0.13, could be deduced from experiments.

  16. Does clinical remission lead to normalization of EQ-5D in patients with rheumatoid arthritis and is selection of remission criteria important?

    DEFF Research Database (Denmark)

    Linde, Louise; Sørensen, Jan; Østergaard, Mikkel

    2010-01-01

    patient as the difference from the age and sex-matched general population and adjusted for age, marital status, education, body mass index, smoking, exercise habits, disease duration, IgM-rheumatoid factor status, joint surgery, extraarticular features, treatment, and comorbidity in multiple linear...... regression models. RESULTS: 37% vs 22% fulfilled the DAS28 and CDAI remission criteria, respectively. The DeltaEQ-5D values for women/men in clinical remission were DAS28 0.05/0.06 vs CDAI 0.01/0.02; low disease activity: DAS28 0.12/0.13 vs CDAI 0.11/0.14; moderate disease activity: DAS28 0.18/0.20 vs CDAI 0...

  17. Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study.

    Science.gov (United States)

    Ewida, Menna A; Abou El Ella, Dalal A; Lasheen, Deena S; Ewida, Heba A; El-Gazzar, Yomna I; El-Subbagh, Hussein I

    2017-10-01

    A new series of 1,3-thiazoles and thiazolo[4,5-d]pyridazine both bearing the 2-thioureido function were designed, synthesized and evaluated for their invitro DHFR inhibition and antitumor activities. Compound 26 proved to be the most active DHFR inhibitor (IC50 of 0.06μM). Compound 4, 20 and 21 showed in vitro antitumor activity against a collection of cancer cell lines. Compound 26 proved lethal to HS 578T breast cancer cell line with IC50 value of 0.8μM, inducing cell cycle arrest and apoptosis. Molecular modeling studies concluded that recognition with key amino acids Phe 31 and Arg 22 is essential for DHFR binding. The obtained model could be useful for the development of new class of DHFR inhibitors. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Health-related quality of life: validity, reliability, and responsiveness of SF-36, 15D, EQ-5D RAQoL, and HAQ in patients with rheumatoid arthritis

    DEFF Research Database (Denmark)

    Linde, L.; Sørensen, J.; Østergaard, Morten

    2008-01-01

    OBJECTIVE: To compare validity, reliability, and responsiveness of generic and disease specific health-related quality of life (HRQOL) instruments in rheumatoid arthritis (RA). METHODS: Two samples of patients completed the Medical Outcomes Study Short Form-36 Health Survey (SF-36), EuroQol (EQ)-5D......, 15D, Rheumatoid Arthritis Quality of Life Scale (RAQoL), Health Assessment Questionnaire (HAQ), and visual analog scales (VAS) for pain, fatigue, and global RA. Validity (convergent, discriminant, and known-groups) was evaluated in a cross-section of 200 patients. Reliability was evaluated...... questionnaires (at 2 weeks and 6 months) included questions about changes in health status since baseline. RESULTS: The cross-sectional sample included 77% women, median age 57 years (range 19-87), disease duration 6 years (0-58), with Disease Activity Score 28-joint count (DAS28) of 3.10 (1...

  19. Quantum tunneling of spin-1 particles from a 5D Einstein-Yang-Mills-Gauss-Bonnet black hole beyond semiclassical approximation

    Science.gov (United States)

    Jusufi, K.

    2016-12-01

    In the present paper we study the Hawking radiation as a quantum tunneling effect of spin-1 particles from a five-dimensional, spherically symmetric, Einstein-Yang-Mills-Gauss-Bonnet (5D EYMGB) black hole. We solve the Proca equation (PE) by applying the WKB approximation and separation of variables via Hamilton-Jacobi (HJ) equation which results in a set of five differential equations, and reproduces, in this way, the Hawking temperature. In the second part of this paper, we extend our results beyond the semiclassical approximation. In particular, we derive the logarithmic correction to the entropy of the EYMGB black hole and show that the quantum corrected specific heat indicates the possible existence of a remnant.

  20. 75 FR 10525 - In the Matter of: AREVA Enrichment Services, LLC (Eagle Rock Enrichment Facility) and All Other...

    Science.gov (United States)

    2010-03-08

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION In the Matter of: AREVA Enrichment Services, LLC (Eagle Rock Enrichment Facility) and All Other... Immediately) I AREVA Enrichment Services, LLC (AES), has applied to the U.S. Nuclear Regulatory Commission...

  1. A coupled SAFE-2.5D BEM approach for the dispersion analysis of damped leaky guided waves in embedded waveguides of arbitrary cross-section.

    Science.gov (United States)

    Mazzotti, M; Bartoli, I; Marzani, A; Viola, E

    2013-09-01

    The paper presents a Semi-Analytical Finite Element (SAFE) formulation coupled with a 2.5D Boundary Element Method (BEM) for the computation of the dispersion properties of viscoelastic waveguides with arbitrary cross-section and embedded in unbounded isotropic viscoelastic media. Attenuation of guided modes is described through the imaginary component of the axial wavenumber, which accounts for material damping, introduced via linear viscoelastic constitutive relations, as well as energy loss due to radiation of bulk waves in the surrounding media. Energy radiation is accounted in the SAFE model by introducing an equivalent dynamic stiffness matrix for the surrounding medium, which is derived from a regularized 2.5D boundary element formulation. The resulting dispersive wave equation is configured as a nonlinear eigenvalue problem in the complex axial wavenumber. The eigenvalue problem is reduced to a linear one inside a chosen contour in the complex plane of the axial wavenumber by using a contour integral method. Poles of leaky and evanescent modes are obtained by choosing appropriately the phase of the wavenumbers normal to the interface in compliance with the nature of the waves in the surrounding medium. Finally, the obtained eigensolutions are post-processed to compute the energy velocity and the radiated wavefield in the surrounding domain. The reliability of the method is first validated on existing results for waveguides of circular cross sections embedded in elastic and viscoelastic media. Next, the potential of the proposed numerical framework is shown by computing the dispersion properties for a square steel bar embedded in grout and for an H-shaped steel pile embedded in soil. Copyright © 2013 Elsevier B.V. All rights reserved.

  2. Pseudo 5D HN(C)N experiment to facilitate the assignment of backbone resonances in proteins exhibiting high backbone shift degeneracy

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Dinesh, E-mail: dineshcbmr@gmail.com [Centre of Biomedical Research (CBMR), SGPGIMS Campus, Raibareli Road, Lucknow 226014 (India); Raikwal, Nisha [Centre of Biomedical Research (CBMR), SGPGIMS Campus, Raibareli Road, Lucknow 226014 (India); Shukla, Vaibhav Kumar; Pandey, Himanshu; Arora, Ashish [Molecular and Structural Biology Division, CSIR, Central Drug Research Institute, Lucknow 226031 (India); Guleria, Anupam, E-mail: anuguleriaphy@gmail.com [Centre of Biomedical Research (CBMR), SGPGIMS Campus, Raibareli Road, Lucknow 226014 (India)

    2014-09-30

    Graphical abstract: - Highlights: • A reduced dimensionality experiment – referred as pseudo 5D HN(C)N- is presented. • Encodes highly resolved 5D spectral information in a 3D spectrum. • Superior in terms of peak dispersion. • Facilitates assignment of crowded HSQC spectra of moderately sized proteins. • Modulated {sup 15}N chemical shifts are used to break the amide shift degeneracy. - Abstract: Assignment of protein backbone resonances is most routinely carried out using triple resonance three-dimensional NMR experiments involving amide {sup 1}H/{sup 15}N resonances. However for intrinsically unstructured proteins, alpha-helical proteins or proteins containing several disordered fragments, the assignment becomes problematic because of high-degree of backbone shift degeneracy. In this backdrop, a novel reduced-dimensionality (RD) experiment –(5, 3)D-hNCO-CANH- is presented to facilitate/validate the sequential backbone resonance assignment in such proteins. The proposed 3D NMR experiment makes use of the modulated amide {sup 15}N chemical shifts (resulting from the joint sampling along both its indirect dimensions) to resolve the ambiguity involved in connecting the neighboring amide resonances (i.e. H{sub i}N{sub i} and H{sub i−1}N{sub i−1}) for overlapping amide-NH peaks. The experiment -in combination with routine triple resonance 3D-NMR experiments involving backbone amide ({sup 1}H/{sup 15}N) and carbon ({sup 13}C{sup α}/{sup 13}C′) chemical shifts- will serve as a powerful complementary tool to achieve the nearly complete assignment of protein backbone resonances in a time efficient manner.

  3. Work-family enrichment and psychological health

    Directory of Open Access Journals (Sweden)

    Ameeta Jaga

    2013-03-01

    Full Text Available Orientation: This study examines the beneficial aspects of the interface between work and family and its relationships with psychological health from a positive psychology perspective.Research purpose: The objective of this study was to investigate whether work-family enrichment helps to predict psychological health, specifically increased subjective well-being and decreased feelings of emotional exhaustion and depression.Motivation for the study: The burgeoning literature on the work-family interface contains little on the potentially positive benefits of maintaining work and family roles.Research approach, design and method: The authors used a descriptive research design. Employees in two national organisations in the financial retail and logistics industries completed a self-administered survey questionnaire. The authors analysed responses from those who reported both family and work responsibilities (N = 160.Main findings: Consistent with previous research, factor analysis revealed two distinct directions of work-family enrichment: from work to family (W2FE and from family to work (F2WE. Multiple regression analysis showed that F2WE explained a significant proportion of the variance in subjective wellbeing, whilst W2FE explained a significant proportion of the variance in depression and emotional exhaustion.Practical/managerial implications: The findings of this study revealed the individual and organisational benefits of fostering work-family enrichment. Contributions/value add: This study presents empirical evidence for the need to focus on the positive aspects of the work-family interface, provides further support for a positive organisational psychology perspective in organisations and hopefully will encourage further research on interventions in organisations and families.

