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Sample records for resistance action committee

  1. Public affairs committee actions

    Science.gov (United States)

    The AGU Public Affairs Committee will create an ad hoc committee to consider possible AGU position statements concerning the effects of nuclear war.The action was taken at the May 31, 1983, meeting of the Committee at the AGU Spring Meeting in Baltimore. Present were Carroll Ann Hodges, Chairman, and members Thomas J. Ahrens, David Cauffman, Jared Cohon, Stamatios Krimigis, Robert Murphy, Raymond Roble, and George Shaw. Also attending were the current Congressional Fellow Arthur Weissman and SPR—Cosmic Rays Section Secretary Miriam Forman.

  2. Political action committee for scientists

    Science.gov (United States)

    Richman, Barbara T.

    Spurred by budget proposals that could severely reduce science funding (Eos, March 24, March 3, February 10), seven scientists currently serving as Congressional Science or State Department Fellows recently founded a political action committee (PAC) for scientists. The Science and Technology Political Action Committee (SCITEC-PAC) aims to make scientists more politically aware and better informed about potential legislative actions that affect research. It will also serve to ‘establish a political presence’ with respect to science, said Donald Stein, SCITEC-PAC's chairman.The organization is not a lobbying group, explained Stein, professor of neurology and psychology at Clark University and the University of Massachusetts Medical Center. ‘Lobbyists seek to influence officials by presenting information to them,’ he said, ‘while a PAC tries to influence the outcome of elections through campaign contributions of money, time, and effort in behalf of candidates that share similar goals and aspirations.’ In other words, the PAC will be a vehicle for promoting candidates for federal office who advocate strong support for scientific research and training. In addition, the PAC will develop and study science policy and budget issues and will attempt to stimulate government and private sector interest in these issues.

  3. 12 CFR 272.4 - Committee actions.

    Science.gov (United States)

    2010-01-01

    ... shall be in writing, by telephone, or electronic means; if the communication is made orally, the Secretary shall cause a written record to be made without delay. An action taken between meetings has the... to make technical corrections, such as spelling, grammar, construction, and organization (including...

  4. 28 CFR 301.307 - Notice, time and place of committee action.

    Science.gov (United States)

    2010-07-01

    ... action. 301.307 Section 301.307 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE INMATE ACCIDENT COMPENSATION Compensation for Work-Related Physical Impairment or Death § 301.307 Notice, time and place of committee action. (a) Committee action shall ordinarily occur within 60 days of...

  5. 76 FR 14402 - Draft Action Plan-A Public Health Action Plan To Combat Antimicrobial Resistance

    Science.gov (United States)

    2011-03-16

    ...-2011-0002] Draft Action Plan--A Public Health Action Plan To Combat Antimicrobial Resistance AGENCY... requesting public comment on the draft A Public Health Action Plan to Combat Antimicrobial Resistance. HHS/CDC is publishing this notice on behalf of the HHS Interagency Task Force on Antimicrobial Resistance...

  6. 76 FR 21907 - Draft Action Plan-A Public Health Action Plan To Combat Antimicrobial Resistance

    Science.gov (United States)

    2011-04-19

    ...-2011-0002] Draft Action Plan--A Public Health Action Plan To Combat Antimicrobial Resistance AGENCY... Antimicrobial Resistance (76 FR 14402). Written and electronic comments were to be received on or before April... Infectious Diseases, Division of Healthcare Quality Promotion, Office of Antimicrobial Resistance, Attn...

  7. 7 CFR 718.203 - County committee action to reconstitute a farm.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false County committee action to reconstitute a farm. 718.203 Section 718.203 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE FARM MARKETING QUOTAS, ACREAGE ALLOTMENTS, AND PRODUCTION ADJUSTMENT...

  8. 28 CFR 541.19 - Appeals from Unit Discipline Committee or Discipline Hearing Officer actions.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Appeals from Unit Discipline Committee or Discipline Hearing Officer actions. 541.19 Section 541.19 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Inmate Discipline...

  9. Action and resistance mechanisms of antibiotics: A guide for clinicians

    Directory of Open Access Journals (Sweden)

    Garima Kapoor

    2017-01-01

    Full Text Available Infections account for a major cause of death throughout the developing world. This is mainly due to the emergence of newer infectious agents and more specifically due to the appearance of antimicrobial resistance. With time, the bacteria have become smarter and along with it, massive imprudent usage of antibiotics in clinical practice has resulted in resistance of bacteria to antimicrobial agents. The antimicrobial resistance is recognized as a major problem in the treatment of microbial infections. The biochemical resistance mechanisms used by bacteria include the following: antibiotic inactivation, target modification, altered permeability, and “bypass” of metabolic pathway. Determination of bacterial resistance to antibiotics of all classes (phenotypes and mutations that are responsible for bacterial resistance to antibiotics (genetic analysis are helpful. Better understanding of the mechanisms of antibiotic resistance will help clinicians regarding usage of antibiotics in different situations. This review discusses the mechanism of action and resistance development in commonly used antimicrobials.

  10. About sensititvity: salmonella biofi lms’ resistance to disinfectants action

    Directory of Open Access Journals (Sweden)

    V. F. Marievsky

    2013-10-01

    Full Text Available Salmonella biofi lms’ resistance to the action of the disinfectants was studied. It was founded that Salmonella biofi lms, which were formed on the hard carriers during 24 hours of incubation, demanded 32-fold increase of the minimal bactericide concentration of the disinfectant with quaternary ammonium compound.

  11. Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.

    Science.gov (United States)

    Hooper, David C; Jacoby, George A

    2016-09-01

    Quinolone antimicrobials are widely used in clinical medicine and are the only current class of agents that directly inhibit bacterial DNA synthesis. Quinolones dually target DNA gyrase and topoisomerase IV binding to specific domains and conformations so as to block DNA strand passage catalysis and stabilize DNA-enzyme complexes that block the DNA replication apparatus and generate double breaks in DNA that underlie their bactericidal activity. Resistance has emerged with clinical use of these agents and is common in some bacterial pathogens. Mechanisms of resistance include mutational alterations in drug target affinity and efflux pump expression and acquisition of resistance-conferring genes. Resistance mutations in one or both of the two drug target enzymes are commonly in a localized domain of the GyrA and ParC subunits of gyrase and topoisomerase IV, respectively, and reduce drug binding to the enzyme-DNA complex. Other resistance mutations occur in regulatory genes that control the expression of native efflux pumps localized in the bacterial membrane(s). These pumps have broad substrate profiles that include other antimicrobials as well as quinolones. Mutations of both types can accumulate with selection pressure and produce highly resistant strains. Resistance genes acquired on plasmids confer low-level resistance that promotes the selection of mutational high-level resistance. Plasmid-encoded resistance is because of Qnr proteins that protect the target enzymes from quinolone action, a mutant aminoglycoside-modifying enzyme that also modifies certain quinolones, and mobile efflux pumps. Plasmids with these mechanisms often encode additional antimicrobial resistances and can transfer multidrug resistance that includes quinolones. Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.

  12. Research Ethics Committees and Participatory Action Research With Young People: The Politics of Voice.

    Science.gov (United States)

    Yanar, Zeynep M; Fazli, Mehria; Rahman, Jahanara; Farthing, Rys

    2016-04-01

    Participatory action research (PAR) is a methodological approach that seeks to maximize the participation of people whose lives it researches. It is underpinned by an ethical concern to research "with" people, rather than "on" people. However, this ethical approach to research is often, paradoxically, problematized by universities' research ethics committees (RECs). This article explores one site of tension between PAR and RECs-the requirement for anonymity for below 18-year-olds. It explores this tension by exploring a case study of a peer-to-peer research project undertaken by young women in East London, and using our own experiences and perspectives, it argues that anonymity can be unjust, disempowering, and unnecessary, and can reduce "pride." Without wanting to develop specific recommendations, given the limited scope of our case study, this article uses firsthand experiences to add weight to the broader discussions calling for a critical rethink of REC guidelines. © The Author(s) 2016.

  13. Committees

    Science.gov (United States)

    2012-11-01

    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  14. Approved Glycopeptide Antibacterial Drugs: Mechanism of Action and Resistance.

    Science.gov (United States)

    Zeng, Daina; Debabov, Dmitri; Hartsell, Theresa L; Cano, Raul J; Adams, Stacy; Schuyler, Jessica A; McMillan, Ronald; Pace, John L

    2016-12-01

    The glycopeptide antimicrobials are a group of natural product and semisynthetic glycosylated peptides that show antibacterial activity against Gram-positive organisms through inhibition of cell-wall synthesis. This is achieved primarily through binding to the d-alanyl-d-alanine terminus of the lipid II bacterial cell-wall precursor, preventing cross-linking of the peptidoglycan layer. Vancomycin is the foundational member of the class, showing both clinical longevity and a still preferential role in the therapy of methicillin-resistant Staphylococcus aureus and of susceptible Enterococcus spp. Newer lipoglycopeptide derivatives (telavancin, dalbavancin, and oritavancin) were designed in a targeted fashion to increase antibacterial activity, in some cases through secondary mechanisms of action. Resistance to the glycopeptides emerged in delayed fashion and occurs via a spectrum of chromosome- and plasmid-associated elements that lead to structural alteration of the bacterial cell-wall precursor substrates. Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.

  15. Municipal Solid Waste Recycling an Action along with Resistive Economics

    Directory of Open Access Journals (Sweden)

    Aram Tirgar

    2016-08-01

    Full Text Available Background and Objective: In the current situation, it seems that municipal solid waste recycling despite hygienic, economic and environmental aspects is important from sociopolitical aspect. The aim of this study was to determine waste recycling condition and the knowledge of households about resistive economics, as an action along with a policy.Materials and Methods: This descriptive and cross-sectional study was conducted among 330 family of Amirkola city in Mazandaran province during 2013. The samples were collected from 33 regions using cluster sampling method. The data was collected by means of researcher-made data collection sheet and analyzed using descriptive statistical indices and Chi- square test, and p<0.05 was considered as significant.Results: The results showed that the mean (SD of age were 39.1 (10.9 years and 176 (53% female. More than half of households (56.9% were recycling municipal solid waste (plastic, paper, glass, and food residue which the share of plastic, and paper were the highest. Only 59 (29% were familiar with resistive economics, but there was not any significant relation between waste recycling and their awareness of resistive economics.Conclusion: The limitation of knowledge about resistive economics, and their weakness of practice about waste recycling imply that the authorities should have definite programs in order to increase family information and participations in social issues.

  16. Old and New Glycopeptide Antibiotics: Action and Resistance

    Directory of Open Access Journals (Sweden)

    Elisa Binda

    2014-11-01

    Full Text Available Glycopeptides are considered antibiotics of last resort for the treatment of life-threatening infections caused by relevant Gram-positive human pathogens, such as Staphylococcus aureus, Enterococcus spp. and Clostridium difficile. The emergence of glycopeptide-resistant clinical isolates, first among enterococci and then in staphylococci, has prompted research for second generation glycopeptides and a flurry of activity aimed at understanding resistance mechanisms and their evolution. Glycopeptides are glycosylated non-ribosomal peptides produced by a diverse group of soil actinomycetes. They target Gram-positive bacteria by binding to the acyl-D-alanyl-D-alanine (D-Ala-D-Ala terminus of the growing peptidoglycan on the outer surface of the cytoplasmatic membrane. Glycopeptide-resistant organisms avoid such a fate by replacing the D-Ala-D-Ala terminus with D-alanyl-D-lactate (D-Ala-D-Lac or D-alanyl-D-serine (D-Ala-D-Ser, thus markedly reducing antibiotic affinity for the cellular target. Resistance has manifested itself in enterococci and staphylococci largely through the expression of genes (named van encoding proteins that reprogram cell wall biosynthesis and, thus, evade the action of the antibiotic. These resistance mechanisms were most likely co-opted from the glycopeptide producing actinomycetes, which use them to avoid suicide during antibiotic production, rather than being orchestrated by pathogen bacteria upon continued treatment. van-like gene clusters, similar to those described in enterococci, were in fact identified in many glycopeptide-producing actinomycetes, such as Actinoplanes teichomyceticus, which produces teicoplanin, and Streptomyces toyocaensis, which produces the A47934 glycopeptide. In this paper, we describe the natural and semi-synthetic glycopeptide antibiotics currently used as last resort drugs for Gram-positive infections and compare the van gene-based strategies of glycopeptide resistance among the pathogens and

  17. Finance Committee actions ready health reform debate for House, Senate floors.

    Science.gov (United States)

    1994-07-07

    The activity of the US Senate Finance Committee was reported for the health care reform bill, which was sent out of committee to the floor of the Senate on July 2, 1994. The bill out of committee did not include provision for universal insurance coverage, and included amendments that might remove abortion, family planning, and reproductive health services from the standard package of required employee benefits. Other health reform measures where reported out of the Senate Labor and Human Resources Committee, the House Ways and Means Committee, and the Education and Labor Committee, which all contained a provision for universal insurance coverage through employer mandates, a standard benefits package, and comprehensive family planning services and reproductive health care. The Labor and Human Resources bill included counseling and education for family planning. Both House bills exempted family planning services from cost sharing requirements. Abortion coverage in these three bills was covered under "services for pregnant women." The Senate Finance Committee bill adopted "market reforms" which would reduce the cost of coverage for employers. A standard benefits package would be determined by all employers, regardless of whether employers contributed to coverage. The critical point of the Senate Finance bill is that it provides the opportunity to deny services for abortion on religious or moral grounds and to deny services for contraception, AIDS treatment, or substance abuse, by making acceptance optional by states and by insurers and by employers. The House Rules Committee will begin the first week in August to reconcile differences in the House bills. The Senate will reconcile differences in some fashion, without a prescribed procedure.

  18. Building public trust: Actions to respond to the report of the Advisory Committee on human radiation experiments

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    Democratic government requires trust: people need to know and believe that the government is telling the truth. Without information about what the government is doing and why, citizens cannot exercise democratic control over government institutions. During his first year in office, President Clinton became concerned about reports that the government had conducted unethical secret human radiation experiments during the Cold War. To address this issue, in January 1994, President Clinton established the Advisory Committee on Human Radiation Experiments (ACHRE), chaired by bioethicist Dr. Ruth Faden of Johns Hopkins University. The President also directed all Federal agencies to search for records related to human subjects radiation research and provide them to the Advisory Committee. This report presents the Administration`s actions to respond to the ACHRE`s findings and recommendations.

  19. Building public trust: Actions to respond to the report of the Advisory Committee on human radiation experiments

    International Nuclear Information System (INIS)

    1997-03-01

    Democratic government requires trust: people need to know and believe that the government is telling the truth. Without information about what the government is doing and why, citizens cannot exercise democratic control over government institutions. During his first year in office, President Clinton became concerned about reports that the government had conducted unethical secret human radiation experiments during the Cold War. To address this issue, in January 1994, President Clinton established the Advisory Committee on Human Radiation Experiments (ACHRE), chaired by bioethicist Dr. Ruth Faden of Johns Hopkins University. The President also directed all Federal agencies to search for records related to human subjects radiation research and provide them to the Advisory Committee. This report presents the Administration's actions to respond to the ACHRE's findings and recommendations

  20. Pleuromutilins: Potent Drugs for Resistant Bugs-Mode of Action and Resistance.

    Science.gov (United States)

    Paukner, Susanne; Riedl, Rosemarie

    2017-01-03

    use in veterinary medicine. This review focuses on the structural characteristics, mode of action, antibacterial activity, and resistance development of this potent and novel antibacterial class for systemic use in humans. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

  1. Citizen Action Can Help the Code Adoption Process for Radon-Resistant New Construction: Decatur, Alabama

    Science.gov (United States)

    Adopting a code requiring radon-resistant new construction (RRNC) in Decatur, Alabama, took months of effort by four people. Their actions demonstrate the influence that passionate residents can have on reversing a city council’s direction.

  2. Old and New Glycopeptide Antibiotics: Action and Resistance

    OpenAIRE

    Binda, Elisa; Marinelli, Flavia; Marcone, Giorgia Letizia

    2014-01-01

    Glycopeptides are considered antibiotics of last resort for the treatment of life-threatening infections caused by relevant Gram-positive human pathogens, such as Staphylococcus aureus, Enterococcus spp. and Clostridium difficile. The emergence of glycopeptide-resistant clinical isolates, first among enterococci and then in staphylococci, has prompted research for second generation glycopeptides and a flurry of activity aimed at understanding resistance mechanisms and their evolution. Glycop...

  3. Lincosamides: Chemical structure, biosynthesis, mechanism of action, resistance, and applications

    Czech Academy of Sciences Publication Activity Database

    Spížek, Jaroslav; Řezanka, Tomáš

    2017-01-01

    Roč. 133, June 1 SI (2017), s. 20-28 ISSN 0006-2952 Institutional support: RVO:61388971 Keywords : Lincosamides * Chemical structure * Biosynthesis and mechanism of action Subject RIV: EE - Microbiology, Virology OBOR OECD: Microbiology Impact factor: 4.581, year: 2016

  4. Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci.

    Science.gov (United States)

    Miller, William R; Bayer, Arnold S; Arias, Cesar A

    2016-11-01

    Lipopeptides are natural product antibiotics that consist of a peptide core with a lipid tail with a diverse array of target organisms and mechanisms of action. Daptomycin (DAP) is an example of these compounds with specific activity against Gram-positive organisms. DAP has become increasingly important to combat infections caused by Gram-positive bacteria because of the presence of multidrug resistance in these organisms, particularly in methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). However, emergence of resistance to DAP during therapy is a well-described phenomenon that threatens the clinical use of this antibiotic, limiting further the therapeutic options against both MRSA and VRE. This work will review the historical aspects of the development of DAP, as well as the current knowledge on its mechanism of action and pathways to resistance in a clinically relevant context. Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.

  5. [Fluoroquinolones in ophthalmology: mechanisms of action and resistance].

    Science.gov (United States)

    Labetoulle, M; Chiquet, C

    2008-10-01

    The arrival of fluoroquinolones in the 1980s aroused enormous enthusiasm in the medical community, justified by the spectrum of antibacterial activity, good tolerance, and wide distribution in tissues, even after oral administration. However, the extensive use of these new antibiotiques finally ended in emerging resistance, which limits the efficiency of all the molecules in the class, including those that have appeared in the last few years. Ocular diseases also benefited from the emergence of fluoroquinolones, notably for topical treatments. It is now mandatory to adapt the prescriptions to the best indications, in order to protect the vast therapeutic potential of these molecules.

  6. Resistance in Action Learning: Struggling with Self-Efficacy and the Social Self--and What about the Set Advisor?

    Science.gov (United States)

    Burger, Ulrike

    2013-01-01

    This account of practice explores the concept of resistance in action learning. Resistance is conceptualized as an attempt of self-protection that is manifested in action learners' struggles with their sense of self-efficacy and their social Self. These struggles are an inherent part of the action learning process and may elicit defensive…

  7. 76 FR 63927 - Interagency Task Force on Antimicrobial Resistance (ITFAR): An Update on A Public Health Action...

    Science.gov (United States)

    2011-10-14

    ... Task Force on Antimicrobial Resistance (ITFAR): An Update on A Public Health Action Plan to Combat... outlined in A Public Health Action Plan to Combat Antimicrobial Resistance (Action Plan) and solicit... (AR) in recognition of the increasing importance of AR as a public health threat. The Task Force is co...

  8. Vanillin selectively modulates the action of antibiotics against resistant bacteria.

    Science.gov (United States)

    Bezerra, Camila Fonseca; Camilo, Cicera Janaine; do Nascimento Silva, Maria Karollyna; de Freitas, Thiago Sampaio; Ribeiro-Filho, Jaime; Coutinho, Henrique Douglas Melo

    2017-12-01

    The treatment of infections caused by microorganisms that are resistant to antibiotics represent one of the main challenges of medicine today, especially due to the inefficacy of long-term drug therapy. In the search for new alternatives to treat these infections, many researchers have been looking for new substances derived from natural products to replace, or be used in combination with conventional antibiotics. Vanillin is a phenolic compound whose antimicrobial activity has been used in the elimination of pathogens present in fruits and vegetables. However, its antibacterial and modulating properties remain to be characterized. Therefore, this work aimed to evaluate the antibacterial activity and analyze the modulator activity of vanillin in association with conventional antibiotics. The antimicrobial activity of vanillin was evaluated using the microdilution method to determine the Minimum Inhibitory Concentration (MIC) Standard strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and multi-resistant strains of Escherichia coli 06, Staphylococcus aureus 10, Pseudomonas aeruginosa 24 were used in this study. The antibiotic modulating effect was analyzed by combining vanillin with Norfloxacin, Imipenem, Gentamicin, Erythromycin and Tetracycline against the following multiresistant bacteria strains: Escherichia coli 06, Staphylococcus aureus 10 and Pseudomonas aeruginosa 24. Data were analyzed using the ANOVA test of two tracks followed by the post hoc Bonferroni test. Vanillin presented CIMs ≥1024μg/mL against all tested strains demonstrating that it did not present significant antibacterial activity. However, modulated the activity of gentamicin and imipenem against S. aureus and E. coli, causing a synergistic effect, but did not affect the activity of norfloxacin, tetracycline and erythromycin against these same microorganisms. A synergistic effect was also obtained from the association of vanillin with norfloxacin against P

  9. Vasodilatation with pinacidil. Mode of action in rat resistance vessels

    International Nuclear Information System (INIS)

    Videbaek, L.M.; Aalkjaer, C.; Mulvany, M.J.

    1988-01-01

    Pinacidil is a newly developed antihypertensive vasodilator, proposed to belong to the new group of smooth muscle relaxants, the K+ channel openers. The in vitro effects of pinacidil on induced tone, smooth muscle membrane potential and 86 Rb and 42 K efflux from rat resistance vessels (internal diameter about 200 microns) were studied. Tone induced with noradrenaline was concentration-dependently inhibited by pinacidil. Responses to electrical field stimulation were also inhibited. However, tone induced with high K+ depolarization, noradrenaline in the presence of high K+, caffeine-induced contractions and noradrenaline contractions in the presence of felodipine were little affected by pinacidil. Pinacidil caused concentration-dependent hyperpolarisation of the resting smooth muscle. Pinacidil caused only a small and transient increase of the 86 Rb efflux rate constant, while the same concentrations of pinacidil produced a significant increase in the 42 K efflux rate constant. Our results seem to indicate that the relaxant effect of pinacidil is the result of an increase in K+ permeability, thus causing hyperpolarisation and relaxation. The opened K+ channels appear to be selective for K+ over Rb+

  10. A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway.

    Science.gov (United States)

    Wang, Kathy K; Stone, Laura K; Lieberman, Tami D; Shavit, Michal; Baasov, Timor; Kishony, Roy

    2016-02-01

    Hybrid drugs are a promising strategy to address the growing problem of drug resistance, but the mechanism by which they modulate the evolution of resistance is poorly understood. Integrating high-throughput resistance measurements and genomic sequencing, we compared Escherichia coli populations evolved in a hybrid antibiotic that links ciprofloxacin and neomycin B with populations evolved in combinations of the component drugs. We find that populations evolved in the hybrid gain less resistance than those evolved in an equimolar mixture of the hybrid's components, in part because the hybrid evades resistance mediated by the multiple antibiotic resistance (mar) operon. Furthermore, we find that the ciprofloxacin moiety of the hybrid inhibits bacterial growth whereas the neomycin B moiety diminishes the effectiveness of mar activation. More generally, comparing the phenotypic and genotypic paths to resistance across different drug treatments can pinpoint unique properties of new compounds that limit the emergence of resistance. © The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance.

    Science.gov (United States)

    Ramamoorthy, Sivapriya; Cidlowski, John A

    2013-01-01

    Glucocorticoids regulate a variety of physiological processes, and are commonly used to treat disorders of inflammation, autoimmune diseases, and cancer. Glucocorticoid action is predominantly mediated through the classic glucocorticoid receptor (GR), but sensitivity to glucocorticoids varies among individuals, and even within different tissues from the same individual. The molecular basis of this phenomenon can be partially explained through understanding the process of generating bioavailable ligand and the molecular heterogeneity of the GR. The molecular mechanisms that regulate glucocorticoid action highlight the dynamic nature of hormone signaling and provide novel insights into genomic glucocorticoid actions and glucocorticoid sensitivity. Although glucocorticoids are highly effective for therapeutic purposes, long-term and/or high-dose glucocorticoid administration often leads to reduced glucocorticoid sensitivity or resistance. Here, we summarize our current understanding of the mechanisms that modulate glucocorticoid sensitivity and resistance with a focus on GR-mediated signaling. Copyright © 2013 S. Karger AG, Basel.

  12. Role of sialic acid in insulin action and the insulin resistance of diabetes mellitus

    International Nuclear Information System (INIS)

    Salhanick, A.I.; Amatruda, J.M.

    1988-01-01

    Adipocytes treated with neuraminidase show markedly reduced responsiveness to insulin without any alteration in insulin binding. In addition, several studies have separately demonstrated both insulin resistance and decreases in membrane sialic acid content and associated biosynthetic enzymes in diabetes mellitus. In the present study, the authors investigated the role that sialic acid residues may play in insulin action and in the hepatic insulin resistance associated with nonketotic diabetes. Primary cultures of hepatocytes from normal rats treated with neuraminidase demonstrated a dose-dependent decrease in insulin-stimulated lipogenesis. At a concentration of neuraminidase that decreases insulin action by 50%, 23% of total cellular sialic acid content was released. Neuraminidase-releasable sialic acid was significantly decreased in hepatocytes from diabetic rats and this was associated with significant insulin resistance. Treatment of hepatocytes from diabetic rats with cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NANA) enhanced insulin responsiveness 39%. The enhanced insulin responsiveness induced by CMP-NANA was blocked by cytidine 5'-monophosphate (CMP) suggesting that the CMP-NANA effect was catalyzed by a cell surface sialyl-transferase. CMP reduced neuraminidase-releasable [ 14 C]sialic acid incorporation into hepatocytes by 43%. The data demonstrate a role for cell surface sialic acid residues in hepatic insulin action and support a role for decreased cell surface sialic acid residues in the insulin resistance of diabetes mellitus

  13. 75 FR 30002 - Federal Advisory Committee; Threat Reduction Advisory Committee

    Science.gov (United States)

    2010-05-28

    ... Office of the Secretary Federal Advisory Committee; Threat Reduction Advisory Committee AGENCY: Department of Defense (DoD). ACTION: Renewal of Federal advisory committee. SUMMARY: Under the provisions of the Federal Advisory Committee Act of 1972, (5 U.S.C. Appendix), the Government in the Sunshine Act of...

  14. The Role of Stewardship in Addressing Antibacterial Resistance: Stewardship and Infection Control Committee of the Antibacterial Resistance Leadership Group.

    Science.gov (United States)

    Anderson, Deverick J; Jenkins, Timothy C; Evans, Scott R; Harris, Anthony D; Weinstein, Robert A; Tamma, Pranita D; Han, Jennifer H; Banerjee, Ritu; Patel, Robin; Zaoutis, Theoklis; Lautenbach, Ebbing

    2017-03-15

    Antibacterial resistance is increasing globally and has been recognized as a major public health threat. Antibacterial stewardship is the coordinated effort to improve the appropriate use of antibiotics with the aim to decrease selective pressure for multidrug-resistant organisms in order to preserve the utility of antibacterial agents. This article describes the activities of the Antibacterial Resistance Leadership Group (ARLG) in the area of antibacterial stewardship. To date, the ARLG has focused intensely on development of rapid diagnostic tests, which (when coupled with educational and institutional initiatives) will enable the robust stewardship that is needed to address the current crisis of antibacterial resistance. In addition to exploring the effectiveness of stewardship techniques in community hospitals, the ARLG has also developed strategy trials to assess the feasibility of reducing antibacterial usage while preserving patient outcome. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

  15. Antibiotic resistance modulation and modes of action of (--α-pinene in Campylobacter jejuni.

    Directory of Open Access Journals (Sweden)

    Jasna Kovač

    Full Text Available The aim of the study was to investigate the mode of action of (--α-pinene in terms of its modulation of antibiotic resistance in Campylobacter jejuni. Broth microdilution and ethidium bromide accumulation assays were used to evaluate the (--α-pinene antimicrobial activity, modulation of antimicrobial resistance, and inhibition of antimicrobial efflux. The target antimicrobial efflux systems were identified using an insertion mutagenesis approach, and C. jejuni adaptation to (--α-pinene was evaluated using DNA microarrays. Knock-out mutants of the key up-regulated transcriptional regulators hspR and hrcA were constructed to investigate their roles in C. jejuni adaptation to several stress factors, including osmolytes, and pH, using Biolog phenotypical microarrays. Our data demonstrate that (--α-pinene efficiently modulates antibiotic resistance in C. jejuni by decreasing the minimum inhibitory concentrations of ciprofloxacin, erythromycin and triclosan by up to 512-fold. Furthermore, (--α-pinene promotes increased expression of cmeABC and another putative antimicrobial efflux gene, Cj1687. The ethidium bromide accumulation was greater in the wild-type strain than in the antimicrobial efflux mutant strains, which indicates that these antimicrobial efflux systems are a target of action of (--α-pinene. Additionally, (--α-pinene decreases membrane integrity, which suggests that enhanced microbial influx is a secondary mode of action of (--α-pinene. Transcriptomic analysis indicated that (--α-pinene disrupts multiple metabolic pathways, and particularly those involved in heat-shock responses. Thus, (--α-pinene has significant activity in the modulation of antibiotic resistance in C. jejuni, which appears to be mediated by multiple mechanisms that include inhibition of microbial efflux, decreased membrane integrity, and metabolic disruption. These data warrant further studies on (--α-pinene to develop its use in the control of antibiotic

  16. Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action

    Directory of Open Access Journals (Sweden)

    Carlet Jean

    2012-02-01

    Full Text Available Abstract Resistance to antibiotics has increased dramatically over the past few years and has now reached a level that places future patients in real danger. Microorganisms such as Escherichia coli and Klebsiella pneumoniae, which are commensals and pathogens for humans and animals, have become increasingly resistant to third-generation cephalosporins. Moreover, in certain countries, they are also resistant to carbapenems and therefore susceptible only to tigecycline and colistin. Resistance is primarily attributed to the production of beta-lactamase genes located on mobile genetic elements, which facilitate their transfer between different species. In some rare cases, Gram-negative rods are resistant to virtually all known antibiotics. The causes are numerous, but the role of the overuse of antibiotics in both humans and animals is essential, as well as the transmission of these bacteria in both the hospital and the community, notably via the food chain, contaminated hands, and between animals and humans. In addition, there are very few new antibiotics in the pipeline, particularly for Gram-negative bacilli. The situation is slightly better for Gram-positive cocci as some potent and novel antibiotics have been made available in recent years. A strong and coordinated international programme is urgently needed. To meet this challenge, 70 internationally recognized experts met for a two-day meeting in June 2011 in Annecy (France and endorsed a global call to action ("The Pensières Antibiotic Resistance Call to Action". Bundles of measures that must be implemented simultaneously and worldwide are presented in this document. In particular, antibiotics, which represent a treasure for humanity, must be protected and considered as a special class of drugs.

  17. Binge Drinking Induces Whole-Body Insulin Resistance by Impairing Hypothalamic Insulin Action

    Science.gov (United States)

    Lindtner, Claudia; Scherer, Thomas; Zielinski, Elizabeth; Filatova, Nika; Fasshauer, Martin; Tonks, Nicholas K.; Puchowicz, Michelle; Buettner, Christoph

    2013-01-01

    Individuals with a history of binge drinking have an increased risk of developing the metabolic syndrome and type 2 diabetes. Whether binge drinking impairs glucose homeostasis and insulin action is unknown. To test this, we treated Sprague-Dawley rats daily with alcohol (3 g/kg) for three consecutive days to simulate human binge drinking and found that these rats developed and exhibited insulin resistance even after blood alcohol concentrations had become undetectable. The animals were resistant to insulin for up to 54 hours after the last dose of ethanol, chiefly a result of impaired hepatic and adipose tissue insulin action. Because insulin regulates hepatic glucose production and white adipose tissue lipolysis, in part through signaling in the central nervous system, we tested whether binge drinking impaired brain control of nutrient partitioning. Rats that had consumed alcohol exhibited impaired hypothalamic insulin action, defined as the ability of insulin infused into the mediobasal hypothalamus to suppress hepatic glucose production and white adipose tissue lipolysis. Insulin signaling in the hypothalamus, as assessed by insulin receptor and AKT phosphorylation, decreased after binge drinking. Quantitative polymerase chain reaction showed increased hypothalamic inflammation and expression of protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling. Intracerebroventricular infusion of CPT-157633, a small-molecule inhibitor of PTP1B, prevented binge drinking–induced glucose intolerance. These results show that, in rats, binge drinking induces systemic insulin resistance by impairing hypothalamic insulin action and that this effect can be prevented by inhibition of brain PTP1B. PMID:23363978

  18. Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group.

    Science.gov (United States)

    Tsalik, Ephraim L; Petzold, Elizabeth; Kreiswirth, Barry N; Bonomo, Robert A; Banerjee, Ritu; Lautenbach, Ebbing; Evans, Scott R; Hanson, Kimberly E; Klausner, Jeffrey D; Patel, Robin

    2017-03-15

    Diagnostics are a cornerstone of the practice of infectious diseases. However, various limitations frequently lead to unmet clinical needs. In most other domains, diagnostics focus on narrowly defined questions, provide readily interpretable answers, and use true gold standards for development. In contrast, infectious diseases diagnostics must contend with scores of potential pathogens, dozens of clinical syndromes, emerging pathogens, rapid evolution of existing pathogens and their associated resistance mechanisms, and the absence of gold standards in many situations. In spite of these challenges, the importance and value of diagnostics cannot be underestimated. Therefore, the Antibacterial Resistance Leadership Group has identified diagnostics as 1 of 4 major areas of emphasis. Herein, we provide an overview of that development, highlighting several examples where innovation in study design, content, and execution is advancing the field of infectious diseases diagnostics. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

  19. Fluoroquinolone Action against Mycobacteria: Effects of C-8 Substituents on Growth, Survival, and Resistance

    Science.gov (United States)

    Dong, Yuzhi; Xu, Chen; Zhao, Xilin; Domagala, John; Drlica, Karl

    1998-01-01

    Fluoroquinolones trap gyrase on DNA as bacteriostatic complexes from which lethal DNA breaks are released. Substituents at the C-8 position increase activities of N-1-cyclopropyl fluoroquinolones against several bacterial species. In the present study, a C-8-methoxyl group improved bacteriostatic action against gyrA (gyrase-resistant) strains of Mycobacterium tuberculosis and M. bovis BCG. It also enhanced lethal action against gyrase mutants of M. bovis BCG. When cultures of M. smegmatis, M. bovis BCG, and M. tuberculosis were challenged with a C-8-methoxyl fluoroquinolone, no resistant mutant was recovered under conditions in which more than 1,000 mutants were obtained with a C-8-H control. A C-8-bromo substituent also increased bacteriostatic and lethal activities against a gyrA mutant of M. bovis BCG. When lethal activity was normalized to bacteriostatic activity, the C-8-methoxyl compound was more bactericidal than its C-8-H control, while the C-8-bromo fluoroquinolone was not. The C-8-methoxyl compound was also found to be more effective than the C-8-bromo fluoroquinolone at reducing selection of resistant mutants when each was compared to a C-8-H control over a broad concentration range. These data indicate that a C-8-methoxyl substituent, which facilitates attack of first-step gyrase mutants, may help make fluoroquinolones effective antituberculosis agents. PMID:9797236

  20. 77 FR 24728 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2012-04-25

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Security Telecommunications Advisory Committee (NSTAC) will meet on Tuesday, May 15, 2012, in Washington DC... to national security and emergency preparedness telecommunications policy. Agenda: The committee will...

