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Sample records for resistance index ri

  1. Resistive index(RI) of the intratesticular artery in orchitis: comparison with normal testis

    International Nuclear Information System (INIS)

    Yang, Dal Mo; Kim, Hyung Sik; Lee, Young Seok; Yoon, Myung Hwan; Lee, Jong Bouk; Yun, Jung Chul

    1994-01-01

    Color doppler ultrasound is ideally suited for diagnosing acute scrotal disease as it provides simultaneous display of tissue morphology and blood flow. This study was performed in order to evaluate the utility of resistive index(RI) of intratesticular arteries in orchitis. We retrospectively analyzed 18 testes of 15 patients confirmed by means of appropriate response to antibiotic treatment and 20 testes of 10 asymptomatic volunteers.The resistive indexes ranged from 0.25 to 0.60 (mean, 0.48) in orchitis, and from 0.50 to 0.71 (mean, 0.62) in volunteers. Thus, the resistive index in orchitis is significantly lower than that of the volunteers (p<0.05).With a cut-off point of resistive index at 0.6, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 94%, 90%, 89%, 95% and 92%m respectively. We conclude that decreased resistive index is a helpful finding in the diagnosis of orchitis, and we suggest the resistive index of 0.6 as a cut-off point

  2. Doppler sonographic renal resistance index and resistance index ratio in children and adolescents with unilateral hydronephrosis

    Energy Technology Data Exchange (ETDEWEB)

    Brkljacic, Boris [Department of Radiology, University Hospital ' ' Dubrava' ' , Av. G. Suska 6, 10000 Zagreb (Croatia); Kuzmic, Andrea Cvitkovic; Dmitrovic, Romana [Department of Pediatric Nephrology, Children' s Hospital, Klaiceva 16, 10000 Zagreb (Croatia); Rados, Marko [Department of Radiology, University Hospital Center, Kispaticeva 12, 10000 Zagreb (Croatia); Vidjak, Vinko [Department of Radiology, University Hospital ' ' Merkur' ' , Zajceva 19, 10000 Zagreb (Croatia)

    2002-11-01

    The aim of this study was to evaluate Doppler renal resistance index (RI) and RI ratio (RIR) in differentiating between obstructive and nonobstructive hydronephrosis in children and adolescents. The RI and RIR were measured in 32 healthy examinees (control group) and 29 patients with unilateral hydronephrosis. Ten patients had acute obstruction caused by a ureteric stone. Seven had obstructive hydronephrosis due to uretero-pelvic junction (UPJ) obstruction. Twelve patients had nonobstructive hydronephrosis. In controls the mean RI{+-}S.D. was 0.615{+-}0.04, and RIR 1.045{+-}0.033. In children with acute obstruction RI was 0.692{+-}0.035 and RIR 1.148{+-}0.037. In UPJ obstruction RI was 0.631{+-}0.054 and RIR 1.059{+-}0.047. In nonobstructive dilatation RI was 0.61{+-}0.038 and RIR 1.043{+-}0.042. The RI and RIR differences were statistically significant between controls and patients with acute colic (p<0.01), and between patients with acute obstruction and with nonobstructive hydronephrosis (p<0.01). In detecting acute obstruction RI{>=}0.70 was found to have a 70% sensitivity and a 92% specificity. The RIR{>=}1.10 was found optimal to distinguish obstructive from nonobstructive dilatation (sensitivity 90%, specificity 83%). Both RI and RIR are significantly elevated in patients with acute obstruction. Renal Doppler seems to be useful in children and adolescents for the detection of acute renal obstruction, although it cannot differentiate chronic obstruction due to the UPJ obstruction and nonobstructive renal collecting system dilatation. (orig.)

  3. Doppler sonographic renal resistance index and resistance index ratio in children and adolescents with unilateral hydronephrosis

    International Nuclear Information System (INIS)

    Brkljacic, Boris; Kuzmic, Andrea Cvitkovic; Dmitrovic, Romana; Rados, Marko; Vidjak, Vinko

    2002-01-01

    The aim of this study was to evaluate Doppler renal resistance index (RI) and RI ratio (RIR) in differentiating between obstructive and nonobstructive hydronephrosis in children and adolescents. The RI and RIR were measured in 32 healthy examinees (control group) and 29 patients with unilateral hydronephrosis. Ten patients had acute obstruction caused by a ureteric stone. Seven had obstructive hydronephrosis due to uretero-pelvic junction (UPJ) obstruction. Twelve patients had nonobstructive hydronephrosis. In controls the mean RI±S.D. was 0.615±0.04, and RIR 1.045±0.033. In children with acute obstruction RI was 0.692±0.035 and RIR 1.148±0.037. In UPJ obstruction RI was 0.631±0.054 and RIR 1.059±0.047. In nonobstructive dilatation RI was 0.61±0.038 and RIR 1.043±0.042. The RI and RIR differences were statistically significant between controls and patients with acute colic (p<0.01), and between patients with acute obstruction and with nonobstructive hydronephrosis (p<0.01). In detecting acute obstruction RI≥0.70 was found to have a 70% sensitivity and a 92% specificity. The RIR≥1.10 was found optimal to distinguish obstructive from nonobstructive dilatation (sensitivity 90%, specificity 83%). Both RI and RIR are significantly elevated in patients with acute obstruction. Renal Doppler seems to be useful in children and adolescents for the detection of acute renal obstruction, although it cannot differentiate chronic obstruction due to the UPJ obstruction and nonobstructive renal collecting system dilatation. (orig.)

  4. DETERMINATION OF ATTENUATION INDEX CURVE "Ri(f" FOR HOMOGENEOUS DOUBLE LOCKING ELEMENTS

    Directory of Open Access Journals (Sweden)

    BUZATU G. C.

    2016-12-01

    Full Text Available The paper is structured in three parts. In the first part of the paper, are presented some theoretical notions regarding the sound, noise, the sound insulations materials. Also in the first part of the paper are presented some characteristic regarding the insulation materials and there effects. In the second part it is described an calculation example for a homogeneous wall with double structure in order to determine the attenuation index curve "Ri(f". The example calculation contains 10 steps that must be followed and the final results are presented in table 7 and figure 3. The last part of the paper is represented by conclusions, where the authors tried to explain the importance of the curve "Ri(f" for reducing the noise in the buildings.

  5. The pulsatility index and the resistive index in renal arteries. Associations with long-term progression in chronic renal failure

    DEFF Research Database (Denmark)

    Petersen, L J; Petersen, J R; Talleruphuus, U

    1997-01-01

    The pulsatility index (PI) and the resistive index (RI) are used as pulsed-wave Doppler measurements of downstream renal artery resistance. PI and RI have been found to correlate with renal vascular resistance, filtration fraction and effective renal plasma flow in chronic renal failure. The aim...... of the present study was to evaluate the potential relationship between these indices and the rate of decline in renal function, as reflected by changes in different parameters of renal function in patients with chronic renal failure....

  6. Resistive index for kidney evaluation in normal and diseased cats.

    Science.gov (United States)

    Tipisca, Vlad; Murino, Carla; Cortese, Laura; Mennonna, Giuseppina; Auletta, Luigi; Vulpe, Vasile; Meomartino, Leonardo

    2016-06-01

    The objectives were to determine the resistive index (RI) in normal cats and in cats with various renal diseases, and to evaluate the effect of age on RI. The subjects were cats that had ultrasonography (US) of the urinary tract and RI measurement at our centre between January 2003 and April 2014. Based on clinical evaluation, biochemical and haematological tests, urinalysis and US, the cats were classified as healthy or diseased. RI measurements were made from the interlobar or arcuate arteries. Data were analysed for differences between the right and the left kidney, the two sexes, different age groups in healthy cats, and between healthy and diseased cats. A total of 116 cats (68 males, 48 females) were included: 24 healthy and 92 diseased. In the healthy cats, RI (mean ± SD) differed significantly (P = 0.02) between the right kidney (0.54 ± 0.07) and the left kidney (0.59 ± 0.08). For the left kidney, RI was significantly higher in cats with chronic kidney disease (0.73 ± 0.12) and acute kidney injury (0.72 ± 0.08) (P = 0.0008). For the right kidney, RI was significantly higher in cats with chronic kidney disease (0.72 ± 0.11), acute kidney injury (0.74 ± 0.08), polycystic kidney disease (0.77 ± 0.11) and renal tumour (0.74 ± 0.001) (P cats, useful in the differential diagnosis of diffuse renal diseases. While it does not change with the age of the cat, ultrasonographers should be aware that RI may differ between the two kidneys. © ISFM and AAFP 2015.

  7. Resistive index in breast tumors; usefulness on differentiation between benign and malignant lesions

    International Nuclear Information System (INIS)

    An, Eun Joo; Choi, Hye Young; Baek, Seung Yon; Kim, Ah Young; Choe, Du Hwan

    1996-01-01

    We assessed the usefulness of resistive index(RI) on spectral analysis of doppler sonography for differential diagnosis of benign and malignant breast lesions. We retrospectively reviewed 29 benign and 22 malignant lesions of breast, which were examined preoperatively with color and duplex Doppler and were confirmed by histopathologically after operation. We analyzed the average and distribution of RI in benign and malignant lesions. Although, there was no difference in the average values of RI in benign and malignant breast lesions, the distribution of RI was below 0.7 in eighteen cases (62%) of benign lesions, and above 0.7 in eighteen cases (82%) of malignant lesions. Thus, RI is valuable for differentiation between benign and malignant lesions of breast. Measurement of RI in breast disease using color and duplex Doppler study is useful modality adjunct to the conventional ultrasonographic differentiation of benign and malignant lesions

  8. The pulsatility index and the resistive index in renal arteries in patients with hypertension and chronic renal failure

    DEFF Research Database (Denmark)

    Petersen, L J; Petersen, J R; Ladefoged, S D

    1995-01-01

    The pulsatility index (PI) and the resistive index (RI) are used as pulsed-wave Doppler measurement of downstream renal artery resistance. Little information is available on their value in chronic renal failure and their correlation to parameters of renal function and haemodynamics. The aim...... was to compare PI and RI of renal arteries in healthy volunteers and in patients with hypertension and chronic renal failure, and furthermore to study the correlation of these indices to measurements of renal haemodynamics and function by standard methods in patients with renal failure and hypertension....

  9. Evaluation of the renal resistive index and pulsatility index in patients with pleural effusion by duplex Doppler ultrasonography.

    Science.gov (United States)

    Değirmenci, Nevbahar Akcar; Metintaş, Muzaffer; Atlanoglu, Sahinde; Yıldırım, Huseyin

    2013-01-01

    The aim of the study was to evaluate the renal resistive index (RI) and pulsatility index (PI) in patients with pleural effusion (PE). We studied the mean renal RI and PI in 50 patients with PE and 30 healthy volunteers by Doppler sonography. We grouped effusion as unilateral and bilateral. Statistical analysis was done by independent t test and correlation coefficient analysis. The mean RI/PI in healthy volunteers and in PE patients was 0.58/0.93 and 0.72/1.35, respectively. We observed a significantly higher RI and PI in patients when compared with healthy volunteers (all p effusion (0.74 or 1.55, respectively) (p > 0.05). Pleural effusion might result in increased renal impedance as seen in cirrhosis, which is a rather complicated pathophysiological process, without causing any morphological changes in kidneys.

  10. The value of intrarenal resistive index in autosomal dominant polycystic kidney disease

    International Nuclear Information System (INIS)

    Lee, Young Rae; Lee, Kyu Beck; Park, Hae Won

    1998-01-01

    The purpose of this study was to determine the value of the intrarenal resistive index(RI), measured by Doppler sonography, in order to assess intrarenal vascular resistance in autosomal dominant polycystic kidney disease (ADPKD) patients. In 26 patients with ADPKD, RI was measured by Doppler sonography and correlated with the presence of hypertension, renal function (creatinine clearance) and anatomical renal severity index (RSI), thus indicating renal morphologic abnormalities during Bmode sonography. RI was significantly higher in 18 hypertensive ADPKD patients (0.64±0.65) (Mean±1SD;range:0.52-0.74) than in eight normotensive patients (0.59± 0.50) (0.48-0.64) (p<0.05). Statistically significant inverse correlation was found between RI values and creatinine clearance (r=3D-0.45, p<0.05), and statistically significant correlation was found between RI values and RSI, indicating the degree of renal parenchymal involvement. RI correlates with the development of hypertension, renal function and renal morphologic abnormality scoring by RSI during B-mode Doppler sonography, and measured in this way may thus be used to assess renal vascular resistance in ADPKD patients.=20

  11. The value of intrarenal resistive index in patients with liver cirrhosis

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Young Rae [Kangbuk Samsung Hospital, Seoul (Korea, Republic of)

    1997-08-01

    To determine whether the value of the intrarenal resistive index(RI) can be used to identify early kidney vasoconstriciton in patients with nonazotemic liver cirrhosis The intrarneal resistive index (RI), kidney and liver function and plasma renin activity were measured in 12 healthy control subjects, 13 cirrhotic patients without ascites and 29 cirrhotic patients with ascites. To evaluate the development of hepatorenal syndrome, patients were followed up for six months. RI was significantly higher in patients with cirrhosis (0.68{+-}0.06) than in healthy subjects (0.59{+-}0.04). In 42 cirrhotic patients, it was significantly higher in those with ascites (0.69{+-}0.05) than in those without ascites (0.64{+-}0.05) and correlated with creatinine clearance. Plasma renin activity was significantly highter in cirrhotic patients with ascites than in those without ascites and healthy subjects (p<0.05). During the six-month follow-up period, kidney dysfunction developed in 16%(7/42) of cirrhotic patiens, and in 37%(6/16) of those with an elevated RI. In contrast, only 4%(1/26) of patients with a normal RI has kidney dysfunction. The measurement of intrarenal resitive index(RI) using duplex Doppler ultrasound is a simple, noninvasive method of detecting even subtle derangements of renal hemodynamics in liver cirrhosis patients;the procedure can be used to identify those who are at higher risk of overt renal failure and to help decide whether a therapeutic approach involving paracentesis, diuretics, or nephrotoxic agents is most appropriate.

  12. Resistive index on doppler ultrasound after renal transplantation as renal function predictor

    International Nuclear Information System (INIS)

    Khan, S.; Baloch, S.

    2015-01-01

    To determine the correlation between doppler resistive index and serum creatinine levels in renal transplant recipients. Study Design: Cross sectional study. Place and Duration of Study: Department of Radiology, Military Hospital Rawalpindi from Oct 2009 to Oct 2010. Patients and Method: A total of 82 outdoor and admitted patients of both genders, within age group of 18-60 years, were included in the study. These patients were referred from Nephrology department Military Hospital, Rwp and Armed Forces Institute of Urology after renal transplant. Written informed consent was taken along with history of any co-morbid disease like dabetes or hypertension and for post transplant duration. Gray scale ultrasound was performed first, followed by doppler ultrasound of transplanted kidney and resistive index was calculated. The presence of any post transplant complications were also recorded. The values of resistive index were then correlated with the serum creatinine levels. Results: Doppler ultrasound was performed on 82 patients included in the study and resistive index was calculated. A strong correlation between resistive index (RI) and serum creatinine level was found as calculated through Pearson's equation i-e 0.89. Thus making resistive index a strong predictor of transplanted kidney function and survival. Patients with RI>0.8 were older with mean age of 45.56, had raised serum creatinine level with mean value of 276.69 meu mol/l and had longer post transplant duration (mean 21.63 weeks). These patients also had other co-morbid diseases like diabetes mellitus and hypertension. The commonest post transplant complication was raised parenchymal echogenicity (30.5%), followed by perinephric collections (18.3%). Conclusion: RI on doppler ultrasound in renal transplant patients shows a strong correlation with serum creatinine levels. Renal transplant patients with elevated serum creatinine levels had raised resistive indices. (author)

  13. Ultrasound resistive index, power Doppler, and clinical parameters in established rheumatoid arthritis.

    Science.gov (United States)

    Bisi, Melissa Cláudia; do Prado, Aline Defaveri; Piovesan, Deise Marcela; Bredemeier, Markus; da Silveira, Inês Guimarães; Mendonça, José Alexandre; Staub, Henrique Luiz

    2017-04-01

    Ultrasonography (US) is a useful tool for the evaluation of sinovial vascularization and proliferation in rheumatoid arthritis (RA). Accordingly, resistive index (RI) on spectral Doppler (sD) US provides a quantitative analysis of vascular inflammation, but its utility in the evaluation of RA activity has not been established. Our objective was to determine the association of RI with other US parameters of synovitis and with clinical disease activity in established RA. Patients with positive power Doppler (pD) were included in a prospective cross-sectional study. Disease activity and disability were evaluated using the Disease Activity Score in 28-joints (DAS28) and Health Assessment Questionnaire (HAQ), respectively. Gray scale (GS) synovitis, pD, and sD analyses were performed by one of two examiners in wrists and the second and third metacarpophalangeal and proximal interphalangeal joints. The 10-joint GS and 10-joint pD scores and mean RI were then calculated. Weighted kappa (WK) values were employed to assess interobserver reability, and correlations were tested using the Spearman coefficient. Ninety-five RA patients (median duration of disease of 7 years and mean DAS28 of 4.32 ± 1.66) were included. WK values in real-time US were 0.77 for synovitis, 0.87 for pD, and 0.68 for RI. There were no significant correlations of RI with 10-joint GS, 10-joint pD, DAS28, joint counts, or HAQ (P > 0.10 for all tests). Patients in remission had a mean RI similar to those with high disease activity (0.62 ± 0.10, n = 15 versus 0.63 ± 0.13, n = 34, respectively). The addition of the RI score did not seem to improve US performance in patients with established RA.

  14. Changes of renal blood flow after ESWL: assessment by ASL MR imaging, contrast enhanced MR imaging, and renal resistive index.

    Science.gov (United States)

    Abd Ellah, Mohamed; Kremser, Christian; Pallwein, Leo; Aigner, Friedrich; Schocke, Michael; Peschel, Reinhard; Pedross, Florian; Pinggera, Germar-Michael; Wolf, Christian; Alsharkawy, Mostafa A M; Jaschke, Werner; Frauscher, Ferdinand

    2010-10-01

    The annual incidence of stone formation is increased in the industrialised world. Extracorporeal shockwave lithotripsy is a non-invasive effective treatment of upper urinary tract stones. This study is aimed to evaluate changes of renal blood flow in patients undergoing extracorporeal shock wave lithotripsy (ESWL) by arterial spin labeling (ASL) MR imaging, contrast enhanced dynamic MR imaging, and renal resistive index (RI). Thirteen patients with nephrolithiasis were examined using MR imaging and Doppler ultrasound 12h before and 12h after ESWL. ASL sequence was done for both kidneys and followed by contrast enhanced MR imaging. In addition RI Doppler ultrasound measurements were performed. A significant increase in RI (pESWL causes changes in RI and ASL MR imaging, which seem to reflect changes in renal blood flow. Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

  15. Serum cystatin C is an independent biomarker associated with the renal resistive index in patients with chronic kidney disease.

    Science.gov (United States)

    Ogawa-Akiyama, Ayu; Sugiyama, Hitoshi; Kitagawa, Masashi; Tanaka, Keiko; Onishi, Akifumi; Yamanari, Toshio; Morinaga, Hiroshi; Uchida, Haruhito Adam; Nakamura, Kazufumi; Ito, Hiroshi; Wada, Jun

    2018-01-01

    Cystatin C is a cysteine protease inhibitor that is produced by nearly all human cells. The serum level of cystatin C is a stronger predictor of the renal outcome and the risk of cardiovascular events than the creatinine level. The resistive index (RI) on renal Doppler ultrasonography is a good indicator of vascular resistance as well as the renal outcomes in patients with chronic kidney disease (CKD). However, it is unclear whether serum cystatin C is associated with signs of vascular dysfunction, such as the renal RI. We measured the serum cystatin C levels in 101 CKD patients and investigated the relationships between cystatin C and markers of vascular dysfunction, including the renal RI, ankle-brachial pulse wave velocity (baPWV), intima-media thickness (IMT), and cardiac function. The renal RI was significantly correlated with the serum cystatin C level (p < 0.0001, r = 0.6920). The serum cystatin C level was found to be a significant determinant of the renal RI (p < 0.0001), but not the baPWV, in a multivariate regression analysis. The multivariate odds ratio of the serum cystatin C level for a renal RI of more than 0.66 was statistically significant (2.92, p = 0.0106). The area under the receiver-operating characteristic curve comparing the sensitivity and specificity of cystatin C for predicting an RI of more than 0.66 was 0.882 (cutoff value: 2.04 mg/L). In conclusion, the serum cystatin C level is an independent biomarker associated with the renal RI in patients with CKD.

  16. Impairment of skin blood flow during post-occlusive reactive hyperhemy assessed by laser Doppler flowmetry correlates with renal resistive index.

    Science.gov (United States)

    Coulon, P; Constans, J; Gosse, P

    2012-01-01

    We lack non-invasive tools for evaluating the coronary and renal microcirculations. Since cutaneous Doppler laser exploration has evidenced impaired cutaneous microvascular responses in coronary artery disease and in impaired renal function, we wanted to find out if there was a link between the impairments in the cutaneous and renal microcirculations. To specify the significance of the rise in the renal resistive index (RI), which is still unclear, we also sought relations between RI and arterial stiffness. We conducted a cross-sectional controlled study in a heterogeneous population including hypertensive patients of various ages with or without a history of cardiovascular disease along with a healthy control group. The cutaneous microcirculation was evaluated by laser Doppler flowmetry of the post-occlusive reactive hyperhemy (PORH) and of the hyperhemy to heat. The renal microcirculation was evaluated by measurement of the RI. Arterial stiffness was evaluated from an ambulatory measurement of the corrected QKD(100-60) interval. We included 22 hypertensives and 11 controls of mean age 60.6 vs 40.8 years. In this population, there was a correlation between RI and basal zero to peak flow variation (BZ-PF) (r=-0.42; P=0.02) and a correlation between RI and rest flow to peak flow variation (RF-PF) (r=-0.44; P=0.01). There was also a significant correlation between RI and the corrected QKD(100-60) (r=-0.47; P=0.01). The significant correlation between PORH parameters and RI indicates that the functional modifications of the renal and cutaneous microcirculations tend to evolve in parallel during ageing or hypertension. The relation between RI and arterial stiffness shows that RI is a compound index of both renal microvascular impairment and the deterioration of macrovascular mechanics.

  17. A novel surrogate index for hepatic insulin resistance.

    LENUS (Irish Health Repository)

    Vangipurapu, J

    2011-03-01

    In epidemiological and genetic studies surrogate indices are needed to investigate insulin resistance in different insulin-sensitive tissues. Our objective was to develop a surrogate index for hepatic insulin resistance.

  18. Identification of Major Risk Sources for Surface Water Pollution by Risk Indexes (RI) in the Multi-Provincial Boundary Region of the Taihu Basin, China

    Science.gov (United States)

    Yao, Hong; Li, Weixin; Qian, Xin

    2015-01-01

    Environmental safety in multi-district boundary regions has been one of the focuses in China and is mentioned many times in the Environmental Protection Act of 2014. Five types were categorized concerning the risk sources for surface water pollution in the multi-provincial boundary region of the Taihu basin: production enterprises, waste disposal sites, chemical storage sites, agricultural non-point sources and waterway transportations. Considering the hazard of risk sources, the purification property of environmental medium and the vulnerability of risk receptors, 52 specific attributes on the risk levels of each type of risk source were screened out. Continuous piecewise linear function model, expert consultation method and fuzzy integral model were used to calculate the integrated risk indexes (RI) to characterize the risk levels of pollution sources. In the studied area, 2716 pollution sources were characterized by RI values. There were 56 high-risk sources screened out as major risk sources, accounting for about 2% of the total. The numbers of sources with high-moderate, moderate, moderate-low and low pollution risk were 376, 1059, 101 and 1124, respectively, accounting for 14%, 38%, 5% and 41% of the total. The procedure proposed could be included in the integrated risk management systems of the multi-district boundary region of the Taihu basin. It could help decision makers to identify major risk sources in the risk prevention and reduction of surface water pollution. PMID:26308032

  19. Identification of Major Risk Sources for Surface Water Pollution by Risk Indexes (RI) in the Multi-Provincial Boundary Region of the Taihu Basin, China.

    Science.gov (United States)

    Yao, Hong; Li, Weixin; Qian, Xin

    2015-08-21

    Environmental safety in multi-district boundary regions has been one of the focuses in China and is mentioned many times in the Environmental Protection Act of 2014. Five types were categorized concerning the risk sources for surface water pollution in the multi-provincial boundary region of the Taihu basin: production enterprises, waste disposal sites, chemical storage sites, agricultural non-point sources and waterway transportations. Considering the hazard of risk sources, the purification property of environmental medium and the vulnerability of risk receptors, 52 specific attributes on the risk levels of each type of risk source were screened out. Continuous piecewise linear function model, expert consultation method and fuzzy integral model were used to calculate the integrated risk indexes (RI) to characterize the risk levels of pollution sources. In the studied area, 2716 pollution sources were characterized by RI values. There were 56 high-risk sources screened out as major risk sources, accounting for about 2% of the total. The numbers of sources with high-moderate, moderate, moderate-low and low pollution risk were 376, 1059, 101 and 1124, respectively, accounting for 14%, 38%, 5% and 41% of the total. The procedure proposed could be included in the integrated risk management systems of the multi-district boundary region of the Taihu basin. It could help decision makers to identify major risk sources in the risk prevention and reduction of surface water pollution.

  20. Identification of Major Risk Sources for Surface Water Pollution by Risk Indexes (RI in the Multi-Provincial Boundary Region of the Taihu Basin, China

    Directory of Open Access Journals (Sweden)

    Hong Yao

    2015-08-01

    Full Text Available Environmental safety in multi-district boundary regions has been one of the focuses in China and is mentioned many times in the Environmental Protection Act of 2014. Five types were categorized concerning the risk sources for surface water pollution in the multi-provincial boundary region of the Taihu basin: production enterprises, waste disposal sites, chemical storage sites, agricultural non-point sources and waterway transportations. Considering the hazard of risk sources, the purification property of environmental medium and the vulnerability of risk receptors, 52 specific attributes on the risk levels of each type of risk source were screened out. Continuous piecewise linear function model, expert consultation method and fuzzy integral model were used to calculate the integrated risk indexes (RI to characterize the risk levels of pollution sources. In the studied area, 2716 pollution sources were characterized by RI values. There were 56 high-risk sources screened out as major risk sources, accounting for about 2% of the total. The numbers of sources with high-moderate, moderate, moderate-low and low pollution risk were 376, 1059, 101 and 1124, respectively, accounting for 14%, 38%, 5% and 41% of the total. The procedure proposed could be included in the integrated risk management systems of the multi-district boundary region of the Taihu basin. It could help decision makers to identify major risk sources in the risk prevention and reduction of surface water pollution.

  1. Evaluation of renal resistive index in cirrhotic patients for predicting the hepatirenal syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Baek, Seung Yon; Kim, Hyae young; Yi, Sun Young [Ewha WoMans Univ. Mokdong Hospital, Seoul (Korea, Republic of)

    1996-04-01

    To evaluate the usefulness of renal resistive index(RI) in patients with liver cirrhosis as an indicator for predicting hepatorenal syndrome. Renal RIs of thirty cirrhotic patients were analyzed using the gray-scale and Doppler ultrasonograms. As a control group, eight normal subjects were included. Renal RIs were measured at three sites of interlobar or arcuate arteries of both kidneys. The patients were divided into three groups (A, B, or C) according to the Child-Turcotte-Pugh classification and their serum BUN and creatinine levels were compared. We determined whether RIs of normal controls differed from those of cirrhotic patients or whether RIs of cirrhotic patients correlated with the Child-Turcotte-Pugh classification or BUN and creatinine levels. Mean RIs(0.63 {+-}0.33) of normal subjects were statistically different from those(0.67 {+-} 0.05) of cirrhotic patients(P=0.009). RIs of group A(n=6), B(n=9) and C(n=15) were 0.65 {+-} 0.03, 0.65 {+-} 0.04 and 0.70 {+-} 0.04, respectively. The ANOVA test revealed statistically significant differences between the three groups(F ratio=4.472, P=0.021). RIs did not correlate with BUN or creatinine levels. RI could be used as an index for predicting hepatorenal syndrome before the renal function becomes impaired.

  2. Evaluation of renal resistive index in cirrhotic patients for predicting the hepatirenal syndrome

    International Nuclear Information System (INIS)

    Baek, Seung Yon; Kim, Hyae young; Yi, Sun Young

    1996-01-01

    To evaluate the usefulness of renal resistive index(RI) in patients with liver cirrhosis as an indicator for predicting hepatorenal syndrome. Renal RIs of thirty cirrhotic patients were analyzed using the gray-scale and Doppler ultrasonograms. As a control group, eight normal subjects were included. Renal RIs were measured at three sites of interlobar or arcuate arteries of both kidneys. The patients were divided into three groups (A, B, or C) according to the Child-Turcotte-Pugh classification and their serum BUN and creatinine levels were compared. We determined whether RIs of normal controls differed from those of cirrhotic patients or whether RIs of cirrhotic patients correlated with the Child-Turcotte-Pugh classification or BUN and creatinine levels. Mean RIs(0.63 ±0.33) of normal subjects were statistically different from those(0.67 ± 0.05) of cirrhotic patients(P=0.009). RIs of group A(n=6), B(n=9) and C(n=15) were 0.65 ± 0.03, 0.65 ± 0.04 and 0.70 ± 0.04, respectively. The ANOVA test revealed statistically significant differences between the three groups(F ratio=4.472, P=0.021). RIs did not correlate with BUN or creatinine levels. RI could be used as an index for predicting hepatorenal syndrome before the renal function becomes impaired

  3. Changes of renal blood flow after ESWL: Assessment by ASL MR imaging, contrast enhanced MR imaging, and renal resistive index

    Energy Technology Data Exchange (ETDEWEB)

    Abd Ellah, Mohamed, E-mail: dr_m_hamdy2006@hotmail.co [Innsbruck Medical University, Radiology Dept., Anich St. 35, 6020 Innsbruck (Austria); Kremser, Christian, E-mail: christian.kremser@i-med.ac.a [Innsbruck Medical University, Radiology Dept., Anich St. 35, 6020 Innsbruck (Austria); Pallwein, Leo, E-mail: leo.pallwein-prettner@uki.a [Innsbruck Medical University, Radiology Dept., Anich St. 35, 6020 Innsbruck (Austria); Aigner, Friedrich, E-mail: friedrich.Aigner@uki.a [Innsbruck Medical University, Radiology Dept., Anich St. 35, 6020 Innsbruck (Austria); Schocke, Michael, E-mail: michael.schocke@i-med.ac.a [Innsbruck Medical University, Radiology Dept., Anich St. 35, 6020 Innsbruck (Austria); Peschel, Reinhard, E-mail: reinhard.peschel@uki.a [Innsbruck Medical University, Urology Dept., Anich St. 35, 6020 Innsbruck (Austria); Pedross, Florian, E-mail: florian.pedross@i-med.ac.a [Innsbruck Medical University, Medical Statistics Dept., Anich St. 35, 6020 Innsbruck (Austria); Pinggera, Germar-Michael, E-mail: germar.pinggera@uki.a [Innsbruck Medical University, Urology Dept., Anich St. 35, 6020 Innsbruck (Austria); Wolf, Christian, E-mail: christian.wolf@bkh-reutte.a [Innsbruck Medical University, Radiology Dept., Anich St. 35, 6020 Innsbruck (Austria); Alsharkawy, Mostafa A.M., E-mail: drmostafamri@yahoo.co [Assiut University, Radiology Dept., Assiut (Egypt); Jaschke, Werner, E-mail: werner.jaschke@i-med.ac.a [Innsbruck Medical University, Radiology Dept., Anich St. 35, 6020 Innsbruck (Austria); Frauscher, Ferdinand, E-mail: ferdinand.frauscher@uki.a [Innsbruck Medical University, Radiology Dept., Anich St. 35, 6020 Innsbruck (Austria)

    2010-10-15

    The annual incidence of stone formation is increased in the industrialised world. Extracorporeal shockwave lithotripsy is a non-invasive effective treatment of upper urinary tract stones. This study is aimed to evaluate changes of renal blood flow in patients undergoing extracorporeal shock wave lithotripsy (ESWL) by arterial spin labeling (ASL) MR imaging, contrast enhanced dynamic MR imaging, and renal resistive index (RI). Thirteen patients with nephrolithiasis were examined using MR imaging and Doppler ultrasound 12 h before and 12 h after ESWL. ASL sequence was done for both kidneys and followed by contrast enhanced MR imaging. In addition RI Doppler ultrasound measurements were performed. A significant increase in RI (p < 0.001) was found in both treated and untreated kidneys. ASL MR imaging also showed significant changes in both kidneys (p < 0.001). Contrast enhanced dynamic MR imaging did not show significant changes in the kidneys. ESWL causes changes in RI and ASL MR imaging, which seem to reflect changes in renal blood flow.

  4. Transgenic fertile Scoparia dulcis L., a folk medicinal plant, conferred with a herbicide-resistant trait using an Ri binary vector.

    Science.gov (United States)

    Yamazaki, M; Son, L; Hayashi, T; Morita, N; Asamizu, T; Mourakoshi, I; Saito, K

    1996-01-01

    Transgenic herbicide-resistant Scoparia dulcis plants were obtained by using an Ri binary vector system. The chimeric bar gene encoding phosphinothricin acetyltransferase flanked by the promoter for cauliflower mosaic virus 35S RNA and the terminal sequence for nopaline synthase was introduced in the plant genome by Agrobacterium-mediated transformation by means of scratching young plants. Hairy roots resistant to bialaphos were selected and plantlets (R0) were regenerated. Progenies (S1) were obtained by self-fertilization. The transgenic state was confirmed by DNA-blot hybridization and assaying of neomycin phosphotransferase II. Expression of the bar gene in the transgenic R0 and S1 progenies was indicated by the activity of phosphinothricin acetyltransferase. Transgenic plants accumulated scopadulcic acid B, a specific secondary metabolite of S. dulcis, in amounts of 15-60% compared with that in normal plants. The transgenic plants and progenies showed resistant trait towards bialaphos and phosphinothricin. These results suggest that an Ri binary system is one of the useful tools for the transformation of medicinal plants for which a regeneration protocol has not been established.

  5. Spectral Doppler Waveforms for Diagnosis of Appendicitis: Potential Utility of Point Peak Systolic Velocity and Resistive Index Values.

    Science.gov (United States)

    Shin, Lewis K; Jeffrey, R Brooke; Berry, Gerald J; Olcott, Eric W

    2017-12-01

    Purpose To test the hypothesis that appendiceal spectral Doppler waveforms can distinguish patients with and patients without appendicitis. Materials and Methods In this retrospective study, Doppler waveforms were obtained from intramural appendiceal arteries identified with color Doppler imaging in 60% (93 of 155) of consecutive patients whose appendices were visualized at graded compression ultrasonography (US) performed for suspected appendicitis (53 male and 40 female; age, 1-56 years; mean, 14.5 years) over the 5-month period from November 2015 through March 2016. Point, non-angle-corrected peak systolic velocity (PSV) and resistive index (RI) values were compared between patients with and patients without appendicitis by utilizing histopathologically proven appendicitis and 6-week clinical follow-up as diagnostic reference standards. Data were assessed by using the Student t test, exact binomial distribution, two-sample test of proportions, and receiver operating characteristic analysis. Results Among the 93 patients, 36 (38.7%) had proven appendicitis (mean PSV, 19.7 cm/sec; mean RI, 0.69) and 57 patients (61.2%) did not (mean PSV, 7.1 cm/sec, P appendicitis was 0.97 (95% confidence interval [CI]: 0.95, 1.00) for PSV and 0.86 (95% CI: 0.78, 0.95; P = .011) for RI. Chosen discriminatory criteria of PSV greater than 10 cm/sec and RI greater than 0.65 yielded specificity for appendicitis of 94.7% and 96.5% with sensitivity of 88.9% and 63.9% (P = .013) and negative predictive value of 93.1% and 80.9% (P = .045), respectively. Original clinical graded compression US interpretations based on established US findings demonstrated specificity of 96.2% and sensitivity of 100.0%. Considering the subset of 20 patients whose maximum outer diameter measured 6-8 mm, the discriminatory criteria of PSV greater than 10 cm/sec and RI greater than 0.65 yielded specificity for appendicitis of 88.9% each, with sensitivity of 100.0% and 63.6% and negative predictive value of 100

  6. Intra and interobserver variability of renal allograft ultrasound volume and resistive index measurements

    International Nuclear Information System (INIS)

    Mancini, Marcello; Liuzzi, Raffaele; Daniele, Stefania; Raffio, Teresa; Salvatore, Marco; Sabbatini, Massimo; Cianciaruso, Bruno; Ferrara, Liberato Aldo

    2005-01-01

    Purpose: Aim of the presents study was to evaluate the repeatability and reproducibility of the Doppler Resistive Index (R.I.) and the Ultrasound renal volume measurement in renal transplants. Materials and methods: Twenty -six consecutive patients (18 men, 8 women) mean age of 42,8±12,4 years (M±SD)(range 22-65 years) were studied twice by each of two trained sonographers using a color Doppler ultrasound scanner. Twelve of them had a normal allograft function (defined as stable serum creatinine levels ≤123,76 μmol/L), whilst the remaining 14 had decreased allograft function (serum creatinine 132.6-265.2 μmol/L). Results were given as mean of 6 measurements performed at upper, middle and lower pole of the kidney. Intra- and interobserver variability was assessed by the repeatability coefficient and coefficient of variation (CV). Results: Regarding Resistive Index measurement, repeatability coefficient was between 0.04 and 0.06 and the coefficient of variation was [it

  7. The Umbilical Artery Resistive Index and the Cerebro-Placental ...

    African Journals Online (AJOL)

    The Umbilical Artery Resistive Index and the Cerebro-Placental Ratio as a Predictor of Adverse Foetal Outcome in Patients with Hypertensive Disorders of ... East and Central African Journal of Surgery ... Background: Hypertensive disorders of pregnancy causes adverse effects both the maternal and faetal circulations.

  8. Using a constructive pavement texture index for skid resistance screening

    Directory of Open Access Journals (Sweden)

    Chia-Pei Chou

    2017-07-01

    Full Text Available Skid resistance measurement is one of the major measurements used to assess road safety. Typical devices used for measuring skid resistance include single point checking type and continuous measurements type. However, conducting periodic full roadway network skid resistance survey can be a relatively time consuming and difficult task because of the limited water carrying capacity used by all kinds of devices, including the continuous types. On the contrary, measurement of pavement surface texture can be conducted easily and continuously by most profilers. This research investigates the relation between pavement skid resistance and surface texture. The focus is on the development of a texture index that can serve as a screening indicator to filter out the high-risk pavement sections for further skid resistance measurement. Two measuring devices, GripTester (GT and National Taiwan University laser profiler (NTU Profiler, were used to collect data on pavement skid resistance and texture in a network of 555 sections, respectively. The pavement texture index of the mean difference of elevation (MDE is calculated at a 1 mm profile interval, which is a very promising indicator to represent pavement skid resistance. Through a sensitivity study, the MDE threshold of 0.15 mm is observed to provide a relatively reasonable screening function that filters out 29.01% of the entire surveyed network for further skid resistance inspection. It averted more than 70% skid resistance measurement capacity of the entire network. The accuracy of correct judgment by the selected threshold is about 80%, only 3.78% of roadway sections considered for further inspection of the recommended list are not included. Keywords: Skid resistance, Pavement texture, Macrotexture, Laser profiler, GripTester

  9. Triglycerides and glucose index: a useful indicator of insulin resistance.

    Science.gov (United States)

    Unger, Gisela; Benozzi, Silvia Fabiana; Perruzza, Fernando; Pennacchiotti, Graciela Laura

    2014-12-01

    Insulin resistance assessment requires sophisticated methodology of difficult application. Therefore, different estimators for this condition have been suggested. The aim of this study was to evaluate the triglycerides and glucose (TyG) index as a marker of insulin resistance and to compare it to the triglycerides/HDL cholesterol ratio (TG/HDL-C), in subjects with and without metabolic syndrome (MS). An observational, cross-sectional study was conducted on 525 adults of a population from Bahia Blanca, Argentina, who were divided into two groups: with MS (n=89) and without MS (n=436). The discriminating capacities for MS of the TyG index, calculated as Ln (TG [mg/dL] x glucose [mg/dL]/2), and the TG/HDL-C ratio were evaluated. Pre-test probability for MS was 30%. The mean value of the TyG index was higher in the group with MS as compared to the group without MS and its correlation with the TG/HDL-C ratio was good. The cut-off values for MS in the overall population were 8.8 for the TyG index (sensitivity=79%, specificity=86%), and 2.4 for the TG/HDL-C ratio (sensitivity=88%, specificity=72%). The positive likelihood ratios and post-test probabilities for these parameters were 5.8 vs 3.1 and 72% vs 58% respectively. The cut-off point for the TyG index was 8.8 in men and 8.7 in women; the respective values for TG/C-HDL were 3.1 in men and 2.2 in women. The TyG index was a good discriminant of MS. Its simple calculation warrants its further study as an alternative marker of insulin resistance. Copyright © 2014 SEEN. Published by Elsevier Espana. All rights reserved.

  10. Use of renal resistive index and semi-rigid ureteroscopy for managing symptomatic persistent hydronephrosis during pregnancy.

    Science.gov (United States)

    Atar, Murat; Bozkurt, Yasar; Soylemez, Haluk; Penbegul, Necmettin; Sancaktutar, Ahmet Ali; Bodakci, Mehmet Nuri; Hatipoglu, Namik Kemal; Hamidi, Cihad; Ozler, Ali

    2012-01-01

    The aim of this study was to evaluate the use of Doppler ultrasonography (DUS) and semi-rigid ureteroscopy (URS) for managing symptomatic persistent hydronephrosis during pregnancy. The study included 19 pregnant patients with unilateral symptomatic persistent hydronephrosis. All pregnant patients were assessed with conventional ultrasonography (US) followed by DUS for both kidneys. The mean patient age was 26 years (range 19-40), and the gestational period was 24 weeks (range 16-33). There was a significantly higher mean resistive index in the kidneys with ureteral obstruction than in the contralateral normal kidneys. Spinal anesthesia was performed on 18 patients, while general anesthesia was performed on 1 patient. Endoscopically stones were found in 17 patients (89.5%), while no stone was found in 2 patients (10.5%). The stones were fragmented by holmium laser and retracted with forceps. After lithotripsy, a ureteral JJ stent was inserted in 8 of 17 (47%) patients with ureteral stones. Intraoperatively, there were no obstetric complications, while ureteral perforation was seen in one patient. Two patients are still pregnant at the time of this writing, and 17 babies were born normally. Both RI and ΔRI increase in unilateral symptomatic persistent hydronephrosis during pregnancy. Semi-rigid URS can be used successfully for diagnosis and treatment in these patients. Copyright © 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  11. Directly patternable high refractive index ferroelectric sol–gel resist

    Energy Technology Data Exchange (ETDEWEB)

    Garoli, D., E-mail: denis.garoli@iit.it [Istituto Italiano di Tecnologia, Via Morego 16, 16136 Genova (Italy); Della Giustina, G. [Industrial Engineering Department, University of Padova and INSTM, Via Marzolo 9, 35131 Padova (Italy)

    2015-08-15

    The development of a ferroelectric negative tone sol–gel resist for Ultraviolet (UV) and Electron Beam (EB) lithography is presented. A new system based on Lead Zirconate Titanate (PZT, with formula PbZr{sub 0.52}Ti{sub 0.48}O{sub 3}) was synthesized by sol–gel method. The lithographic performances were investigated and several structures spanning from the micron range down to less than 50 nm have been achieved by UV and EB lithography. The system interaction with UV light and Electron beam was thoroughly characterized by FT-IT spectroscopy. The exposed PZT was annealed at high temperatures in order to study the crystalline phase evolution, the optical constants values and stability of patterned structures. After exposure and annealing, the refractive index of the material can vary from 1.68 up to 2.33 (@400 nm), while the ferroelectric behaviour seems to be maintained after high temperature annealing. These results suggest a possible application of PZT resist not only as ferroelectric but also as nanopatternable high refractive index material. Moreover, direct nanopatterning by means of Focused Ion Beam (FIB) lithography was verified and the potentiality for the preparation of high aspect ratio hollow nanostructures will be presented. - Highlights: • A new formula directly patternable PZT high refractive index resist is presented. • The gel is sensitive to both UV and electron beam exposure. • The refractive index can vary from 1.68 up to 2.33 (@400 nm). • Direct nanopatterning by means of Focused Ion Beam (FIB) lithography was verified. • High aspect ratio hollow nanostructures will be presented.

  12. The value of the renal resistive index in the measurement of renal perfusion before and after extracorporal shock wave lithotripsy in correlation to the scintigraphy, to the magnetic resonance perfusion imaging and to big-endothelin values

    International Nuclear Information System (INIS)

    Palwein-Prettner, L.

    1999-07-01

    Purpose: the goal of this study was to evaluate effects of extracorporeal shock wave lithotripsy (ESWL) on the renal perfusion using the resistive index (RI), perfusion scintigraphy, magnetic resonance (MR) perfusion imaging and plasma big-endothelin (big-ET-1) values. Method/materials: In 21 patients divided in 3 age-groups the RI was measured before and 1,3,6 and 24 hours after ESWL. Big-ET-1, a potent vasoconstrictor peptid was correlated with the RI values. The RI and Big-ET-1 results was compared to the results of the MR perfusion imaging and the scintigraphy, the gold-standard method. Results: The RI of the treated kidneys increased significantly from 0,64±0,05 to 0,72±0,08 after the ESWL (p<0,001) and in the untreated kidneys from 0,63±0,05 to 0,68±0,09 (p=0,003). The hightest age group shows the most significant increase. The Big-ET-values also increased only in this age group significantly from 0,78±0,24 fmol/l to 1,58±0,52 fmol/l. In the scintigraphy the decrease of the renal plasma flow (RPF) in this age group was most significant. The MR perfusion Imaging shows in all age groups significant decrease (p<0,001). Conclusion: we conclude that the ESWL causes considerable renal parenchymal damage only in the elderly patients. The following changes in renal perfusion were measured very sensitively with the RI which had a good correlation to the results of the perfusion scintigraphy and the MR perfusion imaging. Further studies with larger series have to evaluate these results. (author)

  13. The predictive value of renal vascular resistance for late renal allograft loss

    NARCIS (Netherlands)

    de Vries, APJ; van Son, WJ; van der Heide, JJH; Ploeg, RJ; Navis, G; de Jong, PE; Gans, ROB; Bakker, SJL; Gansevoort, RT

    The renal artery resistance index (RI), assessed by Doppler ultrasonography, was recently identified as a new risk marker for late renal allograft loss. This finding requires confirmation since RI in that study was not measured at predetermined time points and ultrasonography is operator-dependent.

  14. The predictive value of renal vascular resistance for late renal allograft loss

    NARCIS (Netherlands)

    de Vries, A. P. J.; van Son, W. J.; Homan van der Heide, J. J.; Ploeg, R. J.; Navis, G.; de Jong, P. E.; Gans, R. O. B.; Bakker, S. J. L.; Gansevoort, R. T.

    2006-01-01

    The renal artery resistance index (RI), assessed by Doppler ultrasonography, was recently identified as a new risk marker for late renal allograft loss. This finding requires confirmation since RI in that study was not measured at predetermined time points and ultrasonography is operator-dependent.

  15. Validation of insulin resistance indexes in a stable renal transplant population

    NARCIS (Netherlands)

    Oterdoom, Leendert H.; de Vries, Aiko P. J.; van Son, Willem J.; Homan van der Heide, Jaap J.; Ploeg, Rutger J.; Gansevoort, Ron T.; de Jong, Paul E.; Gans, Rijk O. B.; Bakker, Stephan J. L.

    2005-01-01

    The purpose of this study was to investigate the validity of established insulin resistance indexes, based on fasting blood parameters, in a stable renal transplant population. Fasting insulin, homeostasis model assessment (HOMA), the quantitative insulin sensitivity check index (QUICKI), and

  16. Renal resistive index and mortality in chronic kidney disease.

    Science.gov (United States)

    Toledo, Clarisse; Thomas, George; Schold, Jesse D; Arrigain, Susana; Gornik, Heather L; Nally, Joseph V; Navaneethan, Sankar D

    2015-08-01

    Renal resistive index (RRI) measured by Doppler ultrasonography is associated with cardiovascular events and mortality in hypertensive, diabetic, and elderly patients. We studied the factors associated with high RRI (≥0.70) and its associations with mortality in chronic kidney disease patients without renal artery stenosis. We included 1962 patients with an estimated glomerular filtration rate of 15 to 59 mL/min per 1.73 m(2) who also had RRI measured (January 1, 2005, to October 2011) from an existing chronic kidney disease registry. Participants with renal artery stenosis (60%-99% or renal artery occlusion) were excluded. Multivariable logistic regression model was used to study factors associated with high RRI (≥0.70), and its association with mortality was studied using Kaplan-Meier plots and Cox proportional hazards model. Hypertension was prevalent in >90% of the patients. In the multivariable logistic regression, older age, female sex, diabetes mellitus, coronary artery disease, peripheral vascular disease, higher systolic blood pressure, and the use of β blockers were associated with higher odds of having RRI≥0.70. During a median follow-up of 2.2 years, 428 patients died. After adjusting for covariates, RRI≥0.70 was associated with increased mortality (adjusted hazard ratio, 1.29; 95% confidence interval, 1.02-1.65; Pchronic kidney disease. Noncardiovascular/non-malignancy-related deaths were higher in those with RRI≥0.70. RRI≥0.70 is associated with higher mortality in hypertensive chronic kidney disease patients without clinically significant renal artery stenosis after accounting for other significant risk factors. Its evaluation may allow early identification of those who are at risk thereby potentially preventing or delaying adverse outcomes. © 2015 American Heart Association, Inc.

  17. The renal arterial resistive index and stage of chronic kidney disease in patients with renal allograft

    DEFF Research Database (Denmark)

    Winther, Stine O; Thiesson, Helle C; Poulsen, Lene N

    2012-01-01

    The study investigated the optimal threshold value of renal arterial resistive index as assessed by Doppler ultrasonography determining chronic kidney disease stage 4 or higher in patients with renal allograft.......The study investigated the optimal threshold value of renal arterial resistive index as assessed by Doppler ultrasonography determining chronic kidney disease stage 4 or higher in patients with renal allograft....

  18. RI scintigraphy in myasthenia gravis

    International Nuclear Information System (INIS)

    Kuroda, Yoshikazu; Miyamoto, Mariko; Maki, Masako; Yamazaki, Toshiro.

    1982-01-01

    35 cases of myasthenia gravis were studied with RI scintigraphy. 67 Ga-citrate was used in 34 patients and 76 Se-selenomethionine in 5 patients for thymus scintigraphy. RI scintigram was negative in non-tumorous thymus, regardless of the severity of illness and it was positive in seven of nine patients with thymomas. RI accumulation in thymus was found both in benign and malignant thymomas. RI seems to accumulated in lymphocytic and mixed thymus more than epithelial type. (author)

  19. RI scintigraphy in myasthenia gravis

    Energy Technology Data Exchange (ETDEWEB)

    Kuroda, Yoshikazu; Miyamoto, Mariko (Tokyo Metropolitan Fuchu Hospital (Japan)); Maki, Masako; Yamazaki, Toshiro

    1982-10-01

    35 cases of myasthenia gravis were studied with RI scintigraphy. /sup 67/Ga-citrate was used in 34 patients and /sup 76/Se-selenomethionine in 5 patients for thymus scintigraphy. RI scintigram was negative in non-tumorous thymus, regardless of the severity of illness and it was positive in seven of nine patients with thymomas. RI accumulation in thymus was found both in benign and malignant thymomas. RI seems to accumulated in lymphocytic and mixed thymus more than epithelial type.

  20. Validation of insulin resistance indexes in a stable renal transplant population

    NARCIS (Netherlands)

    Oterdoom, LH; De Vries, APJ; Van Son, WJ; Van Der Heide, JJH; Ploeg, RJ; Gansevoort, RT; De Jong, PE; Gans, ROB; Bakker, SJL

    2005-01-01

    OBJECTIVE - The purpose of this study was to investigate the validity of established insulin resistance indexes, based on fasting blood parameters, in a stable renal transplant population. RESEARCH DESIGN AND METHODS - Fasting insulin, homeostasis model assessment (HOMA), the quantitative insulin

  1. Better Renal Resistive Index Profile in Subjects with Beta Thalassemia Minor .

    Science.gov (United States)

    Basut, Fahrettin; Keşkek, Şakir Özgür; Gülek, Bozkurt

    2018-05-03

    Beta thalassaemia minor is a common genetic disorder without any characteristic symptoms except mild anemia. It is found to be associated with some cardiovascular risk factors such as insulin resistance and diabetes mellitus. The renal resistive index (RRI) is a measure of renal arterial resistance to blood flow. The aim of this study was to evaluate the renal resistive index in subjects with beta thalassaemia minor (BTM). A total of 253 subjects were included in this cross-sectional study. The study group consisted of 148 subjects with BTM and the control group consisted of 105 healthy subjects. Beta thalassaemia minor was diagnosed by complete blood count and hemoglobin electrophoresis. Blood pressure measurement and biochemical tests were performed. Renal resistive index of all subjects was measured using renal Doppler ultrasonography. Subjects with beta thalassemia minor had lower renal resistive indices compared to healthy subjects (0.58 ± 0.04 vs. 0.60 ± 0.06, p = 0.0016). Additionally, the RRI levels of subjects with BTM were correlated with systolic blood pressure (p = 0.017, r = 0.194). In this study, lower renal resistive index was found in subjects with BTM. This may be associated with decreased vascular resistance and blood viscosity in these subjects. ©2018The Author(s). Published by S. Karger AG, Basel.

  2. Pelvis dilatation and mucosal thickening of transplanted kidney: comparative study of resistive index and ultrasonographic finding

    International Nuclear Information System (INIS)

    Kim, Myung Joon; Yoo, Hyung Sik; Lee, Jong Tae; Kim, Yu Seun; Park, Ki Il

    1992-01-01

    Diagnostic ability of duplex Doppler ultrasonography relying on resistive index is limited when clinical symptoms and signs of rejection are subtle or renal dysfunction is caused by other conditions such as urinary tract infection. To investigate the significance in the changes of renal pelvis, a combined analysis of resistive index and ultrasonographic findings in cases of renal pelvis dilatation and mucosal thickening was undertaken. A mean resistive index was calculated from Doppler measurements of the main, segmental and interlobar arteries. The cause of mucosal thickening was retrospectively analysed using the clinical and laboratory findings. Twenty three cases of renal pelvis dilatation and 17 cases of mucosal thickening were found in a total of 159 renal transplantation cases. In 14 of the 23 cases with renal pelvis dilatation, renal function was normal and their mean resistive index was 0.64 ± 0.04. Pelvis and ureter dilatation caused by ureteral stenosis or compression was demonstrated in 6 cases and their mean resistive index (0.72 ± 0.05) was increased. Mucosal thickening of renal pelvis was found in 7 of 32 cases with acute injection and in 2 of 13 cases with chronic rejection, but their mean resistive index was not different from that of the cases without pelvic mucosal changes. Three cases of acute rejection associated with urinary tract infection and 2 cases of chronic rejection in whom resistive indices were indeterminate, but mucosal thickening of the renal pelvis was prominent at ultrasonography. In renal transplant patients having indeterminate resistive index and mucosal thickening of the renal pelvis, ultrasonographic features must be correlated with the clinical and laboratory findings for an accurate diagnosis and treatment of renal dysfunction

  3. Hemodynamic comparison of mild and severe preeclampsia: concept of stroke systemic vascular resistance index.

    Science.gov (United States)

    Scardo, J; Kiser, R; Dillon, A; Brost, B; Newman, R

    1996-01-01

    Our purpose was to compare baseline hemodynamic parameters of mild and severe preeclampsia. Patients admitted to the Medical University Labor and Delivery Unit with the diagnosis of preeclampsia who had not received prior antihypertensive or magnesium sulfate therapy were recruited for noninvasive hemodynamic monitoring with thoracic electrical bioimpedance. After stabilization in the lateral recumbent position, hemodynamic monitoring was begun. Baseline hemodynamic parameters, mean arterial pressure (MAP), heart rate (HR), systemic vascular resistance index (SVRI), cardiac index (CI), and stroke index (SI) were recorded. Stroke systemic vascular resistance index (SSVRI), the resistance imposed by vasculature on each beat of the heart, was calculated for each patient by multiplying SVRI by HR. For statistical analysis, unpaired Student's t-tests (two-tailed) were utilized (P preclampsia appears to be a more intensely vasoconstricted state than mild preeclampsia. Although CI is inversely proportional to SVRI, increased HR in severe preeclampsia prevents this expected decrease in cardiac output.

  4. Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents.

    Science.gov (United States)

    Kang, B; Yang, Y; Lee, E Y; Yang, H K; Kim, H-S; Lim, S-Y; Lee, J-H; Lee, S-S; Suh, B-K; Yoon, K-H

    2017-05-01

    Our aim was to investigate the association between the triglycerides/glucose index (TyG index) and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) in the prediction of insulin resistance (IR) among adolescents. We conducted a cross-sectional study among 221 Korean adolescents (168 males and 53 females aged 9-13 years) from May to June 2014 in Chung-ju city. The TyG index was calculated as ln [triglycerides (mg dl -1 ) × fasting glucose (mg dl -1 )/2]. IR was defined using HOMA-IR >95th percentile for age and sex. In the IR group, weight, body mass index (BMI), waist circumference, body fat, fasting insulin, fasting plasma glucose, triglyceride levels and triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) were significantly higher than that in the non-IR group. The TG index was significantly different between the IR group (n=22) and non-IR group (n=199), at 8.43±0.45 and 8.05±0.41, respectively (Pindex was well correlated with HOMA-IR (r=0.41; Pindex for diagnosis of insulin resistance was 8.18. The TyG index is a simple, cost-effective surrogate marker of insulin resistance among adolescents compared with HOMA-IR.

  5. Relationship of visfatin level to pancreatic endocrine hormone level, HOMA-IR index, and HOMA β-cell index in overweight women who performed hydraulic resistance exercise.

    Science.gov (United States)

    Ha, Chang Ho; Swearingin, Brenda; Jeon, Yong Kyun

    2015-09-01

    [Purpose] This study aimed to examine the correlation of visfatin level to pancreatic endocrine hormone level, homeostasis model assessment of insulin resistance (HOMA-IR) index, and HOMA β-cell index in hydraulic resistance exercise. Furthermore, it investigated the relationship between visfatin level and other variables affected by exercise in overweight women. [Subjects and Methods] The exercise group trained for 12 weeks, 70 minutes/day, 5 days/week. Visfatin level, pancreatic endocrine hormone level, HOMA-IR index, and HOMA β-cell index were measured before and after the intervention. Based on the blood insulin and glucose concentrations, HOMA-IR index, the indicator of insulin resistance, and HOMA β-cell index, the indicator of insulin secretion level, were assessed. [Results] Interaction effects on visfatin level, insulin level, HOMA-IR index, and HOMA β-cell index were observed. Interaction effects on glucagon and glucose levels were not observed between the intervention groups. The correlations of visfatin level to insulin, glucagon, and glucose levels, and HOMA-IR and HOMA β-cell indexes were not significant for any of the subjects. [Conclusion] Therefore, the 12-week resistance exercise affected body composition, visfatin level, insulin level, HOMA-IR index, and HOMA β-cell index. Finally, visfatin was not related to insulin, glucagon, and glucose levels, and HOMA-IR and HOMA β-cell indexes.

  6. Resistance and Security Index of Networks: Structural Information Perspective of Network Security

    Science.gov (United States)

    Li, Angsheng; Hu, Qifu; Liu, Jun; Pan, Yicheng

    2016-01-01

    Recently, Li and Pan defined the metric of the K-dimensional structure entropy of a structured noisy dataset G to be the information that controls the formation of the K-dimensional structure of G that is evolved by the rules, order and laws of G, excluding the random variations that occur in G. Here, we propose the notion of resistance of networks based on the one- and two-dimensional structural information of graphs. Given a graph G, we define the resistance of G, written , as the greatest overall number of bits required to determine the code of the module that is accessible via random walks with stationary distribution in G, from which the random walks cannot escape. We show that the resistance of networks follows the resistance law of networks, that is, for a network G, the resistance of G is , where and are the one- and two-dimensional structure entropies of G, respectively. Based on the resistance law, we define the security index of a network G to be the normalised resistance of G, that is, . We show that the resistance and security index are both well-defined measures for the security of the networks. PMID:27255783

  7. Resistance and Security Index of Networks: Structural Information Perspective of Network Security.

    Science.gov (United States)

    Li, Angsheng; Hu, Qifu; Liu, Jun; Pan, Yicheng

    2016-06-03

    Recently, Li and Pan defined the metric of the K-dimensional structure entropy of a structured noisy dataset G to be the information that controls the formation of the K-dimensional structure of G that is evolved by the rules, order and laws of G, excluding the random variations that occur in G. Here, we propose the notion of resistance of networks based on the one- and two-dimensional structural information of graphs. Given a graph G, we define the resistance of G, written , as the greatest overall number of bits required to determine the code of the module that is accessible via random walks with stationary distribution in G, from which the random walks cannot escape. We show that the resistance of networks follows the resistance law of networks, that is, for a network G, the resistance of G is , where and are the one- and two-dimensional structure entropies of G, respectively. Based on the resistance law, we define the security index of a network G to be the normalised resistance of G, that is, . We show that the resistance and security index are both well-defined measures for the security of the networks.

  8. Resistance and Security Index of Networks: Structural Information Perspective of Network Security

    Science.gov (United States)

    Li, Angsheng; Hu, Qifu; Liu, Jun; Pan, Yicheng

    2016-06-01

    Recently, Li and Pan defined the metric of the K-dimensional structure entropy of a structured noisy dataset G to be the information that controls the formation of the K-dimensional structure of G that is evolved by the rules, order and laws of G, excluding the random variations that occur in G. Here, we propose the notion of resistance of networks based on the one- and two-dimensional structural information of graphs. Given a graph G, we define the resistance of G, written , as the greatest overall number of bits required to determine the code of the module that is accessible via random walks with stationary distribution in G, from which the random walks cannot escape. We show that the resistance of networks follows the resistance law of networks, that is, for a network G, the resistance of G is , where and are the one- and two-dimensional structure entropies of G, respectively. Based on the resistance law, we define the security index of a network G to be the normalised resistance of G, that is, . We show that the resistance and security index are both well-defined measures for the security of the networks.

  9. RI management by personal computer

    International Nuclear Information System (INIS)

    Ono, Isamu; Hiyoshi, Katsunori; Ono, Kazuhiko; Morimitsu, Wataru

    1983-01-01

    For RI-handling facilities up to medium scale, it has been studied whether a personal computer is applicable to the practical management of radioisotopes. In the present system, the number of writing in mini floppy disks is 1280 articles per diskette, which is the sufficient capacity for a storage medium for one year in variety of books. The correction of radioactivity decay as well as various totalizations can be made easily, so that the state of RI storage and use for the whole RI-handling facility can be grasped. Further, by the improvement of the output formats, the transfer to the books as obligated to write is possible. From the above reason, a personal computer is practically applicable with the management system and also leads to labor saving in RI management personnel. (Mori, K.)

  10. Development of a New BRDF-Resistant Vegetation Index for Improving the Estimation of Leaf Area Index

    Directory of Open Access Journals (Sweden)

    Su Zhang

    2016-11-01

    Full Text Available The leaf area index (LAI is one of the most important Earth surface parameters used in the modeling of ecosystems and their interaction with climate. Numerous vegetation indices have been developed to estimate the LAI. However, because of the effects of the bi-directional reflectance distribution function (BRDF, most of these vegetation indices are also sensitive to the effect of BRDF. In this study, we aim to present a new BRDF-resistant vegetation index (BRVI, which is sensitive to the LAI but insensitive to the effect of BRDF. Firstly, the BRDF effects of different bands were investigated using both simulated data and in-situ measurements of winter wheat made at different growth stages. We found bi-directional shape similarity in the solar principal plane between the green and the near-infrared (NIR bands and between the blue and red bands for farmland soil conditions and with medium chlorophyll content level. Secondly, the consistency of the shape of the BRDF across different bands was employed to develop a new BRDF-resistant vegetation index for estimating the LAI. The reflectance ratios of the NIR band to the green band and the blue band to the red band were reasonably assumed to be resistant to the BRDF effects. Nevertheless, the variation amplitude of the bi-directional reflectance in the solar principal plane was different for different bands. The divisors in the two reflectance ratios were improved by combining the reflectances at the red and green bands. The new BRVI was defined as a normalized combination of the two improved reflectance ratios. Finally, the potential of the proposed BRVI for estimation of the LAI was evaluated using both simulated data and in-situ measurements and also compared to other popular vegetation indices. The results showed that the influence of the BRDF on the BRVI was the weakest and that the BRVI retrieved LAI values well, with a coefficient of determination (R2 of 0.84 and an RMSE of 0.83 for the field

  11. [Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review].

    Science.gov (United States)

    Andrade, Maria Izabel Siqueira de; Oliveira, Juliana Souza; Leal, Vanessa Sá; Lima, Niedja Maria da Silva; Costa, Emília Chagas; Aquino, Nathalia Barbosa de; Lira, Pedro Israel Cabral de

    2016-06-01

    To identify cutoff points of the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index established for adolescents and discuss their applicability for the diagnosis of insulin resistance in Brazilian adolescents. A systematic review was performed in the PubMed, Lilacs and SciELO databases, using the following descriptors: "Adolescents", "insulin resistance" and "ROC curve". Original articles carried out with adolescents published between 2005 and 2015 in Portuguese, English or Spanish languages, which included the statistical analysis using ROC curve to determine the index cutoff (HOMA-IR) were included. A total of 184 articles were identified and after the study phases were applied, seven articles were selected for the review. All selected studies established their cutoffs using a ROC curve, with the lowest observed cutoff of 1.65 for girls and 1.95 for boys and the highest of 3.82 for girls and 5.22 for boys. Of the studies analyzed, one proposed external validity, recommending the use of the HOMA-IR cutoff >2.5 for both genders. The HOMA-IR index constitutes a reliable method for the detection of insulin resistance in adolescents, as long as it uses cutoffs that are more adequate for the reality of the study population, allowing early diagnosis of insulin resistance and enabling multidisciplinary interventions aiming at health promotion of this population. Copyright © 2015 Sociedade de Pediatria de São Paulo. Publicado por Elsevier Editora Ltda. All rights reserved.