  4. Nitrogen enrichment regulates calcium sources in forests.

    Science.gov (United States)

    Hynicka, Justin D; Pett-Ridge, Julie C; Perakis, Steven S

    2016-12-01

    Nitrogen (N) is a key nutrient that shapes cycles of other essential elements in forests, including calcium (Ca). When N availability exceeds ecosystem demands, excess N can stimulate Ca leaching and deplete Ca from soils. Over the long term, these processes may alter the proportion of available Ca that is derived from atmospheric deposition vs. bedrock weathering, which has fundamental consequences for ecosystem properties and nutrient supply. We evaluated how landscape variation in soil N, reflecting long-term legacies of biological N fixation, influenced plant and soil Ca availability and ecosystem Ca sources across 22 temperate forests in Oregon. We also examined interactions between soil N and bedrock Ca using soil N gradients on contrasting basaltic vs. sedimentary bedrock that differed 17-fold in underlying Ca content. We found that low-N forests on Ca-rich basaltic bedrock relied strongly on Ca from weathering, but that soil N enrichment depleted readily weatherable mineral Ca and shifted forest reliance toward atmospheric Ca. Forests on Ca-poor sedimentary bedrock relied more consistently on atmospheric Ca across all levels of soil N enrichment. The broad importance of atmospheric Ca was unexpected given active regional uplift and erosion that are thought to rejuvenate weathering supply of soil minerals. Despite different Ca sources to forests on basaltic vs. sedimentary bedrock, we observed consistent declines in plant and soil Ca availability with increasing N, regardless of the Ca content of underlying bedrock. Thus, traditional measures of Ca availability in foliage and soil exchangeable pools may poorly reflect long-term Ca sources that sustain soil fertility. We conclude that long-term soil N enrichment can deplete available Ca and cause forests to rely increasingly on Ca from atmospheric deposition, which may limit ecosystem Ca supply in an increasingly N-rich world. © 2016 John Wiley & Sons Ltd.

  5. A metaphor-enriched social cognition.

    Science.gov (United States)

    Landau, Mark J; Meier, Brian P; Keefer, Lucas A

    2010-11-01

    Social cognition is the scientific study of the cognitive events underlying social thought and attitudes. Currently, the field's prevailing theoretical perspectives are the traditional schema view and embodied cognition theories. Despite important differences, these perspectives share the seemingly uncontroversial notion that people interpret and evaluate a given social stimulus using knowledge about similar stimuli. However, research in cognitive linguistics (e.g., Lakoff & Johnson, 1980) suggests that people construe the world in large part through conceptual metaphors, which enable them to understand abstract concepts using knowledge of superficially dissimilar, typically more concrete concepts. Drawing on these perspectives, we propose that social cognition can and should be enriched by an explicit recognition that conceptual metaphor is a unique cognitive mechanism that shapes social thought and attitudes. To advance this metaphor-enriched perspective, we introduce the metaphoric transfer strategy as a means of empirically assessing whether metaphors influence social information processing in ways that are distinct from the operation of schemas alone. We then distinguish conceptual metaphor from embodied simulation--the mechanism posited by embodied cognition theories--and introduce the alternate source strategy as a means of empirically teasing apart these mechanisms. Throughout, we buttress our claims with empirical evidence of the influence of metaphors on a wide range of social psychological phenomena. We outline directions for future research on the strength and direction of metaphor use in social information processing. Finally, we mention specific benefits of a metaphor-enriched perspective for integrating and generating social cognitive research and for bridging social cognition with neighboring fields.

  6. Cheese bread enriched with biofortified cowpea flour

    Directory of Open Access Journals (Sweden)

    Rodrigo Barbosa Monteiro Cavalcante

    2016-02-01

    Full Text Available ABSTRACT The development and enrichment of food are of great importance not only for the industry but also to improve the population's nutrition, where you can create new products or optimize existing ones. The consumption of fortified products in the diet is an option for the control of deficiency diseases. This study aimed to develop enriched cheese bread with whole biofortified cowpea flour and evaluate their acceptance and chemical composition. Two formulations, F1 and F2, were prepared containing 5.6 and 8% of cowpea flour as a substitute for starch, respectively. To check acceptance, three sensory tests were used (Hedonic Scale, Purchase Intent, and Paired Comparison, F1 being sensory viable according to assessors, being chemically analyzed. Minerals were determined by atomic emission spectrometry with inductively coupled plasma source. The moisture was determined by drying at 105 °C, ash by calcination in muffle at 550 °C, proteins by the macro-Kjeldahl method, and lipids by hot extraction in a Soxhlet extractor. Carbohydrates were obtained by difference and the calories were calculated. The addition of cowpea increased the amounts of copper, iron, phosphorus, magnesium, manganese, and zinc, as well as protein and carbohydrate values. On the other hand, there was a reduction of the moisture concerning lipids and the total caloric value compared to the standard formulation. It was concluded , therefore, that the cowpea, a regional raw material in market expansion is presented as an option for the enrichment of baked foods that do not contain gluten, such as cheese bread.

  7. Modeling Profiles and Signatures of Enrichments

    Science.gov (United States)

    Ali, A.; Qualls, C.; Lucas, S. G.; Lombari, G.; Appenzeller, O.

    2014-12-01

    Anthropogenic and geochemical enrichment of soils and living matter have been well documented 1, 2, 3.Here we report on geochemical, anthropogenic and biological enrichments with heavy metals in Modern Peru and compared this to Modern and ancient data from New Mexico, USA. We established a signature derived from the quantities of 25 metals in various biological, fossil and soil materials. We also speculate that human adaptation to mercury toxicity may occur in remarkably short time spans during the Holocene. We found mercury concentrations in Modern pigeon feathers and llama wool from free foraging birds and animals in Albuquerque, NM, ranging from 0.006 to 0.019 mg/Kg of tissue. The values for Modern Peru ranged from 22.0 to 556 mg/Kg for the same tissues. We discovered, in 64 million-year-old fossilized plants from New Mexico (Paleocene Nacimiento Formation, San Juan Basin), a mercury concentration of 1.11 mg/Kg of fossil, whereas Modern plant material from the Rio Grande Basin in New Mexico contained no mercury. Profiling of metal content of these samples suggests that mercury is a proxy for anthropogenic rather than geochemical enrichment in the localities we examined. We found no overt signs of mercury toxicity in contemporaneous inhabitants of Huancavelica4, Peru; one of the ten most mercury-polluted places in the world and the mercury concentration in their hair is well below modern admissible levels. However, assessment of their annual scalp hair growth-rate showed marked reduction in growth (~ 5cm/yr) versus ~ 16cm/year for normal scalp hair from other continents4. This is consistent with a toxic effect of heavy metals on human metabolism and especially autonomic nervous system function in Huancavelica, Peru. Contemporaneous anthropogenic activities are known to increase heavy metal content in the biosphere with potentially toxic effects on humans. However, signs of human evolutionary adaptation to such toxins might already be evident in Peru4.

  8. Enriching Students’ Vocabulary Mastery Using Graphic Organizers

    Directory of Open Access Journals (Sweden)

    Syaifudin Latif Darmawan

    2017-04-01

    Full Text Available This action research is carried out to (1 identify whether graphic organizers enrich student’s vocabulary mastery; and (2 to describe the classroom situation when graphic organizers are employed in instructional process of vocabulary. The research is conducted in two cycles from March to May 2016/2017 in the eight years of SMP Muhammadiyah Sekampung, East lampung. The procedure of the research consists of identifying the problem, planning the action, implementing the action, observing the action, and reflecting the result of the research. Qualitative data are collected through interview, observation, questionnaire, and research diary. Quantitative data are collected through test. To analyze qualitative data, the researcher used constant comparative method. It consists of four steps: (1 comparing incidents applicable to each category; (2 Integrating categories and their properties; (3 delimiting the theory; (4 Writing the theory. Meanwhile, to analyze quantitative data, the researcher employed descriptive statistic.    The result of the research shows that using graphic organizers can enrich students’ vocabulary mastery and classroom situation. The improvement on students’ vocabulary included; a the students are able to speak English; b the students are able to understand the meaning of the text as they have a lot of vocabularies. The improvement of the classroom situation; (a students come on time in the class (b students are more motivated to join the class (c Students pay more attention in the instructional process (d students’ participation in responding the questions are high.

  9. Chemical Enrichment of the Early Solar System

    Science.gov (United States)

    Goodson, Matthew David

    Meteorites preserved from the birth of the Solar system over 4.5 billion years ago contain the chemical signature of a nearby contemporaneous stellar explosion in the form of short-lived radioisotopes (SLRs) such as Aluminum-26. Yet results from hydrodynamical models of SLR injection into the pre-Solar cloud or disk encounter a common problem: it is difficult to sufficiently mix the hot, enriched gas into the cold, dense, cloud without disrupting the formation of the Solar system. I first consider the role of numerical methods in limiting the mixing. I implement six turbulence models in the Athena hydrodynamics code. I then explore an alternative mechanism to overcome the mixing barrier: microscopic dust grains. I numerically model the interaction of a supernova remnant containing SLR-rich dust grains with a nearby molecular cloud. The results suggest that SLR transport on dust grains is a viable mechanism to explain Solar system enrichment. Finally, I attempt to constrain the formation timescale of stellar systems such as the Solar system using deuterium fractionation as a "chemical clock". I determine the physical conditions necessary to reach the observed values of deuterium fraction in pre-stellar cores.