  1. 78 FR 28237 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2013-05-14

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Security Telecommunications Advisory Committee (NSTAC) will meet on Wednesday, May 22, 2013, in Washington..., National Security Telecommunications Advisory Committee, National Protection and Programs Directorate...

  2. Political struggles in disability’s visibilization: direct actions, counter-conducts and resistance

    Directory of Open Access Journals (Sweden)

    Alejandro Martín Contino

    2013-12-01

    Full Text Available Since the examination of the current situation of persons under disability, the hypothesis of conceiving disability as a device is carried out, according to the French philosopher Michel Foucault. Thus, the negative aspects experienced by subjects in situation of disability, not implying malfunction of public policy, would be logical and expected effects, the typical function of a disability device that works according to the guidelines of the Medical-Individual model. This article intends to present the tactics of counter-conduct as ways of subjectivation that resist current governmentality, becoming the visibilization of such actions, a key aspect of any strategy of political transformation.

  3. Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns.

    Science.gov (United States)

    Williamson, Deborah A; Carter, Glen P; Howden, Benjamin P

    2017-07-01

    Bacterial skin infections represent some of the most common infectious diseases globally. Prevention and treatment of skin infections can involve application of a topical antimicrobial, which may be an antibiotic (such as mupirocin or fusidic acid) or an antiseptic (such as chlorhexidine or alcohol). However, there is limited evidence to support the widespread prophylactic or therapeutic use of topical agents. Challenges involved in the use of topical antimicrobials include increasing rates of bacterial resistance, local hypersensitivity reactions (particularly to older agents, such as bacitracin), and concerns about the indiscriminate use of antiseptics potentially coselecting for antibiotic resistance. We review the evidence for the major clinical uses of topical antibiotics and antiseptics. In addition, we review the mechanisms of action of common topical agents and define the clinical and molecular epidemiology of antimicrobial resistance in these agents. Moreover, we review the potential use of newer and emerging agents, such as retapamulin and ebselen, and discuss the role of antiseptic agents in preventing bacterial skin infections. A comprehensive understanding of the clinical efficacy and drivers of resistance to topical agents will inform the optimal use of these agents to preserve their activity in the future. Copyright © 2017 American Society for Microbiology.

  4. 77 FR 58143 - Interagency Task Force on Antimicrobial Resistance (ITFAR): An Update of A Public Health Action...

    Science.gov (United States)

    2012-09-19

    ...-2012-0011] Interagency Task Force on Antimicrobial Resistance (ITFAR): An Update of A Public Health...), Department of Health and Human Services (HHS). ACTION: Notice of public meeting and request for comments... Federal agencies in accomplishing activities outlined in ``A Public Health Action Plan to Combat...

  5. Colistin in Pig Production: Chemistry, Mechanism of Antibacterial Action, Microbial Resistance Emergence, and One Health Perspectives

    Science.gov (United States)

    Rhouma, Mohamed; Beaudry, Francis; Thériault, William; Letellier, Ann

    2016-01-01

    , veterinarians, and other scientific health and environmental professionals. This review is an update on the chemistry of colistin, its applications and antibacterial mechanism of action, and on Enterobacteriaceae resistance to colistin in pigs. We also detail and discuss the One Health approach and propose guidelines for colistin resistance management. PMID:27891118

  6. Colistin in pig production: Chemistry, Mechanism of antibacterial action, Microbial resistance emergence, and One Health Perspectives

    Directory of Open Access Journals (Sweden)

    Mohamed Rhouma

    2016-11-01

    cooperation between physicians, veterinarians, and other scientific health and environmental professionals. This review is an update on the chemistry of colistin, its applications and antibacterial mechanism of action, and on Enterobacteriaceae resistance to colistin in pigs. We also detail and discuss the One Health approach and propose guidelines for colistin resistance management.

  7. Modes of Action, Resistance and Toxicity of Insecticides Targeting Nicotinic Acetylcholine Receptors.

    Science.gov (United States)

    Ihara, Makoto; Buckingham, Steven D; Matsuda, Kazuhiko; Sattelle, David B

    2017-01-01

    Nicotinic acetylcholine receptors (nAChRs) of insects play a key role in fast excitatory neurotransmission. Several classes of insecticides target insect nAChRs, which are composed of subunit members of a family of multiple subunit encoding genes. Alternative splicing and RNA A-to-I editing can add further to receptor diversity. Native and recombinant receptors have been explored as sites of insecticide action using radioligands, electrophysiology and site-directed mutagenesis. We have reviewed the properties of native and recombinant insect nAChRs, the challenges of functional recombinant insect nAChR expression, nAChR interactions with ligands acting at orthosteric and allosteric sites and in particular their interactions with insecticides. Actions on insect nAChRs of cartap, neonicotinoids, spinosyns, sulfoxamines, butenolides and mesoionic insecticides are reviewed and current knowledge of their modes of action are addressed. Mutations that add to our understanding of insecticide action and those leading to resistance are discussed. Co-crystallisation of neonicotinoids with the acetylcholine binding protein (AChBP), a surrogate for the nAChR ligand binding domain, has proved instructive. Toxicity issues relating to insecticides targeting nAChRs are also considered. An overview of insecticide classes targeting insect nAChRs has enhanced our understanding of these important receptors and their insecticide binding sites. However, the subunit composition of native nAChRs remains poorly understood and functional expression still presents difficulties. These topics together with improved understanding of the precise sites of insecticide actions on insect nAChRs will be the subject of future research. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  8. Auxinic herbicides, mechanisms of action, and weed resistance: A look into recent plant science advances

    Directory of Open Access Journals (Sweden)

    Pedro Jacob Christoffoleti

    2015-08-01

    Full Text Available Auxin governs dynamic cellular processes involved at several stages of plant growth and development. In this review, we discuss the mechanisms employed by auxin in light of recent scientific advances, with a focus on synthetic auxins as herbicides and synthetic auxin resistance mechanisms. Two auxin receptors were reported. The plasma membrane receptor ABP1 (Auxin Binding Protein 1 alters the structure and arrangement of actin filaments and microtubules, leading to plant epinasty and reducing peroxisomes and mitochondria mobility in the cell environment. The second auxin receptor is the gene transcription pathway regulated by the SCFTir/AFB ubiquitination complex, which destroys transcription repressor proteins that interrupt Auxin Response Factor (ARF activation. As a result mRNA related with Abscisic Acid (ABA and ethylene are transcribed, producing high quantities of theses hormones. Their associated action leads to high production of Reactive Oxygen Species (ROS, leading to tissue and plant death. Recently, another ubiquitination pathway which is described as a new auxin signaling route is the F-box protein S-Phase Kinase-Associated Protein 2A (SKP2A. It is active in cell division regulation and there is evidence that auxin herbicides can deregulate the SKP2A pathway, which leads to severe defects in plant development. In this discussion, we propose that SFCSKP2A auxin binding site alteration could be a new auxinic herbicide resistance mechanism, a concept which may contribute to the current progress in plant biology in its quest to clarify the many questions that still surround auxin herbicide mechanisms of action and the mechanisms of weed resistance.

  9. THE ROLE OF THE COMMITTEE OF THE REGIONS IN THE IMPLEMENTATION OF "EUROPE 2020": MECHANISMS, ACTIONS, PROSPECTS

    Directory of Open Access Journals (Sweden)

    Adrian-Gabriel CORPADEAN

    2015-10-01

    Full Text Available This article examines the institutional tools and mechanisms that the Committee of the Regions in endowed with, in the process of implementing and checking the progress of the Europe 2020 Agenda. The emphasis first lies on the traditional consultative nature of the aforementioned body, which has nevertheless been striving for more prominence. The previous role in the evaluation of the Lisbon Strategy has provided the CoR with some experience, to the extent that the Monitoring Platform it is utilising in its activities pertaining to Europe 2020 are coherent and quite complex. We have performed an analysis of the current activities conducted by the CoR under the auspices of the Platform, including text analyses on its latest releases and assessments of its consultation and networking activities. Some recommendations have been filed to enhance the subnational dimension of the Europe 2020 Agenda, in the light of the findings of CoR panels.

  10. The resistance of surfaces treated with oils and waxes to the action of dry heat

    Directory of Open Access Journals (Sweden)

    Jaić Milan

    2009-01-01

    Full Text Available Surface treatment of wood can be done with different coatings, and the choice of the appropriate system of processing depends on several factors, such as technological, aesthetic, economic and ecological. Raising awareness of the need to preserve the living and working environment has had a crucial impact on the increase in the use of natural materials for surface treatment of wood - oil and wax. The application of oils and waxes allows surface treated wood to keep the natural look, while protecting it from different influences, which can cause degradation and deterioration of the final product. The paper presents the results of testing the resistance of beech surface (Fagus silvatica L. processed with linseed oil and beeswax to the action of dry heat. In order to compare the quality of surface treated with oil and/or wax, beech wood treated with 2K-polyurethane coating is taken as a reference of surface treatment of wood. Surfaces treated with beeswax are less resistant to dry heat than those treated with linseed oil, and both showed significantly less resistance than surface treated with 2K-polyurethane coating.

  11. Role of resveratrol in the management of insulin resistance and related conditions: Mechanism of action.

    Science.gov (United States)

    Abbasi Oshaghi, Ebrahim; Goodarzi, Mohammad Taghi; Higgins, Victoria; Adeli, Khosrow

    2017-06-01

    Resveratrol (RES), a well-known antioxidant, is present in numerous plant species and, as a result, is easily obtained through dietary intake of plant-based foods and beverages. Several studies suggest that RES has anti-carcinogenic, anti-microbial, and anti-viral effects. It may also have beneficial metabolic properties that result in mitigation of insulin resistance (IR) and related metabolic abnormalities, including dyslipidemia, hyperglycemia, and hyperinsulinemia through regulation of gene expression or the activity of rate-limiting enzymes. A large body of evidence supports the beneficial effects of RES in the management and treatment of IR, type 2 diabetes, and related complications through a multitude of mechanisms. This review article focuses on the mechanisms of action of RES, the mechanisms leading to improved insulin sensitivity, and its clinical role in the management and treatment of type 2 diabetes.

  12. The synergy and mode of action of quercetin plus amoxicillin against amoxicillin-resistant Staphylococcus epidermidis.

    Science.gov (United States)

    Siriwong, Supatcharee; Teethaisong, Yothin; Thumanu, Kanjana; Dunkhunthod, Benjawan; Eumkeb, Griangsak

    2016-08-04

    Staphylococcus epidermidis is one of the most multiple resistances to antibiotics in the recent years. Therefore, practically-prescribed antibiotics in the treatment of these strains are not effective. Plant-derived antibacterial is one of the most interesting sources of new therapeutics. The present study was to investigate antibacterial, synergy and modes of action of quercetin and amoxicillin against amoxicillin-resistant Staphylococcus epidermidis (ARSE). The MICs, checkerboard assay, viability curves, cytoplasmic membrane (CM) permeability, enzyme assay, transmission electron microscopy, confocal microscopy and FT-IR microspectroscopy measurement was performed. The MICs of amoxicillin, penicillin, quercetin and kaempferol against all ARSE strains were 16, 200, 256-384 and >1024 μg/mL respectively. Synergistic effects were exhibited on amoxicillin plus quercetin and penicillin plus kaempferol against these strains at FIC index 0.50 and amoxicillin was confirmed by the viable count. This combination increased CM permeability, caused marked morphological, peptidoglycan and cytoplasmic membrane damage, increased protein amide I and II, but decreased fatty acid in bacterial cells. The quercetin had an inhibitory activity against β-lactamase. So, these findings are the first report that quercetin has the synergistic effect with amoxicillin against ARSE via four modes of actions, inhibit peptidoglycan synthesis and β-lactamases activity, increase CM permeability and protein amide I and II but decrease fatty acid in bacterial cells. Of course, this flavonol has the dominant potential to develop a brand-new collateral phytochemical agent plus amoxicillin to treat ARSE. Future work should focus on the bioavailability, efficacy and toxicity in animal and human studies, as well as, the synergistic effect on blood and tissue should be evaluated and achieved.

  13. Telavancin: mechanisms of action, in vitro activity, and mechanisms of resistance.

    Science.gov (United States)

    Karlowsky, James A; Nichol, Kim; Zhanel, George G

    2015-09-15

    Telavancin is a semisynthetic lipoglycopeptide derivative of vancomycin. Telavancin has a dual mechanism of antibacterial action, disrupting peptidoglycan synthesis and cell membrane function. In 2014, the Clinical and Laboratory Standards Institute (CLSI) revised the antimicrobial susceptibility testing method for telavancin, resulting in minimum inhibitory concentration (MIC) determinations that are more accurate and reproducible and demonstrate greater in vitro potency than shown with the previous testing method. The CLSI testing method changes coincided with revised telavancin MIC interpretive break point criteria for susceptibility approved by the US Food and Drug Administration for Staphylococcus aureus (≤0.12 µg/mL), Streptococcus pyogenes (≤0.12 µg/mL), Streptococcus agalactiae (≤0.12 µg/mL), Streptococcus anginosus group (≤0.06 µg/mL), and Enterococcus faecalis (vancomycin susceptible, ≤0.25 µg/mL). Telavancin is equally potent against methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). It demonstrates activity against isolates of heterogeneous vancomycin-intermediate S. aureus and vancomycin-intermediate S. aureus but is poorly active against vancomycin-resistant S. aureus. It also demonstrates potent activity against Staphylococcus epidermidis and Streptococcus spp. (MIC90 ≤0.03 µg/mL). Thus far, it has not been possible to select for high-level telavancin resistance in the laboratory using serially passaged clinical isolates of MRSA and MSSA. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  14. 76 FR 56454 - Consumer Advisory Committee Meeting

    Science.gov (United States)

    2011-09-13

    ... COMMISSION Consumer Advisory Committee Meeting AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (Committee). The purpose of the Committee is to make recommendations to the Commission regarding consumer...

  15. Conjugation of platinum(IV) complexes with chlorambucil to overcome cisplatin resistance via a "joint action" mode toward DNA.

    Science.gov (United States)

    Qin, Xiaodong; Fang, Lei; Chen, Feihong; Gou, Shaohua

    2017-09-08

    Two platinum(IV) complexes were designed and prepared by conjugation of cisplatin and oxaliplatin units with a DNA-damaging agent, chlorambucil, respectively. By taking a joint action to enhance the damage of DNA, the conjugates displayed potent antitumor activity against all the tested cancer cell lines comparable to cisplatin and oxaliplatin, and notably could overcome cisplatin resistance at certain degree. Complex 4, a hybrid of cisplatin and chlorambucil, arrested the cell cycle at the S and G2 phases, distinctive from those of cisplatin and oxaliplatin. Apoptosis studies revealed that complex 4 could induce cell apoptosis significantly in both SGC7901 and SGC7901/CDDP cells. Moreover, further investigation indicated that complex 4 suppressed the drug resistance by the improvement of the platinum uptake and the inhibition of PRAP-1 protein. These results show that the "joint action" on DNA is an effective strategy to overcome cisplatin resistance. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  16. Evaluating an Action Threshold-Based Insecticide Program on Onion Cultivars Varying in Resistance to Onion Thrips (Thysanoptera: Thripidae).

    Science.gov (United States)

    Nault, Brian A; Huseth, Anders S

    2016-08-01

    Onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae), is a highly destructive pest of onion, Allium cepa L., and its management relies on multiple applications of foliar insecticides. Development of insecticide resistance is common in T. tabaci populations, and new strategies are needed to relax existing levels of insecticide use, but still provide protection against T. tabaci without compromising marketable onion yield. An action threshold-based insecticide program combined with or without a thrips-resistant onion cultivar was investigated as an improved approach for managing T. tabaci infestations in commercial onion fields. Regardless of cultivar type, the average number of insecticide applications needed to manage T. tabaci infestations in the action-threshold based program was 4.3, while the average number of sprays in the standard weekly program was 7.2 (a 40% reduction). The mean percent reduction in numbers of applications following the action threshold treatment in the thrips-resistant onion cultivar, 'Advantage', was 46.7% (range 40-50%) compared with the standard program, whereas the percentage reduction in applications in action threshold treatments in the thrips-susceptible onion cultivar, 'Santana', was 34.3% (range 13-50%) compared with the standard program, suggesting a benefit of the thrips-resistant cultivar. Marketable bulb yields for both 'Advantage' and 'Santana' in the action threshold-based program were nearly identical to those in the standard program, indicating that commercially acceptable bulb yields will be generated with fewer insecticide sprays following an action threshold-based program, saving money, time and benefiting the environment. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  17. Mussel-inspired superhydrophobic surfaces with enhanced corrosion resistance and dual-action antibacterial properties.

    Science.gov (United States)

    Qian, Hongchang; Li, Minglu; Li, Zhong; Lou, Yuntian; Huang, Luyao; Zhang, Dawei; Xu, Dake; Du, Cuiwei; Lu, Lin; Gao, Jin

    2017-11-01

    In this study, a multilayer antibacterial film was assembled onto 316L stainless steel via mussel-inspired depositions of polydopamine (PDA) and silver (Ag) nanoparticles followed by post-modification with 1H, 1H, 2H, 2H-perfluorodecanethiol. The resulting surface exhibited excellent superhydrophobicity with hierarchical micro/nanostructures that were constructed by both PDA and Ag nanoparticles. The crystal structure and chemical composition of these surfaces were investigated using X-ray photoelectron spectroscopy (XPS) analysis. Potentiodynamic polarization measurements revealed that the corrosion resistance of the as-prepared surfaces were sequentially increased after each step of the fabrication process. Compared with the surface covered with only Ag nanoparticles, the superhydrophobic surfaces exhibited substantially enhanced antibacterial activity against the Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, resulting from the synergistic antibacterial actions of the superhydrophobic surface and Ag nanoparticles. The superhydrophobic surface exhibited lower cytotoxicity, compared to the surface covered with Ag nanoparticles. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Riboflavin analogs as antiinfectives: occurrence, mode of action, metabolism and resistance.

    Science.gov (United States)

    Pedrolli, Danielle Biscaro; Jankowitsch, Frank; Schwarz, Julia; Langer, Simone; Nakanishi, Shinobu; Frei, Eva; Mack, Matthias

    2013-01-01

    Antimetabolites are molecules, which are structurally similar to molecules needed to carry out primary metabolic reactions.The inhibitory activity of an antimetabolite depends on its successful competition with the natural substrate, ligand, modulator or cofactor of a given biomolecule. Antimetabolites are indispensable as molecular tools in order to understand biological processes. Beyond that,antimetabolites have a large variety of applications in the pharmaceutical and food industries. The identification of the structural riboflavin(vitamin B2) analog roseoflavin in Streptomyces davawensis demonstrates that anti-vitamins/cofactor analogs may serve as lead structures for the development of novel antibiotics. The latter is supported by the recent finding that roseoflavin had a profound inhibiting effect on the growth and infectivity of the human bacterial pathogen Listeria monocytogenes at very low concentrations. Roseoflavin is studied in our laboratory as a model compound. We investigate the biosynthesis, the possible large-scale production, the metabolization,the mechanism of action and the resistance mechanism of the producer organism in order to pave the way for the structured analysis of other vitamin analogs yet to be discovered. These compounds hopefully will help to replenish the arsenal of antimicrobials urgently needed to fight multiresistant bacterial pathogens.

  19. 77 FR 5494 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2012-02-03

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  20. 75 FR 7234 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2010-02-18

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  1. 75 FR 38779 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2010-07-06

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  2. 77 FR 48968 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2012-08-15

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  3. 75 FR 75968 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2010-12-07

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  4. 75 FR 21602 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2010-04-26

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  5. 78 FR 7758 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2013-02-04

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  6. 77 FR 25145 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2012-04-27

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  7. 75 FR 64699 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2010-10-20

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  8. 77 FR 35941 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2012-06-15

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  9. 76 FR 23796 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2011-04-28

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  10. 78 FR 35260 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2013-06-12

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  11. 76 FR 61672 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2011-10-05

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  12. 77 FR 69597 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2012-11-20

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  13. 78 FR 23541 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2013-04-19

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  14. 76 FR 38638 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2011-07-01

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  15. 78 FR 49260 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2013-08-13

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee). The Committee provides...

  16. 77 FR 6813 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2012-02-09

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Security Telecommunications Advisory Committee (NSTAC) will meet on Tuesday, February 28, 2012, via a... related to national security and emergency preparedness telecommunications policy. During the conference...

  17. 77 FR 75182 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2012-12-19

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Security Telecommunications Advisory Committee (NSTAC) will meet on Friday, January 11, 2013, via... related to national security and emergency preparedness telecommunications policy. Agenda: The NSTAC...

  18. 76 FR 52672 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2011-08-23

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Security Telecommunications Advisory Committee (NSTAC) will meet on Thursday, September 8, 2011, via a... related to national security and emergency preparedness telecommunications policy. During the conference...

  19. 77 FR 10798 - Aviation Rulemaking Advisory Committee

    Science.gov (United States)

    2012-02-23

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Aviation Rulemaking Advisory Committee AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of withdrawal of task assignment to the Aviation Rulemaking Advisory Committee (ARAC). SUMMARY: The FAA has withdrawn a task...

  20. 78 FR 54680 - NASA Federal Advisory Committees

    Science.gov (United States)

    2013-09-05

    ... Committee Management Division, Office of International and Interagency Relations, NASA Headquarters... AGENCY: National Aeronautics and Space Administration. ACTION: Annual Invitation for Public Nominations... invitation for public nominations for service on NASA Federal advisory committees. U.S. citizens may nominate...

  1. 76 FR 3633 - Consumer Advisory Committee

    Science.gov (United States)

    2011-01-20

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: This document announces the rechartering of the Consumer Advisory Committee (hereinafter ``the... ``Commission'') regarding consumer issues within the jurisdiction of the Commission and to facilitate the...

  2. Potent proapoptotic actions of dihydroartemisinin in gemcitabine-resistant A549 cells.

    Science.gov (United States)

    Zhao, Chubiao; Qin, Guiqi; Gao, Weijie; Chen, Jingqin; Liu, Hongyu; Xi, Gaina; Li, Tan; Wu, Shengnan; Chen, Tongsheng

    2014-10-01

    Our recent studies have demonstrated the key roles of reactive oxygen species (ROS)-mediated caspase-8- and Bax-dependent apoptotic pathways in dihydroartemisinin (DHA)-induced apoptosis of A549 cells. This report is designed to investigate the proapoptotic mechanisms of DHA in gemcitabine (Gem)-resistant A549 (A549GR) cells. A549GR cells exhibited lower basal antioxidant capacity, higher level of basal ROS and intracellular Fe(2+) than Gem-sensitive A549 (A549) cells. In contrast to the sluggish ROS generation induced by Gem, DHA induced a rapid ROS generation within 30min. Moreover, Gem induced similar ROS generation in both cell lines, while DHA induced more ROS generation in A549GR cells than in A549 cells. More importantly, after treatment with DHA, A549GR cells showed more potent induction in Bax activation, loss of mitochondrial membrane potential (ΔΨm), caspase activation and apoptosis than A549 cells. Furthermore, NAC pretreatment potently prevented DHA-induced ROS generation and loss of ΔΨm as well as apoptosis, and silencing Bax by shRNA or inhibition of one of caspase-3, -8 and -9 also significantly prevented DHA-induced apoptosis in both cell lines, indicating the key roles of ROS and Bax as well as the caspases. Collectively, DHA presents more potent proapoptotic actions in A549GR cells preferentially over normal A549 cells via ROS-dependent apoptotic pathway, in which Bax and caspases are involved. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Bacillus thuringiensis: mechanism of action, resistance, and new applications: a review.

    Science.gov (United States)

    Melo, André Luiz de Almeida; Soccol, Vanete Thomaz; Soccol, Carlos Ricardo

    2016-01-01

    Since the first report by Ishiwata in 1902 of a Bombyx mori infection, followed by the description by Berliner, Bacillus thuringiensis (Bt) has become the main microorganism used in biological control. The application of Bt to combat invertebrates of human interest gained momentum with the growing demand for food free of chemical pesticides and with the implementation of agriculture methods that were less damaging to the environment. However, the mechanisms of action of these products have not been fully elucidated. There are two proposed models: the first is that Bt causes an osmotic imbalance in response to the formation of pores in a cell membrane, and the second is that it causes an opening of ion channels that activate the process of cell death. There are various ways in which Bt resistance can develop: changes in the receptors that do not recognize the Cry toxin, the synthesis of membrane transporters that eliminate the peptides from the cytosol and the development of regulatory mechanisms that disrupt the production of toxin receptors. Besides the potential for formulation of biopesticides and the use in developing genetically modified cultivars, recent studies with Bt have discussed promising applications in other branches of science. Chitinase, an enzyme that degrades chitin, increases the efficiency of Bt insecticides, and there has been of increasing interest in the industry, given that its substrate is extremely abundant in nature. Another promising field is the potential for Bt proteins to act against cancer cells. Parasporins, toxins of Bt that do not have an entomopathogenic effect, have a cytotoxic effect on the cells changed by some cancers. This demonstrates the potential of the microorganism and new opportunities opening for future applications.

  4. Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs.

    Science.gov (United States)

    Soares, Geisla Mary Silva; Figueiredo, Luciene Cristina; Faveri, Marcelo; Cortelli, Sheila Cavalca; Duarte, Poliana Mendes; Feres, Magda

    2012-01-01

    Antibiotics are important adjuncts in the treatment of infectious diseases, including periodontitis. The most severe criticisms to the indiscriminate use of these drugs are their side effects and, especially, the development of bacterial resistance. The knowledge of the biological mechanisms involved with the antibiotic usage would help the medical and dental communities to overcome these two problems. Therefore, the aim of this manuscript was to review the mechanisms of action of the antibiotics most commonly used in the periodontal treatment (i.e. penicillin, tetracycline, macrolide and metronidazole) and the main mechanisms of bacterial resistance to these drugs. Antimicrobial resistance can be classified into three groups: intrinsic, mutational and acquired. Penicillin, tetracycline and erythromycin are broad-spectrum drugs, effective against gram-positive and gram-negative microorganisms. Bacterial resistance to penicillin may occur due to diminished permeability of the bacterial cell to the antibiotic; alteration of the penicillin-binding proteins, or production of β-lactamases. However, a very small proportion of the subgingival microbiota is resistant to penicillins. Bacteria become resistant to tetracyclines or macrolides by limiting their access to the cell, by altering the ribosome in order to prevent effective binding of the drug, or by producing tetracycline/macrolide-inactivating enzymes. Periodontal pathogens may become resistant to these drugs. Finally, metronidazole can be considered a prodrug in the sense that it requires metabolic activation by strict anaerobe microorganisms. Acquired resistance to this drug has rarely been reported. Due to these low rates of resistance and to its high activity against the gram-negative anaerobic bacterial species, metronidazole is a promising drug for treating periodontal infections.

  5. Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs

    Directory of Open Access Journals (Sweden)

    Geisla Mary Silva Soares

    2012-06-01

    Full Text Available Antibiotics are important adjuncts in the treatment of infectious diseases, including periodontitis. The most severe criticisms to the indiscriminate use of these drugs are their side effects and, especially, the development of bacterial resistance. The knowledge of the biological mechanisms involved with the antibiotic usage would help the medical and dental communities to overcome these two problems. Therefore, the aim of this manuscript was to review the mechanisms of action of the antibiotics most commonly used in the periodontal treatment (i.e. penicillin, tetracycline, macrolide and metronidazole and the main mechanisms of bacterial resistance to these drugs. Antimicrobial resistance can be classified into three groups: intrinsic, mutational and acquired. Penicillin, tetracycline and erythromycin are broad-spectrum drugs, effective against gram-positive and gram-negative microorganisms. Bacterial resistance to penicillin may occur due to diminished permeability of the bacterial cell to the antibiotic; alteration of the penicillin-binding proteins, or production of β-lactamases. However, a very small proportion of the subgingival microbiota is resistant to penicillins. Bacteria become resistant to tetracyclines or macrolides by limiting their access to the cell, by altering the ribosome in order to prevent effective binding of the drug, or by producing tetracycline/macrolide-inactivating enzymes. Periodontal pathogens may become resistant to these drugs. Finally, metronidazole can be considered a prodrug in the sense that it requires metabolic activation by strict anaerobe microorganisms. Acquired resistance to this drug has rarely been reported. Due to these low rates of resistance and to its high activity against the gram-negative anaerobic bacterial species, metronidazole is a promising drug for treating periodontal infections.

  6. 78 FR 69991 - Advisory Committee; Veterinary Medicine Advisory Committee; Termination

    Science.gov (United States)

    2013-11-22

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 14 Advisory Committee; Veterinary Medicine Advisory Committee; Termination AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is announcing the termination of the Veterinary Medicine Advisory...

  7. The Power of Student Resistance in Action Research: Teacher Educators Respond to Classroom Challenges

    Science.gov (United States)

    Bryant, Jill; Bates, Alisa

    2010-01-01

    The purpose of this research was to study the design and implementation of a newly developed, two-semester, action research course in a Master of Arts in Teaching program. Over a four-year period, we (the instructors) used action research methodologies for analysis and evaluation of the course. Throughout this study, students expressed varying…

  8. AGU Committees

    Science.gov (United States)

    Administrative Committees are responsible for those functions required for the overall performance or well-being of AGU as an organization. These committees are Audit and Legal Affairs, Budget and Finance*, Development, Nominations*, Planning, Statutes and Bylaws*, Tellers.Operating Committees are responsible for the policy direction and operational oversight of AGU's primary programs. The Operating Committees are Education and Human Resources, Fellows*, Information Technology, International Participation*, Meetings, Public Affairs, Public Information, Publications*.

  9. Critical Leadership for Education in a Postmodern World: Emancipation, Resistance and Communal Action.

    Science.gov (United States)

    Ryan, James

    1998-01-01

    Explores possibilities for critical, resistance-based approaches to school leadership. Compares Marx's, Habermas's, Baudrillard's, and Foucault's views of human regulation, along with other individual/group theories. Assesses theories' utility for critical leadership in education. Individuals can resist oppressive school practices by pursuing…

  10. Youth Participatory Action Research: A Pedagogy of Transformational Resistance for Critical Youth Studies

    Science.gov (United States)

    Cammarota, Julio

    2017-01-01

    This article explains how some youth gain insights into educational processes of social reproduction by participating in a pedagogy of transformational resistance. These insights lead to resistances that have the potential to transform young people's subjectivities while allowing them to envision ways of learning to counteract oppressive and…

  11. 76 FR 64122 - NASA Advisory Committee; Renewal of NASA's International Space Station Advisory Committee Charter

    Science.gov (United States)

    2011-10-17

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-095)] NASA Advisory Committee; Renewal of NASA's International Space Station Advisory Committee Charter AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of renewal and amendment of the Charter of the International...

  12. Mechanism of Action of Substituted Indanones in Multidrug Resistant Breast Cancer

    National Research Council Canada - National Science Library

    Leoni, Lorenzo

    2001-01-01

    ... (Cancer Res 2001 Oct 1;61(19):7248.54) - analyzed the indanocine-resistant stable cell line - identified the potential indanocine-binding site on tubulin - continued the animal testing of indanocine - studies the pro-apoptotic mechanism...

  13. 76 FR 79151 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2011-12-21

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Forest Resource Committee Meeting will meet in Washington, DC on January 20, 2012... closed to the public. The Forest Resource Committee is authorized under the Food, Conservation, and...

  14. 78 FR 34035 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-06-06

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Forest Resource Coordinating Committee will meet via teleconference every month on... conference call will be posted to the Forest Resource Coordinating Committee Web site, http://www.fs.fed.us...

  15. 78 FR 26337 - Methane Hydrate Advisory Committee

    Science.gov (United States)

    2013-05-06

    ... DEPARTMENT OF ENERGY Methane Hydrate Advisory Committee AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Methane.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Methane Hydrate Advisory Committee is to...

  16. 75 FR 9886 - Methane Hydrate Advisory Committee

    Science.gov (United States)

    2010-03-04

    ... DEPARTMENT OF ENERGY Methane Hydrate Advisory Committee AGENCY: Department of Energy, Office of Fossil Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Methane... the Committee: The purpose of the Methane Hydrate Advisory Committee is to provide advice on potential...

  17. 78 FR 37536 - Methane Hydrate Advisory Committee

    Science.gov (United States)

    2013-06-21

    ... DEPARTMENT OF ENERGY Methane Hydrate Advisory Committee AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Methane... Committee: The purpose of the Methane Hydrate Advisory Committee is to provide advice on potential...

  18. 76 FR 13996 - Advisory Committee Meeting Notice

    Science.gov (United States)

    2011-03-15

    ... Department of the Army Advisory Committee Meeting Notice AGENCY: Department of the Army, DOD. ACTION: Notice of meeting. SUMMARY: Pursuant to the Federal Advisory Committee Act of 1972 (5 U.S.C., Appendix, as... provisional findings for referral to the Army Education Advisory Committee will follow on 6 April beginning at...

  19. 75 FR 7255 - Advisory Committee Meeting Notice

    Science.gov (United States)

    2010-02-18

    ... Department of the Army Advisory Committee Meeting Notice AGENCY: Department of the Army, DOD. ACTION: Notice of meeting. SUMMARY: Pursuant to the Federal Advisory Committee Act of 1972 (5 U.S.C., Appendix, as... findings for referral to the Army Education Advisory Committee will follow on 10 March beginning at about...

  20. Determination of the resistance of fabric printed with triclosan microcapsules to the action of soil micro-flora

    Science.gov (United States)

    Golja, B.; Forte Tavčer, P.

