77 FR 10786 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Reliability...

Science.gov (United States)

2012-02-23

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Reliability and PRA; Notice of Meeting The ACRS Subcommittee on Reliability and PRA will hold a... Modeling Application Guide.'' The Subcommittee will hear presentations by and hold discussions with the NRC...

75 FR 27841 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR

Science.gov (United States)

2010-05-18

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR The ACRS Subcommittee on EPR will hold a meeting on May 21, 2010, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public attendance. The agenda for...

MRI quality assurance using the ACR phantom in a multi-unit imaging center

International Nuclear Information System (INIS)

Ihalainen, Toni M.; Kuusela, Linda J.; Savolainen, Sauli E.; Loennroth, Nadja T.; Peltonen, Juha I.; Uusi-Simola, Jouni K.; Timonen, Marjut H.; Sipilae, Outi E.

2011-01-01

Background. Magnetic resonance imaging (MRI) instrumentation is vulnerable to technical and image quality problems, and quality assurance is essential. In the studied regional imaging center the long-term quality assurance has been based on MagNET phantom measurements. American College of Radiology (ACR) has an accreditation program including a standardized image quality measurement protocol and phantom. The ACR protocol includes recommended acceptance criteria for clinical sequences and thus provides possibility to assess the clinical relevance of quality assurance. The purpose of this study was to test the ACR MRI phantom in quality assurance of a multi-unit imaging center. Material and methods. The imaging center operates 11 MRI systems of three major manufacturers with field strengths of 3.0 T, 1.5 T and 1.0 T. Images of the ACR phantom were acquired using a head coil following the ACR scanning instructions. Both ACR T1- and T2-weighted sequences as well as T1- and T2-weighted brain sequences in clinical use at each site were acquired. Measurements were performed twice. The images were analyzed and the results were compared with the ACR acceptance levels. Results. The acquisition procedure with the ACR phantom was faster than with the MagNET phantoms. On the first and second measurement rounds 91% and 73% of the systems passed the ACR test. Measured slice thickness accuracies were not within the acceptance limits in site T2 sequences. Differences in the high contrast spatial resolution between the ACR and the site sequences were observed. In 3.0 T systems the image intensity uniformity was slightly lower than the ACR acceptance limit. Conclusion. The ACR method was feasible in quality assurance of a multi-unit imaging center and the ACR protocol could replace the MagNET phantom tests. An automatic analysis of the images will further improve cost-effectiveness and objectiveness of the ACR protocol

75 FR 7633 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice...

Science.gov (United States)

2010-02-22

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice of Meeting The ACRS U.S. Evolutionary Power Reactor (EPR) Subcommittee will hold a....S. EPR Design Certification Document Review. The Subcommittee will gather information, analyze...

75 FR 12804 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice...

Science.gov (United States)

2010-03-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice of Meeting The ACRS U.S. Evolutionary Power Reactor (EPR) Subcommittee will hold a... Chapters 11 and 16 of the Safety Evaluation Report with Open Items associated with the U.S. EPR Design...

The ACR Model

DEFF Research Database (Denmark)

Bec, Frederique; Rahbek, Anders Christian; Shephard, Neil

2008-01-01

This paper proposes and analyses the autoregressive conditional root (ACR) time-series model. This multivariate dynamic mixture autoregression allows for non-stationary epochs. It proves to be an appealing alternative to existing nonlinear models, e.g. the threshold autoregressive or Markov...... switching class of models, which are commonly used to describe nonlinear dynamics as implied by arbitrage in presence of transaction costs. Simple conditions on the parameters of the ACR process and its innovations are shown to imply geometric ergodicity, stationarity and existence of moments. Furthermore...

77 FR 74696 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP-1000...

Science.gov (United States)

2012-12-17

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP-1000; Notice of Meeting The ACRS Subcommittee on AP-1000 will hold a meeting on January 18, 2013, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public...

Strategy for 100-year life of the ACR-1000 concrete containment structure

International Nuclear Information System (INIS)

Abrishami, H.; Elgohary, M.

2006-01-01

The purpose of this paper is to present the Plant Life Management (PLiM) strategy for the concrete containment structure of the ACR-1000 (Advanced CANDU Reactor) designed by AECL. The ACR-1000 is designed for 100-year plant life including 60-year operating life and additional 40-year decommissioning period of time. The approach adopted for the PLiM strategy of the concrete containment structure is a preventive one, key areas being: 1) design methodology, 2) material performance and 3) life cycle management and ageing management program. In the design phase, in addition to strength and serviceability, durability is a major requirement during the service life and decommissioning phase of the ACR structure. Parameters affecting durability design include: a) concrete performance, b) structural application, and c) environmental conditions. Due to the complex nature of the environmental effects acting on structures during the service life of project, it is considered that true improved performance during the service life can be achieved by improving the material characteristics. Many recent innovations in advanced concrete materials technology have made it possible to produce modern concrete such as high-performance concrete with exceptional performance characteristics. In this paper, the PLiM strategy for the ACR-1000 concrete containment is presented. In addition to addressing the design methodology and material performance areas, a systematic approach for ageing management program for the concrete containment structure is presented. (author)

ACR-1000 design provisions for severe accidents

International Nuclear Information System (INIS)

Popov, N.K.; Santamaura, P.; Shapiro, H.; Snell, V.G.

2006-01-01

Atomic Energy of Canada Limited (AECL) developed the Advanced CANDU Reactor-700 (ACR-700) as an evolutionary advancement of the current CANDU 6 reactor. As a further advancement of the ACR design, AECL is currently developing the ACR-1000 for the Canadian and international market. The ACR-1000 is aimed at producing electrical power for a capital cost and a unit-energy cost significantly less than that of the current generation of operating nuclear plants, while achieving enhanced safety features, shorter construction schedule, high plant capacity factor, improved operations and maintenance, and increased operating life. The reference ACR-1000 plant design is based on an integrated two-unit plant, using enriched fuel and light-water coolant, with each unit having a nominal gross output of about 1200 MWe. The ACR-1000 design meets Canadian regulatory requirements and follows established international practice with respect to severe accident prevention and mitigation. This paper presents the ACR-1000 features that are designed to mitigate limited core damage and severe core damage states, including core retention within vessel, core damage termination, and containment integrity maintenance. While maintaining existing structures of CANDU reactors that provide inherent prevention and retention of core debris, the ACR-1000 design includes additional features for prevention and mitigation of severe accidents. Core retention within vessel in CANDU-type reactors includes both retention within fuel channels, and retention within the calandria vessel. The ACR-1000 calandria vessel design permits for passive rejection of decay heat from the moderator to the shield water. Also, the calandria vessel is designed for debris retention by minimizing penetrations at the bottom periphery and by accommodating thermal and weight loads of the core debris. The ACR-1000 containment is required to withstand external events such as earthquakes, tornados, floods and aircraft crashes

WE-AB-206-02: ACR Ultrasound Accreditation: Requirements and Pitfalls

International Nuclear Information System (INIS)

Walter, J.

2016-01-01

The involvement of medical physicists in diagnostic ultrasound imaging service is increasing due to QC and accreditation requirements. The goal of this ultrasound hands-on workshop is to demonstrate quality control (QC) testing in diagnostic ultrasound and to provide updates in ACR ultrasound accreditation requirements. The first half of this workshop will include two presentations reviewing diagnostic ultrasound QA/QC and ACR ultrasound accreditation requirements. The second half of the workshop will include live demonstrations of basic QC tests. An array of ultrasound testing phantoms and ultrasound scanners will be available for attendees to learn diagnostic ultrasound QC in a hands-on environment with live demonstrations and on-site instructors. The targeted attendees are medical physicists in diagnostic imaging. Learning Objectives: Gain familiarity with common elements of a QA/QC program for diagnostic ultrasound imaging dentify QC tools available for testing diagnostic ultrasound systems and learn how to use these tools Learn ACR ultrasound accreditation requirements Jennifer Walter is an employee of American College of Radiology on Ultrasound Accreditation.

77 FR 14465 - Public Transportation on Indian Reservations Program; Tribal Transit Program

Science.gov (United States)

2012-03-09

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Public Transportation on Indian... in funding provided by the Public Transportation on Indian Reservations Program (Tribal Transit... establishing the Public Transportation on Indian Reservations Program (Tribal Transit Program or TTP). This...

Finding of no significant impact: Changes in the sanitary sludge land application program on the Oak Ridge Reservation, Oak Ridge, Tennessee

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-10-01

The U.S. Department of Energy (DOE) has completed an environmental assessment (DOE/EA-1042) that evaluates potential impacts of proposed changes in the sanitary sludge land application program on the DOE Oak Ridge Reservation (ORR), Oak Ridge, Tennessee. Changes in lifetime sludge land application limits and radionuclide loading are proposed, and two new sources of sewage sludge from DOE facilities would be transported to the City of Oak Ridge Publicly Owned Treatment Works (COR POTW). Lifetime sludge land application limits would increase from 22 tons/acre to 50 tons/acre, which is the limit approved and permitted by the Tennessee Department of Environment and Conservation (TDEC). With the approval of TDEC, the permissible radiological dose from sludge land application would change from the current limit of 2x background radionuclide concentrations in receiving soils to a risk-based dose limit of 4 millirem (mrem) per year for the maximally exposed individual. Sludge land application sites would not change from those that are currently part of the program. Based on the results of the analysis reported in the EA, DOE has determined that the proposed action is not a major federal action that would significantly affect the quality of the human environment within the context of the National Environmental Policy Act of 1969 (NEPA). Therefore, preparation of an environmental impact statement (EIS) is not necessary, and DOE is issuing this Finding of No Significant Impact (FONSI). 70 refs., 2 figs., 17 tabs.

Finding of no significant impact: Changes in the sanitary sludge land application program on the Oak Ridge Reservation, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1996-10-01

The U.S. Department of Energy (DOE) has completed an environmental assessment (DOE/EA-1042) that evaluates potential impacts of proposed changes in the sanitary sludge land application program on the DOE Oak Ridge Reservation (ORR), Oak Ridge, Tennessee. Changes in lifetime sludge land application limits and radionuclide loading are proposed, and two new sources of sewage sludge from DOE facilities would be transported to the City of Oak Ridge Publicly Owned Treatment Works (COR POTW). Lifetime sludge land application limits would increase from 22 tons/acre to 50 tons/acre, which is the limit approved and permitted by the Tennessee Department of Environment and Conservation (TDEC). With the approval of TDEC, the permissible radiological dose from sludge land application would change from the current limit of 2x background radionuclide concentrations in receiving soils to a risk-based dose limit of 4 millirem (mrem) per year for the maximally exposed individual. Sludge land application sites would not change from those that are currently part of the program. Based on the results of the analysis reported in the EA, DOE has determined that the proposed action is not a major federal action that would significantly affect the quality of the human environment within the context of the National Environmental Policy Act of 1969 (NEPA). Therefore, preparation of an environmental impact statement (EIS) is not necessary, and DOE is issuing this Finding of No Significant Impact (FONSI). 70 refs., 2 figs., 17 tabs

Calculation program development for spinning reserve

International Nuclear Information System (INIS)

1979-01-01

This study is about optimal holding of spinning reserve and optimal operation for it. It deals with the purpose and contents of the study, introduction of the spinning reserve electricity, speciality of the spinning reserve power, the result of calculation, analysis for limited method of optimum load, calculation of requirement for spinning reserve, analysis on measurement of system stability with summary, purpose of the analysis, cause of impact of the accident, basics on measurement of spinning reserve and conclusion. It has the reference on explanation for design of spinning reserve power program and using and trend about spinning reserve power in Korea.

Impact of modules on the ACR construction schedule

International Nuclear Information System (INIS)

Choy, Ed; Elgohary, Medhat; Fairclough, Neville; Yu, Stephen; Murayama, Kouichi; Miura, Jun; Kawahata, Junichi

2003-01-01

The ACR (Advanced CANDU Reactor), developed by Atomic Energy of Canada Ltd. (AECL), is designed with constructability considerations as a major requirement during all project phases from the concept design stage to the detail design stage. For ACR-700, a project schedule of 48 months has been developed for the nth replicated unit with a 36 month construction period duration from First Concrete to Fuel Load. AECL, recognizing the immense benefit of collective experience, is partnering with Hitachi Ltd in the development of the ACR power plant design. AECL has gained valuable experience in implementing new construction methods at the Qinshan (Phase III) twin unit CANDU 6 plant in China, and Hitachi likewise has enjoyed success in modular construction of ABWRs in Japan. Utilizing these experiences, AECL is developing the ACR nuclear steam plant (NSP) and Hitachi is developing the Turbine Building. An overall construction strategy, which builds on the success of these construction methods from the nuclear power plant developments in China and Japan, has been developed for the ACR. The overall construction strategy comprises the 'Open Top' construction technique using a Very Heavy Lift crane, parallel construction activities, with extensive modularization and prefabrication. Modules and prefabrications are major features of the ACR design, resulting in an excess of 80% of Reactor Building internal work being completed as modules or as very streamlined traditional construction. This paper reviews the ACR construction strategy and provides examples of modules and how they impact on the ACR construction schedule. In conclusion, the ACR-700 is designed using the latest, proven construction methods to achieve a 36 month construction period for the nth replicated unit. (author)

The radiology job market: analysis of the ACR jobs board.

Science.gov (United States)

Prabhakar, Anand M; Oklu, Rahmi; Harvey, H Benjamin; Harisinghani, Mukesh G; Rosman, David A

2014-05-01

The aim of this study was to assess the status of the radiology job market as represented by the ACR Jobs Board from October 2010 to June 2013. With the assistance of the ACR, data from the ACR Jobs Board from October 2010 through June 2013, including the numbers of monthly new job seekers, new job postings, and job posting clicks, were gathered and used to calculate a monthly competitive index, defined as the ratio of new job seekers to new job postings. During the study period, the mean number of new job seekers was 168 per month, which was significantly greater than the 84 average new job postings for any given month (P = .0002). There was no significant difference between 2011 and 2012 with regard to the number of new job seekers or job postings. Over the time period assessed, more new job seekers registered in October and November 2010, August to November 2011, and October and November 2012. These periods were also associated with the highest competitive index values. There were less job seekers in the winter and spring of 2011, 2012, and 2013, periods associated with lower competitive index values. ACR Jobs Board activity, measured by job posting clicks, was significantly higher in 2012 than in 2011 (P Jobs Board, there were consistently more new job seekers than job postings throughout the study period, and fall is the period in the year most associated with the highest competitive index for radiologist employment. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

ACR-1000TM Project - Licensing Opportunities and Challenges

International Nuclear Information System (INIS)

Popov, N.; Doerffer, S.; Ion, R.; Hopwood, J.

2011-01-01

Atomic Energy of Canada Limited (AECL) has developed the Advanced CANDU Reactor TM 1 1000 (ACR-1000 TM ) as an evolutionary advancement of the current CANDU 6 reactor. The ACR-1000 design has evolved from AECL's in-depth knowledge of CANDU TM systems, components, and materials, as well as the experience and feedback received from owners and operators of CANDU plants. The ACR design retains the proven strengths and features of CANDU reactors, while incorporating innovations and state-of-the-art technology. It also features major improvements in economics, inherent safety characteristics, and performance, while retaining the proven benefits of the CANDU family of nuclear power plants. To ensure that the ACR design is compliant with Canadian and international requirements, regulatory pre-project reviews of the ACR-1000 (and ACR-700 TM 1 with lower output) were conducted early in the design work. The regulatory feedback from these pre-project regulatory reviews helped AECL to better understand regulatory expectations in Canada, US and the UK, and to make further advancements and improvements in the ACR design to meet the Canadian and international regulatory requirements. This paper provides an overview of the key design features of the ACR-1000 reactor design, and summary of the pre-project reviews by those above-mentioned regulatory bodies, demonstrating opportunities and challenges in licensing process of and pointing to the importance of efficient vendor-regulator interaction. (author)

Seismic design features of the ACR Nuclear Power Plant

International Nuclear Information System (INIS)

Elgohary, M.; Saudy, A.; Aziz, T.

2003-01-01

Through their worldwide operating records, CANDU Nuclear Power Plants (NPPs) have repeatedly demonstrated safe, reliable and competitive performance. Currently, there are fourteen CANDU 6 single unit reactors operating or under construction worldwide. Atomic Energy of Canada Limited's (AECL) Advanced CANDU Reactor - the ACR. - is the genesis of a new generation of technologically advanced reactors founded on the CANDU reactor concept. The ACR is the next step in the evolution of the CANDU product line. The ACR products (ACR-700 and ACR-1000) are based on CANDU 6 (700 MWe class) and CANDU 9 (900 MWe class) reactors, therefore continuing AECL's successful approach of offering CANDU plants that appeal to a broad segment of the power generation market. The ACR products are based on the proven CANDU technology and incorporate advanced design technologies. The ACR NPP seismic design complies with Canadian standards that were specifically developed for nuclear seismic design and also with relevant International Atomic Energy Agency (IAEA) Safety Design Standards and Guides. However, since the ACR is also being offered to several markets with many potential sites and different regulatory environments, there is a need to develop a comprehensive approach for the seismic design input parameters. These input parameters are used in the design of the standard ACR product that is suitable for many sites while also maintaining its economic competitiveness. For this purpose, the ACR standard plant is conservatively qualified for a Design Basis Earthquake (DBE) with a peak horizontal ground acceleration of 0.3g for a wide range of soil/rock foundation conditions and Ground Response Spectra (GRS). These input parameters also address some of the current technical issues such as high frequency content and near field effects. In this paper, the ACR seismic design philosophy and seismic design approach for meeting the safety design requirements are reviewed. Also the seismic design

7 CFR 1412.44 - Notification of base acres.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Notification of base acres. 1412.44 Section 1412.44... through 2012 § 1412.44 Notification of base acres. The operator and owners of record of a farm will be notified in writing of the number of base acres eligible for enrollment in a contract, unless such operator...

Advanced construction methods in ACR

International Nuclear Information System (INIS)

Elgohary, M.; Choy, E.; Yu, S.K.W.

2002-01-01

The ACR - Advanced CANDU Reactor, developed by Atomic Energy of Canada Limited (AECL), is designed with constructability considerations as a major requirement during all project phases from the concept design stage to the detail design stage. This necessitated a much more comprehensive approach in including constructability considerations in the design to ensure that the construction duration is met. For the ACR-700, a project schedule of 48 months has been developed for the nth replicated unit with a 36 month construction period duration from First Concrete to Fuel Load. An overall construction strategy that builds on the success of the construction methods that are proven in the construction of the Qinshan CANDU 6 project has been developed for the ACR. The overall construction strategy comprises the 'Open Top' construction technique using a Very Heavy Lift crane, parallel construction activities, with extensive modularization and prefabrication. In addition, significant applications of up to date construction technology will be implemented, e.g. large volume concrete pours, prefabricated rebar, use of climbing forms, composite structures, prefabricated permanent formwork, automatic welding, and utilization of the latest electronic technology tools such as 3D CADDs modelling yields a very high quality, clash free product to allow construction to be completed 'right the first time' and eliminates rework. Integration of 3D CADDs models and scheduling tools such as Primavera has allowed development of actual construction sequences and an iterative approach to schedule verification and improvement. Modularization and prefabrication are major features of the ACR design in order to achieve the project schedule. For the reactor building approximately 80% of the volume will be installed as modules or prefabricated assembles. This ensures critical path activities are achieved. This paper examines the advanced construction methods implemented in the design in order to

ACR-700 advanced technologies

International Nuclear Information System (INIS)

Tapping, R.L.; Turner, C.W.; Yu, S.K.W.; Olmstead, R.; Speranzini, R.A.

2004-01-01

A successful advanced reactor plant will have optimized economics including reduced operating and maintenance costs, improved performance, and enhanced safety. Incorporating improvements based on advanced technologies ensures cost, safety and operational competitiveness of the ACR-700. These advanced technologies include modern configuration management; construction technologies; operational technology for the control centre and information systems for plant monitoring and analysis. This paper summarizes the advanced technologies used to achieve construction and operational improvements to enhance plant economic competitiveness, advances in the operational technology used for reactor control, and presents the development of the Smart CANDU suite of tools and its application to existing operating reactors and to the ACR-700. (author)

Family Forest Ownerships with 10+ Acres in Texas, 2011-2013

Science.gov (United States)

Brett J. Butler; Sarah M. Butler

2016-01-01

The U.S. Forest Service, Forest Inventory and Analysis program conducts the National Woodland Owner Survey in order to better understand: who owns America's forests, why they own it, what they have done with it in the past, and what they intend to do with it in the future. This document summarizes data on family forest ownerships with 10+ acres in Texas. These...

Family Forest Ownerships with 10+ Acres in Pennsylvania, 2011-2013

Science.gov (United States)

Brett J. Butler; Sarah M. Butler

2016-01-01

The U.S. Forest Service, Forest Inventory and Analysis program conducts the National Woodland Owner Survey in order to better understand: who owns America's forests, why they own it, what they have done with it in the past, and what they intend to do with it in the future. This document summarizes data on family forest ownerships with 10+ acres in Pennsylvania....

Functional relevance of AcrB Trimerization in pump assembly and substrate binding.

Directory of Open Access Journals (Sweden)

Wei Lu

Full Text Available AcrB is a multidrug transporter in the inner membrane of Escherichia coli. It is an obligate homotrimer and forms a tripartite efflux complex with AcrA and TolC. AcrB is the engine of the efflux machinery and determines substrate specificity. Active efflux depends on several functional features including proton translocation across the inner membrane through a proton relay pathway in the transmembrane domain of AcrB; substrate binding and migration through the substrate translocation pathway; the interaction of AcrB with AcrA and TolC; and the formation of AcrB homotrimer. Here we investigated two aspects of the inter-correlation between these functional features, the dependence of AcrA-AcrB interaction on AcrB trimerization, and the reliance of substrate binding and penetration on protein-protein interaction. Interaction between AcrA and AcrB was investigated through chemical crosslinking, and a previously established in vivo fluorescent labeling method was used to probe substrate binding. Our data suggested that dissociation of the AcrB trimer drastically decreased its interaction with AcrA. In addition, while substrate binding with AcrB seemed to be irrelevant to the presence or absence of AcrA and TolC, the capability of trimerization and conduction of proton influx did affect substrate binding at selected sites along the substrate translocation pathway in AcrB.

Identifying efficiency trends for Queensland broad-acre beef enterprises

OpenAIRE

Gregg, Daniel; Rolfe, John

2010-01-01

Productivity and efficiency improvements in agriculture have recently been targeted as Federal Government priorities in Australia. This research examined a dataset of 116 broad-acre beef enterprises from Queensland who participated in a program, Profit Probe, developed to improve management and profitability of enterprises. The aim of this research was to identify the sources, if any, of productivity growth for this sample of enterprises. Two potential sources of productivity growth were iden...

ACRE: Absolute concentration robustness exploration in module-based combinatorial networks

KAUST Repository

Kuwahara, Hiroyuki; Umarov, Ramzan; Almasri, Islam; Gao, Xin

2017-01-01

To engineer cells for industrial-scale application, a deep understanding of how to design molecular control mechanisms to tightly maintain functional stability under various fluctuations is crucial. Absolute concentration robustness (ACR) is a category of robustness in reaction network models in which the steady-state concentration of a molecular species is guaranteed to be invariant even with perturbations in the other molecular species in the network. Here, we introduce a software tool, absolute concentration robustness explorer (ACRE), which efficiently explores combinatorial biochemical networks for the ACR property. ACRE has a user-friendly interface, and it can facilitate efficient analysis of key structural features that guarantee the presence and the absence of the ACR property from combinatorial networks. Such analysis is expected to be useful in synthetic biology as it can increase our understanding of how to design molecular mechanisms to tightly control the concentration of molecular species. ACRE is freely available at https://github.com/ramzan1990/ACRE.

ACRE: Absolute concentration robustness exploration in module-based combinatorial networks

KAUST Repository

Kuwahara, Hiroyuki

2017-03-01

To engineer cells for industrial-scale application, a deep understanding of how to design molecular control mechanisms to tightly maintain functional stability under various fluctuations is crucial. Absolute concentration robustness (ACR) is a category of robustness in reaction network models in which the steady-state concentration of a molecular species is guaranteed to be invariant even with perturbations in the other molecular species in the network. Here, we introduce a software tool, absolute concentration robustness explorer (ACRE), which efficiently explores combinatorial biochemical networks for the ACR property. ACRE has a user-friendly interface, and it can facilitate efficient analysis of key structural features that guarantee the presence and the absence of the ACR property from combinatorial networks. Such analysis is expected to be useful in synthetic biology as it can increase our understanding of how to design molecular mechanisms to tightly control the concentration of molecular species. ACRE is freely available at https://github.com/ramzan1990/ACRE.

ACRES At-Risk Task Force: Dropout Survey.

Science.gov (United States)

Bull, Kay S.; And Others

This paper describes a study by the American Council on Rural Special Education (ACRES) to determine its membership's opinions on priorities and expertise regarding the dropout problem. ACRES members, primarily rural special-education teachers, parents, and collateral service workers, were surveyed about the dropout problem and what research they…

The Automated Conflict Resolution System (ACRS)

Science.gov (United States)

Kaplan, Ted; Musliner, Andrew; Wampler, David

1993-01-01

The Automated Conflict Resolution System (ACRS) is a mission-current scheduling aid that predicts periods of mutual interference when two or more orbiting spacecraft are scheduled to communicate with the same Tracking and Data Relay Satellite (TDRS) at the same time. The mutual interference predicted has the potential to degrade or prevent communications. Thus the ACRS system is a useful tool for aiding in the scheduling of Space Network (SN) communications.

Habitat reclamation plan to mitigate for the loss of habitat due to oil and gas production activities under maximum efficient rate, Naval Petroleum Reserve No. 1, Kern County, California

International Nuclear Information System (INIS)

Anderson, D.C.