  10. Pasteurization of IgM-enriched Immunoglobulin

    Directory of Open Access Journals (Sweden)

    Kamran Mousavi Hosseini

    2004-06-01

    Full Text Available Human plasma proteins are important for therapy or prophylaxis of human diseases. Due to the preparation of human plasma proteins from human plasma pools and risk of contamination with human viruses, different viral reduction treatments such as: pasteurization, solvent/detergent, dry heat treatment, steam treatment, beta-propiolactone/UV and nanofiltration have been implemented. As pasteurization can be performed for liquid protein, this method (a 10-hour heat treatment of the aqueous solutions at 60°C was introduced into the manufacturing procedure of IgM-enriched immunoglobulin, to improve its safety further. The efficiency of this method for inactivation of viruses was evaluated by the use of Foot-and-Mouth Disease Virus (a non-enveloped virus and Infectious Bovine Rhinotracheitis (IBR Virus (a lipid-enveloped virus. Pasteurization inactivated Foot-and-Mouth Disease Virus by 7 log10 and for IBR Virus by 5log10. These findings show a significant added measure of virus safety associated with pasteurization of IgM-enriched immunoglobulin preparation.

  11. ENRICHMENT OF POULTRY PRODUCTS WITH FUNCTIONAL INGREDIENTS

    Directory of Open Access Journals (Sweden)

    Gordana Kralik

    2012-06-01

    Full Text Available Primary role of food is to provide nutritive stuffs in sufficient amounts to meet nutritive requirements. However, recent scientific findings confirm assumptions that particular food or its ingredients had positive physiological and psychological effects on health. Functional food is referred to food rich in ingredients, having beneficial effects on one or more functions in an organism. By consuming functional food consumers can expect some health benefits. Production of poultry products as functional food is getting more important on foreign markets while portion of such products on domestic food market is insignificant. The aim of this paper is to present possibilities for enrichment of poultry products, such as broiler and turkey meat and chicken eggs, as they can be characterized as functional food. Functional ingredients in poultry products are polyunsaturated fatty acids (LNA, EPA and DHA and antioxidants. Enrichment of poultry products with the stated ingredients that are beneficial for human health is subject of many researches, and only recently have researches been directed towards assessment of market sustainability of such products.

  12. Novel Membranes and Processes for Oxygen Enrichment

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Haiqing

    2011-11-15

    The overall goal of this project is to develop a membrane process that produces air containing 25-35% oxygen, at a cost of $25-40/ton of equivalent pure oxygen (EPO2). Oxygen-enriched air at such a low cost will allow existing air-fueled furnaces to be converted economically to oxygen-enriched furnaces, which in turn will improve the economic and energy efficiency of combustion processes significantly, and reduce the cost of CO{sub 2} capture and sequestration from flue gases throughout the U.S. manufacturing industries. During the 12-month Concept Definition project: We identified a series of perfluoropolymers (PFPs) with promising oxygen/nitrogen separation properties, which were successfully made into thin film composite membranes. The membranes showed oxygen permeance as high as 1,200 gpu and oxygen/nitrogen selectivity of 3.0, and the permeance and selectivity were stable over the time period tested (60 days). We successfully scaled up the production of high-flux PFP-based membranes, using MTR's commercial coaters. Two bench-scale spiral-wound modules with countercurrent designs were made and parametric tests were performed to understand the effect of feed flow rate and pressure, permeate pressure and sweep flow rate on the membrane module separation properties. At various operating conditions that modeled potential industrial operating conditions, the module separation properties were similar to the pure-gas separation properties in the membrane stamps. We also identified and synthesized new polymers [including polymers of intrinsic microporosity (PIMs) and polyimides] with higher oxygen/nitrogen selectivity (3.5-5.0) than the PFPs, and made these polymers into thin film composite membranes. However, these membranes were susceptible to severe aging; pure-gas permeance decreased nearly six-fold within two weeks, making them impractical for industrial applications of oxygen enrichment. We tested the effect of oxygen-enriched air on NO{sub x} emissions

  13. Modeling ranking, time trade-off, and visual analog scale values for EQ-5D health states: a review and comparison of methods.

    Science.gov (United States)

    Craig, Benjamin M; Busschbach, Jan J V; Salomon, Joshua A

    2009-06-01

    There is rising interest in eliciting health state valuations using rankings. Due to their relative simplicity, ordinal measurement methods may offer an attractive practical alternative to cardinal methods, such as time trade-off (TTO) and visual analog scale (VAS). In this article, we explore alternative models for estimating cardinal health state values from rank responses in a unique multicountry database. We highlight an estimation challenge pertaining to health states just below perfect health (the "nonoptimal gap") and propose an analytic solution to ameliorate this problem. Using a standardized protocol developed by the EuroQol Group, rank, VAS, and TTO responses were collected for 43 health states in 8 countries: Slovenia, Argentina, Denmark, Japan, Netherlands, Spain, United Kingdom, and United States, yielding a sample of 179,431 state responses from 11,483 subjects. States were described using the EQ-5D system, which allows for 3 different possible levels on 5 different dimensions of health. We estimated conditional logit and probit regression models for rank responses. The regressions included 17 health state attribute variables reflecting specific levels on each dimension and counts of different levels across dimensions. This flexible specification accommodates previously published valuation models, such as models applied in the United Kingdom and United States. In addition to fitting standard conditional logit and probit models, which assume equal variance across health states (homoscedasticity), we examined a heteroscedastic probit model that assumes no variance for the 2 points anchoring the scale ("optimal health" and "dead") and relaxes the equal-variance assumption for all other states. Rank-based predictions for the 243 unique states defined by the EQ-5D system were compared with predictions from conventional linear models fitted to TTO and VAS responses. By construction, the TTO and VAS models assume no variance around the anchoring states of

  14. Arsenic enrichment in mangroves, and sediments along Karachi coast, Pakistan

    Directory of Open Access Journals (Sweden)

    Rashida Parveen

    2013-08-01

    Full Text Available Objective: To assess the arsenic (As concentration in different parts of mangroves Avicennia marina and sediments in Karachi coastal area i.e. Korangi Creek , Manora, Kakapir and Sandspit. Methods: Sites are identified for sampling owing to their vicinity to industrial activities. Sandspit is targeted for its being devoid of industries. The hydride generation atomic absorption spectrometry (HG-AAS were used to analyse the concentration of arsenic in mangrove and sediment. Results: The high concentration of As was found in roots and middle aerial part as compared to the upper part of mangroves. The concentrations of As was found higher in sediments as compared to the mangroves. There is a seasonal variation of As enrichment in mangrove and sediments as dry seasons showed higher concentration while in rainy season dilution factors may be attributed to the low level of As. The concentration variation of As in sampling sites of mangroves and sediments following the trend i.e. Korangi Creek >Manora>Kakapir>Sandspit. The statistical analysis (Two way ANOVA of data exhibited no significant difference (P>0.05 for trace metals concentrations in mangrove as well as in sediments. Conclusions: It is obvious to conclude that As should be continuously monitored in different environmental segments. The data must correlate with geographical distribution of As, quantification in different species, their solubility and bioavailability to understand the possible factors responsible for environmental pollution. The present study will be helpful to improve water management resources.

  15. The Classical Heritage in America: A Curriculum Resource. Tentative Edition.

    Science.gov (United States)

    Philadelphia School District, PA. Office of Curriculum and Instruction.

    This curriculum resource is intended to help make students of Latin, Greek and other subjects more aware of America's classical heritage. It is designed to be used selectively by teachers to enrich the regular curriculum in classical languages in elementary and secondary schools. In providing background information for the teacher and suggestions…

  16. The librarian's role in an enrichment program for high school students interested in the health professions.

    Science.gov (United States)

    Rossini, Beverly; Burnham, Judy; Wright, Andrea

    2013-01-01

    Librarians from the University of South Alabama Biomedical Library partnered to participate in a program that targets minority students interested in health care with instruction in information literacy. Librarians participate in the summer enrichment programs designed to encourage minority students to enter health care professions by enhancing their preparation. The curriculum developed by the Biomedical Library librarians is focused on developing information searching skills. Students indicated that the library segment helped them in their library research efforts and helped them make more effective use of available resources. Librarians involved report a sense of self-satisfaction as the program allows them to contribute to promoting greater diversity in health care professions. Participating in the summer enrichment program has been beneficial to the students and librarians.

  17. Gravity and Magnetic Anomaly Interpretations and 2.5D Cross-Section Models over the Border Ranges Fault System and Aleutian Subduction Zone, Alaska

    Science.gov (United States)

    Mankhemthong, N.; Doser, D. I.; Baker, M. R.; Kaip, G.; Jones, S.; Eslick, B. E.; Budhathoki, P.

    2011-12-01

    Quaternary glacial covers and lack of dense geophysical data on the Kenai Peninsula cause a location and geometry of the Border Ranges fault system (BRFS) within a recent forearc-accretionary boundary of Aleutian subduction zone in southern Alaska are unclear. Using new ~1,300 gravity collections within the Anchorage and Kenai Peninsula regions complied with prior 1997 gravity and aeromagnetic data help us better imaging these fault and the subduction structures. Cook Inlet forearc basin is corresponded by deep gravity anomaly lows; basin boundaries are characterized by a strong gravity gradient, where are considered to be traces of Border Ranges fault system on the east and Castle Mountain and Bruin Bay fault system on the west and northwest of the forearc basin respectively. Gravity anomaly highs over accreted rocks generally increase southeastward to the Aleutian trench, but show a gravity depression over the Kenai Mountains region. The lineament between gravity high and low in the same terrenes over the Kenai Peninsula is may be another evidence to determine the Southern Edge of the Yakutat Microplate (SEY) as inferred by Eberhart-Phillips et al. (2006). Our 2.5-D models illustrate the main fault of the BRFS dips steeply toward the west with a downslip displacement. Gravity and Magnetic anomaly highs, on the east of the BRFS, probably present a slice of the ultramafic complex emplaced by faults along the boundary of the forearc basin and accretionary wedge terranes. Another magnetic high beneath the basin in the southern forearc basin support a serpentiznied body inferred by Saltus et al. (2001), with a decreasing size toward the north. Regional density-gravity models show the Pacific subducting slab beneath the foreacre-arc teranes with a gentle and flatted dip where the subducting plate is located in north of SEY and dips more steeply where it is located on the south of SEY. The gravity depression over the accreted terrene can be explained by a density low

  18. Seismically Inferred Rupture Process of the 2011 Tohoku-Oki Earthquake by Using Data-Validated 3D and 2.5D Green's Tensor Waveforms

    Science.gov (United States)

    Okamoto, T.; Takenaka, H.; Hara, T.; Nakamura, T.; Aoki, T.