    2017-10-01

    Microcapsules with a pressure-sensitive melamine-formaldehyde wall and triclosan core were printed to 100% cotton fabric with screen printing technique. Previous research showed excellent antibacterial activity (estimated for E. Coli and S. Aureus) of such fabric, so our aim in this research was to determine its resistance to the action of microorganisms present in the soil. The soil burial test was conducted. The breaking strength of the buried samples was measured and also the scanning electron microscope analysis was done. The results showed that none of the samples are resistant to decay. It is evident from SEM micrographs that on all of the buried samples greater morphological changes occur due to the functions of the soil microflora. It can be concluded that the samples printed with triclosan microcapsules are biodegradable which is environmentally preferable.

  1. Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives.

    Science.gov (United States)

    Huang, Li; Yuan, Xiong; Yu, Donglei; Lee, K H; Chen, Chin Ho

    2005-02-20

    Dicamphanoyl khellactone (DCK) is a coumarin derivative that can potently inhibit HIV-1 replication. DCK does not inhibit RNA-dependent DNA synthesis. However, an HIV reverse transcriptase (RT) inhibitor-resistant strain, HIV-1/RTMDR1, is resistant to DCK. Thus, it is possible that HIV-1 RT is the target of DCK. To test this possibility, DCK-resistant viruses were selected in the presence of DCK. Our results indicate that a single amino acid mutation, E138K in HIV-1 RT, is sufficient to confer DCK resistance. Interestingly, a DCK derivative, 3'R,4'R-Di-O-(-)-camphanoyl-2-ethyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP8), is effective against HIV-1/RTMDR1. However, the DCK-escape virus carrying the E138K mutation remains resistant to DCP8. Since DCK did not inhibit the RNA-dependent DNA polymerase activity of HIV-1 RT when using poly-rA or poly-rC as template, we evaluated the effect of DCK on the DNA-dependent DNA polymerase activity of HIV-1 RT. Our results indicate that DCK can inhibit the DNA-dependent DNA polymerase activity of HIV-1 RT. In conclusion, DCK is a unique HIV-1 RT inhibitor that inhibits the DNA-dependent DNA polymerase activity. In contrast, DCK did not significantly affect the RNA-dependent DNA polymerase activity when poly-rA or poly-rC was used as templates. An E138K mutation in the non-nucleoside RT inhibitors (NNRTIs) binding pocket of HIV-1 RT confers resistance to DCK and its chromone derivative, DCP8.

  2. Exploring the Molecular Mechanisms of Glucocorticoid Receptor Action from Sensitivity to Resistance

    OpenAIRE

    Ramamoorthy, Sivapriya; Cidlowski, John A.

    2013-01-01

    Glucocorticoids regulate a variety of physiological processes, and are commonly used to treat disorders of inflammation, autoimmune diseases, and cancer. Glucocorticoid action is predominantly mediated through the classic glucocorticoid receptor (GR), but sensitivity to glucocorticoids varies among individuals, and even within different tissues from the same individual. The molecular basis of this phenomenon can be partially explained through understanding the process of generating bioavailab...

  3. Mechanism of Action of Substituted Indanones in Multidrug Resistant Breast Cancer

    National Research Council Canada - National Science Library

    Leoni, Lorenzo

    2002-01-01

    ... (Cancer Res 2001 Oct 1 61(1 9):7248-54) - analyzed the indanocine-resistant stable cell line - identified the potential indanocine-binding site on tubulin - continued the animal testing of indanocine - studies the pro-apoptotic mechanism...

  4. Transformational change towards gender equality: An autobiographical reflection on resistance during participatory action research

    NARCIS (Netherlands)

    Bleijenbergh, I.L.

    2018-01-01

    This article contributes to the academic debate about gender equality change by conceptualizing resistance to gender equality change as characteristic of a system where gendered organizations tend to move back to an equilibrium when confronted with change. It explores the role of change agents and

  5. The dynamics of resistance to change: A sequential analysis of change agents in action

    NARCIS (Netherlands)

    Klonek, F.E.; Lehmann-Willenbrock, N.K.; Kauffeld, S.

    2014-01-01

    Despite consensus that successful change management depends on how change is communicated to employees, the dynamic communication process between change agents and recipients remains largely unexplored. We discuss how change language can capture recipients' resistance to and readiness for change, in

  6. The mechanism of action of Russian propolis ethanol extracts against two antibiotic-resistant biofilm-forming bacteria.

    Science.gov (United States)

    Bryan, J; Redden, P; Traba, C

    2016-02-01

    The interaction between antibiotic-resistant Staphylococcus aureus and antibiotic-sensitive Escherichia coli biofilm-forming bacteria and Russian propolis ethanol extracts was evaluated. In this study, bacterial cell death occurred when the cell membranes of bacteria interacted specifically with the antibacterial compounds found in propolis. In order to understand the Russian propolis ethanol extract mechanism of action, microscopy and bacterial lysis studies were conducted. Results uncovered from these experiments imply that the mechanism of action of Russian propolis ethanol extracts is structural rather than functional. The results obtained throughout this study demonstrate cell membrane damage, resulting in cell lysis and eventually bacterial death. Most strains of bacteria and subsequently biofilms, have evolved and have altered their chemical composition in an attempt to protect themselves from antibiotics. The resistant nature of bacteria stems from the chemical rather than the physical means of inactivation of antibiotics. The results uncovered in this work demonstrate the potential application of Russian propolis ethanol extracts as a very efficient and effective method for bacterial and biofilm inactivation. © 2015 The Society for Applied Microbiology.

  7. Antibacterial action of doped CoFe{sub 2}O{sub 4} nanocrystals on multidrug resistant bacterial strains

    Energy Technology Data Exchange (ETDEWEB)

    Velho-Pereira, S.; Noronha, A.; Mathias, A.; Zakane, R.; Naik, V.; Naik, P. [Department of Biotechnology, St. Xavier' s College, Goa (India); Salker, A.V. [Department of Chemistry, Goa University, Goa (India); Naik, S.R., E-mail: srnaik19@gmail.com [Department of Chemistry, St. Xavier' s College, Goa (India)

    2015-07-01

    The bactericidal effect of pristine and doped cobalt ferrite nanoparticles has been evaluated against multiple drug resistant clinical strains by assessing the number of colony-forming units (CFU). Monophasic polycrystalline ferrites have been prepared by the malate–glycolate sol–gel autocombustion method as confirmed by the X-ray diffraction study. Various changes occurring during the preparative stages have been demonstrated using TG–DTA analysis which is well complemented by the FTIR spectroscopy. The antibacterial studies carried out demonstrate a bactericidal effect of the nanoparticles wherein the number of CFU has been found to decrease with doping. Cellular distortions have been revealed through SEM. Variation in the number of CFU with dopant type has also been reported herein. - Graphical abstract: Antibacterial action of doped cobalt ferrites resulting in the lyses of multi-drug resistant bacterial strains. - Highlights: • The paper reports an antibacterial study of rare earth doped cobalt ferrite nanoparticles. • Monophasic compounds have been prepared by the sol–gel autocombustion method. • Bactericidal property has been evaluated based on the number of colony forming units. • Variation in bactericidal action with respect to the dopant type has been observed. • Cellular distortions resulting in cell lysis are confirmed from the SEM images.

  8. Supramolecular Cationic Assemblies against Multidrug-Resistant Microorganisms: Activity and Mechanism of Action

    Directory of Open Access Journals (Sweden)

    Letícia Dias de Melo Carrasco

    2015-03-01

    Full Text Available The growing challenge of antimicrobial resistance to antibiotics requires novel synthetic drugs or new formulations for old drugs. Here, cationic nanostructured particles (NPs self-assembled from cationic bilayer fragments and polyelectrolytes are tested against four multidrug-resistant (MDR strains of clinical importance. The non-hemolytic poly(diallyldimethylammonium chloride (PDDA polymer as the outer NP layer shows a remarkable activity against these organisms. The mechanism of cell death involves bacterial membrane lysis as determined from the leakage of inner phosphorylated compounds and possibly disassembly of the NP with the appearance of multilayered fibers made of the NP components and the biopolymers withdrawn from the cell wall. The NPs display broad-spectrum activity against MDR microorganisms, including Gram-negative and Gram-positive bacteria and yeast.

  9. Discourse in Action: Parents' use of medical and social models to resist disability stigma.

    Science.gov (United States)

    Manago, Bianca; Davis, Jenny L; Goar, Carla

    2017-07-01

    For parents of children with disabilities, stigmatization is part of everyday life. To resist the negative social and emotional consequences of stigma, parents both challenge and deflect social devaluations. Challenges work to upend the stigmatizing structure, while deflections maintain the interaction order. We examine how parents of children with disabilities deploy deflections and challenges, and how their stigma resistance strategies combine with available models of disability discourse. Disability discourse falls into two broad categories: medical and social. The medical model emphasizes diagnostic labels and treats impairment as an individual deficit, while the social model centralizes unaccommodating social structures. The social model's activist underpinnings make it a logical frame for parents to use as they challenge disability stigma. In turn, the medical model's focus on individual "improvement" seems to most closely align with stigma deflections. However, the relationship between stigma resistance strategies and models of disability is an empirical question not yet addressed in the literature. In this study, we examine 117 instances of stigmatization from 40 interviews with 43 parents, and document how parents respond. We find that challenges and deflections do not map cleanly onto the social or medical models. Rather, parents invoke medical and social meanings in ways that serve diverse ends, sometimes centralizing a medical label to challenge stigma, and sometimes recognizing disabling social structures, but deflecting stigma nonetheless. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Rat amylin-(8-37) enhances insulin action and alters lipid metabolism in normal and insulin-resistant rats.

    Science.gov (United States)

    Hettiarachchi, M; Chalkley, S; Furler, S M; Choong, Y S; Heller, M; Cooper, G J; Kraegen, E W

    1997-11-01

    To clarify roles of amylin, we investigated metabolic responses to rat amylin-(8-37), a specific amylin antagonist, in normal and insulin-resistant, human growth hormone (hGH)-infused rats. Fasting conscious rats were infused with saline or hGH, each with and without amylin-(8-37) (0.125 mumol/h), over 5.75 h. At 3.75 h, a hyperinsulinemic (100 mU/l) clamp with bolus 2-deoxy-D-[3H]glucose and [14C]glucose was started. hGH infusion led to prompt (2- to 3-fold) basal hyperamylinemia (P hGH-infused rats. Amylin-(8-37) corrected hGH-induced liver insulin resistance, increased basal plasma triglycerides and lowered plasma nonesterified fatty acids in both groups, and reduced muscle triglyceride and total long-chain acyl-CoA content in saline-treated rats (P hGH infusion; 2) amylin-(8-37) increases whole body and muscle insulin sensitivity and consistently reduces basal insulin levels in normal and hGH-induced insulin resistant rats; and 3) amylin-(8-37) elicits a significant alteration of in vivo lipid metabolism. These findings support a role of amylin in modulating insulin action and suggest that this could be mediated by effects on lipid metabolism.

  11. Asian Network for Education in Nuclear Technology (ANENT). Report of the 1. Coordination Committee meeting including the ANENT Terms of Reference and the Action Plan

    International Nuclear Information System (INIS)

    2007-01-01

    It was noted that ANENT activities have started and ANENT is operational. The following conclusions are made: 1. Member States representatives are encouraged to contact IAEA TC through their respective official channels to request support for ANENT as a Regional TC Project; 2. Member States are invited to consider hosting one of the next Coordination Committee meetings; 3. The further ANENT activities should take into account the fact that nuclear energy and nuclear applications play equally important roles in Asia; 4. Nuclear safety plays a very important role and is being addressed through the ANSN. The meeting encouraged that ANSN and ANENT work together for synergistic effects. It was agreed that a representative from MINT would take the role of spokesperson of ANENT until the next Coordination Committee meeting

  12. Members of the Committee | Women in Science | Initiatives | Indian ...

    Indian Academy of Sciences (India)

    Members of the Committee. Rohini M Godbole; Rajinder J Hans-Gill; D. Balasubramanian. Charge of the Committee. The members of the committee were assigned to formulate the terms of reference and to define appropriate action points to be followed for its work. The committee had come up with many initiatives and ...

  13. 76 FR 28443 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2011-05-17

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Security Telecommunications Advisory Committee (NSTAC) will meet on Thursday, June 2, 2011, in Washington...) telecommunications policy. Agenda: The committee will meet in open session to receive briefings on the Federal...

  14. Induction of Hyperalgesia in Pigs through Blocking Low Hydraulic Resistance Channels and Reduction of the Resistance through Acupuncture: A Mechanism of Action of Acupuncture

    Directory of Open Access Journals (Sweden)

    Wei-Bo Zhang

    2013-01-01

    Full Text Available According to the classic theory of Chinese medicine, pain is due to the blockage in meridian channels, and acupuncture was invented to treat pain by “dredging” the channels. To test the theory, a hyperalgesia model was made by injecting hydrogel into low hydraulic resistance channel (LHRC in 12 anaesthetized minipigs. Tail-flick threshold and ear-flick threshold were measured using a thermal radiation dolorimeter, and relative flick threshold (RFT was calculated. Hydraulic resistance (HR was measured with a biological HR measuring instrument on low HR points on LHRC and on control points with higher HR located outside LHRC; readings were recorded before, during, and after acupuncture treatment. RFT decreased after blocking the LRHC and was still significantly decreased 2 days and 4 days afterwards. No significant changes occurred when injecting saline into the same points or injecting gel into points outside the channel. Subsequent acupuncture reduced HR on LRHC along meridians but had no significant effect on sites with higher HR located outside LHRC. One of the mechanisms of action of acupuncture treatment for chronic pain may be that acupuncture affects peripheral tissue by reducing the HR in LHRC along meridians, improving the flow of interstitial fluid and removing algogenic substances and thereby relieving pain.

  15. Induction of Hyperalgesia in Pigs through Blocking Low Hydraulic Resistance Channels and Reduction of the Resistance through Acupuncture: A Mechanism of Action of Acupuncture.

    Science.gov (United States)

    Zhang, Wei-Bo; Xu, Yi-Hui; Tian, Yu-Ying; Li, Hong; Wang, Guang-Jun; Huang, Tao; Jia, Shu-Yong

    2013-01-01

    According to the classic theory of Chinese medicine, pain is due to the blockage in meridian channels, and acupuncture was invented to treat pain by "dredging" the channels. To test the theory, a hyperalgesia model was made by injecting hydrogel into low hydraulic resistance channel (LHRC) in 12 anaesthetized minipigs. Tail-flick threshold and ear-flick threshold were measured using a thermal radiation dolorimeter, and relative flick threshold (RFT) was calculated. Hydraulic resistance (HR) was measured with a biological HR measuring instrument on low HR points on LHRC and on control points with higher HR located outside LHRC; readings were recorded before, during, and after acupuncture treatment. RFT decreased after blocking the LRHC and was still significantly decreased 2 days and 4 days afterwards. No significant changes occurred when injecting saline into the same points or injecting gel into points outside the channel. Subsequent acupuncture reduced HR on LRHC along meridians but had no significant effect on sites with higher HR located outside LHRC. One of the mechanisms of action of acupuncture treatment for chronic pain may be that acupuncture affects peripheral tissue by reducing the HR in LHRC along meridians, improving the flow of interstitial fluid and removing algogenic substances and thereby relieving pain.

  16. Antimicrobial Action of Water-Soluble β-Chitosan against Clinical Multi-Drug Resistant Bacteria

    Directory of Open Access Journals (Sweden)

    Seong-Cheol Park

    2015-04-01

    Full Text Available Recently, the number of patients infected by drug-resistant pathogenic microbes has increased remarkably worldwide, and a number of studies have reported new antibiotics from natural sources. Among them, chitosan, with a high molecular weight and α-conformation, exhibits potent antimicrobial activity, but useful applications as an antibiotic are limited by its cytotoxicity and insolubility at physiological pH. In the present study, the antibacterial activity of low molecular weight water-soluble (LMWS α-chitosan (α1k, α5k, and α10k with molecular masses of 1, 5, and 10 kDa, respectively and β-chitosan (β1k, β5k, and β10k was compared using a range of pathogenic bacteria containing drug-resistant bacteria isolated from patients at different pH. Interestingly, β5k and β10k exhibited potent antibacterial activity, even at pH 7.4, whereas only α10k was effective at pH 7.4. The active target of β-chitosan is the bacterial membrane, where the leakage of calcein is induced in artificial PE/PG vesicles, bacterial mimetic membrane. Moreover, scanning electron microscopy showed that they caused significant morphological changes on the bacterial surfaces. An in vivo study utilizing a bacteria-infected mouse model found that LMWS β-chitosan could be used as a candidate in anti-infective or wound healing therapeutic applications.

  17. Rebelling against the (Insulin Resistance: A Review of the Proposed Insulin-Sensitizing Actions of Soybeans, Chickpeas, and Their Bioactive Compounds

    Directory of Open Access Journals (Sweden)

    Jaime L. Clark

    2018-03-01

    Full Text Available Insulin resistance is a major risk factor for diseases such as type 2 diabetes and metabolic syndrome. Current methods for management of insulin resistance include pharmacological therapies and lifestyle modifications. Several clinical studies have shown that leguminous plants such as soybeans and pulses (dried beans, dried peas, chickpeas, lentils are able to reduce insulin resistance and related type 2 diabetes parameters. However, to date, no one has summarized the evidence supporting a mechanism of action for soybeans and pulses that explains their ability to lower insulin resistance. While it is commonly assumed that the biological activities of soybeans and pulses are due to their antioxidant activities, these bioactive compounds may operate independent of their antioxidant properties and, thus, their ability to potentially improve insulin sensitivity via alternative mechanisms needs to be acknowledged. Based on published studies using in vivo and in vitro models representing insulin resistant states, the proposed mechanisms of action for insulin-sensitizing actions of soybeans, chickpeas, and their bioactive compounds include increasing glucose transporter-4 levels, inhibiting adipogenesis by down-regulating peroxisome proliferator-activated receptor-γ, reducing adiposity, positively affecting adipokines, and increasing short-chain fatty acid-producing bacteria in the gut. Therefore, this review will discuss the current evidence surrounding the proposed mechanisms of action for soybeans and certain pulses, and their bioactive compounds, to effectively reduce insulin resistance.

  18. Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus.

    Science.gov (United States)

    Amin, Muhammad Usman; Khurram, Muhammad; Khattak, Baharullah; Khan, Jafar

    2015-03-12

    To determine the effect of flavonoids in conjunction with antibiotics in methicillin resistant Staphylococcus aureus (MRSA) a study was designed. The flavonoids included Rutin, Morin, Qurecetin while antibiotics included ampicillin, amoxicillin, cefixime, ceftriaxone, vancomycin, methicillin, cephradine, erythromycin, imipenem, sulphamethoxazole/trimethoprim, ciprofloxacin and levolfloxacin. Test antibiotics were mostly found resistant with only Imipenem and Erythromycin found to be sensitive against 100 MRSA clinical isolates and S. aureus (ATCC 43300). The flavonoids were tested alone and also in different combinations with selected antibiotics. Antibiotics and flavonoids sensitivity assays were carried using disk diffusion method. The combinations found to be effective were sifted through MIC assays by broth macro dilution method. Exact MICs were determined using an incremental increase approach. Fractional inhibitory concentration indices (FICI) were determined to evaluate relationship between antibiotics and flavonoids is synergistic or additive. Potassium release was measured to determine the effect of antibiotic-flavonoids combinations on the cytoplasmic membrane of test bacteria. Antibiotic and flavonoids screening assays indicated activity of flavanoids against test bacteria. The inhibitory zones increased when test flavonoids were combined with antibiotics facing resistance. MICs of test antibiotics and flavonoids reduced when they were combined. Quercetin was the most effective flavonoid (MIC 260 μg/ml) while morin + rutin + quercetin combination proved most efficient with MIC of 280 + 280 + 140 μg/ml. Quercetin + morin + rutin with amoxicillin, ampicillin, cephradine, ceftriaxone, imipenem, and methicillin showed synergism, while additive relationship was indicated between morin + rutin and amoxicillin, cephradine, ceftriaxone, imipenem, and methicillin. Quercetin alone had an additive effect with ampicillin, cephradine

  19. Ontology and Resistance: The Constitution of Oneself as a Paradigm of Political Action in the Late Foucault

    Directory of Open Access Journals (Sweden)

    Jorge Ignacio Moreno Heredia

    2018-01-01

    Full Text Available When we think of Michel Foucault’s contribution to the history of contemporary political thought, we don’t usually refer to his investigations, conducted in the eighties, into the ethics of the care of oneself of Greco-Roman Antiquity. Does that research, nevertheless, lack any political meaning or consequence? To answer this question, we must first put forward the terms of what is mainly at stake in those investigations: the possibility to think differently what it means for a subject to be constituted. With them, Foucault seems to have found an experience and a practice of subjectivation that, once its ontological structure becomes clear, also allows us think of a concept of political action as immanent and autonomous subjectivation capable of resisting the modern dispositifs of power.

  20. Ultraviolet action spectra for aerobic and anaerobic inactivation of Escherichia coli strains specifically sensitive and resistant to near ultraviolet radiations

    International Nuclear Information System (INIS)

    Peak, J.G.; Peak, M.J.; Tuveson, R.W.

    1983-01-01

    Action spectra for the lethal effects of ultraviolet light (254-434 nm) irradiation delivered under aerobic or anaerobic conditions to Escherichia coli RT2 (specifically sensitive to near-UV radiation; > 320 nm) and E. coli RT4 (near-UV resistant) were prepared. Negligible oxygen dependence was observed for both strains below about 315 nm. The oxygen enhancement ratio (OER) for RT4 increased above this wavelength to the longest wavelength used, whereas for RT2 there was a greater increase in the OER to a large peak at 365 nm, then a progressive decrease at longer wavelengths. The results are consistent with the possibility that the sensitivity of strain RT2 to near-UV radiation may be due to hyperproduction of photosensitizer, operating via photodynamic type reactions involving excited species of oxygen. (author)

  1. Zinc chelation: a metallothionein 2A's mechanism of action involved in osteosarcoma cell death and chemotherapy resistance.

    Science.gov (United States)

    Habel, N; Hamidouche, Z; Girault, I; Patiño-García, A; Lecanda, F; Marie, P J; Fromigué, O

    2013-10-24

    Osteosarcoma is the most common primary tumor of bone occurring in children and adolescents. The histological response to chemotherapy represents a key clinical factor related to survival. We previously showed that statins exhibit antitumor effects in vitro, inducing apoptotic cell death, reducing cell migration and invasion capacities and strengthening cytotoxic effects in combination with standard drugs. Comparative transcriptomic analysis between control and statin-treated cells revealed strong expression of several genes, including metallothionein (MT) 2A. MT2A overexpression by lentiviral transduction reduced bioavailable zinc levels, an effect associated with reduced osteosarcoma cell viability and enhanced cell differentiation. In contrast, MT2A silencing did not modify cell viability but strongly inhibited expression of osteoblastic markers and differentiation process. MT2A overexpression induced chemoresistance to cytotoxic drugs through direct chelation of platinum-containing drugs and indirect action on p53 zinc-dependent activity. In contrast, abrogation of MT2A enhanced cytotoxic action of chemotherapeutic drugs on osteosarcoma cells. Finally, clinical samples derived from chemonaive biopsies revealed that tumor cells expressing low MT2A levels correspond to good prognostic (good responder patients with longer survival rate), whereas high MT2A levels were associated with adverse prognosis (poor responder patients). Taken together, these data show that MT2A contributes to chemotherapy resistance in osteosarcoma, an effect partially mediated by zinc chelation. The data also suggest that MT2A may be a potential new prognostic marker for osteosarcoma sensitivity to chemotherapy.

  2. Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells.

    Science.gov (United States)

    Kuete, Victor; Tankeo, Simplice B; Saeed, Mohamed E M; Wiench, Benjamin; Tane, Pierre; Efferth, Thomas

    2014-04-11

    Beilschmiedia acuta Kosterm, Clausena anisata (Willd) Hook, Fagara tessmannii Engl., Newbouldia laevis Seem., and Polyscias fulva (Hiern) Harms. are medicinal plants used in Cameroonian traditional medicine in the treatment of various types of cancers. The present study aims at investigating 11 methanolic extracts from the above Cameroonian medicinal plants on a panel of human cancer cell lines, including various drug-resistant phenotypes. Possible modes of action were analyzed for two extracts from Beilschmiedia acuta and Polyscia fulva and alpha-hederin, the representative constituent of Polyscia fulva. Cytotoxicity was determined using a resazurin assay. Cell cycle, apoptosis, mitochondrial membrane potential (MMP), and reactive oxygen species (ROS) were measured by flow cytometry. Cellular response to alpha-hederin was investigated by a mRNA microarray approach. Prescreening of extracts (40µg/mL) showed that three of eleven plant extracts inhibited proliferation of CCRF-CEM cells by more than 50%, i.e. BAL (73.65%), the bark extract of Beilschmiedia acuta (78.67%) and PFR (68.72%). Subsequent investigations revealed IC50 values below or around 30µg/mL of BAL and PFR in 10 cell lines, including drug-resistant models, i.e. P-glycoprotein-overexpressing CEM/ADR5000, breast cancer resistance protein-transfected MDA-MB-231-BCRP, TP53 knockout cells (HCT116 p53(-/-)), and mutation-activated epidermal growth factor receptor-transfected U87MG.ΔEGFR cells. IC50 values below 5µg/mL of BAL were obtained for HCT116 (p53(-/-)) cells. IC50 values below 10µM of alpha-hederin were found for sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 cells. The BAL and PFR extracts induced cell cycle arrest between G0/G1 and S phases. PFR-induced apoptosis was associated with increased ROS generation and MMP breakdown. Microarray-based cluster analysis revealed a gene expression profile that predicted cellular response to alpha-hederin. BAL, PFL and alpha-hederin, an

  3. Addressing Antimicrobial Resistance: An Overview of Priority Actions to Prevent Suboptimal Antimicrobial Use in Food-Animal Production.

    Science.gov (United States)

    Lhermie, Guillaume; Gröhn, Yrjö T; Raboisson, Didier

    2016-01-01

    The growing concern regarding emergence of bacteria resistant to antimicrobials and their potential for transmission to humans via animal production has led various authorities worldwide to implement measures to decrease antimicrobial use (AMU) in livestock production. These measures are influenced by those implemented in human medicine, and emphasize the importance of antimicrobial stewardship, surveillance, infection prevention and control and research. In food producing animals, unlike human medicine, antimicrobials are used to control diseases which cause economic losses. This major difference may explain the failure of the public policies implemented to control antimicrobial usage. Here we first review the specific factors influencing AMU across the farm animal sector and highlighting the farmers' decision-making process of AMU. We then discuss the efficiency of existing regulations implemented by policy makers, and assess the need for alternative strategies, such as substitution between antimicrobials and other measures for infectious disease control. We also discuss the interests of regulating antimicrobial prices. Finally, we emphasize the value of optimizing antimicrobial regimens, and developing veterinary precision medicine to achieve clinical efficacy in animals while limiting negative impacts on public health. The fight against antimicrobial resistance requires both a reduction and an optimization of antimicrobial consumption. The set of actions currently implemented by policy makers does not adequately address the economic interests of farmers' use of antimicrobials.

  4. A novel action of deltamethrin on membrane resistance in mammalian skeletal muscle and non-myelinated nerve fibres.

    Science.gov (United States)

    Forshaw, P J; Ray, D E

    1990-01-01

    The pyrethroids, deltamethrin and cismethrin, were assessed for their ability to change membrane conductance directly in skeletal muscle and indirectly in non-myelinated nerve fibre preparations from the rat. In diaphragm muscle fibres of the rat, input resistance was significantly increased (35%) by deltamethrin but not by cismethrin, compared with solvent alone. In perfused vagus nerve from the rat, the amplitude of the post-tetanic hyperpolarization was significantly increased (100%) by deltamethrin both in vitro and ex vivo but not by cismethrin or solvent. In both test systems the actions of deltamethrin were abolished by changing the perfusate to a low chloride solution. The enhancement of amplitude of post-tetanic hyperpolarization by deltamethrin was reversed by ivermectin, a compound known to increase the resting chloride flux in neuronal preparations. Depolarizing afterpotentials, indicative of a prolongation in sodium conductance, did not develop until 0.5-1.0 hr after the enhancement of the amplitude of post-tetanic hyperpolarization by deltamethrin in the vagus preparations. The amplitude of post-tetanic hyperpolarization was not enhanced by exposure of the vagus to veratrine. These observations reinforce the conclusion that the enhancement of post-tetanic hyperpolarization by deltamethrin is not the result of intracellular accumulation of sodium. In addition, the chloride-dependent nature of the effects of deltamethrin, in both muscle and non-myelinated nerve, suggests that they are in both cases due to a reduction in resting membrane chloride conductance. This novel action of deltamethrin would be expected to amplify the effect of prolonged sodium current and thus influence the actions on excitable membranes both directly and indirectly.

  5. A thiazolidinedione improves in vivo insulin action on skeletal muscle glycogen synthase in insulin-resistant monkeys.

    Science.gov (United States)

    Ortmeyer, H K; Bodkin, N L; Haney, J; Yoshioka, S; Horikoshi, H; Hansen, B C

    2000-01-01

    Thiazolidinediones (TZD) have been shown to have anti-diabetic effects including the ability to decrease fasting hyperglycemia and hyperinsulinemia, increase insulin-mediated glucose disposal rate (M) and decrease hepatic glucose production, but the mechanisms of action are not well established. To determine whether a TZD (R-102380, Sankyo Company Ltd., Tokyo, Japan) could improve insulin action on skeletal muscle glycogen synthase (GS), the rate-limiting enzyme in glycogen synthesis, 4 insulin-resistant obese monkeys were given 1 mg/kg/day R-102380 p.o. for a 6-week period. Skeletal muscle GS activity and glucose 6-phosphate (G6P) content were compared between pre-dosing and dosing periods before and during the maximal insulin-stimulation of a euglycemic hyperinsulinemic clamp. Compared to pre-dosing, insulin-stimulated GS activity and G6P content were increased by this TZD: GS independent activity (p = 0.02), GS total activity (p = 0.005), GS fractional activity (p = 0.06) and G6P content (p = 0.02). The change in GS activity induced by in vivo insulin (insulin-stimulated minus basal) was also increased by this TZD: GS independent activity (p = 0.03) and GS fractional activity (p = 0.04). We conclude that the TZD R-102380 improves insulin action at the skeletal muscle in part by increasing the activity of glycogen synthase. This improvement in insulin sensitivity may be a key factor in the anti-diabetic effect of the thiazolidinedione class of agents.

  6. Benefits of Nut Consumption on Insulin Resistance and Cardiovascular Risk Factors: Multiple Potential Mechanisms of Actions

    Directory of Open Access Journals (Sweden)

    Yoona Kim

    2017-11-01

    Full Text Available Epidemiological and clinical studies have indicated that nut consumption could be a healthy dietary strategy to prevent and treat type 2 diabetes (T2DM and related cardiovascular disease (CVD. The objective of this review is to examine the potential mechanisms of action of nuts addressing effects on glycemic control, weight management, energy balance, appetite, gut microbiota modification, lipid metabolism, oxidative stress, inflammation, endothelial function and blood pressure with a focus on data from both animal and human studies. The favourable effects of nuts could be explained by the unique nutrient composition and bioactive compounds in nuts. Unsaturated fatty acids (monounsaturated fatty acids and polyunsaturated fatty acids present in nuts may play a role in glucose control and appetite suppression. Fiber and polyphenols in nuts may also have an anti-diabetic effect by altering gut microbiota. Nuts lower serum cholesterol by reduced cholesterol absorption, inhibition of HMG-CoA reductase and increased bile acid production by stimulation of 7-α hydroxylase. Arginine and magnesium improve inflammation, oxidative stress, endothelial function and blood pressure. In conclusion, nuts contain compounds that favourably influence glucose homeostasis, weight control and vascular health. Further investigations are required to identify the most important mechanisms by which nuts decrease the risk of T2DM and CVD.

  7. Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone

    Science.gov (United States)

    Halloran, B. P.; Bikle, D. D.; Harris, J.; Autry, C. P.; Currier, P. A.; Tanner, S.; Patterson-Buckendahl, P.; Morey-Holton, E.

    1995-01-01

    Loss of skeletal weight bearing or physical unloading of bone in the growing animal inhibits bone formation and induces a bone mineral deficit. To determine whether the inhibition of bone formation induced by skeletal unloading in the growing animal is a consequence of diminished sensitivity to growth hormone (GH) we studied the effects of skeletal unloading in young hypophysectomized rats treated with GH (0, 50, 500 micrograms/100 g body weight/day). Skeletal unloading reduced serum osteocalcin, impaired uptake of 3H-proline into bone, decreased proximal tibial mass, and diminished periosteal bone formation at the tibiofibular junction. When compared with animals receiving excipient alone, GH administration increased bone mass in all animals. The responses in serum osteocalcin, uptake of 3H-proline and 45Ca into the proximal tibia, and proximal tibial mass in non-weight bearing animals were equal to those in weight bearing animals. The responses in trabecular bone volume in the proximal tibia and bone formation at the tibiofibular junction to GH, however, were reduced significantly by skeletal unloading. Bone unloading prevented completely the increase in metaphyseal trabecular bone normally induced by GH and severely dampened the stimulatory effect (158% vs. 313%, p bone formation. These results suggest that while GH can stimulate the overall accumulation of bone mineral in both weight bearing and non-weight bearing animals, skeletal unloading selectively impairs the response of trabecular bone and periosteal bone formation to the anabolic actions of GH.

  8. 77 FR 31302 - Advisory Committee on Agriculture Statistics

    Science.gov (United States)

    2012-05-25

    ... DEPARTMENT OF AGRICULTURE National Agricultural Statistics Service Advisory Committee on Agriculture Statistics AGENCY: National Agricultural Statistics Service, USDA. ACTION: Notice of Renewal of the Charter for the Advisory Committee on Agriculture Statistics. SUMMARY: The U.S. Department of...

  9. 76 FR 40753 - NASA Advisory Council; Aeronautics Committee; Meeting

    Science.gov (United States)

    2011-07-11

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (11-059)] NASA Advisory Council; Aeronautics Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of..., the National Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of...

  10. 78 FR 37781 - Forest Resource Coordinating Committee; Meeting

    Science.gov (United States)

    2013-06-24

    ... DEPARTMENT OF AGRICULTURE Forest Service Forest Resource Coordinating Committee; Meeting AGENCY: Forest Service, USDA. ACTION: Notice of meeting; Correction. SUMMARY: The Forest Service published a... teleconference line. FOR FURTHER INFORMATION CONTACT: Maya Solomon, Forest Resource Coordinating Committee...