1994-11-01

Activities associated with oil and gas development under the Maximum Efficiency Rate (MER) from 1975 to 2025 will disturb approximately 3,354 acres. Based on 1976 aerial photographs and using a dot grid methodology, the amount of land disturbed prior to MER is estimated to be 3,603 acres. Disturbances on Naval Petroleum Reserve No. 1 (NPR-1) were mapped using 1988 aerial photography and a geographical information system. A total of 6,079 acres were classified as disturbed as of June, 1988. The overall objective of this document is to provide specific information relating to the on-site habitat restoration program at NPRC. The specific objectives, which relate to the terms and conditions that must be met by DOE as a means of protecting the San Joaquin kit fox from incidental take are to: (1) determine the amount and location of disturbed lands on NPR-1 and the number of acres disturbed as a result of MER activities, (2) develop a long term (10 year) program to restore an equivalent on-site acres to that lost from prior project-related actions, and (3) examine alternative means to offset kit fox habitat loss

Comparison of Urine Albumin-to-Creatinine Ratio (ACR) Between ACR Strip Test and Quantitative Test in Prediabetes and Diabetes

Science.gov (United States)

Cho, Seon; Kim, Suyoung; Cho, Han-Ik

2017-01-01

Background Albuminuria is generally known as a sensitive marker of renal and cardiovascular dysfunction. It can be used to help predict the occurrence of nephropathy and cardiovascular disorders in diabetes. Individuals with prediabetes have a tendency to develop macrovascular and microvascular pathology, resulting in an increased risk of retinopathy, cardiovascular diseases, and chronic renal diseases. We evaluated the clinical value of a strip test for measuring the urinary albumin-to-creatinine ratio (ACR) in prediabetes and diabetes. Methods Spot urine samples were obtained from 226 prediabetic and 275 diabetic subjects during regular health checkups. Urinary ACR was measured by using strip and laboratory quantitative tests. Results The positive rates of albuminuria measured by using the ACR strip test were 15.5% (microalbuminuria, 14.6%; macroalbuminuria, 0.9%) and 30.5% (microalbuminuria, 25.1%; macroalbuminuria, 5.5%) in prediabetes and diabetes, respectively. In the prediabetic population, the sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of the ACR strip method were 92.0%, 94.0%, 65.7%, 99.0%, and 93.8%, respectively; the corresponding values in the diabetic population were 80.0%, 91.6%, 81.0%, 91.1%, and 88.0%, respectively. The median [interquartile range] ACR values in the strip tests for measurement ranges of 300 mg/g were 9.4 [6.3-15.4], 46.9 [26.5-87.7], and 368.8 [296.2-575.2] mg/g, respectively, using the laboratory method. Conclusions The ACR strip test showed high sensitivity, specificity, and negative predictive value, suggesting that the test can be used to screen for albuminuria in cases of prediabetes and diabetes. PMID:27834062

Unfolding study of a trimeric membrane protein AcrB.

Science.gov (United States)

Ye, Cui; Wang, Zhaoshuai; Lu, Wei; Wei, Yinan

2014-07-01

The folding of a multi-domain trimeric α-helical membrane protein, Escherichia coli inner membrane protein AcrB, was investigated. AcrB contains both a transmembrane domain and a large periplasmic domain. Protein unfolding in sodium dodecyl sulfate (SDS) and urea was monitored using the intrinsic fluorescence and circular dichroism spectroscopy. The SDS denaturation curve displayed a sigmoidal profile, which could be fitted with a two-state unfolding model. To investigate the unfolding of separate domains, a triple mutant was created, in which all three Trp residues in the transmembrane domain were replaced with Phe. The SDS unfolding profile of the mutant was comparable to that of the wild type AcrB, suggesting that the observed signal change was largely originated from the unfolding of the soluble domain. Strengthening of trimer association through the introduction of an inter-subunit disulfide bond had little effect on the unfolding profile, suggesting that trimer dissociation was not the rate-limiting step in unfolding monitored by fluorescence emission. Under our experimental condition, AcrB unfolding was not reversible. Furthermore, we experimented with the refolding of a monomeric mutant, AcrBΔloop , from the SDS unfolded state. The CD spectrum of the refolded AcrBΔloop superimposed well onto the spectra of the original folded protein, while the fluorescence spectrum was not fully recovered. In summary, our results suggested that the unfolding of the trimeric AcrB started with a local structural rearrangement. While the refolding of secondary structure in individual monomers could be achieved, the re-association of the trimer might be the limiting factor to obtain folded wild-type AcrB. © 2014 The Protein Society.

76 FR 44394 - Public Transportation on Indian Reservations Program; Tribal Transit Program

Science.gov (United States)

2011-07-25

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Public Transportation on Indian... the Public Transportation on Indian Reservations Program (Tribal Transit Program) (TTP). This program... of the Census and may be used for public transportation capital projects, operating costs of...

Brownfields/IGD: EF_ACRES

Data.gov (United States)

U.S. Environmental Protection Agency — EF_ACRES is a subset of facilities from FRS_INTEREST and FRS_FACILITY_SITE which are updated on a monthly basis as part of the Locational Reference Tables (LRT)...

The Prevalence of acrA and acrB Genes Among Multiple-Drug Resistant Uropathogenic Escherichia coli Isolated From Patients With UTI in Milad Hospital, Tehran

Directory of Open Access Journals (Sweden)

Maleki

2016-09-01

Full Text Available Background Urinary tract infection (UTI is one of the most common infectious diseases and nosocomial infections worldwide, and uropathogenic Escherichia coli is the primary cause of UTI. Due to increased antibiotic resistance and the emergence of multidrug resistant (MDR UPEC clones, the treatment of UTI is difficult. The occurrence of MDR in E. coli has been attributed to the AcrAB-TolC complex of efflux pumps. Objectives The aim of this study was to complete a frequency evaluation of acrA and acrB genes among UPEC MDR strains isolated from patients with UTI who were admitted to Milad hospital in Tehran. Methods For 123 UPEC strains that were isolated and diagnosed from the urine samples of patients using biochemical tests, antibiotic susceptibility was carried out using the disc diffusion method according to CLSI guidelines. Isolates that were resistant to at least one antimicrobial agent in three or more of the categories were considered to be MDR. The presence and frequency of acrA and acrB genes was determined using PCR. Results The rates of antibiotic resistance to ampicillin, cefalotin, tetracycline, cefazolin, ceftriaxone, ceftizoxime, ceftazidime, ciprofloxacin, and cotrimoxazole were 82.9%, 78.1%, 61.1%, 49.5%, 38.2%, 30.2%, 26.1%, 42.2%, and 60.1%, respectively. The isolates were most sensitive to nitrofurantoin (95.9%, gentamicin (77.2%, and amikacin (71.5%. A total of 78% of the isolates were MDR. The frequency of the acrA gene was 82.90%, the acrB gene was 95.90% and acrA + acrB was 95.90%. There was no significant difference between acrA and acrB frequency relating to bacterial antibiotic resistance. Conclusions Our results showed that ways to control the treatment of UTI for the prevention of MDR occurrence should be sought. For a better study of efflux pumps, a comprehensive and detailed study regarding the presence of efflux pumps gees is required.

Steam generator design requirements for ACR-1000

International Nuclear Information System (INIS)

Subash, S.; Hau, K.

2006-01-01

Atomic Energy of Canada Limited (AECL) has developed the ACR-1000 (Advanced CANDU Reactor-1000 ) to meet market expectations for enhanced safety of plant operation, high capacity factor, low operating cost, increased operating life, simple component replacement, reduced capital cost, and shorter construction schedule. The ACR-1000 design is based on the use of horizontal fuel channels surrounded by a heavy water moderator, the same feature as in all CANDU reactors. The major innovation in the ACR-1000 is the use of low enriched uranium fuel, and light water as the coolant, which circulates in the fuel channels. This results in a compact reactor core design and a reduction of heavy water inventory, both contributing to a significant decrease in capital cost per MWe produced. The ACR-1000 plant is a two-unit, integrated plant with each unit having a nominal gross output of about 1165 MWe with a net output of approximately 1085 MWe. The plant design is adaptable to a single unit configuration, if required. This paper focuses on the technical considerations that went into developing some of the important design requirements for the steam generators for the ACR-1000 plant and how these requirements are specified in the Technical Specification, which is the governing document for the steam generator (SG) detail design. Layout of these SGs in the plant is briefly described and their impacts on the SG design. (author)

The advantages of PD1 activating chimeric receptor (PD1-ACR) engineered lymphocytes for PDL1(+) cancer therapy.

Science.gov (United States)

Tang, Xiaolong; Li, Qingguo; Zhu, Yongqiang; Zheng, Donghui; Dai, Jingjing; Ni, Wenxuan; Wei, Jia; Xue, Yubao; Chen, Ke; Hou, Wei; Zhang, Chao; Feng, Xiaojun; Liang, Yong

2015-01-01

Tumors exploit immunoregulatory checkpoints to attenuate T cell responses as a means of circumventing immunologic rejection. By activating the inhibitory costimulatory pathway of Programmed Death 1 (PD1)/PDL1 which provides tumor cells an escape mechanism from immune surveillance, Programmed Death Ligand1 (PDL1)(+) tumors hamper activated tumor-specific T cell functions and render them functionally exhausted. To overcome the inhibitory costimulatory effects of PDL1 on the adoptively transferred T cells, we sought to convert PD1 to a T cell costimulatory receptor by exchanging its transmembrane and cytoplasmic tail with CD28 and 4-1BB signaling domains (PD1-CD28-4-1BB, PD1-ACR), anticipating the genetically modified effector T lymphocytes expressing PD1-ACR would exhibit enhanced functional attributes. And the results showed that PD1-ACR expressed T cells retained the ability to bind PDL1, resulting in T cell activation as evidenced by the elevated activity of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), the augmentation of cytokine secretion and the increased proliferative capacity. Moreover, when systemically administered in the mouse model of glioblastoma metastases, PD1-ACR T cells localized at the area of U87 invasive tumor, which results in suppressed tumor growth and enhanced survival of mice with established U87 glioblastoma. Together, these data demonstrated that PD1-ACR has a high potential to serve as a novel strategy to overcome PDL1 mediated immunosuppression of T cells for cancer therapy.

Comparing new diagnostic criteria of 2010 ACR/EULAR with 1987 ACR criteria in rheumatoid arthritis

Directory of Open Access Journals (Sweden)

Fatemeh Shirani

2017-01-01

Full Text Available Background: Rheumatoid Arthritis (RA is a chronic inflammatory disease presenting with inflammation, tenderness and destruction of the synovial joints, resulting in severe disability and early death due to complication of disease. Previous diagnostic criteria are not useful for identifying patients who need early treatment. Thus, new diagnostic criteria for faster diagnosis of disease are introduced in 2010. The aim of this study was to compared 1987 ACR (American College of Rheumatology criteria and 2010 ACR/EULAR (European League Against Rheumatism classification criteria for diagnosis of rheumatoid arthritis. Methods: In this Cohort prospective study, patients with early arthritis were evaluated   according to the old and new diagnostic criteria and followed-up every two monthly for one year (2012-2013 in Hazrat-e Rasool University Hospital, Tehran. Inclusion criteria of this study were age more than 18 year and indefinite diagnosis of arthritis. For all of patients physical examination by expert rheumatologist was done and lab data include erythrocyte sedimentation rate (ESR, C-reactive protein (CRP, anti-cyclic citrullinated peptide (Anti-CCP and rheumatoid factor was requested. The sensitivity, specificity, positive and negative predictive values were then determined for each diagnostic criteria. Results: In this study 104 patients including 28 males (26.9% and 76 females (73.1% with the mean age of 44.2±13.7 years were included. At the end of one year follow-up, 82 were diagnosed to have RA while other 22 patients were not categorized as RA. Sensitivity for ESR, CRP, Anti-CCP and rheumatoid factor in 2010 ACR/EULAR criteria was 52%, 19%, 48%, 28% and specificity for them was 45%, 71%, 27%, 79% respectively. Number of small and large joint arthritis were more in patients with Rheumatoid Arthritis (RA rather than other arthritis (P=0.0001. Sensitivity and specificity for small joints involvement was 87% and 54% and for large joints

Women's Leadership in the ACR, 2001-2015.

Science.gov (United States)

Patel, Amy K; Fielding, Julia; Macura, Katarzyna J; Applegate, Kimberly E; Zackula, Rosalee; Arleo, Elizabeth Kagan

2017-06-01

To assess the trends of women in voluntary leadership roles in the ACR from 2001 to 2015. Retrospective leadership records from 2001 to 2015 were collected from the ACR Membership Database based on member demographics, gender, and participation in leadership roles at the national and state level. Data were sorted by gender and year to assess the proportion of women in each leadership position relative to total member/representation counts. Overall, there were increasing numbers of women represented in ACR leadership. From 2001 to 2015, there were increasing rates of women achieving fellowship in the College (7%-11%), now at parity with male member rates. Representation by women has risen from 7% to 21% for state chapter presidents and from 14% to 18% for state councilors. Comparing rolling 5-year averages from 2001-2005 and 2011-2015 showed statistically significant increases (P leadership roles. Women members of the council steering committee rose from 13% in 2001 to 19% in 2015, peaking at 24% in 2014. The Board of Chancellors (BOC) showed the largest increase in women, from 9% to 33%, with a peak at 37% in 2014. However, no BOC chairs were women, one council speaker was a woman, two women were ACR presidents, and two women were vice presidents. Women's participation in ACR leadership has increased significantly at the state level and in fellowship recognition. Although there are increasing numbers of women on the BOC, top positions remain male-dominated at the national level. Published by Elsevier Inc.

ACR: Licensing and design readiness

International Nuclear Information System (INIS)

Alizadeh, A.

2009-01-01

Full text The Canadian nuclear technology has a long history dating back to the 1940s. In this regard, Canada is in a unique situation, shared only by a very few countries, where original nuclear power technology has been invented and further developed. Canadian Nuclear Safety Commission (CNSC), then called AECB, was established in 1946. CNSC focuses on nuclear security, nuclear safety, establishing health and safety regulations, and has also played an instrumental role in the formation of the IAEA. CNSC has provided assistance to the establishment of regulatory authorities in AECL's client countries such as Korea, Argentina, China and Romania. AECL has developed the Gen III+ ACR 1000 as evolutionary advancement of the current CANDU 6 reactor. ACR-1000 has evolved from AECL's in depth experience with CANDU systems, components, and materials, as well as the feedback received from owners and operators of CANDU plants. The ACR-1000 design retains the proven strengths and features of CANDU reactors, while incorporating innovations and state-of-the-art technology. It also features major improvements in economics, inherent safety characteristics, and performance. ACR-1000 has completed its Basic Engineering, has advanced in the licensing process in Canada, and is ready for deployment in Canadian and world markets. EC6 is an evolution of CANDU 6 and is a Gen III natural uranium fuelled reactor. Its medium size and potential for fuel localization and advanced fuel cycles is an optimal strategic solution in many markets.AECL's reactor products are shown to be compliant with a variety of licensing and regulatory requirements. These include the new CNSC DRD-337, IAEA NS-R1, and EUR. This allows the countries interested in CANDU reactor products to be confident of its licensing in their own regulatory regimes.

Endangered Species Program Naval Petroleum Reserves in California

International Nuclear Information System (INIS)

1992-02-01

The Naval Petroleum Reserves in California (NPRC) are operated by the US Department of Energy (DOE). Construction and development activities, which are conducted by DOE at Naval Petroleum Reserve number-sign 1 (NPR-1) to comply with the Naval Petroleum Reserves Production Act of 1976 (Public Law 94-258), potentially threaten the continued existence of four federally-listed endangered species: the San Joaquin kit fox, (Vulpes macrotis mutica), blunt-nosed leopard lizard (Gambelia silus), giant kangaroo rat (Dipodomys ingens), and Tipton kangaroo rat (Dipodomys nitratoides nitratoides). All four are protected under the Endangered Species Act of 1973. The major objective of the Endangered Species Program on NPR-1 and NPR-2 is to provide DOE with the scientific expertise and continuity of programs necessary for continued compliance with the Endangered Species Act. The specific objective of this report is to summarize progress and results of the Endangered Species Program made during Fiscal Year 1990 (FY90)

Constructability - from Qinshan to the ACR

International Nuclear Information System (INIS)

Elgohary, M.; Fairclough, N.; Ricciuti, R.

2003-01-01

AECL has recognised the importance of Constructability for many years and is applying its principals to CANDU projects with increasing success. Constructability is defined as the consideration of construction knowledge and experience during all phases of a project, and recognizes that maximum benefit can be achieved during the concept phases of a project. The CANDU 6 Nuclear Power Plant has been constructed eleven times in the last 25 years, however, the last two units being completed on the Qinshan project in China have employed some very innovative construction methods that have not been used on the previous units. In order to make nuclear power generation more competitive, shorter construction schedules and reduced project costs and risks are essential objectives. The application of constructability principles is a major contributor to achieving these objectives. The success of Qinshan has increased the confidence in the new construction methods which are being implemented on the ACR (Advanced CANDU Reactor) successfully. An ACR construction strategy that utilizes advanced construction techniques has been developed by AECL. The strategy includes paralleling of activities by using extensive modularization and the vertical installation of equipment and modules into the reactor building, using a VHL (Very Heavy Lift) crane. This strategy allows short schedules to be met with a minimum risk to the project. This paper describes the latest construction methods used successfully on the Qinshan CANDU 6 project and looks at the extensive implementation of similar methods for ACR. It is concluded, based on the Qinshan success, that the ACR construction schedule is readily achievable. (author)

Expression of the AcrAB Components of the AcrAB-TolC Multidrug Efflux Pump of Yersinia enterocolitica Is Subject to Dual Regulation by OmpR.

Directory of Open Access Journals (Sweden)

Adrianna Raczkowska

Full Text Available OmpR is a transcriptional regulator implicated in the control of various cellular processes and functions in Enterobacteriaceae. This study was undertaken to identify genes comprising the OmpR regulon in the human gastrointestinal pathogen Yersinia enterocolitica. Derivatives of an ompR-negative strain with random transposon insertions creating transcriptional fusions with the reporter gene lacZ were isolated. These were supplied with the wild-type ompR allele in trans and then screened for OmpR-dependent changes in β-galactosidase activity. Using this strategy, five insertions in genes/operons positively regulated by OmpR and two insertions in genes negatively regulated by this protein were identified. Genetic analysis of one of these fusion strains revealed that the gene acrR, encoding transcriptional repressor AcrR is negatively regulated by OmpR. Differential analysis of membrane proteins by SDS-PAGE followed by mass spectrometry identified the protein AcrB, a component of the AcrAB-TolC multidrug efflux pump, as being positively regulated by OmpR. Analysis of the activity of the acrR and acrAB promoters using gfp fusions confirmed their OmpR-dependent repression and activation, respectively. The identification of putative OmpR-binding sites and electrophoretic mobility shift assays confirmed that this regulator binds specifically to both promoter regions with different affinity. Examination of the activity of the acrR and acrAB promoters after the exposure of cells to different chemicals showed that bile salts can act as an OmpR-independent inducer. Taken together, our findings suggest that OmpR positively controls the expression of the AcrAB-TolC efflux pump involved in the adaptive response of Y. enterocolitica O:9 to different chemical stressors, thus conferring an advantage in particular ecological niches.

Structural and functional aspects of the multidrug efflux pump AcrB.

Science.gov (United States)

Eicher, Thomas; Brandstätter, Lorenz; Pos, Klaas M

2009-08-01

The tripartite efflux system AcrA/AcrB/TolC is the main pump in Escherichia coli for the efflux of multiple antibiotics, dyes, bile salts and detergents. The inner membrane component AcrB is central to substrate recognition and energy transduction and acts as a proton/drug antiporter. Recent structural studies show that homotrimeric AcrB can adopt different monomer conformations representing consecutive states in an allosteric functional rotation transport cycle. The conformational changes create an alternate access drug transport tunnel including a hydrophobic substrate binding pocket in one of the cycle intermediates.

Strategic Petroleum Reserve Program stewardship report No. 1

Energy Technology Data Exchange (ETDEWEB)

None

1978-11-03

This report is a managerial evaluation of the Strategic Petroleum Reserve (SPR) Program conducted by the SPR program director and project manager. Current capabilities and goals of the program have been assessed resulting in an achievable SPR baseline for performance and measurement of this program. Projections and recommendations are based on available technical, schedule, and cost information, taking into account known influencing factors. The SPR Baseline incorporates current critical factors and deviations from the FY 1980 budget data bases. Data on existing sites, expansion sites, turnkey sites, program cost, and withdrawal are included.

Licensing the ACR-700 in the USA

International Nuclear Information System (INIS)

Langman, V.; Ion, R.; Reid, C.; Snell, V.

2003-01-01

Atomic Energy of Canada Ltd. (AECL), via its 100% owned US subsidiary AECL Technologies Inc., is performing a pre-application review of the Advanced CANDU Reactor (ACR) with the US Nuclear Regulatory Commission (USNRC). Completion of this pre-application review by mid-2004, is in support of an application to the USNRC for Standard Design Certification that is targeted for the fall of 2004. The intent of the pre-application review is to deal up-front with potential issues associated with the CANDU reactor genealogy of the ACR that are different from the Light Water Reactor (LWR) and Boiling Water Reactor (BWR) regulatory framework in the USA. The focus of the paper will be to describe the pre-application review process currently underway with the NRC staff. In the context of the pre-application review this paper will provide an overview of the licensing approach being used to introduce the ACR-700 to the USA. (author)

Licensing the ACR-700 in the USA

Energy Technology Data Exchange (ETDEWEB)

Langman, V.; Ion, R. [Atomic Energy of Canada Limited, Mississauga, Ontario (Canada); Reid, C. [Bechtel Power Corporation, San Fransisco, California (United States); Snell, V. [Atomic Energy of Canada Limited, Mississauga, Ontario (Canada)

2003-07-01

Atomic Energy of Canada Ltd. (AECL), via its 100% owned US subsidiary AECL Technologies Inc., is performing a pre-application review of the Advanced CANDU Reactor (ACR) with the US Nuclear Regulatory Commission (USNRC). Completion of this pre-application review by mid-2004, is in support of an application to the USNRC for Standard Design Certification that is targeted for the fall of 2004. The intent of the pre-application review is to deal up-front with potential issues associated with the CANDU reactor genealogy of the ACR that are different from the Light Water Reactor (LWR) and Boiling Water Reactor (BWR) regulatory framework in the USA. The focus of the paper will be to describe the pre-application review process currently underway with the NRC staff. In the context of the pre-application review this paper will provide an overview of the licensing approach being used to introduce the ACR-700 to the USA. (author)

Modeling Human Error Mechanism for Soft Control in Advanced Control Rooms (ACRs)

Energy Technology Data Exchange (ETDEWEB)

Aljneibi, Hanan Salah Ali [Khalifa Univ., Abu Dhabi (United Arab Emirates); Ha, Jun Su; Kang, Seongkeun; Seong, Poong Hyun [KAIST, Daejeon (Korea, Republic of)

2015-10-15

To achieve the switch from conventional analog-based design to digital design in ACRs, a large number of manual operating controls and switches have to be replaced by a few common multi-function devices which is called soft control system. The soft controls in APR-1400 ACRs are classified into safety-grade and non-safety-grade soft controls; each was designed using different and independent input devices in ACRs. The operations using soft controls require operators to perform new tasks which were not necessary in conventional controls such as navigating computerized displays to monitor plant information and control devices. These kinds of computerized displays and soft controls may make operations more convenient but they might cause new types of human error. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or human errors) during NPP operation. The developed model would contribute to a lot of applications to improve human performance (or reduce human errors), HMI designs, and operators' training program in ACRs. The developed model of human error mechanism for the soft control is based on assumptions that a human operator has certain amount of capacity in cognitive resources and if resources required by operating tasks are greater than resources invested by the operator, human error (or poor human performance) is likely to occur (especially in 'slip'); good HMI (Human-machine Interface) design decreases the required resources; operator's skillfulness decreases the required resources; and high vigilance increases the invested resources. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or reduction of human errors) during NPP operation.

Modeling Human Error Mechanism for Soft Control in Advanced Control Rooms (ACRs)

International Nuclear Information System (INIS)

Aljneibi, Hanan Salah Ali; Ha, Jun Su; Kang, Seongkeun; Seong, Poong Hyun

2015-01-01

To achieve the switch from conventional analog-based design to digital design in ACRs, a large number of manual operating controls and switches have to be replaced by a few common multi-function devices which is called soft control system. The soft controls in APR-1400 ACRs are classified into safety-grade and non-safety-grade soft controls; each was designed using different and independent input devices in ACRs. The operations using soft controls require operators to perform new tasks which were not necessary in conventional controls such as navigating computerized displays to monitor plant information and control devices. These kinds of computerized displays and soft controls may make operations more convenient but they might cause new types of human error. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or human errors) during NPP operation. The developed model would contribute to a lot of applications to improve human performance (or reduce human errors), HMI designs, and operators' training program in ACRs. The developed model of human error mechanism for the soft control is based on assumptions that a human operator has certain amount of capacity in cognitive resources and if resources required by operating tasks are greater than resources invested by the operator, human error (or poor human performance) is likely to occur (especially in 'slip'); good HMI (Human-machine Interface) design decreases the required resources; operator's skillfulness decreases the required resources; and high vigilance increases the invested resources. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or reduction of human errors) during NPP operation

76 FR 60938 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Power...

Science.gov (United States)

2011-09-30

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on...) associated with the Nine Mile Point extended power uprate application. The [[Page 60939

77 FR 67439 - Fiscal Year 2013 Public Transportation on Indian Reservations Program

Science.gov (United States)

2012-11-09

... Year 2013 Public Transportation on Indian Reservations Program AGENCY: Federal Transit Administration... changes in the Public Transportation on Indian Reservations program (Tribal Transit Program) in accordance... Public Meeting: FTA will provide outreach in conjunction with the National Tribal Transportation...

WE-D-207-03: CT Protocols for Screening and the ACR Designated Lung Screening Program

International Nuclear Information System (INIS)

McNitt-Gray, M.

2015-01-01

implementing Lung Cancer Screening protocols for CT, including utilizing resources such as the AAPM Protocols and the ACR Designated Lung Screening Center program. UCLA Department of Radiology has an Institutional research agreement with Siemens Healthcare; Dr. McNitt-Gray has been a recipient of Research Support from Siemens Healthcare in the past. Dr. Aberle has been a Member of Advisory Boards for the LUNGevity Foundation (2011-present) and Siemens Medical Solutions. (2013)

ACR appropriateness criteria jaundice.

Science.gov (United States)

Lalani, Tasneem; Couto, Corey A; Rosen, Max P; Baker, Mark E; Blake, Michael A; Cash, Brooks D; Fidler, Jeff L; Greene, Frederick L; Hindman, Nicole M; Katz, Douglas S; Kaur, Harmeet; Miller, Frank H; Qayyum, Aliya; Small, William C; Sudakoff, Gary S; Yaghmai, Vahid; Yarmish, Gail M; Yee, Judy

2013-06-01

A fundamental consideration in the workup of a jaundiced patient is the pretest probability of mechanical obstruction. Ultrasound is the first-line modality to exclude biliary tract obstruction. When mechanical obstruction is present, additional imaging with CT or MRI can clarify etiology, define level of obstruction, stage disease, and guide intervention. When mechanical obstruction is absent, additional imaging can evaluate liver parenchyma for fat and iron deposition and help direct biopsy in cases where underlying parenchymal disease or mass is found. Imaging techniques are reviewed for the following clinical scenarios: (1) the patient with painful jaundice, (2) the patient with painless jaundice, and (3) the patient with a nonmechanical cause for jaundice. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. Copyright © 2013 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Managing Phytophthora ramorum at Bloedel Reserve

Science.gov (United States)

Darren Strenge; Marianne Elliott; Gary Chastagner; Casey Sclar

2017-01-01

Bloedel Reserve is a 150-acre botanical garden and nature preserve on the north end of Bainbridge Island in Washington on the Puget Sound. The grounds encompass undeveloped forest, pastures, a bird marsh, woodland plantings, and intensely maintained gardens within the limits of the City of Bainbridge Island. The garden is part of the Sentinel Plant Network, a...