  12. Application of DOI index to analysis of selected examples of resistivity imaging models in Quaternary sediments

    Directory of Open Access Journals (Sweden)

    Glazer Michał

    2014-12-01

    Full Text Available Interpretation of resistivity cross sections may be in many cases unreliable due to the presence of artifacts left by the inversion process. One way to avoid erroneous conclusions about geological structure is creation of Depth of Investigation (DOI index maps, which describe durability of prepared model with respect to variable parameters of inversion. To assess the usefulness of this interpretation methodology in resistivity imaging method over quaternary sediments, it has been used to one synthetic data set and three investigation sites. Two of the study areas were placed in the Upper Silesian Industrial District region: Bytom - Karb, Chorzów - Chorzow Stary; and one in the Southern Pomeranian Lake District across Piława River Valley. Basing on the available geological information the results show high utility of DOI index in analysis of received resistivity models, on which areas poorly constrained by data has been designated.

  13. Relationship of visfatin level to pancreatic endocrine hormone level, HOMA-IR index, and HOMA β-cell index in overweight women who performed hydraulic resistance exercise

    OpenAIRE

    Ha, Chang Ho; Swearingin, Brenda; Jeon, Yong Kyun

    2015-01-01

    [Purpose] This study aimed to examine the correlation of visfatin level to pancreatic endocrine hormone level, homeostasis model assessment of insulin resistance (HOMA-IR) index, and HOMA β-cell index in hydraulic resistance exercise. Furthermore, it investigated the relationship between visfatin level and other variables affected by exercise in overweight women. [Subjects and Methods] The exercise group trained for 12 weeks, 70 minutes/day, 5 days/week. Visfatin level, pancreatic endocrine h...

  14. Comparative study on resistant starch, amilose content and glycaemic index after precooked process in white rice

    Science.gov (United States)

    Pratiwi, V. N.

    2018-03-01

    Rice is a staple food and regarded as a useful carbohydrate source. In general rice is high in glycaemic index (GI) and low colonic fermentation. People are aware of the alterations in blood glucose levels or glycaemic index after consuming rice. Resistant starch (RS) and amylose content play an important role in controlling GI. GI and RS content have been established as important indicators of starch digestibility. The aim of this study was to determine the precooked process with hydrothermal (boiling at 80°C, 10 minutes) and cooling process with low temperature (4°C, 1 h) to increase potential content of RS and decrease of glycaemic index of white rice. There were two stages of this research, 1) preparation of white rice with precooked process; 2) analysis of precooked white rice characteristics (resistant starch, amylose content, and estimated glycaemic index). The result of analysis on precooked white rice showed an increased RS content (1.11%) and white rice (0.99%), but the difference was not statistically significant. The amylose content increased significantly after precooked process in white rice (24.70%) compared with white rice (20.89%). Estimated glycaemic index (EGI) decreased after precooked proses (65.63%) but not significant as compared to white rice (66.47%). From the present study it was concluded that precooked process had no significant impact on increasing RS and decreasing EGI of white rice. This may be due to the relatively short cooling time (1hour) in 4°C.

  15. Ductile Tearing Resistance Indexing of Automotive Grade DP 590 Steel Sheets: EWF Testing Using DENT Specimens

    Science.gov (United States)

    Sahoo, Subhadra; Padmapriya, N.; De, Partha Sarathi; Chakraborti, P. C.; Ray, S. K.

    2018-03-01

    The essential work of fracture (EWF) method has been explored for indexing the ductile tearing resistance of DP 590 automotive grade dual-phase steel sheet both in longitudinal (L-T) and transverse (T-L) orientations. The simplest possible test and analysis procedures have been adopted. The EWF method is found to be eminently suitable for routine quality control and product development purposes for such materials. Areas for further research for improving the experimental strategy are highlighted. For the investigated steel sheet, the estimated tearing resistance is found to be distinctly higher for the L-T orientation compared to the T-L orientation; the reason thereof merits further investigation.

  16. RIKEN RI Beam Factory project

    Energy Technology Data Exchange (ETDEWEB)

    Yano, Yasushige; Goto, Akira; Katayama, Takeshi [Institute of Physical and Chemical Research, Wako, Saitama (Japan)

    1997-03-01

    The RARF proposes `RIKEN RI Beam Factory` as a next facility-expanding project. The factory makes it the primary aim to provide RI (Radioactive Isotope) beams covering over the whole atomic-mass range with the world-highest intensity in a wide energy range up to several hundreds MeV/nucleon. These RI beams are generated by the fragmentation of high-intensity heavy-ion beams. For the efficient production heavy-ion energies will be boosted up to over 100 MeV/nucleon even for very heavy ions by a K2500-MeV superconducting ring cyclotron serving as a post accelerator of the existing K540-MeV ring cyclotron. A new type of experimental installation called `MUSES` (Multi-USe Experimental Storage rings) will be constructed as well. With MUSES, various types of unique colliding experiments will become possible. (author)

  17. Lipid accumulation product and triglycerides/glucose index are useful predictors of insulin resistance.

    Science.gov (United States)

    Mazidi, Mohsen; Kengne, Andre-Pascal; Katsiki, Niki; Mikhailidis, Dimitri P; Banach, Maciej

    2018-03-01

    To investigate the association of triglycerides/glucose index (TyG index), anthropometrically predicted visceral adipose tissue (apVAT), lipid accumulation product (LAP), visceral adiposity index (VAI) and triglycerides (TG):high density lipoprotein-cholesterol (HDL-C) ratio with insulin resistance (IR) in adult Americans. This study was based on data from three NHANES cycles (2005 to 2010). The TyG index was calculated as ln [TG×fasting glucose/2]. VAI was calculated using gender-specific formulas: men [waist circumference (WC)/39.68+(1.88×body mass index (BMI)]×(TG/1.03)×(1.31/HDL-C); women: [WC/36.58+(1.89×BMI)]×(TG/0.81)×(1.52/HDL-C). LAP index was calculated as [WC-65]×[TG] in men, and [WC-58]×[TG] in women. Correlation and regression analyses accounted for the complex sampling of database. A total of 18,318 subjects was included in this analysis [mean age 47.6Years]; 48.7% (n=8918) men]. The homeostatic model assessment of insulin resistance (HOMA-IR) had a significant positive correlation with the TyG index (r=0.502), LAP (r=0.551), apVAT (r=0.454), TG:HDL-C ratio (r=0.441) and VAI (r=451) (pindex is a simple, cheap and accurate although not perfect, surrogate marker of HOMA-diagnosed IR among adult Americans. Moreover, it has higher predictability than other screening tools which traditionally applied. Among the markers, apVAT had the highest specificity and the TG:HDL-C ratio had the highest sensitivity. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Influence of the measurement location on the resistance index in the umbilical arteries: a hemodynamic approach.

    Science.gov (United States)

    Vieyres, P; Durand, A; Patat, F; Descamps, P; Gregoire, J M; Pourcelot, D; Pourcelot, L

    1991-12-01

    A computer model was used to study the primary factors generating the reduction in resistance index, (S-D)/S, values observed by ultrasonic Doppler measurements in the umbilical artery, from the fetal insertion to the placental insertion (S represents the amplitude of the systolic peak and D the amplitude of the diastolic peak). This hemodynamic approach shows that the placental resistance is the primary factor, the viscosity and the cord length playing secondary roles. Clinically, the position of the measurement along the cord is an important factor. To increase the sensitivity of the index, the Doppler measurement must be performed near the fetal insertion, whereas a measurement near the placental insertion will make the Doppler examination more specific.

  19. The relationship of insulin resistance estimated by triglyceride glucose index and coronary plaque characteristics.

    Science.gov (United States)

    Won, Ki-Bum; Kim, Yun Seok; Lee, Byoung Kwon; Heo, Ran; Han, Donghee; Lee, Ji Hyun; Lee, Sang-Eun; Sung, Ji Min; Cho, Iksung; Park, Hyung-Bok; Cho, In-Jeong; Chang, Hyuk-Jae

    2018-05-01

    The triglyceride glucose (TyG) index is a useful surrogate marker for insulin resistance, which is an important risk factor for coronary artery disease (CAD). However, data on the relationship of the TyG index and coronary plaque characteristics are limited.This study included 2840 participants with near-normal renal function who underwent coronary computed tomography angiography. CAD was defined as the presence of any plaques, and obstructive CAD was defined as the presence of plaques with ≥50% stenosis. The relationship between the TyG index and noncalcified plaque (NCP), calcified or mixed plaque (CMP), and coronary artery calcium score (CACS) was evaluated.All participants were stratified into 4 groups based on the quartiles of the TyG index. The prevalence of CAD and obstructive CAD significantly increased with increasing quartiles. The risk for NCP and obstructive NCP was not different among all groups. However, compared with group I (lowest quartile), the risk for CMP was higher in groups III (odds ratio [OR]: 1.438) and IV (highest quartile) (OR: 1.895) (P index was associated with an increased risk for CAD (OR: 1.700), obstructive CAD (OR: 1.692), and CACS >400 (OR: 1.448) (P index was independently associated with the presence and severity of CAD due to an increased risk for CMP.

  20. The triglyceride and glucose index is useful for recognising insulin resistance in children.

    Science.gov (United States)

    Rodríguez-Morán, M; Simental-Mendía, L E; Guerrero-Romero, F

    2017-06-01

    Although recognising insulin resistance (IR) in children is particularly important, the gold standard test used to diagnose it, the euglyceamic glucose clamp, is costly, invasive and is not routinely available in our clinical settings in Mexico. This study evaluated whether the triglyceride-glucose (TyG) index would provide a useful alternative. A total of 2779 school children aged seven to 17 years, from Durango, Mexico, were enrolled during 2015-2016. The gold standard euglyceamic-hyperinsulinemic clamp test was performed in a randomly selected subsample of 125 children, and diagnostic concordance between the TyG index and the homoeostasis model assessment of IR was evaluated in all of the 2779 enrolled children. The best cut-off values for recognising IR using the TyG index were 4.65 for prepubertal girls and boys, 4.75 for pubertal girls and 4.70 for pubertal boys. Concordance between the TyG index and the homoeostasis model assessment of IR was 0.910 and 0.902 for the prepubertal girls and boys, 0.932 for the pubertal girls and 0.925 for the pubertal boys. The TyG index was useful for recognising IR in both prepubertal and pubertal children and could provide a feasible alternative to the costly and invasive gold standard test for IR in resource-limited settings. ©2017 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  1. Body composition using deuterated water, index of insulin resistance and cortisol levels in Costa Rican school in the metropolitan area

    International Nuclear Information System (INIS)

    Valverde Vindas, Allan Ignacio

    2014-01-01

    Body composition in the Costa Rican child population is evaluated and analyzed to determine the relationship with the index of insulin resistance and serum cortisol levels. 113 children in the metropolitan area were studied using deuterium isotope techniques as reference method for overweight and obesity. Morning cortisol levels were determined by immunoassay techniques (ELISA). The insulin resistance index of 113 Costa Rican boys and girls is obtained by the homeostatic method and the relationship between body composition with index of insulin resistance or levels of cortisol [es

  2. Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance

    International Nuclear Information System (INIS)

    Gutiérrez-Barrios, Alejandro; Camacho-Jurado, Francisco; Díaz-Retamino, Enrique; Gamaza-Chulián, Sergio; Agarrado-Luna, Antonio; Oneto-Otero, Jesús; Del Rio-Lechuga, Ana; Benezet-Mazuecos, Javier

    2015-01-01

    Summary: We present a review of microvascular dysfunction in hypertrophic cardiomyopathy (HCM) and an interesting case of a symptomatic familial HCM patient with inducible ischemia by single photon emission computed tomography. Coronary angiography revealed normal epicardial arteries. Pressure wire measurements of fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microvascular resistance (IMR) demonstrated a significant microcirculatory dysfunction. This is the first such case that documents this abnormality invasively using the IMR. The measurement of IMR, a novel marker of microcirculatory dysfunction, provides novel insights into the pathophysiology of this condition. - Highlights: • Microvascular dysfunction is a common feature in hypertrophic cardiomyopathy (HCM) and represents a strong predictor of unfavorable outcome and cardiovascular mortality. • The index of microvascular resistance (IMR) is a new method for invasively assessing the state of the coronary microcirculation using a single pressure-temperature sensor-tipped coronary wire. • However assessment of IMR in HCM has not been previously reported. We report a case in which microvascular dysfunction is assessed by IMR. This index may be useful in future researches of HCM.

  3. Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance

    Energy Technology Data Exchange (ETDEWEB)

    Gutiérrez-Barrios, Alejandro, E-mail: aleklos@hotmail.com [Cardiology Department, Jerez Hospital, Jerez (Spain); Camacho-Jurado, Francisco [Cardiology Department, Punta Europa Hospital, Algeciras (Spain); Díaz-Retamino, Enrique; Gamaza-Chulián, Sergio; Agarrado-Luna, Antonio; Oneto-Otero, Jesús; Del Rio-Lechuga, Ana; Benezet-Mazuecos, Javier [Cardiology Department, Jerez Hospital, Jerez (Spain)

    2015-10-15

    Summary: We present a review of microvascular dysfunction in hypertrophic cardiomyopathy (HCM) and an interesting case of a symptomatic familial HCM patient with inducible ischemia by single photon emission computed tomography. Coronary angiography revealed normal epicardial arteries. Pressure wire measurements of fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microvascular resistance (IMR) demonstrated a significant microcirculatory dysfunction. This is the first such case that documents this abnormality invasively using the IMR. The measurement of IMR, a novel marker of microcirculatory dysfunction, provides novel insights into the pathophysiology of this condition. - Highlights: • Microvascular dysfunction is a common feature in hypertrophic cardiomyopathy (HCM) and represents a strong predictor of unfavorable outcome and cardiovascular mortality. • The index of microvascular resistance (IMR) is a new method for invasively assessing the state of the coronary microcirculation using a single pressure-temperature sensor-tipped coronary wire. • However assessment of IMR in HCM has not been previously reported. We report a case in which microvascular dysfunction is assessed by IMR. This index may be useful in future researches of HCM.

  4. Childhood craniopharyngioma: greater hypothalamic involvement before surgery is associated with higher homeostasis model insulin resistance index

    Science.gov (United States)

    Trivin, Christine; Busiah, Kanetee; Mahlaoui, Nizar; Recasens, Christophe; Souberbielle, Jean-Claude; Zerah, Michel; Sainte-Rose, Christian; Brauner, Raja

    2009-01-01

    Background Obesity seems to be linked to the hypothalamic involvement in craniopharyngioma. We evaluated the pre-surgery relationship between the degree of this involvement on magnetic resonance imaging and insulin resistance, as evaluated by the homeostasis model insulin resistance index (HOMA). As insulin-like growth factor 1, leptin, soluble leptin receptor (sOB-R) and ghrelin may also be involved, we compared their plasma concentrations and their link to weight change. Methods 27 children with craniopharyngioma were classified as either grade 0 (n = 7, no hypothalamic involvement), grade 1 (n = 8, compression without involvement), or grade 2 (n = 12, severe involvement). Results Despite having similar body mass indexes (BMI), the grade 2 patients had higher glucose, insulin and HOMA before surgery than the grade 0 (P = 0.02, craniopharyngioma before surgery seems to determine the degree of insulin resistance, regardless of the BMI. The pre-surgery HOMA values were correlated with the post-surgery weight gain. This suggests that obesity should be prevented by reducing inn secretion in those cases with hypothalamic involvement. PMID:19341477

  5. Childhood craniopharyngioma: greater hypothalamic involvement before surgery is associated with higher homeostasis model insulin resistance index

    Directory of Open Access Journals (Sweden)

    Sainte-Rose Christian

    2009-04-01

    Full Text Available Abstract Background Obesity seems to be linked to the hypothalamic involvement in craniopharyngioma. We evaluated the pre-surgery relationship between the degree of this involvement on magnetic resonance imaging and insulin resistance, as evaluated by the homeostasis model insulin resistance index (HOMA. As insulin-like growth factor 1, leptin, soluble leptin receptor (sOB-R and ghrelin may also be involved, we compared their plasma concentrations and their link to weight change. Methods 27 children with craniopharyngioma were classified as either grade 0 (n = 7, no hypothalamic involvement, grade 1 (n = 8, compression without involvement, or grade 2 (n = 12, severe involvement. Results Despite having similar body mass indexes (BMI, the grade 2 patients had higher glucose, insulin and HOMA before surgery than the grade 0 (P = 0.02, The data for the whole population before and 6–18 months after surgery showed increases in BMI (P Conclusion The hypothalamic involvement by the craniopharyngioma before surgery seems to determine the degree of insulin resistance, regardless of the BMI. The pre-surgery HOMA values were correlated with the post-surgery weight gain. This suggests that obesity should be prevented by reducing inn secretion in those cases with hypothalamic involvement.

  6. Fasting Ghrelin Levels Are Decreased in Obese Subjects and Are Significantly Related With Insulin Resistance and Body Mass Index

    Directory of Open Access Journals (Sweden)

    Dimitrios Papandreou

    2017-10-01

    CONCLUSION: Obese subjects have low fasting ghrelin levels that they are significantly related to insulin resistance and body mass index. More prospective studies are needed to establish the role of ghrelin in the pathogenesis of human obesity.

  7. Study of Insulin Resistance in Patients With β Thalassemia Major and Validity of Triglyceride Glucose (TYG) Index.

    Science.gov (United States)

    Ansari, Arif M; Bhat, Kamalakshi G; Dsa, Smitha S; Mahalingam, Soundarya; Joseph, Nitin

    2018-03-01

    Complications like impaired glucose tolerance and diabetes mellitus due to iron overload need early identification in thalassemia. We studied the proportion of insulin resistance in thalassemia major patients on chronic transfusion, identified insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride glucose (TYG) index, compared them and validated TYG index. In total, 73 thalassemia patients on regular transfusion for 3 years with serum ferritin >1500 ng/mL were studied. Serum ferritin, fasting blood glucose, triglycerides, and insulin levels were measured, HOMA-IR, and TYG index calculated and analyzed. Mean fasting glucose, triglyceride, and serum insulin values were 104 mg/dL, 164.18 mg/dL, and 19.6 m IU/mL, respectively. Mean serum ferritin was 5156 ng/mL. Insulin resistance was prevalent in one third of thalassemia patients and showed increase with age and serum ferritin. Insulin resistance by HOMA-IR was 32% as against 16% by TYG index with a cut-off value of 4.3. Using receiver operating charecteristic curve analysis, it was found that, by lowering the value of TYG index to 4.0215, sensitivity improved to 78.3% (from 39.13%) with specificity of 70%. Hence, we recommend a newer lower cut-off value of 4.0215 for TYG index for better sensitivity and specificity in identifying insulin resistance.

  8. Indexed

    CERN Document Server

    Hagy, Jessica

    2008-01-01

    Jessica Hagy is a different kind of thinker. She has an astonishing talent for visualizing relationships, capturing in pictures what is difficult for most of us to express in words. At indexed.blogspot.com, she posts charts, graphs, and Venn diagrams drawn on index cards that reveal in a simple and intuitive way the large and small truths of modern life. Praised throughout the blogosphere as “brilliant,” “incredibly creative,” and “comic genius,” Jessica turns her incisive, deadpan sense of humor on everything from office politics to relationships to religion. With new material along with some of Jessica’s greatest hits, this utterly unique book will thrill readers who demand humor that makes them both laugh and think.

  9. Fasting Triglycerides and Glucose Index as a Diagnostic Test for Insulin Resistance in Young Adults.

    Science.gov (United States)

    Guerrero-Romero, Fernando; Villalobos-Molina, Rafael; Jiménez-Flores, J Rafael; Simental-Mendia, Luis E; Méndez-Cruz, René; Murguía-Romero, Miguel; Rodríguez-Morán, Martha

    2016-07-01

    Although the Glucose and Triglyceride levels (TyG) index is useful for identification of insulin resistance (IR) in different ethnic groups, it has not been evaluated in young adults. We undertook this study to evaluate the TyG index as a diagnostic test for IR in young adults. A total of 5,538 healthy young adults, 3,795 (68.5%) non-pregnant women and 1,743 (31.5%) men, with an average age of 19.2 ± 1.4 years, were enrolled in a population-based cross-sectional study. To estimate diagnostic characteristics of the TyG index, a randomized subsample of the target population (n = 75) was under euglycemic-hyperinsulinemic clamp test. Using the cutoff values obtained in the clamp study, the diagnostic concordance between TyG index and HOMA-IR was evaluated in the overall population. The TyG index was calculated as the Ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2. Normal weight, overweight, and obesity were identified in 3,632 (65.6%), 1,355 (24.5%), and 551 (9.9%) participants. A total of 346 (9.1%) men and 278 (15.9%) women exhibited IR. The best cutoff value of TyG index for diagnosis of IR was 4.55 (sensitivity 0.687, negative predictive value (NPV) 0.844, and negative likelihood ratio (NLR) 0.47) for women and 4.68 (sensitivity 0.673, NPV 0.900, and NLR 0.45) for men. In normal-weight individuals the diagnostic concordance between TyG index and HOMA-IR was 0.934 and 0.915, in the overweight subjects was 0.908 and 0.895 and, in the obese participants 0.916 and 0.950, for men and women, respectively. TyG index may be useful for screening IR in young adults. Copyright © 2016 IMSS. Published by Elsevier Inc. All rights reserved.

  10. NEW METABOLIC INDEX USE POTENTIALITIES IN EVALUATION OF INSULIN RESISTANCE IN CLINICAL PRACTICE

    Directory of Open Access Journals (Sweden)

    G. E. Roytberg

    2015-09-01

    Full Text Available Early diagnostics of insulin resistance (IR is one of the methods of primary prevention of cardio-vascular diseases and type 2 diabetes mellitus. The HOMA-IR index and ratio of plasma triglyceride to high-density lipoprotein cholesterol concentration are the most frequently used indices in clinical and epidemiological scientific research. Prognostic value and efficacy of these tests as a screening method are not high. What method of IR detection should be used in clinical practice and how to interpret received values of the indices is still a matter of dispute.Aim. To evaluate informative value, sensitivity and specificity of a new metabolic index (MI for IR estimation in comparison with the calculated HOMA-IR index.Material and methods. A total of 845 patients (298 men, 547 women were enrolled into the further study after an outpatient regular medical check-up of 2,615 persons. Mean age of the patients was 45.77±12.18 years, body mass index – 28.95±1.44 kg/m2. To evaluate lipid and carbohydrate metabolism blood chemistry parameters were assessed. IR was determined by the Homeostasis Model Assessment (HOMA-IR and an oblique calculated index based on lipid metabolism parameters. In accordance with the developed screening method of IR detection (invention patent № 2493566 MI considering carbohydrate and lipid changes was proposed.Results. Calculation of MI and its threshold level was performed by analysis of a characteristic curve. Graphical dependence between sensitivity and specificity of the proposed index was demonstrated: sensitivity of the test was 75.7%, specificity – 89.1%. Probability of IR at MI value >7.0 was 63.5% (positive predictive value, probability of IR absence at the index value ≤7.0 was 93.6% (negative predictive value. The general accuracy of the test, which is characterized by the area under the characteristic curve, was 0.881 with 95%-confidence interval within 0.854-0.905.Conclusion. The importance of negative

  11. NEW METABOLIC INDEX USE POTENTIALITIES IN EVALUATION OF INSULIN RESISTANCE IN CLINICAL PRACTICE

    Directory of Open Access Journals (Sweden)

    G. E. Roytberg

    2014-01-01

    Full Text Available Early diagnostics of insulin resistance (IR is one of the methods of primary prevention of cardio-vascular diseases and type 2 diabetes mellitus. The HOMA-IR index and ratio of plasma triglyceride to high-density lipoprotein cholesterol concentration are the most frequently used indices in clinical and epidemiological scientific research. Prognostic value and efficacy of these tests as a screening method are not high. What method of IR detection should be used in clinical practice and how to interpret received values of the indices is still a matter of dispute.Aim. To evaluate informative value, sensitivity and specificity of a new metabolic index (MI for IR estimation in comparison with the calculated HOMA-IR index.Material and methods. A total of 845 patients (298 men, 547 women were enrolled into the further study after an outpatient regular medical check-up of 2,615 persons. Mean age of the patients was 45.77±12.18 years, body mass index – 28.95±1.44 kg/m2. To evaluate lipid and carbohydrate metabolism blood chemistry parameters were assessed. IR was determined by the Homeostasis Model Assessment (HOMA-IR and an oblique calculated index based on lipid metabolism parameters. In accordance with the developed screening method of IR detection (invention patent № 2493566 MI considering carbohydrate and lipid changes was proposed.Results. Calculation of MI and its threshold level was performed by analysis of a characteristic curve. Graphical dependence between sensitivity and specificity of the proposed index was demonstrated: sensitivity of the test was 75.7%, specificity – 89.1%. Probability of IR at MI value >7.0 was 63.5% (positive predictive value, probability of IR absence at the index value ≤7.0 was 93.6% (negative predictive value. The general accuracy of the test, which is characterized by the area under the characteristic curve, was 0.881 with 95%-confidence interval within 0.854-0.905.Conclusion. The importance of negative

  12. The triglyceride-glucose index, an insulin resistance marker in newborns?

    Science.gov (United States)

    Gesteiro, Eva; Bastida, Sara; Barrios, Laura; Sánchez-Muniz, Francisco J

    2018-04-01

    The study aims to assess the utility of the triglyceride-glucose index (TyG) as a marker of insulin resistance (IR) in neonates. TyG and the homeostatic model assessment (HOMA-IR) values were compared in 196 singleton, term normoweight and without distress newborns. A Decision Tree procedure (CHAID) was used to classify cases into groups or predict values of a dependent (Ln HOMA-IR) variable. Three nodes were drawn for TyG: ≤ 6.7, > 6.7-7.8 and > 7.8 (p glucose challenge test (p = 0.138) classifications nor by the TyG node* glucose challenge test and TyG node*gender interactions (p = 0.456 and p = 0.209, respectively). Glucose, HOMA-IR, and the triglyceride/HDL cholesterol ratio increased progressively from node 1 to 3 for TyG while QUICKI decreased. In conclusion, TyG appears to be a suitable tool for identifying IR at birth, justifying the further insulin determination in those neonates. TyG ≥ 7.8 is recommended as cut-off point in neonates. The need for a follow-up study to confirm the TyG as early IR marker is desirable. • HOMA-IR and the triglyceride-glucose index (TyG) show a high correlation. • The TyG has been used as an insulin resistance marker in adults. • This is the first study where TyG has been assessed in neonates. • TyG appears to be a suitable and cheap tool for identifying insulin resistance at birth.

  13. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index.

    Science.gov (United States)

    Irace, C; Carallo, C; Scavelli, F B; De Franceschi, M S; Esposito, T; Tripolino, C; Gnasso, A

    2013-07-01

    The present investigation was designed to test the association between carotid atherosclerosis and two simple markers of insulin resistance, i.e. HOMA-Index and TyG-Index. The study was performed in two different cohorts. In the first cohort, 330 individuals were enrolled. Blood pressure, lipids, glucose, waist and cigarette smoking were evaluated. HOMA-IR and TyG-Index were calculated as markers of prevalent hepatic and muscular insulin resistance respectively. Carotid atherosclerosis was assessed by Doppler ultrasonography. The association between cardiovascular risk factors, markers of insulin resistance and carotid atherosclerosis was assessed by multiple logistic regression analyses. In the second cohort, limited to the evaluation of TyG-Index, 1432 subjects were studied. In the first cohort, TyG-Index was significantly associated with carotid atherosclerosis in a model including age, sex, diabetes, cigarette smoking and LDL cholesterol, while HOMA-IR was not. When components of metabolic syndrome were added to the model as dichotomous variables (absent/present), TyG-Index retained its predictive power. The same result was obtained when the metabolic syndrome was added to the model (absence/presence). The association between TyG-Index and carotid atherosclerosis was confirmed in the second cohort. The present findings suggest that TyG-Index is better associated with carotid atherosclerosis than HOMA-IR. © 2013 John Wiley & Sons Ltd.

  14. Novel adiponectin-resistin (AR and insulin resistance (IRAR indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and metabolic syndrome: a case control study

    Directory of Open Access Journals (Sweden)

    Muniandy Sekaran

    2011-01-01

    Full Text Available Abstract Background Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis. Meta-analyses showed that hypoadiponectinemia and hyperresistinemia are strongly associated with increased risk of insulin resistance, type 2 diabetes (T2DM, metabolic syndrome (MS and cardiovascular disease. The aim of this study was to propose a novel adiponectin-resistin (AR index by taking into account both adiponectin and resistin levels to povide a better indicator of the metabolic homeostasis and metabolic disorders. In addition, a novel insulin resistance (IRAR index was proposed by integration of the AR index into an existing insulin resistance index to provide an improved diagnostic biomarker of insulin sensitivity. Methods In this case control study, anthropometric clinical and metabolic parameters including fasting serum total adiponectin and resistin levels were determined in 809 Malaysian men (208 controls, 174 MS without T2DM, 171 T2DM without MS, 256 T2DM with MS whose ages ranged between 40-70 years old. Significant differences in continuous variables among subject groups were confirmed by ANCOVA or MANCOVA test using 1,000 stratified bootstrap samples with bias corrected and accelerated (BCa 95% CI. Spearman's rho rank correlation test was used to test the correlation between two variables. Results The AR index was formulated as 1+log10(R0-log10(A0. The AR index was more strongly associated with increased risk of T2DM and MS than hypoadiponectinemia and hyperresistinemia alone. The AR index was more strongly correlated with the insulin resistance indexes and key metabolic endpoints of T2DM and MS than adiponectin and resistin levels alone. The AR index was also correlated with a higher number of MS components than adiponectin and resistin levels alone. The IRAR index was formulated as log10(I0G0+log10(I0G0log10(R0/A0. The normal reference range of the IRAR index for insulin sensitive individuals was

  15. ri Talveti luulevalimik hispaania keeles

    Index Scriptorium Estoniae

    2003-01-01

    Talvet, Jüri. Elegia Estonia y otros poemas : [luulevalimik] / tõlkinud Jüri Talvet ja Albert Lázaro Tinaut ; järelsõna Janika Kronberg. Valencia : Palmart Capitelum, 2002; Vt. ka Eesti Päevaleht, 13. jaan., lk. 16

  16. Genetic transformation of Begonia tuberhybrida by Ri rol genes.

    Science.gov (United States)

    Kiyokawa, S; Kikuchi, Y; Kamada, H; Harada, H

    1996-04-01

    We have developed an Agrobacterium -mediated transformation system for commercial Begonia species. The leaf explants of Begonia semperflorens, Begonia x hiemalis and B. tuberhybrida were inoculated with Agrobacterium tumefaciens LBA4404 harboring a binary vector pBI121 which contains rolA, B and C genes of an agropine type Ri plasmid (pRiA4b). Kanamycin resistant shoots of B. tuberhybrida were obtained on MS agar medium supplemented with 0.1 mg/l NAA, 0.5 mg/l BA, 500 mg/l claforan and 100 mg/l kanamycin. These shoots exhibited GUS activity and Southern analysis showed a single copy insertion into the genome. When the transgenic plants were transferred to soil, they displayed the phenotype specific to the transgenic plants by A. rhizogenes such as dwarfness, delay of flowering, and wrinkled leaves and petals.

  17. Clinical Significance of Inflammatory Markers in Polycystic Ovary Syndrome: Their Relationship to Insulin Resistance and Body Mass Index

    Directory of Open Access Journals (Sweden)

    Nervana Samy

    2009-01-01

    Full Text Available Background: Women with polycystic ovary syndrome (PCOS have an increased prevalence of insulin resistance (IR and related disorders. Elevated serum levels of high sensitivity CRP (hs-CRP, interleukin-6 (IL-6 and tumor necrosis factor α (TNF-α reflect low-grade chronic inflammation and have been associated with several insulin-resistant states; they are useful cardiovascular risk markers. The objective of this study was to investigate whether soluble inflammatory markers are altered in PCOS focusing on its relationship with obesity and indexes of insulin resistance.

  18. Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial

    DEFF Research Database (Denmark)

    Fuleihan G, EI-Haij; Baddoura, Rafic; Habib, Robert H

    2016-01-01

    BACKGROUND: It is unclear whether and at what dose vitamin D supplementation affects insulin resistance (IR). OBJECTIVE: We sought to investigate whether vitamin D at doses higher than currently recommended decreases indexes of IR in an ambulatory population of overweight elderly subjects. DESIGN...

  19. Biliary Cast Syndrome: Hepatic Artery Resistance Index, Pathological Changes, Morphology and Endoscopic Therapy

    Directory of Open Access Journals (Sweden)

    Hu Tian

    2015-01-01

    Full Text Available Background: Biliary cast syndrome (BCS was a postoperative complication of orthotopic liver transplantation (OLT, and the reason for BSC was considered to relate with ischemic type biliary lesions. This study aimed to evaluate the relationship between BCS following OLT and the hepatic artery resistance index (HARI, and to observe pathological changes and morphology of biliary casts. Methods: Totally, 18 patients were diagnosed with BCS by cholangiography following OLT using choledochoscope or endoscopic retrograde cholangiopancreatography. In addition, 36 patients who did not present with BCS in the corresponding period had detectable postoperative HARI on weeks 1, 2, 3 shown by color Doppler flow imaging. The compositions of biliary casts were analyzed by pathological examination and scanning electron microscopy. Results: HARI values of the BCS group were significantly decreased as compared with the non-BCS group on postoperative weeks 2 and 3 (P 1 (OR = 1.300; 1.223; and 1.889, respectively. The OR of HARI 3 was statistically significant (OR = 1.889; 95% confidence interval = 1.166-7.490; P = 0.024. The compositions of biliary casts were different when bile duct stones were present. Furthermore, vascular epithelial cells were found by pathological examination in biliary casts. Conclusions: HARI may possibly serve as an independent risk factor and early predictive factor of BCS. Components and formation of biliary casts and bile duct stones are different.

  20. [Strength, flexibility, balance, resistance and flexibility assessment according to body mass index in active older women].

    Science.gov (United States)

    Vaquero-Cristóbal, Raquel; Martínez González-Moro, Ignacio; Alacid Cárceles, Fernando; Ros Simón, Esperanza

    2013-01-01

    Overweight and obesity are increasing at an alarming rate among older people. This is mainly because this population is predominantly sedentary. The aim of this study was to classify, according to the body mass index (BMI), a group of older active women and to evaluate the different basic physical abilities as a function of this. The BMI and fitness were evaluated in 60 elderly active women (mean age: 66.14 ± 6.59 years) using the 2-minute step test, arm curl test, chair stand test, back scratch test, chair-sit and reach-test, flamenco test, and 8-foot up-and-go test. It was found that 52.23% of the women studied had a normal BMI and 47.76% were slightly overweight. There were no cases of obesity or underweight. Women with normal BMI had better values in all tests than overweight women. Significant differences were found in the flamenco test (P<.05), and 8-foot up-and-go test (P<.01). Older women who usually do physical activity had a normal or slightly overweight BMI. It was also found that women with lower BMI have better resistance, flexibility, balance and strength. Copyright © 2012 SEGG. Published by Elsevier Espana. All rights reserved.

  1. The Renal Arterial Resistance Index Predicts Worsening Renal Function in Chronic Heart Failure Patients

    Science.gov (United States)

    Iacoviello, Massimo; Monitillo, Francesco; Leone, Marta; Citarelli, Gaetano; Doronzo, Annalisa; Antoncecchi, Valeria; Puzzovivo, Agata; Rizzo, Caterina; Lattarulo, Maria Silvia; Massari, Francesco; Caldarola, Pasquale; Ciccone, Marco Matteo

    2016-01-01

    Background/Aim The renal arterial resistance index (RRI) is a Doppler measure, which reflects abnormalities in the renal blood flow. The aim of this study was to verify the value of RRI as a predictor of worsening renal function (WRF) in a group of chronic heart failure (CHF) outpatients. Methods We enrolled 266 patients in stable clinical conditions and on conventional therapy. Peak systolic velocity and end diastolic velocity of a segmental renal artery were obtained by pulsed Doppler flow, and RRI was calculated. Creatinine serum levels were evaluated at baseline and at 1 year, and the changes were used to assess WRF occurrence. Results During follow-up, 34 (13%) patients showed WRF. RRI was associated with WRF at univariate (OR: 1.13; 95% CI: 1.07–1.20) as well as at a forward stepwise multivariate logistic regression analysis (OR: 1.09; 95% CI: 1.03–1.16; p = 0.005) including the other univariate predictors. Conclusions Quantification of arterial renal perfusion provides a new parameter that independently predicts the WRF in CHF outpatients. Its possible role in current clinical practice to better define the risk of cardiorenal syndrome progression is strengthened. PMID:27994601

  2. [Effect of metabolic uncontrolled diabetes mellitus (DM) on the resistance index of renal (IR) Interlobar arteries assessed with pulsed Doppler].

    Science.gov (United States)

    Muraira-Cárdenas, Luis Cesar; Barrios-Pérez, Martín

    2016-01-01

    Diabetes mellitus is a chronic degenerative disease characterized by elevated hyperglycemia, triggering a series of processes and culminating in chronic, uncontrolled, cellular and vascular damage in different organs. To assess whether the elevated glycosylated hemoglobin, microalbuminuria, and the time evolution of more than 10 years of diabetes mellitus are associated with elevated resistance index of the interlobar renal arteries assessed with pulsed Doppler in patients with metabolic uncontrolled diabetes mellitus. Transversal-analytical, observational, prospective study that included diabetic patients attending UMAE abdominal ultrasound in 25 of IMSS, from October 15, 2014 to November 15, 2014, which was performed for pulsed Doppler index resistance of vascular interlobar renal arteries and was collected from electronic medical records: age, sex, glycated hemoglobin, and microalbuminuria. The association between metabolic uncontrolled diabetes mellitus was analyzed with the elevation of resistance index by χ(2) test or Fisher, being significant with a value of p diabetes were examined, with an average age of 52.3 ± 14.2 years, 41 were older than 50 years (65.0%), 26 with hypertension (41.2%), 32 with higher levels of glycated hemoglobin 7 (50.8%), 35 with normoalbuminuria (55.6%), 28 with microalbuminuria (44.4%), and 39 with a time evolution of diabetes of more than 10 years (61.9%). We observed a statistically significant difference between microalbuminuria and increased duration of diabetes mellitus with high resistance index. The alterations in renal microvasculature conditioned by the occurrence of microalbuminuria in diabetic nephropathy and the duration of diabetes are strongly associated with higher resistance index.

  3. Presence of pRI1:

    DEFF Research Database (Denmark)

    Migura, Lourdes Garcia; Hasman, Henrik; Jensen, Lars Bogø

    2009-01-01

    This study focused on the molecular characterization of a small cryptic, mobilizable plasmid (6038 bp) sequenced from an E. faecium 9631160-1 of poultry origin. Sequence analysis of pRI1 revealed seven open reading frames. pRI1 contained an IS 100% identical to ISEfa4. This insertion element...... almost identical to the repA from the pEFNP1 and pKQ10 plasmids from E. faecium was also identified. Presence of the pRI1 replication initiation gene (rep) was analyzed in a panel of 159 E. faecium isolates of human and animal origin from different European countries, of which 60 tested positive...

  4. Domik Petra / Jüri Kuuskemaa

    Index Scriptorium Estoniae

    Kuuskemaa, Jüri, 1942-

    2006-01-01

    Kunstiajaloolane Jüri Kuuskemaa tutvustab Peeter I majamuuseumi Kadriorus. Maja ajaloost, sisustusest (mööbel, kunstiesemed). Keldriruumis eksponeeritud Salomon Zeltrechti ja tema abiliste poolt tehtud kivibüstidest

  5. [Söejoonistused] / Jüri Marran

    Index Scriptorium Estoniae

    Marran, Jüri, 1937-

    2005-01-01

    ri Marran on hariduselt füüsik ja kunstihariduse omandanud Melanie ja Erich Arraku ateljeekoolis. Lk. 1391 (Gravitatsioon), 1440 (Valgus), 1471 (Vastastikmõju), 1486 (Massenergia), 1519 (Valguse dualism), 1555 (Aja dilatatsioon)

  6. Effect of 8 Weeks Resistance Training on Some Antioxidant/Oxidative Indexes in Postmenopausal Women with Breast Cancer

    Directory of Open Access Journals (Sweden)

    F. Fathollahi Shoorabeh

    2017-04-01

    Full Text Available Aims: Breast cancer is the most common cancer among women that usually begins with abnormal growth and division of different breast cells. There is some evidence that there is an inverse relationship between levels of antioxidants and the risk of breast cancer. The purpose of this study was to investigate the effect of 8 weeks resistance training on some antioxidant/oxidative indexes in postmenopausal women with breast cancer. Materials & Methods: In this semi-experimental study, in 2014, 30 postmenopausal women with breast cancer in Khorramabad city were selected by available sampling method and randomly divided into 2 groups: experimental group (n=16 and control group (n=14. The experimental group performed resistance training for 8 weeks, which started from 30% 1RM (one repetition maximum and reached 45-50% 1RM at the end of the eighth week. Blood samples were taken from subjects for the measurement of superoxide dismutase (SOD, glutathione peroxidase (GPX and malondialdehyde (MDA serum levels, 48 hours before and after the training protocol. Data were analyzed by SPSS 19 software using independent t-test and dependent t-test. Findings: After performing 8 weeks of resistance training, serum levels of SOD and GPX significantly increased and MDA levels decreased significantly (p0.05. Conclusion: Resistance training for 8 weeks increases antioxidant indexes and decreases oxidative indexes in postmenopausal women with breast cancer.

  7. Effect of 8 Weeks Resistance Training on Some Antioxidant/Oxidative Indexes in Postmenopausal Women with Breast Cancer

    Directory of Open Access Journals (Sweden)

    Fathollahi Shoorabeh F.

    2017-12-01

    Full Text Available Aims Breast cancer is the most common cancer among women that usually begins with abnormal growth and division of different breast cells. There is some evidence that there is an inverse relationship between levels of antioxidants and the risk of breast cancer. The purpose of this study was to investigate the effect of 8 weeks resistance training on some antioxidant/oxidative indexes in postmenopausal women with breast cancer. Materials & Methods In this semi-experimental study, in 2014, 30 postmenopausal women with breast cancer in Khorramabad city were selected by available sampling method and randomly divided into 2 groups: experimental group (n=16 and control group (n=14. The experimental group performed resistance training for 8 weeks, which started from 30% 1RM (one repetition maximum and reached 45-50% 1RM at the end of the eighth week. Blood samples were taken from subjects for the measurement of superoxide dismutase (SOD, glutathione peroxidase (GPX and malondialdehyde (MDA serum levels, 48 hours before and after the training protocol. Data were analyzed by SPSS 19 software using independent t-test and dependent t-test. Findings After performing 8 weeks of resistance training, serum levels of SOD and GPX significantly increased and MDA levels decreased significantly (p0.05. Conclusion Resistance training for 8 weeks increases antioxidant indexes and decreases oxidative indexes in postmenopausal women with breast cancer.

  8. A new index of hemodialysis adequacy: clearance x dialysis time / bioelectrical resistance.

    Science.gov (United States)

    Basile, Carlo; Vernaglione, Luigi; Lomonte, Carlo; Bellizzi, Vincenzo; Dambrosio, Nicola; Di Iorio, Biagio

    2010-01-01

    Kt/V urea was established as an index of hemodialysis (HD) adequacy. The use of V urea (as derived by the Watson et al formulae) as a normalizing factor has been questioned, and alternative parameters such as body weight 0.67 (W 0.67), body surface area (BSA), resting energy expenditure (REE), high metabolic rate organ (HMRO) mass and liver size (LV) have been proposed (respective HD adequacy indices: Kt/W 0.67, Kt/BSA, Kt/REE, Kt/HMRO and Kt/LV). The present study aimed to calculate the 6 previously described normalizing factors (all obtained utilizing anthropometric variables) and to measure bioelectrical resistance (R), an independent and directly achievable biological parameter, in 481 white, disease-free individuals and 270 white prevalent HD patients, pair-matched by age, body weight and height, after stratification by sex. Further, we aimed to evaluate the effect of substituting BSA, W 0.67, REE, HMRO, LV and R for V urea as denominator in Kt/V urea on the distribution of target dialysis dose in a cohort of 1,058 white prevalent HD patients. All individuals underwent 1 single-frequency bioelectrical impedance measurement, on the nondominant side of the body, injecting 800 μA at 50 kHz alternating sinusoidal current with a standard tetrapolar technique. When comparing pair-matched disease-free men and women with HD men and women, respectively, only R was statistically significantly different (pcalculations which utilize anthropometric variables. In contrast, R is a biological parameter which can be directly measured in the clinical setting by means of a simple, low-cost, fast and repeatable procedure. Even though Kt/R is probably the most appropriate method for scaling dialysis dose among those evaluated in the present study, further work is required to develop these concepts and translate them into rigorous outcome-based adequacy targets suitable for clinical usage.

  9. Amino acid profiles of young adults differ by sex, body mass index and insulin resistance.

    Science.gov (United States)

    Guevara-Cruz, M; Vargas-Morales, J M; Méndez-García, A L; López-Barradas, A M; Granados-Portillo, O; Ordaz-Nava, G; Rocha-Viggiano, A K; Gutierrez-Leyte, C A; Medina-Cerda, E; Rosado, J L; Morales, J C; Torres, N; Tovar, A R; Noriega, L G

    2018-04-01

    An increase in plasma branched-chain amino acids is associated with a higher risk of developing type 2 diabetes and cardiovascular diseases. However, little is known about the basal plasma amino acid concentrations in young adults. Our aim was to determine the plasma amino acid profiles of young adults and to evaluate how these profiles were modified by sex, body mass index (BMI) and insulin resistance (IR). We performed a transversal study with 608 Mexican young adults aged 19.9 ± 2.4 years who were applicants to the Universidad Autónoma de San Luis Potosí. The subjects underwent a physical examination and provided a clinical history and a blood sample for biochemical, hormonal and amino acid analyses. The women had higher levels of arginine, aspartate and serine and lower levels of α-aminoadipic acid, cysteine, isoleucine, leucine, methionine, proline, tryptophan, tyrosine, urea and valine than the men. The obese subjects had higher levels of alanine, aspartate, cysteine, ornithine, phenylalanine, proline and tyrosine and lower levels of glycine, ornithine and serine than the normal weight subjects. Subjects with IR (defined as HOMA > 2.5) had higher levels of arginine, alanine, aspartate, isoleucine, leucine, phenylalanine, proline, tyrosine, taurine and valine than the subjects without IR. Furthermore, we identified two main groups in the subjects with obesity and/or IR; one group was composed of amino acids that positively correlated with the clinical, biochemical and hormonal parameters, whereas the second group exhibited negative correlations. This study demonstrates that young adults with obesity or IR have altered amino acid profiles characterized by an increase in alanine, aspartate, proline and tyrosine and a decrease in glycine. Copyright © 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II

  10. Comparison of Resistance Index Some Potato Cultivars to the Colorado Potato Beetle, Leptinotarsa decemlineata (Say (Col.: Chrysomelidae

    Directory of Open Access Journals (Sweden)

    A. Ghassemi-Kahrizeh

    2016-03-01

    Full Text Available Introduction: Potato, Solanum tuberosum L. is an important crop with 5.24 million tons of production on 210,000 hectares of irrigated land in Iran. Several pests attack the potato crop which among them the Colorado potato beetle, Leptinotarsa decemlineata (Say, is the most important defoliating pest of potato throughout the world and Iran and considerably reduce crop yield. Growers rely on pesticides to control this pest in the field but this insect is well known for its rapid resistance development to pesticides, so that it has developed field resistance to nearly all insecticides used against it and it is now resistant to more than 40 chemical insecticides. The problems of insecticide resistance, combined with continuing environmental concerns associated with chemical pesticide use, have provided a considerable stimulus over the past 50 years for the development of alternative control methods. Host plant resistance is considered to be an important part of integrated pest management (IPM system of this pest, which is compatible with sustainable control methods and can reduce the use of chemical insecticides .With the aim of identifying the existence of resistance resources, a study was conducted to evaluate and comparison the resistance index (PRI of 33 potatocultivarsto the Colorado potato beetle. Detected resistant variety (ies could be used as a resistance source for IPM programs of this pest. Materials and Methods: Greenhouse and field experiments were conducted to compare resistance index (PRI of 33 potato cultivars to the Colorado potato beetle, Leptinotarsa decemlineata (Say, in Naghadeh region during 2007-2008. In a choice test, the numbers of attracted beetles to each cultivar was determined as antixenosis index in the field. Also, Percentage of larval and pupal mortality were determined and used as the antibiosis index under greenhouse conditions. To evaluate the tolerance index, infested and non infested plots were planted and

  11. High throughput resistance profiling of Plasmodium falciparum infections based on custom dual indexing and Illumina next generation sequencing-technology

    DEFF Research Database (Denmark)

    Nag, Sidsel; Dalgaard, Marlene Danner; Kofoed, Poul-Erik

    2017-01-01

    Genetic polymorphisms in P. falciparum can be used to indicate the parasite's susceptibility to antimalarial drugs as well as its geographical origin. Both of these factors are key to monitoring development and spread of antimalarial drug resistance. In this study, we combine multiplex PCR, custom...... designed dual indexing and Miseq sequencing for high throughput SNP-profiling of 457 malaria infections from Guinea-Bissau, at the cost of 10 USD per sample. By amplifying and sequencing 15 genetic fragments, we cover 20 resistance-conferring SNPs occurring in pfcrt, pfmdr1, pfdhfr, pfdhps, as well...

  12. Relação entre índice de resistência obtido pela ultra-sonografia Doppler transfortanela e o neurodesenvolvimento até o primeiro ano de vida em recém-nascidos a termo com encefalopatia hipóxico-isquêmica leve e moderada Relation between the resistance index obtained by the transfontanellar Doppler ultrasonography and the neurological development until the first year of life in term infants with mild or moderate hypoxic-ischaemic encephalopathy

    Directory of Open Access Journals (Sweden)

    Maria Helena Martins Garcia

    2007-12-01

    Full Text Available OBJETIVO: Avaliar a relação do índice de resistência (IR obtido pela ultra-sonografia Doppler transfontanela com o neurodesenvolvimento até um ano de idade, em recém-nascidos (RN a termo com encefalopatia hipóxica-isquêmica (EHI leve a moderada, secundária à asfixia intra-parto. MÉTODO: Estudo prospectivo em 20 RN com EHI leve a moderada, IR elevado no primeiro exame de Doppler, e sem doenças associadas ou anormalidades morfológicas cerebrais. Foram realizados exames seriados bimensais de Doppler transfontanela a partir do sétimo dia de vida, e avaliações clínicas mensais do neurodesenvolvimento no primeiro ano de vida. RESULTADOS: Houve normalização progressiva dos valores de IR até o último exame realizado. Cinco pacientes apresentaram normalização clínico-neurológica no período neonatal, após o primeiro exame de Doppler. Quinze lactentes apresentaram alterações neurológicas com resolução a partir do segundo trimestre de vida. CONCLUSÃO: Houve relação entre os períodos em que ocorreu a normalização dos valores de IR e a melhora clínica-neurológica.OBJECTIVE: To evaluate the relation between the resistance index (RI obtained by transfontanellar Doppler ultrasonography, and the neurodevelopment until one year of life, at term newborns with mild or moderate hypoxic-ischaemic encephalopathy due to intrapartum asphyxia. METHOD: 20 term newborns, with mild or moderate hypoxic-ischemic encephalopathy, high values of resistance index in the first exam, and without cerebral morfologic abnormalities or other diseases. They were submitted to serial bimonthly transfontanellar Doppler ultrasonography, from the seventh day of life on, and monthly clinical neurodevelopment assessment until one year of life. RESULTS: There was a progressive normalization of RI values until the last examination. In five cases there were clinical neurologic normalization in the neonatal period after the first Doppler exam. Fifteen infants

  13. Higher HOMA-IR index and correlated factors of insulin resistance in patients with IgA nephropathy.

    Science.gov (United States)

    Yang, Yue; Wei, Ri-Bao; Wang, Yuan-da; Zhang, Xue-Guang; Rong, Na; Tang, Li; Chen, Xiang-Mei

    2012-11-01

    To investigate the index of homeostasis model of insulin resistance (HOMA-IR) in IgA nephropathy (IgAN) patients, and to explore the possible correlated factors contributing to insulin resistance (IR) within these patients. There were 255 IgAN patients and 45 membranous nephropathy (MN) patients in our database. We identified 89 IgAN subjects and 21 MN subjects without diabetes and undergoing glucocorticoid therapy for at least 6 months. Data regarding physical examination, blood chemistry and renal pathology were collected from 89 IgAN subjects and 21 MN subjects. Then 62 IgAN patients and 19 MN patients with chronic kidney disease (CKD) Stage 1 - 2 were selected for the comparison of HOMA-IR index, 89 IgAN patients were selected for multiple regression analysis to test for correlated factors of HOMA-IR index with IgAN patients. Comparison between IgAN and MN show that HOMA-IR index was significantly higher in IgAN patients with CKD Stage 1 - 2. After logarithmic transformation with urine protein (UPr), Ln(UPr) (b = 0.186, p = 0.008), eGFR (b = -0.005, p = 0.014), > 50% of glomeruli with mesangial hypercellularity (b = 0.285, p = 0.027) and body mass index (BMI) (b = 0.039, p = 0.008) were correlated factors of HOMA-IR index in the multiple regression analysis. IgAN patients had higher HOMA-IR index compared with MN in the stages of CKD 1 - 2. For IgAN patients, more UPr, lower eGFR, > 50% of glomeruli with mesangial hypercellularity and higher BMI were correlated with IR.

  14. Endothelial function in young women with polycystic ovary syndrome (PCOS): Implications of body mass index (BMI) and insulin resistance.

    Science.gov (United States)

    El-Kannishy, Ghada; Kamal, Shaheer; Mousa, Amany; Saleh, Omayma; Badrawy, Adel El; Farahaty, Reham El; Shokeir, Tarek

    2010-01-01

    Evidence regarding endothelial function in both obese and nonobese women with PCOS is contradictory. It is unknown whether obese women with PCOS carry an increased risk related to body mass index (BMI). To identify endothelial function and investigate its relationship to body mass index and insulin resistance in young women with PCOS. Twenty-two obese women with PCOS (BMI 35.2 ± 3.2) as well as fourteen lean women (BMI 22.8 ± 2.1)with PCOS were included in the study. Fasting serum insulin, blood glucose were estimated and HOMA and Quicki index were calculated. All patients were subjected to ultrasound recording of brachial artery diameter at rest and after reactive hyperemia (FMD) for assessment of endothelial function. Ten age matched healthy females with normal BMI were chosen as a control group. There were higher basal insulin levels with lower Quicki index and higher HOMA index in women with PCOS than normal group, but the differences were significant only between obese PCOS subgroup and control. On the other hand, FMD was significantly and equally decreased in both groups of women with PCOS, compared with control subjects (3.7 ± 3.2% in the nonobese subgroup and 3.5 ± 2.8% in the obese one vs. 10.6 ± 4.1% in control subjects, P, 0.001). FMD was not correlated with BMI nor insulin resistance indices. Endothelial dysfunction is already present in young women with PCOS. In this patient group, it cannot be attributed to insulin resistance or obesity. © 2010 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.

  15. Gamma-glutamyltransferase, fatty liver index and hepatic insulin resistance are associated with incident hypertension in two longitudinal studies.

    Science.gov (United States)

    Bonnet, Fabrice; Gastaldelli, Amalia; Pihan-Le Bars, Florence; Natali, Andrea; Roussel, Ronan; Petrie, John; Tichet, Jean; Marre, Michel; Fromenty, Bernard; Balkau, Beverley

    2017-03-01

    We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hypertension and that hepatic insulin resistance plays a role. The association between liver markers and incident hypertension was analysed in two longitudinal studies of normotensive individuals, 2565 from the 9-year data from an epidemiological study on the insulin resistance cohort and the 321 from the 3-year 'Relationship between Insulin Sensitivity and Cardiovascular disease' cohort who had a measure of endogenous glucose production. The FLI is calculated from BMI, waist circumference, triglycerides and gamma-glutamyltransferase (GGT) and the hepatic insulin resistance index from endogenous glucose production and fasting insulin. The incidence of hypertension increased across the quartiles groups of both baseline GGT and alanine aminotransferase. After adjustment for sex, age, waist circumference, fasting glucose, smoking and alcohol intake, only GGT was significantly related with incident hypertension [standardized odds ratio: 1.21; 95% confidence interval (1.10-1.34); P = 0.0001]. The change in GGT levels over the follow-up was also related with an increased risk of hypertension, independently of changes in body weight. FLI analysed as a continuous value, or FLI at least 60 at baseline were predictive of incident hypertension in the multivariable model. In the RISC cohort, the hepatic insulin resistance index was positively related with the risk of 3-year incident hypertension [standardized odds ratio: 1.54 (1.07-2.22); P = 0.02]. Baseline GGT and FLI, as well as an increase in GGT over time, were associated with the risk of incident hypertension. Enhanced hepatic insulin resistance predicted the onset of hypertension and may be a link between liver markers and hypertension.

  16. Bend-resistant large mode area fiber with novel segmented cladding

    Science.gov (United States)

    Ma, Shaoshuo; Ning, Tigang; Pei, Li; Li, Jing; Zheng, Jingjing

    2018-01-01

    A novel structure of segment cladding fiber (SCF) with characteristics of bend-resistance and large-mode-area (LMA) is proposed. In this new structure, the high refractive index (RI) core is periodically surrounded by high RI fan-segmented claddings. Numerical investigations show that effective single-mode operation of the proposed fiber with mode field area of 700 μm2 can be achieved when the bending radius is 15 cm. Besides, this fiber is insensitive to the bending orientation at the ranging of [-180°, 180°]. The proposed design shows great potential in high power fiber lasers and amplifiers with compact structure.

  17. One-step patterning of double tone high contrast and high refractive index inorganic spin-on resist

    Energy Technology Data Exchange (ETDEWEB)

    Zanchetta, E.; Della Giustina, G.; Brusatin, G. [Industrial Engineering Department and INSTM, Via Marzolo 9, 35131 Padova (Italy)

    2014-09-14

    A direct one-step and low temperature micro-fabrication process, enabling to realize large area totally inorganic TiO₂ micro-patterns from a spin-on resist, is presented. High refractive index structures (up to 2 at 632 nm) without the need for transfer processes have been obtained by mask assisted UV lithography, exploiting photocatalytic titania properties. A distinctive feature not shared by any of the known available resists and boosting the material versatility, is that the system behaves either as a positive or as negative tone resist, depending on the process parameters and on the development chemistry. In order to explain the resist double tone behavior, deep comprehension of the lithographic process parameters optimization and of the resist chemistry and structure evolution during the lithographic process, generally uncommon in literature, is reported. Another striking property of the presented resist is that the negative tone shows a high contrast up to 19, allowing to obtain structures resolution down to 2 μm wide. The presented process and material permit to directly fabricate different titania geometries of great importance for solar cells, photo-catalysis, and photonic crystals applications.

  18. Development of RI Target Production Technology

    International Nuclear Information System (INIS)

    Jeong, Do Young; Ko, Kwang Hoon; Kim, Cheol Jung; Kim, Taek Soo; Rho, Si Pyo; Park, Hyun Min; Lim, Gwon; Cha, Yong Ho; Han, Jae Min

    2010-04-01

    This project was accomplished with an aim of productive technical development on the 'enriched target' which is used essentially in radioisotope production. The research was advanced systematically with target production pilot system configuration and core technical development. We composed Yb-176 productive pilot system which equip the chemical purification technique of medical treatment level and proved its capability. Possibilities to separate Zn-67 by the method of using the polarizing light in principle and to separate Zn-70 by the method of using the double optical pumping in theory were also proved. RI target production technologies are recognized excessively with monopolistic techniques of part atomic energy advanced nations such as Russia and US and they are come, but we prepared the opportunity will be able to complete a full cycle of like (RI material production -> RI target production -> RI application) with this project accomplishment. When considering only the direct demand of stable isotope which is used in various industrial, we forecast with the fact that RI target markets will become larger with the approximately 5 billion dollars in 2020 and this technology will contribute in the domestic rising industry creation with high value added

  19. Policy Activities in Europlanet 2020 RI

    Science.gov (United States)

    Giacomini, L.; Heward, A.; Mason, N.

    2017-09-01

    The Europlanet 2020 Research Infrastructure (RI) has received 9.945 million Euros from the European Commission to integrate planetary science across Europe, provide access to facilities, develop tools and build community cohesion. To help these processes and to increase engagement between our policy makers and the planetary science community, part of Europlanet 2020 RI's efforts are dedicated to building connections and organising activities for and within the European Parliament. Since September 2015, Europlanet 2020 RI has contacted all 134 Members of the European Parliament (MEPs) on the ITRE Committee. More than 20 individual briefings have been held to date with MEPS and/or their representatives. In November 2016, Europlanet 2020 RI organized a very successful exhibition in the European Parliament as part of the 8th European Innovation Summit and the STOA Annual Lecture, and a dinner debates was held in the on the 'Impact of the EU on planetary science' in April 2016. These events enable members of the Europlanet community, politicians and interested parties to come together and discuss views on topics of interest or concern to the space and planetary sectors. Efforts in recent years have led to important opportunities for our community to feed into reporting and consultative processes. In this talk we will discuss the results achieved in the last two years of activities and the next steps foreseen by Europlanet 2020 RI.

  20. Medical RI development plan of KOMAC

    Science.gov (United States)

    Kim, Kye-Ryung; Jung, Myung-Hwan; Yoon, Sang-Pil; Min, Yi-Sub; Cho, Yong-Sub

    2017-12-01

    Many kinds of radioisotopes (RIs) produced by the high energy (100 200 MeV) proton accelerators are developed by the foreign R&D institutes and the worldwide demands are being increased continuously. The RI production using high energy proton beam higher than 50 MeV was not considerable because of the limit of the proton beam energy from existing proton accelerator facilities in Korea before 2013. The available maximum proton energy was 50 MeV from MC-50 cyclotron of Korea Institute of Radiological and Medical Sciences (KIRAMS) at that time. After the construction of a 100 MeV high-current and high-energy proton accelerator and a new irradiation facility for the RI production in 2013 and 2016 by the Korea Multi-purpose Accelerator Complex (KOMAC) at Korea Atomic Energy Research Institute (KAERI), we can make a plan for the new RI production of Cu-67, Sr-82 and so on. In the medical application fields, the worldwide demand of Sr-82 is being increased rapidly during last several years and the domestic demand of Cu-67 is also expected to be increased in near future. And alpha-emitters, such as Ac-225 and Ra-223, are becoming attractive to the users in the medical science fields in the future. The RI development plan of KOMAC was specified recently reflecting the recent environment changes and requirements from the users. In this paper, the results and present status of RI production and R&D facilities, calculation results related to the RI production yields, and future plans is presented.

  1. Linezolid in the treatment of drug-resistant tuberculosis: the challenge of its narrow therapeutic index.

    Science.gov (United States)

    Wasserman, Sean; Meintjes, Graeme; Maartens, Gary

    2016-10-01

    Linezolid is an oxazolidinone with potent activity against M tuberculosis, and improves culture conversion and cure rates when added to treatment regimens for drug resistant tuberculosis. However, linezolid has a narrow therapeutic window, and the optimal dosing strategy that minimizes the substantial toxicity associated with linezolid's prolonged use in tuberculosis treatment has not been determined, limiting the potential impact of this anti-mycobacterial agent. This paper aims to review and summarize the current knowledge on linezolid for the treatment of drug-resistant tuberculosis. The focus is on the pharmacokinetic-pharmacodynamic determinants of linezolid's efficacy and toxicity in tuberculosis, and how this relates to defining an optimal dose. Mechanisms of linezolid toxicity and resistance, and the potential role of therapeutic drug monitoring are also covered. Expert commentary: Prospective pharmacokinetic-pharmacodynamic studies are required to define optimal therapeutic targets and to inform improved linezolid dosing strategies for drug-resistant tuberculosis.

  2. RI beam factory project at RIKEN

    CERN Document Server

    Motobayashi, T

    2003-01-01

    Construction of the RI beam factory project in the first phase has started. The aim of the project is to provide intense radio-isotopes (RI) beams at energies of several hundred MeV/nucleon in a wide range of atomic masses. These beams will be produced by the projectile fragmentation of primary beams accelerated by a cascade of the existing ring cyclotron and a series of new ring cyclotrons. Improvements of the existing facility made for the new cyclotron complex have extended the energy range of available beams, which already opened new domains of study.

  3. Tüüri vioolakontserdi esiettekanne

    Index Scriptorium Estoniae

    2008-01-01

    24. okt. toovad Taanis Sonderborgis maailmaesiettekandele Erkki-Sven Tüüri Vioolakontserdi "Illuminatio" norra vioolamängija Lars Anders Tomter ja Lõuna- Jüütimaa Sümfooniaorkester, mida juhatab Vladimir Ziva. Evelyn Glennie ja New Jersey Sümfooniaorkester Neeme Järvi juhatusel esitavad 10. okt. USAs Newarkis ja 12. okt. New Brunswickis Tüüri 4. sümfoonia "Magma". Sellega seoses esineb Tüür loengutega oma loomingust järgmistes kõrgkoolides: New York Univerdity, Juilliard Scool of Music, Princeton University ja Montclair State University

  4. Influence of the column rectangularity index and of the boundary conditions in the punching resistance of slab-column connections

    Directory of Open Access Journals (Sweden)

    O. S. PAIVA

    Full Text Available Experimental evidence indicates that both the column rectangularity index and the boundary conditions of the connection may affect the ultimate punching resistance. This paper presents general aspects of these topics and, through the analysis of experimental results of tests on 131 slabs, evaluates the accuracy and suitability of recommendations presented by ABNT NBR 6118, Eurocode 2, ACI 318 and fib Model Code 2010. Experimental results showed that the security level of normative estimates trend to reduce as the column rectangularity increases, and in some cases, the punching resistance was overestimated. Finally, adjustments are suggested in equations presented by NBR 6118 and MC2010 in order to eliminate this trend of unsafe results.

  5. Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance - The Inter99 study

    DEFF Research Database (Denmark)

    Lau, Cathrine; Pedersen, Oluf; Færch, Kristine

    2005-01-01

    , and insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). Multiple regressions were performed with HOMA-IR as the dependent variable and carbohydrate-related factors as explanatory variables. All models were adjusted for age, sex, smoking, physical activity......, total energy intake, BMI, and waist circumference. RESULTS - intake of lactose was positively associated with HOMA-IR (P < 0.0001), whereas daily glycemic load and intake of glucose, fructose, dietary fiber, total carbohydrate, fruit, and vegetables were inversely associated with HOMA-IR (P < 0...