  11. 77 FR 35102 - Commercial Space Transportation Advisory Committee; Public Teleconference

    Science.gov (United States)

    2012-06-12

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee; Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  12. 78 FR 53496 - Commercial Space Transportation Advisory Committee; Public Teleconference

    Science.gov (United States)

    2013-08-29

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee; Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  13. 78 FR 14401 - Commercial Space Transportation Advisory Committee; Public Teleconference

    Science.gov (United States)

    2013-03-05

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee; Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  14. 76 FR 78329 - Commercial Space Transportation Advisory Committee; Public Teleconference

    Science.gov (United States)

    2011-12-16

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee; Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  15. 75 FR 72792 - Commerce Spectrum Management Advisory Committee Meeting

    Science.gov (United States)

    2010-11-26

    ... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration Commerce... Administration, U.S. Department of Commerce. ACTION: Notice of open meeting by teleconference. SUMMARY: This notice announces a public meeting of the Commerce Spectrum Management Advisory Committee (Committee...

  16. 76 FR 3605 - Collaborative Forest Landscape Restoration Program Advisory Committee

    Science.gov (United States)

    2011-01-20

    ... Forest Service Collaborative Forest Landscape Restoration Program Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Collaborative Forest Landscape Restoration Program... Forest Landscape Restoration Program matters to the attention of the Committee may file written...

  17. 78 FR 39301 - Committee name: Homeland Security Academic Advisory Council

    Science.gov (United States)

    2013-07-01

    ... leadership on matters relating to student and recent graduate recruitment; international students; academic... Academic Advisory Council AGENCY: Department of Homeland Security. ACTION: Committee Management; Notice of Federal Advisory Committee Meeting. SUMMARY: The Homeland Security Academic Advisory Council (HSAAC) will...

  18. 76 FR 82031 - Commercial Space Transportation Advisory Committee; Public Teleconference

    Science.gov (United States)

    2011-12-29

    ... Advisory Committee; Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... Committee (COMSTAC) Risk Management Working Group. The teleconference will take place on Tuesday, January 24... providers for missions transporting NASA astronauts to and from the International Space Station. NASA's...

  19. 76 FR 21936 - Aviation Rulemaking Advisory Committee-New Task

    Science.gov (United States)

    2011-04-19

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Aviation Rulemaking Advisory Committee--New Task AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of new task assignment for the Aviation Rulemaking Advisory Committee (ARAC). SUMMARY: The FAA assigned the Aviation...

  20. 76 FR 81009 - Aviation Rulemaking Advisory Committee-New Task

    Science.gov (United States)

    2011-12-27

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Aviation Rulemaking Advisory Committee--New Task AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of new task assignment for the Aviation Rulemaking Advisory Committee (ARAC). SUMMARY: The FAA assigned the Aviation...

  1. 77 FR 10797 - Aviation Rulemaking Advisory Committee-New Task

    Science.gov (United States)

    2012-02-23

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Aviation Rulemaking Advisory Committee--New Task AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of withdrawal of task assignment for the Aviation Rulemaking Advisory Committee (ARAC). SUMMARY: The FAA has withdrawn a task...

  2. 77 FR 56909 - Aviation Rulemaking Advisory Committee (ARAC); Renewal

    Science.gov (United States)

    2012-09-14

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Aviation Rulemaking Advisory Committee (ARAC); Renewal AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Renewal. SUMMARY: The FAA announces the charter renewal of the Aviation Rulemaking Advisory Committee (ARAC), a...

  3. 75 FR 60493 - Aviation Rulemaking Advisory Committee; Renewal

    Science.gov (United States)

    2010-09-30

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Aviation Rulemaking Advisory Committee; Renewal AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Renewal. SUMMARY... Aviation Rulemaking Advisory Committee (ARAC) for a 2-year period beginning September 17, 2010. The...

  4. 76 FR 2662 - Visiting Committee on Advanced Technology

    Science.gov (United States)

    2011-01-14

    ... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Visiting Committee on Advanced Technology AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of partially closed meeting. SUMMARY: The Visiting Committee on Advanced Technology (VCAT...

  5. 75 FR 28785 - Visiting Committee on Advanced Technology

    Science.gov (United States)

    2010-05-24

    ... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Visiting Committee on Advanced Technology AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of Partially Closed Meeting. SUMMARY: The Visiting Committee on Advanced Technology (VCAT...

  6. 78 FR 25252 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2013-04-30

    ...-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee will meet on May 6, 2013, (alternate...

  7. 78 FR 29145 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2013-05-17

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2013-0022] President's National Security Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... notice of a May 22, 2013, meeting of the President's National Security Telecommunications Advisory...

  8. 76 FR 32390 - Motor Carrier Safety Advisory Committee Public Meeting

    Science.gov (United States)

    2011-06-06

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006-26367] Motor Carrier Safety Advisory Committee Public Meeting AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of Motor Carrier Safety Advisory Committee (MCSAC) Meeting. SUMMARY...

  9. 77 FR 46555 - Motor Carrier Safety Advisory Committee: Public Meeting

    Science.gov (United States)

    2012-08-03

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006-26367] Motor Carrier Safety Advisory Committee: Public Meeting AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of meeting of Motor Carrier Safety Advisory Committee (MCSAC...

  10. 75 FR 2923 - Motor Carrier Safety Advisory Committee Public Meeting

    Science.gov (United States)

    2010-01-19

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006-26367] Motor Carrier Safety Advisory Committee Public Meeting AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of Motor Carrier Safety Advisory Committee Meeting. SUMMARY: FMCSA...

  11. 75 FR 29384 - Motor Carrier Safety Advisory Committee Public Meeting

    Science.gov (United States)

    2010-05-25

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2010-0143] Motor Carrier Safety Advisory Committee Public Meeting AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of Motor Carrier Safety Advisory Committee meeting. SUMMARY: FMCSA...

  12. 75 FR 72863 - Motor Carrier Safety Advisory Committee Public Meeting

    Science.gov (United States)

    2010-11-26

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006-26367] Motor Carrier Safety Advisory Committee Public Meeting AGENCY: Federal Motor Carrier Safety Administration, DOT. ACTION: Notice of Motor Carrier Safety Advisory Committee Meeting. SUMMARY: FMCSA announces...

  13. 75 FR 50797 - Motor Carrier Safety Advisory Committee Public Meeting

    Science.gov (United States)

    2010-08-17

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2010-0143] Motor Carrier Safety Advisory Committee Public Meeting AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of Motor Carrier Safety Advisory Committee Meeting. SUMMARY: FMCSA...

  14. Synergistic action of fatty acids, sulphides and stilbene against acaricide-resistant Rhipicephalus microplus ticks.

    Science.gov (United States)

    Arceo-Medina, G N; Rosado-Aguilar, J A; Rodríguez-Vivas, R I; Borges-Argaez, R

    2016-09-15

    Six compounds in a methanolic extract of Petiveria alliacea stem (cis-stilbene; benzyl disulphide; benzyl trisulphide; and methyl esters of hexadecanoic acid, octadecadienoic acid and octadecenoic acid) are known to exercise acaricide activity against cattle tick Rhipicephalus microplus larvae and adults. The synergistic effect of 57 combinations of these six compounds on acaricide activity against R. microplus was evaluated. Larvae immersion tests produced the lethal concentrations needed to kill 50% (LC 50 ) and 99% (LC 99 ) of the population. Adult immersion tests produced rates (%) for mortality, oviposition inhibition and eclosion inhibition. Individually, none of the compounds (1% concentration) exhibited acaricide activity (mortality ≤2.3%). When combined, however, nine mixtures exhibited a synergistic increase in activity, with high mortality rates (≥92%) in larvae. Values for LC 50 ranged from 0.07 to 0.51% and those for LC 99 from 0.66 to 5.16%. Thirty six compound mixtures had no significant activity (mortality ≤30%) against larvae. Two mixtures exhibited synergism against adults, with high rates (≥92%) of oviposition inhibition. The mixtures based on the benzyl disulphide+benzyl trisulphide pairing produced a synergistic effect against acaricide-resistant R. microplus larva and adults, and are therefore the most promising combination for controlling this ubiquitous ectoparasite. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Conservation Action Handbook.

    Science.gov (United States)

    National Rifle Association, Washington, DC.

    Conservation problems are identified, with some suggestions for action. General areas covered are: Wildlife Conservation, Soil Conservation, Clean Water, Air Pollution Action, and Outdoor Recreation Action. Appendices list private organizations or agencies concerned with natural resource use and/or management, congressional committees considering…

  16. Impaired anti-inflammatory action of glucocorticoid in neutrophil from patients with steroid-resistant asthma.

    Science.gov (United States)

    Wang, Meijia; Gao, Pengfei; Wu, Xiaojie; Chen, Yuetao; Feng, Yikuan; Yang, Qun; Xu, Yongjian; Zhao, Jianping; Xie, Jungang

    2016-11-16

    Steroid resistant (SR) asthma is characterized by persistent airway inflammation that fails to resolve despite treatment with high doses of corticosteroids. Furthermore, SR patient airways show increased numbers neutrophils, which are less responsive to glucocorticoid. The present study seeks to determine whether dexamethasone (DEX) has different effect on neutrophils from steroid sensitive (SS) asthmatics compared to SR asthmatics. Adults with asthma (n = 38) were classified as SR or SS based on changes in lung FEV1% following a one-month inhaled corticosteroid (ICS) treatment. Blood samples were collected from all patients during their first visit of the study. Neutrophils isolated from the blood were cultured with dexamethasone and/or atopic asthmatic serum for 18 h. The mRNA expression of mitogen-activated protein kinase phosphatase-1 (MKP-1), a glucocorticoid transactivation target, and glucocorticoid-induced transcript 1 (GLCCI1), an early marker of glucocorticoid-induced apoptosis whose expression was associated with the response to inhaled glucocorticoids in asthma , was determined by real-time PCR, and ELISA was used to assess the pro-inflammatory cytokine IL-8 levels in the supernatant. Constitutive neutrophil apoptosis was detected by flow cytometry. DEX significantly induced MKP-1 expression in both patients with SS and SR patients in a concentration-dependent manner, but greater induction was observed for SS patients at a low concentration (10 -6 M). Asthmatic serum alone showed no MKP-1expression, and there was impaired induction of MKP-1 by DEX in SR asthma patients. The expression of GLCCI1 was not induced in neutrophils with DEX or DEX/atopic asthmatic serum combination. Greater inhibition of IL-8 production was observed in neutrophils from patients with SS asthma treated with DEX/atopic asthmatic serum combination compared with SR asthma patients, though DEX alone showed the same effect on neutrophils from SS and SR asthma patients. Meanwhile

  17. Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.

    Directory of Open Access Journals (Sweden)

    Siew Pheng Lim

    2016-08-01

    Full Text Available Flaviviruses comprise major emerging pathogens such as dengue virus (DENV or Zika virus (ZIKV. The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp domain of non-structural protein 5 (NS5. This essential enzymatic activity renders the RdRp attractive for antiviral therapy. NS5 synthesizes viral RNA via a "de novo" initiation mechanism. Crystal structures of the flavivirus RdRp revealed a "closed" conformation reminiscent of a pre-initiation state, with a well ordered priming loop that extrudes from the thumb subdomain into the dsRNA exit tunnel, close to the "GDD" active site. To-date, no allosteric pockets have been identified for the RdRp, and compound screening campaigns did not yield suitable drug candidates. Using fragment-based screening via X-ray crystallography, we found a fragment that bound to a pocket of the apo-DENV RdRp close to its active site (termed "N pocket". Structure-guided improvements yielded DENV pan-serotype inhibitors of the RdRp de novo initiation activity with nano-molar potency that also impeded elongation activity at micro-molar concentrations. Inhibitors exhibited mixed inhibition kinetics with respect to competition with the RNA or GTP substrate. The best compounds have EC50 values of 1-2 μM against all four DENV serotypes in cell culture assays. Genome-sequencing of compound-resistant DENV replicons, identified amino acid changes that mapped to the N pocket. Since inhibitors bind at the thumb/palm interface of the RdRp, this class of compounds is proposed to hinder RdRp conformational changes during its transition from initiation to elongation. This is the first report of a class of pan-serotype and cell-active DENV RdRp inhibitors. Given the evolutionary conservation of residues lining the N pocket, these molecules offer insights to treat other serious conditions caused by flaviviruses.

  18. Year 2000 Computing Challenge: Education Taking Needed Actions but Work Remains. Testimony before the Subcommittee on Oversight and Investigations, Committee on Education and the Workforce, House of Representatives.

    Science.gov (United States)

    Willemssen, Joel C.

    This document provides testimony on the U.S. Department of Education's efforts to ensure that its computer systems supporting critical student financial aid activities will be able to process information reliably through the turn of the century. After providing some background information, the statement recaps prior findings and the actions that…

  19. Feeding on poplar leaves by caterpillars potentiates foliar peroxidase action in their guts and increases plant resistance.

    Science.gov (United States)

    Barbehenn, Raymond; Dukatz, Chris; Holt, Chris; Reese, Austin; Martiskainen, Olli; Salminen, Juha-Pekka; Yip, Lynn; Tran, Lan; Constabel, C Peter

    2010-12-01

    Peroxidases (PODs) are believed to act as induced and constitutive defenses in plants against leaf-feeding insects. However, little work has examined the mode of action of PODs against insects. Putative mechanisms include the production of potentially antinutritive and/or toxic semiquinone free radicals and quinones (from the oxidation of phenolics), as well as increased leaf toughness. In this study, transgenic hybrid poplar saplings (Populus tremula × Populus alba) overexpressing horseradish peroxidase (HRP) were produced to examine the impact of elevated HRP levels on the performance and gut biochemistry of Lymantria dispar caterpillars. HRP-overexpressing poplars were more resistant to L. dispar than wild-type (WT) poplars when the level of a phenolic substrate of HRP (chlorogenic acid) was increased, but only when leaves had prior feeding damage. Damaged (induced) leaves produced increased amounts of hydrogen peroxide, which was used by HRP to increase the production of semiquinone radicals in the midguts of larvae. The decreased growth rates of larvae that fed on induced HRP-overexpressing poplars resulted from post-ingestive mechanisms, consistent with the action of HRP in their midguts. The toughness of HRP-overexpressing leaves was not significantly greater than that of WT leaves, whether or not they were induced. When leaves were coated with ellagitannins, induced HRP leaves also produced elevated levels of semiquinone radicals in the midgut. Decreased larval performance on induced HRP leaves in this case was due to post-ingestive mechanisms as well as decreased consumption. The results of this study provide the first demonstration that a POD is able to oxidize phenolics within an insect herbivore's gut, and further clarifies the chemical conditions that must be present for PODs to function as antiherbivore defenses.

  20. Synergistic activity of luteolin and amoxicillin combination against amoxicillin-resistant Escherichia coli and mode of action.

    Science.gov (United States)

    Eumkeb, G; Siriwong, S; Thumanu, K

    2012-12-05

    The purpose of this research was to investigate whether luteolin has antibacterial and synergistic activity against amoxicillin-resistant Escherichia coli (AREC) when use singly and in combination with amoxicillin. The primarily mode of action is also investigated. The susceptibility assay (minimum inhibitory concentration and checkerboard determination) was carried out by the broth macrodilution method's in Müeller-Hinton medium. MIC and checkerboard determination were carried out after 20 h of incubation at 35°C by observing turbidity. The MICs of amoxicillin and luteolin against all AREC strains were >1000 and ≥ 200 μg/ml respectively. Synergistic activity were observed on amoxicillin plus luteolin against these strains. Viable count of this combination showed synergistic effect by reducing AREC cell numbers. The results indicated that this combination altered both outer and inner membrane permeabilisation. Enzyme assay showed that luteolin had an inhibitory activity against penicillinase. Fourier Transform-Infrared (FT-IR) spectroscopy exhibited that luteolin alone and when combined with amoxicillin caused increase in fatty acid and nucleic acid, but decrease in amide I of proteins in bacterial envelops compared with control. These results indicated that luteolin has the potential to reverse bacterial resistance to amoxicillin in AREC and may operate via three mechanisms: inhibition of proteins and peptidoglycan synthesis, inhibition of the activity of certain extended-spectrum β-lactamases and alteration of outer and inner membrane permeability. These findings offer the potential to develop a new generation of phytopharmaceuticals to treat AREC. Copyright © 2012 Elsevier B.V. All rights reserved.

  1. The use of an electric field in increasing the resistance of plants to the action of unfavorable space flight factors

    Science.gov (United States)

    Nechitailo, G.; Gordeev, A.

    2004-01-01

    The key role in increasing the resistance of plants to unfavorable space flight factors is assigned to biomembranes of root cells. It is these biomembranes in which numerous biochemical and biophysical processes determining the adaptive capacity of plant organisms occur. In the initial period of exposure to unfavorable space flight factors the adaptation reactions of the plant organism undoubtedly increase its resistance. But the intensification of removal of H + ions through the plasmalemma with an increase of the external influence sharply raises the quantity of cations leaving the cell, which leads to the accumulation of a considerable quantity of intracellular negative charges. These charges together with negative charges built in the membrane force protons to concentrate on the external surface of the membrane. Since protons have a very strong electric field, they form such a charge of which the electric field is about from several to hundreds of V/cm. The concentration of positive charges of protons entails the formation of a double electric field which extremely impedes the diffusion of other ions. Thus, a proton barrier is formed. Its length can be very considerable due to which the whole process of transmembrane energy and mass-transfer is disturbed. The proton barrier is easily destroyed by a weak electric field created in the root zone. In experiments on electrostimulation of different plants under space flight conditions at the orbital station MIR the absorption of nutrient elements by the root system increased to the optimal level, the ratio of physiologically active substances in the rhizosphere was normalized, the content of chlorophyll, carotin, and ascorbic acid in leaves corresponded to the ground-based control. Understanding of the mechanism of formation of a proton barrier on the plasmalemma of root cells as a result of the response of plants to the negative action of external factors (microgravity) is of great importance. It allows the

  2. The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus.

    Science.gov (United States)

    Leung, Po Sing

    2016-03-05

    Vitamin D deficiency (i.e., hypovitaminosis D) is associated with increased insulin resistance, impaired insulin secretion, and poorly controlled glucose homeostasis, and thus is correlated with the risk of metabolic diseases, including type 2 diabetes mellitus (T2DM). The liver plays key roles in glucose and lipid metabolism, and its dysregulation leads to abnormalities in hepatic glucose output and triglyceride accumulation. Meanwhile, the pancreatic islets are constituted in large part by insulin-secreting β cells. Consequently, islet dysfunction, such as occurs in T2DM, produces hyperglycemia. In this review, we provide a critical appraisal of the modulatory actions of vitamin D in hepatic insulin sensitivity and islet insulin secretion, and we discuss the potential roles of a local vitamin D signaling in regulating hepatic and pancreatic islet functions. This information provides a scientific basis for establishing the benefits of the maintenance, or dietary manipulation, of adequate vitamin D status in the prevention and management of obesity-induced T2DM and non-alcoholic fatty liver disease.

  3. 75 FR 69698 - Invasive Species Advisory Committee

    Science.gov (United States)

    2010-11-15

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of public meetings of the Invasive Species Advisory... of meetings of the Invasive Species Advisory Committee (ISAC). Comprised of 30 nonfederal invasive...

  4. 76 FR 68776 - Invasive Species Advisory Committee

    Science.gov (United States)

    2011-11-07

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of public meetings of the Invasive Species Advisory... of meetings of the Invasive Species Advisory Committee (ISAC). Comprised of 29 nonfederal invasive...

  5. 77 FR 23740 - Invasive Species Advisory Committee

    Science.gov (United States)

    2012-04-20

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of Public Meetings of the Invasive Species Advisory... of meetings of the Invasive Species Advisory Committee (ISAC). Comprised of 30 nonfederal invasive...

  6. 78 FR 6806 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-01-31

    ... DEPARTMENT OF AGRICULTURE Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Forest Resource Committee Meeting will meet in... address the national priorities for non- industrial private forest land. The purpose of the meeting is...

  7. 76 FR 70412 - Smart Grid Advisory Committee

    Science.gov (United States)

    2011-11-14

    ... National Institute of Standards and Technology Smart Grid Advisory Committee AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Smart Grid... agenda may change to accommodate Committee business. The final agenda will be posted on the Smart Grid...

  8. 75 FR 55306 - Smart Grid Advisory Committee

    Science.gov (United States)

    2010-09-10

    ... National Institute of Standards and Technology Smart Grid Advisory Committee AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Smart Grid... provide an update on NIST's Smart Grid program. The agenda may change to accommodate Committee business...

  9. 76 FR 78252 - Nuclear Energy Advisory Committee

    Science.gov (United States)

    2011-12-16

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of Renewal. SUMMARY: Pursuant to Section 14(a)(2)(A) of the Federal... hereby given that the Nuclear Energy Advisory Committee will be renewed for a two-year period. The...

  10. 78 FR 70932 - Nuclear Energy Advisory Committee

    Science.gov (United States)

    2013-11-27

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear[email protected]nuclear.energy.gov . SUPPLEMENTARY INFORMATION: Background: The Nuclear Energy Advisory Committee (NEAC...

  11. 78 FR 73819 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-12-09

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of Cancellation. SUMMARY: The U.S. Department of Agriculture, Forest Service was required to cancel the October 17-18, 2013 meeting of the Forest Resource Coordinating Committee due to the Government partial shutdown...

  12. 75 FR 61454 - Electricity Advisory Committee

    Science.gov (United States)

    2010-10-05

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Department of Energy, Office of Electricity Delivery and Energy Reliability. ACTION: Notice of open meeting. SUMMARY: This notice announces the open meeting of the re-established DOE Electricity Advisory Committee. The Federal Advisory...

  13. 78 FR 61348 - Electricity Advisory Committee

    Science.gov (United States)

    2013-10-03

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Department of Energy. ACTION: Notice of Cancellation of Open Meeting. SUMMARY: On September 11, 2013, in FR Doc. 2013-22119, on pages... October 2-3, 2013 of the Electricity Advisory Committee (78 FR 55692). This notice announces the...

  14. 76 FR 59667 - Methane Hydrate Advisory Committee

    Science.gov (United States)

    2011-09-27

    ... DEPARTMENT OF ENERGY Methane Hydrate Advisory Committee AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Methane...-5600. SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Methane Hydrate Advisory...

  15. 77 FR 40032 - Methane Hydrate Advisory Committee

    Science.gov (United States)

    2012-07-06

    ... DEPARTMENT OF ENERGY Methane Hydrate Advisory Committee AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Methane... of the Methane Hydrate Advisory Committee is to provide advice on potential applications of methane...

  16. 78 FR 50040 - Technology Advisory Committee

    Science.gov (United States)

    2013-08-16

    ... Trading Commission. ACTION: Notice of Meeting of Technology Advisory Committee. SUMMARY: The Commodity... of the Secretary. Please use the title ``Technology Advisory Committee'' in any written statement you... standardization in the context of SDR data reporting; (2) the Commission's upcoming concept release on automated...

  17. Vision Hampton Roads : strategy committee minutes & attendance.

    Science.gov (United States)

    2010-02-22

    February 20, 2009 : HRP Executive Committee Meeting, Looking Back, Looking Forward : March 20, 2009 : HRP Board Meeting, Accolades & Action, Doing Things Jointly with Comprehensive : Economic Development Strategies : April 17,...

  18. 75 FR 27557 - Federal Advisory Committee Act

    Science.gov (United States)

    2010-05-17

    ... to announce that the Federal Communications Commission (FCC) has renewed the charter for the Advisory... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY...

  19. Study of resistance of D. radiodurans to the combined action of ionizing radiation with an electric or magnetic fields exogenous

    International Nuclear Information System (INIS)

    Prado, Georgia Reis

    2011-01-01

    The key goal in radiotherapy is to maximize damages in a tumor while minimizing them in nearby health tissues. Several strategies have been worked out toward the enhancement of cellular radiosensitivity, as the use of exogenous fields. It is studied in this work the resistance of Deinococcus radiodurans to the combined action of conventional and non conventional radiations, with external agents (electric and magnetic fields). D. radiodurans is a bacterium having an extraordinary ability to cope with lethal and mutagenic agents harmful to the DNA, particularly ionizing radiations as gammas and UV. Given its high radioresistance and fast growing, D. radiodurans has been used as solid tumors simulators. Peculiarities associated with radioresistance at the exponential and stationary phases were delineated from growing curves. By measuring survival curves information on radiosensitivity was obtained. In gamma irradiation D. radiodurans exhibited repairing shoulders of 2 and 8 kGy at the exponential and stationary phases, respectively. When gamma irradiations were combined with expositions to the electric field the repairing shoulders were reduced to 1 and 4 kGy at the exponential and stationary phases, respectively. Radioresistance was similar in both growing phases when the number of cells were approximately equalized in these two processes. On the other hand, when gamma irradiations were combined with expositions to the magnetic field the repairing shoulders were reduced to 4 and 6 kGy at the exponential and stationary phases, respectively. In irradiations with electron beams the repairing shoulder at the exponential phase was totally depleted, while at the stationary phase it was only 1 kGy. The findings of this work revealed new and important information on the radioresistance of D. radiodurans, while providing hints to the improvement of radiotherapy protocols in association with exogenous physical agents. (author)

  20. 75 FR 41838 - Basic Energy Sciences Advisory Committee

    Science.gov (United States)

    2010-07-19

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat...

  1. 76 FR 48147 - Basic Energy Sciences Advisory Committee

    Science.gov (United States)

    2011-08-08

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of renewal of the Basic Energy Sciences Advisory Committee. SUMMARY... that the Basic Energy Sciences Advisory Committee will be renewed for a two-year period beginning July...

  2. 75 FR 6369 - Basic Energy Sciences Advisory Committee

    Science.gov (United States)

    2010-02-09

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  3. 78 FR 15937 - Fusion Energy Sciences Advisory Committee

    Science.gov (United States)

    2013-03-13

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Fusion Energy Sciences Advisory Committee. The Federal Advisory Committee Act requires that public notice of...

  4. 75 FR 8685 - Fusion Energy Sciences Advisory Committee

    Science.gov (United States)

    2010-02-25

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Fusion Energy Sciences Advisory Committee. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  5. 76 FR 41234 - Basic Energy Sciences Advisory Committee

    Science.gov (United States)

    2011-07-13

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  6. 78 FR 38696 - Basic Energy Sciences Advisory Committee

    Science.gov (United States)

    2013-06-27

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat...

  7. 77 FR 41395 - Basic Energy Sciences Advisory Committee

    Science.gov (United States)

    2012-07-13

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  8. 76 FR 8358 - Basic Energy Sciences Advisory Committee

    Science.gov (United States)

    2011-02-14

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  9. 76 FR 40714 - Fusion Energy Sciences Advisory Committee

    Science.gov (United States)

    2011-07-11

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Fusion Energy Sciences Advisory Committee. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  10. 77 FR 53902 - Aviation Security Advisory Committee (ASAC) Meeting

    Science.gov (United States)

    2012-09-04

    ...] Aviation Security Advisory Committee (ASAC) Meeting AGENCY: Transportation Security Administration, DHS... Security Administration (TSA) will hold a meeting of the Aviation Security Advisory Committee (ASAC) on... Air Cargo Security Sub-committee and the Report on the Actions of the International Aviation Sub...

  11. 78 FR 41795 - Farm, Ranch, and Rural Communities Committee Teleconference

    Science.gov (United States)

    2013-07-11

    ... Communities Committee Teleconference AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Public..., EPA gives notice of a teleconference meeting of the Farm, Ranch, and Rural Communities Committee (FRRCC). The FRRCC is a policy-oriented committee that provides policy advice, information, and...

  12. 77 FR 65393 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2012-10-26

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Security Telecommunications Advisory Committee (NSTAC) will meet on Monday, November 5, 2012, via a... preparedness (NS/EP) telecommunications policy. Agenda: The NSTAC members will receive an update on progress...

  13. 76 FR 17424 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2011-03-29

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Telecommunications Advisory Committee (NSTAC) will meet on Tuesday, April 19, 2011, via a conference call. The... matters related to national security and emergency preparedness telecommunications policy. The NSTAC Chair...

  14. 78 FR 63232 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2013-10-23

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Telecommunications Advisory Committee (NSTAC) will meet on Wednesday, November 20, 2013. The meeting will be open to... preparedness (NS/EP) telecommunications policy. During the meeting, the Industrial Internet Subcommittee Co...

  15. 77 FR 44641 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2012-07-30

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Security Telecommunications Advisory Committee (NSTAC) will meet on Thursday, August 16, 2012, via a... preparedness telecommunications policy. Agenda: The NSTAC members will receive an update on progress made to...

  16. 76 FR 72427 - President's National Security Telecommunications Advisory Committee

    Science.gov (United States)

    2011-11-23

    ... Telecommunications Advisory Committee AGENCY: National Protection and Programs Directorate, DHS. ACTION: Committee... Telecommunications Advisory Committee (NSTAC) will meet on Thursday, December 8, 2011. The meeting will be open to...) telecommunications policy. During the meeting, NSTAC members will receive feedback from the Department of Homeland...

  17. Pharmacological modification of multi-drug resistance (MDR) in vitro detected by a novel fluorometric microculture cytotoxicity assay. Reversal of resistance and selective cytotoxic actions of cyclosporin A and verapamil on MDR leukemia T-cells.

    Science.gov (United States)

    Larsson, R; Nygren, P

    1990-07-15

    A novel fluorometric microculture cytotoxicity assay (FMCA), based on measurements of fluorescein diacetate (FDA) hydrolysis and DNA staining by Hoechst 33342, was used for drug sensitivity testing and detection of resistance reversal in acute lymphoblastic leukemia (ALL) cell lines. The 72-hr assay was found to be sensitive, reproducible and linearly related to the number of viable cells within a broad range of cell concentrations. At clinically achievable drug concentrations, the calcium channel blocker Verapamil (ver) and the immunosuppressant Cyclosporin A (csA) were found to partly reverse acquired Vincristine (vcr) resistance in multi-drug resistant (MDR) T-ALL L100 cells with little or no effect on the drug-sensitive parental L0 cell line. By combining the fluorometric indices, we found that low concentrations of csA were growth-inhibitory, whereas higher concentrations (greater than 10 micrograms/ml) were progressively cytotoxic for drug-sensitive L0 cells. In MDR L100 cells, on the other hand, csA produced significant cell kill even at low drug concentrations. Ver had no effects on sensitive L0 cells but showed considerable cytotoxic action towards MDR L100 cells. There was no apparent relationship between drug reversal of vcr resistance and the cytotoxic actions of the drug per se since the calcium channel blocker diltiazem (dil) significantly potentiated the actions of vcr on MDR L100 cells without being more toxic to these cells (compared to vcr-sensitive L0 cells).

  18. Protective action of DNA preparations on the survival of cells and yield of 8-azaguanine resistant mutations in X-irradiated cell culture of chinese hamsters

    International Nuclear Information System (INIS)

    Kuznetsova, N.N.; Feoktistova, T.P.

    1976-01-01

    A DNA preparation (molecular weight 19.6-21.0x1O 6 daltons) administered to cell culture of Chinese hamsters in concentrations of 100 to 122 μg/ml 60 minutes before and in the course of 3 days after X-irradiation (600 R) decreased the lethality of irradiated cells and reduced induction of 8-azaguanine resistant genic mutations. DNA preparations with the concentrations under study had no toxic action on cells and were not mutagenous

  19. Vital Signs: Estimated Effects of a Coordinated Approach for Action to Reduce Antibiotic-Resistant Infections in Health Care Facilities - United States.

    Science.gov (United States)

    Slayton, Rachel B; Toth, Damon; Lee, Bruce Y; Tanner, Windy; Bartsch, Sarah M; Khader, Karim; Wong, Kim; Brown, Kevin; McKinnell, James A; Ray, William; Miller, Loren G; Rubin, Michael; Kim, Diane S; Adler, Fred; Cao, Chenghua; Avery, Lacey; Stone, Nathan T B; Kallen, Alexander; Samore, Matthew; Huang, Susan S; Fridkin, Scott; Jernigan, John A

    2015-08-07

    Treatments for health care-associated infections (HAIs) caused by antibiotic-resistant bacteria and Clostridium difficile are limited, and some patients have developed untreatable infections. Evidence-supported interventions are available, but coordinated approaches to interrupt the spread of HAIs could have a greater impact on reversing the increasing incidence of these infections than independent facility-based program efforts. Data from CDC's National Healthcare Safety Network and Emerging Infections Program were analyzed to project the number of health care-associated infections from antibiotic-resistant bacteria or C. difficile both with and without a large scale national intervention that would include interrupting transmission and improved antibiotic stewardship. As an example, the impact of reducing transmission of one antibiotic-resistant infection (carbapenem-resistant Enterobacteriaceae [CRE]) on cumulative prevalence and number of HAI transmission events within interconnected groups of health care facilities was modeled using two distinct approaches, a large scale and a smaller scale health care network. Immediate nationwide infection control and antibiotic stewardship interventions, over 5 years, could avert an estimated 619,000 HAIs resulting from CRE, multidrug-resistant Pseudomonas aeruginosa, invasive methicillin-resistant Staphylococcus aureus (MRSA), or C. difficile. Compared with independent efforts, a coordinated response to prevent CRE spread across a group of inter-connected health care facilities resulted in a cumulative 74% reduction in acquisitions over 5 years in a 10-facility network model, and 55% reduction over 15 years in a 102-facility network model. With effective action now, more than half a million antibiotic-resistant health care-associated infections could be prevented over 5 years. Models representing both large and small groups of interconnected health care facilities illustrate that a coordinated approach to interrupting

  20. Concerted action of two avirulent spore effectors activates Reaction to Puccinia graminis 1 (Rpg1)-mediated cereal stem rust resistance

    Science.gov (United States)

    The barley stem rust resistance gene Reaction to Puccinia graminis 1 (Rpg1), encoding a receptor-like kinase, confers durable resistance to the stem rust pathogen Puccinia graminis f. sp. tritici. The fungal urediniospores form adhesion structures with the leaf epidermal cells within 1 h of inocula...

  1. 7 CFR 917.35 - Powers and duties of each commodity committee.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Powers and duties of each commodity committee. 917.35... duties of each commodity committee. Each commodity committee shall have the following powers and duties..., That the Peach and Pear Commodity Committee shall each approve actions under § 917.39 and make said...