White paper from the ACR Task Force on Print Media in Radiology.

Science.gov (United States)

Duszak, Richard; Haines, G Rebecca; Van Duyn Wear, Vanessa; Lexa, Frank James; Bashir, Mustafa; D'Souza, Sharon; Carlos, Ruth; Chen, James Yen-Yu; King, Bernard F; Wald, Christoph

2011-10-01

The rapidly changing technological and business environment in which scientific journals are published will necessitate ongoing reassessment of operations, goals, and priorities. In this white paper, the ACR Task Force on Print Media in Radiology reviews the history and role of print media in radiology; discusses current and anticipated societal, technological, and financial challenges; and explores a variety of strategies to help ensure the relevance of professional society publishing in the future. Copyright © 2011 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Endangered Species Program, Naval Petroleum Reserves in California

International Nuclear Information System (INIS)

1992-12-01

Naval Petroleum Reserve No. 1 (NPR-1) is operated by the U. S. Department of Energy (DOE) and Chevron USA (CUSA). Four federally-listed endangered animal species and one federally-threatened plant species are known to occur on the Naval Petroleum Reserves in California (NPRC): the San Joaquin kit fox (Vulpes velox macrotis), blunt-nosed leopard lizard (Gambelia silus), giant kangaroo rat (Dipodomys ingens), Tipton kangaroo rat (Dipodomys nitratoides nitratoides), and Hoover's wooly-star (Eriastrum hooveri). All five are protected under the Endangered Species Act of 1973 (as amended) (Public Law 93-205), which declaresthat it is the policy of Congress that all Federal departments and agencies shall seek to conserve endangered and threatened species and shall utilize their authorities in furtherance of the purposes of the Act. DOE is also obliged to determine whether actions taken by their lessees on Naval Petroleum Reserve No. 2 (NPR-2) will have any effects on endangered species or their habitats. The major objective of the EG ampersand G Energy Measurements, Inc. Endangered Species Program on NPR-1 and NPR-2 is to provide DOE with the scientific expertise and continuity of programs necessary for continued compliance with the Endangered SpeciesAct. The specific objective of this report is to summarize progress and results of the Endangered Species Program made during Fiscal Year 1992 (FY92)

Human intestinal parasites in crusader Acre: Evidence for migration with disease in the medieval period.

Science.gov (United States)

Mitchell, Piers D; Anastasiou, Evilena; Syon, Danny

2011-12-01

The aim of this research is to highlight the role of ancient parasites as evidence for human migration in past populations. The material analysed was soil sediment from the excavation of a medieval cesspool in the city of Acre, in Israel. Archaeological stratigraphy and radiocarbon dating of a fragment of animal bone from the cesspool confirm its use in the 13th century CE, during the crusader period. At that time Acre was located in the Frankish Kingdom of Jerusalem. Soil samples from the cesspool were analysed and eggs of the roundworm (Ascaris lumbricoides) and fish tapeworm (Diphyllobothrium latum) were identified. The fish tapeworm has only been found in the mainland Near East once before, in a latrine of the crusader Order of St. John (Knights Hospitaller). It has been absent in all earlier cesspools, latrines and coprolites so far studied in the region. In contrast to its rarity in the Levant, the fish tapeworm was common in northern Europe during the medieval period. The presence of fish tapeworm eggs in a crusader period cesspool in Acre suggests its use by crusaders or pilgrims from northern Europe who travelled to the Levant carrying these parasites in their intestines. Copyright © 2011 Elsevier Inc. All rights reserved.

Drug transport mechanism of the AcrB efflux pump.

Science.gov (United States)

Pos, Klaas M

2009-05-01

In Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, tripartite multidrug efflux systems extrude cytotoxic substances from the cell directly into the medium bypassing periplasm and the outer membrane. In E. coli, the tripartite efflux system AcrA/AcrB/TolC is the pump that extrudes multiple antibiotics, dyes, bile salts and detergents. The inner membrane component AcrB, a member of the Resistance Nodulation cell Division (RND) family, is the major site for substrate recognition and energy transduction of the entire tripartite system. The drug/proton antiport processes in this secondary transporter are suggested to be spatially separated, a feature frequently observed for primary transporters like membrane-bound ATPases. The recently elucidated asymmetric structure of the AcrB trimer reveals three different monomer conformations proposed to represent consecutive states in a directional transport cycle. Each monomer shows a distinct tunnel system with entrances located at the boundary of the outer leaflet of the inner membrane and the periplasm through the periplasmic porter (pore) domain towards the funnel of the trimer and TolC. In one monomer a hydrophobic pocket is present which has been shown to bind the AcrB substrates minocyclin and doxorubicin. The energy conversion from the proton motive force into drug efflux includes proton binding in (and release from) the transmembrane part. The conformational changes observed within a triad of essential, titratable residues (D407/D408/K940) residing in the hydrophobic transmembrane domain appear to be transduced by transmembrane helix 8 and associated with the conformational changes seen in the periplasmic domain. From the asymmetric structure a possible peristaltic pump transport mechanism based on a functional rotation of the AcrB trimer has been postulated. The novel drug transport model combines the alternate access pump mechanism with the rotating site catalysis of F(1)F(o) ATPase as

75 FR 4882 - Meeting of the ACRS Subcommittee on EPR; Notice of Meeting

Science.gov (United States)

2010-01-29

... NUCLEAR REGULATORY COMMISSION Advisory Committee On Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on EPR; Notice of Meeting The ACRS U.S. Evolutionary Power Reactor (EPR) Subcommittee will hold a... with Open Items concerning the U.S. EPR Design Certification (DCD) Application and the Calvert Cliffs...

78 FR 11796 - Kentucky Regulatory Program

Science.gov (United States)

2013-02-20

.... --$2,000 per acre and each fraction thereof for operations on previously mined areas. --$3,500 per acre... program (``the Kentucky program'') for surface coal mining and reclamation operations under the Surface... the amount of the performance bond for each surface coal mining and reclamation operation is...

DCS emulator development for the ACR-1000 simulator

International Nuclear Information System (INIS)

Nakashima, Y.; Trueman, R.; Ishii, K.

2010-01-01

Nuclear Power Plant (NPP) simulators are the main means for operator training and as such are a crucial part of the NPP operation life-cycle. Hitachi, Ltd., Information and Control Systems Company (henceforth 'Hitachi') is the preferred DCS and DCS emulator developer and supplier for the ACR-1000 NPP control system. Hitachi's concept for the DCS (distributed control system) portion of the ACR-1000 simulator is 'total emulation of the DCS' by software. This paper will review the current status of the technical development and the major project milestones. (author)

New insights into the structural and functional involvement of the gate loop in AcrB export activity.

Science.gov (United States)

Ababou, Abdessamad

2018-02-01

AcrB is a major multidrug exporter in Escherichia coli and other Gram-negative bacteria. Its gate loop, located between the proximal and the distal pockets, have been reported to play important role in the export of many antibiotics. This loop location, rigidity and interactions with substrates have led recent reports to suggest that AcrB export mechanism operates in a sequential manner. First the substrate binds the proximal pocket in the access monomer, then it moves to bind the distal pocket in the binding monomer and subsequently it is extruded in the extrusion monomer. Recently, we have demonstrated that the gate loop is not required for the binding of Erythromycin but the integrity of this loop is important for an efficient export of this substrate. However, here we show that the antibiotic susceptibilities of the same AcrB gate loop mutants for Doxorubicin were unaffected, suggesting that this loop is not required for its export, and we demonstrate that this substrate may use principally the tunnel-1, located between transmembranes 8 and 9, more often than previously reported. To further explain our findings, here we address the gate loop mutations effects on AcrB solution energetics (fold, stability, molecular dynamics) and on the in vivo efflux of Erythromycin and Doxorubicin. Finally, we discuss the efflux and the discrepancy between the structural and the functional experiments for Erythromycin in these gate loop mutants. Copyright © 2017 Elsevier B.V. All rights reserved.

Natural Areas Analysis and Evaluation: Oak Ridge Reservation

Energy Technology Data Exchange (ETDEWEB)

Baranski, Micahel J [self

2009-11-01

EXECUTIVE SUMMARY The Oak Ridge Reservation, encompassing 33,639 acres in the Valley and Ridge Physiographic Province of East Tennessee, has long been known for its unfragmented forests and high biodiversity. Many areas on the Reservation have been recognized as important natural areas, but no comprehensive treatment has been performed to evaluate the relative significance and importance of these areas compared to each other. The present study was conducted to develop a set of guidelines for evaluating the natural value of specific areas, to evaluate all the terrestrial areas that are currently delineated, and to rank all areas according to their relative biodiversity importance. All available data, reports and site-specific information relevant to Reservation lands, including Tennessee Division of Natural Areas database information, were evaluated and field work was conducted. Methodologies and criteria for assessment and evaluation of areas were developed; categories of criteria were devised; and a ranking system for evaluation of natural areas was produced. There were 70 areas evaluated during the study. The system is flexible, dynamic and easily revised to reflect updated and new information and interpretations. Eight categories of evaluation factors were established and used to characterize each site. These were the following: size of area, number or status taxa present, number of Endangered and Threatened taxa present, rarity of the Endangered and Threatened taxa on the Reservation, community diversity, site integrity and quality, disturbance and threat levels, and other significant features and factors. Each category generally consisted of a 5-point ranking scale from 0-4, allowing for a possible composite score of 32, with higher ranked, more important, sites attaining higher scores. Highly ranked sites are representative of regional natural diversity; contain outstanding natural features, communities or geology and/or very rare taxa or other elements; are

Burnup dependence of coolant void reactivity for ACR-1000 cell

International Nuclear Information System (INIS)

Le Tellier, R.; Marleau, G.; Hebert, A.; Roubstov, D.; Altiparmakov, D.; Irish, D.

2008-01-01

The Advanced Candu Reactor (ACR-1000) is light water cooled, fueled with enriched uranium and has a smaller lattice pitch than the Candu-6. As a result, the neutronic behavior of the ACR-1000 cell is expected to be somewhat different from that of the Candu-6 leading to a negative coolant void reactivity (CVR). Here we evaluate the CVR for the ACR-1000 cell using the lattice code DRAGON and compare our results with those obtained using the code WIMS-AECL. The differences observed between these two codes for the burnup dependence of the CVR is mainly explained in terms of the specific cell leakage model used by both codes. (authors)

78 FR 27284 - Public Transportation on Indian Reservations Program; Tribal Transit Program

Science.gov (United States)

2013-05-09

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Public Transportation on Indian... Federal Register Notice (77 FR 67439) Fiscal Year 2013 Public Transportation on Indian Reservation Program... formula apportionment to eligible Indian tribes providing public transportation on tribal lands. FTA...

Advanced CANDU reactor development: a customer-driven program

International Nuclear Information System (INIS)

Hopwood, J.M.

2005-01-01

The Advanced CANDU Reactor (ACR) product development program is well under way. The development approach for the ACR is to ensure that all activities supporting readiness for the first ACR project are carded out in parallel, as parts of an integrated whole. In this way design engineering, licensing, development and testing, supply chain planning, construct ability and module strategy, and planning for commissioning and operations, all work in synergy with one another. Careful schedule management :ensures that program focus stays on critical path priorities.'This paper provides an overview of the program, with an emphasis on integration to ensure maximum project readiness, This program management approach is important now that AECL is participating as the reactor vendor in Dominion Energy's DOE-sponsored Combined Construction/Operating License (COL) program. Dominion Energy selected the ACR-700 as their reference reactor technology for purposes of demonstrating the COL process. AECL's development of the ACR is unique in that pre-licensing activities are being carded out parallel in the USA and Canada, via independent, but well-communicated programs. In the short term, these programs are major drivers of ACR development. The ACR design approach has been to optimize to achieve major design objectives: capital cost reduction, robust design with ample margins, proveness by using evolutionary change from existing :reference plants, design for ease :of operability. The ACR development program maintains these design objectives for each of the program elements: Design: .Carefully selected design innovations based on the SEU fuel/light water coolant:/heavy water moderator approach. Emphasis on lessons-learned review from operating experience and customer feedback Licensing: .Safety case based on strengths of existing CANDU plus benefits of optimised design Development and Test: Choice of materials, conditions to enable incremental testing building on existing CANDU and LWR

Patient phenotypes in fibromyalgia comorbid with systemic sclerosis or rheumatoid arthritis: influence of diagnostic and screening tests. Screening with the FiRST questionnaire, diagnosis with the ACR 1990 and revised ACR 2010 criteria.

Science.gov (United States)

Perrot, Serge; Peixoto, Mariana; Dieudé, Philippe; Hachulla, Eric; Avouac, Jerome; Ottaviani, Sebastien; Allanore, Yannick

2017-01-01

Fibromyalgia (FM) may occur with rheumatoid arthritis (RA) and systemic sclerosis (SSc), and debate remains about its diagnosis. We aimed to use three FM tools (a screening tool (FiRST), diagnostic criteria (ACR 1990 and revised 2010), to compare FM prevalence between RA and SSc patients, to describe the phenotypes of patients with comorbid FM, and to analyze links between FM and secondary Sjögren's syndrome (SS). Consecutive adult patients with confirmed RA or SSc from four university hospitals were tested with the three FM tools. FiRST detected FM in 22.6% of the 172 RA patients, with confirmation in 22.1% (ACR1990) and 19.1% (ACR2010). ACR1990FM+ RA patients had more diffuse pain, whereas ACR2010FM+ RA patients had higher BMI and pain intensity, more diffuse pain, active disease, disability, and associated SS. FiRST detected FM in 27.8% of the 122 SSc patients, with confirmation in 30.3% (ACR1990) and 23.7% (ACR2010). ACR1990FM+ SSc patients had greater disability and pain intensity, and more diffuse pain, whereas ACR2010FM+ SSc patients had higher BMI, pain intensity, more disability and diffuse pain, and associated SS. Correlations between FM diagnostic and screening tool results were modest in both conditions. Secondary SS was associated with comorbid FM. The prevalence of FM is high in SSc and RA, whatever the FM diagnostic tool used. Secondary SS is associated with FM in both RA and SSc. The revised ACR 2010 FM criteria and FiRST screening tool reveal specific phenotypes potentially useful for improving disease management.

Assessment, Cleanup and Redevelopment Exchange System (ACRES)

Data.gov (United States)

U.S. Environmental Protection Agency — The Assessment, Cleanup and Redevelopment Exchange System (ACRES) is an online database for Brownfields Grantees to electronically submit data directly to EPA.

Usefulness of ACR MRI phantom for quality assurance of MRI instruments

International Nuclear Information System (INIS)

Lee, Jung Whee; Ahn, Kook Jin; Lee, Seung Koo; Na, Dong Gyu; Oh, Chang Hyun; Chang, Yong Min; Lim, Tae Hwan

2006-01-01

To examine whether the ACR phantom could be used in quality standards for magnetic resonance imaging (MRI) instruments in Korea. We conducted the phantom test using the ACR MRI phantom in 20 MRI instruments currently used in Korea. According to ACR criteria, we acquired the phantom images which were then assessed by the following seven tests: geometric accuracy, high spatial resolution, slice thickness accuracy, slice position accuracy, image intensity uniformity, percent signal ghosting, and low contrast object detectability. The phantom images were interpreted by three experienced radiologists according to ACR criteria. Then, we examined the failure rate of each test and evaluated the inter-observer variation in the measurements and test failure. The failure rate of each test could be broken into the following components: geometric accuracy (11-21%), high contrast spatial resolution (10-15%), slice thickness accuracy(6-22%), slice position accuracy (5-17%), image intensity uniformity (6%), percent signal ghosting (16%), and low contrast object detectability (8-10%). In this series, all the failure rates were less than 30%. In addition, no inter-observer variation was seen in the measurements and test failure. ACR MRI phantom promises to be established as the standard phantom for MRI instruments in Korea because of its objectivity in assessing the phantom images

78 FR 48035 - Conservation Reserve Program, Re-Enrollment

Science.gov (United States)

2013-08-07

... longstanding USDA policy and existing handbooks. This technical amendment did not require Office of Management... Reserve Program (CRP) regulations to clarify that land with use restrictions that prohibit the production... other deed restrictions that restrict the production of agricultural commodities. A 2003 interim rule...

ACR Appropriateness Criteria on Resectable Rectal Cancer

International Nuclear Information System (INIS)

Suh, W. Warren; Blackstock, A. William; Herman, Joseph; Konski, Andre A.; Mohiuddin, Mohammed; Poggi, Matthew M.; Regine, William F.; Cosman, Bard C.; Saltz, Leonard; Johnstone, Peter A.S.

2008-01-01

The American College of Radiology (ACR) Appropriateness Criteria on Resectable Rectal Cancer was updated by the Expert Panel on Radiation Oncology-Rectal/Anal Cancer, based on a literature review completed in 2007

Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria.

NARCIS (Netherlands)

Britsemmer, K.; Ursum, J.; Gerritsen, M.; Tuyl, L. van; Schaardenburg, D. van

2011-01-01

Abstract: Background Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA). Objective:To evaluate the diagnostic and discriminative ability of these new criteria compared with

76 FR 7883 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Power...

Science.gov (United States)

2011-02-11

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... will review the staff's evaluation of the Point Beach Units 1 and 2 Extended Power Uprate application... can be made. Thirty five hard copies of each presentation or handout should be provided to the...

Endangered Species Program Naval Petroleum Reserves in California

International Nuclear Information System (INIS)

1992-03-01

The Naval Petroleum Reserves in California (NPRC) are operated by the US Department of Energy (DOE) and Chevron USA. (CUSA). Four federally-listed endangered animal species and one threatened plant species are known to occur on NPRC: the San Joaquin kit fox (Vulpes macrotis mutica), blunt-nosed leopard lizard (Gambelia), giant kangaroo rat (Dipodomys ingens), Tipton kangaroo rat (Dipodomys nitratoides nitratoides) and Hoover's Wooly-star (Eriastrum hooveri). All five are protected under the Endangered Species Act of 1973 (as amended) (Public Law 93-205), which declares that it is the policy of Congress that all Federal departments and agencies shall seek to conserve endangered and threatened species and shall utilize their authorities in furtherance of the purposes of the Act. DOE is also obliged to determine whether actions taken by their lessees on Naval Petroleum Reserve No. 2 (NPR-2) will have any effects on endangered species or their habitats. The major objective of the Endangered Species Program on NPR-1 and NPR-2 is to provide DOE with the scientific expertise and continuity of programs necessary for the continued compliance with the Endangered Species Act. The specific objective of this report is to summarize progress and results of the Endangered Species Program made during Fiscal Year 1991 (FY91)

Validation of MCNP and WIMS-AECL/DRAGON/RFSP for ACR-1000 applications

International Nuclear Information System (INIS)

Bromley, Blair P.; Adams, Fred P.; Zeller, Michael B.; Watts, David G.; Shukhman, Boris V.; Pencer, Jeremy

2008-01-01

This paper gives a summary of the validation of the reactor physics codes WIMS-AECL, DRAGON, RFSP and MCNP5, which are being used in the design, operation, and safety analysis of the ACR-1000 R . The standards and guidelines being followed for code validation of the suite are established in CSA Standard N286.7-99 and ANS Standard ANS-19.3-2005. These codes are being validated for the calculation of key output parameters associated with various reactor physics phenomena of importance during normal operations and postulated accident conditions in an ACR-1000 reactor. Experimental data from a variety of sources are being used for validation. The bulk of the validation data is from critical experiments in the ZED-2 research reactor with ACR-type lattices. To supplement and complement ZED-2 data, qualified and applicable data are being taken from other power and research reactors, such as existing CANDU R units, FUGEN, NRU and SPERT research reactors, and the DCA critical facility. MCNP simulations of the ACR-1000 are also being used for validating WIMS-AECL/ DRAGON/RFSP, which involves extending the validation results for MCNP through the assistance of TSUNAMI analyses. Code validation against commissioning data in the first-build ACR-1000 will be confirmatory. The code validation is establishing the biases and uncertainties in the calculations of the WIMS-AECL/DRAGON/RFSP suite for the evaluation of various key parameters of importance in the reactor physics analysis of the ACR-1000. (authors)

Clinical Image Evaluation of Film Mammograms in Korea: Comparison with the ACR Standard

International Nuclear Information System (INIS)

Gwak, Yeon Joo; Kim, Hye Jung; Kwak, Jin Young; Son, Eun Ju; Ko, Kyung Hee; Lee, Jin Hwa; Lim, Hyo Soon; Lee, You Jin; Park, Ji Won; Shin, Kyung Min; Jang, Yun-Jin

2013-01-01

The goal of this study is to compare the overall quality of film mammograms taken according to the Korean standards with the American College of Radiology (ACR) standard for clinical image evaluation and to identify means of improving mammography quality in Korea. Four hundred and sixty eight sets of film mammograms were evaluated with respect to the Korean and ACR standards for clinical image evaluation. The pass and failure rates of mammograms were compared by medical facility types. Average scores in each category of the two standards were evaluated. Receiver operating characteristic curve analysis was used to identify an optimal Korean standard pass mark by taking the ACR standard as the reference standard. 93.6% (438/468) of mammograms passed the Korean standard, whereas only 80.1% (375/468) passed the ACR standard (p < 0.001). Non-radiologic private clinics had the lowest pass rate (88.1%: Korean standard, 71.8%: ACR standard) and the lowest total score (76.0) by the Korean standard. Average scores of positioning were lowest (19.3/29 by the Korean standard and 3.7/5 by the ACR standard). A cutoff score of 77.0 for the Korean standard was found to correspond to a pass level when the ACR standard was applied. We suggest that tighter regulations, such as, raising the Korean pass mark, subtracting more for severe deficiencies, or considering a very low scores in even a single category as failure, are needed to improve the quality of mammography in Korea

77 FR 4585 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Power Uprates...

Science.gov (United States)

2012-01-30

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... Turkey Point, Units 3 and 4, extended power uprate application. The Subcommittee will hear presentations... possible, so that appropriate arrangements can be made. Thirty-five hard copies of each presentation or...

Diversidade genética de populações de andiroba no Baixo Acre Genetic diversity structure of crabwood in Baixo Acre, Brazil

Directory of Open Access Journals (Sweden)

Andréa Raposo

2007-09-01

Full Text Available O objetivo deste trabalho foi avaliar a diversidade genética em duas populações de Carapa guianensis Aubl. (andiroba, no Estado do Acre, e comparar os parâmetros de diversidade com os observados em outras populações da espécie (no Brasil: Flona Tapajós, PA, Porto Acre, AC; e na Costa Rica. Foram avaliados 77 indivíduos adultos com sete locos polimórficos de microssatélites. Observaram-se 51 alelos nas duas populações, em que o número efetivo de alelos por loco (Âe = 3,2 foi inferior ao número médio de alelos por loco (Â = 7,3, o que indica elevado número de alelos com baixa freqüência. Os valores estimados de f não diferiram de zero, o que mostra que não ocorre endogamia nas populações. A taxa de cruzamento aparente foi alta (t a = 1,11 na população Porto Acre, e t a= 0,88 na de Rio Branco, resultado indicador de que a espécie se reproduz por alogamia. Foi observado, por meio das estimativas de Â, He (diversidade gênica e Ne (número efetivo populacional que as populações de andiroba, comparadas neste trabalho, tiveram padrões de diversidade semelhantes, porém, proporções de alelos raros diferentes.The objective of this work was to evaluate the genetic diversity of two Carapa guianensis Aubl. (crabwood populations, in the State of Acre, Brazil, and to compare the diversity estimations with those obtained in other populations of the species (in Brazil: Flona Tapajós, PA, Porto Acre, AC; and in Costa Rica. Seventy-seven individuals were assessed using seven polymorphic microsatellite loci. Fifty-one alleles were observed in the two populations, in which the effective number of alleles per locus (Âe = 3.2 was lower than the average number of alleles per locus (Â = 7.3, which indicates a high number of low frequency alleles. The estimated f values did not differ from zero, showing that inbreeding does not occur in these populations. The apparent outcrossing rate was high for both populations (t a = 1.11 in

Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter.

Science.gov (United States)

Cha, Hi-jea; Müller, Reinke T; Pos, Klaas M

2014-08-01

Multidrug efflux transporters recognize a variety of structurally unrelated compounds for which the molecular basis is poorly understood. For the resistance nodulation and cell division (RND) inner membrane component AcrB of the AcrAB-TolC multidrug efflux system from Escherichia coli, drug binding occurs at the access and deep binding pockets. These two binding areas are separated by an 11-amino-acid-residue-containing switch loop whose conformational flexibility is speculated to be essential for drug binding and transport. A G616N substitution in the switch loop has a distinct and local effect on the orientation of the loop and on the ability to transport larger drugs. Here, we report a distinct phenotypical pattern of drug recognition and transport for the G616N variant, indicating that drug substrates with minimal projection areas of >70 Å(2) are less well transported than other substrates. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Technical quality assessment of breast ultrasound according to American College of Radiology (ACR) Standards

International Nuclear Information System (INIS)

Ko, Kyung Hee; Kim, Eun Kyung; Kim, Young Ah; Son, Eun Ju; Oh, Ki Keun; Chung, Sun Yang

2003-01-01

To evaluate the technical quality of breast ultrasound based on American College of Radiology(ACR) standards. Between March 2002 and July 2002, ninety three breast sonograms obtained from 73 institutions were evaluated based on ACR standards for the hardware, technical settings, labeling of the images and identification. Of 93 breast sonograms, a satisfactory compliance with all ACR standards in the performance of breast US examinations was documented in 31% while the remaining 69% did not fully meet all ACR standards. 4.3% of breast US examinations were performed with a convex transducers, and the focal zone was inappropriately positioned in 14.2%. Gray-scale gain was subjectively characterized as inappropriate in 26.9%, and the size of lesion was not measured in 7.5%. Anatomic location of lesions was inappropriately described in 9.3%. The orientation of an US transducer was not properly labeled on any images in 33.3%. Inadequate recording of patient's information was noted in 43.3%. 50% of sonograms at University medical centers and larger general hospitals fully met all ACR standards while 36.8% at radiologic clinics and 12.1% at other private clinics met all ACR standards. Overall, 69% of breast sonograms failed to meet the quality criteria of the ACR standards. Therefore, it is essential to educate the basic technical details in performing breast US for the quality control.

pH-induced conformational changes of AcrA, the membrane fusion protein of Escherichia coli multidrug efflux system.

Science.gov (United States)

Ip, Hermia; Stratton, Kelly; Zgurskaya, Helen; Liu, Jun

2003-12-12

The multidrug efflux system AcrA-AcrB-TolC of Escherichia coli expels a wide range of drugs directly into the external medium from the bacterial cell. The mechanism of the efflux process is not fully understood. Of an elongated shape, AcrA is thought to span the periplasmic space coordinating the concerted operation of the inner and outer membrane proteins AcrB and TolC. In this study, we used site-directed spin labeling (SDSL) EPR (electron paramagnetic resonance) spectroscopy to investigate the molecular conformations of AcrA in solution. Ten AcrA mutants, each with an alanine to cysteine substitution, were engineered, purified, and labeled with a nitroxide spin label. EPR analysis of spin-labeled AcrA variants indicates that the side chain mobilities are consistent with the predicted secondary structure of AcrA. We further demonstrated that acidic pH induces oligomerization and conformational change of AcrA, and that the structural changes are reversible. These results suggest that the mechanism of action of AcrA in drug efflux is similar to the viral membrane fusion proteins, and that AcrA actively mediates the efflux of substrates.