  6. Verification of Representative Sampling in RI waste

    International Nuclear Information System (INIS)

    Ahn, Hong Joo; Song, Byung Cheul; Sohn, Se Cheul; Song, Kyu Seok; Jee, Kwang Yong; Choi, Kwang Seop

    2009-01-01

    For evaluating the radionuclide inventories for RI wastes, representative sampling is one of the most important parts in the process of radiochemical assay. Sampling to characterized RI waste conditions typically has been based on judgment or convenience sampling of individual or groups. However, it is difficult to get a sample representatively among the numerous drums. In addition, RI waste drums might be classified into heterogeneous wastes because they have a content of cotton, glass, vinyl, gloves, etc. In order to get the representative samples, the sample to be analyzed must be collected from selected every drum. Considering the expense and time of analysis, however, the number of sample has to be minimized. In this study, RI waste drums were classified by the various conditions of the half-life, surface dose, acceptance date, waste form, generator, etc. A sample for radiochemical assay was obtained through mixing samples of each drum. The sample has to be prepared for radiochemical assay and although the sample should be reasonably uniform, it is rare that a completely homogeneous material is received. Every sample is shredded by a 1 ∼ 2 cm 2 diameter and a representative aliquot taken for the required analysis. For verification of representative sampling, classified every group is tested for evaluation of 'selection of representative drum in a group' and 'representative sampling in a drum'

  7. Comprehension of radiation for RI license

    International Nuclear Information System (INIS)

    Guk, Jin Sun

    2005-08-01

    This book starts with theoretical nuclear energy which explains technical terms such as nuclear physics and chemistry, RI and utilization of radiation, radiochemistry and radiation chemistry, radiation biology. It also explains radiation measurements technology including radiation detector and measurements radiation measurements circuit, measuring of energy spectrum. Radiation protection monitoring for radiation protection. It deals with nuclear law, enforcement regulation and ordinance.

  8. Decontamination manual of RI handling laboratory

    International Nuclear Information System (INIS)

    Wadachi, Yoshiki

    2004-01-01

    Based on experiences in Japan Atomic Energy Research Institute (JAERI), the essential and practical knowledge of radioactive contamination and its decontamination, and the method and procedure of floor decontamination are described for researcher and managing person in charge of handling radioisotopes (RI) in RI handling laboratories. Essential knowledge concerns the uniqueness of solid surface contamination derived from RI half lives and quantities, surface contamination density limit, and mode/mechanism of contamination. The principle of decontamination is a single conduct with recognition of chemical form of the RI under use. As the practical knowledge, there are physical and chemical methods of solid surface decontamination. The latter involves use of inorganic acids, chelaters and surfactants. Removal and replacement of contaminated solid like floor material are often effective. Distribution mapping of surface contamination can be done by measuring the radioactivity in possibly contaminated areas, and is useful for planning of effective decontamination. Floor surface decontamination is for the partial and spread areas of the floor. It is essential to conduct the decontamination with reagent from the highly to less contaminated areas. Skin decontamination with either neutral detergent or titanium oxide is also described. (N.I.)

  9. Teel kriisist õigusriiki / Jüri Raidla

    Index Scriptorium Estoniae

    Raidla, Jüri, 1957-

    1990-01-01

    ri Raidla, justiitsminister (kinnitati 17. 04. 1990). Sündinud 1957. a. Pärnus, 1980. a. lõpetas Tartu Ülikooli õigusteaduskonna, kaitses 12. 02. 1987. a. Leningradi Ülikoolis väitekirja "Mehaaniliste transpordivahenditega kahju tekitamisest tulenevad kohustused"

  10. Leg joint power output during progressive resistance FES-LCE cycling in SCI subjects: developing an index of fatigue

    Directory of Open Access Journals (Sweden)

    Faghri Pouran D

    2008-04-01

    Full Text Available Abstract Background The purpose of this study was to investigate the biomechanics of the hip, knee and ankle during a progressive resistance cycling protocol in an effort to detect and measure the presence of muscle fatigue. It was hypothesized that knee power output can be used as an indicator of fatigue in order to assess the cycling performance of SCI subjects. Methods Six spinal cord injured subjects (2 incomplete, 4 complete between the ages of twenty and fifty years old and possessing either a complete or incomplete spinal cord injury at or below the fourth cervical vertebra participated in this study. Kinematic data and pedal forces were recorded during cycling at increasing levels of resistance. Ankle, knee and hip power outputs and resultant pedal force were calculated. Ergometer cadence and muscle stimulation intensity were also recorded. Results The main findings of this study were: (a ankle and knee power outputs decreased, whereas hip power output increased with increasing resistance, (b cadence, stimulation intensity and resultant pedal force in that combined order were significant predictors of knee power output and (c knowing the value of these combined predictors at 10 rpm, an index of fatigue can be developed, quantitatively expressing the power capacity of the knee joint with respect to a baseline power level defined as fatigue. Conclusion An index of fatigue was successfully developed, proportionalizing knee power capacity during cycling to a predetermined value of fatigue. The fatigue index value at 0/8th kp, measured 90 seconds into active, unassisted pedaling was 1.6. This indicates initial power capacity at the knee to be 1.6 times greater than fatigue. The fatigue index decreased to 1.1 at 2/8th kp, representing approximately a 30% decrease in the knee's power capacity within a 4 minute timespan. These findings suggest that the present cycling protocol is not sufficient for a rider to gain the benefits of FES and thus

  11. Leg joint power output during progressive resistance FES-LCE cycling in SCI subjects: developing an index of fatigue.

    Science.gov (United States)

    Haapala, Stephenie A; Faghri, Pouran D; Adams, Douglas J

    2008-04-26

    The purpose of this study was to investigate the biomechanics of the hip, knee and ankle during a progressive resistance cycling protocol in an effort to detect and measure the presence of muscle fatigue. It was hypothesized that knee power output can be used as an indicator of fatigue in order to assess the cycling performance of SCI subjects. Six spinal cord injured subjects (2 incomplete, 4 complete) between the ages of twenty and fifty years old and possessing either a complete or incomplete spinal cord injury at or below the fourth cervical vertebra participated in this study. Kinematic data and pedal forces were recorded during cycling at increasing levels of resistance. Ankle, knee and hip power outputs and resultant pedal force were calculated. Ergometer cadence and muscle stimulation intensity were also recorded. The main findings of this study were: (a) ankle and knee power outputs decreased, whereas hip power output increased with increasing resistance, (b) cadence, stimulation intensity and resultant pedal force in that combined order were significant predictors of knee power output and (c) knowing the value of these combined predictors at 10 rpm, an index of fatigue can be developed, quantitatively expressing the power capacity of the knee joint with respect to a baseline power level defined as fatigue. An index of fatigue was successfully developed, proportionalizing knee power capacity during cycling to a predetermined value of fatigue. The fatigue index value at 0/8th kp, measured 90 seconds into active, unassisted pedaling was 1.6. This indicates initial power capacity at the knee to be 1.6 times greater than fatigue. The fatigue index decreased to 1.1 at 2/8th kp, representing approximately a 30% decrease in the knee's power capacity within a 4 minute timespan. These findings suggest that the present cycling protocol is not sufficient for a rider to gain the benefits of FES and thus raises speculation as to whether or not progressive resistance

  12. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome - Brazilian Metabolic Syndrome Study (BRAMS)

    OpenAIRE

    Geloneze, B; Vasques, ACJ; Stabe, CFC; Pareja, JC; Rosado, LEFPD; de Queiroz, EC; Tambascia, MA

    2009-01-01

    Objective: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. Methods: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 9011 percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. Results: In the he...

  13. Triglyceride Glucose-Body Mass Index Is a Simple and Clinically Useful Surrogate Marker for Insulin Resistance in Nondiabetic Individuals.

    Science.gov (United States)

    Er, Leay-Kiaw; Wu, Semon; Chou, Hsin-Hua; Hsu, Lung-An; Teng, Ming-Sheng; Sun, Yu-Chen; Ko, Yu-Lin

    2016-01-01

    Insulin resistance (IR) and the consequences of compensatory hyperinsulinemia are pathogenic factors for a set of metabolic abnormalities, which contribute to the development of diabetes mellitus and cardiovascular diseases. We compared traditional lipid levels and ratios and combined them with fasting plasma glucose (FPG) levels or adiposity status for determining their efficiency as independent risk factors for IR. We enrolled 511 Taiwanese individuals for the analysis. The clinical usefulness of various parameters--such as traditional lipid levels and ratios; visceral adiposity indicators, visceral adiposity index (VAI), and lipid accumulation product (LAP); the product of triglyceride (TG) and FPG (the TyG index); TyG with adiposity status (TyG-body mass index [BMI]) and TyG-waist circumference index [WC]); and adipokine levels and ratios--was analyzed to identify IR. For all lipid ratios, the TG/high-density lipoprotein cholesterol (HDL-C) ratio had the highest additional percentage of variation in the homeostasis model assessment of insulin resistance (HOMA-IR; 7.0% in total); for all variables of interest, TyG-BMI and leptin-adiponectin ratio (LAR) were strongly associated with HOMA-IR, with 16.6% and 23.2% of variability, respectively. A logistic regression analysis revealed similar patterns. A receiver operating characteristic (ROC) curve analysis indicated that TG/HDL-C was a more efficient IR discriminator than other lipid variables or ratios. The area under the ROC curve (AUC) for VAI (0.734) and TyG (0.708) was larger than that for TG/HDL-C (0.707). TyG-BMI and LAR had the largest AUC (0.801 and 0.801, respectively). TyG-BMI is a simple, powerful, and clinically useful surrogate marker for early identification of IR.

  14. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

    Science.gov (United States)

    Manning, Alisa K.; Hivert, Marie-France; Scott, Robert A.; Grimsby, Jonna L.; Bouatia-Naji, Nabila; Chen, Han; Rybin, Denis; Liu, Ching-Ti; Bielak, Lawrence F.; Prokopenko, Inga; Amin, Najaf; Barnes, Daniel; Cadby, Gemma; Hottenga, Jouke-Jan; Ingelsson, Erik; Jackson, Anne U.; Johnson, Toby; Kanoni, Stavroula; Ladenvall, Claes; Lagou, Vasiliki; Lahti, Jari; Lecoeur, Cecile; Liu, Yongmei; Martinez-Larrad, Maria Teresa; Montasser, May E.; Navarro, Pau; Perry, John R. B.; Rasmussen-Torvik, Laura J.; Salo, Perttu; Sattar, Naveed; Shungin, Dmitry; Strawbridge, Rona J.; Tanaka, Toshiko; van Duijn, Cornelia M.; An, Ping; de Andrade, Mariza; Andrews, Jeanette S.; Aspelund, Thor; Atalay, Mustafa; Aulchenko, Yurii; Balkau, Beverley; Bandinelli, Stefania; Beckmann, Jacques S.; Beilby, John P.; Bellis, Claire; Bergman, Richard N.; Blangero, John; Boban, Mladen; Boehnke, Michael; Boerwinkle, Eric; Bonnycastle, Lori L.; Boomsma, Dorret I.; Borecki, Ingrid B.; Böttcher, Yvonne; Bouchard, Claude; Brunner, Eric; Budimir, Danijela; Campbell, Harry; Carlson, Olga; Chines, Peter S.; Clarke, Robert; Collins, Francis S.; Corbatón-Anchuelo, Arturo; Couper, David; de Faire, Ulf; Dedoussis, George V; Deloukas, Panos; Dimitriou, Maria; Egan, Josephine M; Eiriksdottir, Gudny; Erdos, Michael R.; Eriksson, Johan G.; Eury, Elodie; Ferrucci, Luigi; Ford, Ian; Forouhi, Nita G.; Fox, Caroline S; Franzosi, Maria Grazia; Franks, Paul W; Frayling, Timothy M; Froguel, Philippe; Galan, Pilar; de Geus, Eco; Gigante, Bruna; Glazer, Nicole L.; Goel, Anuj; Groop, Leif; Gudnason, Vilmundur; Hallmans, Göran; Hamsten, Anders; Hansson, Ola; Harris, Tamara B.; Hayward, Caroline; Heath, Simon; Hercberg, Serge; Hicks, Andrew A.; Hingorani, Aroon; Hofman, Albert; Hui, Jennie; Hung, Joseph; Jarvelin, Marjo Riitta; Jhun, Min A.; Johnson, Paul C.D.; Jukema, J Wouter; Jula, Antti; Kao, W.H.; Kaprio, Jaakko; Kardia, Sharon L. R.; Keinanen-Kiukaanniemi, Sirkka; Kivimaki, Mika; Kolcic, Ivana; Kovacs, Peter; Kumari, Meena; Kuusisto, Johanna; Kyvik, Kirsten Ohm; Laakso, Markku; Lakka, Timo; Lannfelt, Lars; Lathrop, G Mark; Launer, Lenore J.; Leander, Karin; Li, Guo; Lind, Lars; Lindstrom, Jaana; Lobbens, Stéphane; Loos, Ruth J. F.; Luan, Jian’an; Lyssenko, Valeriya; Mägi, Reedik; Magnusson, Patrik K. E.; Marmot, Michael; Meneton, Pierre; Mohlke, Karen L.; Mooser, Vincent; Morken, Mario A.; Miljkovic, Iva; Narisu, Narisu; O’Connell, Jeff; Ong, Ken K.; Oostra, Ben A.; Palmer, Lyle J.; Palotie, Aarno; Pankow, James S.; Peden, John F.; Pedersen, Nancy L.; Pehlic, Marina; Peltonen, Leena; Penninx, Brenda; Pericic, Marijana; Perola, Markus; Perusse, Louis; Peyser, Patricia A; Polasek, Ozren; Pramstaller, Peter P.; Province, Michael A.; Räikkönen, Katri; Rauramaa, Rainer; Rehnberg, Emil; Rice, Ken; Rotter, Jerome I.; Rudan, Igor; Ruokonen, Aimo; Saaristo, Timo; Sabater-Lleal, Maria; Salomaa, Veikko; Savage, David B.; Saxena, Richa; Schwarz, Peter; Seedorf, Udo; Sennblad, Bengt; Serrano-Rios, Manuel; Shuldiner, Alan R.; Sijbrands, Eric J.G.; Siscovick, David S.; Smit, Johannes H.; Small, Kerrin S.; Smith, Nicholas L.; Smith, Albert Vernon; Stančáková, Alena; Stirrups, Kathleen; Stumvoll, Michael; Sun, Yan V.; Swift, Amy J.; Tönjes, Anke; Tuomilehto, Jaakko; Trompet, Stella; Uitterlinden, Andre G.; Uusitupa, Matti; Vikström, Max; Vitart, Veronique; Vohl, Marie-Claude; Voight, Benjamin F.; Vollenweider, Peter; Waeber, Gerard; Waterworth, Dawn M; Watkins, Hugh; Wheeler, Eleanor; Widen, Elisabeth; Wild, Sarah H.; Willems, Sara M.; Willemsen, Gonneke; Wilson, James F.; Witteman, Jacqueline C.M.; Wright, Alan F.; Yaghootkar, Hanieh; Zelenika, Diana; Zemunik, Tatijana; Zgaga, Lina; Wareham, Nicholas J.; McCarthy, Mark I.; Barroso, Ines; Watanabe, Richard M.; Florez, Jose C.; Dupuis, Josée; Meigs, James B.; Langenberg, Claudia

    2013-01-01

    Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and beta-cell dysfunction, but contributed little to our understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways may be uncovered by accounting for differences in body mass index (BMI) and potential interaction between BMI and genetic variants. We applied a novel joint meta-analytical approach to test associations with fasting insulin (FI) and glucose (FG) on a genome-wide scale. We present six previously unknown FI loci at P<5×10−8 in combined discovery and follow-up analyses of 52 studies comprising up to 96,496non-diabetic individuals. Risk variants were associated with higher triglyceride and lower HDL cholesterol levels, suggestive of a role for these FI loci in insulin resistance pathways. The localization of these additional loci will aid further characterization of the role of insulin resistance in T2D pathophysiology. PMID:22581228

  15. Hyperemic stenosis resistance index for evaluation of functional coronary lesion severity

    NARCIS (Netherlands)

    Meuwissen, Martijn; Siebes, Maria; Chamuleau, Steven A. J.; van Eck-Smit, Berthe L. F.; Koch, Karel T.; de Winter, Robbert J.; Tijssen, Jan G. P.; Spaan, Jos A. E.; Piek, Jan J.

    2002-01-01

    Background-Both coronary blood flow velocity reserve (CFVR) and myocardial fractional flow reserve (FFR) are used to evaluate the hemodynamic severity of coronary lesions. However, discordant results between CFVR and FFR have been observed in 25%, to 30% of intermediate coronary lesions. An index of

  16. Multiple antibiotic resistance iIndex of EscherichiaColi isolates in a ...

    African Journals Online (AJOL)

    Background: The effectiveness of available antibiotics is reducing as microorganisms device means of evading its effects, resulting in the development of superbugs. Pathogens previously susceptible are becoming resistant, and spreading beyond the hospital environment. This change is a major concern for infection ...

  17. A summary index for antimicrobial resistance in food animals in the Netherlands.

    NARCIS (Netherlands)

    Havelaar, Arie H; Graveland, Haitske; van de Kassteele, Jan; Zomer, Tizza P; Veldman, Kees; Bouwknegt, Martijn

    2017-01-01

    The Dutch government has set targets for reduction of antimicrobial usage in food animals, stipulating a 50% reduction in usage (on a weight basis) in 2013 as compared to 2009 and a 70% decrease in 2015. A monitoring program has been instituted to evaluate the impact on antimicrobial resistance

  18. ri Ratas : Tallinnasse rahvuspark! / Jüri Ratas ; interv. Ilmar Palli

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2005-01-01

    Tallinna uus linnapea Jüri Ratas rohelisest vööndist, keskkonnakaitsest, ohtlikest veostest, teede olukorrast, linna elukeskkonnast, asotsiaalide probleemist ning kohaliku omavalitsuse ja riigi koostööst

  19. Evaluation the index of ophthalmic arteries in diabetic patients with retinopathy compared to diabetic patients without retinopathy using color Doppler ultrasound

    Directory of Open Access Journals (Sweden)

    Mohammad Ghasem Hanafi

    2016-12-01

    Full Text Available Diabetic retinopathy is the most common eye complication in diabetic patients that early detection of this complication is essential. The aim of this study was to evaluate ophthalmic artery index in diabetic retinopathy by Doppler ultrasound. . In this cross-sectional study, 64 patients were studied in 4 groups (healthy, diabetic without retinopathy, background retinopathy and proliferative retinopathy. Resistance index (RI and Pulsatile Index (PI were assessed by color Doppler ultrasound. The obtained data were analyzed by ANOVA and chi-square test and ROC curve. RI in diabetic patients with proliferative retinopathy has the highest mean (0.83 and the lowest mean was observed in healthy subjects (0.54 (P <0.001 as well as in PI, the highest rate was in diabetic patients with proliferative retinopathy (1.41 and the lowest was in healthy subjects (0.92 (P <0.001. The results of our study showed that the sensitivity, specificity, positive and negative predictive values and overall accuracy of RI and PI in diabetic patients with proliferative retinopathy in the best cut-off points (0.645 and 1.0175 respectively were 100%.Ophthalmic artery index RI and PI was significantly increased in patients with diabetic retinopathy and the sensitivity and specificity for detection retinopathy was 100%. Color Doppler ultrasound method is more efficient for screening diabetic patients with retinopathy.

  20. Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial.

    Science.gov (United States)

    El-Hajj Fuleihan, Ghada; Baddoura, Rafic; Habib, Robert H; Halaby, Georges; Arabi, Asma; Rahme, Maya; Singh, Ravinder J; Kassem, Moustapha; Mahfoud, Ziyad; Hoteit, Maha; Daher, Rose T; Kassir, Mohamed-Faisal

    2016-08-01

    It is unclear whether and at what dose vitamin D supplementation affects insulin resistance (IR). We sought to investigate whether vitamin D at doses higher than currently recommended decreases indexes of IR in an ambulatory population of overweight elderly subjects. This double-blind, randomized, controlled multicenter trial enrolled 257 elderly overweight individuals aged ≥65 y with baseline 25-hydroxyvitamin D [25(OH)D] concentrations between 10 and 30 ng/mL. All subjects received 1000 mg calcium citrate/d, with vitamin D administered weekly at an equivalent dose of 600 or 3750 IU/d. The homeostasis model assessment (HOMA) of IR index at 1 y was the primary outcome. We also assessed the McAuley index. In total, 222 subjects (55% women) with a mean ± SD age and body mass index (BMI; in kg/m(2)) of 71 ± 4 y and 30 ± 4, respectively, completed the study. Subjects' baseline characteristics, including IR indexes, were similar across groups: 69% had prediabetes, 54% had hypertension (47% were taking antihypertensive medications), and 60% had hyperlipidemia, nearly half of whom were receiving lipid-lowering drugs. At 1 y, mean ± SD serum 25(OH)D increased from 20 ± 7 to 26 ± 7 ng/mL in the low-dose arm (P vitamin D dose, baseline serum 25(OH)D, or change in 25(OH)D. Vitamin D3 at 3750 IU/d did not improve HOMA-IR compared with the Institute of Medicine Recommended Dietary Allowance of 600 IU/d in elderly overweight individuals. This trial was registered at clinicaltrials.gov as NCT01315366. © 2016 American Society for Nutrition.

  1. The effects of cinnamon on glycemic indexes and insulin resistance in adult male diabetic rats with streptozotocin

    Directory of Open Access Journals (Sweden)

    SEbrahim Hosseini

    2015-02-01

    Full Text Available Background: Diabetes is a common disease that for its treatment and control different methods are recommended such as the use of natural remedies and lifestyle modification. Since the use of herbal medicines have less side effects than many chemical drugs, hence, this study aimed to investigate the effect of cinnamon extract on blood glucose, insulin and insulin resistance in diabetic rats with streptozotocin. Materials and Methods: This experimental study was conducted on 40 adult male rats, that were randomly divided into 4 groups including non diabetic control, diabetic control and two experimental groups receiving doses 60mg/kg of cinnamon extract for 3 and 6 weeks. At the end, by phlebotomizing of rats' heart, blood glucose and insulin were measured and using HOMA score insulin resistance was measured. To be normal data distribution, Kolmogorov-Smirnov test was done and data analyzed by SPSS-20 software and ANOVA and post hoc Tukey tests. Results: The results showed that in the group receiving the cinnamon extract, glycemic and insulin indexes were significantly adjusted. Conclusion: Cinnamon is probably due to have flavonoid and antioxidant compounds with antioxidant by increasing glucose uptake via the different body cells and due to reduction of oxidative stress level led to adjust glycemic and insulin indexes of blood

  2. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS).

    Science.gov (United States)

    Geloneze, Bruno; Vasques, Ana Carolina Junqueira; Stabe, Christiane França Camargo; Pareja, José Carlos; Rosado, Lina Enriqueta Frandsen Paez de Lima; Queiroz, Elaine Cristina de; Tambascia, Marcos Antonio

    2009-03-01

    To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p 2.7 and HOMA2-IR > 1.8; and, for MS were: HOMA1-IR > 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR > 1.4 (sensitivity: 79.2%; specificity: 61.2%). The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations.

  3. Rembrandt Kadrioru lossis / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2000-01-01

    Kadrioru lossi kuppelsaali tundmatu meistri laemaali maalimise ajalugu. Maali aluseks on Rembrandti maal "Diana suplus". Laemaal on maalitud Magdalena de Passe (1600-1638) vasegravüüri põhjal, mis on tehtud Rembrandti maalist. Rembrandt on lähtunud Antonio Tempesta (1555-1630) kahest gravüürist, viimane on lähtunud Otto van Veeni (1556-1629) maalist

  4. A novel insulin resistance index to monitor changes in insulin sensitivity and glucose tolerance: the ACT NOW study.

    Science.gov (United States)

    Tripathy, Devjit; Cobb, Jeff E; Gall, Walter; Adam, Klaus-Peter; George, Tabitha; Schwenke, Dawn C; Banerji, MaryAnn; Bray, George A; Buchanan, Thomas A; Clement, Stephen C; Henry, Robert R; Kitabchi, Abbas E; Mudaliar, Sunder; Ratner, Robert E; Stentz, Frankie B; Reaven, Peter D; Musi, Nicolas; Ferrannini, Ele; DeFronzo, Ralph A

    2015-05-01

    The objective was to test the clinical utility of Quantose M(Q) to monitor changes in insulin sensitivity after pioglitazone therapy in prediabetic subjects. Quantose M(Q) is derived from fasting measurements of insulin, α-hydroxybutyrate, linoleoyl-glycerophosphocholine, and oleate, three nonglucose metabolites shown to correlate with insulin-stimulated glucose disposal. Participants were 428 of the total of 602 ACT NOW impaired glucose tolerance (IGT) subjects randomized to pioglitazone (45 mg/d) or placebo and followed for 2.4 years. At baseline and study end, fasting plasma metabolites required for determination of Quantose, glycated hemoglobin, and oral glucose tolerance test with frequent plasma insulin and glucose measurements to calculate the Matsuda index of insulin sensitivity were obtained. Pioglitazone treatment lowered IGT conversion to diabetes (hazard ratio = 0.25; 95% confidence interval = 0.13-0.50; P < .0001). Although glycated hemoglobin did not track with insulin sensitivity, Quantose M(Q) increased in pioglitazone-treated subjects (by 1.45 [3.45] mg·min(-1)·kgwbm(-1)) (median [interquartile range]) (P < .001 vs placebo), as did the Matsuda index (by 3.05 [4.77] units; P < .0001). Quantose M(Q) correlated with the Matsuda index at baseline and change in the Matsuda index from baseline (rho, 0.85 and 0.79, respectively; P < .0001) and was progressively higher across closeout glucose tolerance status (diabetes, IGT, normal glucose tolerance). In logistic models including only anthropometric and fasting measurements, Quantose M(Q) outperformed both Matsuda and fasting insulin in predicting incident diabetes. In IGT subjects, Quantose M(Q) parallels changes in insulin sensitivity and glucose tolerance with pioglitazone therapy. Due to its strong correlation with improved insulin sensitivity and its ease of use, Quantose M(Q) may serve as a useful clinical test to identify and monitor therapy in insulin-resistant patients.

  5. Use of RI-cone penetrometer in clay foundations

    International Nuclear Information System (INIS)

    Mimura, Mamoru; Shibata, Toru; Shrivastava, A.K.

    1993-01-01

    RI cone penetrometer tests are carried out at four different sites. The foundation grounds discussed here mainly consist of clayey materials. The measured results by RI cone penetrometers are shown for Kyobashi, Hachirougata, Kurihama and Kinkai Bay site. According to comparison of water content and density profiles by RI cone measurement with the conventional testing results, RI cone penetrometers are proved to be versatile tools for site investigation. Settlement assessment by RI cone penetrometer is also discussed by exemplifying the embankment at Kinkai Bay site. Elasto-vis-coplastic finite element analysis correspondingly performed strongly supports the RI cone based assessment. Repeated use of RI cone penetrometer with the advance of construction enables us to assess the consolidation process of the clay foundation. (author)

  6. Insulin resistance in a large cohort of women with polycystic ovary syndrome: a comparison between euglycaemic-hyperinsulinaemic clamp and surrogate indexes.

    Science.gov (United States)

    Tosi, Flavia; Bonora, Enzo; Moghetti, Paolo

    2017-12-01

    Could surrogate indexes identify insulin resistant individuals among women with polycystic ovary syndrome (PCOS)? Surrogate indexes may be able to rule in, but not rule out, insulin resistance in women with PCOS. Insulin resistance is a typical finding of women with PCOS and most clinical information on this issue is based upon surrogate indexes of insulin resistance. However, data on the performance of these indexes in PCOS women are very limited. A retrospective analysis of 406 women referred to our outpatient clinic for hyperandrogenism and/or menstrual dysfunction and submitted to hyperinsulinemic euglycaemic clamp between 1998 and 2015. In total, 375 of these women had PCOS by the Rotterdam criteria and were included in the study. Six surrogate indexes of insulin sensitivity were calculated from glucose and insulin levels, either at fasting (homeostasis model assessment (HOMA), glucose/insulin (G/I) ratio and quantitative insulin sensitivity check index (QUICKI)) or after oral glucose load (Gutt, Stumvoll0-120 and Matsuda). Overall, insulin resistance, as identified by the M-clamp value, was found in 74.9% of these women. The percentage was 59.3% in normal-weight vs 77.5% in overweight and 93.9% in obese subjects. All surrogate indexes were highly correlated with the M-clamp values. However, their ability to identify insulin resistant individuals was limited, in terms of sensitivity and especially in normal-weight subjects. ROC analysis showed similar performances of these indexes (AUC values 0.782-0.817). Potential referral bias of PCOS patients may have caused overestimation of the prevalence of insulin resistance in these women. By using surrogate indexes many subjects with PCOS may be erroneously diagnosed as insulin sensitive, especially among normal-weight women. These indexes can be used to rule in, but not rule out, insulin resistance in PCOS. Academic grants to P. Moghetti from the University of Verona. All authors declare no conflict of interest. N

  7. Results of the freeze resistance test, swelling index and coefficient of permeability of finegrained mining waste reinforced with cements

    Science.gov (United States)

    Morman, Justyna

    2018-04-01

    The article presents the result of laboratory tests for mining waste with grain size of 0 to 2 mm stabilized with cement. Used for stabilization of cement CEM I 42.5 R and blast furnace cement CEM III / A 42.5N - LH / HSR / NA and a plasticizer sealant. Cement was added to the mining waste test in the proportions of 5 - 8% in relation to the skeleton's weight. For the cemented samples, the freeze resistance test, swelling index, coefficient of permeability and pH of water leachate were tested. The addition of a cement binder resulted in diminishing the water permeability of mining waste and limiting the leaching of fine particles from the material.

  8. High pulmonary vascular resistance in addition to low right ventricular stroke work index effectively predicts biventricular assist device requirement.

    Science.gov (United States)

    Imamura, Teruhiko; Kinugawa, Koichiro; Kinoshita, Osamu; Nawata, Kan; Ono, Minoru

    2016-03-01

    Although the right ventricular stroke work index (RVSWI) is a good index for RV function, a low RVSWI is not necessarily an indicator for the need for a right ventricular assist device at the time of left VAD implantation. We here aimed to determine a more precise indicator for the need for a biventricular assist device (BiVAD). In total, 116 patients (mean age, 38 ± 14 years), who underwent hemodynamic assessments preoperatively including 12 BiVAD patients, and had been followed at our institute from 2003 to 2015, were included. Multivariate logistic regression analysis indicated that RVSWI and pulmonary vascular resistance (PVR) were independent predictors of BiVAD requirement (P 5 g/m, PVR 5, PVR > 3.7), (3) RV failure (RVSWI 3.7), and examined. Most of the patients in Group 4 (75 %), with acutely depressed hemodynamics and inflammatory responses in the myocardium, required BiVAD. Overall, patients with BiVAD had a worse survival rate as compared with those with LVAD alone. In conclusion, high PVR in addition to low RVSWI effectively predicts BiVAD requirement.

  9. Assessment of the fatty liver index as an indicator of hepatic steatosis for predicting incident diabetes independently of insulin resistance in a Korean population.

    Science.gov (United States)

    Jung, C H; Lee, W J; Hwang, J Y; Yu, J H; Shin, M S; Lee, M J; Jang, J E; Leem, J; Park, J-Y; Kim, H-K

    2013-04-01

    Fatty liver disease, especially non-alcoholic fatty liver disease, is considered to be the hepatic manifestation of the metabolic syndrome, both closely associated with insulin resistance. Furthermore, fatty liver disease assessed by ultrasonography is known to be a predictor of the development of Type 2 diabetes mellitus. However, it remains unclear whether fatty liver disease plays a role in the pathogenesis of Type 2 diabetes independently of insulin resistance. In this study, we investigated whether fatty liver disease assessed by the fatty liver index can predict the development of Type 2 diabetes independently of systemic insulin resistance. We examined the clinical and laboratory data of 7860 subjects without diabetes who underwent general routine health evaluations at the Asan Medical Center in 2007 and had returned for follow-up examinations in 2011. Fatty liver index was calculated using an equation that considers serum triglyceride levels, γ-glutamyltransferase, waist circumference and BMI. During a 4-year period, 457 incident diabetes cases (5.8%) were identified. The odds ratios for the development of Type 2 diabetes were significantly higher in the group with a fatty liver index ≥ 60 (fatty liver index-positive) than in the group with a fatty liver index hepatic steatosis is valuable in identifying subjects at high risk for Type 2 diabetes. In addition, fatty liver disease itself contributes to the development of Type 2 diabetes independently of systemic insulin resistance. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.

  10. Reasoning and representation in RiTSE

    International Nuclear Information System (INIS)

    Epstein, S.A.

    1987-01-01

    RiTSE, the Reactor Trip Simulation Environment, is a frame and rule-base artificial intelligence (AI) application which aids nuclear power plant operators in determining if a proposed change in a state of a component or process causes safety systems to automatically shut the plant down. This paper stresses the software techniques used to implement the system. The authors demonstrate that prototypes and industrial strength systems can be built quickly and economically without expert system shells, and that integration of AI and database techniques create a novel programming paradigm

  11. Corneal refractive index-hydration relationship by objective refractometry.

    Science.gov (United States)

    Patel, Sudi; Alió, Jorge L

    2012-11-01

    To compare an objective (VCH-1) with a manual subjective Abbé refractometer (MSAR) and evaluate the refractive index (RI)-hydration (H) relationship for the corneal stroma. Epithelial and endothelial layers were removed from a fresh postmortem ovine corneal buttons. RI was measured at both surfaces using (i) MSAR then (ii) VCH-1. The sample was weighed, slowly dehydrated under controlled conditions (2 h), and RI measures were repeated. Sample was oven dried (90°C) for 3 d to obtain dry weight and hydration at each episode of RI measurement. Average difference between individual pairs of measurements obtained using the two refractometers (ΔRI) was 0.00071 (standard deviation ± 0.0029, 95% confidence interval ± 0.0058). Root mean square difference between measurements obtained by the refractometers was 0.0024. There was no relationship between ΔRI and the mean of each measurement pair (r = 0.201, n = 40, p = 0.214). Linear regression revealed a significant relationship between RI and reciprocal of H at both surfaces as follows: anterior (i) RI = 1.355 + 0.111/H (r = -0.852, n = 20, p = <0.001), (ii) RI = 1.357 + 0.105/H (r = -0.849, n = 20, p = <0.001) and posterior (i) RI = 1.353 + 0.085/H (r = -0.882, n = 20, p = <0.001), (ii) RI = 1.350 + 0.088/H (r = -0.813, n = 20, p = <0.001). VCH-1 measurements are in good agreement with MSAR. RI at the anterior stroma was consistently higher suggesting hydration is lower by 1.10 units (6%) compared with the posterior stroma. Dehydration increased RI at both surfaces by similar rates. Current hypothetical models are useful for predicting RI from H for the posterior, but not the anterior, stroma.

  12. ri Talveti luulepiiriületamised / Jüri Talvet ; intervjueerinud Rein Veidemann

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2010-01-01

    IX Moncayo luulefestivalist Aragoonias 10. aug. 2010 ja Jüri Talveti luule tõlgetest: Del sueno, de la nieve / tõlkinud Albert Lázaro Tinaut (Olifante, 2010) ; Of Snow, of Soul / tõlkinud H. L. Hix (Guernica, 2010)

  13. Prevalence of the metabolic syndrome, insulin resistance index, leptin and thyroid hormone levels in the general population of Merida (Venezuela).

    Science.gov (United States)

    Uzcátegui, Euderruh; Valery, Lenin; Uzcátegui, Lilia; Gómez Pérez, Roald; Marquina, David; Baptista, Trino

    2015-06-01

    The metabolic syndrome (MetSyn) is a significant risk factor for cardiovascular events, but scarce information exists about its frequency in Venezuela. In this cross-sectional study, we quantified the prevalence of the MetSyn in a probabilistic, stratified sample of 274 subjects aged > or =18 years from the Libertador district in Merida, Venezuela. Secondary outcomes were the measurement of thyroid hormones (free T4 and TSH), leptin levels, and insulin resistance index (HOMA2-IR). The frequency of MetSyn (percentage +/- 95% confidence interval) according to several diagnostic criteria was as follows: National Cholesterol Education Panel (NCEP, original): 27.4% (22.1-32.7); modified NCEP: 31.8% (26.3-37.3); International Diabetes Federation: 40.9% (35.1-46.7); Latin American Diabetes Association: 27% (21.7-32.3), and Venezuelan criteria: 31.8% (26.3-37.3). The MetSyn was more frequent in males than in females with most diagnostic criteria. The estimated prevalence of type 2 diabetes mellitus was 2.9% either according to the patients' self reports or to fasting glucose level found to be above 126 mg/dL. Abnormal HOMA2-IR index, free T4 and TSH (above the 95th percentile) were detected in 4.5%, 4.4% and 5.1% of the sample, respectively. Free T4 and TSH levels below the 5th percentile were detected in 4.4% and 4.7% of subjects respectively. These values are presented for comparisons with forthcoming studies in specific clinical populations. While studies are being conducted about the different definitions of the MetSyn in Venezuela, we recommend analyzing and publishing local research data with all the available criteria so as to allow comparisons with the results already reported in the literature.

  14. Change in body mass index and insulin resistance after 1-year treatment with gonadotropin-releasing hormone agonists in girls with central precocious puberty.

    Science.gov (United States)

    Park, Jina; Kim, Jae Hyun

    2017-03-01

    Gonadotropin-releasing hormone agonist (GnRHa) is used as a therapeutic agent for central precocious puberty (CPP); however, increased obesity may subsequently occur. This study compared body mass index (BMI) and insulin resistance during the first year of GnRHa treatment for CPP. Patient group included 83 girls (aged 7.0-8.9 years) with developed breasts and a peak luteinizing hormone level of ≥5 IU/L after GnRH stimulation. Control group included 48 prepubertal girls. BMI and insulin resistance-related indices (homeostasis model assessment of insulin resistance [HOMA-IR] and quantitative insulin sensitivity check index [QUICKI]) were used to compare the groups before treatment, and among the patient group before and after GnRHa treatment. No statistical difference in BMI z -score was detected between the 2 groups before treatment. Fasting insulin and HOMA-IR were increased in the patient group; fasting glucose-to-insulin ratio and QUICKI were increased in the control group (all P resistance compared to the control group. During GnRHa treatment, normal-weight individuals showed increased BMI z -scores without increased insulin resistance; the overweight group demonstrated increased insulin resistance without significantly altered BMI z -scores. Long-term follow-up of BMI and insulin resistance changes in patients with CPP is required.

  15. Intra and interobserver variability of renal allograft ultrasound volume and resistive index measurements; Variabilita' intra- ed interoperatore delle misure ecografiche del volume e dell'indice di resistenza del rene trapiantato

    Energy Technology Data Exchange (ETDEWEB)

    Mancini, Marcello; Liuzzi, Raffaele [CNR, Napoli (Italy). Istituto di biostrutture e bioimmagini; Daniele, Stefania; Raffio, Teresa; Salvatore, Marco [Napoli Univ., Napoli (Italy). Dipartimento di diagnostica per immagini; Sabbatini, Massimo; Cianciaruso, Bruno [Napoli Univ., Napoli (Italy). Istituto di nefrologia medica; Ferrara, Liberato Aldo [Napoli Univ., Napoli (Italy). Dipartimento di medicina clinica e sperimentale

    2005-04-01

    Purpose: Aim of the presents study was to evaluate the repeatability and reproducibility of the Doppler Resistive Index (R.I.) and the Ultrasound renal volume measurement in renal transplants. Materials and methods: Twenty -six consecutive patients (18 men, 8 women) mean age of 42,8{+-}12,4 years (M{+-}SD)(range 22-65 years) were studied twice by each of two trained sonographers using a color Doppler ultrasound scanner. Twelve of them had a normal allograft function (defined as stable serum creatinine levels {<=}123,76 {mu}mol/L), whilst the remaining 14 had decreased allograft function (serum creatinine 132.6-265.2 {mu}mol/L). Results were given as mean of 6 measurements performed at upper, middle and lower pole of the kidney. Intra- and interobserver variability was assessed by the repeatability coefficient and coefficient of variation (CV). Results: Regarding Resistive Index measurement, repeatability coefficient was between 0.04 and 0.06 and the coefficient of variation was <5%. The analysis of the Student's test did not show any significant difference between the measurements (t=0.15; p=0.87 n.s.). A good reproducibility was also detected in US measurements of renal length and volume. Conclusions: These results suggest that Color Doppler Resistive Index measurements of renal allograft and Ultrasound renal volume measurements are repeatable and reproducible. [Italian] Scopo: Valutare la ripetibilit� e la riproducibilit� delle misurazioni ecografiche dell'Indice di Resistenza (I.R.) e del volume del rene trapiantato. Materiale e metodi: Ventisei pazienti (18 uomini, 8 donne) con et� media di 42,8{+-}12,4 anni (M{+-}SD)(range 22-65 anni) sono stati studiati consecutivamente due volte con eco-color-Doppler da due ecografisti esperti. Dodici pazienti avevano funzione renale normale (livello serico di creatina stabilmente {<=}123,76 {mu}mol/L, i rimanenti 14 avevano una lieve e stabile disfunzione del rene trapiantato (creatina serica 132.6-265.2 {mu

  16. Effect of Qianggan capsules on insulin resistance index and liver fibrosis score in patients with nonalcoholic fatty liver disease

    Directory of Open Access Journals (Sweden)

    OU Qiang

    2016-10-01

    Full Text Available Objective To investigate the effect of Qianggan capsules on liver fibrosis score and insulin resistance index in patients with nonalcoholic fatty liver disease (NAFLD. Methods A total of 85 NAFLD patients who were treated in the Eighth People′s Hospital of Shanghai from August 2014 to July 2015 were enrolled and randomly divided into treatment group (45 patients and control group (40 patients. The patients in the treatment group were given Qianggan capsules, and those in the control group were given polyene phosphatidylcholine capsules. The course of treatment was 24 weeks for both groups. The changes in serum aminotransferases [aspartate aminotransferase (AST and alanine aminotransferase (ALT], homeostasis model assessment of insulin resistance (HOMA-IR, and NAFLD fibrosis score (NAFLDFS after treatment were observed in both groups. The t-test was used for comparison of continuous data between groups, before-after comparison within each group was made by paired t-test; and the chi-square test was used for comparison of categorical data between groups. Results Both groups showed significant improvements in ALT and AST levels after treatment (all P<0.01. After treatment the treatment group showed significant reductions in HOMA-IR and NAFLDFS (3.58±0.85 vs 2.48±078,t=6.40,P<0.01; -1.78±1.24 vs -2.35±0.98,t=2.40,P<0.01 and the treatment group had significantly lower HOMA-IR and NAFLDFS than the control group(12.48±0.78 vs 3.09±0.89, t=3.36, P<0.01; -2.35±0.98 vs -1.48±1.08, t=3.80, P<0.01. No serious adverse events were observed during the course of treatment. Conclusion Qianggan capsules not only reduce the levels of serum aminotransferases, but also improve insulin resistance and reduce fibrosis degree in NAFLD patients.

  17. Levels of natural resistance to Boophilus microplus (Acari: Ixodidae in Carora breed bulls

    Directory of Open Access Journals (Sweden)

    Roy D. Meléndez

    1998-09-01

    Full Text Available Boophilus microplus infestation is one of the most serious limitations to cattle industry in tropical regions, even though bovines show natural resistance to ticks. This resistance was evaluated in Cross-bred Carora Bulls (CCB a tropicalized dairy breed from Venezuela. Seven CCB were experimentally infested with B. microplus larvae, "Mozo" strain, they were considered tick-naive because they had never been infested with ticks. The mean inoculum size applied on each bull was 6 477 larvae. After life cycle was completed adult female body weight (BW, egg mass weight (EW, egg hatching rate (%EH, and reproductive index (RI were recorded. Results revealed a high variability in the levels of resistance to B. microplus. Thus, one animal showed greater resistance (Dunnett, p< 0.05 for the analyzed parameters in contrast with three non-resistant bulls. The others had moderate resistance. The trait "resistance" should be included togheter with other traits often used in genetic selection of cattle.

  18. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes.

    Science.gov (United States)

    Lee, Eun Young; Yang, Hae Kyung; Lee, Joonyub; Kang, Borami; Yang, Yeoree; Lee, Seung-Hwan; Ko, Seung-Hyun; Ahn, Yu-Bae; Cha, Bong Yun; Yoon, Kun-Ho; Cho, Jae Hyoung

    2016-09-15

    Insulin resistance is one of the most important contributing factors to cardiovascular disease. This study aimed to investigate the association between coronary artery stenosis (CAS) and triglyceride glucose index (TyG index), a simple insulin resistance marker, in asymptomatic subjects with type 2 diabetes. We recruited asymptomatic adults with type 2 diabetes but without previous history of coronary heart disease (n = 888). Significant CAS was defined as maximum intraluminal stenosis ≥70 % by coronary CT angiography. TyG index was calculated as log [fasting triglycerides (mg/dl) x fasting glucose (mg/dl)/2]. Mean age was 63.8 ± 9.5 and 58.9 % of the subjects were men. We analyzed the participants according to the tertile of TyG index. The TyG index was correlated with HOMA-IR (r = 0.397, P index were younger but showed worse clinical and metabolic parameters. The prevalence of CAS was higher in subjects with higher tertile of TyG compared with those with lower tertile of TyG (14 % vs. 7.8 %, P = 0.022). On multiple regression analysis, the highest tertile of TyG index was an independent risk factor for CAS after adjustment for other confounders (odds ratio, 3.19 [95 % CI, 1.371-7.424]). Subgroup analysis showed that TyG index showed more significant association with CAS in patients with risk factors such as old age, longer duration of diabetes, poor glycemic control, no statin use, and male gender. Higher TyG index is associated with increased risk of CAS in asymptomatic subjects with type 2 diabetes, particularly when they have risk factors for cardiovascular disease. This study was retrospectively registered in ClinicalTrials. gov with the registration number of NCT02070926 in Feb 23, 2014.

  19. Nuclear structure physics at RI beam factory

    International Nuclear Information System (INIS)

    Otsuka, Takaharu

    1998-01-01

    The nuclear structure physics is becoming extremely interesting owing to recent development of RI beam factories. Among various interesting developments in this field, I will focus upon two subjects. One is the breaking of the usual magic numbers in unstable nuclei, and the other is the invention of a new method for quantum many-body problems: Quantum Monte Carlo diagonalization method (QMCD). For the first subject, I will discuss the vanishing of N=8 and 20 magic numbers in 11 Li and 32 Mg, respectively. For the latter, I will present brief description of the theory and results of some applications including the one to 64 Ge, a proton-rich unstable nucleus. (author)

  20. ri Naela rahakotti prantsatas miljon krooni / Aigi Viira

    Index Scriptorium Estoniae

    Viira, Aigi

    2009-01-01

    Tallinna Ülikooli tantsukompositsiooni dotsent Jüri Nael sai Eesti haridus- ja teadusministeeriumilt miljonikroonise stipendiumi doktoriõpinguteks Londonis Royal Holloway University's. Jüri Nael pühendub Londonis õppides sellele, mis jääb teatri ja tantsu vahele ehk füüsilisele teatrile, täpsemalt – füüsilisele eksperimentaalteatrile

  1. Spallation RI beam facility and heavy element nuclear chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Nagame, Yuichiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-11-01

    An outline of the spallation RI (Radioactive Ion) beam facility is presented. Neutron-rich nuclides are produced in the reaction of high intensity (10-1000 {mu}A) protons with energy of 1.5 GeV and an uranium carbide target. Produced nuclides are ionized in an isotope separator on-line (ISOL) and accelerated by the JAERI tandem and the booster linac. Current progress and a future project on the development of the RI beam facility are given. Studies of transactinide elements, including the synthesis of superheavy elements, nuclear structure far from stability, and RI-probed material science are planned with RI beams. An outlook of the transactinide nuclear chemistry studies using neutron-rich RI beams is described. (author)

  2. Üksikud naljakad peaaegu kolmikud / Jüri Viikberg ; tlk. Jüri Viikberg

    Index Scriptorium Estoniae

    Viikberg, Jüri 1953-

    2005-01-01

    Arvustus: Punttila, Matti. Haaskannäköinen tyttö : kielikaskuista sanaleikkeihin. Helsinki, 1998 ; Punttila, Matti. Pilkettä silmäkulmaan : kielikaskuista sanaleikkeihin. Helsinki, 2001 ; Punttila, Matti. Poskettomia huulia : kielikaskuista sanaleikkeihin. Helsinki, 2004. Näiteid: Kui keel ei püsi hammaste taga ; Sõna keeles ja keel hammaste vahel / tõlkinud Jüri Viikberg // Oma Keel, 1995, nr. 1, lk. 55-56, 63-64

  3. Näitus "Sajand eesti puugravüüri klotsidel" / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2007-01-01

    Eesti Rahvusraamatukogus 15. I-3. II eksponeeritud ja rahvusraamatukogu kollektsioonist koostatud näitusest "Sajand eesti puugravüüri klotsidel: 1840-1940". Järgmistest kunstnikest ja nende töödest: Aleksander Otto Gern, Bogdan Gottlieb Friedrich Kally, August Daugell, Hermann Eduard Hartmann, Eduard Magnus Jakobson, Mart Pukits, Andres Kuusk, Karl Friedrich Schnell, Anton Suurkask (1873-1965), Arkadio Laigo, Hando Mugasto, Eduard Järv, Richard Kaljo, Ott Kangilaski, Ants Puks (1918-?), Salome Trei

  4. Application of RI-counting method for posttraumatic CSF rhinorrhea

    International Nuclear Information System (INIS)

    Itoh, Takahiko; Terai, Yoshinori; Fujimoto, Shunichiro; Kawauchi, Masamitsu.

    1987-01-01

    Numerous techniques and procedures have been reported for the evaluation of CSF fistulas. Especially metrizamide CT cisternography and radioisotope (RI) cisternography have been reported to be reliable for localizing the site of CSF leakage, however, it has been difficult to diagnose the existence and the site of CSF leakages in some cases. RI-counting method, measuring RI-count of intranasal cotton pledgets after the intrathecal injection of RI ( 111 In-DTPA) is thought to be the most reliable method for detecting the presence of CSF leakage in these cases. We used six cotton pledgets which were inserted into upper, middle, and lower meatuses on both side. Because the site of pledgets with ghest RI-count has anatomical relationship to the opening of the paranasal sinus, we can surmise the leakage of dural defect and CSF leakage. RI counting method was applied to two patients in whom it was difficult to diagnose the presence of CSF leakage with other procedures. The patients were free in position for four hours after the intrathecal injection of RI, and in the prone position for 30 minutes before RI-counting of intranasal cotton pledgets. After measuring the RI-counts of six pledgets, the counts were compared with each other. The cotton pledget inserted into left middle meatus showed the highest count in both cases. From this result and finding of conventional skull tomography we speculated the site of CSF leakage to be frontal sinus or ethmoid sinus. Operation demonstrated the opening of dura into the frontal sinus in one case, and ethmoid sinus in another case. As mentioned above, RI-counting method has the advantages of detecting the existence and the site of CSF leakage. (author)

  5. 75 FR 15343 - Regulated Navigation Area: Narragansett Bay, RI and Mount Hope Bay, RI and MA, Including the...

    Science.gov (United States)

    2010-03-29

    ...: Narragansett Bay, RI and Mount Hope Bay, RI and MA, Including the Providence River and Taunton River AGENCY... River and Mount Hope Bay in the vicinity of the two Brightman Street bridges have not been adopted and... Island and Mt. Hope Bay, MA.'' The notice was prompted primarily by two events: (1) The U.S. Army Corps...

  6. The RiSE climbing robot: body and leg design

    Science.gov (United States)

    Saunders, A.; Goldman, D. I.; Full, R. J.; Buehler, M.

    2006-05-01

    The RiSE robot is a biologically inspired, six legged climbing robot, designed for general mobility in scansorial (vertical walls, horizontal ledges, ground level) environments. It exhibits ground reaction forces that are similar to animal climbers and does not rely on suction, magnets or other surface-dependent specializations to achieve adhesion and shear force. We describe RiSE's body and leg design as well as its electromechanical, communications and computational infrastructure. We review design iterations that enable RiSE to climb 90° carpeted, cork covered and (a growing range of) stucco surfaces in the quasi-static regime.

  7. Shielding design of RIKEN RI Beam Factory

    Energy Technology Data Exchange (ETDEWEB)

    Uwamino, Yoshitomo; Fukunishi, Nobuhisa [Institute of Physical and Chemical Research, Wako, Saitama (Japan); Oishi, Koji [Shimizu Corp., Tokyo (Japan)

    2000-03-01

    Construction of the RIKEN RI Beam Factory is started, and the phase 1 will be finished by the end of March 2003. Two ring cyclotrons including one superconducting machine and two Big RIPSs will be constructed in the phase 1. Heavy ions of proton to uranium will be accelerated up to 400 MeV/u (A<40) and 150 MeV/u for uranium at an intensity of 10{sup 13} pps. Neutron production by the 400 MeV/u {sup 20}Ne beam was measured at HIMAC of NIRS and it was used for the source term of the shielding calculations. The deep penetration of high-energy neutrons was calculated by using the ANISN code with the DLC-119/HILO86R group constants and also by using the HETC code. The ANISN results were modified by using the HETC results and the shielding experiment at ISIS, and they were fitted by a simple formula for practical use. High-energy neutron penetrations of slantwise injection and the reflection probabilities of iron slab were calculated with the HETC code, and these results were used for the estimation of the thickness for the iron local shielding of Big RIPSs. Induced radioactivity in the air, accelerator components and the building, and the skyshine effect were also estimated. (author)

  8. Pilates versus resistance exercise on the serum levels of hs-CRP, in the abdominal circumference and body mass index (BMI) in elderly individuals

    OpenAIRE

    Pestana, Maria Dida Silva; Netto, Eduardo Martins; Pestana, Manuella Castro Silva; Pestana, Vitor Silva; Schinoni, Maria Isabel

    2016-01-01

    Recent studies have shown that the elderly exhibit a subclinical state of inflammation associated with increased adipose tissue and several comorbidities. To compare the effects of mat Pilates based exercises and resistance exercise on the serum levels of reactive C protein of high sensitivity (hs-CRP), in the abdominal circumference (AC) and the body mass index (BMI) in the elderly. It is a randomised clinical trial with a sample of 78 elderly individuals (median age 69 years). The active in...

  9. Investigation of glyphosate resistance levels and target-site based resistance (TSR) mechanisms in Conyza canadensis (L.) from apple orchards around areas of Bohai seas and Loess Plateau in China.

    Science.gov (United States)

    Mei, Yu; Xu, Yufang; Wang, Shipeng; Qiu, Lihong; Zheng, Mingqi

    2018-04-01

    The resistance levels to glyphosate and target-site based resistance mechanisms in susceptible (S) and resistant (R) Conyza canadensis (L.) populations, which were collected from apple orchards around areas of Bohai seas and Loess Plateau in China, were investigated. Among forty C. canadensis populations, eighteen populations (45%) were still susceptible; fourteen populations (35%) evolved low resistance levels resistance to glyphosate with resistance index (RI) of 2.02 to 3.90. In contrast, eight populations (20%) evolved medium resistance levels with RI of 4.35 to 8.38. The shikimic acid concentrations in R populations were highly negative relative with the glyphosate resistance levels in C. canadensis, the Pearson correlation coefficient was -0.82 treated by glyphosate at 1.8mg/L. Three 5-enoylpyruvylshikimate 3'-phosphate synthase genes (EPSPS1, EPSPS2 and EPSPS3) were cloned in all S and glyphosate-resistant C. canadensis populations. No amino acid substitution was identified at site of 102 and 106 in three EPSPS genes, which were reported to confer glyphosate resistance in other weed species. The relative expression level of EPSPS mRNA in R populations (SD07, LN05, SHX06 and SD09) was 4.5 to 13.2 times higher than in S biotype. The Pearson correlation coefficient between EPSPS expression levels and RI was 0.79, which indicated the over expression of EPSPS mRNA may cause these R populations evolve higher resistance level to glyphosate. Copyright © 2018 Elsevier Inc. All rights reserved.

  10. Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance.

    Science.gov (United States)

    Du, Tingting; Yuan, Gang; Zhang, Muxun; Zhou, Xinrong; Sun, Xingxing; Yu, Xuefeng

    2014-10-20

    To directly compare traditional lipid ratios (total cholesterol [TC]/high density lipoprotein cholesterol [HDL-C], non-HDL-C/HDL-C, low density lipoprotein cholesterol [LDL-C]/HDL-C, and triglycerides [TG]/HDL-C), apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio, visceral adiposity index (VAI), lipid accumulation product (LAP), and the product of TG and fasting glucose (TyG) for strength and independence as risk factors for insulin resistance (IR). We conducted a cross-sectional analysis of 7629 Chinese adults using data from the China Health and Nutrition Survey 2009. For all lipid ratios (traditional lipid ratios and apoB/apoA-I), among both sexes, TG/HDL-C explained the most additional percentage of variation in HOMA-IR (2.9% in men, and 2.3% in women); for all variables of interest, the variability in HOMA-IR explained by VAI and TG/HDL-C were comparable; TyG had the most significant association with HOMA-IR, which explained 9.1% for men and 7.8% for women of the variability in HOMA-IR. Logistic regression analysis showed the similar patterns. Receiver operating characteristic (ROC) curve analysis showed that, among both sexes, TG/HDL-C was a better discriminator of IR than apoB/apoA-I; the area under the ROC curve (AUC) for VAI (0.695 in men and 0.682 in women) was greater than that for TG/HDL-C (AUC 0.665 in men and 0.664 in women); TyG presented the greatest value of AUC (0.709 in men and 0.711 in women). The apoB/apoA-I performs no better than any of the traditional lipid ratios in correlating with IR. The TG/HDL-C, VAI and TyG are better markers for early identification of IR individuals.

  11. G-index: A new metric to describe dynamic refractive index effects in HPLC absorbance detection.

    Science.gov (United States)

    Kraiczek, Karsten G; Rozing, Gerard P; Zengerle, Roland

    2018-09-01

    High performance liquid chromatography (HPLC) with a solvent gradient and absorbance detection is one of the most widely used methods in analytical chemistry. The observed absorbance baseline is affected by the changes in the refractive index (RI) of the mobile phase. Near the limited of detection, this complicates peak quantitation. The general aspects of these RI-induced apparent absorbance effects are discussed. Two different detectors with fundamentally different optics and flow cell concepts, a variable-wavelength detector equipped with a conventional flow cell and a diode-array detector equipped with a liquid core waveguide flow cell, are compared with respect to their RI behavior. A simple method to separate static - partly unavoidable - RI effects from dynamic RI effects is presented. It is shown that the dynamic RI behavior of an absorbance detector can be well described using a single, relatively easy-to-determine metric called the G-index. The G-index is typically in the order of a few seconds and its sign depends on the optical flow cell concept. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. Literature as a nation's emotional memory / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1998-01-01

    Bibliograafia, lk. 134-135. Autorist lk. 387. Juri Lotmani semiosfääri tõlgendamisest: "süntagmaatilised" struktuurid ja "perifeersed" kultuurid. Ka Friedebert Tuglase "Kalevipoja"-kriitikast ning Lydia Koidula ja Juhan Liivi luuletustest

  13. Ühest avastamata illustreeritud raamatust / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2011-01-01

    Erick, Françoise. Heute / ill. Sergei Slastnikov. Tallinn : Tallinna Eesti Kirjastus-Ühisus, 1926. S. Slastnikovi puugravüüris illustratsioonidest, tema kunstialastest kirjutistest ja puugravüüri kasutuselevõtust eesti raamatukunstis

  14. Helilooja Jüri Dmitrievi loominguline õhtu / Vladislav Horuzhenko

    Index Scriptorium Estoniae

    Horuzhenko, Vladislav

    2006-01-01

    Viiuldajast, pianistist ja heliloojast Jüri Dmitrievist. Loomingulisest õhtust 8. okt. Pärnu raekojas Pärnumaa Rahvakultuuri Keskseltsi korraldatava projekti "Inimesed Pärnumaa kultuurimaastikul" raames

  15. [Mihai Eminescu luulefestivalil osales Jüri Talvet

    Index Scriptorium Estoniae

    2014-01-01

    Mihai Eminescu luulefestivalil esitleti mahukat tõlkeantoloogiat "Antologia poeziei universal de astăzi" (Craiova: Editura Europa”, 2014), mille on koostanud Ion Deaconescu. Antoloogias on ka Jüri Talveti luulet

  16. President vabastas Jüri Sakkarti kohtuniku ametist / Tanel Mazur

    Index Scriptorium Estoniae

    Mazur, Tanel, 1971-

    2010-01-01

    President Toomas Hendrik Ilves kirjutas 9. veebruaril 2010 alla otsusele vabastada Jüri Sakkart Viru Maakohtu kohtuniku ametist tema enda soovil. Kaitsepolitsei on J. Sakkarti kuriteokahtlustusega kinni pidanud

  17. Pealinlased olid aktiivsemad valijad / Jüri Ratas

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2007-01-01

    Ilmunud ka: Stolitsa, 14. märts 2007, lk. 2. Tallinna linnapea Jüri Ratas parlamendivalimiste tulemustest. Vt. samas: Kes Tallinnast riigikokku valiti?; Riigikogu valimise tulemused Tallinnas: diagramm

  18. Narragansett, RI Lab--Office of Research and Development

    Science.gov (United States)

    The EPA-ORD laboratory in Narragansett, RI is a recognized leader in scientific knowledge and expertise concerning the ecology of oceans, estuaries, and water-sheds, and the effects of human activities on that ecology.

  19. Szathmári, a great documentary artist

    Directory of Open Access Journals (Sweden)

    Ionescu, Adrian-Silvan

    2014-01-01

    Full Text Available Carol Pop de Szathmári was born in Cluj, Transylvania, on 11 January 1812. His talent for painting shone out from an early age. Being a passionate traveller, Szathmári journeyed through Europe and often crossed the Carpathian Mountains to visit Wallachia and its capital, Bucharest, where he eventually settled in 1843. An accomplished landscape and portrait painter, at ease with both watercolours and oil paints, Szathmári obtained commissions from the wealthy Wallachian boyars. Szathmári kept up constant, good relations with the successive ruling princes of Wallachia for whom he painted portraits and various other compositions. By 1848, Szathmári began to experiment with photography. The outbreak of the Russian-Ottoman War in late June 1853 saw the Romanian principalities occupied by the Russian army. In April 1854, Szathmári filled a van with his cameras and glass plates and went to the Danube to document the fighting between the Russian and Turkish armies.The result of Szathmári's bravery and hard work was a photographic album. His album, containing some two hundred images, became famous due to its presentation at the 1855 Paris World's Fair and Szathmári was awarded the Second Class Medal for his work.From that time on, photography, painting and lithography were always closely connected in Szathmári's career. In 1864 he became a member of the Société Française de Photographie in Paris and in 1870 of the one in Vienna. In 1863, he was appointed Court Painter and Photographer, a position he held for the rest of his life. In that capacity, he followed his patron, Prince Carol I, on the battlefield during the Russian-Romanian-Ottoman War of 1877, which was waged south of the Danube. Alongside martial compositions and albums, Szathmári had long been attracted by folk types and produced a large series of pictures of peasants, gypsies, postillions, merchants and artisans. He toured the fairs and the crowded streets of the town in search

  20. Value of Resistive lndex of the lntrascrotal Artery in ScrotaI Inflammatory Disease

    International Nuclear Information System (INIS)

    Jee, Won Hee; Yoon, Yeo Dong; Hwang, Sung Su; Choi, Byung Gil; Son, Kyung Myung; Lee, Sung Yong; Kim, Ki Tae; Shinn, Kyung Sub

    1995-01-01

    This prospective study was designed to investigate the utility of resistive indices(RIs) of intratesticular and epididymal arteries in inflammatory scrotal disease. Gray-scale and color Doppler ultrasonographic images were obtained in 19 consecutive patients of scrotal inflammatory disease from Nov.1993 to Oct. 1994. Eleven cases of epididymitis and 11 of epididymoorchitis(EO) were included. RIs of epididymal and centripetal arteries were calculated in 19 patients and 30 cases of control. All EO and epididymitis cases showed increased color signal at color Doppler ultrasonogram at representative sites. Mean RI of centripetal artery was 0.46±0.06 in EO and 0.66±0.07 in normal control, hence RI in EO was significantly lower than that of normal control(P<0.001). The diagnostic sensitivity was 91% when the value of 0.5 or less is estimated abnormal.Mean RI of centripetal artery was 0.67±0.07 in epididymitis, and was not significantly different from that of normal control(P=0.687). Mean RI of epididymal artery in epididymitis and EO was 0.48±0.12 and resistive index of all patients were below 0.7. Color Doppler can demonstrate the hyperemic response to scrotal inflammatory disease that it can supplement the gray scale finding leading to increased diagnostic confidence. RI of centripetal artery may be confirmative in the diagnosis of inflammatory scrotal inflammatory scrotal diseases when increased color flow on color flow imaging is present

  1. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

    NARCIS (Netherlands)

    Manning, Alisa K.; Hivert, Marie-France; Scott, Robert A.; Grimsby, Jonna L.; Bouatia-Naji, Nabila; Chen, Han; Rybin, Denis; Liu, Ching-Ti; Bielak, Lawrence F.; Prokopenko, Inga; Amin, Najaf; Barnes, Daniel; Cadby, Gemma; Hottenga, Jouke-Jan; Ingelsson, Erik; Jackson, Anne U.; Johnson, Toby; Kanoni, Stavroula; Ladenvall, Claes; Lagou, Vasiliki; Lahti, Jari; Lecoeur, Cecile; Liu, Yongmei; Martinez-Larrad, Maria Teresa; Montasser, May E.; Navarro, Pau; Perry, John R. B.; Rasmussen-Torvik, Laura J.; Salo, Perttu; Sattar, Naveed; Shungin, Dmitry; Strawbridge, Rona J.; Tanaka, Toshiko; van Duijn, Cornelia M.; An, Ping; de Andrade, Mariza; Andrews, Jeanette S.; Aspelund, Thor; Atalay, Mustafa; Aulchenko, Yurii; Balkau, Beverley; Bandinelli, Stefania; Beckmann, Jacques S.; Beilby, John P.; Bellis, Claire; Bergman, Richard N.; Blangero, John; Boban, Mladen; Kumari, Meena; Penninx, Brenda

    Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and beta-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance

  2. Combined use of serum MCP-1/IL-10 ratio and uterine artery Doppler index significantly improves the prediction of preeclampsia.