  2. Executive committee

    Science.gov (United States)

    Xiao, Guoqing; Cai, Xiaohong; Ding, Dajun; Ma, Xinwen; Zhao, Yongtao

    2014-04-01

    ChairVice Chair Toshiyuki AzumaRoberto Rivarola Atomic, Molecular & Optical Physics LabUniversidad Nacional de Rosario and Advanced Science InstituteInstituto de Fisica Rosario RIKEN, JapanRosario, Argentina SecretaryMembers Dominique VernhetJoachim Burgdörfer, Austria Institut des NanoSciences de Paris Birgit Lohmann, Australia Université Pierre et Marie Curie Hossein Sadeghpour, USA Paris, FranceThomas Stöhlker, Germany Past ChairJim McCann, UK Barry DunningGuoqing Xiao, China Physics & AstronomyXiaohong Cai, China Rice University, HoustonXinwen Ma, China Texas, USAYongtao Zhao, China TreasurerFernando Martin, Spain Henrik CederquistLuis Mendez, Spain Alba Nova University CenterAnatoli Kheifets, Australia Stockholm University Stockholm, Sweden Details of the general committee are available in the PDF

  3. Chemotherapy of Rodent Malaria. Evaluation of Drug Action against Normal and Resistant Strains including Exo-Erythrocytic Stages.

    Science.gov (United States)

    1979-10-01

    quinoline-methanols and allied compounds Quinine and a variety of drugs with comparable structures retain their activity against malaria parasites that...E. E., Warhurst, D. C. and Peters, W. (1975). The chemotherapy of rodent malaria , XXI. Action of quinine and WR 122,455 (a 9-phenanthrene methanol) on...AD-RI35 058 CHEMOTHERAPY’OF RODENT MALARIA EVALUATION OF DRUG I/i ACTION AGAINST NORMAL R-.(U) LIVERPOQL SCHOOL OF TROPICAL MEDICINE ENGLAND) DEPT OF

  4. Bactericidal activity and mechanism of action of copper-sputtered flexible surfaces against multidrug-resistant pathogens.

    Science.gov (United States)

    Ballo, Myriam K S; Rtimi, Sami; Mancini, Stefano; Kiwi, John; Pulgarin, César; Entenza, José M; Bizzini, Alain

    2016-07-01

    Using direct current magnetron sputtering (DCMS), we generated flexible copper polyester surfaces (Cu-PES) and investigated their antimicrobial activity against a range of multidrug-resistant (MDR) pathogens including eight Gram-positive isolates (three methicillin-resistant Staphylococcus aureus [MRSA], four vancomycin-resistant enterococci, one methicillin-resistant Staphylococcus epidermidis) and four Gram-negative strains (one extended-spectrum β-lactamase-producing [ESBL] Escherichia coli, one ESBL Klebsiella pneumoniae, one imipenem-resistant Pseudomonas aeruginosa, and one ciprofloxacin-resistant Acinetobacter baumannii). Bactericidal activity (≥3 log10 CFU reduction of the starting inoculum) was reached within 15-30 min exposure to Cu-PES. Antimicrobial activity of Cu-PES persisted in the absence of oxygen and against both Gram-positive and Gram-negative bacteria containing elevated levels of catalases, indicating that reactive oxygen species (ROS) do not play a primary role in the killing process. The decrease in cell viability of MRSA ATCC 43300 and Enterococcus faecalis V583 correlated with the progressive loss of cytoplasmic membrane integrity both under aerobic and anaerobic conditions, suggesting that Cu-PES mediated killing is primarily induced by disruption of the cytoplasmic membrane function. Overall, we here present novel antimicrobial copper surfaces with improved stability and sustainability and provide further insights into their mechanism of killing.

  5. A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action.

    Science.gov (United States)

    Damiano, Vincenzo; Garofalo, Sonia; Rosa, Roberta; Bianco, Roberto; Caputo, Rosa; Gelardi, Teresa; Merola, Gerardina; Racioppi, Luigi; Garbi, Corrado; Kandimalla, Ekambar R; Agrawal, Sudhir; Tortora, Giampaolo

    2009-11-15

    Resistance to anti-HER2 monoclonal antibody trastuzumab is a relevant issue in breast cancer patients. Among the mechanisms implicated in trastuzumab resistance, increasing evidence supports a role of tumor microenvironment. We previously found that a novel toll-like receptor 9 agonist, referred to as immune modulatory oligonucleotide (IMO) and currently under clinical investigation, acts through epidermal growth factor receptor (EGFR) and shows direct antiangiogenic effects by cooperating with anti-EGFR or anti-VEGF drugs, thus interfering with cancer cells and microenvironment. In this study, we used KPL-4 and JIMT-1 trastuzumab-resistant breast cancer cells to evaluate the combination IMO plus trastuzumab as a therapeutic option for trastuzumab-resistant breast cancers. IMO inhibits KPL-4 and JIMT-1 xenografts growth and potentiates trastuzumab antitumor effect, with complete suppression of tumor growth, potent enhancement of trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity, and strong inhibition of EGFR/HER2-related signaling. In KPL-4 xenografts, IMO alone interferes with HER signal transduction, whereas trastuzumab is ineffective. IMO induces an HER-dependent signal inhibition also in vitro by modulating a functional interaction between toll-like receptor 9 and HER receptors occurring at membrane level. Finally, IMO plus trastuzumab produces a cooperative antiangiogenic effect related to suppression of endothelial HER-related signaling. We showed a cooperative effect of IMO plus trastuzumab in trastuzumab-resistant breast cancers due to IMO direct antitumor and antiangiogenic activity and antibody-dependent cell-mediated cytotoxicity enhancement. Moreover, we provided first evidence of a toll-like receptor 9/HER interaction at membrane level as novel mechanism of action. Altogether, we propose IMO plus trastuzumab as an effective strategy in trastuzumab-resistant breast cancers.

  6. Report of the Action Committee on Bioengineering.

    Science.gov (United States)

    Schein, Martin W.

    Bioengineering has been defined as "the application of knowledge gained by a cross fertilization of engineering and the biological sciences so that both will be more fully utilized for the benefit of mankind." Bioengineering has at least six areas of application: (1) medical engineering, (2) environmental health engineering, (3)…

  7. Glucagon-Like Peptide 1 Recruits Muscle Microvasculature and Improves Insulin’s Metabolic Action in the Presence of Insulin Resistance

    Science.gov (United States)

    Chai, Weidong; Zhang, Xingxing; Barrett, Eugene J.

    2014-01-01

    Glucagon-like peptide 1 (GLP-1) acutely recruits muscle microvasculature, increases muscle delivery of insulin, and enhances muscle use of glucose, independent of its effect on insulin secretion. To examine whether GLP-1 modulates muscle microvascular and metabolic insulin responses in the setting of insulin resistance, we assessed muscle microvascular blood volume (MBV), flow velocity, and blood flow in control insulin-sensitive rats and rats made insulin-resistant acutely (systemic lipid infusion) or chronically (high-fat diet [HFD]) before and after a euglycemic-hyperinsulinemic clamp (3 mU/kg/min) with or without superimposed systemic GLP-1 infusion. Insulin significantly recruited muscle microvasculature and addition of GLP-1 further expanded muscle MBV and increased insulin-mediated glucose disposal. GLP-1 infusion potently recruited muscle microvasculature in the presence of either acute or chronic insulin resistance by increasing muscle MBV. This was associated with an increased muscle delivery of insulin and muscle interstitial oxygen saturation. Muscle insulin sensitivity was completely restored in the presence of systemic lipid infusion and significantly improved in rats fed an HFD. We conclude that GLP-1 infusion potently expands muscle microvascular surface area and improves insulin’s metabolic action in the insulin-resistant states. This may contribute to improved glycemic control seen in diabetic patients receiving incretin-based therapy. PMID:24658303

  8. The influence of muscle action on heart rate, RPE, and affective responses after upper-body resistance exercise.

    Science.gov (United States)

    Miller, Paul C; Hall, Eric E; Chmelo, Elizabeth A; Morrison, Jeffrey M; DeWitt, Rachel E; Kostura, Christine M

    2009-03-01

    Ratings of perceived exertion (RPE) are routinely used to monitor, assess, and prescribe aerobic exercise. Heart rate (HR) is another measure used to evaluate exercise intensity. Additionally, affective responses to aerobic exercise have been studied and seem to be influenced by the intensity of the exercise. The perceptual, HR, and affective responses to resistance exercise have not been effectively established. The purpose of this study was to examine whether differences in affect, RPE, and HR exist among college-aged women (n = 31) performing three different modes of resistance training: concentric (CE), eccentric (EE), and traditional concentric/eccentric (TE) performed at varying resistances. The women were asked to complete four sessions of resistance training on variable resistance machines: chest press, seated row, overhead press, and biceps curl. The first session was used to establish the 10-repetition maximum (RM) load for each station. Subsequent sessions involved the execution of training in one of the three test conditions: CE, EE, or TE. The participants performed three sets of each lift at 80% 10-RM, 100% 10-RM, and 120% 10-RM. The data revealed lower RPE during EE than the other test conditions. Similarly, EE elicited more mild HR response than either CE or TE. This finding is potentially important for the establishment of training programs, especially for those individuals recovering from an illness, who had been previously sedentary, and who are involved in rehabilitation of an injury.

  9. 78 FR 1917 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2013-01-09

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to the...

  10. 77 FR 65443 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2012-10-26

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  11. 75 FR 51332 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2010-08-19

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  12. 76 FR 4743 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-01-26

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  13. 75 FR 52058 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2010-08-24

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee-Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section 10...

  14. 75 FR 38866 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2010-07-06

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  15. 76 FR 41323 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-07-13

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  16. 76 FR 67018 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-10-28

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  17. 76 FR 4988 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-01-27

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  18. 76 FR 621 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-01-05

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  19. 76 FR 12211 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-03-04

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference (COMSTAC). SUMMARY: Pursuant...

  20. 75 FR 71791 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2010-11-24

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  1. 76 FR 15041 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-03-18

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  2. 77 FR 48585 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2012-08-14

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

  3. 75 FR 16515 - NASA Advisory Council; Technology and Innovation Committee; Meeting.

    Science.gov (United States)

    2010-04-01

    ... of the Technology and Innovation Committee of the NASA Advisory Council (NAC). The Meeting will be... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-037)] NASA Advisory Council; Technology and Innovation Committee; Meeting. AGENCY: National Aeronautics and Space Administration. ACTION...

  4. 77 FR 27538 - Aviation Rulemaking Advisory Committee-Continuing a Task

    Science.gov (United States)

    2012-05-10

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Aviation Rulemaking Advisory Committee--Continuing a Task AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of continuing a task assignment for the Aviation Rulemaking Advisory Committee (ARAC). SUMMARY: The FAA assigned...

  5. 75 FR 39724 - Sixth Meeting-Special Committee 222: Inmarsat Aeronautical Mobile Satellite (Route) Services

    Science.gov (United States)

    2010-07-12

    ...: Inmarsat Aeronautical Mobile Satellite (Route) Services AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 222: Inmarsat Aeronautical Mobile Satellite (Route) Services... Committee 222: Inmarsat Aeronautical Mobile Satellite (Route) Services. DATES: The meeting will be held...

  6. 75 FR 15770 - Fifth Meeting-Special Committee 222: Inmarsat Aeronautical Mobile Satellite (Route) Services

    Science.gov (United States)

    2010-03-30

    ...: Inmarsat Aeronautical Mobile Satellite (Route) Services AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 222: Inmarsat Aeronautical Mobile Satellite (Route) Services... Committee 222: Inmarsat Aeronautical Mobile Satellite (Route) Services. DATES: The meeting will be held...

  7. 77 FR 13159 - Nanoscale Science, Engineering, and Technology Subcommittee of the Committee on Technology...

    Science.gov (United States)

    2012-03-05

    ... OFFICE OF SCIENCE AND TECHNOLOGY POLICY Nanoscale Science, Engineering, and Technology Subcommittee of the Committee on Technology, National Science and Technology Council Workshop ACTION: Notice of... Nanoscale Science, Engineering, and Technology (NSET) Subcommittee of the Committee on Technology, National...

  8. 75 FR 34418 - Notice of the Specialty Crop Committee's Stakeholder Listening Session

    Science.gov (United States)

    2010-06-17

    ... Notice of the Specialty Crop Committee's Stakeholder Listening Session AGENCY: Research, Education, and Economics, USDA. ACTION: Notice of stakeholder listening session. SUMMARY: The notice announces the Specialty Crop Committee's Stakeholder Listening Session. The document contained the wrong date for the...

  9. 77 FR 40323 - Notice of Invitation for Nominations to the Advisory Committee on Agriculture Statistics

    Science.gov (United States)

    2012-07-09

    ... DEPARTMENT OF AGRICULTURE National Agricultural Statistics Service Notice of Invitation for Nominations to the Advisory Committee on Agriculture Statistics AGENCY: National Agricultural Statistics Service (NASS), USDA. ACTION: Solicitation of Nominations to the Advisory Committee on Agriculture...

  10. 75 FR 34972 - Notice of Invitation for Nominations to the Advisory Committee on Agriculture Statistics

    Science.gov (United States)

    2010-06-21

    ... DEPARTMENT OF AGRICULTURE National Agricultural Statistics Service Notice of Invitation for Nominations to the Advisory Committee on Agriculture Statistics AGENCY: National Agricultural Statistics Service (NASS), USDA. ACTION: Solicitation of Nominations for Advisory Committee on Agriculture Statistics...

  11. 75 FR 5629 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2010-02-03

    ... Mr. Robert Hanisee, NASA Advisory Council, Audit, Finance, and Analysis Committee. Congressional... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-018)] NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION...

  12. Photodynamic action of LED-activated pyropheophorbide-α methyl ester in cisplatin-resistant human ovarian carcinoma cells

    Science.gov (United States)

    Tan, Y.; Xu, C. S.; Xia, X. S.; Yu, H. P.; Bai, D. Q.; He, Y.; Leung, A. W. N.

    2009-04-01

    Cisplatin-resistance is a major obstacle for the successful therapy to ovarian cancer, and exploring novel approach to deactivate cisplatin-resistant ovarian cells will improve the clinical outcomes. Our present study showed that there was no dark cytotoxicity of MPPa in the COC1/DDP cells at the dose of 0.25 - 4 μM, and LED-activated MPPa resulted in drug dose- and light-dependent cytotoxicity. Apoptotic rate 6 h after LED-activated MPPa (2 μM) increased to 16.71% under the light energy of 1 J/cm2. Confocal laser scanning microscopy showed that MPPa mainly localized in the intracellular membrane system, namely the endoplasmic reticulum, Golgi apparatus, lysosomes and mitochondria in the COC1/DDP cells. Mitochondrial membrane potential (ΔΨm) was collapsed when COC1/DDP cells were exposed to 2 μM MPPa for 20 h and then 1 J/cm2 irradiation of LED source. These data demonstrated that LED-activated MPPa significantly deactivated cisplatin-resistant ovarian cell line COC1/DDP cells and enhanced apoptosis and decreased ΔΨm, which suggests LED is an efficient light source for PDT and LED-activated MPPa can be developed as new modality for treating cisplatin-resistant ovarian.

  13. Points from the September Committee Meetings

    CERN Multimedia

    2002-01-01

    After a turbulent year, the Committee meetings during the week beginning 16th September took a calmer nature, even if the follow-up of the cost-to-completion review was still a central topic of discussion. The detailed Action Plan and timetable for implementing the recommendations of the External Review Committee were among the principle items. The Plan is based on actions that address specific recommendations, from the redeployment of staff to the LHC to improved financial controls and budgetary tools. It was well received by the Committees and will be presented to the full CERN Council in December. In the meantime, many actions are underway, such as the restructuring of the Accelerator Sector, and the establishment of an external committee to review costs and progress of the LHC on an annual basis. The Finance Committee examined the proposed budget for 2003, which will also be presented to Council for approval in December. In addition, the Committee approved the volume of Industrial Support contracts for 20...

  14. Disease resistance of Arabidopsis to Phytophthora brassicae is established by the sequential action of indole glucosinolates and camalexin.

    Science.gov (United States)

    Schlaeppi, Klaus; Abou-Mansour, Eliane; Buchala, Antony; Mauch, Felix

    2010-06-01

    We have analysed the role of tryptophan-derived secondary metabolites in disease resistance of Arabidopsis to the oomycete pathogen Phytophthora brassicae. Transcript analysis revealed that genes encoding enzymes involved in tryptophan, camalexin and indole glucosinolate (iGS) biosynthesis are coordinately induced in response to P. brassicae. However, a deficiency in either camalexin or iGS accumulation has only a minor effect on the disease resistance of Arabidopsis mutants. In contrast, the double mutant cyp79B2 cyp79B3, which has a blockage in the production of indole-3-aldoxime (IAOx), the common precursor of tryptophan-derived metabolites including camalexin and iGS, is highly susceptible to P. brassicae. Because cyp79B2 cyp79B3 shows no deficiencies in other tested disease resistance responses, we concluded that the lack of IAOx-derived compounds renders Arabidopsis susceptible despite wild-type-like pathogen-induced hypersensitive cell death, stress hormone signaling and callose deposition. The susceptibility of the double mutant pen2-1 pad3-1, which has a combined defect in camalexin synthesis and PEN2-catalysed hydrolysis of iGS compounds, demonstrates that both camalexin and products of iGS hydrolysis are important for disease resistance to P. brassicae. Products of iGS hydrolysis play an early defensive role, as indicated by enhanced epidermal penetration rates of Arabidopsis mutants affected in iGS synthesis or degradation. Our results show that disease resistance of Arabidopsis to P. brassicae is established by the sequential activity of the phytoanticipin iGS and the phytoalexin camalexin.

  15. RESULTS OF CALCULATION-EXPERIMENTAL INVESTIGATIONS OF ELECTRO-THERMAL RESISTIBILITY OF SHEET STEEL SAMPLES TO ACTION OF RATIONED COMPONENTS OF PULSED CURRENT OF ARTIFICIAL LIGHTING

    Directory of Open Access Journals (Sweden)

    M.I. Baranov

    2016-06-01

    Full Text Available Purpose. Calculation and experimental researches of the electro-thermal resistibility of the steel sheet samples to action standard pulse current components of the artificial lightning with amplitude-time parameters (ATP, corresponded the requirements of normative documents of USA for SAE ARP 5412 & SAE ARP 5416. Methodology. Electrophysics bases of technique of high tensions and large impulsive currents (LIC, and also scientific and technical bases of planning of devices of high-voltage impulsive technique and measuring in them LIC. Сurrent amplitude ImA=±200 kA (with a tolerance of ±10 %; current action integral JA=2∙106 A2•s (with a tolerance of ±20 %; time, corresponding to the amplitude of the current ImA, tmA≤50 microseconds; the duration of the current flow τpA≤500 microseconds. Results. The results of the evaluation of the calculated and experimental studies of electro-thermal resistance of the samples of plates measuring 0,5 m  0,5 m stainless steel 1 mm thickness to the action on them artificial lightning impulse currents with rationed ATP on the requirements of normative documents of USA for SAE ARP 5412 & SAE ARP 5416. A pulse A- component have a first amplitude 192 kA, the corresponding time of 34 μs, and the duration aperiodic component amplitude 804 A, corresponding to the time 9 ms. It has been shown that the long C- component current of artificial lightning can lead to keyhole these samples. The diameter of the holes in this thin steel sheet, which is formed during the flow of current C- components can reach 15 mm. The results of calculation and experiment agree within 28 %. Originality. For the first time in world practice on the generator large pulsed currents experimental studies of resistibility of sheet steel samples to the action of artificial lightning currents with critical parameters. Practical value. Using the results obtained in the practice of lightning protection will significantly improve the

  16. Concerted action of two avirulent spore effectors activates Reaction to Puccinia graminis 1 (Rpg1)-mediated cereal stem rust resistance.

    Science.gov (United States)

    Nirmala, Jayaveeramuthu; Drader, Tom; Lawrence, Paulraj K; Yin, Chuntao; Hulbert, Scot; Steber, Camille M; Steffenson, Brian J; Szabo, Les J; von Wettstein, Diter; Kleinhofs, Andris

    2011-08-30

    The barley stem rust resistance gene Reaction to Puccinia graminis 1 (Rpg1), encoding a receptor-like kinase, confers durable resistance to the stem rust pathogen Puccinia graminis f. sp. tritici. The fungal urediniospores form adhesion structures with the leaf epidermal cells within 1 h of inoculation, followed by hyphae and haustorium formation. The RPG1 protein is constitutively expressed and not phosphorylated. On inoculation with avirulent urediniospores, it is phosphorylated in vivo within 5 min and subsequently degraded. Application of arginine-glycine-aspartic acid peptide loops prevented the formation of adhesion structures for spore attachment, the phosphorylation of RPG1, and germination of the viable spores. Arginine-glycine-aspartic acid affinity chromatography of proteins from the ungerminated avirulent rust spores led to the purification and identification of a protein with fibronectin type III and breast cancer type 1 susceptibility protein domains and a vacuolar protein sorting-associated protein 9 with a coupling of ubiquitin to endoplasmic reticulum degradation domain. Both proteins are required to induce in vivo phosphorylation and degradation of RPG1. Combined application of both proteins caused hypersensitive reaction on the stem rust-resistant cultivar Morex but not on the susceptible cultivar Steptoe. Expression studies indicated that mRNA of both genes are present in ungerminated urediniospores and are constitutively transcribed in sporelings, infected leaves, and haustoria in the investigated avirulent races. Evidence is presented that RPG1, in yeast, interacts with the two protein effectors from the urediniospores that activate cooperatively the stem rust resistance protein RPG1 long before haustoria formation.

  17. Potential Mechanism of Action of 3′-Demethoxy-6-O-demethyl-isoguaiacin on Methicillin Resistant Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Juan Manuel J. Favela-Hernández

    2015-07-01

    Full Text Available Bacterial infections represent one of the main threats to global public health. One of the major causative agents associated with high morbidity and mortality infections in hospitals worldwide is methicillin-resistant Staphylococcus aureus. Therefore, there is a need to develop new antibacterial agents to treat these infections, and natural products are a rich source of them. In previous studies, we reported that lignan 3′-demethoxy-6-O-demethylisoguaiacin, isolated and characterized from Larrea tridentate, showed the best activity towards methicillin-resistant S. aureus. Thus, the aim of this study was to determine the potential molecular mechanism of the antibacterial activity of 3′-demethoxy-6-O-demethylisoguaiacin against methicillin-resistant S. aureus using microarray technology. Results of microarray genome expression were validated by real-time polymerase chain reaction (RT-PCR. The genetic profile expression results showed that lignan 3′-demethoxy-6-O-demethylisoguaiacin had activity on cell membrane affecting proteins of the ATP-binding cassette (ABC transport system causing bacteria death. This molecular mechanism is not present in any antibacterial commercial drug and could be a new target for the development of novel antibacterial agents.

  18. Potential Mechanism of Action of 3'-Demethoxy-6-O-demethyl-isoguaiacin on Methicillin Resistant Staphylococcus aureus.

    Science.gov (United States)

    Favela-Hernández, Juan Manuel J; Clemente-Soto, Aldo F; Balderas-Rentería, Isaías; Garza-González, Elvira; Camacho-Corona, María del Rayo

    2015-07-08

    Bacterial infections represent one of the main threats to global public health. One of the major causative agents associated with high morbidity and mortality infections in hospitals worldwide is methicillin-resistant Staphylococcus aureus. Therefore, there is a need to develop new antibacterial agents to treat these infections, and natural products are a rich source of them. In previous studies, we reported that lignan 3'-demethoxy-6-O-demethylisoguaiacin, isolated and characterized from Larrea tridentate, showed the best activity towards methicillin-resistant S. aureus. Thus, the aim of this study was to determine the potential molecular mechanism of the antibacterial activity of 3'-demethoxy-6-O-demethylisoguaiacin against methicillin-resistant S. aureus using microarray technology. Results of microarray genome expression were validated by real-time polymerase chain reaction (RT-PCR). The genetic profile expression results showed that lignan 3'-demethoxy-6-O-demethylisoguaiacin had activity on cell membrane affecting proteins of the ATP-binding cassette (ABC) transport system causing bacteria death. This molecular mechanism is not present in any antibacterial commercial drug and could be a new target for the development of novel antibacterial agents.

  19. Action of antibiotic oxacillin on in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) previously treated with homeopathic medicines.

    Science.gov (United States)

    Passeti, Tânia Aguiar; Bissoli, Leandro Ribeiro; Macedo, Ana Paula; Libame, Registila Beltrame; Diniz, Susana; Waisse, Silvia

    2017-02-01

    Resistance to antibiotics is a major public health concern worldwide. New treatment options are needed and homeopathy is one such option. We sought to assess the effect of the homeopathic medicine Belladonna (Bell) and a nosode (biotherapy) prepared from a multi-drug resistant bacterial species, methicillin-resistant Staphylococcus aureus (MRSA), on the same bacterium. Bell and MRSA nosode were prepared in 6cH and 30cH potencies in 30% alcohol and sterile water, according to the Brazilian Homeopathic Pharmacopeia and tested on MRSA National Collection of Type Cultures (NCTC) 10442. We assessed in vitro bacterial growth, deoxyribonuclease (DNAase) and hemolysin activity, and in vitro bacterial growth in combination with oxacillin (minimum inhibitory concentration - MIC). All values were compared to control: 30% alcohol and water. In vitro growth of MRSA was statistically significantly inhibited in the presence of Bell and nosode 6cH and 30cH compared to controls (p MRSA treated with Belladonna or MRSA nosode exhibited reduced growth in vitro, reduced enzymatic activity and became more vulnerable to the action of the antibiotic oxacillin. Further studies are needed on the biomolecular basis of these effects. Copyright © 2016 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.

  20. Action of Violence’ or ‘Democratic Protest’? According to the Turkish Press Gezi Park Resistance

    OpenAIRE

    Öztoprak, Meral; Özdeşim Subay, Özlem

    2018-01-01

    This retrospective study, an analysis of the texts,which appeared during the Gezi Park events in Turkey the pro-government andnon-pro-government press. The study prefers to use the quantitative contentanalysis method since it provides objective and systematic data in content ofthe communication. In this study, we focus on a one month period, starting fromthe 27th May 2013 as the first day of Gezi Park Resistance until the27th June 2013, of all published headlines of six different nationalnews...

  1. Synthetic (+)-antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities.

    Science.gov (United States)

    Hsu, C Y; Sulake, R S; Huang, P-K; Shih, H-Y; Sie, H-W; Lai, Y-K; Chen, C; Weng, C F

    2015-01-01

    The fungal product (+)-antroquinonol activates AMP kinase (AMPK) activity in cancer cell lines. The present study was conducted to examine whether chemically synthesized (+)-antroquinonol exhibited beneficial metabolic effects in insulin-resistant states by activating AMPK and inhibiting dipeptidyl peptidase IV (DPP IV) activity. Effects of (+)-antroquinonol on DPP IV activity were measured with a DPPIV Assay Kit and effects on GLP-1-induced PKA were measured in AR42J cells. Translocation of the glucose transporter 4, GLUT4, induced either by insulin-dependent PI3K/AKT signalling or by insulin-independent AMPK activation, was assayed in differentiated myotubes. Glucose uptake and GLUT4 translocation were assayed in L6 myocytes. Mice with diet-induced obesity were used to assess effects of acute and chronic treatment with (+)-antroquinonol on glycaemic control in vivo. The results showed that of (+)-antroquinonol (100 μM ) inhibited the DPP IV activity as effectively as the clinically used inhibitor, sitagliptin. The phosphorylation of AMPK Thr(172) in differentiated myotubes was significantly increased by (+)-antroquinonol. In cells simultaneously treated with S961 (insulin receptor antagonist), insulin and (+)-antroquinonol, the combination of (+)-antroquinonol plus insulin still increased both GLUT4 translocation and glucose uptake. Further, (+)-antroquinonol and sitagliptin reduced blood glucose, when given acutely or chronically to DIO mice. Chemically synthesized (+)-antroquinonol exhibits dual effects to ameliorate insulin resistance, by increasing AMPK activity and GLUT4 translocation, along with inhibiting DPP IV activity. © 2014 The British Pharmacological Society.

  2. Mode of Action Analyses of Neferine, a Bisbenzylisoquinoline Alkaloid of Lotus (Nelumbo nucifera against Multidrug-Resistant Tumor Cells

    Directory of Open Access Journals (Sweden)

    Onat Kadioglu

    2017-05-01

    Full Text Available Neferine, a bisbenzylisoquinoline alkaloid isolated from the green seed embryos of Lotus (Nelumbo nucifera Gaertn, has been previously shown to have various anti-cancer effects. In the present study, we evaluated the effect of neferine in terms of P-glycoprotein (P-gp inhibition via in vitro cytotoxicity assays, R123 uptake assays in drug-resistant cancer cells, in silico molecular docking analysis on human P-gp and in silico absorption, distribution, metabolism, and excretion (ADME, quantitative structure activity relationships (QSAR and toxicity analyses. Lipinski rule of five were mainly considered for the ADME evaluation and the preset descriptors including number of hydrogen bond donor, acceptor, hERG IC50, logp, logD were considered for the QSAR analyses. Neferine revealed higher toxicity toward paclitaxel- and doxorubicin-resistant breast, lung or colon cancer cells, implying collateral sensitivity of these cells toward neferine. Increased R123 uptake was observed in a comparable manner to the control P-gp inhibitor, verapamil. Molecular docking analyses revealed that neferine still interacts with P-gp, even if R123 was pre-bound. Bioinformatical ADME and toxicity analyses revealed that neferine possesses the druggability parameters with no predicted toxicity. In conclusion, neferine may allocate the P-gp drug-binding pocket and prevent R123 binding in agreement with P-gp inhibition experiments, where neferine increased R123 uptake.

  3. The Audit Committee. AGB Effective Committee Series

    Science.gov (United States)

    Staisloff, Richard L.

    2011-01-01

    This publication is part of an Association of Governing Boards of Universities and Colleges (AGB) series devoted to strengthening the role of key standing committees of governing boards. While there is no optimum committee system for institutions of higher education, certain principles, practices, and procedures prevail. The best practices…

  4. Dual Action of Lysophosphatidate-Functionalised Titanium: Interactions with Human (MG63) Osteoblasts and Methicillin Resistant Staphylococcus aureus

    DEFF Research Database (Denmark)

    Skindersø, Mette Elena; Krogfelt, Karen Angeliki; Blom, Ashley

    2015-01-01

    Titanium (Ti) is a widely used material for surgical implants; total joint replacements (TJRs), screws and plates for fixing bones and dental implants are forged from Ti. Whilst Ti integrates well into host tissue approximately 10% of TJRs will fail in the lifetime of the patient through a proces...... of Staphylococcus aureus, a bacterium often associated with implant failures through sepsis. Collectively we provide evidence for the fabrication of a dual-action Ti surface finish, a highly desirable feature towards the development of next-generation implantable devices....... known as aseptic loosening. These failures necessitate revision arthroplasties which are more complicated and costly than the initial procedure. Finding ways of enhancing early (osseo)integration of TJRs is therefore highly desirable and continues to represent a research priority in current biomaterial...

  5. A novel thermal decomposition approach to synthesize hydroxyapatite-silver nanocomposites and their antibacterial action against GFP-expressing antibiotic resistant E. coli.

    Science.gov (United States)

    Sahni, Geetika; Gopinath, P; Jeevanandam, P

    2013-03-01

    A novel thermal decomposition approach to synthesize hydroxyapatite-silver (Hap-Ag) nanocomposites has been reported. The nanocomposites were characterized by X-ray diffraction, field emission scanning electron microscopy coupled with energy dispersive X-ray analysis, transmission electron microscopy and diffuse reflectance spectroscopy techniques. Antibacterial activity studies for the nanocomposites were explored using a new rapid access method employing recombinant green fluorescent protein (GFP) expressing antibiotic resistant Escherichia coli (E. coli). The antibacterial activity was studied by visual turbidity analysis, optical density analysis, fluorescence spectroscopy and microscopy. The mechanism of bactericidal action of the nanocomposites on E. coli was investigated using atomic force microscopy, and TEM analysis. Excellent bactericidal activity at low concentration of the nanocomposites was observed which may allow their use in the production of microbial contamination free prosthetics. Copyright © 2012 Elsevier B.V. All rights reserved.

  6. American Samoa: Energy Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    Ness, J. Erik [National Renewable Energy Lab. (NREL), Golden, CO (United States); Haase, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Conrad, Misty [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-09-01

    This document outlines actions being taken to reduce American Samoa's petroleum consumption. It describes the four near-term strategies selected by the American Samoa Renewable Energy Committee during action-planning workshops conducted in May 2016, and describes the steps that will need to be taken to implement those strategies.

  7. Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves.

    Science.gov (United States)

    Klein, Amanda H; Vyshnevska, Alina; Hartke, Timothy V; De Col, Roberto; Mankowski, Joseph L; Turnquist, Brian; Bosmans, Frank; Reeh, Peter W; Schmelz, Martin; Carr, Richard W; Ringkamp, Matthias

    2017-05-17

    Voltage-gated sodium (Na V ) channels are responsible for the initiation and conduction of action potentials within primary afferents. The nine Na V channel isoforms recognized in mammals are often functionally divided into tetrodotoxin (TTX)-sensitive (TTX-s) channels (Na V 1.1-Na V 1.4, Na V 1.6-Na V 1.7) that are blocked by nanomolar concentrations and TTX-resistant (TTX-r) channels (Na V 1.8 and Na V 1.9) inhibited by millimolar concentrations, with Na V 1.5 having an intermediate toxin sensitivity. For small-diameter primary afferent neurons, it is unclear to what extent different Na V channel isoforms are distributed along the peripheral and central branches of their bifurcated axons. To determine the relative contribution of TTX-s and TTX-r channels to action potential conduction in different axonal compartments, we investigated the effects of TTX on C-fiber-mediated compound action potentials (C-CAPs) of proximal and distal peripheral nerve segments and dorsal roots from mice and pigtail monkeys ( Macaca nemestrina ). In the dorsal roots and proximal peripheral nerves of mice and nonhuman primates, TTX reduced the C-CAP amplitude to 16% of the baseline. In contrast, >30% of the C-CAP was resistant to TTX in distal peripheral branches of monkeys and WT and Na V 1.9 -/- mice. In nerves from Na V 1.8 -/- mice, TTX-r C-CAPs could not be detected. These data indicate that Na V 1.8 is the primary isoform underlying TTX-r conduction in distal axons of somatosensory C-fibers. Furthermore, there is a differential spatial distribution of Na V 1.8 within C-fiber axons, being functionally more prominent in the most distal axons and terminal regions. The enrichment of Na V 1.8 in distal axons may provide a useful target in the treatment of pain of peripheral origin. SIGNIFICANCE STATEMENT It is unclear whether individual sodium channel isoforms exert differential roles in action potential conduction along the axonal membrane of nociceptive, unmyelinated peripheral nerve

  8. Advisory Committee Handbook.

    Science.gov (United States)

    Black Hawk Coll., Moline, IL.

    An advisory committee is generally comprised of persons outside the education profession who have specialized knowledge in a given area. The committee advises, makes recommendations, and gives service to the college and its students, instructors, and administrators. At Black Hawk College, there are four types of advisory committees: community,…

  9. 77 FR 61432 - NASA Advisory Council; Aeronautics Committee; Meeting

    Science.gov (United States)

    2012-10-09

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-080] NASA Advisory Council; Aeronautics Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Meeting. SUMMARY... Aeronautics and Space Administration announces a meeting of the Aeronautics Committee of the NASA Advisory...