77 FR 28637 - Advisory Committee On Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Power Uprates...

Science.gov (United States)

2012-05-15

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on...) associated with the Grand Gulf Nuclear Station Unit 1 extended power uprate application. The Subcommittee... made. Thirty-five hard copies of each presentation or handout should be provided to the DFO thirty...

76 FR 32240 - Advisory Committee on Reactor Safeguards (ACRS) Meeting on the ACRS Subcommittee on Power Uprates

Science.gov (United States)

2011-06-03

... Subcommittee on Power Uprates Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... Expanded Operating Domains-Power Distribution Validation and Pin-by-Pin Gamma Scan). The Subcommittee will... hard copies of each presentation or handout should be provided to the DFO thirty minutes before the...

78 FR 70596 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Power Uprates...

Science.gov (United States)

2013-11-26

... Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... hold discussions with the licensee, (Northern States Power Company of Minnesota), the NRC staff, and... made. Thirty-five hard copies of each presentation or handout should be provided to the DFO thirty...

Coarse-grained Simulations of Substrate Export through Multidrug Efflux Transporter AcrB

Science.gov (United States)

Jewel, Yead; Dutta, Prashanta; Liu, Jin

2017-11-01

The treatment of bacterial infectious diseases hampered by the overexpression of multidrug resistance (MDR) systems. The MDR system actively pumps the antibiotic drugs as well as other toxic compounds out of the cells. During the pumping, AcrB (one of the key MDR components) undergoes a series of large-scale proton/substrate dependent conformational changes. In this work, we implement a hybrid coarse-grained PACE force field that couples the united-atom protein model with the coarse-grained MARTINI water/lipid, to investigate the conformational changes of AcrB. We first develop the substrate force field which is compatible with PACE, then we implement the force field to explore large scale structural changes of AcrB in microsecond simulations. The effects of the substrate and the protonation states of two key residues: Asp407 and Asp408, are investigated. Our results show that the drug export through AcrB is proton as well as substrate dependent. Our simulations explain molecular mechanisms of substrate transport through AcrB complex, as well as provide valuable insights for designing proper antibiotic drugs. Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R01GM122081.

ACR-SNM Task Force on Nuclear Medicine Training: report of the task force.

Science.gov (United States)

Guiberteau, Milton J; Graham, Michael M

2011-06-01

The expansion of knowledge and technological advances in nuclear medicine and radiology require physicians to have more expertise in functional and anatomic imaging. The convergence of these two specialties into the new discipline of molecular imaging has also begun to place demands on residency training programs for additional instruction in physiology and molecular biology. These changes have unmasked weaknesses in current nuclear medicine and radiology training programs. Adding to the impetus for change are the attendant realities of the job market and uncertain employment prospects for physicians trained in nuclear medicine but not also trained in diagnostic radiology. With this background, the ACR and the Society of Nuclear Medicine convened the Task Force on Nuclear Medicine Training to define the issues and develop recommendations for resident training.

Conservation reserve program: benefit for grassland birds in the northern plains

Science.gov (United States)

Reynolds, R.E.; Shaffer, T.L.; Sauer, J.R.; Peterjohn, B.G.

1994-01-01

During the past few decades numbers of some species of upland-nesting birds in North America have declined. Duck species such as mallard (Anas platyrhynchos), northern pintail (A. acuta) and blue-winged teal (A. discors) have declined since the early 1970s and have remained low since 1985 (Caithamer et al. 1993). Some grassland-dependent nonwaterfowl species also have declined since 1966, as indicated by the North American Breeding Bird Survey (BBS) (Robbins et al. 1986). For prairie-nesting ducks, population declines can be attributed mostly to low recruitment, partially as a result of low nest success. Klett et al. (1988) concluded that nest success (probability of ≥1 egg of clutch hatches) in much of the U.S. Prairie Pothole Region was inadequate to maintain populations of the five most common upland-nesting duck species studied, and that predators were the most important cause of nest failure. Over the years, as grassland areas have been converted to cropland, ducks have concentrated their nesting in the remaining areas of available habitat, where predators such as red fox (Vulpes vulpes), striped skunk (Mephitis mephitis) and badger (Taxidea taxus) forage (Cowardin et al. 1983). The reasons for declining populations of grassland nonwaterfowl birds are not clear but the loss of suitable grassland-nesting habitat probably is an important factor. Currently, approximately 95 percent of the land in North Dakota is used for agricultural purposes, of which over 60 percent is used for annual crop production (Haugse 1990). Of the grassland that remains, 95 percent is used for livestock production. This probably had a severe impact on grassland bird species that seek idle grass cover for nesting. The 1985 and 1990 U.S. Farm Bills include provisions under the Food Security Act to fund a cropland-idling program called the Conservation Reserve Program (CRP). Over 36 million acres have been enrolled nationwide in the CRP since 1985 (Osborn 1993), and up to 25 percent of

Development of a platform for interactive training ACRs; Desarrollo de una plataforma interactiva para formacion en ACRs

Energy Technology Data Exchange (ETDEWEB)

Gonzalvo, A.; Martin, J. E.; Herrera, J. A.

2013-07-01

Due to the workload of plant personnel and extension courses, you can use other methods of online learning to complement the methods of classroom learning, so that it minimizes disruption to the day job plant day. GNFE is implementing systems on-line training in ACRs based on MOODLE which has many advantages.

The Physics Entrepreneurship Program at Case Western Reserve University

Science.gov (United States)

Taylor, Cyrus

2001-10-01

The Physics Entrepreneurship Program is a new, two-year Master's Program designed to empower physicists as entrepreneurs. Launched by the Dept. of Physics at Case Western Reserve University in close cooperation with the Weatherhead School of Management, the program is now in its second year. This innovative new program has already attracted important attention from the business community, including seed funding of a student launched venture, international press coverage, including an article in Business Week, and government interest, including an invitation to brief the Advisory Board of the Mathematical and Physical Sciences Division of the National Science Foundation. This talk will discuss the structure and content of the program, the lessons we are learning, and early indicators of success including a student-launched new business venture that has already secured more than $ 250,000 in seed funding.

76 FR 44964 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on U.S...

Science.gov (United States)

2011-07-27

... Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on August 18, 2011, Room T-2B3, 11545 Rockville Pike... the meeting, if possible, so that appropriate arrangements can be made. Thirty-five hard copies of...

78 FR 8202 - Meeting of the Joint ACRS Subcommittees on Thermal Hydraulic Phenomena and Materials, Metallurgy...

Science.gov (United States)

2013-02-05

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the Joint ACRS Subcommittees on Thermal Hydraulic Phenomena and Materials, Metallurgy and Reactor Fuels; Notice of Meeting The Joint ACRS Subcommittees on Thermal Hydraulic Phenomena and Materials, Metallurgy and...

Demystifying "oxi" cocaine: Chemical profiling analysis of a "new Brazilian drug" from Acre State.

Science.gov (United States)

da Silva Junior, Ronaldo C; Gomes, Cezar S; Goulart Júnior, Saulo S; Almeida, Fernanda V; Grobério, Tatiane S; Braga, Jez W B; Zacca, Jorge J; Vieira, Maurício L; Botelho, Elvio D; Maldaner, Adriano O

2012-09-10

Recent information from various sources suggests that a new illicit drug, called "oxi", is being spread across Brazil. It would be used in the smoked form and it would look like to crack cocaine: usually small yellowish or light brown stones. As fully released in the media, "oxi" would differ from crack cocaine in the sense that crack would contain carbonate or bicarbonate salts whereas "oxi" would include the addition of calcium oxide and kerosene (or gasoline). In this context, this work presents a chemical profiling comparative study between "oxi" street samples seized by the Civil Police of the State of Acre (CP/AC) and samples associated with both international and interstate drug trafficking seized by the Brazilian Federal Police in Acre (FP/AC). The outcome of this work assisted Brazilian authorities to stop inaccurate and alarmist releases on this issue. It may be of good use by the forensic community in order to better understand matters in their efforts to guide local law enforcement agencies in case such claims reach the international illicit market. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate.

Directory of Open Access Journals (Sweden)

Abdessamad Ababou

Full Text Available Gram-negative bacteria such as E. coli use tripartite efflux pumps such as AcrAB-TolC to expel antibiotics and noxious compounds. A key feature of the inner membrane transporter component, AcrB, is a short stretch of residues known as the gate/switch loop that divides the proximal and distal substrate binding pockets. Amino acid substitutions of the gate loop are known to decrease antibiotic resistance conferred by AcrB. Here we present two new AcrB gate loop variants, the first stripped of its bulky side chains, and a second in which the gate loop is removed entirely. By determining the crystal structures of the variant AcrB proteins in the presence and absence of erythromycin and assessing their ability to confer erythromycin tolerance, we demonstrate that the gate loop is important for AcrB export activity but is not required for erythromycin binding.

Portrait of leptospirosis in the State of Acre, Brazil

Directory of Open Access Journals (Sweden)

Eloizy Mariana Dias de Medeiros Cirilo Costa

2017-03-01

Full Text Available Introduction: Leptospirosis is an acute bacterial disease, that has global distribution and manifests itself in subclinical or asymptomatic way, having mild or severe conditions that can lead to the death of the patient. Objective: To identify, among the municipalities of the state of Acre, Brazil, those with the highest incidence of leptospirosis between 2010 and 2015, and in addition, to determine the prevalence of this disease between the sexes. Methods: Descriptive study, of documentary character, with epidemiological base and quantitative approach. It was made by available documents through the Department of Informatics of the Unified Health System of Brazil (DATASUS and also by the Health Secretary of State of Acre (SESACRE. Variables were selected as sex, age and year of notification. Regarding the analysis, it is emphasized that it was quantitative and descriptive and the results were presented in tables built in Microsoft Word. Results: It was found that the capital of the state of Acre, Rio Branco, led every year, contributing to the higher proportion of notifications related to leptospirosis. Regarding gender, there was a predilection for males and among age groups, the period of 20 to 39 years contributes to the greater number of cases of the disease. Conclusion: Leptospirosis is a worldwide public health problem and in the state of Acre, the high rainfall, the agglomeration of low income combined with inadequate sanitation, collaborate to infestation of transmitters animals, providing high rates of the disease. Thus, it appears that these high numbers can probably be attributed to the ineffectiveness of preventive activities, as well as insufficient investment directed to social policies and infrastructure sectors. Keywords: Infectious Disease. Leptospirosis. Prevalence. Incidence.

ACR Appropriateness Criteria® Tinnitus.

Science.gov (United States)

Kessler, Marcus M; Moussa, Marwan; Bykowski, Julie; Kirsch, Claudia F E; Aulino, Joseph M; Berger, Kevin L; Choudhri, Asim F; Fife, Terry D; Germano, Isabelle M; Kendi, A Tuba; Kim, Jeffrey H; Luttrull, Michael D; Nunez, Diego; Shah, Lubdha M; Sharma, Aseem; Shetty, Vilaas S; Symko, Sophia C; Cornelius, Rebecca S

2017-11-01

Tinnitus is the perception of sound in the absence of an external source. It is a common symptom that can be related to hearing loss and other benign causes. However, tinnitus may be disabling and can be the only symptom in a patient with a central nervous system process disorder. History and physical examination are crucial first steps to determine the need for imaging. CT and MRI are useful in the setting of pulsatile tinnitus to evaluate for an underlying vascular anomaly or abnormality. If there is concomitant asymmetric hearing loss, neurologic deficit, or head trauma, imaging should be guided by those respective ACR Appropriateness Criteria ® documents, rather than the presence of tinnitus. Imaging is not usually appropriate in the evaluation of subjective, nonpulsatile tinnitus that does not localize to one ear. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Computer code qualification program for the Advanced CANDU Reactor

International Nuclear Information System (INIS)

Popov, N.K.; Wren, D.J.; Snell, V.G.; White, A.J.; Boczar, P.G.

2003-01-01

Atomic Energy of Canada Ltd (AECL) has developed and implemented a Software Quality Assurance program (SQA) to ensure that its analytical, scientific and design computer codes meet the required standards for software used in safety analyses. This paper provides an overview of the computer programs used in Advanced CANDU Reactor (ACR) safety analysis, and assessment of their applicability in the safety analyses of the ACR design. An outline of the incremental validation program, and an overview of the experimental program in support of the code validation are also presented. An outline of the SQA program used to qualify these computer codes is also briefly presented. To provide context to the differences in the SQA with respect to current CANDUs, the paper also provides an overview of the ACR design features that have an impact on the computer code qualification. (author)

The application of ZED-2 data in the design and analysis of the ACR-1000

International Nuclear Information System (INIS)

Dweiri, Y.

2011-01-01

The presentation discusses how data obtained from experiments performed in the ZED-2 Critical Facility at Atomic Energy of Canada Limited's Chalk River Laboratories is used in the design and analysis of the ACR-1000. The ACR-1000 design is an evolutionary advancement of the well-established CANDU Reactor technology to Generation 3+. When key core physics parameters for the ACR-1000 are calculated, biases and uncertainties in using the reactor physics toolset WIMS AECL/DRAGON/RFSP and MCNP must be quantified to be able to appropriately assess safety margins in the design. A unique feature of ZED-2 is the ability to perform a wide variety of experiments which is important in providing data that is used in the design and analysis of the ACR-1000. The ACR-1000 was designed to have a small and slightly negative coolant-void-reactivity (CVR), which provides an inherent safety characteristic to mitigate the reactivity transient under any postulated loss-of-coolant accident (LOCA) scenarios. The bias and uncertainty for CVR (full and checkerboard) calculations, derived through comparisons with experimental data, is pivotal to assess the accuracy of the predicted CVR value. This bias and uncertainty is also used in important LOCA analysis to demonstrate the safety features of the ACR-1000. This crucial physics information is available through experiments performed in ZED-2. Other important data that is obtained from ZED-2 in assessing core design pertains to end-flux peaking and in-core flux detector response. The end-region configuration of ACR fuel bundles is an important component of the design, as the axial power distribution within the bundle is not uniform. Detector response in an ACR flux spectrum is important to determine the suitability of safety system detectors when used in the ACR-1000 core. These applications demonstrate the versatility of ZED-2 in providing important reactor physics data makes this critical facility indispensible in current and future R and D

Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance.

Science.gov (United States)

Wang, Yinhu; Mowla, Rumana; Guo, Liwei; Ogunniyi, Abiodun D; Rahman, Taufiq; De Barros Lopes, Miguel A; Ma, Shutao; Venter, Henrietta

2017-02-15

Drug efflux pumps confer multidrug resistance to dangerous pathogens which makes these pumps important drug targets. We have synthesised a novel series of compounds based on a 2-naphthamide pharmacore aimed at inhibiting the efflux pumps from Gram-negative bacteria. The archeatypical transporter AcrB from Escherichia coli was used as model efflux pump as AcrB is widely conserved throughout Gram-negative organisms. The compounds were tested for their antibacterial action, ability to potentiate the action of antibiotics and for their ability to inhibit Nile Red efflux by AcrB. None of the compounds were antimicrobial against E. coli wild type cells. Most of the compounds were able to inhibit Nile Red efflux indicating that they are substrates of the AcrB efflux pump. Three compounds were able to synergise with antibiotics and reverse resistance in the resistant phenotype. Compound A3, 4-(isopentyloxy)-2-naphthamide, reduced the MICs of erythromycin and chloramphenicol to the MIC levels of the drug sensitive strain that lacks an efflux pump. A3 had no effect on the MIC of the non-substrate rifampicin indicating that this compound acts specifically through the AcrB efflux pump. A3 also does not act through non-specific mechanisms such as outer membrane or inner membrane permeabilisation and is not cytotoxic against mammalian cell lines. Therefore, we have designed and synthesised a novel chemical compound with great potential to further optimisation as inhibitor of drug efflux pumps. Copyright © 2017 Elsevier Ltd. All rights reserved.

Using the ACR/NEMA standard with TCP/IP and Ethernet

Science.gov (United States)

Chimiak, William J.; Williams, Rodney C.

1991-07-01

There is a need for a consolidated picture archival and communications system (PACS) in hospitals. At the Bowman Gray School of Medicine of Wake Forest University (BGSM), the authors are enhancing the ACR/NEMA Version 2 protocol using UNIX sockets and TCP/IP to greatly improve connectivity. Initially, nuclear medicine studies using gamma cameras are to be sent to PACS. The ACR/NEMA Version 2 protocol provides the functionality of the upper three layers of the open system interconnection (OSI) model in this implementation. The images, imaging equipment information, and patient information are then sent in ACR/NEMA format to a software socket. From there it is handed to the TCP/IP protocol, which provides the transport and network service. TCP/IP, in turn, uses the services of IEEE 802.3 (Ethernet) to complete the connectivity. The advantage of this implementation is threefold: (1) Only one I/O port is consumed by numerous nuclear medicine cameras, instead of a physical port for each camera. (2) Standard protocols are used which maximize interoperability with ACR/NEMA compliant PACSs. (3) The use of sockets allows a migration path to the transport and networking services of OSIs TP4 and connectionless network service as well as the high-performance protocol being considered by the American National Standards Institute (ANSI) and the International Standards Organization (ISO) -- the Xpress Transfer Protocol (XTP). The use of sockets also gives access to ANSI's Fiber Distributed Data Interface (FDDI) as well as other high-speed network standards.

Breast Cancer Screening for Average-Risk Women: Recommendations From the ACR Commission on Breast Imaging.

Science.gov (United States)

Monticciolo, Debra L; Newell, Mary S; Hendrick, R Edward; Helvie, Mark A; Moy, Linda; Monsees, Barbara; Kopans, Daniel B; Eby, Peter R; Sickles, Edward A

2017-09-01

Breast cancer is the most common non-skin cancer and the second leading cause of cancer death for women in the United States. Before the introduction of widespread mammographic screening in the mid-1980s, the death rate from breast cancer in the US had remained unchanged for more than 4 decades. Since 1990, the death rate has declined by at least 38%. Much of this change is attributed to early detection with mammography. ACR breast cancer screening experts have reviewed data from RCTs, observational studies, US screening data, and other peer-reviewed literature to update our recommendations. Mammography screening has consistently been shown to significantly reduce breast cancer mortality over a variety of study designs. The ACR recommends annual mammography screening starting at age 40 for women of average risk of developing breast cancer. Our recommendation is based on maximizing proven benefits, which include a substantial reduction in breast cancer mortality afforded by regular screening and improved treatment options for those diagnosed with breast cancer. The risks associated with mammography screening are also considered to assist women in making an informed choice. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Breast imaging and reporting data system - Mammography. ACR BI-RADS registered -Mammography

International Nuclear Information System (INIS)

Fischer, U.; Helbrich, T.

2006-01-01

ACR BI-RADS registered mammography is an established technique in all German-speaking countries and has become a standard part of all mammographic findings. The first German-language edition three years ago made a significant contribution to this. This is the second, revised and edited edition. It is based on the fourth English-language edition of the ACR which was published in 2003. (orig.)

The ACR: Advanced design features for a short construction schedule

International Nuclear Information System (INIS)

Elgohary, M.; Fairclough, N.

2003-01-01

Building on the successful CANDU construction at Qinshan, the ACR-700 is designed with constructability considerations as a major requirement during all project phases from the concept design stage to the detail design stage. A project schedule of 48 months has been developed for the nth ACR unit with a 36 months construction period from First Concrete to Fuel Load. This paper describes some of the advanced design features implemented in the reactor building design in order to achieve this short construction period. These features include large volume concrete pours, prefabricated rebar, composite structures, prefabricated permanent formwork and significant modularization and prefabrication

76 FR 26775 - Advisory Committee on Reactor Safeguards Meeting of the ACRS Subcommittee on EPR; Cancellation to...

Science.gov (United States)

2011-05-09

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards Meeting of the ACRS Subcommittee on EPR; Cancellation to May 11, 2011, ACRS Meeting-- Federal Register Notice The Federal Register Notice for the ACRS Subcommittee Meeting on the design certification application review of the U.S...

Conservation Reserve Program effects on floodplain land cover management.

Science.gov (United States)

Jobe, Addison; Kalra, Ajay; Ibendahl, Elise

2018-05-15

Growing populations and industrialized agriculture practices have eradicated much of the United States wetlands along river floodplains. One program available for the restoration of floodplains is the Conservation Reserve Program (CRP). The current research explores the effects CRP land change has on flooding zones, utilizing Flood Modeller and HEC-RAS. Flood Modeller is proven a viable tool for flood modeling within the United States when compared to HEC-RAS. Application of the software is used in the Nodaway River system located in the western halves of Iowa and Missouri to model effects of introducing new forest areas within the region. Flood stage during the conversion first decreases in the early years, before rising to produce greater heights. Flow velocities where CRP land is present are reduced for long-term scopes. Velocity reduction occurs as the Manning's roughness increases due to tree diameter and brush density. Flood zones become more widespread with the implementation of CRP. Future model implementations are recommended to witness the effects of smaller flood recurrence intervals. Copyright © 2018 Elsevier Ltd. All rights reserved.

Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

Directory of Open Access Journals (Sweden)

Xuan Wang-Kan

2017-07-01

Full Text Available AcrAB-TolC is the paradigm resistance-nodulation-division (RND multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex. We constructed a nonfunctional AcrB mutant by replacing D408, a highly conserved residue essential for proton translocation. Western blotting confirmed that the AcrB D408A mutant had the same native level of expression of AcrB as the parental strain. The mutant had no growth deficiencies in rich or minimal medium. However, compared with wild-type SL1344, the mutant had increased accumulation of Hoechst 33342 dye and decreased efflux of ethidium bromide and was multidrug hypersusceptible. The D408A mutant was attenuated in vivo in mouse and Galleria mellonella models and showed significantly reduced invasion into intestinal epithelial cells and macrophages in vitro. A dose-dependent inhibition of invasion was also observed when two different efflux pump inhibitors were added to the wild-type strain during infection of epithelial cells. RNA sequencing (RNA-seq revealed downregulation of bacterial factors necessary for infection, including those in the Salmonella pathogenicity islands 1, 2, and 4; quorum sensing genes; and phoPQ. Several general stress response genes were upregulated, probably due to retention of noxious molecules inside the bacterium. Unlike loss of AcrB protein, loss of efflux function did not induce overexpression of other RND efflux pumps. Our data suggest that gene deletion mutants are unsuitable for studying membrane transporters and, importantly, that inhibitors of AcrB efflux function will not induce expression of other RND pumps.

Uranium exploration, mining and milling proposal, Navajo Indian Reservation, New Mexico

International Nuclear Information System (INIS)

Babby, W.D.

1974-01-01

The Secretary of the Interior has been requested to approve an exploration permit and mining lease which are part of a uranium exploration, mining, and milling Agreement, negotiated between the Navajo Tribe and the Exxon Corporation. The exploration area is a 400,000 acre tract located on the Navajo Reservation in San Juan County, New Mexico. If uranium ore in sufficient quantities to warrant development is discovered, Exxon is authorized to take a total of 51,200 acres to lease for mining, of which only 5,120 surface acres may be used for mining and milling purposes. While all exploration and predevelopment costs prior to mining must be borne by Exxon, the Navajo Tribe has reserved the right to participate in the venture on either a royalty basis or as a partner holding up to a 40 percent working interest. Impacts resulting from exploration will include disturbance of soils and vegetation and air quality degradation resulting from the vehicular movement and the operation of drilling equipment. If mining and milling takes place significant environmental impacts include: sub-surface water depletion, soils and vegetation disturbance, air quality degradation, interruption of the wildlife habitat, population increases, increased demands on community services and facilities, and disruption of established lifestyles and social patterns. Low levels of radioactive emissions will be found at mine and mill sites. Income and employment opportunities from the project to the Navajo Tribe, Navajo people, and the entire San Juan County community will be significant

40 CFR 73.85 - Administrator review of the reserve program.

Science.gov (United States)

2010-07-01

... PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Energy Conservation and Renewable Energy Reserve § 73... (ii) Qualified renewable energy generation, allocations of allowances will continue pursuant to § 73... allocated for either qualified energy conservation measures or qualified renewable energy generation, the...

Sensitivity of Escherichia coli acrA Mutants to Psoralen plus Near-Ultraviolet Radiation

DEFF Research Database (Denmark)

Hansen, M. Trier

1982-01-01

The sensitivity to psoralen plus near-ultraviolet radiation (PUVA) was compared in a pair of E. coli strains differing at the acrA locus. Survival was determined for both bacteria and phage λ. AcrA mutant cells were 40 times more sensitive than wild type to the lethal effect of PUVA. Free λ phage...

Work plan for the Oak Ridge Reservation ecological monitoring and assessment program

International Nuclear Information System (INIS)

Ashwood, T.L.; Sample, B.E.; Suter, G.W. II; Turner, M.G.; Loar, J.M.; Barnthouse, L.W.

1994-08-01

This plan describes an approach for developing an ecological monitoring and assessment program (EMAP) for the US Department of Energy's (DOE's) Oak Ridge Reservation (ORR). Such a program is required to assess existing ecological risks, to predict changes in those ecological risks from proposed remedial actions, and to monitor the effectiveness of remedial actions in reducing ecological risks. Ecological risk assessments must be based on Reservation-level data for those widespread or wide-ranging plant and animal species that occupy the entire ORR. In recognition of this need, Region 4 of the US Environmental Protection Agency has specifically requested that DOE develop a Reservation-wide monitoring and assessment program. The current strategy distinguishes four types of potentially contaminated areas: (1) source operable units (OUs), which may contain waste disposal areas, (2) groundwater aquifers that are potentially contaminated by source OUs, (3) aquatic integrator OUs which are streams and associated floodplains that drain source OUs, and (4) the terrestrial integrator, which encompasses the Reservation. Source OUs may contain sources of contamination that potentially impact local plant and animal population and communities that are restricted to the areal extent of the OU. Such local impacts must be assessed for each OU. However, these source OUs also contribute to risks within the aquatic OUs and within the Reservation-wide terrestrial ecosystem. Therefore, remedial investigations at source OUs must provide data necessary to support ecological risk assessments at the larger scales

Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB

Directory of Open Access Journals (Sweden)

Beibei eWang

2015-04-01

Full Text Available The tripartite efflux pump assembly AcrAB-TolC is the major multidrug resistance transporter in E. coli. The inner membrane transporter AcrB is a homotrimer, energized by the proton movement down the transmembrane electrochemical gradient. The asymmetric crystal structures of AcrB with three monomers in distinct conformational states (access (A, binding (B and extrusion (E support a functional rotating mechanism, in which each monomer of AcrB cycles among the three states in a concerted way. However, the relationship between the conformational changes during functional rotation and drug translocation has not been totally understood. Here, we explored the conformational changes of the AcrB homotrimer during the ABE→BEA transition in different substrate-binding states using targeted MD simulations. It was found that the dissociation of substrate from the distal binding pocket of B monomer is closely related to the concerted conformational changes in the translocation pathway, especially the side chain reorientation of Phe628 and Tyr327. A second substrate binding at the proximal binding pocket of A monomer evidently accelerates the conformational transitions as well as substrate dissociation in B monomer. The acceleration effect of the multi-substrate binding mode provides a molecular explanation for the positive cooperativity observed in the kinetic studies of substrate efflux and deepens our understanding of the functional rotating mechanism of AcrB.