    2014-12-01

    We analyze "seismic" rupture process of the March 11, 2011 Tohoku-Oki earthquake (GCMT Mw9.1) by using a non-linear multi-time-window waveform inversion method. We incorporate the effect of the near-source laterally heterogeneous structure on the synthetic Green's tensor waveforms; otherwise the analysis may result in erroneous solutions [1]. To increase the resolution we use teleseismic and strong-motion seismograms jointly because the one-sided distribution of strong-motion station may cause reduced resolution near the trench axis [2]. We use a 2.5D FDM [3] for teleseismic P-waves and a full 3D FDM that incorporates topography, oceanic water layer, 3D heterogeneity and attenuation for strong-motions [4]. We apply multi-GPU acceleration by using the TSUBAME supercomputer in Tokyo Institute of Technology [5]. We "validated" the Green's tensor waveforms with a point-source moment tensor inversion analysis for a small (Mw5.8) shallow event: we confirm the observed waveforms are reproduced well with the synthetics.The inferred slip distribution using the 2.5D and 3D Green's functions has large slips (max. 37 m) near the hypocenter and small slips near the trench (figure). Also an isolated slip region is identified close to Fukushima prefecture. These features are similar to those obtained by our preliminary study [4]. The land-ward large slips and trench-ward small slips have also been reported by [2]. It is remarkable that we confirmed these features by using data-validated Green's functions. On the other hand very large slips are inferred close to the trench when we apply "1D" Green's functions that do not incorporate the lateral heterogeneity. Our result suggests the trench-ward large deformation that caused large tsunamis did not radiate strong seismic waves. Very slow slips (e.g., the tsunami earthquake), delayed slips and anelastic deformation are among the candidates of the physical processes of the deformation.[1] Okamoto and Takenaka, EPS, 61, e17-e20, 2009

  19. MO-E-17A-02: Incorporation of Contrast Medium Dynamics in Anthropomorphic Phantoms: The Advent of 5D XCAT Models

    Energy Technology Data Exchange (ETDEWEB)

    Sahbaee, P [NC State University, Raleigh, NC (United States); Samei, E [Duke University Medical Center, Durham, NC (United States); Segars, W [Duke University, Durham, NC (United States)

    2014-06-15

    Purpose: To develop a unique method to incorporate the dynamics of contrast-medium propagation into the anthropomorphic phantom, to generate a five-dimensional (5D) patient model for multimodality imaging studies. Methods: A compartmental model of blood circulation network within the body was embodied into an extended cardiac-torso (4D-XCAT) patient model. To do so, a computational physiologic model of the human cardiovascular system was developed which includes a series of compartments representing heart, vessels, and organs. Patient-specific cardiac output and blood volume were used as inputs influenced by the weight, height, age, and gender of the patient's model. For a given injection protocol and given XCAT model, the contrast-medium transmission within the body was described by a series of mass balance differential equations, the solutions to which provided the contrast enhancement-time curves for each organ; thereby defining the tissue materials including the contrastmedium within the XCAT model. A library of time-dependent organ materials was then defined. Each organ in each voxelized 4D-XCAT phantom was assigned to a corresponding time-varying material to create the 5D-XCAT phantom in which the fifth dimension is blood/contrast-medium within the temporal domain. Results: The model effectively predicts the time-varying concentration behavior of various contrast-medium administration in each organ for different patient models as function of patient size (weight/height) and different injection protocol factors (injection rate and pattern, iodine concentration or volume). The contrast enhanced XCAT patient models was developed based on the concentration of iodine as a function of time after injection. Conclusion: Majority of medical imaging systems take advantage of contrast-medium administration in terms of better image quality, the effect of which was ignored in previous optimization studies. The study enables a comprehensive optimization of contrast

  20. Nutrient enrichment and food web composition affect ecosystem metabolism in an experimental seagrass habitat.

    Directory of Open Access Journals (Sweden)

    Amanda C Spivak

    Full Text Available BACKGROUND: Food web composition and resource levels can influence ecosystem properties such as productivity and elemental cycles. In particular, herbivores occupy a central place in food webs as the species richness and composition of this trophic level may simultaneously influence the transmission of resource and predator effects to higher and lower trophic levels, respectively. Yet, these interactions are poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Using an experimental seagrass mesocosm system, we factorially manipulated water column nutrient concentrations, food chain length, and diversity of crustacean grazers to address two questions: (1 Does food web composition modulate the effects of nutrient enrichment on plant and grazer biomasses and stoichiometry? (2 Do ecosystem fluxes of dissolved oxygen and nutrients more closely reflect above-ground biomass and community structure or sediment processes? Nutrient enrichment and grazer presence generally had strong effects on biomass accumulation, stoichiometry, and ecosystem fluxes, whereas predator effects were weaker or absent. Nutrient enrichment had little effect on producer biomass or net ecosystem production but strongly increased seagrass nutrient content, ecosystem flux rates, and grazer secondary production, suggesting that enhanced production was efficiently transferred from producers to herbivores. Gross ecosystem production (oxygen evolution correlated positively with above-ground plant biomass, whereas inorganic nutrient fluxes were unrelated to plant or grazer biomasses, suggesting dominance by sediment microbial processes. Finally, grazer richness significantly stabilized ecosystem processes, as predators decreased ecosystem production and respiration only in the zero- and one- species grazer treatments. CONCLUSIONS/SIGNIFICANCE: Overall, our results indicate that consumer presence and species composition strongly influence ecosystem responses to nutrient enrichment, and

  1. Comparación de las escalas EQ-5D y FACT-G en la evaluación de la calidad de vida en pacientes colombianos con cáncer

    Directory of Open Access Journals (Sweden)

    Juliet Valdelamar Jiménez

    2015-08-01

    Full Text Available Objective: To evaluate patterns of correlations between the different dimensions of a scale measuring quality of life (FACT-G and one that measures perceived health and quality of life (EQ-5D in cancer patients. Methods: A descriptive study that evaluated 114 patients with confirmed cancer of breast (40=35.09%, gastric (26=22.8%, prostate (22=19.3%, colon-rectal (17=14.91%. Diagnosis was made at the National Cancer Institute of Colombia, to whom applied the FACT-G and EQ-5D scale. Descriptive analyses were used to summarize the variables, methods of multivariate analysis, factor analysis and multidimensional scaling were used to assess patterns of correlation between the variables of each of the two scales used. Results: The dimensions that showed acceptable correlation values were physical well-being and emotional well-being of the FACT- G with anxiety and depression of the EQ- 5D scale. Factor analysis yielded two factors: (a anxiety / depression or the EQ-5D is better grouped with the components of the FACT- G, and (b physical symptoms of FACT-G with the components of the EQ-5D. Multidimensional scaling analysis suggested that each scale measured different dimensions of the construct quality of life. Conclusion: The FACT-G is oriented to emotional and social interaction, while the EQ-5D is oriented to aspects of physical and functionality.

  2. P189-T IMAC Enrichment of Phosphopeptides Coupled with 18O Labeling: Quantitative Phosphoproteomics

    Science.gov (United States)

    Turner, J. L.; Walters, J. J.; Heutel, J. D.; Radwanski, B. K.; Boland, J.; Ray, K.; Dapron, J. G.

    2007-01-01

    The up- and down-regulation of protein expression has long been a focus of proteomics researchers and has given rise to several mass spectrometry–based quantitation techniques. In the past decade, a great deal of attention has turned toward the subproteomes, particularly those representing post-translational modifications (PTMs), such as phosphorylation. Those PTMs often play key roles in signaling cascades, and affect a number of cellular processes; their study offers insight into intracellular function. We illustrate here phosphoproteome quantitation through the pairing of immobilized metal-affinity chromatography (IMAC) and 18O labeling, which allows for the determination of modulated phosphorylated species in response to external stressors. Following application of varying biological stressors and isolation of each resultant proteome, the samples were proteolytically cleaved using immobilized trypsin. IMAC enrichment of phosphorylated peptides was accomplished using a nitrilotriacetic acid (NTA) analog bonded to silica, presenting Ga3+ as the chelated metal species. Immobilized trypsin was also employed for incorporation of 18O into the sample for quantitative global labeling. It was determined that IMAC enrichment utilizing this combination of chelate, substrate, and metal provided significant enrichment of phosphopeptides that afforded signal levels, which allowed for quantitative analysis of the phosphoproteome. The use of 18O labeling of the samples permitted a global approach to targeting the phosphoproteome concurrent with the non-phosphorylated component. Using MS analysis before and after IMAC-based phosphopeptide enrichment revealed a distinction in regulation of expression and modulation through phosphorylation of the proteins. The coupling of phosphopeptide enrichment with global isotopic labeling provides a valuable and enabling resource for the vastly under-explored area of quantitative phosphoproteomics.

  3. Design Enriches Life,Life Breeds Fashion

    Directory of Open Access Journals (Sweden)

    Yun Gong

    2016-11-01

    Full Text Available As society advances and technology changes,fashion design has developed from the initial few exclusive to public demand, and fashion category also covers all walks of life, extends to every area from a single demand to industrialization. Fashion design development, has become an indispensable part of people's lives. Fashion satisfies public demand, reflecting the public interest towards, and designer correctly grasp of fashion and taste of popular motivated the design of continuous innovation to creating new business value, cultural values of the social value of fashion. A precise definition to fashion is hard, cause too broad as it relates to areas, such as products, clothing, entertainment, advertising, decoration, home, fashion is reach into every aspect of our lives. Fashion derived from life elements, convergence elements of era and innovation into your life all over again, this cycle forward and updated, fully embodies the understanding of art and life. Design enriches life, life gave birth to fashion.