  10. 78 FR 9724 - Invasive Species Advisory Committee; Meetings

    Science.gov (United States)

    2013-02-11

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee; Meetings AGENCY: Office of the Secretary, Interior. ACTION: Notice of public meetings of the Invasive Species... hereby given of meetings of the Invasive Species Advisory Committee (ISAC). Comprised of 31 nonfederal...

  11. 75 FR 4576 - Veterinary Medicine Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2010-01-28

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Veterinary Medicine Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food an...

  12. 76 FR 14027 - Antiviral Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-03-15

    ...] Antiviral Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION... Administration (FDA). The meeting will be open to the public. Name of Committee: Antiviral Drugs Advisory... liver disease who are previously untreated or who have failed previous therapy. Compensated liver...

  13. 76 FR 14026 - Antiviral Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-03-15

    ...] Antiviral Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION... Administration (FDA). The meeting will be open to the public. Name of Committee: Antiviral Drugs Advisory... who are previously untreated or who have failed previous therapy. Compensated liver disease is a stage...

  14. 75 FR 81283 - Oncologic Drugs Advisory Committee; Cancellation

    Science.gov (United States)

    2010-12-27

    ... HUMAN SERVICES Food and Drug Administration Oncologic Drugs Advisory Committee; Cancellation AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The meeting of the Oncologic Drugs Advisory... of December 6, 2010 (75 FR 75680). On February 9, 2011, the Oncologic Drugs Advisory Committee was...

  15. 77 FR 63839 - Oncologic Drugs Advisory Committee; Cancellation

    Science.gov (United States)

    2012-10-17

    ... HUMAN SERVICES Food and Drug Administration Oncologic Drugs Advisory Committee; Cancellation AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The meeting of the Oncologic Drugs Advisory... committee have been resolved. FOR FURTHER INFORMATION CONTACT: Caleb Briggs, Center for Drug Evaluation and...

  16. 76 FR 11489 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-03-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0002] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  17. 76 FR 65736 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-10-24

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0002] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  18. 76 FR 44595 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-07-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0002] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  19. 75 FR 75680 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2010-12-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-N-0001] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  20. 76 FR 20309 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2011-04-12

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee (RAC) will meet on May 9, 2011 at the City of Sonora Fire Department, in Sonora...

  1. 76 FR 36898 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2011-06-23

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of Meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee will meet on July 11, 2011 at the City of Sonora Fire Department, in Sonora, California...

  2. 76 FR 46722 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2011-08-03

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee (RAC) will meet on August 15, 2011 at the City of Sonora Fire Department, in Sonora...

  3. 77 FR 48496 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2012-08-14

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee will meet on September 17, 2012 at the City of Sonora Fire Department, in Sonora...

  4. 76 FR 31935 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2011-06-02

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of Meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee will meet on June 13, 2011 at the City of Sonora Fire Department, in Sonora, California...

  5. 75 FR 30771 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2010-06-02

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee will meet on June 14, 2010, at the City of Sonora Fire Department, in Sonora, California...

  6. 77 FR 48495 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2012-08-14

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee will meet on September 10, 2012 at the City of Sonora Fire Department, in Sonora...

  7. 75 FR 33241 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2010-06-11

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee will meet on June 14, 2010 at the City of Sonora Fire Department, in Sonora, California...

  8. 76 FR 7809 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2011-02-11

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource.... The purpose of the meeting is to convene the Tuolumne-Mariposa Counties Resource Advisory Committee...

  9. 75 FR 23222 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2010-05-03

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee (RAC) will meet on May 17, 2010 at the City of Sonora Fire Department, in Sonora...

  10. 75 FR 38771 - Tuolumne-Mariposa Counties Resource Advisory Committee

    Science.gov (United States)

    2010-07-06

    ... DEPARTMENT OF AGRICULTURE Forest Service Tuolumne-Mariposa Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tuolumne-Mariposa Counties Resource Advisory Committee will meet on August 16, 2010 at the City of Sonora Fire Department, in Sonora...

  11. 77 FR 32125 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-05-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  12. 77 FR 25184 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-04-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  13. 77 FR 5813 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-02-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  14. 78 FR 57166 - Antiviral Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-09-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001] Antiviral Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  15. 75 FR 9419 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2010-03-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-N-0001] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  16. 78 FR 13348 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-02-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  17. 78 FR 48690 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-08-09

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  18. 77 FR 31025 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-05-24

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  19. 76 FR 82309 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-12-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0002] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  20. 76 FR 82310 - Oncologic Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-12-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-N-0002] Oncologic Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug...

  1. 77 FR 50702 - Cardiovascular and Renal Drugs Advisory Committee; Cancellation

    Science.gov (United States)

    2012-08-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Cardiovascular and Renal Drugs Advisory Committee; Cancellation AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The meeting of the Cardiovascular and Renal Drugs Advisory Committee scheduled for...

  2. 76 FR 5380 - Advisory Committees; Filing of Closed Meeting Reports

    Science.gov (United States)

    2011-01-31

    ...] Advisory Committees; Filing of Closed Meeting Reports AGENCY: Food and Drug Administration, HHS. ACTION... Advisory Committee Act, the Agency has filed with the Library of Congress the annual reports of those FDA...), FDA has filed with the Library of Congress the annual reports for the following FDA advisory...

  3. 76 FR 62418 - Antiviral Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-10-07

    ...] Antiviral Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION... Administration (FDA). The meeting will be open to the public. Name of Committee: Antiviral Drugs Advisory... enter through Building 1. Contact Person: Paul Tran, Center for Drug Evaluation and Research, Food and...

  4. 75 FR 16151 - Antiviral Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2010-03-31

    ...] Antiviral Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION... Administration (FDA). The meeting will be open to the public. Name of Committee: Antiviral Drugs Advisory... phone number is 301-589- 5200. Contact Person: Paul Tran, Center for Drug Evaluation and Research (HFD...

  5. 77 FR 15110 - Antiviral Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-03-14

    ...] Antiviral Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION... Administration (FDA). The meeting will be open to the public. Name of Committee: Antiviral Drugs Advisory... enter through Building 1. Contact Person: Yvette Waples, Center for Drug Evaluation and Research, Food...

  6. 78 FR 56900 - Antiviral Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-09-16

    ...] Antiviral Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION... Administration (FDA). The meeting will be open to the public. Name of Committee: Antiviral Drugs Advisory..., Center for Drug Evaluation and Research, 10903 New Hampshire Ave., Bldg. 31, Rm. 2417, Silver Spring, MD...

  7. 77 FR 17487 - Antiviral Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-03-26

    ...] Antiviral Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION... Administration (FDA). The meeting will be open to the public. Name of Committee: Antiviral Drugs Advisory... Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 31, Rm. 2417, Silver...

  8. 76 FR 71033 - Federal Advisory Committee Act; Technological Advisory Council

    Science.gov (United States)

    2011-11-16

    ... COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In accordance with the Federal Advisory Committee Act... Advisory Council will hold a meeting on Tuesday, December 20, 2011 in the Commission Meeting Room, from 1 p...

  9. 78 FR 12059 - Federal Advisory Committee Act; Technological Advisory Council

    Science.gov (United States)

    2013-02-21

    ... COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications Commission. ] ACTION: Notice of public meeting. SUMMARY: In accordance with the Federal Advisory Committee...) Technological Advisory Council will hold a meeting on Monday, March 11, 2013 in the Commission Meeting Room...

  10. 77 FR 30289 - Federal Advisory Committee Act; Technological Advisory Council

    Science.gov (United States)

    2012-05-22

    ... COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In accordance with the Federal Advisory Committee Act... Advisory Council will hold a meeting on Wednesday, June 27, 2012 in the Commission Meeting Room, from 1 p.m...

  11. 77 FR 12839 - Federal Advisory Committee Act; Technological Advisory Council

    Science.gov (United States)

    2012-03-02

    ... COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In accordance with the Federal Advisory Committee Act... Advisory Council will hold a meeting on Wednesday, March 28, 2012 in the Commission Meeting Room, from 1 p...

  12. 78 FR 55255 - Federal Advisory Committee Act; Technological Advisory Council

    Science.gov (United States)

    2013-09-10

    ... COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In accordance with the Federal Advisory Committee Act... Advisory Council (TAC) will hold a meeting in the Commission Meeting Room to discuss progress on work...

  13. 78 FR 67362 - Federal Advisory Committee Act; Technological Advisory Council

    Science.gov (United States)

    2013-11-12

    ... COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In accordance with the Federal Advisory Committee Act... Advisory Council will hold a meeting on Monday, December 9, 2013 in the Commission Meeting Room, from 1 p.m...

  14. 77 FR 52332 - Federal Advisory Committee Act; Technological Advisory Council

    Science.gov (United States)

    2012-08-29

    ... COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In accordance with the Federal Advisory Committee Act... Advisory Council will hold a meeting on Monday, September 24, 2012 in the Commission Meeting Room, from 1 p...

  15. 76 FR 14009 - Federal Advisory Committee Act; Technological Advisory Council

    Science.gov (United States)

    2011-03-15

    ... COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications Commission. ACTION: Notice of public meeting. SUMMARY: In accordance with the Federal Advisory Committee Act... Advisory Council will hold a meeting on Wednesday, March 30, 2011 in the Commission Meeting Room, from 1 p...

  16. 76 FR 59186 - Renewal of Rail Energy Transportation Advisory Committee

    Science.gov (United States)

    2011-09-23

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. EP 670 (Sub-No. 3)] Renewal of Rail Energy Transportation Advisory Committee AGENCY: Surface Transportation Board. ACTION: Notice...) intends to renew the charter of the Rail Energy Transportation Advisory Committee (RETAC). ADDRESSES: A...

  17. 78 FR 58383 - Renewal of Rail Energy Transportation Advisory Committee

    Science.gov (United States)

    2013-09-23

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. EP 670 (Sub-No. 3)] Renewal of Rail Energy Transportation Advisory Committee AGENCY: Surface Transportation Board, DOT. ACTION...) intends to renew the charter of the Rail Energy Transportation Advisory Committee (RETAC). ADDRESSES: A...

  18. 78 FR 8109 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2013-02-05

    ....S. Geological Survey (USGS) Scientific Earthquake Studies Advisory Committee (SESAC) serves in an ex... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction...

  19. 76 FR 8712 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2011-02-15

    ... (USGS) Scientific Earthquake Studies Advisory Committee (SESAC) serves in an ex officio capacity on the... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction...

  20. 75 FR 18787 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2010-04-13

    ... (USGS) Scientific Earthquake Studies Advisory Committee (SESAC) serves in an ex-officio capacity on the... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction...

  1. 75 FR 75457 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2010-12-03

    ... (USGS) Scientific Earthquake Studies Advisory Committee (SESAC) serves in an ex-officio capacity on the... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction...

  2. 75 FR 8042 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2010-02-23

    ... (USGS) Scientific Earthquake Studies Advisory Committee (SESAC) serves in an ex officio capacity on the... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction...

  3. 78 FR 37820 - Nonprescription Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-06-24

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001] Nonprescription Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION... Administration (FDA). The meeting will be open to the public. Name of Committee: Nonprescription Drugs Advisory...

  4. 78 FR 66011 - Allergenic Products Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-11-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001] Allergenic Products Advisory Committee; Notice of Meeting AGENCY: Food and Drug Administration, HHS. ACTION... Administration (FDA). The meeting will be open to the public. Name of Committee: Allergenic Products Advisory...

  5. Evaluation of fasting plasma insulin concentration as an estimate of insulin action in nondiabetic individuals: comparison with the homeostasis model assessment of insulin resistance (HOMA-IR).

    Science.gov (United States)

    Abbasi, Fahim; Okeke, QueenDenise; Reaven, Gerald M

    2014-04-01

    Insulin-mediated glucose disposal varies severalfold in apparently healthy individuals, and approximately one-third of the most insulin resistant of these individuals is at increased risk to develop various adverse clinical syndromes. Since direct measurements of insulin sensitivity are not practical in a clinical setting, several surrogate estimates of insulin action have been proposed, including fasting plasma insulin (FPI) concentration and the homeostasis model assessment of insulin resistance (HOMA-IR) calculated by a formula employing fasting plasma glucose (FPG) and FPI concentrations. The objective of this study was to compare FPI as an estimate of insulin-mediated glucose disposal with values generated by HOMA-IR in 758 apparently healthy nondiabetic individuals. Measurements were made of FPG, FPI, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) concentrations, and insulin-mediated glucose uptake was quantified by determining steady-state plasma glucose (SSPG) concentration during the insulin suppression test. FPI and HOMA-IR were highly correlated (r = 0.98, P HOMA-IR (r = 0.64). Furthermore, the relationship between FPI and TG (r = 0.35) and HDL-C (r = -0.40) was comparable to that between HOMA-IR and TG (r = 0.39) and HDL-C (r = -0.41). In conclusion, FPI and HOMA-IR are highly correlated in nondiabetic individuals, with each estimate accounting for ~40% of the variability (variance) in a direct measure of insulin-mediated glucose disposal. Calculation of HOMA-IR does not provide a better surrogate estimate of insulin action, or of its associated dyslipidemia, than measurement of FPI.

  6. Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli.

    Science.gov (United States)

    Eumkeb, G; Siriwong, S; Phitaktim, S; Rojtinnakorn, N; Sakdarat, S

    2012-01-01

    The smaller galangal is extracted, purified and identified the bioactive compounds. The purpose of this research was to investigate whether these isolated compounds have antibacterial and synergistic activity against amoxicillin-resistant Escherichia coli (AREC) when used singly and in combination with amoxicillin. The primarily mode of action is also studied. The galangin, kaempferide and kaempferide-3-O-β-d-glucoside were isolated. The minimum inhibitory concentrations(MIC) of amoxicillin and these flavonoids against AREC were between 500 and >1000 μg ml(-1). Synergistic activity was observed on combining amoxicillin with these flavonoids. The combinations of amoxicillin and these flavonoids exhibited a synergistic effect, reducing AREC cell numbers. Electron microscopy showed that these combinations damaged the ultrastructure of AREC cells. The results indicated that these combinations altered outer membrane permeability but not affecting cytoplasmic membrane. Enzyme assays showed that these flavonoids had an inhibitory activity against penicillinase. These results indicated that these flavonoids have the potential to reverse bacterial resistance to amoxicillin in AREC and may operate via three mechanisms: inhibition of peptidoglycan and ribosome synthesis, alteration of outer membrane permeability, and interaction with β-lactamases. These findings offer the potential to develop a new generation of phytopharmaceuticals to treat AREC. © 2011 The Authors. Journal of Applied Microbiology © 2011 The Society for Applied Microbiology.

  7. 76 FR 66912 - Environmental Technologies Trade Advisory Committee Public Meeting

    Science.gov (United States)

    2011-10-28

    ... DEPARTMENT OF COMMERCE International Trade Administration Environmental Technologies Trade Advisory Committee Public Meeting AGENCY: International Trade Administration, DOC. ACTION: Notice of... DeLelle, Office of Energy & Environmental Industries (OEEI), International Trade Administration, Room 4053...

  8. 78 FR 21911 - Environmental Technologies Trade Advisory Committee Public Meeting

    Science.gov (United States)

    2013-04-12

    ... DEPARTMENT OF COMMERCE International Trade Administration Environmental Technologies Trade Advisory Committee Public Meeting AGENCY: International Trade Administration, DOC. ACTION: Notice of... Energy & Environmental Industries (OEEI), International Trade Administration, Room 4053, 1401...

  9. 78 FR 46921 - Environmental Technologies Trade Advisory Committee Public Meeting

    Science.gov (United States)

    2013-08-02

    ... DEPARTMENT OF COMMERCE International Trade Administration Environmental Technologies Trade Advisory Committee Public Meeting AGENCY: International Trade Administration, DOC. ACTION: Notice of... Hinman, Office of Energy & Environmental Industries (OEEI), International Trade Administration, Room 4053...

  10. 78 FR 4834 - Environmental Technologies Trade Advisory Committee Public Meeting

    Science.gov (United States)

    2013-01-23

    ... DEPARTMENT OF COMMERCE International Trade Administration Environmental Technologies Trade Advisory Committee Public Meeting AGENCY: International Trade Administration, Commerce. ACTION: Notice of... Energy & Environmental Industries (OEEI), International Trade Administration, Room 4053, 1401...

  11. 76 FR 51001 - Environmental Technologies Trade Advisory Committee Public Meeting

    Science.gov (United States)

    2011-08-17

    ... DEPARTMENT OF COMMERCE International Trade Administration Environmental Technologies Trade Advisory Committee Public Meeting AGENCY: International Trade Administration, DOC. ACTION: Notice of... Energy & Environmental Industries (OEEI), International Trade Administration, Room 4053, 1401...

  12. 77 FR 58356 - Environmental Technologies Trade Advisory Committee Public Meeting

    Science.gov (United States)

    2012-09-20

    ... DEPARTMENT OF COMMERCE International Trade Administration Environmental Technologies Trade Advisory Committee Public Meeting AGENCY: International Trade Administration, DOC. ACTION: Notice of... Energy & Environmental Industries (OEEI), International Trade Administration, Room 4053, 1401...

  13. 78 FR 21909 - Environmental Technologies Trade Advisory Committee; Public Meeting

    Science.gov (United States)

    2013-04-12

    ... DEPARTMENT OF COMMERCE International Trade Administration Environmental Technologies Trade Advisory Committee; Public Meeting AGENCY: International Trade Administration, DOC. ACTION: Notice of... DeLelle, Office of Energy & Environmental Industries (OEEI), International Trade Administration, Room 4053...

  14. 78 FR 63963 - Environmental Technologies Trade Advisory Committee Public Meeting

    Science.gov (United States)

    2013-10-25

    ... DEPARTMENT OF COMMERCE International Trade Administration Environmental Technologies Trade Advisory Committee Public Meeting AGENCY: International Trade Administration, DOC. ACTION: Notice of... Hinman, Office of Energy & Environmental Industries (OEEI), International Trade Administration, Room 4053...

  15. 77 FR 47814 - Florida National Forests Resource Advisory Committee

    Science.gov (United States)

    2012-08-10

    ... DEPARTMENT OF AGRICULTURE Forest Service Florida National Forests Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Florida National Forests Resource... to provide advice and recommendations to the Forest Service concerning projects and funding...

  16. 78 FR 59005 - Civil Nuclear Trade Advisory Committee Meeting

    Science.gov (United States)

    2013-09-25

    ... ability to participate in the international market. Topics to be considered: The agenda for the October 16... DEPARTMENT OF COMMERCE International Trade Administration Civil Nuclear Trade Advisory Committee Meeting AGENCY: International Trade Administration (ITA), Commerce (DOC). ACTION: Notice of federal...

  17. 76 FR 61666 - Collaborative Forest Landscape Restoration Program Advisory Committee

    Science.gov (United States)

    2011-10-05

    ... Forest Service Collaborative Forest Landscape Restoration Program Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Collaborative Forest Landscape Restoration Program... members. However, persons who wish to bring Collaborative Forest Landscape Restoration Program matters to...

  18. 75 FR 38456 - Collaborative Forest Landscape Restoration Program Advisory Committee

    Science.gov (United States)

    2010-07-02

    ... Forest Service Collaborative Forest Landscape Restoration Program Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Collaborative Forest Landscape Restoration Program..., persons who wish to bring Collaborative Forest Landscape Restoration Program matters to the attention of...

  19. 78 FR 72141 - Aviation Rulemaking Advisory Committee; Meeting

    Science.gov (United States)

    2013-12-02

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Aviation Rulemaking Advisory Committee; Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Aviation Rulemaking... the Federal Aviation Administration, 800 Independence Avenue SW., Washington, DC 20591, 10th floor...

  20. 77 FR 59592 - Visiting Committee on Advanced Technology

    Science.gov (United States)

    2012-09-28

    ... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Visiting Committee on Advanced Technology AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of public meeting. [[Page 59593

  1. 76 FR 12887 - Wholesale Pork Reporting Negotiated Rulemaking Committee

    Science.gov (United States)

    2011-03-09

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 59 Wholesale Pork Reporting Negotiated Rulemaking Committee AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice of negotiated rulemaking... at the Radisson Hotel Reagan National Airport, 2020 Jefferson Davis Highway, Arlington VA 22202...

  2. 78 FR 16757 - First Meeting: RTCA Tactical Operations Committee (TOC)

    Science.gov (United States)

    2013-03-18

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration First Meeting: RTCA Tactical Operations Committee (TOC) AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation... FAA Task Groups Discussion Anticipated Issues for TOC consideration and action at the next meeting...

  3. 78 FR 40264 - First Meeting: RTCA Tactical Operations Committee (TOC)

    Science.gov (United States)

    2013-07-03

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration First Meeting: RTCA Tactical Operations Committee (TOC) AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation..., Leadership Anticipated Issues for TOC consideration and action at the next meeting. Any Other Business...

  4. 75 FR 68008 - Business and Operations Advisory Committee

    Science.gov (United States)

    2010-11-04

    ... Changing Workplace: Challenges in a Federal Context (Discussion Continued); International Facilities... NATIONAL SCIENCE FOUNDATION Business and Operations Advisory Committee ACTION: Change in Notice of... business operations. Agenda November 16, 2010 Welcome/Introductions; BFA Update; The Changing Workplace...

  5. 77 FR 6783 - Renewable Energy and Energy Efficiency Advisory Committee

    Science.gov (United States)

    2012-02-09

    ... DEPARTMENT OF COMMERCE International Trade Administration Renewable Energy and Energy Efficiency Advisory Committee AGENCY: International Trade Administration, U.S. Department of Commerce. ACTION: Notice... competitiveness of U.S. renewable [[Page 6784

  6. 77 FR 2765 - NASA International Space Station Advisory Committee; Meeting

    Science.gov (United States)

    2012-01-19

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-003)] NASA International Space Station Advisory Committee; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of..., the National Aeronautics and Space Administration announces an open meeting of the NASA International...

  7. 76 FR 18165 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2011-04-01

    ....S. Geological Survey (USGS) Scientific Earthquake Studies Advisory Committee (SESAC) serves in an ex... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. [[Page 18166

  8. Dual Action of Lysophosphatidate-Functionalised Titanium: Interactions with Human (MG63 Osteoblasts and Methicillin Resistant Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    Mette Elena Skindersoe

    Full Text Available Titanium (Ti is a widely used material for surgical implants; total joint replacements (TJRs, screws and plates for fixing bones and dental implants are forged from Ti. Whilst Ti integrates well into host tissue approximately 10% of TJRs will fail in the lifetime of the patient through a process known as aseptic loosening. These failures necessitate revision arthroplasties which are more complicated and costly than the initial procedure. Finding ways of enhancing early (osseointegration of TJRs is therefore highly desirable and continues to represent a research priority in current biomaterial design. One way of realising improvements in implant quality is to coat the Ti surface with small biological agents known to support human osteoblast formation and maturation at Ti surfaces. Lysophosphatidic acid (LPA and certain LPA analogues offer potential solutions as Ti coatings in reducing aseptic loosening. Herein we present evidence for the successful bio-functionalisation of Ti using LPA. This modified Ti surface heightened the maturation of human osteoblasts, as supported by increased expression of alkaline phosphatase. These functionalised surfaces also deterred the attachment and growth of Staphylococcus aureus, a bacterium often associated with implant failures through sepsis. Collectively we provide evidence for the fabrication of a dual-action Ti surface finish, a highly desirable feature towards the development of next-generation implantable devices.

  9. SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice.

    Science.gov (United States)

    Lantier, Louise; Williams, Ashley S; Williams, Ian M; Yang, Karen K; Bracy, Deanna P; Goelzer, Mickael; James, Freyja D; Gius, David; Wasserman, David H

    2015-09-01

    Protein hyperacetylation is associated with glucose intolerance and insulin resistance, suggesting that the enzymes regulating the acetylome play a role in this pathological process. Sirtuin 3 (SIRT3), the primary mitochondrial deacetylase, has been linked to energy homeostasis. Thus, it is hypothesized that the dysregulation of the mitochondrial acetylation state, via genetic deletion of SIRT3, will amplify the deleterious effects of a high-fat diet (HFD). Hyperinsulinemic-euglycemic clamp experiments show, for the first time, that mice lacking SIRT3 exhibit increased insulin resistance due to defects in skeletal muscle glucose uptake. Permeabilized muscle fibers from HFD-fed SIRT3 knockout (KO) mice showed that tricarboxylic acid cycle substrate-based respiration is decreased while fatty acid-based respiration is increased, reflecting a fuel switch from glucose to fatty acids. Consistent with reduced muscle glucose uptake, hexokinase II (HKII) binding to the mitochondria is decreased in muscle from HFD-fed SIRT3 KO mice, suggesting decreased HKII activity. These results show that the absence of SIRT3 in HFD-fed mice causes profound impairments in insulin-stimulated muscle glucose uptake, creating an increased reliance on fatty acids. Insulin action was not impaired in the lean SIRT3 KO mice. This suggests that SIRT3 protects against dietary insulin resistance by facilitating glucose disposal and mitochondrial function. © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

  10. Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis.

    Science.gov (United States)

    Diaconu, Nicolae-Costin; Rummukainen, Jaana; Mättö, Mikko; Naukkarinen, Anita; Harvima, Rauno J; Pelkonen, Jukka; Harvima, Ilkka T

    2008-02-07

    Previous reports showed that mast cells can typically be found in the peritumoral stroma of cervix carcinomas as well as in many other cancers. Both histamine and TNF-alpha are potent preformed mast cell mediators and they can act simultaneously after release from mast cells. Thus, the effect of TNF-alpha and histamine on cervical carcinoma cell lines was studied. TNF-alpha alone induced slight growth inhibition and cell cycle arrest at G0/G1 phase in SiHa cells, but increased their migration. Histamine alone had no effect on cells. In addition, TNF-alpha and histamine in combination showed no additional effect over that by TNF-alpha alone, although SiHa cells were even pretreated with a protein synthesis inhibitor. Furthermore, TNF-alpha-sensitive ME-180 carcinoma cells were also resistant to the combination effect of TNF-alpha and histamine. In comparison, TNF-alpha or histamine alone induced growth inhibition in a non-cytolytic manner in normal keratinocytes, an effect that was further enhanced to cell cytolysis when both mediators acted in combination. Keratinocytes displayed strong TNF receptor (TNFR) I and II immunoreactivity, whereas SiHa and ME-180 cells did not. Furthermore, cervix carcinoma specimens revealed TNF-alpha immunoreactivity in peritumoral cells and carcinoma cells. However, the immunoreactivity of both TNFRs was less intense in carcinoma cells than that in epithelial cells in cervical specimens with non-specific inflammatory changes. SiHa and ME-180 cells are resistant to the cytolytic effect of TNF-alpha and histamine whereas normal keratinocytes undergo cytolysis, possibly due to the smaller amount of TNFRs in SiHa and ME-180 cells. In the cervix carcinoma, the malignant cells may resist this endogenous cytolytic action and TNF-alpha could even enhance carcinoma cell migration.

  11. Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-α and histamine whereas normal keratinocytes undergo cytolysis

    Directory of Open Access Journals (Sweden)

    Harvima Rauno J

    2008-02-01

    Full Text Available Abstract Background Previous reports showed that mast cells can typically be found in the peritumoral stroma of cervix carcinomas as well as in many other cancers. Both histamine and TNF-α are potent preformed mast cell mediators and they can act simultaneously after release from mast cells. Thus, the effect of TNF-α and histamine on cervical carcinoma cell lines was studied. Methods and results TNF-α alone induced slight growth inhibition and cell cycle arrest at G0/G1 phase in SiHa cells, but increased their migration. Histamine alone had no effect on cells. In addition, TNF-α and histamine in combination showed no additional effect over that by TNF-α alone, although SiHa cells were even pretreated with a protein synthesis inhibitor. Furthermore, TNF-α-sensitive ME-180 carcinoma cells were also resistant to the combination effect of TNF-α and histamine. In comparison, TNF-α or histamine alone induced growth inhibition in a non-cytolytic manner in normal keratinocytes, an effect that was further enhanced to cell cytolysis when both mediators acted in combination. Keratinocytes displayed strong TNF receptor (TNFR I and II immunoreactivity, whereas SiHa and ME-180 cells did not. Furthermore, cervix carcinoma specimens revealed TNF-α immunoreactivity in peritumoral cells and carcinoma cells. However, the immunoreactivity of both TNFRs was less intense in carcinoma cells than that in epithelial cells in cervical specimens with non-specific inflammatory changes. Conclusion SiHa and ME-180 cells are resistant to the cytolytic effect of TNF-α and histamine whereas normal keratinocytes undergo cytolysis, possibly due to the smaller amount of TNFRs in SiHa and ME-180 cells. In the cervix carcinoma, the malignant cells may resist this endogenous cytolytic action and TNF-α could even enhance carcinoma cell migration.

  12. 76 FR 12711 - Smart Grid Advisory Committee

    Science.gov (United States)

    2011-03-08

    ... National Institute of Standards and Technology Smart Grid Advisory Committee AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Smart Grid... will be posted on the Smart Grid Web site at http://www.nist.gov/smartgrid . DATES: The SGAC will hold...

  13. 76 FR 46279 - Smart Grid Advisory Committee

    Science.gov (United States)

    2011-08-02

    ... National Institute of Standards and Technology Smart Grid Advisory Committee AGENCY: Department of Commerce, National Institute of Standards and Technology ACTION: Notice of open meeting. SUMMARY: The Smart Grid... should be sent to Office of the National Coordinator for Smart Grid Interoperability, National Institute...

  14. 77 FR 38768 - Smart Grid Advisory Committee

    Science.gov (United States)

    2012-06-29

    ... National Institute of Standards and Technology Smart Grid Advisory Committee AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Smart Grid... the Smart Grid Interoperability Panel transition plan, review the status of the research subcommittee...

  15. 78 FR 41384 - Agricultural Advisory Committee Meeting

    Science.gov (United States)

    2013-07-10

    ... COMMODITY FUTURES TRADING COMMISSION Agricultural Advisory Committee Meeting AGENCY: Commodity Futures Trading Commission. ACTION: Notice of Meeting. SUMMARY: The Commodity Futures Trading Commission's... Notice, will connect to a live, listen-only audio feed. The international toll and toll-free numbers will...

  16. 75 FR 67351 - Nuclear Energy Advisory Committee

    Science.gov (United States)

    2010-11-02

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear... [email protected]nuclear.energy.gov . SUPPLEMENTARY INFORMATION: Background: The Nuclear Energy Advisory...

  17. 78 FR 29125 - Nuclear Energy Advisory Committee

    Science.gov (United States)

    2013-05-17

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear... Independence Avenue SW., Washington DC 20585; telephone (301) 903-9096; email [email protected]nuclear.energy.gov...

  18. 75 FR 75671 - Regional Advisory Committees

    Science.gov (United States)

    2010-12-06

    ... Education. ACTION: Request for nominations to serve on the Regional Advisory Committees. SUMMARY: The... institutions of higher education, including those that represent university-based research on education and on subjects other than education; parents; practicing educators, including classroom teachers, principals...

  19. Quantitative analysis of vasodilatory action of quercetin on intramural coronary resistance arteries of the rat in vitro.

    Directory of Open Access Journals (Sweden)

    Anna Monori-Kiss

    Full Text Available BACKGROUND: Dietary quercetin improves cardiovascular health, relaxes some vascular smooth muscle and has been demonstrated to serve as a substrate for the cyclooxygenase enzyme. AIMS: 1. To test quantitatively a potential direct vasodilatory effect on intramural coronary resistance artery segments, in different concentrations. 2. To scale vasorelaxation at different intraluminal pressure loads on such vessels of different size. 3. To test the potential role of prostanoids in vasodilatation induced by quercetin. METHODS: Coronary arterioles (70-240 µm were prepared from 24 rats and pressurized in PSS, using a pressure microangiometer. RESULTS: The spontaneous tone that developed at 50 mmHg was relaxed by quercetin in the 10(-9 moles/lit concentration (p<0.05, while 10(-5 moles/lit caused full relaxation. Significant relaxation was observed at all pressure levels (10-100 mmHg at 10(-7 moles/lit concentration of quercetin. The cyclooxygenase blocker indomethacin (10(-5 moles/lit induced no relaxation but contraction when physiological concentrations of quercetin were present in the tissue bath (p<0.02 with Anova, this contraction being more prominent in smaller vessels and in the higher pressure range (p<0.05, Pearson correlation. A further 2-8% contraction could be elicited by the NO blocker L-NAME (10(-4 moles/lit. CONCLUSION: These results demonstrate that circulating levels of quercetin (10(-7 moles/lit exhibit a substantial coronary vasodilatory effect. The extent of it is commeasurable with that of several other physiological mechanisms of coronary blood flow control. At least part of this relaxation is the result of an altered balance toward the production of endogenous vasodilatory prostanoids in the coronary arteriole wall.

  20. 75 FR 67696 - Meeting of the Defense Department Advisory Committee on Women in the Services (DACOWITS)

    Science.gov (United States)

    2010-11-03

    ... of the Secretary Meeting of the Defense Department Advisory Committee on Women in the Services (DACOWITS) AGENCY: Department of Defense. ACTION: Notice. SUMMARY: Pursuant to Section 10(a), Public Law 92... Committee on Women in the Services (DACOWITS). The purpose of the meeting is for the Committee to receive...

  1. 75 FR 4140 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2010-01-26

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS) Treasury. ACTION... Tax Credit Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public... Advocacy Panel Earned Income Tax Credit Project Committee will be held Wednesday, February 24, 2010, at 1 p...

  2. 76 FR 6120 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

    Science.gov (United States)

    2011-02-03

    ... [Release No. 34-63798; File No. 265-26] Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues...''). ACTION: Notice of Meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. SUMMARY: The Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues will hold a public meeting on...

  3. 75 FR 44781 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

    Science.gov (United States)

    2010-07-29

    ... COMMISSION SECURITIES AND EXCHANGE COMMISSION Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues...''). ACTION: Notice of Meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. SUMMARY: The Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues will hold a public meeting on...

  4. 75 FR 66362 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

    Science.gov (United States)

    2010-10-28

    ... COMMISSION SECURITIES AND EXCHANGE COMMISSION Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues...''). ACTION: Notice of meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. SUMMARY: The Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues will hold a public meeting on...

  5. 76 FR 38742 - Seventh Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Science.gov (United States)

    2011-07-01

    ... Committee 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held July 15, 2011, from...

  6. 75 FR 71790 - Second Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Science.gov (United States)

    2010-11-24

    ... Committee 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held December 9, 2010...