    Science.gov (United States)

    Cui, Shihong; Gao, Yanan; Zhang, Linlin; Wang, Yuan; Zhang, Lindong; Liu, Pingping; Liu, Ling; Chen, Juan

    2017-10-01

    Monocyte chemotactic protein-1 (MCP-1, or CCL2) is a member of the chemokine subfamily involved in recruitment of monocytes in inflammatory tissues. IL-10 is a key regulator for maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the feto-maternal interface. Doppler examination has been routinely performed for the monitoring and management of preeclampsia patients. This study evaluates the efficiency of these factors alone, or in combination, for the predication of preeclampsia. The serum levels of MCP-1 and IL-10 in 78 preeclampsia patients and 143 age-matched normal controls were measured. The Doppler ultrasonography was performed and Artery Pulsatility Index (PI) and Resistance Index (RI) were calculated for the same subjects. It was found that while the second-trimester serum MCP-1, IL-10, MCP-1/IL-10 ratio, PI, and RI showed some power in predicting preeclampsia, the combination of MCP-1/IL-10 and PI and RI accomplishes the highest efficiency, achieving an AUC of 0.973 (95% CI, 0.000-1.000, Ppreeclampsia. Future studies using a larger sample can be conducted to construct an algorithm capable of quantitative assessment on the risk of preeclampsia. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. RI/MOM and RI/SMOM renormalization of overlap quark bilinears on domain wall fermion configurations

    Science.gov (United States)

    Bi, Yujiang; Cai, Hao; Chen, Ying; Gong, Ming; Liu, Keh-Fei; Liu, Zhaofeng; Yang, Yi-Bo; χ QCD Collaboration

    2018-05-01

    Renormalization constants (RCs) of overlap quark bilinear operators on 2 +1 -flavor domain wall fermion configurations are calculated by using the RI/MOM and RI/SMOM schemes. The scale independent RC for the axial vector current is computed by using a Ward identity. Then the RCs for the quark field and the vector, tensor, scalar, and pseudoscalar operators are calculated in both the RI/MOM and RI/SMOM schemes. The RCs are converted to the MS ¯ scheme and we compare the numerical results from using the two intermediate schemes. The lattice size is 4 83×96 and the inverse spacing 1 /a =1.730 (4 ) GeV .

  4. ri Lina kui tegelikkusele osutav Patagoonia šamaan / Jüri Lina ; intervjueerinud Ingrid Peek

    Index Scriptorium Estoniae

    Lina, Jüri, 1949-

    2011-01-01

    2.-5. juunini Tallinnas kinos Sõprus toimuva festivali "Hallo, Kosmos!" raames 2. juunil esilinastuvast Jüri Lina filmist "Täitmatu Uroboros. Massoonide salakaval taktika", tema uuringute põhjusest. Festivali "Hallo, Kosmos!" kavast

  5. Application of own computer program for assessment of brain-fluid index in the medial temporal lobe portions in patients with drug-resistant temporal lobe epilepsy

    International Nuclear Information System (INIS)

    Boguslawska, R.; Skrobowska, E.; Rysz, A.

    2009-01-01

    Background: Epilepsy resistant to pharmacological treatment still remains one of the main problems in contemporary epileptology. The problem most frequently concerns patients with focal epilepsy, with the seizure focus possible to localize. In case of drug-resistant epilepsy, both morphological imaging methods (MR) and manual measurements or volumetry are used. Also functional studies, such as MRS (magnetic resonance spectroscopy), fMRI (functional magnetic resonance), SPECT (single photon emission tomography) and PET (positron emission tomography) are performed. Material/Methods: The study presents application of own computer program based on the method of segmentation of the cerebrospinal fluid (CSF) and the brain tissue. The program calculates automatically the brain-fluin index in the hippocampal region. The material comprises the brain-fluin index results calculated with the presented program in comparison with the method of manual delineation in a group of 50 patients with drug-resistant temporal lobe epilepsy. The program is easy to use, it reads the MR data recorded in DICOM installed on a PC. Results: The brain-fluin index result (expressed as a decimal fraction) is calculated on the basis of 4 consecutive layers examined by MR (evaluating hippocampal structures) performed using SE sequence, and T2-weighted imaging in the frontal plane perpendicular to the long axis of the temporal lobes. The results obtained in epilepsy patients were compared with 24 control subjects. Conclusions: Detailed analysis of the obtained data allowed to conclude that precise hippocampal volume assessment can be obtained by combination of both methods, i.e. manual delineation and automatic calculation of brain-fluin index taking into consideration the total volume of cerebral structures. (authors)

  6. Evaluation of resistant starch, glycemic index and fortificants content of premix rice coated with various concentrations and types of edible coating materials

    Science.gov (United States)

    Yulianto, W. A.; Susiati, A. M.; Adhini, H. A. N.

    2018-01-01

    The incidence of diabetes in Indonesia has been increasing year by year. Diets with a low glycemic index and high resistant starch foods can assist diabetics in controlling their blood glucose levels. Diabetics are known to have micro-nutrient deficiencies of chromium, magnesium and vitamin D that can be overcome by consuming parboiled rice fortified by use of a coating method. The fortification of parboiled rice (premix rice) can be achieved by coating with HPMC (hydroxypropyl methyl cellulose), MC (methyl cellulose), CMC (carboxyl methyl cellulose), gum arabic and rice starch. This research aimed to evaluate the levels of resistant starch, glycemic index and fortificants of premix rice coated with different concentrations and types of edible coating materials. This research used completely randomized design, with treatments to the concentrations and the types of edible coating (HPMC, CMC, MC, gum arabic and rice starch). The concentrations of edible coating were 0.15%, 0.2% and 0.25% for cellulose derivative coatings; 25%, 30%, 35% for gum arabic and 2%, 3.5% and 5% for rice starch. This research shows that fortified premix rice coated with various concentrations and types of edible coating materials is high in resistant starch and has a low glycemic index. The coating treatment affects the levels of magnesium and vitamin D, but does not affect the levels of chromium in parboiled rice. The premix rice with a low glycemic index and high nutrient content (chromium, magnesium and vitamin D) was premix rice coated by CMC 0.25% and HPMC 0.25% with glycemic indeces of 39.34 and 38.50, respectively.

  7. The reaction index and positivity ratio revisited

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Andersen, Flemming

    2008-01-01

    BACKGROUND AND OBJECTIVES: Assessing the quality of patch test preparations continues to be a challenge. 2 parameters, the reaction index (RI) and positivity ratio (PR), have been proposed as quality indicators by the Information Network of Departments of Dermatology (IVDK). The value of these st......BACKGROUND AND OBJECTIVES: Assessing the quality of patch test preparations continues to be a challenge. 2 parameters, the reaction index (RI) and positivity ratio (PR), have been proposed as quality indicators by the Information Network of Departments of Dermatology (IVDK). The value...

  8. The incidence of metabolic syndrome in obese Czech children: the importance of early detection of insulin resistance using homeostatic indexes HOMA-IR and QUICKI.

    Science.gov (United States)

    Pastucha, D; Filipčíková, R; Horáková, D; Radová, L; Marinov, Z; Malinčíková, J; Kocvrlich, M; Horák, S; Bezdičková, M; Dobiáš, M

    2013-01-01

    Common alimentary obesity frequently occurs on a polygenic basis as a typical lifestyle disorder in the developed countries. It is associated with characteristic complex metabolic changes, which are the cornerstones for future metabolic syndrome development. The aims of our study were 1) to determine the incidence of metabolic syndrome (based on the diagnostic criteria defined by the International Diabetes Federation for children and adolescents) in Czech obese children, 2) to evaluate the incidence of insulin resistance according to HOMA-IR and QUICKI homeostatic indexes in obese children with and without metabolic syndrome, and 3) to consider the diagnostic value of these indexes for the early detection of metabolic syndrome in obese children. We therefore performed anthropometric and laboratory examinations to determine the incidence of metabolic syndrome and insulin resistance in the group of 274 children with obesity (128 boys and 146 girls) aged 9-17 years. Metabolic syndrome was found in 102 subjects (37 %). On the other hand, the presence of insulin resistance according to QUICKI HOMA-IR >3.16 in 53 % of obese subjects. This HOMA-IR limit was exceeded by 70 % children in the MS(+) group, but only by 43 % children in the MS(-) group (p<0.0001). However, a relatively high incidence of insulin resistance in obese children without metabolic syndrome raises a question whether the existing diagnostic criteria do not falsely exclude some cases of metabolic syndrome. On the basis of our results we suggest to pay a preventive attention also to obese children with insulin resistance even if they do not fulfill the actual diagnostic criteria for metabolic syndrome.

  9. Estimating Rate of Insulin Resistance in Patients with Preeclampsia Using HOMA-IR Index and Comparison with Nonpreeclampsia Pregnant Women

    OpenAIRE

    Abhari, Farideh Rezaei; Ghanbari Andarieh, Maryam; Farokhfar, Asadollah; Ahmady, Soleiman

    2014-01-01

    Women with preeclampsia, independent of obesity and glucose intolerance, exhibit insulin resistance during pregnancy. The purpose of the present study is to determine whether early diagnosis of insulin resistance during pregnancy can predict preeclampsia. Through a case-control study, 675 pregnant women were selected and their first trimester blood was taken. Their fasting blood glucose and insulin were also measured after diagnosis of preeclampsia by 20 weeks of pregnancy. Based on the exper...

  10. [Relationship between the triglyceride/high-density lipoprotein-cholesterol ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome].

    Science.gov (United States)

    Roa Barrios, Marlene; Arata-Bellabarba, Gabriela; Valeri, Lenin; Velázquez-Maldonado, Elsy

    2009-02-01

    To evaluate the relationship between the triglyceride/high density lipoprotein cholesterol (TG/HDL-c) ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome (PCOS). The present crosssectional study analyzed 62 women with PCOS and 48 healthy women (control group) aged 17- 35 years old. Body mass index (BMI), waist circumference (WC) and blood pressure were registered. Plasma concentrations of glucose, insulin, triglycerides, total cholesterol and HDL-c were measured. TheTG/HDL-c ratio, homeostasis model assessment for insulin resistance (HOMA(IR)) and quantitative insulin sensitivity check index (QUICKI) were calculated. Women with PCOS showed significantly higher values of the TG/HDL-c ratio and HOMA(IR), and a significantly lower QUICKI value. These differences were related to BMI and WC, with the highest values being observed in obese patients. The 50th percentile for the TG/HDL-c ratio was 3.64; the TG/cHDL ratio was positively correlated with BMI, WC and HOMA(IR) (r=0.48, pglucose > 100 mg/dl (10% vs 3%; ptriglycerides>150 mg/dl (55% vs 20%; p80 cm (82.3% vs 43.8%; pindexes (HOMA(IR), QUICKI). The TG/HDL-c ratio could be considered as a useful and practical method to identify an increased risk of cardiovascular disease in patients with PCOS.

  11. Relationship between adiponectin and hepatic fibrosis markers expressions as well as insulin resistance index in patients with non-alcoholic fatty liver disease

    International Nuclear Information System (INIS)

    Cui Jianhe; Pan Feng; Zhou Chuanwen; Ren Jianguo; Li Donghai

    2009-01-01

    Objective: To investigate the retationship between expressions of adiponectin and hepatic fibrosis markers as well as insulin resistance index in patients with non-alcoholic fatty liver disease. Methods: Serum adiponectin, type III pro-collagen (PCIII), hyaluronic acid (HA), type IV collagen (CIV), laminin levels (with ELISA) and insulin resistance index (IRI) (calculated from homeostasis model assessment) were determined in 46 patients with non-alcoholic fatty liver disease (NAFLD) and 46 controls. Results The serum adiponectin levels in patients with NAFLD were significantly lower than those in controls while the serum hepatic fibrosis markers (PCIII, HA, CIV, LN) levels and IRI were significantly higher than those in controls (P<0.05). IRI was significantly positively correlated with the hepatic fibrosis markers levels (P<0.05). Serum adiponectin levels were significantly negatively correlated with WHR, RMI, HOMA-IRI and levels of FRG, TG, FINS hepatic fibrosis markers (P<0.05 or P<0.01). Conclusion: Serum adiponectin levels were greatly reduced in patients with NAFLD, which might play important role in the increase of insulin resistance and development of hepatic fibrosis. (authors)

  12. 76 FR 50770 - Submission for Review: Financial Resources Questionnaire (RI 34-1, RI 34-17, and RI 34-18) and...

    Science.gov (United States)

    2011-08-16

    ... OFFICE OF PERSONNEL MANAGEMENT Submission for Review: Financial Resources Questionnaire (RI 34- 1...) 3206-0167, Financial Resources Questionnaire and Notice of Amount Due Because of Annuity Overpayment... techniques or other forms of information technology, e.g., permitting electronic submissions of responses...

  13. Estimating Rate of Insulin Resistance in Patients with Preeclampsia Using HOMA-IR Index and Comparison with Nonpreeclampsia Pregnant Women

    Directory of Open Access Journals (Sweden)

    Farideh Rezaei Abhari

    2014-01-01

    Full Text Available Women with preeclampsia, independent of obesity and glucose intolerance, exhibit insulin resistance during pregnancy. The purpose of the present study is to determine whether early diagnosis of insulin resistance during pregnancy can predict preeclampsia. Through a case-control study, 675 pregnant women were selected and their first trimester blood was taken. Their fasting blood glucose and insulin were also measured after diagnosis of preeclampsia by 20 weeks of pregnancy. Based on the experiments conducted on 675 women who were 20 weeks past their pregnancy, 375 cases with preeclampsia were selected and assigned to the case group. 35 other pregnant women were put in the control group. Diagnosis criteria for the participants included blood pressure above 140/90 and proteinuria above 300 mg or above +1. Both groups were matched according to age, parity, gestational age, and BMI. Homa-Irand rate of insulin resistance was calculated by HOMA-IR and patients were followed up. Homeostatic model assessments (HOMA-IR revealed that the average insulin resistance increased during pregnancy among both the case and control groups. There was a significant difference between insulin resistance of these two groups in both first trimester and third trimester and after developing preeclampsia (P < 0.001, P = 0.021. Insulin-resistance of the group with preeclampsia was higher in first trimester prior to diagnosis as well as the third trimester after diagnosis compared to natural pregnancy under similar conditions. Measurement of insulin resistance in first trimester may be useful in predicting the risk of preeclampsia.

  14. Estimating rate of insulin resistance in patients with preeclampsia using HOMA-IR index and comparison with nonpreeclampsia pregnant women.

    Science.gov (United States)

    Abhari, Farideh Rezaei; Ghanbari Andarieh, Maryam; Farokhfar, Asadollah; Ahmady, Soleiman

    2014-01-01

    Women with preeclampsia, independent of obesity and glucose intolerance, exhibit insulin resistance during pregnancy. The purpose of the present study is to determine whether early diagnosis of insulin resistance during pregnancy can predict preeclampsia. Through a case-control study, 675 pregnant women were selected and their first trimester blood was taken. Their fasting blood glucose and insulin were also measured after diagnosis of preeclampsia by 20 weeks of pregnancy. Based on the experiments conducted on 675 women who were 20 weeks past their pregnancy, 375 cases with preeclampsia were selected and assigned to the case group. 35 other pregnant women were put in the control group. Diagnosis criteria for the participants included blood pressure above 140/90 and proteinuria above 300 mg or above +1. Both groups were matched according to age, parity, gestational age, and BMI. Homa-Irand rate of insulin resistance was calculated by HOMA-IR and patients were followed up. Homeostatic model assessments (HOMA-IR) revealed that the average insulin resistance increased during pregnancy among both the case and control groups. There was a significant difference between insulin resistance of these two groups in both first trimester and third trimester and after developing preeclampsia (P < 0.001, P = 0.021). Insulin-resistance of the group with preeclampsia was higher in first trimester prior to diagnosis as well as the third trimester after diagnosis compared to natural pregnancy under similar conditions. Measurement of insulin resistance in first trimester may be useful in predicting the risk of preeclampsia.

  15. Riigi äriühingu juhtorgani liige: kas ametiisik või ärijuht? / Jüri Raidla, Toomas Vaher, Kristel Urke

    Index Scriptorium Estoniae

    Raidla, Jüri, 1957-

    2017-01-01

    Riigi äriühingu põhijoontest, riigi äriühingu juhtorgani liikme kohustustest ja nõuetest juhtorgani liikmetele. Riigi äriühingute juhtorganite liikmete pidamisest ametiisikuteks korruptsioonivastase seaduse § 2 lõike 1 ja karistusseadustiku § 288 lõike 1 mõttes. Sisaldab asjakohast kohtupraktikat

  16. The HOMA-Adiponectin (HOMA-AD) Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS)

    Science.gov (United States)

    Cassani, Roberta Soares Lara; Forti, Adriana Costa e; Pareja, José Carlos; Tambascia, Marcos Antonio; Geloneze, Bruno

    2016-01-01

    Background The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index. Objectives To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR index as a surrogate marker of IR in women, and to establish the cutoff value of the HOMA-AD. Subjects/Methods The Brazilian Metabolic Syndrome Study (BRAMS) is a cross-sectional multicenter survey. The data from 1,061 subjects met the desired criteria: 18–65 years old, BMI: 18.5–49.9 Kg/m² and without diabetes. The IR was assessed by the indexes HOMA1-IR and HOMA-AD (total sample) and by the hyperglycemic clamp (n = 49). Metabolic syndrome was defined using the IDF criteria. Results For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r = -0.64) compared with the HOMA1-IR (r = -0.56); p 0.05). The optimal cutoff identified for the HOMA-AD for the diagnosis of IR was 0.95. Conclusions The HOMA-AD index was demonstrated to be a useful surrogate marker for detecting IR among adult women and presented a similar performance compared with the HOMA1-IR index. These results may assist physicians and researchers in determining which method to use to evaluate IR in light of the available facilities. PMID:27490249

  17. The HOMA-Adiponectin (HOMA-AD) Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS).

    Science.gov (United States)

    Vilela, Brunna Sullara; Vasques, Ana Carolina Junqueira; Cassani, Roberta Soares Lara; Forti, Adriana Costa E; Pareja, José Carlos; Tambascia, Marcos Antonio; Geloneze, Bruno

    2016-01-01

    The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index. To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR index as a surrogate marker of IR in women, and to establish the cutoff value of the HOMA-AD. The Brazilian Metabolic Syndrome Study (BRAMS) is a cross-sectional multicenter survey. The data from 1,061 subjects met the desired criteria: 18-65 years old, BMI: 18.5-49.9 Kg/m² and without diabetes. The IR was assessed by the indexes HOMA1-IR and HOMA-AD (total sample) and by the hyperglycemic clamp (n = 49). Metabolic syndrome was defined using the IDF criteria. For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r = -0.64) compared with the HOMA1-IR (r = -0.56); p HOMA1-IR, the HOMA-AD showed higher values of the AUC for the identification of IR based on the clamp test (AUC: 0.844 vs. AUC: 0.804) and on the metabolic syndrome (AUC: 0.703 vs. AUC: 0.689), respectively; p HOMA-AD in comparison with the HOMA1-IR in the diagnosis of IR and metabolic syndrome (p > 0.05). The optimal cutoff identified for the HOMA-AD for the diagnosis of IR was 0.95. The HOMA-AD index was demonstrated to be a useful surrogate marker for detecting IR among adult women and presented a similar performance compared with the HOMA1-IR index. These results may assist physicians and researchers in determining which method to use to evaluate IR in light of the available facilities.

  18. The HOMA-Adiponectin (HOMA-AD Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS.

    Directory of Open Access Journals (Sweden)

    Brunna Sullara Vilela

    Full Text Available The major adverse consequences of obesity are associated with the development of insulin resistance (IR and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index.To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR index as a surrogate marker of IR in women, and to establish the cutoff value of the HOMA-AD.The Brazilian Metabolic Syndrome Study (BRAMS is a cross-sectional multicenter survey. The data from 1,061 subjects met the desired criteria: 18-65 years old, BMI: 18.5-49.9 Kg/m² and without diabetes. The IR was assessed by the indexes HOMA1-IR and HOMA-AD (total sample and by the hyperglycemic clamp (n = 49. Metabolic syndrome was defined using the IDF criteria.For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r = -0.64 compared with the HOMA1-IR (r = -0.56; p 0.05. The optimal cutoff identified for the HOMA-AD for the diagnosis of IR was 0.95.The HOMA-AD index was demonstrated to be a useful surrogate marker for detecting IR among adult women and presented a similar performance compared with the HOMA1-IR index. These results may assist physicians and researchers in determining which method to use to evaluate IR in light of the available facilities.

  19. Change in body mass index and insulin resistance after 1-year treatment with gonadotropin-releasing hormone agonists in girls with central precocious puberty

    Directory of Open Access Journals (Sweden)

    Jina Park

    2017-03-01

    Full Text Available PurposeGonadotropin-releasing hormone agonist (GnRHa is used as a therapeutic agent for central precocious puberty (CPP; however, increased obesity may subsequently occur. This study compared body mass index (BMI and insulin resistance during the first year of GnRHa treatment for CPP.MethodsPatient group included 83 girls (aged 7.0–8.9 years with developed breasts and a peak luteinizing hormone level of ≥5 IU/L after GnRH stimulation. Control group included 48 prepubertal girls. BMI and insulin resistance-related indices (homeostasis model assessment of insulin resistance [HOMA-IR] and quantitative insulin sensitivity check index [QUICKI] were used to compare the groups before treatment, and among the patient group before and after GnRHa treatment.ResultsNo statistical difference in BMI z-score was detected between the 2 groups before treatment. Fasting insulin and HOMA-IR were increased in the patient group; fasting glucose-to-insulin ratio and QUICKI were increased in the control group (all P<0.001. In normal-weight subjects in the patient group, BMI z-score was significantly increased during GnRHa treatment (−0.1±0.7 vs. 0.1±0.8, P<0.001, whereas HOMA-IR and QUICKI exhibited no differences. In overweight subjects in the patient group; BMI z-score and HOMA-IR were not significantly different, whereas QUICKI was significantly decreased during GnRHa treatment (0.35±0.03 vs. 0.33±0.02, P=0.044.ConclusionGirls with CPP exhibited increased insulin resistance compared to the control group. During GnRHa treatment, normal-weight individuals showed increased BMI z-scores without increased insulin resistance; the overweight group demonstrated increased insulin resistance without significantly altered BMI z-scores. Long-term follow-up of BMI and insulin resistance changes in patients with CPP is required.

  20. Optofluidic refractive-index sensors employing bent waveguide structures for low-cost, rapid chemical and biomedical sensing.

    Science.gov (United States)

    Liu, I-Chen; Chen, Pin-Chuan; Chau, Lai-Kwan; Chang, Guo-En

    2018-01-08

    We propose and develop an intensity-detection-based refractive-index (RI) sensor for low-cost, rapid RI sensing. The sensor is composed of a polymer bent ridge waveguide (BRWG) structure on a low-cost glass substrate and is integrated with a microfluidic channel. Different-RI solutions flowing through the BRWG sensing region induce output optical power variations caused by optical bend losses, enabling simple and real-time RI detection. Additionally, the sensors are fabricated using rapid and cost-effective vacuum-less processes, attaining the low cost and high throughput required for mass production. A good RI solution of 5.31 10 -4 × RIU -1 is achieved from the RI experiments. This study demonstrates mass-producible and compact RI sensors for rapid and sensitive chemical analysis and biomedical sensing.

  1. Effects of Sorghum [Sorghum bicolor (L. Moench] Crude Extracts on Starch Digestibility, Estimated Glycemic Index (EGI, and Resistant Starch (RS Contents of Porridges

    Directory of Open Access Journals (Sweden)

    Dilek Lemlioglu-Austin

    2012-09-01

    Full Text Available Bran extracts (70% aqueous acetone of specialty sorghum varieties (tannin, black, and black with tannin were used to investigate the effects of sorghum phenolic compounds on starch digestibility, Estimated Glycemic Index (EGI, and Resistant Starch (RS of porridges made with normal corn starch, enzyme resistant high amylose corn starch, and ground whole sorghum flours. Porridges were cooked with bran extracts in a Rapid Visco-analyser (RVA. The cooking trials indicated that bran extracts of phenolic-rich sorghum varieties significantly reduced EGI, and increased RS contents of porridges. Thus, there could be potential health benefits associated with the incorporation of phenolic-rich sorghum bran extracts into foods to slow starch digestion and increase RS content.

  2. RiArsB and RiMT-11: Two novel genes induced by arsenate in arbuscular mycorrhiza.

    Science.gov (United States)

    Maldonado-Mendoza, Ignacio E; Harrison, Maria J

    Plants associated with arbuscular mycorrhizal fungi (AMF) increase their tolerance to arsenic-polluted soils. This study aims to investigate the genes involved in the AMF molecular response to arsenic pollution. Genes encoding proteins involved in arsenic metabolism were identified and their expression assessed by PCR or RT-qPCR. The As-inducible gene GiArsA (R. irregularis ABC ATPase component of the ArsAB arsenite efflux pump) and two new genes, an arsenate/arsenite permease component of ArsAB (RiArsB) and a methyltransferase type 11 (RiMT-11) were induced when arsenate was added to two-compartment in vitro monoxenic cultures of R. irregularis-transformed carrot roots. RiArsB and RiMT-11 expression in extraradical hyphae in response to arsenate displayed maximum induction 4-6 h after addition of 350 μM arsenate. Their expression was also detected in colonized root tissues grown in pots, or in the root-fungus compartment of two-compartment in vitro systems. We used a Medicago truncatula double mutant (mtpt4/mtpt8) to demonstrate that RiMT-11 and RiArsB transcripts accumulate in response to the addition of arsenate but not in response to phosphate. These results suggest that these genes respond to arsenate addition regardless of non-functional Pi symbiotic transport, and that RiMT-11 may be involved in arsenate detoxification by methylation in AMF-colonized tissues. Copyright © 2017 British Mycological Society. All rights reserved.

  3. A comparative study of the refractive index of silk protein thin films towards biomaterial based optical devices

    Science.gov (United States)

    Bucciarelli, A.; Mulloni, V.; Maniglio, D.; Pal, R. K.; Yadavalli, V. K.; Motta, A.; Quaranta, A.

    2018-04-01

    Over the last two decades, silk fibroin has been exploited as a versatile optical material in biological applications due to a combination of unique properties. Recently, protocols have been developed to produce a silk fibroin negative tone resist that is UV crosslinkable, thereby allowing micro and nanoscale patterning of the protein using traditional photolithographic tools. The same protocol has been applied to the silk protein sericin to develop a sericin resist. Despite the immense potential of these biomaterials to develop micro optical patterns on silicon and glass surfaces, as well as self-standing components, their refractive indexes are not well characterized. In this work, optimizing a method to obtain extremely smooth, thin films, the refractive index (RI) of fibroin and sericin proteins and resists were characterized using ellipsometry. The parameters of the Sellmeier and Cauchy dispersion laws have been determined to obtain the RI over a large wavelength range. A complete morphological study of the films has been conducted. In addition, the effect of solvent on the optical properties of silk fibroin and sericin thin films are reported, with differences in values explained by examining the change in the protein secondary structure.

  4. High throughput resistance profiling of Plasmodium falciparum infections based on custom dual indexing and Illumina next generation sequencing-technology

    DEFF Research Database (Denmark)

    Nag, Sidsel; Dalgaard, Marlene Danner; Kofoed, Poul-Erik

    2017-01-01

    Genetic polymorphisms in P. falciparum can be used to indicate the parasite's susceptibility to antimalarial drugs as well as its geographical origin. Both of these factors are key to monitoring development and spread of antimalarial drug resistance. In this study, we combine multiplex PCR, custo...

  5. DNA Nucleotide Sequence Restricted by the RI Endonuclease

    Science.gov (United States)

    Hedgpeth, Joe; Goodman, Howard M.; Boyer, Herbert W.

    1972-01-01

    The sequence of DNA base pairs adjacent to the phosphodiester bonds cleaved by the RI restriction endonuclease in unmodified DNA from coliphage λ has been determined. The 5′-terminal nucleotide labeled with 32P and oligonucleotides up to the heptamer were analyzed from a pancreatic DNase digest. The following sequence of nucleotides adjacent to the RI break made in λ DNA was deduced from these data and from the 3′-dinucleotide sequence and nearest-neighbor analysis obtained from repair synthesis with the DNA polymerase of Rous sarcoma virus [Formula: see text] The RI endonuclease cleavage of the phosphodiester bonds (indicated by arrows) generates 5′-phosphoryls and short cohesive termini of four nucleotides, pApApTpT. The most striking feature of the sequence is its symmetry. PMID:4343974

  6. RI beam factory and its expected pioneering work

    International Nuclear Information System (INIS)

    Yano, Yasushige

    1996-01-01

    The RARF (RIKEN Accelerator Research Facility) houses an intermediate-energy heavy-ion accelerator complex consisting of a K540-MeV ring cyclotron (RRC) and a couple of different types of the injectors: a variable-frequency heavy-ion linac and a K70-MeV AVF cyclotron. One of remarkable features of this facility is capability of supplying light-atomic-mass RI (radioactive isotope) beams with the world-highest level of intensities by the projectile-fragment separator, RIPS. In these several years nuclear physicists have opened up a quite new and fascinating heavy-ion science exploiting such RI beams. In order to further promote this new science, the RARF proposes 'RIKEN RI Beam Factory' as a next facility-expanding project. The factory takes the aim at providing RI beams covering over the whole atomic-mass range with the world-highest intensities in a wide energy range up to several hundreds MeV/nucleon. To realize the 'Factory' a K2500-MeV superconducting ring cyclotron will be built which boosts output energies of the RRC beams up to 400 MeV/nucleon for light ions and up to 100 MeV/nucleon for very heavy ions, preserving their beam intensities (typically 1 pμA). RI beams will be generated by the projectile fragmentation. A new type of experimental installation called 'MUSES' (Multi-USe Experimental Storage rings) will also be constructed. It consists of an accumulator-cooler ring, booster synchrotron ring and double storage rings. With MUSES, various types of unique colliding experiments will become possible: ion-ion merging or head-on collisions; collisions of either electrons or X-rays with ion (stable isotope or RI) beams; internal target experiments; and atomic and molecular physics with cooler electron beams. (author)

  7. Refractive index sensors based on the fused tapered special multi-mode fiber

    Science.gov (United States)

    Fu, Xing-hu; Xiu, Yan-li; Liu, Qin; Xie, Hai-yang; Yang, Chuan-qing; Zhang, Shun-yang; Fu, Guang-wei; Bi, Wei-hong

    2016-01-01

    In this paper, a novel refractive index (RI) sensor is proposed based on the fused tapered special multi-mode fiber (SMMF). Firstly, a section of SMMF is spliced between two single-mode fibers (SMFs). Then, the SMMF is processed by a fused tapering machine, and a tapered fiber structure is fabricated. Finally, a fused tapered SMMF sensor is obtained for measuring external RI. The RI sensing mechanism of tapered SMMF sensor is analyzed in detail. For different fused tapering lengths, the experimental results show that the RI sensitivity can be up to 444.517 81 nm/RIU in the RI range of 1.334 9—1.347 0. The RI sensitivity is increased with the increase of fused tapering length. Moreover, it has many advantages, including high sensitivity, compact structure, fast response and wide application range. So it can be used to measure the solution concentration in the fields of biochemistry, health care and food processing.

  8. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

    DEFF Research Database (Denmark)

    Manning, Alisa K; Hivert, Marie-France; Scott, Robert A

    2012-01-01

    pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci...... associated with fasting insulin at P triglyceride and lower high-density lipoprotein (HDL) cholesterol levels, suggesting a role for these loci...

  9. Optofluidic refractive index sensor based on partial reflection

    Science.gov (United States)

    Zhang, Lei; Zhang, Zhang; Wang, Yichuan; Ye, Meiying; Fang, Wei; Tong, Limin

    2017-06-01

    We demonstrate a novel optofluidic refractive index (RI) sensor with high sensitivity and wide dynamic range based on partial reflection. Benefited from the divergent incident light and the output fibers with different tilting angles, we have achieved highly sensitive RI sensing in a wide range from 1.33 to 1.37. To investigate the effectiveness of this sensor, we perform a measurement of RI with a resolution of ca. 5.0×10-5 refractive index unit (RIU) for ethylene glycol solutions. Also, we have measured a series of liquid solutions by using different output fibers, achieving a resolution of ca. 0.52 mg/mL for cane surge. The optofluidic RI sensor takes advantage of the high sensitivity, wide dynamic range, small footprint, and low sample consumption, as well as the efficient fluidic sample delivery, making it useful for applications in the food industry.

  10. The effects of cinnamon on glycemic indexes and insulin resistance in adult male diabetic rats with streptozotocin

    OpenAIRE

    SEbrahim Hosseini; STaereh Shojaei; SAli Hosseini

    2015-01-01

    Background: Diabetes is a common disease that for its treatment and control different methods are recommended such as the use of natural remedies and lifestyle modification. Since the use of herbal medicines have less side effects than many chemical drugs, hence, this study aimed to investigate the effect of cinnamon extract on blood glucose, insulin and insulin resistance in diabetic rats with streptozotocin. Materials and Methods: This experimental study was conducted on 40 adult male rats,...

  11. Triglyceride Glucose-Body Mass Index Is a Simple and Clinically Useful Surrogate Marker for Insulin Resistance in Nondiabetic Individuals

    OpenAIRE

    Er, Leay-Kiaw; Wu, Semon; Chou, Hsin-Hua; Hsu, Lung-An; Teng, Ming-Sheng; Sun, Yu-Chen; Ko, Yu-Lin

    2016-01-01

    Background Insulin resistance (IR) and the consequences of compensatory hyperinsulinemia are pathogenic factors for a set of metabolic abnormalities, which contribute to the development of diabetes mellitus and cardiovascular diseases. We compared traditional lipid levels and ratios and combined them with fasting plasma glucose (FPG) levels or adiposity status for determining their efficiency as independent risk factors for IR. Methods We enrolled 511 Taiwanese individuals for the analysis. T...

  12. Optimal cutoff for the evaluation of insulin resistance through triglyceride-glucose index: A cross-sectional study in a Venezuelan population.

    Science.gov (United States)

    Salazar, Juan; Bermúdez, Valmore; Calvo, María; Olivar, Luis Carlos; Luzardo, Eliana; Navarro, Carla; Mencia, Heysa; Martínez, María; Rivas-Ríos, José; Wilches-Durán, Sandra; Cerda, Marcos; Graterol, Modesto; Graterol, Rosemily; Garicano, Carlos; Hernández, Juan; Rojas, Joselyn

    2017-01-01

    Background: Insulin resistance (IR) evaluation is a fundamental goal in clinical and epidemiological research. However, the most widely used methods are difficult to apply to populations with low incomes. The triglyceride-glucose index (TGI) emerges as an alternative to use in daily clinical practice. Therefore the objective of this study was to determine an optimal cutoff point for the TGI in an adult population from Maracaibo, Venezuela. Methods: This is a sub-study of Maracaibo City Metabolic Syndrome Prevalence Study, a descriptive, cross-sectional study with random and multi-stage sampling. For this analysis, 2004 individuals of both genders ≥18 years old with basal insulin determination and triglycerides triglyceride (mg / dl) x Fasting glucose (mg / dl)] / 2. Results: The TGI in the general population was 4.6±0.3 (male: 4.66±0.34 vs. female: 4.56±0.33, p=8.93x10 -10 ). The optimal cutoff point was 4.49, with a sensitivity of 82.6% and specificity of 82.1% (AUC=0.889, 95% CI: 0.854-0.924). There were no significant differences in the predictive capacity of the index when evaluated according to gender and age groups. Those individuals with TGI≥4.5 had higher HOMA2-IR averages than those with TGI index to determine atypical metabolic phenotypes, type 2 diabetes mellitus and even cardiovascular risk in our population.

  13. Dietary phytochemical index and the risk of insulin resistance and β-cell dysfunction: a prospective approach in Tehran lipid and glucose study.

    Science.gov (United States)

    Bahadoran, Zahra; Mirmiran, Parvin; Tohidi, Maryam; Azizi, Fereidoun

    2015-01-01

    In this study, we aimed to investigate the association of dietary phytochemical index (DPI) with insulin resistance, β-cell dysfunction, and insulin sensitivity. This longitudinal study was conducted on 1141 participants of the Tehran Lipid and Glucose Study. Dietary data were collected using a validated semi-quantitative FFQ with 168 food items at baseline and DPI was calculated. Fasting serum insulin and glucose were measured at baseline and again after a 3-year of follow-up. After 3-years of follow-up, the risk of hyperinsulinemia significantly decreased by 65 (OR = 0.35, 95% CI = 0.21-0.60) and 86% (OR = 0.14, 0.07-0.29), in the third and fourth quartile categories of DPI, respectively. The occurrence of insulin resistance and insulin insensitivity in participants with higher DPI was significantly lower than the others (OR = 0.48, 95% CI = 0.25-0.93 and OR = 0.11, 95% CI = 0.05-0.24, respectively). Higher consumption of phytochemical-rich foods may have protective effects against development of insulin resistance.

  14. Beam optics simulation of rare-RI ring at RI beam factory in RIKEN

    International Nuclear Information System (INIS)

    Arai, I.; Ozawa, A.; Yasuda, Y.

    2009-01-01

    The cyclotron-like storage ring dedicated to Rare-RI Ring project consists of 6 magnetic sectors and 6 straight sections, having a circumference of 56.13 m. The magnetic sector works for both bending and focusing. The total circulation is assumed to be 1,000 turns. Over the momentum range from -1% to +1% in ∆p/p, the required isochronicity is 10 -6 while the beam emittance is several tens of π mm-mrad. To examine the design of cyclotron-like storage ring and fix its parameters, we have developed a high precision beam optics simulation. To achieve the precision as high as possible within a feasible computational time, we have adopted a geometrical tracking assuming a circular orbit for a small spatial segment. For that purpose, it is enough that the magnetic sector is divided into 150 sub-sectors in calculation. In each sub-sector, the magnetic field is given as a function of radial position but uniform around the vicinity of beam trajectory. The beam trajectory is evaluated in 4th order Runge-Kutta algorithm. Finally, we have achieved a precision of 10 -9 in ∆T/T and a computational time of 1.8 sec on a typical PC server for ray tracing of single particle undergoing a circulation of 1,000 turns. (author)

  15. Eduard Vääri : [Wiedemanni keeleauhinna laureaat 2001

    Index Scriptorium Estoniae

    2005-01-01

    Sisu: Kogu elu eesti keele kaitsel : [F. J. Wiedemanni keeleauhinna vastuvõtmisel peetud kõne alusel] ; Laks, Meinhard. Liivi rannarahva lipp : [luuletus] = Livõ rńdarouv plaga / liivi keelde tõlkinud Eduard Vääri

  16. Rahvus, "glokaalsus" ja eesti kirjandusdiskursus aastatuhandevahetusel / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2001-01-01

    Bibliogr. joonealustes märkustes. Artikli aluseks on rahvusvahelisel konverentsil "Cultural Identity and Its Glocal Manifestations" (Joensuu, 14.-16. IX 2000) peetud ingliskeelne ettekanne. Artikkel on ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 31-45

  17. Imaging of the bronchial blood flow using RI-angiography

    International Nuclear Information System (INIS)

    Fujii, Tadashige; Hirayama, Jiro; Kanai, Hisakata; Kobayashi, Toshio; Handa, Kenjiro

    1979-01-01

    RI-angiography with sup(99m)TcO 4 - was carried out using a scintillation camera with a digital minicomputer for the purpose of imaging of bronchial blood flow in various lung diseases, and as application of dual radioisotope techniques, other imagings such as tumor imaging with 197 HgCl 2 or 67 Ga-citrate and/or perfusion imaging with sup(99m)Tc-MAA, were performed simultaneously in patients remaining the same position, too. The image as a iso-count map extracted out of the image of 197 HgCl 2 , 67 Ga-citrate or sup(99m)Tc-MAA, was superimposed to the brightness image of RI-angiogram (aortic phase). By these procedures, the image of bronchial blood flow were obtained in some patients with lung cancer, pulmonary tuberculosis, lung abscess, and chronic bronchitis. The dual radioisotope techniques using RI-angiography and the other imaging were useful to make isotope diagnosis of lung diseases more reliable, and the image superimposition methods using RI-angiogram and the image of tumor of perfusion, were useful to improve anatomic orientation of the former. (author)

  18. Hispaania kirjanduse elav keha / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1996-01-01

    Keha ja kehatus hispaania kirjanduses (Cervantese Dulcinea, Sancho Panza, don Quijote) ja maailmakirjanduses esinevate tegelaskujude näiteil : Ka Tõnu Õnnepalu Joonatanist romaanis 'Hind'. Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 469-473

  19. Võrguäri Eestis kiratseb / Indrek Kald

    Index Scriptorium Estoniae

    Kald, Indrek, 1974-

    2004-01-01

    Autor otsib põhjusi, miks tänavuse Interneti-kaupluste edetabeli koostamiseks saatis oma äritulemused vaid viis võrgukauplust. Zebra Infosüsteemide tegevjuhi Peeter Tamme arvamus e-äri kiratsemise põhjuste kohta

  20. Äri domeeninimedega kogub Ameerikas hoogu / Margus Mihkels

    Index Scriptorium Estoniae

    Mihkels, Margus

    2006-01-01

    2005. aastal müüdi Ameerikas 5851 domeeninime ja nimeäri käive ulatus 29 miljoni USA dollarini. 2006. aasta esimese kolme kuu jooksul on ajakirja Domain Name Journal andmetel müüdud 1949 veebiaadressi 14,2 miljoni dollari eest

  1. Eksjuhtide hoogne kinnisvaraäri / Koit Brinkmann

    Index Scriptorium Estoniae

    Brinkmann, Koit

    2007-01-01

    Endised Skanska EMV juhid Jaanus Otsa ja Olaf Herman ajasid põhitöökoha kõrvalt tulusat eraäri. Lisad: Skanska partnerlus Mati Tusoviga; Palju firmasid, kuid samad nimed; Väljavõte Skanska eetikakoodeksist. Kommenteerib Mika Toivola

  2. Arved Viirlaid teises kaanonis / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2002-01-01

    Arved Viirlaid 80. Ka tema juubeliks ilmunud ingliskeelsest luulekogust "Selected poems" (tlk. Taimi Ene Moks ja R. W. Stedingh). Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 417-420, pealk.: Teises Kaanonis: Viirlaiu luule inglise keeles

  3. Tartu kui märk / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1996-01-01

    Ilmus algkujul hispaania keeles Sevillas Andaluusia Semiootikaassotsiatsiooni ajakirja Discurso Tartu semiootikakoolkonnale pühendatud erinumbris (nr. 8, 1993). Ilmunud ka kogumikus: Talvet, Jüri. Ameerika märkmeid, ehk, Kaemusi Eestist. Tartu : Ilmamaa, 2000, lk. 62-71, pealk.: Tartu vaim

  4. Sonya Smith ja telenovela-äri / Tiina Lepiste

    Index Scriptorium Estoniae

    Lepiste, Tiina

    2006-01-01

    Telenovelade ärist ja fenomenist. Ka Venetsueela päritolu näitlejannast Sonya Smithist seriaalis "Armastuse jõud". Sama: Teleleht, 17. Jul. 2006, nr. 28, lk. 6-7 : ill pealkirjaga "Seebiäri vohab ja õitseb"

  5. Mida me Tallinnas teinud oleme / Jüri Ratas

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2006-01-01

    Tallinna linnapea Jüri Ratas annab ülevaate linnavalitsuse tegevusest esimese saja päeva jooksul. Linnavalitsuse tegevust hindavad Tallinna volikogu Isamaaliidu fraktsiooni esimees Toomas Tõniste, volikogu Reformierakonna esimees Keit Pentus ja volikogu sotsiaaldemokraatide fraktsiooni aseesimees Hannes Rumm

  6. Structure of RiVax: a recombinant ricin vaccine

    International Nuclear Information System (INIS)

    Legler, Patricia M.; Brey, Robert N.; Smallshaw, Joan E.; Vitetta, Ellen S.; Millard, Charles B.

    2011-01-01

    The X-ray crystal structure (at 2.1 Å resolution) of an immunogen under development as part of a ricin vaccine for humans is presented and structure-based analysis of the results was conducted with respect to related proteins and the known determinants for inducing or suppressing the protective immune response. RiVax is a recombinant protein that is currently under clinical development as part of a human vaccine to protect against ricin poisoning. RiVax includes ricin A-chain (RTA) residues 1–267 with two intentional amino-acid substitutions, V76M and Y80A, aimed at reducing toxicity. Here, the crystal structure of RiVax was solved to 2.1 Å resolution and it was shown that it is superposable with that of the ricin toxin A-chain from Ricinus communis with a root-mean-square deviation of 0.6 Å over 258 C α atoms. The RiVax structure is also compared with the recently determined structure of another potential ricin-vaccine immunogen, RTA 1–33/44–198 R48C/T77C. Finally, the locations and solvent-exposure of two toxin-neutralizing B-cell epitopes were examined and it was found that these epitopes are within or near regions predicted to be involved in catalysis. The results demonstrate the composition of the RiVax clinical material and will guide ongoing protein-engineering strategies to develop improved immunogens

  7. Diagnostic Validity of RI Angiocardiography in Cardiac Diseases

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwan Yop; Koh, Chang Soon; Lee, Mun Ho [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1972-09-15

    The employment of gamma-ray scintillation camera with the use of short-lived radioisotopic pharmaceuticals, such as {sup 99m}Tc sodium pertechnetate, have enabled us to perform RI (radioisotopic) angiocardiography. Although conventional cardiac catheterization or angiocardiography using contrast media have been an important diagnostic tool, they may carry some risks or serious complications. The author investigated on RI angiocardiography in twelve normal and twenty five patients with cardiovascular diseases in an effort to evaluate its diagnostic value. The results obtained with this study are as follows; l. In normal subjects, the scintillation camera transit time of arm-to-right heart was found to be 2.1+-0.67 seconds, right heart-to-lung 1.5+-0.40 seconds and lung-to-left heart 3.5+-0.86 seconds. 2. Transformation or displacement of the heart and the great vessel are easily discriminated by RI angiocardiography. Both in the cases with tricuspid atresia and tetralogy of Fallot, ventricular septal defects are well recognized by sequential RI angiocardiography. 3. It is also helpful in determining the site and extent of obstruction, and estimating the postoperative course both in the cases with superior vena cava syndrome and pulmonary stenosis. 4. Pericarditis with effusion is readily diagnosed by RI angiocardiogram showing characteristic 'dead space' between intracardiac and intrapulmonary radioactivity. 5. It was found that the diagnostic accuracy of this study was 78.4%. It is concluded that above results obtained are useful and accurate enough for the diagnostic screening method for clinical practice.

  8. Diagnostic Validity of RI Angiocardiography in Cardiac Diseases

    International Nuclear Information System (INIS)

    Kim, Kwan Yop; Koh, Chang Soon; Lee, Mun Ho

    1972-01-01

    The employment of gamma-ray scintillation camera with the use of short-lived radioisotopic pharmaceuticals, such as 99m Tc sodium pertechnetate, have enabled us to perform RI (radioisotopic) angiocardiography. Although conventional cardiac catheterization or angiocardiography using contrast media have been an important diagnostic tool, they may carry some risks or serious complications. The author investigated on RI angiocardiography in twelve normal and twenty five patients with cardiovascular diseases in an effort to evaluate its diagnostic value. The results obtained with this study are as follows; l. In normal subjects, the scintillation camera transit time of arm-to-right heart was found to be 2.1±0.67 seconds, right heart-to-lung 1.5±0.40 seconds and lung-to-left heart 3.5±0.86 seconds. 2. Transformation or displacement of the heart and the great vessel are easily discriminated by RI angiocardiography. Both in the cases with tricuspid atresia and tetralogy of Fallot, ventricular septal defects are well recognized by sequential RI angiocardiography. 3. It is also helpful in determining the site and extent of obstruction, and estimating the postoperative course both in the cases with superior vena cava syndrome and pulmonary stenosis. 4. Pericarditis with effusion is readily diagnosed by RI angiocardiogram showing characteristic 'dead space' between intracardiac and intrapulmonary radioactivity. 5. It was found that the diagnostic accuracy of this study was 78.4%. It is concluded that above results obtained are useful and accurate enough for the diagnostic screening method for clinical practice.

  9. Diagnostic Validity of RI Angiocardiography in Cardiac Diseases

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwan Yop; Koh, Chang Soon; Lee, Mun Ho [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1972-09-15

    The employment of gamma-ray scintillation camera with the use of short-lived radioisotopic pharmaceuticals, such as {sup 99m}Tc sodium pertechnetate, have enabled us to perform RI (radioisotopic) angiocardiography. Although conventional cardiac catheterization or angiocardiography using contrast media have been an important diagnostic tool, they may carry some risks or serious complications. The author investigated on RI angiocardiography in twelve normal and twenty five patients with cardiovascular diseases in an effort to evaluate its diagnostic value. The results obtained with this study are as follows; l. In normal subjects, the scintillation camera transit time of arm-to-right heart was found to be 2.1+-0.67 seconds, right heart-to-lung 1.5+-0.40 seconds and lung-to-left heart 3.5+-0.86 seconds. 2. Transformation or displacement of the heart and the great vessel are easily discriminated by RI angiocardiography. Both in the cases with tricuspid atresia and tetralogy of Fallot, ventricular septal defects are well recognized by sequential RI angiocardiography. 3. It is also helpful in determining the site and extent of obstruction, and estimating the postoperative course both in the cases with superior vena cava syndrome and pulmonary stenosis. 4. Pericarditis with effusion is readily diagnosed by RI angiocardiogram showing characteristic 'dead space' between intracardiac and intrapulmonary radioactivity. 5. It was found that the diagnostic accuracy of this study was 78.4%. It is concluded that above results obtained are useful and accurate enough for the diagnostic screening method for clinical practice.

  10. Effective management of regulator RI/FS comments

    International Nuclear Information System (INIS)

    Wolinsky, S.M.; Lojek, D.; George, R.D.; Houser, S.M.; Strimbu, M.J.

    1995-01-01

    This paper describes a successful strategy that facilitates regulatory approval of CERCLA documents required by compliance agreement and CERCLA, based on the experience of Operable Unit 1, Waste Storage Area, of the Fernald Environmental Management Project (FEMP). This strategy, which has become the site standard at the FEMP, was instrumental in obtaining regulator approval of the OU1 RI and FS, and early approval of the Record of Decision during a very tight compliance agreement-driven schedule. This strategy can be applied at any DOE Superfund site, especially where there is need to recover lost schedule, an incentive to meet milestones early, a need to improve the relationship between the DOE and the regulators, or where the regulatory agencies have historically provided a large volume of comments on CERCLA documents. The strategy focuses on early identification and resolution of issues relating to draft RI/FS documents, as raised in regulatory agency review comments. This pro-active strategy has the potential for schedule and cost savings, as well as for improved communication between DOE and the regulators. The strategy includes preparation of a separate comment response document, integration of comment responses with RI/FS documents, development of a database of agency comments and their resolution, and sharing lessons learned with preparers of subsequent RI/FS documents. The paper provides background on the FEMP and describes the FEMP comment response strategy; DOE and regulator interface; the Sitewide Comment Database; networked electronic file management; the process for classifying, analyzing, and responding to comments; integration with base RI/FS documents; and a conclusion

  11. Effective management of regulator RI/FS comments

    Energy Technology Data Exchange (ETDEWEB)

    Wolinsky, S.M.; Lojek, D.; George, R.D.; Houser, S.M.; Strimbu, M.J.

    1995-12-31

    This paper describes a successful strategy that facilitates regulatory approval of CERCLA documents required by compliance agreement and CERCLA, based on the experience of Operable Unit 1, Waste Storage Area, of the Fernald Environmental Management Project (FEMP). This strategy, which has become the site standard at the FEMP, was instrumental in obtaining regulator approval of the OU1 RI and FS, and early approval of the Record of Decision during a very tight compliance agreement-driven schedule. This strategy can be applied at any DOE Superfund site, especially where there is need to recover lost schedule, an incentive to meet milestones early, a need to improve the relationship between the DOE and the regulators, or where the regulatory agencies have historically provided a large volume of comments on CERCLA documents. The strategy focuses on early identification and resolution of issues relating to draft RI/FS documents, as raised in regulatory agency review comments. This pro-active strategy has the potential for schedule and cost savings, as well as for improved communication between DOE and the regulators. The strategy includes preparation of a separate comment response document, integration of comment responses with RI/FS documents, development of a database of agency comments and their resolution, and sharing lessons learned with preparers of subsequent RI/FS documents. The paper provides background on the FEMP and describes the FEMP comment response strategy; DOE and regulator interface; the Sitewide Comment Database; networked electronic file management; the process for classifying, analyzing, and responding to comments; integration with base RI/FS documents; and a conclusion.

  12. Euroopa äriühingu mudel ja selle rakendamine finantssektori äriühingute poolt / Ingrid Ulst

    Index Scriptorium Estoniae

    Ulst, Ingrid, 1977-

    2005-01-01

    SE (Euroopa äriühingu) mudeli olemusest ja SE regulatsiooni olulisematest aspektidest, põgusalt Nordea Bank AB praegusest grupistruktuurist ja võimalikust restruktureerimisest. Lisatud tabel: Nordea Bank AB olulisemad grupiettevõtted ja järelevalve (01/01/2004)

  13. Tallinna linnapea Jüri Ratas : Keskerakond ei ole maffia! / Jüri Ratas ; interv. Urmo Soonvald

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2005-01-01

    Tallinna linnapea Jüri Ratas vastab küsimustele, mis puudutavad Rein Ratase Tallinna Vee nõukogu liikmeks määramist, K-kohukse reklaami seost Keskerakonna valimiskampaaniaga, linnapeaks saamist, koostööd teiste poliitikutega, Edgar Savisaare osa Tallinna linna juhtimises

  14. Äriühingute vastastikune tunnustamine ja asukohavahetus Euroopa Liidus / Andres Vutt

    Index Scriptorium Estoniae

    Vutt, Andres, 1969-

    2007-01-01

    Äriühingute vastastikuse tunnustamise põhimõtetest ja võimalustest, kuidas saab Euroopa Liidus muuta äriühingu asukohta ühest riigist teise ning mida tuleb Eestil seoses sellega arvestada. Äriühingute asukohavahetusest Euroopa Kohtu lahendites. Artikkel on valminud ETF-i grandi 6747 abil

  15. Nooruslik kaupmeheemand kavatseb äri laiendada / Hille Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Hille, 1941-2014

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 23. märts lk. 8. Tallinnas Vana-Kalamaja tänaval paikneva Alma Äri omanik Alma Sooäär avas oma esimese poe enam kui 15 aastat tagasi Nõmmel, praegu plaanib poeomanik majapidamistarvete äri laiendamist. Kaart: Alma Äri

  16. INDEXING AND INDEX FUNDS

    Directory of Open Access Journals (Sweden)

    HAKAN SARITAŞ

    2013-06-01

    Full Text Available Proponents of the efficient market hypothesis believe that active portfolio management is largely wasted effort and unlikely to justify the expenses incurred. Therefore, they advocate a passive investment strategy that makes no attempt to outsmart the market. One common strategy for passive management is indexing where a fund is designed to replicate the performance of a broad-based index of stocks and bonds. Traditionally, indexing was used by institutional investors, but today, the use of index funds proliferated among individual investors. Over the years, both international and domestic index funds have disproportionately outperformed the market more than the actively managed funds have.

  17. Elevated cranial ultrasound resistive indices are associated with improved neurodevelopmental outcomes one year after pediatric cardiac surgery: A single center pilot study.

    Science.gov (United States)

    Jenks, Christopher L; Hernandez, Ana; Stavinoha, Peter L; Morris, Michael C; Tian, Fenghua; Liu, Hanli; Garg, Parvesh; Forbess, Joseph M; Koch, Joshua

    To determine if a non-invasive, repeatable test can be used to predict neurodevelopmental outcomes in patients with congenital heart disease. This was a prospective study of pediatric patients less than two months of age undergoing congenital heart surgery at the Children's Health Children's Medical Center at Dallas. Multichannel near-infrared spectroscopy (NIRS) was utilized during the surgery, and ultrasound (US) resistive indices (RI) of the major cranial vessels were obtained prior to surgery, immediately post-operatively, and prior to discharge. Pearson's correlation, Fischer exact t test, and Fischer r to z transformation were used where appropriate. A total of 16 patients were enrolled. All had US data. Of the sixteen patients, two died prior to the neurodevelopmental testing, six did not return for the neurodevelopmental testing, and eight patients completed the neurodevelopmental testing. There were no significant correlations between the prior to surgery and prior to discharge US RI and neurodevelopmental outcomes. The immediate post-operative US RI demonstrated a strong positive correlation with standardized neurodevelopmental outcome measures. We were able to demonstrate qualitative differences using multichannel NIRS during surgery, but experienced significant technical difficulties implementing consistent monitoring. A higher resistive index in the major cerebral blood vessels following cardiac surgery in the neonatal period is associated with improved neurological outcomes one year after surgery. Obtaining an ultrasound with resistive indices of the major cerebral vessels prior to and after surgery may yield information that is predictive of neurodevelopmental outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Pilates versus resistance exercise on the serum levels of hs-CRP, in the abdominal circumference and body mass index (BMI in elderly individuals

    Directory of Open Access Journals (Sweden)

    Maria Adesilda Silva Pestana

    2016-06-01

    Full Text Available Recent studies have shown that the elderly exhibit a subclinical state of inflammation associated with increased adipose tissue and several comorbidities. To compare the effects of mat Pilates based exercises and resistance exercise on the serum levels of reactive C protein of high sensitivity (hs-CRP, in the abdominal circumference (AC and the body mass index (BMI in the elderly. It is a randomised clinical trial with a sample of 78 elderly individuals (median age 69 years. The active independent variable investigated was nature of treatment intervention (Pilates mat based exercises vs resistance exercise, and the dependent variables were hs-CRP level, AC and BMI. The statistical analysis used Wilcoxon signed rank and Mann-Whitney tests. The correlation between the continuous variables was assessed using Spearman’s coefficient of correlation. The data were analysed using SPSS software version 17.0, and probability values lower than 5% (p< 0.05 were considered statistically significant. Mat Pilates based exercises exhibited reductions in serum hs-CPR level (Wilcoxon signed rank test; z = -2.466, p = 0.01, BMI (Wilcoxon signed rank test; z = -3.295, p = 0.001 and AC (Wilcoxon signed rank test; z = -3.398, p = 0.01. Mat Pilates based exercises promoted a significant reduction of the serum hs-CRP levels and anthropometric measurements in elderly individuals.

  19. The effect of aerobic training on CXL5, tumor necrosis factor α and insulin resistance index (HOMA-IR) in sedentary obese women.

    Science.gov (United States)

    Zehsaz, Farzad; Farhangi, Negin; Mirheidari, Lamia

    2014-01-01

    The purpose of the present study was to investigate the effects of a 12-week training program on serum CXC ligand 5, tumor necrosis factor α (TNF-α) and insulin resistance index in obese sedentary women. To this end, twenty-four obese sedentary women were evaluated before and after a 12-week exercise program including a brief warm-up, followed by ~45 min per session of aerobic exercise at an intensity of 60-75% of age-predicted maximum heart rate (~300 kcal/day), followed by a brief cool down, five times per week. After the exercise program, body weight, waist circumference, waist to hip ratio, percentage body fat mass, fasting glucose and insulin of participants were decreased. Furthermore, serum CXCL5 levels were significantly decreased from 2693.2 ±375.8 to 2290.2 ±345.9 pg/ml (p HOMA-IR (p < 0.001) and TNF-α (p < 0.001). Exercise training induced weight loss resulted in a significant reduction in serum CXCL5 concentrations and caused an improvement in insulin resistance in obese sedentary women.

  20. The Effect of Two Acute Eccentric and Concentric Exercises on Serum Irisin Level and Insulin Resistance Index in Inactive Obese Women

    Directory of Open Access Journals (Sweden)

    Faranak Balaghi Inaloo

    2016-12-01

    Full Text Available Abstract Background: Recently a myokine named irisin has been discovered that effects on obesity, metabolism and glucose homeostasis through browning white adipose tissue and thermogenesis. However, the effects of type and intensity of exercises on it have remained unclear. The purpose of this study was to evaluate the effects of two acute eccentric and concentric exercises on serum irisin level and insulin resistance in obese sedentary women. Materials and Methods: The study was quasi-experimental. 15 female students with a body mass index above 30 kg/m2 and mean age 24.86±2.87 years participated in the study. After measuring the maximal uptake oxygen of participants, they did two acute eccentric and concentric exercises using treadmill in a cross-over design within 10 days. After at least 8 hours- fasting, blood samples were collected before and immediately after each activity, to measure the levels of irisin, glucose and insulin. Data were analyzed using paired t-test and repeated measures ANOVA. In addition, Pearson correlation was used to examine the relationship between variables. Results: the irisin levels increased significantly after both types of exercises (p<0.05, that this increase in concentric activity was more than eccentric activity. Insulin resistance increased immediately after both exercises as well, that this increase in concentric exercise was statistically significant (p<0.05. Conclusion: However, both eccentric and concentric exercises had no effect on improving insulin resistance in obese women, but they can be considered as a good stimulus for the secretion of Irisin.

  1. Analytical Characterization of the Hydrolysis of Barley Malt Macromolecules During Enzymatic Degradation Over Time Using AF4/MALS/RI.

    Science.gov (United States)

    Rübsam, Heinrich; Becker, Thomas; Gastl, Martina

    2017-06-01

    The changes on the molecular weight distribution (MWD) and particle size distribution (PSD) during hydrolysis of barley malt in isothermal mashing procedures were determined using asymmetrical flow field flow fractionation coupled to multiangle laser light scattering and refractive index (AF4/MALS/RI). Mash/trials were focused on amylolytic starch degradation. Therefore, temperatures (65, 70, and 75 °C) were selected according to α- and β-amylases range of activity. Samples were produced by triplicate, tracking amylolytic processes over time periods from 10 to 90 min in each mash/trial. AF4/MALS/RI analysis demonstrated significant differences on the values of the MWD and PSD according to the temperature/time profile used. At mashing times over 30 min at a temperature of 65 °C, when α- and β-amylase are both active, the decrease over time of the MWD and PSD was significantly higher (P < 0.005) than at 70 °C when mainly α-amylase is active. At 75 °C, also the activity of α-amylase decreased and the MWD and PSD were significantly lower (P < 0.005) than at 70 or 65 °C at any time of the procedure. The MWD and PSD of beer components influence beer palate fullness, thus AF4/ MALS/RI would be a powerful tool for breweries to adapt their technological processes to obtain beers with particular sensorial attributes. © 2017 Institute of Food Technologists®.

  2. Proceeding of the workshop on gamma-ray spectroscopy utilizing heavy-ion, photon and RI beams

    Energy Technology Data Exchange (ETDEWEB)

    Oshima, Masumi; Sugita, Michiaki; Hayakawa, Takehito [eds.

    1998-03-01

    Three time since 1992, we have held the symposia entitled `Joint Spectroscopy Experiments Utilizing JAERI Tandem-Booster Accelerator` at the Tokai Research Establishment. In the symposia, we have mainly discussed the plans of experiments to be done in this joint program. The joint program started in 1994. Several experiments have been made since and some new results have already come up. This symposium `Gamma-ray Spectroscopy utilizing heavy-ion, Photon and RI beams` was held at Tokai Research Establishment of JAERI. Because this symposium is the first occasion after the program started, the first purpose of the symposium is to present and discuss the experimental results so far obtained using the JAERI Tandem-Booster. The second purpose of the symposium is to discuss new possibilities of gamma-ray spectroscopy using new resources such as RI-beam and Photon-beam. The participants from RIKEN, Tohoku University and JAERI Neutron Science Research Center presented the future plans of experiments with RI-beam at each facility. Compared with these nuclear beams, photon beam provides a completely new tool for the {gamma}-ray spectroscopy, which is achieved by inverse Compton scattering between high-energy electron and laser beams. The 23 of the presented papers are indexed individually. (J.P.N.)

  3. Índice de resistividade renal como preditor da revascularização renal para hipertensão renovascular Índice de resistividad renal como predictor de la revascularización renal para hipertensión renovascular Renal resistance index predicting outcome of renal revascularization for renovascular hypertension

    Directory of Open Access Journals (Sweden)

    Simone N. Santos

    2010-04-01

    exitosa, ni todos los pacientes (pt expresan mejora clínica y algunos pueden empeorar. OBJETIVO: El presente estudio está destinado a evaluar el valor del índice de resistividad renal (IR como predictor de los efectos de la revascularización renal. MÉTODOS: Entre enero de 1998 y febrero de 2001, 2933 pacientes se sometieron al ultrasonido Doppler dúplex renal. Un total de 106 de estos pacientes expresaron EAR significativa y fueron sometidos a angiografía y revascularización renal. Se midió la presión arterial (PA antes y después de la intervención, en intervalos de hasta 2 años y las medicaciones prescriptas fueron registradas. Antes de la revascularización, el IR se midió en 3 locales del riñón, con la obtención de un promedio de estas mediciones. RESULTADOS: De los 106 pacientes, 81 tuvieron IR 80. La EAR se corrigió solamente por angioplastia (PTA en 25 pts, PTA + stent en 56 pts y quirúrgicamente en 25 pts. De los pacientes que se beneficiaron de la revascularización renal; 57 de los 81 pacientes con IR 80. Usando un modelo de regresión logística múltiple, el IR estuvo significativamente asociado a la evolución de la PA (p = 0,001, ajustado de acuerdo con los efectos de la edad, sexo, PAS, PAD, duración de la hipertensión, el tipo de revascularização, número de fármacos en uso, nivel de creatinina, presencia de DM, hipercolesterolemia, volumen sistólico, enfermedad arterial periférica y coronaria y tamaño renal (OR 99,6-95%CI para OR 6,1-1.621,2. CONCLUSIÓN: La resistividad intrarrenal arterial, medida por ultrasonido Doppler dúplex, desempeña un rol importante en la predicción de los efectos post revascularização renal para EAR.BACKGROUND: Renal artery stenosis (RAS is a potentially correctable cause of hypertension and ischemic nephropathy. Despite successful renal revascularization, not all patients (pt overcome it and some get worse. OBJECTIVE: This study was designed to assess the value of renal resistance index (RI in

  4. Current situation of RI's and radiation utilization in Japan

    International Nuclear Information System (INIS)

    1976-01-01

    Usage of RIs and radiation is now extensive, for the improvement of industrial production techniques and also in medicine and agriculture. The current situation in Japan is described as follows: enterprises using RIs, circulation of RIs, the equipments provided with RIs in private enterprises, commercial RI, and radiation utilization, expenditures and sales related to RIs and radiation in mining and industries, and personnel. The number of places using RIs and radiation totaled about 3,200 (in 1975). The expenditures for RIs and radiation in private enterprises are about 17,500 million yen while sales are 20,800 million yen (both in fiscal 1974). The total number of personnel engaged in RI and radiation works is about 62,000. (Mori, K.)

  5. Framework for applying RI-ISI methodology for Indian PHWRs

    International Nuclear Information System (INIS)

    Vinod, Gopika; Saraf, R.K.; Ghosh, A.K.; Kushwaha, H.S.

