Contributions in compression of 3D medical images and 2D images; Contributions en compression d'images medicales 3D et d'images naturelles 2D

Energy Technology Data Exchange (ETDEWEB)

Gaudeau, Y

2006-12-15

The huge amounts of volumetric data generated by current medical imaging techniques in the context of an increasing demand for long term archiving solutions, as well as the rapid development of distant radiology make the use of compression inevitable. Indeed, if the medical community has sided until now with compression without losses, most of applications suffer from compression ratios which are too low with this kind of compression. In this context, compression with acceptable losses could be the most appropriate answer. So, we propose a new loss coding scheme based on 3D (3 dimensional) Wavelet Transform and Dead Zone Lattice Vector Quantization 3D (DZLVQ) for medical images. Our algorithm has been evaluated on several computerized tomography (CT) and magnetic resonance image volumes. The main contribution of this work is the design of a multidimensional dead zone which enables to take into account correlations between neighbouring elementary volumes. At high compression ratios, we show that it can out-perform visually and numerically the best existing methods. These promising results are confirmed on head CT by two medical patricians. The second contribution of this document assesses the effect with-loss image compression on CAD (Computer-Aided Decision) detection performance of solid lung nodules. This work on 120 significant lungs images shows that detection did not suffer until 48:1 compression and still was robust at 96:1. The last contribution consists in the complexity reduction of our compression scheme. The first allocation dedicated to 2D DZLVQ uses an exponential of the rate-distortion (R-D) functions. The second allocation for 2D and 3D medical images is based on block statistical model to estimate the R-D curves. These R-D models are based on the joint distribution of wavelet vectors using a multidimensional mixture of generalized Gaussian (MMGG) densities. (author)

MCNP simulations of a new time-resolved Compton scattering imaging technique

International Nuclear Information System (INIS)

Ilan, Y.

2004-01-01

Medical images of human tissue can be produced using Computed Tomography (CT), Positron Emission Tomography (PET), Ultrasound or Magnetic Resonance Imaging (MRI). In all of the above techniques, in order to get a three-dimensional (3D) image, one has to rotate or move the source, the detectors or the scanned target. This procedure is complicated, time consuming and increases the cost and weight of the scanning equipment. Time resolved optical tomography has been suggested as an alternative to the above conventional methods. This technique implies near infrared light (NIR) and fast time-resolved detectors to obtain a 3D image of the scanned target. However, due to the limited penetration of the NIR light in the tissue, the application of this technique is limited to soft tissue like a female breast or a premature infant brain

Image-based RSA: Roentgen stereophotogrammetric analysis based on 2D-3D image registration.

Science.gov (United States)

de Bruin, P W; Kaptein, B L; Stoel, B C; Reiber, J H C; Rozing, P M; Valstar, E R

2008-01-01

Image-based Roentgen stereophotogrammetric analysis (IBRSA) integrates 2D-3D image registration and conventional RSA. Instead of radiopaque RSA bone markers, IBRSA uses 3D CT data, from which digitally reconstructed radiographs (DRRs) are generated. Using 2D-3D image registration, the 3D pose of the CT is iteratively adjusted such that the generated DRRs resemble the 2D RSA images as closely as possible, according to an image matching metric. Effectively, by registering all 2D follow-up moments to the same 3D CT, the CT volume functions as common ground. In two experiments, using RSA and using a micromanipulator as gold standard, IBRSA has been validated on cadaveric and sawbone scapula radiographs, and good matching results have been achieved. The accuracy was: |mu |RSA but higher than in vivo standard RSA. Because IBRSA does not require radiopaque markers, it adds functionality to the RSA method by opening new directions and possibilities for research, such as dynamic analyses using fluoroscopy on subjects without markers and computer navigation applications.

Preclinical, fluorescence and diffuse optical tomography: non-contact instrumentation, modeling and time-resolved 3D reconstruction

International Nuclear Information System (INIS)

Nouizi, F.

2011-09-01

Time-Resolved Diffuse Optical Tomography (TR-DOT) is a new non-invasive imaging technique increasingly used in the clinical and preclinical fields. It yields optical absorption and scattering maps of the explored organs, and related physiological parameters. Time-Resolved Fluorescence Diffuse Optical Tomography (TR-FDOT) is based on the detection of fluorescence photons. It provides spatio-temporal maps of fluorescent probe concentrations and life times, and allows access to metabolic and molecular imaging which is important for diagnosis and therapeutic monitoring, particularly in oncology. The main goal of this thesis was to reconstruct 3D TR-DOT/TR-FDOT images of small animals using time-resolved optical technology. Data were acquired using optical fibers fixed around the animal without contact with its surface. The work was achieved in four steps: 1)- Setting up an imaging device to record the 3D coordinates of an animal's surface; 2)- Modeling the no-contact approach to solve the forward problem; 3)- Processing of the measured signals taking into account the impulse response of the device; 4)- Implementation of a new image reconstruction method based on a selection of carefully chosen points. As a result, good-quality 3D optical images were obtained owing to reduced cross-talk between absorption and scattering. Moreover, the computation time was cut down, compared to full-time methods using whole temporal profiles. (author)

Resolving power test of 2-D K+ K+ interferometry

International Nuclear Information System (INIS)

Padula, Sandra S.; Roldao, Christiane G.

1999-01-01

Adopting a procedure previously proposed to quantitatively study pion interferometry 1 , an equivalent 2-D X 2 analysis was performed to test the resolving power of that method when applied to less favorable conditions, when no significant contribution from long lived resonances is expected, as in kaon interferometry. For that purpose, use is made of the preliminary E859 K + K + interferometry data from Si+Au collisions at 14.6 A GeV/c. Less sensitivity is achieved in the present case, although it is shown that it is still possible to distinguish two distinct decoupling geometries. (author)

Depth resolved hyperspectral imaging spectrometer based on structured light illumination and Fourier transform interferometry

Science.gov (United States)

Choi, Heejin; Wadduwage, Dushan; Matsudaira, Paul T.; So, Peter T.C.

2014-01-01

A depth resolved hyperspectral imaging spectrometer can provide depth resolved imaging both in the spatial and the spectral domain. Images acquired through a standard imaging Fourier transform spectrometer do not have the depth-resolution. By post processing the spectral cubes (x, y, λ) obtained through a Sagnac interferometer under uniform illumination and structured illumination, spectrally resolved images with depth resolution can be recovered using structured light illumination algorithms such as the HiLo method. The proposed scheme is validated with in vitro specimens including fluorescent solution and fluorescent beads with known spectra. The system is further demonstrated in quantifying spectra from 3D resolved features in biological specimens. The system has demonstrated depth resolution of 1.8 μm and spectral resolution of 7 nm respectively. PMID:25360367

Real-time 2D/3D registration using kV-MV image pairs for tumor motion tracking in image guided radiotherapy.

Science.gov (United States)

Furtado, Hugo; Steiner, Elisabeth; Stock, Markus; Georg, Dietmar; Birkfellner, Wolfgang

2013-10-01

Intra-fractional respiratory motion during radiotherapy leads to a larger planning target volume (PTV). Real-time tumor motion tracking by two-dimensional (2D)/3D registration using on-board kilo-voltage (kV) imaging can allow for a reduction of the PTV though motion along the imaging beam axis cannot be resolved using only one projection image. We present a retrospective patient study investigating the impact of paired portal mega-voltage (MV) and kV images on registration accuracy. Material and methods. We used data from 10 patients suffering from non-small cell lung cancer (NSCLC) undergoing stereotactic body radiation therapy (SBRT) lung treatment. For each patient we acquired a planning computed tomography (CT) and sequences of kV and MV images during treatment. We compared the accuracy of motion tracking in six degrees-of-freedom (DOF) using the anterior-posterior (AP) kV sequence or the sequence of kV-MV image pairs. Results. Motion along cranial-caudal direction could accurately be extracted when using only the kV sequence but in AP direction we obtained large errors. When using kV-MV pairs, the average error was reduced from 2.9 mm to 1.5 mm and the motion along AP was successfully extracted. Mean registration time was 188 ms. Conclusion. Our evaluation shows that using kV-MV image pairs leads to improved motion extraction in six DOF and is suitable for real-time tumor motion tracking with a conventional LINAC.

Knowledge Extraction from Atomically Resolved Images.

Science.gov (United States)

Vlcek, Lukas; Maksov, Artem; Pan, Minghu; Vasudevan, Rama K; Kalinin, Sergei V

2017-10-24

Tremendous strides in experimental capabilities of scanning transmission electron microscopy and scanning tunneling microscopy (STM) over the past 30 years made atomically resolved imaging routine. However, consistent integration and use of atomically resolved data with generative models is unavailable, so information on local thermodynamics and other microscopic driving forces encoded in the observed atomic configurations remains hidden. Here, we present a framework based on statistical distance minimization to consistently utilize the information available from atomic configurations obtained from an atomically resolved image and extract meaningful physical interaction parameters. We illustrate the applicability of the framework on an STM image of a FeSe x Te 1-x superconductor, with the segregation of the chalcogen atoms investigated using a nonideal interacting solid solution model. This universal method makes full use of the microscopic degrees of freedom sampled in an atomically resolved image and can be extended via Bayesian inference toward unbiased model selection with uncertainty quantification.

Time-resolved computed tomography of the liver: retrospective, multi-phase image reconstruction derived from volumetric perfusion imaging

Energy Technology Data Exchange (ETDEWEB)

Fischer, Michael A.; Kartalis, Nikolaos; Aspelin, Peter; Albiin, Nils; Brismar, Torkel B. [Karolinska University Hospital, Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm (Sweden); Leidner, Bertil; Svensson, Anders [Karolinska University Hospital, Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm (Sweden); Karolinska University Hospital Huddinge, Department of Radiology, Stockholm (Sweden)

2014-01-15

To assess feasibility and image quality (IQ) of a new post-processing algorithm for retrospective extraction of an optimised multi-phase CT (time-resolved CT) of the liver from volumetric perfusion imaging. Sixteen patients underwent clinically indicated perfusion CT using 4D spiral mode of dual-source 128-slice CT. Three image sets were reconstructed: motion-corrected and noise-reduced (MCNR) images derived from 4D raw data; maximum and average intensity projections (time MIP/AVG) of the arterial/portal/portal-venous phases and all phases (total MIP/ AVG) derived from retrospective fusion of dedicated MCNR split series. Two readers assessed the IQ, detection rate and evaluation time; one reader assessed image noise and lesion-to-liver contrast. Time-resolved CT was feasible in all patients. Each post-processing step yielded a significant reduction of image noise and evaluation time, maintaining lesion-to-liver contrast. Time MIPs/AVGs showed the highest overall IQ without relevant motion artefacts and best depiction of arterial and portal/portal-venous phases respectively. Time MIPs demonstrated a significantly higher detection rate for arterialised liver lesions than total MIPs/AVGs and the raw data series. Time-resolved CT allows data from volumetric perfusion imaging to be condensed into an optimised multi-phase liver CT, yielding a superior IQ and higher detection rate for arterialised liver lesions than the raw data series. (orig.)

The Usefulness of Readout-Segmented Echo-Planar Imaging (RESOLVE) for Bio-phantom Imaging Using 3-Tesla Clinical MRI.

Science.gov (United States)

Yoshimura, Yuuki; Kuroda, Masahiro; Sugiantoc, Irfan; Bamgbosec, Babatunde O; Miyahara, Kanae; Ohmura, Yuichi; Kurozumi, Akira; Matsushita, Toshi; Ohno, Seiichiro; Kanazawa, Susumu; Asaumi, Junichi

2018-02-01

Readout-segmented echo-planar imaging (RESOLVE) is a multi-shot echo-planar imaging (EPI) modality with k-space segmented in the readout direction. We investigated whether RESOLVE decreases the distortion and artifact in the phase direction and increases the signal-to-noise ratio (SNR) in phantoms image taken with 3-tesla (3T) MRI versus conventional EPI. We used a physiological saline phantom and subtraction mapping and observed that RESOLVE's SNR was higher than EPI's. Using RESOLVE, the combination of a special-purpose coil and a large-loop coil had a higher SNR compared to using only a head/neck coil. RESOLVE's image distortioas less than EPI's. We used a 120 mM polyethylene glycol phantom to examine the phase direction artifact.vThe range where the artifact appeared in the apparent diffusion coefficient (ADC) image was shorter with RESOLVE compared to EPI. We used RESOLVE to take images of a Jurkat cell bio-phantom: the cell-region ADC was 856×10-6mm2/sec and the surrounding physiological saline-region ADC was 2,951×10-6mm2/sec. The combination of RESOLVE and the 3T clinical MRI device reduced image distortion and improved SNR and the identification of accurate ADC values due to the phase direction artifact reduction. This combination is useful for obtaining accurate ADC values of bio-phantoms.

2D-3D image registration in diagnostic and interventional X-Ray imaging

NARCIS (Netherlands)

Bom, I.M.J. van der

2010-01-01

Clinical procedures that are conventionally guided by 2D x-ray imaging, may benefit from the additional spatial information provided by 3D image data. For instance, guidance of minimally invasive procedures with CT or MRI data provides 3D spatial information and visualization of structures that are

Holographic method for site-resolved detection of a 2D array of ultracold atoms

Science.gov (United States)

Hoffmann, Daniel Kai; Deissler, Benjamin; Limmer, Wolfgang; Hecker Denschlag, Johannes

2016-08-01

We propose a novel approach to site-resolved detection of a 2D gas of ultracold atoms in an optical lattice. A near-resonant laser beam is coherently scattered by the atomic array, and after passing a lens its interference pattern is holographically recorded by superimposing it with a reference laser beam on a CCD chip. Fourier transformation of the recorded intensity pattern reconstructs the atomic distribution in the lattice with single-site resolution. The holographic detection method requires only about two hundred scattered photons per atom in order to achieve a high reconstruction fidelity of 99.9 %. Therefore, additional cooling during detection might not be necessary even for light atomic elements such as lithium. Furthermore, first investigations suggest that small aberrations of the lens can be post-corrected in imaging processing.

Using Integrated 2D and 3D Resistivity Imaging Methods for Illustrating the Mud-Fluid Conduits of the Wushanting Mud Volcanoes in Southwestern Taiwan

Directory of Open Access Journals (Sweden)

Ping-Yu Chang

2011-01-01

Full Text Available We conducted 2D and 3D looped resistivity surveys in the Wushanting Natural Landscape Preservation Area (WNLPA in order to understand the relationships of the mud-fluid conduits in the mud volcano system. 2D resistivity surveys were conducted along seven networked lines. Two separate C-shape looped electrode arrays surrounding the volcano craters were used in the study. First, the two 3D looped measurements were inverted separately. Yet the inverted 3D images of the mud-volcano system were inconsistent with the landscape features suggesting that artifacts perhaps appeared in the images. The 3D looped data were then combined with the 2D data for creating a global resistivity model of WNLPA. The resulting 3D image is consistent with the observed landscape features. With the resistivity model of WNLPA, we further tried to estimate the distribution of water content. The results suggest that the 3D resistivity image has the potential to resolve the dual porosity structures in the mudstone area. Last, we used a simplified WNLPA model for forward simulation in order to verify the field measurement results. We have concluded that the artifacts in the 3D looped images are in fact shadow effects from conductive objects out of the electrode loops, and that inverted images of combined 2D and 3D data provide detailed regional conductive structures in the WNLPA site.

Rainbow Particle Imaging Velocimetry for Dense 3D Fluid Velocity Imaging

KAUST Repository

Xiong, Jinhui

2017-04-11

Despite significant recent progress, dense, time-resolved imaging of complex, non-stationary 3D flow velocities remains an elusive goal. In this work we tackle this problem by extending an established 2D method, Particle Imaging Velocimetry, to three dimensions by encoding depth into color. The encoding is achieved by illuminating the flow volume with a continuum of light planes (a “rainbow”), such that each depth corresponds to a specific wavelength of light. A diffractive component in the camera optics ensures that all planes are in focus simultaneously. For reconstruction, we derive an image formation model for recovering stationary 3D particle positions. 3D velocity estimation is achieved with a variant of 3D optical flow that accounts for both physical constraints as well as the rainbow image formation model. We evaluate our method with both simulations and an experimental prototype setup.

Contributions in compression of 3D medical images and 2D images

International Nuclear Information System (INIS)

Gaudeau, Y.

2006-12-01

The huge amounts of volumetric data generated by current medical imaging techniques in the context of an increasing demand for long term archiving solutions, as well as the rapid development of distant radiology make the use of compression inevitable. Indeed, if the medical community has sided until now with compression without losses, most of applications suffer from compression ratios which are too low with this kind of compression. In this context, compression with acceptable losses could be the most appropriate answer. So, we propose a new loss coding scheme based on 3D (3 dimensional) Wavelet Transform and Dead Zone Lattice Vector Quantization 3D (DZLVQ) for medical images. Our algorithm has been evaluated on several computerized tomography (CT) and magnetic resonance image volumes. The main contribution of this work is the design of a multidimensional dead zone which enables to take into account correlations between neighbouring elementary volumes. At high compression ratios, we show that it can out-perform visually and numerically the best existing methods. These promising results are confirmed on head CT by two medical patricians. The second contribution of this document assesses the effect with-loss image compression on CAD (Computer-Aided Decision) detection performance of solid lung nodules. This work on 120 significant lungs images shows that detection did not suffer until 48:1 compression and still was robust at 96:1. The last contribution consists in the complexity reduction of our compression scheme. The first allocation dedicated to 2D DZLVQ uses an exponential of the rate-distortion (R-D) functions. The second allocation for 2D and 3D medical images is based on block statistical model to estimate the R-D curves. These R-D models are based on the joint distribution of wavelet vectors using a multidimensional mixture of generalized Gaussian (MMGG) densities. (author)

Automatic Contour Extraction from 2D Image

Directory of Open Access Journals (Sweden)

Panagiotis GIOANNIS

2011-03-01

Full Text Available Aim: To develop a method for automatic contour extraction from a 2D image. Material and Method: The method is divided in two basic parts where the user initially chooses the starting point and the threshold. Finally the method is applied to computed tomography of bone images. Results: An interesting method is developed which can lead to a successful boundary extraction of 2D images. Specifically data extracted from a computed tomography images can be used for 2D bone reconstruction. Conclusions: We believe that such an algorithm or part of it can be applied on several other applications for shape feature extraction in medical image analysis and generally at computer graphics.

Fast, free-breathing, in vivo fetal imaging using time-resolved 3D MRI technique: preliminary results

OpenAIRE

Liu, Jing; Glenn, Orit A.; Xu, Duan

2014-01-01

Fetal MR imaging is very challenging due to the movement of fetus and the breathing motion of the mother. Current clinical protocols involve quick 2D scouting scans to determine scan plane and often several attempts to reorient the scan plane when the fetus moves. This makes acquisition of fetal MR images clinically challenging and results in long scan times in order to obtain images that are of diagnostic quality. Compared to 2D imaging, 3D imaging of the fetus has many advantages such as hi...

Imaging the motion of electrons in 2D semiconductor heterostructures

Science.gov (United States)

Dani, Keshav

Technological progress since the late 20th century has centered on semiconductor devices, such as transistors, diodes, and solar cells. At the heart of these devices, is the internal motion of electrons through semiconductor materials due to applied electric fields or by the excitation of photocarriers. Imaging the motion of these electrons would provide unprecedented insight into this important phenomenon, but requires high spatial and temporal resolution. Current studies of electron dynamics in semiconductors are generally limited by the spatial resolution of optical probes, or by the temporal resolution of electronic probes. In this talk, we combine femtosecond pump-probe techniques with spectroscopic photoemission electron microscopy to image the motion of photoexcited electrons from high-energy to low-energy states in a 2D InSe/GaAs heterostructure exhibiting a type-II band alignment. At the instant of photoexcitation, energy-resolved photoelectron images reveal a highly non-equilibrium distribution of photocarriers in space and energy. Thereafter, in response to the out-of-equilibrium photocarriers, we observe the spatial redistribution of charges, thus forming internal electric fields, bending the semiconductor bands, and finally impeding further charge transfer. By assembling images taken at different time-delays, we make a movie lasting a few tens of picoseconds of the electron transfer process in the photoexcited type-II heterostructure - a fundamental phenomenon in semiconductor devices like solar cells. Quantitative analysis and theoretical modeling of spatial variations in the video provide insight into future solar cells, electron dynamics in 2D materials, and other semiconductor devices.

2D sparse array transducer optimization for 3D ultrasound imaging

International Nuclear Information System (INIS)

Choi, Jae Hoon; Park, Kwan Kyu

2014-01-01

A 3D ultrasound image is desired in many medical examinations. However, the implementation of a 2D array, which is needed for a 3D image, is challenging with respect to fabrication, interconnection and cabling. A 2D sparse array, which needs fewer elements than a dense array, is a realistic way to achieve 3D images. Because the number of ways the elements can be placed in an array is extremely large, a method for optimizing the array configuration is needed. Previous research placed the target point far from the transducer array, making it impossible to optimize the array in the operating range. In our study, we focused on optimizing a 2D sparse array transducer for 3D imaging by using a simulated annealing method. We compared the far-field optimization method with the near-field optimization method by analyzing a point-spread function (PSF). The resolution of the optimized sparse array is comparable to that of the dense array.

WE-AB-BRA-07: Quantitative Evaluation of 2D-2D and 2D-3D Image Guided Radiation Therapy for Clinical Trial Credentialing, NRG Oncology/RTOG

Energy Technology Data Exchange (ETDEWEB)

Giaddui, T; Yu, J; Xiao, Y [Thomas Jefferson University, Philadelphia, PA (United States); Jacobs, P [MIM Software, Inc, Cleavland, Ohio (United States); Manfredi, D; Linnemann, N [IROC Philadelphia, RTQA Center, Philadelphia, PA (United States)

2015-06-15

Purpose: 2D-2D kV image guided radiation therapy (IGRT) credentialing evaluation for clinical trial qualification was historically qualitative through submitting screen captures of the fusion process. However, as quantitative DICOM 2D-2D and 2D-3D image registration tools are implemented in clinical practice for better precision, especially in centers that treat patients with protons, better IGRT credentialing techniques are needed. The aim of this work is to establish methodologies for quantitatively reviewing IGRT submissions based on DICOM 2D-2D and 2D-3D image registration and to test the methodologies in reviewing 2D-2D and 2D-3D IGRT submissions for RTOG/NRG Oncology clinical trials qualifications. Methods: DICOM 2D-2D and 2D-3D automated and manual image registration have been tested using the Harmony tool in MIM software. 2D kV orthogonal portal images are fused with the reference digital reconstructed radiographs (DRR) in the 2D-2D registration while the 2D portal images are fused with DICOM planning CT image in the 2D-3D registration. The Harmony tool allows alignment of the two images used in the registration process and also calculates the required shifts. Shifts calculated using MIM are compared with those submitted by institutions for IGRT credentialing. Reported shifts are considered to be acceptable if differences are less than 3mm. Results: Several tests have been performed on the 2D-2D and 2D-3D registration. The results indicated good agreement between submitted and calculated shifts. A workflow for reviewing these IGRT submissions has been developed and will eventually be used to review IGRT submissions. Conclusion: The IROC Philadelphia RTQA center has developed and tested a new workflow for reviewing DICOM 2D-2D and 2D-3D IGRT credentialing submissions made by different cancer clinical centers, especially proton centers. NRG Center for Innovation in Radiation Oncology (CIRO) and IROC RTQA center continue their collaborative efforts to enhance

WE-AB-BRA-07: Quantitative Evaluation of 2D-2D and 2D-3D Image Guided Radiation Therapy for Clinical Trial Credentialing, NRG Oncology/RTOG

International Nuclear Information System (INIS)

Giaddui, T; Yu, J; Xiao, Y; Jacobs, P; Manfredi, D; Linnemann, N

2015-01-01

Purpose: 2D-2D kV image guided radiation therapy (IGRT) credentialing evaluation for clinical trial qualification was historically qualitative through submitting screen captures of the fusion process. However, as quantitative DICOM 2D-2D and 2D-3D image registration tools are implemented in clinical practice for better precision, especially in centers that treat patients with protons, better IGRT credentialing techniques are needed. The aim of this work is to establish methodologies for quantitatively reviewing IGRT submissions based on DICOM 2D-2D and 2D-3D image registration and to test the methodologies in reviewing 2D-2D and 2D-3D IGRT submissions for RTOG/NRG Oncology clinical trials qualifications. Methods: DICOM 2D-2D and 2D-3D automated and manual image registration have been tested using the Harmony tool in MIM software. 2D kV orthogonal portal images are fused with the reference digital reconstructed radiographs (DRR) in the 2D-2D registration while the 2D portal images are fused with DICOM planning CT image in the 2D-3D registration. The Harmony tool allows alignment of the two images used in the registration process and also calculates the required shifts. Shifts calculated using MIM are compared with those submitted by institutions for IGRT credentialing. Reported shifts are considered to be acceptable if differences are less than 3mm. Results: Several tests have been performed on the 2D-2D and 2D-3D registration. The results indicated good agreement between submitted and calculated shifts. A workflow for reviewing these IGRT submissions has been developed and will eventually be used to review IGRT submissions. Conclusion: The IROC Philadelphia RTQA center has developed and tested a new workflow for reviewing DICOM 2D-2D and 2D-3D IGRT credentialing submissions made by different cancer clinical centers, especially proton centers. NRG Center for Innovation in Radiation Oncology (CIRO) and IROC RTQA center continue their collaborative efforts to enhance

Evaluation of the resolving power of different angles in MPR images of 16DAS-MDCT

International Nuclear Information System (INIS)

Kimura, Mikio; Usui, Junshi; Nozawa, Takeo

2007-01-01

In this study, we evaluated the resolving power of three-dimensional (3D) multiplanar reformation (MPR) images with various angles by using 16 data acquisition system multi detector row computed tomography (16DAS-MDCT). We reconstructed the MPR images using data with a 0.75 mm slice thickness of the axial image in this examination. To evaluate resolving power, we used an original new phantom (RC phantom) that can be positioned at any slice angle in MPR images. We measured the modulation transfer function (MTF) by using the methods of measuring pre-sampling MTF, and used Fourier transform of image data of the square wave chart. The scan condition and image reconstruction condition that were adopted in this study correspond to the condition that we use for three-dimensional computed tomographic angiography(3D-CTA) examination of the head in our hospital. The MTF of MPR images showed minimum values at slice angles in parallel with the axial slice, and showed maximum values at the sagittal slice and coronal slice angles that are parallel to the Z-axis. With an oblique MPR image, MTF did not change with angle changes in the oblique sagittal slice plane, but in the oblique coronal slice plane, MTF increased as the tilt angle increased from the axial plane to the Z plane. As a result, we could evaluate the resolving power of a head 3D image by measuring the MTF of the axial image and sagittal image or the coronal image. (author)

[Evaluation of the resolving power of different angles in MPR images of 16DAS-MDCT].

Science.gov (United States)

Kimura, Mikio; Usui, Junshi; Nozawa, Takeo

2007-03-20

In this study, we evaluated the resolving power of three-dimensional (3D) multiplanar reformation (MPR) images with various angles by using 16 data acquisition system multi detector row computed tomography (16DAS-MDCT) . We reconstructed the MPR images using data with a 0.75 mm slice thickness of the axial image in this examination. To evaluate resolving power, we used an original new phantom (RC phantom) that can be positioned at any slice angle in MPR images. We measured the modulation transfer function (MTF) by using the methods of measuring pre-sampling MTF, and used Fourier transform of image data of the square wave chart. The scan condition and image reconstruction condition that were adopted in this study correspond to the condition that we use for three-dimensional computed tomographic angiography (3D-CTA) examination of the head in our hospital. The MTF of MPR images showed minimum values at slice angles in parallel with the axial slice, and showed maximum values at the sagittal slice and coronal slice angles that are parallel to the Z-axis. With an oblique MPR image, MTF did not change with angle changes in the oblique sagittal slice plane, but in the oblique coronal slice plane, MTF increased as the tilt angle increased from the axial plane to the Z plane. As a result, we could evaluate the resolving power of a head 3D image by measuring the MTF of the axial image and sagittal image or the coronal image.

Methodological development of topographic correction in 2D/3D ToF-SIMS images using AFM images

Science.gov (United States)

Jung, Seokwon; Lee, Nodo; Choi, Myungshin; Lee, Jungmin; Cho, Eunkyunng; Joo, Minho

2018-02-01

Time-of-flight secondary-ion mass spectrometry (ToF-SIMS) is an emerging technique that provides chemical information directly from the surface of electronic materials, e.g. OLED and solar cell. It is very versatile and highly sensitive mass spectrometric technique that provides surface molecular information with their lateral distribution as a two-dimensional (2D) molecular image. Extending the usefulness of ToF-SIMS, a 3D molecular image can be generated by acquiring multiple 2D images in a stack. These imaging techniques by ToF-SIMS provide an insight into understanding the complex structures of unknown composition in electronic material. However, one drawback in ToF-SIMS is not able to represent topographical information in 2D and 3D mapping images. To overcome this technical limitation, topographic information by ex-situ technique such as atomic force microscopy (AFM) has been combined with chemical information from SIMS that provides both chemical and physical information in one image. The key to combine two different images obtained from ToF-SIMS and AFM techniques is to develop the image processing algorithm, which performs resize and alignment by comparing the specific pixel information of each image. In this work, we present methodological development of the semiautomatic alignment and the 3D structure interpolation system for the combination of 2D/3D images obtained by ToF-SIMS and AFM measurements, which allows providing useful analytical information in a single representation.

Time-resolved Particle Image Velocimetry measurements of the 3D random Richtmyer-Meshkov Instability

Science.gov (United States)

Sewell, Everest; Krivets, Vitaliy; Jacobs, Jeffrey

2017-11-01

The vertical shock tube at the University of Arizona is used to perform experiments on the multi-mode three-dimensional Richtmyer-Meshkov Instability (RMI). An interface of air and sulfur hexafluoride is formed in a counter flow configuration, and is excited using voice coils to produce faraday-like multi-modal perturbations.This interface is shock accelerated by an approximately Mach 1.2 shockwave to form the RMI. Time resolved Particle Image Velocimetry (PIV) is used to perform analysis of the evolving instability.

3D structure determination from electron-microscope images: Electron crystallography of staurolite. [HFe[sub 2]Al[sub 9]Si[sub 4]O[sub 24

Energy Technology Data Exchange (ETDEWEB)

Wenk, H.R.; Hu Meisheng (California Univ., Berkeley, CA (United States). Dept. of Geology and Geophysics); Downing, K.H. (Lawrence Berkeley Lab., CA (United States). Donner Lab.); O' Keefe, M.A. (Lawrence Berkeley Lab., CA (United States). National Center for Electron Microscopy)

1992-09-01

Resolution of better than 2 A has been obtained in many crystals by high-resolution electron microscopy. Although this resolution is sufficient to resolve interatomic spacings, structures are traditionally interpreted by comparing experimental images with contrast calculations. A drawback of this method is that images are 2D projections in which information is invariably obscured by overlap of atoms. 3D electron crystallography, developed by biophysicists to study proteins, has been used to investigate the crystal structure of staurolite. Amplitudes and phases of structure factors are obtained experimentally from high-resolution images (JEOL ARM 1000 at the National Center for Electron Microscopy at LBL), taken in different directions from thin regions where dynamic scattering is minimal. From images in five orientations (containing 59 independent reflections to a resolution of 1.38 A), a 3D electron potential map is constructed which resolves clearly all cations (Al, Si, Fe, including those with partial occupancy) and all O atoms. This method has great potential in crystal structure determinations of small domains in heterogeneous crystals which are inaccessible to X-ray analysis. It is estimated that 3D structure determinations should be possible on regions only about ten unit cells wide and should resolve not only atom positions but also site occupancies. The method is also applicable to space-group determination. (orig.).

3D dynamic pituitary MR imaging with CAIPIRINHA: Initial experience and comparison with 2D dynamic MR imaging

Energy Technology Data Exchange (ETDEWEB)

Fushimi, Yasutaka, E-mail: yfushimi@kuhp.kyoto-u.ac.jp [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507 (Japan); Okada, Tomohisa; Kanagaki, Mitsunori; Yamamoto, Akira; Kanda, Yumiko; Sakamoto, Ryo [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507 (Japan); Hojo, Masato; Takahashi, Jun C.; Miyamoto, Susumu [Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507 (Japan); Togashi, Kaori [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507 (Japan)

2014-10-15

Objectives: To evaluate the validity of 3D dynamic pituitary MR imaging with controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA), with special emphasis on demarcation of pituitary posterior lobe and stalk. Methods: Participants comprised 32 patients who underwent dynamic pituitary MR imaging due to pituitary or parasellar lesions. 3D dynamic MR with CAIPIRINHA was performed at 3 T with 20-s-interval, precontrast, 1st to 5th dynamic images. Normalized values and enhanced ratios (dynamic postcontrast image values divided by precontrast ones) were compared between 3D and 2D dynamic MR imaging for patients with visual identification of posterior lobe and stalk. Results: In 3D, stalk was identified in 29 patients and unidentified in 3, and posterior lobe was identified in 28 and unidentified in 4. In 2D, stalk was identified in 26 patients and unidentified in 6 patients, and posterior lobe was identified in 15 and unidentified in 17. Normalized values of pituitary posterior lobe and stalk were higher in 3D than 2D (P < 0.001). No significant difference in enhancement ratio was seen between 3D and 2D. Conclusions: 3D dynamic pituitary MR provided better identification and higher normalized values of pituitary posterior lobe and stalk than 2D.

Time resolved 2-D optical imaging of a pulsed unbalanced magnetron plasma

International Nuclear Information System (INIS)

Bradley, J W; Clarke, G C B; Braithwaite, N St J; Bryant, P M; Kelly, P J

2006-01-01

Using wavelength filtered two dimensional (2-D) optical imaging, the temporal and spatial evolution of selected excited species in a pulsed magnetron discharge has been studied. A titanium target was sputtered at a pulse frequency of 100 kHz, in an argon atmosphere, at an operating pressure of 0.27 Pa. The radial information of the emissivity was determined using the Abel inversion technique. The results show strong excitation of the observed species above the racetrack in the on-time, and the possible development of an ion-acoustic wave, initiated after the off-on transition. The on-off transition is accompanied by a burst of light from the plasma bulk consistent with the transient plasma potential reaching about +200 V. During this phase, we argue that there is a release of secondary electrons from the grounded substrate and walls due to ion bombardment, as well as an increased confinement of energetic plasma electrons. The characteristic decay times of the selected transitions at 750.4, 751.5, 810.4 and 811.5 nm (ArI), present within the bandpass width of our filters, is briefly discussed in terms of the production of fast electrons in the system

Binary-space-partitioned images for resolving image-based visibility.

Science.gov (United States)

Fu, Chi-Wing; Wong, Tien-Tsin; Tong, Wai-Shun; Tang, Chi-Keung; Hanson, Andrew J

2004-01-01

We propose a novel 2D representation for 3D visibility sorting, the Binary-Space-Partitioned Image (BSPI), to accelerate real-time image-based rendering. BSPI is an efficient 2D realization of a 3D BSP tree, which is commonly used in computer graphics for time-critical visibility sorting. Since the overall structure of a BSP tree is encoded in a BSPI, traversing a BSPI is comparable to traversing the corresponding BSP tree. BSPI performs visibility sorting efficiently and accurately in the 2D image space by warping the reference image triangle-by-triangle instead of pixel-by-pixel. Multiple BSPIs can be combined to solve "disocclusion," when an occluded portion of the scene becomes visible at a novel viewpoint. Our method is highly automatic, including a tensor voting preprocessing step that generates candidate image partition lines for BSPIs, filters the noisy input data by rejecting outliers, and interpolates missing information. Our system has been applied to a variety of real data, including stereo, motion, and range images.

Sensitivity enhancement of 13C nuclei in 2D J-resolved NMR spectroscopy using a recycled-flow system

International Nuclear Information System (INIS)

Ha, S.T.K.; Lee, R.W.K.; Wilkins, C.L.

1987-01-01

Recycled-flow nuclear magnetic resonance for sensitivity enhancement in 1/2 spin nuclei has been reported previously, achieving several-fold signal enhancement. The success of the method depends upon premagnetization of nuclei prior to flowing into the detector region, obviating the need for delays following data acquisition to allow spin-lattice relaxation and reduce experiment time. The actual gains of sensitivity enhancement for 13 C- 1 H 2D J-resolved NMR using a recycled-flow method are evaluated. Possible enhancements for two types of J-resolved measurements, namely, one-bond 13 C- 1 H and long range J-resolved spectroscopy, are estimated using a simple Carr-Purcell spin-echo approach to quantify the 13 C signals. The pulse sequence is simply 90 0 -t /sub 1/2/-180 0 -t/sub 1/2/-AT-t/sub d/, where t/sub 1/2/ is half the evolution time, AT is the acquisition time, and t/sub d/ the experiment repetition time. In a static 2D NMR experiment, t/sub d/ usually must be the same order of the longest spin-lattice relaxation time (T 1 ) of nuclei. Quantitative measurements using a recycled-flow system indicate t/dub d/ can be reduced to a fraction of T 1 ; hence significant time savings can be achieved. Time-savings of between 2 and 25 can be anticipated for 2D spectroscopy under flow measurement conditions used in the present study. Other types of 2D NMR spectroscopy (autocorrelation and double quantum NMR) are discussed

Resolving power test of 2-D K{sup +} K{sup +} interferometry

Energy Technology Data Exchange (ETDEWEB)

Padula, Sandra S.; Roldao, Christiane G. [Instituto de Fisica Teorica (IFT), Sao Paulo, SP (Brazil)

1999-07-01

Adopting a procedure previously proposed to quantitatively study pion interferometry {sup 1} , an equivalent 2-D X{sup 2} analysis was performed to test the resolving power of that method when applied to less favorable conditions, when no significant contribution from long lived resonances is expected, as in kaon interferometry. For that purpose, use is made of the preliminary E859 K{sup +}K{sup +} interferometry data from Si+Au collisions at 14.6 A GeV/c. Less sensitivity is achieved in the present case, although it is shown that it is still possible to distinguish two distinct decoupling geometries. (author)

Quantitative imaging of D-2-hydroxyglutarate (D2HG in selected histological tissue areas by a novel bioluminescence technique

Directory of Open Access Journals (Sweden)

Nadine Fabienne Voelxen

2016-03-01

Full Text Available AbstractPatients with malignant gliomas have a poor prognosis with average survival of less than one year. Whereas in other tumor entities the characteristics of tumor metabolism are successfully used for therapeutic approaches, such developments are very rare in brain tumors, notably in gliomas. One metabolic feature characteristic of gliomas, in particular diffuse astrocytomas and oligodendroglial tumors, is the variable content of D-2-hydroxyglutarate (D2HG, a metabolite, which was discovered first in this tumor entity. D2HG is generated in large amounts due to various gain-of–function mutations in the isocitrate dehydrogenases IDH-1 and IDH-2. Meanwhile, D2HG has been detected in several other tumor entities including intrahepatic bile-duct cancer, chondrosarcoma, acute myeloid leukemia, and angioimmunoblastic T-cell lymphoma. D2HG is barely detectable in healthy tissue (< 0.1 mM, but its concentration increases up to 35 mM in malignant tumor tissues. Consequently, the oncometabolite D2HG has gained increasing interest in the field of tumor metabolism. To facilitate its quantitative measurement without loss of spatial resolution at a microscopical level, we have developed a novel bioluminescence assay for determining D2HG in sections of snap-frozen tissue. The assay was verified independently by photometric tests and liquid chromatography / mass spectrometry (LC/MS. The novel technique allows the microscopically resolved determination of D2HG in a concentration range of 0 – 10 µmol/g tissue (wet weight. In combination with the already established bioluminescence imaging techniques for ATP, glucose, pyruvate, and lactate, the novel D2HG assay enables a comparative characterization of the metabolic profile of individual tumors in a further dimension.

Imaging of THz waves in 2D photonic crystal structures embedded in a slab waveguide

International Nuclear Information System (INIS)

Peier, P; Merbold, H; Feurer, T; Pahinin, V; Nelson, K A

2010-01-01

We present space- and time-resolved simulations and measurements of single-cycle terahertz (THz) waves propagating through two-dimensional (2D) photonic crystal structures embedded in a slab waveguide. Specifically, we use a plane wave expansion technique to calculate the band structure and a time-dependent finite-element method to simulate the temporal evolution of the THz waves. Experimentally, we measure the space-time evolution of the THz waves through a coherent time-resolved imaging method. Three different structures are laser machined in LiNbO 3 crystal slabs and analyzing the transmitted as well as the reflected THz waveforms allows determination of the bandgaps. Comparing the results with the calculated band diagrams and the time-dependent simulations shows that the experiments are consistent with 3D simulations, which include the slab waveguide geometry, the birefringence of the material, and a careful analysis of the excited modes within the band diagrams.

2D-Driven 3D Object Detection in RGB-D Images

KAUST Repository

Lahoud, Jean

2017-12-25

In this paper, we present a technique that places 3D bounding boxes around objects in an RGB-D scene. Our approach makes best use of the 2D information to quickly reduce the search space in 3D, benefiting from state-of-the-art 2D object detection techniques. We then use the 3D information to orient, place, and score bounding boxes around objects. We independently estimate the orientation for every object, using previous techniques that utilize normal information. Object locations and sizes in 3D are learned using a multilayer perceptron (MLP). In the final step, we refine our detections based on object class relations within a scene. When compared to state-of-the-art detection methods that operate almost entirely in the sparse 3D domain, extensive experiments on the well-known SUN RGB-D dataset [29] show that our proposed method is much faster (4.1s per image) in detecting 3D objects in RGB-D images and performs better (3 mAP higher) than the state-of-the-art method that is 4.7 times slower and comparably to the method that is two orders of magnitude slower. This work hints at the idea that 2D-driven object detection in 3D should be further explored, especially in cases where the 3D input is sparse.

3D-2D Deformable Image Registration Using Feature-Based Nonuniform Meshes.

Science.gov (United States)

Zhong, Zichun; Guo, Xiaohu; Cai, Yiqi; Yang, Yin; Wang, Jing; Jia, Xun; Mao, Weihua

2016-01-01

By using prior information of planning CT images and feature-based nonuniform meshes, this paper demonstrates that volumetric images can be efficiently registered with a very small portion of 2D projection images of a Cone-Beam Computed Tomography (CBCT) scan. After a density field is computed based on the extracted feature edges from planning CT images, nonuniform tetrahedral meshes will be automatically generated to better characterize the image features according to the density field; that is, finer meshes are generated for features. The displacement vector fields (DVFs) are specified at the mesh vertices to drive the deformation of original CT images. Digitally reconstructed radiographs (DRRs) of the deformed anatomy are generated and compared with corresponding 2D projections. DVFs are optimized to minimize the objective function including differences between DRRs and projections and the regularity. To further accelerate the above 3D-2D registration, a procedure to obtain good initial deformations by deforming the volume surface to match 2D body boundary on projections has been developed. This complete method is evaluated quantitatively by using several digital phantoms and data from head and neck cancer patients. The feature-based nonuniform meshing method leads to better results than either uniform orthogonal grid or uniform tetrahedral meshes.