  4. Food enrichment with marine phospholipid emulsions

    DEFF Research Database (Denmark)

    Lu, Henna Fung Sieng; Nielsen, Nina Skall; Baron, Caroline P.

    Many studies have shown that marine phospholipids (PL) provide more advantages than fish oil. They seem to have better bioavailability, better resistance towards oxidation and higher content of eicosapentaenoic acids and docosahexaenoic acids than fish oil, which essentially contains triglycerides...... to the interaction between lipid oxidation products with amine group either from phosphatidylethanolamine or residues of amino acids/proteins in marine PL. The study on enrichment of yoghurt with marine PL showed that the oxidative stability and sensory acceptability was highly dependent on the quality...... marine PL emulsions with and without addition of fish oil. The oxidative stability of marine PL emulsions was significantly influenced by the chemical composition of marine PL used for emulsions preparation. For instance, emulsions with good oxidative stability could be obtained when using raw materials...

  5. Kennel enrichment: exercise and socialization of dogs.

    Science.gov (United States)

    Coppinger, R; Zuccotti, J

    1999-01-01

    In the last 50 years, there has been a growing need for storage and management systems for the production and maintenance of large numbers of dogs. Unwanted dogs and strays, detained in kennels, stay for various lengths of time. Large kennels also produce dogs for sale as companion animals, for the service dog industry (police and guide dogs), for biomedical research, and for use by dog food companies. Across the United States, literally tens of thousands of dogs are born in kennels and spend their lives in kennels. The laboratory dog, the kennel dog, the service dog, and the companion dog are in an evolutionary transition period, accompanied by concomitant adaptation to stresses signaled by a high frequency of genetic disease and behavioral abnormalities. For kennel enrichment programs, such as socialization and exercise, the modern kenneled dog is a genetically moving target. Specific recommendations apply neither to all breeds nor to the variations within a single breed.

  6. Glycoprotein Enrichment Analytical Techniques: Advantages and Disadvantages.

    Science.gov (United States)

    Zhu, R; Zacharias, L; Wooding, K M; Peng, W; Mechref, Y

    2017-01-01

    Protein glycosylation is one of the most important posttranslational modifications. Numerous biological functions are related to protein glycosylation. However, analytical challenges remain in the glycoprotein analysis. To overcome the challenges associated with glycoprotein analysis, many analytical techniques were developed in recent years. Enrichment methods were used to improve the sensitivity of detection, while HPLC and mass spectrometry methods were developed to facilitate the separation of glycopeptides/proteins and enhance detection, respectively. Fragmentation techniques applied in modern mass spectrometers allow the structural interpretation of glycopeptides/proteins, while automated software tools started replacing manual processing to improve the reliability and throughput of the analysis. In this chapter, the current methodologies of glycoprotein analysis were discussed. Multiple analytical techniques are compared, and advantages and disadvantages of each technique are highlighted. © 2017 Elsevier Inc. All rights reserved.

  7. Response of the brain to enrichment

    Directory of Open Access Journals (Sweden)

    MARIAN C. DIAMOND

    2001-06-01

    Full Text Available Before 1960, the brain was considered by scientists to be immutable, subject only to genetic control. In the early sixties, however, investigators were seriously speculating that environmental influences might be capable of altering brain structure. By 1964, two research laboratories proved that the morphology and chemistry or physiology of the brain could be experientially altered (Bennett et al. 1964, Hubel and Wiesel 1965. Since then, the capacity of the brain to respond to environmental input, specifically "enrichment,'' has become an accepted fact among neuroscientists, educators and others. In fact, the demonstration that environmental enrichment can modify structural components of the rat brain at any age altered prevailing presumptions about the brain's plasticity (Diamond et al. 1964, Diamond 1988. The cerebral cortex, the area associated with higher cognitive processing, is more receptive than other parts of the brain to environmental enrichment. The message is clear: Although the brain possesses a relatively constant macrostructural organization, the ever-changing cerebral cortex, with its complex microarchitecture of unknown potential, is powerfully shaped by experiences before birth, during youth and, in fact, throughout life. It is essential to note that enrichment effects on the brain have consequences on behavior. Parents, educators, policy makers, and individuals can all benefit from such knowledge.Antes de 1960, os cientistas consideravam o encéfalo como imutável, sujeito apenas ao controle genético. Entretanto, no início dos anos 60, alguns pesquisadores especulavam seriamente que influências ambientais podiam ser capazes de alterar a estrutura cerebral. Por volta de 1964, dois laboratórios de pesquisa demonstraram que a morfologia e a química ou a fisiologia do cérebro poderia ser modificada pela experiência (Bennett et al. 1964, Hubel e Wiesel 1965. Desde então, a capacidade do cérebro a responder para responder a

  8. A reading enrichment program for gifted adolescent

    Directory of Open Access Journals (Sweden)

    Silvia Morales Silva

    2008-06-01

    Full Text Available This descriptive research examines the performance on reading comprehension of four gifted adolescents participating in a reading enrichment program. This performance is related to the variables associated to the gifted performance following the model developed by Mönks: motivation, creativity, high ability, school, peers and family. Results showed that school does not satisfy the cognitive needs of these students and it does not offer the required social support either. The family provides the main social support. The motivation, creativity, the high level of language and concentration of the participants facilitate learning. The reading program is described by the participants as motivating due to the subject-matters and methodology; furthermore, due to the opportunity to deal with peers who have a similar cognitive level.

  9. Enriched natural zeolites – mineral fertilizer

    Directory of Open Access Journals (Sweden)

    Rybárová Lucia

    2001-12-01

    Full Text Available Clinoptilolit belongs to the big group of minerals called zeolites. Chemically they are alumosilicates and have a very difficult crystal structure. Nature zeolites are used as sorbents, molecular sieves and catalyzators. Their application is also in agriculture and horticulture. Endeavour of all agricurtural subjects from the plant area is to reach a maximum efficiency and production.Charges for the fertilization are 14 – 40% of all charges depending on the structure of product, intensity of production and share of nutrition in soil. For the elimination of the loss in the nutrition matter, it is possible to use a „porter“, which secures a regular and inteligent supply of nutrition to plants.Regarding the physical and chemical properties is good to use natural zeolites as a „porter“.The experiments were made with enriched zeolites, and their influences an vegetables and flowers roots was reserched. Results were positive.

  10. Thermogenic Effect from Nutritionally Enriched Coffee Consumption

    Directory of Open Access Journals (Sweden)

    Jennings Peter F

    2006-06-01

    Full Text Available Abstract Background The purpose of this study was to examine the effect of nutritionally enriched JavaFit™ (JF coffee (450 mg of caffeine, 1200 mg of garcinia cambogia, 360 mg of citrus aurantium extract, and 225 mcg of chromium polynicotinate on resting oxygen uptake (VO2, respiratory exchange ratio (RER, heart rate (HR, and blood pressure (BP in healthy and physically active individuals. Method Ten subjects (8 male, 2 female; 20.9 ± 1.7 y; 178.1 ± 10.4 cm; 71.8 ± 12.1 kg underwent two testing sessions administered in a randomized and double-blind fashion. During each session, subjects reported to the Human Performance Laboratory after at least 3-h post-absorptive state and were provided either 354 ml (1.5 cups of freshly brewed JF or commercially available caffeinated coffee (P. Subjects then rested in a semi-recumbent position for three hours. VO2 and HR were determined every 5 min during the first 30 min and every 10 min during the next 150 min. BP was determined every 15 min during the first 30 min and every 30 min thereafter. Area under the curve (AUC analysis was computed for VO2, whereas a session-average was calculated for RER, HR and BP. Results Initial analysis revealed no significant differences. However, seven of the ten subjects were considered responders to JF (had a higher AUC for VO2during JF than P. Statistical analysis showed the difference between JF and P (12% to be significantly different in these responders. In addition, the average systolic BP was higher (p Conclusion It appears that consuming a nutritionally-enriched coffee beverage may increase resting energy expenditure in individuals that are sensitive to the caffeine and herbal coffee supplement. In addition, this supplement also appears to affect cardiovascular dynamics by augmenting systolic arterial blood pressure.

  11. Hybrid Enrichment Verification Array: Module Characterization Studies

    Energy Technology Data Exchange (ETDEWEB)

    Zalavadia, Mital A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Smith, Leon E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McDonald, Benjamin S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kulisek, Jonathan A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mace, Emily K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Deshmukh, Nikhil S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-03-01

    The work presented in this report is focused on the characterization and refinement of the Hybrid Enrichment Verification Array (HEVA) approach, which combines the traditional 186-keV 235U signature with high-energy prompt gamma rays from neutron capture in the detector and surrounding collimator material, to determine the relative enrichment and 235U mass of the cylinder. The design of the HEVA modules (hardware and software) deployed in the current field trial builds on over seven years of study and evolution by PNNL, and consists of a ø3''×3'' NaI(Tl) scintillator coupled to an Osprey digital multi-channel analyzer tube base from Canberra. The core of the HEVA methodology, the high-energy prompt gamma-ray signature, serves as an indirect method for the measurement of total neutron emission from the cylinder. A method for measuring the intrinsic efficiency of this “non-traditional” neutron signature and the results from a benchmark experiment are presented. Also discussed are potential perturbing effects on the non-traditional signature, including short-lived activation of materials in the HEVA module. Modeling and empirical results are presented to demonstrate that such effects are expected to be negligible for the envisioned implementation scenario. In comparison to previous versions, the new design boosts the high-energy prompt gamma-ray signature, provides more flexible and effective collimation, and improves count-rate management via commercially available pulse-processing electronics with a special modification prompted by PNNL.