    2006-01-01

    Risk Informed In-Service Inspection (RI-ISI) aims at categorizing the components for In-Service inspection based on their contribution to Risk. For defining the contribution of risk from components, their failure probabilities and its subsequent effect on Core Damage Frequency (CDF) needs to be evaluated using Probabilistic Safety Assessment methodology. During the last several years, both the U.S. Nuclear Regulatory Commission (NRC) and the nuclear industry have recognized that Probabilistic Safety Assessment (PSA) has evolved to be more useful in supplementing traditional engineering approaches in reactor regulation. The paper highlights the various stages involved in applying RI-ISI and then compares the findings with existing ISI practices. (author)

  6. Uudised : Fääri ooper Tallinnas. Sigur Ros Tallinnas

    Index Scriptorium Estoniae

    2008-01-01

    10.-12. septembrini mängitakse Tallinnas Kultuurikatlas fääri helilooja Sunleif Rasmusseni ooperit "Hullu mehe aias", lavastajaks Robert Annus. 23. augustil annab Rock Cafés kontserdi Islandi eksperimentaalrocki ansambel Sigur Ros, kes esitleb oma viiendat albumit "Med sud i eyrum vid spilum endalaust" (mida võiks tõlkida "Mängime lõppematult, sumin kõrvus"

  7. USA kahepaiksest mängust / Jüri Lina

    Index Scriptorium Estoniae

    Lina, Jüri, 1949-

    2000-01-01

    Sama artikkel on ilmunud ka Eesti 2000 : sõltumatu almanahh ühiskonna ja vaimuelu küsimustes nr. 4 ja nr. 6. Autori väitel on USA muu hulgas huvitatud maakera rahvastiku drastilisest vähendamisest, seepärast ongi pärast Teist maailmasõda kunstlikult lõkkele puhutud sadu sõjalisi konflikte. Lisatud Jüri Lina lühielulugu lk. 23

  8. Moskvast tuli Eestisse Hõbe-Jüri / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2004-01-01

    Moskvas lõppes XXVI rahvusvaheline filmifestival. Festivali programmi kuulus ka Renee Reinumäe, Jaak Kilmi noortefilm, mis sai žürii eripreemia, Hõbedase Püha Jüri. Peapreemia sai venelase Dmitri Meshijevi "Omad". Noorte lootustandvate režissööride programmis oli huvitav prantslase Christophe Honoré "Minu ema". Lisatud auhinnatute nimekiri ning nimekiri "Eesti filmide tähtsamaid autasusid"

  9. Preliminary Beam Irradiation Test for RI Production Targets at KOMAC

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Sang Pil; Kwon, Hyeok Jung; Kim, Han Sung; Cho, Yong Sub; Seol, Kyung Tae; Song, Young Gi; Kim, Dae Il; Jung, Myung Hwan; Kim, Kye Ryung; Min, Yi Sub [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    The new beamline and target irradiation facility has been constructed for the production of therapeutic radio-isotope. Sr-82 and Cu-67 were selected as the target isotope in this facility, they are promising isotope for the PET imaging and cancer therapy. For the facility commissioning, the irradiation test for the prototype-target was conducted to confirm the feasibility of radio-isotope production, the proto-type targets are made of RbCl pellet and the natural Zn metal for Sr-82 and Cu-67 production respectively, In this paper, an introduction to the RI production targetry system and the results of the preliminary beam irradiation test are discussed. the low-flux beam irradiation tests for proto-type RI target have been conducted. As a result of the beam irradiation tests, we could obtain the evidence of Sr-82 and Cu-67 production, have confirmed the feasibility of Sr-82 and Cu-67 production at KOMAC RI production facility.

  10. Preliminary Beam Irradiation Test for RI Production Targets at KOMAC

    International Nuclear Information System (INIS)

    Yoon, Sang Pil; Kwon, Hyeok Jung; Kim, Han Sung; Cho, Yong Sub; Seol, Kyung Tae; Song, Young Gi; Kim, Dae Il; Jung, Myung Hwan; Kim, Kye Ryung; Min, Yi Sub

    2016-01-01

    The new beamline and target irradiation facility has been constructed for the production of therapeutic radio-isotope. Sr-82 and Cu-67 were selected as the target isotope in this facility, they are promising isotope for the PET imaging and cancer therapy. For the facility commissioning, the irradiation test for the prototype-target was conducted to confirm the feasibility of radio-isotope production, the proto-type targets are made of RbCl pellet and the natural Zn metal for Sr-82 and Cu-67 production respectively, In this paper, an introduction to the RI production targetry system and the results of the preliminary beam irradiation test are discussed. the low-flux beam irradiation tests for proto-type RI target have been conducted. As a result of the beam irradiation tests, we could obtain the evidence of Sr-82 and Cu-67 production, have confirmed the feasibility of Sr-82 and Cu-67 production at KOMAC RI production facility

  11. Space and Salvation in Colette's Chéri and La Fin de Chéri

    Directory of Open Access Journals (Sweden)

    Ann Leone Philbrick

    1984-01-01

    Full Text Available Colette's critics often seem to dismiss all but her autobiographical creatures as whimsical and inarticulate. Her characters are frequently less eloquent than the spaces they create and inhabit; this observation offers an approach to Chéri and La Fin de Chéri that invites us to read them as two of Colette's most ambitious and authentic works. Here are stories of compromises with the containers of one's life and identity: streets, salons, boudoirs, and, ultimately, the body. Indeed, the self and its containers function symbiotically. Chéri makes no effort to direct this relationship, and kills himself when the world finally seems inscrutable and formless; his older mistress, Léa, responds joyfully—or with melancholic respect—to the surfaces and limits of her world. We are left with a harsher insight into Colette's vision than we are accustomed to. She suggests that survival lies not in the endless definition of one's place in the world, but in its recognition and a loving, even fearing, homage.

  12. Pulmonary venous flow index as a predictor of pulmonary vascular resistance variability in congenital heart disease with increased pulmonary flow: a comparative study before and after oxygen inhalation.

    Science.gov (United States)

    Rivera, Ivan Romero; Mendonça, Maria Alayde; Andrade, José Lázaro; Moises, Valdir; Campos, Orlando; Silva, Célia Camelo; Carvalho, Antonio Carlos

    2013-09-01

    There is no definitive and reliable echocardiographic method for estimating the pulmonary vascular resistance (PVR) to differentiate persistent vascular disease from dynamic pulmonary hypertension. The aim of this study was to analyze the relationship between the pulmonary venous blood flow velocity-time integral (VTIpv) and PVR. Eighteen patients (10 females; 4 months to 22 years of age) with congenital heart disease and left to right shunt were studied. They underwent complete cardiac catheterization, including measurements of the PVR and Qp:Qs ratio, before and after 100% oxygen inhalation. Simultaneous left inferior pulmonary venous flow VTIpv was obtained by Doppler echocardiography. The PVR decreased significantly from 5.0 ± 2.6 W to 2.8 ± 2.2 W (P = 0.0001) with a significant increase in the Qp:Qs ratio, from 3.2 ± 1.4 to 4.9 ± 2.4 (P = 0.0008), and the VTIpv increased significantly from 22.6 ± 4.7 cm to 28.1 ± 6.2 cm (P = 0.0002) after 100% oxygen inhalation. VTIpv correlated well with the PVR and Qp:Qs ratio (r = -0.74 and 0.72, respectively). Diagnostic indexes indicated a sensitivity of 86%, specificity of 75%, accuracy of 83%, a positive predictive value of 92% and a negative predictive value of 60%. The VTIpv correlated well with the PVR. The measurement of this index before and after oxygen inhalation may become a useful noninvasive test for differentiating persistent vascular disease from dynamic and flow-related pulmonary hypertension. © 2013, Wiley Periodicals, Inc.

  13. Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals.

    Science.gov (United States)

    Salgado, Ana Lúcia Farias de Azevedo; Carvalho, Luciana de; Oliveira, Ana Claudia; Santos, Virgínia Nascimento dos; Vieira, Jose Gilberto; Parise, Edison Roberto

    2010-01-01

    Due to its good correlation to glycemic clamp, HOMA-IR has been widely utilized as insulin resistance index in clinical and epidemiological studies involving non-alcoholic fatty liver disease carriers. However, values used for this parameter have shown large variability. To identify the HOMA-IR cut value that best distinguishes non-diabetic non-alcoholic fatty liver disease patients from a control group. One hundred sixteen non-alcoholic fatty liver disease patients were studied, diagnosed by clinical, biochemical, and liver image or biopsy criteria, and 88 healthy individuals, without any liver disease and testing for oral glucose tolerance within normality. These groups did not differ in age and gender. All were submitted to oral glucose tolerance test and blood samples were collected for glucose and insulin measurements by immunofluorometric method. HOMA-IR was calculated according to the formula: fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5. NAFLD patients showed higher insulin, glycemia, and HOMA-IR values than control group, even when excluding glucose intolerant and diabetes mellitus patients by their glycemic curves. HOMA-IR 75th percentile for control group was 1.78 and the best area under the curve index was obtained for HOMA-IR values of 2.0 [AUC= 0.840 (0.781-0.899 CI 95%), sensitivity (Se): 85%, specificity (Sp): 83%] while value 2.5 showed best specificity without important loss in sensitivity [AUC=0,831 (0.773-0.888) Se = 72%, Sp = 94%]. HOMA-IR values above or equal to 2.0 or 2.5 show enhanced diagnostic value in distinguishing non-alcoholic fatty liver disease carriers from control group individuals.

  14. Value of Predicting Pregnant Hypertension of Observing PI and RI of Placental Helicine Arteries by Colour Doppler%彩色多普勒检测孕妇子宫胎盘床螺旋动脉PI、RI预测妊高征价值

    Institute of Scientific and Technical Information of China (English)

    茅红卫; 凡利俊; 季平; 张新源

    2001-01-01

    目的本研究采用彩色多普勒检测孕妇子宫胎盘床螺旋动脉搏动指数(PI),阻力指数(RI),预测妊高征的发生、发展及预后。方法选择无慢性高血压,心、肝、肾合并症正常孕妇184例。分正常组154例,异常组30例。从孕32周开始每隔2~3周重复检测一次子宫胎盘床螺旋动脉PI、RI,测量5个以上形态一致的多普勒频谱,取平均PI、RI值。结果两组存在显著差异,异常组PI、RI明显高于正常组(P<0.01)。结论应用彩色多普勒测定子宫胎盘床螺旋动脉PI、RI来预测孕高征的发生、发展及预后具有临床应用价值。%Objective To observe pulsative index (PI), resistant index (RI) of placental helicine arteries by colour Doppler, analyses relation between PI, RI and developing of pregnant hypertension. Methods There were 184 healthy pregnant women, they were normal in cardial, hepatic, nephral function, without hypertension 154 cases in 184 women were normal pregnant course, but 30 cases were with pregnant hypertension, since 32 pregnant weeks,every 2 or 3 weeks, the arteries were examined, more 5 frequency spectrums with same appearance,average of PI, RI were calculated. Results There are signifiant difference, PI, RI of pregnant hypertension were higher than normal group (P<0.01). Conclusion It is valuable for the clinics to observe helicine arteries by colour Doppler to predict pregnant hypertention.

  15. The Correlation of Plasma Levels of Apelin-13 with Insulin Resistance Index and Plasma Leptin of Diabetic Male Rats after 8-Week Aerobic Exercise

    Directory of Open Access Journals (Sweden)

    Fahimeh Kazemi

    2015-09-01

    Full Text Available Abstract Background: The physiological role of apelin, an adipokine secreted by adipose tissue, in insulin resistance and type 2 diabetes has been identified. The aim of this study was to determine the correlation of plasma levels of apelin-13 with insulin resistance index (HOMA-IR and plasma leptin of diabetic male rats after 8-week aerobic exercise. Materials and Methods: Peresent study was an experimental study with animal model. Twenty eight diabetic male Wistar rats were divided into 3 groups: Non-diabetic (n=9, control diabetic (n=9 and trained diabetic (n=10. Type 2 diabetes was induced by intraperitoneal injection of nicotinamide and streptozotocin. The trained diabetic rat ran 8-week on treadmill progressively. After the training period, plasma levels of glucose, insulin, leptin and apelin-13 were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA and Pearson’s correlation were used for analyzing data. p<0.05 was considered to be statistically significant. Results: A significant decrease in plasma levels of glucose, insulin and leptin and HOMA-IR in trained diabetic vs control diabetic rats, a significant increase in plasma levels of apelin in trained diabetic vs non-diabetic and control diabetic rats and a significant negative correlation of plasma levels of apelin with HOMA-IR and plasma leptin in trained diabetic rats was observed. Conclusion: In present study, 8-week aerobic training by improvement of insulin sensitivity (decrease of HOMA-IR and plasma leptin increased plasma levels of apelin-13 in diabetic male rats.

  16. The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia.

    Science.gov (United States)

    Bonaccorso, Stefania; Sodhi, Monsheel; Li, Jiang; Bobo, William V; Chen, Yuejin; Tumuklu, Mevhibe; Theleritis, Christos; Jayathilake, Karuna; Meltzer, Herbert Y

    2015-08-01

    We tested the hypothesis that a common functional variant in brain-derived neurotrophic factor (BDNF), Val66Met, which has been shown to be associated with increased body mass index (BMI) in schizophrenia (SCZ) and schizoaffective disorder (SAD), is also associated with antipsychotic-induced weight gain in bipolar disorder (BPD). Association of Val66Met with other metabolic measures, including high- and low-density cholesterol, triglycerides, total cholesterol, fasting blood glucose, and hemoglobin A1c, was also tested. This was a 12-month, prospective, randomized trial of two atypical antipsychotic drugs (APDs) with moderate (risperidone) or high (olanzapine) risk to cause weight gain. Subjects were diagnosed as having BPD (n = 90) and SCZ or SAD (n = 76). BMI was significantly greater in all diagnoses for Met66 allele carriers at six months (p = 0.01). Met66 carriers with BPD showed a greater increase in the triglycerides/high-density (HDL) cholesterol ratio (p = 0.01), a key marker for metabolic syndrome related to insulin resistance, and log-triglycerides (p = 0.04), after three or six months of treatment. Met66 carriers had the greatest increase in log-triglycerides (p = 0.03) and triglycerides/HDL cholesterol ratio after three months of treatment with risperidone (p = 0.003), and the highest BMI at six months (p = 0.01). The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Refractive index and temperature-sensing characteristics of a cladding-etched thin core fiber interferometer

    Science.gov (United States)

    Wang, Weiying; Dong, Xinran; Chu, Dongkai; Hu, Youwang; Sun, Xiaoyan; Duan, Ji-An

    2018-05-01

    A high refractive index (RI) sensor based on an in-line Mach-Zehnder mode interferometer (MZI) is proposed. The sensor was realized by splicing a 2-cm length of cladding-etched thin core fiber (TCF) between two single mode fibers (SMFs). The TCF-structured MZI exhibited good fringe visibility as high as 15 dB in air and the high RI sensitivity attained a value of 1143.89 nm/RIU at a RI of 1.447. The experimental data revealed that the MZI has high RI sensitivity after HF etching realizing 2599.66 nm/RIU. Studies were performed on the temperature characteristics of the device. It is anticipated that this high RI sensor will be deployed in new and diverse applications in the chemical and biological fields.

  18. Optimal cutoff for the evaluation of insulin resistance through triglyceride-glucose index: A cross-sectional study in a Venezuelan population [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Juan Salazar

    2017-10-01

    Full Text Available Background: Insulin resistance (IR evaluation is a fundamental goal in clinical and epidemiological research. However, the most widely used methods are difficult to apply to populations with low incomes. The triglyceride-glucose index (TGI emerges as an alternative to use in daily clinical practice. Therefore the objective of this study was to determine an optimal cutoff point for the TGI in an adult population from Maracaibo, Venezuela. Methods: This is a sub-study of Maracaibo City Metabolic Syndrome Prevalence Study, a descriptive, cross-sectional study with random and multi-stage sampling. For this analysis, 2004 individuals of both genders ≥18 years old with basal insulin determination and triglycerides < 500 mg/dl were evaluated.. A reference population was selected according to clinical and metabolic criteria to plot ROC Curves specific for gender and age groups to determine the optimal cutoff point according to sensitivity and specificity.The TGI was calculated according to the equation: ln [Fasting triglyceride (mg / dl x Fasting glucose (mg / dl] / 2. Results: The TGI in the general population was 4.6±0.3 (male: 4.66±0.34 vs. female: 4.56±0.33, p=8.93x10-10. The optimal cutoff point was 4.49, with a sensitivity of 82.6% and specificity of 82.1% (AUC=0.889, 95% CI: 0.854-0.924. There were no significant differences in the predictive capacity of the index when evaluated according to gender and age groups. Those individuals with TGI≥4.5 had higher HOMA2-IR averages than those with TGI <4.5 (2.48 vs 1.74, respectively, p<0.001. Conclusions: The TGI is a measure of interest to identify IR in the general population. We propose a single cutoff point of 4.5 to classify individuals with IR. Future studies should evaluate the predictive capacity of this index to determine atypical metabolic phenotypes, type 2 diabetes mellitus and even cardiovascular risk in our population.

  19. Improving Forecast Skill by Assimilation of AIRS Cloud Cleared Radiances RiCC

    Science.gov (United States)

    Susskind, Joel; Rosenberg, Robert I.; Iredell, Lena

    2015-01-01

    ECMWF, NCEP, and GMAO routinely assimilate radiosonde and other in-situ observations along with satellite IR and MW Sounder radiance observations. NCEP and GMAO use the NCEP GSI Data Assimilation System (DAS).GSI DAS assimilates AIRS, CrIS, IASI channel radiances Ri on a channel-by-channel, case-by-case basis, only for those channels i thought to be unaffected by cloud cover. This test excludes Ri for most tropospheric sounding channels under partial cloud cover conditions. AIRS Version-6 RiCC is a derived quantity representative of what AIRS channel i would have seen if the AIRS FOR were cloud free. All values of RiCC have case-by-case error estimates RiCC associated with them. Our experiments present to the GSI QCd values of AIRS RiCC in place of AIRS Ri observations. GSI DAS assimilates only those values of RiCC it thinks are cloud free. This potentially allows for better coverage of assimilated QCd values of RiCC as compared to Ri.

  20. Acid detergent lignin, lodging resistance index, and expression of the caffeic acid O-methyltransferase gene in brown midrib-12 sudangrass.

    Science.gov (United States)

    Li, Yuan; Liu, Guibo; Li, Jun; You, Yongliang; Zhao, Haiming; Liang, Huan; Mao, Peisheng

    2015-09-01

    Understanding the relationship between acid detergent lignin (ADL) and lodging resistance index (LRI) is essential for breeding new varieties of brown midrib (bmr) sudangrass (Sorghum sudanense (Piper) Stapf.). In this study, bmr-12 near isogenic lines and their wild-types obtained by back cross breeding were used to compare relevant forage yield and quality traits, and to analyze expression of the caffeic acid O-methyltransferase (COMT) gene using quantitative real time-PCR. The research showed that the mean ADL content of bmr-12 mutants (20.94 g kg(-1)) was significantly (P bmr-12 mutants (0.29) was significantly (P bmr-12 materials (r = -0.44, P > 0.05). Sequence comparison of the COMT gene revealed two point mutations present in bmr-12 but not in the wild-type, the second mutation changed amino acid 129 of the protein from Gln (CAG) to a stop codon (UAG). The relative expression level of COMT gene was significantly reduced, which likely led to the decreased ADL content observed in the bmr-12 mutant.

  1. Coronary physiological assessment combining fractional flow reserve and index of microcirculatory resistance in patients undergoing elective percutaneous coronary intervention with grey zone fractional flow reserve.

    Science.gov (United States)

    Niida, Takayuki; Murai, Tadashi; Yonetsu, Taishi; Kanaji, Yoshihisa; Usui, Eisuke; Matsuda, Junji; Hoshino, Masahiro; Araki, Makoto; Yamaguchi, Masao; Hada, Masahiro; Ichijyo, Sadamitsu; Hamaya, Rikuta; Kanno, Yoshinori; Isobe, Mitsuaki; Kakuta, Tsunekazu

    2018-03-08

    The aim of this study is to investigate the association between fractional flow reserve (FFR) values and change in coronary physiological indices after elective percutaneous coronary intervention (PCI). Decision making for revascularization when FFR is 0.75-0.80 is controversial. A retrospective analysis was performed of 296 patients with stable angina pectoris who underwent physiological examinations before and after PCI. To investigate the differences of coronary flow improvement between territories with low-FFR (zone FFR (0.75-0.80), serial changes in physiological indices including mean transit time (Tmn), coronary flow reserve (CFR), and index of microcirculatory resistance (IMR) were compared between these two groups. Compared to low-FFR territories, grey-zone FFR territories showed significantly lower prevalence of Tmn shortening, CFR improvement, and decrease in IMR (Tmn shorting, 63.9% vs. 87.0%, P 51.3% vs. 63.3%, P = .040) and lower extent of their absolute changes (Tmn shorting, 0.06 (-0.03 to 0.16) vs. 0.22 (0.07-0.45), P zone FFR. Physiological assessment combining FFR and IMR may help identify patients who may benefit by PCI, particularly those in the grey zone. © 2018 Wiley Periodicals, Inc.

  2. Development and assessment of users' satisfaction with the systemic lupus erythematosus disease activity index 2000 responder index-50 website.

    Science.gov (United States)

    Touma, Zahi; Gladman, Dafna D; MacKinnon, Anne; Carette, Simon; Abu-Shakra, Mahmoud; Askanase, Anca; Nived, Ola; Hanly, John G; Landolt-Marticorena, Carolina; Tam, Lai-Shan; Toloza, Sergio; Nikpour, Mandana; Riddell, Claire; Steiman, Amanda; Eder, Lihi; Haddad, Amir; Barber, Claire; Urowitz, Murray B

    2013-01-01

    To describe the development of the Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index-50 (S2K RI-50) Website (www.s2k-ri-50.com) and to assess satisfaction with its training and examination modules among rheumatologists and rheumatology fellows. The development of the Website occurred in 3 phases. The first was a deployment phase that consisted of preparing the site map along with its content. The content included the S2K RI-50 training manual, the tests and corresponding question bank, and the online adaptive training module, along with the extensive site testing. The second phase included the participation of rheumatologists and trainees who completed the Website modules. The third was a quality assurance phase in which an online survey was developed to determine the satisfaction level of its users. Further modifications were implemented per participants' recommendations. The site has been online since it was registered in September 2010. Fourteen rheumatologists and rheumatology trainees from different centers reviewed and completed the material contained in the Website. The survey revealed acceptance among rheumatologists for the Website's content, design, and presentation. The Website was rated as user-friendly and useful in familiarizing investigators with the S2K RI-50. After completion of the training and examination modules, participants reported a suitable level of preparation to implement the S2K RI-50 in clinical trials and research settings in a timely manner. The Website includes training and examination modules that familiarize rheumatologists with the S2K RI-50 and assesses their competence to use the index. This prepares them for the use of the S2K RI-50 in clinical trials and research settings.

  3. Influence of an external gas puff on the RI-mode confinement properties in TEXTOR

    International Nuclear Information System (INIS)

    Kalupin, D.

    2002-06-01

    An actual subject of experimental and theoretical studies in present day fusion research is the development of an operational scenario combining simultaneously high confinement, with at least H-mode quality, and high densities, around or above the empirical Greenwald limit. Recently, this subject was studied in TEXTOR radiative improved (RI) mode discharges, in which the seeding of a small amount of impurities is helpful in a transition to the improved confinement stage. It was found that by the careful tailoring of external fuelling and optimisation of the wall conditions it is possible to maintain the H-mode or even higher quality confinement at densities much above Greenwald density limit. However, more intense fuelling, aimed to extend maximal achievable densities, led to the progressive confinement deterioration. The theory explains the transition to the RI-mode as a bifurcation into the stage where the transport governed by the ion temperature gradient (ITG) instability is significantly reduced due to a high density gradient and high value of the effective charge. The numerical studies of an influence of the gas puff intensity on confinement properties of plasma, done with the help of the 1-D transport code RITM, show that the same theory can be used for an explanation of the confinement rollover triggered by a strong gas puff. The code was modified in order to simulate the effect of the gas puff on the confinement properties. The anomalous transport coefficients in the plasma core include contributions from the ITG and dissipative trapped electron (DTE) instabilities. The transport at the plasma edge under RI-mode conditions might be described by the electrostatic turbulence caused by electric currents in the scrape-off layer of the limiter. The present computations show that this assumption for the edge transport does not allow the modeling of an effect of the gas puff intensity on the profiles evolution in agreement with experimental observations. The

  4. Eco RI RFLP in the human IGF II gene

    Energy Technology Data Exchange (ETDEWEB)

    Cocozza, S; Garofalo, S; Robledo, R; Monticelli, A; Conti, A; Chiarotti, L; Frunzio, R; Bruni, C B; Varrone, S

    1988-03-25

    The probe was a 500 bp cDNA containing exons 2-3 and 4 of the human IGF II gene. The clone was isolated by screening a human liver cDNA library with synthetic oligonucleotides. Eco RI digestion of genomic DNA and hybridization with the IGF II probe detects a two allele polymorphism with allelic fragments of 13.5 kb and 10.5 kb. The frequency was studied 38 unrelated Caucasians: Human IGF II gene was localized on the short arm of chromosome 11 (p15) by in situ hybridization. Codominant segregation was observed in 2 Caucasian families (10 individuals).

  5. Eesti estamp sisepaguluses : graafikatriennaal / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2004-01-01

    Graafikute grupinäitused G-galeriis (kuraator Loit Jõekalda, osalevad Vive Tolli, Vello Vinn, Silvi Liiva, Raul Meel, Mare Vint, Jüri Kass, Ülle Marks, Maria-Kristiina Ulas) kuni 25. IX, Aatriumi galeriis kuni 23. IX, Soome Instituudis kuni 30. IX, Vappu Thurlowi kureeritud näitus "Lähenemised" Estonia kontserdisaalis kuni 15. X, Virge Jõekalda näitus "Vaikus" Ungari Instituudis kuni 27. IX, Loit Jõekalda näitus "Must ja valge" galeriis 36 kuni 19. IX

  6. Uncladded sensing fiber for refractive index measurement

    International Nuclear Information System (INIS)

    Bhardwaj, V.; Gangwar, R. K.; Pathak, A. K.; Singh, V. K.

    2016-01-01

    The formation of chemically etched optical fiber for use in refractive index sensor is addressed. This presented design of a refractive index (RI) sensor is based on recording the power loss exhibited by radiation propagating through an etched multimode fiber (MMF) immersed in the liquid under study. The decreasing diameters of fibers are found to be strongly dependent on the temperature and etchant composition. This experiment was performed for different unclad etched fibers for same sensing length and the RI changes from 1.33 RIU to 1.38 RIU. When the multimode fiber (MMF) is etched for 12 hours the sensitivity of the sensor is approximately 204.25dBm/RIU, which is larger than without etched fiber having sensitivity 127.2dBm/RIU.

  7. Uncladded sensing fiber for refractive index measurement

    Science.gov (United States)

    Bhardwaj, V.; Gangwar, R. K.; Pathak, A. K.; Singh, V. K.

    2016-05-01

    The formation of chemically etched optical fiber for use in refractive index sensor is addressed. This presented design of a refractive index (RI) sensor is based on recording the power loss exhibited by radiation propagating through an etched multimode fiber (MMF) immersed in the liquid under study. The decreasing diameters of fibers are found to be strongly dependent on the temperature and etchant composition. This experiment was performed for different unclad etched fibers for same sensing length and the RI changes from 1.33 RIU to 1.38 RIU. When the multimode fiber (MMF) is etched for 12 hours the sensitivity of the sensor is approximately 204.25dBm/RIU, which is larger than without etched fiber having sensitivity 127.2dBm/RIU.

  8. Uncladded sensing fiber for refractive index measurement

    Energy Technology Data Exchange (ETDEWEB)

    Bhardwaj, V., E-mail: bhardwajphyism@gmail.com; Gangwar, R. K.; Pathak, A. K.; Singh, V. K. [Department of Applied Physics Indian School of Mines Dhanbad, Jharkhand (India)

    2016-05-06

    The formation of chemically etched optical fiber for use in refractive index sensor is addressed. This presented design of a refractive index (RI) sensor is based on recording the power loss exhibited by radiation propagating through an etched multimode fiber (MMF) immersed in the liquid under study. The decreasing diameters of fibers are found to be strongly dependent on the temperature and etchant composition. This experiment was performed for different unclad etched fibers for same sensing length and the RI changes from 1.33 RIU to 1.38 RIU. When the multimode fiber (MMF) is etched for 12 hours the sensitivity of the sensor is approximately 204.25dBm/RIU, which is larger than without etched fiber having sensitivity 127.2dBm/RIU.

  9. Highly Sensitive Refractive Index Sensor Based on a Cladding-Etched Thin-Core Fiber Sandwiched between Two Single-Mode Fibers

    International Nuclear Information System (INIS)

    Xu Ben; Li Yi; Dong Xin-Yong; Jin Shang-Zhong; Zhang Zai-Xuan

    2012-01-01

    A refractive index (RI) sensor based on a cladding-etched thin-core single-mode fiber (TCSMF) sandwiched between two single-mode fibers is demonstrated. The experimental results show that the sensitivity, within the RI range of 1.333–1.340, is enhanced at least 6 times by etching. It increases with the surrounding RI and reaches 857.5 nm/RIU at RI of 1.3684, and it can be expected to be higher with the decrease of the cladding diameter of the TCSMF

  10. ri Talvet maailmaluule tõlgendajana / Jüri Talvet’s Interpretations of World Poetry

    OpenAIRE

    Lauri Pilter

    2016-01-01

    Teesid: Tartu Ülikooli maailmakirjanduse professori, luuletaja, kirjandusteadlase ja hispaaniakeelse kirjanduse spetsialisti Jüri Talveti tõlketegevuse viljade hulka kuulub luulet ja proosat nii sajandeid vanast Hispaania klassikast kui ka 20. sajandil või tänapäeval romaani keeltes või inglise keeles loodud teostest. Käesolev artikkel keskendub sellele, kuidas professor Talvet on tõlgendanud luule ja poeetika, kuid ka kirjandusajaloo, iseäranis barokk-kirjanduse alaseid küsimusi oma kirjandu...

  11. The Asia-RiCE activity with data cube

    Science.gov (United States)

    Oyoshi, K.; Sobue, S.; LE Toan, T.; Lam, N. D.

    2017-12-01

    The Asia-RiCE initiative (http://www.asia-rice.org) has been organized to enhance rice production estimates through the use of Earth observation satellites data, and seeks to ensure that Asian rice crops are appropriately represented within GEO Global Agriculture Monitoring (GEO-GLAM) to support FAO Agriculture Market Information System (FAO-AMIS). Asia-RiCE is composed of national teams that are actively contributing to the Crop Monitor for AMIS and developing technical demonstrations of rice crop monitoring activities using both Synthetic Aperture Radar (SAR) data (Radarsat-2 from 2013; Sentinel-1 and ALOS-2 from 2015.From 2016 after the successful rice crop area and growing estimation using SAR in a technical demonstration site (provincial level), wall-to-wall (national scale) excurse as phase 2 has been implemented in Vietnam and Indonesia in cooperation with ministry of agriculture and space agencies. This paper reports this year activity of 2017 accomplishment and way forward, especially for analysis ready data (ARD) definition of SAR to ingest to CEOS data cube to provide national scale service in Vietnam and Indonesia.

  12. Longitudinal prospective observational type study about determinants of renal resistive index variations in chronic renal failure patients treated with conventional medical and dietetic therapy

    Directory of Open Access Journals (Sweden)

    Simone Brardi

    2017-12-01

    Full Text Available Objective: This longitudinal prospective observational type study was conceived with the aim to examine the impact on renal resistive index (RRI of the variables that we can manipulate with therapeutic and or dietetic interventions in a chronic kidney disease population in order to known which of these variables was statistically related to changes in RRI and therefore could become the object of the greatest therapeutic effort. Material and methods: This study was undertaken between May 2016 to May 2017 in the outpatient nephrology and urology clinic of San Donato Hospital in Arezzo. The study population (84 patients: 47 males and 37 females was randomly selected among the chronic kidney patients (with various degrees of renal impairment affected by hypertension and or diabetes mellitus. After a comprehensive medical examination these patients were submitted to determination of serum creatinine, glycated hemoglobin, 24-hour urinary albumin excretion and finally renal Doppler ultrasonography. Then the patients were submitted to a full therapeutic and dietetic intervention to ameliorate the renal impairment by a wide range of actions and after on average a one-year interval were submitted again to a new medical examination and a second determination of serum creatinine, glycated hemoglobin, 24-hour urinary albumin excretion and a new renal Doppler ultrasonography too. Results: The comparison between basal and final data revealed a slight reduction in the mean of bilateral renal resistance indices (Delta RRI: -0.0182 ± 0.08, associated to a slight increase in the mean glomerular filtration rate (Delta GFR: 0.8738 ± 10.95 ml/min/1.73 m2, a reduction in mean body weight (Delta weight: -1.9548 ± 5.26 Kg and mean BMI (Delta BMI: -0.7643 ± 2.10 Kg/m2 as well as a reduction in the mean systolic blood pressure (Delta systolic blood pressure: -8.8333 ± 25.19 mmHg. Statistical analysis showed statistically significant correlations (p < 0.05 between

  13. Longitudinal prospective observational type study about determinants of renal resistive index variations in chronic renal failure patients treated with conventional medical and dietetic therapy.

    Science.gov (United States)

    Brardi, Simone; Cevenini, Gabriele; Giovannelli, Vanni; Romano, Giuseppe

    2017-12-31

    This longitudinal prospective observational type study was conceived with the aim to examine the impact on renal resistive index (RRI) of the variables that we can manipulate with therapeutic and or dietetic interventions in a chronic kidney disease population in order to known which of these variables was statistically related to changes in RRI and therefore could become the object of the greatest therapeutic effort. This study was undertaken between May 2016 to May 2017 in the outpatient nephrology and urology clinic of San Donato Hospital in Arezzo. The study population (84 patients: 47 males and 37 females) was randomly selected among the chronic kidney patients (with various degrees of renal impairment) affected by hypertension and or diabetes mellitus. After a comprehensive medical examination these patients were submitted to determination of serum creatinine, glycated hemoglobin, 24-hour urinary albumin excretion and finally renal Doppler ultrasonography. Then the patients were submitted to a full therapeutic and dietetic intervention to ameliorate the renal impairment by a wide range of actions and after on average a one-year interval were submitted again to a new medical examination and a second determination of serum creatinine, glycated hemoglobin, 24-hour urinary albumin excretion and a new renal Doppler ultrasonography too. The comparison between basal and final data revealed a slight reduction in the mean of bilateral renal resistance indices (Delta RRI: -0.0182 ± 0.08), associated to a slight increase in the mean glomerular filtration rate (Delta GFR: 0.8738 ± 10.95 ml/min/1.73 m2), a reduction in mean body weight (Delta weight: -1.9548 ± 5.26 Kg) and mean BMI (Delta BMI: -0.7643 ± 2.10 Kg/m2) as well as a reduction in the mean systolic blood pressure (Delta systolic blood pressure: -8.8333 ± 25.19 mmHg). Statistical analysis showed statistically significant correlations (p chronic renal failure and as a valuable tool to drive the clinical

  14. Use of AFLP marker system on sugarcane somaclones to study their resistance to rust

    OpenAIRE

    María Ileana Oloriz; Luis Rojas; Víctor Gil; Milady Mendoza; Ariel Arencibia; Elva Rosa Carmona; Elio Jiménez

    2002-01-01

    AFLPs (amplified fragment length polymorphism) was carried out from genomic DNA of five rust resistant sugar cane somaclons and their susceptible donor, Saccharum officinarum var B 4362, using three combinations of primers (EcoRI/aca: MseI/acc; EcoRI/aca: MseI/atg and EcoRI/aca: MseI/agg). Six polymorphic bands were obtained, two of these only appeared in the resistant genotypes, which are probably DNA sequences, related to rust resistance locus. These fragments have been cloned to study thei...

  15. Optical fibre cavity ring down measurement of refractive index with a microchannel drilled by femtosecond laser

    Science.gov (United States)

    Zhou, Kaiming; Webb, David; Mou, Chengbo; Farries, Mark; Hayes, Neil; Bennion, Ian

    2009-10-01

    μA microchannel was inscribed in the fibre of a ring cavity which was constructed from two 0.1%:99.9% couplers and a 10m fibre loop. Cavity ring down spectroscopy (CRDS) was used to measure the refractive index (RI) of gels infused into the microchannel with high resolution. The ring down time discloses a nonlinear increase with respect to the RI of the gel and sensitivity up to 300μs/RI unit (RIU) and resolution of 5×10-4 were obtained.

  16. High-molecular-weight adiponectin is selectively reduced in women with polycystic ovary syndrome independent of body mass index and severity of insulin resistance.

    LENUS (Irish Health Repository)

    O'Connor, A

    2010-03-01

    Context: High-molecular-weight (HMW) adiponectin contributes to insulin resistance (IR), which is closely associated with the pathophysiology of polycystic ovary syndrome (PCOS). Abnormalities in adipocyte function have been identified in PCOS and potentially contribute to lower adiponectin concentrations. Objective: Our objective was to determine which variables in plasma and adipose tissue influence HMW adiponectin in a well characterized cohort of women with PCOS. Design: This was a cross-sectional study. Settings and Participants: A teaching hospital. Women with PCOS (n = 98) and body mass index (BMI)-matched controls (n = 103) (including 68 age-, BMI-, and IR-matched pairs). Interventions: A standard 75-g oral glucose tolerance test was performed for each participant. Subcutaneous adipose tissue samples were taken by needle biopsy for a subset of PCOS women (n = 9) and controls (n = 8). Main Outcome Measures: Serum levels of HMW adiponectin and their relation to indices of insulin sensitivity, body composition, and circulating androgens as well as adipose tissue expression levels of ADIPOQ, TNFalpha, PPARgamma, and AR were assessed. Results: HMW adiponectin was significantly lower in women with PCOS compared with both BMI- and BMI- and IR-matched controls (P = 0.009 and P = 0.027, respectively). Although BMI and IR were the main predictors of HMW adiponectin, an interaction between waist to hip ratio and plasma testosterone contributed to its variance (P = 0.026). Adipose tissue gene expression analysis demonstrated that AR and TNFalpha (P = 0.008 and P = 0.035, respectively) but not ADIPOQ mRNA levels were increased in PCOS compared with controls. Conclusions: HMW adiponectin is selectively reduced in women with PCOS, independent of BMI and IR. Gene expression analysis suggests that posttranscriptional\\/translational modification contributes to reduced HMW adiponectin in PCOS.

  17. Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarction.

    Science.gov (United States)

    Cuculi, Florim; De Maria, Giovanni Luigi; Meier, Pascal; Dall'Armellina, Erica; de Caterina, Alberto R; Channon, Keith M; Prendergast, Bernard D; Choudhury, Robin P; Choudhury, Robin C; Forfar, John C; Kharbanda, Rajesh K; Banning, Adrian P

    2014-11-04

    Invasive assessment of coronary physiology (IACP) offers important prognostic insights in ST-segment elevation myocardial infarction (STEMI) but the dynamics of coronary recovery are poorly understood. This study sought to examine the evolution of coronary flow reserve (CFR), index of microcirculatory resistance (IMR), ratio of distal coronary pressure (Pd) to mean aortic pressure (Pa), and fractional flow reserve (FFR) in patients undergoing primary percutaneous coronary intervention (PPCI). 82 patients with STEMI underwent IACP at PPCI. Repeat IACP was performed in 61 patients (74%) at day 1 and in 46 patients (56%) at 6 months. Contrast-enhanced cardiac magnetic resonance imaging (CMR) was performed in 45 patients (55%) at day 1 and in 41 patients (50%) at 6 months. Changes in IACP were compared between patients with and without microvascular obstruction (MVO) on CMR. MVO was present in 21 of 45 patients (47%). Patients with MVO had lower CFR at PPCI and day 1 (p < 0.05) and a trend toward higher IMR values (p = 0.07). At 6 months, CFR and IMR were not significantly different between the groups. Baseline flow and Pd/Pa remained stable over time but FFR reduced significantly between PPCI and 6 months (p = 0.008); this reduction was mainly observed in patients with MVO (p = 0.006) but not in those without MVO (p = 0.21). In PPCI-treated patients with STEMI, coronary microcirculation begins to recover within 24 h and recovery progresses further by 6 months. FFR significantly reduces from baseline to 6 months. The presence of MVO indicates a highly dysfunctional microcirculation. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  18. Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) as Markers of Insulin Resistance and Metabolic Associated Disturbances in Young Argentine Women with Polycystic Ovary Syndrome.

    Science.gov (United States)

    Abruzzese, Giselle A; Cerrrone, Gloria E; Gamez, Juan M; Graffigna, Mabel N; Belli, Susana; Lioy, Gustavo; Mormandi, Eduardo; Otero, Patricia; Levalle, Oscar A; Motta, Alicia B

    2017-01-01

    Polycystic ovary syndrome (PCOS) is an endocrine disorder. PCOS women are at high risk of developing insulin resistance (IR) and cardiovascular disorders since young age. We aimed to study the reliability of lipid accumulation product (LAP) and visceral adiposity index (VAI) as markers of metabolic disturbances (MD) associated with IR in young reproductive aged PCOS patients. We also evaluated the association between LAP and VAI and the presence of hyperandrogenism. In a cross-sectional study, 110 PCOS patients and 88 control women (18-35 years old) were recruited. PCOS patients were divided into 2 groups, as hyperandrogenic and non-hyperandrogenic considering the signs of hyperandrogenism (clinical or biochemical). Anthropometric measurements were taken and blood samples collected. Metabolic and anthropometric characteristics and their association with IR and associated MD were evaluated and LAP and VAI were calculated. LAP and VAI were compared with TC/HDL-c and TG/HDL-c to define the best markers of MD in this population. Independently of the phenotype, young PCOS patients showed high IR and dyslipidemia. Both LAP and VAI showed to be more effective markers to assess MD and IR in these young women than TG/HDL-c or TC/HDL-c [cut-off values: LAP: 18.24 (sensitivity: 81.43% specificity: 73.49%), positive predictive value (PPV): 75.0%, negative predictive value (NPV): 77.27%, VAI: 2.19 (sensitivity: 81.16% specificity: 72.15% PPV: 74.65% NPV: 72.22%)]. LAP and VAI are representative markers to assess MD associated with IR in young PCOS patients. All PCOS patients, independently of their androgenic condition, showed high metabolic risk. © Georg Thieme Verlag KG Stuttgart · New York.

  19. Refractive index sensor based on lateral-offset of coreless silica interferometer

    Science.gov (United States)

    Baharin, Nur Faizzah; Azmi, Asrul Izam; Abdullah, Ahmad Sharmi; Mohd Noor, Muhammad Yusof

    2018-02-01

    A compact, cost-effective and high sensitivity fiber interferometer refractive index (RI) sensor based on symmetrical offset coreless silica fiber (CSF) configuration is proposed, optimized and demonstrated. The sensor is formed by splicing a section of CSF between two CSF sections in an offset manner. Thus, two distinct optical paths are created with large index difference, the first path through the connecting CSF sections and the second path is outside the CSF through the surrounding media. RI sensing is established from direct interaction of light with surrounding media, hence high sensitivity can be achieved with a relatively compact sensor length. In the experimental work, a 1.5 mm sensor demonstrates RI sensitivity of 750 nm/RIU for RI range between 1.33 and 1.345. With the main attributes of high sensitivity and compact size, the proposed sensor can be further developed for related applications including blood diagnosis, water quality control and food industries.

  20. A heavy ion linac complex for RI beams

    International Nuclear Information System (INIS)

    Arai, Shigeaki

    1995-01-01

    A heavy ion linac complex for RI-beams has been under construction since fiscal year 1992 at INS. The linac complex comprises following accelerating structures: a 25.5-MHz split coaxial RFQ (SCRFQ), a 51-MHz interdigital-H (IH) linac, and a 25.5-MHz rebuncher cavity. The SCRFQ with modulated vanes accelerates ions with a charge-to-mass ratio (q/A) greater than 1/30 from 2 to 170 keV/u. The IH linac comprises four cavities and three magnetic quadrupole triplets placed between cavities, accelerates ions with q/A≥1/10, and varies the output energy continuously in the range 0.17 ∼1.05 MeV/u. The rebuncher cavity with six accelerating gaps is a double coaxial λ/4 resonator, and the total accelerating voltage is 200 kV. (author)

  1. Endurance test on IR rig for RI production

    International Nuclear Information System (INIS)

    Chung, Heung June; Youn, Y. J.; Han, H. S.; Hong, S. B.; Cho, Y. G.; Ryu, J. S.

    2000-12-01

    This report presents the pressure drop, vibration and endurance test results for IR rig for RI production which were desigened and fabricated by KAERI. From the pressure drop test results, it is noted that the flow rate through the IR rig corresponding to the pressure drop of 200 kPa is measured to be about 3.12 kg/sec. Vibration frequency for the IR rig ranges from 13 to 17 Hz. RMS(Root Mean Square) displacement for the IR rig is less than 30 μm, and the maximum displacement is less than 110μm. These experimental results show that the design criteria of IR rig meet the HANARO limit conditions. Endurance test results show that the appreciable fretting wear for the IR rig does not occur, however tiny trace of wear between contact points is observed

  2. Exchangeability of RI image data and its effect

    Energy Technology Data Exchange (ETDEWEB)

    Kojima, K; Hiraki, T [Kanazawa Univ. (Japan). School of Paramedicine; Nakajima, K; Hisada, K; Yamada, M

    1981-10-01

    Of RI image data processing machines, the exchangeability of data between the VIP-450 system (Ohio-Nuclear Inc.) and the DAP-5000N system (Toshiba Co.) was examined. The exchangeability requires uniformity of arrangement of bits and the data sequence between the machines. Otherwise, the form of memory of either machine should be changed. The exchangeability of data between the machines would have the following advantages: characteristic programs of each machine can be used for the same data, producing more valuable information. Data collection can be performed by any machine, increasing the efficiency of examination. It is not necessary to provide all machines with special attachments. It permits data input into large machines or minicomputers in the development of programs.

  3. Exchangeability of RI image data and its effect

    International Nuclear Information System (INIS)

    Kojima, Kazuhiko; Hiraki, Tatsunosuke; Nakajima, Kenichi; Hisada, Kinichi; Yamada, Masato.

    1981-01-01

    Of RI image data processing machines, the exchangeability of data between the VIP-450 system (Ohio-Nuclear Inc.) and the DAP-5000N system (Toshiba Co.) was examined. The exchangeability requires uniformity of arrangement of bits and the data sequence between the machines. Otherwise, the form of memory of either machine should be changed. The exchangeability of data between the machines would have the following advantages: characteristic programs of each machine can be used for the same data, producing more valuable information. Data collection can be performed by any machine, increasing the efficiency of examination. It is not necessary to provide all machines with special attachments. It permits data input into large machines or minicomputers in the development of programs. (Chiba, N.)

  4. A scalable implementation of RI-SCF on parallel computers

    International Nuclear Information System (INIS)

    Fruechtl, H.A.; Kendall, R.A.; Harrison, R.J.

    1996-01-01

    In order to avoid the integral bottleneck of conventional SCF calculations, the Resolution of the Identity (RI) method is used to obtain an approximate solution to the Hartree-Fock equations. In this approximation only three-center integrals are needed to build the Fock matrix. It has been implemented as part of the NWChem package of portable and scalable ab initio programs for parallel computers. Utilizing the V-approximation, both the Coulomb and exchange contribution to the Fock matrix can be calculated from a transformed set of three-center integrals which have to be precalculated and stored. A distributed in-core method as well as a disk based implementation have been programmed. Details of the implementation as well as the parallel programming tools used are described. We also give results and timings from benchmark calculations

  5. Experience of Ko-Ri Unit 1 water chemistry

    International Nuclear Information System (INIS)

    Tae Il Lee

    1983-01-01

    The main focus is placed on operational experience in secondary system water chemistry (especially the steam generator) of the Ko-Ri nuclear power plant Unit 1, Republic of Korea, but primary side chemistry is also discussed. The major concern of secondary water chemistry in a PWR is that the condition of the steam generator be well maintained. Full flow deep bed condensate polishers have recently been installed and operation started in July 1982. Boric acid treatment of the steam generator was stopped and only the all volatile treatment method was used thereafter. A review of steam generator integrity, the chemistry control programme, secondary water quality, etc. is considered to be of great value regarding the operation of Unit 1 and future units now under startup testing or construction in the Republic of Korea. (author)

  6. Data of evolutionary structure change: 1DEAA-2RI1A [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DEAA-2RI1A 1DEA 2RI1 A A -MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLG.../line> ASP CA 284 PHE CA 347 SER CA 228 1DEA... A 1DEAA ALVEMHKAGQVSFK 1DEA A 1DEAA GLU CA 160 ASP CA 224 VAL CA 284 1DEA

  7. Tüüri ava(sta)mas, kuid mitte ainult / Igor Garšnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2011-01-01

    Kahest kontserdist Estonia kontserdisaalis - 4. märtsil ERSO ja Herbert Schuch (klaver) Olari Eltsi dirigeerimisel, kavas Tüüri Sümfoonia nr 8, Pärdi "Nekroloog" ja Ullmanni Klaverikontsert ning 10. märtsil Erkki-Sven Tüüri autorikontsert, kus esinesid Eesti Filharmoonia Kammerkoor ja Sinfonietta Riga Daniel Reussi juhatusel

  8. 77 FR 39395 - Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI

    Science.gov (United States)

    2012-07-03

    ...-AA08 Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI AGENCY... Tall Ships Festival 2012. DATES: This rule is effective from July 6, 2012 until July 10, 2012... ``Special Local Regulations: Ocean State Tall Ships Festival 2012, Narragansett Bay, RI'' in the Federal...

  9. 77 FR 43514 - Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI

    Science.gov (United States)

    2012-07-25

    ...-AA01 Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI AGENCY: Coast Guard, DHS... Narragansett Bay, Rhode Island, and adding an offshore anchorage in Rhode Island Sound south of Brenton Point... rulemaking (NPRM) entitled ``Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI,'' in the...

  10. 77 FR 28253 - Safety Zone; America's Cup World Series, East Passage, Narragansett Bay, RI

    Science.gov (United States)

    2012-05-14

    ...-AA00 Safety Zone; America's Cup World Series, East Passage, Narragansett Bay, RI AGENCY: Coast Guard... navigable waters of the East Passage, Narragansett Bay, Rhode Island, during the America's Cup World Series... rulemaking (NPRM) entitled ``Safety Zones; America's Cup World Series, East Passage, Narragansett Bay, RI...

  11. Elagu eesti energia : Jaan ja Jüri Ojaver, Paul Rodgers / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2001-01-01

    Paul Rodgersi, Jüri ja Jaan Ojaveri ühisnäitusest "Koostöö" Rakvere Kesklinna galeriis. P. Rodgersilt ja Jüri Ojaverilt on väljas Viinist "Eesti energia" näituselt naasnud tööd, Jaan Ojaverilt minimalistlikud tööriistad-objektid

  12. Kas e-äri võrdub pankrotiga / Priit Vaikmaa

    Index Scriptorium Estoniae

    Vaikmaa, Priit

    2001-01-01

    E-äride pankrotilaine aastal 2000. Firmadevaheline äri internetis - B2B (business-to-business). B2B ärikeskkondade kodulehekülgede aadressid. B2B ja e-äri lahenduste pakkujad Eestis. Diagramm: B2B e-kommertsi prognoositud käive 2004.a.

  13. 76 FR 18812 - Submission for Review: RI 30-10, Disabled Dependent Questionnaire

    Science.gov (United States)

    2011-04-05

    ... OFFICE OF PERSONNEL MANAGEMENT Submission for Review: RI 30-10, Disabled Dependent Questionnaire... Dependent Questionnaire. As required by the Paperwork Reduction Act of 1995 (Pub. L. 104-13, 44 U.S.C... (202) 606-0910. SUPPLEMENTARY INFORMATION: The RI 30-10, Disabled Dependent Questionnaire, is used to...

  14. 76 FR 36582 - Submission for Review: Disabled Dependent Questionnaire, RI 30-10

    Science.gov (United States)

    2011-06-22

    ... OFFICE OF PERSONNEL MANAGEMENT Submission for Review: Disabled Dependent Questionnaire, RI 30-10... Dependent Questionnaire. As required by the Paperwork Reduction Act of 1995 (Pub. L. 104-13, 44 U.S.C.... SUPPLEMENTARY INFORMATION: RI 30-10, Disabled Dependent Questionnaire, is used to collect sufficient information...

  15. Linnapea, keda rõõmustab titekisa / Jüri Ratas ; interv. Riina Luik

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2006-01-01

    Tallinna linnapea vastab küsimustele, mis puudutavad tema suhtumist opositsiooni kriitikasse, linna juhtimist, perekonda, lapsepõlve, spordiga tegelemist, sõpruskonda, eraettevõtlusest loobumist ning suhteid kirikuga. Lisa: Jüri Ratas (27). Vt. samas lühiintervjuud linnapea abikaasa Karin Ratasega. Kommenteerib Jüri Ratase endine klassijuhataja Nõmme gümnaasiumist, võrkpallitreener Raimund Pundi

  16. The Birth Satisfaction Scale-Revised Indicator (BSS-RI).

    Science.gov (United States)

    Martin, Colin R; Hollins Martin, Caroline; Redshaw, Maggie

    2017-08-29

    The current study sought to develop a short birth satisfaction indicator utilising items from the Birth Satisfaction Scale-Revised (BSS-R) for use as a brief measure of birth satisfaction and as a possible key performance indicator for perinatal service delivery evaluation. Building on the recently developed BSS-R, the study aimed to develop a simplified version of the instrument to assess birth satisfaction easily that could work as a short evaluative measure of clinical service delivery for labour and birth that is consistent with policy documents, placing women at the centre of the birth experience. The six item Birth Satisfaction Scale-Revised Indicator (BSS-RI) was embedded within the 2014 National Maternity Survey for England. A random selection of mothers who had given birth in a two week period in England were surveyed three months after the birth. Using a two-stage design and split-half dataset, exploratory factor analysis, confirmatory factor analysis, internal consistency, convergent, divergent and known-groups discriminant validity evaluation were conducted in a secondary analysis of the survey data. Using this large population based survey of recent mothers the short revised measure was found to comprise two distinct domains of birth satisfaction, 'stress and emotional response to labour and birth' and 'quality of care'. The psychometric qualities of the tool were robust as were the indices of validity and reliability evaluated. The BSS-RI represents a short easily administered and scored measure of women's satisfaction with care and the experience of labour and birth. The instrument is potentially useful for researchers, service evaluation and policy makers.

  17. Genomic Locus Modulating IOP in the BXD RI Mouse Strains

    Directory of Open Access Journals (Sweden)

    Rebecca King

    2018-05-01

    Full Text Available Intraocular pressure (IOP is the primary risk factor for developing glaucoma, yet little is known about the contribution of genomic background to IOP regulation. The present study leverages an array of systems genetics tools to study genomic factors modulating normal IOP in the mouse. The BXD recombinant inbred (RI strain set was used to identify genomic loci modulating IOP. We measured the IOP in a total of 506 eyes from 38 different strains. Strain averages were subjected to conventional quantitative trait analysis by means of composite interval mapping. Candidate genes were defined, and immunohistochemistry and quantitative PCR (qPCR were used for validation. Of the 38 BXD strains examined the mean IOP ranged from a low of 13.2mmHg to a high of 17.1mmHg. The means for each strain were used to calculate a genome wide interval map. One significant quantitative trait locus (QTL was found on Chr.8 (96 to 103 Mb. Within this 7 Mb region only 4 annotated genes were found: Gm15679, Cdh8, Cdh11 and Gm8730. Only two genes (Cdh8 and Cdh11 were candidates for modulating IOP based on the presence of non-synonymous SNPs. Further examination using SIFT (Sorting Intolerant From Tolerant analysis revealed that the SNPs in Cdh8 (Cadherin 8 were predicted to not change protein function; while the SNPs in Cdh11 (Cadherin 11 would not be tolerated, affecting protein function. Furthermore, immunohistochemistry demonstrated that CDH11 is expressed in the trabecular meshwork of the mouse. We have examined the genomic regulation of IOP in the BXD RI strain set and found one significant QTL on Chr. 8. Within this QTL, there is one good candidate gene, Cdh11.

  18. Analysis of concept and application or Risk-Informed Performed-Based Regulation (RI-PBR)

    International Nuclear Information System (INIS)

    Kim, W. S.; Sung, K. Y.; Lee, C. J.; Kim, H. J.

    2002-01-01

    For improving regulation of nuclear power plants, the USNRC is adopting the Risk-Informed Performance-Based Regulation (RI-PBR) as an alternative, in parallel with implementing current deterministic regulation. This paper introduces a research plan for 'Institutionalization of RI-PBR' that is being conducted by KINS as a national project for evaluating feasibility for application of the alternative to Korean regulation system. Analysis of regulation characteristics, case study and experience on RI-PBR were presented as interim research results. In addition, the future plan of development of RI-PBR concept as understandable to the public and evaluation of level of techniques needed for implementation of RI-PBR was introduced

  19. Statistical dynamic imaging of RI-labeled tracer from list-mode PET data

    International Nuclear Information System (INIS)

    Tanimoto, Michiaki; Kuroda, Yoshihiro; Oshiro, Osamu; Watabe, Hiroshi; Kuroda, Tomohiro

    2009-01-01

    Positron emission tomography (PET) can be used in physiological analysis to illustrate physiological states by visualizing the accumulation of radioisotope (RI)-labeled tracer in specific organs or tissues. PET obtains spatio-temporal statistics in the form of list-mode data. However, conventional imaging techniques, which sum up list-mode data over a given time period, cannot depict detailed temporal dynamics of the RI-labeled tracer. In this study, a spatio-temporal analysis approach was employed to visualize the temporal flow dynamics of RI-labeled tracer from the obtained list-mode data. Experiments to assess the visualization of simulated RI-labeled tracer dynamics as well as RI-labeled tracer dynamics in a vascular phantom showed that the proposed method successfully depicted detailed temporal flow dynamics that could not be visualized using conventional methods. (author)

  20. Markers of Skeletal Muscle Mitochondrial Function and Lipid Accumulation Are Moderately Associated with the Homeostasis Model Assessment Index of Insulin Resistance in Obese Men

    Science.gov (United States)

    Samjoo, Imtiaz A.; Safdar, Adeel; Hamadeh, Mazen J.; Glover, Alexander W.; Mocellin, Nicholas J.; Santana, Jose; Little, Jonathan P.; Steinberg, Gregory R.; Raha, Sandeep; Tarnopolsky, Mark A.

    2013-01-01

    Lower skeletal muscle mitochondrial oxidative phosphorylation capacity (OXPHOS) and intramyocellular lipid (IMCL) accumulation have been implicated in the etiology of insulin resistance (IR) in obesity. The purpose of this study was to examine the impact of endurance exercise on biochemical and morphological measures of IMCL and mitochondrial content, and their relationship to IR in obese individuals. We examined mitochondrial content (subunit protein abundance and maximal activity of electron transport chain enzymes), IMCL/mitochondrial morphology in both subsarcolemmal (SS) and intermyofibrillar (IMF) regions by transmission electron microscopy, and intracellular lipid metabolites (diacylglycerol and ceramide) in vastus lateralis biopsies, as well as, the homeostasis model assessment index of IR (HOMA-IR) prior to and following twelve weeks of an endurance exercise regimen in healthy age- and physical activity-matched lean and obese men. Obese men did not show evidence of mitochondrial OXPHOS dysfunction, disproportionate IMCL content in sub-cellular regions, or diacylglycerol/ceramide accretion despite marked IR vs. lean controls. Endurance exercise increased OXPHOS and mitochondrial size and density, but not number of individual mitochondrial fragments, with moderate improvements in HOMA-IR. Exercise reduced SS IMCL content (size, number and density), increased IMF IMCL content, while increasing IMCL/mitochondrial juxtaposition in both regions. HOMA-IR was inversely associated with SS (r = −0.34; P = 0.051) and IMF mitochondrial density (r = −0.29; P = 0.096), IMF IMCL/mitochondrial juxtaposition (r = −0.30; P = 0.086), and COXII (r = −0.32; P = 0.095) and COXIV protein abundance (r = −0.35; P = 0.052); while positively associated with SS IMCL size (r = 0.28; P = 0.119) and SS IMCL density (r = 0.25; P = 0.152). Our findings suggest that once physical activity and cardiorespiratory fitness have

  1. Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men.

    Directory of Open Access Journals (Sweden)

    Imtiaz A Samjoo

    Full Text Available Lower skeletal muscle mitochondrial oxidative phosphorylation capacity (OXPHOS and intramyocellular lipid (IMCL accumulation have been implicated in the etiology of insulin resistance (IR in obesity. The purpose of this study was to examine the impact of endurance exercise on biochemical and morphological measures of IMCL and mitochondrial content, and their relationship to IR in obese individuals. We examined mitochondrial content (subunit protein abundance and maximal activity of electron transport chain enzymes, IMCL/mitochondrial morphology in both subsarcolemmal (SS and intermyofibrillar (IMF regions by transmission electron microscopy, and intracellular lipid metabolites (diacylglycerol and ceramide in vastus lateralis biopsies, as well as, the homeostasis model assessment index of IR (HOMA-IR prior to and following twelve weeks of an endurance exercise regimen in healthy age- and physical activity-matched lean and obese men. Obese men did not show evidence of mitochondrial OXPHOS dysfunction, disproportionate IMCL content in sub-cellular regions, or diacylglycerol/ceramide accretion despite marked IR vs. lean controls. Endurance exercise increased OXPHOS and mitochondrial size and density, but not number of individual mitochondrial fragments, with moderate improvements in HOMA-IR. Exercise reduced SS IMCL content (size, number and density, increased IMF IMCL content, while increasing IMCL/mitochondrial juxtaposition in both regions. HOMA-IR was inversely associated with SS (r = -0.34; P = 0.051 and IMF mitochondrial density (r = -0.29; P = 0.096, IMF IMCL/mitochondrial juxtaposition (r = -0.30; P = 0.086, and COXII (r = -0.32; P = 0.095 and COXIV protein abundance (r = -0.35; P = 0.052; while positively associated with SS IMCL size (r = 0.28; P = 0.119 and SS IMCL density (r = 0.25; P = 0.152. Our findings suggest that once physical activity and cardiorespiratory fitness have been

  2. Äriühingu juhatuse liikme teenistusalane suhe : [bakalaureusetöö] / Anneli Kiljako ; Tartu Ülikool, õigusteaduskond ; juhendaja: Inge-Maret Orgo

    Index Scriptorium Estoniae

    Kiljako, Anneli

    1999-01-01

    Äriühingu juhatuse liikme teenistusalase suhtega seonduvad probleemid, äriühingu juhatuse liikme ja ja äriühingu vahelise lepingu sõlmimine, poolte õigused, kohustused, vastutus; juhtimislepingu lõppemine

  3. Measurement of 3D refractive index distribution by optical diffraction tomography

    Science.gov (United States)

    Chi, Weining; Wang, Dayong; Wang, Yunxin; Zhao, Jie; Rong, Lu; Yuan, Yuanyuan

    2018-01-01

    Optical Diffraction Tomography (ODT), as a novel 3D imaging technique, can obtain a 3D refractive index (RI) distribution to reveal the important optical properties of transparent samples. According to the theory of ODT, an optical diffraction tomography setup is built based on the Mach-Zehnder interferometer. The propagation direction of object beam is controlled by a 2D translation stage, and 121 holograms based on different illumination angles are recorded by a Charge-coupled Device (CCD). In order to prove the validity and accuracy of the ODT, the 3D RI profile of microsphere with a known RI is firstly measured. An iterative constraint algorithm is employed to improve the imaging accuracy effectively. The 3D morphology and average RI of the microsphere are consistent with that of the actual situation, and the RI error is less than 0.0033. Then, an optical element fabricated by laser with a non-uniform RI is taken as the sample. Its 3D RI profile is obtained by the optical diffraction tomography system.

  4. FcepsilonRI-alpha siRNA inhibits the antigen-induced activation of mast cells.

    Science.gov (United States)

    Safaralizadeh, Reza; Soheili, Zahra-Soheila; Deezagi, Abdolkhaleg; Pourpak, Zahra; Samiei, Shahram; Moin, Mostafa

    2009-12-01

    FcepsilonRI, The high affinity receptor for IgE plays a critical role in triggering the allergic reactions. It is responsible for inducing mast cell degranulation and deliberation of allergy mediators when it is aggregated by allergen and IgE complexes. FcepsilonRI on the mast cells consists of three subunits; alpha chain directly binds IgE, beta chain and dimmer of gamma chains together mediate intracellular signaling. Cross-linking of IgE-bound FcepsilonRI on the surface of mast cells and basophils by the multivalent antigen induces release of chemical mediators. The present in vitro study was designed to investigate the effect of synthetic FcepsilonRI-alpha siRNA on the antigen-induced activation of MC/9 cells. MC/9 cells which are murine mast cells were transfected by FcepsilonRI-alpha siRNA and negative control siRNA. After 6 h, anti-DNP (Dinitrophenyl) IgE was used for the cells sensitization. Then the cells were challenged with Dinitrophenyl-Human Serum Albumin (DNP-HSA) for mast cell degranulation induction before collection of supernatants. The amount of mRNA and protein expression was measured by Real Time PCR and western blot analysis, respectively. Determination of the expression rate of FcepsilonRI-alpha on cell surface was achieved by flow cytometry. ELISA and spectrophotometry methods were used subsequently for measuring the effects of FcepsilonRI-alpha siRNA on antigen-induced histamine and beta-hexosaminidase release. FcepsilonRI-alpha siRNA treated cells showed significant decrease in FcepsilonRI-alpha mRNA and protein expression in comparison to control cells. FcepsilonRI-mediated mast cell release of beta-hexosaminidase and histamine were also inhibited. In this study it was shown that FcepsilonRI-alpha siRNA could suppress FcepsilonRI-alpha expression and inhibited degranulation and histamine release in antigen-stimulated MC/9 cells. In conclusion, knock-down of FcepsilonRI-alpha by siRNA could be a promising method for inhibition of the mast

  5. Study on electrical monitoring of fill-up improvement. Utilization of resistivity data for soil compaction management; Hiteiko mitsudo kanri ni kansuru kisoteki kenkyu. Moritsuchi seko kanri eno hiteiko yuko riyo

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, N; Hiramatsu, W [Dai Nippon Construction, Gifu (Japan); Sugano, T [Kyoto University, Kyoto (Japan). Faculty of Engineering

    1996-10-01

    At present, measurement of wet density and water content by radio isotope (RI method) is used for filling management. It is supposed for filling in road construction that putting-out thickness of banking material reaches nearly 1m in the future rapid construction, however, use of RI method is difficult because of inserting and installing of a radiation source rod, large measuring apparatus, and the legal regulation on radioactivity intensity. Application of resistivity measurement was thus considered. Since resistivity has the same parameter as compaction curve, and monotonously decreases with an increase in water content by volume, it is applicable as construction management index. The management reference of resistivity (Rm) is set by plotting of a compaction curve and corresponding resistivity curve, determination of the reference resistivity (Ro) corresponding to a maximum dry density and optimum water content ratio, and setting of the allowance to Ro according to soil or application. It was clarified that Rm is applicable as set for every filling material. 1 ref., 10 figs., 2 tabs.