3D-2D Deformable Image Registration Using Feature-Based Nonuniform Meshes

Directory of Open Access Journals (Sweden)

Zichun Zhong

2016-01-01

Full Text Available By using prior information of planning CT images and feature-based nonuniform meshes, this paper demonstrates that volumetric images can be efficiently registered with a very small portion of 2D projection images of a Cone-Beam Computed Tomography (CBCT scan. After a density field is computed based on the extracted feature edges from planning CT images, nonuniform tetrahedral meshes will be automatically generated to better characterize the image features according to the density field; that is, finer meshes are generated for features. The displacement vector fields (DVFs are specified at the mesh vertices to drive the deformation of original CT images. Digitally reconstructed radiographs (DRRs of the deformed anatomy are generated and compared with corresponding 2D projections. DVFs are optimized to minimize the objective function including differences between DRRs and projections and the regularity. To further accelerate the above 3D-2D registration, a procedure to obtain good initial deformations by deforming the volume surface to match 2D body boundary on projections has been developed. This complete method is evaluated quantitatively by using several digital phantoms and data from head and neck cancer patients. The feature-based nonuniform meshing method leads to better results than either uniform orthogonal grid or uniform tetrahedral meshes.

2D image of local density and magnetic fluctuations from line-integrated interferometry-polarimetry measurements.

Science.gov (United States)

Lin, L; Ding, W X; Brower, D L

2014-11-01

Combined polarimetry-interferometry capability permits simultaneous measurement of line-integrated density and Faraday effect with fast time response (∼1 μs) and high sensitivity. Faraday effect fluctuations with phase shift of order 0.05° associated with global tearing modes are resolved with an uncertainty ∼0.01°. For physics investigations, local density fluctuations are obtained by inverting the line-integrated interferometry data. The local magnetic and current density fluctuations are then reconstructed using a parameterized fit of the polarimetry data. Reconstructed 2D images of density and magnetic field fluctuations in a poloidal cross section exhibit significantly different spatial structure. Combined with their relative phase, the magnetic-fluctuation-induced particle transport flux and its spatial distribution are resolved.

2D image of local density and magnetic fluctuations from line-integrated interferometry-polarimetry measurements

International Nuclear Information System (INIS)

Lin, L.; Ding, W. X.; Brower, D. L.

2014-01-01

Combined polarimetry-interferometry capability permits simultaneous measurement of line-integrated density and Faraday effect with fast time response (∼1 μs) and high sensitivity. Faraday effect fluctuations with phase shift of order 0.05° associated with global tearing modes are resolved with an uncertainty ∼0.01°. For physics investigations, local density fluctuations are obtained by inverting the line-integrated interferometry data. The local magnetic and current density fluctuations are then reconstructed using a parameterized fit of the polarimetry data. Reconstructed 2D images of density and magnetic field fluctuations in a poloidal cross section exhibit significantly different spatial structure. Combined with their relative phase, the magnetic-fluctuation-induced particle transport flux and its spatial distribution are resolved

Stochastic 2-D galaxy disk evolution models. Resolved stellar populations in the galaxy M33

Science.gov (United States)

Mineikis, T.; Vansevičius, V.

We improved the stochastic 2-D galaxy disk models (Mineikis & Vansevičius 2014a) by introducing enriched gas outflows from galaxies and synthetic color-magnitude diagrams of stellar populations. To test the models, we use the HST/ACS stellar photometry data in four fields located along the major axis of the galaxy M33 (Williams et al. 2009) and demonstrate the potential of the models to derive 2-D star formation histories in the resolved disk galaxies.

Filters in 2D and 3D Cardiac SPECT Image Processing

Directory of Open Access Journals (Sweden)

Maria Lyra

2014-01-01

Full Text Available Nuclear cardiac imaging is a noninvasive, sensitive method providing information on cardiac structure and physiology. Single photon emission tomography (SPECT evaluates myocardial perfusion, viability, and function and is widely used in clinical routine. The quality of the tomographic image is a key for accurate diagnosis. Image filtering, a mathematical processing, compensates for loss of detail in an image while reducing image noise, and it can improve the image resolution and limit the degradation of the image. SPECT images are then reconstructed, either by filter back projection (FBP analytical technique or iteratively, by algebraic methods. The aim of this study is to review filters in cardiac 2D, 3D, and 4D SPECT applications and how these affect the image quality mirroring the diagnostic accuracy of SPECT images. Several filters, including the Hanning, Butterworth, and Parzen filters, were evaluated in combination with the two reconstruction methods as well as with a specified MatLab program. Results showed that for both 3D and 4D cardiac SPECT the Butterworth filter, for different critical frequencies and orders, produced the best results. Between the two reconstruction methods, the iterative one might be more appropriate for cardiac SPECT, since it improves lesion detectability due to the significant improvement of image contrast.

Time-resolved PHERMEX image restorations constrained with an additional multiply-exposed image

International Nuclear Information System (INIS)

Kruger, R.P.; Breedlove, J.R. Jr.; Trussell, H.J.

1978-06-01

There are a number of possible industrial and scientific applications of nanosecond cineradiographs. Although the technology exists to produce closely spaced pulses of x rays for this application, the quality of the time-resolved radiographs is severely limited. The limitations arise from the necessity of using a fluorescent screen to convert the transmitted x rays to light and then using electro-optical imaging systems to gate and to record the images with conventional high-speed cameras. It has been proposed that, in addition to the time-resolved images, a conventional multiply exposed radiograph be obtained. This report uses both PHERMEX and conventional photographic simulations to demonstrate that the additional information supplied by the multiply exposed radiograph can be used to improve the quality of digital image restorations of the time-resolved pictures over what could be achieved with the degraded images alone

Computer assisted determination of acetabular cup orientation using 2D-3D image registration

International Nuclear Information System (INIS)

Zheng, Guoyan; Zhang, Xuan

2010-01-01

2D-3D image-based registration methods have been developed to measure acetabular cup orientation after total hip arthroplasty (THA). These methods require registration of both the prosthesis and the CT images to 2D radiographs and compute implant position with respect to a reference. The application of these methods is limited in clinical practice due to two limitations: (1) the requirement of a computer-aided design (CAD) model of the prosthesis, which may be unavailable due to the proprietary concerns of the manufacturer, and (2) the requirement of either multiple radiographs or radiograph-specific calibration, usually unavailable for retrospective studies. In this paper, we propose a new method to address these limitations. A new formulation for determination of post-operative cup orientation, which couples a radiographic measurement with 2D-3D image matching, was developed. In our formulation, the radiographic measurement can be obtained with known methods so that the challenge lies in the 2D-3D image matching. To solve this problem, a hybrid 2D-3D registration scheme combining a landmark-to-ray 2D-3D alignment with a robust intensity-based 2D-3D registration was used. The hybrid 2D-3D registration scheme allows computing both the post-operative cup orientation with respect to an anatomical reference and the pelvic tilt and rotation with respect to the X-ray imaging table/plate. The method was validated using 2D adult cadaver hips. Using the hybrid 2D-3D registration scheme, our method showed a mean accuracy of 1.0 ± 0.7 (range from 0.1 to 2.0 ) for inclination and 1.7 ± 1.2 (range from 0.0 to 3.9 ) for anteversion, taking the measurements from post-operative CT images as ground truths. Our new solution formulation and the hybrid 2D-3D registration scheme facilitate estimation of post-operative cup orientation and measurement of pelvic tilt and rotation. (orig.)

Efficient Sample Delay Calculation for 2-D and 3-D Ultrasound Imaging.

Science.gov (United States)

Ibrahim, Aya; Hager, Pascal A; Bartolini, Andrea; Angiolini, Federico; Arditi, Marcel; Thiran, Jean-Philippe; Benini, Luca; De Micheli, Giovanni

2017-08-01

Ultrasound imaging is a reference medical diagnostic technique, thanks to its blend of versatility, effectiveness, and moderate cost. The core computation of all ultrasound imaging methods is based on simple formulae, except for those required to calculate acoustic propagation delays with high precision and throughput. Unfortunately, advanced three-dimensional (3-D) systems require the calculation or storage of billions of such delay values per frame, which is a challenge. In 2-D systems, this requirement can be four orders of magnitude lower, but efficient computation is still crucial in view of low-power implementations that can be battery-operated, enabling usage in numerous additional scenarios. In this paper, we explore two smart designs of the delay generation function. To quantify their hardware cost, we implement them on FPGA and study their footprint and performance. We evaluate how these architectures scale to different ultrasound applications, from a low-power 2-D system to a next-generation 3-D machine. When using numerical approximations, we demonstrate the ability to generate delay values with sufficient throughput to support 10 000-channel 3-D imaging at up to 30 fps while using 63% of a Virtex 7 FPGA, requiring 24 MB of external memory accessed at about 32 GB/s bandwidth. Alternatively, with similar FPGA occupation, we show an exact calculation method that reaches 24 fps on 1225-channel 3-D imaging and does not require external memory at all. Both designs can be scaled to use a negligible amount of resources for 2-D imaging in low-power applications and for ultrafast 2-D imaging at hundreds of frames per second.

2-d spectroscopic imaging of brain tumours

International Nuclear Information System (INIS)

Ferris, N.J.; Brotchie, P.R.

2002-01-01

Full text: This poster illustrates the use of two-dimensional spectroscopic imaging (2-D SI) in the characterisation of brain tumours, and the monitoring of subsequent treatment. After conventional contrast-enhanced MR imaging of patients with known or suspected brain tumours, 2-D SI is performed at a single axial level. The level is chosen to include the maximum volume of abnormal enhancement, or, in non-enhancing lesions. The most extensive T2 signal abnormality. Two different MR systems have been used (Marconi Edge and GE Signa LX); at each site, a PRESS localisation sequence is employed with TE 128-144 ms. Automated software is used to generate spectral arrays, metabolite maps, and metabolite ratio maps from the spectroscopic data. Colour overlays of the maps onto anatomical images are produced using manufacturer software or the Medex imaging data analysis package. High grade gliomas showed choline levels higher than those in apparently normal brain, with decreases in NAA and creatine. Some lesions showed spectral abnormality extending into otherwise normal appearing brain. This was also seen in a case of CNS lymphoma. Lowgrade lesions showed choline levels similar to normal brain, but with decreased NAA. Only a small number of metastases have been studied, but to date no metastasis has shown spectral abnormality beyond the margins suggested by conventional imaging. Follow-up studies generally show spectral heterogeneity. Regions with choline levels higher than those in normal-appearing brain are considered to represent recurrent high-grade tumour. Some regions show choline to be the dominant metabolite, but its level is not greater than that seen in normal brain. These regions are considered suspicious for residual / recurrent tumour when the choline / creatine ratio exceeds 2 (lower ratios may represent treatment effect). 2-D SI improves the initial assessment of brain tumours, and has potential for influencing the radiotherapy treatment strategy. 2-D SI also

Advanced 3-D Ultrasound Imaging: 3-D Synthetic Aperture Imaging using Fully Addressed and Row-Column Addressed 2-D Transducer Arrays

DEFF Research Database (Denmark)

Bouzari, Hamed

the important diagnostic information in a noninvasive manner. Diagnostic and therapeutic decisions often require accurate estimates of e.g., organ, cyst, or tumor volumes. 3-D ultrasound imaging can provide these measurements without relying on the geometrical assumptions and operator-dependent skills involved...... is one of the factors for the widespread use of ultrasound imaging. The high price tag on the high quality 3-D scanners is limiting their market share. Row-column addressing of 2-D transducer arrays is a low cost alternative to fully addressed 2-D arrays, for 3-D ultrasound imaging. Using row....... Based on a set of acoustical measurements the center frequency, bandwidth, surface pressure, sensitivity, and acoustical cross-talks were evaluated and discussed. The imaging quality assessments were carried out based on Field II simulations as well as phantom measurements. Moreover, an analysis...

3-D Imaging using Row--Column-Addressed 2-D Arrays with a Diverging Lens

DEFF Research Database (Denmark)

Bouzari, Hamed; Engholm, Mathias; Stuart, Matthias Bo

2016-01-01

It has been shown that row–column-addressed (RCA) 2-D arrays can be an inexpensive alternative to fully addressed 2-D arrays. Generally imaging with an RCA 2-D array is limited to its forward-looking volume region. Constructing a double-curved RCA 2-D array or applying a diverging lens over......, is designed for imaging down to 14 cm at a volume rate of 88 Hz. The curvilinear imaging performance of a λ/2-pitch 3 MHz 62+62 RCA 2-D array is investigated as a function of depth, using a diverging lens with f-number of -1. The results of this study demonstrate that the proposed beamforming approach...

Progressive attenuation fields: Fast 2D-3D image registration without precomputation

International Nuclear Information System (INIS)

Rohlfing, Torsten; Russakoff, Daniel B.; Denzler, Joachim; Mori, Kensaku; Maurer, Calvin R. Jr.

2005-01-01

Computation of digitally reconstructed radiograph (DRR) images is the rate-limiting step in most current intensity-based algorithms for the registration of three-dimensional (3D) images to two-dimensional (2D) projection images. This paper introduces and evaluates the progressive attenuation field (PAF), which is a new method to speed up DRR computation. A PAF is closely related to an attenuation field (AF). A major difference is that a PAF is constructed on the fly as the registration proceeds; it does not require any precomputation time, nor does it make any prior assumptions of the patient pose or limit the permissible range of patient motion. A PAF effectively acts as a cache memory for projection values once they are computed, rather than as a lookup table for precomputed projections like standard AFs. We use a cylindrical attenuation field parametrization, which is better suited for many medical applications of 2D-3D registration than the usual two-plane parametrization. The computed attenuation values are stored in a hash table for time-efficient storage and access. Using clinical gold-standard spine image data sets from five patients, we demonstrate consistent speedups of intensity-based 2D-3D image registration using PAF DRRs by a factor of 10 over conventional ray casting DRRs with no decrease of registration accuracy or robustness

Real-time intensity based 2D/3D registration using kV-MV image pairs for tumor motion tracking in image guided radiotherapy

Science.gov (United States)

Furtado, H.; Steiner, E.; Stock, M.; Georg, D.; Birkfellner, W.

2014-03-01

Intra-fractional respiratorymotion during radiotherapy is one of themain sources of uncertainty in dose application creating the need to extend themargins of the planning target volume (PTV). Real-time tumormotion tracking by 2D/3D registration using on-board kilo-voltage (kV) imaging can lead to a reduction of the PTV. One limitation of this technique when using one projection image, is the inability to resolve motion along the imaging beam axis. We present a retrospective patient study to investigate the impact of paired portal mega-voltage (MV) and kV images, on registration accuracy. We used data from eighteen patients suffering from non small cell lung cancer undergoing regular treatment at our center. For each patient we acquired a planning CT and sequences of kV and MV images during treatment. Our evaluation consisted of comparing the accuracy of motion tracking in 6 degrees-of-freedom(DOF) using the anterior-posterior (AP) kV sequence or the sequence of kV-MV image pairs. We use graphics processing unit rendering for real-time performance. Motion along cranial-caudal direction could accurately be extracted when using only the kV sequence but in AP direction we obtained large errors. When using kV-MV pairs, the average error was reduced from 3.3 mm to 1.8 mm and the motion along AP was successfully extracted. The mean registration time was of 190+/-35ms. Our evaluation shows that using kVMV image pairs leads to improved motion extraction in 6 DOF. Therefore, this approach is suitable for accurate, real-time tumor motion tracking with a conventional LINAC.

A time-resolved image sensor for tubeless streak cameras

Science.gov (United States)

Yasutomi, Keita; Han, SangMan; Seo, Min-Woong; Takasawa, Taishi; Kagawa, Keiichiro; Kawahito, Shoji

2014-03-01

This paper presents a time-resolved CMOS image sensor with draining-only modulation (DOM) pixels for tube-less streak cameras. Although the conventional streak camera has high time resolution, the device requires high voltage and bulky system due to the structure with a vacuum tube. The proposed time-resolved imager with a simple optics realize a streak camera without any vacuum tubes. The proposed image sensor has DOM pixels, a delay-based pulse generator, and a readout circuitry. The delay-based pulse generator in combination with an in-pixel logic allows us to create and to provide a short gating clock to the pixel array. A prototype time-resolved CMOS image sensor with the proposed pixel is designed and implemented using 0.11um CMOS image sensor technology. The image array has 30(Vertical) x 128(Memory length) pixels with the pixel pitch of 22.4um. .

2D vs. 3D imaging in laparoscopic surgery-results of a prospective randomized trial.

Science.gov (United States)

Buia, Alexander; Stockhausen, Florian; Filmann, Natalie; Hanisch, Ernst

2017-12-01

3D imaging is an upcoming technology in laparoscopic surgery, and recent studies have shown that the modern 3D technique is superior in an experimental setting. However, the first randomized controlled clinical trial in this context dates back to 1998 and showed no significant difference between 2D and 3D visualization using the first 3D generation technique, which is now more than 15 years old. Positive results measured in an experimental setting considering 3D imaging on surgical performance led us to initiate a randomized controlled pragmatic clinical trial to validate our findings in daily clinical routine. Standard laparoscopic operations (cholecystectomy, appendectomy) were preoperatively randomized to a 2D or 3D imaging system. We used a surgical comfort scale (Likert scale) and the Raw NASA Workload TLX for the subjective assessment of 2D and 3D imaging; the duration of surgery was also measured. The results of 3D imaging were statistically significant better than 2D imaging concerning the parameters "own felt safety" and "task efficiency"; the difficulty level of the procedures in the 2D and 3D groups did not differ. Overall, the Raw NASA Workload TLX showed no significance between the groups. 3D imaging could be a possible advantage in laparoscopic surgery. The results of our clinical trial show increased personal felt safety and efficiency of the surgeon using a 3D imaging system. Overall of the procedures, the findings assessed using Likert scales in terms of own felt safety and task efficiency were statistically significant for 3D imaging. The individually perceived workload assessed with the Raw NASA TLX shows no difference. Although these findings are subjective impressions of the performing surgeons without a clear benefit for 3D technology in clinical outcome, we think that these results show the capability that 3D laparoscopy can have a positive impact while performing laparoscopic procedures.

Wide area 2D/3D imaging development, analysis and applications

CERN Document Server

Langmann, Benjamin

2014-01-01

Imaging technology is an important research area and it is widely utilized in a growing number of disciplines ranging from gaming, robotics and automation to medicine. In the last decade 3D imaging became popular mainly driven by the introduction of novel 3D cameras and measuring devices. These cameras are usually limited to indoor scenes with relatively low distances. Benjamin Langmann introduces medium and long-range 2D/3D cameras to overcome these limitations. He reports measurement results for these devices and studies their characteristic behavior. In order to facilitate the application o

Complex EUV imaging reflectometry: spatially resolved 3D composition determination and dopant profiling with a tabletop 13nm source

Science.gov (United States)

Porter, Christina L.; Tanksalvala, Michael; Gerrity, Michael; Miley, Galen P.; Esashi, Yuka; Horiguchi, Naoto; Zhang, Xiaoshi; Bevis, Charles S.; Karl, Robert; Johnsen, Peter; Adams, Daniel E.; Kapteyn, Henry C.; Murnane, Margaret M.

2018-03-01

With increasingly 3D devices becoming the norm, there is a growing need in the semiconductor industry and in materials science for high spatial resolution, non-destructive metrology techniques capable of determining depth-dependent composition information on devices. We present a solution to this problem using ptychographic coherent diffractive imaging (CDI) implemented using a commercially available, tabletop 13 nm source. We present the design, simulations, and preliminary results from our new complex EUV imaging reflectometer, which uses coherent 13 nm light produced by tabletop high harmonic generation. This tool is capable of determining spatially-resolved composition vs. depth profiles for samples by recording ptychographic images at multiple incidence angles. By harnessing phase measurements, we can locally and nondestructively determine quantities such as device and thin film layer thicknesses, surface roughness, interface quality, and dopant concentration profiles. Using this advanced imaging reflectometer, we can quantitatively characterize materials-sciencerelevant and industry-relevant nanostructures for a wide variety of applications, spanning from defect and overlay metrology to the development and optimization of nano-enhanced thermoelectric or spintronic devices.

Diesel combustion and emissions formation using multiple 2-D imaging diagnostics

Energy Technology Data Exchange (ETDEWEB)

Dec, J.E. [Sandia National Labs., Livermore, CA (United States)

1997-12-31

Understanding how emissions are formed during diesel combustion is central to developing new engines that can comply with increasingly stringent emission standards while maintaining or improving performance levels. Laser-based planar imaging diagnostics are uniquely capable of providing the temporally and spatially resolved information required for this understanding. Using an optically accessible research engine, a variety of two-dimensional (2-D) imaging diagnostics have been applied to investigators of direct-injection (DI) diesel combustion and emissions formation. These optical measurements have included the following laser-sheet imaging data: Mie scattering to determine liquid-phase fuel distributions, Rayleigh scattering for quantitative vapor-phase-fuel/air mixture images, laser induced incandescence (LII) for relative soot concentrations, simultaneous LII and Rayleigh scattering for relative soot particle-size distributions, planar laser-induced fluorescence (PLIF) to obtain early PAH (polyaromatic hydrocarbon) distributions, PLIF images of the OH radical that show the diffusion flame structure, and PLIF images of the NO radical showing the onset of NO{sub x} production. In addition, natural-emission chemiluminescence images were obtained to investigate autoignition. The experimental setup is described, and the image data showing the most relevant results are presented. Then the conceptual model of diesel combustion is summarized in a series of idealized schematics depicting the temporal and spatial evolution of a reacting diesel fuel jet during the time period investigated. Finally, recent PLIF images of the NO distribution are presented and shown to support the timing and location of NO formation hypothesized from the conceptual model.

Pro-Resolving Effects of Resolvin D2 in LTD4 and TNF-α Pre-Treated Human Bronchi.

Directory of Open Access Journals (Sweden)

Rayan Khaddaj-Mallat

Full Text Available Inflammation is a major burden in respiratory diseases, resulting in airway hyperresponsiveness. Our hypothesis is that resolution of inflammation may represent a long-term solution in preventing human bronchial dysfunctions. The aim of the present study was to assess the anti-inflammatory effects of RvD2, a member of the D-series resolving family, with concomitant effects on ASM mechanical reactivity. The role and mode of action of RvD2 were assessed in an in vitro model of human bronchi under pro-inflammatory conditions, induced either by 1 μM LTD4 or 10 ng/ml TNF-α pre-treatment for 48h. TNF-α and LTD4 both induced hyperreactivity in response to pharmacological stimuli. Enhanced 5-Lipoxygenase (5-LOX and cysteinyl leukotriene receptor 1 (CysLTR1 detection was documented in LTD4 or TNF-α pre-treated human bronchi when compared to control (untreated human bronchi. In contrast, RvD2 treatments reversed 5-LOX/β-actin and CysLTR1/β-actin ratios and decreased the phosphorylation levels of AP-1 subunits (c-Fos, c-Jun and p38-MAP kinase, while increasing the detection of the ALX/FPR2 receptor. Moreover, various pharmacological agents revealed the blunting effects of RvD2 on LTD4 or TNF-α induced hyper-responsiveness. Combined treatment with 300 nM RvD2 and 1 μM WRW4 (an ALX/FPR2 receptor inhibitor blunted the pro-resolving and broncho-modulatory effects of RvD2. The present data provide new evidence regarding the role of RvD2 in a human model of airway inflammation and hyperrresponsiveness.

Subnuclear foci quantification using high-throughput 3D image cytometry

Science.gov (United States)

Wadduwage, Dushan N.; Parrish, Marcus; Choi, Heejin; Engelward, Bevin P.; Matsudaira, Paul; So, Peter T. C.

2015-07-01

Ionising radiation causes various types of DNA damages including double strand breaks (DSBs). DSBs are often recognized by DNA repair protein ATM which forms gamma-H2AX foci at the site of the DSBs that can be visualized using immunohistochemistry. However most of such experiments are of low throughput in terms of imaging and image analysis techniques. Most of the studies still use manual counting or classification. Hence they are limited to counting a low number of foci per cell (5 foci per nucleus) as the quantification process is extremely labour intensive. Therefore we have developed a high throughput instrumentation and computational pipeline specialized for gamma-H2AX foci quantification. A population of cells with highly clustered foci inside nuclei were imaged, in 3D with submicron resolution, using an in-house developed high throughput image cytometer. Imaging speeds as high as 800 cells/second in 3D were achieved by using HiLo wide-field depth resolved imaging and a remote z-scanning technique. Then the number of foci per cell nucleus were quantified using a 3D extended maxima transform based algorithm. Our results suggests that while most of the other 2D imaging and manual quantification studies can count only up to about 5 foci per nucleus our method is capable of counting more than 100. Moreover we show that 3D analysis is significantly superior compared to the 2D techniques.

3D T2-weighted imaging to shorten multiparametric prostate MRI protocols.

Science.gov (United States)

Polanec, Stephan H; Lazar, Mathias; Wengert, Georg J; Bickel, Hubert; Spick, Claudio; Susani, Martin; Shariat, Shahrokh; Clauser, Paola; Baltzer, Pascal A T

2018-04-01

To determine whether 3D acquisitions provide equivalent image quality, lesion delineation quality and PI-RADS v2 performance compared to 2D acquisitions in T2-weighted imaging of the prostate at 3 T. This IRB-approved, prospective study included 150 consecutive patients (mean age 63.7 years, 35-84 years; mean PSA 7.2 ng/ml, 0.4-31.1 ng/ml). Two uroradiologists (R1, R2) independently rated image quality and lesion delineation quality using a five-point ordinal scale and assigned a PI-RADS score for 2D and 3D T2-weighted image data sets. Data were compared using visual grading characteristics (VGC) and receiver operating characteristics (ROC)/area under the curve (AUC) analysis. Image quality was similarly good to excellent for 2D T2w (mean score R1, 4.3 ± 0.81; R2, 4.7 ± 0.83) and 3D T2w (mean score R1, 4.3 ± 0.82; R2, 4.7 ± 0.69), p = 0.269. Lesion delineation was rated good to excellent for 2D (mean score R1, 4.16 ± 0.81; R2, 4.19 ± 0.92) and 3D T2w (R1, 4.19 ± 0.94; R2, 4.27 ± 0.94) without significant differences (p = 0.785). ROC analysis showed an equivalent performance for 2D (AUC 0.580-0.623) and 3D (AUC 0.576-0.629) T2w (p > 0.05, respectively). Three-dimensional acquisitions demonstrated equivalent image and lesion delineation quality, and PI-RADS v2 performance, compared to 2D in T2-weighted imaging of the prostate. Three-dimensional T2-weighted imaging could be used to considerably shorten prostate MRI protocols in clinical practice. • 3D shows equivalent image quality and lesion delineation compared to 2D T2w. • 3D T2w and 2D T2w image acquisition demonstrated comparable diagnostic performance. • Using a single 3D T2w acquisition may shorten the protocol by 40%. • Combined with short DCE, multiparametric protocols of 10 min are feasible.

Depth-resolved ballistic imaging in a low-depth-of-field optical Kerr gated imaging system

Energy Technology Data Exchange (ETDEWEB)

Zheng, Yipeng; Tan, Wenjiang, E-mail: tanwenjiang@mail.xjtu.edu.cn; Si, Jinhai; Ren, YuHu; Xu, Shichao; Hou, Xun [Key Laboratory for Physical Electronics and Devices of the Ministry of Education and Shaanxi Key Lab of Information Photonic Technique, School of Electronics and Information Engineering, Xi' an Jiaotong University, Xianning-xilu 28, Xi' an 710049 (China); Tong, Junyi [Departments of Applied Physics, Xi' an University of Technology, Xi' an 710048 (China)

2016-09-07

We demonstrate depth-resolved imaging in a ballistic imaging system, in which a heterodyned femtosecond optical Kerr gate is introduced to extract useful imaging photons for detecting an object hidden in turbid media and a compound lens is proposed to ensure both the depth-resolved imaging capability and the long working distance. Two objects of about 15-μm widths hidden in a polystyrene-sphere suspension have been successfully imaged with approximately 600-μm depth resolution. Modulation-transfer-function curves with the object in and away from the object plane have also been measured to confirm the depth-resolved imaging capability of the low-depth-of-field (low-DOF) ballistic imaging system. This imaging approach shows potential for application in research of the internal structure of highly scattering fuel spray.

4D rotational x-ray imaging of wrist joint dynamic motion

International Nuclear Information System (INIS)

Carelsen, Bart; Bakker, Niels H.; Strackee, Simon D.; Boon, Sjirk N.; Maas, Mario; Sabczynski, Joerg; Grimbergen, Cornelis A.; Streekstra, Geert J.

2005-01-01

Current methods for imaging joint motion are limited to either two-dimensional (2D) video fluoroscopy, or to animated motions from a series of static three-dimensional (3D) images. 3D movement patterns can be detected from biplane fluoroscopy images matched with computed tomography images. This involves several x-ray modalities and sophisticated 2D to 3D matching for the complex wrist joint. We present a method for the acquisition of dynamic 3D images of a moving joint. In our method a 3D-rotational x-ray (3D-RX) system is used to image a cyclically moving joint. The cyclic motion is synchronized to the x-ray acquisition to yield multiple sets of projection images, which are reconstructed to a series of time resolved 3D images, i.e., four-dimensional rotational x ray (4D-RX). To investigate the obtained image quality parameters the full width at half maximum (FWHM) of the point spread function (PSF) via the edge spread function and the contrast to noise ratio between air and phantom were determined on reconstructions of a bullet and rod phantom, using 4D-RX as well as stationary 3D-RX images. The CNR in volume reconstructions based on 251 projection images in the static situation and on 41 and 34 projection images of a moving phantom were 6.9, 3.0, and 2.9, respectively. The average FWHM of the PSF of these same images was, respectively, 1.1, 1.7, and 2.2 mm orthogonal to the motion and parallel to direction of motion 0.6, 0.7, and 1.0 mm. The main deterioration of 4D-RX images compared to 3D-RX images is due to the low number of projection images used and not to the motion of the object. Using 41 projection images seems the best setting for the current system. Experiments on a postmortem wrist show the feasibility of the method for imaging 3D dynamic joint motion. We expect that 4D-RX will pave the way to improved assessment of joint disorders by detection of 3D dynamic motion patterns in joints

Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography

Science.gov (United States)

Dempsey, Laura A.; Cooper, Robert J.; Powell, Samuel; Edwards, Andrea; Lee, Chuen-Wai; Brigadoi, Sabrina; Everdell, Nick; Arridge, Simon; Gibson, Adam P.; Austin, Topun; Hebden, Jeremy C.

2015-07-01

We present a method for acquiring whole-head images of changes in blood volume and oxygenation from the infant brain at cot-side using time-resolved diffuse optical tomography (TR-DOT). At UCL, we have built a portable TR-DOT device, known as MONSTIR II, which is capable of obtaining a whole-head (1024 channels) image sequence in 75 seconds. Datatypes extracted from the temporal point spread functions acquired by the system allow us to determine changes in absorption and reduced scattering coefficients within the interrogated tissue. This information can then be used to define clinically relevant measures, such as oxygen saturation, as well as to reconstruct images of relative changes in tissue chromophore concentration, notably those of oxy- and deoxyhaemoglobin. Additionally, the effective temporal resolution of our system is improved with spatio-temporal regularisation implemented through a Kalman filtering approach, allowing us to image transient haemodynamic changes. By using this filtering technique with intensity and mean time-of-flight datatypes, we have reconstructed images of changes in absorption and reduced scattering coefficients in a dynamic 2D phantom. These results demonstrate that MONSTIR II is capable of resolving slow changes in tissue optical properties within volumes that are comparable to the preterm head. Following this verification study, we are progressing to imaging a 3D dynamic phantom as well as the neonatal brain at cot-side. Our current study involves scanning healthy babies to demonstrate the quality of recordings we are able to achieve in this challenging patient population, with the eventual goal of imaging functional activation and seizures.

A CANDELS-3D-HST synergy : Resolved Star Formation Patterns at 0.7

NARCIS (Netherlands)

Wuyts, S.; , van, Dokkum P.G.; , van der, Wel A.

2013-01-01

We analyze the resolved stellar populations of 473 massive star-forming galaxies at 0.7 {lt} z {lt} 1.5, with multi-wavelength broadband imaging from CANDELS and H{$α$} surface brightness profiles at the same kiloparsec resolution from 3D-HST. Together, this unique data set sheds light on how the

Image recovery from defocused 2D fluorescent images in multimodal digital holographic microscopy.

Science.gov (United States)

Quan, Xiangyu; Matoba, Osamu; Awatsuji, Yasuhiro

2017-05-01

A technique of three-dimensional (3D) intensity retrieval from defocused, two-dimensional (2D) fluorescent images in the multimodal digital holographic microscopy (DHM) is proposed. In the multimodal DHM, 3D phase and 2D fluorescence distributions are obtained simultaneously by an integrated system of an off-axis DHM and a conventional epifluorescence microscopy, respectively. This gives us more information of the target; however, defocused fluorescent images are observed due to the short depth of field. In this Letter, we propose a method to recover the defocused images based on the phase compensation and backpropagation from the defocused plane to the focused plane using the distance information that is obtained from a 3D phase distribution. By applying Zernike polynomial phase correction, we brought back the fluorescence intensity to the focused imaging planes. The experimental demonstration using fluorescent beads is presented, and the expected applications are suggested.

A fast, accurate, and automatic 2D-3D image registration for image-guided cranial radiosurgery

International Nuclear Information System (INIS)

Fu Dongshan; Kuduvalli, Gopinath

2008-01-01

The authors developed a fast and accurate two-dimensional (2D)-three-dimensional (3D) image registration method to perform precise initial patient setup and frequent detection and correction for patient movement during image-guided cranial radiosurgery treatment. In this method, an approximate geometric relationship is first established to decompose a 3D rigid transformation in the 3D patient coordinate into in-plane transformations and out-of-plane rotations in two orthogonal 2D projections. Digitally reconstructed radiographs are generated offline from a preoperative computed tomography volume prior to treatment and used as the reference for patient position. A multiphase framework is designed to register the digitally reconstructed radiographs with the x-ray images periodically acquired during patient setup and treatment. The registration in each projection is performed independently; the results in the two projections are then combined and converted to a 3D rigid transformation by 2D-3D geometric backprojection. The in-plane transformation and the out-of-plane rotation are estimated using different search methods, including multiresolution matching, steepest descent minimization, and one-dimensional search. Two similarity measures, optimized pattern intensity and sum of squared difference, are applied at different registration phases to optimize accuracy and computation speed. Various experiments on an anthropomorphic head-and-neck phantom showed that, using fiducial registration as a gold standard, the registration errors were 0.33±0.16 mm (s.d.) in overall translation and 0.29 deg. ±0.11 deg. (s.d.) in overall rotation. The total targeting errors were 0.34±0.16 mm (s.d.), 0.40±0.2 mm (s.d.), and 0.51±0.26 mm (s.d.) for the targets at the distances of 2, 6, and 10 cm from the rotation center, respectively. The computation time was less than 3 s on a computer with an Intel Pentium 3.0 GHz dual processor

2D VS 3D imaging of brain tumours with 18F-Fluoromisonidazole (FMISO) and positron emission tomography (PET)

International Nuclear Information System (INIS)

Pathmaraj, K.; Scott, A.M.; Egan, G.F.; Hannah, A.; Tauro, A.; Tochon-Danguy, A.; Sachinidis, J.; Berlangieri, S.U.; Fabinyi, G.; McKay, W.J.; Cher, L.

1998-01-01

Full text: 18 F-FMISO accumulates in hypoxic cells and can be used in the PET imaging of brain tumours containing viable but hypoxic cells. The limited activity (typically 130 MBq) of injected 18 F-FMISO yield poor statistics, requiring prolonged imaging in the conventional 2D mode of PET scanning. 3D (septa retracted) imaging allows for more counts to be collected over a shorter time period making it a more practical alternative. This study investigates the contrast resolution that can be obtained from 3D PET scans compared to the corresponding 2D scan. A patient recently diagnosed with brain tumour was injected with 18 -FMISO 2 hours prior to scanning and imaged supine on a 951/31R PET scanner with the head secured firmly in a head holder. The imaging protocol consisted of a 3 min emission rectilinear scan to position the brain in the FOV, a 10 min post-emission transmission scan, a 20 min 2D emission scan and a 5X10 min frames 3D emission scan. Both the 2D and 3D scans were reconstructed with filtered backprojection algorithm. The first 10 min frame of the 3D acquisition was reconstructed. The total true counts were 3 million and 6.06 million in the 2D image and 3D images respectively. The random events were 0.24 million and 0.96 million in the 2D and 3D images respectively. The Noise Equivalent Counts (NEC) were 2.2 million and 2.02 million for the 2D and 3D images respectively indicating that the 2D and 3D scans (in spite of the nominal true events being vastly different in the 2 scans) had similar Signal to Noise Ratio (SNR). Circular ROI's were defined in the tumour and the contralateral cortex in comparable transaxial slices of the 2D and 3D images. Contrast resolution of the tumour to the background was calculated as 1.4 and 1.38 in the 2D and 3D images respectively. Thus comparable contrast resolution is obtained in the brain with both 3D and 2D images, making 3D imaging a viable alternative to 2D imaging and greatly reducing imaging time. Optimum time

Comparison of modern 3D and 2D MR imaging sequences of the wrist at 3 Tesla

International Nuclear Information System (INIS)

Rehnitz, C.; Klaan, B.; Amarteifio, E.; Kauczor, H.U.; Weber, M.A.; Stillfried, F. von; Burkholder, I.

2016-01-01

To compare the image quality of modern 3 D and 2 D sequences for dedicated wrist imaging at 3 Tesla (T) MRI. At 3 T MRI, 18 patients (mean age: 36.2 years) with wrist pain and 16 healthy volunteers (mean age: 26.4 years) were examined using 2 D proton density-weighted fat-saturated (PDfs), isotropic 3 D TrueFISP, 3 D MEDIC, and 3 D PDfs SPACE sequences. Image quality was rated on a five-point scale (0 - 4) including overall image quality (OIQ), visibility of important structures (cartilage, ligaments, TFCC) and degree of artifacts. Signal-to-noise ratios (SNR) and contrast-to-noise ratios (CNR) of cartilage/bone/muscle/fluid as well as the mean overall SNR/CNR were calculated using region-of-interest analysis. ANOVA, paired t-, and Wilcoxon-signed-rank tests were applied. The image quality of all tested sequences was superior to 3 D PDfs SPACE (p < 0.01). 3 D TrueFISP had the highest combined cartilage score (mean: 3.4) and performed better in cartilage comparisons against 3 D PDfs SPACE in both groups and 2 D PDfs in volunteers (p < 0.05). 3 D MEDIC performed better in 7 of 8 comparisons (p < 0.05) regarding ligaments and TFCC. 2 D PDfs provided constantly high scores. The mean overall SNR/CNR for 2 D PDfs, 3 D PDfs SPACE, 3 D TrueFISP, and 3 D MEDIC were 68/65, 32/27, 45/47, and 57/45, respectively. 2 D PDfs performed best in most SNR/CNR comparisons (p < 0.05) and 3 D MEDIC performed best within the 3 D sequences (p < 0.05). Except 3 D PDfs SPACE, all tested 3 D and 2 D sequences provided high image quality. 3 D TrueFISP was best for cartilage imaging, 3 D MEDIC for ligaments and TFCC and 2 D PDfs for general wrist imaging.

Highly resolved measurements of atmospheric turbulence with the new 2d-Atmospheric Laser Cantilever Anemometer

International Nuclear Information System (INIS)

Jeromin, A; Schaffarczyk, A P; Puczylowski, J; Peinke, J; Hölling, M

2014-01-01

For the investigation of atmospheric turbulent flows on small scales a new anemometer was developed, the so-called 2d-Atmospheric Laser Cantilever Anemometer (2d-ALCA). It performs highly resolved measurements with a spatial resolution in millimeter range and temporal resolution in kHz range, thus detecting very small turbulent structures. The anemometer is a redesign of the successfully operating 2d-LCA for laboratory application. The new device was designed to withstand hostile operating environments (rain and saline, humid air). In February 2012, the 2d-ALCA was used for the first time in a test field. The device was mounted in about 53 m above ground level on a lattice tower near the German North Sea coast. Wind speed was measured by the 2d-ALCA at 10 kHz sampling rate and by cup anemometers at 1 Hz. The instantaneous wind speed ranged from 8 m/s to 19 m/s at an average turbulence level of about 7 %. Wind field characteristics were analyzed based on cup anemometer as well as 2d-ALCA. The combination of both devices allowed the study of atmospheric turbulence over several magnitudes in turbulent scales

Angle-resolved imaging of single-crystal materials with MeV helium ions

Energy Technology Data Exchange (ETDEWEB)

Strathman, M D; Baumann, S [Charles Evans and Associates, Redwood City, CA (United States)

1992-02-01

The simplest form of angle-resolved mapping for single-crystal materials is the creation of a channeling angular scan. Several laboratories have expanded this simple procedure to include mapping as a function of two independent tilts. These angle-resolved images are particularly suited to the assessment of crystal parameters including disorder, lattice location of impurities, and lattice stress. This paper will describe the use of the Charles Evans and Associates RBS-400 scattering chamber for acquisition, display, and analysis of angle-resolved images obtained from backscattered helium ions. Typical data acquisition times are 20 min for a {+-}2deg X-Y tilt scan with 2500 pixels (8/100deg resolution), and 10 nC per pixel. In addition, we will present a method for automatically aligning crystals for channeling measurements based on this imaging technology. (orig.).

Angle-resolved imaging of single-crystal materials with MeV helium ions

International Nuclear Information System (INIS)

Strathman, M.D.; Baumann, S.

1992-01-01

The simplest form of angle-resolved mapping for single-crystal materials is the creation of a channeling angular scan. Several laboratories have expanded this simple procedure to include mapping as a function of two independent tilts. These angle-resolved images are particularly suited to the assessment of crystal parameters including disorder, lattice location of impurities, and lattice stress. This paper will describe the use of the Charles Evans and Associates RBS-400 scattering chamber for acquisition, display, and analysis of angle-resolved images obtained from backscattered helium ions. Typical data acquisition times are 20 min for a ±2deg X-Y tilt scan with 2500 pixels (8/100deg resolution), and 10 nC per pixel. In addition, we will present a method for automatically aligning crystals for channeling measurements based on this imaging technology. (orig.)

Respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK): Initial clinical experience on an MRI-guided radiotherapy system.

Science.gov (United States)

Han, Fei; Zhou, Ziwu; Du, Dongsu; Gao, Yu; Rashid, Shams; Cao, Minsong; Shaverdian, Narek; Hegde, John V; Steinberg, Michael; Lee, Percy; Raldow, Ann; Low, Daniel A; Sheng, Ke; Yang, Yingli; Hu, Peng

2018-06-01

To optimize and evaluate the respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK-4D-MRI) method in a 0.35 T MRI-guided radiotherapy (MRgRT) system. The study included seven patients with abdominal tumors treated on the MRgRT system. ROCK-4D-MRI and 2D-CINE, was performed immediately after one of the treatment fractions. Motion quantification based on 4D-MRI was compared with those based on 2D-CINE. The image quality of 4D-MRI was evaluated against 4D-CT. The gross tumor volumes (GTV) were defined based on individual respiratory phases of both 4D-MRI and 4D-CT and compared for their variability over the respiratory cycle. The motion measurements based on 4D-MRI matched well with 2D-CINE, with differences of 1.04 ± 0.52 mm in the superior-inferior and 0.54 ± 0.21 mm in the anterior-posterior directions. The image quality scores of 4D-MRI were significantly higher than 4D-CT, with better tumor contrast (3.29 ± 0.76 vs. 1.86 ± 0.90) and less motion artifacts (3.57 ± 0.53 vs. 2.29 ± 0.95). The GTVs were more consistent in 4D-MRI than in 4D-CT, with significantly smaller GTV variability (9.31 ± 4.58% vs. 34.27 ± 23.33%). Our study demonstrated the clinical feasibility of using the ROCK-4D-MRI to acquire high quality, respiratory motion-resolved 4D-MRI in a low-field MRgRT system. The 4D-MRI image could provide accurate dynamic information for radiotherapy treatment planning. Copyright © 2018 Elsevier B.V. All rights reserved.