  7. 76 FR 3931 - Fourth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Science.gov (United States)

    2011-01-21

    ... Committee 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 Meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held February 8, 2011...

  8. Guide to School Health and Safety Committees: How To Promote Child and Adult Environmental Health Protection.

    Science.gov (United States)

    Healthy Schools Network, Inc., Albany, NY.

    This guide discusses the importance of having school health and safety committees, describes New York law creating these committees, explores their responsibilities and recommended actions, and examines what committees can do to efficiently meet their goals. The guide details school walk-throughs as the best way to learn about a school, including…

  9. 76 FR 71611 - Notice of Establishment of the Fort Winfield Scott Advisory Committee

    Science.gov (United States)

    2011-11-18

    ... PRESIDIO TRUST Notice of Establishment of the Fort Winfield Scott Advisory Committee AGENCY: The Presidio Trust. ACTION: Notice of establishment of the Fort Winfield Scott Advisory Committee. SUMMARY... the Presidio Trust announces the intent to establish the Fort Winfield Scott Advisory Committee...

  10. 76 FR 44045 - Establishment of the SANE/SART AI/AN Initiative Committee

    Science.gov (United States)

    2011-07-22

    ... SANE/SART AI/AN Initiative Committee AGENCY: Office for Victims of Crime, Justice. ACTION: Notice of... Nurse Examiner (SANE) Sexual Assault Response Team (SART) American Indian/Alaskan Native (AI/AN) Initiative (``SANE/SART AI/AN Initiative Committee'' or ``Committee'') is being established in accordance...

  11. 76 FR 46312 - Advisory Committee on Commercial Operations of Customs and Border Protection (COAC)

    Science.gov (United States)

    2011-08-02

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. USCBP-2011-0024] Advisory Committee on Commercial... Homeland Security (DHS). ACTION: Committee management; notice of Federal Advisory Committee meeting...-of-business on August 12, 2011. ADDRESSES: The meeting will be held at the Westin Long Beach Hotel...

  12. 77 FR 12077 - Meeting of the Judicial Conference Advisory Committee on Rules of Bankruptcy Procedure

    Science.gov (United States)

    2012-02-28

    ... UNITED STATES Meeting of the Judicial Conference Advisory Committee on Rules of Bankruptcy Procedure AGENCY: Judicial Conference of the United States Advisory Committee on Rules of Bankruptcy Procedure. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Rules of Bankruptcy Procedure will...

  13. 76 FR 27089 - Meeting of the Judicial Conference Advisory Committee on Rules of Bankruptcy Procedure

    Science.gov (United States)

    2011-05-10

    ... UNITED STATES Meeting of the Judicial Conference Advisory Committee on Rules of Bankruptcy Procedure AGENCY: Judicial Conference of the United States Advisory Committee on Rules of Bankruptcy Procedure. ACTION: Notice of Open Meeting. SUMMARY: The Advisory Committee on Rules of Bankruptcy Procedure will...

  14. 75 FR 32816 - Meeting of the Judicial Conference Advisory Committee on Rules of Bankruptcy Procedure

    Science.gov (United States)

    2010-06-09

    ... UNITED STATES Meeting of the Judicial Conference Advisory Committee on Rules of Bankruptcy Procedure AGENCY: Judicial Conference of the United States Advisory Committee on Rules of Bankruptcy Procedure. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Rules of Bankruptcy Procedure will...

  15. Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells.

    Science.gov (United States)

    Gupta, Akash; Mehta, Rajeshwari; Alimirah, Fatouma; Peng, Xinjian; Murillo, Genoveva; Wiehle, Ronald; Mehta, Rajendra G

    2013-01-01

    Aromatase inhibitors (AI) are considered as a first line therapy for ER+PR+ breast cancers. However, many patients acquire resistance to AI. In this study, we determined the response of antiprogestin CDB-4124 (Proellex) on the aromatase overexpressing and Letrozole resistant cell lines and also studies its mechanism of action in inhibition of breast cancer cell proliferation. For these studies we generated aromatase overexpressing T47D (T47Darom) and respective control (T47Dcon) breast cancer cell lines by stable transfection with plasmid containing CYP19A1 gene, or empty vector respectively. Letrozole resistant cell line (T47DaromLR) was generated by incubating T47Darom for 75 weeks in the presence of 10 μM Letrozole. Cell proliferation was determined by MTT or crystal violet assays. Gene expressions were quantified by QRT-PCR whereas proteins were identified by western blot analyses, flow cytometry and immunofluorescence staining. Aromatase activity was determined by estradiol ELISA. The effects of Proellex on the anchorage independent growth were measured by soft agar colony formation. Statistical differences between the various groups were determined by Student's 't' test or ANOVA followed by Bonferroni's post hoc test. Results showed that T47Darom and T47DaromLR cell lines had significantly higher aromatase expression (mRNA; 80-90 fold and protein) and as a result exhibited increased aromatization of testosterone to estradiol as compared to T47Dcon. Both these cell lines showed enhanced growth in the presence of Testosterone (50-60%). In T47DaromLR cells increased PR-B and EGFR expression as compared to T47Dcon cells was observed. Proellex and other known aromatase inhibitors (Letrozole, Anastrozole, and Exemestane) inhibited testosterone induced cell proliferation and anchorage independent growth of T47Darom cells. Cell growth inhibition was significantly greater when cells were treated with Proellex alone or in combination with other AIs as compared to AIs

  16. 75 FR 60430 - Federal Advisory Committee; Threat Reduction Advisory Committee

    Science.gov (United States)

    2010-09-30

    ... of the Secretary Federal Advisory Committee; Threat Reduction Advisory Committee AGENCY: Office of... meeting. SUMMARY: Under the provisions of the Federal Advisory Committee Act of 1972 (5 U.S.C., Appendix... announces a meeting of the Threat Reduction Advisory Committee (hereafter referred to as ``the Committee...

  17. Fitting membrane resistance along with action potential shape in cardiac myocytes improves convergence: application of a multi-objective parallel genetic algorithm.

    Directory of Open Access Journals (Sweden)

    Jaspreet Kaur

    Full Text Available Fitting parameter sets of non-linear equations in cardiac single cell ionic models to reproduce experimental behavior is a time consuming process. The standard procedure is to adjust maximum channel conductances in ionic models to reproduce action potentials (APs recorded in isolated cells. However, vastly different sets of parameters can produce similar APs. Furthermore, even with an excellent AP match in case of single cell, tissue behaviour may be very different. We hypothesize that this uncertainty can be reduced by additionally fitting membrane resistance (Rm. To investigate the importance of Rm, we developed a genetic algorithm approach which incorporated Rm data calculated at a few points in the cycle, in addition to AP morphology. Performance was compared to a genetic algorithm using only AP morphology data. The optimal parameter sets and goodness of fit as computed by the different methods were compared. First, we fit an ionic model to itself, starting from a random parameter set. Next, we fit the AP of one ionic model to that of another. Finally, we fit an ionic model to experimentally recorded rabbit action potentials. Adding the extra objective (Rm, at a few voltages to the AP fit, lead to much better convergence. Typically, a smaller MSE (mean square error, defined as the average of the squared error between the target AP and AP that is to be fitted was achieved in one fifth of the number of generations compared to using only AP data. Importantly, the variability in fit parameters was also greatly reduced, with many parameters showing an order of magnitude decrease in variability. Adding Rm to the objective function improves the robustness of fitting, better preserving tissue level behavior, and should be incorporated.

  18. Committee Reports, May 2008

    Science.gov (United States)

    2008-08-01

    The Division's Executive Committee conducted several items of business at the New Orleans meeting. Elsewhere in this issue [see p 1032] is a listing of the candidates for Division offices for Fall 2008 election, approved by the Committee and later affirmed at the Division business meeting. Among items of specific interest to Division members is a plan to have the Journal of Chemical Education send an announcement to members when each issues goes online, and the Committee approved this use of the Division email list. It also approved plans presented by Amina El-Ashmawy and the BCCE committee to proceed with a bid from Pennsylvania State University for the 2012 BCCE.

  19. 77 FR 27832 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-05-11

    ... organizations --Relations with non-governmental organizations --World Maritime Day --International Maritime... DEPARTMENT OF STATE [Public Notice: 7879] Shipping Coordinating Committee; Notice of Committee...-second Session of the International Maritime Organization (IMO) Technical Co-operation Committee (TCC 62...

  20. 78 FR 32698 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-05-31

    ... intergovernmental organizations --Relations with non-governmental organizations --World Maritime Day --International... DEPARTMENT OF STATE [Public Notice 8340] Shipping Coordinating Committee; Notice of Committee... Session of the International Maritime Organization (IMO) Technical Co-operation Committee (TCC 63) to be...

  1. Nutrigenomic point of view on effects and mechanisms of action of ruminant trans fatty acids on insulin resistance and type 2 diabetes.

    Science.gov (United States)

    Tremblay, Bénédicte L; Rudkowska, Iwona

    2017-03-01

    Evidence from observational studies suggests beneficial effects of ruminant trans fatty acids (rTFA) on insulin resistance (IR) and type 2 diabetes (T2D). However, beneficial effects of rTFA are not always observed in cell, animal, and human studies. This narrative review presents potential mechanisms of action of rTFA using nutrigenomics and microRNA results in an integrative model. In addition, the review presents factors, including measures of IR and T2D, dose and duration of studies, as well as health status, ethnicity, and genotypes of subjects, that may help explain the heterogeneity in response to rTFA supplementation. Future studies should consider these factors, as well as research in nutritional genomics, to better understand the effects of rTFA on IR and T2D. © The Author(s) 2017. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  2. Metodologia de avaliação qualitativa das ações dos Comitês de Bacias com ênfase na gestão integrada: o Comitê do Alto Tietê em São Paulo Methodology of qualitative evaluation of the actions of the River Basins Committees giving emphasis to the integrated management: the High Tiete River Basin Committee in São Paulo

    Directory of Open Access Journals (Sweden)

    Angélica A. Tanus Benatti Alvim

    2007-09-01

    Full Text Available Este artigo apresenta uma metodologia de avaliação qualitativa das ações do comitê de bacia hidrográfica com ênfase na teoria de gestão integrada. Apresenta-se a teoria de gestão integrada de bacia hidrográfica e sua relação com a Política Estadual de Recursos Hídricos do Estado de São Paulo. A metodologia é construída a partir de um conjunto de indicadores qualitativos implícitos ao conceito "articulação" que mensuram de forma particularizada cada aspecto desse fenômeno. Aplica-se a metodologia nas ações do Comitê do Alto Tietê, instância de gestão das águas da Região Metropolitana de São Paulo. Os resultados permitem verificar não só o nível de articulação de suas ações, mas também em que aspectos esse fórum tem contribuído à gestão integrada do território metropolitano.This paper presents a method of qualitative evaluation of the actions of the river basin committee, giving emphasis to the theory of integrated management. It presents the theory of integrated management of river basins and its relation with the Politics of the State of São Paulo on water resources. The methodology is arranged from one ensemble of qualitative indicators implicit in the concept of articulation that measure in a particularized way each aspect of the phenomenon. The methodology is implemented by the study of the High Tietê River Committee, entity that is responsible for the management of water resources in the São Paulo Metropolitan Region. The results allow verifying not only the level of articulation of its actions, but also in what aspects this forum has contributed to the integrated management of the metropolitan region.

  3. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of sixth biannual meeting (September 2014).

    Science.gov (United States)

    2015-03-10

    The Malaria Policy Advisory Committee to the World Health Organization held its sixth meeting in Geneva, Switzerland from 10 to 12 September 2014. This article provides a summary of the discussions, conclusions and recommendations from that meeting.Meeting sessions covered the following: an update on drug resistance and containment including an assessment on the feasibility of elimination of Plasmodium falciparum malaria in the Greater Mekong Subregion; guidance on the control of residual malaria transmission by behaviourally resistant vectors; progress on the implementation of the Global Plan for Insecticide Resistance Management; updates on the Global Technical Strategy, Global Malaria Action Plan and the Plasmodium vivax technical brief; gaps in current World Health Organization Global Malaria Programme guidance for acceleration to elimination; surveillance, monitoring and evaluation; the updated World Health Organization Guidelines for the Prevention and Treatment of Malaria; Round 5 product testing for rapid diagnostic tests; and Intermittent Preventive Treatment for infants.Policy statements, position statements, and guidelines that arise from the Malaria Policy Advisory Committee meeting conclusions and recommendations will be formally issued and disseminated to World Health Organization Member States by the World Health Organization Global Malaria Programme.

  4. Ethics committees in Croatia

    NARCIS (Netherlands)

    Borovecki, Ana

    2007-01-01

    In this thesis the work of ethics committees in Croatia is being investigated for the first time. The 1997 Law on Health Protection introduced legal standards for the establishment of the so-called 'mixed' type of ethics committees in healthcare institutions. Our study aims to examine whether this

  5. 78 FR 77663 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Science.gov (United States)

    2013-12-24

    ..., Technology and Logistics), DoD. ACTION: Federal Advisory Committee meeting notice. SUMMARY: The Department of... what a strategic I&W capability should consist of and what role or gap the GCAS should fill. The... the public. The Under Secretary of Defense for Acquisition, Technology and Logistics, in consultation...

  6. 78 FR 69612 - Negotiated Rulemaking Committee, Negotiator Nominations and Schedule of Committee Meetings-Title...

    Science.gov (United States)

    2013-11-20

    .... ACTION: Notice of intention to establish. SUMMARY: We announce our intention to establish a negotiated... Policy and Campus Crime Statistics Act (Clery Act); and the definition of ``adverse credit'' for... announced our intention to establish a negotiated rulemaking committee to prepare proposed regulations to...

  7. 78 FR 29334 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Science.gov (United States)

    2013-05-20

    ..., Technology and Logistics), Department of Defense. ACTION: Federal Advisory Committee Meeting Notice. SUMMARY... Threat Reduction program, and C-WMD Strategic Indicators and Warnings. Meeting Accessibility: Pursuant to... Logistics, in consultation with the DoD FACA Attorney, has determined in writing that the public interest...

  8. 78 FR 60863 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Science.gov (United States)

    2013-10-02

    ..., Technology and Logistics), DoD. ACTION: Federal Advisory Committee meeting notice. SUMMARY: The Department of..., and C-WMD Strategic Indicators and Warnings. Meeting Accessibility: Pursuant to 5 U.S.C. 552b, and 41... public. The Under Secretary of Defense for Acquisition, Technology and Logistics, in consultation with...

  9. 76 FR 5160 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Science.gov (United States)

    2011-01-28

    ... Age AGENCY: Federal Communications Commission. ACTION: Notice of intent to renew charter. SUMMARY: In... Communications Commission (FCC) has renewed the charter of the Advisory Committee on Diversity for Communications... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS...

  10. Pesticide Program Dialogue Committee (PPDC)

    Science.gov (United States)

    The Pesticide Program Dialogue Committee, a permanent, broadly representative advisory committee, meets with EPA on a regular basis to discuss pesticide regulatory, policy, and program implementation issues.

  11. The Audit Committee. Effective Committees. Board Basics.

    Science.gov (United States)

    Ostrom, John S.

    1996-01-01

    In many colleges and universities the responsibility of the governing board's audit committee is to arrange and oversee regular audits of financial activities, comply with donor restrictions on gifts, adhere to laws and regulations, and conform to established board policies. Membership of three to five is usually sufficient, and while the…

  12. Co-ordinate action of bacterial adhesins and human carcinoembryonic antigen receptors in enhanced cellular invasion by capsulate serum resistant Neisseria meningitidis.

    Science.gov (United States)

    Rowe, Helen A; Griffiths, Natalie J; Hill, Darryl J; Virji, Mumtaz

    2007-01-01

    Neisseria meningitidis (Nm) is a human specific opportunistic pathogen that occasionally penetrates mucosal barriers via the action of adhesins and invasins and evades host immune mechanisms during further dissemination via capsule expression. From in vitro studies, the primary adhesion of capsulate bacteria is believed to be mediated by polymeric pili, followed by invasion via outer membrane adhesins such as Opa proteins. As the latter requires the surface capsule to be down-modulated, invading bacteria would be serum sensitive and thus avirulent. However, there is recent evidence that capsulate bacteria may interact via Opa proteins when host cells express high levels of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), their target receptors. Such a situation may arise following increased circulation of inflammatory cytokines that upregulate certain adhesion molecules on host cells. In this study, using a tetracycline controlled expression system, we have developed cell lines with inducible CEACAM expression to mimic post-inflammation state of target tissues and analysed the interplay between the three surface components capsule, pili and Opa proteins in cellular interactions. With two distinct cell lines, not only the level but also the rate of adhesion of capsulate Opa-expressing Nm increased concurrently with CEACAM density. Moreover, when threshold levels of receptor were reached, cellular invasion ensued in an Opa-dependent manner. In studies with cell lines intrinsically expressing pilus receptors, notable synergism in cellular interactions between pili and Opa of several meningococcal strains was observed and was independent of capsule type. A number of internalized bacteria were shown to express capsule and when directly isolated from host cells, these bacteria were as serum resistant as the inoculated phenotype. Furthermore, we observed that agents that block Opa-CEACAM binding substantially reduced cellular invasion, while maintaining

  13. The antidiabetic action of camel milk in experimental type 2 diabetes mellitus: an overview on the changes in incretin hormones, insulin resistance, and inflammatory cytokines.

    Science.gov (United States)

    Korish, A A

    2014-06-01

    Folk medicine stories accredited the aptitude of camel milk (CMK) as a hypoglycemic agent and recent studies have confirmed this in the diabetic patients and experimental animals. However, the mechanism(s) by which CMK influences glucose homeostasis is yet unclear. The current study investigated the changes in the glucose homeostatic parameters, the incretin hormones, and the inflammatory cytokines in the CMK-treated diabetic animals. A model of type 2 diabetes mellitus was induced in rats by intraperitoneal injection of streptozotocin 40 mg/kg/day for 4 repeated doses. Camel milk treatment was administered for 8 weeks. The changes in glucagon like peptide-1 (GLP-1), glucose dependent insulinotropic peptide (GIP), glucose tolerance, fasting and glucose-stimulated insulin secretion, insulin resistance (IR), TNF-α, TGF-β1, lipid profile, atherogenic index (AI), and body weight were investigated. The untreated diabetic animals showed hyperglycemia, increased HOMA-IR, hyperlipidemia, elevated AI, high serum incretins [GLP-1 and GIP], TNF-α, and TGF-β1 levels and weight loss as compared with the control group. Camel milk treatment to the diabetic animals resulted in significant lowered fasting glucose level, hypolipidemia, decreased HOMA-IR, recovery of insulin secretion, weight gain, and no mortality during the study. Additionally, CMK inhibits the diabetes-induced elevation in incretin hormones, TNF-α and TGF-β1 levels. The increase in glucose-stimulated insulin secretion, decreased HOMA-IR, modulation of the secretion and/or the action of incretins, and the anti-inflammatory effect are anticipated mechanisms to the antidiabetic effect of CMK and suggest it as a valuable adjuvant antidiabetic therapy. © Georg Thieme Verlag KG Stuttgart · New York.

  14. 75 FR 43156 - Federal Advisory Committee; Missile Defense Advisory Committee

    Science.gov (United States)

    2010-07-23

    ... Office of the Secretary Federal Advisory Committee; Missile Defense Advisory Committee AGENCY: Missile... Advisory Committee Act of 1972 (5 U.S.C., Appendix, as amended) and the Government in the Sunshine Act of... Missile Defense Advisory Committee will meet on August 4 and 5, 2010, in Washington, DC. DATES: The...

  15. 75 FR 9416 - Advisory Committee Information Hotline

    Science.gov (United States)

    2010-03-02

    ... BIOLOGICS EVALUATION AND RESEARCH Allergenic Products Advisory Committee 3014512388 Blood Products Advisory... Committee 3014512391 CENTER FOR DRUG EVALUATION AND RESEARCH Anesthetic and Life Support Drugs Advisory Committee 3014512529 Anti-Infective Drugs Advisory Committee 3014512530 Antiviral Drugs Advisory Committee...

  16. Standing Concertation Committee

    CERN Multimedia

    HR Department

    2010-01-01

    Main issues examined at the meeting of 2 October 2009 The October 2009 meeting of the Standing Concertation Committee was entirely devoted to preparation of TREF’s meeting on 21-22 October. The Committee took note of, discussed and agreed on clarifications needed to some of the documents and presentations that the Management intended to submit and/or present to TREF on the following subjects: Equal opportunities The Committee took note of a preliminary report on equal opportunities at CERN drawn up by D. Chromek-Burckhart, the Equal Opportunities Officer, and T. Smith, Chairman of the Equal Opportunities Advisory Panel, containing in particular a proposal for a new process for resolving harassment conflicts. Technical analysis of the CERN Health Insurance Scheme - Actuary’s Report The Committee took note of a presentation by P. Charpentier, Chairman of the CERN Health Insurance Supervisory Board (CHIS Board), on the 2009 actuarial report on the CERN Health Insurance Scheme (CHIS). Th...

  17. Standing Concertation Committee

    CERN Multimedia

    HR Department

    2008-01-01

    ORDINARY MEETING ON 27 FEBRUARY 2008 The main items discussed at the meetings of the Standing Concertation Committee on 27 February 2008 included: Short-term Saved Leave Scheme The Committee noted that, by the end of February 2008, some 600 staff had enrolled in the short-term saved leave scheme: approx. 58% had signed up for 1 slice, 14% for two slices, 5% for three slices and 23% for four slices. Administrative Circular No. 4 (Rev. 4) - Unemployment Insurance Scheme The Committee agreed to recommend the Director-General to approve Administrative Circular No. 4 (Rev. 4) - Unemployment Insurance Scheme. Administrative Circular No. 30 (Rev. 2) - Financial benefits upon taking up appointment and termination of contract The Committee agreed to recommend the Director-General to approve Administrative Circular No. 30 (Rev. 2) - Financial Benefits upon taking up appointment and termination of contract. Progressive Retirement Programme The Progressive Retirement Programme (PR...

  18. Lawrence Berkeley Laboratory Ergonomics Committee FY 94 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-01

    This report presents the Committee`s accomplishments for fiscal year 1994. Ergonomic issues are getting increased attention nationwide. This is a result of ergonomic hazards impacting the safety and health of employees, and companies ``bottom line`` via an increase in medical and workers` compensation costs. The Committee reviews injury and illness data, advises management of ergonomic trends at LBL, initiates corrective action to mitigate ergonomic hazards, and sponsors ergonomic awareness activities. Documented evidence supports the claim that implementing cost-effective ergonomic solutions are a good investment.

  19. On the contribution of reclaimed wastewater irrigation to the potential exposure of humans to antibiotics, antibiotic resistant bacteria and antibiotic resistance genes - NEREUS COST Action ES1403 position paper

    DEFF Research Database (Denmark)

    Piña, Benjamin; Bayona, Josep M.; Christou, Anastasis

    2018-01-01

    Antibiotic resistance (AR) is becoming a worldwide threat due to the increasing occurrence of antibiotic-resistant pathogenic bacterial strains. There is a general consensus about the potential implications of the use of antibiotics in livestock on the onset of antibiotic resistant bacteria (ARB)...

  20. Resistência de alguns vírus à ação oligodinâmica da prata Resistence of some viruses to the silver oligodynamic action

    Directory of Open Access Journals (Sweden)

    J. Guilherme Lacorte

    1959-10-01

    Full Text Available Tentamos verificar, em algumas experiências, a ação oligodinâmica da prata sôbre os vírus da coriomeningite linfocitária benigna, amostra WE, da poliomielite, amostra MEF1, e da vacina, amostra do Instituto Oswaldo Cruz, como o haviamos feito com o vírus da gripe, amostras PR8 e DL/Rio. Nas provas usamos recipientes de barro, recobertos de fina camada de prata na parede interna, ou aquêles em que a prata, sob a forma de pó se misturava ao próprio barro. Esses recipientes são denominados, no comércio, moringas esterilizantes. Colocou-se, no seu interior, a emulsão a 10% do tecido cerebral contendo o vírus da coriomeningite linfocitária ou da poliomielite, verificando-se o seu poder patogênico para camundongos, em intervalos regulares, pela injeção intracerebral de 0,03 ml do material. Os resultados, que podem ser vistos nos Quadros 1 e 2, indicam que aquêles virus resistem à ação oligodinâmica da prata. No caso do vírus da vacina, a diluição foi colocada, da mesma maneira, nos referidos recipientes. O vírus apresentou, também, completa resistência, conforme se vê nas figuras de 1, 2 e 3. Experiências testemunhas feitas com Micrococcus pyogenes e Escherichia coli, cujas suspensões foram igualmente colocadas nas moringas esterilizantes, revelaram que as bactérias não sobreviviam além de 20 horas. Frizamos, na publicação sôbre vírus da gripe, que o referido fenômeno é importante porque sabemos que o efieto oligodinâmico se observa sôbre microorganismos como bactérias, protozoários e outros seres vivos, alterando as suas propriedades ou matando-os sendo, portanto, interessante sob o ponto de vista biológico. O fenômeno pode ainda ser aplicado para o isolamento de vírus, quando em contaminação com bactérias.We have tried to verify, in some experiments, the silver oligodynamic action upon the lymphocytic choriomeningitis virus, WE strain the poliomyelitis virus, MEF1 strain, and the vaccinia virus

  1. Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action

    DEFF Research Database (Denmark)

    Xiong, L; Kloss, P; Douthwaite, S

    2000-01-01

    , we selected Escherichia coli oxazolidinone-resistant mutants, which contained a randomly mutagenized plasmid-borne rRNA operon. The same mutation, G2032 to A, was identified in the 23S rRNA genes of several independent resistant isolates. Engineering of this mutation by site-directed mutagenesis...

  2. Standing Concertation Committee

    CERN Multimedia

    HR Department

    2009-01-01

    Main points examined at the meeting of 24 June 2009 Results of the 2009 MARS exercise The Committee took note of the results of the 2009 MARS exercise presented by the Head of the HR Department, expressing satisfaction for the early availability of the statistics and for the fact that the analysis of the results covered the last three years. Status report on the work on the five-yearly review The Committee took note of a presentation by P. Gildemyn on the data collection procedure for the 2010 five-yearly review (staff, fellows, associate members of the personnel, CHIS) and of the proposed work schedule. Implications for employment conditions of the discussions at the Finance Committee and Council on 17 and 18 June 2009 The Chairman briefly reported on the discussions at the meetings of the Finance Committee and Council in June 2009, on the 2010-2014 medium-term plan and the 2010 preliminary draft budget, as well as on the modified strategy and goals for 2009. The Committee ...

  3. American Samoa Energy Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    Haase, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Esterly, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States); Herdrich, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bodell, Tim [National Renewable Energy Lab. (NREL), Golden, CO (United States); Visser, Charles [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-08-01

    Describes the five near-term strategies selected by the American Samoa Renewable Energy Committee (ASREC) during action planning workshops conducted in May 2013, and outlines the actions being taken to implement those strategies. Each option is tied to a priority identified in the earlier draft American Samoa Strategic Energy Plan as being an essential component of reducing American Samoa'spetroleum energy consumption. The actions described for each strategy provide a roadmap to facilitate the implementation of each strategy. This document is intended to evolve along with the advancement of the projects, and will be updated to reflect progress.

  4. 75 FR 27614 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-05-17

    ... Environment Protection Committee. --Consideration of the report of the Maritime Safety Committee... Session of the International Maritime Organization (IMO) Council to be held at the IMO headquarters in... HNS Convention. --World Maritime University: --IMO International Maritime Law Institute: --Protection...

  5. 77 FR 57637 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-09-18

    ... DEPARTMENT OF STATE [Public Notice 8031] Shipping Coordinating Committee; Notice of Committee... relating to the 1977 Torremolinos Convention on the Safety of Fishing Vessels --IMO International Maritime... administrative requirements in mandatory IMO instruments --External relations: --Relations with the United...

  6. 77 FR 76164 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-12-26

    ... atmospheric pollution --Development of international measures for minimizing the transfer of invasive aquatic... pollution hazards of chemicals and preparation of consequential amendments --Additional guidelines for... DEPARTMENT OF STATE [Public Notice 8133] Shipping Coordinating Committee; Notice of Committee...

  7. Committees and supporting organizations

    Science.gov (United States)

    2011-09-01

    Advisory Committee:Organizing Committee: Marcello Baldo (Catania)Takaharu Otsuka (Tokyo), co-chair George Bertsch (Seattle)Michael Urban (Orsay), co-chair Jean-Paul Blaizot (Saclay)Taiichi Yamada (Yokohama) Michel Girod (Bruyères-le-Châtel)Nguyen van Giai (Orsay) Hisashi Horiuchi (Osaka)Shinichiro Fujii (Tokyo) Umberto Lombardo (Catania)Jérôme Margueron (Orsay) Gerd Röpke (Rostock)Kouichi Hagino (Sendai) Hiroyuki Sagawa (Aizu)Yoshiko Kanada-En'yo (Kyoto) Piet Van Isacker (Caen) Enrico Vigezzi (Milano) IPN logo    EFES logo    CNRS logo    ihp logo

  8. Glucagon-Like Peptide 1 Recruits Muscle Microvasculature and Improves Insulin?s Metabolic Action in the Presence of Insulin Resistance

    OpenAIRE

    Chai, Weidong; Zhang, Xingxing; Barrett, Eugene J.; Liu, Zhenqi

    2014-01-01

    Glucagon-like peptide 1 (GLP-1) acutely recruits muscle microvasculature, increases muscle delivery of insulin, and enhances muscle use of glucose, independent of its effect on insulin secretion. To examine whether GLP-1 modulates muscle microvascular and metabolic insulin responses in the setting of insulin resistance, we assessed muscle microvascular blood volume (MBV), flow velocity, and blood flow in control insulin-sensitive rats and rats made insulin-resistant acutely (systemic lipid in...

  9. Federal Advisory Committees at EPA

    Science.gov (United States)

    FACA committees are created to obtain advice on a wide range of environmental issues. Every committee meeting, no matter what the subject matter or where it is held, is dedicated to open government and citizen participation.

  10. SENIOR STAFF ADVANCEMENT COMMITTEE (SSAC)

    CERN Multimedia

    2000-01-01

    Composition and mandateThe Senior Staff Advancement Committee is composed of members nominated ad persona by the Director-General.The Committee examines proposals from Divisions concerning promotions to grade 13 in Career Path IX, changes of career path to Career Path IX and advancements to the exceptional grade in Career path VIII.The Director-General may consult the Committee on any matter related to senior staff careers.The Committee makes its recommendations to the Director-General.

  11. Plasma Science Committee (PLSC)

    International Nuclear Information System (INIS)

    1990-01-01

    The Plasma Science Committee (PLSC) is a standing committee under the auspices of the Board on Physics and Astronomy, Commission on Physical Sciences, Mathematics, and Applications of the National Academy of Sciences--National Research Council. Plasma sciences represent a broad and diverse field. The PLSC has accepted the responsibility of monitoring the continuing development and assessing the general health of the field as whole. Although select advisory bodies have been created to address specific issues that affect plasma science, such as the Fusion Policy Advisory Committee (FPAC), the PLSC provides a focus for the plasma science community that is unique and essential. The membership of the PLSC is drawn from research laboratories in universities, industry, and government. Areas of expertise on the committee include accelerators and beams, space physics, astrophysics, computational physics and applied mathematics, fusion plasmas, fundamental experiments and theory, radiation sources, low temperature plasmas, and plasma-surface interactions. The PLSC is well prepared to respond to requests for studies on specific issues. This report discusses ion of the PLSC work

  12. Rebuilding a Research Ethics Committee

    Science.gov (United States)

    Biggs, John S. G.; Marchesi, August

    2013-01-01

    The principal ethics committee in Australia's Capital, Canberra, underwent a major revision in the last three years based on changes debated in the literature. Committee or Board structure varies widely; regulations determining minimum size and membership differ between countries. Issues such as the effectiveness of committee management,…

  13. The Audit Committee. Board Basics

    Science.gov (United States)

    Ostrom, John S.

    2004-01-01

    The Effective Committees set of booklets comprises publications on the following committees: investment, buildings and grounds, academic affairs, student affairs, finance, development, trustees, audit, compensation, and executive. It is part of the AGB Board Basics Series. This report describes the primary role of an audit committee. The primary…

  14. 77 FR 59888 - General Conference Committee of the National Poultry Improvement Plan

    Science.gov (United States)

    2012-10-01

    ... Improvement Plan AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION: Notice of intent to renew... the General Conference Committee of the National Poultry Improvement Plan (Committee) for a 2year... Improvement Plan, VS, APHIS, USDA, 1506 Klondike Road, Suite 300, Conyers, GA 30094; (770) 922-3496...

  15. 77 FR 31393 - Labor Advisory Committee for Trade Negotiations and Trade Policy

    Science.gov (United States)

    2012-05-25

    ... DEPARTMENT OF LABOR Office of the Secretary Labor Advisory Committee for Trade Negotiations and Trade Policy ACTION: Notice of renewal. SUMMARY: Pursuant to the Federal Advisory Committee Act (FACA), as amended (5 U.S.C. App. 2), the Secretary of Labor and the United States Trade Representative have...

  16. 76 FR 71378 - Labor Advisory Committee for Trade Negotiations and Trade Policy

    Science.gov (United States)

    2011-11-17

    ... DEPARTMENT OF LABOR Office of the Secretary Labor Advisory Committee for Trade Negotiations and Trade Policy ACTION: Meeting notice. SUMMARY: Pursuant to the provisions of the Federal Advisory... Committee for Trade Negotiation and Trade Policy. Date, Time, Place: November 30, 2011; 2-4:30 p.m.; U.S...

  17. 77 FR 65581 - Labor Advisory Committee for Trade Negotiations and Trade Policy

    Science.gov (United States)

    2012-10-29

    ... DEPARTMENT OF LABOR Office of the Secretary Labor Advisory Committee for Trade Negotiations and Trade Policy ACTION: Meeting notice. SUMMARY: Pursuant to the provisions of the Federal Advisory... Committee for Trade Negotiation and Trade Policy. Date, Time, Place: November 13, 2012; 10:00 a.m.-12:00 p.m...

  18. 76 FR 72688 - Meeting of the Defense Advisory Committee on Women in the Services (DACOWITS)

    Science.gov (United States)

    2011-11-25

    ... of the Secretary Meeting of the Defense Advisory Committee on Women in the Services (DACOWITS) AGENCY: Department of Defense. ACTION: Notice. SUMMARY: Pursuant to Section 10(a), Public Law 92-463, as amended, notice is hereby given of a forthcoming meeting of the Defense Advisory Committee on Women in the...