  6. A scoping review of the uses of the care index in children

    NARCIS (Netherlands)

    Gupta, E; Innes, N; Schuller, A A; Vermaire, J H; Marshman, Z

    OBJECTIVE: To conduct a scoping review of literature to describe how the care index (CI) and restorative index (RI) are used in child populations and to determine whether they are fit for purpose. BASIC RESEARCH DESIGN: Scoping review conducted using the Arksey and O'Malley (2005) framework. METHOD:

  7. Äri- ja ettevõtluskeeldude piiriülene mõju / Maarja Torga, Juhan Sarv

    Index Scriptorium Estoniae

    Torga, Maarja, 1984-

    2017-01-01

    Eestis kohaldatud äri- ja ettevõtluskeeldude piiriülesest mõjust ning välisriigis kohaldatud äri- ja ettevõtluskeelu mõjust Eestis. Äri- ja ettevõtluskeeldude piiriülesest tsiviilõiguslikust ja karistusõiguslikust mõjust. Sisaldab asjakohast kohtupraktikat

  8. Highly sensitive refractive index fiber inline Mach-Zehnder interferometer fabricated by femtosecond laser micromachining and chemical etching

    Science.gov (United States)

    Sun, Xiao-Yan; Chu, Dong-Kai; Dong, Xin-Ran; Zhou, Chu; Li, Hai-Tao; Luo-Zhi; Hu, You-Wang; Zhou, Jian-Ying; Cong-Wang; Duan, Ji-An

    2016-03-01

    A High sensitive refractive index (RI) sensor based on Mach-Zehnder interferometer (MZI) in a conventional single-mode optical fiber is proposed, which is fabricated by femtosecond laser transversal-scanning inscription method and chemical etching. A rectangular cavity structure is formed in part of fiber core and cladding interface. The MZI sensor shows excellent refractive index sensitivity and linearity, which exhibits an extremely high RI sensitivity of -17197 nm/RIU (refractive index unit) with the linearity of 0.9996 within the refractive index range of 1.3371-1.3407. The experimental results are consistent with theoretical analysis.

  9. Remedial Investigation/Feasibility Study (RI/FS) process, elements and techniques guidance

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    This manual provides detailed guidance on Remedial Investigation/Feasibility Studies (RI/FSs) conducted pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) at Department of Energy (DOE) facilities. The purpose of the RI/FS, to assess the risk posed by a hazardous waste site and to determine the best way to reduce that risk, and its structure (site characterization, risk assessment, screening and detailed analysis of alternatives, etc.) is defined in the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) and further explained in the Environmental Protection Agency`s (EPA`s) Guidance for Conducting Remedial Investigations and Feasibility Studies Under CERCLA (Interim Final) 540/G-89/004, OSWER Directive 9355.3-01, October 1988. Though issued in 1988, the EPA guidance remains an excellent source of information on the conduct and structure of an RI/FS. This document makes use of supplemental RI/FS-related guidance that EPA has developed since its initial document was issued in 1988, incorporates practical lessons learned in more than 12 years of experience in CERCLA hazardous site remediation, and drawing on those lessons, introduces the Streamlined Approach For Environmental Restoration (SAFER), developed by DOE as a way to proceed quickly and efficiently through the RI/FS process at DOE facilities. Thus as its title implies, this guidance is intended to describe in detail the process and component elements of an RI/FS, as well as techniques to manage the RI/FS effectively.

  10. Yeast transformation mediated by Agrobacterium strains harboring an Ri plasmid: comparative study between GALLS of an Ri plasmid and virE of a Ti plasmid.

    Science.gov (United States)

    Kiyokawa, Kazuya; Yamamoto, Shinji; Sato, Yukari; Momota, Naoto; Tanaka, Katsuyuki; Moriguchi, Kazuki; Suzuki, Katsunori

    2012-07-01

    Agrobacterium strains containing a Ti plasmid can transfer T-DNA not only to plants but also to fungi, including the yeast Saccharomyces cerevisiae. However, no Agrobacterium strain harboring an Ri plasmid has been evaluated in fungal transformation. Some Ri plasmids have GALLS , instead of virE1 and virE2. GALLS protein can functionally substitute in plant transformation for a structurally different protein VirE2. In this study, we compared the yeast transformation ability among Agrobacterium donors: a strain containing a Ti plasmid, strains harboring either an agropine-type or a mikimopine-type Ri plasmid, and a strain having a modified Ri plasmid supplemented with a Ti plasmid type virE operon. Agrobacterium strains possessing GALLS transformed yeast cells far less efficiently than the strain containing virE operon. Production of GALLS in recipient yeast cells improved the yeast transformation mediated by an Agrobacterium strain lacking neither GALLS nor virE operon. A reporter assay to detect mobilization of the proteins fused with Cre recombinase revealed that VirE2 protein is much more abundant in yeast cells than GALLS. Based on these results, we concluded that the low yeast transformability mediated by Agrobacterium strains having the Ri plasmid is because of low amount of mobilized GALLS in yeast cells. © 2012 The Authors Journal compilation © 2012 by the Molecular Biology Society of Japan/Blackwell Publishing Ltd.

  11. The mosaic genome structure of the Wolbachia wRi strain infecting Drosophila simulans

    DEFF Research Database (Denmark)

    Klasson, Lisa; Westberg, Joakim; Sapountzis, Panagiotis

    2009-01-01

    genome of W. pipientis strain wRi that induces very strong cytoplasmic incompatibility in its natural host Drosophila simulans. A comparison with the previously sequenced genome of W. pipientis strain wMel from Drosophila melanogaster identified 35 breakpoints associated with mobile elements and repeated...... sequences that are stable in Drosophila lines transinfected with wRi. Additionally, 450 genes with orthologs in wRi and wMel were sequenced from the W. pipientis strain wUni, responsible for the induction of parthenogenesis in the parasitoid wasp Muscidifurax uniraptor. The comparison of these A...

  12. Application of RI power sources to cardiac pacemakers and aftercare in its implantation

    International Nuclear Information System (INIS)

    Hori, Motokazu

    1974-01-01

    RI power sources have long life when they are implanted into human bodies together with cardiac pacemakers, as compared with e.g. mercury batteries. Therefore, the frequency of their replacement can be by far less. However, there are the problems of radiation protection, high cost, availability, etc. The following matters are described: The cardiac pacemaker and its power supply, implantation into human body, problems with patients and conventional power sources; the current state of RI power sources for cardiac pacemakers, including plutonium-238 RTG and 147 Pm and 3 H batteries; and problems with the RI power sources. (Mori, K.)

  13. Laser spectroscopy of exotic RI atoms in superfluid helium-OROCHI experiment

    International Nuclear Information System (INIS)

    Furukawa, T.; Matsuo, Y.; Hatakeyama, A.; Fujikake, K.; Matsuura, Y.; Kobayashi, T.; Shimoda, T.

    2010-01-01

    We have been developing a new laser spectroscopic technique 'OROCHI,' which is based on the combination of superfluid helium as a stopper of radioactive isotope (RI) beam and in-situ laser spectroscopy of RI atoms, for determining spins and moments of exotic RIs. By using this unique technique, it is feasible to measure nuclear spins and electromagnetic moments of extremely low yield RI (estimated as less than 1 pps). Recently, we have demonstrated that nuclear spins and moments are obtained from Zeeman and hyperfine splittings of stable Rb isotopes measured using this OROCHI technique. Details of this laser spectroscopy method in He II 'OROCHI' and the summary of our development are presented.

  14. An illustrative case of Léri-Weill dyschondrosteosis

    Directory of Open Access Journals (Sweden)

    Renata de Lima

    2008-01-01

    Full Text Available We report on a girl presenting Léri-Weill dyschondrosteosis (LWD due to deletion of the SHOX gene. Her family included individuals with short stature alone or with both short stature and mesomelia or Madelung's deformity. The deletion was demonstrated through detection of hemizygosity for microsatellite markers SHOX-CA repeat, DXYS10092, DXYS10093 and DXYS10091 localized around the SHOX gene, with retention of paternal alleles in the proband and three of her sisters who had short stature as the only clinical feature. Hemizygosity for these loci was also observed in their mother, who had short stature too. The deletion in the proband was however larger, including locus DXY10083. The proband's only sister with normal height did not carry the deletion. Family history suggests transmission of the deletion from the proband's maternal great-grandfather to her grandfather via the Y chromosome, and from the grandfather to the proband's mother via the X chromosome after crossing-over in the pseudoautosomal region proximal to the SHOX gene.

  15. A generic risk assessment from unrestricted releases for RI waste

    International Nuclear Information System (INIS)

    Won-Jae Park; Sang-hoon Park

    1993-01-01

    It has long been recognized in the nuclear industries and the regulatory body that exemption from the regulatory control for a given practice or source of radioactive materials, which is very low radiation exposure situation where the level of risk to any of the public would be considered as trivial, may be beneficial and practical. Therefore, it is necessary to establish the exempt levels of radioactive wastes for unconditional disposal, incineration, recycle and reuse of slightly contaminated materials. In Korea, from its announcement of the Enforcement Regulation of Atomic Energy Act, the Article 97 (Exemption from Permanent Disposal) for very low-level waste disposal in January 1990, the KINS (Korea Institute of Nuclear Safety) have made their efforts to establish a de minimis level (a level of radioactivity in waste that is sufficiently low that the waste can be disposed of as ordinary, non-radioactive trash) for short-lived radioisotopes commonly used in medical, research institutes and industrial applications and to study the possibility for unrestricted deregulation of those radioisotopes. As one of preliminary works to predict environmental radiological impacts from uncontrolled and unrestricted release of RI waste, an average effective dose to any ordinary individual and a collective dose for total population in Korea was estimated, based on conservative assumptions and Korean specific environment data, by an equilibrium biosphere models with a generic probabilistic risk approach

  16. RIKEN RI Beam Factory and recent research activities

    International Nuclear Information System (INIS)

    Ueno, H.

    2014-01-01

    RIKEN has started the operation of the new facility for the Radioactive-Isotope Beam Factory (RIBF) project since 2006. In this project, intense primary beams are delivered at the energy E/A = 345 MeV over the whole range of the atomic number under the cyclotron-cascade acceleration scheme. The current, stability and sustainability in beam delivery have been increased significantly by recent improvement of the accelerator system. A high-current primary beam is then used to produce radioactive-isotope beams at the world's highest current utilizing the superconducting in-flight RI separator BigRIPS. Following the BigRIPS separator, several large-scale experimental key devices have been / will be installed, in order to fully capitalize the RIBF project. Owing to these progresses, nuclear structure information on far-unstable nuclei, which cannot be obtained by conventional technology, are now capable of being measured. Furthermore, in addition to such BigRIPS-related devices, other original experimental devices have been also newly installed at the lower energy experimental sites. Unique research opportunities are now available at the RIBF facility. (author)

  17. Measurement of the refractive index of soft contact lenses during wear.

    Science.gov (United States)

    Varikooty, Jalaiah; Keir, Nancy; Woods, Craig A; Fonn, Desmond

    2010-01-01

    To determine whether the refractive index (RI) of a soft contact lens can be evaluated using refractometry while the lens remains on the eye and to compare this with more traditional ex vivo RI measurements. A slitlamp apparatus was modified to incorporate a customized Atago hand refractometer. With a double-masked study design, nine adapted symptomatic soft contact lens wearers wore a contact lens in each eye (lotrafilcon B and etafilcon A) in a randomized order. In vivo RI was determined from the relative Brix scale measurements immediately after lens insertion and after 1 and 10 hr of lens wear. Ex vivo refractometry was performed after 10 hr of lens wear for comparison. Means +/- standard errors of the means are reported. In vivo RI values at baseline were 1.422 +/- 0.0004 (lotrafilcon B) and 1.405 +/- 0.0021 (etafilcon A); after 1 hr of lens wear, values were 1.423 +/- 0.0006 and 1.408 +/- 0.0007, respectively; and after 10 hr of lens wear, values were 1.424 +/- 0.0004 and 1.411 +/- 0.0010, respectively. Ex vivo RI values at the end of the 10 hr wearing period were 1.424 +/- 0.0003 (lotrafilcon B) and 1.412 +/- 0.0017 (etafilcon A). The change in in vivo RI across the day was statistically significant for the etafilcon A lens (repeated-measures analysis of variance, P0.05). This novel adaptation of refractometry was able to measure the RI of soft contact lenses during wear (without lens removal). End of day RI measurements using in vivo and ex vivo refractometry were comparable with each other. Future work is required to determine whether this in vivo method can improve our understanding of the relationships between soft contact lens RI, hydration, on-eye lens performance, and symptomology.

  18. Maamesilasena maailmas ehk lihtsalt Jüri Talveti meetodist / On Jüri Talvet’s Comparative Method

    Directory of Open Access Journals (Sweden)

    Arne Merilai

    2016-12-01

    Full Text Available Teesid: Artikkel defineerib maailmakirjanduse professor Jüri Talveti komparativistlikku meetodit nii maamesilase metafoori kui ka tema poolt tutvustatud mõistete edaphos (’pind’ ja episteme (’teadmine’ kaudu. Võrdleva kirjandusteadlase ülesanne on kahesuunaline: tutvustada eesti kirjandust maailmas ja vahendada mujal loodut meie kultuurile. Kuigi õpetlaste teoreetiline metasüsteem ja mõistevõrk – episteme – võib areneda väga keeruliseks, peab see alati juurduma edaphos’es kui toitvas pinnases, mille loovad sõnakunstiteosed ja rahvuslikud kirjanduslood. Avardades võrdlevat edaphos’t, aktiveerime ja rikastame ka maailma episteme’t.   The article aims at defining the comparative method of Jüri Talvet, professor of comparative literature. This can be carried out by an application of Talvet’s own metaphor for himself – a bumble bee, or via two concepts elaborated by him – edaphos (base and episteme (knowledge. The bumble bee, by nature more reclusive and peaceful but somehow more attractive looks than a regular bee flies out from its modest sod nest across blooming meadows, disseminating homely pollen among the leaves of grass of the wide world. Then it faithfully returns with nourishing nectar that feeds its family. As chairman of the Estonian Comparative Literature Association, and founder and editor-in-chief of the comparative literature journal Interlitteraria, Talvet has written: “Its purpose is to channel new literary-philosophical ideas from the international area to Estonia and, at the same time, to spread knowledge about Estonian literary and philosophical studies outside Estonia, as well as to let the wider world have some idea of Estonian literature itself which, because of the language barrier, has belonged traditionally to the majority of “silent” literatures of the world, unjustly ignored by the area of the dominant Western languages.” Yet, no matter how complex our theoretical meta

  19. A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum.

    Directory of Open Access Journals (Sweden)

    Eleonora Dehlink

    Full Text Available Soluble IgE receptors are potential in vivo modulators of IgE-mediated immune responses and are thus important for our basic understanding of allergic responses. We here characterize a novel soluble version of the IgE-binding alpha-chain of Fc-epsilon-RI (sFcεRI, the high affinity receptor for IgE. sFcεRI immunoprecipitates as a protein of ∼40 kDa and contains an intact IgE-binding site. In human serum, sFcεRI is found as a soluble free IgE receptor as well as a complex with IgE. Using a newly established ELISA, we show that serum sFcεRI levels correlate with serum IgE in patients with elevated IgE. We also show that serum of individuals with normal IgE levels can be found to contain high levels of sFcεRI. After IgE-antigen-mediated crosslinking of surface FcεRI, we detect sFcεRI in the exosome-depleted, soluble fraction of cell culture supernatants. We further show that sFcεRI can block binding of IgE to FcεRI expressed at the cell surface. In summary, we here describe the alpha-chain of FcεRI as a circulating soluble IgE receptor isoform in human serum.

  20. Erkki-Sven Tüüri vioolakontsert "Illuminatio" / Igor Grašnek

    Index Scriptorium Estoniae

    Grašnek, Igor, 1958-

    2009-01-01

    Erkki-Sven Tüüri vioolakontserdist "Illuminatio", mis tuli Eestis esiettekandele 20. veebruaril Estonia kontserdisaalis ja mida esitasid vioolamängija Lars Anders Tomter ning ERSO Olari Eltsi dirigeerimisel

  1. Tüüri autoriplaat on MIDEM-i auhinna nominent

    Index Scriptorium Estoniae

    2008-01-01

    Muusikamessi MIDEM klassikalise muusika plaatide auhinnaõhtul on üheks preemia nominendiks Luciano Berio ja Krzysztof Penderecki kõrval Erkki-Sven Tüüri autoriplaat "Magma", messist 27.-31. jaan. Cannes'is Prantsusmaal

  2. Abilinnapea Ratas pidas uputust paratamatuseks / Jüri Ratas ; interv. Piret Reiljan

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2004-01-01

    Tallinna abilinnapea Jüri Ratas kommenteerib olukorda linnas, kus kahe päevaga sadas maha rohkem kui juulikuu sademete norm ette näeb. Vt. samas Meelis Eldermann. Miks veevärk vihmaga toime ei tulnud?

  3. Aiandusäri jahtumismärke ei ilmuta / Aive Herja

    Index Scriptorium Estoniae

    Herja, Aive

    2008-01-01

    Haljastus- ja aiandusäri praegu veel jahtumismärke ei ilmuta. Arvamust avaldavad aiandusettevõtete juhid. Lk. 28 intervjuu maastikuarhitektuurifirma Artes Terrae OÜ juhatuse liikme Sulev Nurmega "Sulev Nurme: maastikuarhitektuuri turg on kasvutrendis"

  4. Sotsiaalteaduskond 1993-2007 / Kristel Marmor ; meenutavad Aleksander Pulver, Jüri Kruusvall ja Arno Baltin

    Index Scriptorium Estoniae

    Marmor, Kristel

    2008-01-01

    11. jaanuaril 2008. aastal tähistas sotsiaalteaduskond oma 15. tegevusaastat ja samas ka matust. Meenutused psühholoogiaprofessor Aleksander Pulverilt, sotsioloogia vanemteadurilt Jüri Kruusvallilt ning matusekõne Arno Baltinilt

  5. Rae vald ja Jüri elanikud sõdivad tehnopargi ohtliku tehase vastu / Mari Kodres

    Index Scriptorium Estoniae

    Kodres, Mari

    2008-01-01

    Ettevõte Stainless Surface Technology OÜ soovib rajada Jüri tehnoparki metallide hapetega töötlemise tehase. Rae valla ehitusameti juhataja Enno Harmipaiga hinnangul on probleem tehase ja elumajade ühine kanalisatsioon

  6. Piiratud vastutusega äriühingu juhatuse liikme lojaalsuskohustus / Tuuve Tiivel

    Index Scriptorium Estoniae

    Tiivel, Tuuve, 1977-

    2001-01-01

    Huvide konfliktist aktsiaseltsi ja selle juhatuse liikme vahelise tehingu puhul, sellise tehingu kehtivusest, juhatuse liikme tasust, laenu- ja konkurentsikeelust ning konfidentsiaalsuskohustusest Eesti ja Ameerika Ühendriikide äriõiguses

  7. riöö võit Saue Tammedele / Arvo Saal

    Index Scriptorium Estoniae

    Saal, Arvo

    2008-01-01

    Padisel toimunud 49. Jüriöö jooksul võitsid peaauhinna, Kalevipoja kuju kuuendat korda Saue Tammede spordiklubi esimese võistkonna orienteerujad Jürgen Einpalu, Kirti Rebane, Peeter Pihl, Viivi-Anne Soots ja Erkki Aadli

  8. Study on the Contribution of Nuclear and RI Technology to the National Economy

    International Nuclear Information System (INIS)

    Lee, Man Ki; Moon, K. H.; Kim, S. S.

    2004-12-01

    This study evaluated the economic value addition of nuclear power generation technology and radio-isotope(RI) technology quantitatively by using modified Input-Output table. For the nuclear power generation technology, the economic effect of both power plant construction and operation was evaluated. On the other hand, the economic effect of the RI utilization on the national economy was evaluated for RI technology. Firstly, the total economic value addition from nuclear power generation(both construction and operation) was estimated as 1.4% of Gross Domestic Product(GDP) in 2000. Among them, 1.2% was from nuclear power plant operation and the rest was from construction. On the other hand, the economic value addition from RI technology has continuously increased. Its share of GDP increased from 0.30% in 1980 to 0.58 in 2000

  9. Muusikaäri otsib uusi müügiideid / Kuldar Kullasepp

    Index Scriptorium Estoniae

    Kullasepp, Kuldar, 1980-

    2009-01-01

    IT- valdkonna muusiakäri uutest võimalustest. USA firmast Rdio, Niklas Zennströmi ja Janus Friisi pakutavast tensuest, millega pakutakse muusikat nii arvuti kui ka mobiiltelefoniaskutajatele pakkuda. Digitaalsetest plaadipoodidest Eestis

  10. Reiu Tüüri maratonloeng kunstiturust / Reiu Tüür

    Index Scriptorium Estoniae

    Tüür, Reiu

    2001-01-01

    27. VI toimus Pärnus Kunstplatze Unobomberi galeriis Reiu Tüüri näitus-loeng kaasaegse kunsti galeriidest Londonis ja Eestis. Näitus on osa R. Tüüri sel sügisel Londoni linnaülikooli juures kaitstavast kunsti mänedzhmendi alasest magistritööst "Eesti kaasaegse kunsti turg". Juhendaja Jani Robertson Hollandist.

  11. A Study on the Representative Sampling Survey for Radionuclide Analysis of RI Waste

    Energy Technology Data Exchange (ETDEWEB)

    Jee, K. Y. [KAERI, Daejeon (Korea, Republic of); Kim, Juyoul; Jung, Gunhyo [FNC Tech. Co., Daejeon (Korea, Republic of)

    2007-07-15

    We developed a quantitative method for attaining a representative sample during sampling survey of RI waste. Considering a source, process, and type of RI waste, the method computes the number of sample, confidence interval, variance, and coefficient of variance. We also systematize the method of sampling survey logically and quantitatively. The result of this study can be applied to sampling survey of low- and intermediate-level waste generated from nuclear power plant during the transfer process to disposal facility.

  12. Effect of non-surgical periodontal therapy on insulin resistance in patients with type II diabetes mellitus and chronic periodontitis, as assessed by C-peptide and the Homeostasis Assessment Index.

    Science.gov (United States)

    Mammen, Jerry; Vadakkekuttical, Rosamma Joseph; George, Joseraj Manaloor; Kaziyarakath, Jaishid Ahadal; Radhakrishnan, Chandni

    2017-08-01

    A bidirectional relationship exists between diabetes and periodontitis. In the present clinical trial, we evaluated the effects of non-surgical periodontal therapy (NSPT) on insulin resistance in patients with type II diabetes mellitus (DM) and chronic periodontitis. Forty chronic periodontitis patients with type II DM were selected and equally allocated to case and control groups. All patients were assessed for periodontal parameters and systemic parameters. The case group received NSPT, and both groups were re-evaluated after 3 months. All periodontal parameters were found to be significantly improved in the case group compared to the control group 3 months after NSPT. The mean differences in systemic parameters, such as fasting serum C-peptide, Homeostasis Assessment (HOMA) Index-insulin resistance, and HOMA-insulin sensitivity, from baseline to 3 months for the case group were 0.544 ± 0.73, 0.54 ± 0.63, and -25.44 ± 36.81, respectively; for the control group, they were significant at -1.66 ± 1.89, -1.48 ± 1.86, and 31.42 ± 38.82 respectively (P periodontal inflammation could affect glycemic control and insulin resistance. Effective periodontal therapy reduced insulin resistance and improved periodontal health status and insulin sensitivity in patients with type II DM and chronic periodontitis. © 2016 John Wiley & Sons Australia, Ltd.

  13. Automated Bone Scan Index as a quantitative imaging biomarker in metastatic castration-resistant prostate cancer patients being treated with enzalutamide

    DEFF Research Database (Denmark)

    Anand, Aseem; Morris, Michael J.; Larson, Steven M

    2016-01-01

    alone (C-index 0.73), p = 0.041. Conclusions: The upgraded and analytically validated automated BSI was found to be a strong predictor of OS in mCRPC patients. Additionally, the change in automated BSI demonstrated an additive clinical value to the change in PSA in mCRPC patients being treated...

  14. Competency remodelling and application plans for development of job competency in RI-biomics

    International Nuclear Information System (INIS)

    Shin, Woo Ho; Park, Tai Jin

    2017-01-01

    RI-Biomics technology is advanced convergence technologies that can be measured in real time and track in vivo behavior and metabolism of substances using characteristics of the radioactive isotope. Its application fields are increasing such as drug development, agriculture, development of new materials and their utilization, etc. In addition, according to domestic and international developments and changes in the RI-Biomics environment, RI-Biomics professionals are needed to train continuously. To develop systematic human resources basement and competency-based curriculum, we perform competency modeling of pedagogical perspective to targeted at high-performance on RI-Biomics. Furthermore, we redefine the competency model and verified by industry experts with focus group interviews. In the result, two general competencies and three professional competencies were extracted by interview. Each competencies are organized six sub-competencies and nine sub-competencies. In the final steps, the same procedures were repeated to obtain the consensus of experts on derived competencies and behavioral objectives. The results of the study are applicable to enhance human resource management and to develop the curriculum for RI-Biomics expert training. It is expected to be used as reference material of long term-planning for RI-Biomics professional

  15. Competency remodelling and application plans for development of job competency in RI-biomics

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Woo Ho; Park, Tai Jin [Korean Association for Radiation Application, Seoul (Korea, Republic of)

    2017-03-15

    RI-Biomics technology is advanced convergence technologies that can be measured in real time and track in vivo behavior and metabolism of substances using characteristics of the radioactive isotope. Its application fields are increasing such as drug development, agriculture, development of new materials and their utilization, etc. In addition, according to domestic and international developments and changes in the RI-Biomics environment, RI-Biomics professionals are needed to train continuously. To develop systematic human resources basement and competency-based curriculum, we perform competency modeling of pedagogical perspective to targeted at high-performance on RI-Biomics. Furthermore, we redefine the competency model and verified by industry experts with focus group interviews. In the result, two general competencies and three professional competencies were extracted by interview. Each competencies are organized six sub-competencies and nine sub-competencies. In the final steps, the same procedures were repeated to obtain the consensus of experts on derived competencies and behavioral objectives. The results of the study are applicable to enhance human resource management and to develop the curriculum for RI-Biomics expert training. It is expected to be used as reference material of long term-planning for RI-Biomics professional.

  16. RiTSE/KCGE: Application of artificial intelligence to improve plant availability

    International Nuclear Information System (INIS)

    Frank, M.V.; Epstein, S.A.

    1986-01-01

    Maintenance and other personnel related errors are a major cause of reactor trips in some U.S. plants. Software called RiTSE and KCGE, that can operate on a mini-computer work station, has been developed to dramatically reduce trips caused by clearance coordination problems. Such problems arise because of the enormous number of components that interrelate in ways that cannot always be anticipated during plant operation. Concurrent maintenance, test, surveillance and other operations activities contribute to the unanticipated interactions. RiTSE allows the appropriate plant personnel (i.e., those responsible for authorizing work during start-up and operation) to predict if their next authorizations would cause a reactor trip. With KCGE, RiTSE can warn these personnel of a condition of significantly reduced margin to trip. RiTSE also aids post-trip cause analysis by pointing out those components that could have contributed to the trip. It is believable that use of RiTSE is a quicker and more reliable way to authorize work during operation than reliance on memory and drawings. The software provides maximum benefit when used in conjunction with a configuration management program that assures accurate plant presentation and accurate updating of component status during operation. Application of RiTSE and KCGE to a client's PWR demonstrated part of their potential benefits. (Nogami, K.)

  17. 77 FR 5581 - Submission for Review: Financial Resources Questionnaire (RI 34-1, RI 34-17) and Notice of Amount...

    Science.gov (United States)

    2012-02-03

    ... OFFICE OF PERSONNEL MANAGEMENT Submission for Review: Financial Resources Questionnaire (RI 34- 1... opportunity to comment on a revised information collection request (ICR) 3206-0167, Financial Resources... collection techniques or other forms of information technology, e.g., permitting electronic submissions of...

  18. The serum concentration of tumor necrosis factor alpha is not an index of growth-hormone- or obesity-induced insulin resistance.

    Science.gov (United States)

    Pincelli, A I; Brunani, A; Scacchi, M; Dubini, A; Borsotti, R; Tibaldi, A; Pasqualinotto, L; Maestri, E; Cavagnini, F

    2001-01-01

    The tumor necrosis factor alpha (TNF-alpha) might play a central role in insulin resistance, a frequent correlate of obesity likely contributing to some obesity-associated complications. Adult growth hormone (GH) deficiency syndrome (GHDA) shares with obesity excessive fat mass, hyperlipidemia, increased cardiovascular risk, and insulin resistance. On the other hand, GH has been shown to induce transient deterioration of glucose metabolism and insulin resistance when administered in normal humans and in GHDA patients. No information is presently available on the relationship between serum TNF-alpha levels and insulin sensitivity in GHDA. We compared the serum TNF-alpha levels found in 10 GHDA patients before and after a 6-month recombinant human GH therapy (Genotropin), in an insulin resistance prone population of 16 obese (OB) patients and in 38 normal-weight healthy blood donors (controls). The insulin sensitivity was assessed by a euglycemic-hyperinsulinemic glucose clamp in all the GHDA patients and in 10 OB and in 6 control subjects. The serum TNF-alpha levels were not significantly different in OB patients (42.2 +/- 12.81 pg/ml), in GHDA patients at baseline (71.3 +/- 23.97 pg/ml), and in controls (55.3 +/- 14.28 pg/ml). A slight decrease of TNF-alpha values was noted in GHDA patients after 6 months of recombinant human GH treatment (44.5 +/- 20.19 pg/ml; NS vs. baseline). The insulin sensitivity (M) was significantly reduced in OB patients (2.4 +/- 0.30 mg/kg/min) as compared with control subjects (7.5 +/- 0.39 mg/kg/min) and in GHDA patients both at baseline (6.6 +/- 0.6 mg/kg/min) and after recombinant human GH therapy (5.6 +/- 0.7 mg/kg/min). The insulin sensitivity in the GHDA patients, similar to that of controls at baseline, worsened after recombinant human GH treatment (p < 0.05 vs. baseline; p = 0.05 vs. controls). Linear regression analysis showed no correlation between TNF-alpha and M values (see text) in all patient groups. These data indicate

  19. Indicadores do perfil lipídico plasmático relacionados à resistência à insulina Plasmatic lipid profile indicators related to insulin resistance

    Directory of Open Access Journals (Sweden)

    Ana Carolina Junqueira Vasques

    2009-01-01

    Full Text Available OBJETIVOS: Investigar a habilidade de indicadores bioquímicos do perfil lipídico plasmático em identificar resistência à insulina (RI, avaliada pelo índice HOMA-IR (Homeostasis Model Assessment - Insulin Resistance. MÉTODOS: Foram avaliados 138 homens saudáveis (20-59 anos. Analisaram-se os seguintes indicadores bioquímicos do perfil lipídico: triglicérides (TG, colesterol total (CT, HDL-C, LDL-C, e as relações CT/HDL-C e TG/HDL-C. Considerou-se o percentil 75 como ponto de corte para o índice HOMA-IR. A análise estatística constou do cálculo do coeficiente de correlação de Spearman e da construção de curvas ROC, com o cálculo das áreas abaixo da curva (AUC. RESULTADOS: A relação TG/HDL-C (r = 0.334 e AUC = 0.724 ± 0.046 p 0,05. CONCLUSÃO: A relação TG/HDL-C apresentou melhor habilidade em identificar RI, representando um instrumento alternativo e de fácil acesso para a avaliação da RI na prática clínica, proporcionando intervenções de caráter preventivo de doenças na população do sexo masculino.PURPOSE: To investigate the effectiveness of biochemical indicators from the plasmatic lipid profile to identify the insulin resistance (IR, assessed by the HOMA-IR index (Homeostasis Model Assessment -Insulin Resistance. METHODS: 138 healthy men (20-59 years were evaluated. The lipid profile biochemical indicators analyzed were the following: triglycerides (TG, total cholesterol (TC, HDL-C, LDL-C, and TC/HDL-C and TG/HDL-C ratios. The percentile 75 was considered as the cut-off point for IR. Statistical analysis consisted of Spearman correlation coefficient, ROC curves and calculation of the areas under the curve (AUC. RESULT: The TG/HDL-C ratio showed the strongest correlation and the greatest AUC (r = 0.334 and AUC = 0.724 ± 0.046, p 0.05. CONCLUSION: The TG/HDL-C ratio showed the greatest ability to identify IR, proved to be an alternative and easy access instrument to assess IR in clinical practice, therefore

  20. Indicadores antropométricos de resistência à insulina Indicadores antropométricos de resistencia a la insulina Anthropometric indicators of insulin resistance

    Directory of Open Access Journals (Sweden)

    Ana Carolina Vasques

    2010-07-01

    corporal y de la relación cintura/cadera fueron más inconsistentes. Se sugiere la realización de estudios evaluando el desempeño de esos indicadores para predecir RI en la población brasileña, pues resultados de estudios hechos con otras poblaciones muchas veces no son aplicables a la nuestra, debido a las diferencias étnicas resultantes de la gran mezcla de razas en el País.Some studies have analyzed the efficacy of anthropometric indicators in predicting insulin resistance (IR, for they are more economic and accessible. In this study, the objective was to discuss the measures and anthropometric indices that have been associated with IR. A bibliographic review was done, based on Scielo, Science Direct and Pubmed. Among these studies, waist and sagittal abdominal diameter presented better predictive capacity for IR, with more consistent results. The waist-to-thigh, waist-to-size, neck-to-thigh ratios, the conicity and the sagittal index have showed positive results; nevertheless, more studies are necessary to consolidate them as predictors to IR. The obtained results, with the use of body mass index and of the waist-to-hip ratio, were inconsistent. In the Brazilian population, the realization of studies evaluating the performance of these indicators in predicting IR is suggested, since the results of the studies conducted in other populations are not always applicable to ours, due to ethnical differences resulting from the great miscegenation in the country.

  1. Walkability Index

    Science.gov (United States)

    The Walkability Index dataset characterizes every Census 2010 block group in the U.S. based on its relative walkability. Walkability depends upon characteristics of the built environment that influence the likelihood of walking being used as a mode of travel. The Walkability Index is based on the EPA's previous data product, the Smart Location Database (SLD). Block group data from the SLD was the only input into the Walkability Index, and consisted of four variables from the SLD weighted in a formula to create the new Walkability Index. This dataset shares the SLD's block group boundary definitions from Census 2010. The methodology describing the process of creating the Walkability Index can be found in the documents located at ftp://newftp.epa.gov/EPADataCommons/OP/WalkabilityIndex.zip. You can also learn more about the Smart Location Database at https://edg.epa.gov/data/Public/OP/Smart_Location_DB_v02b.zip.

  2. Age and body mass index-dependent relationship between correction of iron deficiency anemia and insulin resistance in non-diabetic premenopausal women

    International Nuclear Information System (INIS)

    Ozdemir, A.; Sevnic, C.; Selamaet, U.; Kamaci, B.; Atalay, S.

    2007-01-01

    No prospective studies have evaluated the effects of correction of iron deficiency anemia on insulin resistance in non-diabetic premenopausal women with iron deficiency anemia. All patients were treated with oral iron preparations. Insulin resistance was calculated with the Homeostasis Model Assessment formula. All patients were dichotomized by the median for age and BMI to assess how the relationship between iron deficiency anemia and insulin resistance was affected by the age and BMI. Although the fasting glucose levels did not change meaningfully, statistically significant decreases were found in fasting insulin levels following anemia treatment both in the younger age ( = 40 years) and the high BMI (>-27Kg/m) subgroups. Post-treatment fasting insulin levels were positively correlated both with BMI (r=0.386, P=0.004) and post-treatment hemoglobin levels. (r=0.285, P=0.036). Regression analysis revealed that the factors affecting post-treatment insulin levels were BMI (P=0.001) and post-treatment hemoglobin levels (p=0.030). Our results show that following he correction of iron deficiency anemia, insulin levels and HOMA scores decrease in younger and lean non-diabetic premenopausal women. (author)

  3. Absence of kdr resistance alleles in the Union of the Comoros, East Africa [v1; ref status: indexed, http://f1000r.es/5fw

    Directory of Open Access Journals (Sweden)

    Yoosook Lee

    2015-06-01

    Full Text Available Knockdown resistance (kdr and CYP9K1 genotypes were detected by a MOLDI-TOF based SNP genotyping assay (Sequenom iPLEX in samples of Anopheles gambiae collected at 13 sites throughout the Union of the Comoros and Dar es Salaam, Tanzania during February and March 2011. All A. gambiae specimens collected in the Comoros were homozygous for the susceptible kdr alleles (+/+ while 96% of A. gambiae from Dar es Salaam were homozygous for the East African kdr resistant genotype (E/E. In contrast, all specimens from Dar es Salaam and the Comoros were homozygous for the cyp3 allele (c3/c3 at the CYP9K1 locus; the locus has been implicated in metabolic resistance against pyrethroid insecticides in West Africa. All specimens had typical A. gambiae genotypes for SNPs within the divergence Islands on all three chromosomes. Although further spatial and temporal studies are needed, the distribution of kdr genotypes between the Comoros and Tanzania further supports isolation of the Comoros populations from A. gambiae populations on mainland Africa.

  4. Combining first-principles and data modeling for the accurate prediction of the refractive index of organic polymers

    Science.gov (United States)

    Afzal, Mohammad Atif Faiz; Cheng, Chong; Hachmann, Johannes

    2018-06-01

    Organic materials with a high index of refraction (RI) are attracting considerable interest due to their potential application in optic and optoelectronic devices. However, most of these applications require an RI value of 1.7 or larger, while typical carbon-based polymers only exhibit values in the range of 1.3-1.5. This paper introduces an efficient computational protocol for the accurate prediction of RI values in polymers to facilitate in silico studies that can guide the discovery and design of next-generation high-RI materials. Our protocol is based on the Lorentz-Lorenz equation and is parametrized by the polarizability and number density values of a given candidate compound. In the proposed scheme, we compute the former using first-principles electronic structure theory and the latter using an approximation based on van der Waals volumes. The critical parameter in the number density approximation is the packing fraction of the bulk polymer, for which we have devised a machine learning model. We demonstrate the performance of the proposed RI protocol by testing its predictions against the experimentally known RI values of 112 optical polymers. Our approach to combine first-principles and data modeling emerges as both a successful and a highly economical path to determining the RI values for a wide range of organic polymers.

  5. An International, Multi-Specialty Validation Study of the IgG4-Related Disease Responder Index.

    Science.gov (United States)

    Wallace, Zachary S; Khosroshahi, Arezou; Carruthers, Mollie D; Perugino, Cory A; Choi, Hyon; Campochiaro, Corrado; Culver, Emma L; Cortazar, Frank; Della-Torre, Emanuel; Ebbo, Mikael; Fernandes, Ana; Frulloni, Luca; Hart, Philip; Karadag, Omer; Kawa, Shigeyuki; Kawano, Mitsuhiro; Kim, Myung-Hwan; Lanzillotta, Marco; Matsui, Shoko; Okazaki, Kazuichi; Ryu, Jay H; Saeki, Takako; Schleinitz, Nicolas; Tanasa, Paula; Umehara, Hisanori; Webster, George; Zhang, Wen; Stone, John H

    2018-02-18

    IgG4-related disease (IgG4-RD) can cause fibro-inflammatory lesions in nearly any organ, leading to organ dysfunction and failure. The IgG4-RD Responder Index (RI) was developed to help investigators assess the efficacy of treatment in a structured manner. We sought to validate the RI in a multi-national investigation. The RI guides investigators through assessments of disease activity and damage in 25 domains, incorporating higher weights for disease manifestations that require treatment urgently or that worsen despite treatment. After a training exercise, investigators reviewed 12 written IgG4-RD vignettes (mean length: 279 words, range: 76-511 words) based upon real patients. Investigators calculated both an RI score as well as a physician global assessment (PGA) for each vignette. Three investigators used the RI on fifteen patients followed over serial visits after treatment. We assessed inter- and intra-rater reliability, precision, validity, and responsiveness. Twenty-six physician-investigators included representatives from 6 specialties and 9 countries. The inter-rater and intra-rater reliabilities of the RI were strong (0.88 and 0.69, respectively) and superior to those of the PGA. Correlations (construct validity) between the RI and PGA were high (Spearman's r=0.9, Preliable disease activity assessment tool that can be used to measure response to therapy. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  6. Listeria monocytogenes in RTE foods marketed in Italy: prevalence and automated EcoRI ribotyping of the isolates.

    Science.gov (United States)

    Meloni, Domenico; Galluzzo, Pietro; Mureddu, Anna; Piras, Francesca; Griffiths, Mansel; Mazzette, Rina

    2009-02-15

    The aims of the present study were: (a) to investigate the prevalence and the enumeration of Listeria monocytogenes in 200 samples of ready to eat (RTE) foods of animal and vegetal origin collected from different outlets and processing plants in Sardinia; (b) to characterize the isolates by phenotypical and molecular methods; (c) to analyze a subset of 42 L. monocytogenes by automated EcoRI ribotyping in order to predict the strain's potential virulence for humans. The strains were isolated from: smoked fish products, cooked marinated products, meat products and pre-packaged mixed vegetable salads. Of the samples tested, 22% were positive for Listeria spp. The prevalence of L. monocytogenes was 9.5%, while the level of L. monocytogenes in the positive samples was 93%), belonging to 17 different DuPont Identification Library Codes (DUP-IDs) clones. The Simpson's numerical index of discrimination was 0.911. Cluster analysis pointed out a high similarity among strains isolated from meat, fish, and vegetables of different origin. These results confirmed the existence of a widespread population of L. monocytogenes, characterized by highly related strains existing in different geographical areas. 65% of these strains belonged to lineage II (serotypes 1/2a and 1/2c), subtypes known to be associated with sporadic human listeriosis outbreaks. The remaining 35% of the isolates (serotypes 1/2b, 3b and 4b) were allocated to lineage I and belong to distinct clonal groups (DUP-ID 1038 and 1042), which again have been associated with several outbreaks of human listeriosis. Neither atypical profiles nor lineage III strains were found. EcoRI ribotyping was confirmed as a rapid and reliable method for L. monocytogenes typing, providing useful data for epidemiologic and clonality surveys of L. monocytogenes strains isolated from RTE foods.

  7. Higher Total Protein Intake and Change in Total Protein Intake Affect Body Composition but Not Metabolic Syndrome Indexes in Middle-Aged Overweight and Obese Adults Who Perform Resistance and Aerobic Exercise for 36 Weeks.

    Science.gov (United States)

    Campbell, Wayne W; Kim, Jung Eun; Amankwaah, Akua F; Gordon, Susannah L; Weinheimer-Haus, Eileen M

    2015-09-01

    Studies assessing the effects of protein supplementation on changes in body composition (BC) and health rarely consider the impact of total protein intake (TPro) or the change in TPro (CTPro) from participants' usual diets. This secondary data analysis assessed the impact of TPro and CTPro on changes in BC and metabolic syndrome (MetS) indexes in overweight and obese middle-aged adults who participated in an exercise training program. Men and women [n = 117; age: 50 ± 0.7 y, body mass index (BMI; in kg/m(2)): 30.1 ± 0.3; means ± SEs] performed resistance exercise 2 d/wk and aerobic exercise 1 d/wk and consumed an unrestricted diet along with 200-kcal supplements (0, 10, 20, or 30 g whey protein) twice daily for 36 wk. Protein intake was assessed via 4-d food records. Multiple linear regression model and stratified analysis were applied for data analyses. Among all subjects, TPro and CTPro were inversely associated (P exercise training, higher TPro promoted positive changes in BC but not in MetS indexes in overweight and obese middle-aged adults. Changes in TPro from before to during the intervention also influenced BC responses and should be considered in future research when different TPro is achieved via diet or supplements. This trial was registered at clinicaltrials.gov as NCT00812409. © 2015 American Society for Nutrition.

  8. SaFaRI: sacral nerve stimulation versus the FENIX magnetic sphincter augmentation for adult faecal incontinence: a randomised investigation.

    Science.gov (United States)

    Williams, Annabelle E; Croft, Julie; Napp, Vicky; Corrigan, Neil; Brown, Julia M; Hulme, Claire; Brown, Steven R; Lodge, Jen; Protheroe, David; Jayne, David G

    2016-02-01

    Faecal incontinence is a physically, psychologically and socially disabling condition. NICE guidance (2007) recommends surgical intervention, including sacral nerve stimulation (SNS), after failed conservative therapies. The FENIX magnetic sphincter augmentation (MSA) device is a novel continence device consisting of a flexible band of interlinked titanium beads with magnetic cores that is placed around the anal canal to augment anal sphincter tone through passive attraction of the beads. Preliminary studies suggest the FENIX MSA is safe, but efficacy data is limited. Rigorous evaluation is required prior to widespread adoption. The SaFaRI trial is a National Institute of Health Research (NIHR) Health Technology Assessment (HTA)-funded UK multi-site, parallel group, randomised controlled, unblinded trial that will investigate the use of the FENIX MSA, as compared to SNS, for adult faecal incontinence resistant to conservative management. Twenty sites across the UK, experienced in the treatment of faecal incontinence, will recruit 350 patients randomised equally to receive either SNS or FENIX MSA. Participants will be followed-up at 2 weeks post-surgery and at 6, 12 and 18 months post-randomisation. The primary endpoint is success, as defined by device in use and ≥50 % improvement in the Cleveland Clinic Incontinence Score (CCIS) at 18 months post-randomisation. Secondary endpoints include complications, quality of life and cost effectiveness. SaFaRI will rigorously evaluate a new technology for faecal incontinence, the FENIX™ MSA, allowing its safe and controlled introduction into current clinical practice. These results will inform the future surgical management of adult faecal incontinence.

  9. AP Index

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Planetary Amplitude index - Bartels 1951. The a-index ranges from 0 to 400 and represents a K-value converted to a linear scale in gammas (nanoTeslas)--a scale that...

  10. Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice.

    Directory of Open Access Journals (Sweden)

    Carol L Murray

    Full Text Available Interleukin-1 (IL-1 is a key pro-inflammatory cytokine, produced predominantly by peripheral immune cells but also by glia and some neuronal populations within the brain. Its signalling is mediated via the binding of IL-1α or IL-1β to the interleukin-1 type one receptor (IL-1RI. IL-1 plays a key role in inflammation-induced sickness behaviour, resulting in depressed locomotor activity, decreased exploration, reduced food and water intake and acute cognitive deficits. Conversely, IL-1 has also been suggested to facilitate hippocampal-dependent learning and memory: IL-1RI(-/- mice have been reported to show deficits on tasks of visuospatial learning and memory. We sought to investigate whether there is a generalised hippocampal deficit in IL-1RI(-/- animals. Therefore, in the current study we compared wildtype (WT mice to IL-1RI(-/- mice using a variety of hippocampal-dependent learning and memory tasks, as well as tests of anxiety and locomotor activity. We found no difference in performance of the IL-1RI(-/- mice compared to WT mice in a T-maze working memory task. In addition, the IL-1RI(-/- mice showed normal learning in various spatial reference memory tasks including the Y-maze and Morris mater maze, although there was a subtle deficit in choice behaviour in a spatial discrimination, beacon watermaze task. IL-1RI(-/- mice also showed normal memory for visuospatial context in the contextual fear conditioning paradigm. In the open field, IL-1RI(-/- mice showed a significant increase in distance travelled and rearing behaviour compared to the WT mice and in the elevated plus-maze spent more time in the open arms than did the WT animals. The data suggest that, contrary to prior studies, IL-1RI(-/- mice are not robustly impaired on hippocampal-dependent memory and learning but do display open field hyperactivity and decreased anxiety compared to WT mice. The results argue for a careful evaluation of the roles of endogenous IL-1 in hippocampal

  11. AHP 10: "I, Ya ri a bsod, Am a Dog": The Life and Music of a Tibetan Mendicant Singer

    Directory of Open Access Journals (Sweden)

    Skal dbang skyid སྐལ་དབང་སྐྱིད།

    2011-06-01

    Full Text Available The life and music of Ya ri A bsod, a Tibetan composer and singer who lived in the early twentieth century, is described. Ya ri A bsod wandered through Tibetan nomad areas where contemporary Qinghai, Gansu, and Sichuan provinces meet in China. Texts and transcribed melodies of Ya ri A bsod songs are presented. These songs are contextualized in terms of their contemporary transmission, and the historical and autobiographical circumstances of their composition.

  12. Bacteria and viruses modulate FcεRI-dependent mast cell activity 

    Directory of Open Access Journals (Sweden)

    Aleksandra Słodka

    2013-03-01

    Full Text Available Undoubtedly, mast cells play a central role in allergic processes. Specific allergen cross-linking of IgE bound to the high affinity receptors (FcεRI on the mast cell surface leads to the release of preformed mediators and newly synthesized mediators, i.e. metabolites of arachidonic acid and cytokines. More and more data indicate that bacteria and viruses can influence FcεRI-dependent mast cell activation. Some bacterial and viral components can reduce the surface expression of FcεRI. There are also findings that ligation of Toll-like receptors (TLRs by bacterial or viral antigens can affect IgE-dependent mast cell degranulation and preformed mediator release as well as eicosanoid production. The synergistic interaction of TLR ligands and allergen can also modify cytokine synthesis by mast cells stimulated via FcεRI. Moreover, data suggest that specific IgE for bacterial or viral antigens can influence mast cell activity. What is more, some bacterial and viral components or some endogenous proteins produced during viral infection can act as superantigens by interacting with the VH3 domain of IgE. All these observations indicate that bacterial and viral infections modify the course of allergic diseases by affecting FcεRI-dependent mast cell activation. 

  13. Measurement of refractive index by nanoparticle tracking analysis reveals heterogeneity in extracellular vesicles

    Directory of Open Access Journals (Sweden)

    Chris Gardiner

    2014-11-01

    Full Text Available Introduction: Optical techniques are routinely used to size and count extracellular vesicles (EV. For comparison of data from different methods and laboratories, suitable calibrators are essential. A suitable calibrator must have a refractive index (RI as close to that of EV as possible but the RI of EV is currently unknown. To measure EV, RI requires accurate knowledge of size and light scattering. These are difficult to measure as most EVs cannot be resolved by light microscopy and their diameter is smaller than the wavelength of visible light. However, nanoparticle tracking analysis (NTA provides both size and relative light scattering intensity (rLSI values. We therefore sought to determine whether it was possible to use NTA to measure the RI of individual EVs. Methods: NTA was used to measure the rLSI and size of polystyrene and silica microspheres of known size and RI (1.470 and 1.633, respectively and of EV isolated from a wide range of cells. We developed software, based on Mie scattering code, to calculate particle RI from the rLSI data. This modelled theoretical scattering intensities for polystyrene and silica microspheres of known size (100 and 200 nm and RI. The model was verified using data from the polystyrene and silica microspheres. Size and rLSI data for each vesicle were processed by the software to generate RI values. Results: The following modal RI measurements were obtained: fresh urinary EV 1.374, lyophilised urinary EV 1.367, neuroblastoma EV 1.393, blood EV 1.398, EV from activated platelets 1.390, small placental EV 1.364–1.375 and 1.398–1.414 for large placental EV (>200 nm. Large placental EV had a significantly higher RI than small placental EV (p1.40 were observed for some large (>200 nm microvesicles. Conclusion: This method for measuring EV RI will be useful for developing appropriate calibrators for EV measurement.

  14. ri Pihl usub, et sotsid suudavad Tallinna juhtimist muuta / Urmas Seaver ; kommenteerinud Remo Holsmer ja Indrek Raudne

    Index Scriptorium Estoniae

    Seaver, Urmas, 1973-

    2009-01-01

    Sotsiaaldemokraatide juht Jüri Pihl ja Keskerakonna liider Edgar Savisaar allkirjastasid Tallinna juhtimise koalitsioonileppe. Vt. samas: Mõned olulisemad lubadused koalitsioonileppest Tallinna juhtimiseks 2009-2013

  15. ri Talvet Juhan Liivi radadel / Jüri Talvet on the Trails of Juhan Liiv

    Directory of Open Access Journals (Sweden)

    Tanar Kirs

    2016-12-01

    Full Text Available Teesid: Käesolev uurimus põhineb Jüri Talveti juubeliüritusel peetud ettekandel ning keskendub professori Liivi-alase tegevuse käsitlemisele. Artiklis tutvustan Talveti Liivi-tõlgenduse uudseid ja vähemärgatud detaile, mis kajastuvad tema koostatud Liivi luule väljaannetes ja nendega ühenduses olevates kriitilistes käsitlustes. Siinjuures tahan näidata, et Talvet avaldab Liivi luulet teistsuguses võtmes ja teisendab oluliselt seda normi, mille vahendusel Liivi luulet tänapäeval tuntakse.   The article addresses Jüri Talvet’s interpretation of poetry by Juhan Liiv (1864–1913. Its focus lies on a collection of Liiv’s poetry Snow Drifts, I Sing: Selected Poems (Lumi tuiskab, mina laulan: Valik luulet, 2013 compiled by Talvet. I shall compare this book with the most extensive volume of Liiv’s poetry of the previous century With and Without You (Sinuga ja sinuta, 1989 edited by Aarne Vinkel, which has had a major role in the shaping of the norms that serve as a basis for understanding Liiv’s work in recent times. The article observes how these volumes mediate Liiv’s poetry and the way Talvet transposes its earlier publishing standards. More particularly, I will analyse the poetry collection edited by Talvet from five perspectives: I will map the new texts and text fragments included in the work, discuss Talvet’s corrections and highlight the omitted fragments and full texts. Such specific treatment can be narrowed down to three broader topics: what new additions Talvet makes to the known textual body of Liiv’s poems (new texts; what changes he makes to previously published poems (textual additions, corrections and omissions; what he has left out (omitted texts. Talvet adds a great number of texts to the known body of Liiv’s poems. The poetry book Snow Drifts, I Sing contains over 20 poems that are not included in With and Without You; furthermore, Talvet publishes a number of new pieces of poetry. These texts have

  16. ri Talvet maailmaluule tõlgendajana / Jüri Talvet’s Interpretations of World Poetry

    Directory of Open Access Journals (Sweden)

    Lauri Pilter

    2016-12-01

    Full Text Available Teesid: Tartu Ülikooli maailmakirjanduse professori, luuletaja, kirjandusteadlase ja hispaaniakeelse kirjanduse spetsialisti Jüri Talveti tõlketegevuse viljade hulka kuulub luulet ja proosat nii sajandeid vanast Hispaania klassikast kui ka 20. sajandil või tänapäeval romaani keeltes või inglise keeles loodud teostest. Käesolev artikkel keskendub sellele, kuidas professor Talvet on tõlgendanud luule ja poeetika, kuid ka kirjandusajaloo, iseäranis barokk-kirjanduse alaseid küsimusi oma kirjandusteaduslikes esseedes. Vaadeldakse ka tema tõlketegevuse mahtu ja tõlketöö põhimõtteid.   Jüri Talvet (born in 1945 is a poet and a scholar of comparative literature, Chair Professor of World Literature at the University of Tartu. His numerous translations of poetry and poetical fiction from the Romance languages and, to a lesser extent, from English, reflect his views on world poetry. Those views are also expressed in his theoretical writings from the years of 1977 to 2015. Having studied English literature as the main subject at the University of Tartu, he early developed an interest in Spanish, in other Iberian languages, and in the Iberoamerican literatures. His translations from that area include works from medieval and early modern literature as well as notable literary achievements from the 20th century and the contemporary era. Talvet’s interpretations of Federico García Lorca and the “Latin American boom” authors are supported by profound insights into the philosophy, aesthetics, and poetics of the 17th century Spanish Baroque literature, known as the literary Golden Age of Spain. The influence which Talvet’s activities have exerted has widened the horizons of Estonia’s literary culture: while in the early 20th century, the previous German, Russian and Finnish leanings were supplemented by orientations to, and translations from, French and Italian literatures, Talvet has helped to enrich the Estonian literary landscape

  17. Antimicrobial multiple resistance index, minimum inhibitory concentrations, and extended-spectrum beta-lactamase producers of Proteus mirabilis and Proteus vulgaris strains isolated from domestic animals with various clinical manifestations of infection

    Directory of Open Access Journals (Sweden)

    Vanessa Zappa

    2017-05-01

    Full Text Available Proteus spp. are opportunistic multidrug resistant enterobacteria associated with diverse clinical diseases in domestic animals. However, Proteus infections in domestic animals are often misdiagnosed or considered contaminants in microbiological cultures rather than a primary agent of disease. Descriptions of Proteus infections in domestic animals are typically restricted to case reports, retrospective studies, or surveillance of other microorganisms. The present study investigated multiple antibiotic resistance indices, minimum inhibitory concentrations (MICs, and ESBL production in 73 strains of Proteus mirabilis (n = 69 and Proteus vulgaris (n = 4 isolated from domestic animals with various clinical manifestations. In dogs, the pathogen was most commonly associated with cystitis (48.21, enteritis (21.42%, otitis (14.29%, and conjunctivitis (3.57%. In bovines, the microorganism was predominant in cases of enteritis (22.22%, abscess (11.11%, otitis (11.11%, omphalitis (11.11%, and peritonitis (11.11%, and in organ fragments (11.11%. In equines (50.0% and cats (100.0%, diarrhea was the main clinical sign. In vitro standard disk diffusion assay showed that the most effective antimicrobials against the isolates were imipenem (98.63, norfloxacin (95.89, amikacin (95.89, levofloxacin (90.41, ceftriaxone (87.64, and florfenicol (87.67. In contrast, the isolates commonly showed resistance to novobiocin (95.89, azithromycin (57.53, and trimethropim/sulfamethoxazole (39.73. Among the 73 isolates, the efficacy of amoxicillin/clavulanic acid, gentamicin, ceftriaxone, and ciprofloxacin according to MICs was 87.67%, 86.30%, 84.93%, and 82.19%, respectively. The MIC50 values of amoxicillin/clavulanic acid, ceftriaxone, ciprofloxacin, and gentamicin were, respectively, 1.0, 0.004, 0.03, and 1.0 µg/mL. Thirty-three strains (45.21% showed a antimicrobial multiple resistance index of ? 0.3. Multidrug resistance profiles of isolates were observed most frequently

  18. The erudite humility of the historian: the 'critical epistemology' of Georges Lantéri-Laura.

    Science.gov (United States)

    Basso Lorini, Elisabetta

    2017-06-01

    This paper analyses the historical and epistemological work of the French psychiatrist Georges Lantéri-Laura (1930-2004) within the context of the French 'tradition' of history and philosophy of sciences, with special reference to Georges Canguilhem and Michel Foucault. After an introduction devoted to a critical survey of the most recent works on the history and historiography of psychiatry in French, the paper outlines Lantéri-Laura's approach by focusing especially on the role played by the methodological concept of 'semiology' as regards the relation between medicine and psychiatry. The last part of the paper draws attention to the relation between the history and philosophy of psychiatry in light of Lantéri-Laura's 'critical epistemology'.

  19. Thermal characteristic of insulation for optimum design of RI transport package

    International Nuclear Information System (INIS)

    Lee, J. C.; Bang, K. S.; Seo, K. S.

    2002-01-01

    A package to transport the high level radioactive materials in required to withstand the hypothetical accident conditions as well as normal transport conditions according to IAEA and domestic regulations. The regulations require that the package should maintain the shielding, thermal and structural integrities to release no radioactive material. Thermal characteristics of insulations were evaluated and optimum insulation thickness was deduced for RI transport package. The package has a maximum capacity of 600 Curies for Ir-192 sealed source. The insulation thickness was decided with 10 mm of polyurethane form to maintain the thermal safety under fire accident condition. Thermal analysis was carried out for RI transport package, and it was shown that the thermal integrity of the package was maintained. The results obtained this study will be applied to a basic data for design of RI transport cask

  20. Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation

    DEFF Research Database (Denmark)

    Jensen, Bettina M; Beaven, Michael A; Iwaki, Shoko

    2008-01-01

    Although primarily required for the growth, differentiation, and survival of mast cells, Kit ligand (stem cell factor) is also required for optimal antigen-mediated mast cell activation. Therefore, concurrent inhibition of Kit- and FcepsilonRI-mediated signaling would be an attractive approach...... characterized Kit inhibitor imatinib mesylate (imatinib). In contrast to imatinib, however, hypothemycin also effectively inhibited FcepsilonRI-mediated degranulation and cytokine production in addition to the potentiation of these responses via Kit. The effect of hypothemycin on Kit-mediated responses could...... be explained by its inhibition of Kit kinase activity, whereas the inhibitory effects on FcepsilonRI-dependent signaling were at the level of Btk activation. Because hypothemycin also significantly reduced the mouse passive cutaneous anaphylaxis response in vivo, these data provide proof of principle...

  1. The value of RI scintigraphy and angiography in small intestinal bleeding; Report of eight cases

    Energy Technology Data Exchange (ETDEWEB)

    Kurosawa, Susumu; Kuwata, Hajime; Kushibiki, Kyoko; Akimoto, Kimihiko; Hashimoto, Toshiyuki; Kojima, Toshiya (Showa General Hospital, Kodaira, Tokyo (Japan))

    1991-07-01

    We retrospectively reviewed eight cases of small intestinal bleeding and assessed the value of RI scintigraphy and angiography in diagnosing the bleeding site. The patients' average age was 56.2 years. Chief complaint was melena of variable degree. In most cases neither upper endoscopy nor colonoscopy was diagnostic. RI scientigraphy (Tc-99 labeled human serum albumin) showed 75% of positive rate whereas angiography showed 66.7% (4/6) of positive rate. All four cases of leiomyosarcoma and leiomyoma demonstrated hypervascular stain and/or extra-vasation in angiography whereas RI scintigraphy failed to detect active gastrointestinal bleeding in 2 of the 4 cases. Therefore angiography was considered useful for the detection of bleeding from leiomyoma and leiomyosarcoma which are often hypervascular. Scintigraphy is thought of most value in the demonstration of small amount of bleeding with minimum vascular abnormality. (author).

  2. AA Index

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The geomagnetic aa index provides a long climatology of global geomagnetic activity using 2 antipodal observatories at Greenwich and Melbourne- IAGA Bulletin 37,...

  3. Walkability Index

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Walkability Index dataset characterizes every Census 2010 block group in the U.S. based on its relative walkability. Walkability depends upon characteristics of...

  4. Diversity Index

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — This map service summarizes racial and ethnic diversity in the United States in 2012.The Diversity Index shows the likelihood that two persons chosen at random from...

  5. AUTHOR INDEX

    Indian Academy of Sciences (India)

    a granitic terrain of southern India using factor analysis and GIS. 1059. Radhakrishna M see Dev Sheena V .... Landslide susceptibility analysis using Probabilistic. Certainty Factor ... index via entropy-difference analysis. 687. Yidana Sandow ...

  6. A research on the empowerment plan for specialist in RI-biomics field

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Wo Ho; Park, Tai Jin; Yeom, Yu Sun [Korea Association for Radiation Application, Seoul (Korea, Republic of); Park, Sang Hyun [Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of)

    2014-12-15

    Increasing utilization of radiation and RI (Radioisotope) in nuclear industry including non-power area has achieved sustainable development of radiation industry. Industries are no longer confined by a single technology or abilities but expanded for application gradually. RIBiomics fields are one of the convergence technology that is recognized on a high-tech industry. Unlike the conventional industry, RI-Biomics field needs to various specialists to perform related task. There is no domestic training program to educate the whole process. This study aims to suggest the plan for improvement of practical skills for specialists in RI-Biomics through development of our training program. For this purpose, we have first investigated the opinion about classification scheme from experts and then analyzed the results in order to reflecting our training program. Based on analyzed results, conformity assessment was executed to organize curriculum through status of constructed device and instructor in domestic. Our training program was performed jointly with KAERI (Korea Atomic Energy Research Institute). RI-Biomics center is prepared with facilities of overall experiment to improve quality of education. Due to the fact that specialists have routine task, we organized a five-day short course to reflect temporal difficulties. We performed a trial operation to 6 participants in RI-Biomics field. Through the survey for the specialists who participated in the program, we evaluated the efficiency of our training program. The results showed that participants were satisfied with the organized curriculum and educational materials. Therefore, our program is expected to be utilized as basic research data to develop feasible program for policy development and to improve practical skills in RI-Biomics.

  7. A research on the empowerment plan for specialist in RI-biomics field

    International Nuclear Information System (INIS)

    Shin, Wo Ho; Park, Tai Jin; Yeom, Yu Sun; Park, Sang Hyun

    2014-01-01

    Increasing utilization of radiation and RI (Radioisotope) in nuclear industry including non-power area has achieved sustainable development of radiation industry. Industries are no longer confined by a single technology or abilities but expanded for application gradually. RIBiomics fields are one of the convergence technology that is recognized on a high-tech industry. Unlike the conventional industry, RI-Biomics field needs to various specialists to perform related task. There is no domestic training program to educate the whole process. This study aims to suggest the plan for improvement of practical skills for specialists in RI-Biomics through development of our training program. For this purpose, we have first investigated the opinion about classification scheme from experts and then analyzed the results in order to reflecting our training program. Based on analyzed results, conformity assessment was executed to organize curriculum through status of constructed device and instructor in domestic. Our training program was performed jointly with KAERI (Korea Atomic Energy Research Institute). RI-Biomics center is prepared with facilities of overall experiment to improve quality of education. Due to the fact that specialists have routine task, we organized a five-day short course to reflect temporal difficulties. We performed a trial operation to 6 participants in RI-Biomics field. Through the survey for the specialists who participated in the program, we evaluated the efficiency of our training program. The results showed that participants were satisfied with the organized curriculum and educational materials. Therefore, our program is expected to be utilized as basic research data to develop feasible program for policy development and to improve practical skills in RI-Biomics

  8. Intelligent indexing

    International Nuclear Information System (INIS)

    Farkas, J.