Volumetric Synthetic Aperture Imaging with a Piezoelectric 2-D Row-Column Probe

DEFF Research Database (Denmark)

Bouzari, Hamed; Engholm, Mathias; Christiansen, Thomas Lehrmann

2016-01-01

The synthetic aperture (SA) technique can be used for achieving real-time volumetric ultrasound imaging using 2-D row-column addressed transducers. This paper investigates SA volumetric imaging performance of an in-house prototyped 3 MHz λ/2-pitch 62+62 element piezoelectric 2-D row-column addres......The synthetic aperture (SA) technique can be used for achieving real-time volumetric ultrasound imaging using 2-D row-column addressed transducers. This paper investigates SA volumetric imaging performance of an in-house prototyped 3 MHz λ/2-pitch 62+62 element piezoelectric 2-D row...

Simultaneous 3D–2D image registration and C-arm calibration: Application to endovascular image-guided interventions

Energy Technology Data Exchange (ETDEWEB)

Mitrović, Uroš [Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, Ljubljana 1000, Slovenia and Cosylab, Control System Laboratory, Teslova ulica 30, Ljubljana 1000 (Slovenia); Pernuš, Franjo [Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, Ljubljana 1000 (Slovenia); Likar, Boštjan; Špiclin, Žiga, E-mail: ziga.spiclin@fe.uni-lj.si [Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, Ljubljana 1000, Slovenia and Sensum, Computer Vision Systems, Tehnološki Park 21, Ljubljana 1000 (Slovenia)

2015-11-15

Purpose: Three-dimensional to two-dimensional (3D–2D) image registration is a key to fusion and simultaneous visualization of valuable information contained in 3D pre-interventional and 2D intra-interventional images with the final goal of image guidance of a procedure. In this paper, the authors focus on 3D–2D image registration within the context of intracranial endovascular image-guided interventions (EIGIs), where the 3D and 2D images are generally acquired with the same C-arm system. The accuracy and robustness of any 3D–2D registration method, to be used in a clinical setting, is influenced by (1) the method itself, (2) uncertainty of initial pose of the 3D image from which registration starts, (3) uncertainty of C-arm’s geometry and pose, and (4) the number of 2D intra-interventional images used for registration, which is generally one and at most two. The study of these influences requires rigorous and objective validation of any 3D–2D registration method against a highly accurate reference or “gold standard” registration, performed on clinical image datasets acquired in the context of the intervention. Methods: The registration process is split into two sequential, i.e., initial and final, registration stages. The initial stage is either machine-based or template matching. The latter aims to reduce possibly large in-plane translation errors by matching a projection of the 3D vessel model and 2D image. In the final registration stage, four state-of-the-art intrinsic image-based 3D–2D registration methods, which involve simultaneous refinement of rigid-body and C-arm parameters, are evaluated. For objective validation, the authors acquired an image database of 15 patients undergoing cerebral EIGI, for which accurate gold standard registrations were established by fiducial marker coregistration. Results: Based on target registration error, the obtained success rates of 3D to a single 2D image registration after initial machine-based and

Extracting 3D parametric curves from 2D images of helical objects.

OpenAIRE

Willcocks, Chris; Jackson, Philip T.G.; Nelson, Carl J.; Obara, Boguslaw

2016-01-01

Helical objects occur in medicine, biology, cosmetics, nanotechnology, and engineering. Extracting a 3D parametric curve from a 2D image of a helical object has many practical applications, in particular being able to extract metrics such as tortuosity, frequency, and pitch. We present a method that is able to straighten the image object and derive a robust 3D helical curve from peaks in the object boundary. The algorithm has a small number of stable parameters that require little tuning, and...

Estimating 3D Object Parameters from 2D Grey-Level Images

NARCIS (Netherlands)

Houkes, Z.

2000-01-01

This thesis describes a general framework for parameter estimation, which is suitable for computer vision applications. The approach described combines 3D modelling, animation and estimation tools to determine parameters of objects in a scene from 2D grey-level images. The animation tool predicts

A multi-frequency electrical impedance tomography system for real-time 2D and 3D imaging

Science.gov (United States)

Yang, Yunjie; Jia, Jiabin

2017-08-01

This paper presents the design and evaluation of a configurable, fast multi-frequency Electrical Impedance Tomography (mfEIT) system for real-time 2D and 3D imaging, particularly for biomedical imaging. The system integrates 32 electrode interfaces and the current frequency ranges from 10 kHz to 1 MHz. The system incorporates the following novel features. First, a fully adjustable multi-frequency current source with current monitoring function is designed. Second, a flexible switching scheme is developed for arbitrary sensing configuration and a semi-parallel data acquisition architecture is implemented for high-frame-rate data acquisition. Furthermore, multi-frequency digital quadrature demodulation is accomplished in a high-capacity Field Programmable Gate Array. At last, a 3D imaging software, visual tomography, is developed for real-time 2D and 3D image reconstruction, data analysis, and visualization. The mfEIT system is systematically tested and evaluated from the aspects of signal to noise ratio (SNR), frame rate, and 2D and 3D multi-frequency phantom imaging. The highest SNR is 82.82 dB on a 16-electrode sensor. The frame rate is up to 546 fps at serial mode and 1014 fps at semi-parallel mode. The evaluation results indicate that the presented mfEIT system is a powerful tool for real-time 2D and 3D imaging.

2D imaging and 3D sensing data acquisition and mutual registration for painting conservation

Science.gov (United States)

Fontana, Raffaella; Gambino, Maria Chiara; Greco, Marinella; Marras, Luciano; Pampaloni, Enrico M.; Pelagotti, Anna; Pezzati, Luca; Poggi, Pasquale

2005-01-01

We describe the application of 2D and 3D data acquisition and mutual registration to the conservation of paintings. RGB color image acquisition, IR and UV fluorescence imaging, together with the more recent hyperspectral imaging (32 bands) are among the most useful techniques in this field. They generally are meant to provide information on the painting materials, on the employed techniques and on the object state of conservation. However, only when the various images are perfectly registered on each other and on the 3D model, no ambiguity is possible and safe conclusions may be drawn. We present the integration of 2D and 3D measurements carried out on two different paintings: "Madonna of the Yarnwinder" by Leonardo da Vinci, and "Portrait of Lionello d'Este", by Pisanello, both painted in the XV century.

Improved Focusing Method for 3-D Imaging using Row–Column-Addressed 2-D Arrays

DEFF Research Database (Denmark)

Bouzari, Hamed; Engholm, Mathias; Stuart, Matthias Bo

2017-01-01

A row–column-addressed (RCA) 2-D array can be interpreted as two orthogonal 1-D arrays. By transmitting with row elements and receiving the echoes through column elements or vice versa, a rectilinear volume in front of the array can be beamformed. Since the transmit and receive 1-D arrays are ort...... measurements with a PZT λ/2-pitch 3 MHz 62+62 RCA 2-D transducer probe. A synthetic aperture imaging sequence with single element transmissions at a time, is designed for imaging down to 14 cm at a volume rate of 44 Hz....

Time-resolved diffusion tomographic imaging in highly scattering turbid media

Science.gov (United States)

Alfano, Robert R. (Inventor); Cai, Wei (Inventor); Liu, Feng (Inventor); Lax, Melvin (Inventor); Das, Bidyut B. (Inventor)

1998-01-01

A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and time-resolving equipment to generate a plurality of time-resolved intensity curves for the diffusive component of light emergent from the medium. For each of the curves, the intensities at a plurality of times are then inputted into the following inverse reconstruction algorithm to form an image of the medium: X.sup.(k+1).spsp.T =?Y.sup.T W+X.sup.(k).spsp.T .LAMBDA.!?W.sup.T W+.LAMBDA.!.sup.-1 wherein W is a matrix relating output at detector position r.sub.d, at time t, to source at position r.sub.s, .LAMBDA. is a regularization matrix, chosen for convenience to be diagonal, but selected in a way related to the ratio of the noise, to fluctuations in the absorption (or diffusion) X.sub.j that we are trying to determine: .LAMBDA..sub.ij =.lambda..sub.j .delta..sub.ij with .lambda..sub.j =/ Here Y is the data collected at the detectors, and X.sup.k is the kth iterate toward the desired absoption information.

3D-2D registration in endovascular image-guided surgery: evaluation of state-of-the-art methods on cerebral angiograms.

Science.gov (United States)

Mitrović, Uroš; Likar, Boštjan; Pernuš, Franjo; Špiclin, Žiga

2018-02-01

Image guidance for minimally invasive surgery is based on spatial co-registration and fusion of 3D pre-interventional images and treatment plans with the 2D live intra-interventional images. The spatial co-registration or 3D-2D registration is the key enabling technology; however, the performance of state-of-the-art automated methods is rather unclear as they have not been assessed under the same test conditions. Herein we perform a quantitative and comparative evaluation of ten state-of-the-art methods for 3D-2D registration on a public dataset of clinical angiograms. Image database consisted of 3D and 2D angiograms of 25 patients undergoing treatment for cerebral aneurysms or arteriovenous malformations. On each of the datasets, highly accurate "gold-standard" registrations of 3D and 2D images were established based on patient-attached fiducial markers. The database was used to rigorously evaluate ten state-of-the-art 3D-2D registration methods, namely two intensity-, two gradient-, three feature-based and three hybrid methods, both for registration of 3D pre-interventional image to monoplane or biplane 2D images. Intensity-based methods were most accurate in all tests (0.3 mm). One of the hybrid methods was most robust with 98.75% of successful registrations (SR) and capture range of 18 mm for registrations of 3D to biplane 2D angiograms. In general, registration accuracy was similar whether registration of 3D image was performed onto mono- or biplanar 2D images; however, the SR was substantially lower in case of 3D to monoplane 2D registration. Two feature-based and two hybrid methods had clinically feasible execution times in the order of a second. Performance of methods seems to fall below expectations in terms of robustness in case of registration of 3D to monoplane 2D images, while translation into clinical image guidance systems seems readily feasible for methods that perform registration of the 3D pre-interventional image onto biplanar intra

Accelerated echo-planar J-resolved spectroscopic imaging in the human brain using compressed sensing: a pilot validation in obstructive sleep apnea.

Science.gov (United States)

Sarma, M K; Nagarajan, R; Macey, P M; Kumar, R; Villablanca, J P; Furuyama, J; Thomas, M A

2014-06-01

Echo-planar J-resolved spectroscopic imaging is a fast spectroscopic technique to record the biochemical information in multiple regions of the brain, but for clinical applications, time is still a constraint. Investigations of neural injury in obstructive sleep apnea have revealed structural changes in the brain, but determining the neurochemical changes requires more detailed measurements across multiple brain regions, demonstrating a need for faster echo-planar J-resolved spectroscopic imaging. Hence, we have extended the compressed sensing reconstruction of prospectively undersampled 4D echo-planar J-resolved spectroscopic imaging to investigate metabolic changes in multiple brain locations of patients with obstructive sleep apnea and healthy controls. Nonuniform undersampling was imposed along 1 spatial and 1 spectral dimension of 4D echo-planar J-resolved spectroscopic imaging, and test-retest reliability of the compressed sensing reconstruction of the nonuniform undersampling data was tested by using a brain phantom. In addition, 9 patients with obstructive sleep apnea and 11 healthy controls were investigated by using a 3T MR imaging/MR spectroscopy scanner. Significantly reduced metabolite differences were observed between patients with obstructive sleep apnea and healthy controls in multiple brain regions: NAA/Cr in the left hippocampus; total Cho/Cr and Glx/Cr in the right hippocampus; total NAA/Cr, taurine/Cr, scyllo-Inositol/Cr, phosphocholine/Cr, and total Cho/Cr in the occipital gray matter; total NAA/Cr and NAA/Cr in the medial frontal white matter; and taurine/Cr and total Cho/Cr in the left frontal white matter regions. The 4D echo-planar J-resolved spectroscopic imaging technique using the nonuniform undersampling-based acquisition and compressed sensing reconstruction in patients with obstructive sleep apnea and healthy brain is feasible in a clinically suitable time. In addition to brain metabolite changes previously reported by 1D MR

SU-D-BRA-03: Analysis of Systematic Errors with 2D/3D Image Registration for Target Localization and Treatment Delivery in Stereotactic Radiosurgery

International Nuclear Information System (INIS)

Xu, H; Chetty, I; Wen, N

2016-01-01

Purpose: Determine systematic deviations between 2D/3D and 3D/3D image registrations with six degrees of freedom (6DOF) for various imaging modalities and registration algorithms on the Varian Edge Linac. Methods: The 6DOF systematic errors were assessed by comparing automated 2D/3D (kV/MV vs. CT) with 3D/3D (CBCT vs. CT) image registrations from different imaging pairs, CT slice thicknesses, couch angles, similarity measures, etc., using a Rando head and a pelvic phantom. The 2D/3D image registration accuracy was evaluated at different treatment sites (intra-cranial and extra-cranial) by statistically analyzing 2D/3D pre-treatment verification against 3D/3D localization of 192 Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy treatment fractions for 88 patients. Results: The systematic errors of 2D/3D image registration using kV-kV, MV-kV and MV-MV image pairs using 0.8 mm slice thickness CT images were within 0.3 mm and 0.3° for translations and rotations with a 95% confidence interval (CI). No significant difference between 2D/3D and 3D/3D image registrations (P>0.05) was observed for target localization at various CT slice thicknesses ranging from 0.8 to 3 mm. Couch angles (30, 45, 60 degree) did not impact the accuracy of 2D/3D image registration. Using pattern intensity with content image filtering was recommended for 2D/3D image registration to achieve the best accuracy. For the patient study, translational error was within 2 mm and rotational error was within 0.6 degrees in terms of 95% CI for 2D/3D image registration. For intra-cranial sites, means and std. deviations of translational errors were −0.2±0.7, 0.04±0.5, 0.1±0.4 mm for LNG, LAT, VRT directions, respectively. For extra-cranial sites, means and std. deviations of translational errors were - 0.04±1, 0.2±1, 0.1±1 mm for LNG, LAT, VRT directions, respectively. 2D/3D image registration uncertainties for intra-cranial and extra-cranial sites were comparable. Conclusion: The Varian

SU-D-BRA-03: Analysis of Systematic Errors with 2D/3D Image Registration for Target Localization and Treatment Delivery in Stereotactic Radiosurgery

Energy Technology Data Exchange (ETDEWEB)

Xu, H [Wayne State University, Detroit, MI (United States); Chetty, I; Wen, N [Henry Ford Health System, Detroit, MI (United States)

2016-06-15

Purpose: Determine systematic deviations between 2D/3D and 3D/3D image registrations with six degrees of freedom (6DOF) for various imaging modalities and registration algorithms on the Varian Edge Linac. Methods: The 6DOF systematic errors were assessed by comparing automated 2D/3D (kV/MV vs. CT) with 3D/3D (CBCT vs. CT) image registrations from different imaging pairs, CT slice thicknesses, couch angles, similarity measures, etc., using a Rando head and a pelvic phantom. The 2D/3D image registration accuracy was evaluated at different treatment sites (intra-cranial and extra-cranial) by statistically analyzing 2D/3D pre-treatment verification against 3D/3D localization of 192 Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy treatment fractions for 88 patients. Results: The systematic errors of 2D/3D image registration using kV-kV, MV-kV and MV-MV image pairs using 0.8 mm slice thickness CT images were within 0.3 mm and 0.3° for translations and rotations with a 95% confidence interval (CI). No significant difference between 2D/3D and 3D/3D image registrations (P>0.05) was observed for target localization at various CT slice thicknesses ranging from 0.8 to 3 mm. Couch angles (30, 45, 60 degree) did not impact the accuracy of 2D/3D image registration. Using pattern intensity with content image filtering was recommended for 2D/3D image registration to achieve the best accuracy. For the patient study, translational error was within 2 mm and rotational error was within 0.6 degrees in terms of 95% CI for 2D/3D image registration. For intra-cranial sites, means and std. deviations of translational errors were −0.2±0.7, 0.04±0.5, 0.1±0.4 mm for LNG, LAT, VRT directions, respectively. For extra-cranial sites, means and std. deviations of translational errors were - 0.04±1, 0.2±1, 0.1±1 mm for LNG, LAT, VRT directions, respectively. 2D/3D image registration uncertainties for intra-cranial and extra-cranial sites were comparable. Conclusion: The Varian

Extracting 3D Parametric Curves from 2D Images of Helical Objects.

Science.gov (United States)

Willcocks, Chris G; Jackson, Philip T G; Nelson, Carl J; Obara, Boguslaw

2017-09-01

Helical objects occur in medicine, biology, cosmetics, nanotechnology, and engineering. Extracting a 3D parametric curve from a 2D image of a helical object has many practical applications, in particular being able to extract metrics such as tortuosity, frequency, and pitch. We present a method that is able to straighten the image object and derive a robust 3D helical curve from peaks in the object boundary. The algorithm has a small number of stable parameters that require little tuning, and the curve is validated against both synthetic and real-world data. The results show that the extracted 3D curve comes within close Hausdorff distance to the ground truth, and has near identical tortuosity for helical objects with a circular profile. Parameter insensitivity and robustness against high levels of image noise are demonstrated thoroughly and quantitatively.

Quantitative analysis of pulmonary perfusion using time-resolved parallel 3D MRI - initial results

International Nuclear Information System (INIS)

Fink, C.; Buhmann, R.; Plathow, C.; Puderbach, M.; Kauczor, H.U.; Risse, F.; Ley, S.; Meyer, F.J.

2004-01-01

Purpose: to assess the use of time-resolved parallel 3D MRI for a quantitative analysis of pulmonary perfusion in patients with cardiopulmonary disease. Materials and methods: eight patients with pulmonary embolism or pulmonary hypertension were examined with a time-resolved 3D gradient echo pulse sequence with parallel imaging techniques (FLASH 3D, TE/TR: 0.8/1.9 ms; flip angle: 40 ; GRAPPA). A quantitative perfusion analysis based on indicator dilution theory was performed using a dedicated software. Results: patients with pulmonary embolism or chronic thromboembolic pulmonary hypertension revealed characteristic wedge-shaped perfusion defects at perfusion MRI. They were characterized by a decreased pulmonary blood flow (PBF) and pulmonary blood volume (PBV) and increased mean transit time (MTT). Patients with primary pulmonary hypertension or eisenmenger syndrome showed a more homogeneous perfusion pattern. The mean MTT of all patients was 3.3 - 4.7 s. The mean PBF and PBV showed a broader interindividual variation (PBF: 104-322 ml/100 ml/min; PBV: 8 - 21 ml/100 ml). Conclusion: time-resolved parallel 3D MRI allows at least a semi-quantitative assessment of lung perfusion. Future studies will have to assess the clinical value of this quantitative information for the diagnosis and management of cardiopulmonary disease. (orig.) [de

FluoRender: An application of 2D image space methods for 3D and 4D confocal microscopy data visualization in neurobiology research

KAUST Repository

Wan, Yong; Otsuna, Hideo; Chien, Chi-Bin; Hansen, Charles

2012-01-01

2D image space methods are processing methods applied after the volumetric data are projected and rendered into the 2D image space, such as 2D filtering, tone mapping and compositing. In the application domain of volume visualization, most 2D image space methods can be carried out more efficiently than their 3D counterparts. Most importantly, 2D image space methods can be used to enhance volume visualization quality when applied together with volume rendering methods. In this paper, we present and discuss the applications of a series of 2D image space methods as enhancements to confocal microscopy visualizations, including 2D tone mapping, 2D compositing, and 2D color mapping. These methods are easily integrated with our existing confocal visualization tool, FluoRender, and the outcome is a full-featured visualization system that meets neurobiologists' demands for qualitative analysis of confocal microscopy data. © 2012 IEEE.

FluoRender: An application of 2D image space methods for 3D and 4D confocal microscopy data visualization in neurobiology research

KAUST Repository

Wan, Yong

2012-02-01

2D image space methods are processing methods applied after the volumetric data are projected and rendered into the 2D image space, such as 2D filtering, tone mapping and compositing. In the application domain of volume visualization, most 2D image space methods can be carried out more efficiently than their 3D counterparts. Most importantly, 2D image space methods can be used to enhance volume visualization quality when applied together with volume rendering methods. In this paper, we present and discuss the applications of a series of 2D image space methods as enhancements to confocal microscopy visualizations, including 2D tone mapping, 2D compositing, and 2D color mapping. These methods are easily integrated with our existing confocal visualization tool, FluoRender, and the outcome is a full-featured visualization system that meets neurobiologists\\' demands for qualitative analysis of confocal microscopy data. © 2012 IEEE.

Clinical evaluation of 2D versus 3D whole-body PET image quality using a dedicated BGO PET scanner

International Nuclear Information System (INIS)

Visvikis, D.; Griffiths, D.; Costa, D.C.; Bomanji, J.; Ell, P.J.

2005-01-01

Three-dimensional positron emission tomography (3D PET) results in higher system sensitivity, with an associated increase in the detection of scatter and random coincidences. The objective of this work was to compare, from a clinical perspective, 3D and two-dimensional (2D) acquisitions in terms of whole-body (WB) PET image quality with a dedicated BGO PET system. 2D and 3D WB emission acquisitions were carried out in 70 patients. Variable acquisition parameters in terms of time of emission acquisition per axial field of view (aFOV) and slice overlap between sequential aFOVs were used during the 3D acquisitions. 3D and 2D images were reconstructed using FORE+WLS and OSEM respectively. Scatter correction was performed by convolution subtraction and a model-based scatter correction in 2D and 3D respectively. All WB images were attenuation corrected using segmented transmission scans. Images were blindly assessed by three observers for the presence of artefacts, confidence in lesion detection and overall image quality using a scoring system. Statistically significant differences between 2D and 3D image quality were only obtained for 3D emission acquisitions of 3 min. No statistically significant differences were observed for image artefacts or lesion detectability scores. Image quality correlated significantly with patient weight for both modes of operation. Finally, no differences were seen in image artefact scores for the different axial slice overlaps considered, suggesting the use of five slice overlaps in 3D WB acquisitions. 3D WB imaging using a dedicated BGO-based PET scanner offers similar image quality to that obtained in 2D considering similar overall times of acquisitions. (orig.)

Registration of 2D C-Arm and 3D CT Images for a C-Arm Image-Assisted Navigation System for Spinal Surgery

Directory of Open Access Journals (Sweden)

Chih-Ju Chang

2015-01-01

Full Text Available C-Arm image-assisted surgical navigation system has been broadly applied to spinal surgery. However, accurate path planning on the C-Arm AP-view image is difficult. This research studies 2D-3D image registration methods to obtain the optimum transformation matrix between C-Arm and CT image frames. Through the transformation matrix, the surgical path planned on preoperative CT images can be transformed and displayed on the C-Arm images for surgical guidance. The positions of surgical instruments will also be displayed on both CT and C-Arm in the real time. Five similarity measure methods of 2D-3D image registration including Normalized Cross-Correlation, Gradient Correlation, Pattern Intensity, Gradient Difference Correlation, and Mutual Information combined with three optimization methods including Powell’s method, Downhill simplex algorithm, and genetic algorithm are applied to evaluate their performance in converge range, efficiency, and accuracy. Experimental results show that the combination of Normalized Cross-Correlation measure method with Downhill simplex algorithm obtains maximum correlation and similarity in C-Arm and Digital Reconstructed Radiograph (DRR images. Spine saw bones are used in the experiment to evaluate 2D-3D image registration accuracy. The average error in displacement is 0.22 mm. The success rate is approximately 90% and average registration time takes 16 seconds.

Motion robust high resolution 3D free-breathing pulmonary MRI using dynamic 3D image self-navigator.

Science.gov (United States)

Jiang, Wenwen; Ong, Frank; Johnson, Kevin M; Nagle, Scott K; Hope, Thomas A; Lustig, Michael; Larson, Peder E Z

2018-06-01

To achieve motion robust high resolution 3D free-breathing pulmonary MRI utilizing a novel dynamic 3D image navigator derived directly from imaging data. Five-minute free-breathing scans were acquired with a 3D ultrashort echo time (UTE) sequence with 1.25 mm isotropic resolution. From this data, dynamic 3D self-navigating images were reconstructed under locally low rank (LLR) constraints and used for motion compensation with one of two methods: a soft-gating technique to penalize the respiratory motion induced data inconsistency, and a respiratory motion-resolved technique to provide images of all respiratory motion states. Respiratory motion estimation derived from the proposed dynamic 3D self-navigator of 7.5 mm isotropic reconstruction resolution and a temporal resolution of 300 ms was successful for estimating complex respiratory motion patterns. This estimation improved image quality compared to respiratory belt and DC-based navigators. Respiratory motion compensation with soft-gating and respiratory motion-resolved techniques provided good image quality from highly undersampled data in volunteers and clinical patients. An optimized 3D UTE sequence combined with the proposed reconstruction methods can provide high-resolution motion robust pulmonary MRI. Feasibility was shown in patients who had irregular breathing patterns in which our approach could depict clinically relevant pulmonary pathologies. Magn Reson Med 79:2954-2967, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

Curvilinear 3-D Imaging Using Row--Column-Addressed 2-D Arrays with a Diverging Lens: Feasibility Study

DEFF Research Database (Denmark)

Bouzari, Hamed; Engholm, Mathias; Beers, Christopher

2017-01-01

imaging. Extended FOV and low channel count of double-curved RCA 2-D arrays make 3-D imaging possible with equipment in the price range of conventional 2-D imaging. This study proposes a delay-and-sum beamformation scheme specific to double-curved RCA 2-D arrays and validates its focusing ability based...... of this study demonstrate that the proposed beamforming approach is accurate for achieving correct time-of-flight calculations, and hence avoids geometrical distortions....

Free digital image analysis software helps to resolve equivocal scores in HER2 immunohistochemistry.

Science.gov (United States)

Helin, Henrik O; Tuominen, Vilppu J; Ylinen, Onni; Helin, Heikki J; Isola, Jorma

2016-02-01

Evaluation of human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) is subject to interobserver variation and lack of reproducibility. Digital image analysis (DIA) has been shown to improve the consistency and accuracy of the evaluation and its use is encouraged in current testing guidelines. We studied whether digital image analysis using a free software application (ImmunoMembrane) can assist in interpreting HER2 IHC in equivocal 2+ cases. We also compared digital photomicrographs with whole-slide images (WSI) as material for ImmunoMembrane DIA. We stained 750 surgical resection specimens of invasive breast cancers immunohistochemically for HER2 and analysed staining with ImmunoMembrane. The ImmunoMembrane DIA scores were compared with the originally responsible pathologists' visual scores, a researcher's visual scores and in situ hybridisation (ISH) results. The originally responsible pathologists reported 9.1 % positive 3+ IHC scores, for the researcher this was 8.4 % and for ImmunoMembrane 9.5 %. Equivocal 2+ scores were 34 % for the pathologists, 43.7 % for the researcher and 10.1 % for ImmunoMembrane. Negative 0/1+ scores were 57.6 % for the pathologists, 46.8 % for the researcher and 80.8 % for ImmunoMembrane. There were six false positive cases, which were classified as 3+ by ImmunoMembrane and negative by ISH. Six cases were false negative defined as 0/1+ by IHC and positive by ISH. ImmunoMembrane DIA using digital photomicrographs and WSI showed almost perfect agreement. In conclusion, digital image analysis by ImmunoMembrane can help to resolve a majority of equivocal 2+ cases in HER2 IHC, which reduces the need for ISH testing.

Contrast-enhanced MR angiography of the carotid artery using 3D time-resolved imaging of contrast kinetics. Comparison with real-time fluoroscopic triggered 3D-elliptical centric view ordering

International Nuclear Information System (INIS)

Naganawa, Shinji; Koshikawa, Tokiko; Fukatsu, Hiroshi; Sakurai, Yasuo; Ishiguchi, Tsuneo; Ishigaki, Takeo; Ichinose, Nobuyasu

2001-01-01

The purpose of this study was to evaluate contrast-enhanced MR angiography using the 3D time-resolved imaging of contrast kinetics technique (3D-TRICKS) by direct comparison with the fluoroscopic triggered 3D-elliptical centric view ordering (3D-ELLIP) technique. 3D-TRICKS and 3D-ELLIP were directly compared on a 1.5-Tesla MR unit using the same spatial resolution and matrix. In 3D-TRICKS, the central part of the k-space is updated more frequently than the peripheral part of the k-space, which is divided in the slice-encoding direction. The carotid arteries were imaged using 3D-TRICKS and 3D-ELLIP sequentially in 14 patients. Temporal resolution was 12 sec for 3D-ELLIP and 6 sec for 3D-TRICKS. The signal-to-noise ratio (S/N) of the common carotid artery was measured, and the quality of MIP images was then scored in terms of venous overlap and blurring of vessel contours. No significant difference in mean S/N was seen between the two methods. Significant venous overlap was not seen in any of the patients examined. Moderate blurring of vessel contours was noted on 3D-TRICKS in five patients and on 3D-ELLIP in four patients. Blurring in the slice-encoding direction was slightly more pronounced in 3D-TRICKS. However, qualitative analysis scores showed no significant differences. When the spatial resolution of the two methods was identical, the performance of 3D-TRICKS was found to be comparable in static visualization of the carotid arteries with 3D-ELLIP, although blurring in the slice-encoding direction was slightly more pronounced in 3D-TRICKS. 3D-TRICKS is a more robust technique than 3D-ELLIP, because 3D-ELLIP requires operator-dependent fluoroscopic triggering. Furthermore, 3D-TRICKS can achieve higher temporal resolution. For the spatial resolution employed in this study, 3D-TRICKS may be the method of choice. (author)

Fast segmentation of stained nuclei in terabyte-scale, time resolved 3D microscopy image stacks.

Directory of Open Access Journals (Sweden)

Johannes Stegmaier

Full Text Available Automated analysis of multi-dimensional microscopy images has become an integral part of modern research in life science. Most available algorithms that provide sufficient segmentation quality, however, are infeasible for a large amount of data due to their high complexity. In this contribution we present a fast parallelized segmentation method that is especially suited for the extraction of stained nuclei from microscopy images, e.g., of developing zebrafish embryos. The idea is to transform the input image based on gradient and normal directions in the proximity of detected seed points such that it can be handled by straightforward global thresholding like Otsu's method. We evaluate the quality of the obtained segmentation results on a set of real and simulated benchmark images in 2D and 3D and show the algorithm's superior performance compared to other state-of-the-art algorithms. We achieve an up to ten-fold decrease in processing times, allowing us to process large data sets while still providing reasonable segmentation results.

Precipitation Processes developed during ARM (1997), TOGA COARE (1992), GATE (1974), SCSMEX (1998), and KWAJEX (1999), Consistent 2D, semi-3D and 3D Cloud Resolving Model Simulations

Science.gov (United States)

Tao, Wei-Kuo; Hou, A.; Atlas, R.; Starr, D.; Sud, Y.

2003-01-01

Real clouds and cloud systems are inherently three-dimensional (3D). Because of the limitations in computer resources, however, most cloud-resolving models (CRMs) today are still two-dimensional (2D). A few 3D CRMs have been used to study the response of clouds to large-scale forcing. In these 3D simulations, the model domain was small, and the integration time was 6 hours. The major objectives of this paper are: (1) to assess the performance of the super-parameterization technique (i.e. is 2D or semi-3D CRM appropriate for the super-parameterization?); (2) calculate and examine the surface energy (especially radiation) and water budgets; (3) identify the differences and similarities in the organization and entrainment rates of convection between simulated 2D and 3D cloud systems.

Real-time 3D imaging methods using 2D phased arrays based on synthetic focusing techniques.

Science.gov (United States)

Kim, Jung-Jun; Song, Tai-Kyong

2008-07-01

A fast 3D ultrasound imaging technique using a 2D phased array transducer based on the synthetic focusing method for nondestructive testing or medical imaging is proposed. In the proposed method, each column of a 2D array is fired successively to produce transverse fan beams focused at a fixed depth along a given longitudinal direction and the resulting pulse echoes are received at all elements of a 2D array used. After firing all column arrays, a frame of high-resolution image along a given longitudinal direction is obtained with dynamic focusing employed in the longitudinal direction on receive and in the transverse direction on both transmit and receive. The volume rate of the proposed method can be increased much higher than that of the conventional 2D array imaging by employing an efficient sparse array technique. A simple modification to the proposed method can further increase the volume scan rate significantly. The proposed methods are verified through computer simulations.

Head pose estimation from a 2D face image using 3D face morphing with depth parameters.

Science.gov (United States)

Kong, Seong G; Mbouna, Ralph Oyini

2015-06-01

This paper presents estimation of head pose angles from a single 2D face image using a 3D face model morphed from a reference face model. A reference model refers to a 3D face of a person of the same ethnicity and gender as the query subject. The proposed scheme minimizes the disparity between the two sets of prominent facial features on the query face image and the corresponding points on the 3D face model to estimate the head pose angles. The 3D face model used is morphed from a reference model to be more specific to the query face in terms of the depth error at the feature points. The morphing process produces a 3D face model more specific to the query image when multiple 2D face images of the query subject are available for training. The proposed morphing process is computationally efficient since the depth of a 3D face model is adjusted by a scalar depth parameter at feature points. Optimal depth parameters are found by minimizing the disparity between the 2D features of the query face image and the corresponding features on the morphed 3D model projected onto 2D space. The proposed head pose estimation technique was evaluated on two benchmarking databases: 1) the USF Human-ID database for depth estimation and 2) the Pointing'04 database for head pose estimation. Experiment results demonstrate that head pose estimation errors in nodding and shaking angles are as low as 7.93° and 4.65° on average for a single 2D input face image.

Clinical performance of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced pediatric abdominal MR angiography.

Science.gov (United States)

Zhang, Tao; Yousaf, Ufra; Hsiao, Albert; Cheng, Joseph Y; Alley, Marcus T; Lustig, Michael; Pauly, John M; Vasanawala, Shreyas S

2015-10-01

Pediatric contrast-enhanced MR angiography is often limited by respiration, other patient motion and compromised spatiotemporal resolution. To determine the reliability of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography method for depicting abdominal arterial anatomy in young children. With IRB approval and informed consent, we retrospectively identified 27 consecutive children (16 males and 11 females; mean age: 3.8 years, range: 14 days to 8.4 years) referred for contrast-enhanced MR angiography at our institution, who had undergone free-breathing spatiotemporally accelerated time-resolved contrast-enhanced MR angiography studies. A radio-frequency-spoiled gradient echo sequence with Cartesian variable density k-space sampling and radial view ordering, intrinsic motion navigation and intermittent fat suppression was developed. Images were reconstructed with soft-gated parallel imaging locally low-rank method to achieve both motion correction and high spatiotemporal resolution. Quality of delineation of 13 abdominal arteries in the reconstructed images was assessed independently by two radiologists on a five-point scale. Ninety-five percent confidence intervals of the proportion of diagnostically adequate cases were calculated. Interobserver agreements were also analyzed. Eleven out of 13 arteries achieved acceptable image quality (mean score range: 3.9-5.0) for both readers. Fair to substantial interobserver agreement was reached on nine arteries. Free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography frequently yields diagnostic image quality for most abdominal arteries in young children.

Clinical performance of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced pediatric abdominal MR angiography

Energy Technology Data Exchange (ETDEWEB)

Zhang, Tao; Cheng, Joseph Y. [Stanford University, Department of Radiology, Stanford, CA (United States); Stanford University, Department of Electrical Engineering, Stanford, CA (United States); Yousaf, Ufra; Alley, Marcus T.; Vasanawala, Shreyas S. [Stanford University, Department of Radiology, Stanford, CA (United States); Hsiao, Albert [University of California, San Diego, Department of Radiology, San Diego, CA (United States); Lustig, Michael [Stanford University, Department of Electrical Engineering, Stanford, CA (United States); University of California, Berkeley, Department of Electrical Engineering and Computer Sciences, Berkeley, CA (United States); Pauly, John M. [Stanford University, Department of Electrical Engineering, Stanford, CA (United States)

2015-10-15

Pediatric contrast-enhanced MR angiography is often limited by respiration, other patient motion and compromised spatiotemporal resolution. To determine the reliability of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography method for depicting abdominal arterial anatomy in young children. With IRB approval and informed consent, we retrospectively identified 27 consecutive children (16 males and 11 females; mean age: 3.8 years, range: 14 days to 8.4 years) referred for contrast-enhanced MR angiography at our institution, who had undergone free-breathing spatiotemporally accelerated time-resolved contrast-enhanced MR angiography studies. A radio-frequency-spoiled gradient echo sequence with Cartesian variable density k-space sampling and radial view ordering, intrinsic motion navigation and intermittent fat suppression was developed. Images were reconstructed with soft-gated parallel imaging locally low-rank method to achieve both motion correction and high spatiotemporal resolution. Quality of delineation of 13 abdominal arteries in the reconstructed images was assessed independently by two radiologists on a five-point scale. Ninety-five percent confidence intervals of the proportion of diagnostically adequate cases were calculated. Interobserver agreements were also analyzed. Eleven out of 13 arteries achieved acceptable image quality (mean score range: 3.9-5.0) for both readers. Fair to substantial interobserver agreement was reached on nine arteries. Free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography frequently yields diagnostic image quality for most abdominal arteries in young children. (orig.)

Clinical performance of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced pediatric abdominal MR angiography

International Nuclear Information System (INIS)

Zhang, Tao; Cheng, Joseph Y.; Yousaf, Ufra; Alley, Marcus T.; Vasanawala, Shreyas S.; Hsiao, Albert; Lustig, Michael; Pauly, John M.

2015-01-01

Pediatric contrast-enhanced MR angiography is often limited by respiration, other patient motion and compromised spatiotemporal resolution. To determine the reliability of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography method for depicting abdominal arterial anatomy in young children. With IRB approval and informed consent, we retrospectively identified 27 consecutive children (16 males and 11 females; mean age: 3.8 years, range: 14 days to 8.4 years) referred for contrast-enhanced MR angiography at our institution, who had undergone free-breathing spatiotemporally accelerated time-resolved contrast-enhanced MR angiography studies. A radio-frequency-spoiled gradient echo sequence with Cartesian variable density k-space sampling and radial view ordering, intrinsic motion navigation and intermittent fat suppression was developed. Images were reconstructed with soft-gated parallel imaging locally low-rank method to achieve both motion correction and high spatiotemporal resolution. Quality of delineation of 13 abdominal arteries in the reconstructed images was assessed independently by two radiologists on a five-point scale. Ninety-five percent confidence intervals of the proportion of diagnostically adequate cases were calculated. Interobserver agreements were also analyzed. Eleven out of 13 arteries achieved acceptable image quality (mean score range: 3.9-5.0) for both readers. Fair to substantial interobserver agreement was reached on nine arteries. Free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography frequently yields diagnostic image quality for most abdominal arteries in young children. (orig.)

Atom-resolved AFM imaging of calcite nanoparticles in water

Energy Technology Data Exchange (ETDEWEB)

Imada, Hirotake; Kimura, Kenjiro [Department of Chemistry, School of Science, Kobe University, Rokko-dai, Nada, Kobe 657-8501 (Japan); Onishi, Hiroshi, E-mail: oni@kobe-u.ac.jp [Department of Chemistry, School of Science, Kobe University, Rokko-dai, Nada, Kobe 657-8501 (Japan)

2013-06-20

Highlights: ► An advanced frequency-modulation AFM (FM-AFM) was applied for imaging particles. ► Atom-resolved topography of nano-sized particles of calcite was observed in water. ► Locally ordered structures were found and assigned to a (104) facet of calcite. ► A promising ability of FM-AFM was demonstrated in imaging nano-sized particles. - Abstract: The atom-resolved topography of calcite nanoparticles was observed in water using a frequency-modulation atomic force microscope. Locally ordered structures were found and assigned to a (104) facet of crystalline calcite.

Atom-resolved AFM imaging of calcite nanoparticles in water

International Nuclear Information System (INIS)

Imada, Hirotake; Kimura, Kenjiro; Onishi, Hiroshi

2013-01-01

Highlights: ► An advanced frequency-modulation AFM (FM-AFM) was applied for imaging particles. ► Atom-resolved topography of nano-sized particles of calcite was observed in water. ► Locally ordered structures were found and assigned to a (104) facet of calcite. ► A promising ability of FM-AFM was demonstrated in imaging nano-sized particles. - Abstract: The atom-resolved topography of calcite nanoparticles was observed in water using a frequency-modulation atomic force microscope. Locally ordered structures were found and assigned to a (104) facet of crystalline calcite

MLESAC Based Localization of Needle Insertion Using 2D Ultrasound Images

Science.gov (United States)

Xu, Fei; Gao, Dedong; Wang, Shan; Zhanwen, A.

2018-04-01

In the 2D ultrasound image of ultrasound-guided percutaneous needle insertions, it is difficult to determine the positions of needle axis and tip because of the existence of artifacts and other noises. In this work the speckle is regarded as the noise of an ultrasound image, and a novel algorithm is presented to detect the needle in a 2D ultrasound image. Firstly, the wavelet soft thresholding technique based on BayesShrink rule is used to denoise the speckle of ultrasound image. Secondly, we add Otsu’s thresholding method and morphologic operations to pre-process the ultrasound image. Finally, the localization of the needle is identified and positioned in the 2D ultrasound image based on the maximum likelihood estimation sample consensus (MLESAC) algorithm. The experimental results show that it is valid for estimating the position of needle axis and tip in the ultrasound images with the proposed algorithm. The research work is hopeful to be used in the path planning and robot-assisted needle insertion procedures.

Testing the resolving power of 2-D K+ K+ interferometry at Ags energies

International Nuclear Information System (INIS)

Roldao, Cristiane G.; Padula, Sandra S.

1998-01-01

Adopting a procedure previously proposed to quantitatively study pion interferometry, an equivalent 2-D X 2 analysis was performed to test the resolving power of that method when applied to less favorable conditions, i.e., when non significant contribution from long lived resonances is expected, as in kaon interferometry. For that purpose, use is made of the preliminary E859 K + K + interferometry data from Si+Au collisions at 14.6 A GeV/c. Less sensitivity is achieved in the present case, although it is shown that it is still possible to distinguish two distinct decoupling geometries. The possible compatibility of the data with zero decoupling proper time interval, suggested by the experimental fit, is also investigated and seems to be ruled out when considering dynamical models with expanding sources. (author)

Toward 2D and 3D imaging of magnetic nanoparticles using EPR measurements.