Five-year resurvey for endangered species on Naval Petroleum Reserve No. 1, (Elk Hills), Kern County, California

International Nuclear Information System (INIS)

Otten, M.R.M.; O'Farrell, T.P.; Briden, L.E.

1992-06-01

A transect survey of Naval Petroleum Reserve No. 1 (NPR-1), Kern County, California, was conducted between July 3 and August 5, 1989 to determine the distribution and relative density of endangered species and other wildlife. Results were compared with other reported results, particularly the 1979 and 1984 surveys of NPR-1. A total of 589.8 miles of transects were walked through approximately 47,235 acres in all or parts of 81 sections. Of the 516 San Joaquin kit fox dens observed, 496 were typical subterranean dens and 20 were atypical dens in man-made structures. Estimated den density was 36.7 ± 4.1 per square mile; and relative den density was 10.5/1,000 acres for all of NPR-1. Characteristics of typical kit fox dens were comparable to characteristics reported for other studies, except mean number of entrances per den, which was lower. Observers counted a total of 300 dens previously marked with an identification sign, 191 of which contained at least one complete entrance and would have been observed without a sign. Relative densities of preferred kit fox prey, black-toiled jackrabbits (40.1/1,000 acres) and desert cottontails (14.1/1,000 acres), were lower than previously recorded. Five blunt-nosed leopard lizards were observed along the southwest and northeast perimeter of the Reserve. Most of the 59 giant kangaroo rat burrow systems were observed in the flat terrain along the northeast and south perimeters of the Reserve. San Joaquin antelope squirrels were observed in the central and western parts of NPR- 1. A total of 73 antelope squirrels were observed, and the relative density was 1.511,000 acres. A total.of 30 possible environmental hazards were observed during transect surveys. Most of these were oil and water leaks of small size and appeared to pose little risk to endangered species. Results of this survey indicate that NPR-1 is supporting less wildlife than it did during either the 1979 or 1984 surveys

Discos de acresção em sistemas Be-X

Science.gov (United States)

Lopes de Oliveira, R.; Janot-Pacheco, E.

2003-08-01

Alguns fenômenos de outbursts em Be-X sugerem a existência, mesmo que temporária, de um disco de acresção quando da passagem do objeto compacto pelo periastro orbital. Neste trabalho avaliamos a possibilidade de formação do disco de acresção em sistemas Be+estrela de neutrons e Be+anã branca, e a influência da excentricidade orbital na ocorrência deste fenômeno. Utilizamos a expressão analítica para o momento angular específico da matéria constituinte de um meio em expansão lenta, como é o caso do disco circunstelar das estrelas Be, proposta por Wang(1981), sob a condição básica de que o raio de circularização deva ser maior do que o raio de Alfvén. Concluímos que existe um limite para o período orbital do sistema acima do qual não é possível a formação do disco de acresção, e que este valor aumenta para sistemas com excentricidade orbital maior.

Engineering arsenic tolerance and hyperaccumulation in plants for phytoremediation by a PvACR3 transgenic approach.

Science.gov (United States)

Chen, Yanshan; Xu, Wenzhong; Shen, Hongling; Yan, Huili; Xu, Wenxiu; He, Zhenyan; Ma, Mi

2013-08-20

Arsenic (As) pollution is a global problem, and the plant-based cleanup of contaminated soils, called phytoremediation, is therefore of great interest. Recently, transgenic approaches have been designed to develop As phytoremediation technologies. Here, we used a one-gene transgenic approach for As tolerance and accumulation in Arabidopsis thaliana . PvACR3, a key arsenite [As(III)] antiporter in the As hyperaccumulator fern Pteris vittata , was expressed in Arabidopsis , driven by the CaMV 35S promoter. In response to As treatment, PvACR3 transgenic plants showed greatly enhanced tolerance. PvACR3 transgenic seeds could even germinate and grow in the presence of 80 μM As(III) or 1200 μM arsenate [As(V)] treatments that were lethal to wild-type seeds. PvACR3 localizes to the plasma membrane in Arabidopsis and increases arsenite efflux into external medium in short-term experiments. Arsenic determination showed that PvACR3 substantially reduced As concentrations in roots and simultaneously increased shoot As under 150 μM As(V). When cultivated in As(V)-containing soil (10 ppm As), transgenic plants accumulated approximately 7.5-fold more As in above-ground tissues than wild-type plants. This study provides important insights into the behavior of PvACR3 and the physiology of As metabolism in plants. Our work also provides a simple and practical PvACR3 transgenic approach for engineering As-tolerant and -hyperaccumulating plants for phytoremediation.

Mammography accreditation program

Energy Technology Data Exchange (ETDEWEB)

Wilcox, P.

1993-12-31

In the mid-1980`s, the movement toward the use of dedicated mammography equipment provided significant improvement in breast cancer detection. However, several studies demonstrated that this change was not sufficient to ensure optimal image quality at a low radiation dose. In particular, the 1985 Nationwide Evaluation of X-ray Trends identified the wide variations in image quality and radiation dose, even from dedicated units. During this time period, the American Cancer Society (ACS) launched its Breast Cancer Awareness Screening Campaign. However, there were concerns about the ability of radiology to respond to the increased demand for optimal screening examinations that would result from the ACS program. To respond to these concerns, the ACS and the American College of Radiology (ACR) established a joint committee on mammography screening in 1986. After much discussion, it was decided to use the ACR Diagnostic Practice Accreditation Program as a model for the development of a mammography accreditation program. However, some constraints were required in order to make the program meet the needs of the ACS. This voluntary, peer review program had to be timely and cost effective. It was determined that the best way to address these needs would be to conduct the program by mail. Finally, by placing emphasis on the educational nature of the program, it would provide an even greater opportunity for improving mammographic quality. The result of this effort was that, almost six years ago, in May 1987, the pilot study for the ACR Mammography Accreditation Program (MAP) began, and in August of that year, the first applications were received. In November 1987, the first 3-year accreditation certificates were awarded.

Mammography accreditation program

International Nuclear Information System (INIS)

Wilcox, P.

1993-01-01

In the mid-1980's, the movement toward the use of dedicated mammography equipment provided significant improvement in breast cancer detection. However, several studies demonstrated that this change was not sufficient to ensure optimal image quality at a low radiation dose. In particular, the 1985 Nationwide Evaluation of X-ray Trends identified the wide variations in image quality and radiation dose, even from dedicated units. During this time period, the American Cancer Society (ACS) launched its Breast Cancer Awareness Screening Campaign. However, there were concerns about the ability of radiology to respond to the increased demand for optimal screening examinations that would result from the ACS program. To respond to these concerns, the ACS and the American College of Radiology (ACR) established a joint committee on mammography screening in 1986. After much discussion, it was decided to use the ACR Diagnostic Practice Accreditation Program as a model for the development of a mammography accreditation program. However, some constraints were required in order to make the program meet the needs of the ACS. This voluntary, peer review program had to be timely and cost effective. It was determined that the best way to address these needs would be to conduct the program by mail. Finally, by placing emphasis on the educational nature of the program, it would provide an even greater opportunity for improving mammographic quality. The result of this effort was that, almost six years ago, in May 1987, the pilot study for the ACR Mammography Accreditation Program (MAP) began, and in August of that year, the first applications were received. In November 1987, the first 3-year accreditation certificates were awarded

Geothermal Program Review IV: proceedings

Energy Technology Data Exchange (ETDEWEB)

1985-01-01

The research and development program of DOE's Geothermal Technology Division is reviewed in separate presentations according to program area. Separate abstracts have been prepared for the individual papers. (ACR)

Comparison of neutron parameters between a CANDU and ACR reactors; Comparacao de parametros neutronicos entre um reator CANDU e um ACR

Energy Technology Data Exchange (ETDEWEB)

Dias, Gabriel H.P.; Silva, Clarysson A.M. da; Pereira, Claubia, E-mail: gabrielhpd@yahoo.com.br, E-mail: clarysson@nuclear.ufmg.br, E-mail: claubia@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear

2017-11-01

CANDU (Canadian Deuterium Uranium) is a type of reactor that uses heavy water (D{sub 2}O) as a moderator and as a refrigerant. Despite having chemical characteristics similar to light water (H{sub 2}O), heavy water has a high moderation ratio for neutrons. This feature enables CANDU to use natural uranium as fuel. However, research has evaluated the possibility of using H{sub 2}O as a refrigerant and D{sub 2}O as a moderator aiming at reducing the volume of heavy water. Such changes would imply the use of lightly enriched uranium due to the presence of H{sub 2}O. In this context, the concept of ACR (Advanced CANDU Reactor) has been developed. This reactor has an innovative design which combines of the current CANDU with the characteristics of PWR (Pressurized Water Reactor) type reactors. Studies by AECL (Atomic Energy Canada Limited) show that compared to CANDU, the ACR presents a cost reduction in construction, improved firing performance, improved operation safety and longer life. The present work aims to evaluate, in steady state, some of the main neutron parameters of CANDU-6 and ACR-1000. The MCNPX 2.6.0 code (Monte Carlo N-Particle eXtended -version 2.6.0) was used to simulate such types of reactors. The results show that the models configured in the MCNPX adequately reproduce the neutron behavior of the studied reactors. These models may be used in future work for analysis of fuel burn and evolution.

Endangered species and cultural resources program, Naval Petroleum Reserves in California: Annual report FY95

International Nuclear Information System (INIS)

1996-04-01

In FY95, EG and G Energy Measurements, Inc. (EG and G/EM) continued to support efforts to protect endangered species and cultural resources at the Naval Petroleum Reserves in California (NPRC). These efforts are conducted to ensure NPRC compliance with regulations regarding the protection of listed species and cultural resources on Federal properties. Population monitoring activities are conducted annually for San Joaquin kit foxes, giant kangaroo rats, blunt-nosed leopard lizards, and Hoover's wooly-star. To mitigate impacts of oil field activities on listed species, 674 preactivity surveys covering approximately 211 hectares (521 acres) were conducted in FY95. EG and G/EM also assisted with mitigating effects from third-party projects, primarily by conducting biological and cultural resource consultations with regulatory agencies. EG and G/EM has conducted an applied habitat reclamation program at NPRC since 1985. In FY95, an evaluation of revegetation rates on reclaimed and non-reclaimed disturbed lands was completed, and the results will be used to direct future habitat reclamation efforts at NPRC. In FY95, reclamation success was monitored on 50 sites reclaimed in 1985. An investigation of factors influencing the distribution and abundance of kit foxes at NPRC was initiated in FY94. Factors being examined include habitat disturbance, topography, grazing, coyote abundance, lagomorph abundance, and shrub density. This investigation continued in FY95 and a manuscript on this topic will be completed in FY96. Also, Eg and G/EM completed collection of field data to evaluate the effects of a well blow-out on plant and animal populations. A final report will be prepared in FY96. Finally, EG and G/EM completed a life table analysis on San Joaquin kit foxes at NPRC

OCORRÊNCIA DE Hypsipyla ferrealis Hampson (LEPIDOPTERA: PYRALIDAE EM ANDIROBA NO ESTADO DO ACRE

Directory of Open Access Journals (Sweden)

Rodrigo Souza Santos

2016-01-01

Full Text Available ABSTRACT The occurrence of Hypsipyla ferrealis Hampson was reported in the state of Acre, Brazil, infesting andiroba Retirar as palavras “the county of” da frase, pois municipality é sinônimo de county, ou seja, está em duplicidade no texto esta informação in plastic trays containing moistened sand and placed into a net cage at Embrapa Entomology Laboratory in Acre state. The cage was daily inspected in order to find emerged insects which were identified as Hypsipyla ferrealis , a lepidopteran commonly associated as an andiroba seed pest. This is the first record of this species occurring in andiroba seeds in Acre state.

ISO New England: Results of Ancillary Service Pilot Programs, Alternative Technology Regulation Pilot Program and Demand Response Reserves Pilot Program

Energy Technology Data Exchange (ETDEWEB)

Lowell, Jon [ISO New England, Holyoke, MA (United States); Yoshimura, Henry [ISO New England, Holyoke, MA (United States)

2011-10-26

This PowerPoint presentation compares performance of pilot program assets and generation resources in alternative technology regulation and demand response reserves for flywheels and residential electric thermal storage.

Design features of ACR in severe accident mitigation

International Nuclear Information System (INIS)

Shapiro, H.; Krishnan, V.S.; Santamaura, P.; Lekakh, B.; Blahnik, C.

2007-01-01

New reactor designs require the evaluation of design alternatives to reduce the radiological risk by preventing severe accidents or by limiting releases from the plant in the event of such accidents. The Advanced CANDU Reactor TM (ACR TM ) design has provisions to prevent and mitigate severe accidents. This paper describes key ACR design features for severe accident mitigation. It provides a high-level overview of the findings to date. Several design provisions have not yet been finalized or decided, but the designers are keenly aware of the SAM concepts and their requirements. The active heat sinks for 'vessels' (i.e., the fuel channels, the calandria vessel, the calandria end-shields and the calandria vault) are all amply capable of dissipating the severe accident heat loads. These heat sinks are designed to be operable under severe accident environmental conditions; however, their operability is yet to be confirmed by assessments. The active heat sinks for the various process vessels are 'backed up' by passive heat sinks (i.e., steaming plus water make-up from the RWS). The supply side of passive heat sinks is simple, rugged, and not vulnerable to failures of plant systems. The importance of the steam relief side is recognized, and the adequate relief capacity will be provided. The passive heat sinks will give the SAM more than 1 day (likely several days) to diagnose the accident and to establish the ultimate heat sinks. The spray system for containment pressure suppression is designed for high reliability and has ample capacity to ensure low containment leakage without external intervention, after which time alternative supply to the sprays can be brought on line manually. The sprays are backed up by the LACs which are assessed for operability following a severe accident. The strong ACR containment will provide a long time of completely passive protection for any severe accident at decay power. Its characteristics are not prone to catastrophic failures. The

The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance.

Science.gov (United States)

Seeger, Markus A; Diederichs, Kay; Eicher, Thomas; Brandstätter, Lorenz; Schiefner, André; Verrey, François; Pos, Klaas M

2008-09-01

Antimicrobial resistance of human pathogenic bacteria is an emerging problem for global public health. This resistance is often associated with the overproduction of membrane transport proteins that are capable to pump chemotherapeutics, antibiotics, detergents, dyes and organic solvents out of the cell. In Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, tripartite multidrug efflux systems extrude a large variety of cytotoxic substances from the cell membrane directly into the medium bypassing the periplasm and the outer membrane. In E. coli, the tripartite efflux system AcrA/AcrB/TolC is the pump in charge of the efflux of multiple antibiotics, dyes, bile salts and detergents. The trimeric outer membrane factor (OMF) TolC forms a beta-barrel pore in the outer membrane and exhibits a long periplasmic alpha-helical conduit. The periplasmic membrane fusion protein (MFP) AcrA serves as a linker between TolC and the trimeric resistance nodulation cell division (RND) pump AcrB, located in the inner membrane acting as a proton/drug antiporter. The newly elucidated asymmetric structure of trimeric AcrB reveals three different monomer conformations representing consecutive states in a transport cycle. The monomers show tunnels with occlusions at different sites leading from the lateral side through the periplasmic porter (pore) domains towards the funnel of the trimer and TolC. The structural changes create a hydrophobic pocket in one monomer, which is not present in the other two monomers. Minocyclin and doxorubicin, both AcrB substrates, specifically bind to this pocket substantiating its role as drug binding pocket. The energy transduction from the proton motive force into drug efflux includes proton binding in (and release from) the transmembrane part. The conformational changes observed within a triad of essential, titratable residues (Asp407/Asp408/Lys940) residing in the hydrophobic transmembrane domain appear to be transduced by

AcrA suppressor alterations reverse the drug hypersensitivity phenotype of a TolC mutant by inducing TolC aperture opening

Science.gov (United States)

Weeks, Jon W.; Celaya-Kolb, Teresa; Pecora, Sara; Misra, Rajeev

2010-01-01

Summary In Escherichia coli, the TolC–AcrAB complex forms a major antibiotic efflux system with broad substrate specificity. During the complex assembly, the periplasmic helices and bottom turns of TolC are thought to interact with a hairpin helix of AcrA and hairpin loops of AcrB respectively. In the present study we show that a four-residue substitution in TolC’s turn 1, which connects outer helices 3 and 4 proximal to TolC’s periplasmic aperture, confers antibiotic hypersensitivity without affecting TolC-mediated phage or colicin infection. However, despite the null-like drug sensitivity phenotype, chemical cross-linking analysis revealed no apparent defects in the ability of the mutant TolC protein to physically interact with AcrA and AcrB. A role for TolC turn 1 residues in the functional assembly of the tripartite efflux pump complex was uncovered through isolating suppressor mutations of the mutant TolC protein that mapped within acrA and by utilizing a labile AcrA protein. The data showed that AcrA-mediated suppression of antibiotic sensitivity was achieved by dilating the TolC aperture/channel in an AcrB-dependent manner. The results underscore the importance of the periplasmic turn 1 of TolC in the functional assembly of the tripartite efflux complex and AcrA in transitioning TolC from its closed to open state. PMID:20132445

Economic-environmental energy and reserve scheduling of smart distribution systems: A multiobjective mathematical programming approach

International Nuclear Information System (INIS)

Zakariazadeh, Alireza; Jadid, Shahram; Siano, Pierluigi

2014-01-01

Highlights: • Environmental/economical scheduling of energy and reserve. • Simultaneous participation of loads in both energy and reserve scheduling. • Aggregate wind generation and demand uncertainties in a stochastic model. • Stochastic scheduling of energy and reserve in a distribution system. • Demand response providers’ participation in energy and reserve scheduling. - Abstract: In this paper a stochastic multi-objective economical/environmental operational scheduling method is proposed to schedule energy and reserve in a smart distribution system with high penetration of wind generation. The proposed multi-objective framework, based on augmented ε-constraint method, is used to minimize the total operational costs and emissions and to generate Pareto-optimal solutions for the energy and reserve scheduling problem. Moreover, fuzzy decision making process is employed to extract one of the Pareto-optimal solutions as the best compromise non-dominated solution. The wind power and demand forecast errors are considered in this approach and the reserve can be furnished by the main grid as well as distributed generators and responsive loads. The consumers participate in both energy and reserve markets using various demand response programs. In order to facilitate small and medium loads participation in demand response programs, a Demand Response Provider (DRP) aggregates offers for load reduction. In order to solve the proposed optimization model, the Benders decomposition technique is used to convert the large scale mixed integer non-linear problem into mixed-integer linear programming and non-linear programming problems. The effectiveness of the proposed scheduling approach is verified on a 41-bus distribution test system over a 24-h period

Geochemical exploration for phosphate in the State of Acre

International Nuclear Information System (INIS)

Costa, M.L. da; Melo Costa, W.A. de; Santos, A.J.M. dos

1989-01-01

The geochemical prospecting conducted for phosphates in Acre which could explain the good fertility of the region was charged to discover this material. The phosphates are strictly built of all the bone structures and coprolites of the several fragments of vertebrate fossils, which are widespread in the region. The phosphatic fossils are bedded in the Solimoes Formation, especially its basal to intermediary conglomeratic bed. The fossils are constituted of low crystallinity apatite, and their matrix sediments include quartz, feldspars, smectite, halloysite and calcite. The P 2 O 5 content reaches up to 5% in the sediments and up to 32% in the fragments. The fossils are enriched in U 3 O 8 and rare earth elements. There is no perspect of classic or mineral deposits but the geological knowlwdge will permit the improvement of the use of the soils in Acre. (author) [pt

A National Survey of Conservation Reserve Program (CRP) Participants on Environmental Effects, Wildlife Issues, and Vegetation Management on Program Lands

National Research Council Canada - National Science Library

Allen, Arthur

2003-01-01

A national survey of Conservation Reserve Program (CRP) contractees was completed to obtain information about environmental and social effects of the program on participants, farms, and communities...

Morphometric evaluation of Arbor Acre parent stock broilers reared ...

African Journals Online (AJOL)

Morphometric evaluation of Arbor Acre parent stock broilers reared in ... Economic importance of morphometric parameters such as live weight and body ... (R2) value of 60.30 included forecast indices such as BL, WS, WL, TL, BG and SL.

Leaching Studies on ACR-1000{sup R} Fuel Under Reactor Operating Conditions

Energy Technology Data Exchange (ETDEWEB)

Sunder, S. [Atomic Energy of Canada Limited, Fuel and Fuel Channel Safety Branch, Chalk River, Ontario, K0J 1J0 (Canada)

2009-06-15

ACR-1000{sup R} is the latest nuclear power reactor being developed by AECL. The ACR-1000 fuel uses a modified CANFLEX{sup R} fuel bundle that contains low-enriched uranium and pellets of burnable neutron absorbers (BNA) in a central element. Dysprosium and gadolinium are used as the burnable neutron absorbers and are present as oxides in a 'fully-stabilized' zirconia matrix. The BNA material in the centre element is designed to limit the coolant void reactivity of the reactor core during postulated loss-of-coolant accidents. As part of the ACR-1000 fuel development, the stability of the BNA material under conditions associated with defects of the Zircaloy sheathing of the BNA central element has been investigated. The results of these tests can be used to demonstrate the phase stability and leaching behaviour of the ACR-1000 fuel under reactor operating conditions. The samples were disks, about 3-4 mm thick, obtained from BNA pellets and Candu fuel (natural uranium UO{sub 2}) pellets (the UO{sub 2} measurements provide a reference point). Leaching tests were carried out in light water at 325 deg. C, above the maximum coolant temperature in an ACR-1000 fuel channel during normal operating conditions (319 deg. C). This temperature also bounds the maximum operating temperature for the current Candu reactors (311 deg. C). The initial pH of the solution (measured at room temperature) used in the leaching tests was 10.3. The leach rates were determined by monitoring the amount of metals leached into solutions. Leaching tests were also carried out with BNA pellet samples in the presence of Zr-2.5%Nb pressure tube coupons to determine the effects, if any, of the presence of pressure tube material on leach rates. Other leaching tests with BNA pellet samples and UO{sub 2} pellets were conducted at 80 deg. C to study the effects of temperature on the leach rates. The temperature of 80 deg. C was selected as representative of typical shutdown temperatures

Development of a platform for interactive training ACRs

International Nuclear Information System (INIS)

Gonzalvo, A.; Martin, J. E.; Herrera, J. A.

2013-01-01

Due to the workload of plant personnel and extension courses, you can use other methods of online learning to complement the methods of classroom learning, so that it minimizes disruption to the day job plant day. GNFE is implementing systems on-line training in ACRs based on MOODLE which has many advantages.

77 FR 54607 - Proclaiming Certain Lands, Sugar Parcel Lands, as an Addition to the Bay Mills Indian Reservation...

Science.gov (United States)

2012-09-05

..., as an Addition to the Bay Mills Indian Reservation for the Bay Mills Indian Community of Michigan... acres, more or less, to be added to the Bay Mills Indian Reservation for the Bay Mills Indian Community... the land described below. The land was proclaimed to be an addition to the Bay Mills Indian...

Oak Ridge Y-12 Plant groundwater protection program management plan

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-06-01

The Oak Ridge Y- 1 2 Plant (Y-12 Plant) is owned by the United States Department of Energy (DOE) and managed by Lockheed Martin Energy Systems, Inc. (Energy Systems) under contract No. DE-AC05-84OR21400. The Y-12 Plant Groundwater Protection Program (GWPP), which was initiated in 1975, provides for the protection of groundwater resources consistent with Federal, State, and local regulations, and in accordance with DOE orders and Energy Systems policies and procedures. The Y-12 Plant is located in Anderson County, Tennessee, and is within the corporate limits of the City of Oak Ridge. The Y-12 Plant is one of three major DOE complexes that comprise the 37,000-acre Oak Ridge Reservation (ORR) located in Anderson and Roane counties. The Y-12 Plant is located in Bear Creek Valley at an elevation of about 950 feet (ft) above sea level. Bear Creek Valley is bounded on the northwest and southeast, and is isolated from populated areas of Oak Ridge, by parallel ridges that rise about 300 ft above the valley floor. The Y-12 Plant and its fenced buffer area are about 0.6 mile wide by 3.2 miles long and cover approximately 4,900 acres. The main industrialized section encompasses approximately 800 acres.

Oak Ridge Y-12 Plant groundwater protection program management plan

International Nuclear Information System (INIS)

1996-06-01

The Oak Ridge Y- 1 2 Plant (Y-12 Plant) is owned by the United States Department of Energy (DOE) and managed by Lockheed Martin Energy Systems, Inc. (Energy Systems) under contract No. DE-AC05-84OR21400. The Y-12 Plant Groundwater Protection Program (GWPP), which was initiated in 1975, provides for the protection of groundwater resources consistent with Federal, State, and local regulations, and in accordance with DOE orders and Energy Systems policies and procedures. The Y-12 Plant is located in Anderson County, Tennessee, and is within the corporate limits of the City of Oak Ridge. The Y-12 Plant is one of three major DOE complexes that comprise the 37,000-acre Oak Ridge Reservation (ORR) located in Anderson and Roane counties. The Y-12 Plant is located in Bear Creek Valley at an elevation of about 950 feet (ft) above sea level. Bear Creek Valley is bounded on the northwest and southeast, and is isolated from populated areas of Oak Ridge, by parallel ridges that rise about 300 ft above the valley floor. The Y-12 Plant and its fenced buffer area are about 0.6 mile wide by 3.2 miles long and cover approximately 4,900 acres. The main industrialized section encompasses approximately 800 acres

Stroke Rehabilitation in Frail Elderly with the Robotic Training Device ACRE: A Randomized Controlled Trial and Cost-Effectiveness Study

Directory of Open Access Journals (Sweden)

M. Schoone

2011-01-01

Full Text Available The ACRE (ACtive REhabilitation robotic device is developed to enhance therapeutic treatment of upper limbs after stroke. The aim of this study is to assess effects and costs of ACRE training for frail elderly patients and to establish if ACRE can be a valuable addition to standard therapy in nursing home rehabilitation. The study was designed as randomized controlled trial, one group receiving therapy as usual and the other receiving additional ACRE training. Changes in motor abilities, stroke impact, quality of life and emotional well-being were assessed. In total, 24 patients were included. In this small number no significant effects of the ACRE training were found. A large number of 136 patients were excluded. Main reasons for exclusion were lack of physiological or cognitive abilities. Further improvement of the ACRE can best be focused on making the system suitable for self-training and development of training software for activities of daily living.