    1992-01-01

    In this paper we discuss the relevance of artificial intelligence to the automatic indexing of natural language text. We describe the use of domain-specific semantically-based thesauruses and address the problem of creating adequate knowledge bases for intelligent indexing systems. We also discuss the relevance of the Hilbert space ι 2 to the compact representation of documents and to the definition of the similarity of natural language texts. (author). 17 refs., 2 figs

  9. Intelligent indexing

    Energy Technology Data Exchange (ETDEWEB)

    Farkas, J

    1993-12-31

    In this paper we discuss the relevance of artificial intelligence to the automatic indexing of natural language text. We describe the use of domain-specific semantically-based thesauruses and address the problem of creating adequate knowledge bases for intelligent indexing systems. We also discuss the relevance of the Hilbert space {iota}{sup 2} to the compact representation of documents and to the definition of the similarity of natural language texts. (author). 17 refs., 2 figs.

  10. SUBJECT INDEX

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    2.5D Simulation of basin-edge effects on the ground ... sity, anomalous resistivity and parallel electric field .... Late Quaternary sea level and environmental ... Energy. Statistical parameters of Bhuj earthquake sequence of January 26th, 2001.

  11. RFI/RI work plan for the Road A Chemical Basin 904-111G

    International Nuclear Information System (INIS)

    Kmetz, T.F.

    2000-01-01

    This Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI)/Remedial Investigation (RI) Work Plan has been prepared for the Road A Chemical Basin Operable Unit (RdACB OU) (904-111G). This unit is subject to the requirements of both RCRA and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). This Work Plan presents the initial evaluation of existing unit data, applicable background data, the regulatory framework for the unit investigation, and the evaluations and decisions made during the determination of the scope and objectives of the planned Remedial Investigation/Feasibility Study (RI/FS) activities

  12. Comparison of cerebrospinal fluid dynamics studied by computed tomography (CT) and radioisotope (RI) cisternography

    International Nuclear Information System (INIS)

    Tamaki, N.; Kanazawa, Y.; Asada, M.; Kusunoki, T.; Matsumoto, S.

    1978-01-01

    CT and RI cisternography were done on 55 cases with normal and abnormal CSF circulation. Of 19 cases in which both studies were done, 14 cases disclosed a good correspondence. The remaining five cases showed no correspondence because of technical failure. Analyzing the results, CT cisternography demonstrates pathology of the CSF dynamics in a more precise and quantitative manner than RI cisternography does. Metrizamide CT cisternography will soon be the most reliable method of investigation for the evaluation of the CSF kinetics. (orig.) [de

  13. RFI/RI work plan for the Road A Chemical Basin 904-111G

    Energy Technology Data Exchange (ETDEWEB)

    Kmetz, T.F.

    2000-03-07

    This Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI)/Remedial Investigation (RI) Work Plan has been prepared for the Road A Chemical Basin Operable Unit (RdACB OU) (904-111G). This unit is subject to the requirements of both RCRA and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). This Work Plan presents the initial evaluation of existing unit data, applicable background data, the regulatory framework for the unit investigation, and the evaluations and decisions made during the determination of the scope and objectives of the planned Remedial Investigation/Feasibility Study (RI/FS) activities.

  14. BV RI CCD photometry of 361,281 objects in the field of M 31

    Science.gov (United States)

    Magnier, E. A.; Lewin, W. H. G.; Van Paradijs, J.; Hasinger, G.; Jain, A.; Pietsch, W.; Truemper, J.

    1992-01-01

    Deep BV RI CCD photometry was performed on a 1 sq deg region of M 31. A catalog of photometry and astrometry of a total of 361,281 stars is presented, with typical completion limits of BV RI = (22.3, 22.2, 22.2, 20.9). Photometric accuracy is about 2 percent at V = 19. This catalog allows detailed studies of stellar populations and reddening. The data are currently being used to assist in finding the optical counterparts of Einstein and ROSAT X-ray sources.

  15. Endurance test for IR rig for RI production assembly (test procedure)

    International Nuclear Information System (INIS)

    Chung, Heung June; Ryu, Jeong Soo

    2000-08-01

    This test procedure details the test loop, test method, and test procedure for pressure drop, vibration and endurance test of IR Rig for RI production. From the pressure drop test, the hydraulic design requirements of the capsule are verified. HANARO limit condition is checked and the compatibility with HANARO core is verified. From flow induced vibration test vibration frequency and displacement are investigated. The wear of IR Rig is investigated through endurance test, and these data are used to evaluate the expected wear at maximum resident time of the IR Rig for RI production

  16. Äriõigus 2006 : seaduste tekstid seisuga 01. 03. 2006 / koost. Andrus Lauren

    Index Scriptorium Estoniae

    2006-01-01

    Kaanel sisu: Äriseadustik. Tulundusühistuseadus. TsÜS. Euroopa äriühingu (SE) määrus. Euroopa äriühingu (SE) määruse RS. SE töötajate kaasamise seadus. Euroopa ühistu (SCE) määrus. Euroopa ühistu (SCE) määruse RS. EMHÜ määrus. EMHÜ määruse RS. Konkurentsiseadus. Majandustegevuse registri seadus. Väärtpaberite keskregistri seadus. - Kommentaarid lk. 256-276

  17. Automated procedure for candidate compound selection in GCMS metabolomics based on prediction of Kovats retention index

    NARCIS (Netherlands)

    Mihaleva, V.V.; Verhoeven, H.A.; Vos, de C.H.; Hall, R.D.; Ham, van R.C.H.J.

    2009-01-01

    Motivation: Matching both the retention index (RI) and the mass spectrum of an unknown compound against a mass spectral reference library provides strong evidence for a correct identification of that compound. Data on retention indices are, however, available for only a small fraction of the

  18. Insulin resistance index (HOMA-IR) levels in a general adult population: curves percentile by gender and age. The EPIRCE study.

    Science.gov (United States)

    Gayoso-Diz, Pilar; Otero-Gonzalez, Alfonso; Rodriguez-Alvarez, María Xosé; Gude, Francisco; Cadarso-Suarez, Carmen; García, Fernando; De Francisco, Angel

    2011-10-01

    To describe the distribution of HOMA-IR levels in a general nondiabetic population and its relationships with metabolic and lifestyles characteristics. Cross-sectional study. Data from 2246 nondiabetic adults in a random Spanish population sample, stratified by age and gender, were analyzed. Assessments included a structured interview, physical examination, and blood sampling. Generalized additive models (GAMs) were used to assess the effect of lifestyle habits and clinical and demographic measurements on HOMA-IR. Multivariate GAMs and quantile regression analyses of HOMA-IR were carried out separately in men and women. This study shows refined estimations of HOMA-IR levels by age, body mass index, and waist circumference in men and women. HOMA-IR levels were higher in men (2.06) than women (1.95) (P=0.047). In women, but not men, HOMA-IR and age showed a significant nonlinear association (P=0.006), with increased levels above fifty years of age. We estimated HOMA-IR curves percentile in men and women. Age- and gender-adjusted HOMA-IR levels are reported in a representative Spanish adult non-diabetic population. There are gender-specific differences, with increased levels in women over fifty years of age that may be related with changes in body fat distribution after menopause. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  19. Homa1-ir And Homa2-ir Indexes In Identifying Insulin Resistance And Metabolic Syndrome - Brazilian Metabolic Syndrome Study (brams) [Índices Homa1-ir E Homa2-ir Para Identificação De Resistência à Insulina E Síndrome Metabólica - Estudo Brasileiro De Síndrome Metabólica (brams)

    OpenAIRE

    Geloneze B.; Vasques A.C.J.; Stabe C.F.C.; Pareja J.C.; de Lima Rosado L.E.F.P.; de Queiroz E.C.; Tambascia M.A.

    2009-01-01

    Objective: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. Methods: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. Results: In the he...

  20. Virginia ESI: INDEX (Index Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains vector polygons representing the boundaries of all hardcopy cartographic products produced as part of the Environmental Sensitivity Index...

  1. Tsw gene-based resistance is triggered by a functional RNA silencing suppressor protein of the Tomato spotted wilt virus

    NARCIS (Netherlands)

    Ronde, de D.; Butterbach, P.B.E.; Lohuis, H.; Hedil, M.; Lent, van J.W.M.; Kormelink, R.J.M.

    2013-01-01

    As a result of contradictory reports, the avirulence (Avr) determinant that triggers Tsw gene-based resistance in Capsicum annuum against the Tomato spotted wilt virus (TSWV) is still unresolved. Here, the N and NSs genes of resistance-inducing (RI) and resistance-breaking (RB) isolates were cloned

  2. Systemic immune-inflammation index predicting chemoradiation resistance and poor outcome in patients with stage III non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Yu-Suo Tong

    2017-10-01

    Full Text Available Abstract Background There is increasing evidence that the existence of systemic inflammation response is correlated with poor prognosis in several solid tumors. The aim of this retrospective study was to investigate the association between systemic immune-inflammation index (SII and therapy response and overall survival in patients with stage III non-small cell lung cancer (NSCLC. The prognostic values of neutrophil to lymphocyte ratio (NLR, platelet to lymphocyte ratio (PLR, and prognostic nutritional index (PNI were also evaluated. Methods In total, 332 patients with new diagnosis of stage III NSCLC were included in this retrospective analysis. SII was defined as platelet counts × neutrophil counts/lymphocyte counts. Receiver operating characteristic (ROC curve was used to evaluate the optimal cut-off value for SII, NLR, PLR and PNI. Univariate and multivariate survival analysis were performed to identify the factors correlated with overall survival. Results Applying cut-offs of ≥ 660 (SII, ≥ 3.57 (NLR, ≥ 147 (PLR, ≤ 52.95 (PNI, SII ≥ 660 was significantly correlated with worse ECOG PS (< 0.001, higher T stage (< 0.001, advanced clinical stage (p = 0.019, and lower response rate (p = 0.018. In univariate analysis, SII ≥ 660, NLR ≥ 3.57, PLR ≥ 147, and PNI ≤ 52.95 were significantly associated with worse overall survival (p all < 0.001. Patients with SII ≥ 660 had a median overall survival of 10 months, and patients with SII < 660 showed a median overall survival of 30 months. In multivariate analysis only ECOG PS (HR, 1.744; 95% CI 1.158–2.626; p = 0.008, T stage (HR, 1.332; 95% CI 1.032–1.718; p = 0.028, N stage (HR, 1.848; 95% CI 1.113–3.068; p = 0.018, SII (HR, 2.105; 95% CI 1.481–2.741; p < 0.001 and NLR ≥ 3.57 (HR, 1.934; 95% CI 1.448–2.585; p < 0.001 were independently correlated with overall survival. Conclusions This study demonstrates that the SII is an

  3. Apolipoprotein E4, Gender, Body Mass Index, Inflammation, Insulin Resistance, and Air Pollution Interactions: Recipe for Alzheimer's Disease Development in Mexico City Young Females.

    Science.gov (United States)

    Calderón-Garcidueñas, Lilian; de la Monte, Suzanne M

    2017-01-01

    Given the epidemiological trends of increasing Alzheimer's disease (AD) and growing evidence that exposure and lifestyle factors contribute to AD risk and pathogenesis, attention should be paid to variables such as air pollution, in order to reduce rates of cognitive decline and dementia. Exposure to fine particulate matter (PM2.5) and ozone (O3) above the US EPA standards is associated with AD risk. Mexico City children experienced pre- and postnatal high exposures to PM2.5, O3, combustion-derived iron-rich nanoparticles, metals, polycyclic aromatic hydrocarbons, and endotoxins. Exposures are associated with early brain gene imbalance in oxidative stress, inflammation, innate and adaptive immune responses, along with epigenetic changes, accumulation of misfolded proteins, cognitive deficits, and brain structural and metabolic changes. The Apolipoprotein E (APOE) 4 allele, the most prevalent genetic risk for AD, plays a key role in the response to air pollution in young girls. APOE 4 heterozygous females with >75% to <94% BMI percentiles are at the highest risk of severe cognitive deficits (1.5-2 SD from average IQ). This review focused on the relationships between gender, BMI, systemic and neural inflammation, insulin resistance, hyperleptinemia, dyslipidemia, vascular risk factors, and central nervous system involvement in APOE4 urbanites exposed to PM2.5 and magnetite combustion-derived iron-rich nanoparticles that can reach the brain. APOE4 young female heterozygous carriers constitute a high-risk group for a fatal disease: AD. Multidisciplinary intervention strategies could be critical for prevention or amelioration of cognitive deficits and long-term AD progression in young individuals at high risk.

  4. Improving the efficiency of copper indium gallium (Di-)selenide (CIGS) solar cells through integration of a moth-eye textured resist with a refractive index similar to aluminum doped zinc oxide

    Energy Technology Data Exchange (ETDEWEB)

    Burghoorn, M.; Kniknie, B.; Deelen, J. van; Ee, R. van [The Netherlands Organisation for Applied Scientific Research (TNO), De Rondom 1, 5612 AP, Eindhoven (Netherlands); Xu, M. [The Netherlands Organisation for Applied Scientific Research (TNO), De Rondom 1, 5612 AP, Eindhoven (Netherlands); Delft University of Technology, Optics Group, Van der Waalsweg 8, 2628 CH, Delft (Netherlands); Vroon, Z. [The Netherlands Organisation for Applied Scientific Research (TNO), De Rondom 1, 5612 AP, Eindhoven (Netherlands); Zuyd Hogeschool, Nieuw Eyckholt 300, 6419 DJ, Heerlen (Netherlands); Belt, R. van de [Kriya Materials BV, Urmonderbaan 22, 6167 RD, Geleen (Netherlands); Buskens, P., E-mail: pascal.buskens@tno.nl, E-mail: buskens@dwi.rwth-aachen.de [The Netherlands Organisation for Applied Scientific Research (TNO), De Rondom 1, 5612 AP, Eindhoven (Netherlands); DWI – Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056, Aachen (Germany)

    2014-12-15

    Textured transparent conductors are widely used in thin-film silicon solar cells. They lower the reflectivity at interfaces between different layers in the cell and/or cause an increase in the path length of photons in the Si absorber layer, which both result in an increase in the number of absorbed photons and, consequently, an increase in short-circuit current density (J{sub sc}) and cell efficiency. Through optical simulations, we recently obtained strong indications that texturing of the transparent conductor in copper indium gallium (di-)selenide (CIGS) solar cells is also optically advantageous. Here, we experimentally demonstrate that the J{sub sc} and efficiency of CIGS solar cells with an absorber layer thickness (d{sub CIGS}) of 0.85 μm, 1.00 μm and 2.00 μm increase through application of a moth-eye textured resist with a refractive index that is sufficiently similar to AZO (n{sub resist} = 1.792 vs. n{sub AZO} = 1.913 at 633 nm) to avoid large optical losses at the resist-AZO interface. On average, J{sub sc} increases by 7.2%, which matches the average reduction in reflection of 7.0%. The average relative increase in efficiency is slightly lower (6.0%). No trend towards a larger relative increase in J{sub sc} with decreasing d{sub CIGS} was observed. Ergo, the increase in J{sub sc} can be fully explained by the reduction in reflection, and we did not observe any increase in J{sub sc} based on an increased photon path length.

  5. Use of AFLP marker system on sugarcane somaclones to study their resistance to rust

    Directory of Open Access Journals (Sweden)

    María Ileana Oloriz

    2002-10-01

    Full Text Available AFLPs (amplified fragment length polymorphism was carried out from genomic DNA of five rust resistant sugar cane somaclons and their susceptible donor, Saccharum officinarum var B 4362, using three combinations of primers (EcoRI/aca: MseI/acc; EcoRI/aca: MseI/atg and EcoRI/aca: MseI/agg. Six polymorphic bands were obtained, two of these only appeared in the resistant genotypes, which are probably DNA sequences, related to rust resistance locus. These fragments have been cloned to study their nucleotide sequence and to investigate their roll in resistance mechanism develop by these mutants during Puccinia melanocephala infection. Key words: molecular markers, Puccinia. melanocephala, Saccharum

  6. 78 FR 55121 - Submission for Review: Self-Certification of Full-Time School Attendance for the School Year, RI...

    Science.gov (United States)

    2013-09-09

    ... Attendance for the School Year, RI 25-14 and Information; and Instructions for Completing the Self...-0032, Self-Certification of Full-Time School Attendance For The School Year, RI 25-14; and Information... technological collection techniques or other forms of information technology, e.g., permitting electronic...

  7. Transcription of Russian intonation ToRI, an interactive research tool and learning module on the internet

    NARCIS (Netherlands)

    Odé, C.

    2008-01-01

    This article discusses a new system for the Transcription of Russian Intonation, ToRI, on the Internet. Section 1 presents a general outline of the system. The terminology used in ToRI is defined in an online glossary, from which Section 2 gives the following examples: pitch accent and

  8. Tornide väljaku müüriäärse ala tulevik endiselt ebaselge / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2004-01-01

    Tallinna linna ja ehitusfirma Restor vaheline tüli linnamüüri äärse maa täisehitamise suhtes Suurtüki kvartalis pole lahendust leidnud. Linnaosavalitsus soovib müüri äärde parki ja tahab algatada ala detaiplaneeringut. Restoril on Plate ja Eppingi torni vahel ridaelamuboksid juba välja ehitatud

  9. 78 FR 52580 - Submission for Review: Request for Case Review for Enhanced Disability Annuity Benefit, RI 20-123

    Science.gov (United States)

    2013-08-23

    ... Disability Annuity Benefit, RI 20-123 AGENCY: U.S. Office of Personnel Management. ACTION: 60-Day notice and... Disability Annuity Benefit, RI 20-123. As required by the Paperwork Reduction Act of 1995, (Pub. L. 104-13... review the computations of disability annuities to include the formulae provided in law for individuals...

  10. New RTM/RI Resins for the HSCT

    Science.gov (United States)

    Harris, Frank W.

    1999-01-01

    In the first portion of this work, 1,2,3,3,4,4-hexafluoro-1,2-bis[4-(dimethylhydroxysilyl)phenoxy]cyclobutane and 1,2,3,3,4,4-hexafluoro-1,2-bis[3-(dimethylhydroxysilyl)phenoxy]cyclobutane were prepared and homopolymerized to afford polymers with excellent thermal stability and Tgs of 27 C and -12 C, respectively. Despite the moderately high wt% of fluorin in the polymer structure (23.8%), these polymers had poor fuel resistance. In fact, swelling measurements indicate that these polymers had apparent solubility parameters of about 18.2 J (exp 1/2) m (exp -3/2) (toluene). Copolymerization of the disilanol monomers with fluorosilicone monomers afforded copolymers containing 20-30 wt% of the perfluorocyclobutane-containing structure displayed adequate fuel resistance, enhanced thermal stability, and a Tg low enough to meet the requirements of a High Speed Civil Transport (HSCT) fuel tank sealant. In the second part of this work, trifluorovinylether-terminated oligomers were prepared and polymerized via cyclodimerization. Initially, an alpha, omega-silanol-terminated fluorosilicone was endcapped with trifluorovinylether end groups via a two-step synthetic sequence. The oligomer was thermally cyclodimerized to a polymer that displayed thermal stability similar to that of a fluorosilicone homopolymer. Second, 1,3-bis[4-trifluorovinyl(oxy)phenyl]-1,3-(3,3,3-trifluoropropyl)dimethyldisiloxane and 1,3-bis{3-trifluorovinyl(oxy)phenyl]-1,3-(3,3,3-trifluoropropyl)dimethyldisiloxane were prepared and cyclodimerized to afford polymers that contained pendant trifluoropropyl groups. The pendant trifluoropropyl groups did enhance solvent resistance in aliphatic hydrocarbon solvents, however, no improvement was observed in aromatic hydrocarbon solvents. These polymers also displayed excellent thermal stability. In the last part of this work, a series of monomers was prepared by the DCC-promoted esterification of 4-[trifluorovinyl(oxy)benzoic acid with alpha, omega

  11. Indexing mechanisms

    International Nuclear Information System (INIS)

    Wood, A.G.; Parker, G.E.; Berry, R.

    1976-01-01

    It is stated that the indexing mechanism described can be used in a nuclear reactor fuel element inspection rig. It comprises a tubular body adapted to house a canister containing a number of fuel elements located longtitudinally, and has two chucks spaced apart for displacing the fuel elements longitudinally in a stepwise manner, together with a plunger mechanism for displacing them successively into the chucks. A measuring unit is located between the chucks for measuring the diameter of the fuel elements at intervals about their circumferences, and a secondary indexing mechanism is provided for rotating the measuring unit in a stepwise manner. (U.K.)

  12. Valitsus tahab kaotada üüri piirmäärad / Anne Oja

    Index Scriptorium Estoniae

    Oja, Anne, 1970-

    2004-01-01

    Valitsus kiitis heaks eelnõu üüri piirmäärade kaotamise kohta. Tallinna linnavalitsus on piirmäärade kaotamise vastu, kuna see halvendaks abilinnapea Aivar Pärna sõnul oluliselt sundüürnike olukorda

  13. GarcÍa Lorca luulest ja Ain Kaalepi tõlkest / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1998-01-01

    Arvustus: GarcÍa Lorca, Federico. Mu kätes põleb tuli : valitud luuletused / tlk. ja saateks: Ain Kaalep. 2. tr. Tallinn : Vagabund, 1997. Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 442-453

  14. ri Arrak nüüdis- ja vanamuusikas / Igor Garšnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2011-01-01

    8. novembril Niguliste kirikus toimunud Hortus Musicuse Jüri Arraku 75. sünnipäevale pühendatud kontserdist, kus tulid esiettekandele Rene Eespere, Tõnis Kaumanni ja Peeter Vähi kunstnikule pühendatud uudisteosed

  15. 77 FR 16974 - Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI

    Science.gov (United States)

    2012-03-23

    ...-AA08 Special Local Regulations; Ocean State Tall Ships Festival 2012, Narragansett Bay, RI AGENCY... Island, for the Ocean State Tall Ships Festival 2012. This action is necessary to provide for the safety..., during the Ocean State Tall Ships Festival on July 6-9, 2012. These temporary special local regulations...

  16. Meie ühine mure on tervishoid / Jüri Ratas

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2008-01-01

    Ilmunud ka: Den za Dnjom 1. veebr. lk. 18. Põhjarannik 18. jaan. 2008, lk. 2, Severnoje Poberezhje 18. jaan. 2008, lk. 2, Den za Dnjom 18. jaan. 2008, lk. 2. Riigikogu aseesimees Jüri Ratas tunneb muret Eesti elanike tervise pärast

  17. Genealogy of gas cells for low-energy RI-beam production

    Energy Technology Data Exchange (ETDEWEB)

    Wada, Michiharu, E-mail: mw@riken.jp

    2013-12-15

    Highlights: • In order to overcome serious limitations in the universality of the traditional isotope separator on-line technique, various endeavors have been made on gas catcher cells for converting relativistic RI-beams from in-flight separators to low-energy RI-beams. • The origin of the gas catcher is found in the IGISOL (Ion guide isotope separator on-line) technique. • Many developments have been made over the years to overcome the various difficulties and drawbacks found in the IGISOL technique. -- Abstract: In order to overcome serious limitations in the universality of the traditional isotope separator on-line technique, various endeavors have been made on gas catcher cells for converting relativistic RI-beams from in-flight separators to low-energy RI-beams. The origin of the gas catcher is found in the IGISOL (Ion guide isotope separator on-line) technique. Many developments have been made over the years to overcome the various difficulties and drawbacks found in the IGISOL technique.

  18. Genealogy of gas cells for low-energy RI-beam production

    International Nuclear Information System (INIS)

    Wada, Michiharu

    2013-01-01

    Highlights: • In order to overcome serious limitations in the universality of the traditional isotope separator on-line technique, various endeavors have been made on gas catcher cells for converting relativistic RI-beams from in-flight separators to low-energy RI-beams. • The origin of the gas catcher is found in the IGISOL (Ion guide isotope separator on-line) technique. • Many developments have been made over the years to overcome the various difficulties and drawbacks found in the IGISOL technique. -- Abstract: In order to overcome serious limitations in the universality of the traditional isotope separator on-line technique, various endeavors have been made on gas catcher cells for converting relativistic RI-beams from in-flight separators to low-energy RI-beams. The origin of the gas catcher is found in the IGISOL (Ion guide isotope separator on-line) technique. Many developments have been made over the years to overcome the various difficulties and drawbacks found in the IGISOL technique

  19. Higher Loop Corrections to the Infrared Evolution of Fermionic Gauge Theories in the RI' Scheme

    DEFF Research Database (Denmark)

    Ryttov, Thomas

    2014-01-01

    We study the evolution of the gauge coupling and the anomalous dimension of the mass towards an infrared fixed point for non-supersymmetric gauge theories in the modified regularization invariant, RI', scheme. This is done at the three loop level where all the renormalization group functions have...

  20. 76 FR 15246 - Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI

    Science.gov (United States)

    2011-03-21

    ...-AA01 Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI AGENCY: Coast Guard, DHS... Rhode Island Sound south of Brenton Point, Rhode Island, for use by vessels waiting to enter... Sound that under current informal practice is routinely used by mariners as an anchorage while waiting...

  1. Kuidas käib kultuuri suurandmete äri maailmas? / Indrek Ibrus

    Index Scriptorium Estoniae

    Ibrus, Indrek

    2016-01-01

    Septembri lõpus Eestis toimuvast konverentsist "Culture 4D: Digitisation, Data, Disruptions, Diversity", mille korraldavad Euroopa Nõukogu, kultuuriministeerium ja Tallinna Ülikool. Konverentsi tähelepanu keskmes on kultuurivaldkonna suurandmete majandamine, suurandmete äri, andmete kasutamine üldiseks hüvanguks ning kultuuri digiteerimisega kaasnevad väljakutsed

  2. Measuring and Monitoring in the South African "Kha Ri Gude" Mass Literacy Campaign

    Science.gov (United States)

    McKay, Veronica

    2015-01-01

    After many previous failed attempts to reach illiterate adults, the award-winning South African "Kha Ri Gude" mass literacy campaign, launched in 2008, undertook to ensure that learners seized the opportunity to learn--for many adults, this was a "last chance". Written from an insider perspective by the campaign's founding…

  3. Molecular cloning and restriction analysis of EcoRI-fragments of Vicia faba rDNA

    International Nuclear Information System (INIS)

    Yakura, Kimitaka; Tanifuji, Shigeyuki.

    1983-01-01

    EcoRI-fragments of Vicia faba rDNA were cloned in plasmid pBR325. Southern blot hybridization of BamHI-digests of these cloned plasmids and Vicia genomic DNA led to the determination of relative positions of BamHI sites in the rDNA and the physical map that had been tentatively made is corrected. (author)

  4. 10 aastat - 30 ettevõtet : KPMG kogemus tasakaalus tulemuskaardiga / Jüri Sakkeus

    Index Scriptorium Estoniae

    Sakkeus, Jüri

    2008-01-01

    Tasakaalus tulemuskaardi koostamise ja rakendamise nõuded, selle plussid ja miinused ning mõju ettevõtte arengule. Vt. samas: Tarmo Noop. Loon süsteemi, mis töötab ise; Kaido Kangur. Kas teate, millal teie äri kokku kukub?; Marko Rillo. Tasakaalus tulemuskaardi sobivusest ja mittesobivusest. Skeemid

  5. 77 FR 7025 - Safety Zones; America's Cup World Series, East Passage, Narragansett Bay, RI

    Science.gov (United States)

    2012-02-10

    ...-AA00 Safety Zones; America's Cup World Series, East Passage, Narragansett Bay, RI AGENCY: Coast Guard... the America's Cup World Series sailing vessel racing event. This safety zone is intended to safeguard...'s Cup-class races on the waters of the East Passage, Narragansett Bay, Rhode Island. Vessels will be...

  6. Eesti kirjandus suure ilma äärel / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1999-01-01

    Eesti kirjanduse esindatusest teatmeteoses "Encyclopedia of world literature in the 20th century" (St. James Press, 1999) ja "Der Literatur Brockhaus" (München... [jt.] : B. I. Taschenbuchverlag, 1995). Ilmunud ka kogumikus: Talvet, Jüri. Ameerika märkmed, ehk, Kaemusi Eestist. Tartu : Ilmamaa, 2000, lk. 121-124

  7. Tüüri "Magma" kuuplaat. Pärt Saksa romaani kangelasena

    Index Scriptorium Estoniae

    2007-01-01

    Erkki-Sven Tüüri heliplaat "Magma" oli kuuplaat nii BBC Music Magazine'is kui ka Gramophone'is. Saksa kirjanik Adam Thorpe avaldas romaani "Taktverschiebung" ("Taktimuutus"), mille peategelast, inglise heliloojat Jack Middletoni iseloomustatakse Arvo Pärdi suure austajana

  8. Dolores Hoffmann pani Türi kiriku aknad särama / Marge Laagemann

    Index Scriptorium Estoniae

    Laagemann, Marge

    2005-01-01

    vitraažikunstnik räägib Türi kiriku vitraažidest, oma teekonnast vitraažide juurde, vitraažide valmistamisest, nende tekkest, ajaloost ning mõjust. Järgneb 2005. 9. dets., lk. 9, 16. dets., lk. 7, 23. dets., lk. 11 ja 30. dets., lk. 7

  9. Itaalias vangistati peaprokuröri tappa tahtnud mafioosod / Ülle Toode

    Index Scriptorium Estoniae

    Toode, Ülle, 1969-

    2005-01-01

    Sitsiilias vahistati ligi poolsada maffiaorganisatsiooni Cosa Nostra väidetavat liiget. Politseini oli jõudnud info, et mafioosod kavatsevad lähiajal tappa Palermo peaprokuröri Pietro Grasso, tabamata on Cosa Nostra juht. Lisa: Kohtunik üksi sõjas maffia vastu

  10. ri Uluots jõudis võõrsilt koju / Rein Hanson

    Index Scriptorium Estoniae

    Hanson, Rein, 1948-

    2008-01-01

    Endise Eesti peaministri ja peaministri presidendi ametis Jüri Uluotsa ja tema abikaasa ning poja säilmed maeti 31. augustil 2008 Kirbla kalmistule. Ümbermatmise tseremoonial esines kõnega ka president Toomas Hendrik Ilves. Vt. samas foto: Koguduse juhatuse esimees vallavanem Anu-Lii Jürman tervitab Kirbla kiriku trepil Eesti Vabariigi presidenti Toomas Hendrik Ilvest

  11. Nõukogu kinnitas Türi kolledži õppetöö kolimise Tartusse

    Index Scriptorium Estoniae

    2010-01-01

    Novembrikuu istungil otsustas TÜ nõukogu Türi kolledžis oleva keskkonnakorralduse ja planeerimise õppekava liita Tartus loodus- ja tehnoloogiateaduskonna (LOTE) juurde. TÜ peahoone ees protestisid selle kava vastu kolledži üliõpilased

  12. Uudised : Tüüri Viiulikontsert Taanis. Lepo Sumera filmimuusika CD. Eesti muusikaauhinnad 2000

    Index Scriptorium Estoniae

    2001-01-01

    E.-S. Tüüri Viiulikontserdi Taani esiettekandest Kopenhaagenis. 2. märtsil esitleti Kinomajas L. Sumera filmimuusika plaati. 3. märtsil andis Eesti Fonogrammitootjate Ühing klubis Decolte üle 2000. a. eesti muusikaauhinnad

  13. Verbascum kurdistanicum (Scrophulariaceae, a new species from Hakkâri, Turkey

    Directory of Open Access Journals (Sweden)

    Mehmet Fırat

    2015-07-01

    Full Text Available Verbascum kurdistanicum Fırat (Scrophulariaceae, is described and illustrated as a new species that is located in Hakkâri, Turkey. In this study, diagnostic morphological characters of this and closely related species (V. oreophilum K.Koch and V. pyramidatum M. Bieb are discussed. Furthermore, distribution maps for the three taxa are provided.

  14. Verbascumkurdistanicum (Scrophulariaceae), a new species from Hakkâri, Turkey.

    Science.gov (United States)

    Fırat, Mehmet

    2015-01-01

    Verbascumkurdistanicum Fırat (Scrophulariaceae), is described and illustrated as a new species that is located in Hakkâri, Turkey. In this study, diagnostic morphological characters of this and closely related species (Verbascumoreophilum K.Koch and Verbascumpyramidatum M. Bieb) are discussed. Furthermore, distribution maps for the three taxa are provided.

  15. ri Pihl vstretilsja s Alfredom Perezom Rubalkaba / Kristina Kareva

    Index Scriptorium Estoniae

    Kareva, Kristina

    2008-01-01

    Siseminister Jüri Pihl kohtus Madridis Hispaania siseministri Alfredo Pérez Rubalcabaþga, et arutada politseiasutuste vahelist koostööd, küberkuritegevuse vastast võitlust ja Hispaania eesistumist Euroopa Liidus 2010. aastal

  16. Tagakiusamine ja kirjutamiskunst / Leo Strauss ; järelsõna Jüri Lipping

    Index Scriptorium Estoniae

    Strauss, Leo, 1899-1973

    2000-01-01

    Ajalooliste tekstide ridade vahele peidetud sõnumi lugemisest. Tsensuuri mõjust filosoofilistele tekstidele. Peidetud sõnumi lugemisest lähtuvast erinevusest eelmoodsate ja uusaegsete filosoofide teostes. Jüri Lipping'u järelsõna Leo Straussi filosoofilistest vaadetest.

  17. Sadamasse lubatud veepargi asemele kerkivad hoopis äri- ja büroohooned / Urmas Seaver

    Index Scriptorium Estoniae

    Seaver, Urmas, 1973-

    2008-01-01

    Salto Arhitektuuribüroo ja Urmas Lõokese Arhitektuuribüroo nägemus Tallinnas Admiraliteedi basseini ääres olevast Ahtri 3 kinnistust, kuhu tuleb kaks õhust kulgevate sildadega ühendatud äri- ja büroohoonet. Kommenteerivad Karli Luik ja Endrik Mänd

  18. The role of the observational approach in RI planning: WAG 5 case study

    International Nuclear Information System (INIS)

    Brill, A.K.; Kuhaida, A.J. Jr.

    1992-10-01

    A Remedial Investigation (RI) Plan was developed for the Oak Ridge National Laboratory (ORNL) Waste Area Grouping (WAG) 5 in March 1988 and submitted to the Environmental Protection Agency (EPA) Region IV and the State of Tennessee for review and approval. The observational approach was evaluated by the ORNL Environmental Restoration (ER) Program and accepted by EPA as an accelerated and cost-effective approach to the RI/Feasibility Study (FS) process for remediation of WAG 5. The traditional approach used in preparing the 1988 RI Plan focused on data completeness, included a typical range of RI data-gathering activities for determining the nature and extent of contamination at WAG 5, and used multiple iterations of sampling activities to deal with uncertainties without consideration of potential deviations. In fall 1991, a revised Field Sampling Plan (FSP) was developed that used the observational approach to integrate site characterization with site remediation needs. This approach recognized the uncertainties of site characterization/remedial planning and developed contingency plans for dealing with them. The observational approach emphasizes data sufficiency to support remedial planning decisions for WAG 5

  19. Tulevane linnapea kavandab kainestusmaja ja Kalevipoega / Jüri Ratas ; interv. Urmas Seaver

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2005-01-01

    Ilmunud ka: Postimees : na russkom jazõke 14. nov., lk 6. Tõenäoline Tallinna linnapea kandidaat vastab küsimustele, mis puudutavad uue linnavalitsuse esimest istungit, pealinna 2006. aasta eelarvet ning Keskerakonna valimislubadusi linna valitsemisel. Lisa: Jüri Ratas

  20. Kas Orase Shelley või Shelley Oras? / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1999-01-01

    Arvustus: Shelley, Percy Bysshe. Valik lüürikat / tlk. Ants Oras; toim. Anne Lange. Tln. : Hortus Litterarum, 1998. Ants Orase ja Minni Nurme tõlgete võrdlus (P. B. Shelley. Luuletusi. Tln., 1960). Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 408-416

  1. Jukose kriis toob äikesepilved vaguniäri kohale / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2004-01-01

    Russian Estonian Rail Services AS - kõige konkurentsivõimelisem transpordi-, side- ja logistikaettevõtete hulgas, Hansapanga kõrgepalgalise eksportööri eriauhinna laureaat. Lisa: Russian Estonian Rail Services 2003. Kommenteerib Indrek Neivelt. Tabel: Transpordi-, side- ja logistikaettevõtted

  2. 21 ideed, millest võiks saada monument või skulptuur / Jüri Saar

    Index Scriptorium Estoniae

    Saar, Jüri, 1973-

    2008-01-01

    Tartu linnavalitsus kogus kokku 21 skulptuuride, monumentide ja mälestustahvlite ideed, et esile tõsta auväärseid kaaslinlasi ning ehitisi. Valmis dokument "Tartu linna monumentide ja skulptuuride rajamise kava aastateks 2008-2013". Kommenteerivad Tiit Kaunissaare ja Jüri Sasi

  3. ANALISIS FAKTOR-FAKTOR YANG MEMENGARUHI TRANSFORMASI KAPABILITAS ORGANISASI DAN PERAN BADAN PEMERIKSA KEUANGAN RI

    Directory of Open Access Journals (Sweden)

    Agus Joko Pramono

    2017-01-01

    Full Text Available ABSTRACT This study is aimed to study the influencing factors of the Audit Board of Republic Indonesia’s roles and capabilities transformation to meet the national development goals. This study use a qualitative approach with Analytic Network Process (ANP method, to map out the interrelated factors of nodes within 3 clusters, which are the external, internal, and supporting factors. Focus Group Discussion (FGD was conducted to design a Framework Analysis. The participants of the FGD were BPK RI officials and its stakeholders including relevant external experts. The FGD has made a quantification framework as an ideal approach to use for data processing on software superdecisions. This process has brought about the priorities as follows: external stakeholder engagement, leadership and governance system, communication and the management of information system. The research has found out that the most significant and urgent factor is the concern of, and support from, the external stakeholders for BPK RI. Therefore, BPK RI has to design a strategy and communication program that can effectively improve the external support and concern. Keywords: Transformation, organizational capability, organizational roles, The Audit  Board of Indonesia, Analytic Network Process. ABSTRAK Kajian ini bertujuan untuk mengkaji faktor-faktor yang berpengaruh terhadap transformasi kapabilitas dan peran Badan Pemeriksa Keuangan Republik Indonesia. Kajian ini menggunakan pendekatan kualitatif dengan metode Analytic Network Process (ANP untuk mendapatkan hubungan antar node dalam 3 cluster (faktor eksternal, internal dan penunjang yang bersifat network. Framework analysis disusun melalui FGD para pakar dari eksternal dan internal BPK RI. Kuantifikasi framework dihasilkan dari FGD para pakar internal BPK RI. Olah data pada software superdecisions menghasilkan prioritas-prioritas sebagai berikut: faktor eksternal prioritasnya Stakeholders Engagement; faktor internal

  4. Author Index

    Indian Academy of Sciences (India)

    user1

    Astr. (2012) 33, 419–420. Author Index. 419. AGGARWAL SUNNY. Photoionization Cross-Section of Chlorine-like Iron, 291. AMBASTHA ASHOK see Das, A. C., 1. ARAKIDA HIDEYOSHI. Effect of Inhomogeneity of the Universe on a Gravitationally. Bound Local System: A No-Go Result for Explaining the Secular Increase in.

  5. AUTHOR INDEX

    Indian Academy of Sciences (India)

    automorphic solutions to fractional order abstract integro-differential equations. 323. Afrouzi G A see Ala Samira ... 521. Agarwal Praveen. Certain fractional integral operators and the generalized multi-index Mittag- ... of positive solutions for sys- tems of second order multi-point bound- ary value problems on time scales 353.

  6. The Ri chicken breed and livelihoods in North Vietnam: characterization and prospects

    Directory of Open Access Journals (Sweden)

    Pascal Leroy

    2011-06-01

    Full Text Available For the last twenty years, the consumption of poultry meat has boomed in Vietnam as in the rest of the developing world. Capital-intensive production has grown rapidly to satisfy this demand. Based on a few numbers of genetically uniform strains, these systems threaten biodiversity. In Vietnam, both rural and urban households still keep indigenous chickens as part of a diversified livelihood portfolio. In line with the national in situ conservation strategy, this study approached the context of local poultry keeping in two rural and one suburban districts of Northern Vietnam. It aimed at understanding households’ willingness, constraints and opportunities for practice improvement, including breeds’ management. As the Ri chicken constitutes the large majority of backyard flocks, two particular objectives of this study are the morpho-biometric characterisation of phenotypic diversity among individuals classified as Ri by farmers and an assessment of their productive potential. Chicken was found to hold a different place in livelihoods of the three districts with consequences on the management of genetic resources. The most favourable conditions for improvement of the Ri breed was found in the rural district of Luong-Son, due to market integration. In the more remote district of Ky-Son, living standards were lower and much would be gained from Ri conservation. Ri breed was the most threatened in the suburban Gia-Lam district, where poultry was a minor side-activity, lacking incentive for genetic management. From motives and constraints, tracks about breeding goals are suggested. Further considerations about conservation, improvement, market integration and livelihoods are proposed.

  7. The Resilient Schools Consortium (RiSC): Linking Climate Literacy, Resilience Thinking and Service Learning

    Science.gov (United States)

    Branco, B. F.; Fano, E.; Adams, J.; Shon, L.; Zimmermann, A.; Sioux, H.; Gillis, A.

    2017-12-01

    Public schools and youth voices are largely absent from climate resilience planning and projects in New York City. Additionally, research shows that U.S. science teachers' understanding of climate science is lacking, hence there is not only an urgent need to train and support teachers on both the science and pedagogy of climate change, but to link climate literacy, resilience thinking and service learning in K-12 education. However, research on participation of students and teachers in authentic, civic-oriented experiences points to increased engagement and learning outcomes in science. The Resilient Schools Consortium (RiSC) Project will address all these needs through an afterschool program in six coastal Brooklyn schools that engages teachers and urban youth (grades 6-12), in school and community climate resilience assessment and project design. The RiSC climate curriculum, co-designed by New York City school teachers with Brooklyn College, the National Wildlife Federation, New York Sea Grant and the Science and Resilience Institute at Jamaica Bay, will begin by helping students to understand the difference between climate and weather. The curriculum makes extensive use of existing resources such as NOAA's Digital Coast and the Coastal Resilience Mapping Portal. Through a series of four modules over two school years, the six RiSC teams will; 1. explore and understand the human-induced drivers of climate change and, particularly, the significant climate and extreme weather related risks to their schools and surrounding communities; 2. complete a climate vulnerability assessment within the school and the community that is aligned to OneNYC - the city's resilience planning document; 3. design and execute a school-based resilience project; and 4. propose resilience guidelines for NYC Department of Education schools. At the end of each school year, the six RiSC teams will convene a RiSC summit with city officials and resilience practitioners to share ideas and

  8. Etching twin core fiber for the temperature-independent refractive index sensing

    Science.gov (United States)

    Zhang, Chuanbiao; Ning, Tigang; Li, Jing; Zheng, Jingjing; Gao, Xuekai; Lin, Heng; Pei, Li

    2018-04-01

    We proposed an ultra-compact chemically etched twin core fiber (TCF) based optic refractive index (RI) sensor, in which the etched fiber was fabricated by immersing in an aqueous solution of hydrofluoric acid (HF) to etch the cladding. Due to the multipath evolutions of light during the TCF, the mode induced interference pattern can be used for measurement. Numerical simulations were performed, demonstrating that only the cladding mode strongly interacts with the surrounding media, and the higher cladding modes will be more sensitive to external medium. In the experiment demonstration, the RI response characteristics of the sensor were investigated, which shows a relatively high RI sensitivity and a much low temperature cross-sensitivity with about 1.06 × 10-6 RIU °C-1. Due to low cost and easy fabrication, the sensor can be a suitable candidate in the biochemical field.

  9. Refractive index and temperature sensitivity characteristics of a micro-slot fiber Bragg grating.

    Science.gov (United States)

    Saffari, Pouneh; Yan, Zhijun; Zhou, Kaiming; Zhang, Lin

    2012-07-10

    Fabrication and characterization of a UV inscribed fiber Bragg grating (FBG) with a micro-slot liquid core is presented. Femtosecond (fs) laser patterning/chemical etching technique was employed to engrave a micro-slot with dimensions of 5.74 μm(h)×125 μm(w)×1388.72 μm(l) across the whole grating. The device has been evaluated for refractive index (RI) and temperature sensitivities and exhibited distinctive thermal response and RI sensitivity beyond the detection limit of reported fiber gratings. This structure has not just been RI sensitive, but also maintained the robustness comparing with the bare core FBGs and long-period gratings with the partial cladding etched off.

  10. Refractive index sensing based on higher-order mode reflection of a microfiber Bragg grating.

    Science.gov (United States)

    Zhang, Yu; Lin, Bo; Tjin, Swee Chuan; Zhang, Han; Wang, Guanghui; Shum, Ping; Zhang, Xinliang

    2010-12-06

    A fiber Bragg grating written in a photosensitive microfiber using KrF excimer laser via a uniform phase mask is demonstrated. We have successfully fabricated two Bragg gratings in microfibers having different diameters. In the reflection spectrum of a microfiber Bragg grating (MFBG), we observed two reflection peaks,which agrees with our numerical simulation results. Compared with the fundamental mode reflection, the higher-order reflection mode is more sensitive to the refractive index (RI) variation of the surrounding fluid due to its larger evanescent field. The measured maximum sensitivity is ~102 nm/RIU (RI unit) at an RI value of 1.378 in an MFBG with a diameter of 6 μm.

  11. Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance.

    Science.gov (United States)

    Warhurst, David C; Craig, John C; Raheem, K Saki

    2016-01-01

    Antimalarial chloroquine (CQ) prevents haematin detoxication when CQ-base concentrates in the acidic digestive vacuole through protonation of its p-aminopyridine (pAP) basic aromatic nitrogen and sidechain diethyl-N. CQ export through the variant vacuolar membrane export channel, PFCRT, causes CQ-resistance in Plasmodium falciparum but 3-methyl CQ (sontochin SC), des-ethyl amodiaquine (DAQ) and bis 4-aminoquinoline piperaquine (PQ) are still active. This is determined by changes in drug accumulation ratios in parasite lipid (LAR) and in vacuolar water (VAR). Higher LAR may facilitate drug binding to and blocking PFCRT and also aid haematin in lipid to bind drug. LAR for CQ is only 8.3; VAR is 143,482. More hydrophobic SC has LAR 143; VAR remains 68,523. Similarly DAQ with a phenol substituent has LAR of 40.8, with VAR 89,366. In PQ, basicity of each pAP is reduced by distal piperazine N, allowing very high LAR of 973,492, retaining VAR of 104,378. In another bis quinoline, dichlorquinazine (DCQ), also active but clinically unsatisfactory, each pAP retains basicity, being insulated by a 2-carbon chain from a proximal nitrogen of the single linking piperazine. While LAR of 15,488 is still high, the lowest estimate of VAR approaches 4.9 million. DCQ may be expected to be very highly lysosomotropic and therefore potentially hepatotoxic. In 11 pAP antimalarials a quadratic relationship between logLAR and logResistance Index (RI) was confirmed, while log (LAR/VAR) vs logRI for 12 was linear. Both might be used to predict the utility of structural modifications.

  12. Afghanistan Index

    DEFF Research Database (Denmark)

    Linnet, Poul Martin

    2007-01-01

    basis. The data are divided into different indicators such as security, polls, drug, social, economic, refugees etc. This represents a practical division and does not indicate that a picture as to for instance security can be obtained by solely looking at the data under security. In order to obtain...... a more valid picture on security this must incorporate an integrated look on all data meaning that for instance the economic data provides an element as to the whole picture of security.......The Afghanistan index is a compilation of quantitative and qualitative data on the reconstruction and security effort in Afghanistan. The index aims at providing data for benchmarking of the international performance and thus provides the reader with a quick possibility to retrieve valid...

  13. Micro-structured optical fiber sensor for simultaneous measurement of temperature and refractive index

    Science.gov (United States)

    Liu, Ying-gang; Liu, Xin; Ma, Cheng-ju; Zhou, Yu-min

    2018-03-01

    Through using micro-machining method for optical fiber sensor, a kind of miniature, compact and composite structural all-fiber sensor is presented. Based on manufacturing two micro-holes with certain distance in ordinary single-mode fiber Bragg grating (FBG) by excimer laser processing technique, we fabricate a dual Fabry-Perot-FBG (FP-FBG) composite fiber interferometric sensor, which can be used in simultaneous measurement for liquid's refractive index (RI) and temperature change. Due to every micro-hole and the dual micro-holes in fiber acting as different Fabry-Perot (FP) cavities, this kind of sensor has not only different RI sensitivities but also different temperature sensitivities, which are corresponding to the wavelength shifts of the fine interference fringes and spectral envelope, respectively. The experimental results show that the spectral wavelength shift keep better linear response for temperature and RI change, so that we can select the higher temperature and RI sensitivities as well as the analyzed sensitivities of FBG to utilize them for constituting a sensitivity coefficients matrix. Finally, the variations of liquid's temperature and RI are detected effectively, and the resolutions can reach to 0.1 °C and 1.0 ×10-5 RIU. These characteristics are what other single-type sensors don't have, so that this kind of all-fiber dual FP-FBG composite fiber interferometric sensor can be used in extremely tiny liquid environment for measuring different physical quantities simultaneously.

  14. An iterative correction approach used to retrieve the refractive index of squid pigment aerosols

    Science.gov (United States)

    Dinneen, Sean R.; Deravi, Leila F.; Greenslade, Margaret E.

    2018-03-01

    Pigments localized within cephalopod chromatophores are important for dermal coloration. When isolated and used as materials outside of the animal, the pigments can be processed as aerosols, illustrating a potential application for spray-on-coatings. The optical features of the pigment aerosols are difficult to analyze and require a method to correct for the particle charging and solvent effects accumulated during the aerosolizing process. We describe a method to account for these effects using an innovative iterative approach tied to retrieved refractive index (RI) values. RI retrievals were obtained via the best fit between the corrected, experimentally observed extinction efficiencies compared to those calculated by Mie theory for a specific RI at selected sizes. In addition to these retrievals, the impact of solvent on the particles’ optical properties was also examined via the Maxwell-Garnett mixing rule. Ultimately, we obtained a pigment RI with a real portion (n) of 1.66 (±0.05) representing a lower limit and an imaginary portion (k) of 0.13 (±0.08)i representing an upper limit for the generated aerosols. Combined, this approach advances techniques used to retrieve RI values that benefits both atmospheric chemistry and bio-inspired materials.

  15. Demystifying back scatter interferometry: a sensitive refractive index detector

    DEFF Research Database (Denmark)

    Jepsen, Søren Terpager; Jørgensen, Thomas Martini; Trydal, Torleif

    2014-01-01

    BACKGROUND: Back Scatter Interferometry (BSI) is a sensitive method for detecting changes of the refractive index (RI) in small capillaries. The method was originally developed as an off-axial column detector for use in Liquid Chromatography or Capillary Electrophoresis systems, but it has been...... acting like a common-path interferometer. METHODS: A HeNe laser is directed at a glass capillary with inner diameter of 1.4 mm and reflected light from air/glass and liquid/glass interfaces interfere to form an RI dependent intensity fringe pattern at a CCD detector. The fringe shift relative...... a common-path interferometer. The sensitivity of the BSI system is given by twice the inner diameter of the capillary times the wavenumber of the light source. Our results suggest that Back Scatter Interferometry does not provide a unique measurement principle for sensing biochemical bindings compared...

  16. Ääremärkused diagnoosiks : Imagosfäär tulgu I = Remarks for diagnosis : Imagosphere Come I / Jüri Soolep

    Index Scriptorium Estoniae

    Soolep, Jüri, 1962-

    2008-01-01

    Imagosfääri empiiriline kehtestumine: meedia, Gutenbergi galaktika, isiklik imagosfäär. Imagosfääri teoreetiline konstitutsioon: simulaakrumid ja hüperreaalsus. Imagosfääri praktiline realisatsioon: Putini Venemaa. Artikkel põhineb Eesti Kunstiakadeemias 2007. a. sügissemestril peetud loengukursusel "Linnaehituse nüüdisaegsed probleemid". Bibliograafia lk. 38

  17. Improving the efficiency of copper indium gallium (Di-selenide (CIGS solar cells through integration of a moth-eye textured resist with a refractive index similar to aluminum doped zinc oxide

    Directory of Open Access Journals (Sweden)

    M. Burghoorn

    2014-12-01

    Full Text Available Textured transparent conductors are widely used in thin-film silicon solar cells. They lower the reflectivity at interfaces between different layers in the cell and/or cause an increase in the path length of photons in the Si absorber layer, which both result in an increase in the number of absorbed photons and, consequently, an increase in short-circuit current density (Jsc and cell efficiency. Through optical simulations, we recently obtained strong indications that texturing of the transparent conductor in copper indium gallium (di-selenide (CIGS solar cells is also optically advantageous. Here, we experimentally demonstrate that the Jsc and efficiency of CIGS solar cells with an absorber layer thickness (dCIGS of 0.85 μm, 1.00 μm and 2.00 μm increase through application of a moth-eye textured resist with a refractive index that is sufficiently similar to AZO (nresist = 1.792 vs. nAZO = 1.913 at 633 nm to avoid large optical losses at the resist-AZO interface. On average, Jsc increases by 7.2%, which matches the average reduction in reflection of 7.0%. The average relative increase in efficiency is slightly lower (6.0%. No trend towards a larger relative increase in Jsc with decreasing dCIGS was observed. Ergo, the increase in Jsc can be fully explained by the reduction in reflection, and we did not observe any increase in Jsc based on an increased photon path length.

  18. Preoperative tumor localization of primary hyperparathyroidism. Comprehensive study of ultrasonography (US), scintigraphy (RI), arteriography (AG) and venous sampling (VS)

    Energy Technology Data Exchange (ETDEWEB)

    Morita, Yutaka; Shinohara, Masahiro; Ito, Kazuo; Imamura, Fumimoto; Kasai, Yoichi (Hokkaido Univ., Sapporo (Japan). School of Medicine); Ishizuka, Reiki

    1983-02-01

    The diagnostic rate of each methods were discussed in thirty six cases and the following conclusions were made. (1.) The diagnostic rate of US, RI, AG and VS was 64.7%, 50%, 57.9%, 60.7% respectively. (2.) Ultrasonography and subtruction-scintigraphy were useful for screening examination for localization of parathyroid tumor. (3.) The reasonable diagnostic procedures were as follows: (1) In the cases of palpable, reno-uretrolithiasic type, and biochemical type: US ..-->.. RI ..-->.. VS. (2) In the cases of nonpalpable osteolytic type, and previous neck surgery: US ..-->.. RI ..-->.. AG ..-->.. VS. These results indicate that the systemic diagnoses are useful to predict localization of parathyroid tumors.

  19. A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

    DEFF Research Database (Denmark)

    Jensen, Bettina Margrethe; Dissing, S; Skov, P S

    2005-01-01

    Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation......, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology....

  20. Change in refractive index of muscle tissue during laser-induced interstitial thermotherapy.

    Science.gov (United States)

    Chen, Na; Chen, Meimei; Liu, Shupeng; Guo, Qiang; Chen, Zhenyi; Wang, Tingyun

    2014-01-01

    This paper presents a long-period fiber-grating (LPG) based Michelson interferometric refractometry to monitor the change in refractive index of porcine muscle during laser-induced interstitial thermotherapy (LITT). As the wavelength of RI interferometer alters with the change in refractive index around the probe, the LPG based refractometry is combined with LITT system to measure the change in refractive index of porcine muscle when irradiated by laser. The experimental results show the denaturation of tissue alters the refractive index significantly and the LPG sensor can be applied to monitor the tissue state during the LITT.

  1. EDF'S ''OMF-structures'' RI-ISI process: overview of the methodology, applications and comparison with the other existing RI-ISI initiatives

    International Nuclear Information System (INIS)

    Codron, P.; Lauriot, B.; Dubreuil-Chambardel, A.

    2001-01-01

    The OMF-Structures process has been developed by EDF in order to optimise the maintenance of piping components. The principles of the OMF-Structures are consistent with the RCM concepts in EDF's OMF process (applied to active components). Several applications of this process have been performed. This paper also presents several applications which have been performed, notably on the AFW, RHR, and HPSI/LPSI systems of EDF's 900 MW PWR plants. These applications led to propose optimised preventive maintenance programs for these systems. These updated preventive maintenance programs confirmed and justified a large proportion of existing maintenance, despite some inspection tasks were suppressed and some inspection tasks were added. Globally, these new programs guarantee a better safety level, insuring that preventive maintenance is applied on piping segments where risks are concentrated. A comparative evaluation of the OMF-Structures process with the EPRI and WOG/ASME RI-ISI methodologies has been performed. This comparison demonstrated the consistence of the OMF-Structures principles and selection criteria with the other RI-ISI processes. (author)

  2. Intravenous flurbiprofen axetil can stabilize the hemodynamic instability due to mesenteric traction syndrome--evaluation with continuous measurement of the systemic vascular resistance index using a FloTrac® sensor.

    Science.gov (United States)

    Takada, Motoshi; Taruishi, Chieko; Sudani, Tomoko; Suzuki, Akira; Iida, Hiroki

    2013-08-01

    Evaluation of the stabilizing effect of intravenous flurbiprofen axetil against hemodynamic instability due to mesenteric traction syndrome (MTS) by continuous measurement of systemic vascular resistance index (SVRI) using a FloTrac(®) sensor was evaluated. Prospective randomized trial. A single-center study performed in an educational hospital. Two prospective studies were carried out, each with 40 patients scheduled for elective open abdominal surgery. Twenty patients received 50 mg of flurbiprofen axetil after the recognition of MTS by the anesthesiologist (group FT). The remaining patients served as controls (groups CP and CT). SVRI data was collected every 20 seconds for 1 hour after starting the laparotomy. The average SVRI prior to skin incision was taken as the baseline. Following 3 values were devised to evaluate MTS: the S-value (sum total of changes in SVRI from baseline), the T-value (period during which SVRI remained 20% or more below baseline), and the M-value (maximum change in SVRI from baseline). In group FP, decrease in SVRI was smaller than in group CP, and statistical differences in the 3 values were found. In group FT, SVRI recovered earlier than in group CT, and statistical differences were found in S-value and T-value. However, the M-value had no statistical differences. Intravenous flurbiprofen axetil can stabilize the hemodynamic instability due to MTS. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Short rest interval lengths between sets optimally enhance body composition and performance with 8 weeks of strength resistance training in older men.

    Science.gov (United States)

    Villanueva, Matthew G; Lane, Christianne Joy; Schroeder, E Todd

    2015-02-01

    To determine if 8 weeks of periodized strength resistance training (RT) utilizing relatively short rest interval lengths (RI) in between sets (SS) would induce greater improvements in body composition and muscular performance, compared to the same RT program utilizing extended RI (SL). 22 male volunteers (SS: n = 11, 65.6 ± 3.4 years; SL: n = 11, 70.3 ± 4.9 years) were assigned to one of two strength RT groups, following 4 weeks of periodized hypertrophic RT (PHRT): strength RT with 60-s RI (SS) or strength RT with 4-min RI (SL). Prior to randomization, all 22 study participants trained 3 days/week, for 4 weeks, targeting hypertrophy; from week 4 to week 12, SS and SL followed the same periodized strength RT program for 8 weeks, with RI the only difference in their RT prescription. Following PHRT, all study participants experienced increases in lean body mass (LBM) (p body strength (p body fat (p high-intensity strength RT with shortened RI induces significantly greater enhancements in body composition, muscular performance, and functional performance, compared to the same RT prescription with extended RI, in older men. Applied professionals may optimize certain RT-induced adaptations, by incorporating shortened RI.

  4. RiSA: A Science Festival for the Bilingual and Bicultural Rio Grande Valley

    Science.gov (United States)

    Key, Joey Shapiro; Torres, Cristina; Stone, Robert

    2014-03-01

    The Rio Grande Science and Arts (RiSA) Festival organized by the Center for Gravitational Wave Astronomy (CGWA) at the University of Texas at Brownsville (UTB) will use a wide variety of artforms to bring physics and science topics to the bilingual and bicultural population of the Rio Grande Valley of South Texas. The science and art faculty at UTB will partner with art and education professionals to create an annual community event celebrating science though art. Music, dance, poetry, and visual arts will headline the festival activities. Festival events and products will be produced in both English and Spanish to attract and inform the bilingual local community. The RiSA Festival is supported by the Science Festival Alliance and the Sloan Foundation. Supported by the Science Festival Alliance and the Sloan Foundation.

  5. Browse Title Index

    African Journals Online (AJOL)

    Items 401 - 450 of 473 ... Vol 6, No 1 (2003), The Effect of Animal and Plant Protein-Based Diets on the Crude Protein Requirement of Cockerel Starters, Abstract. RI Salami, SOO Oyewole, AA Odunsi, IO Ogunlade. Vol 4, No 2 (2001), The effect of calcium and phosphorus supplementation on the composition of milk and blood ...

  6. Browse Title Index

    African Journals Online (AJOL)

    Items 101 - 150 of 272 ... Vol 7, No 2 (2008), Haematology of dogs infected with canine distemper virus, Abstract PDF. MCO Ezeibe, RI Udegbunam. Vol 15, No 3 (2017), Haemogram and hormonal profile of WAD bucks treated with leaf ethanolic extract of Spondias mombin, Abstract PDF. AA Oloye, OE Ola-Davies, MO ...

  7. Uudised : Eesti muusikalistaarid Euroopas. Tüüri 5.sümfoonia Tallinnas

    Index Scriptorium Estoniae

    2005-01-01

    Koit Toome, Ele Millistver ja Lauri Liiv alustavad 1. detsembril Brnos rahvusvahelises muusikalitrupis "Hairi" proovidega. Esietendus on 26. dets. Iserlohni linnas Saksamaal ning etendusi antakse järgmise aasta 16. aprillini Saksa linnades, Austrias, Šveitsis ja Taanis. Erkki-Sven Tüüri 5. sümfoonia tuleb Eestis esiettekandele 10. dets. Estonia Kontserdisaalis, teose esiettekannet selle aasta veebruaris Stuttgardis dirigeeris Olari Elts

  8. ri viin : aasta jagu pohmellita võidujoovastust / Cathryne Davis ; interv. Neeme Raud

    Index Scriptorium Estoniae

    Davis, Cathryne

    2003-01-01

    Ameerika Ühendriikides müüdavatest Eesti viinadest on kõige suurema edu saavutanud Türi vodka. New-Yorgi suhtekorraldusfirma Deussen Global Comunications'i esindaja Cathryne Davis näeb müügiedu põhjustena viina kõrget kvaliteeti, turundusalast koostööd rahvusvaheliselt tuntud Bacardi'ga, eliidile suunatud sponsorlust, ulatuslikku müügivõrku ja edukat reklaamikampaaniat

  9. Riigikohus arutleb autode üle / Ranno Tingas, Lemmi Kann ; kommenteerinud Jüri Allikalt

    Index Scriptorium Estoniae

    Tingas, Ranno, 1976-

    2009-01-01

    Riigikohtu lahenditest 3-3-1-93-08, 3-3-1-44-00, Tallinna Ringkonnakohtu lahendist 2-3-143/2002 sõiduautode erisoodustuse küsimuses. Kommenteerib Maksukonsultandi UÜ jurist, Eesti Maksumaksjate Liidu (EML) juhatuse liige Jüri Allikalt. Lisa: Maksuamet: sõidupäevikud ei kao kuhugi / Lemmi Kann (ÄP Online, 05.03.2009) ; MTA pressiteade ; EML teabenõue ; MTA vastus

  10. Soome kriminullide tõlkimise võistluse võitis Jüri Valge

    Index Scriptorium Estoniae

    2003-01-01

    Soome kriminaalkirjanduse tõlkevõistluse võitis Jüri Valge, teise koha pälvis Ave Leek, kolmandat kohta jagavad Anne Kütt, Annus Raud ja Meri-Liis Laherand. Tõlgitavateks autoriteks olid Leena Lehtolainen ja Reijo Mäki. Vt. ka Sirp, 2003, 14. nov., lk. 18; Eesti Päevaleht : Arkaadia, 14. nov., lk. 14. Vt. ka Looming, 2003, nr. 11, lk. 1750

  11. RI: Rheology as a Tool for Understanding the Mechanics of Live Ant Aggregations, Part 2

    Science.gov (United States)

    2016-11-04

    earwax of pigs, dogs , cows, and humans. We find that earwax is shear-thinning for all these animals. This ability enables it to cling to the ear in low...self-cleaning.” Society for Integrative and Comparative Biology annual meeting, 2017.  P. Yang, D. Dao, R. Lehner, D. Hu, “ The hydrodynamics of...RI: Rheology as a Tool for Understanding the Mechanics of Live Ant Aggregations, Part 2 An Anton Paarr MCR 501 rheometer was purchased in order to

  12. 3D Scrape-off layer modelling with BoRiS

    International Nuclear Information System (INIS)

    Riemann, J.; Borchardt, M.; Schneider, R.; Mutzke, A.

    2005-01-01

    The 3D fluid transport code BoRiS is applied to a hydrogen plasma and a neutral fluid in a stellarator-like geometry equipped with a poloidal ring limiter. The results demonstrate the capability of dealing with 3D effects which can be related to both the influence of the geometry and the plasma-neutral interaction as well. The setup used has similarities with a poloidal gas target in a fusion device

  13. RiSKi: A Framework for Modeling Cyber Threats to Estimate Risk for Data Breach Insurance

    OpenAIRE

    Panou, Angeliki; Ntantogian, Christoforos; Xenakis, Christos

    2017-01-01

    Historically, the financial benefits of cyber security investments have not been calculated with the same financial discipline used to evaluate other material investments. This was mainly due to a lack of readily available data on cyber incidents impacts and systematic methodology to support the efficacy of cyber investments. In this paper we propose an innovative, cyber investment management framework named RiSKi that incorporates detection and continuous monitoring of insiders societal beha...