Science.gov (United States)

Coene, A; Crevecoeur, G; Leliaert, J; Dupré, L

2015-09-01

Magnetic nanoparticles (MNPs) are an important asset in many biomedical applications. An effective working of these applications requires an accurate knowledge of the spatial MNP distribution. A promising, noninvasive, and sensitive technique to visualize MNP distributions in vivo is electron paramagnetic resonance (EPR). Currently only 1D MNP distributions can be reconstructed. In this paper, the authors propose extending 1D EPR toward 2D and 3D using computer simulations to allow accurate imaging of MNP distributions. To find the MNP distribution belonging to EPR measurements, an inverse problem needs to be solved. The solution of this inverse problem highly depends on the stability of the inverse problem. The authors adapt 1D EPR imaging to realize the imaging of multidimensional MNP distributions. Furthermore, the authors introduce partial volume excitation in which only parts of the volume are imaged to increase stability of the inverse solution and to speed up the measurements. The authors simulate EPR measurements of different 2D and 3D MNP distributions and solve the inverse problem. The stability is evaluated by calculating the condition measure and by comparing the actual MNP distribution to the reconstructed MNP distribution. Based on these simulations, the authors define requirements for the EPR system to cope with the added dimensions. Moreover, the authors investigate how EPR measurements should be conducted to improve the stability of the associated inverse problem and to increase reconstruction quality. The approach used in 1D EPR can only be employed for the reconstruction of small volumes in 2D and 3D EPRs due to numerical instability of the inverse solution. The authors performed EPR measurements of increasing cylindrical volumes and evaluated the condition measure. This showed that a reduction of the inherent symmetry in the EPR methodology is necessary. By reducing the symmetry of the EPR setup, quantitative images of larger volumes can be

Toward 2D and 3D imaging of magnetic nanoparticles using EPR measurements

International Nuclear Information System (INIS)

Coene, A.; Crevecoeur, G.; Dupré, L.; Leliaert, J.

2015-01-01

Purpose: Magnetic nanoparticles (MNPs) are an important asset in many biomedical applications. An effective working of these applications requires an accurate knowledge of the spatial MNP distribution. A promising, noninvasive, and sensitive technique to visualize MNP distributions in vivo is electron paramagnetic resonance (EPR). Currently only 1D MNP distributions can be reconstructed. In this paper, the authors propose extending 1D EPR toward 2D and 3D using computer simulations to allow accurate imaging of MNP distributions. Methods: To find the MNP distribution belonging to EPR measurements, an inverse problem needs to be solved. The solution of this inverse problem highly depends on the stability of the inverse problem. The authors adapt 1D EPR imaging to realize the imaging of multidimensional MNP distributions. Furthermore, the authors introduce partial volume excitation in which only parts of the volume are imaged to increase stability of the inverse solution and to speed up the measurements. The authors simulate EPR measurements of different 2D and 3D MNP distributions and solve the inverse problem. The stability is evaluated by calculating the condition measure and by comparing the actual MNP distribution to the reconstructed MNP distribution. Based on these simulations, the authors define requirements for the EPR system to cope with the added dimensions. Moreover, the authors investigate how EPR measurements should be conducted to improve the stability of the associated inverse problem and to increase reconstruction quality. Results: The approach used in 1D EPR can only be employed for the reconstruction of small volumes in 2D and 3D EPRs due to numerical instability of the inverse solution. The authors performed EPR measurements of increasing cylindrical volumes and evaluated the condition measure. This showed that a reduction of the inherent symmetry in the EPR methodology is necessary. By reducing the symmetry of the EPR setup, quantitative images of

Measurable realistic image-based 3D mapping

Science.gov (United States)

Liu, W.; Wang, J.; Wang, J. J.; Ding, W.; Almagbile, A.

2011-12-01

Maps with 3D visual models are becoming a remarkable feature of 3D map services. High-resolution image data is obtained for the construction of 3D visualized models.The3D map not only provides the capabilities of 3D measurements and knowledge mining, but also provides the virtual experienceof places of interest, such as demonstrated in the Google Earth. Applications of 3D maps are expanding into the areas of architecture, property management, and urban environment monitoring. However, the reconstruction of high quality 3D models is time consuming, and requires robust hardware and powerful software to handle the enormous amount of data. This is especially for automatic implementation of 3D models and the representation of complicated surfacesthat still need improvements with in the visualisation techniques. The shortcoming of 3D model-based maps is the limitation of detailed coverage since a user can only view and measure objects that are already modelled in the virtual environment. This paper proposes and demonstrates a 3D map concept that is realistic and image-based, that enables geometric measurements and geo-location services. Additionally, image-based 3D maps provide more detailed information of the real world than 3D model-based maps. The image-based 3D maps use geo-referenced stereo images or panoramic images. The geometric relationships between objects in the images can be resolved from the geometric model of stereo images. The panoramic function makes 3D maps more interactive with users but also creates an interesting immersive circumstance. Actually, unmeasurable image-based 3D maps already exist, such as Google street view, but only provide virtual experiences in terms of photos. The topographic and terrain attributes, such as shapes and heights though are omitted. This paper also discusses the potential for using a low cost land Mobile Mapping System (MMS) to implement realistic image 3D mapping, and evaluates the positioning accuracy that a measureable

State resolved rotational excitation in HD+D2 collisions. II. Angular dependence of 0→2 transitions

International Nuclear Information System (INIS)

Buck, U.; Huisken, F.; Maneke, G.; Schaefer, J.

1983-01-01

Time-of-flight spectra for the scattering of HD molecules from D 2 molecules have been measured at a collision energy of E = 70.3 meV over a range of center-of-mass scattering angles from 45 0 to 158 0 . The spectra reveal clearly resolved transitions at the energy loss ΔE = 33 meV which corresponds to 0→2 transitions of HD and the double transition 0→1 of HD and 0→2 of D 2 . The differential cross sections derived from these spectra increase with increasing scattering angle from 1.7% to 34.7% of the elastic cross section. The pure 0→2 transition of D 2 which only needs 22 meV to be induced could not be detected within our experimental sensitivity of 0.02 A 2 /sr. Closed coupled calculations based on the ab initio potential surface of Meyer and Schaefer show that this result can be explained by the different coupling terms which are responsible for these transitions. In contrast to the 0→1 transition the 0→2 transition of HD proved to be sensitive to the anisotropic part of the interaction potential for the homonuclear system. The comparison of experimental and calculated cross sections for the ab initio potential of Meyer and Schaefer reveals discrepancies for the 0→1 transition of HD, but shows agreement for the 0→2 transition of HD at intermediate angles

Efficient 2-D DCT Computation from an Image Representation Point of View

OpenAIRE

Papakostas, G.A.; Koulouriotis, D.E.; Karakasis, E.G.

2009-01-01

A novel methodology that ensures the computation of 2-D DCT coefficients in gray-scale images as well as in binary ones, with high computation rates, was presented in the previous sections. Through a new image representation scheme, called ISR (Image Slice Representation) the 2-D DCT coefficients can be computed in significantly reduced time, with the same accuracy.

Color image enhancement of medical images using alpha-rooting and zonal alpha-rooting methods on 2D QDFT

Science.gov (United States)

Grigoryan, Artyom M.; John, Aparna; Agaian, Sos S.

2017-03-01

2-D quaternion discrete Fourier transform (2-D QDFT) is the Fourier transform applied to color images when the color images are considered in the quaternion space. The quaternion numbers are four dimensional hyper-complex numbers. Quaternion representation of color image allows us to see the color of the image as a single unit. In quaternion approach of color image enhancement, each color is seen as a vector. This permits us to see the merging effect of the color due to the combination of the primary colors. The color images are used to be processed by applying the respective algorithm onto each channels separately, and then, composing the color image from the processed channels. In this article, the alpha-rooting and zonal alpha-rooting methods are used with the 2-D QDFT. In the alpha-rooting method, the alpha-root of the transformed frequency values of the 2-D QDFT are determined before taking the inverse transform. In the zonal alpha-rooting method, the frequency spectrum of the 2-D QDFT is divided by different zones and the alpha-rooting is applied with different alpha values for different zones. The optimization of the choice of alpha values is done with the genetic algorithm. The visual perception of 3-D medical images is increased by changing the reference gray line.

124I-Epidepride: A PET radiotracer for extended imaging of dopamine D2/D3 receptors

International Nuclear Information System (INIS)

Pandey, Suresh; Venugopal, Archana; Kant, Ritu; Coleman, Robert; Mukherjee, Jogeshwar

2014-01-01

Objectives: A new radiotracer, 124 I-epidepride, has been developed for the imaging of dopamine D2/3 receptors (D2/3Rs). 124 I-Epidepride (half-life of 124 I = 4.2 days) allows imaging over extended periods compared to 18 F-fallypride (half-life of 18 F = 0.076 days) and may maximize visualization of D2/3Rs in the brain and pancreas (allowing clearance from adjacent organs). D2/3Rs are also present in pancreatic islets where they co-localize with insulin to produce granules and may serve as a surrogate marker for imaging diabetes. Methods: 124 I-Epidepride was synthesized using N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5-tributyltin-2, 3-dimethoxybenzamide and 124 I-iodide under no carrier added condition. Rats were used for in vitro and in vivo imaging. Brain slices were incubated with 124 I-epidepride (0.75 μCi/cc) and nonspecific binding measured with 10 μM haloperidol. Autoradiograms were analyzed by OptiQuant. 124 I-Epidepride (0.2 to 0.3 mCi, iv) was administered to rats and brain uptake at 3 hours, 24 hours, and 48 hours post injection was evaluated. Results: 124 I-Epidepride was obtained with 50% radiochemical yield and high radiochemical purity (> 95%). 124 I-Epidepride localized in the striatum with a striatum to cerebellum ratio of 10. Binding was displaced by dopamine and haloperidol. Brain slices demonstrated localization of 124 I-epidepride up until 48 hours in the striatum. However, the extent of binding was reduced significantly. Conclusions: 124 I-Epidepride is a new radiotracer suitable for extended imaging of dopamine D2/3 receptors and may have applications in imaging of receptors in the brain and monitoring pancreatic islet cell grafting

Sampling Number Effects in 2D and Range Imaging of Range-gated Acquisition

International Nuclear Information System (INIS)

Kwon, Seong-Ouk; Park, Seung-Kyu; Baik, Sung-Hoon; Cho, Jai-Wan; Jeong, Kyung-Min

2015-01-01

In this paper, we analyzed the number effects of sampling images for making a 2D image and a range image from acquired RGI images. We analyzed the number effects of RGI images for making a 2D image and a range image using a RGI vision system. As the results, 2D image quality was not much depended on the number of sampling images but on how much well extract efficient RGI images. But, the number of RGI images was important for making a range image because range image quality was proportional to the number of RGI images. Image acquiring in a monitoring area of nuclear industry is an important function for safety inspection and preparing appropriate control plans. To overcome the non-visualization problem caused by airborne obstacle particles, vision systems should have extra-functions, such as active illumination lightening through disturbance airborne particles. One of these powerful active vision systems is a range-gated imaging system. The vision system based on the range-gated imaging system can acquire image data from raining or smoking environments. Range-gated imaging (RGI) is a direct active visualization technique using a highly sensitive image sensor and a high intensity illuminant. Currently, the range-gated imaging technique providing 2D and 3D images is one of emerging active vision technologies. The range-gated imaging system gets vision information by summing time sliced vision images. In the RGI system, a high intensity illuminant illuminates for ultra-short time and a highly sensitive image sensor is gated by ultra-short exposure time to only get the illumination light. Here, the illuminant illuminates objects by flashing strong light through airborne disturbance particles. Thus, in contrast to passive conventional vision systems, the RGI active vision technology robust for low-visibility environments

Sampling Number Effects in 2D and Range Imaging of Range-gated Acquisition

Energy Technology Data Exchange (ETDEWEB)

Kwon, Seong-Ouk; Park, Seung-Kyu; Baik, Sung-Hoon; Cho, Jai-Wan; Jeong, Kyung-Min [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-10-15

In this paper, we analyzed the number effects of sampling images for making a 2D image and a range image from acquired RGI images. We analyzed the number effects of RGI images for making a 2D image and a range image using a RGI vision system. As the results, 2D image quality was not much depended on the number of sampling images but on how much well extract efficient RGI images. But, the number of RGI images was important for making a range image because range image quality was proportional to the number of RGI images. Image acquiring in a monitoring area of nuclear industry is an important function for safety inspection and preparing appropriate control plans. To overcome the non-visualization problem caused by airborne obstacle particles, vision systems should have extra-functions, such as active illumination lightening through disturbance airborne particles. One of these powerful active vision systems is a range-gated imaging system. The vision system based on the range-gated imaging system can acquire image data from raining or smoking environments. Range-gated imaging (RGI) is a direct active visualization technique using a highly sensitive image sensor and a high intensity illuminant. Currently, the range-gated imaging technique providing 2D and 3D images is one of emerging active vision technologies. The range-gated imaging system gets vision information by summing time sliced vision images. In the RGI system, a high intensity illuminant illuminates for ultra-short time and a highly sensitive image sensor is gated by ultra-short exposure time to only get the illumination light. Here, the illuminant illuminates objects by flashing strong light through airborne disturbance particles. Thus, in contrast to passive conventional vision systems, the RGI active vision technology robust for low-visibility environments.

Triple-color super-resolution imaging of live cells: resolving submicroscopic receptor organization in the plasma membrane.

Science.gov (United States)

Wilmes, Stephan; Staufenbiel, Markus; Lisse, Domenik; Richter, Christian P; Beutel, Oliver; Busch, Karin B; Hess, Samuel T; Piehler, Jacob

2012-05-14

In living color: efficient intracellular covalent labeling of proteins with a photoswitchable dye using the HaloTag for dSTORM super-resolution imaging in live cells is described. The dynamics of cellular nanostructures at the plasma membrane were monitored with a time resolution of a few seconds. In combination with dual-color FPALM imaging, submicroscopic receptor organization within the context of the membrane skeleton was resolved. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Algebraic 2D PET image reconstruction using depth-of-interaction information

International Nuclear Information System (INIS)

Yamaya, Taiga; Obi, Takashi; Yamaguchi, Masahiro; Kita, Kouichi

2001-01-01

Recently a high-performance PET scanner, which measures depth-of-interaction (DOI) information, is being developed for molecular imaging. DOI measurement of multi-layered thin crystals can improve spatial resolution and scanner sensitivity simultaneously. In this paper, we apply an algebraic image reconstruction method to 2-dimensional (2D) DOI-PET scanners using accurate system modeling, in order to evaluate the effects of using DOI information on PET image quality. Algebraic image reconstruction methods have been successfully used to improve PET image quality, compared with the conventional filtered backprojection method. The proposed method is applied to simulated data for a small 2D DOI-PET scanner. The results show that accurate system modeling improves spatial resolution without noise emphasis, and that DOI information improves uniformity of spatial resolution. (author)

Buried Man-made Structure Imaging using 2-D Resistivity Inversion

Science.gov (United States)

Anderson Bery, Andy; Nordiana, M. M.; El Hidayah Ismail, Noer; Jinmin, M.; Nur Amalina, M. K. A.

2018-04-01

This study is carried out with the objective to determine the suitable resistivity inversion method for buried man-made structure (bunker). This study was carried out with two stages. The first stage is suitable array determination using 2-D computerized modeling method. One suitable array is used for the infield resistivity survey to determine the dimension and location of the target. The 2-D resistivity inversion results showed that robust inversion method is suitable to resolve the top and bottom part of the buried bunker as target. In addition, the dimension of the buried bunker is successfully determined with height of 7 m and length of 20 m. The location of this target is located at -10 m until 10 m of the infield resistivity survey line. The 2-D resistivity inversion results obtained in this study showed that the parameters selection is important in order to give the optimum results. These parameters are array type, survey geometry and inversion method used in data processing.

Time-resolved 3D pulmonary perfusion MRI: comparison of different k-space acquisition strategies at 1.5 and 3 T.

Science.gov (United States)

Attenberger, Ulrike I; Ingrisch, Michael; Dietrich, Olaf; Herrmann, Karin; Nikolaou, Konstantin; Reiser, Maximilian F; Schönberg, Stefan O; Fink, Christian

2009-09-01

Time-resolved pulmonary perfusion MRI requires both high temporal and spatial resolution, which can be achieved by using several nonconventional k-space acquisition techniques. The aim of this study is to compare the image quality of time-resolved 3D pulmonary perfusion MRI with different k-space acquisition techniques in healthy volunteers at 1.5 and 3 T. Ten healthy volunteers underwent contrast-enhanced time-resolved 3D pulmonary MRI on 1.5 and 3 T using the following k-space acquisition techniques: (a) generalized autocalibrating partial parallel acquisition (GRAPPA) with an internal acquisition of reference lines (IRS), (b) GRAPPA with a single "external" acquisition of reference lines (ERS) before the measurement, and (c) a combination of GRAPPA with an internal acquisition of reference lines and view sharing (VS). The spatial resolution was kept constant at both field strengths to exclusively evaluate the influences of the temporal resolution achieved with the different k-space sampling techniques on image quality. The temporal resolutions were 2.11 seconds IRS, 1.31 seconds ERS, and 1.07 VS at 1.5 T and 2.04 seconds IRS, 1.30 seconds ERS, and 1.19 seconds VS at 3 T.Image quality was rated by 2 independent radiologists with regard to signal intensity, perfusion homogeneity, artifacts (eg, wrap around, noise), and visualization of pulmonary vessels using a 3 point scale (1 = nondiagnostic, 2 = moderate, 3 = good). Furthermore, the signal-to-noise ratio in the lungs was assessed. At 1.5 T the lowest image quality (sum score: 154) was observed for the ERS technique and the highest quality for the VS technique (sum score: 201). In contrast, at 3 T images acquired with VS were hampered by strong artifacts and image quality was rated significantly inferior (sum score: 137) compared with IRS (sum score: 180) and ERS (sum score: 174). Comparing 1.5 and 3 T, in particular the overall rating of the IRS technique (sum score: 180) was very similar at both field

2D Tsallis Entropy for Image Segmentation Based on Modified Chaotic Bat Algorithm

Directory of Open Access Journals (Sweden)

Zhiwei Ye

2018-03-01

Full Text Available Image segmentation is a significant step in image analysis and computer vision. Many entropy based approaches have been presented in this topic; among them, Tsallis entropy is one of the best performing methods. However, 1D Tsallis entropy does not consider make use of the spatial correlation information within the neighborhood results might be ruined by noise. Therefore, 2D Tsallis entropy is proposed to solve the problem, and results are compared with 1D Fisher, 1D maximum entropy, 1D cross entropy, 1D Tsallis entropy, fuzzy entropy, 2D Fisher, 2D maximum entropy and 2D cross entropy. On the other hand, due to the existence of huge computational costs, meta-heuristics algorithms like genetic algorithm (GA, particle swarm optimization (PSO, ant colony optimization algorithm (ACO and differential evolution algorithm (DE are used to accelerate the 2D Tsallis entropy thresholding method. In this paper, considering 2D Tsallis entropy as a constrained optimization problem, the optimal thresholds are acquired by maximizing the objective function using a modified chaotic Bat algorithm (MCBA. The proposed algorithm has been tested on some actual and infrared images. The results are compared with that of PSO, GA, ACO and DE and demonstrate that the proposed method outperforms other approaches involved in the paper, which is a feasible and effective option for image segmentation.

How does c-view image quality compare with conventional 2D FFDM?

Science.gov (United States)

Nelson, Jeffrey S; Wells, Jered R; Baker, Jay A; Samei, Ehsan

2016-05-01

The FDA approved the use of digital breast tomosynthesis (DBT) in 2011 as an adjunct to 2D full field digital mammography (FFDM) with the constraint that all DBT acquisitions must be paired with a 2D image to assure adequate interpretative information is provided. Recently manufacturers have developed methods to provide a synthesized 2D image generated from the DBT data with the hope of sparing patients the radiation exposure from the FFDM acquisition. While this much needed alternative effectively reduces the total radiation burden, differences in image quality must also be considered. The goal of this study was to compare the intrinsic image quality of synthesized 2D c-view and 2D FFDM images in terms of resolution, contrast, and noise. Two phantoms were utilized in this study: the American College of Radiology mammography accreditation phantom (ACR phantom) and a novel 3D printed anthropomorphic breast phantom. Both phantoms were imaged using a Hologic Selenia Dimensions 3D system. Analysis of the ACR phantom includes both visual inspection and objective automated analysis using in-house software. Analysis of the 3D anthropomorphic phantom includes visual assessment of resolution and Fourier analysis of the noise. Using ACR-defined scoring criteria for the ACR phantom, the FFDM images scored statistically higher than c-view according to both the average observer and automated scores. In addition, between 50% and 70% of c-view images failed to meet the nominal minimum ACR accreditation requirements-primarily due to fiber breaks. Software analysis demonstrated that c-view provided enhanced visualization of medium and large microcalcification objects; however, the benefits diminished for smaller high contrast objects and all low contrast objects. Visual analysis of the anthropomorphic phantom showed a measureable loss of resolution in the c-view image (11 lp/mm FFDM, 5 lp/mm c-view) and loss in detection of small microcalcification objects. Spectral analysis of the

How does C-VIEW image quality compare with conventional 2D FFDM?

International Nuclear Information System (INIS)

Nelson, Jeffrey S.; Wells, Jered R.; Baker, Jay A.; Samei, Ehsan

2016-01-01

Purpose: The FDA approved the use of digital breast tomosynthesis (DBT) in 2011 as an adjunct to 2D full field digital mammography (FFDM) with the constraint that all DBT acquisitions must be paired with a 2D image to assure adequate interpretative information is provided. Recently manufacturers have developed methods to provide a synthesized 2D image generated from the DBT data with the hope of sparing patients the radiation exposure from the FFDM acquisition. While this much needed alternative effectively reduces the total radiation burden, differences in image quality must also be considered. The goal of this study was to compare the intrinsic image quality of synthesized 2D C-VIEW and 2D FFDM images in terms of resolution, contrast, and noise. Methods: Two phantoms were utilized in this study: the American College of Radiology mammography accreditation phantom (ACR phantom) and a novel 3D printed anthropomorphic breast phantom. Both phantoms were imaged using a Hologic Selenia Dimensions 3D system. Analysis of the ACR phantom includes both visual inspection and objective automated analysis using in-house software. Analysis of the 3D anthropomorphic phantom includes visual assessment of resolution and Fourier analysis of the noise. Results: Using ACR-defined scoring criteria for the ACR phantom, the FFDM images scored statistically higher than C-VIEW according to both the average observer and automated scores. In addition, between 50% and 70% of C-VIEW images failed to meet the nominal minimum ACR accreditation requirements—primarily due to fiber breaks. Software analysis demonstrated that C-VIEW provided enhanced visualization of medium and large microcalcification objects; however, the benefits diminished for smaller high contrast objects and all low contrast objects. Visual analysis of the anthropomorphic phantom showed a measureable loss of resolution in the C-VIEW image (11 lp/mm FFDM, 5 lp/mm C-VIEW) and loss in detection of small microcalcification

How does C-VIEW image quality compare with conventional 2D FFDM?

Energy Technology Data Exchange (ETDEWEB)

Nelson, Jeffrey S., E-mail: nelson.jeffrey@duke.edu; Wells, Jered R. [Department of Radiology, Clinical Imaging Physics Group, Duke University Medical Center, Durham, North Carolina 27705 (United States); Baker, Jay A. [Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Samei, Ehsan [Department of Radiology, Clinical Imaging Physics Group, Duke University Medical Center, Durham, North Carolina 27705 (United States); Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Departments of Biomedical Engineering and Electrical and Computer Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina 27705 (United States)

2016-05-15

Purpose: The FDA approved the use of digital breast tomosynthesis (DBT) in 2011 as an adjunct to 2D full field digital mammography (FFDM) with the constraint that all DBT acquisitions must be paired with a 2D image to assure adequate interpretative information is provided. Recently manufacturers have developed methods to provide a synthesized 2D image generated from the DBT data with the hope of sparing patients the radiation exposure from the FFDM acquisition. While this much needed alternative effectively reduces the total radiation burden, differences in image quality must also be considered. The goal of this study was to compare the intrinsic image quality of synthesized 2D C-VIEW and 2D FFDM images in terms of resolution, contrast, and noise. Methods: Two phantoms were utilized in this study: the American College of Radiology mammography accreditation phantom (ACR phantom) and a novel 3D printed anthropomorphic breast phantom. Both phantoms were imaged using a Hologic Selenia Dimensions 3D system. Analysis of the ACR phantom includes both visual inspection and objective automated analysis using in-house software. Analysis of the 3D anthropomorphic phantom includes visual assessment of resolution and Fourier analysis of the noise. Results: Using ACR-defined scoring criteria for the ACR phantom, the FFDM images scored statistically higher than C-VIEW according to both the average observer and automated scores. In addition, between 50% and 70% of C-VIEW images failed to meet the nominal minimum ACR accreditation requirements—primarily due to fiber breaks. Software analysis demonstrated that C-VIEW provided enhanced visualization of medium and large microcalcification objects; however, the benefits diminished for smaller high contrast objects and all low contrast objects. Visual analysis of the anthropomorphic phantom showed a measureable loss of resolution in the C-VIEW image (11 lp/mm FFDM, 5 lp/mm C-VIEW) and loss in detection of small microcalcification

Spatially-resolved in-situ quantification of biofouling using optical coherence tomography (OCT) and 3D image analysis in a spacer filled channel

KAUST Repository

Fortunato, Luca

2016-11-21

The use of optical coherence tomography (OCT) to investigate biomass in membrane systems has increased with time. OCT is able to characterize the biomass in-situ and non-destructively. In this study, a novel approach to process three-dimensional (3D) OCT scans is proposed. The approach allows obtaining spatially-resolved detailed structural biomass information. The 3D biomass reconstruction enables analysis of the biomass only, obtained by subtracting the time zero scan to all images. A 3D time series analysis of biomass development in a spacer filled channel under representative conditions (cross flow velocity) for a spiral wound membrane element was performed. The flow cell was operated for five days with monitoring of ultrafiltration membrane performance: feed channel pressure drop and permeate flux. The biomass development in the flow cell was detected by OCT before a performance decline was observed. Feed channel pressure drop continuously increased with increasing biomass volume, while flux decline was mainly affected in the initial phase of biomass accumulation. The novel OCT imaging approach enabled the assessment of spatial biomass distribution in the flow cell, discriminating the total biomass volume between the membrane, feed spacer and glass window. Biomass accumulation was stronger on the feed spacer during the early stage of biofouling, impacting the feed channel pressure drop stronger than permeate flux.

Automated three-dimensional tracking of the left ventricular myocardium in time-resolved and dose-modulated cardiac CT images using deformable image registration.

Science.gov (United States)

Gupta, Vikas; Lantz, Jonas; Henriksson, Lilian; Engvall, Jan; Karlsson, Matts; Persson, Anders; Ebbers, Tino

Assessment of myocardial deformation from time-resolved cardiac computed tomography (4D CT) would augment the already available functional information from such an examination without incurring any additional costs. A deformable image registration (DIR) based approach is proposed to allow fast and automatic myocardial tracking in clinical 4D CT images. Left ventricular myocardial tissue displacement through a cardiac cycle was tracked using a B-spline transformation based DIR. Gradient of such displacements allowed Lagrangian strain estimation with respect to end-diastole in clinical 4D CT data from ten subjects with suspected coronary artery disease. Dice similarity coefficient (DSC), point-to-curve error (PTC), and tracking error were used to assess the tracking accuracy. Wilcoxon signed rank test provided significance of tracking errors. Topology preservation was verified using Jacobian of the deformation. Reliability of estimated strains and torsion (normalized twist angle) was tested in subjects with normal function by comparing them with normal strain in the literature. Comparison with manual tracking showed high accuracy (DSC: 0.99±0.05; PTC: 0.56mm±0.47 mm) and resulted in determinant(Jacobian)>0 for all subjects, indicating preservation of topology. Average radial (0.13 mm), angular (0.64) and longitudinal (0.10 mm) tracking errors for the entire cohort were not significant (p > 0.9). For patients with normal function, average strain [circumferential, radial, longitudinal] and peak torsion estimates were: [-23.5%, 31.1%, -17.2%] and 7.22°, respectively. These estimates were in conformity with the reported normal ranges in the existing literature. Accurate wall deformation tracking and subsequent strain estimation are feasible with the proposed method using only routine time-resolved 3D cardiac CT. Copyright © 2018 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.

Time-resolved investigations of the fragmentation dynamic of H2 (D2) in and with ultra-short laser pulses

International Nuclear Information System (INIS)

Ergler, T.

2006-01-01

In course of this work pump-probe experiments aimed to study ultrafast nuclear motion in H 2 (D 2 ) fragmentation by intense 6-25 fs laser pulses have been carried out. In order to perform time-resolved measurements, a Mach-Zehnder interferometer providing two identical synchronized laser pulses with the time-delay variable from 0 to 3000 fs with 300 as accuracy and long-term stability has been built. The laser pulses at the intensities of up to 10 15 W/cm 2 were focused onto a H 2 (D 2 ) molecular beam leading to the ionization or dissociation of the molecules, and the momenta of all charged reactions fragments were measured with a reaction microscope. With 6-7 fs pulses it was possible to probe the time evolution of the bound H + 2 (D + 2 ) nuclear wave packet created by the first (pump) laser pulse, fragmenting the molecule with the second (probe) pulse. A fast delocalization, or ''collapse'', and subsequent ''revival'' of the vibrational wave packet have been observed. In addition, the signatures of the ground state vibrational excitation in neutral D 2 molecule have been found, and the dominance of a new, purely quantum mechanical wave packet preparation mechanism (the so-called ''Lochfrass'') has been proved. In the experiments with 25 fs pulses the theoretically predicted enhancement of the ionization probability for the dissociating H + 2 molecular ion at large internuclear distances has been detected for the first time. (orig.)

Position tracking of moving liver lesion based on real-time registration between 2D ultrasound and 3D preoperative images

International Nuclear Information System (INIS)

Weon, Chijun; Hyun Nam, Woo; Lee, Duhgoon; Ra, Jong Beom; Lee, Jae Young

2015-01-01

Purpose: Registration between 2D ultrasound (US) and 3D preoperative magnetic resonance (MR) (or computed tomography, CT) images has been studied recently for US-guided intervention. However, the existing techniques have some limits, either in the registration speed or the performance. The purpose of this work is to develop a real-time and fully automatic registration system between two intermodal images of the liver, and subsequently an indirect lesion positioning/tracking algorithm based on the registration result, for image-guided interventions. Methods: The proposed position tracking system consists of three stages. In the preoperative stage, the authors acquire several 3D preoperative MR (or CT) images at different respiratory phases. Based on the transformations obtained from nonrigid registration of the acquired 3D images, they then generate a 4D preoperative image along the respiratory phase. In the intraoperative preparatory stage, they properly attach a 3D US transducer to the patient’s body and fix its pose using a holding mechanism. They then acquire a couple of respiratory-controlled 3D US images. Via the rigid registration of these US images to the 3D preoperative images in the 4D image, the pose information of the fixed-pose 3D US transducer is determined with respect to the preoperative image coordinates. As feature(s) to use for the rigid registration, they may choose either internal liver vessels or the inferior vena cava. Since the latter is especially useful in patients with a diffuse liver disease, the authors newly propose using it. In the intraoperative real-time stage, they acquire 2D US images in real-time from the fixed-pose transducer. For each US image, they select candidates for its corresponding 2D preoperative slice from the 4D preoperative MR (or CT) image, based on the predetermined pose information of the transducer. The correct corresponding image is then found among those candidates via real-time 2D registration based on a

High-resolution mapping of 1D and 2D dose distributions using X-band electron paramagnetic resonance imaging

International Nuclear Information System (INIS)

Kolbun, N.; Lund, E.; Adolfsson, E.; Gustafsson, H.

2014-01-01

Electron paramagnetic resonance imaging (EPRI) was performed to visualise 2D dose distributions of homogeneously irradiated potassium dithionate tablets and to demonstrate determination of 1D dose profiles along the height of the tablets. Mathematical correction was applied for each relative dose profile in order to take into account the inhomogeneous response of the resonator using X-band EPRI. The dose profiles are presented with the spatial resolution of 0.6 mm from the acquired 2D images; this value is limited by pixel size, and 1D dose profiles from 1D imaging with spatial resolution of 0.3 mm limited by the intrinsic line-width of potassium dithionate. In this paper, dose profiles from 2D reconstructed electron paramagnetic resonance (EPR) images using the Xepr software package by Bruker are focussed. The conclusion is that using potassium dithionate, the resolution 0.3 mm is sufficient for mapping steep dose gradients if the dosemeters are covering only ±2 mm around the centre of the resonator. (authors)

Photo-magnetic imaging: resolving optical contrast at MRI resolution

International Nuclear Information System (INIS)

Lin Yuting; Thayer, David; Luk, Alex L; Gulsen, Gultekin; Gao Hao

2013-01-01

In this paper, we establish the mathematical framework of a novel imaging technique, namely photo-magnetic imaging (PMI). PMI uses a laser to illuminate biological tissues and measure the induced temperature variations using magnetic resonance imaging (MRI). PMI overcomes the limitation of conventional optical imaging and allows imaging of the optical contrast at MRI spatial resolution. The image reconstruction for PMI, using a finite-element-based algorithm with an iterative approach, is presented in this paper. The quantitative accuracy of PMI is investigated for various inclusion sizes, depths and absorption values. Then, a comparison between conventional diffuse optical tomography (DOT) and PMI is carried out to illustrate the superior performance of PMI. An example is presented showing that two 2 mm diameter inclusions embedded 4.5 mm deep and located side by side in a 25 mm diameter circular geometry medium are recovered as a single 6 mm diameter object with DOT. However, these two objects are not only effectively resolved with PMI, but their true concentrations are also recovered successfully. (paper)

Real-time registration of 3D to 2D ultrasound images for image-guided prostate biopsy.

Science.gov (United States)

Gillies, Derek J; Gardi, Lori; De Silva, Tharindu; Zhao, Shuang-Ren; Fenster, Aaron

2017-09-01

During image-guided prostate biopsy, needles are targeted at tissues that are suspicious of cancer to obtain specimen for histological examination. Unfortunately, patient motion causes targeting errors when using an MR-transrectal ultrasound (TRUS) fusion approach to augment the conventional biopsy procedure. This study aims to develop an automatic motion correction algorithm approaching the frame rate of an ultrasound system to be used in fusion-based prostate biopsy systems. Two modes of operation have been investigated for the clinical implementation of the algorithm: motion compensation using a single user initiated correction performed prior to biopsy, and real-time continuous motion compensation performed automatically as a background process. Retrospective 2D and 3D TRUS patient images acquired prior to biopsy gun firing were registered using an intensity-based algorithm utilizing normalized cross-correlation and Powell's method for optimization. 2D and 3D images were downsampled and cropped to estimate the optimal amount of image information that would perform registrations quickly and accurately. The optimal search order during optimization was also analyzed to avoid local optima in the search space. Error in the algorithm was computed using target registration errors (TREs) from manually identified homologous fiducials in a clinical patient dataset. The algorithm was evaluated for real-time performance using the two different modes of clinical implementations by way of user initiated and continuous motion compensation methods on a tissue mimicking prostate phantom. After implementation in a TRUS-guided system with an image downsampling factor of 4, the proposed approach resulted in a mean ± std TRE and computation time of 1.6 ± 0.6 mm and 57 ± 20 ms respectively. The user initiated mode performed registrations with in-plane, out-of-plane, and roll motions computation times of 108 ± 38 ms, 60 ± 23 ms, and 89 ± 27 ms, respectively, and corresponding

Topology-Preserving Rigid Transformation of 2D Digital Images.

Science.gov (United States)

Ngo, Phuc; Passat, Nicolas; Kenmochi, Yukiko; Talbot, Hugues

2014-02-01

We provide conditions under which 2D digital images preserve their topological properties under rigid transformations. We consider the two most common digital topology models, namely dual adjacency and well-composedness. This paper leads to the proposal of optimal preprocessing strategies that ensure the topological invariance of images under arbitrary rigid transformations. These results and methods are proved to be valid for various kinds of images (binary, gray-level, label), thus providing generic and efficient tools, which can be used in particular in the context of image registration and warping.

Comparison of 3D cube FLAIR with 2D FLAIR for multiple sclerosis imaging at 3 tesla

Energy Technology Data Exchange (ETDEWEB)

Patzig, M.; Brueckmann, H.; Fesl, G. [Muenchen Univ. (Germany). Dept. of Neuroradiology; Burke, M. [GE Healthcare, Solingen (Germany)

2014-05-15

Purpose: Three-dimensional (3 D) MRI sequences allow improved spatial resolution with good signal and contrast properties as well as multiplanar reconstruction. We sought to compare Cube, a 3 D FLAIR sequence, to a standard 2 D FLAIR sequence in multiple sclerosis (MS) imaging. Materials and Methods: Examinations were performed in the clinical routine on a 3.0 Tesla scanner. 12 patients with definite MS were included. Lesions with MS-typical properties on the images of Cube FLAIR and 2 D FLAIR sequences were counted and allocated to different brain regions. Signal-to-noise ratios (SNR) and contrast-to-noise ratios (CNR) were calculated. Results: With 384 the overall number of lesions found with Cube FLAIR was significantly higher than with 2 D FLAIR (N = 221). The difference was mostly accounted for by supratentorial lesions (N = 372 vs. N = 216) while the infratentorial lesion counts were low in both sequences. SNRs and CNRs were significantly higher in CUBE FLAIR with the exception of the CNR of lesion to gray matter, which was not significantly different. Conclusion: Cube FLAIR showed a higher sensitivity for MS lesions compared to a 2 D FLAIR sequence. 3 D FLAIR might replace 2 D FLAIR sequences in MS imaging in the future. (orig.)

2-D Imaging of Electron Temperature in Tokamak Plasmas

International Nuclear Information System (INIS)

Munsat, T.; Mazzucato, E.; Park, H.; Domier, C.W.; Johnson, M.; Luhmann, N.C. Jr.; Wang, J.; Xia, Z.; Classen, I.G.J.; Donne, A.J.H.; Pol, M.J. van de

2004-01-01

By taking advantage of recent developments in millimeter wave imaging technology, an Electron Cyclotron Emission Imaging (ECEI) instrument, capable of simultaneously measuring 128 channels of localized electron temperature over a 2-D map in the poloidal plane, has been developed for the TEXTOR tokamak. Data from the new instrument, detailing the MHD activity associated with a sawtooth crash, is presented

Resolving hot spot microstructure using x-ray penumbral imaging (invited)

Science.gov (United States)

Bachmann, B.; Hilsabeck, T.; Field, J.; Masters, N.; Reed, C.; Pardini, T.; Rygg, J. R.; Alexander, N.; Benedetti, L. R.; Döppner, T.; Forsman, A.; Izumi, N.; LePape, S.; Ma, T.; MacPhee, A. G.; Nagel, S.; Patel, P.; Spears, B.; Landen, O. L.

2016-11-01

We have developed and fielded x-ray penumbral imaging on the National Ignition Facility in order to enable sub-10 μm resolution imaging of stagnated plasma cores (hot spots) of spherically shock compressed spheres and shell implosion targets. By utilizing circular tungsten and tantalum apertures with diameters ranging from 20 μm to 2 mm, in combination with image plate and gated x-ray detectors as well as imaging magnifications ranging from 4 to 64, we have demonstrated high-resolution imaging of hot spot plasmas at x-ray energies above 5 keV. Here we give an overview of the experimental design criteria involved and demonstrate the most relevant influences on the reconstruction of x-ray penumbral images, as well as mitigation strategies of image degrading effects like over-exposed pixels, artifacts, and photon limited source emission. We describe experimental results showing the advantages of x-ray penumbral imaging over conventional Fraunhofer and photon limited pinhole imaging and showcase how internal hot spot microstructures can be resolved.

Resolving hot spot microstructure using x-ray penumbral imaging (invited)

Energy Technology Data Exchange (ETDEWEB)

Bachmann, B., E-mail: bachmann2@llnl.gov; Field, J.; Masters, N.; Pardini, T.; Rygg, J. R.; Benedetti, L. R.; Döppner, T.; Izumi, N.; LePape, S.; Ma, T.; MacPhee, A. G.; Nagel, S.; Patel, P.; Spears, B.; Landen, O. L. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Hilsabeck, T.; Reed, C.; Alexander, N.; Forsman, A. [General Atomics, San Diego, California 92186 (United States)

2016-11-15

We have developed and fielded x-ray penumbral imaging on the National Ignition Facility in order to enable sub-10 μm resolution imaging of stagnated plasma cores (hot spots) of spherically shock compressed spheres and shell implosion targets. By utilizing circular tungsten and tantalum apertures with diameters ranging from 20 μm to 2 mm, in combination with image plate and gated x-ray detectors as well as imaging magnifications ranging from 4 to 64, we have demonstrated high-resolution imaging of hot spot plasmas at x-ray energies above 5 keV. Here we give an overview of the experimental design criteria involved and demonstrate the most relevant influences on the reconstruction of x-ray penumbral images, as well as mitigation strategies of image degrading effects like over-exposed pixels, artifacts, and photon limited source emission. We describe experimental results showing the advantages of x-ray penumbral imaging over conventional Fraunhofer and photon limited pinhole imaging and showcase how internal hot spot microstructures can be resolved.

Resolving hot spot microstructure using x-ray penumbral imaging (invited).

Science.gov (United States)

Bachmann, B; Hilsabeck, T; Field, J; Masters, N; Reed, C; Pardini, T; Rygg, J R; Alexander, N; Benedetti, L R; Döppner, T; Forsman, A; Izumi, N; LePape, S; Ma, T; MacPhee, A G; Nagel, S; Patel, P; Spears, B; Landen, O L

2016-11-01

We have developed and fielded x-ray penumbral imaging on the National Ignition Facility in order to enable sub-10 μm resolution imaging of stagnated plasma cores (hot spots) of spherically shock compressed spheres and shell implosion targets. By utilizing circular tungsten and tantalum apertures with diameters ranging from 20 μm to 2 mm, in combination with image plate and gated x-ray detectors as well as imaging magnifications ranging from 4 to 64, we have demonstrated high-resolution imaging of hot spot plasmas at x-ray energies above 5 keV. Here we give an overview of the experimental design criteria involved and demonstrate the most relevant influences on the reconstruction of x-ray penumbral images, as well as mitigation strategies of image degrading effects like over-exposed pixels, artifacts, and photon limited source emission. We describe experimental results showing the advantages of x-ray penumbral imaging over conventional Fraunhofer and photon limited pinhole imaging and showcase how internal hot spot microstructures can be resolved.

Resolving hot spot microstructure using x-ray penumbral imaging (invited)

International Nuclear Information System (INIS)

Bachmann, B.; Field, J.; Masters, N.; Pardini, T.; Rygg, J. R.; Benedetti, L. R.; Döppner, T.; Izumi, N.; LePape, S.; Ma, T.; MacPhee, A. G.; Nagel, S.; Patel, P.; Spears, B.; Landen, O. L.; Hilsabeck, T.; Reed, C.; Alexander, N.; Forsman, A.

2016-01-01

We have developed and fielded x-ray penumbral imaging on the National Ignition Facility in order to enable sub-10 μm resolution imaging of stagnated plasma cores (hot spots) of spherically shock compressed spheres and shell implosion targets. By utilizing circular tungsten and tantalum apertures with diameters ranging from 20 μm to 2 mm, in combination with image plate and gated x-ray detectors as well as imaging magnifications ranging from 4 to 64, we have demonstrated high-resolution imaging of hot spot plasmas at x-ray energies above 5 keV. Here we give an overview of the experimental design criteria involved and demonstrate the most relevant influences on the reconstruction of x-ray penumbral images, as well as mitigation strategies of image degrading effects like over-exposed pixels, artifacts, and photon limited source emission. We describe experimental results showing the advantages of x-ray penumbral imaging over conventional Fraunhofer and photon limited pinhole imaging and showcase how internal hot spot microstructures can be resolved.

Prior-knowledge Fitting of Accelerated Five-dimensional Echo Planar J-resolved Spectroscopic Imaging: Effect of Nonlinear Reconstruction on Quantitation.