Keynote Address: ACR-NEMA standards and their implications for teleradiology

Science.gov (United States)

Horii, Steven C.

1990-06-01

The ACR-NEMA Standard was developed initially as an interface standard for the interconnection of two pieces of imaging equipment Essentially the Standard defmes a point-to-point hardware connection with the necessary protocol and data structure so that two differing devices which meet the specification will be able to communicate with each other. The Standard does not defme a particular PACS architecture nor does it specify a database structure. In part these are the reasons why implementers have had difficulty in using the Standard in a full PACS. Recent activity of the Working Groups formed by the Committee overseeing work on the ACR-NEMA Standard has changed some of the " flavor" of the Standard. It was realized that connection of PACS with hospital and radiology information systems (HIS and RIS) is necessary if a PACS is ever to be succesful. The idea of interconnecting heterogeneous computer systems has pushed Standards development beyond the scope of the original work. Teleradiology which inherenfly involves wide-area networking may be a direct beneficiary of the new directions taken by the Standards Working Groups. This paper will give a brief history of the ACR-NEMA effort describe the " parent" Standard and its " offspring" and describe the activity of the current Working Groups with particular emphasis on the potential impacts on teleradiology.

Ocorrência de Herminodes sp. (Lepidoptera: Noctuidae em pupunheira nos estados do Acre e Rondônia, Brasil Occurrence of Herminodes sp. (Lepidoptera: Noctuidae in peach palm in the States of Acre and Rondônia, Brazil

Directory of Open Access Journals (Sweden)

Marcílio José Thomazini

2004-09-01

Full Text Available É relatado a ocorrência de Herminodes sp. em plantas de pupunha na área experimental da Embrapa Acre, Rio Branco, AC e no Projeto Reca, Vila Nova Califórnia, RO, Brasil. São descritas as principais características deste inseto e os danos por ele causados. Este é o primeiro registro de lagartas do gênero Herminodes causando dano em pupunheiras nos estados do Acre e Rondônia.Related herein is the occurrence of Herminodes sp. in peach palm plants at experimental area of Embrapa Acre, Rio Branco, AC and at Projeto Reca, Vila Nova California, RO, Brazil. The main characteristics of this insect and the damage it causes are described. This is the first record of Herminodes caterpillars damaging peach palm in the states of Acre and Rondônia.

Qualidade da castanha-do-brasil do comércio de Rio Branco, Acre Quality of Brazil nuts marketed in Rio Branco, Acre

Directory of Open Access Journals (Sweden)

Virgínia de Souza Álvares

2012-06-01

Full Text Available Este trabalho teve como objetivo avaliar a qualidade de castanhas-do-brasil beneficiadas e comercializadas em Rio Branco, Acre. Foram analisadas amostras das três marcas de castanha encontradas no mercado local quanto às variáveis: atividade de água, teor de umidade, contagem total de fungos filamentosos, quantificação de Aspergillus flavus e de A. parasiticus, bem como quantificação de aflatoxinas B1, B2, G1 e G2. As castanhas do comércio se encontravam com um teor de umidade e atividade de água adequados, o que pode ter sido responsável pela baixa contaminação por fungos e por aflatoxinas. Quanto a estas micotoxinas, as amostras estão de acordo com o recomendado pela Anvisa, podendo ser esta uma consequência da grande divulgação no Estado do uso de Boas Práticas no manejo da castanha.The goal of this paper was to evaluate the quality of Brazil nuts processed and marketed in the city of Rio Branco, in the state of Acre (Brazil. We analysed three samples for water activity, moisture content, total fungus quantification of Aspergillus flavus and A. parasiticus, as well as quantification of total aflatoxin, Afla B1, Afla B2, Afla G1 and Afla G2. The nut samples from the market showed an appropriate moisture content and water activity, which may have been responsible for the low fungus contamination and aflatoxin production. As to these mycotoxins, the samples were consistent with Anvisa's recommendations, which may be a consequence of good management of the nuts in Acre.

Naval Petroleum and Oil Shale Reserves. Annual report of operations, Fiscal year 1993

International Nuclear Information System (INIS)

1993-01-01

During fiscal year 1993, the reserves generated $440 million in revenues, a $33 million decrease from the fiscal year 1992 revenues, primarily due to significant decreases in oil and natural gas prices. Total costs were $207 million, resulting in net cash flow of $233 million, compared with $273 million in fiscal year 1992. From 1976 through fiscal year 1993, the Naval Petroleum and Oil Shale Reserves generated $15.7 billion in revenues for the US Treasury, with expenses of $2.9 billion. The net revenues of $12.8 billion represent a return on costs of 441 percent. See figures 2, 3, and 4. In fiscal year 1993, production at the Naval Petroleum and Oil Shale Reserves at maximum efficient rates yielded 25 million barrels of crude oil, 123 billion cubic feet of natural gas, and 158 million gallons of natural gas liquids. The Naval Petroleum and Oil Shale Reserves has embarked on an effort to identify additional hydrocarbon resources on the reserves for future production. In 1993, in cooperation with the US Geological Survey, the Department initiated a project to assess the oil and gas potential of the program's oil shale reserves, which remain largely unexplored. These reserves, which total a land area of more than 145,000 acres and are located in Colorado and Utah, are favorably situated in oil and gas producing regions and are likely to contain significant hydrocarbon deposits. Alternatively the producing assets may be sold or leased if that will produce the most value. This task will continue through the first quarter of fiscal year 1994

77 FR 547 - Fiscal Year 2011 Public Transportation on Indian Reservations Program Project Selections

Science.gov (United States)

2012-01-05

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Fiscal Year 2011 Public Transportation... 5311 (c), Public Transportation on Indian Reservations program funds in support of the Tribal Transit... for public transportation services on and around Indian reservations. FOR FURTHER INFORMATION CONTACT...

Joint environmental assessment 1997--2001 of the California Department of Food and Agriculture Curly Top Virus Control Program for Bureau of Land Management and Department of Energy

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-03-01

The DOE, Naval Petroleum reserves in California (NPRC), proposes to sign an Amendment to the Cooperative Agreement and Supplement with the California Department of Food and Agriculture (CDFA) to extend the term of the Curly Top Virus Control Program (CTVCP) in California. This program involves Malathion spraying on NPRC lands to control the beet leafhopper, over a five year period from 1997 through 2001. It is expected that approximately 330 acres on Naval Petroleum Reserve Number 1 (NPR-1) and approximately 9,603 acres on Naval Petroleum Reserve Number 2 (NPR-2) will be treated with Malathion annually by CDFA during the course of this program. The actual acreage subject to treatment can vary from year to year. Pursuant to the requirements of the National Environmental Policy Act of 1969 (NEPA), as amended, the potential impacts of the proposed action were analyzed in a Joint Environmental Assessment (DOE/EA-1011) with the US Department of Interior, Bureau of Land Management (BLM) acting as lead agency, in consultation with the CDFA, and the DOE acting as a cooperating agency. Based on the analysis in the EA, DOE has determined that the conduct of the Curly Top Virus Control Program in California is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the NEPA. Therefore, the preparation of an Environmental Impact Statement is not required and DOE is consequently issuing a FONSI.

Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB

Directory of Open Access Journals (Sweden)

Zhaoshuai eWang

2015-01-01

Full Text Available AcrAB-TolC and their homologs are major multidrug efflux systems in Gram-negative bacteria. The inner membrane component AcrB functions as a trimer. Replacement of Pro223 by Gly in AcrB decreases the trimer stability and drastically reduces the drug efflux activity. The goal of this study is to identify suppressor mutations that restore function to mutant AcrBP223G and explore the mechanism of function recovery. Two methods were used to introduce random mutations into the plasmid of AcrBP223G. Mutants with elevated drug efflux activity were identified, purified, and characterized to examine their expression level, trimer stability, interaction with AcrA, and substrate binding. Nine single-site repressor mutations were identified, including T199M, D256N, A209V, G257V, M662I, Q737L, D788K, P800S, and E810K. Except for M662I, all other mutations located in the docking region of the periplasmic domain. While three mutations, T199M, A209V, and D256N, significantly increased the trimer stability, none of them restored the trimer affinity to the wild type level. M662, the only site of mutation that located in the porter domain, was involved in substrate binding. Our results suggest that the function loss resulted from compromised AcrB trimerization could be restored through various mechanisms involving the compensation of trimer stability and substrate binding.

Methodology for predicting ultimate pressure capacity of the ACR-1000 containment structure

International Nuclear Information System (INIS)

Saudy, A.M.; Awad, A.; Elgohary, M.

2006-01-01

The Advanced CANDU Reactor or the ACR-1000 is developed by Atomic Energy of Canada Limited (AECL) to be the next step in the evolution of the CANDU product line. It is based on the proven CANDU technology and incorporates advanced design technologies. The ACR containment structure is an essential element of the overall defense in depth approach to reactor safety, and is a physical barrier against the release of radioactive material to the environment. Therefore, it is important to provide a robust design with an adequate margin of safety. One of the key design requirements of the ACR containment structure is to have an ultimate pressure capacity that is at least twice the design pressure Using standard design codes, the containment structure is expected to behave elastically at least up to 1.5 times the design pressure. Beyond this pressure level, the concrete containment structure with reinforcements and post-tension tendons behaves in a highly non-linear manner and exhibits a complex response when cracks initiate and propagate. To predict the structural non-linear responses, at least two critical features are involved. These are: the structural idealization by the geometry and material property models, and the adopted solution algorithm. Therefore, detailed idealization of the concrete structure is needed in order to accurately predict its ultimate pressure capacity. This paper summarizes the analysis methodology to be carried out to establish the ultimate pressure capacity of the ACR containment structure and to confirm that the structure meets the specified design requirements. (author)

SU-F-J-143: Initial Assessment of Image Quality of An Integrated MR-Linac System with ACR Phantom

Energy Technology Data Exchange (ETDEWEB)

Wang, J; Fuller, C [MD Anderson Cancer Center, Houston, TX (United States); Yung, J; Kadbi, M; Ding, Y; Ibbott, G [UT MD Anderson Cancer Center, Houston, TX (United States)

2016-06-15

Purpose/Objective(s): To assess the image quality of an integrated MR-Linac system and compare with other MRI systems that are primarily used for diagnostic purposes. Materials/Methods: An ACR MRI quality control (QC) phantom was used to evaluate the image quality of a fully integrated 1.5T MRI-Linac system recently installed at our institution. This system has a new split magnet design which gives the magnetic field strength of 1.5T. All images were acquired with a set of phased-array surface coils which are designed to have minimal attention of radiation beam. The anterior coil rests on a coil holder which keeps the anterior coil’s position consistent for QA purposes. The posterior coil is imbedded in the patient couch. Multiple sets of T1, T2/PD images were acquired using the protocols as prescribed by the ACR on three different dates, ranging 3 months apart. Results: The geometric distortion are within 0.5 mm in the axial scans and within 1mm in the saggital (z-direction) scans. Slice thickness accuracy, image uniformity, ghosting ratio, high contrast detectability are comparable to other 1.5T diagnostic MRI scanners. The low-contrast object detectability are lower comparatively, which is a result of using the body array coil. Additionally, the beam’s-eye-view images (oblique coronal and saggital images) have minimal geometric distortion at all linac gantry angles tested. No observable changes or drift in image quality is found from images acquired 3 month apart. Conclusion: Despite the use of a body array surface coil, the image quality is comparable to that of an 1.5T MRI scanner and is of sufficient quality to pass the ACR MRI accreditation program. The geometric distortion of the MRI system of the integrated MR-Linac is within 1mm for an object size similar to the ACR phantom, sufficient for radiation therapy treatment purpose. The authors received corporate sponsored research grants from Elekta which is the vendor for the MR-Linac evaluated in this

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the regulator AcrR from Escherichia coli

International Nuclear Information System (INIS)

Li, Ming; Qiu, Xi; Su, Chih-Chia; Long, Feng; Gu, Ruoyu; McDermott, Gerry; Yu, Edward W.

2006-01-01

The transcriptional regulator AcrR from Escherichia coli has been cloned, overexpressed, purified and crystallized and X-ray diffraction data have been collected to a resolution of 2.5 Å. This paper describes the cloning, expression, purification and preliminary X-ray data analysis of the AcrR regulatory protein. The Escherichia coli AcrR is a member of the TetR family of transcriptional regulators. It regulates the expression of the AcrAB multidrug transporter. Recombinant AcrR with a 6×His tag at the C-terminus was expressed in E. coli and purified by metal-affinity chromatography. The protein was crystallized using hanging-drop vapor diffusion. X-ray diffraction data were collected from cryocooled crystals at a synchrotron light source. The best crystal diffracted to 2.5 Å. The space group was determined to be P3 2 , with unit-cell parameters a = b = 46.61, c = 166.16 Å

Furfural and hydroxymethylfurfural tolerance in Escherichia coli ΔacrR regulatory mutants.

Science.gov (United States)

Luhe, Annette Lin; Lim, Chan Yuen; Gerken, Henri; Wu, Jinchuan; Zhao, Hua

2015-01-01

The presence of the highly toxic furfural and hydroxymethylfurfural (HMF) in the hydrolysate of lignocellulosic biomass prompted the investigation of the Escherichia coli ΔacrR regulatory mutant for higher tolerance to these compounds, to facilitate the production of biofuels and biochemicals, and further biocatalytic conversions. In comparison with the parental strain, the regulatory mutant with the upregulated efflux pump AcrAB-TolC produced moderately better growth and higher tolerance to concentrations of furfural and HMF between 1 and 2 g L(-1) . © 2014 International Union of Biochemistry and Molecular Biology, Inc.

Comments on the NRC Safety Research Program budget

International Nuclear Information System (INIS)

1979-07-01

This report includes comments on the budget levels and program plans for the supplemental request for FY 1980 to support research related to the accident at Three Mile Island, Unit 2 (TMI) as well as for the FY 1981 Budget. For both budgets, the funding levels considered by the ACRS are the original requests by RES and the Budget Review Group (BRG) markup as of July 10, 1979. In its current review of the NRC research program, the ACRS has given special attention to both the short- and long-term implications of the TMI accident and their significance to research for both the short- and long-term research programs

40 CFR 73.80 - Operation of allowance reserve program for conservation and renewable energy.

Science.gov (United States)

2010-07-01

... for conservation and renewable energy. 73.80 Section 73.80 Protection of Environment ENVIRONMENTAL... and Renewable Energy Reserve § 73.80 Operation of allowance reserve program for conservation and renewable energy. (a) General. The Administrator will allocate allowances from the Conservation and...

The 2013 ACR Commission on Human Resources workforce survey.

Science.gov (United States)

Bluth, Edward I; Truong, Hang; Nsiah, Eugene; Hughes, Danny; Short, Bradley W

2013-10-01

The ACR Commission on Human Resources conducts an annual electronic survey during the first quarter of the year to better understand the present workforce situation for radiologists. We used the Practice of Radiology Environment Database (PRED) to identify 2,067 practice leaders and asked them to complete an electronic survey developed by the Commission on Human Resources. The survey asked group leaders or their designates to report the number of radiologists they currently employ or supervise, the number hired in 2012, and the number they plan to hire in 2013 and 2016. The leaders were also asked to report the subspecialty area that was used as the main reason for hiring that physician. Of the 2,067 practice leaders surveyed, 22% responded, a figure corresponding to 23% of all practicing radiologists in the United States. These results showed that 54% of radiologists are in private practice and 46% are employed by various other entities. The current workforce consists of 21% general radiologists and 79% subspecialists. The largest areas of subspecialty include general interventionalists, neuroradiologists, and body imagers. In 2012, 1,407 radiologists were hired. The greatest number of radiologists hired involved general interventional radiologists, followed by general radiologists, body imagers, and those specializing in musculoskeletal radiology, neuroradiology, and breast imaging. In 2013, 1,526 job opportunities were projected and in 2016, 1,434 job opportunities. In 2013, the most sought-after individuals will be general radiologists, general interventionalists, breast imagers, neuroradiologists, musculoskeletal radiologists, and body imagers. Based on the data collected from the responding practices, the demand for hiring radiologists in 2013 will be similar to 2012. Each of the 1,200 residents who complete their training programs each year should have a position available, but the job may not necessarily be in the subspecialty, geographic area, or type of

Mediator, SWI/SNF and SAGA complexes regulate Yap8-dependent transcriptional activation of ACR2 in response to arsenate.

Science.gov (United States)

Menezes, Regina Andrade; Pimentel, Catarina; Silva, Ana Rita Courelas; Amaral, Catarina; Merhej, Jawad; Devaux, Frédéric; Rodrigues-Pousada, Claudina

2017-04-01

Response to arsenic stress in Saccharomyces cerevisiae is orchestrated by the regulatory protein Yap8, which mediates transcriptional activation of ACR2 and ACR3. This study contributes to the state of art knowledge of the molecular mechanisms underlying yeast stress response to arsenate as it provides the genetic and biochemical evidences that Yap8, through cysteine residues 132, 137, and 274, is the sensor of presence of arsenate in the cytosol. Moreover, it is here reported for the first time the essential role of the Mediator complex in the transcriptional activation of ACR2 by Yap8. Based on our data, we propose an order-of-function map to recapitulate the sequence of events taking place in cells injured with arsenate. Modification of the sulfhydryl state of these cysteines converts Yap8 in its activated form, triggering the recruitment of the Mediator complex to the ACR2/ACR3 promoter, through the interaction with the tail subunit Med2. The Mediator complex then transfers the regulatory signals conveyed by Yap8 to the core transcriptional machinery, which culminates with TBP occupancy, ACR2 upregulation and cell adaptation to arsenate stress. Additional co-factors are required for the transcriptional activation of ACR2 by Yap8, particularly the nucleosome remodeling activity of SWI/SNF and SAGA complexes. Copyright © 2017. Published by Elsevier B.V.

Density and fledging success of ground-nesting passerines in Conservation Reserve Program fields in the northeastern Great Plains

Science.gov (United States)

Koford, Rolf R.

1999-01-01

The Conservation Reserve Program, initiated in 1985, was designed primarily to reduce soil erosion and crop surpluses. A secondary benefit was the provision of habitat for wildlife. Grassland bird populations, many of which declined in the decades prior to the Conservation Reserve Program, may have benefited from the Conservation Reserve Program if reproduction in this newly available habitat has been at least as high as it would have been in the absence of the Conservation Reserve Program. On study areas in North Dakota and Minnesota, I examined breeding densities and fledging success of grassland birds in Conservation Reserve Program fields and in an alternative habitat of similar structure, idle grassland fields on federal Waterfowl Production Areas. Fields were 10 to 25 hectares in size. The avifaunas of these two habitats were similar, although brush-dependent species were more abundant on Waterfowl Protection Areas. The common species in these habitats included ones whose continental populations have declined, such as Grasshopper Sparrow (Ammodramus savannarum), Savannah Sparrow (Passerculus sandwichensis), and Bobolink (Dolichonyx oryzivorus). These ground-nesting species were pooled with other ground nesters in an analysis of fledging success, which revealed no significant differences between habitats, between states, or among years (1991-1993). Predation was the primary cause of nest failure. I concluded that Conservation Reserve Program fields in this region were suitable breeding habitat for several species whose populations had declined prior to the Conservation Reserve Program era. This habitat appeared to be as secure for nests of ground-nesting birds as another suitable habitat in North Dakota and Minnesota.

75 FR 7634 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the Subcommittee on Power Uprates...

Science.gov (United States)

2010-02-22

... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the Subcommittee on Power Uprates; Notice of Meeting The ACRS Subcommittee on Power Uprates will hold a meeting on... arrangements can be made. Thirty-five hard copies of each presentation or handout should be provided to the DFO...

U.S. Department of Energy Naval Petroleum and Oil Shale Reserves combined financial statements, September 30, 1996 and 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-03-01

The Naval Petroleum and Oil Shale Reserves (NPOSR) produces crude oil and associated hydrocarbons from the Naval Petroleum Reserves (NPR) numbered 1, 2, and 3, and the Naval Oil Shale Reserves (NOSR) numbered 1, 2, and 3 in a manner to achieve the greatest value and benefits to the US taxpayer. NPOSR consists of the Naval Petroleum Reserve in California (NPRC or Elk Hills), which is responsible for operations of NPR-1 and NPR-2; the Naval Petroleum Oil Shale Reserve in Colorado, Utah, and Wyoming (NPOSR-CUW), which is responsible for operations of NPR-3, NOSR-1, 2, and 3 and the Rocky Mountain Oilfield Testing Center (RMOTC); and NPOSR Headquarters in Washington, DC, which is responsible for overall program direction. Each participant shares in the unit costs and production of hydrocarbons in proportion to the weighted acre-feet of commercially productive oil and gas formations (zones) underlying the respective surface lands as of 1942. The participating shares of NPR-1 as of September 30, 1996 for the US Government and Chevron USA, Inc., are listed. This report presents the results of the independent certified public accountants` audit of the Department of Energy`s (Department) Naval Petroleum and Oil Shale Reserves (NPOSR) financial statements as of September 30, 1996.

[Motorcycle accidents in the municipality of Rio Branco in the State of Acre: characterization and trends].

Science.gov (United States)

Rocha, Greiciane da Silva; Schor, Néia

2013-03-01

The scope of this paper is to assess traffic accidents involving motorcycles, the victims involved and the increase in the fleet compared with other vehicles in Rio Branco, State of Acre. It is an epidemiological, descriptive and transversal study of accidents between 2005 and 2008 recorded by the Acre State Highway Department. There were 3,582 motorcycle accidents and 3,768 victims in the period. The motorcycle fleet increased by 72.8%, with involvement in accidents increasing by 42.2%, while accidents involving other vehicles only increased by 9.2%. As regards victims, there is a predominance of men, with rates of 561.1, with the age groups of between 20 and 29 and 30 and 39 being the highest, with 755.4 and 542.2, respectively. With reference to accident characteristics, the highest number of accidents - 32.4% - occurred in the afternoon, followed by the morning with 29.2% and the evening with 28.9%. 18.3% occurred on Saturdays and 15.7% on Sundays. Collisions were the commonest kind of accident, with 3,036 (84.8%) occurrences. The conclusion drawn is that it is essential to stage ongoing preventive programs and ensure greater integration among the institutions involved, with planning and campaigns to reverse the current situation.

Computational Study of Correlated Domain Motions in the AcrB Efflux Transporter

Directory of Open Access Journals (Sweden)

Robert Schulz

2015-01-01

Full Text Available As active part of the major efflux system in E. coli bacteria, AcrB is responsible for the uptake and pumping of toxic substrates from the periplasm toward the extracellular space. In combination with the channel protein TolC and membrane fusion protein AcrA, this efflux pump is able to help the bacterium to survive different kinds of noxious compounds. With the present study we intend to enhance the understanding of the interactions between the domains and monomers, for example, the transduction of mechanical energy from the transmembrane domain into the porter domain, correlated motions of different subdomains within monomers, and cooperative effects between monomers. To this end, targeted molecular dynamics simulations have been employed either steering the whole protein complex or specific parts thereof. By forcing only parts of the complex towards specific conformational states, the risk for transient artificial conformations during the simulations is reduced. Distinct cooperative effects between the monomers in AcrB have been observed. Possible allosteric couplings have been identified providing microscopic insights that might be exploited to design more efficient inhibitors of efflux systems.

Subchannel flow analysis in Candu and ACR pressure tubes with radial and axial diameter variation

Energy Technology Data Exchange (ETDEWEB)

Catana, A.; Prodea, L. [RAAN, Institute for Nuclear Research, Arges (Romania); Danila, N.; Prisecaru, I.; Dupleac, D. [Bucharest Univ. Politehnica(Romania)

2007-07-01

The Candu (Canada Deuterium Uranium) and ACR (Advanced Candu Reactor) are pressure tubes (PT) heavy water moderated reactors. Candu are heavy water and ACR are light water cooled reactors. The pressure tube is filled with 12 bundles, each consisting of 37 respectively 43 fuel rods. One Candu reactor is in operation at Cernavoda, Romania since 1996. ACR is a proposed advanced Candu. PT diameter variation has a significant impact on the thermal-hydraulic parameters. Almost all thermal-hydraulic parameters change, but some of them have a greater significance. In this work we have considered a set of radial and axial PT diameter variations both for Candu-600 and ACR-700 reactors using various types of fuel bundles. We can conclude the following: 1) some thermal-hydraulic parameters are significantly influenced: critical heat flux (CHF), pressure drop, or void fraction; 2) the most significant parameter CHF is worsening which reduces the safety margin; 3) some fuel types present a better thermal-hydraulic behavior; and 4) fuel bundles with fresh fuel or low burnup have a worse thermal-hydraulic behaviour than those at average burn-up.

Subchannel flow analysis in Candu and ACR pressure tubes with radial and axial diameter variation

International Nuclear Information System (INIS)

Catana, A.; Prodea, L.; Danila, N.; Prisecaru, I.; Dupleac, D.

2007-01-01

The Candu (Canada Deuterium Uranium) and ACR (Advanced Candu Reactor) are pressure tubes (PT) heavy water moderated reactors. Candu are heavy water and ACR are light water cooled reactors. The pressure tube is filled with 12 bundles, each consisting of 37 respectively 43 fuel rods. One Candu reactor is in operation at Cernavoda, Romania since 1996. ACR is a proposed advanced Candu. PT diameter variation has a significant impact on the thermal-hydraulic parameters. Almost all thermal-hydraulic parameters change, but some of them have a greater significance. In this work we have considered a set of radial and axial PT diameter variations both for Candu-600 and ACR-700 reactors using various types of fuel bundles. We can conclude the following: 1) some thermal-hydraulic parameters are significantly influenced: critical heat flux (CHF), pressure drop, or void fraction; 2) the most significant parameter CHF is worsening which reduces the safety margin; 3) some fuel types present a better thermal-hydraulic behavior; and 4) fuel bundles with fresh fuel or low burnup have a worse thermal-hydraulic behaviour than those at average burn-up

Spatial and spatio-temporal analysis of malaria in the state of Acre, western Amazon, Brazil

Directory of Open Access Journals (Sweden)

Leonardo Augusto Kohara Melchior

2016-11-01

Full Text Available Since 2005, the State of Acre, western Amazon, Brazil, has reported the highest annual parasite incidence (API of malaria among the Brazilian states. This study examines malaria incidence in Acre using spatial and spatio-temporal analysis based on an ecological time series study analyzing malaria cases and deaths for the time period 1992- 2014 and using secondary data. API indexes were calculated by age, sex, parasite species, ratio of Plasmodium vivax to P. falciparum malaria, malaria mortality rate and case fatality rate. SaTScan was used to detect spatial and spatio-temporal clusters of malaria cases and data were represented in the form of choropleth maps. A high-risk cluster of malaria was detected in Vale do Juruá and three low-risk clusters in Vale do Acre for both parasite species. Those younger than 19 years of age and females showed a high incidence of malaria in Vale do Juruá, but working-age males were the most affected in Vale do Acre. The malaria mortality rate showed a decreasing trend across the state, while the case fatality rate increased only in the micro-region of Rio Branco during the study period. We conclude that malaria is a focal disease in Acre showing different spatial and spatio-temporal patterns of cases and deaths that vary by age, sex, and parasite species. Malaria incidence is thought to be influenced by factors related to regional characteristics; therefore, appropriate disease and vector control strategies must be implemented at each locality.