  12. The geological and microbiological controls on the enrichment of Se and Te in sedimentary rocks

    Science.gov (United States)

    Bullock, Liam; Parnell, John; Armstrong, Joseph; Boyce, Adrian; Perez, Magali

    2017-04-01

    sequestered out of seawater into pyritic shales at a higher rate than into crusts. Se enrichment in roll-fronts relates to the initial mobilisation of trace elements in oxidised conditions, and later precipitation downgradient in reduced conditions. Results highlight the potential for sedimentary types of Se- and Te-bearing deposits. The enrichment of elements of high value for future technologies in sedimentary rocks deserve careful assessment for potential future resources, and should be monitored during exploration and mobilisation due to the potential contamination effects. This work forms part of the NERC-funded 'Security of Supply of Mineral Resources' project, which aims to detail the science needed to sustain the security of supply of strategic minerals in a changing environment.

  13. Structure, magnetism and electronic properties in 3d–5d based double perovskite ({Sr_{1-x}} Y x )2FeIrO6

    Science.gov (United States)

    Kharkwal, K. C.; Pramanik, A. K.

    2017-12-01

    The 3d–5d based double perovskites are of current interest as they provide model systems to study the interplay between electronic correlation (U) and spin–orbit coupling (SOC). Here, we report detailed structural, magnetic and transport properties of doped double perovskite material (Sr1-x Y x )2FeIrO6 with x ≤slant 0.2 . With substitution of Y, the system retains its original crystal structure but structural parameters change with x in nonmonotonic fashion. The magnetization data for Sr2FeIrO6 show antiferromagnetic type magnetic transition around 45 K however, a close inspection of the data indicates a weak magnetic phase transition around 120 K. No change of structural symmetry has been observed down to low temperature, although the lattice parameters show sudden changes around the magnetic transitions. Sr2FeIrO6 shows an insulating behavior over the whole temperature range, which nevertheless does not change with Y substitution. The nature of charge conduction is found to follow thermally activated Mott’s variable range hopping and power law behavior for parent and doped samples, respectively. Interestingly, evolution of structural, magnetic and transport behavior in (Sr1-x Y x )2FeIrO6 is observed to reverse with x > 0.1 , which is believed to arise due to a change in the transition metal ionic state.

  14. Magneto-Structural Correlations in [Mn3O]7+ Core SMMs and Selected 4d, 5d and 4f SMMs

    DEFF Research Database (Denmark)

    Sigrist, Marc

    This thesis describes the insight sought and gained for a range of molecule-based magnetic systems with special emphasis on a class of trinuclear manganese(III) complexes. In chapter 2 a series of Mn3 SMMs with different equatorial R-sao2- oximate ligands are studied. The unique structural property...... of these Mn trinuclear complexes is that due to the restrictive ligand surrounding along the JT-axes of the Mn(III) ions, the molecule becomes very rigid and the addition of a bulkier group on the sao2- ligand (from H, over Me and Et to Ph) leads a breaking of the trigonal symmetry. The molecules...... on each Mn center, that both are linked to a central hexacyanidometallates(III) (4d/5d) ion by cyanide bridges. First the molecule containing the diamagnetic Ir(III) was measured using EPR and INS as well as magnetic measurements, to determine the anisotropy on the Mn sites DMn and EMn and to obtain...

  15. First-principles study of site occupancy of 3d, 4d and 5d transition-metal elements in L10TiAl

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Chao [Los Alamos National Laboratory

    2008-01-01

    Using a statistical-mechanical Wagner-Schottky model parametrized by first-principles density-functional (DFT-GGA) calculations on 32-atom supercells, we predict the lattice site occupancy of 3d (Ti-Cu), 4d (Zr-Ag) and 5d (Hf-Au) transition-metal elements in L10 TiAl intermetallic compound as a function of both alloy composition and temperature. The effects of local atomic relaxations, anisotropic lattice distortions, as well as magnetism on point defect energetics are fully taken into account. Our calculations show that, at all alloy compositions and temperatures, Zr and Hf consistently show a preference for the Ti sublattice, while Co, Ru, Rh, Pd, Ag, Re, Os, Ir, Pt and Au consistently show a preference for the Al sublattice. In contrast, the site preference of V, Cr, Mn, Fe, Ni, Cu, Nb, Mo, Tc, Ta and W strongly depend on both alloy stoichiometry and temperature. Our calculated results compare favorably with the existing theoretical and experimental studies in the literature.

  16. Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients--a single-center cohort study.

    Science.gov (United States)

    Iimori, Soichiro; Mori, Yoshihiro; Akita, Wataru; Kuyama, Tamaki; Takada, Shigeru; Asai, Tomoki; Kuwahara, Michio; Sasaki, Sei; Tsukamoto, Yusuke

    2012-01-01

    In chronic kidney disease stage 5D, diagnostic usefulness of bone mineral density (BMD) in predicting fracture has not been established because of variable results in previous studies. The reason for this may be the heterogeneity of underlying pathogenesis of the fracture. BMD was measured annually and serum biochemistry monthly for 485 hemodialyzed patients from April 2003 to March 2008, and all fractures were recorded. Forty-six new episodes of any type of fracture and 29 cases of prevalent spine fracture were recorded. Serum bone-specific alkaline phosphatase (b-AP) was a very useful surrogate marker for any type of incident fracture risk [area under curve (AUC) = 0.766, P fracture was associated with parathyroid hormone (PTH) levels either 300 pg/mL (HR = 5.88, P power for incident of any type of fracture by BMD at the total hip (AUC = 0.760, P power to discriminate prevalent spine fracture regardless of gender or PTH. Hemodialyzed patients with low or high PTH or increased b-AP had a high fracture risk. BMD by Dual Energy X-ray Absorptiometry (DEXA), especially at the total hip region, was useful to predict any type of incident of fracture for females with low PTH or to discriminate prevalent spine fracture for every patient.

  17. Formation of a covalent complex between the 80,000-dalton adenovirus terminal protein and 5'-dCMP in vitro.

    Science.gov (United States)

    Lichy, J H; Horwitz, M S; Hurwitz, J

    1981-05-01

    An in vitro adenovirus DNA replication system catalyzed the formation of a covalent complex between an 80,000-dalton protein and 5'-dCMP in the presence of [alpha-32P-dCTP, MgCl2, ATP, and adenovirus (Ad) DNA with a protein covalently bound to the 5' end of each strand (Ad DNA-prot). The requirement for Ad DNA-prot in this reaction was similar to that for in vitro DNA replication. When dATP, dTTP, and the 2',3'-dideoxynucleoside triphosphate (ddNTP) ddGTP were included in the reaction mixture, an elongated complex was detected, which consisted of an 80,000-dalton protein bound to a 26-base oligonucleotide. Formation of the elongated product, but not of the protein-dCMP complex, was inhibited by ddATP, ddCTP, or ddTTP. The requirements for formation of the protein-dCMP complex, the nature of the linkage between protein and dCMP, the size of the protein, and the existence of elongated forms indicated that the protein associated with the complex was identical to the 80,000-dalton Ad terminal protein found on replicating DNA molecules as described by Challberg et al. [Challberg, M. D., Desiderio, S. V. & Kelly, T. J., Jr. (1980) Proc. Natl. Acad. Sci. USA 77, 5105-5109].

  18. Structure, magnetism and electronic properties in 3d-5d based double perovskite (Sr1-xYx)2FeIrO6.

    Science.gov (United States)

    Kharkwal, Kishor Chandra; Pramanik, Ashim Kumar

    2017-10-17

    The 3$d$-5$d$ based double perovskites are of current interest as they provide model system to study the interplay between electronic correlation ($U$) and spin-orbit coupling (SOC). Here we report detailed structural, magnetic and transport properties of doped double perovskite material (Sr$_{1-x}$Y$_x$)$_2$FeIrO$_6$ with $x$ $\\leq$ 0.2. With substitution of Y, system retains its original crystal structure but structural parameters modify with $x$ in nonmonotonic fashion. The magnetization data for Sr$_2$FeIrO$_6$ show antiferromagnetic type magnetic transition around 45 K, however, a close inspection in data indicates a weak magnetic phase transition around 120 K. No change of structural symmetry has been observed down to low temperature, although the lattice parameters show sudden changes around the magnetic transitions. Sr$_2$FeIrO$_6$ shows an insulating behavior over the whole temperature range which yet does not change with Y substitution. Nature of charge conduction is found to follow thermally activated Mott's variable range hopping and power law behavior for parent and doped samples, respectively. Interestingly, evolution of structural, magnetic and transport behavior in (Sr$_{1-x}$Y$_x$)$_2$FeIrO$_6$ is observed to reverse with $x$ $>$ 0.1 which is believed to arise due to change in transition metal ionic state. © 2017 IOP Publishing Ltd.

  19. Ba3MxTi3 -xO9 (M =Ir , Rh): A family of 5 d /4 d -based diluted quantum spin liquids

    Science.gov (United States)

    Kumar, R.; Sheptyakov, D.; Khuntia, P.; Rolfs, K.; Freeman, P. G.; Rønnow, H. M.; Dey, Tusharkanti; Baenitz, M.; Mahajan, A. V.

    2016-11-01

    We report the structural and magnetic properties of the 4 d (M = Rh) based and 5 d (M = Ir) based systems Ba3MxTi3 -xO9 (nominally x =0.5 , 1). The studied compositions were found to crystallize in a hexagonal structure with the centrosymmetric space group P 63/m m c . The structures comprise of A2O9 polyhedra [with the A site (possibly) statistically occupied by M and Ti] in which pairs of transition metal ions are stacked along the crystallographic c axis. These pairs form triangular bilayers in the a b plane. The magnetic Rh and Ir ions occupy these bilayers, diluted by Ti ions even for x =1 . These bilayers are separated by a triangular layer which is dominantly occupied by Ti ions. From magnetization measurements we infer strong antiferromagnetic couplings for all of the materials but the absence of any spin-freezing or spin-ordering down to 2 K. Further, specific heat measurements down to 0.35 K show no sign of a phase transition for any of the compounds. Based on these thermodynamic measurements we propose the emergence of a quantum spin liquid ground state for Ba3Rh0.5Ti2.5O9 , and Ba3Ir0.5Ti2.5O9 , in addition to the already reported Ba3IrTi2O9 .