Science.gov (United States)

Iqbal, Zohaib; Wilson, Neil E; Thomas, M Albert

2017-07-24

1 H Magnetic Resonance Spectroscopic imaging (SI) is a powerful tool capable of investigating metabolism in vivo from mul- tiple regions. However, SI techniques are time consuming, and are therefore difficult to implement clinically. By applying non-uniform sampling (NUS) and compressed sensing (CS) reconstruction, it is possible to accelerate these scans while re- taining key spectral information. One recently developed method that utilizes this type of acceleration is the five-dimensional echo planar J-resolved spectroscopic imaging (5D EP-JRESI) sequence, which is capable of obtaining two-dimensional (2D) spectra from three spatial dimensions. The prior-knowledge fitting (ProFit) algorithm is typically used to quantify 2D spectra in vivo, however the effects of NUS and CS reconstruction on the quantitation results are unknown. This study utilized a simulated brain phantom to investigate the errors introduced through the acceleration methods. Errors (normalized root mean square error >15%) were found between metabolite concentrations after twelve-fold acceleration for several low concentra- tion (OGM) human brain matter were quantified in vivo using the 5D EP-JRESI sequence with eight-fold acceleration.

Advanced 3-D Ultrasound Imaging

DEFF Research Database (Denmark)

Rasmussen, Morten Fischer

The main purpose of the PhD project was to develop methods that increase the 3-D ultrasound imaging quality available for the medical personnel in the clinic. Acquiring a 3-D volume gives the medical doctor the freedom to investigate the measured anatomy in any slice desirable after the scan has...... been completed. This allows for precise measurements of organs dimensions and makes the scan more operator independent. Real-time 3-D ultrasound imaging is still not as widespread in use in the clinics as 2-D imaging. A limiting factor has traditionally been the low image quality achievable using...... a channel limited 2-D transducer array and the conventional 3-D beamforming technique, Parallel Beamforming. The first part of the scientific contributions demonstrate that 3-D synthetic aperture imaging achieves a better image quality than the Parallel Beamforming technique. Data were obtained using both...

Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies.

Science.gov (United States)

Mach, Robert H; Luedtke, Robert R

2018-03-01

The dopamine D2-like receptors (ie, D2/3 receptors) have been the most extensively studied CNS receptor with Positron Emission Tomography (PET). The 3 different radiotracers that have been used in these studies are [ 11 C]raclopride, [ 18 F]fallypride, and [ 11 C]PHNO. Because these radiotracers have a high affinity for both dopamine D2 and D3 receptors, the density of dopamine receptors in the CNS is reported as the D2/3 binding potential, which reflects a measure of the density of both receptor subtypes. Although the development of D2- and D3-selective PET radiotracers has been an active area of research for many years, this by and large presents an unmet need in the area of translational PET imaging studies. This article discusses some of the challenges that have inhibited progress in this area of research and the current status of the development of subtype selective radiotracers for imaging D3 and D2 dopamine receptors with PET. Copyright © 2017 John Wiley & Sons, Ltd.

2D and 3D imaging resolution trade-offs in quantifying pore throats for prediction of permeability

Energy Technology Data Exchange (ETDEWEB)

Beckingham, Lauren E.; Peters, Catherine A.; Um, Wooyong; Jones, Keith W.; Lindquist, W.Brent

2013-09-03

Although the impact of subsurface geochemical reactions on porosity is relatively well understood, changes in permeability remain difficult to estimate. In this work, pore-network modeling was used to predict permeability based on pore- and pore-throat size distributions determined from analysis of 2D scanning electron microscopy (SEM) images of thin sections and 3D X-ray computed microtomography (CMT) data. The analyzed specimens were a Viking sandstone sample from the Alberta sedimentary basin and an experimental column of reacted Hanford sediments. For the column, a decrease in permeability due to mineral precipitation was estimated, but the permeability estimates were dependent on imaging technique and resolution. X-ray CT imaging has the advantage of reconstructing a 3D pore network while 2D SEM imaging can easily analyze sub-grain and intragranular variations in mineralogy. Pore network models informed by analyses of 2D and 3D images at comparable resolutions produced permeability esti- mates with relatively good agreement. Large discrepancies in predicted permeabilities resulted from small variations in image resolution. Images with resolutions 0.4 to 4 lm predicted permeabilities differ- ing by orders of magnitude. While lower-resolution scans can analyze larger specimens, small pore throats may be missed due to resolution limitations, which in turn overestimates permeability in a pore-network model in which pore-to-pore conductances are statistically assigned. Conversely, high-res- olution scans are capable of capturing small pore throats, but if they are not actually flow-conducting predicted permeabilities will be below expected values. In addition, permeability is underestimated due to misinterpreting surface-roughness features as small pore throats. Comparison of permeability pre- dictions with expected and measured permeability values showed that the largest discrepancies resulted from the highest resolution images and the best predictions of

Real-time 2-D Phased Array Vector Flow Imaging

DEFF Research Database (Denmark)

Holbek, Simon; Hansen, Kristoffer Lindskov; Fogh, Nikolaj

2018-01-01

Echocardiography examination of the blood flow is currently either restricted to 1-D techniques in real-time or experimental off-line 2-D methods. This paper presents an implementation of transverse oscillation for real-time 2-D vector flow imaging (VFI) on a commercial BK Ultrasound scanner....... A large field-of-view (FOV) sequence for studying flow dynamics at 11 frames per second (fps) and a sequence for studying peak systolic velocities (PSV) with a narrow FOV at 36 fps were validated. The VFI sequences were validated in a flow-rig with continuous laminar parabolic flow and in a pulsating flow...

3D Fast Spin Echo T2-weighted Contrast for Imaging the Female Cervix

Science.gov (United States)

Vargas Sanchez, Andrea Fernanda

Magnetic Resonance Imaging (MRI) with T2-weighted contrast is the preferred modality for treatment planning and monitoring of cervical cancer. Current clinical protocols image the volume of interest multiple times with two dimensional (2D) T2-weighted MRI techniques. It is of interest to replace these multiple 2D acquisitions with a single three dimensional (3D) MRI acquisition to save time. However, at present the image contrast of standard 3D MRI does not distinguish cervical healthy tissue from cancerous tissue. The purpose of this thesis is to better understand the underlying factors that govern the contrast of 3D MRI and exploit this understanding via sequence modifications to improve the contrast. Numerical simulations are developed to predict observed contrast alterations and to propose an improvement. Improvements of image contrast are shown in simulation and with healthy volunteers. Reported results are only preliminary but a promising start to establish definitively 3D MRI for cervical cancer applications.

GPU accelerated generation of digitally reconstructed radiographs for 2-D/3-D image registration.

Science.gov (United States)

Dorgham, Osama M; Laycock, Stephen D; Fisher, Mark H

2012-09-01

Recent advances in programming languages for graphics processing units (GPUs) provide developers with a convenient way of implementing applications which can be executed on the CPU and GPU interchangeably. GPUs are becoming relatively cheap, powerful, and widely available hardware components, which can be used to perform intensive calculations. The last decade of hardware performance developments shows that GPU-based computation is progressing significantly faster than CPU-based computation, particularly if one considers the execution of highly parallelisable algorithms. Future predictions illustrate that this trend is likely to continue. In this paper, we introduce a way of accelerating 2-D/3-D image registration by developing a hybrid system which executes on the CPU and utilizes the GPU for parallelizing the generation of digitally reconstructed radiographs (DRRs). Based on the advancements of the GPU over the CPU, it is timely to exploit the benefits of many-core GPU technology by developing algorithms for DRR generation. Although some previous work has investigated the rendering of DRRs using the GPU, this paper investigates approximations which reduce the computational overhead while still maintaining a quality consistent with that needed for 2-D/3-D registration with sufficient accuracy to be clinically acceptable in certain applications of radiation oncology. Furthermore, by comparing implementations of 2-D/3-D registration on the CPU and GPU, we investigate current performance and propose an optimal framework for PC implementations addressing the rigid registration problem. Using this framework, we are able to render DRR images from a 256×256×133 CT volume in ~24 ms using an NVidia GeForce 8800 GTX and in ~2 ms using NVidia GeForce GTX 580. In addition to applications requiring fast automatic patient setup, these levels of performance suggest image-guided radiation therapy at video frame rates is technically feasible using relatively low cost PC

Surface topography characterization using 3D stereoscopic reconstruction of SEM images

Science.gov (United States)

Vedantha Krishna, Amogh; Flys, Olena; Reddy, Vijeth V.; Rosén, B. G.

2018-06-01

A major drawback of the optical microscope is its limitation to resolve finer details. Many microscopes have been developed to overcome the limitations set by the diffraction of visible light. The scanning electron microscope (SEM) is one such alternative: it uses electrons for imaging, which have much smaller wavelength than photons. As a result high magnification with superior image resolution can be achieved. However, SEM generates 2D images which provide limited data for surface measurements and analysis. Often many research areas require the knowledge of 3D structures as they contribute to a comprehensive understanding of microstructure by allowing effective measurements and qualitative visualization of the samples under study. For this reason, stereo photogrammetry technique is employed to convert SEM images into 3D measurable data. This paper aims to utilize a stereoscopic reconstruction technique as a reliable method for characterization of surface topography. Reconstructed results from SEM images are compared with coherence scanning interferometer (CSI) results obtained by measuring a roughness reference standard sample. This paper presents a method to select the most robust/consistent surface texture parameters that are insensitive to the uncertainties involved in the reconstruction technique itself. Results from the two-stereoscopic reconstruction algorithms are also documented in this paper.

A hybrid breath hold and continued respiration-triggered technique for time-resolved 3D MRI perfusion studies in lung cancer

International Nuclear Information System (INIS)

Hintze, C.; Stemmer, A.; Bock, M.

2010-01-01

Assessment of lung cancer perfusion is impaired by respiratory motion. Imaging times for contrast agent wash-out studies often exceed breath hold capabilities, and respiration triggering reduces temporal resolution. Temporally resolved volume acquisition of entire tumors is required to assess heterogeneity. Therefore, we developed and evaluated an MR measurement technique that exceeds a single breath hold, and provides a variable temporal resolution during acquisition while suspending breath-dependent motion. 20 patients with suspected lung cancer were subjected to perfusion studies using a spoiled 3D gradient echo sequence after bolus injection of 0.07 mmol/kg body weight of Gd-DTPA. 10 acquisitions in expiratory breath hold were followed by 50 navigator-triggered acquisitions under free breathing. Post-processing allowed for co-registration of the 3D data sets. An ROI-based visualization of the signal-time curves was performed. In all cases motion-suspended, time-resolved volume data sets (40 x 33 x 10 cm 3 , voxel size: 2.1 x 2.1 x 5.0 mm 3 ) were generated with a variable, initially high temporal resolution (2.25 sec) that was synchronized with the breath pattern and covered up to 8(1)/(2) min. In 7 / 20 cases a remaining offset could be reduced by rigid co-registration. The tumors showed fast wash-in, followed by rapid signal decay (8 / 20) or a plateau. The feasibility of a perfusion study with hybrid breath hold and navigator-triggered time-resolved 3D MRI which combines high initial temporal resolution during breath hold with a long wash-out period under free breathing was demonstrated. (orig.)

2D array design based on Fermat spiral for ultrasound imaging.

Science.gov (United States)

Martínez-Graullera, Oscar; Martín, Carlos J; Godoy, Gregorio; Ullate, Luis G

2010-02-01

The main challenge faced by 3D ultrasonic imaging with 2D array transducers is the large number of elements required to achieve an acceptable level of quality in the images. Therefore, the optimisation of the array layout, in order to reduce the number of active elements in the aperture, has been a research topic in the last years. Nowadays, array technology has made viable the production of 2D arrays with larger flexibility on elements size, shape and position, allowing to study other configurations different to the classical matrix organisation, such as circular, archimedes spiral or polygonal layout between others. In this work, the problem of designing an imaging system array with large apertures and a very limited number of active elements (N(e)=128 and N(e)=256) using the Fermat spiral layout has been studied. As summary, a general discussion about the most interesting cases is presented.

Reproducing 2D breast mammography images with 3D printed phantoms

Science.gov (United States)

Clark, Matthew; Ghammraoui, Bahaa; Badal, Andreu

2016-03-01

Mammography is currently the standard imaging modality used to screen women for breast abnormalities and, as a result, it is a tool of great importance for the early detection of breast cancer. Physical phantoms are commonly used as surrogates of breast tissue to evaluate some aspects of the performance of mammography systems. However, most phantoms do not reproduce the anatomic heterogeneity of real breasts. New fabrication technologies, such as 3D printing, have created the opportunity to build more complex, anatomically realistic breast phantoms that could potentially assist in the evaluation of mammography systems. The primary objective of this work is to present a simple, easily reproducible methodology to design and print 3D objects that replicate the attenuation profile observed in real 2D mammograms. The secondary objective is to evaluate the capabilities and limitations of the competing 3D printing technologies, and characterize the x-ray properties of the different materials they use. Printable phantoms can be created using the open-source code introduced in this work, which processes a raw mammography image to estimate the amount of x-ray attenuation at each pixel, and outputs a triangle mesh object that encodes the observed attenuation map. The conversion from the observed pixel gray value to a column of printed material with equivalent attenuation requires certain assumptions and knowledge of multiple imaging system parameters, such as x-ray energy spectrum, source-to-object distance, compressed breast thickness, and average breast material attenuation. A detailed description of the new software, a characterization of the printed materials using x-ray spectroscopy, and an evaluation of the realism of the sample printed phantoms are presented.

Testing the resolving power of 2-D K{sup +} K{sup +} interferometry at Ags energies

Energy Technology Data Exchange (ETDEWEB)

Roldao, Cristiane G.; Padula, Sandra S. [Instituto de Fisica Teorica (IFT), Sao Paulo, SP (Brazil)

1998-12-31

Adopting a procedure previously proposed to quantitatively study pion interferometry, an equivalent 2-D {sub X}{sup 2} analysis was performed to test the resolving power of that method when applied to less favorable conditions, i.e., when non significant contribution from long lived resonances is expected, as in kaon interferometry. For that purpose, use is made of the preliminary E859 K{sup +} K{sup +} interferometry data from Si+Au collisions at 14.6 A GeV/c. Less sensitivity is achieved in the present case, although it is shown that it is still possible to distinguish two distinct decoupling geometries. The possible compatibility of the data with zero decoupling proper time interval, suggested by the experimental fit, is also investigated and seems to be ruled out when considering dynamical models with expanding sources. (author) 10 refs., 2 figs., 1 tab.

Advantages of time-resolved contrast-enhanced 4D MR angiography in splenic arterial steal syndrome.

Science.gov (United States)

Obmann, Verena C; Chalian, Majid; Mansoori, Bahar; Sanchez, Edmund; Gulani, Vikas

2018-03-07

Splenic artery steal syndrome (SASS) is a severe complication affecting up to 10% of orthotopic liver transplant (OLT) patients. In this case report, we present a 35-year-old male with OLT secondary to liver failure due to hemochromatosis, who developed SASS. We describe potential application of different imaging techniques for diagnosis of SASS with focus on the value of time-resolved contrast enhanced 4D magnetic resonance angiography (MRA). Copyright © 2018 Elsevier Inc. All rights reserved.

Novel Super-Resolution Approach to Time-Resolved Volumetric 4-Dimensional Magnetic Resonance Imaging With High Spatiotemporal Resolution for Multi-Breathing Cycle Motion Assessment

International Nuclear Information System (INIS)

Li, Guang; Wei, Jie; Kadbi, Mo; Moody, Jason; Sun, August; Zhang, Shirong; Markova, Svetlana; Zakian, Kristen; Hunt, Margie; Deasy, Joseph O.

2017-01-01

Purpose: To develop and evaluate a super-resolution approach to reconstruct time-resolved 4-dimensional magnetic resonance imaging (TR-4DMRI) with a high spatiotemporal resolution for multi-breathing cycle motion assessment. Methods and Materials: A super-resolution approach was developed to combine fast 3-dimensional (3D) cine MRI with low resolution during free breathing (FB) and high-resolution 3D static MRI during breath hold (BH) using deformable image registration. A T1-weighted, turbo field echo sequence, coronal 3D cine acquisition, partial Fourier approximation, and SENSitivity Encoding parallel acceleration were used. The same MRI pulse sequence, field of view, and acceleration techniques were applied in both FB and BH acquisitions; the intensity-based Demons deformable image registration method was used. Under an institutional review board–approved protocol, 7 volunteers were studied with 3D cine FB scan (voxel size: 5 × 5 × 5 mm"3) at 2 Hz for 40 seconds and a 3D static BH scan (2 × 2 × 2 mm"3). To examine the image fidelity of 3D cine and super-resolution TR-4DMRI, a mobile gel phantom with multi-internal targets was scanned at 3 speeds and compared with the 3D static image. Image similarity among 3D cine, 4DMRI, and 3D static was evaluated visually using difference image and quantitatively using voxel intensity correlation and Dice index (phantom only). Multi-breathing-cycle waveforms were extracted and compared in both phantom and volunteer images using the 3D cine as the references. Results: Mild imaging artifacts were found in the 3D cine and TR-4DMRI of the mobile gel phantom with a Dice index of >0.95. Among 7 volunteers, the super-resolution TR-4DMRI yielded high voxel-intensity correlation (0.92 ± 0.05) and low voxel-intensity difference (<0.05). The detected motion differences between TR-4DMRI and 3D cine were −0.2 ± 0.5 mm (phantom) and −0.2 ± 1.9 mm (diaphragms). Conclusion: Super-resolution TR-4DMRI has been

Novel Super-Resolution Approach to Time-Resolved Volumetric 4-Dimensional Magnetic Resonance Imaging With High Spatiotemporal Resolution for Multi-Breathing Cycle Motion Assessment

Energy Technology Data Exchange (ETDEWEB)

Li, Guang, E-mail: lig2@mskcc.org [Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Wei, Jie [Department of Computer Science, City College of New York, New York, New York (United States); Kadbi, Mo [Philips Healthcare, MR Therapy Cleveland, Ohio (United States); Moody, Jason; Sun, August; Zhang, Shirong; Markova, Svetlana; Zakian, Kristen; Hunt, Margie; Deasy, Joseph O. [Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York (United States)

2017-06-01

Purpose: To develop and evaluate a super-resolution approach to reconstruct time-resolved 4-dimensional magnetic resonance imaging (TR-4DMRI) with a high spatiotemporal resolution for multi-breathing cycle motion assessment. Methods and Materials: A super-resolution approach was developed to combine fast 3-dimensional (3D) cine MRI with low resolution during free breathing (FB) and high-resolution 3D static MRI during breath hold (BH) using deformable image registration. A T1-weighted, turbo field echo sequence, coronal 3D cine acquisition, partial Fourier approximation, and SENSitivity Encoding parallel acceleration were used. The same MRI pulse sequence, field of view, and acceleration techniques were applied in both FB and BH acquisitions; the intensity-based Demons deformable image registration method was used. Under an institutional review board–approved protocol, 7 volunteers were studied with 3D cine FB scan (voxel size: 5 × 5 × 5 mm{sup 3}) at 2 Hz for 40 seconds and a 3D static BH scan (2 × 2 × 2 mm{sup 3}). To examine the image fidelity of 3D cine and super-resolution TR-4DMRI, a mobile gel phantom with multi-internal targets was scanned at 3 speeds and compared with the 3D static image. Image similarity among 3D cine, 4DMRI, and 3D static was evaluated visually using difference image and quantitatively using voxel intensity correlation and Dice index (phantom only). Multi-breathing-cycle waveforms were extracted and compared in both phantom and volunteer images using the 3D cine as the references. Results: Mild imaging artifacts were found in the 3D cine and TR-4DMRI of the mobile gel phantom with a Dice index of >0.95. Among 7 volunteers, the super-resolution TR-4DMRI yielded high voxel-intensity correlation (0.92 ± 0.05) and low voxel-intensity difference (<0.05). The detected motion differences between TR-4DMRI and 3D cine were −0.2 ± 0.5 mm (phantom) and −0.2 ± 1.9 mm (diaphragms). Conclusion: Super-resolution TR-4

Automatic Depth Extraction from 2D Images Using a Cluster-Based Learning Framework.

Science.gov (United States)

Herrera, Jose L; Del-Blanco, Carlos R; Garcia, Narciso

2018-07-01

There has been a significant increase in the availability of 3D players and displays in the last years. Nonetheless, the amount of 3D content has not experimented an increment of such magnitude. To alleviate this problem, many algorithms for converting images and videos from 2D to 3D have been proposed. Here, we present an automatic learning-based 2D-3D image conversion approach, based on the key hypothesis that color images with similar structure likely present a similar depth structure. The presented algorithm estimates the depth of a color query image using the prior knowledge provided by a repository of color + depth images. The algorithm clusters this database attending to their structural similarity, and then creates a representative of each color-depth image cluster that will be used as prior depth map. The selection of the appropriate prior depth map corresponding to one given color query image is accomplished by comparing the structural similarity in the color domain between the query image and the database. The comparison is based on a K-Nearest Neighbor framework that uses a learning procedure to build an adaptive combination of image feature descriptors. The best correspondences determine the cluster, and in turn the associated prior depth map. Finally, this prior estimation is enhanced through a segmentation-guided filtering that obtains the final depth map estimation. This approach has been tested using two publicly available databases, and compared with several state-of-the-art algorithms in order to prove its efficiency.

2D-3D radiograph to cone-beam computed tomography (CBCT) registration for C-arm image-guided robotic surgery.

Science.gov (United States)

Liu, Wen Pei; Otake, Yoshito; Azizian, Mahdi; Wagner, Oliver J; Sorger, Jonathan M; Armand, Mehran; Taylor, Russell H

2015-08-01

C-arm radiographs are commonly used for intraoperative image guidance in surgical interventions. Fluoroscopy is a cost-effective real-time modality, although image quality can vary greatly depending on the target anatomy. Cone-beam computed tomography (CBCT) scans are sometimes available, so 2D-3D registration is needed for intra-procedural guidance. C-arm radiographs were registered to CBCT scans and used for 3D localization of peritumor fiducials during a minimally invasive thoracic intervention with a da Vinci Si robot. Intensity-based 2D-3D registration of intraoperative radiographs to CBCT was performed. The feasible range of X-ray projections achievable by a C-arm positioned around a da Vinci Si surgical robot, configured for robotic wedge resection, was determined using phantom models. Experiments were conducted on synthetic phantoms and animals imaged with an OEC 9600 and a Siemens Artis zeego, representing the spectrum of different C-arm systems currently available for clinical use. The image guidance workflow was feasible using either an optically tracked OEC 9600 or a Siemens Artis zeego C-arm, resulting in an angular difference of Δθ:∼ 30°. The two C-arm systems provided TRE mean ≤ 2.5 mm and TRE mean ≤ 2.0 mm, respectively (i.e., comparable to standard clinical intraoperative navigation systems). C-arm 3D localization from dual 2D-3D registered radiographs was feasible and applicable for intraoperative image guidance during da Vinci robotic thoracic interventions using the proposed workflow. Tissue deformation and in vivo experiments are required before clinical evaluation of this system.

A software tool for automatic classification and segmentation of 2D/3D medical images

International Nuclear Information System (INIS)

Strzelecki, Michal; Szczypinski, Piotr; Materka, Andrzej; Klepaczko, Artur

2013-01-01

Modern medical diagnosis utilizes techniques of visualization of human internal organs (CT, MRI) or of its metabolism (PET). However, evaluation of acquired images made by human experts is usually subjective and qualitative only. Quantitative analysis of MR data, including tissue classification and segmentation, is necessary to perform e.g. attenuation compensation, motion detection, and correction of partial volume effect in PET images, acquired with PET/MR scanners. This article presents briefly a MaZda software package, which supports 2D and 3D medical image analysis aiming at quantification of image texture. MaZda implements procedures for evaluation, selection and extraction of highly discriminative texture attributes combined with various classification, visualization and segmentation tools. Examples of MaZda application in medical studies are also provided

A software tool for automatic classification and segmentation of 2D/3D medical images

Energy Technology Data Exchange (ETDEWEB)

Strzelecki, Michal, E-mail: michal.strzelecki@p.lodz.pl [Institute of Electronics, Technical University of Lodz, Wolczanska 211/215, 90-924 Lodz (Poland); Szczypinski, Piotr; Materka, Andrzej; Klepaczko, Artur [Institute of Electronics, Technical University of Lodz, Wolczanska 211/215, 90-924 Lodz (Poland)

2013-02-21

Modern medical diagnosis utilizes techniques of visualization of human internal organs (CT, MRI) or of its metabolism (PET). However, evaluation of acquired images made by human experts is usually subjective and qualitative only. Quantitative analysis of MR data, including tissue classification and segmentation, is necessary to perform e.g. attenuation compensation, motion detection, and correction of partial volume effect in PET images, acquired with PET/MR scanners. This article presents briefly a MaZda software package, which supports 2D and 3D medical image analysis aiming at quantification of image texture. MaZda implements procedures for evaluation, selection and extraction of highly discriminative texture attributes combined with various classification, visualization and segmentation tools. Examples of MaZda application in medical studies are also provided.

3D visualisation of the middle ear and adjacent structures using reconstructed multi-slice CT datasets, correlating 3D images and virtual endoscopy to the 2D cross-sectional images

International Nuclear Information System (INIS)

Rodt, T.; Ratiu, P.; Kacher, D.F.; Anderson, M.; Jolesz, F.A.; Kikinis, R.; Becker, H.; Bartling, S.

2002-01-01

The 3D imaging of the middle ear facilitates better understanding of the patient's anatomy. Cross-sectional slices, however, often allow a more accurate evaluation of anatomical structures, as some detail may be lost through post-processing. In order to demonstrate the advantages of combining both approaches, we performed computed tomography (CT) imaging in two normal and 15 different pathological cases, and the 3D models were correlated to the cross-sectional CT slices. Reconstructed CT datasets were acquired by multi-slice CT. Post-processing was performed using the in-house software ''3D Slicer'', applying thresholding and manual segmentation. 3D models of the individual anatomical structures were generated and displayed in different colours. The display of relevant anatomical and pathological structures was evaluated in the greyscale 2D slices, 3D images, and the 2D slices showing the segmented 2D anatomy in different colours for each structure. Correlating 2D slices to the 3D models and virtual endoscopy helps to combine the advantages of each method. As generating 3D models can be extremely time-consuming, this approach can be a clinically applicable way of gaining a 3D understanding of the patient's anatomy by using models as a reference. Furthermore, it can help radiologists and otolaryngologists evaluating the 2D slices by adding the correct 3D information that would otherwise have to be mentally integrated. The method can be applied to radiological diagnosis, surgical planning, and especially, to teaching. (orig.)

Symmetries of the 2D magnetic particle imaging system matrix

International Nuclear Information System (INIS)

Weber, A; Knopp, T

2015-01-01

In magnetic particle imaging (MPI), the relation between the particle distribution and the measurement signal can be described by a linear system of equations. For 1D imaging, it can be shown that the system matrix can be expressed as a product of a convolution matrix and a Chebyshev transformation matrix. For multidimensional imaging, the structure of the MPI system matrix is not yet fully explored as the sampling trajectory complicates the physical model. It has been experimentally found that the MPI system matrix rows have symmetries and look similar to the tensor products of Chebyshev polynomials. In this work we will mathematically prove that the 2D MPI system matrix has symmetries that can be used for matrix compression. (paper)

Denoising time-resolved microscopy image sequences with singular value thresholding

Energy Technology Data Exchange (ETDEWEB)

Furnival, Tom, E-mail: tjof2@cam.ac.uk; Leary, Rowan K., E-mail: rkl26@cam.ac.uk; Midgley, Paul A., E-mail: pam33@cam.ac.uk

2017-07-15

Time-resolved imaging in microscopy is important for the direct observation of a range of dynamic processes in both the physical and life sciences. However, the image sequences are often corrupted by noise, either as a result of high frame rates or a need to limit the radiation dose received by the sample. Here we exploit both spatial and temporal correlations using low-rank matrix recovery methods to denoise microscopy image sequences. We also make use of an unbiased risk estimator to address the issue of how much thresholding to apply in a robust and automated manner. The performance of the technique is demonstrated using simulated image sequences, as well as experimental scanning transmission electron microscopy data, where surface adatom motion and nanoparticle structural dynamics are recovered at rates of up to 32 frames per second. - Highlights: • Correlations in space and time are harnessed to denoise microscopy image sequences. • A robust estimator provides automated selection of the denoising parameter. • Motion tracking and automated noise estimation provides a versatile algorithm. • Application to time-resolved STEM enables study of atomic and nanoparticle dynamics.

Feasibility study on 3D image reconstruction from 2D orthogonal cine-MRI for MRI-guided radiotherapy.

Science.gov (United States)

Paganelli, Chiara; Lee, Danny; Kipritidis, John; Whelan, Brendan; Greer, Peter B; Baroni, Guido; Riboldi, Marco; Keall, Paul

2018-02-11

In-room MRI is a promising image guidance strategy in external beam radiotherapy to acquire volumetric information for moving targets. However, limitations in spatio-temporal resolution led several authors to use 2D orthogonal images for guidance. The aim of this work is to present a method to concurrently compensate for non-rigid tumour motion and provide an approach for 3D reconstruction from 2D orthogonal cine-MRI slices for MRI-guided treatments. Free-breathing sagittal/coronal interleaved 2D cine-MRI were acquired in addition to a pre-treatment 3D volume in two patients. We performed deformable image registration (DIR) between cine-MRI slices and corresponding slices in the pre-treatment 3D volume. Based on an extrapolation of the interleaved 2D motion fields, the 3D motion field was estimated and used to warp the pre-treatment volume. Due to the lack of a ground truth for patients, the method was validated on a digital 4D lung phantom. On the phantom, the 3D reconstruction method was able to compensate for tumour motion and compared favourably to the results of previously adopted strategies. The difference in the 3D motion fields between the phantom and the extrapolated motion was 0.4 ± 0.3 mm for tumour and 0.8 ± 1.5 mm for whole anatomy, demonstrating feasibility of performing a 3D volumetric reconstruction directly from 2D orthogonal cine-MRI slices. Application of the method to patient data confirmed the feasibility of utilizing this method in real world scenarios. Preliminary results on phantom and patient cases confirm the feasibility of the proposed approach in an MRI-guided scenario, especially for non-rigid tumour motion compensation. © 2018 The Royal Australian and New Zealand College of Radiologists.

From 2D PET to 3D PET. Issues of data representation and image reconstruction

International Nuclear Information System (INIS)

Gundlich, B.; Musmann, P.; Weber, S.; Nix, O.; Semmler, W.

2006-01-01

Positron emission tomography (PET), intrinsically a 3D imaging technique, was for a long time exclusively operated in 2D mode, using septa to shield the detectors from photons emitted obliquely to the detector planes. However, the use of septa results in a considerable loss of sensitivity. From the late 1980s, significant efforts have been made to develop a methodology for the acquisition and reconstruction of 3D PET data. This paper focuses on the differences between data acquisition in 2D and 3D mode, especially in terms of data set sizes and representation. Although the real time data acquisition aspect in 3D has been mostly solved in modern PET scanner systems, there still remain questions on how to represent and how to make best use of the information contained in the acquired data sets. Data representation methods, such as list-mode and matrix-based methods, possibly with additional compression, will be discussed. Moving from 2D to 3D PET has major implications on the way these data are reconstructed to images. Two fundamentally different approaches exist, the analytical one and the iterative one. Both, at different expenses, can be extended to directly handle 3D data sets. Either way the computational burden increases heavily compared to 2D reconstruction. One possibility to benefit from the increased sensitivity in 3D PET while sticking to high-performance 2D reconstruction algorithms is to rebin 3D into 2D data sets. The value of data rebinning will be explored. An ever increasing computing power and the concept of distributed or parallel computing have made direct 3D reconstruction feasible. Following a short review of reconstruction methods and their extensions to 3D, we focus on numerical aspects that improve reconstruction performance, which is especially important in solving large equation systems in 3D iterative reconstruction. Finally exemplary results are shown to review the properties of the discussed algorithms. (orig.)

Conditions for reliable time-resolved dosimetry of electronic portal imaging devices for fixed-gantry IMRT and VMAT

International Nuclear Information System (INIS)

Yeo, Inhwan Jason; Patyal, Baldev; Mandapaka, Anant; Jung, Jae Won; Yi, Byong Yong; Kim, Jong Oh

2013-01-01

Purpose: The continuous scanning mode of electronic portal imaging devices (EPID) that offers time-resolved information has been newly explored for verifying dynamic radiation deliveries. This study seeks to determine operating conditions (dose rate stability and time resolution) under which that mode can be used accurately for the time-resolved dosimetry of intensity-modulated radiation therapy (IMRT) beams.Methods: The authors have designed the following test beams with variable beam holdoffs and dose rate regulations: a 10 × 10 cm open beam to serve as a reference beam; a sliding window (SW) beam utilizing the motion of a pair of multileaf collimator (MLC) leaves outside the 10 × 10 cm jaw; a step and shoot (SS) beam to move the pair in step; a volumetric modulated arc therapy (VMAT) beam. The beams were designed in such a way that they all produce the same open beam output of 10 × 10 cm. Time-resolved ion chamber measurements at isocenter and time-resolved and integrating EPID measurements were performed for all beams. The time-resolved EPID measurements were evaluated through comparison with the ion chamber and integrating EPID measurements, as the latter are accepted procedures. For two-dimensional, time-resolved evaluation, a VMAT beam with an infield MLC travel was designed. Time-resolved EPID measurements and Monte Carlo calculations of such EPID dose images for this beam were performed and intercompared.Results: For IMRT beams (SW and SS), the authors found disagreement greater than 2%, caused by frame missing of the time-resolved mode. However, frame missing disappeared, yielding agreement better than 2%, when the dose rate of irradiation (and thus the frame acquisition rates) reached a stable and planned rate as the dose of irradiation was raised past certain thresholds (a minimum 12 s of irradiation per shoot used for SS IMRT). For VMAT, the authors found that dose rate does not affect the frame acquisition rate, thereby causing no frame missing

EISCAT Aperture Synthesis Imaging (EASI _3D) for the EISCAT_3D Project

Science.gov (United States)

La Hoz, Cesar; Belyey, Vasyl

2012-07-01

Aperture Synthesis Imaging Radar (ASIR) is one of the technologies adopted by the EISCAT_3D project to endow it with imaging capabilities in 3-dimensions that includes sub-beam resolution. Complemented by pulse compression, it will provide 3-dimensional images of certain types of incoherent scatter radar targets resolved to about 100 metres at 100 km range, depending on the signal-to-noise ratio. This ability will open new research opportunities to map small structures associated with non-homogeneous, unstable processes such as aurora, summer and winter polar radar echoes (PMSE and PMWE), Natural Enhanced Ion Acoustic Lines (NEIALs), structures excited by HF ionospheric heating, meteors, space debris, and others. The underlying physico-mathematical principles of the technique are the same as the technique employed in radioastronomy to image stellar objects; both require sophisticated inversion techniques to obtain reliable images.

Quantitative comparison of 2D and 3D late gadolinium enhancement MR imaging in patients with Fabry disease and hypertrophic cardiomyopathy.

Science.gov (United States)

Morsbach, F; Gordic, S; Gruner, C; Niemann, M; Goetti, R; Gotschy, A; Kozerke, S; Alkadhi, H; Manka, R

2016-08-15

This study aims to determine whether the quantification of myocardial fibrosis in patients with Fabry disease (FD) and hypertrophic cardiomyopathy (HCM) using a late gadolinium enhancement (LGE) singlebreath-hold three-dimensional (3D) inversion recovery magnetic resonance (MR) imaging sequence is comparable with a clinically established two-dimensional (2D) multi-breath-hold sequence. In this retrospective, IRB-approved study, 40 consecutive patients (18 male; mean age 50±17years) with Fabry disease (n=18) and HCM (n=22) underwent MR imaging at 1.5T. Spatial resolution was the same for 3D and 2D images (field-of-view, 350×350mm(2); in-plane-resolution, 1.2×1.2mm(2); section-thickness, 8mm). Datasets were analyzed for subjective image quality; myocardial and fibrotic mass, and total fibrotic tissue percentage were quantified. There was no significant difference in subjective image quality between 3D and 2D acquisitions (P=0.1 and P=0.3) for either disease. In patients with Fabry disease there were no significant differences between 3D and 2D acquisitions for myocardial mass (P=0.55), fibrous tissue mass (P=0.89), and total fibrous percentage (P=0.67), with good agreement between acquisitions according to Bland-Altman analyses. In patients with HCM there were also no significant differences between acquisitions for myocardial mass (P=0.48), fibrous tissue mass (P=0.56), and total fibrous percentage (P=0.67), with good agreement according to Bland-Altman analyses. Acquisition time was significantly shorter for 3D (25±5s) as compared to the 2D sequence (349±62s, P<0.001). In patients with Fabry disease and HCM, 3D LGE imaging provides equivalent diagnostic information in regard to quantification of myocardial fibrosis as compared with a standard 2D sequence, but at superior acquisition speed. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Multifractal analysis of 2D gray soil images

Science.gov (United States)

González-Torres, Ivan; Losada, Juan Carlos; Heck, Richard; Tarquis, Ana M.

2015-04-01

Soil structure, understood as the spatial arrangement of soil pores, is one of the key factors in soil modelling processes. Geometric properties of individual and interpretation of the morphological parameters of pores can be estimated from thin sections or 3D Computed Tomography images (Tarquis et al., 2003), but there is no satisfactory method to binarized these images and quantify the complexity of their spatial arrangement (Tarquis et al., 2008, Tarquis et al., 2009; Baveye et al., 2010). The objective of this work was to apply a multifractal technique, their singularities (α) and f(α) spectra, to quantify it without applying any threshold (Gónzalez-Torres, 2014). Intact soil samples were collected from four horizons of an Argisol, formed on the Tertiary Barreiras group of formations in Pernambuco state, Brazil (Itapirema Experimental Station). The natural vegetation of the region is tropical, coastal rainforest. From each horizon, showing different porosities and spatial arrangements, three adjacent samples were taken having a set of twelve samples. The intact soil samples were imaged using an EVS (now GE Medical. London, Canada) MS-8 MicroCT scanner with 45 μm pixel-1 resolution (256x256 pixels). Though some samples required paring to fit the 64 mm diameter imaging tubes, field orientation was maintained. References Baveye, P.C., M. Laba, W. Otten, L. Bouckaert, P. Dello, R.R. Goswami, D. Grinev, A. Houston, Yaoping Hu, Jianli Liu, S. Mooney, R. Pajor, S. Sleutel, A. Tarquis, Wei Wang, Qiao Wei, Mehmet Sezgin. Observer-dependent variability of the thresholding step in the quantitative analysis of soil images and X-ray microtomography data. Geoderma, 157, 51-63, 2010. González-Torres, Iván. Theory and application of multifractal analysis methods in images for the study of soil structure. Master thesis, UPM, 2014. Tarquis, A.M., R.J. Heck, J.B. Grau; J. Fabregat, M.E. Sanchez and J.M. Antón. Influence of Thresholding in Mass and Entropy Dimension of 3-D

Performance evaluation of 2D image registration algorithms with the numeric image registration and comparison platform

International Nuclear Information System (INIS)

Gerganov, G.; Kuvandjiev, V.; Dimitrova, I.; Mitev, K.; Kawrakow, I.

2012-01-01

The objective of this work is to present the capabilities of the NUMERICS web platform for evaluation of the performance of image registration algorithms. The NUMERICS platform is a web accessible tool which provides access to dedicated numerical algorithms for registration and comparison of medical images (http://numerics.phys.uni-sofia.bg). The platform allows comparison of noisy medical images by means of different types of image comparison algorithms, which are based on statistical tests for outliers. The platform also allows 2D image registration with different techniques like Elastic Thin-Plate Spline registration, registration based on rigid transformations, affine transformations, as well as non-rigid image registration based on Mobius transformations. In this work we demonstrate how the platform can be used as a tool for evaluation of the quality of the image registration process. We demonstrate performance evaluation of a deformable image registration technique based on Mobius transformations. The transformations are applied with appropriate cost functions like: Mutual information, Correlation coefficient, Sum of Squared Differences. The accent is on the results provided by the platform to the user and their interpretation in the context of the performance evaluation of 2D image registration. The NUMERICS image registration and image comparison platform provides detailed statistical information about submitted image registration jobs and can be used to perform quantitative evaluation of the performance of different image registration techniques. (authors)

Usefulness of time-resolved projection MRA on evaluation of hemodynamics in cerebral occlusive diseases

International Nuclear Information System (INIS)

Oka, Yoshihisa; Kusunoki, Katsusuke; Nochide, Ichiro; Igase, Keiji; Harada, Hironobu; Sadamoto, Kazuhiko; Nagasawa, Kiyoshi

2001-01-01

The usefulness for evaluation of cerebral hemodynamics using time-resolved projection MRA was studied in normal volunteers and patients of cerebrovascular diseases. Six normal volunteers and ten patients with cerebrovascular occlusive diseases including 6 of IC occlusion and 4 of post EC/IC bypass surgery underwent time-resolved projection MRA on a 1.5 T clinical MRI system. Projection angiograms are acquired with 2D-fast SPGR sequence with a time resolution of approximately one image per second, 40 images being acquired consecutively before and after bolus injection Gd-DTPA. And all images were calculated by complex subtraction from the background mask in a work station. In normal volunteers, the quality of images of time-resolved projection MRA was satisfactory. The arteries from internal carotid artery through M2 segment of middle cerebral artery and all major venous systems were well portrayed. In 4 cases of IC occlusion who were assessed the collateral flow through the anterior communicating artery and posterior communicating artery, there were delayed to demonstrate the ipsilateral MCA. However, in 2 cases of IC occlusion that were assessed the collateral flow through leptomeningeal anastomosis, ipsilateral MCA and collateral circulation were not demonstrated. In all patients of post EC/IC bypass surgery, the patency of EC/IC bypass could be evaluated as properly with time-resolved projection MRA as 3D-TOF MRA. Although the temporal and spatial resolutions are insufficient, time-resolved projection MRA was power-full non-invasive method to evaluate the cerebral hemodynamics vis the basal communicating arteries in IC occlusion and identify the patency of EC/IC bypass. (author)

Restoration of three-dimensional MR images degraded by rotational movements

International Nuclear Information System (INIS)

Wood, M.L.

1990-01-01

This paper describes a method to restore three-dimensional (3D) magnetic resonance (MR) images that have been degraded by rotational movements, such as head nodding by a restless patient. The technique for acquiring the 3D MR images includes additional MR signals, which provide one-dimensional (1D) and two-dimensional (2D) projections of anatomy. The 1D projections detect gross movements, and the 2D projections resolve displacements in one plane. The 2D projections are transformed from Cartesian coordinates to polar coordinates to identify rotation. A spatial transformation to reverse the rotation is applied to the imaging data after they have been Fourier transformed to resolve structures in the plane of rotation, but before the Fourier transform for the third direction

Image Quality Assessment of 2D versus 3D T2WI and Evaluation of Ultra-high b-Value (b=2,000 mm/s2) DWI for Response Assessment in Rectal Cancer.