2010-2015 Juvenile fish ecology in the Nisqually River Delta and Nisqually Reach Aquatic Reserve

Science.gov (United States)

Hodgson, Sayre; Ellings, Christopher S.; Rubin, Steve P.; Hayes, Michael C.; Duval, Walker; Grossman, Eric E.

2017-01-01

The return of tidal inundation to over 750 acres of the U. S. Fish and Wildlife Service Billy Frank Jr. Nisqually National Wildlife Refuge (NNWR) in fall of 2009 was the crowning moment in the effort to protect and restore the Nisqually Delta. The Nisqually NWR project complemented three earlier restoration projects completed by the Nisqually Indian Tribe (Tribe) on tribal property to restore over 900 acres of the estuary, representing the largest estuary restoration project in the Pacific Northwest and one of the most significant advances to date towards the recovery of Puget Sound (USFWS 2005). In 2011 the Washington Department of Natural Resources (WADNR established the over 14000 acre Nisqually Reach Aquatic Reserve (Reserve), complementing the protection and restoration successes in the Nisqually Delta. The Reserve includes all state-owned aquatic lands around Anderson, Ketron and Eagle islands and part of McNeil Island (Figure 1, WDNR 2011). The Reserve also includes a diverse assemblage of nearshore and offshore habitats important to resident and migratory fish including federal endangered species act listed fish like Chinook salmon (Oncorynchus tshawytscha) and steelhead (O. mykiss). Studies in the Nisqually Estuary (Ellings and Hodgson 2007, David et al. 2014, Ellings et al. 2016) and South Puget Sound (Duffy 2003) have summarized fish use of the area. However, the fish ecology of the reserve had not been systematically surveyed. The Tribe, U.S. Geological Survey (USGS), NNWR, Nisqually River Foundation (NRF), and others are currently conducting a multi-year, interdisciplinary, hypothesis-based research and monitoring study investigating the impact of delta restoration on estuarine processes, habitat structures, and functions. Our interdisciplinary monitoring framework enables us to link key estuarine processes with habitat development and biological response at multiple scales across the restored footprint, reference marshes, and throughout the Nisqually

Expression of the marA, soxS, acrB and ramA genes related to the AcrAB/TolC efflux pump in Salmonella entérica strains with and without quinolone resistance-determining regions gyrA gene mutations

Directory of Open Access Journals (Sweden)

Rafaela Gomes Ferrari

2013-04-01

Full Text Available Several studies have been conducted in recent years to elucidate the structure, function and significance of AcrB, MarA, SoxS and RamA in Salmonella enterica. In this study, the relative quantification of acrB, soxS, marA and ramA genes expression was evaluated in 14 strains of S. enterica, with or without accompanying mutations in the quinolone resistance-determining regions of the gyrA gene, that were exposed to ciprofloxacin during the exponential growth phase. The presence of ciprofloxacin during the log phase of bacterial growth activated the genes marA, soxS, ramA and acrB in all S. enterica strains analyzed in this study. The highest expression levels for acrB were observed in strains with gyrA mutation, and marA showed the highest expression in the strains without mutation. Considering only the strains with ciprofloxacin minimum inhibitory concentration values 0.125 [1]g/mL (low susceptibility, with and without mutations in gyrA, the most expressed gene was marA. In this study, we observed that strains resistant to nalidixic acid may express genes associated with the efflux pump and the expression of the AcrAB-TolC pump genes seems to occur independently of mutations in gyrA.

Expression of the marA, soxS, acrB and ramA genes related to the AcrAB/TolC efflux pump in Salmonella entérica strains with and without quinolone resistance-determining regions gyrA gene mutations

Directory of Open Access Journals (Sweden)

Rafaela Gomes Ferrari

Full Text Available Several studies have been conducted in recent years to elucidate the structure, function and significance of AcrB, MarA, SoxS and RamA in Salmonella enterica. In this study, the relative quantification of acrB, soxS, marA and ramA genes expression was evaluated in 14 strains of S. enterica, with or without accompanying mutations in the quinolone resistance-determining regions of the gyrA gene, that were exposed to ciprofloxacin during the exponential growth phase. The presence of ciprofloxacin during the log phase of bacterial growth activated the genes marA, soxS, ramA and acrB in all S. enterica strains analyzed in this study. The highest expression levels for acrB were observed in strains with gyrA mutation, and marA showed the highest expression in the strains without mutation. Considering only the strains with ciprofloxacin minimum inhibitory concentration values 0.125 [1]g/mL (low susceptibility, with and without mutations in gyrA, the most expressed gene was marA. In this study, we observed that strains resistant to nalidixic acid may express genes associated with the efflux pump and the expression of the AcrAB-TolC pump genes seems to occur independently of mutations in gyrA.

Stockpiling anti-viral drugs for a pandemic: the role of Manufacturer Reserve Programs.

Science.gov (United States)

Harrington, Joseph E; Hsu, Edbert B

2010-05-01

To promote stockpiling of anti-viral drugs by non-government organizations such as hospitals, drug manufacturers have introduced Manufacturer Reserve Programs which, for an annual fee, provide the right to buy in the event of a severe outbreak of influenza. We show that these programs enhance drug manufacturer profits but could either increase or decrease the amount of pre-pandemic stockpiling of anti-viral drugs.

Contribution of AcrAB-ToIC to multidrug resistance in an Escherichia coli sequence type 131 isolate

NARCIS (Netherlands)

Schuster, Sabine; Vavra, Martina; Schweigger, Tobias M.; Rossen, John W. A.; Matsumura, Yasufumi; Kern, Winfried V.

Drug efflux by resistance-nodulation-cell division (RND)-type transporters, such as AcrAB-ToIC of Escherichia can, is an important resistance mechanism in Gram-negative bacteria; however, its contribution to multidrug resistance (MDR) in clinical isolates is poorly defined. We inactivated acrB of a

Genetic diversity of "Pimenta Longa" genotypes (Piper spp., Piperaceae) of the Embrapa Acre germplasm collection

OpenAIRE

Wadt, Lúcia Helena de Oliveira; Ehringhaus, Christiane; Kageyama, Paulo Yoshio

2004-01-01

The commonly known Pimenta longa is a commercially valuable natural resource found wild in Acre, Brazil. Specifically, three Piperaceae species with contested taxonomic status were studied, Piper hispidinervum, Piper aduncum, and Piper hispidum, to assesses the inter- and intra-specific genetic relationship of 49 Piper genotypes kept in the Pimenta longa germplasm collection at Embrapa Acre, using sixty six Random Amplified Polymorphic DNA (RAPD) markers. The DNA polymorphism level detected w...

Water Reserves Program. An adaptation strategy to balance water in nature

Science.gov (United States)

Lopez Perez, M.; Barrios, E.; Salinas-Rodriguez, S.; Wickel, B.; Villon, R. A.

2013-05-01

Freshwater ecosystems occupy approximately 1% of the earth's surface yet possess about 12% of all known animal species. By virtue of their position in the landscape they connect terrestrial and coastal marine biomes and provide and sustain ecosystem services vital to the health and persistence of human communities. These services include the supply of water for food production, urban and ind ustrial consumption, among others. Over the past century many freshwater ecosystems around the world have been heavily modified or lost due to the alteration of flow regimes (e.g. due to damming, canalization, diversion, over-abstraction). The synergistic impacts of land use change, changes in flows, chemical deterioration, and climate change have left many systems and their species very little room to adjust to change, while future projections indicate a steady increase in water demand for food and energy production and water supply to suit the needs of a growing world population. In Mexico, the focus has been to secure water for human development and maximize economic growth, which has resulted in allocation of water beyond available amounts. As a consequence episodic water scarcity severely constrains freshwater ecosystems and the services they provide. Climatic change and variability are presenting serious challenges to a country that already is experiencing serious strain on its water resources. However, freshwater ecosystems are recognized by law as legitimate user of water, and mandate a flow allocation for the environment ("water reserve" or "environmental flows"). Based on this legal provision the Mexican government through the National Water Commission (Conagua), with support of the Alliance WWF - Fundación Gonzalo Río Arronte, and the Interamerican Development Bank, has launched a national program to identify and implement "water reserves": basins where environmental flows will be secured and allocated and where the flow regime is then protected before over

Otite parasitária causada por Rhabditis (Rhabditis freitasi (Nematoda: Rhabditidae em animais da raça Gir no estado do Acre.

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Francirley , Monteiro e Silva

2016-06-01

Full Text Available The bovine parasitic otitis has been reported in several states of Brazil. It is caused by rhabditiforms nematodes, attacking cattle Gir and Indubrasil breeds. The aim of this work was to describe the occurrence of the disease in animals of the cattle Gir breed in Rio Branco, State of Acre, Brazil. The animals belonged to the Station of Improvement and Animal Genetic Diffusion. Samples were collected from five of these individuals, with swabs aid, conditioned in plastic tubes and kept in alcohol 70%. The specimens were visualized using optical microscopy, and the morphometry was accomplished through a micrometrical ocular. The data were inserted in the Excel spreadsheet, running on Windows 7, and analyzed through descriptive statistics. The animals presented purulent secretion in the external ear canals, shook their heads, showed inquietude and sensibility to the touch during the clinical trials, when intense infestation was observed. One of the individuals died. Animal genetic improvement programs are negatively interfered by infestations like these. It was possible and opportune to find out the moment and place how such illness has entered in the state of Acre. This work aims to help reinforce the importance of future studies to report new cases in the state of Acre.

The introduction of dengue follows transportation infrastructure changes in the state of Acre, Brazil: A network-based analysis.

Science.gov (United States)

Lana, Raquel Martins; Gomes, Marcelo Ferreira da Costa; Lima, Tiago França Melo de; Honório, Nildimar Alves; Codeço, Cláudia Torres

2017-11-01

Human mobility, presence and passive transportation of Aedes aegypti mosquito, and environmental characteristics are a group of factors which contribute to the success of dengue spread and establishment. To understand this process, we assess data from dengue national and municipal basins regarding population and demographics, transportation network, human mobility, and Ae. aegypti monitoring for the Brazilian state of Acre since the first recorded dengue case in the year 2000 to the year 2015. During this period, several changes in Acre's transport infrastructure and urbanization have been started. To reconstruct the process of dengue introduction in Acre, we propose an analytic framework based on concepts used in malaria literature, namely vulnerability and receptivity, to inform risk assessments in dengue-free regions as well as network theory concepts for disease invasion and propagation. We calculate the probability of dengue importation to Acre from other Brazilian states, the evolution of dengue spread between Acrean municipalities and dengue establishment in the state. Our findings suggest that the landscape changes associated with human mobility have created favorable conditions for the establishment of dengue virus transmission in Acre. The revitalization of its major roads, as well as the increased accessibility by air to and within the state, have increased dengue vulnerability. Unplanned urbanization and population growth, as observed in Acre during the period of study, contribute to ideal conditions for Ae. aegypti mosquito establishment, increase the difficulty in mosquito control and consequently its local receptivity.

The Japanese version of the modified ACR preliminary diagnostic criteria for fibromyalgia and the fibromyalgia symptom scale: reliability and validity.

Science.gov (United States)

Usui, Chie; Hatta, Kotaro; Aratani, Satoko; Yagishita, Naoko; Nishioka, Kenya; Kanazawa, Teruhisa; Itoh, Kenji; Yamano, Yoshihisa; Nakamura, Hiroyuki; Nakajima, Toshihiro; Nishioka, Kusuki

2013-09-01

The aim of this study is to investigate the reliability and validity of the Japanese version of the modified American College of Rheumatology (ACR) Preliminary Diagnostic Criteria for Fibromyalgia (mACR 2010-J) and the Fibromyalgia Symptom Scale (mFS-J). According to the ACR 1990 classification criteria, patients with chronic pain were divided into the fibromyalgia group and nonfibromyalgia group (rheumatoid arthritis and osteoarthritis). Patients in both groups were assessed using mACR 2010-J and mFS-J. 294 of 462 (64 %) patients in the fibromyalgia group met mACR 2010-J, whereas 4 % (9/231) of the nonfibromyalgia group did, with sensitivity of 64 %, specificity of 96 %, positive predictive value of 97 %, negative predictive value of 56 %, and positive likelihood ratio of 16.3. Mean total scores on mFS-J significantly differentiated the fibromyalgia from the nonfibromyalgia group. According to the value of the Youden index, the best cutoff score for the mFS-J was 9/10. Our findings indicate that mACR 2010-J as a positive test and mFS-J as a quantification scale might be suitable for assessing fibromyalgia among Japanese chronic pain populations.

78 FR 14820 - Proclaiming Certain Lands as Reservation for the Tohono O'odham Nation of Arizona

Science.gov (United States)

2013-03-07

... the Tohono O'odham Nation of Arizona AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice of... Affairs proclaimed approximately 642.27 acres, more or less, as the Tohono O'odham Nation Indian Reservation for the Tohono O'odham Nation Tribe of Indians of Arizona on February 28, 2013. DATE: The...

Nota sobre culicídeos (Diptera: Culicidae da bacia do rio Purus, Acre, Amazônia (Brasil Note on the culicidae (Diptera: Culicidae of the River Purus Basin, Acre, Amazonian, Brazil

Directory of Open Access Journals (Sweden)

Delsio Natal

1992-04-01

Full Text Available Foram feitas coletas de mosquito (Diptera: Culicidae na área do projeto de Colonização Pedro Peixoto, no Estado do Acre, Brasil. Obteve-se um total de 4.588 exemplares pertencentes a 53 espécies ou grupos. Salienta-se a ocorrência de Anopheles (Nyssorhynchus oswaldoi.Mosquito (Diptera: Culicidae collections were made on the Pedro Peixoto Colonization Project in the State of Acre, Brazil. Four thousand, five hundred and eighty-eight (4,588 specimens were collected and fifty-three (53 species or group recognised. The occurrence of Anopheles (Nyssorhynchus oswaldoi is given special emphasis.

Phytoremediation of arsenic from the contaminated soil using transgenic tobacco plants expressing ACR2 gene of Arabidopsis thaliana.

Science.gov (United States)

Nahar, Noor; Rahman, Aminur; Nawani, Neelu N; Ghosh, Sibdas; Mandal, Abul

2017-11-01

We have cloned, characterized and transformed the AtACR2 gene (arsenic reductase 2) of Arabidopsis thaliana into the genome of tobacco (Nicotiana tabacum, var Sumsun). Our results revealed that the transgenic tobacco plants are more tolerant to arsenic than the wild type ones. These plants can grow on culture medium containing 200μM arsenate, whereas the wild type can barely survive under this condition. Furthermore, when exposed to 100μM arsenate for 35days the amount of arsenic accumulated in the shoots of transgenic plants was significantly lower (28μg/g d wt.) than that found in the shoots of non-transgenic controls (40μg/g d wt.). However, the arsenic content in the roots of transgenic plants was significantly higher (2400μg/g d. wt.) than that (2100μg/g d. wt.) observed in roots of wild type plants. We have demonstrated that Arabidopsis thaliana AtACR2 gene is a potential candidate for genetic engineering of plants to develop new crop cultivars that can be grown on arsenic contaminated fields to reduce arsenic content of the soil and can become a source of food containing no arsenic or exhibiting substantially reduced amount of this metalloid. Copyright © 2017 Elsevier GmbH. All rights reserved.

Study of author’s applied physical training program for military officers-graduates of reserve officers’ departments

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A.I. Yavorskyy

2016-04-01

Full Text Available Purpose: to test effectiveness of applied physical training program for military officers, called up to military service after graduation from reserve officers’ departments. Material: the research was conducted on the base of Educational center 184 from June 2014 to December 2015. In the research 80 military officers participated (n=30 - graduates of military higher educational establishments; n=26, n=24 - graduates of reserve officers’ departments of 22-27 years’ age. Results: we fulfilled analysis of military officers’ physical fitness by exercises, which characterize general physical fitness and military applied skills (100 meters’ run, chin ups, 3000 meters’ run, passing obstacles course, grenade throws for distance and for accuracy, 5 km march-rush. We worked out the program, the essence of which implies ensuring of physical fitness and acceleration of reserve officers-graduates’ adaptation to professional (combat functioning. Conclusions: it was proved that implementation of the author’s program influenced positively on perfection of general physical qualities and military applied skills of military officers-graduated of reserve officers’ departments (р-0.05-0.001.

75 FR 40849 - Implementation of Question 10 of 25 CFR Part 170, Subpart C, Indian Reservation Roads Program

Science.gov (United States)

2010-07-14

... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Implementation of Question 10 of 25 CFR Part 170, Subpart C, Indian Reservation Roads Program AGENCY: Bureau of Indian Affairs, Interior. [[Page... Distribution Factor (RNDF) formula for Indian Reservation Road (IRR) Program funds. The determination is...

Growing a sustainable biofuels industry: economics, environmental considerations, and the role of the Conservation Reserve Program

International Nuclear Information System (INIS)

Clark, Christopher M; Bierwagen, Britta G; Morefield, Philip E; Ridley, Caroline E; Lin, Yolanda; Vimmerstedt, Laura; Bush, Brian W; Eaton, Laurence M; Langholtz, Matthew H; Peterson, Steve

2013-01-01

Biofuels are expected to be a major contributor to renewable energy in the coming decades under the Renewable Fuel Standard (RFS). These fuels have many attractive properties including the promotion of energy independence, rural development, and the reduction of national carbon emissions. However, several unresolved environmental and economic concerns remain. Environmentally, much of the biomass is expected to come from agricultural expansion and/or intensification, which may greatly affect the net environmental impact, and economically, the lack of a developed infrastructure and bottlenecks along the supply chain may affect the industry’s economic vitality. The approximately 30 million acres (12 million hectares) under the Conservation Reserve Program (CRP) represent one land base for possible expansion. Here, we examine the potential role of the CRP in biofuels industry development, by (1) assessing the range of environmental effects on six end points of concern, and (2) simulating differences in potential industry growth nationally using a systems dynamics model. The model examines seven land-use scenarios (various percentages of CRP cultivation for biofuel) and five economic scenarios (subsidy schemes) to explore the benefits of using the CRP. The environmental assessment revealed wide variation in potential impacts. Lignocellulosic feedstocks had the greatest potential to improve the environmental condition relative to row crops, but the most plausible impacts were considered to be neutral or slightly negative. Model simulations revealed that industry growth was much more sensitive to economic scenarios than land-use scenarios—similar volumes of biofuels could be produced with no CRP as with 100% utilization. The range of responses to economic policy was substantial, including long-term market stagnation at current levels of first-generation biofuels under minimal policy intervention, or RFS-scale quantities of biofuels if policy or market conditions were

Involvement of the Acr3 and DctA anti-porters in arsenite oxidation in Agrobacterium tumefaciens 5A.

Science.gov (United States)

Kang, Yoon-Suk; Shi, Zunji; Bothner, Brian; Wang, Gejiao; McDermott, Timothy R

2015-06-01

Microbial arsenite (AsIII) oxidation forms a critical piece of the arsenic cycle in nature, though our understanding of how and why microorganisms oxidize AsIII remains rudimentary. Our model organism Agrobacterium tumefaciens 5A contains two distinct ars operons (ars1 and ars2) that are similar in their coding region content. The ars1 operon is located nearby the aio operon that is essential for AsIII oxidation. The AsIII/H(+) anti-porters encoded by acr3-1 and acr3-2 are required for maximal AsIII and antimonite (SbIII) resistance, but acr3-1 (negatively regulated by ArsR-1) appears more active in this regard and also required for AsIII oxidation and expression of aioBA. A malate-phosphate anti-porter DctA is regulated by RpoN and AsIII, and is required for normal growth with malate as a sole carbon source. Qualitatively, a ΔdctA mutant was normal for AsIII oxidation and AsIII/SbIII resistance at metalloid concentrations inhibitory to the Δacr3-1 mutant; however, aioBA induction kinetics was significantly phase-shift delayed. Acr3 involvement in AsIII/SbIII resistance is reasonably well understood, but the role of Acr3 and DctA anti-porters in AsIII oxidation and its regulation is unexpected, and suggests that controlled AsIII trafficking across the cytoplasmic membrane is important to a process understood to occur in the periplasm. © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.

First report of Rhodnius stali (Hemiptera, Reduviidae, Triatominae in the State of Acre and in the Brazilian Amazon

Directory of Open Access Journals (Sweden)

Dionatas Ulises de Oliveira Meneguetti

2016-06-01

Full Text Available Abstract: INTRODUCTION: This paper reports, for the first time, the presence of Rhodnius stali in the state of Acre and in the Brazilian Amazon. METHODS: Specimens of R. stali were collected by the Federal University of Acre in Rio Branco. RESULTS: The number of Triatominae species in the State of Acre increased from five to six. This was also the first report of R. stali in the Brazilian Amazon. CONCLUSIONS: The occurrence of R. stali is worrisome, since this species has been found naturally infected by Trypanosoma cruzi and there has been evidence of its domiciliation capabilities.

Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity

Energy Technology Data Exchange (ETDEWEB)

Manjasetty, Babu A.; Halavaty, Andrei S.; Luan, Chi-Hao; Osipiuk, Jerzy; Mulligan, Rory; Kwon, Keehwan; Anderson, Wayne F.; Joachimiak, Andrzej

2016-04-01

Multidrug transcription regulator AcrR from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 belongs to the tetracycline repressor family, one of the largest groups of bacterial transcription factors. The crystal structure of dimeric AcrR was determined and refined to 1.56 Å resolution. The tertiary and quaternary structures of AcrR are similar to those of its homologs. The multidrug binding site was identified based on structural alignment with homologous proteins and has a di(hydroxyethyl)ether molecule bound. Residues from helices a4 and a7 shape the entry into this binding site. The structure of AcrR reveals that the extended helical conformation of helix a4 is stabilized by the hydrogen bond between Glu67 (helix a4) and Gln130 (helix a7). Based on the structural comparison with the closest homolog structure, the Escherichia coli AcrR, we propose that this hydrogen bond is responsible for control of the loop-to-helix transition within helix a4. This local conformational switch of helix a4 may be a key step in accessing the multidrug binding site and securing ligands at the binding site. Solution smallmolecule binding studies suggest that AcrR binds ligands with their core chemical structure resembling the tetracyclic ring of cholesterol.

InfAcrOnt: calculating cross-ontology term similarities using information flow by a random walk.

Science.gov (United States)

Cheng, Liang; Jiang, Yue; Ju, Hong; Sun, Jie; Peng, Jiajie; Zhou, Meng; Hu, Yang

2018-01-19

Since the establishment of the first biomedical ontology Gene Ontology (GO), the number of biomedical ontology has increased dramatically. Nowadays over 300 ontologies have been built including extensively used Disease Ontology (DO) and Human Phenotype Ontology (HPO). Because of the advantage of identifying novel relationships between terms, calculating similarity between ontology terms is one of the major tasks in this research area. Though similarities between terms within each ontology have been studied with in silico methods, term similarities across different ontologies were not investigated as deeply. The latest method took advantage of gene functional interaction network (GFIN) to explore such inter-ontology similarities of terms. However, it only used gene interactions and failed to make full use of the connectivity among gene nodes of the network. In addition, all existent methods are particularly designed for GO and their performances on the extended ontology community remain unknown. We proposed a method InfAcrOnt to infer similarities between terms across ontologies utilizing the entire GFIN. InfAcrOnt builds a term-gene-gene network which comprised ontology annotations and GFIN, and acquires similarities between terms across ontologies through modeling the information flow within the network by random walk. In our benchmark experiments on sub-ontologies of GO, InfAcrOnt achieves a high average area under the receiver operating characteristic curve (AUC) (0.9322 and 0.9309) and low standard deviations (1.8746e-6 and 3.0977e-6) in both human and yeast benchmark datasets exhibiting superior performance. Meanwhile, comparisons of InfAcrOnt results and prior knowledge on pair-wise DO-HPO terms and pair-wise DO-GO terms show high correlations. The experiment results show that InfAcrOnt significantly improves the performance of inferring similarities between terms across ontologies in benchmark set.

Integrating the ACR Appropriateness Criteria Into the Radiology Clerkship: Comparison of Didactic Format and Group-Based Learning.

Science.gov (United States)

Stein, Marjorie W; Frank, Susan J; Roberts, Jeffrey H; Finkelstein, Malka; Heo, Moonseong

2016-05-01

The aim of this study was to determine whether group-based or didactic teaching is more effective to teach ACR Appropriateness Criteria to medical students. An identical pretest, posttest, and delayed multiple-choice test was used to evaluate the efficacy of the two teaching methods. Descriptive statistics comparing test scores were obtained. On the posttest, the didactic group gained 12.5 points (P didactic group gained 14.4 points (P didactic lectures, group-based learning is more enjoyable, time efficient, and equally efficacious. The choice of educational method can be individualized for each institution on the basis of group size, time constraints, and faculty availability. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

ACR appropriateness criteria blunt chest trauma.

Science.gov (United States)

Chung, Jonathan H; Cox, Christian W; Mohammed, Tan-Lucien H; Kirsch, Jacobo; Brown, Kathleen; Dyer, Debra Sue; Ginsburg, Mark E; Heitkamp, Darel E; Kanne, Jeffrey P; Kazerooni, Ella A; Ketai, Loren H; Ravenel, James G; Saleh, Anthony G; Shah, Rakesh D; Steiner, Robert M; Suh, Robert D

2014-04-01

Imaging is paramount in the setting of blunt trauma and is now the standard of care at any trauma center. Although anteroposterior radiography has inherent limitations, the ability to acquire a radiograph in the trauma bay with little interruption in clinical survey, monitoring, and treatment, as well as radiography's accepted role in screening for traumatic aortic injury, supports the routine use of chest radiography. Chest CT or CT angiography is the gold-standard routine imaging modality for detecting thoracic injuries caused by blunt trauma. There is disagreement on whether routine chest CT is necessary in all patients with histories of blunt trauma. Ultimately, the frequency and timing of CT chest imaging should be site specific and should depend on the local resources of the trauma center as well as patient status. Ultrasound may be beneficial in the detection of pneumothorax, hemothorax, and pericardial hemorrhage; transesophageal echocardiography is a first-line imaging tool in the setting of suspected cardiac injury. In the blunt trauma setting, MRI and nuclear medicine likely play no role in the acute setting, although these modalities may be helpful as problem-solving tools after initial assessment. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Morphometric traits in arbor-acres broiler chicken ( Gallus gallus )fed ...

African Journals Online (AJOL)

Fifty sixth day morphometric and body weight measurements were taken on one hundred and forty eight Arbor Acres broiler chickens reared under the Deep Litter system in the guinea savana Zone of Nigeria. This study aimed to determine the effects of substituting treated and untreated Cocoa Bean Shell (CBS) at 50 and ...