  19. 77 FR 32601 - Meeting of the Defense Advisory Committee on Women in the Services (DACOWITS)

    Science.gov (United States)

    2012-06-01

    ... of the Secretary Meeting of the Defense Advisory Committee on Women in the Services (DACOWITS) AGENCY: Department of Defense. ACTION: Notice. SUMMARY: Pursuant to Section 10(a), Public Law 92-463, as amended, notice is hereby given of a forthcoming meeting of the Defense Advisory Committee on Women in the...

  20. 78 FR 13029 - Meeting of the Defense Advisory Committee on Women in the Services (DACOWITS)

    Science.gov (United States)

    2013-02-26

    ... of the Secretary Meeting of the Defense Advisory Committee on Women in the Services (DACOWITS) AGENCY: Department of Defense. ACTION: Notice. SUMMARY: Pursuant to Section 10(a), Public Law 92-463, as amended, notice is hereby given of a forthcoming meeting of the Defense Advisory Committee on Women in the...

  1. 76 FR 55653 - Meeting of the Defense Advisory Committee on Women in the Services (DACOWITS)

    Science.gov (United States)

    2011-09-08

    ... of the Secretary Meeting of the Defense Advisory Committee on Women in the Services (DACOWITS) AGENCY: Department of Defense. ACTION: Notice. SUMMARY: Pursuant to Section 10 (a), Public Law 92-463, as amended, notice is hereby given of a forthcoming meeting of the Defense Advisory Committee on Women in the...

  2. 76 FR 8351 - Meeting of the Defense Department Advisory Committee on Women in the Services (DACOWITS)

    Science.gov (United States)

    2011-02-14

    ... of the Secretary Meeting of the Defense Department Advisory Committee on Women in the Services (DACOWITS) AGENCY: Department of Defense. ACTION: Notice. SUMMARY: Pursuant to Section 10(a), Public Law 92... Committee on Women in the Services (DACOWITS). The meeting is open to the public, subject to the...

  3. 75 FR 78758 - Bureau of International Labor Affairs; Labor Advisory Committee for Trade Negotiations and Trade...

    Science.gov (United States)

    2010-12-16

    ... Committee for Trade Negotiations and Trade Policy ACTION: Meeting notice. SUMMARY: Pursuant to the... meeting of the Labor Advisory Committee for Trade Negotiation and Trade Policy. Date, Time, Place: January 12, 2011; 10 a.m.-11:30 a.m.; U.S. Department of Labor, Secretary's Conference Room, 200 Constitution...

  4. 77 FR 20054 - Bureau of International Labor Affairs; Labor Advisory Committee for Trade Negotiations and Trade...

    Science.gov (United States)

    2012-04-03

    ... Committee for Trade Negotiations and Trade Policy ACTION: Meeting Notice. SUMMARY: Pursuant to the... meeting of the Labor Advisory Committee for Trade Negotiation and Trade Policy. Date, Time, Place: May 14, 2012; 2 p.m.-4 p.m.; U.S. Department of Labor, Secretary's Conference Room, 200 Constitution Ave. NW...

  5. 75 FR 9615 - Bureau of International Labor Affairs: Labor Advisory Committee for Trade Negotiations and Trade...

    Science.gov (United States)

    2010-03-03

    ... Committee for Trade Negotiations and Trade Policy ACTION: Meeting Notice. SUMMARY: Pursuant to the... meeting of the Labor Advisory Committee for Trade Negotiation and Trade Policy. Date, Time, Place: March... Constitution Ave., NW., Washington, DC. Purpose: The meeting will include a review and discussion of current...

  6. 77 FR 29316 - Marine Protected Areas Federal Advisory Committee; Public Meeting

    Science.gov (United States)

    2012-05-17

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Marine Protected Areas.... ACTION: Notice of open meeting. SUMMARY: Notice is hereby given of a meeting of the Marine Protected Areas Federal Advisory Committee (Committee) in Silver Spring, Maryland. DATES: The meeting will be held...

  7. 75 FR 6656 - SFIREG Pesticide Operations and Management Working Committee Meeting

    Science.gov (United States)

    2010-02-10

    ... Evaluation Group (SFIREG), Pesticide Operations and Management (POM) Working Committee will hold a 2-day... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0001; FRL-8811-3] SFIREG Pesticide Operations and Management Working Committee Meeting AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY...

  8. 76 FR 37371 - Ocean Energy Safety Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-06-27

    ...) Ocean Energy Safety Advisory Committee; Notice of Meeting AGENCY: Bureau of Ocean Energy Management, Regulation and Enforcement (BOEMRE), Interior. ACTION: Notice of meeting. SUMMARY: The Ocean Energy Safety Advisory Committee will meet at the Astor Crowne Plaza Hotel in New Orleans, Louisiana. DATES: Wednesday...

  9. 75 FR 23223 - Meetings of the Agricultural Policy Advisory Committee for Trade and the Agricultural Technical...

    Science.gov (United States)

    2010-05-03

    ... Foreign Agricultural Service Meetings of the Agricultural Policy Advisory Committee for Trade and the Agricultural Technical Advisory Committees for Trade AGENCY: Foreign Agricultural Service, USDA. ACTION: Notice... compromise the development by the U.S. government of trade policy priorities, negotiating objectives, or...

  10. 78 FR 22025 - Eighteenth Meeting: RTCA Special Committee 214, Standards for Air Traffic Data Communication...

    Science.gov (United States)

    2013-04-12

    ... Data Communication Services AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: RTCA Special Committee 214, Standards for Air Traffic Data Communication Services... Committee 214, Standards for Air Traffic Data Communication Services. DATES: The meeting will be held May 8...

  11. 75 FR 2581 - Eighty-First Meeting: RTCA Special Committee 159: Global Positioning System (GPS)

    Science.gov (United States)

    2010-01-15

    ... Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 159 meeting: Global Positioning System (GPS). SUMMARY: The FAA is... System (GPS). DATES: The meeting will be held February 2-5, 2010, from 9 a.m. to 4:30 p.m. (unless stated...

  12. 76 FR 27744 - Eighty-Fifth Meeting: RTCA Special Committee 159: Global Positioning System (GPS)

    Science.gov (United States)

    2011-05-12

    ... Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 159 meeting: Global Positioning System (GPS). SUMMARY: The FAA is... System (GPS). DATES: The meeting will be held May 26, 2011, from 9 a.m. to 11:45 a.m. ADDRESSES: The...

  13. 76 FR 33022 - Eighty-Sixth Meeting: RTCA Special Committee 159: Global Positioning System (GPS)

    Science.gov (United States)

    2011-06-07

    ... Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 159 meeting: Global Positioning System (GPS). SUMMARY: The FAA is... System (GPS). DATES: The meeting will be held June 13-17, 2011, from 9 a.m. to 4:30 p.m. ADDRESSES: The...

  14. 76 FR 66997 - NASA Advisory Council; Technology and Innovation Committee; Meeting

    Science.gov (United States)

    2011-10-28

    ... (NASA) announces a meeting of the Technology and Innovation Committee of the NASA Advisory Council (NAC... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (11-106)] NASA Advisory Council; Technology and Innovation Committee; Meeting ACTION: Notice of meeting. SUMMARY: In accordance with the Federal...

  15. 75 FR 13783 - Maritime Advisory Committee for Occupational Safety and Health (MACOSH)

    Science.gov (United States)

    2010-03-23

    ... DEPARTMENT OF LABOR Occupational Safety and Health Administration Maritime Advisory Committee for.... ACTION: MACOSH meeting; Notice. SUMMARY: The Maritime Advisory Committee for Occupational Safety and... occupational safety and health in the maritime industries. The purpose of this Federal Register notice is to...

  16. 78 FR 50085 - Advisory Committee on Climate Change and Natural Resource Science

    Science.gov (United States)

    2013-08-16

    ... Climate Change and Natural Resource Science AGENCY: U.S. Geological Survey, Interior. ACTION: Meeting.... 2, we announce that the Advisory Committee on Climate Change and Natural Resource Science will hold... INFORMATION: Chartered in May 2013, the Advisory Committee on Climate Change and Natural Resource Science...

  17. 78 FR 79478 - Advisory Committee on Climate Change and Natural Resource Science

    Science.gov (United States)

    2013-12-30

    ... Change and Natural Resource Science AGENCY: U.S. Geological Survey, Interior. ACTION: Meeting notice... announce that the Advisory Committee on Climate Change and Natural Resource Science will hold a meeting...: Chartered in May 2013, the Advisory Committee on Climate Change and Natural Resource Science (ACCCNRS...

  18. 76 FR 37199 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2011-06-24

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... Income Tax Credit Project Committee will be held Monday, August 22, 2011, at 3 p.m. Eastern Time via...

  19. 76 FR 45006 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2011-07-27

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... Panel Earned Income Tax Credit Project Committee will be held Monday, September 26, 2011, at 3 p.m...

  20. 76 FR 63716 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2011-10-13

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS) Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... Earned Income Tax Credit Project Committee will be held Monday, November 28, 2011, at 3 p.m. Eastern Time...

  1. 76 FR 10944 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2011-02-28

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee will be held Tuesday...

  2. 76 FR 6188 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2011-02-03

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of meeting. SUMMARY: An open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... Panel Earned Income Tax Credit Project Committee will be held Monday, March 28, 2011, at 2 p.m., Eastern...

  3. 75 FR 47349 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2010-08-05

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS), Treasury ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... Income Tax Credit Project Committee will be held Wednesday, September 22, 2010, at 1 p.m. Eastern Time...

  4. 75 FR 55406 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2010-09-10

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS) Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... Income Tax Credit Project Committee will be held Wednesday, October 27, 2010, at 1:00 p.m. Eastern Time...

  5. 76 FR 56879 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2011-09-14

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS) Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... Earned Income Tax Credit Project Committee will be held Monday, October 24, 2011, at 3 p.m. Eastern Time...

  6. 75 FR 62632 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2010-10-12

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... Income Tax Credit Project Committee will be held Wednesday, November 24, 2010, at 1 p.m. Eastern Time via...

  7. 75 FR 11998 - Open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Issue Committee

    Science.gov (United States)

    2010-03-12

    ... Earned Income Tax Credit Issue Committee AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of Meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Issue... Advocacy Panel Earned Income Tax Credit Issue Committee will be held Tuesday, April 20, 2010 from 8 a.m. to...

  8. 75 FR 39333 - Open Meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Project Committee

    Science.gov (United States)

    2010-07-08

    ... Earned Income Tax Credit Project Committee AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit... Income Tax Credit Project Committee will be held Wednesday, August 25, 2010, at 1 p.m. Eastern Time via...

  9. 78 FR 70259 - 2013-2015 Fruit and Vegetable Industry Advisory Committee

    Science.gov (United States)

    2013-11-25

    ... Agricultural Marketing Service 2013-2015 Fruit and Vegetable Industry Advisory Committee AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice; call for nominations. SUMMARY: Pursuant to the Federal Advisory Committee Act, the Agricultural Marketing Service (AMS) is announcing a call for nominations to the Fruit...

  10. 76 FR 41196 - National Forests in Mississippi, Tombigbee and Holly Springs Resource Advisory Committee

    Science.gov (United States)

    2011-07-13

    ... DEPARTMENT OF AGRICULTURE Forest Service National Forests in Mississippi, Tombigbee and Holly Springs Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tombigbee and Holly Springs National Forests Resource Advisory Committee will meet in Starkville, MS. The...

  11. 76 FR 41195 - National Forests In Mississippi, Tombigbee and Holly Springs Resource Advisory Committee

    Science.gov (United States)

    2011-07-13

    ... DEPARTMENT OF AGRICULTURE Forest Service National Forests In Mississippi, Tombigbee and Holly Springs Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Tombigbee and Holly Springs National Forests Resource Advisory Committee will meet in Starkville, MS. The...

  12. 76 FR 80355 - Energy Efficiency and Renewable Energy Advisory Committee (ERAC)

    Science.gov (United States)

    2011-12-23

    ... DEPARTMENT OF ENERGY Energy Efficiency and Renewable Energy Advisory Committee (ERAC) AGENCY: Department of Energy, Office of Energy Efficiency and Renewable Energy. ACTION: Notice of open teleconference... efficiency and renewable energy. The Federal Advisory Committee Act, Public Law 92- 463, 86 Stat. 770...

  13. 75 FR 80886 - Third Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Science.gov (United States)

    2010-12-23

    ... 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held January 13, 2011...

  14. 76 FR 50811 - Eighth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Science.gov (United States)

    2011-08-16

    ... Committee 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems. SUMMARY...: Airport Security Access Control Systems. DATES: The meeting will be held September 15, 2011, from 10 a.m...

  15. 75 FR 61819 - First Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Science.gov (United States)

    2010-10-06

    ... 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held November 2, 2010...

  16. 76 FR 9632 - Fifth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Science.gov (United States)

    2011-02-18

    ... 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held March 10, 2011, from...

  17. 76 FR 16470 - Sixth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Science.gov (United States)

    2011-03-23

    ... 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems DATES: The meeting will be held April 13, 2011, from...

  18. 76 FR 3599 - Renewal of the Advisory Committee on Biotechnology and 21st Century Agriculture

    Science.gov (United States)

    2011-01-20

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Research Service Renewal of the Advisory Committee on Biotechnology and 21st Century Agriculture AGENCY: Office of the Under Secretary, Research, Education, and Economics, USDA. ACTION: Notice. SUMMARY: The Secretary of Agriculture intends to renew the Advisory Committee on...

  19. 78 FR 7387 - Advisory Committee on Biotechnology and 21st Century Agriculture; Renewal

    Science.gov (United States)

    2013-02-01

    ...; ] DEPARTMENT OF AGRICULTURE Advisory Committee on Biotechnology and 21st Century Agriculture; Renewal AGENCY: Agricultural Research Service, USDA. ACTION: Advisory Committee on Biotechnology and 21st Century Agriculture Renewal. SUMMARY: Notice is hereby given that the Secretary of Agriculture has renewed the Advisory...

  20. 78 FR 17232 - Meeting of the SANE/SART AI/AN Initiative Committee

    Science.gov (United States)

    2013-03-20

    .../SART AI/AN Initiative Committee AGENCY: Office for Victims of Crime, Justice. ACTION: Notice of meeting. SUMMARY: The National Coordination Committee on the American Indian/ Alaska Native (AI/AN) Sexual Assault... violence within AI/AN communities. DATES AND LOCATIONS: The meeting will be held via webinar on Wednesday...

  1. 78 FR 8684 - Twelfth Meeting: RTCA Special Committee 222, Inmarsat AMS(R)S

    Science.gov (United States)

    2013-02-06

    ... Committee 222, Inmarsat AMS(R)S AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 222, Inmarsat AMS(R)S. SUMMARY: The FAA is..., Inmarsat AMS(R)S. DATES: The meeting will be held February 20, 2013, from 1:00 p.m.--4:00 p.m. ADDRESSES...

  2. 77 FR 62538 - Advisory Committee on the Medical Uses of Isotopes: Call for Nominations

    Science.gov (United States)

    2012-10-15

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on the Medical Uses of Isotopes: Call for Nominations AGENCY: U.S. Nuclear Regulatory Commission. ACTION: Call for nominations. SUMMARY: The U.S... administrator and nuclear cardiologist on the Advisory Committee on the Medical Uses of Isotopes (ACMUI...

  3. 76 FR 17362 - Advisory Committee on the Medical Uses of Isotopes: Meeting

    Science.gov (United States)

    2011-03-29

    ... Committee on the Medical Uses of Isotopes: Meeting AGENCY: U.S. Nuclear Regulatory Commission (NRC). ACTION: Notice of meeting. SUMMARY: NRC will convene a meeting of the Advisory Committee on the Medical Uses of Isotopes (ACMUI) on April 11-12, 2011. This will be a public meeting, and the final agenda is under...

  4. 78 FR 25320 - Advisory Committee on the Medical Uses of Isotopes: Meeting Notice

    Science.gov (United States)

    2013-04-30

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on the Medical Uses of Isotopes: Meeting Notice AGENCY: U.S. Nuclear Regulatory Commission. ACTION: Notice of meeting. SUMMARY: The U.S. Nuclear... Uses of Isotopes (ACMUI) on June 18, 2013, to discuss the committee's analysis of reported medical...

  5. 76 FR 59768 - Advisory Committee on International Postal and Delivery Services

    Science.gov (United States)

    2011-09-27

    ... Postal and Delivery Services scheduled for September 29, 2011, and announced in the Federal Register on... DEPARTMENT OF STATE [Public Notice 6808] Advisory Committee on International Postal and Delivery Services AGENCY: Department of State. ACTION: Notice; advisory committee meeting cancellation. SUMMARY: The...

  6. 77 FR 67677 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2012-11-13

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-095] NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Meeting. SUMMARY: In accordance with the Federal Advisory Committee Act, Public Law 92-463, as...

  7. 77 FR 9997 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2012-02-21

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12- 017)] NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of meeting. SUMMARY: In accordance with the Federal Advisory Committee Act, Public Law 92-463, as...

  8. 75 FR 17437 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2010-04-06

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-040)] NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of meeting. SUMMARY: In accordance with the Federal Advisory Committee Act, Public Law 92-463, as...

  9. 76 FR 20717 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2011-04-13

    ... Center), and must state that they are attending the Audit, Finance, and Analysis Committee meeting in... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (11-036)] NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION...

  10. 75 FR 41240 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting.

    Science.gov (United States)

    2010-07-15

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-081)] NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting. AGENCY: National Aeronautics and Space Administration. ACTION: Notice of meeting. SUMMARY: In accordance with the Federal Advisory Committee Act, Public Law 92-463, as...

  11. 77 FR 38679 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2012-06-28

    ... and must state that they are attending the NAC's Audit, Finance and Analysis Committee meeting in... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-053)] NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION...

  12. 78 FR 20696 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2013-04-05

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-043] NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Meeting. SUMMARY: In accordance with the Federal Advisory Committee Act, Public Law 92-463, as...

  13. 77 FR 76072 - Hearings of the Judicial Conference Advisory Committee on Rules of Bankruptcy Procedure; Federal...

    Science.gov (United States)

    2012-12-26

    ... UNITED STATES Hearings of the Judicial Conference Advisory Committee on Rules of Bankruptcy Procedure... States, Advisory Committee on Rules of Bankruptcy Procedure. ACTION: Notice of Cancellation of Open Hearing. SUMMARY: The following public hearing on proposed amendments to the Federal Rules of Bankruptcy...

  14. 78 FR 27405 - Anesthetic and Analgesic Drug Products Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-05-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001... Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug Administration (FDA). The meeting will be open to the public. Name of Committee...

  15. 78 FR 29142 - Anesthetic and Analgesic Drug Products Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-05-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001... Administration, HHS. ACTION: Notice. This notice announces a forthcoming meeting of a public advisory committee of the Food and Drug Administration (FDA). The meeting will be open to the public. Name of Committee...

  16. 75 FR 10845 - Subcommittee on Forensic Science; Committee on Science; National Science and Technology Council

    Science.gov (United States)

    2010-03-09

    ... OFFICE OF SCIENCE AND TECHNOLOGY POLICY Subcommittee on Forensic Science; Committee on Science; National Science and Technology Council ACTION: General Notice. Nominations for Interagency Working Group participants. SUMMARY: The Subcommittee on Forensic Science of the National Science and Technology Council's...

  17. 77 FR 32699 - NASA Advisory Council; Aeronautics Committee; UAS Subcommittee Meeting

    Science.gov (United States)

    2012-06-01

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-039] NASA Advisory Council; Aeronautics Committee; UAS Subcommittee Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of..., the National Aeronautics and Space Administration (NASA) announces a meeting of the Unmanned Aircraft...

  18. 76 FR 42160 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-07-18

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Space Transportation Operations Working Group of the Commercial Space Transportation Advisory...

  19. 77 FR 56681 - Nanoscale Science, Engineering, and Technology Subcommittee; Committee on Technology, National...

    Science.gov (United States)

    2012-09-13

    ... OFFICE OF SCIENCE AND TECHNOLOGY POLICY Nanoscale Science, Engineering, and Technology Subcommittee; Committee on Technology, National Science and Technology Council; Public Engagement Through Nano.gov Webinar AGENCY: Executive Office of the President, Office of Science and Technology Policy. ACTION...

  20. 77 FR 9705 - NASA Advisory Council; Technology and Innovation Committee; Meeting

    Science.gov (United States)

    2012-02-17

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-013] NASA Advisory Council; Technology and Innovation Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... amended, the National Aeronautics and Space Administration (NASA) announces a meeting of the Technology...

  1. 75 FR 61519 - NASA Advisory Council; Technology and Innovation Committee; Meeting

    Science.gov (United States)

    2010-10-05

    ... Space Technology Program planning and review innovation activities at NASA's Langley Research Center... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-117)] NASA Advisory Council; Technology and Innovation Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION...

  2. 76 FR 19793 - NASA Advisory Council; Technology and Innovation Committee; Meeting

    Science.gov (United States)

    2011-04-08

    ... transfer and licensing activities update. --Update on technology and innovation in NASA Commercial and... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (11-031)] NASA Advisory Council; Technology and Innovation Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION...

  3. 75 FR 41240 - NASA Advisory Council; Technology and Innovation Committee; Meeting

    Science.gov (United States)

    2010-07-15

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-080)] NASA Advisory Council; Technology and Innovation Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: N... amended, the National Aeronautics and Space Administration announces a meeting of the Technology and...

  4. 76 FR 54806 - Maritime Advisory Committee for Occupational Safety and Health (MACOSH)

    Science.gov (United States)

    2011-09-02

    ... DEPARTMENT OF LABOR Occupational Safety and Health Administration [Docket No. OSHA-2011-0007] Maritime Advisory Committee for Occupational Safety and Health (MACOSH) AGENCY: Occupational Safety and Health Administration (OSHA), Labor. ACTION: Notice of MACOSH Meeting. SUMMARY: The Maritime Advisory...

  5. 76 FR 38428 - Maritime Advisory Committee for Occupational Safety and Health (MACOSH)

    Science.gov (United States)

    2011-06-30

    ... DEPARTMENT OF LABOR Occupational Safety and Health Administration [Docket No OSHA-2011-0007] Maritime Advisory Committee for Occupational Safety and Health (MACOSH) AGENCY: Occupational Safety and Health Administration (OSHA), Labor. ACTION: Notice of MACOSH meeting. SUMMARY: The Maritime Advisory...

  6. 76 FR 58077 - Seventy-Third Meeting: RTCA Special Committee 147: Minimum Operational Performance Standards for...

    Science.gov (United States)

    2011-09-19

    ..., etc. ASIAS/CAST/CAS Steering Committee Working Group Status Reports Requirement Working Group Detailed... Reference Other Business Action Items Date, Time, and Place of Next meeting Adjourn Attendance is open to...

  7. 76 FR 52016 - NASA International Space Station Advisory Committee and the Aerospace Safety Advisory Panel; Meeting

    Science.gov (United States)

    2011-08-19

    ... consideration by NASA for Commercial Resupply Services for the International Space Station (ISS), with... SPACE ADMINISTRATION NASA International Space Station Advisory Committee and the Aerospace Safety Advisory Panel; Meeting AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of...

  8. 77 FR 60005 - Aviation Rulemaking Advisory Committee Meeting on Transport Airplane and Engine Issues

    Science.gov (United States)

    2012-10-01

    ... Engine Issues AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of public meeting...) to discuss transport airplane and engine (TAE) issues. It also withdraws the notice entitled, ``Aviation Rulemaking Advisory Committee Meeting on Transport Airplane and Engine Issues'', published on...

  9. 76 FR 62496 - Motor Carrier Safety Advisory Committee Series of Public Subcommittee Meetings

    Science.gov (United States)

    2011-10-07

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006-26367] Motor Carrier Safety Advisory Committee Series of Public Subcommittee Meetings AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of meeting. SUMMARY: The FMCSA's Motor...

  10. 77 FR 60507 - Motor Carrier Safety Advisory Committee (MCSAC): Public Subcommittee Meeting

    Science.gov (United States)

    2012-10-03

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006-26367] Motor Carrier Safety Advisory Committee (MCSAC): Public Subcommittee Meeting AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of Meeting of Compliance, Safety...

  11. 78 FR 5243 - Motor Carrier Safety Advisory Committee (MCSAC): Public Meeting of Subcommittees

    Science.gov (United States)

    2013-01-24

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006-26367] Motor Carrier Safety Advisory Committee (MCSAC): Public Meeting of Subcommittees AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of meeting of Motor Carrier Safety...

  12. 76 FR 5424 - Motor Carrier Safety Advisory Committee; Request for Nominations

    Science.gov (United States)

    2011-01-31

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006-26367] Motor Carrier Safety Advisory Committee; Request for Nominations AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Request for Nominations to the Motor Carrier Safety Advisory...

  13. 77 FR 51845 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-08-27

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory..., development, and implementation of intelligent transportation systems. Through its sponsor, the ITS Joint...

  14. 77 FR 20872 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-04-06

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory..., development, and implementation of intelligent transportation systems. Through its sponsor, the ITS Joint...

  15. 78 FR 64048 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-10-25

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory... implementation of intelligent transportation systems. Through its sponsor, the ITS Joint Program Office (JPO...

  16. 77 FR 26067 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-05-02

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory... of intelligent transportation systems. Through its sponsor, the ITS Joint Program Office, the ITS PAC...

  17. 77 FR 57640 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-09-18

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory... intelligent transportation systems. Through its sponsor, the ITS Joint Program Office, the ITS PAC makes...

  18. 78 FR 24241 - Nanoscale Science, Engineering, and Technology Subcommittee; Committee on Technology, National...

    Science.gov (United States)

    2013-04-24

    ... TECHNOLOGY POLICY Nanoscale Science, Engineering, and Technology Subcommittee; Committee on Technology, National Science and Technology Council; Notice of Public Meeting AGENCY: Executive Office of the President, Office of Science and Technology Policy. ACTION: Notice of Public Meeting. SUMMARY: The National...

  19. 76 FR 11798 - Advisory Committee on Organ Transplantation; Notice of Meeting

    Science.gov (United States)

    2011-03-03

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Advisory Committee on Organ Transplantation; Notice of Meeting AGENCY: Health Resources and Services Administration, HHS. ACTION: Notice; correction. SUMMARY: The Health Resources and Services Administration published a...

  20. 77 FR 51580 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Science.gov (United States)

    2012-08-24

    ... unwarranted invasion of personal privacy.] 10:45 a.m.-11 a.m.: Reconciliation of ACRS Comments and..., insights gained from these events, and any follow-up actions by the Subcommittee and/or the Full Committee...

  1. Critical operator actions: human reliability modeling and data issues. Principal Working Group No. 5 - Task 94-1. Final Task Report prepared by a Group of Experts of the NEA Committee on the Safety of Nuclear Installations

    International Nuclear Information System (INIS)

    Wilmart, P.; Grant, A.; Raina, V.M.; Patrik, M.; Cacciabue, P.C.; Cojazzi, G.; Reiman, L.; Virolainen, R.; Lanore, J.M.; Poidevin, S.; Herttrich, P.M.; Mertens, J.; Reer, B.; Straeter, O.; Bareith, A.; Hollo, E.; Traini, E.; Fukuda, M.; Hirano, M.; Kani, Y.; Muramatsu, K.; Versteeg, M.F.; Kim, T.W.; Calvo, J.; Gil, B.; Dang, V.N.; Hirschberg, S.; Meyer, P.; Schmocker, U.; Andrews, R.; Coxson, B.; Shepherd, C.H.; Murphy, J.A.; Parry, G.W.; Ramey-Smith, A.; Siu, N.O.

    1998-01-01

    The treatment of human interactions is considered one of the major limitations in the context of Probabilistic Safety Assessment (PSA).While the results of many PSAs show a very significant contribution of human errors, large uncertainties are normally associated with the quantitative estimates of these contributors. This problem becomes even more significant when analysing human interactions under special conditions, for example in accident scenarios for external events or for the shutdown and low power conditions. Any improvement in the current state of knowledge with respect to the data for human interactions would have a positive impact on the confidence in PSA results, including correct ranking of the dominant accident scenarios. At the same time many PSAs have been successful at identifying critical operator actions; in most cases the benefits of these qualitative insights are not jeopardised by lack of numerical precision in the estimates. The present HRA approaches as generally applied in PSAs are also limited in scope; for instance, they either ignore errors of commissions or treat these superficially. New, dynamic methods, primarily aiming at the resolution of the issues of cognitive errors including errors of commission are emerging but their full-scope applications within the PSA framework belong to the future. In the context of data, some progress has been observed partially due to use of simulators to support the human reliability analysis (HRA). These applications have been rather concentrated (but not limited) to France and USA. Recently, a very promising program has been established in Hungary. The experiences from such applications are not widely known and dissemination of the relevant insights to the PSA community has some definite merits. With respect to the identification of critical operator actions there is in some cases clear evidence and in others a good potential that the existing PSA studies may provide useful, partially generic

  2. 78 FR 6087 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2013-01-29

    ... Biological and Environmental Research Advisory Committee AGENCY: Office of Science, Department of Energy. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Biological and.... Department of Energy, Office of Science, Office of Biological and Environmental Research, SC-23/Germantown...

  3. 77 FR 4028 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2012-01-26

    ... Biological and Environmental Research Advisory Committee AGENCY: Department of Energy; Office of Science. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Biological and... of Biological and Environmental Research, SC-23/Germantown Building, 1000 Independence Avenue SW...

  4. installation of the ITER committee industry. Participants guide

    International Nuclear Information System (INIS)

    2006-01-01

    ITER is an international project to design and build an experimental fusion reactor based on the tokamak concept. This guide presents the ITER project and objectives and the associated organizations in France, the recommendations and actions for ITER, the industrial mobilization, the industrial committee and its members, technological sheets for the enterprises and the statistical document of the SESSI. (A.L.B.)

  5. 75 FR 5281 - Notice of Resource Advisory Committee Meeting

    Science.gov (United States)

    2010-02-02

    ...: Modoc County Resource Advisory Committee, Alturas, California 96101, USDA Forest Service. ACTION: Notice..., 2010 and March 8, 2010 in Alturas, California 96101, for a business meeting. The meetings are open to... begin at 4 p.m., at the Modoc National Forest Office, Conference Room, 800 West 12th St., Alturas...

  6. 76 FR 37312 - Fruit and Vegetable Industry Advisory Committee

    Science.gov (United States)

    2011-06-27

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service Fruit and Vegetable Industry Advisory Committee AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice of Reestablishment of the U.S. Department of... industry's needs. The Deputy Administrator of the Agricultural Marketing Service's Fruit and Vegetable...

  7. 75 FR 71450 - Oncologic Drugs Advisory Committee; Amendment of Notice

    Science.gov (United States)

    2010-11-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-N-0001] Oncologic Drugs Advisory Committee; Amendment of Notice AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing an amendment to the notice of a...

  8. 77 FR 37911 - Oncologic Drugs Advisory Committee; Amendment of Notice

    Science.gov (United States)

    2012-06-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Oncologic Drugs Advisory Committee; Amendment of Notice AGENCY: Food and Drug Administration, HHS. ACTION: Notice. The Food and Drug Administration (FDA) is announcing an amendment to the notice of meeting of the...

  9. 76 FR 23513 - Wholesale Pork Reporting Negotiated Rulemaking Committee

    Science.gov (United States)

    2011-04-27

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 59 Wholesale Pork Reporting Negotiated Rulemaking Committee AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice of negotiated rulemaking... Holiday Inn National Airport/Crystal City Hotel; 2650 Jefferson Davis Highway; Arlington, VA 22202; Phone...

  10. 77 FR 48204 - Minority Depository Institution Advisory Committee

    Science.gov (United States)

    2012-08-13

    ... DEPARTMENT OF THE TREASURY Office of the Comptroller of the Currency [Docket ID: OCC-2012-0012] Minority Depository Institution Advisory Committee AGENCY: Office of the Comptroller of the Currency, Department of the Treasury. ACTION: Notice. SUMMARY: The Comptroller of the Currency has determined that the...

  11. 77 FR 40914 - Arts and Artifacts Indemnity Panel Advisory Committee

    Science.gov (United States)

    2012-07-11

    ... ARTS AND THE HUMANITIES Arts and Artifacts Indemnity Panel Advisory Committee AGENCY: Federal Council on the Arts and the Humanities, National Endowment for the Humanities, National Foundation on the Arts and the Humanities. ACTION: Notice of meeting. SUMMARY: Pursuant to section 10(a)(2) of the...

  12. 77 FR 64146 - Arts and Artifacts Indemnity Panel Advisory Committee

    Science.gov (United States)

    2012-10-18

    ... ARTS AND THE HUMANITIES Arts and Artifacts Indemnity Panel Advisory Committee AGENCY: Federal Council on the Arts and the Humanities, National Endowment for the Humanities. ACTION: Notice of meeting... hereby given that the Federal Council on the Arts and the Humanities will hold a meeting of the Arts and...

  13. 78 FR 4878 - Arts and Artifacts Indemnity Panel Advisory Committee

    Science.gov (United States)

    2013-01-23

    ... ARTS AND THE HUMANITIES Arts and Artifacts Indemnity Panel Advisory Committee AGENCY: Federal Council on the Arts and the Humanities; National Endowment for the Humanities. ACTION: Notice of meeting... hereby given that the Federal Council on the Arts and the Humanities will hold a meeting of the Arts and...

  14. 77 FR 15994 - Southern Region Recreation Resource Advisory Committee

    Science.gov (United States)

    2012-03-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Southern Region Recreation Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting via teleconference. SUMMARY: The Southern Region... and requests to Southern Region Recreation RAC, Caroline Mitchell, P.O. Box 1270, Hot Springs, AR...

  15. 77 FR 18792 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2012-03-28

    ... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction... should be sent to National Earthquake Hazards Reduction Program Director, National Institute of Standards...

  16. 77 FR 75610 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2012-12-21

    ... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction... meeting on the National Earthquake Hazards Reduction Program (NEHRP) Web site at http://nehrp.gov...

  17. 76 FR 72905 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2011-11-28

    ... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction.... ADDRESSES: Questions regarding the meeting should be sent to National Earthquake Hazards Reduction Program...

  18. 77 FR 27439 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2012-05-10

    ... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction... should be sent to National Earthquake Hazards Reduction Program Director, National Institute of Standards...

  19. 76 FR 64325 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2011-10-18

    ... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction... relationship of Presidential Policy Directive/PPD-8: National Preparedness to National Earthquake Hazards...

  20. 77 FR 19224 - Advisory Committee on Earthquake Hazards Reduction Meeting

    Science.gov (United States)

    2012-03-30

    ... Earthquake Hazards Reduction Meeting AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of open meeting. SUMMARY: The Advisory Committee on Earthquake Hazards Reduction... should be sent to National Earthquake Hazards Reduction Program Director, National Institute of Standards...