Science.gov (United States)

Hausmann, Daniel; Liu, Jing; Budjan, Johannes; Reichert, Miriam; Ong, Melissa; Meyer, Mathias; Smakic, Arman; Grimm, Robert; Strecker, Ralph; Schoenberg, Stefan O; Wang, Xiaoying; Attenberger, Ulrike I

2018-02-01

The purpose of this IRB-approved, retrospective study was to compare image quality between 2D and high-resolution 3D, T2-weighted (T2WI) magnetic resonance imaging (MRI) sequences and to investigate the additional value of ultra-high b-value diffusion-weighted imaging (DWI; b=2,000 mm/s 2 ) for both rectal cancer staging and evaluating treatment response. From 12 February to 24 August 2016, 26 consecutive patients (22 males, four females; mean age: 61.9±14.0 years) with histologically-proven rectal cancer. In total 31 examinations [12 prior to and 19 after chemoradiation (CRT)] were included. The patients underwent pelvic MRI on a 3.0-T scanner (Magnetom Skyra, Erlangen, Germany). Three radiologists (3, 4, and 5 years of experience in MRI, respectively) independently assessed all images and rated the image quality of DWI (b=800 mm/s 2 ), apparent diffusion coefficient map, DWI (b=2,000 mm/s 2 ), 3D sagittal T2WI, 3D axial T2WI, 2D sagittal T2WI, and 2D axial T2WI of each patient, respectively. In addition, signal intensity ratios (SIR) were calculated between rectal cancer and obturator internus muscle (background) in all patients after CRT on DWI (b=2,000 mm/s 2 ) and correlated with histopathological regression grade (RG). Tumor delineation was significantly better by 2D T2WI than 3D T2WI both before and after CRT (before CRT: Z=-3.2, p=0.02; after CRT: Z=-4.408, p3D sagittal: 4.00±0.48; 2D sagittal: 4.03±0.34, p=0.713; 3D axial: 3.85±0.61, 2D axial: 3.78±0.64, p=0.537). Independent t-test showed significantly higher SIR between those with RG 1 or 2 (moderate response: mean score=2.02) and those with RG 3+4 (good response: mean score=0.8) (t=3.044, p=0.011). In those with RG 4 (complete response), SIR of b2000 was 0.946 compared to a 1.41 average of the whole cohort. In two patients, tumor was invisible on b2000 following CRT (RG 3 and 4, respectively). Interobserver agreement was mostly good (κ≥0.6) regarding image quality assessment, except for poor

Calibration model of a dual gain flat panel detector for 2D and 3D x-ray imaging

International Nuclear Information System (INIS)

Schmidgunst, C.; Ritter, D.; Lang, E.

2007-01-01

The continuing research and further development in flat panel detector technology have led to its integration into more and more medical x-ray systems for two-dimensional (2D) and three-dimensional (3D) imaging, such as fixed or mobile C arms. Besides the obvious advantages of flat panel detectors, like the slim design and the resulting optimum accessibility to the patient, their success is primarily a product of the image quality that can be achieved. The benefits in the physical and performance-related features as opposed to conventional image intensifier systems (e.g., distortion-free reproduction of imaging information or almost linear signal response over a large dynamic range) can be fully exploited, however, only if the raw detector images are correctly calibrated and postprocessed. Previous procedures for processing raw data contain idealizations that, in the real world, lead to artifacts or losses in image quality. Thus, for example, temperature dependencies or changes in beam geometry, as can occur with mobile C arm systems, have not been taken into account up to this time. Additionally, adverse characteristics such as image lag or aging effects have to be compensated to attain the best possible image quality. In this article a procedure is presented that takes into account the important dependencies of the individual pixel sensitivity of flat panel detectors used in 2D or 3D imaging and simultaneously minimizes the work required for an extensive recalibration. It is suitable for conventional detectors with only one gain mode as well as for the detectors specially developed for 3D imaging with dual gain read-out technology

Reactor safety issues resolved by the 2D/3D Program

International Nuclear Information System (INIS)

Damerell, P.S.; Simons, J.W.

1993-07-01

The 2D/3D Program studied multidimensional thermal-hydraulics in a PWR core and primary system during the end-of-blowdown and post-blowdown phases of a large-break LOCA (LBLOCA), and during selected small-break LOCA (SBLOCA) transients. The program included tests at the Cylindrical Core Test Facility (CCTF), the Slab Core Test Facility (SCTF), and the Upper Plenum Test Facility (UPTF), and computer analyses using TRAC. Tests at CCTF investigated core thermal-hydraulics and overall system behavior while tests at SCTF concentrated on multidimensional core thermal-hydraulics. The UPTF tests investigated two-phase flow behavior in the downcomer, upper plenum, tie plate region, and primary loops. TRAC analyses evaluated thermal-hydraulic behavior throughout the primary system in tests as well as in PWRs. This report summarizes the test and analysis results in each of the main areas where improved information was obtained in the 2D/3D Program. The discussion is organized in terms of the reactor safety issues investigated

Visual grading of 2D and 3D functional MRI compared with image-based descriptive measures

Energy Technology Data Exchange (ETDEWEB)

Ragnehed, Mattias [Linkoeping University, Division of Radiological Sciences, Radiology, IMH, Linkoeping (Sweden); Linkoeping University, Center for Medical Image Science and Visualization, CMIV, Linkoeping (Sweden); Linkoeping University, Department of Medical and Health Sciences, Division of Radiological Sciences/Radiology, Faculty of Health Sciences, Linkoeping (Sweden); Leinhard, Olof Dahlqvist; Pihlsgaard, Johan; Lundberg, Peter [Linkoeping University, Center for Medical Image Science and Visualization, CMIV, Linkoeping (Sweden); Linkoeping University, Division of Radiological Sciences, Radiation Physics, IMH, Linkoeping (Sweden); Wirell, Staffan [Linkoeping University, Division of Radiological Sciences, Radiology, IMH, Linkoeping (Sweden); Linkoeping University Hospital, Department of Radiology, Linkoeping (Sweden); Soekjer, Hannibal; Faegerstam, Patrik [Linkoeping University Hospital, Department of Radiology, Linkoeping (Sweden); Jiang, Bo [Linkoeping University, Center for Medical Image Science and Visualization, CMIV, Linkoeping (Sweden); Smedby, Oerjan; Engstroem, Maria [Linkoeping University, Division of Radiological Sciences, Radiology, IMH, Linkoeping (Sweden); Linkoeping University, Center for Medical Image Science and Visualization, CMIV, Linkoeping (Sweden)

2010-03-15

A prerequisite for successful clinical use of functional magnetic resonance imaging (fMRI) is the selection of an appropriate imaging sequence. The aim of this study was to compare 2D and 3D fMRI sequences using different image quality assessment methods. Descriptive image measures, such as activation volume and temporal signal-to-noise ratio (TSNR), were compared with results from visual grading characteristics (VGC) analysis of the fMRI results. Significant differences in activation volume and TSNR were not directly reflected by differences in VGC scores. The results suggest that better performance on descriptive image measures is not always an indicator of improved diagnostic quality of the fMRI results. In addition to descriptive image measures, it is important to include measures of diagnostic quality when comparing different fMRI data acquisition methods. (orig.)

Finite-element-method (FEM model generation of time-resolved 3D echocardiographic geometry data for mitral-valve volumetry

Directory of Open Access Journals (Sweden)

Kikinis Ron

2006-03-01

Full Text Available Abstract Introduction Mitral Valve (MV 3D structural data can be easily obtained using standard transesophageal echocardiography (TEE devices but quantitative pre- and intraoperative volume analysis of the MV is presently not feasible in the cardiac operation room (OR. Finite element method (FEM modelling is necessary to carry out precise and individual volume analysis and in the future will form the basis for simulation of cardiac interventions. Method With the present retrospective pilot study we describe a method to transfer MV geometric data to 3D Slicer 2 software, an open-source medical visualization and analysis software package. A newly developed software program (ROIExtract allowed selection of a region-of-interest (ROI from the TEE data and data transformation for use in 3D Slicer. FEM models for quantitative volumetric studies were generated. Results ROI selection permitted the visualization and calculations required to create a sequence of volume rendered models of the MV allowing time-based visualization of regional deformation. Quantitation of tissue volume, especially important in myxomatous degeneration can be carried out. Rendered volumes are shown in 3D as well as in time-resolved 4D animations. Conclusion The visualization of the segmented MV may significantly enhance clinical interpretation. This method provides an infrastructure for the study of image guided assessment of clinical findings and surgical planning. For complete pre- and intraoperative 3D MV FEM analysis, three input elements are necessary: 1. time-gated, reality-based structural information, 2. continuous MV pressure and 3. instantaneous tissue elastance. The present process makes the first of these elements available. Volume defect analysis is essential to fully understand functional and geometrical dysfunction of but not limited to the valve. 3D Slicer was used for semi-automatic valve border detection and volume-rendering of clinical 3D echocardiographic

Bi-dimensional arrays of SPAD for time-resolved single photon imaging

International Nuclear Information System (INIS)

Tudisco, S.; Lanzano, L.; Musumeci, F.; Neri, L.; Privitera, S.; Scordino, A.; Condorelli, G.; Fallica, G.; Mazzillo, M.; Sanfilippo, D.; Valvo, G.

2009-01-01

Many scientific areas like astronomy, biophysics, biomedicine, nuclear and plasma science, etc. are interested in the development of a new time-resolved single photon imaging device. Such a device represents today one of the most challenging goals in the field of photonics. In collaboration with Catania R and D staff of ST-Microelectronics (STM) we created, during the last few years, a new avalanche photosensor-Single Photon Avalanche Diode (SPAD) able to detect and count, with excellent performance, single photons. Further we will discuss the possible realization of a single photon imaging device through the many elements integration (bi-dimensional arrays) of SPADs. In order to achieve the goal, it is also important to develop an appropriate readout strategy able to address the time information of each individual sensor and in order to read a great number of elements easily. First prototypes were designed and manufactured by STM and the results are reported here. In the paper we will discuss in particular: (i) sensor performance (gain, photodetection efficiency, timing, after-pulsing, etc.); (ii) array performance (layout, cross-talk, etc.); (iii) readout strategy (quenching, electronics), and (iv) first imaging results (general performance).

Injectable Colloidal Gold for Use in Intrafractional 2D Image-Guided Radiation Therapy

DEFF Research Database (Denmark)

Jølck, Rasmus Irming; Rydhog, Jonas S.; Christensen, Anders Nymark

2015-01-01

radio-opacity, which allows for marker-based image guidance in 2D and 3D X-ray imaging during radiation therapy. This is achieved by surface-engineering gold nanoparticles to be highly compatible with a carbohydrate-based gelation matrix. The new fiducial marker is investigated in mice where...

Precipitation Processes Developed During ARM (1997), TOGA COARE (1992), GATE (1974), SCSMEX (1998), and KWAJEX (1999): Consistent 2D, Semi-3D and 3D Cloud Resolving Model Simulations

Science.gov (United States)

Tao, W-K.

2003-01-01

Real clouds and cloud systems are inherently three-dimensional (3D). Because of the limitations in computer resources, however, most cloud-resolving models (CRMs) today are still two-dimensional (2D). A few 3D CRMs have been used to study the response of clouds to large-scale forcing. In these 3D simulations, the model domain was small, and the integration time was 6 hours. Only recently have 3D experiments been performed for multi-day periods for tropical cloud systems with large horizontal domains at the National Center for Atmospheric Research (NACAR) and at NASA Goddard Space Flight Center . At Goddard, a 3D Goddard Cumulus Ensemble (GCE) model was used to simulate periods during TOGA COARE, SCSMEX and KWAJEX using 512 by 512 km domain (with 2 km resolution). The results indicate that surface precipitation and latent heating profiles are very similar between the 2D and 3D GCE model simulations. The reason for the strong similarity between the 2D and 3D CRM simulations is that the same observed large-scale advective tendencies of potential temperature, water vapor mixing ratio, and horizontal momentum were used as the main focusing in both the 2D and 3D models. Interestingly, the 2D and 3D versions of the CRM used at CSU showed significant differences in the rainfall and cloud statistics for three ARM cases. The major objectives of this paper are: (1) to assess the performance of the super-parameterization technique, (2) calculate and examine the surface energy (especially radiation) and water budgets, and (3) identify the differences and similarities in the organization and entrainment rates of convection between simulated 2D and 3D cloud systems.

Externally calibrated parallel imaging for 3D multispectral imaging near metallic implants using broadband ultrashort echo time imaging.

Science.gov (United States)

Wiens, Curtis N; Artz, Nathan S; Jang, Hyungseok; McMillan, Alan B; Reeder, Scott B

2017-06-01

To develop an externally calibrated parallel imaging technique for three-dimensional multispectral imaging (3D-MSI) in the presence of metallic implants. A fast, ultrashort echo time (UTE) calibration acquisition is proposed to enable externally calibrated parallel imaging techniques near metallic implants. The proposed calibration acquisition uses a broadband radiofrequency (RF) pulse to excite the off-resonance induced by the metallic implant, fully phase-encoded imaging to prevent in-plane distortions, and UTE to capture rapidly decaying signal. The performance of the externally calibrated parallel imaging reconstructions was assessed using phantoms and in vivo examples. Phantom and in vivo comparisons to self-calibrated parallel imaging acquisitions show that significant reductions in acquisition times can be achieved using externally calibrated parallel imaging with comparable image quality. Acquisition time reductions are particularly large for fully phase-encoded methods such as spectrally resolved fully phase-encoded three-dimensional (3D) fast spin-echo (SR-FPE), in which scan time reductions of up to 8 min were obtained. A fully phase-encoded acquisition with broadband excitation and UTE enabled externally calibrated parallel imaging for 3D-MSI, eliminating the need for repeated calibration regions at each frequency offset. Significant reductions in acquisition time can be achieved, particularly for fully phase-encoded methods like SR-FPE. Magn Reson Med 77:2303-2309, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

TH-EF-BRA-11: Feasibility of Super-Resolution Time-Resolved 4DMRI for Multi-Breath Volumetric Motion Simulation in Radiotherapy Planning

Energy Technology Data Exchange (ETDEWEB)

Li, G; Zakian, K; Deasy, J [Memorial Sloan Kettering Cancer Center, New York, NY (United States); Wei, J [City College of New York, New York, NY (United States); Hunt, M [Mem Sloan-Kettering Cancer Ctr, New York, NY (United States)

2016-06-15

Purpose: To develop a novel super-resolution time-resolved 4DMRI technique to evaluate multi-breath, irregular and complex organ motion without respiratory surrogate for radiotherapy planning. Methods: The super-resolution time-resolved (TR) 4DMRI approach combines a series of low-resolution 3D cine MRI images acquired during free breathing (FB) with a high-resolution breath-hold (BH) 3DMRI via deformable image registration (DIR). Five volunteers participated in the study under an IRB-approved protocol. The 3D cine images with voxel size of 5×5×5 mm{sup 3} at two volumes per second (2Hz) were acquired coronally using a T1 fast field echo sequence, half-scan (0.8) acceleration, and SENSE (3) parallel imaging. Phase-encoding was set in the lateral direction to minimize motion artifacts. The BH image with voxel size of 2×2×2 mm{sup 3} was acquired using the same sequence within 10 seconds. A demons-based DIR program was employed to produce super-resolution 2Hz 4DMRI. Registration quality was visually assessed using difference images between TR 4DMRI and 3D cine and quantitatively assessed using average voxel correlation. The fidelity of the 3D cine images was assessed using a gel phantom and a 1D motion platform by comparing mobile and static images. Results: Owing to voxel intensity similarity using the same MRI scanning sequence, accurate DIR between FB and BH images is achieved. The voxel correlations between 3D cine and TR 4DMRI are greater than 0.92 in all cases and the difference images illustrate minimal residual error with little systematic patterns. The 3D cine images of the mobile gel phantom preserve object geometry with minimal scanning artifacts. Conclusion: The super-resolution time-resolved 4DMRI technique has been achieved via DIR, providing a potential solution for multi-breath motion assessment. Accurate DIR mapping has been achieved to map high-resolution BH images to low-resolution FB images, producing 2Hz volumetric high-resolution 4DMRI

Imaging by Electrochemical Scanning Tunneling Microscopy and Deconvolution Resolving More Details of Surfaces Nanomorphology

DEFF Research Database (Denmark)

Andersen, Jens Enevold Thaulov

observed in high-resolution images of metallic nanocrystallites may be effectively deconvoluted, as to resolve more details of the crystalline morphology (see figure). Images of surface-crystalline metals indicate that more than a single atomic layer is involved in mediating the tunneling current......Upon imaging, electrochemical scanning tunneling microscopy (ESTM), scanning electrochemical micro-scopy (SECM) and in situ STM resolve information on electronic structures and on surface topography. At very high resolution, imaging processing is required, as to obtain information that relates...... to crystallographic-surface structures. Within the wide range of new technologies, those images surface features, the electrochemical scanning tunneling microscope (ESTM) provides means of atomic resolution where the tip participates actively in the process of imaging. Two metallic surfaces influence ions trapped...

3-D Imaging using Row–Column-Addressed 2-D Arrays with a Diverging Lens: Phantom Study

DEFF Research Database (Denmark)

Bouzari, Hamed; Engholm, Mathias; Beers, Christopher

2017-01-01

A double-curved diverging lens over a flat row– column-addressed (RCA) 2-D array can extend its inherent rectilinear 3-D imaging field-of-view (FOV) to a curvilinear volume region, which is necessary for applications such as abdominal and cardiac imaging. A concave lens with radius of 12.7 mm...... was manufactured using RTV664 silicone. The diverging properties of the lens were evaluated based on measurements on several phantoms. The measured 6 dB FOV in contact with a material similar to human soft tissue was less than 15% different from the theoretical predictions, i.e., a curvilinear FOV of 32...

Reactor safety issues resolved by the 2D/3D program

International Nuclear Information System (INIS)

1995-09-01

The 2D/3D Program studied multidimensional thermal-hydraulics in a PWR core and primary system during the end-of-blowdown and post-blowdown phases of a large-break LOCA (LBLOCA), and during selected small-break LOCA (SBLOCA) transients. The program included tests at the Cylindrical Core Test Facility (CCTF), the Slab Core Test Facility (SCTF), and the Upper Plenum Test Facility (UPTF), and computer analyses using TRAC. Tests at CCTF investigated core thermal-hydraulics and overall system behavior while tests at SCTF concentrated on multidimensional core thermal-hydraulics. The UPTF tests investigated two-phase flow behavior in the downcomer, upper plenum, tie plate region, and primary loops. TRAC analyses evaluated thermal-hydraulic behavior throughout the primary system in tests as well as in PWRs. This report summarizes the test and analysis results in each of the main areas where improved information was obtained in the 2D/3D Program. The discussion is organized in terms of the reactor safety issues investigated. This report was prepared in a coordination among US, Germany and Japan. US and Germany have published the report as NUREG/IA-0127 and GRS-101 respectively. (author)

Reactor safety issues resolved by the 2D/3D program

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-01

The 2D/3D Program studied multidimensional thermal-hydraulics in a PWR core and primary system during the end-of-blowdown and post-blowdown phases of a large-break LOCA (LBLOCA), and during selected small-break LOCA (SBLOCA) transients. The program included tests at the Cylindrical Core Test Facility (CCTF), the Slab Core Test Facility (SCTF), and the Upper Plenum Test Facility (UPTF), and computer analyses using TRAC. Tests at CCTF investigated core thermal-hydraulics and overall system behavior while tests at SCTF concentrated on multidimensional core thermal-hydraulics. The UPTF tests investigated two-phase flow behavior in the downcomer, upper plenum, tie plate region, and primary loops. TRAC analyses evaluated thermal-hydraulic behavior throughout the primary system in tests as well as in PWRs. This report summarizes the test and analysis results in each of the main areas where improved information was obtained in the 2D/3D Program. The discussion is organized in terms of the reactor safety issues investigated. This report was prepared in a coordination among US, Germany and Japan. US and Germany have published the report as NUREG/IA-0127 and GRS-101 respectively. (author).

Least Square NUFFT Methods Applied to 2D and 3D Radially Encoded MR Image Reconstruction

Science.gov (United States)

Song, Jiayu; Liu, Qing H.; Gewalt, Sally L.; Cofer, Gary; Johnson, G. Allan

2009-01-01

Radially encoded MR imaging (MRI) has gained increasing attention in applications such as hyperpolarized gas imaging, contrast-enhanced MR angiography, and dynamic imaging, due to its motion insensitivity and improved artifact properties. However, since the technique collects k-space samples nonuniformly, multidimensional (especially 3D) radially sampled MRI image reconstruction is challenging. The balance between reconstruction accuracy and speed becomes critical when a large data set is processed. Kaiser-Bessel gridding reconstruction has been widely used for non-Cartesian reconstruction. The objective of this work is to provide an alternative reconstruction option in high dimensions with on-the-fly kernels calculation. The work develops general multi-dimensional least square nonuniform fast Fourier transform (LS-NUFFT) algorithms and incorporates them into a k-space simulation and image reconstruction framework. The method is then applied to reconstruct the radially encoded k-space, although the method addresses general nonuniformity and is applicable to any non-Cartesian patterns. Performance assessments are made by comparing the LS-NUFFT based method with the conventional Kaiser-Bessel gridding method for 2D and 3D radially encoded computer simulated phantoms and physically scanned phantoms. The results show that the LS-NUFFT reconstruction method has better accuracy-speed efficiency than the Kaiser-Bessel gridding method when the kernel weights are calculated on the fly. The accuracy of the LS-NUFFT method depends on the choice of scaling factor, and it is found that for a particular conventional kernel function, using its corresponding deapodization function as scaling factor and utilizing it into the LS-NUFFT framework has the potential to improve accuracy. When a cosine scaling factor is used, in particular, the LS-NUFFT method is faster than Kaiser-Bessel gridding method because of a quasi closed-form solution. The method is successfully applied to 2D and

3-D portal image analysis in clinical practice: an evaluation of 2-D and 3-D analysis techniques as applied to 30 prostate cancer patients

International Nuclear Information System (INIS)

Remeijer, Peter; Geerlof, Erik; Ploeger, Lennert; Gilhuijs, Kenneth; Herk, Marcel van; Lebesque, Joos V.

2000-01-01

Purpose: To investigate the clinical importance and feasibility of a 3-D portal image analysis method in comparison with a standard 2-D portal image analysis method for pelvic irradiation techniques. Methods and Materials: In this study, images of 30 patients who were treated for prostate cancer were used. A total of 837 imaged fields were analyzed by a single technologist, using automatic 2-D and 3-D techniques independently. Standard deviations (SDs) of the random, systematic, and overall variations, and the overall mean were calculated for the resulting data sets (2-D and 3-D), in the three principal directions (left-right [L-R], cranial-caudal [C-C], anterior-posterior [A-P]). The 3-D analysis included rotations as well. For the translational differences between the three data sets, the overall SD and overall mean were computed. The influence of out-of-plane rotations on the 2-D registration accuracy was determined by analyzing the difference between the 2-D and 3-D translation data as function of rotations. To assess the reliability of the 2-D and 3-D methods, the number of times the automatic match was manually adjusted was counted. Finally, an estimate of the workload was made. Results: The SDs of the random and systematic components of the rotations around the three orthogonal axes were 1.1 (L-R), 0.6 (C-C), 0.5 (A-P) and 0.9 (L-R), 0.6 (C-C), 0.8 (A-P) degrees, respectively. The overall mean rotation around the L-R axis was 0.7 deg., which deviated significantly from zero. Translational setup errors were comparable for 2-D and 3-D analysis (ranging from 1.4 to 2.2 mm SD and from 1.5 to 2.5 mm SD, respectively). The variation of the difference between the 2-D and 3-D translation data increased from 1.1 mm (SD) for zero rotations to 2.7 mm (SD) for out-of-plane rotations of 3 deg., due to a reduced 2-D registration accuracy for large rotations. The number of times the analysis was not considered acceptable and was manually adjusted was 44% for the 2-D

High-resolution high-sensitivity elemental imaging by secondary ion mass spectrometry: from traditional 2D and 3D imaging to correlative microscopy

International Nuclear Information System (INIS)

Wirtz, T; Philipp, P; Audinot, J-N; Dowsett, D; Eswara, S

2015-01-01

Secondary ion mass spectrometry (SIMS) constitutes an extremely sensitive technique for imaging surfaces in 2D and 3D. Apart from its excellent sensitivity and high lateral resolution (50 nm on state-of-the-art SIMS instruments), advantages of SIMS include high dynamic range and the ability to differentiate between isotopes. This paper first reviews the underlying principles of SIMS as well as the performance and applications of 2D and 3D SIMS elemental imaging. The prospects for further improving the capabilities of SIMS imaging are discussed. The lateral resolution in SIMS imaging when using the microprobe mode is limited by (i) the ion probe size, which is dependent on the brightness of the primary ion source, the quality of the optics of the primary ion column and the electric fields in the near sample region used to extract secondary ions; (ii) the sensitivity of the analysis as a reasonable secondary ion signal, which must be detected from very tiny voxel sizes and thus from a very limited number of sputtered atoms; and (iii) the physical dimensions of the collision cascade determining the origin of the sputtered ions with respect to the impact site of the incident primary ion probe. One interesting prospect is the use of SIMS-based correlative microscopy. In this approach SIMS is combined with various high-resolution microscopy techniques, so that elemental/chemical information at the highest sensitivity can be obtained with SIMS, while excellent spatial resolution is provided by overlaying the SIMS images with high-resolution images obtained by these microscopy techniques. Examples of this approach are given by presenting in situ combinations of SIMS with transmission electron microscopy (TEM), helium ion microscopy (HIM) and scanning probe microscopy (SPM). (paper)

Reconstructing 3D profiles of flux distribution in array of unshunted Josephson junctions from 2D scanning SQUID microscope images

International Nuclear Information System (INIS)

Nascimento, F.M.; Sergeenkov, S.; Araujo-Moreira, F.M.

2012-01-01

By using a specially designed algorithm (based on utilizing the so-called Hierarchical Data Format), we report on successful reconstruction of 3D profiles of local flux distribution within artificially prepared arrays of unshunted Nb-AlO x -Nb Josephson junctions from 2D surface images obtained via the scanning SQUID microscope. The analysis of the obtained results suggest that for large sweep areas, the local flux distribution significantly deviates from the conventional picture and exhibits a more complicated avalanche-type behavior with a prominent dendritic structure. -- Highlights: ► The penetration of external magnetic field into an array of Nb-AlO x -Nb Josephson junctions is studied. ► Using Scanning SQUID Microscope, 2D images of local flux distribution within array are obtained. ► Using specially designed pattern recognition algorithm, 3D flux profiles are reconstructed from 2D images.

Time-resolved pH/pO2 mapping with luminescent hybrid sensors.

Science.gov (United States)

Schröder, Claudia R; Polerecky, Lubos; Klimant, Ingo

2007-01-01

A method for simultaneous and referenced 2D mapping of pH and pO2 is described. The experimental setup combines a fast gateable CCD camera as detector, a LED as excitation light source and a single-layer sensor membrane as optical transducer. The planar optode comprises a lipophilic fluorescein derivative (lifetime approximately 5 ns) and platinum(II) mesotetrakis(pentafluorophenyl)porphyrin (approximately 70 micros in the absence of a quencher) immobilized in a hydrogel matrix. Depending on the fluorescent pH indicator, a pH transition in the physiological range (pH 6-pH 8) or in the near-basic region (pH 7-pH 9) can be achieved. The measuring scheme involves the time-resolved acquisition of images in three windows during a series of square-shaped excitation pulses. A method allowing the calculation of both parameters from these three images is presented. The pH/pO2 hybrid sensor incorporating the pH indicator 2',7'-dihexyl-5(6)-N-octadecyl-carboxamidofluorescein was characterized in detail. The pH and pO2 were determined with a maximum deviation of 0.03 pH unit and 6.5 hPa pO2, respectively, within the range of pH 7.6-pH 8.7 and 0-200 hPa pO2 in test measurements. The ionic strength (IS) cross-sensitivity was found to be relatively small (pH/IS pO2/IS pO2 images obtained in natural marine sediment are presented.

3D/2D model-to-image registration by imitation learning for cardiac procedures.

Science.gov (United States)

Toth, Daniel; Miao, Shun; Kurzendorfer, Tanja; Rinaldi, Christopher A; Liao, Rui; Mansi, Tommaso; Rhode, Kawal; Mountney, Peter

2018-05-12

In cardiac interventions, such as cardiac resynchronization therapy (CRT), image guidance can be enhanced by involving preoperative models. Multimodality 3D/2D registration for image guidance, however, remains a significant research challenge for fundamentally different image data, i.e., MR to X-ray. Registration methods must account for differences in intensity, contrast levels, resolution, dimensionality, field of view. Furthermore, same anatomical structures may not be visible in both modalities. Current approaches have focused on developing modality-specific solutions for individual clinical use cases, by introducing constraints, or identifying cross-modality information manually. Machine learning approaches have the potential to create more general registration platforms. However, training image to image methods would require large multimodal datasets and ground truth for each target application. This paper proposes a model-to-image registration approach instead, because it is common in image-guided interventions to create anatomical models for diagnosis, planning or guidance prior to procedures. An imitation learning-based method, trained on 702 datasets, is used to register preoperative models to intraoperative X-ray images. Accuracy is demonstrated on cardiac models and artificial X-rays generated from CTs. The registration error was [Formula: see text] on 1000 test cases, superior to that of manual ([Formula: see text]) and gradient-based ([Formula: see text]) registration. High robustness is shown in 19 clinical CRT cases. Besides the proposed methods feasibility in a clinical environment, evaluation has shown good accuracy and high robustness indicating that it could be applied in image-guided interventions.

Registration of dynamic dopamine D2receptor images using principal component analysis

International Nuclear Information System (INIS)

Acton, P.D.; Ell, P.J.; Pilowsky, L.S.; Brammer, M.J.; Suckling, J.

1997-01-01

This paper describes a novel technique for registering a dynamic sequence of single-photon emission tomography (SPET) dopamine D 2 receptor images, using principal component analysis (PCA). Conventional methods for registering images, such as count difference and correlation coefficient algorithms, fail to take into account the dynamic nature of the data, resulting in large systematic errors when registering time-varying images. However, by using principal component analysis to extract the temporal structure of the image sequence, misregistration can be quantified by examining the distribution of eigenvalues. The registration procedures were tested using a computer-generated dynamic phantom derived from a high-resolution magnetic resonance image of a realistic brain phantom. Each method was also applied to clinical SPET images of dopamine D 2 receptors, using the ligands iodine-123 iodobenzamide and iodine-123 epidepride, to investigate the influence of misregistration on kinetic modelling parameters and the binding potential. The PCA technique gave highly significant (P 123 I-epidepride scans. The PCA method produced data of much greater quality for subsequent kinetic modelling, with an improvement of nearly 50% in the χ 2 of the fit to the compartmental model, and provided superior quality registration of particularly difficult dynamic sequences. (orig.)

ON SOFT D2-ALGEBRA AND SOFT D2-IDEALS

OpenAIRE

S. Subramanian; S. Seethalaksmi

2018-01-01

In this paper, we have studied some characterization of soft D2-algebra, kernel, intersection, image, quotient D2-algebra’s and relations ship between D2-algebra and D2-ideals with suitable examples.

2-deoxy-2[F-18]fluoro-D-mannose positron emission tomography imaging in atherosclerosis

NARCIS (Netherlands)

Tahara, Nobuhiro; Mukherjee, Jogeshwar; de Haas, Hans J; Petrov, Artiom D; Tawakol, Ahmed; Haider, Nezam; Tahara, Atsuko; Constantinescu, Cristian C; Zhou, Jun; Boersma, Hendrikus H; Imaizumi, Tsutomu; Nakano, Masataka; Finn, Aloke; Fayad, Zahi; Virmani, Renu; Fuster, Valentin; Bosca, Lisardo; Narula, Jagat

Progressive inflammation in atherosclerotic plaques is associated with increasing risk of plaque rupture. Molecular imaging of activated macrophages with 2-deoxy-2[F-18]fluoro-D-glucose ([F-18]FDG) has been proposed for identification of patients at higher risk for acute vascular events. Because

Contrast in atomically resolved EF-SCEM imaging

Energy Technology Data Exchange (ETDEWEB)

Wang, Peng [National Laboratory of Solid State Microstructures and Department of Materials Science and Engineering, Nanjing University, Nanjing 210093 (China); D’Alfonso, Adrian J. [School of Physics, University of Melbourne, Parkville, Victoria 3010 (Australia); Hashimoto, Ayako [Surface Physics and Structure Unit, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba 305-0047 (Japan); Global Research Center for Environment and Energy based on Nanomaterials Science, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, 305-0047 (Japan); Electron Microscopy Station, National Institute for Materials Science, 3-13 Sakura, Tsukuba 305-0003 (Japan); Morgan, Andrew J. [School of Physics, University of Melbourne, Parkville, Victoria 3010 (Australia); Takeguchi, Masaki [Surface Physics and Structure Unit, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba 305-0047 (Japan); Electron Microscopy Station, National Institute for Materials Science, 3-13 Sakura, Tsukuba 305-0003 (Japan); Mitsuishi, Kazutaka [Surface Physics and Structure Unit, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba 305-0047 (Japan); Global Research Center for Environment and Energy based on Nanomaterials Science, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, 305-0047 (Japan); Electron Microscopy Station, National Institute for Materials Science, 3-13 Sakura, Tsukuba 305-0003 (Japan); Shimojo, Masayuki [Department of Materials Science and Engineering, Shibaura Institute of Technology, 3-7-5, Toyosu, Koto-ku, Tokyo, 135-8548 (Japan); Kirkland, Angus I. [Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH (United Kingdom); Allen, Leslie J. [School of Physics, University of Melbourne, Parkville, Victoria 3010 (Australia); Nellist, Peter D., E-mail: peter.nellist@materials.ox.ac.uk [Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH (United Kingdom)

2013-11-15

Energy-filtered scanning confocal electron microscopy (EF-SCEM) is a technique that uses the reduced depth of field of an aberration-corrected transmission electron microscope to provide three-dimensional (3D) compositional information. Using a silicon sample in the <110> orientation, we show that EF-SCEM image data can be recorded that shows lattice resolution in the plane perpendicular to the incident beam direction. The confocal effect is demonstrated through the reduction of the mean intensity as the confocal plane is displaced from the sample mid-plane, unlike optical sectioning in high-angle annular dark-field scanning transmission electron microscopy (STEM). Simulations of the EF-SCEM data show agreement with the experimental data, and allow the interpretability of the data to be explored. The effects of channelling, absorption and delocalisation complicate the quantitative and qualitative interpretation of the data, highlighting the need for matching to simulations. Finally the effects of the finite detector pin-hole aperture size are explored, and we show that the EF-SCEM contrast in the plane perpendicular to the beam direction starts to resemble that of a STEM spectrum imaging experiment as the aperture size increases. - Highlights: • Atomically resolved energy-filtered scanning confocal electron microscopy (EF-SCEM) is demonstrated. • The confocal effect is demonstrated through the reduction of the mean intensity as the confocal plane is displaced from the sample mid-plane. • Simulations show agreement with the experimental data. • The effects of channelling, absorption and delocalisation complicate the quantitative and qualitative interpretation of the data. • The effects of the finite detector pin-hole aperture size are explored.

Contrast in atomically resolved EF-SCEM imaging

International Nuclear Information System (INIS)

Wang, Peng; D’Alfonso, Adrian J.; Hashimoto, Ayako; Morgan, Andrew J.; Takeguchi, Masaki; Mitsuishi, Kazutaka; Shimojo, Masayuki; Kirkland, Angus I.; Allen, Leslie J.; Nellist, Peter D.

2013-01-01

Energy-filtered scanning confocal electron microscopy (EF-SCEM) is a technique that uses the reduced depth of field of an aberration-corrected transmission electron microscope to provide three-dimensional (3D) compositional information. Using a silicon sample in the orientation, we show that EF-SCEM image data can be recorded that shows lattice resolution in the plane perpendicular to the incident beam direction. The confocal effect is demonstrated through the reduction of the mean intensity as the confocal plane is displaced from the sample mid-plane, unlike optical sectioning in high-angle annular dark-field scanning transmission electron microscopy (STEM). Simulations of the EF-SCEM data show agreement with the experimental data, and allow the interpretability of the data to be explored. The effects of channelling, absorption and delocalisation complicate the quantitative and qualitative interpretation of the data, highlighting the need for matching to simulations. Finally the effects of the finite detector pin-hole aperture size are explored, and we show that the EF-SCEM contrast in the plane perpendicular to the beam direction starts to resemble that of a STEM spectrum imaging experiment as the aperture size increases. - Highlights: • Atomically resolved energy-filtered scanning confocal electron microscopy (EF-SCEM) is demonstrated. • The confocal effect is demonstrated through the reduction of the mean intensity as the confocal plane is displaced from the sample mid-plane. • Simulations show agreement with the experimental data. • The effects of channelling, absorption and delocalisation complicate the quantitative and qualitative interpretation of the data. • The effects of the finite detector pin-hole aperture size are explored

SU-E-J-13: Six Degree of Freedom Image Fusion Accuracy for Cranial Target Localization On the Varian Edge Stereotactic Radiosurgery System: Comparison Between 2D/3D and KV CBCT Image Registration

Energy Technology Data Exchange (ETDEWEB)

Xu, H [Wayne State University, Detroit, MI (United States); Song, K; Chetty, I; Kim, J [Henry Ford Health System, Detroit, MI (United States); Wen, N [Henry Ford Health System, West Bloomfield, MI (United States)

2015-06-15

Purpose: To determine the 6 degree of freedom systematic deviations between 2D/3D and CBCT image registration with various imaging setups and fusion algorithms on the Varian Edge Linac. Methods: An anthropomorphic head phantom with radio opaque targets embedded was scanned with CT slice thicknesses of 0.8, 1, 2, and 3mm. The 6 DOF systematic errors were assessed by comparing 2D/3D (kV/MV with CT) with 3D/3D (CBCT with CT) image registrations with different offset positions, similarity measures, image filters, and CBCT slice thicknesses (1 and 2 mm). The 2D/3D registration accuracy of 51 fractions for 26 cranial SRS patients was also evaluated by analyzing 2D/3D pre-treatment verification taken after 3D/3D image registrations. Results: The systematic deviations of 2D/3D image registration using kV- kV, MV-kV and MV-MV image pairs were within ±0.3mm and ±0.3° for translations and rotations with 95% confidence interval (CI) for a reference CT with 0.8 mm slice thickness. No significant difference (P>0.05) on target localization was observed between 0.8mm, 1mm, and 2mm CT slice thicknesses with CBCT slice thicknesses of 1mm and 2mm. With 3mm CT slice thickness, both 2D/3D and 3D/3D registrations performed less accurately in longitudinal direction than thinner CT slice thickness (0.60±0.12mm and 0.63±0.07mm off, respectively). Using content filter and using similarity measure of pattern intensity instead of mutual information, improved the 2D/3D registration accuracy significantly (P=0.02 and P=0.01, respectively). For the patient study, means and standard deviations of residual errors were 0.09±0.32mm, −0.22±0.51mm and −0.07±0.32mm in VRT, LNG and LAT directions, respectively, and 0.12°±0.46°, −0.12°±0.39° and 0.06°±0.28° in RTN, PITCH, and ROLL directions, respectively. 95% CI of translational and rotational deviations were comparable to those in phantom study. Conclusion: 2D/3D image registration provided on the Varian Edge radiosurgery, 6 DOF

SU-E-J-13: Six Degree of Freedom Image Fusion Accuracy for Cranial Target Localization On the Varian Edge Stereotactic Radiosurgery System: Comparison Between 2D/3D and KV CBCT Image Registration

International Nuclear Information System (INIS)

Xu, H; Song, K; Chetty, I; Kim, J; Wen, N

2015-01-01

Purpose: To determine the 6 degree of freedom systematic deviations between 2D/3D and CBCT image registration with various imaging setups and fusion algorithms on the Varian Edge Linac. Methods: An anthropomorphic head phantom with radio opaque targets embedded was scanned with CT slice thicknesses of 0.8, 1, 2, and 3mm. The 6 DOF systematic errors were assessed by comparing 2D/3D (kV/MV with CT) with 3D/3D (CBCT with CT) image registrations with different offset positions, similarity measures, image filters, and CBCT slice thicknesses (1 and 2 mm). The 2D/3D registration accuracy of 51 fractions for 26 cranial SRS patients was also evaluated by analyzing 2D/3D pre-treatment verification taken after 3D/3D image registrations. Results: The systematic deviations of 2D/3D image registration using kV- kV, MV-kV and MV-MV image pairs were within ±0.3mm and ±0.3° for translations and rotations with 95% confidence interval (CI) for a reference CT with 0.8 mm slice thickness. No significant difference (P>0.05) on target localization was observed between 0.8mm, 1mm, and 2mm CT slice thicknesses with CBCT slice thicknesses of 1mm and 2mm. With 3mm CT slice thickness, both 2D/3D and 3D/3D registrations performed less accurately in longitudinal direction than thinner CT slice thickness (0.60±0.12mm and 0.63±0.07mm off, respectively). Using content filter and using similarity measure of pattern intensity instead of mutual information, improved the 2D/3D registration accuracy significantly (P=0.02 and P=0.01, respectively). For the patient study, means and standard deviations of residual errors were 0.09±0.32mm, −0.22±0.51mm and −0.07±0.32mm in VRT, LNG and LAT directions, respectively, and 0.12°±0.46°, −0.12°±0.39° and 0.06°±0.28° in RTN, PITCH, and ROLL directions, respectively. 95% CI of translational and rotational deviations were comparable to those in phantom study. Conclusion: 2D/3D image registration provided on the Varian Edge radiosurgery, 6 DOF

2D Geoelectric Imaging of the Uneme-Nekhua Fracture Zone

Directory of Open Access Journals (Sweden)

Muslim B. Aminu

2014-01-01

Full Text Available We have employed 2D geoelectric imaging to reveal the geometry and nature of a fracture zone in Uneme-Nekhua, southwestern Nigeria. The fracture zone is discernable from an outcropping rock scarp and appears to define the course of a seasonal stream. Data were acquired using the dipole-dipole survey array configuration with electrode separation of 6 m and a maximum dipole length of 60 m. Three traverses with lengths varying between 72 m and 120 m were laid orthogonal to the course of the seasonal stream. 2D geoelectric images of the subsurface along the profiles imaged a north-south trending fracture zone. This fracture zone appears to consist of two vertical fractures with more intense definition downstream. The eastern fracture is buried by recent sediment, while the western fracture appears to have experienced more recent tectonic activity as it appears to penetrate through the near surface. Perhaps at some point, deformation ceased on the eastern fracture and further strain was transferred to the western fracture. The fracture zone generally defines the course of the north-south seasonal stream with the exception of the downstream end where the fracture appears to have died out entirely. Two associated basement trenches lying parallel to and east of the fracture zone are also imaged.

Time- and energy resolved photoemission electron microscopy-imaging of photoelectron time-of-flight analysis by means of pulsed excitations

International Nuclear Information System (INIS)

Oelsner, Andreas; Rohmer, Martin; Schneider, Christian; Bayer, Daniela; Schoenhense, Gerd; Aeschlimann, Martin

2010-01-01

The present work enlightens the developments in time- and energy resolved photoemission electron microscopy over the past few years. We describe basic principles of the technique and demonstrate different applications. An energy- and time-filtering photoemission electron microscopy (PEEM) for real-time spectroscopic imaging can be realized either by a retarding field or hemispherical energy analyzer or by using time-of-flight optics with a delay line detector. The latter method has the advantage of no data loss at all as all randomly incoming particles are measured not only by position but also by time. This is of particular interest for pump-probe experiments in the femtosecond and attosecond time scale where space charge processes drastically limit the maximum number of photoemitted electrons per laser pulse. This work focuses particularly on time-of-flight analysis using a novel delay line detector. Time and energy resolved PEEM instruments with delay line detectors enable 4D imaging (x, y, Δt, E Kin ) on a true counting basis. This allows a broad range of applications from real-time observation of dynamic phenomena at surfaces to fs time-of-flight spectro-microscopy and even aberration correction. By now, these time-of-flight analysis instruments achieve intrinsic time resolutions of 108 ps absolute and 13.5 ps relative. Very high permanent measurement speeds of more than 4 million events per second in random detection regimes have been realized using a standard USB2.0 interface. By means of this performance, the time-resolved PEEM technique enables to display evolutions of spatially resolved (<25 nm) and temporal sliced images life on any modern computer. The method allows dynamics investigations of variable electrical, magnetic, and optical near fields at surfaces and great prospects in dynamical adaptive photoelectron optics. For dynamical processes in the ps time scale such as magnetic domain wall movements, the time resolution of the delay line detectors

Time-resolved tomographic images of a relativistic electron beam

International Nuclear Information System (INIS)

Koehler, H.A.; Jacoby, B.A.; Nelson, M.