  14. XX sajandi hispaania teater : peamärgid / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    1998-01-01

    Hispaania ja ladinaameerika näitekirjandusest. Ka näidendite lavastamisest eesti teatrites. Põhjalikumalt Ram̤n MarÍa del Valle-Incl{u00E1ni (1866-1936), Federico GarcÍa Lorca (1898-1936) ja Antonio Buero Vallejo (sünd. 1916) loomingust. Ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 234-250

  15. Euroopa firmad on asunud oma äri ümber korraldama / Ralph Atkins, Peggy Hollinger

    Index Scriptorium Estoniae

    Atkins, Ralph

    2004-01-01

    Euroopa Liidu juhtide sõnul liigutakse aeglaselt 2000. aastal Lissaboni tippkohtumisel seatud sihtidele viia Euroopa majandus konkurentsivõimelt esikohale maailmas. Euroopa ettevõtted on asunud äri ümberstruktureerima eesmärgiga kärpida kulusid ja leida firmade konkurentsieeliseid. Lisad: Muundumine nagu õpikus; Ümberkorraldamise tulemused siiani teadmata; Erik Aru. Eestis on eduka restruktureerimise näiteks Baltika ja Harju Elekter

  16. Professor Jüri Talvetist sai Ida-Lääne akadeemia liige / intervjueerinud Rein Veidemann

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2011-01-01

    Intervjuu Tartu ülikooli maailmakirjanduse professori Jüri Talvetiga luulefestivalist Curtea de Argeş ("Nopţile de Poezie de la Curtea de Argeş") ja tema rumeenia keelde tõlgitud luulekogust „Unest, lumest” ("De din somn, de din zăpadă" - tõlkija Dumitru M. Ion), mida autor seal esitlemas käis ning Ida-Lääne akadeemiast (Academia Internationala Orient-Occident), mille tegevliikmeks ta valiti

  17. Uudised : Tüüri esiettekanne Frankfurdis. Corelli Musicult "Jõulud mõisas"

    Index Scriptorium Estoniae

    2006-01-01

    22., 23. ja 24. nov. Frankfurdi Alte Operis esiettekandele tulevast Erkki-Sven Tüüri uuest "Klaverikontserdist". Eesti-Tšiili trio Raivo Tafenau - Meelis Vind - Ricardo Padilla kontsertidest sarja "Mõisaromantika" raames 25. nov. Taagepera lossis Valgamaal, 26. nov. Tõstamaa mõisas Pärnumaal ja 16. dets. Vihterpalu mõisas Harjumaal. Hans Neuenfelsi lavastatud Mozarti ooperist "Idemeneo" Deutsche Operis Berliinis. Inglise ansambli Procol Harumi hiti "A Whiter Shade of Pale" autoriõigustest

  18. ri Kasel on väljas kaks suurt näitust : ...

    Index Scriptorium Estoniae

    2005-01-01

    Kuni 6. I 2006 saab Belgias Liege'i kaasaegse kunsti keskuses vaadata Jüri Kase suuri maale, paarisadat joonistust ning objekti ja kuni 12. XII Inglismaal Oxfordi Jacqueline du Pre muusikahoones maale. Liege'i näitusel on väljas ka Jaanus Miku tehtud video "Pinta pilte". 22.-26. XI Eesti kultuuripäevadel Oxfordis esines Weekend Guitar Trio, Kristiina Ehin luges luulet, näidati Priit Tenderi ja Ülo Pikkovi animafilme

  19. Pelaksanaan PP RI No.19/2008 Sebagai Acuan Kinerja Camat pada Aspek Pemerintahan dan Pendidikan

    Directory of Open Access Journals (Sweden)

    Merry Chairina DM. Sinaga

    2015-06-01

    Full Text Available This study aims to determine the performance camat in the governance and education, which refers to PP RI No.19 / 2008. Researchers used descriptive method implemented in the District Percut Sei Tuan. The sample was the whole population is with 37 employees and only have a single variable: the implementation of PP RI No.19 / 2008 as a reference to the performance of district head in the governance and education in the District Percut Sei Tuan, Deli Serdang regency. Data collection techniques by observation through the observation either directly or indirectly to the subject under study. In this study the authors conducted interviews with respondents who considered berkopetensi in this study. The results showed that the performance camat in the governance and education, which refers to PP RI No.19 / 2008 can be categorized as good, such as the active role undertaken whenever a meeting / conference with employees and citizens. Often talked about the problem of improving the quality of work and education, an invitation to attend the big day, receiving the proposal / opinion of the district head in the field of government development issues of education, accepted the proposal of the villagers regarding the development of education, and play an active role in. arrangements regarding the education in collaboration with third parties.

  20. Development of Biochips and Kits using RI Detection Technology for Life Science

    International Nuclear Information System (INIS)

    Park, Sang Hyun; Park, H. J.; Choi, S. M.

    2010-04-01

    Microarrays have recently become a precious research tool for proteomics and clinical investigation. In this study, we report on an efficient strategy for the detection of phosphorylation of a substrate catalyzed by kinase, using the radioisotope (RI) detection technique for a protein biochip. The biochip for the detection of phosphorylation using a RI facilitates the detection of phosphorylation with minimum amount of a sample by simple processes, compared with the conventional method using an antibody. It was more than 30 times detection sensitivity compared to conventional fluorescence detection technique. This technique does not employ the use of the blocking step which is commonly used in conventional methods to prevent non-specific binding. ELSA method was more than seven steps, but the usage of RI detection technique reduces the overall steps. Consequently, this technique is very simple, and considerably reduces the experiment time thus facilitating in an easy detection. Furthermore, it is highly sensitivity, thus facilitating the detection of even minor quantities of protein and rapid data analysis. It can be a useful tool for a high throughput screening in biological and medical research, and for studying protein-protein interactions

  1. Dating the Bibong-ri Neolithic site in Korea: Excavating the oldest ancient boat

    International Nuclear Information System (INIS)

    Park, Gyujun; Kim, Jong-Chan; Youn, Minyoung; Yun, Chongcheol; Kang, Jin; Song, Yong-Mi; Song, Su-Jin; Noh, Hye-Jin; Kim, Do-Kyun; Im, Hack-Jong

    2010-01-01

    The remains of an ancient wooden boat were unearthed at the Bibong-ri shell mound site. The site was located at Bibong-ri, Bugog-myeon, Changnyeong-gun, Gyeongsangnam-do in South Korea. A substantial fragment of the vessel was discovered in the lowest layer of the site. We collected 17 samples of charcoal and wood from pebble, sand, and shell layers. Sample preparation extracted the carbon from each sample material and converted it into graphite for AMS radiocarbon dating. Radiocarbon dates of the samples indicate that they belong to the Neolithic period and that the boat dates from ca. 5700 BC. To this point, the oldest known boat in the world has been a wooden boat dating from ca. 5500 BC in China. Other ancient boats from around the world include a logboat dating from ca. 3600 BC in Japan and a fleet of wooden boats dating from ca. 3000 BC in Egypt. The Bibong-ri boat is the first boat from the Neolithic period ever found in South Korea and must represent one of the world's oldest known boats.

  2. The experiences to improve plant performance and reliability of Ko-Ri nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Ho Weon [Korea Electric Power Corp. Ko-Ri nuclear power division, Ko-Ri (Korea, Republic of)

    1998-07-01

    This paper provides a discussion of the lessons learned from operational experience and the future plans to improve performance of the Ko-Ri plant. To operate nuclear power plants safely with good performance is the only way to mitigate the negative image of nuclear power generation to the public and to enhance the economical benefit compared to other electrical generation method. Therefore, in a continuous effort to overcome a negative challenge from outside, we have driven an aggressive 'OCTF' campaign as part of safety. As a result of our efforts, the following remarkable achievements have been accomplished. (1) 3 times of OCTF during recent three years (2) Selected twice as a top notch power plant on the list of NEI magazine in terms of plant capacity factor (3) No scram recorded in 1997 for all 4 units at Ko-Ri site. Ko-Ri is now undergoing the large scale plant betterment projects for retaking-off our operating performance to the level of new challenge target. Such improvement of critical components in the reactor coolant system and turbine system greatly contribute to increase the safety and reliability of the plant and to shortening of the planned outage period as well as to reduction of radiation exposure and radwaste. (Cho, G. S.). 5 tabs., 10 figs.

  3. RI cisternography and CT cisternography in chronic subdural effusion in infancy

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, K.; Hayakawa, I. (Bokuto Municipal Hospital of Metropolitan, Tokyo (Japan))

    1980-10-01

    Differential diagnosis has been made more accurately between subdural and subarachnoid effusions in infancy since the introduction of the CT scan. We have four cases where In-DTPA (lmCi) and Metrizamide (5 ml x 170 mgl/dl) were given intrathecally at the same time. These dynamics were followed at intervals of 3, 6, 24, and 48 hours, and the diagnosis of chronic subdural effusion (or hematoma) was made at the time of surgery. The findings of both cisternographies were analyzed in these 4 cases. The dynamics of the two materials in the CSF space were almost the same. Comparing the two materials, CT cisternography delineates the anatomical structures of CSF pathways more clearly and accurately. Cerebral sulci and sylvian fissures were well defined with metrizamide at 3 and/or 6 h, but the subdural space was nonfilling. The diagnosis of the CSF block is significant in determining operative indications. RI cisternography seems to be the better method of detecting abnormal findings regarding convexity flow, especially the asymmetry of cerebral convexity. However, the asymmetrical convexity flow as determining by RI at 24 and/or 48 h corresponds quite closely to asymmetrical sylvian-fissure filling by metrizamide at 3 and/or 6 h. It has been concluded that metrizamide CT cisternography can replace some parts of RI cisternography in studying chronic subdural effusion in infancy.

  4. Quantitative and clinical evaluation of whole CSF-axis RI image

    International Nuclear Information System (INIS)

    Tomono, Yuji; Nose, Tadao; Maki, Yutaka

    1987-01-01

    Whole CSF-axis RI scintigraphy was evaluated in 122 adult patients intending to know not only intracranial CSF flow but also the dynamics of whole CSF axis, particularly of spinal CSF flow. The change of radioactivity in several compartments was studied quantitatively with a dataprocessor on 18 cases with dilated ventricles, and more practically, clinical features and the findings of the films were comparatively studied on all the cases. The results were as follows: (1) Roughly speaking, the findings were classified into two types, i.e. a type with early RI movement to the intracranial CSF space and another with stagnation of radioactivity in spinal space till late stage, even 48 hours after RI injection (spinal stasis). (2) Although majority of the cases with spinal stasis did not show ventricular stasis, a shunt operation was not effective even when ventricular stasis was observed. (3) Spinal stasis tended to increase with aging, and was observed more frequently in cases with possible severe cerebral damage, as severe cerebrovascular disease and severe deterioration of mental activity. (4) The clearance of radioactivity of whole CSF-axis was remarkably delayed. It is considered that the spinal CSF flow is generated by intracranial CSF pulsation and, so, that spinal stasis shows the condition of lowered CSF flow by pulsation due to cerebral parenchymal damages. (author)

  5. The importance of human FcgammaRI in mediating protection to malaria.

    Directory of Open Access Journals (Sweden)

    Richard S McIntosh

    2007-05-01

    Full Text Available The success of passive immunization suggests that antibody-based therapies will be effective at controlling malaria. We describe the development of fully human antibodies specific for Plasmodium falciparum by antibody repertoire cloning from phage display libraries generated from immune Gambian adults. Although these novel reagents bind with strong affinity to malaria parasites, it remains unclear if in vitro assays are predictive of functional immunity in humans, due to the lack of suitable animal models permissive for P. falciparum. A potentially useful solution described herein allows the antimalarial efficacy of human antibodies to be determined using rodent malaria parasites transgenic for P. falciparum antigens in mice also transgenic for human Fc-receptors. These human IgG1s cured animals of an otherwise lethal malaria infection, and protection was crucially dependent on human FcgammaRI. This important finding documents the capacity of FcgammaRI to mediate potent antimalaria immunity and supports the development of FcgammaRI-directed therapy for human malaria.

  6. The experiences to improve plant performance and reliability of Ko-Ri nuclear power plants

    International Nuclear Information System (INIS)

    Kang, Ho Weon

    1998-01-01

    This paper provides a discussion of the lessons learned from operational experience and the future plans to improve performance of the Ko-Ri plant. To operate nuclear power plants safely with good performance is the only way to mitigate the negative image of nuclear power generation to the public and to enhance the economical benefit compared to other electrical generation method. Therefore, in a continuous effort to overcome a negative challenge from outside, we have driven an aggressive 'OCTF' campaign as part of safety. As a result of our efforts, the following remarkable achievements have been accomplished. (1) 3 times of OCTF during recent three years (2) Selected twice as a top notch power plant on the list of NEI magazine in terms of plant capacity factor (3) No scram recorded in 1997 for all 4 units at Ko-Ri site. Ko-Ri is now undergoing the large scale plant betterment projects for retaking-off our operating performance to the level of new challenge target. Such improvement of critical components in the reactor coolant system and turbine system greatly contribute to increase the safety and reliability of the plant and to shortening of the planned outage period as well as to reduction of radiation exposure and radwaste. (Cho, G. S.). 5 tabs., 10 figs

  7. Studying astrophysical reactions with low-energy RI beams at CRIB

    Directory of Open Access Journals (Sweden)

    Yamaguchi H.

    2016-01-01

    Full Text Available Studies on nuclear astrophysics, nuclear structure, and other interests have been performed using the radioactive-isotope (RI beams at the low-energy RI beam separator CRIB, operated by Center for Nuclear Study (CNS, the University of Tokyo. A typical measurement performed at CRIB is the elastic resonant scattering with the inverse kinematics. One recent experiment was on the α resonant scattering with 7Li and 7Be beams. This study is related to the astrophysical 7Li/7Be(α,γ reactions, important at hot p-p chain and νp-process in supernovae. There have also been measurements based on other experimental methods. The first THM measurement using an RI beam has been performed at CRIB, to study the 18F(p, α15O reaction at astrophysical energies via the three body reaction 2H(18F, α15On. The 18F(p, α 15O reaction rate is crucial to understand the 511-keV γ-ray production in nova explosion phenomena, and we successfully evaluated the reaction cross section at novae temperature and below experimentally for the first time.

  8. Some Challenges of an “Upside Down” Nitrogen Budget – Science and Management in Greenwich Bay, RI (USA)

    Science.gov (United States)

    When nutrients impact estuarine water quality, scientists and managers instinctively focus on quantifying and controlling land-based sources. However, in Greenwich Bay, RI, the estuary opens onto a larger and more intensively fertilized coastal water body (Narragansett Bay). Prev...

  9. Isamaaline tundmus : Eesti ja Soome kirjamees Jüri Tilk ehk Yrjö Virula / Anu Pallas

    Index Scriptorium Estoniae

    Pallas, Anu, 1960-

    2010-01-01

    Avaliku elu tegelasest, ajakirjanikust ja karskuskirjanduse rajajast Jüri Tilgast, kes 19. sajandi lõpul töötas aktiivselt üldtuntud rahvajuhtide kõrval, olles ka Ado Grenzsteini lähim aatekaaslane

  10. Metoodika väljatöötamine konfliktide uurimiseks äriühingute valitsemisel / Kristo Viksi

    Index Scriptorium Estoniae

    Viksi, Kristo

    2005-01-01

    2004. a. Eesti erialases ajakirjanduses ilmunud artiklite analüüsist, millest selgus, millised konfliktid esinevad Eesti äriühingute valitsemises, millised on nende tunnused ja kuidas neid on lahendatud

  11. Uudised : Lassmann Konservatooriumide Assotsiatsiooni juhatuses. Algab "Con brio 2000". Erkki-Sven Tüüri autorikontsert / Annika Koppel

    Index Scriptorium Estoniae

    Koppel, Annika

    2000-01-01

    P. Lassmann valiti Euroopa Konservatooriumide Assotsiatsiooni juhatuse liikmeks. Eesti noorte interpreetide konkurssfestivalist "Con brio 2000". Tallinna metodisti kirikus toimub 24. nov. E.-S. Tüüri autorikontsert

  12. Functional characterization of the high affinity IgG Receptor : making heads and tails of FcγRI

    NARCIS (Netherlands)

    van der Poel, C.E.

    2011-01-01

    This thesis focuses on human FcγRI, a high affinity receptor for antibodies of the IgG isotype. IgG is the most abundant antibody type in blood and all currently FDA approved therapeutic antibodies are of the IgG isotype. FcγRI, a member of the activating Fcγ receptors, exists as a complex of a

  13. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... Skip to common links HHS U.S. Department of Health and Human Services U.S. Food and Drug Administration A to Z Index Follow FDA En Español Search FDA Submit search ... & Health Antimicrobial Resistance Animation of Antimicrobial Resistance Share Tweet ...

  14. Evaluation of inventory change report (ICR) in 2008/2009 - 2012/2013 in MBA.RI-B

    International Nuclear Information System (INIS)

    Agustinus Suprijanto; Suratno; Sigit Pramana

    2013-01-01

    Evaluation has been performed for Inventory Change Report (ICR) in 2008/2009 - 2012/2013 in MBA.RI-B (MBA = Material Balance Area) (RI-B = Center for Accelerator and Material Process Technology). The evaluation performed on the inventory change report of nuclear material document. Changes in inventories occur when there is acceptance or shipment of nuclear materials outside nuclear facilities. Successive reports changes in inventory of nuclear material in 2008/2009 comprised 3 sheets ICR document numbers (153, 154 and 155), in 2009/2010 comprised 1 sheet ICR document number (159), in 2010/2011 comprised 3 sheets ICR document numbers (164, 165 and 166), and in 2012/2013 comprised 2 sheets ICR document numbers (175 and 176). From these data report changes in inventory of nuclear material can be concluded that in MBA.RI-B has been the displacement of nuclear material activities includes receipt of nuclear material from other nuclear facilities and shipments of nuclear materials out of facilities for research and development includes receipt 4 times from RI-E and 1 times from RI-A and 3 times shipment to RI-E. (author)

  15. Development of an IgG4-RD Responder Index

    Directory of Open Access Journals (Sweden)

    Mollie N. Carruthers

    2012-01-01

    Full Text Available IgG4-related disease (IgG4-RD is a multiorgan inflammatory disease in which diverse organ manifestations are linked by common histopathological and immunohistochemical features. Prospective studies of IgG4-RD patients are required to clarify the natural history, long-term prognosis, and treatment approaches in this recently recognized condition. Patients with IgG4-RD have different organ manifestations and are followed by multiple specialties. Divergent approaches to the assessment of patients can complicate the interpretation of studies, emphasizing the critical need for validated outcome measures, particularly assessments of disease activity and response to treatment. We developed a prototype IgG4-RD Responder Index (IgG4-RD RI based on the approach used in the development of the Birmingham Vasculitis Activity Score for Wegener’s granulomatosis (BVAS/WG. The IgG4-RD RI was refined by members of the International IgG4-RD Symposium Organizing Committee in a paper case exercise. The revised instrument was applied retrospectively to fifteen IgG4-RD patients at our institution. Those scores were compared to physician’s global assessment scale for the same visits. This paper describes the philosophy and goals of the IgG4-RD RI, the steps in the development of this instrument to date, and future plans for validation of this instrument as an outcome measure.

  16. Eluruumi üürniku õiguste kaitse üüri ühepoolse suurendamise ja ebamõistliku suuruse korral : [bakalaureusetöö] / Martin Kalberg ; Tartu Ülikooli Õigusinstituut ; juhendaja: Kalev Saare

    Index Scriptorium Estoniae

    Kalberg, Martin

    2006-01-01

    Üüri suuruse ajalooline ülevaade ja võrdlus, üüri suurus eluruumi üürilepingu olulise osana, üüri ühepoolse suurendamise võimalused, üürniku vaidlustamisvõimalused üüri suurendamise korral

  17. Gestational Diabetes Mellitus Worsens the Profile of Cardiometabolic Risk Markers and Decrease Indexes of Beta-Cell Function Independently of Insulin Resistance in Nondiabetic Women with a Parental History of Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Alina Sokup

    2014-01-01

    Full Text Available Background. Women with a history of both parental type 2 diabetes (pt2DM and previous gestational diabetes (pGDM represent a group at high risk of cardiovascular events. We hypothesized that pGDM changes cardiometabolic risk markers levels as well as theirs associations with glucose indices in nondiabetic pt2DM women. Methods. Anthropometric parameters, glucose regulation (OGTT, insulin resistance (HOMA-IR, beta-cell function, lipid levels, parameters of endothelial dysfunction, and inflammation were evaluated in 55 women with pt2DM, 40 with both pt2DM and pGDM 2–24 months postpartum, and 35 controls. Results. Prediabetes was diagnosed more frequently in women with both pt2DM and pGDM in comparison with women with only pt2DM (10 versus 8, P=0.04. The pGDM group had higher LDL-cholesterol, sICAM-1, tPa Ag, fibrinogen, and lower beta-cell function after adjustment for HOMA-IR, in comparison with pt2DM group. In pt2DM group postchallenge glucose correlated independently with hsCRP and in pGDM group fasting glucose with HOMA-IR. Conclusions. pGDM exerts a combined effect on cardiometabolic risk markers in women with pt2DM. In these women higher LDL-cholesterol, fibrinogen, sICAM-1, tPa Ag levels and decreased beta cell function are associated with pGDM independently of HOMA-IR index value. Fasting glucose is an important cardiometabolic risk marker and is independently associated with HOMA-IR.

  18. The real limits to marine life: a further critique of the Respiration Index

    Science.gov (United States)

    Seibel, B. A.; Childress, J. J.

    2013-05-01

    The recently proposed "Respiration Index" (RI = log PO2/PCO2) suggests that aerobic metabolism is limited by the ratio of reactants (oxygen) to products (carbon dioxide) according to the thermodynamics of cellular respiration. Here, we demonstrate further that, because of the large standard free energy change for organic carbon oxidation (ΔG° = -686 kcal mol-1), carbon dioxide can never reach concentrations that would limit the thermodynamics of this reaction. A PCO2 to PO2 ratio of 10503 would be required to reach equilibrium (equilibrium constant, Keq = 10503), where ΔG = 0. Thus, a Respiration Index of -503 would be the real thermodynamic limit to aerobic life. Such a Respiration Index is never reached, either in the cell or in the environment. Moreover, cellular respiration and oxygen provision are kinetically controlled such that, within limits, environmental oxygen and CO2 concentrations have little to do with intracellular concentrations. The RI is fundamentally different from the aragonite saturation state, a thermodynamic index used to quantify the potential effect of CO2 on calcification rates, because of its failure to incorporate the equilibrium constant of the reaction. Not only is the RI invalid, but its use leads to incorrect and misleading predictions of the threat of changing oxygen and carbon dioxide to marine life. We provide a physiological framework that identifies oxygen thresholds and allows for synergistic effects of ocean acidification and global warming.

  19. The real limits to marine life: a further critique of the Respiration Index

    Directory of Open Access Journals (Sweden)

    B. A. Seibel

    2013-05-01

    Full Text Available The recently proposed "Respiration Index" (RI = log PO2/PCO2 suggests that aerobic metabolism is limited by the ratio of reactants (oxygen to products (carbon dioxide according to the thermodynamics of cellular respiration. Here, we demonstrate further that, because of the large standard free energy change for organic carbon oxidation (ΔG° = −686 kcal mol−1, carbon dioxide can never reach concentrations that would limit the thermodynamics of this reaction. A PCO2 to PO2 ratio of 10503 would be required to reach equilibrium (equilibrium constant, Keq = 10503, where ΔG = 0. Thus, a Respiration Index of −503 would be the real thermodynamic limit to aerobic life. Such a Respiration Index is never reached, either in the cell or in the environment. Moreover, cellular respiration and oxygen provision are kinetically controlled such that, within limits, environmental oxygen and CO2 concentrations have little to do with intracellular concentrations. The RI is fundamentally different from the aragonite saturation state, a thermodynamic index used to quantify the potential effect of CO2 on calcification rates, because of its failure to incorporate the equilibrium constant of the reaction. Not only is the RI invalid, but its use leads to incorrect and misleading predictions of the threat of changing oxygen and carbon dioxide to marine life. We provide a physiological framework that identifies oxygen thresholds and allows for synergistic effects of ocean acidification and global warming.

  20. Sugars profiles of different chestnut (Castanea sativa Mill.) and almond (Prunus dulcis) cultivars by HPLC-RI.

    Science.gov (United States)

    Barreira, João C M; Pereira, José Alberto; Oliveira, M Beatriz P P; Ferreira, Isabel C F R

    2010-03-01

    Sugar profiles of different almond and chestnut cultivars were obtained by high-performance liquid chromatography (HPLC), by means of a refractive index (RI) detector. A solid-liquid extraction procedure was used in defatted and dried samples. The chromatographic separation was achieved using a Eurospher 100-5 NH(2) column using an isocratic elution with acetonitrile/water (70:30, v/v) at a flow rate of 1.0 ml/min. All the compounds were separated in 16 min. The method was optimized and proved to be reproducible and accurate. Generally, more than 95% of sugars were identified for both matrixes. Sugars profiles were quite homogeneous for almond cultivars; sucrose was the main sugar (11.46 +/- 0.14 in Marcona to 22.23 +/- 0.59 in Ferragnes g/100 g of dried weight), followed by raffinose (0.71 +/- 0.05 in Ferraduel to 2.11 +/- 0.29 in Duro Italiano), glucose (0.42 +/- 0.12 in Pegarinhos two seeded to 1.47 +/- 0.19 in Ferragnes) and fructose (0.11 +/- 0.02 in Pegarinhos two seeded to 0.59 +/- 0.05 in Gloriette). Commercial cultivars proved to have higher sucrose contents, except in the case of Marcona. Nevertheless, chestnut cultivars revealed a high heterogeneity. Sucrose was the main sugar in Aveleira (22.05 +/- 1.48), Judia (23.30 +/- 0.83) and Longal (9.56 +/- 0.91), while glucose was slightly prevalent in Boa Ventura (6.63 +/- 0.49). The observed variance could serve for inter-cultivar discrimination.

  1. Fyn kinase controls Fc{epsilon}RI receptor-operated calcium entry necessary for full degranulation in mast cells

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez-Miranda, Elizabeth; Ibarra-Sanchez, Alfredo [Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados (Cinvestav), Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, CP 14330 Mexico City (Mexico); Gonzalez-Espinosa, Claudia, E-mail: cgonzal@cinvestav.mx [Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados (Cinvestav), Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, CP 14330 Mexico City (Mexico)

    2010-01-22

    IgE-antigen-dependent crosslinking of the high affinity IgE receptor (Fc{epsilon}RI) on mast cells leads to degranulation, leukotriene synthesis and cytokine production. Calcium (Ca{sup 2+}) mobilization is a sine qua non requisite for degranulation, allowing the rapid secretion of stored pro-inflammatory mediators responsible for allergy symptoms. Fyn is a Src-family kinase that positively controls Fc{epsilon}RI-induced mast cell degranulation. However, our understanding of the mechanism connecting Fyn activation to secretion of pre-synthesized mediators is very limited. We analyzed Fc{epsilon}RI-dependent Ca{sup 2+} mobilization in bone marrow-derived mast cells (BMMCs) differentiated from WT and Fyn -/- knock out mice. Fyn -/- BMMCs showed a marked defect in extracellular Ca{sup 2+} influx after Fc{epsilon}RI crosslinking but not after thapsigargin addition. High concentrations of Gadolinium (Gd{sup 3+}) partially blocked Fc{epsilon}RI-induced Ca{sup 2+} influx in WT cells but, in contrast, completely inhibited Ca{sup 2+} mobilization in Fyn -/- cells. Low concentrations of an inhibitor of the canonical transient receptor potential (TRPC) Ca{sup 2+} channels (2-aminoethoxyphenyl-borane, 2-APB) blocked Fc{epsilon}RI-induced maximal Ca{sup 2+} rise in WT but not in Fyn -/- cells. Ca{sup 2+} entry through Fyn-controlled, 2-APB sensitive channels was found to be important for full degranulation and IL-2 mRNA accumulation in WT cells. Immunoprecipitation assays showed that Fyn kinase interacts with TRPC 3/6/7 channels after IgE-antigen stimulation, but its association is not related to protein tyrosine phosphorylation. Results indicate Fyn kinase mediates the receptor-dependent activation of TRPC channels that contribute to degranulation in Fc{epsilon}RI-stimulated mast cells.

  2. Prediction of Ryznar Stability Index for Treated Water of WTPs Located on Al-Karakh Side of Baghdad City using Artificial Neural Network (ANN Technique

    Directory of Open Access Journals (Sweden)

    Awatif Soaded Alsaqqar

    2016-06-01

    Full Text Available In this research an Artificial Neural Network (ANN technique was applied for the prediction of Ryznar Index (RI of the flowing water from WTPs in Al-Karakh side (left side in Baghdad city for year 2013. Three models (ANN1, ANN2 and ANN3 have been developed and tested using data from Baghdad Mayoralty (Amanat Baghdad including drinking water quality for the period 2004 to 2013. The results indicate that it is quite possible to use an artificial neural networks in predicting the stability index (RI with a good degree of accuracy. Where ANN 2 model could be used to predict RI for the effluents from Al-Karakh, Al-Qadisiya and Al-Karama WTPs as the highest correlation coefficient were obtained 92.4, 82.9 and 79.1% respectively. For Al-Dora WTP, ANN 3 model could be used as R was 92.8%.

  3. ABORDĂRI ŞTIINŢIFICE PRIVIND DEFINIŢIA CONTROLULUI DE GESTIUNE

    Directory of Open Access Journals (Sweden)

    Maia BAJAN

    2016-12-01

    Full Text Available Controlul de gestiune a evoluat de la o activitate de control, unde se punea accent pe verificarea şi realizarea unei norme prestabilite, până la un instrument de gestionare a entităţii, care reflectă un spectru larg de probleme legate de procesul de realizare a obiectivelor. Analiza temeinică a literaturii de specialitate, autohtone şi străine, privind definiţia controlului de gestiune permite a delimita opiniile savanţilor în două grupe de abordări ştiinţifice, şi anume: clasice şi moderne. Controlul de gestiune redat prin abordări clasice se consideră drept o tehnică de calcul care asigură măsurarea performanţelor, iar prin abordări moderne se prezintă ca un instrument strategic de gestionare a entităţii pe viitor.SCIENTIFIC APPROACHES IN DEFINING MANAGEMENT CONTROLManagement control has evolved from a control activity, where the main target was to verify and realize the default standard, to an entity management tool, that reflects a wide range of problems related to the process of objectives achievement. A deep analysis of the domestic and foreign specialty literature concerning the definition of management control, allows the division of scientists’ views into two groups of scientific approaches, and mainly: classical and modern. The classical approach of management control is considered a computing which ensures the measurement of performances, while the modern approach represents a strategic tool for further entity management.

  4. Browse Author Index

    African Journals Online (AJOL)

    A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All. A. Ayuo, PO · Azodo, CC · Azonobi, RI 51 - 53 of 53 Items << < 1 2. ISSN: 2523-0816. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  5. Combined diagnosis of lateral cervical masses by RI-scintigraphy, ultrasound and CT-scanning

    International Nuclear Information System (INIS)

    Yang, Kuang-Tsuong; Yamashita, Toshio; Sasa, Hidehiko

    1984-01-01

    Careful palpation, plain X-rays and angiography are useful in the diagnosis of lateral cervical masses, but accurate preoperative evaluation sometimes needs further examinations. Recently several new auxiliary procedures have become available such as RI-scintigraphy, Ultrasound, and CT-scanning but even these may not be sufficient when used singly. When all these procedures were combined preoperatively in the case of lateral cervical masses and the results were compared with the findings at time of surgery and the pathology of the extirpated masses, acurate preoperative diagnose were possible. (author)

  6. Päästjate palk tõuseb nii nagu lubatud / Jüri Pihl

    Index Scriptorium Estoniae

    Pihl, Jüri, 1954-

    2007-01-01

    Ilmunud ka: Järva Teataja, 6. nov. 2007, lk. 2; Valgamaalane, 6. nov. 2007, lk. 2; Vooremaa, 6. nov. 2007, lk. 2; Põhjarannik, 6. nov. 2007, lk. 4; Vali Uudised, 7. nov. 2007, lk. 2; Sakala, 8. nov. 2007, lk. 2; Severnoje Poberezhje, 8. nov. 2007, lk. 2; Koit, 8. nov. 2007, lk. 6; Sõnumitooja, 14. nov. 2007, lk. 2. Siseminister Jüri Pihl lükkab ümber Keskerakonna väited, et päästeametnike palk ei tõuse ja kinnitab palgatõusu toimumist vastavalt riigieelarve seaduse eelnõule

  7. hiurn lv ri ility of upper oen temper ture nd he t udget in the southern ...

    Indian Academy of Sciences (India)

    wEehg A me sured urrents nd surf e meteorologi l p r meters h ve een o t ined for the first time in the southern f y of feng l t U xD IH xD nd IQ x lo tions long VU i during y to er EE xovem erD IWWV under fyfwi E ilot progr mmeF hese d t h ve een n lysed to ex mine the diurn l v ri ility of upper o e ni he t udget nd to estim ...

  8. Interjööri kujunduse ja moekunsti seosed ja vastasmõjud / Jane Kukk

    Index Scriptorium Estoniae

    Kukk, Jane

    2011-01-01

    Teoreetilise uurimuse eesmärgiks oli vaadelda disaini laiemalt, kõrvutades moe- ja interjööridisaini, looduskeskkonna, sotsiaalpoliitilise ja kultuuriruumi mõjutusi sellele ning jõudes järeldusele, et kõik disaini valdkonnad on tänu disainimise protsessi samale mudelile sarnased, on omavahel seotud ja võivad üksteist mõjutada, eriti tingimustes, kus moetööstus on laiendanud oma tegevust interjööri valdkonda, soovides luua terviklikku elustiili paketti tänapäeva tarbimisühiskonnas

  9. Turvalist kooliaastat - koolis, tänaval ja internetis / Jüri Pihl

    Index Scriptorium Estoniae

    Pihl, Jüri, 1954-

    2008-01-01

    Ilmunud ka: Molodjozh Estonii 1. sept. lk. 4-5, Sakala 2. sept., lk. 2, Virumaa Teataja 2. sept., lk. 11, Oma Saar 2. sept., lk. 5, Tartu Postimees 2. sept., lk. 2, Hiiu Leht 2. sept., lk. 2, Pärnu Postimees 2. sept., lk. 15, Koit 2. sept. lk. 6, Sõnumitooja 3. sept. lk. 2, Vooremaa 4. sept. lk. 2. Siseminister Jüri Pihl esitab kolm suuremat probleemi, mis vähendavad turvalisust koolis ja kooliteel: ohud liikluses, kasvav meelemürkide tarvitamine ning koolivägivald

  10. Puugravüüriklotsid kõnelevad / Jüri Hain

    Index Scriptorium Estoniae

    Hain, Jüri, 1941-

    2007-01-01

    Näitus "Sajand eesti puugravüüri klotsidel Eesti Rahvusraamatukogu kollektsioonist" rahvusraamatukogus 15. I - 3. II. Näitusel on vanim klots aastast 1842, noorim 1941. aastast. Kunstnikest (Aleksander Otto Gern, Bogdan Gottlieb Friedrich Kally, August Daugell, Eduard Magnus Jakobson, Mart Pukits, Andres Kuusk, Anton Suurkask, Arkadio Laigo, Hando Mugasto, Eduard Järv, Paul Liivak, Salome Trei, Ott Kangilaski), töödest. Näitust täiendavad Eduard Wiiralti "Tüdruku pea" (1919) kaks linoollõikeplaati

  11. Äriõigus 2008 : seaduste tekstid seisuga 01. 09. 2008 / koost. ja komment. Andrus Lauren

    Index Scriptorium Estoniae

    2008-01-01

    Kaanel sisu: Äriseadustik. Tulundusühistuseadus. TsÜS. Euroopa äriühingu (SE) määrus. SE määruse RS. Töötajate kaasamise seadus. Euroopa ühistu (SCE) määrus. SCE määruse RS. EMHÜ määrus. EMHÜ määruse RS. Konkurentsiseadus. Majandustegevuse registri seadus. Väärtpaberite keskregistri seadus. Raamatupidamise seadus. Rahapesu tõkestamise seadus. Audiitortegevuse seadus. Pankrotiseadus. - Kommentaarid lk. 365-388

  12. Poliglobulia e hidronefrosis de riñón en herradura

    OpenAIRE

    Gómez-Ferrer Lozano, A.; Navarro Antón, J.A.; Mola Arizo, M.J.; Polo i Peris, A.C.

    2005-01-01

    Presentamos el caso clínico de un paciente en el que se asoció eritrocitosis e hidronefrosis del hemirriñón derecho de un riñón en herradura. El paciente presentaba hidronefrosis masiva avanzada secundaria a obstrucción pieloureteral ocupando todo el hemiabdomen derecho. Después de la nefrectomía la masa eritrocitaria descendió a valores normales. La poliglobulia secundaria puede ser debida a una producción inadecuada de eritropoyetina y se ha descrito en asociación con patología renal de div...

  13. A Casa do Fim: um conto de José Riço Direitinho

    OpenAIRE

    Oliveira, Catarina Alexandra Monteiro de

    2003-01-01

    The book A Casa do Fim by young writer José Riço Direitinho is made up of ten short and independent stories, stories of life and, above all, of death, played by unusual characters. The writer shapes a strongly rural fictional universe, where he mingles what is real and what is fantastic. A Casa do Fim is a structurally and semantically fractured story, where deep wisdom and ancestral habits are passed on from mother to daughter. The son atones for the sins of the father, and suicide is sho...

  14. Report of the Study Group on Safety of RI and Radiation Uses

    International Nuclear Information System (INIS)

    Yamazaki, Fumio

    1977-01-01

    To grasp the present state of RI and radiation usages, a survey by questionnaire was made on the enterprises using small sealed radiation sources, the enterprises carrying out nondestructive tests with large radiation sources and the medical institutions utilizing RIs and radiation. The results of the study aiming at establishing the reasonable and adequate measures of safety management are described together with the survey results. The items studied are the legal regulations, facilities, education and training of workers, and radioactive waste management. (Mori, K.)

  15. Cardiomyopathie du péri-partum prise en charge en milieu ...

    African Journals Online (AJOL)

    Cardiomyopathie du péri-partum prise en charge en milieu Hospitalier Universitaire de Bobo-Dioulasso : aspects thérapeutiques et évolutifs. S. J-B. Tougouma, A.A. Yaméogo, A. Dembélé, G. Kinda, N.V. Yaméogo, G.R.C. Millogo, J.K. Kologo, A. Héma, Y. Kambiré, L. Savadogo, M.S. Ouédraogo, P. Zabsonré ...

  16. Utilidad del índice HOMA-IR con una sola determinación de insulinemia para diagnosticar resistencia insulínica Usefulness of HOMA-IR index with an only insulinemia determination to diagnose an insulin resistance

    Directory of Open Access Journals (Sweden)

    José Arturo Hernández Yero

    2011-08-01

    . Conclusiones: una sola determinación de insulinemia para estudiar el HOMA-IR es de utilidad en la práctica diaria, aunque resulta de mucha mayor precisión aplicar la fórmula original para una mejor reproducibilidad.Introduction: HOMA-IR index is a simple and not much invasive procedure allowing by a validated and well established formula to specify exactly a value expression of insulin resistance. To estimate the HOMA-IR index with an only numerical value of insulinemia could to present a greater variability, something that could be solved with at least the mean of three insulinemias, according to original formula. En some studies it is habitual to perform it with a single insulinemia determination. Thus, we conducted a study in patients presenting type 2 diabetes and to compare the results as regards the sensitivity and specificity with a single blood determination for insulinemia and glycemia. Objectives: to assess the sensitivity and specificity of each of insulinemia determinations performed each 5 min versus the mean of these determinations during the application of formula for HOMA-IR index. Methods: sixty patients diagnosed with type 2 diabetes attended in the Center for Diabetic Care of La Habana were studied. They had a diabetes course time lower than 5 years as average with predominance of body excess weight recruited during 6 months in a consecutive way and the carrying out of fasting insulinemias and glycemias determinations by trocar and venous blood extraction at 0,5 and 10 min for a calculation of Mathews's hemostatic model known as HOMA-IR. Results: a 88,3 % had a HOMA-IR greater than 3,2. The sensitivity of a single sample of insulinemia, although high to confirm the insulin resistance diagnosis, it is variable and specificity of one of samples was low with a 14%. There is an appropriate concordance among the positive predictor values with sensitivity and the negative predictive values with the test specificity. Conclusions: a single insulinemia

  17. Multicenter Phase II Study with Weekly Bendamustine and Paclitaxel as First- or Later-Line Therapy in Patients with Metastatic Breast Cancer: RiTa II Trial.

    Science.gov (United States)

    Loibl, Sibylle; Doering, Gabriele; Müller, Lothar; Grote-Metke, Albert; Müller, Roberto; Tomé, Oliver; Wiest, Wolfgang; Maisch, Andrea; Nekljudova, Valentina; von Minckwitz, Gunter

    2011-12-01

    The combination of bendamustine (B) and paclitaxel (P) as anthracycline-free treatment option in patients with advanced breast cancer has been evaluated in the previous RiTa I trial. The regimen of weekly B 70 mg/m(2) and P 90 mg/m(2) with a pause every 4th week was established as an effective regimen with low toxicity. The aim of the present RiTa II study was to investigate the potential of BP as anthracycline-free combination therapy. The primary objective was to determine the progression-free survival (PFS); secondary endpoints were safety, tolerability, overall response rate (ORR) and overall survival (OS). 26 patients were available, 15 received BP as first-line, 11 as beyond first-line treatment. 27% patients had triple-negative breast cancer (TNBC). Median PFS and OS were 7.3 months (95% confidence interval (CI): 5.5-10.9) and 14.9 months (95% CI: 9.9-22.9), respectively. The 1-year PFS rate was 20.3% and the 1-year OS rate 71.2%. The ORR was 42.3%, including 4 complete and 7 partial remissions. TNBC patients reached an ORR of 71.4%. Anthracycline-pretreated patients showed an ORR of 43.8%, confirming bendamustine's lack of cross-resistance to anthracycline agents. BP represents a favorable option with moderate toxicity in pretreated metastatic breast cancer and offers a possibility for application in anthracycline-pretreated and TNBC patients.

  18. Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway.

    Science.gov (United States)

    Li, Xian; Park, Soon Jin; Jin, Fansi; Deng, Yifeng; Yang, Ju Hye; Chang, Jae-Hoon; Kim, Dong-Young; Kim, Jung-Ae; Lee, Youn Ju; Murakami, Makoto; Son, Kun Ho; Chang, Hyeun Wook

    2018-06-01

    AMP-activated protein kinase (AMPK) and its upstream mediators liver kinase B1 (LKB1) and sirtuin 1 (Sirt1) are generally known as key regulators of metabolism. We have recently reported that the AMPK pathway negatively regulates mast cell activation and anaphylaxis. Tanshinone IIA (Tan IIA), an active component of Salvia miltiorrhiza extract that is currently used for the treatment of cardiovascular and cerebrovascular diseases, shows anti-diabetic activity and improves insulin resistance in db/db mice through activation of AMPK. The aim of this study was to evaluate the anti-allergic activity of Tan IIA in vivo and to investigate the underlying mechanism in vitro in the context of AMPK signaling. The anti-allergic effect of Tan IIA was evaluated using mouse bone marrow-derived mast cells (BMMCs) from AMPKα2 -/- or Sirt1 -/- mice, or BMMCs transfected with siRNAs specific for AMPKα2, LKB1, or Sirt1. AMPKα2 -/- and Sirt1 -/- mice were used to confirm the anti-allergic effect of Tan IIA in anaphylaxis in vivo. Tan IIA dose-dependently inhibited FcεRI-mediated degranulation and production of eicosanoids and cytokines in BMMCs. These inhibitory effects were diminished by siRNA-mediated knockdown or genetic deletion of AMPKα2 or Sirt1. Moreover, Tan IIA inhibited a mast cell-mediated local passive anaphylactic reaction in wild-type mice, but not in AMPKα2 -/- or Sirt1 -/- mice. In conclusion, Tan IIA suppresses FcεRI-mediated mast cell activation and anaphylaxis through activation of the inhibitory Sirt1-LKB1-AMPK pathway. Thus, Tan IIA may be useful as a new therapeutic agent for mast cell-mediated allergic diseases. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Body composition using deuterated water, index of insulin resistance and cortisol levels in Costa Rican school in the metropolitan area; Composicion corporal utilizando agua deuterada, indice de resistencia a la insulina y niveles de cortisol en escolares costarricenses del area metropolitana

    Energy Technology Data Exchange (ETDEWEB)

    Valverde Vindas, Allan Ignacio

    2014-07-01

    Body composition in the Costa Rican child population is evaluated and analyzed to determine the relationship with the index of insulin resistance and serum cortisol levels. 113 children in the metropolitan area were studied using deuterium isotope techniques as reference method for overweight and obesity. Morning cortisol levels were determined by immunoassay techniques (ELISA). The insulin resistance index of 113 Costa Rican boys and girls is obtained by the homeostatic method and the relationship between body composition with index of insulin resistance or levels of cortisol [Spanish] La composicion corporal en la poblacion infantil costarricense es evaluada y analizada para determinar la relacion con el indice de resistencia a la insulina y niveles de cortisol serico. 113 ninos y ninas del area metropolitana fueron estudiados utilizando tecnicas isotopicas de deuterio como metodo de referencia para sobrepeso y obesidad. Los niveles de cortisol matutino se han determinado mediante tecnicas inmunoensayo (ELISA). El indice resistencia a la insulina de 113 ninos y ninas costarricenses es obtenido mediante el metodo homeostatico asi como la relacion entre composicion corporal con indice de resistencia a la insulina o niveles de cortisol.

  20. Püha Jüri võitlus kapitalistliku hüdraga / Priit Hõbemägi, Andrei Hvostov

    Index Scriptorium Estoniae

    Hõbemägi, Priit, 1957-

    2009-01-01

    SDE uus esimees Jüri Pihl teatas, et sotsiaaldemokraatidel on alternatiiv seni valitsenud neoliberaalsele ideoloogiale. Autorite hinnangul hakkab J. Pihli vastasseis Reformierakonnaga olema hoopis teistsugune kui Keskerakonnaga

  1. Feasibility study on RI biochip Application to detection of risk factors of atherosclerosis

    International Nuclear Information System (INIS)

    Ko, Kyong Cheol; Choi, Mi Hee; Park, Sang Hyun; Cho, Kyung Hyun; Lee, Ki Teak

    2009-01-01

    Microarrays can be used to screen thousands of binding events in a parallel and high throughput fashion and are of major importance in discase diagnosis and drug discovery. The use of radioisotope is conventionally regarded as one of the most sensitive detection methods. Atherosclerosis is a common disorder affecting arterial blood vessels. It happens when fat, cholesterol, and other substances made in the arterial blood vessels form a hard substances called plaque. Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ), a phospholipase A 2 enzyme, is used as a marker for cardiac disease. The detection of Lp-PLA 2 was accomplished by using radioactive [ 3 H-acetyl] PAF as a substrate and a feasibility study on RI biochip application to detection of Lp-PLA 2 , a risk factors of atherosclerosis was performed. Inhibitive activity of a native plant extract was also determined by using the RI biochip. It was found to be applicable to a high-throughput screening of inhibitors for developing atherosclerosis therapeutic agents

  2. The diagnosis of cerebrospinal fluid hypovolemia. The comparison between CT myelography and RI cisternography

    International Nuclear Information System (INIS)

    Watanabe, Keisuke; Hashizume, Keiji; Inoue, Satoki; Fujiwara, Aki; Furuya, Hitoshi

    2008-01-01

    The comparison in the title is performed in cases with suspicious hypovolemia of cerebrospinal fluid (CSF) and its leak at the lumbar region is also examined in whiplash injury. Subjects are 25 cases (M 14/F 11, av. age 36.9 y) with traffic (13 cases), whiplash (4) and null (8) injuries. CT myelography (CTM) is conducted by injection of iotrolan through the lumbar puncturing needle to get 700 images of the whole spine of 1 mm slice thickness, which after animated, are observed visually. RI cisternography (RIC) is done immediately, 2 and 24 hr after injection of 10 MBq of diethylenetriamine pentaacetic acid (DTPA)-In through the puncturing needle. In 15 cases exhibiting positive RIC findings, CTM gives a positive leak at cervical and thoracic regions only in 2 cases and a false positive in other 13. In contrast, RIC fails to detect 2 cases of 4 with a leak at cervical and thoracic regions. Thus RIC is less reliable, and often observable RI accumulation at the lumbar area in RIC is not always a leak. (R.T.)

  3. Evaluation of RI images of hepatic blood flow using Tc-99m PMT

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, Hiromichi; Iwasaki, Naoya; Ichikawa, Kesato

    1988-03-01

    To evaluate the clinical significance of RI images of hepatic blood flow using Tc-99m-PMT, analysis of the RI images and estimation of hepatic blood flow were carried out in patients with various liver diseases (37 cases). After intravenous injection of Tc-99m-PMT, hepatic accumulation curve of ROI positioned at whole liver area and time activity curve of ROI positioned at celiac artery were obtained through scintillation camera images with the computer-analysed system. Hepatic blood flow coefficient (K) was calculated from the hepatic accumulation curve. Based on the differential curve calculated from the time activity curve, chronological images of arterial, portal, parenchymal and saturated parenchymal phases were obtained. Results ; 1) K was 0.50 + 0.04, 0.35 + 0.02 and 0.26 + 0.04/min in normal type, CH type and LC type respectively. These coefficients well correlated with clinical severity of hepatic diseases. 2) Perfusional phase images of the liver became poorer in accordance with progression of liver disease, while images of spleen, portal venous system and collateral channels were more clearly obtained in liver cirrhosis. This method was shown to have a potential to understanding of severity of liver disease and hepatic blood flow dynamics.

  4. Strongyloides ratti: implication of mast cell-mediated expulsion through FcεRI-independent mechanisms

    Directory of Open Access Journals (Sweden)

    Watanabe K.

    2009-09-01

    Full Text Available In order to examine whether FcεRI-dependent degranulation of intestinal mast cells is required for expulsion of intestinal nematode Strongyloides ratti, CD45 exon6-deficient (CD45-/- mice were inoculated with S. ratti. In CD45-/- mice, egg excretion in feces persisted for more than 30 days following S. ratti larvae inoculation, whereas in wild-type (CD45+/+ mice, the eggs completely disappeared by day 20 post-infection. The number of intestinal mucosal mast cells, which are known effector cells for the expulsion of S. ratti, was 75% lower in CD45-/- mice compared with that in CD45+/+ mice. Adoptive transfer of wild-type T cells from CD45+/+ mice into CD45-/- mice reduced the duration of S. ratti infection to comparable levels observed in CD45+/+ mice, with concomitant increases in intestinal mucosal mast cells. These results showed that CD45 is not involved in the effector function of intestinal mucosal mast cells against S. ratti infection. Since FcεRI-dependent degranulation of mast cells is completely impaired in these CD45 knockout mice, we conclude that FcεRIdependent degranulation is not required in the protective function of intestinal mucosal mast cells against primary infection of S. ratti.

  5. Refractive Index Sensing with D-Shaped Plastic Optical Fibers for Chemical and Biochemical Applications.

    Science.gov (United States)

    Sequeira, Filipa; Duarte, Daniel; Bilro, Lúcia; Rudnitskaya, Alisa; Pesavento, Maria; Zeni, Luigi; Cennamo, Nunzio

    2016-12-13

    We report the optimization of the length of a D-shaped plastic optical fiber (POF) sensor for refractive index (RI) sensing from a numerical and experimental point of view. The sensing principle is based on total internal reflection (TIR). POFs with 1 mm in diameter were embedded in grooves, realized in planar supports with different lengths, and polished to remove the cladding and part of the core. All D-shaped POF sensors were tested using aqueous medium with different refractive indices (from 1.332 to 1.471) through intensity-based configuration. Results showed two different responses. Considering the refractive index (RI) range (1.33-1.39), the sensitivity and the resolution of the sensor were strongly dependent on the sensing region length. The highest sensitivity (resolution of 6.48 × 10 -3 refractive index units, RIU) was obtained with 6 cm sensing length. In the RI range (1.41-1.47), the length of the sensing region was not a critical aspect to obtain the best resolution. These results enable the application of this optical platform for chemical and biochemical evanescent field sensing. The sensor production procedure is very simple, fast, and low-cost.

  6. Refractive Index Sensing with D-Shaped Plastic Optical Fibers for Chemical and Biochemical Applications

    Directory of Open Access Journals (Sweden)

    Filipa Sequeira

    2016-12-01

    Full Text Available We report the optimization of the length of a D-shaped plastic optical fiber (POF sensor for refractive index (RI sensing from a numerical and experimental point of view. The sensing principle is based on total internal reflection (TIR. POFs with 1 mm in diameter were embedded in grooves, realized in planar supports with different lengths, and polished to remove the cladding and part of the core. All D-shaped POF sensors were tested using aqueous medium with different refractive indices (from 1.332 to 1.471 through intensity-based configuration. Results showed two different responses. Considering the refractive index (RI range (1.33–1.39, the sensitivity and the resolution of the sensor were strongly dependent on the sensing region length. The highest sensitivity (resolution of 6.48 × 10−3 refractive index units, RIU was obtained with 6 cm sensing length. In the RI range (1.41–1.47, the length of the sensing region was not a critical aspect to obtain the best resolution. These results enable the application of this optical platform for chemical and biochemical evanescent field sensing. The sensor production procedure is very simple, fast, and low-cost.

  7. Integrated refractive index optical ring resonator detector for capillary electrophoresis.

    Science.gov (United States)

    Zhu, Hongying; White, Ian M; Suter, Jonathan D; Zourob, Mohammed; Fan, Xudong

    2007-02-01

    We developed a novel miniaturized and multiplexed, on-capillary, refractive index (RI) detector using liquid core optical ring resonators (LCORRs) for future development of capillary electrophoresis (CE) devices. The LCORR employs a glass capillary with a diameter of approximately 100 mum and a wall thickness of a few micrometers. The circular cross section of the capillary forms a ring resonator along which the light circulates in the form of the whispering gallery modes (WGMs). The WGM has an evanescent field extending into the capillary core and responds to the RI change due to the analyte conducted in the capillary, thus permitting label-free measurement. The resonating nature of the WGM enables repetitive light-analyte interaction, significantly enhancing the LCORR sensitivity. This LCORR architecture achieves dual use of the capillary as a sensor head and a CE fluidic channel, allowing for integrated, multiplexed, and noninvasive on-capillary detection at any location along the capillary. In this work, we used electro-osmotic flow and glycerol as a model system to demonstrate the fluid transport capability of the LCORRs. In addition, we performed flow speed measurement on the LCORR to demonstrate its flow analysis capability. Finally, using the LCORR's label-free sensing mechanism, we accurately deduced the analyte concentration in real time at a given point on the capillary. A sensitivity of 20 nm/RIU (refractive index units) was observed, leading to an RI detection limit of 10-6 RIU. The LCORR marries photonic technology with microfluidics and enables rapid on-capillary sample analysis and flow profile monitoring. The investigation in this regard will open a door to novel high-throughput CE devices and lab-on-a-chip sensors in the future.

  8. Novel method for the production of spin-aligned RI beams in projectile fragmentation reaction with the dispersion matching technique

    Energy Technology Data Exchange (ETDEWEB)

    Ichikawa, Y., E-mail: yuichikawa@phys.titech.ac.jp [Tokyo Institute of Technology, Department of Physics (Japan); Ueno, H. [RIKEN Nishina Center (Japan); Ishii, Y. [Tokyo Institute of Technology, Department of Physics (Japan); Furukawa, T. [Tokyo Metropolitan University, Department of Physics (Japan); Yoshimi, A. [Okayama University, Research Core for Extreme Quantum World (Japan); Kameda, D.; Watanabe, H.; Aoi, N. [RIKEN Nishina Center (Japan); Asahi, K. [Tokyo Institute of Technology, Department of Physics (Japan); Balabanski, D. L. [Bulgarian Academy of Sciences, Institute for Nuclear Research and Nuclear Energy (Bulgaria); Chevrier, R.; Daugas, J. M. [CEA, DAM, DIF (France); Fukuda, N. [RIKEN Nishina Center (Japan); Georgiev, G. [CSNSM, IN2P3-CNRS, Universite Paris-sud (France); Hayashi, H.; Iijima, H. [Tokyo Institute of Technology, Department of Physics (Japan); Inabe, N. [RIKEN Nishina Center (Japan); Inoue, T. [Tokyo Institute of Technology, Department of Physics (Japan); Ishihara, M.; Kubo, T. [RIKEN Nishina Center (Japan); and others

    2013-05-15

    A novel method to produce spin-aligned rare-isotope (RI) beam has been developed, that is the two-step projectile fragmentation method with a technique of dispersion matching. The present method was verified in an experiment at the RIKEN RIBF, where an RI beam of {sup 32}Al with spin alignment of 8(1) % was successfully produced from a primary beam of {sup 48}Ca, with {sup 33}Al as an intermediate nucleus. Figure of merit of the present method was found to be improved by a factor larger than 50 compared with a conventional method employing single-step projectile fragmentation.

  9. Methicillin-resistant Staphylococcus aureus (MRSA)

    Science.gov (United States)

    Methicillin-resistant Staphylococcus aureus; Hospital-acquired MRSA (HA-MRSA); Staph - MRSA; Staphylococcal - MRSA ... Centers for Disease Control and Prevention website. Methicillin-resistant Staphylococcus aureus (MRSA). www.cdc.gov/mrsa/index.html . Updated ...

  10. Efeitos de 24 semanas de treinamento resistido sobre índices da aptidão aeróbia de mulheres idosas Effects of 24 weeks of resistance training on aerobic fitness indexes of older women

    Directory of Open Access Journals (Sweden)

    Marcelo Guido

    2010-08-01

    the main way to increase these indices. Conversely, resistance training (RT is not typically prescribed for this purpose. In elderly subjects, it has been suggested that RT may increase aerobic capacity; however, the literature is controversial. The purpose of the present study was to verify the effects of 24 weeks of RT on aerobic capacity indexes of elderly women. METHOD: Fifty elderly women voluntarily took part in this study and were divided into two possible groups: control group (CG - n=25; mean age of 68.00 ± 6.38 years and training group (TG - n=25; mean age of 68.04 ± 6.78 years. All volunteers underwent cardiopulmonary exercise test on treadmill until volitional exhaustion before and after the intervention period. A split plot ANOVA test was used to examine differences within and between groups. RESULTS: It was observed that the TG exhibited significant increase in the variables time of test and oxygen uptake for both AT and exhaustion moments. The CG did not show any significant alterations for any of the dependent variables. CONCLUSIONS: It can be concluded that 24 weeks of RT are capable of promoting improvement in performance during a cardiopulmonary exercise test in a sample of elderly women. Further studies are necessary to elucidate the mechanisms responsible for these adaptations.

  11. EJSCREEN Indexes 2015 Public

    Data.gov (United States)

    U.S. Environmental Protection Agency — There is an EJ Index for each environmental indicator. There are eight EJ Indexes in EJSCREEN reflecting the 8 environmental indicators. The EJ Index names are:...

  12. EJSCREEN Indexes 2016 Public

    Data.gov (United States)

    U.S. Environmental Protection Agency — There is an EJ Index for each environmental indicator. There are eleven EJ Indexes in EJSCREEN reflecting the 11 environmental indicators. The EJ Index names are:...

  13. ri Sillart: Hea film on kui õhkõrn orhidee või maavillane parmupill : [2003. a. ilmunud artikli oluliselt täiendatud versioon] / Jüri Sillart ; intervjueerinud Margus Mikomägi

    Index Scriptorium Estoniae

    Sillart, Jüri, 1943-2011

    2013-01-01

    Filmirežissöör, -operaator ja Tallinna Ülikooli filmipedagoog eesti filmist ja enda omadest veidi lähemalt. 29. mail oleks Jüri Sillart saanud 70-aastaseks. Ka tema endiste õpilaste Elari Lendi ja Madis Reimundi meenutused

  14. Development of new auxiliary basis functions of the Karlsruhe segmented contracted basis sets including diffuse basis functions (def2-SVPD, def2-TZVPPD, and def2-QVPPD) for RI-MP2 and RI-CC calculations.

    Science.gov (United States)

    Hellweg, Arnim; Rappoport, Dmitrij

    2015-01-14

    We report optimized auxiliary basis sets for use with the Karlsruhe segmented contracted basis sets including moderately diffuse basis functions (Rappoport and Furche, J. Chem. Phys., 2010, 133, 134105) in resolution-of-the-identity (RI) post-self-consistent field (post-SCF) computations for the elements H-Rn (except lanthanides). The errors of the RI approximation using optimized auxiliary basis sets are analyzed on a comprehensive test set of molecules containing the most common oxidation states of each element and do not exceed those of the corresponding unaugmented basis sets. During these studies an unsatisfying performance of the def2-SVP and def2-QZVPP auxiliary basis sets for Barium was found and improved sets are provided. We establish the versatility of the def2-SVPD, def2-TZVPPD, and def2-QZVPPD basis sets for RI-MP2 and RI-CC (coupled-cluster) energy and property calculations. The influence of diffuse basis functions on correlation energy, basis set superposition error, atomic electron affinity, dipole moments, and computational timings is evaluated at different levels of theory using benchmark sets and showcase examples.

  15. Browse Author Index

    African Journals Online (AJOL)

    Items 51 - 100 of 535 ... A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All. A. Ayuo, PO · Azodo, CC · Azonobi, RI. B. Babalanda, JNP · Babata, AL · Badawy, M · Barasa, GB · Barasa, M · Bauman, N · Bekele, Abebe · Ben, ZS · Bera, MK · Biomdo, I · Bitta, C · Bundi, Brian · Bundi, PK · Burgert, S · Burgert, SL · Burgert ...

  16. Clinical and molecular characterization of Chilean patients with Léri-Weill dyschondrosteosis.

    Science.gov (United States)

    Rodríguez, Fernando Adrián; Unanue, Nancy; Hernandez, María Isabel; Basaure, Javiera; Heath, Karen Elise; Cassorla, Fernando

    2013-01-01

    ri-Weill dyschondrosteosis (LWD) is a mesomelic dysplasia with disproportionate short stature associated with short stature homeobox-containing gene (SHOX) haploinsufficiency. The objective of this study was to improve the diagnosis of patients with suspected LWD through molecular analysis. Twelve patients from 11 families with a clinical diagnosis of LWD were analyzed with multiplex ligation-dependent probe amplification to detect deletions and duplications of SHOX and its enhancer regions. High resolution melting and sequencing was employed to screen for mutations in SHOX coding exons. The molecular-based screening strategy applied in these patients allowed detection of five SHOX deletions and two previously unreported SHOX missense mutations. Molecular studies confirmed the clinical diagnosis of LWD in seven out of 12 patients, which provided support for therapeutic decisions and improved genetic counseling in their families.

  17. The number of FceRI receptors on basophils decreases during subcutaneous immunotherapy

    DEFF Research Database (Denmark)

    Schmid, J. M.; Dahl, R.; Hoffmann, H. J.

    2015-01-01

    Background: Allergen specific immunotherapy is the only disease modifying treatment of allergic diseases. It induces complex cellular and humoral changes leading to an inhibition of type-1 allergic reactions. Method: Twenty four young grass pollen allergic adults suffering from seasonal rhino......-conjunctivitis were randomized to receive standard subcutaneous immunotherapy (n = 18) or to an open control group (n = 6). The number of FceRI receptors on basophils was measured by quantitative analysis of indirect immunofluorescence by flow cytometry. Grass binding to basophils was measured by staining with grass......)/basophil in the treatment group (n = 0.016), while it remained constant in the control group (pre: 102424; post: 103753). We found only minor changes in maximal grass binding on the basophils. The allergen concentration leading to halfmaximum grass binding decreased slightly during SCIT, whereas the EC50...

  18. Strengthening the infrastructure for RI applications in cooperation with the IAEA

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kyung Bae; Hong, Young Don; Kim, Seung Yun; Kim, Kyoung Pyo; Lee, Jeong Kong

    2000-12-01

    The future direction for nuclear cooperation should be implemented with the aim of enhancing the status of Korea within the international society as well as carrying out the established national nuclear policy goal. Strategies for implementing cooperation with the IAEA were described into four separate parts; 'strategies for strengthening cooperation in general areas', 'strategies for implementing IAEA technical cooperation programs', 'strategies for implementing IAEA CRP programs' and 'Strategies for effective participation in the area of radiation and RI application'. As for strategies for implementing IAEA technical cooperation programs, i) expanding domestic personnel's entering into the IAEA ii) establishment of a liaison office for support of IAEA technical cooperation iii) expanding domestic experts entering into member of consultation group for a director-general of the IAEA and more participation in the international meetings iv) cooperation with IAEA's Seibersdorf Laboratories. For the strengthening of IAEA technical cooperation, strategies for effective implementation of technical cooperation programs such as i) strengthening role of national TC liaison officer ii) strengthening application of Model Project concept iii) Implementing End-user oriented programs iv) Establishment of measure to increase the TC implementation rate v) hosting of fellowship, scientific visitors, support for expert mission, were presented. Strategies for expanding domestic participation in the IAEA technical cooperation programs were also described for producing the benefits from implementing the IAEA technical cooperation programs. As for strategies for implementing the IAEA CRP programs, i) measures for active participation in the IAEA CRP programs and ii) measures for gradual participation in the IAEA CRP programs were separately described. To maximize the utilization of HANARO, a multi-purpose research reactor, the on

  19. Quaternary fault in Hwalseong-ri, Oedong-up, Gyeongju, Korea.

    Energy Technology Data Exchange (ETDEWEB)

    Ryoo, Chung-Ryul; Chwae, Uee-Chan; Choi, Sung-Ja [Korea Institute of Geoscience and Mineral Resources, Taejeon(Korea); Son, Moon [Pusan National University, Pusan(Korea)

    2001-09-01

    We describe a Quaternary fault occurring in Hwalseong-ri, Oedong-up, Gyeongju in the eastern part of Ulsan Fault Zone, Korea. This fault (Hwalseongri Fault) is developed around the contact between the early Tertiary granite and the Quaternary gravel layer. Four different faults are distinguished from west to east: (1) fault within Quaternary gravel layer, (2) fault between Quaternary gravel layer and granite, (3) fault between Quaternary gravel layer overlying granite and granite, (4) fault between granite and Quaternary layer. General strike of the fault zone vary from NNW to NE, dipping to east. Two striations, E-W and N-S, are developed. The former is related mainly to the reverse faulting, and the latter to the sinistral shearing. This fault zone was reactivated, and considered as a positive flower structure mainly by the results of the E-W compression in the southeastern part of the Korean Peninsula during Quaternary. (author). 45 refs., 6 figs.

  20. NEW BV(RI)C PHOTOMETRY FOR PRAESEPE: FURTHER TESTS OF BROADBAND PHOTOMETRIC CONSISTENCY

    International Nuclear Information System (INIS)

    Joner, Michael D.; Taylor, Benjamin J.; Laney, C. David; Van Wyk, Francois

    2011-01-01

    New BV(RI) C measurements of Praesepe made at the South African Astronomical Observatory (SAAO) are presented. When those measurements are combined with those reported in previous papers in this series, it is found that they support previously determined V zero points for Praesepe, M67, and the Hyades. Support is also found for joint (V – R) C and (R – I) C zero points established previously for Praesepe and NGC 752. For the SAAO system of standard stars, a B – V correction to the Johnson system of about –9 mmag appears to be reasonably well established. The preferred (though not definitive) V correction is about +7 mmag. For the Landolt V system, zero-point identity with the Johnson system at a 2σ level of 4.8 mmag is found, and no color term as large as 4 mmag (mag) –1 is detected. Updated CDS data files for Praesepe are briefly described.