  20. 21 CFR 137.260 - Enriched corn meals.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Enriched corn meals. 137.260 Section 137.260 Food... Flours and Related Products § 137.260 Enriched corn meals. (a) Enriched corn meals are the foods, each of which conforms to the definition and standard of identity prescribed for a kind of corn meal by §§ 137...

  1. Environmental enrichment in farm, zoo, companion and experimental animals

    OpenAIRE

    Vučinić Marijana

    2009-01-01

    The paper deals with environmental enrichment for domestic animals at farms, animals in zoos, experimental animals and pet animals. Also, the paper defines and describes different strategies of environmental enrichment. Environmental enrichment is a simple and effective mean of prevention of boredom, behavioral disorders as well as an effective mean of improving animal welfare in farm, zoo, companion and experimental animals. Different items and materials may be used for environmental enrichm...

  2. Egyptians, Maya, Minoans. Learning Works Enrichment Series.

    Science.gov (United States)

    Matthies, Susanna

    The activities in this instructional resource book are designed to be used by gifted 4-8th grade students as independent research guides or in guided or cooperative learning environments. The activities are organized in three sections which focus the ancient civilizations of Egypt, Maya, and Minoa. The activities presented encourage development of…

  3. Enrichment and Preservation of Architectural Knowledge

    DEFF Research Database (Denmark)

    Beetz, Jakob; Blümel, Ina; Dietze, Stefan

    2016-01-01

    with contextual data and vocabularies from external resources using Linked Data (LD) and the recognition relevant features and building components. A special focus of the research reported here lies on strategies and policies for their long term archival, information retrieval based on rich semantic metadata...

  4. A Summary of Actinide Enrichment Technologies and Capability Gaps

    Energy Technology Data Exchange (ETDEWEB)

    Patton, Bradley D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Robinson, Sharon M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-01-01

    The evaluation performed in this study indicates that a new program is needed to efficiently provide a national actinide radioisotope enrichment capability to produce milligram-to-gram quantities of unique materials for user communities. This program should leverage past actinide enrichment, the recent advances in stable isotope enrichment, and assessments of the future requirements to cost effectively develop this capability while establishing an experience base for a new generation of researchers in this vital area. Preliminary evaluations indicate that an electromagnetic isotope separation (EMIS) device would have the capability to meet the future needs of the user community for enriched actinides. The EMIS technology could be potentially coupled with other enrichment technologies, such as irradiation, as pre-enrichment and/or post-enrichment systems to increase the throughput, reduce losses of material, and/or reduce operational costs of the base EMIS system. Past actinide enrichment experience and advances in the EMIS technology applied in stable isotope separations should be leveraged with this new evaluation information to assist in the establishment of a domestic actinide radioisotope enrichment capability.

  5. Evaluating biomarkers for prognostic enrichment of clinical trials.

    Science.gov (United States)

    Kerr, Kathleen F; Roth, Jeremy; Zhu, Kehao; Thiessen-Philbrook, Heather; Meisner, Allison; Wilson, Francis Perry; Coca, Steven; Parikh, Chirag R

    2017-12-01

    A potential use of biomarkers is to assist in prognostic enrichment of clinical trials, where only patients at relatively higher risk for an outcome of interest are eligible for the trial. We investigated methods for evaluating biomarkers for prognostic enrichment. We identified five key considerations when considering a biomarker and a screening threshold for prognostic enrichment: (1) clinical trial sample size, (2) calendar time to enroll the trial, (3) total patient screening costs and the total per-patient trial costs, (4) generalizability of trial results, and (5) ethical evaluation of trial eligibility criteria. Items (1)-(3) are amenable to quantitative analysis. We developed the Biomarker Prognostic Enrichment Tool for evaluating biomarkers for prognostic enrichment at varying levels of screening stringency. We demonstrate that both modestly prognostic and strongly prognostic biomarkers can improve trial metrics using Biomarker Prognostic Enrichment Tool. Biomarker Prognostic Enrichment Tool is available as a webtool at http://prognosticenrichment.com and as a package for the R statistical computing platform. In some clinical settings, even biomarkers with modest prognostic performance can be useful for prognostic enrichment. In addition to the quantitative analysis provided by Biomarker Prognostic Enrichment Tool, investigators must consider the generalizability of trial results and evaluate the ethics of trial eligibility criteria.

  6. Gravimetric enrichment of high lipid and starch accumulating microalgae.

    Science.gov (United States)

    Hassanpour, Morteza; Abbasabadi, Mahsa; Ebrahimi, Sirous; Hosseini, Maryam; Sheikhbaglou, Ahmad

    2015-11-01

    This study presents gravimetric enrichment of mixed culture to screen starch and lipid producing species separately in a sequencing batch reactor. In the enriched starch-producing mixed culture photobioreactor, the starch content at the end of steady state batch became 3.42 times the beginning of depletion. Whereas in the enriched lipid-producing photobioreactor, the lipid content at the end of steady state batch became 3 times the beginning of famine phase. The obtained results revealed that the gravimetric enrichment is a suitable screening method for specific production of storage compounds in none-sterile large-scaled condition. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Enriching a Scientific Grammar with Links to Linguistic Resources: The Taalportaal

    NARCIS (Netherlands)

    van der Wouden, Ton; Bouma, Gosse; van de Camp, Matje; van Koppen, Marjo; Landsbergen, Frank; Odijk, Jan; Odijk, Jan; van Hessen, Arjan

    2017-01-01

    Scientific research within the humanities is different from what it was a few decades ago. For instance, new sources of information, such as digital grammars, lexical databases and large corpora of real-language data offer new opportunities for linguistics. The Taalportaal gram- matical database,

  8. Enriching a Scientific Grammar with Links to Linguistic Resources : The Taalportaal

    NARCIS (Netherlands)

    van der Wouden, Ton; Bouma, Gosse; van de Camp, Matje; Koppen, Marjo van|info:eu-repo/dai/nl/203188934; Landsbergen, Frank; Odijk, Jan|info:eu-repo/dai/nl/082781710

    2017-01-01

    Scientic research within the humanities is dierent from what it was a few decades ago. For instance, new sources of information, such as digital grammars, lexical databases and large corpora of real-language data oer new opportunities for linguistics. The Taalportaal grammatical database, with its

  9. Enriching science, practice, and policy relevant to school psychology around the globe.

    Science.gov (United States)

    Jimerson, Shane R

    2016-03-01

    This editorial provides a brief synthesis of the past, present, and future of School Psychology Quarterly, highlighting important contributions as an international resource to enrich, invigorate, enhance, and advance science, practice, and policy relevant to school psychology around the globe. Information herein highlights (a) the value of high quality and timely reviews, (b) publishing manuscripts that address a breadth of important topics relevant to school psychology, and (c) the structure and contributions of the special topic sections featured in School Psychology Quarterly. (c) 2016 APA, all rights reserved).

  10. Effect of enrichment medium on real-time detection of Salmonella enterica from lettuce and tomato enrichment cultures.

    Science.gov (United States)

    Gorski, Lisa; Liang, Anita S

    2010-06-01

    Three enrichment broths commonly used for detection of Salmonella (buffered peptone water [BPW], tryptic soy broth [TSB], and universal preenrichment broth [UPB]) were compared for use in real-time SYBR Green PCR detection of Salmonella introduced into enrichment cultures made from store-bought lettuce and tomatoes. The produce served as a source of normal plant microbiota to measure how well DNA-based detection methods for Salmonella work in a suspension of plant-associated bacteria that may be closely related to Salmonella. A qualitative assessment of the background microbiota that grew in the three enrichment broths cultures from tomato and lettuce samples revealed that different bacteria predominated in the different broths. Results obtained with five produce-related outbreak Salmonella strains and PCR primers directed toward three different Salmonella genes suggest that the ability to detect Salmonella from these enrichment cultures by real-time PCR was 10 to 1,000 times better with TSB enrichment cultures. Detection levels were similar between the different enrichment media when an immunomagnetic separation method was used; however, the immunological technique did not enhance detection from TSB enrichment cultures. Detection could be affected by the medium and by the background microbiota. An immunomagnetic separation method may be useful in BPW and UPB enrichment cultures but not in TSB enrichment cultures.

  11. QALY weights for diabetic retinopathy--a comparison of health state valuations with HUI-3, EQ-5D, EQ-VAS, and TTO.

    Science.gov (United States)

    Heintz, Emelie; Wiréhn, Ann-Britt; Peebo, Beatrice Bourghardt; Rosenqvist, Ulf; Levin, Lars-Åke

    2012-05-01

    To estimate quality-adjusted life-year weights for patients with diabetic retinopathy by using various methods and to investigate the empirical validity of the different measures. The study population comprised 152 patients with diabetes in Östergötland County, Sweden. Participants were interviewed by telephone by using the time trade-off (TTO) method and a visual analogue scale (EQ-VAS) (direct valuations) as well as the EuroQol five-dimensional questionnaire (EQ-5D) and the health utilities index mark 3 (HUI-3) (indirect valuations). The quality-adjusted life-year weights were adjusted for potential confounders by using analysis of covariance. The empirical validity of the measures was examined by testing their ability to detect hypothetical differences between severity levels of diabetic retinopathy and by investigating the correlation between the measures and the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). All measures detected significant differences in scores between patient groups classified according to visual impairment in the better eye (analysis of covariance, P VAS detected significant differences between patient groups classified according to visual impairment or pathological progression in the worse eye. HUI-3 recorded a difference of 0.43 in values between normal vision and blindness in the better eye, which was more than twice the differences captured by the other measures (0.15-0.20). In addition, HUI-3 showed the highest correlation with NEI VFQ-25 (r = 0.54; P < 0.001). In cost-utility analyses, the choice of quality-adjusted life-year measure may affect whether an intervention is considered cost-effective. Furthermore, if decisions are to be based on values from the general public, HUI-3 can be recommended for cost-utility analyses of interventions directed at diabetic retinopathy. Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights

  12. Skipping of exon 30 in C5 gene results in complete human C5 deficiency and demonstrates the importance of C5d and CUB domains for stability.