1984-07-01

We obtained a sequential series of time-resolved tomographic two-dimensional images of a 4.5-MeV, 6-kA, 30-ns electron beam. Three linear fiber-optic arrays of 30 or 60 fibers each were positioned around the beam axis at 0 0 , 61 0 , and 117 0 . The beam interacting with nitrogen at 20 Torr emitted light that was focused onto the fiber arrays and transmitted to a streak camera where the data were recorded on film. The film was digitized, and two-dimensional images were reconstructed using the maximum-entropy tomographic technique. These images were then combined to produce an ultra-high-speed movie of the electron-beam pulse

Site-resolved imaging of a bosonic Mott insulator using ytterbium atoms

Science.gov (United States)

Miranda, Martin; Inoue, Ryotaro; Tambo, Naoki; Kozuma, Mikio

2017-10-01

We demonstrate site-resolved imaging of a strongly correlated quantum system without relying on laser cooling techniques during fluorescence imaging. We observe the formation of Mott shells in the insulating regime and realize thermometry in an atomic cloud. This work proves the feasibility of the noncooled approach and opens the door to extending the detection technology to new atomic species.

An integrated circuit with transmit beamforming flip-chip bonded to a 2-D CMUT array for 3-D ultrasound imaging.

Science.gov (United States)

Wygant, Ira O; Jamal, Nafis S; Lee, Hyunjoo J; Nikoozadeh, Amin; Oralkan, Omer; Karaman, Mustafa; Khuri-Yakub, Butrus T

2009-10-01

State-of-the-art 3-D medical ultrasound imaging requires transmitting and receiving ultrasound using a 2-D array of ultrasound transducers with hundreds or thousands of elements. A tight combination of the transducer array with integrated circuitry eliminates bulky cables connecting the elements of the transducer array to a separate system of electronics. Furthermore, preamplifiers located close to the array can lead to improved receive sensitivity. A combined IC and transducer array can lead to a portable, high-performance, and inexpensive 3-D ultrasound imaging system. This paper presents an IC flip-chip bonded to a 16 x 16-element capacitive micromachined ultrasonic transducer (CMUT) array for 3-D ultrasound imaging. The IC includes a transmit beamformer that generates 25-V unipolar pulses with programmable focusing delays to 224 of the 256 transducer elements. One-shot circuits allow adjustment of the pulse widths for different ultrasound transducer center frequencies. For receiving reflected ultrasound signals, the IC uses the 32-elements along the array diagonals. The IC provides each receiving element with a low-noise 25-MHz-bandwidth transimpedance amplifier. Using a field-programmable gate array (FPGA) clocked at 100 MHz to operate the IC, the IC generated properly timed transmit pulses with 5-ns accuracy. With the IC flip-chip bonded to a CMUT array, we show that the IC can produce steered and focused ultrasound beams. We present 2-D and 3-D images of a wire phantom and 2-D orthogonal cross-sectional images (Bscans) of a latex heart phantom.

Synchronized 2D/3D optical mapping for interactive exploration and real-time visualization of multi-function neurological images.

Science.gov (United States)

Zhang, Qi; Alexander, Murray; Ryner, Lawrence

2013-01-01

Efficient software with the ability to display multiple neurological image datasets simultaneously with full real-time interactivity is critical for brain disease diagnosis and image-guided planning. In this paper, we describe the creation and function of a new comprehensive software platform that integrates novel algorithms and functions for multiple medical image visualization, processing, and manipulation. We implement an opacity-adjustment algorithm to build 2D lookup tables for multiple slice image display and fusion, which achieves a better visual result than those of using VTK-based methods. We also develop a new real-time 2D and 3D data synchronization scheme for multi-function MR volume and slice image optical mapping and rendering simultaneously through using the same adjustment operation. All these methodologies are integrated into our software framework to provide users with an efficient tool for flexibly, intuitively, and rapidly exploring and analyzing the functional and anatomical MR neurological data. Finally, we validate our new techniques and software platform with visual analysis and task-specific user studies. Copyright © 2013 Elsevier Ltd. All rights reserved.

High resolution 3D imaging of synchrotron generated microbeams

Energy Technology Data Exchange (ETDEWEB)

Gagliardi, Frank M., E-mail: frank.gagliardi@wbrc.org.au [Alfred Health Radiation Oncology, The Alfred, Melbourne, Victoria 3004, Australia and School of Medical Sciences, RMIT University, Bundoora, Victoria 3083 (Australia); Cornelius, Iwan [Imaging and Medical Beamline, Australian Synchrotron, Clayton, Victoria 3168, Australia and Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales 2500 (Australia); Blencowe, Anton [Division of Health Sciences, School of Pharmacy and Medical Sciences, The University of South Australia, Adelaide, South Australia 5000, Australia and Division of Information Technology, Engineering and the Environment, Mawson Institute, University of South Australia, Mawson Lakes, South Australia 5095 (Australia); Franich, Rick D. [School of Applied Sciences and Health Innovations Research Institute, RMIT University, Melbourne, Victoria 3000 (Australia); Geso, Moshi [School of Medical Sciences, RMIT University, Bundoora, Victoria 3083 (Australia)

2015-12-15

Purpose: Microbeam radiation therapy (MRT) techniques are under investigation at synchrotrons worldwide. Favourable outcomes from animal and cell culture studies have proven the efficacy of MRT. The aim of MRT researchers currently is to progress to human clinical trials in the near future. The purpose of this study was to demonstrate the high resolution and 3D imaging of synchrotron generated microbeams in PRESAGE® dosimeters using laser fluorescence confocal microscopy. Methods: Water equivalent PRESAGE® dosimeters were fabricated and irradiated with microbeams on the Imaging and Medical Beamline at the Australian Synchrotron. Microbeam arrays comprised of microbeams 25–50 μm wide with 200 or 400 μm peak-to-peak spacing were delivered as single, cross-fire, multidirectional, and interspersed arrays. Imaging of the dosimeters was performed using a NIKON A1 laser fluorescence confocal microscope. Results: The spatial fractionation of the MRT beams was clearly visible in 2D and up to 9 mm in depth. Individual microbeams were easily resolved with the full width at half maximum of microbeams measured on images with resolutions of as low as 0.09 μm/pixel. Profiles obtained demonstrated the change of the peak-to-valley dose ratio for interspersed MRT microbeam arrays and subtle variations in the sample positioning by the sample stage goniometer were measured. Conclusions: Laser fluorescence confocal microscopy of MRT irradiated PRESAGE® dosimeters has been validated in this study as a high resolution imaging tool for the independent spatial and geometrical verification of MRT beam delivery.

High resolution 3D imaging of synchrotron generated microbeams

International Nuclear Information System (INIS)

Gagliardi, Frank M.; Cornelius, Iwan; Blencowe, Anton; Franich, Rick D.; Geso, Moshi

2015-01-01

Purpose: Microbeam radiation therapy (MRT) techniques are under investigation at synchrotrons worldwide. Favourable outcomes from animal and cell culture studies have proven the efficacy of MRT. The aim of MRT researchers currently is to progress to human clinical trials in the near future. The purpose of this study was to demonstrate the high resolution and 3D imaging of synchrotron generated microbeams in PRESAGE® dosimeters using laser fluorescence confocal microscopy. Methods: Water equivalent PRESAGE® dosimeters were fabricated and irradiated with microbeams on the Imaging and Medical Beamline at the Australian Synchrotron. Microbeam arrays comprised of microbeams 25–50 μm wide with 200 or 400 μm peak-to-peak spacing were delivered as single, cross-fire, multidirectional, and interspersed arrays. Imaging of the dosimeters was performed using a NIKON A1 laser fluorescence confocal microscope. Results: The spatial fractionation of the MRT beams was clearly visible in 2D and up to 9 mm in depth. Individual microbeams were easily resolved with the full width at half maximum of microbeams measured on images with resolutions of as low as 0.09 μm/pixel. Profiles obtained demonstrated the change of the peak-to-valley dose ratio for interspersed MRT microbeam arrays and subtle variations in the sample positioning by the sample stage goniometer were measured. Conclusions: Laser fluorescence confocal microscopy of MRT irradiated PRESAGE® dosimeters has been validated in this study as a high resolution imaging tool for the independent spatial and geometrical verification of MRT beam delivery

RESOLVE: A new algorithm for aperture synthesis imaging of extended emission in radio astronomy

Science.gov (United States)

Junklewitz, H.; Bell, M. R.; Selig, M.; Enßlin, T. A.

2016-02-01

We present resolve, a new algorithm for radio aperture synthesis imaging of extended and diffuse emission in total intensity. The algorithm is derived using Bayesian statistical inference techniques, estimating the surface brightness in the sky assuming a priori log-normal statistics. resolve estimates the measured sky brightness in total intensity, and the spatial correlation structure in the sky, which is used to guide the algorithm to an optimal reconstruction of extended and diffuse sources. During this process, the algorithm succeeds in deconvolving the effects of the radio interferometric point spread function. Additionally, resolve provides a map with an uncertainty estimate of the reconstructed surface brightness. Furthermore, with resolve we introduce a new, optimal visibility weighting scheme that can be viewed as an extension to robust weighting. In tests using simulated observations, the algorithm shows improved performance against two standard imaging approaches for extended sources, Multiscale-CLEAN and the Maximum Entropy Method.

Performance evaluation of 2D and 3D deep learning approaches for automatic segmentation of multiple organs on CT images

Science.gov (United States)

Zhou, Xiangrong; Yamada, Kazuma; Kojima, Takuya; Takayama, Ryosuke; Wang, Song; Zhou, Xinxin; Hara, Takeshi; Fujita, Hiroshi

2018-02-01

The purpose of this study is to evaluate and compare the performance of modern deep learning techniques for automatically recognizing and segmenting multiple organ regions on 3D CT images. CT image segmentation is one of the important task in medical image analysis and is still very challenging. Deep learning approaches have demonstrated the capability of scene recognition and semantic segmentation on nature images and have been used to address segmentation problems of medical images. Although several works showed promising results of CT image segmentation by using deep learning approaches, there is no comprehensive evaluation of segmentation performance of the deep learning on segmenting multiple organs on different portions of CT scans. In this paper, we evaluated and compared the segmentation performance of two different deep learning approaches that used 2D- and 3D deep convolutional neural networks (CNN) without- and with a pre-processing step. A conventional approach that presents the state-of-the-art performance of CT image segmentation without deep learning was also used for comparison. A dataset that includes 240 CT images scanned on different portions of human bodies was used for performance evaluation. The maximum number of 17 types of organ regions in each CT scan were segmented automatically and compared to the human annotations by using ratio of intersection over union (IU) as the criterion. The experimental results demonstrated the IUs of the segmentation results had a mean value of 79% and 67% by averaging 17 types of organs that segmented by a 3D- and 2D deep CNN, respectively. All the results of the deep learning approaches showed a better accuracy and robustness than the conventional segmentation method that used probabilistic atlas and graph-cut methods. The effectiveness and the usefulness of deep learning approaches were demonstrated for solving multiple organs segmentation problem on 3D CT images.

GHGSat-D: Greenhouse gas plume imaging and quantification from space using a Fabry-Perot imaging spectrometer

Science.gov (United States)

McKeever, J.; Durak, B. O. A.; Gains, D.; Jervis, D.; Varon, D. J.; Germain, S.; Sloan, J. J.

2017-12-01

GHGSat, Inc. has launched the first satellite designed to detect and quantify greenhouse gas emissions from individual industrial sites. Our demonstration satellite GHGSat-D or "CLAIRE" was launched in June 2016. It weighs less than 15 kg and its primary instrument is a miniaturized Fabry-Perot imaging spectrometer with spectral resolution on the order of 0.1 nm. The spectral bandpass is 1635-1670 nm, giving the instrument access to absorption bands of both CO2 and CH4. Our system is based on targeted observations rather than global coverage, and our spatial imaging resolution is a key differentiator. Specifically, with a ground sampling distance of effect of the Fabry-Perot resonator and the scrolling scene gives a different spectral sampling of each surface location in every image. While our data processing toolchain does not produce a conventional hyperspectral dataset, it does yield a spectral decomposition of the spatially resolved signal that is compared to a model that includes atmospheric radiative transfer and the instrument's pixel-dependent spectral responsivity. Our presentation will describe the instrument design, concept of operations and retrievals approach. We will also present images and results from GHGSat-D at different processing levels, including high-resolution column density retrievals. An observation of the degassing flux of methane from the outlet of a recently impounded hydroelectric reservoir will be shown as an example. Finally we discuss some performance limitations of GHGSat-D and our plans to overcome them as we update the instrument design for the next satellites.

Textural analyses of carbon fiber materials by 2D-FFT of complex images obtained by high frequency eddy current imaging (HF-ECI)

Science.gov (United States)

Schulze, Martin H.; Heuer, Henning

2012-04-01

Carbon fiber based materials are used in many lightweight applications in aeronautical, automotive, machine and civil engineering application. By the increasing automation in the production process of CFRP laminates a manual optical inspection of each resin transfer molding (RTM) layer is not practicable. Due to the limitation to surface inspection, the quality parameters of multilayer 3 dimensional materials cannot be observed by optical systems. The Imaging Eddy- Current (EC) NDT is the only suitable inspection method for non-resin materials in the textile state that allows an inspection of surface and hidden layers in parallel. The HF-ECI method has the capability to measure layer displacements (misaligned angle orientations) and gap sizes in a multilayer carbon fiber structure. EC technique uses the variation of the electrical conductivity of carbon based materials to obtain material properties. Beside the determination of textural parameters like layer orientation and gap sizes between rovings, the detection of foreign polymer particles, fuzzy balls or visualization of undulations can be done by the method. For all of these typical parameters an imaging classification process chain based on a high resolving directional ECimaging device named EddyCus® MPECS and a 2D-FFT with adapted preprocessing algorithms are developed.

3D vector flow imaging

DEFF Research Database (Denmark)

Pihl, Michael Johannes

The main purpose of this PhD project is to develop an ultrasonic method for 3D vector flow imaging. The motivation is to advance the field of velocity estimation in ultrasound, which plays an important role in the clinic. The velocity of blood has components in all three spatial dimensions, yet...... are (vx, vy, vz) = (-0.03, 95, 1.0) ± (9, 6, 1) cm/s compared with the expected (0, 96, 0) cm/s. Afterwards, 3D vector flow images from a cross-sectional plane of the vessel are presented. The out of plane velocities exhibit the expected 2D circular-symmetric parabolic shape. The experimental results...... verify that the 3D TO method estimates the complete 3D velocity vectors, and that the method is suitable for 3D vector flow imaging....

Analysis of students’ spatial thinking in geometry: 3D object into 2D representation

Science.gov (United States)

Fiantika, F. R.; Maknun, C. L.; Budayasa, I. K.; Lukito, A.

2018-05-01

The aim of this study is to find out the spatial thinking process of students in transforming 3-dimensional (3D) object to 2-dimensional (2D) representation. Spatial thinking is helpful in using maps, planning routes, designing floor plans, and creating art. The student can engage geometric ideas by using concrete models and drawing. Spatial thinking in this study is identified through geometrical problems of transforming a 3-dimensional object into a 2-dimensional object image. The problem was resolved by the subject and analyzed by reference to predetermined spatial thinking indicators. Two representative subjects of elementary school were chosen based on mathematical ability and visual learning style. Explorative description through qualitative approach was used in this study. The result of this study are: 1) there are different representations of spatial thinking between a boy and a girl object, 2) the subjects has their own way to invent the fastest way to draw cube net.

Effects of x-ray and CT image enhancements on the robustness and accuracy of a rigid 3D/2D image registration

International Nuclear Information System (INIS)

Kim, Jinkoo; Yin Fangfang; Zhao Yang; Kim, Jae Ho

2005-01-01

A rigid body three-dimensional/two-dimensional (3D/2D) registration method has been implemented using mutual information, gradient ascent, and 3D texturemap-based digitally reconstructed radiographs. Nine combinations of commonly used x-ray and computed tomography (CT) image enhancement methods, including window leveling, histogram equalization, and adaptive histogram equalization, were examined to assess their effects on accuracy and robustness of the registration method. From a set of experiments using an anthropomorphic chest phantom, we were able to draw several conclusions. First, the CT and x-ray preprocessing combination with the widest attraction range was the one that linearly stretched the histograms onto the entire display range on both CT and x-ray images. The average attraction ranges of this combination were 71.3 mm and 61.3 deg in the translation and rotation dimensions, respectively, and the average errors were 0.12 deg and 0.47 mm. Second, the combination of the CT image with tissue and bone information and the x-ray images with adaptive histogram equalization also showed subvoxel accuracy, especially the best in the translation dimensions. However, its attraction ranges were the smallest among the examined combinations (on average 36 mm and 19 deg). Last the bone-only information on the CT image did not show convergency property to the correct registration

D3D augmented reality imaging system: proof of concept in mammography

Directory of Open Access Journals (Sweden)

Douglas DB

2016-08-01

Full Text Available David B Douglas,1 Emanuel F Petricoin,2 Lance Liotta,2 Eugene Wilson3 1Department of Radiology, Stanford University, Palo Alto, CA, 2Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, 3Department of Radiology, Fort Benning, Columbus, GA, USA Purpose: The purpose of this article is to present images from simulated breast microcalcifications and assess the pattern of the microcalcifications with a technical development called “depth 3-dimensional (D3D augmented reality”. Materials and methods: A computer, head display unit, joystick, D3D augmented reality software, and an in-house script of simulated data of breast microcalcifications in a ductal distribution were used. No patient data was used and no statistical analysis was performed. Results: The D3D augmented reality system demonstrated stereoscopic depth perception by presenting a unique image to each eye, focal point convergence, head position tracking, 3D cursor, and joystick fly-through. Conclusion: The D3D augmented reality imaging system offers image viewing with depth perception and focal point convergence. The D3D augmented reality system should be tested to determine its utility in clinical practice. Keywords: augmented reality, 3D medical imaging, radiology, depth perception

Thermally activated delayed fluorescence of fluorescein derivative for time-resolved and confocal fluorescence imaging.

Science.gov (United States)

Xiong, Xiaoqing; Song, Fengling; Wang, Jingyun; Zhang, Yukang; Xue, Yingying; Sun, Liangliang; Jiang, Na; Gao, Pan; Tian, Lu; Peng, Xiaojun

2014-07-09

Compared with fluorescence imaging utilizing fluorophores whose lifetimes are in the order of nanoseconds, time-resolved fluorescence microscopy has more advantages in monitoring target fluorescence. In this work, compound DCF-MPYM, which is based on a fluorescein derivative, showed long-lived luminescence (22.11 μs in deaerated ethanol) and was used in time-resolved fluorescence imaging in living cells. Both nanosecond time-resolved transient difference absorption spectra and time-correlated single-photon counting (TCSPC) were employed to explain the long lifetime of the compound, which is rare in pure organic fluorophores without rare earth metals and heavy atoms. A mechanism of thermally activated delayed fluorescence (TADF) that considers the long wavelength fluorescence, large Stokes shift, and long-lived triplet state of DCF-MPYM was proposed. The energy gap (ΔEST) of DCF-MPYM between the singlet and triplet state was determined to be 28.36 meV by the decay rate of DF as a function of temperature. The ΔE(ST) was small enough to allow efficient intersystem crossing (ISC) and reverse ISC, leading to efficient TADF at room temperature. The straightforward synthesis of DCF-MPYM and wide availability of its starting materials contribute to the excellent potential of the compound to replace luminescent lanthanide complexes in future time-resolved imaging technologies.

Measurement of left atrial volume by 2D and 3D non-contrast computed tomography compared with cardiac magnetic resonance imaging

DEFF Research Database (Denmark)

Fredgart, Maise Høigaard; Carter-Storch, Rasmus; Møller, Jacob Eifer

2018-01-01

Background: Cardiac magnetic resonance imaging (MRI) is considered the gold standard for assessment of left atrial (LA) volume. We assessed the feasibility of evaluating LA volume using 3D non-contrast computed tomography (NCCT). Furthermore, since manual tracing of LA volume is time consuming, we...... evaluated the accuracy of the LA area using 2D NCCT imaging for LA volume assessment. Methods: MRI and NCCT imaging were performed in 69 patients before and one year after aortic valve replacement. In 3D MRI and 3D NCCT, each slice was manually traced, excluding the pulmonary veins and atrial appendage...

Effects of intra-operative fluoroscopic 3D-imaging on peri-operative imaging strategy in calcaneal fracture surgery.

Science.gov (United States)

Beerekamp, M S H; Backes, M; Schep, N W L; Ubbink, D T; Luitse, J S; Schepers, T; Goslings, J C

2017-12-01

Previous studies demonstrated that intra-operative fluoroscopic 3D-imaging (3D-imaging) in calcaneal fracture surgery is promising to prevent revision surgery and save costs. However, these studies limited their focus to corrections performed after 3D-imaging, thereby neglecting corrections after intra-operative fluoroscopic 2D-imaging (2D-imaging). The aim of this study was to assess the effects of additional 3D-imaging on intra-operative corrections, peri-operative imaging used, and patient-relevant outcomes compared to 2D-imaging alone. In this before-after study, data of adult patients who underwent open reduction and internal fixation (ORIF) of a calcaneal fracture between 2000 and 2014 in our level-I Trauma center were collected. 3D-imaging (BV Pulsera with 3D-RX, Philips Healthcare, Best, The Netherlands) was available as of 2007 at the surgeons' discretion. Patient and fracture characteristics, peri-operative imaging, intra-operative corrections and patient-relevant outcomes were collected from the hospital databases. Patients in whom additional 3D-imaging was applied were compared to those undergoing 2D-imaging alone. A total of 231 patients were included of whom 107 (46%) were operated with the use of 3D-imaging. No significant differences were found in baseline characteristics. The median duration of surgery was significantly longer when using 3D-imaging (2:08 vs. 1:54 h; p = 0.002). Corrections after additional 3D-imaging were performed in 53% of the patients. However, significantly fewer corrections were made after 2D-imaging when 3D-imaging was available (Risk difference (RD) -15%; 95% Confidence interval (CI) -29 to -2). Peri-operative imaging, besides intra-operative 3D-imaging, and patient-relevant outcomes were similar between groups. Intra-operative 3D-imaging provides additional information resulting in additional corrections. Moreover, 3D-imaging probably changed the surgeons' attitude to rely more on 3D-imaging, hence a 15%-decrease of

2D Doppler backscattering using synthetic aperture microwave imaging of MAST edge plasmas

Science.gov (United States)

Thomas, D. A.; Brunner, K. J.; Freethy, S. J.; Huang, B. K.; Shevchenko, V. F.; Vann, R. G. L.

2016-02-01

Doppler backscattering (DBS) is already established as a powerful diagnostic; its extension to 2D enables imaging of turbulence characteristics from an extended region of the cut-off surface. The Synthetic Aperture Microwave Imaging (SAMI) diagnostic has conducted proof-of-principle 2D DBS experiments of MAST edge plasma. SAMI actively probes the plasma edge using a wide (±40° vertical and horizontal) and tuneable (10-34.5 GHz) beam. The Doppler backscattered signal is digitised in vector form using an array of eight Vivaldi PCB antennas. This allows the receiving array to be focused in any direction within the field of view simultaneously to an angular range of 6-24° FWHM at 10-34.5 GHz. This capability is unique to SAMI and is a novel way of conducting DBS experiments. In this paper the feasibility of conducting 2D DBS experiments is explored. Initial observations of phenomena previously measured by conventional DBS experiments are presented; such as momentum injection from neutral beams and an abrupt change in power and turbulence velocity coinciding with the onset of H-mode. In addition, being able to carry out 2D DBS imaging allows a measurement of magnetic pitch angle to be made; preliminary results are presented. Capabilities gained through steering a beam using a phased array and the limitations of this technique are discussed.

Nonlaser-based 3D surface imaging

Energy Technology Data Exchange (ETDEWEB)

Lu, Shin-yee; Johnson, R.K.; Sherwood, R.J. [Lawrence Livermore National Lab., CA (United States)

1994-11-15

3D surface imaging refers to methods that generate a 3D surface representation of objects of a scene under viewing. Laser-based 3D surface imaging systems are commonly used in manufacturing, robotics and biomedical research. Although laser-based systems provide satisfactory solutions for most applications, there are situations where non laser-based approaches are preferred. The issues that make alternative methods sometimes more attractive are: (1) real-time data capturing, (2) eye-safety, (3) portability, and (4) work distance. The focus of this presentation is on generating a 3D surface from multiple 2D projected images using CCD cameras, without a laser light source. Two methods are presented: stereo vision and depth-from-focus. Their applications are described.

A quantitative damage imaging technique based on enhanced CCRTM for composite plates using 2D scan

Science.gov (United States)

He, Jiaze; Yuan, Fuh-Gwo

2016-10-01

A two-dimensional (2D) non-contact areal scan system was developed to image and quantify impact damage in a composite plate using an enhanced zero-lag cross-correlation reverse-time migration (E-CCRTM) technique. The system comprises a single piezoelectric wafer mounted on the composite plate and a laser Doppler vibrometer (LDV) for scanning a region in the vicinity of the PZT to capture the scattered wavefield. The proposed damage imaging technique takes into account the amplitude, phase, geometric spreading, and all of the frequency content of the Lamb waves propagating in the plate; thus, a reflectivity coefficients of the delamination is calculated and potentially related to damage severity. Comparisons are made in terms of damage imaging quality between 2D areal scans and 1D line scans as well as between the proposed and existing imaging conditions. The experimental results show that the 2D E-CCRTM performs robustly when imaging and quantifying impact damage in large-scale composites using a single PZT actuator with a nearby areal scan using LDV.

Geological Structures Mapping of Bukit Bunuh using 2-D Resistivity Imaging Method

Science.gov (United States)

Nur Amalina, M. K. A.; Nordiana, M. M.; Rahman, Nazrin; Saidin, Mokhtar; Masnan, S. S. K.

2018-04-01

The geological area of Bukit Bunuh is very complex due to the meteorite impact that has occurred millions years ago at Lenggong, Perak. The lithology of the study area consists of alluvium, tephra dust, and granitic rock. The geological contact, fault and fracture zone were found at the study area may indicate the geological process that undergoes at a place locally or regionally. These important features have led to the further research on 2-D resistivity imaging method (2-D RIM) to study the geological features. This method can provide the subsurface image that will delineate the geological structures. The surveys include three separate lines of different length which depend on the accessibility. The surveys were done by using Pole-Dipole array and 10 m of electrodes spacing. The objectives of this research are to determine the subsurface geological contact and to determine the existence of fault/fracture zones at the contact zone. The results from 2-D inversion profiles have successfully signified the types of geological structural such as fault, contact, and fractures. Hence, the results from 2-D RIM were used to draw the geological lineaments of Bukit Bunuh. The discontinuity of the lineaments may indicate the structures present.

3D super-resolution imaging with blinking quantum dots

Science.gov (United States)

Wang, Yong; Fruhwirth, Gilbert; Cai, En; Ng, Tony; Selvin, Paul R.

2013-01-01

Quantum dots are promising candidates for single molecule imaging due to their exceptional photophysical properties, including their intense brightness and resistance to photobleaching. They are also notorious for their blinking. Here we report a novel way to take advantage of quantum dot blinking to develop an imaging technique in three-dimensions with nanometric resolution. We first applied this method to simulated images of quantum dots, and then to quantum dots immobilized on microspheres. We achieved imaging resolutions (FWHM) of 8–17 nm in the x-y plane and 58 nm (on coverslip) or 81 nm (deep in solution) in the z-direction, approximately 3–7 times better than what has been achieved previously with quantum dots. This approach was applied to resolve the 3D distribution of epidermal growth factor receptor (EGFR) molecules at, and inside of, the plasma membrane of resting basal breast cancer cells. PMID:24093439

Registration of dynamic dopamine D{sub 2}receptor images using principal component analysis

Energy Technology Data Exchange (ETDEWEB)

Acton, P.D.; Ell, P.J. [Institute of Nuclear Medicine, University College London Medical School, London (United Kingdom); Pilowsky, L.S.; Brammer, M.J. [Institute of Psychiatry, De Crespigny Park, London (United Kingdom); Suckling, J. [Clinical Age Research Unit, Kings College School of Medicine and Dentistry, London (United Kingdom)

1997-11-01

This paper describes a novel technique for registering a dynamic sequence of single-photon emission tomography (SPET) dopamine D{sub 2}receptor images, using principal component analysis (PCA). Conventional methods for registering images, such as count difference and correlation coefficient algorithms, fail to take into account the dynamic nature of the data, resulting in large systematic errors when registering time-varying images. However, by using principal component analysis to extract the temporal structure of the image sequence, misregistration can be quantified by examining the distribution of eigenvalues. The registration procedures were tested using a computer-generated dynamic phantom derived from a high-resolution magnetic resonance image of a realistic brain phantom. Each method was also applied to clinical SPET images of dopamine D {sub 2}receptors, using the ligands iodine-123 iodobenzamide and iodine-123 epidepride, to investigate the influence of misregistration on kinetic modelling parameters and the binding potential. The PCA technique gave highly significant (P <0.001) improvements in image registration, leading to alignment errors in x and y of about 25% of the alternative methods, with reductions in autocorrelations over time. It could also be applied to align image sequences which the other methods failed completely to register, particularly {sup 123}I-epidepride scans. The PCA method produced data of much greater quality for subsequent kinetic modelling, with an improvement of nearly 50% in the {chi}{sup 2}of the fit to the compartmental model, and provided superior quality registration of particularly difficult dynamic sequences. (orig.) With 4 figs., 2 tabs., 26 refs.

Comparison of post-contrast 3D-T1-MPRAGE, 3D-T1-SPACE and 3D-T2-FLAIR MR images in evaluation of meningeal abnormalities at 3-T MRI.

Science.gov (United States)

Jeevanandham, Balaji; Kalyanpur, Tejas; Gupta, Prashant; Cherian, Mathew

2017-06-01

This study was to assess the usefulness of newer three-dimensional (3D)-T 1 sampling perfection with application optimized contrast using different flip-angle evolutions (SPACE) and 3D-T 2 fluid-attenuated inversion recovery (FLAIR) sequences in evaluation of meningeal abnormalities. 78 patients who presented with high suspicion of meningeal abnormalities were evaluated using post-contrast 3D-T 2 -FLAIR, 3D-T 1 magnetization-prepared rapid gradient-echo (MPRAGE) and 3D-T 1 -SPACE sequences. The images were evaluated independently by two radiologists for cortical gyral, sulcal space, basal cisterns and dural enhancement. The diagnoses were confirmed by further investigations including histopathology. Post-contrast 3D-T 1 -SPACE and 3D-T 2 -FLAIR images yielded significantly more information than MPRAGE images (p evaluation of meningeal abnormalities and when used in combination have the maximum sensitivity for leptomeningeal abnormalities. The negative-predictive value is nearly 100%, where no leptomeningeal abnormality was detected on these sequences. Advances in knowledge: Post-contrast 3D-T 1 -SPACE and 3D-T 2 -FLAIR images are more useful than 3D-T 1 -MPRAGE images in evaluation of meningeal abnormalities.

Clinical applications of 2D and 3D CT imaging of the airways - a review

International Nuclear Information System (INIS)

Salvolini, Luca; Bichi Secchi, Elisabetta; Costarelli, Leonardo; De Nicola, Maurizio

2000-01-01

Hardware and software evolution has broadened the possibilities of 2D and 3D reformatting of spiral CT and MR data set. In the study of the thorax, intrinsic benefits of volumetric CT scanning and better quality of reconstructed images offer us the possibility to apply additional rendering techniques to everyday clinical practice. Considering the large number and redundancy of possible post-processing imaging techniques that we can apply to raw CT sections data, it is necessary to precisely set a well-defined number of clinical applications of each of them, by careful evaluation of their benefits and possible pitfalls in each clinical setting. In diagnostic evaluation of pathological processes affecting the airways, a huge number of thin sections is necessary for detailed appraisal and has to be evaluated, and information must then be transferred to referring clinicians. By additional rendering it is possible to make image evaluation and data transfer easier, faster, and more effective. In the study of central airways, additional rendering can be of interest for precise evaluation of the length, morphology, and degree of stenoses. It may help in depicting exactly the locoregional extent of central tumours by better display of relations with bronchovascular interfaces and can increase CT/bronchoscopy sinergy. It may allow closer radiotherapy planning and better depiction of air collections, and, finally, it could ease panoramic evaluation of the results of dynamic or functional studies, that are made possible by increased speed of spiral scanning. When applied to the evaluation of peripheral airways, as a completion to conventional HRCT scans, High-Resolution Volumetric CT, by projection slabs applied to target areas of interest, can better depict the profusion and extension of affected bronchial segments in bronchiectasis, influence the choice of different approaches for tissue sampling by better evaluation of the relations of lung nodules with the airways, or help

Clinical applications of 2D and 3D CT imaging of the airways - a review

Energy Technology Data Exchange (ETDEWEB)

Salvolini, Luca E-mail: u.salvolini@popcsi.unian.it; Bichi Secchi, Elisabetta; Costarelli, Leonardo; De Nicola, Maurizio

2000-04-01

Hardware and software evolution has broadened the possibilities of 2D and 3D reformatting of spiral CT and MR data set. In the study of the thorax, intrinsic benefits of volumetric CT scanning and better quality of reconstructed images offer us the possibility to apply additional rendering techniques to everyday clinical practice. Considering the large number and redundancy of possible post-processing imaging techniques that we can apply to raw CT sections data, it is necessary to precisely set a well-defined number of clinical applications of each of them, by careful evaluation of their benefits and possible pitfalls in each clinical setting. In diagnostic evaluation of pathological processes affecting the airways, a huge number of thin sections is necessary for detailed appraisal and has to be evaluated, and information must then be transferred to referring clinicians. By additional rendering it is possible to make image evaluation and data transfer easier, faster, and more effective. In the study of central airways, additional rendering can be of interest for precise evaluation of the length, morphology, and degree of stenoses. It may help in depicting exactly the locoregional extent of central tumours by better display of relations with bronchovascular interfaces and can increase CT/bronchoscopy sinergy. It may allow closer radiotherapy planning and better depiction of air collections, and, finally, it could ease panoramic evaluation of the results of dynamic or functional studies, that are made possible by increased speed of spiral scanning. When applied to the evaluation of peripheral airways, as a completion to conventional HRCT scans, High-Resolution Volumetric CT, by projection slabs applied to target areas of interest, can better depict the profusion and extension of affected bronchial segments in bronchiectasis, influence the choice of different approaches for tissue sampling by better evaluation of the relations of lung nodules with the airways, or help

Multi-stage 3D-2D registration for correction of anatomical deformation in image-guided spine surgery

Science.gov (United States)

Ketcha, M. D.; De Silva, T.; Uneri, A.; Jacobson, M. W.; Goerres, J.; Kleinszig, G.; Vogt, S.; Wolinsky, J.-P.; Siewerdsen, J. H.

2017-06-01

A multi-stage image-based 3D-2D registration method is presented that maps annotations in a 3D image (e.g. point labels annotating individual vertebrae in preoperative CT) to an intraoperative radiograph in which the patient has undergone non-rigid anatomical deformation due to changes in patient positioning or due to the intervention itself. The proposed method (termed msLevelCheck) extends a previous rigid registration solution (LevelCheck) to provide an accurate mapping of vertebral labels in the presence of spinal deformation. The method employs a multi-stage series of rigid 3D-2D registrations performed on sets of automatically determined and increasingly localized sub-images, with the final stage achieving a rigid mapping for each label to yield a locally rigid yet globally deformable solution. The method was evaluated first in a phantom study in which a CT image of the spine was acquired followed by a series of 7 mobile radiographs with increasing degree of deformation applied. Second, the method was validated using a clinical data set of patients exhibiting strong spinal deformation during thoracolumbar spine surgery. Registration accuracy was assessed using projection distance error (PDE) and failure rate (PDE  >  20 mm—i.e. label registered outside vertebra). The msLevelCheck method was able to register all vertebrae accurately for all cases of deformation in the phantom study, improving the maximum PDE of the rigid method from 22.4 mm to 3.9 mm. The clinical study demonstrated the feasibility of the approach in real patient data by accurately registering all vertebral labels in each case, eliminating all instances of failure encountered in the conventional rigid method. The multi-stage approach demonstrated accurate mapping of vertebral labels in the presence of strong spinal deformation. The msLevelCheck method maintains other advantageous aspects of the original LevelCheck method (e.g. compatibility with standard clinical workflow, large

Mvox: Interactive 2-4D medical image and graphics visualization software

DEFF Research Database (Denmark)

Bro-Nielsen, Morten

1996-01-01

Mvox is a new tool for visualization, segmentation and manipulation of a wide range of 2-4D grey level and colour images, and 3D surface graphics, which has been developed at the Department of Mathematical Modelling, Technical University of Denmark. The principal idea behind the software has been...... to provide a flexible tool that is able to handle all the kinds of data that are typically used in a research environment for medical imaging and visualization. At the same time the software should be easy to use and have a consistent interface providing locally only the functions relevant to the context....... This has been achieved by using Unix standards such as X/Motif/OpenGL and conforming to modern standards of interactive windowed programs...

Coupling 2D/3D registration method and statistical model to perform 3D reconstruction from partial x-rays images data.

Science.gov (United States)

Cresson, T; Chav, R; Branchaud, D; Humbert, L; Godbout, B; Aubert, B; Skalli, W; De Guise, J A

2009-01-01

3D reconstructions of the spine from a frontal and sagittal radiographs is extremely challenging. The overlying features of soft tissues and air cavities interfere with image processing. It is also difficult to obtain information that is accurate enough to reconstruct complete 3D models. To overcome these problems, the proposed method efficiently combines the partial information contained in two images from a patient with a statistical 3D spine model generated from a database of scoliotic patients. The algorithm operates through two simultaneous iterating processes. The first one generates a personalized vertebra model using a 2D/3D registration process with bone boundaries extracted from radiographs, while the other one infers the position and the shape of other vertebrae from the current estimation of the registration process using a statistical 3D model. Experimental evaluations have shown good performances of the proposed approach in terms of accuracy and robustness when compared to CT-scan.

Preliminary examples of 3D vector flow imaging

DEFF Research Database (Denmark)

Pihl, Michael Johannes; Stuart, Matthias Bo; Tomov, Borislav Gueorguiev

2013-01-01

This paper presents 3D vector flow images obtained using the 3D Transverse Oscillation (TO) method. The method employs a 2D transducer and estimates the three velocity components simultaneously, which is important for visualizing complex flow patterns. Data are acquired using the experimental ult...... as opposed to magnetic resonance imaging (MRI). The results demonstrate that the 3D TO method is capable of performing 3D vector flow imaging.......This paper presents 3D vector flow images obtained using the 3D Transverse Oscillation (TO) method. The method employs a 2D transducer and estimates the three velocity components simultaneously, which is important for visualizing complex flow patterns. Data are acquired using the experimental...... ultrasound scanner SARUS on a flow rig system with steady flow. The vessel of the flow-rig is centered at a depth of 30 mm, and the flow has an expected 2D circular-symmetric parabolic prole with a peak velocity of 1 m/s. Ten frames of 3D vector flow images are acquired in a cross-sectional plane orthogonal...

Utility of 3D Reconstruction of 2D Liver Computed Tomography/Magnetic Resonance Images as a Surgical Planning Tool for Residents in Liver Resection Surgery.

Science.gov (United States)

Yeo, Caitlin T; MacDonald, Andrew; Ungi, Tamas; Lasso, Andras; Jalink, Diederick; Zevin, Boris; Fichtinger, Gabor; Nanji, Sulaiman

A fundamental aspect of surgical planning in liver resections is the identification of key vessel tributaries to preserve healthy liver tissue while fully resecting the tumor(s). Current surgical planning relies primarily on the surgeon's ability to mentally reconstruct 2D computed tomography/magnetic resonance (CT/MR) images into 3D and plan resection margins. This creates significant cognitive load, especially for trainees, as it relies on image interpretation, anatomical and surgical knowledge, experience, and spatial sense. The purpose of this study is to determine if 3D reconstruction of preoperative CT/MR images will assist resident-level trainees in making appropriate operative plans for liver resection surgery. Ten preoperative patient CT/MR images were selected. Images were case-matched, 5 to 2D planning and 5 to 3D planning. Images from the 3D group were segmented to create interactive digital models that the resident can manipulate to view the tumor(s) in relation to landmark hepatic structures. Residents were asked to evaluate the images and devise a surgical resection plan for each image. The resident alternated between 2D and 3D planning, in a randomly generated order. The primary outcome was the accuracy of resident's plan compared to expert opinion. Time to devise each surgical plan was the secondary outcome. Residents completed a prestudy and poststudy questionnaire regarding their experience with liver surgery and the 3D planning software. Senior level surgical residents from the Queen's University General Surgery residency program were recruited to participate. A total of 14 residents participated in the study. The median correct response rate was 2 of 5 (40%; range: 0-4) for the 2D group, and 3 of 5 (60%; range: 1-5) for the 3D group (p surgery planning increases accuracy of resident surgical planning and decreases amount of time required. 3D reconstruction would be a useful model for improving trainee understanding of liver anatomy and surgical

Time-resolved investigations of the fragmentation dynamic of H{sub 2} (D{sub 2}) in and with ultra-short laser pulses; Zeitaufgeloeste Untersuchungen zur Fragmentationsdynamik von H{sub 2} (D{sub 2}) in ultra-kurzen Laserpulsen

Energy Technology Data Exchange (ETDEWEB)

Ergler, T.

2006-07-19

In course of this work pump-probe experiments aimed to study ultrafast nuclear motion in H{sub 2} (D{sub 2}) fragmentation by intense 6-25 fs laser pulses have been carried out. In order to perform time-resolved measurements, a Mach-Zehnder interferometer providing two identical synchronized laser pulses with the time-delay variable from 0 to 3000 fs with 300 as accuracy and long-term stability has been built. The laser pulses at the intensities of up to 10{sup 15} W/cm{sup 2} were focused onto a H{sub 2} (D{sub 2}) molecular beam leading to the ionization or dissociation of the molecules, and the momenta of all charged reactions fragments were measured with a reaction microscope. With 6-7 fs pulses it was possible to probe the time evolution of the bound H{sup +}{sub 2} (D{sup +}{sub 2}) nuclear wave packet created by the first (pump) laser pulse, fragmenting the molecule with the second (probe) pulse. A fast delocalization, or ''collapse'', and subsequent ''revival'' of the vibrational wave packet have been observed. In addition, the signatures of the ground state vibrational excitation in neutral D{sub 2} molecule have been found, and the dominance of a new, purely quantum mechanical wave packet preparation mechanism (the so-called ''Lochfrass'') has been proved. In the experiments with 25 fs pulses the theoretically predicted enhancement of the ionization probability for the dissociating H{sup +}{sub 2} molecular ion at large internuclear distances has been detected for the first time. (orig.)

Evaluation of a breast software model for 2D and 3D X-ray imaging studies of the breast.

Science.gov (United States)

Baneva, Yanka; Bliznakova, Kristina; Cockmartin, Lesley; Marinov, Stoyko; Buliev, Ivan; Mettivier, Giovanni; Bosmans, Hilde; Russo, Paolo; Marshall, Nicholas; Bliznakov, Zhivko

2017-09-01

In X-ray imaging, test objects reproducing breast anatomy characteristics are realized to optimize issues such as image processing or reconstruction, lesion detection performance, image quality and radiation induced detriment. Recently, a physical phantom with a structured background has been introduced for both 2D mammography and breast tomosynthesis. A software version of this phantom and a few related versions are now available and a comparison between these 3D software phantoms and the physical phantom will be presented. The software breast phantom simulates a semi-cylindrical container filled with spherical beads of different diameters. Four computational breast phantoms were generated with a dedicated software application and for two of these, physical phantoms are also available and they are used for the side by side comparison. Planar projections in mammography and tomosynthesis were simulated under identical incident air kerma conditions. Tomosynthesis slices were reconstructed with an in-house developed reconstruction software. In addition to a visual comparison, parameters like fractal dimension, power law exponent β and second order statistics (skewness, kurtosis) of planar projections and tomosynthesis reconstructed images were compared. Visually, an excellent agreement between simulated and real planar and tomosynthesis images is observed. The comparison shows also an overall very good agreement between parameters evaluated from simulated and experimental images. The computational breast phantoms showed a close match with their physical versions. The detailed mathematical analysis of the images confirms the agreement between real and simulated 2D mammography and tomosynthesis images. The software phantom is ready for optimization purpose and extrapolation of the phantom to other breast imaging techniques. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Quantitative Comparison of 2D and 3D MRI Techniques for the Evaluation of Chondromalacia Patellae in 3.0T MR Imaging of the Knee

Directory of Open Access Journals (Sweden)

Ali Özgen

2016-09-01

Full Text Available INTRODUCTION: Chondromalacia patellae is a very common disorder of patellar cartilage. Magnetic resonance imaging (MRI is a powerful non-invasive tool to investigate patellar cartilage lesions. Although many MRI sequences have been used in MR imaging of the patellar cartilage and the optimal pulse sequence is controversial, fat-saturated proton density images have been considered very valuable to evaluate patellar cartilage. The purpose of this study is to quantitatively compare the diagnostic performance of various widely used 2D and 3D MRI techniques for the evaluation of chondromalacia patellae in 3.0T MR imaging of the knee using T2 mapping images as the reference standard. METHODS: Sevety-five knee MRI exams of 69 adult consecutive were included in the study. Fat-saturated T2-weighted (FST2, fat-saturated proton density (FSPD, water-only T2-weighted DIXON (T2mD, T2-weighted 3 dimensional steady state (3DT2FFE, merged multi-echo steady state (3DmFFE, and water selective T1-weighted fat-supressed (WATSc images were acquired. Quantitative comparison of grade 1 and grade 5 lesions were made using contrast-to-noise (CNR ratios. Grade 2-4 lesions were scored qualitatively and scorings of the lesions were compared statistically. Analysis of variance and Tukey’s tests were used to compare CNR data. Two sample z-test was used to compare the ratio of MR exams positive for grade 1 lesions noted on T2-mapping and other conventional sequences. Paired samples t-test was used to compare two different pulse sequences. RESULTS: In detecting grade 1 lesions, FSPD, FST2 and T2mD images were superior in comparison to other sequences. FSPD and FST2 images were statistically superior in detecting grade 2-4 lesions. Although all grade 5 lesions were noted in every single sequence, FST2 images have the highest mean CNR followed by 3DT2FFE images. DISCUSSION AND CONCLUSION: FST2 sequence is equal or superior in detecting every grade of patellar chondromalacia in

2D-Driven 3D Object Detection in RGB-D Images

KAUST Repository

Lahoud, Jean; Ghanem, Bernard

2017-01-01

In this paper, we present a technique that places 3D bounding boxes around objects in an RGB-D scene. Our approach makes best use of the 2D information to quickly reduce the search space in 3D, benefiting from state-of-the-art 2D object detection

4D phase contrast flow imaging for in-stent flow visualization and assessment of stent patency in peripheral vascular stents--a phantom study.

Science.gov (United States)

Bunck, Alexander C; Jüttner, Alena; Kröger, Jan Robert; Burg, Matthias C; Kugel, Harald; Niederstadt, Thomas; Tiemann, Klaus; Schnackenburg, Bernhard; Crelier, Gerard R; Heindel, Walter; Maintz, David

2012-09-01

4D phase contrast flow imaging is increasingly used to study the hemodynamics in various vascular territories and pathologies. The aim of this study was to assess the feasibility and validity of MRI based 4D phase contrast flow imaging for the evaluation of in-stent blood flow in 17 commonly used peripheral stents. 17 different peripheral stents were implanted into a MR compatible flow phantom. In-stent visibility, maximal velocity and flow visualization were assessed and estimates of in-stent patency obtained from 4D phase contrast flow data sets were compared to a conventional 3D contrast-enhanced magnetic resonance angiography (CE-MRA) as well as 2D PC flow measurements. In all but 3 of the tested stents time-resolved 3D particle traces could be visualized inside the stent lumen. Quality of 4D flow visualization and CE-MRA images depended on stent type and stent orientation relative to the magnetic field. Compared to the visible lumen area determined by 3D CE-MRA, estimates of lumen patency derived from 4D flow measurements were significantly higher and less dependent on stent type. A higher number of stents could be assessed for in-stent patency by 4D phase contrast flow imaging (n=14) than by 2D phase contrast flow imaging (n=10). 4D phase contrast flow imaging in peripheral vascular stents is feasible and appears advantageous over conventional 3D contrast-enhanced MR angiography and 2D phase contrast flow imaging. It allows for in-stent flow visualization and flow quantification with varying quality depending on stent type. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Precipitation Processes developed during ARM (1997), TOGA COARE(1992), GATE(1 974), SCSMEX(1998) and KWAJEX(1999): Consistent 2D and 3D Cloud Resolving Model Simulations

Science.gov (United States)

Tao, W.-K.; Shie, C.-H.; Simpson, J.; Starr, D.; Johnson, D.; Sud, Y.

2003-01-01

Real clouds and clouds systems are inherently three dimensional (3D). Because of the limitations in computer resources, however, most cloud-resolving models (CRMs) today are still two-dimensional (2D). A few 3D CRMs have been used to study the response of clouds to large-scale forcing. In these 3D simulations, the model domain was small, and the integration time was 6 hours. Only recently have 3D experiments been performed for multi-day periods for tropical cloud system with large horizontal domains at the National Center for Atmospheric Research. The results indicate that surface precipitation and latent heating profiles are very similar between the 2D and 3D simulations of these same cases. The reason for the strong similarity between the 2D and 3D CRM simulations is that the observed large-scale advective tendencies of potential temperature, water vapor mixing ratio, and horizontal momentum were used as the main forcing in both the 2D and 3D models. Interestingly, the 2D and 3D versions of the CRM used in CSU and U.K. Met Office showed significant differences in the rainfall and cloud statistics for three ARM cases. The major objectives of this project are to calculate and axamine: (1)the surface energy and water budgets, (2) the precipitation processes in the convective and stratiform regions, (3) the cloud upward and downward mass fluxes in the convective and stratiform regions; (4) cloud characteristics such as size, updraft intensity and lifetime, and (5) the entrainment and detrainment rates associated with clouds and cloud systems that developed in TOGA COARE, GATE, SCSMEX, ARM and KWAJEX. Of special note is that the analyzed (model generated) data sets are all produced by the same current version of the GCE model, i.e. consistent model physics and configurations. Trajectory analyse and inert tracer calculation will be conducted to identify the differences and similarities in the organization of convection between simulated 2D and 3D cloud systems.

A novel approach for a 2D/3D image registration routine for medical tool navigation in minimally invasive vascular interventions

Energy Technology Data Exchange (ETDEWEB)

Schwerter, Michael [Forschungszentrum Juelich (Germany). Inst. of Neuroscience and Medicine (INM-4) - Medical Imaging Physics; Lietzmann, Florian; Schad, Lothar R. [Heidelberg Univ., Medical Faculty Mannheim (Germany). Computer Assisted Clinical Medicine

2016-11-01

Minimally invasive interventions are frequently aided by 2D projective image guidance. To facilitate the navigation of medical tools within the patient, information from preoperative 3D images can supplement interventional data. This work describes a novel approach to perform a 3D CT data registration to a single interventional native fluoroscopic frame. The goal of this procedure is to recover and visualize a current 2D interventional tool position in its corresponding 3D dataset. A dedicated routine was developed and tested on a phantom. The 3D position of a guidewire inserted into the phantom could successfully be reconstructed for varying 2D image acquisition geometries. The scope of the routine includes projecting the CT data into the plane of the fluoroscopy. A subsequent registration of the real and virtual projections is performed with an accuracy within the range of 1.16 ± 0.17 mm for fixed landmarks. The interventional tool is extracted from the fluoroscopy and matched to the corresponding part of the projected and transformed arterial vasculature. A root mean square error of up to 0.56 mm for matched point pairs is reached. The desired 3D view is provided by backprojecting the matched guidewire through the CT array. Due to its potential to reduce patient dose and treatment times, the proposed routine has the capability of reducing patient stress at lower overall treatment costs.

Image analysis and 2D/3D modeling of the MOX fuel microstructure

International Nuclear Information System (INIS)

Oudinet, Ghislain

2003-01-01

The microstructure of the MOX fuel, made with UO_2 and PuO_2, determines his 'in pile' behavior. The french companies CEA and COGEMA are highly interested in its description by image analysis, which is the object of the present work. The segmentation algorithms described here use pictures issued from a microprobe and a SEM, to analyse the plutonium and porosity distribution in the fuel pellets. They are innovating, automated and robust enough to be used with a small data set. They have been successfully tested on different fuels, before and after irradiation. Three-dimensional informations have been computed with a genetic algorithm. The obtained 3D object size distributions allowed the modeling of many different industrial and research fuels. 3D reconstruction is accurate and stable, and provides a basis for different studies among which the study of the MOX fuel 'in pile' behavior. (author)

Non-destructive assay employing 2D and 3D digital radiographic imaging acquired with thermal neutrons and reactor-produced radioisotopes

International Nuclear Information System (INIS)

Silvani, Maria Ines; Almeida, Gevaldo Lisboa de; Lopes, Ricardo T.

2011-01-01

The inner structure of some objects can only be visualized by using suitable techniques, when safety reasons or expensive costs preclude the application of invasive procedures. The kind of agent rendering an object partially transparent, unveiling thus its features, depends upon the object size and composition. As a rough rule of thumb, light materials are transparent to gamma and X-rays while the heavy ones are transparent to neutrons. When, after traversing an object, they hit a proper 2-D detector, a radiograph is produced representing a convoluted cross section, called projection, of that object. Taking a large number of such projections for different object attitudes, it is possible to obtain a 3-D tomography of the object as a map of attenuation coefficients. This procedure however, besides a time-consuming task, requires specially tailored equipment and software, not always available or affordable. Yet, in some circumstances it is feasible to replace the 3-D tomography by a stereoscopy, allowing one to visualize the spatial configuration of the object under analysis. In this work, 2-D and 3-D radiographic images have been acquired using thermal neutrons and reactor-produced radioisotopes and proper imaging plates as detectors. The stereographic vision has been achieved by taking two radiographs of the same object at different angles, from the detector point of view. After a treatment to render them red-white and green-white they were properly merged to yield a single image capable to be watched with red-green glasses. All the image treatment and rendering has been performed with the software ImageJ. (author)

Note: Time-gated 3D single quantum dot tracking with simultaneous spinning disk imaging

International Nuclear Information System (INIS)

DeVore, M. S.; Stich, D. G.; Keller, A. M.; Phipps, M. E.; Hollingsworth, J. A.; Goodwin, P. M.; Werner, J. H.; Cleyrat, C.; Lidke, D. S.; Wilson, B. S.

2015-01-01

We describe recent upgrades to a 3D tracking microscope to include simultaneous Nipkow spinning disk imaging and time-gated single-particle tracking (SPT). Simultaneous 3D molecular tracking and spinning disk imaging enable the visualization of cellular structures and proteins around a given fluorescently labeled target molecule. The addition of photon time-gating to the SPT hardware improves signal to noise by discriminating against Raman scattering and short-lived fluorescence. In contrast to camera-based SPT, single-photon arrival times are recorded, enabling time-resolved spectroscopy (e.g., measurement of fluorescence lifetimes and photon correlations) to be performed during single molecule/particle tracking experiments

Note: Time-gated 3D single quantum dot tracking with simultaneous spinning disk imaging

Energy Technology Data Exchange (ETDEWEB)

DeVore, M. S.; Stich, D. G.; Keller, A. M.; Phipps, M. E.; Hollingsworth, J. A.; Goodwin, P. M.; Werner, J. H., E-mail: jwerner@lanl.gov [Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Mail Stop G755, Los Alamos, New Mexico 87545 (United States); Cleyrat, C.; Lidke, D. S.; Wilson, B. S. [Department of Pathology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico 87131 (United States)

2015-12-15

We describe recent upgrades to a 3D tracking microscope to include simultaneous Nipkow spinning disk imaging and time-gated single-particle tracking (SPT). Simultaneous 3D molecular tracking and spinning disk imaging enable the visualization of cellular structures and proteins around a given fluorescently labeled target molecule. The addition of photon time-gating to the SPT hardware improves signal to noise by discriminating against Raman scattering and short-lived fluorescence. In contrast to camera-based SPT, single-photon arrival times are recorded, enabling time-resolved spectroscopy (e.g., measurement of fluorescence lifetimes and photon correlations) to be performed during single molecule/particle tracking experiments.

Least-square NUFFT methods applied to 2-D and 3-D radially encoded MR image reconstruction.

Science.gov (United States)

Song, Jiayu; Liu, Yanhui; Gewalt, Sally L; Cofer, Gary; Johnson, G Allan; Liu, Qing Huo

2009-04-01

Radially encoded MRI has gained increasing attention due to its motion insensitivity and reduced artifacts. However, because its samples are collected nonuniformly in the k-space, multidimensional (especially 3-D) radially sampled MRI image reconstruction is challenging. The objective of this paper is to develop a reconstruction technique in high dimensions with on-the-fly kernel calculation. It implements general multidimensional nonuniform fast Fourier transform (NUFFT) algorithms and incorporates them into a k-space image reconstruction framework. The method is then applied to reconstruct from the radially encoded k-space data, although the method is applicable to any non-Cartesian patterns. Performance comparisons are made against the conventional Kaiser-Bessel (KB) gridding method for 2-D and 3-D radially encoded computer-simulated phantoms and physically scanned phantoms. The results show that the NUFFT reconstruction method has better accuracy-efficiency tradeoff than the KB gridding method when the kernel weights are calculated on the fly. It is found that for a particular conventional kernel function, using its corresponding deapodization function as a scaling factor in the NUFFT framework has the potential to improve accuracy. In particular, when a cosine scaling factor is used, the NUFFT method is faster than KB gridding method since a closed-form solution is available and is less computationally expensive than the KB kernel (KB griding requires computation of Bessel functions). The NUFFT method has been successfully applied to 2-D and 3-D in vivo studies on small animals.

3-D image reconstruction in radiology

International Nuclear Information System (INIS)

Grangeat, P.

1999-01-01

In this course, we present highlights on fully 3-D image reconstruction algorithms used in 3-D X-ray Computed Tomography (3-D-CT) and 3-D Rotational Radiography (3-D-RR). We first consider the case of spiral CT with a one-row detector. Starting from the 2-D fan-beam inversion formula for a circular trajectory, we introduce spiral CT 3-D image reconstruction algorithm using axial interpolation for each transverse slice. In order to improve the X-ray detection efficiency and to speed the acquisition process, the future is to use multi-row detectors associated with small angle cone-beam geometry. The generalization of the 2-D fan-beam image reconstruction algorithm to cone beam defined direct inversion formula referred as Feldkamp's algorithm for a circular trajectory and Wang's algorithm for a spiral trajectory. However, large area detectors does exist such as Radiological Image Intensifiers or in a near future solid state detectors. To get a larger zoom effect, it defines a cone-beam geometry associated with a large aperture angle. For this case, we introduce indirect image reconstruction algorithm by plane re-binning in the Radon domain. We will present some results from a prototype MORPHOMETER device using the RADON reconstruction software. Lastly, we consider the special case of 3-D Rotational Digital Subtraction Angiography with a restricted number of views. We introduce constraint optimization algorithm using quadratic, entropic or half-quadratic constraints. Generalized ART (Algebraic Reconstruction Technique) iterative reconstruction algorithm can be derived from the Bregman algorithm. We present reconstructed vascular trees from a prototype MORPHOMETER device. (author)

Multivariate cluster analysis of dynamic iodine-123 iodobenzamide SPET dopamine D2receptor images in schizophrenia

International Nuclear Information System (INIS)

Acton, P.D.; Pilowsky, L.S.; Costa, D.C.; Ell, P.J.

1997-01-01

This paper describes the application of a multivariate statistical technique to investigate striatal dopamine D 2 receptor concentrations measured by iodine-123 iodobenzamide ( 123 I-IBZM) single-photon emission tomography (SPET). This technique enables the automatic segmentation of dynamic nuclear medicine images based on the underlying time-activity curves present in the data. Once the time-activity curves have been extracted, each pixel can be mapped back on to the underlying distribution, considerably reducing image noise. Cluster analysis has been verified using computer simulations and phantom studies. The technique has been applied to SPET images of dopamine D 2 receptors in a total of 20 healthy and 20 schizophrenic volunteers (22 male, 18 female), using the ligand 123 I-IBZM. Following automatic image segmentation, the concentration of striatal dopamine D 2 receptors shows a significant left-sided asymmetry in male schizophrenics compared with male controls. The mean left-minus-right laterality index for controls is -1.52 (95% CI -3.72-0.66) and for patients 4.04 (95% CI 1.07-7.01). Analysis of variance shows a case-by-sex-by-side interaction, with F=10.01, P=0.005. We can now demonstrate that the previously observed male sex-specific D 2 receptor asymmetry in schizophrenia, which had failed to attain statistical significance, is valid. Cluster analysis of dynamic nuclear medicine studies provides a powerful tool for automatic segmentation and noise reduction of the images, removing much of the subjectivity inherent in region-of-interest analysis. The observed striatal D 2 asymmetry could reflect long hypothesized disruptions in dopamine-rich cortico-striatal-limbic circuits in schizophrenic males. (orig.). With 4 figs., 2 tabs

Validity of computational hemodynamics in human arteries based on 3D time-of-flight MR angiography and 2D electrocardiogram gated phase contrast images

Science.gov (United States)

Yu, Huidan (Whitney); Chen, Xi; Chen, Rou; Wang, Zhiqiang; Lin, Chen; Kralik, Stephen; Zhao, Ye

2015-11-01

In this work, we demonstrate the validity of 4-D patient-specific computational hemodynamics (PSCH) based on 3-D time-of-flight (TOF) MR angiography (MRA) and 2-D electrocardiogram (ECG) gated phase contrast (PC) images. The mesoscale lattice Boltzmann method (LBM) is employed to segment morphological arterial geometry from TOF MRA, to extract velocity profiles from ECG PC images, and to simulate fluid dynamics on a unified GPU accelerated computational platform. Two healthy volunteers are recruited to participate in the study. For each volunteer, a 3-D high resolution TOF MRA image and 10 2-D ECG gated PC images are acquired to provide the morphological geometry and the time-varying flow velocity profiles for necessary inputs of the PSCH. Validation results will be presented through comparisons of LBM vs. 4D Flow Software for flow rates and LBM simulation vs. MRA measurement for blood flow velocity maps. Indiana University Health (IUH) Values Fund.

MT2D Inversion to Image the Gorda Plate Subduction Zone

Science.gov (United States)

Lubis, Y. K.; Niasari, S. W.; Hartantyo, E.

2018-04-01

The magnetotelluric method is applicable for studying complicated geological structures because the subsurface electrical properties are strongly influenced by the electric and magnetic fields. This research located in the Gorda subduction zone beneath the North American continental plate. Magnetotelluric 2D inversion was used to image the variation of subsurface resistivity although the phase tensor analysis shows that the majority of dimensionality data is 3D. 19 MT sites were acquired from EarthScope/USArray Project. Wepresent the image of MT 2D inversion to exhibit conductivity distribution from the middle crust to uppermost asthenosphere at a depth of 120 kilometers. Based on the inversion, the overall data misfit value is 3.89. The Gorda plate subduction appears as a high resistive zone beneath the California. Local conductive features are found in the middle crust downward Klamath Mountain, Bonneville Lake, and below the eastern of Utah. Furthermore, mid-crustal is characterized by moderately resistive. Below the extensional Basin and Range province was related to highly resistive. The middle crust to the uppermost asthenosphere becomes moderately resistive. We conclude that the electrical parameters and the dimensionality of datain the shallow depth(about 22.319 km) beneath the North American platein accordance with surface geological features.

4D phase contrast flow imaging for in-stent flow visualization and assessment of stent patency in peripheral vascular stents – A phantom study

International Nuclear Information System (INIS)

Bunck, Alexander C.; Jüttner, Alena; Kröger, Jan Robert; Burg, Matthias C.; Kugel, Harald; Niederstadt, Thomas; Tiemann, Klaus; Schnackenburg, Bernhard; Crelier, Gerard R.

2012-01-01

Purpose: 4D phase contrast flow imaging is increasingly used to study the hemodynamics in various vascular territories and pathologies. The aim of this study was to assess the feasibility and validity of MRI based 4D phase contrast flow imaging for the evaluation of in-stent blood flow in 17 commonly used peripheral stents. Materials and methods: 17 different peripheral stents were implanted into a MR compatible flow phantom. In-stent visibility, maximal velocity and flow visualization were assessed and estimates of in-stent patency obtained from 4D phase contrast flow data sets were compared to a conventional 3D contrast-enhanced magnetic resonance angiography (CE-MRA) as well as 2D PC flow measurements. Results: In all but 3 of the tested stents time-resolved 3D particle traces could be visualized inside the stent lumen. Quality of 4D flow visualization and CE-MRA images depended on stent type and stent orientation relative to the magnetic field. Compared to the visible lumen area determined by 3D CE-MRA, estimates of lumen patency derived from 4D flow measurements were significantly higher and less dependent on stent type. A higher number of stents could be assessed for in-stent patency by 4D phase contrast flow imaging (n = 14) than by 2D phase contrast flow imaging (n = 10). Conclusions: 4D phase contrast flow imaging in peripheral vascular stents is feasible and appears advantageous over conventional 3D contrast-enhanced MR angiography and 2D phase contrast flow imaging. It allows for in-stent flow visualization and flow quantification with varying quality depending on stent type

Initial clinical experiences with dopamine D2 receptor imaging by means of 2'-iodospiperone and single-photon emission computed tomography

International Nuclear Information System (INIS)

Yonekura, Yoshiharu; Saji, Hideo; Iwasaki, Yasushi

1995-01-01

Dopamine D 2 receptor imaging was performed with 123 I labeled 2'-iodospiperone (2'-ISP) and single-photon emission computed tomography (SPECT) in 9 patients: 4 with idiopathic Parkinson's disease, 2 with parkinsonism, 1 with Wilson's disease and 2 with pituitary tumor, and the results were compared with the data for 9 normal subjects. Following an intravenous injection of 123 I-2'-ISP, early (within 30 min) and late (between 2 and 4 hr) SPECT images were obtained by means of a multi-detector SPECT scanner or a rotating gamma camera. In normal subjects, early SPECT images demonstrated uniform distribution of radioactivity in the cerebral gray matter and cerebellum reflecting regional cerebral blood flow, whereas late SPECT images showed high radioactivity only in the basal ganglia. All the patients with Parkinson's disease also demonstrated symmetrical basal ganglia uptake in the late SPECT images, but it was diminished in parkinsonism and Wilson's disease. One patient with a growth hormone-producing pituitary tumor had a positive uptake in the tumor. These preliminary clinical data demonstrated that 2'-ISP can be used for SPECT imaging of D 2 dopamine receptors and may be of clinical value for the diagnosis and planning of the treatment of neurological diseases. (author)

Groundwater exploration using 2D Resistivity Imaging in Pagoh, Johor, Malaysia

Science.gov (United States)

Kadri, Muhammad; Nawawi, M. N. M.

2010-12-01

Groundwater is a very important component of water resources in nature. Since the demand of groundwater increases with population growth, it is necessary to explore groundwater more intensively. In Malaysia only less than 2% of the present water used is developed from groundwater. In order to determine the existence of usable groundwater for irrigation and drinking purposes in Pagoh, 2D resistivity imaging technique was utilized. The 2-D resistivity imaging technique utilized the Wenner—Schlumberger electrode array configuration because this array is moderately sensitive to both horizontal and vertical structures. Three lines were surveyed for groundwater delineation purpose The length for each survey lines are 400 meters. At Pagoh, the survey site shows the existence of groundwater. It is indicated by the resistivity values about 10-100 ohm-m. The maximum depth of investigation survey is 77 meters. In general the results show that the subsurface is made up of alluvium and clay and the high resistivity values of more than 1000 ohm-m near the surface is due laterite and the end of the depth can be interpreted as mixture of weathered material or bedrock.

T2-Weighted 4D Magnetic Resonance Imaging for Application in Magnetic Resonance–Guided Radiotherapy Treatment Planning

Science.gov (United States)

Freedman, Joshua N.; Collins, David J.; Bainbridge, Hannah; Rank, Christopher M.; Nill, Simeon; Kachelrieß, Marc; Oelfke, Uwe; Leach, Martin O.; Wetscherek, Andreas

2017-01-01

Objectives The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. Materials and Methods Ten patients with primary non–small cell lung cancer were scanned at 1.5 T axially with a volumetric T2-weighted turbo spin echo sequence gated to exhalation and a volumetric T1-weighted stack-of-stars spoiled gradient echo sequence with golden angle spacing acquired in free breathing. From the latter, 20 respiratory phases were reconstructed using the recently developed 4D joint MoCo-HDTV algorithm based on the self-gating signal obtained from the k-space center. Motion vector fields describing the respiratory cycle were obtained by deformable image registration between the respiratory phases and projected onto the T2-weighted image volume. The resulting 4D-T2w volumes were verified against the 4D-T1w volumes: an edge-detection method was used to measure the diaphragm positions; the locations of anatomical landmarks delineated by a radiation oncologist were compared and normalized mutual information was calculated to evaluate volumetric image similarity. Results High-resolution 4D-T2w MRI was obtained. Respiratory motion was preserved on calculated 4D-T2w MRI, with median diaphragm positions being consistent with less than 6.6 mm (2 voxels) for all patients and less than 3.3 mm (1 voxel) for 9 of 10 patients. Geometrical positions were coherent between 4D-T1w and 4D-T2w MRI as Euclidean distances between all corresponding anatomical landmarks agreed to within 7.6 mm (Euclidean distance of 2 voxels) and were below 3.8 mm (Euclidean distance of 1 voxel) for 355 of 470 pairs of anatomical landmarks. Volumetric image similarity was commensurate between 4D-T1w and 4D-T2w MRI, as mean percentage differences in normalized mutual information (calculated over all

T2-Weighted 4D Magnetic Resonance Imaging for Application in Magnetic Resonance-Guided Radiotherapy Treatment Planning.

Science.gov (United States)

Freedman, Joshua N; Collins, David J; Bainbridge, Hannah; Rank, Christopher M; Nill, Simeon; Kachelrieß, Marc; Oelfke, Uwe; Leach, Martin O; Wetscherek, Andreas

2017-10-01

The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. Ten patients with primary non-small cell lung cancer were scanned at 1.5 T axially with a volumetric T2-weighted turbo spin echo sequence gated to exhalation and a volumetric T1-weighted stack-of-stars spoiled gradient echo sequence with golden angle spacing acquired in free breathing. From the latter, 20 respiratory phases were reconstructed using the recently developed 4D joint MoCo-HDTV algorithm based on the self-gating signal obtained from the k-space center. Motion vector fields describing the respiratory cycle were obtained by deformable image registration between the respiratory phases and projected onto the T2-weighted image volume. The resulting 4D-T2w volumes were verified against the 4D-T1w volumes: an edge-detection method was used to measure the diaphragm positions; the locations of anatomical landmarks delineated by a radiation oncologist were compared and normalized mutual information was calculated to evaluate volumetric image similarity. High-resolution 4D-T2w MRI was obtained. Respiratory motion was preserved on calculated 4D-T2w MRI, with median diaphragm positions being consistent with less than 6.6 mm (2 voxels) for all patients and less than 3.3 mm (1 voxel) for 9 of 10 patients. Geometrical positions were coherent between 4D-T1w and 4D-T2w MRI as Euclidean distances between all corresponding anatomical landmarks agreed to within 7.6 mm (Euclidean distance of 2 voxels) and were below 3.8 mm (Euclidean distance of 1 voxel) for 355 of 470 pairs of anatomical landmarks. Volumetric image similarity was commensurate between 4D-T1w and 4D-T2w MRI, as mean percentage differences in normalized mutual information (calculated over all respiratory phases and patients), between

Time-resolved imaging of purely valence-electron dynamics during a chemical reaction

DEFF Research Database (Denmark)

Hockett, Paul; Bisgaard, Christer Z.; Clarkin, Owen J.

2011-01-01

Chemical reactions are manifestations of the dynamics of molecular valence electrons and their couplings to atomic motions. Emerging methods in attosecond science can probe purely electronic dynamics in atomic and molecular systems(1-6). By contrast, time-resolved structural-dynamics methods...... such as electron(7-10) or X-ray diffraction(11) and X-ray absorption(12) yield complementary information about the atomic motions. Time-resolved methods that are directly sensitive to both valence-electron dynamics and atomic motions include photoelectron spectroscopy(13-15) and high-harmonic generation(16......,17): in both cases, this sensitivity derives from the ionization-matrix element(18,19). Here we demonstrate a time-resolved molecular-frame photoelectron-angular-distribution (TRMFPAD) method for imaging the purely valence-electron dynamics during a chemical reaction. Specifically, the TRMFPADs measured during...

Exploring 4D quantum Hall physics with a 2D topological charge pump.

Science.gov (United States)

Lohse, Michael; Schweizer, Christian; Price, Hannah M; Zilberberg, Oded; Bloch, Immanuel

2018-01-03

The discovery of topological states of matter has greatly improved our understanding of phase transitions in physical systems. Instead of being described by local order parameters, topological phases are described by global topological invariants and are therefore robust against perturbations. A prominent example is the two-dimensional (2D) integer quantum Hall effect: it is characterized by the first Chern number, which manifests in the quantized Hall response that is induced by an external electric field. Generalizing the quantum Hall effect to four-dimensional (4D) systems leads to the appearance of an additional quantized Hall response, but one that is nonlinear and described by a 4D topological invariant-the second Chern number. Here we report the observation of a bulk response with intrinsic 4D topology and demonstrate its quantization by measuring the associated second Chern number. By implementing a 2D topological charge pump using ultracold bosonic atoms in an angled optical superlattice, we realize a dynamical version of the 4D integer quantum Hall effect. Using a small cloud of atoms as a local probe, we fully characterize the nonlinear response of the system via in situ imaging and site-resolved band mapping. Our findings pave the way to experimentally probing higher-dimensional quantum Hall systems, in which additional strongly correlated topological phases, exotic collective excitations and boundary phenomena such as isolated Weyl fermions are predicted.

Exploring 4D quantum Hall physics with a 2D topological charge pump

Science.gov (United States)

Lohse, Michael; Schweizer, Christian; Price, Hannah M.; Zilberberg, Oded; Bloch, Immanuel

2018-01-01

The discovery of topological states of matter has greatly improved our understanding of phase transitions in physical systems. Instead of being described by local order parameters, topological phases are described by global topological invariants and are therefore robust against perturbations. A prominent example is the two-dimensional (2D) integer quantum Hall effect: it is characterized by the first Chern number, which manifests in the quantized Hall response that is induced by an external electric field. Generalizing the quantum Hall effect to four-dimensional (4D) systems leads to the appearance of an additional quantized Hall response, but one that is nonlinear and described by a 4D topological invariant—the second Chern number. Here we report the observation of a bulk response with intrinsic 4D topology and demonstrate its quantization by measuring the associated second Chern number. By implementing a 2D topological charge pump using ultracold bosonic atoms in an angled optical superlattice, we realize a dynamical version of the 4D integer quantum Hall effect. Using a small cloud of atoms as a local probe, we fully characterize the nonlinear response of the system via in situ imaging and site-resolved band mapping. Our findings pave the way to experimentally probing higher-dimensional quantum Hall systems, in which additional strongly correlated topological phases, exotic collective excitations and boundary phenomena such as isolated Weyl fermions are predicted.

Time-resolved measurements with intense ultrashort laser pulses: a 'molecular movie' in real time

International Nuclear Information System (INIS)

Rudenko, A; Ergler, Th; Feuerstein, B; Zrost, K; Schroeter, C D; Moshammer, R; Ullrich, J

2007-01-01

We report on the high-resolution multidimensional real-time mapping of H 2 + and D 2 + nuclear wave packets performed employing time-resolved three-dimensional Coulomb explosion imaging with intense laser pulses. Exploiting a combination of a 'reaction microscope' spectrometer and a pump-probe setup with two intense 6-7 fs laser pulses, we simultaneously visualize both vibrational and rotational motion of the molecule, and obtain a sequence of snapshots of the squared ro-vibrational wave function with time-step resolution of ∼ 0.3 fs, allowing us to reconstruct a real-time movie of the ultrafast molecular motion. We observe fast dephasing, or 'collapse' of the vibrational wave packet and its subsequent revival, as well as signatures of rotational excitation. For D 2 + we resolve also the fractional revivals resulting from the interference between the counter-propagating parts of the wave packet

4-D flow magnetic resonance imaging: blood flow quantification compared to 2-D phase-contrast magnetic resonance imaging and Doppler echocardiography

Energy Technology Data Exchange (ETDEWEB)

Gabbour, Maya [Ann and Robert H. Lurie Children' s Hospital of Chicago, Department of Medical Imaging 9, Chicago, IL (United States); Schnell, Susanne [Northwestern University Feinberg School of Medicine, Department of Radiology, Chicago, IL (United States); Jarvis, Kelly [Northwestern University, Department of Biomedical Engineering, McCormick School of Engineering, Evanston, IL (United States); Robinson, Joshua D. [Ann and Robert H. Lurie Children' s Hospital of Chicago, Department of Pediatrics, Division of Pediatric Cardiology, Chicago, IL (United States); Northwestern University Feinberg School of Medicine, Department of Pediatrics, Chicago, IL (United States); Markl, Michael [Northwestern University Feinberg School of Medicine, Department of Radiology, Chicago, IL (United States); Northwestern University, Department of Biomedical Engineering, McCormick School of Engineering, Evanston, IL (United States); Rigsby, Cynthia K. [Ann and Robert H. Lurie Children' s Hospital of Chicago, Department of Medical Imaging 9, Chicago, IL (United States); Northwestern University Feinberg School of Medicine, Department of Radiology, Chicago, IL (United States)

2015-06-15

Doppler echocardiography (echo) is the reference standard for blood flow velocity analysis, and two-dimensional (2-D) phase-contrast magnetic resonance imaging (MRI) is considered the reference standard for quantitative blood flow assessment. However, both clinical standard-of-care techniques are limited by 2-D acquisitions and single-direction velocity encoding and may make them inadequate to assess the complex three-dimensional hemodynamics seen in congenital heart disease. Four-dimensional flow MRI (4-D flow) enables qualitative and quantitative analysis of complex blood flow in the heart and great arteries. The objectives of this study are to compare 4-D flow with 2-D phase-contrast MRI for quantification of aortic and pulmonary flow and to evaluate the advantage of 4-D flow-based volumetric flow analysis compared to 2-D phase-contrast MRI and echo for peak velocity assessment in children and young adults. Two-dimensional phase-contrast MRI of the aortic root, main pulmonary artery (MPA), and right and left pulmonary arteries (RPA, LPA) and 4-D flow with volumetric coverage of the aorta and pulmonary arteries were performed in 50 patients (mean age: 13.1 ± 6.4 years). Four-dimensional flow analyses included calculation of net flow and regurgitant fraction with 4-D flow analysis planes similarly positioned to 2-D planes. In addition, 4-D flow volumetric assessment of aortic root/ascending aorta and MPA peak velocities was performed and compared to 2-D phase-contrast MRI and echo. Excellent correlation and agreement were found between 2-D phase-contrast MRI and 4-D flow for net flow (r = 0.97, P < 0.001) and excellent correlation with good agreement was found for regurgitant fraction (r = 0.88, P < 0.001) in all vessels. Two-dimensional phase-contrast MRI significantly underestimated aortic (P = 0.032) and MPA (P < 0.001) peak velocities compared to echo, while volumetric 4-D flow analysis resulted in higher (aortic: P = 0.001) or similar (MPA: P = 0.98) peak

Parallax barrier engineering for image quality improvement in an autostereoscopic 3D display.

Science.gov (United States)

Kim, Sung-Kyu; Yoon, Ki-Hyuk; Yoon, Seon Kyu; Ju, Heongkyu

2015-05-18

We present a image quality improvement in a parallax barrier (PB)-based multiview autostereoscopic 3D display system under a real-time tracking of positions of a viewer's eyes. The system presented exploits a parallax barrier engineered to offer significantly improved quality of three-dimensional images for a moving viewer without an eyewear under the dynamic eye tracking. The improved image quality includes enhanced uniformity of image brightness, reduced point crosstalk, and no pseudoscopic effects. We control the relative ratio between two parameters i.e., a pixel size and the aperture of a parallax barrier slit to improve uniformity of image brightness at a viewing zone. The eye tracking that monitors positions of a viewer's eyes enables pixel data control software to turn on only pixels for view images near the viewer's eyes (the other pixels turned off), thus reducing point crosstalk. The eye tracking combined software provides right images for the respective eyes, therefore producing no pseudoscopic effects at its zone boundaries. The viewing zone can be spanned over area larger than the central viewing zone offered by a conventional PB-based multiview autostereoscopic 3D display (no eye tracking). Our 3D display system also provides multiviews for motion parallax under eye tracking. More importantly, we demonstrate substantial reduction of point crosstalk of images at the viewing zone, its level being comparable to that of a commercialized eyewear-assisted 3D display system. The multiview autostereoscopic 3D display presented can greatly resolve the point crosstalk problem, which is one of the critical factors that make it difficult for previous technologies for a multiview autostereoscopic 3D display to replace an eyewear-assisted counterpart.

Effects of Precipitation on Ocean Mixed-Layer Temperature and Salinity as Simulated in a 2-D Coupled Ocean-Cloud Resolving Atmosphere Model

Science.gov (United States)

Li, Xiaofan; Sui, C.-H.; Lau, K-M.; Adamec, D.

1999-01-01

A two-dimensional coupled ocean-cloud resolving atmosphere model is used to investigate possible roles of convective scale ocean disturbances induced by atmospheric precipitation on ocean mixed-layer heat and salt budgets. The model couples a cloud resolving model with an embedded mixed layer-ocean circulation model. Five experiment are performed under imposed large-scale atmospheric forcing in terms of vertical velocity derived from the TOGA COARE observations during a selected seven-day period. The dominant variability of mixed-layer temperature and salinity are simulated by the coupled model with imposed large-scale forcing. The mixed-layer temperatures in the coupled experiments with 1-D and 2-D ocean models show similar variations when salinity effects are not included. When salinity effects are included, however, differences in the domain-mean mixed-layer salinity and temperature between coupled experiments with 1-D and 2-D ocean models could be as large as 0.3 PSU and 0.4 C respectively. Without fresh water effects, the nocturnal heat loss over ocean surface causes deep mixed layers and weak cooling rates so that the nocturnal mixed-layer temperatures tend to be horizontally-uniform. The fresh water flux, however, causes shallow mixed layers over convective areas while the nocturnal heat loss causes deep mixed layer over convection-free areas so that the mixed-layer temperatures have large horizontal fluctuations. Furthermore, fresh water flux exhibits larger spatial fluctuations than surface heat flux because heavy rainfall occurs over convective areas embedded in broad non-convective or clear areas, whereas diurnal signals over whole model areas yield high spatial correlation of surface heat flux. As a result, mixed-layer salinities contribute more to the density differences than do mixed-layer temperatures.

Photon-Counting Arrays for Time-Resolved Imaging

Directory of Open Access Journals (Sweden)

I. Michel Antolovic

2016-06-01

Full Text Available The paper presents a camera comprising 512 × 128 pixels capable of single-photon detection and gating with a maximum frame rate of 156 kfps. The photon capture is performed through a gated single-photon avalanche diode that generates a digital pulse upon photon detection and through a digital one-bit counter. Gray levels are obtained through multiple counting and accumulation, while time-resolved imaging is achieved through a 4-ns gating window controlled with subnanosecond accuracy by a field-programmable gate array. The sensor, which is equipped with microlenses to enhance its effective fill factor, was electro-optically characterized in terms of sensitivity and uniformity. Several examples of capture of fast events are shown to demonstrate the suitability of the approach.

Ultralow-dose CT of the craniofacial bone for navigated surgery using adaptive statistical iterative reconstruction and model-based iterative reconstruction: 2D and 3D image quality.

Science.gov (United States)

Widmann, Gerlig; Schullian, Peter; Gassner, Eva-Maria; Hoermann, Romed; Bale, Reto; Puelacher, Wolfgang

2015-03-01

OBJECTIVE. The purpose of this article is to evaluate 2D and 3D image quality of high-resolution ultralow-dose CT images of the craniofacial bone for navigated surgery using adaptive statistical iterative reconstruction (ASIR) and model-based iterative reconstruction (MBIR) in comparison with standard filtered backprojection (FBP). MATERIALS AND METHODS. A formalin-fixed human cadaver head was scanned using a clinical reference protocol at a CT dose index volume of 30.48 mGy and a series of five ultralow-dose protocols at 3.48, 2.19, 0.82, 0.44, and 0.22 mGy using FBP and ASIR at 50% (ASIR-50), ASIR at 100% (ASIR-100), and MBIR. Blinded 2D axial and 3D volume-rendered images were compared with each other by three readers using top-down scoring. Scores were analyzed per protocol or dose and reconstruction. All images were compared with the FBP reference at 30.48 mGy. A nonparametric Mann-Whitney U test was used. Statistical significance was set at p ASIR-100 at 3.48 mGy, ASIR-100 at 2.19 mGy, and MBIR at 0.82 mGy. MBIR at 2.19 and 3.48 mGy scored statistically significantly better than the FBP reference (p = 0.032 and 0.001, respectively). For 3D images, the FBP reference at 30.48 mGy did not statistically significantly differ from all reconstructions at 3.48 mGy; FBP and ASIR-100 at 2.19 mGy; FBP, ASIR-100, and MBIR at 0.82 mGy; MBIR at 0.44 mGy; and MBIR at 0.22 mGy. CONCLUSION. MBIR (2D and 3D) and ASIR-100 (2D) may significantly improve subjective image quality of ultralow-dose images and may allow more than 90% dose reductions.