    Science.gov (United States)

    Aguilar-Ramirez, P; Reis, E S; Florido, M P C; Barbosa, A S; Farah, C S; Costa-Carvalho, B T; Isaac, L

    2009-06-01

    The deficiency of complement C5 is rare and frequently associated with severe and recurrent infections, especially caused by Neisseria spp. We observed the absence of component C5 in the serum of 3 siblings from a Brazilian family with history of consanguinity. The patients had suffered from recurrent episodes of meningitis and other less severe infections. Sera from these patients were unable to mediate hemolytic activity either by the classical or alternative pathways and presented extremely low levels of C5 protein (1.3, 0.9 and 1.0 microg/ml-normal range: 45-190 microg/ml). Hemolytic activity could be restored by the addition of purified C5 to deficient serum. Sequencing of sibling C5 cDNA revealed a homozygous 153 bp deletion that corresponds precisely to exon 30. The parents carried the same deletion but only in one allele. Sequencing of the corresponding region in the genomic DNA revealed a C to G substitution within intron 30 and, most significantly, the substitution of GAG(4028) for GAA(4028) at the 3' end of exon 30 which is most likely responsible for skipping of exon 30. The resulting in-frame deletion in the C5 mRNA codes for a mutant C5 protein lacking residues 1289-1339. These residues map to the CUB and C5d domains of the C5 alpha chain. This deletion is expected to produce a non-functional and unstable C5 protein which is more susceptible to degradation.

  13. Autoradiographic localization of delta opioid receptors within the mesocorticolimbic dopamine system using radioiodinated (2-D-penicillamine, 5-D-penicillamine)enkephalin ( sup 125 I-DPDPE)

    Energy Technology Data Exchange (ETDEWEB)

    Dilts, R.P.; Kalivas, P.W. (Washington State Univ., Pullman (USA))

    1990-01-01

    The enkephalin analog (2-D-penicillamine, 5-D-penicillamine)enkephalin was radioiodinated (125I-DPDPE) and shown to retain a pharmacological selectivity characteristic of the delta opioid receptor in in vitro binding studies. The distributions of 125I-DPDPE binding, using in vitro autoradiographic techniques, were similar to those previously reported for the delta opioid receptor. The nucleus accumbens, striatum, and medial prefrontal cortex contain dense gradients of 125I-DPDPE binding in regions known to receive dopaminergic afferents emanating from the mesencephalic tegmentum. Selective chemical lesions of the ventral tegmental area and substantia nigra were employed to deduce the location of the 125I-DPDPE binding within particular regions of the mesocorticolimbic dopamine system. Unilateral lesions of dopamine perikarya (A9 and A10) within the ventral tegmental area and substantia nigra produced by mesencephalic injection of 6-hydroxydopamine resulted in significant (20-30%) increases in 125I-DPDPE binding contralateral to the lesion within the striatum and nucleus accumbens. Lesions of the perikarya (dopaminergic and nondopaminergic) of the ventral tegmental area, induced by quinolinic acid injections, caused increases of less magnitude within these same nuclei. No significant alterations in 125I-DPDPE binding were observed within the mesencephalon as a result of either treatment. The specificity of the lesions was confirmed by immunocytochemistry for tyrosine hydroxylase. These results suggest that the enkephalins and opioid agonists acting through delta opioid receptors do not directly modulate dopaminergic afferents but do regulate postsynaptic targets of the mesocorticolimbic dopamine system.

  14. Developing selenium-enriched animal feed and biofuel from canola planted for managing Se-laden drainage waters in the westside of central California.

    Science.gov (United States)

    Bañuelos, G S; Da Roche, J; Robinson, J

    2010-03-01

    We studied the reuse of selenium (Se)-laden effluent for producing canola (Brassica napus) and subsequent bioproducts in central California. Canola was irrigated with poor quality waters [electrical conductivity (EC) of approximately 5 dS m(-1) sulfate-salinity, 5 mg B L(-1), and 0.25 mg Se L(-1)]. Typical seed yields were 2.2 metric tons ha(-1). Seeds were processed for their oil, and transesterified to produce ASTM-quality biodiesel (BD) blends. The resulting Se-enriched seed cake meal (containing approximately 2 mg Se kg(-1) DM) was used in a dairy feed trial. Seventy-two Jersey and Holstein cows, 36 respectively, were fed Se-enriched canola meal as 6.2% of their daily feed ration for five weeks. Blood and milk samples were collected weekly and analyzed for total Se. This study showed that Se-enriched canola meal did not significantly increase total blood Se content in either cow breed. Milk Se concentrations did, however, significantly increase to safe levels of 59 microg Se L(-1) and 52 microg Se L(-1) in Jersey and Holstein cows, respectively. The production of BD 20 biofuels and Se-enriched feed meal from canola irrigated with poor quality waters may help sustain similar phytomanagement strategies under Se-rich conditions.

  15. Lunar material resources: An overview

    Science.gov (United States)

    Carter, James L.

    1992-01-01

    The analysis of returned lunar samples and a comparison of the physical and chemical processes operating on the Moon and on the Earth provide a basis for predicting both the possible types of material resources (especially minerals and rocks) and the physical characteristics of ore deposits potentially available on the Moon. The lack of free water on the Moon eliminates the classes of ore deposits that are most exploitable on Earth; namely, (1) hydrothermal, (2) secondary mobilization and enrichment, (3) precipitation from a body of water, and (4) placer. The types of lunar materials available for exploitation are whole rocks and their contained minerals, regolith, fumarolic and vapor deposits, and nonlunar materials, including solar wind implantations. Early exploitation of lunar material resources will be primarily the use of regolith materials for bulk shielding; the extraction from regolith fines of igneous minerals such as plagioclase feldspars and ilmenite for the production of oxygen, structural metals, and water; and possibly the separation from regolith fines of solar-wind-implanted volatiles. The only element, compound, or mineral, that by itself has been identified as having the economic potential for mining, processing, and return to Earth is helium-3.

  16. The Effect of Cyanobacterial Biomass Enrichment by Centrifugation and GF/C Filtration on Subsequent Microcystin Measurement

    Directory of Open Access Journals (Sweden)

    Shelley Rogers

    2015-03-01

    Full Text Available Microcystins are cyclic peptides produced by multiple cyanobacterial genera. After accumulation in the liver of animals they inhibit eukaryotic serine/threonine protein phosphatases, causing liver disease or death. Accurate detection/quantification of microcystins is essential to ensure safe water resources and to enable research on this toxin. Previous methodological comparisons have focused on detection and extraction techniques, but have not investigated the commonly used biomass enrichment steps. These enrichment steps could modulate toxin production as recent studies have demonstrated that high cyanobacterial cell densities cause increased microcystin levels. In this study, three microcystin-producing strains were processed using no cell enrichment steps (by direct freezing at three temperatures and with biomass enrichment (by centrifugation or GF/C filtration. After extraction, microcystins were analyzed using liquid chromatography-tandem mass spectrometry. All processing methods tested, except GF/C filtration, resulted in comparable microcystin quotas for all strains. The low yields observed for the filtration samples were caused by adsorption of arginine-containing microcystins to the GF/C filters. Whilst biomass enrichment did not affect microcystin metabolism over the time-frame of normal sample processing, problems associated with GF/C filtration were identified. The most widely applicable processing method was direct freezing of samples as it could be utilized in both field and laboratory environments.

  17. Towards Information Enrichment through Recommendation Sharing

    Science.gov (United States)

    Weng, Li-Tung; Xu, Yue; Li, Yuefeng; Nayak, Richi

    Nowadays most existing recommender systems operate in a single organisational basis, i.e. a recommender system recommends items to customers of one organisation based on the organisation's datasets only. Very often the datasets of a single organisation do not have sufficient resources to be used to generate quality recommendations. Therefore, it would be beneficial if recommender systems of different organisations with similar nature can cooperate together to share their resources and recommendations. In this chapter, we present an Ecommerce-oriented Distributed Recommender System (EDRS) that consists of multiple recommender systems from different organisations. By sharing resources and recommendations with each other, these recommenders in the distributed recommendation system can provide better recommendation service to their users. As for most of the distributed systems, peer selection is often an important aspect. This chapter also presents a recommender selection technique for the proposed EDRS, and it selects and profiles recommenders based on their stability, average performance and selection frequency. Based on our experiments, it is shown that recommenders' recommendation quality can be effectively improved by adopting the proposed EDRS and the associated peer selection technique.

  18. Enriched axial anomaly in Weyl materials

    Science.gov (United States)

    Raines, Zachary M.; Galitski, Victor M.

    2017-10-01

    While quantum anomalies are often associated with the breaking of a classical symmetry in the quantum theory, their anomalous contributions to observables remain distinct and well defined even when the symmetry is broken from the outset. This paper explores such anomalous contributions to the current, originating from the axial anomaly in a Weyl semimetal, and in the presence of a generic Weyl node-mixing term. We find that apart from the familiar anomalous divergence of the axial current proportional to a product of electric and magnetic fields, there is another anomalous term proportional to a product of the electric field and the orientation of a spin-dependent node-mixing vector. We obtain this result both by a quantum field-theoretic analysis of an effective Weyl action and solving an explicit lattice model. The extended spin-mixing mass terms, and the enriched axial anomaly they entail, could arise as mean-field or proximity-induced order parameters in spin-density-wave phases in Weyl semimetals or be generated dynamically within a Floquet theory.