Assessment of the release program of the European Roe Deer Capreolus capreolus (Cetartiodactyla: Cervidae at Ajloun Nature Reserve, Jordan

Directory of Open Access Journals (Sweden)

E.K. Eid

2009-06-01

Full Text Available The release program of European Roe Deer Capreolus capreolus was launched in 1989 when the Royal Society for the Conservation of Nature (RSCN received a donation of four individuals (two males and two females from Turkish-Bulgarian border. The aim of the program was to establish a viable population in the former habitat of the species. The program was ongoing for almost 18 years at Ajloun Forest Reserve. On 19 January 2006, 26 individuals (11 males and 15 females were released in the reserve. After collecting information relating to the breeding and release program, a rapid assessment survey was conducted during August and September 2007. Based on visual census, spoor routes, opportunistic observations and interviews method, a distribution map was produced and it was found that the released population had dispersed inside the reserve. Occasionally, they were found to have wandered outside the reserve, where they used surrounding vineyards for feeding and resting; a total of four individuals of two males and two females were counted. The RSCN has succeeded in establishing a free viable population, in its natural habitat, using effective long-term on-site management. It would be recommendable to establish a socio-economic program, and ongoing outreach programs in order to raise the awareness of the importance of protecting endangered species, and secure continuous funding. a further recommendation would be to provide training in deer management for the ecologist and further staff on the reserve and to implement a monitoring program for the released herd in order to insure the success of the reintroduction program.

Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity.

Science.gov (United States)

Manjasetty, Babu A; Halavaty, Andrei S; Luan, Chi-Hao; Osipiuk, Jerzy; Mulligan, Rory; Kwon, Keehwan; Anderson, Wayne F; Joachimiak, Andrzej

2016-04-01

Multidrug transcription regulator AcrR from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 belongs to the tetracycline repressor family, one of the largest groups of bacterial transcription factors. The crystal structure of dimeric AcrR was determined and refined to 1.56Å resolution. The tertiary and quaternary structures of AcrR are similar to those of its homologs. The multidrug binding site was identified based on structural alignment with homologous proteins and has a di(hydroxyethyl)ether molecule bound. Residues from helices α4 and α7 shape the entry into this binding site. The structure of AcrR reveals that the extended helical conformation of helix α4 is stabilized by the hydrogen bond between Glu67 (helix α4) and Gln130 (helix α7). Based on the structural comparison with the closest homolog structure, the Escherichia coli AcrR, we propose that this hydrogen bond is responsible for control of the loop-to-helix transition within helix α4. This local conformational switch of helix α4 may be a key step in accessing the multidrug binding site and securing ligands at the binding site. Solution small-molecule binding studies suggest that AcrR binds ligands with their core chemical structure resembling the tetracyclic ring of cholesterol. Copyright © 2016. Published by Elsevier Inc.

Effects of wind turbines on upland nesting birds in Conservation Reserve Program grasslands

Science.gov (United States)

Leddy, K.L.; Higgins, K.F.; Naugle, D.E.

1999-01-01

Grassland passerines were surveyed during summer 1995 on the Buffalo Ridge Wind Resource Area in southwestern Minnesota to determine the relative influence of wind turbines on overall densities of upland nesting birds in Conservation Reserve Program (CRP) grasslands. Birds were surveyed along 40 m fixed width transects that were placed along wind turbine strings within three CRP fields and in three CRP fields without turbines. Conservation Reserve Program grasslands without turbines and areas located 180 m from turbines supported higher densities (261.0-312.5 males/100 ha) of grassland birds than areas within 80 m of turbines (58.2-128.0 males/100 ha). Human disturbance, turbine noise, and physical movements of turbines during operation may have disturbed nesting birds. We recommend that wind turbines be placed within cropland habitats that support lower densities of grassland passerines than those found in CRP grasslands.

Diverse characteristics of wetlands restored under the Wetlands Reserve Program in the Southeastern United States

Science.gov (United States)

Diane De Steven; Joel M. Gramling

2012-01-01

The Wetlands Reserve Program (WRP) restores converted or degraded wetlands on private working lands; however, the nature and outcomes of such efforts are undocumented in the Southeastern U.S. Identification of wetland types is needed to assess the program's conservation benefits, because ecological functions differ with hydrogeomorphic (HGM) type. We reviewed...

Validity and reliability problems with patient global as a component of the ACR/EULAR remission criteria as used in clinical practice.

Science.gov (United States)

Masri, Karim R; Shaver, Timothy S; Shahouri, Shadi H; Wang, Shirley; Anderson, James D; Busch, Ruth E; Michaud, Kaleb; Mikuls, Ted R; Caplan, Liron; Wolfe, Frederick

2012-06-01

To investigate what factors influence patient global health assessment (PtGlobal), and how those factors and the reliability of PtGlobal affect the rate, reliability, and validity of recently published American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) rheumatoid arthritis (RA) remission criteria when used in clinical practice. We examined consecutive patients with RA in clinical practice and identified 77 who met ACR/EULAR joint criteria for remission (≤ 1 swollen joint and ≤ 1 tender joint). We evaluated factors associated with a PtGlobal > 1, because a PtGlobal ≤ 1 defined ACR/EULAR remission in this group of patients who had already met ACR/EULAR joint criteria. Of the 77 patients examined, only 17 (22.1%) had PtGlobal ≤ 1 and thus fully satisfied ACR/EULAR criteria. A large proportion of patients not in remission by ACR/EULAR criteria had high PtGlobal related to noninflammatory issues, including low back pain, fatigue, and functional limitations, and a number of patients clustered in the range of PtGlobal > 1 and ≤ 2. However, the minimal detectable difference for PtGlobal was 2.3. In addition, compared with a PtGlobal severity score, a PtGlobal activity score was 3.3% less likely to be abnormal (> 1). Noninflammatory factors contribute to the level of PtGlobal and result in the exclusion of many patients who would otherwise be in "true" remission according to the ACR/EULAR definition. Reliability problems associated with PtGlobal can also result in misclassification, and may explain the observation of low longterm remission rates in RA. As currently constituted, the use of the ACR/EULAR remission criteria in clinical practice appears to be problematic.

SUBSURFACE DESIGN SUPPORT LOW THERMAL LOAD REPOSITORY (25 MTU/ACRE)

International Nuclear Information System (INIS)

T.M. Lahnalampi

1999-01-01

The objective of this document is to present a comparison between the Viability Assessment Design Layout and a 25 MTU/acre conceptual repository design. The scope of this analysis is comparing the linear dimensions and the quantities of the major design elements, for example, emplacement drifts, perimeter mains, exhaust mains, performance confirmation drifts, connecting ramps and vertical development

Desempenho de cultivares de alface no Estado do Acre Performance of lettuce cultivars in the State of Acre, Brazil

Directory of Open Access Journals (Sweden)

Francisco J. da S. Lédo

2000-11-01

Full Text Available Devido às condições ambientais verificadas no estado do Acre, caracterizado pela ocorrência de temperaturas elevadas e alta precipitação, as cultivares tradicionalmente utilizadas pelos produtores apresentam baixo rendimento e qualidade. O objetivo do presente trabalho foi avaliar o comportamento das novas cultivares de alface disponíveis no mercado, em termos de características agronômicas e rendimento, nas condições edafoclimáticas de Rio Branco, Acre. Para isso foram realizados dois ensaios no campo experimental da Embrapa Acre, em um solo do tipo Argissolo Vermelho-Escuro, textura argilosa. O primeiro de maio a julho de 1996 (período seco e o segundo de dezembro de 1996 a fevereiro de 1997 (período chuvoso. Foram avaliadas as cultivares Babá de Verão, Brisa, Carolina AG-576, Elisa, Lucy Brown, Marisa AG-216, Piracicaba 65, Regina 71, Tainá, Simpson, Vanessa e Verônica, sendo que 'Regina 71' e 'Elisa' foram incluídas apenas no ensaio do período seco. O delineamento experimental foi o de blocos casualizados, com três repetições. No período seco, as cultivares Simpson, Lucy Brown e Regina 71 apresentaram os maiores pesos médios (373; 362 e 341 g, respectivamente e produções comerciais de 49,8; 48,3 e 45,5 t/ha, respectivamente. Em geral, as cultivares dos tipos lisa sem cabeça e lisa com cabeça apresentaram maior índice de ataque de nematóide (Meloidogyne javanica quando comparadas às do tipo crespa. No ensaio realizado no período chuvoso, as cultivares Marisa AG-216, Verônica, Lucy Brown, Brisa, Tainá e Piracicaba-65 apresentaram os maiores pesos médios e produções comerciais. Entretanto, as médias obtidas foram bem inferiores às verificadas no ensaio do período seco, variando de 164 a 198 g para o peso médio, e 21,9 a 25,9 t/ha para produção comercial. Dentre as cultivares avaliadas no período seco, Regina 71 (lisa, sem cabeça e Carolina AG-576 (lisa, com cabeça destacaram-se entre as do tipo

School-Family Partnership for Coexistence (SFPC) in the City of Acre: Promoting Arab and Jewish Parents' Role as Facilitators of Children's Literacy Development and as Agents of Coexistence

Science.gov (United States)

Zelniker, Tamar; Hertz-Lazarowitz, Rachel

2005-01-01

A two-year (1998-2000) School-Family Partnership for Coexistence (SFPC) programme was implemented in Acre, a mixed Jewish-Arab city in Israel, to promote parents' role as facilitators of their children literacy development and to empower parents to advance coexistence and inter-group relations. The SFPC program was part of a five-year (1995-2000)…

Distribuição e impacto da sigatoka-negra na bananicultura do estado do Acre

OpenAIRE

Cavalcante, Maria de Jesus B.; Sá, Claudenor P. de; Gomes, Francisco C. da Rocha; Gondim, Tarcísio M. de Souza; Cordeiro, Zilton J. M.; Hessel, Jorge L.

2004-01-01

A sigatoka-negra (Mycosphaerella fijiensis) é a doença de maior severidade que afeta as cultivares de banana (Musa spp.) de importância econômica no mundo. Foi constatada no Brasil em 1998, no Estado do Amazonas, e tem se disseminado pelo Estado do Acre, atacando severamente as cultivares do Subgrupo Terra (AAB). Realizou-se um diagnóstico da sigatoka-negra e dos impactos econômicos causados por esta doença nos municípios do Estado do Acre. Foram visitados plantios em 16 municípios e amostras...

Evapotranspiration Cover for the 92-Acre Area Retired Mixed Waste Pits:Interim CQA Report

International Nuclear Information System (INIS)

2011-01-01

This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. Construction was approved by the Nevada Division of Environmental Protection (NDEP) under the Approval of Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) for Corrective Action Unit (CAU) 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada, on January 6, 2011, pursuant to Subpart XII.8a of the Federal Facility Agreement and Consent Order. The project is located in Area 5 of the Radioactive Waste Management Complex (RWMC) at the Nevada National Security Site (NNSS), formerly known as the Nevada Test Site, located in southern Nevada, approximately 65 miles northwest of Las Vegas, Nevada, in Nye County. The project site, in Area 5, is located in a topographically closed basin approximately 14 additional miles north of Mercury Nevada, in the north-central part of Frenchman Flat. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste. The 92-Acre Area encompasses the southern portion of the Area 5 RWMS, which has been designated for the first final closure operations. This area contains 13 Greater Confinement Disposal (GCD) boreholes, 16 narrow trenches, and 9 broader pits. With the exception of two active pits (P03 and P06), all trenches and pits in the 92-Acre Area had operational covers approximately 2.4 meters thick, at a minimum, in most areas when this project began. The units within the 92-Acre Area are grouped into the following six informal categories based on physical location

Evapotranspiration Cover for the 92-Acre Area Retired Mixed Waste Pits:Interim CQA Report

Energy Technology Data Exchange (ETDEWEB)

The Delphi Groupe, Inc., and J. A. Cesare and Associates, Inc.

2011-06-20

This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. Construction was approved by the Nevada Division of Environmental Protection (NDEP) under the Approval of Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) for Corrective Action Unit (CAU) 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada, on January 6, 2011, pursuant to Subpart XII.8a of the Federal Facility Agreement and Consent Order. The project is located in Area 5 of the Radioactive Waste Management Complex (RWMC) at the Nevada National Security Site (NNSS), formerly known as the Nevada Test Site, located in southern Nevada, approximately 65 miles northwest of Las Vegas, Nevada, in Nye County. The project site, in Area 5, is located in a topographically closed basin approximately 14 additional miles north of Mercury Nevada, in the north-central part of Frenchman Flat. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste. The 92-Acre Area encompasses the southern portion of the Area 5 RWMS, which has been designated for the first final closure operations. This area contains 13 Greater Confinement Disposal (GCD) boreholes, 16 narrow trenches, and 9 broader pits. With the exception of two active pits (P03 and P06), all trenches and pits in the 92-Acre Area had operational covers approximately 2.4 meters thick, at a minimum, in most areas when this project began. The units within the 92-Acre Area are grouped into the following six informal categories based on physical location

Combating obsolescence - ACR digital control systems design

International Nuclear Information System (INIS)

Tikku, S.; Raiskums, G.

2006-01-01

The ever increasing use of digital technologies and products to meet the control, automation and monitoring needs of the nuclear power plant - even though justified by the benefits it provides - comes with an increased risk of technological obsolescence happening through the course of the plant life. Some well considered strategies are being employed in the ACR design process to minimise this risk and alleviate the consequence if it happens. These include application of a modular overall architecture, adoption of international widely accepted standards to harmonise equipment qualification and software practices, production of control functional specifications that are not influenced by target platform, and careful selection of technologies and products. (author)

Management of conservation reserve program grasslands to meet wildlife habitat objectives

Science.gov (United States)

Vandever, Mark W.; Allen, Arthur W.

2015-01-01

Numerous studies document environmental and social benefits of the Conservation Reserve Program (CRP). This report offers a synopsis of findings regarding effects of establishing CRP conservation practices on the quality and distribution of wildlife habitat in agricultural landscapes. On individual farms, year-round provision of wildlife habitat by the CRP may appear relatively insignificant. However, considered from multi-farm to National scales, such improvements in habitat and wildlife response have proven to be extensive and profound.

Assessment of ACR moderator circulation design using CFD

International Nuclear Information System (INIS)

Bunama, R.; Carlucci, L.N.; Waddington, G.M.

2004-01-01

Assessment of the thermalhydraulic performance of the moderator circulation system for the Advanced CANDU Reactor (ACR) was carried out using the specialized Computational Fluid Dynamics (CFD) code MODTURC C LAS V2.9 IST. The assessment included modeling the moderator circulation inside the calandria vessel under nominal and isothermal flow conditions. The modeling results show that the moderator flow through the core is relatively uniform and mostly upward. The moderator temperature distribution is nearly stratified and increases monotonically from the bottom to the top of the calandria vessel. (author)

ART Or AGR: Deciphering Which Reserve Program is Best Suited for Today’s Total Force Structure

Science.gov (United States)

2016-02-01

AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY ART OR AGR: DECIPHERING WHICH RESERVE PROGRAM IS BEST SUITED FOR TODAY’S TOTAL FORCE STRUCTURE...4 ART Program...time workforce, which are the ART and AGR programs, by comparing each and highlighting the differences, advantages and disadvantages they present to

Landowner Satisfaction with the Wetland Reserve Program in Texas: A Mixed-Methods Analysis

Science.gov (United States)

Stroman, Dianne; Kreuter, Urs P.

2016-01-01

Using mail survey data and telephone interviews, we report on landowner satisfaction with permanent easements held by the Natural Resources Conservation Service (NRCS) throughout Texas. This study found that landowners were dissatisfied with the NRCS Wetland Reserve Program (WRP), conflicting with results of previous studies. The objective of this study was to explore specific reasons for frustration expressed by landowners with the program. We found three predominant themes underpinning program dissatisfaction: (1) upfront restoration failures, (2) overly restrictive easement constraints, and (3) bureaucratic hurdles limiting landowners' ability to conduct adaptive management on their easement property. The implications of this study suggest that attitudes of landowners participating in the WRP may limit the long-term effectiveness of this program. Suggestions for improving the program include implementing timely, ecologically sound restoration procedures and streamlining and simplifying the approval process for management activity requests. In addition, the NRCS should consider revising WRP restriction guidelines in order to provide more balance between protection goals and landowner autonomy.

Endangered Species Program, Naval Petroleum Reserves in California. Annual report FY93

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-02-01

The Naval Petroleum Reserves in California (NPRC) are operated by the US Department of Energy (DOE) and Chevron USA. Production Company (CPDN). Four federally-listed endangered animal species and one federally-threatened plant species are known to occur on NPRC: San Joaquin kit fox, blunt-nosed leopard lizard, giant kangaroo rat, Tipton kangaroo rat, and Hoover`s wooly-star. All five are protected under the Endangered Species Act of 1973, which declares that it is ``...the policy of Congress that all Federal departments and agencies shall seek to conserve endangered species and threatened species and shall utilize their authorities in furtherance of the purposes of the Act.`` DOE is also obliged to determine whether actions taken by their lessees on Naval Petroleum Reserve No. 2 will have any effects on endangered species or their habitats. The major objective of the EG&G Energy Measurements, Inc. Endangered Species Program on NPRC is to provide DOE with the scientific expertise necessary for compliance with the Endangered Species Act. The specific objective of this report is to summarize progress and results of the Endangered Species Program made during fiscal year 1993.

Variación de la estructura fina de las fibras acrílicas en la hilatura

OpenAIRE

Gacén Guillén, Joaquín; Maillo Garrido, Josefina; Manich i Bou, Albert Mª; Ussmane, Mahomed

2002-01-01

[ESP] Dos fibras acrílicas comerciales de diferente finura han sido transformadas en hilados en continua de hilar (3.3. dtex) y en hilatura de rotor (1.3 dtex). Los hilos resultantes han sido vaporizados y teñidos en condiciones standard. Las variaciones de la estructura producidas por las operaciones de hilatura, vaporizado y tintura han sido evaluadas a través del ensayo de solubilidad de las fibras acrílicas en una mezcla dimetilformamida/agua (95/5).

75 FR 73911 - Grassland Reserve Program

Science.gov (United States)

2010-11-29

... the program are being achieved; (4) To track participation by crop and livestock type; and (5) To... regulations in Sec. 1415.4 ``Program requirements,'' Sec. 1415.11 ``Restoration agreements,'' and Sec. 1415.17...://ias.sc.egov.usda.gov/PRSHOME/ . Program performance also is reported annually to Congress and the...

Evaluation of the ACR and SLICC classification criteria in juvenile-onset systemic lupus erythematosus: a longitudinal analysis.

Science.gov (United States)

Lythgoe, H; Morgan, T; Heaf, E; Lloyd, O; Al-Abadi, E; Armon, K; Bailey, K; Davidson, J; Friswell, M; Gardner-Medwin, J; Haslam, K; Ioannou, Y; Leahy, A; Leone, V; Pilkington, C; Rangaraj, S; Riley, P; Tizard, E J; Wilkinson, N; Beresford, M W

2017-10-01

Objectives The Systemic Lupus International Collaborating Clinics (SLICC) group proposed revised classification criteria for systemic lupus erythematosus (SLICC-2012 criteria). This study aimed to compare these criteria with the well-established American College of Rheumatology classification criteria (ACR-1997 criteria) in a national cohort of juvenile-onset systemic lupus erythematosus (JSLE) patients and evaluate how patients' classification criteria evolved over time. Methods Data from patients in the UK JSLE Cohort Study with a senior clinician diagnosis of probable evolving, or definite JSLE, were analyzed. Patients were assessed using both classification criteria within 1 year of diagnosis and at latest follow up (following a minimum 12-month follow-up period). Results A total of 226 patients were included. The SLICC-2012 was more sensitive than ACR-1997 at diagnosis (92.9% versus 84.1% p < 0.001) and after follow up (100% versus 92.0% p < 0.001). Most patients meeting the SLICC-2012 criteria and not the ACR-1997 met more than one additional criterion on the SLICC-2012. Conclusions The SLICC-2012 was better able to classify patients with JSLE than the ACR-1997 and did so at an earlier stage in their disease course. SLICC-2012 should be considered for classification of JSLE patients in observational studies and clinical trial eligibility.

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2.

Science.gov (United States)

Manjasetty, Babu A; Halavaty, Andrei S; Luan, Chi-Hao; Osipiuk, Jerzy; Mulligan, Rory; Kwon, Keehwan; Anderson, Wayne F; Joachimiak, Andrzej

2016-06-01

The fluorescence-based thermal shift (FTS) data presented here include Table S1 and Fig. S1, and are supplemental to our original research article describing detailed structural, FTS, and fluorescence polarization analyses of the Salmonella enterica subsp. entrica serovar Typhimurium str. LT2 multidrug transcriptional regulator AcrR (StAcrR) (doi:10.1016/j.jsb.2016.01.008) (Manjasetty et al., 2015 [1]). Table S1 contains chemical formulas, a Chemical Abstracts Service (CAS) Registry Number (CAS no.), FTS rank (a ligand with the highest rank) has the largest difference in the melting temperature (ΔT m), and uses as drug molecules against various pathological conditions of sixteen small-molecule ligands that increase thermal stability of StAcrR. Thermal stability of human enolase 1, a negative control protein, was not affected in the presence of various concentrations of the top six StAcrR binders (Fig. S1).

ACR Appropriateness Criteria Assessment of Fetal Well-Being.

Science.gov (United States)

Simpson, Lynn; Khati, Nadia J; Deshmukh, Sandeep P; Dudiak, Kika M; Harisinghani, Mukesh G; Henrichsen, Tara L; Meyer, Benjamin J; Nyberg, David A; Poder, Liina; Shipp, Thomas D; Zelop, Carolyn M; Glanc, Phyllis

2016-12-01

Although there is limited evidence that antepartum testing decreases the risk for fetal death in low-risk pregnancies, women with high-risk factors for stillbirth should undergo antenatal fetal surveillance. The strongest evidence supporting antepartum testing pertains to pregnancies complicated by intrauterine fetal growth restriction secondary to uteroplacental insufficiency. The main ultrasound-based modalities to determine fetal health are the biophysical profile, modified biophysical profile, and duplex Doppler velocimetry. In patients at risk for cardiovascular compromise, fetal echocardiography may also be indicated to ensure fetal well-being. Although no single antenatal test has been shown to be superior, all have high negative predictive values. Weekly or twice-weekly fetal testing has become the standard practice in high-risk pregnancies. The timing for the initiation of assessments of fetal well-being should be tailored on the basis of the risk for stillbirth and the likelihood of survival with intervention. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (the RAND/UCLA Appropriateness Method and the Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances in which evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Variación de la estructura fina de las fibras acrílicas en la hilatura

OpenAIRE

Gacén Guillén, Joaquín; Maillo Garrido, Josefina; Manich i Bou, Albert Mª; Ussmane, Mahomed

2002-01-01

Dos fibras acrílicas comerciales de diferente finura han sido transformadas en hilados en continua de hilar (3.3. dtex) y en hilatura de rotor (1.3 dtex). Los hilos resultantes han sido vaporizados y teñidos en condiciones standard. Las variaciones de la estructura producidas por las operaciones de hilatura, vaporizado y tintura han sido evaluadas a través del ensayo de solubilidad de las fibras acrílicas en una mezcla dimetilformamida/agua (95/5). Two commercial acrylic fibres of d...

Soil carbon sequestration potential in semi-arid grasslands in the conservation reserve program

Science.gov (United States)

The Conservation Reserve Program (CRP) in the USA plays a major role in carbon (C) sequestration to help mitigate rising CO2 levels and climate change. The Southern High Plains (SHP) region contains N900.000 ha enrolled in CRP, but a regionally specific C sequestration rate has not been studied, and...

(S-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu-ACR-16 receptor

Directory of Open Access Journals (Sweden)

Fudan Zheng

2017-04-01

Here, we describe the synthesis of a novel agonist, (S-5-ethynyl-anabasine, and show that it is more potent (EC50 0.14 ± 0.01 μM than other nicotine alkaloids on Asu-ACR-16. Agonists acting on ACR-16 receptors have the potential to circumvent drug resistance to anthelmintics, like levamisole, that do not act on the ACR-16 receptors.

78 FR 1301 - Fiscal Year 2012 Public Transportation on Indian Reservations Program Project Selections

Science.gov (United States)

2013-01-08

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Fiscal Year 2012 Public Transportation... Affairs (BIA) in the U.S. Department of the Interior for public transportation. An additional $500,000 is... Fiscal Year 2013 Public Transportation on Indian Reservations Program, which: (1) Introduces FTA's...

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2

Directory of Open Access Journals (Sweden)

Babu A. Manjasetty

2016-06-01

Full Text Available The fluorescence-based thermal shift (FTS data presented here include Table S1 and Fig. S1, and are supplemental to our original research article describing detailed structural, FTS, and fluorescence polarization analyses of the Salmonella enterica subsp. entrica serovar Typhimurium str. LT2 multidrug transcriptional regulator AcrR (StAcrR (doi:10.1016/j.jsb.2016.01.008 (Manjasetty et al., 2015 [1]. Table S1 contains chemical formulas, a Chemical Abstracts Service (CAS Registry Number (CAS no., FTS rank (a ligand with the highest rank has the largest difference in the melting temperature (ΔTm, and uses as drug molecules against various pathological conditions of sixteen small-molecule ligands that increase thermal stability of StAcrR. Thermal stability of human enolase 1, a negative control protein, was not affected in the presence of various concentrations of the top six StAcrR binders (Fig. S1.

SU-F-R-30: Interscanner Variability of Radiomics Features in Computed Tomography (CT) Using a Standard ACR Phantom

Energy Technology Data Exchange (ETDEWEB)

Shafiq ul Hassan, M; Zhang, G; Moros, E [H Lee Moffitt Cancer Center and Research Institute, Tampa, FL (United States); Department of Physics, University of South Florida, Tampa, FL (United States); Budzevich, M; Latifi, K; Hunt, D; Gillies, R [H Lee Moffitt Cancer Center and Research Institute, Tampa, FL (United States)

2016-06-15

Purpose: A simple approach to investigate Interscanner variability of Radiomics features in computed tomography (CT) using a standard ACR phantom. Methods: The standard ACR phantom was scanned on CT scanners from three different manufacturers. Scanning parameters of 120 KVp, 200 mA were used while slice thickness of 3.0 mm on two scanners and 3.27 mm on third scanner was used. Three spherical regions of interest (ROI) from water, medium density and high density inserts were contoured. Ninety four Radiomics features were extracted using an in-house program. These features include shape (11), intensity (22), GLCM (26), GLZSM (11), RLM (11), and NGTDM (5) and 8 fractal dimensions features. To evaluate the Interscanner variability across three scanners, a coefficient of variation (COV) is calculated for each feature group. Each group is further classified according to the COV- by calculating the percentage of features in each of the following categories: COV less than 2%, between 2 and 10% and greater than 10%. Results: For all feature groups, similar trend was observed for three different inserts. Shape features were the most robust for all scanners as expected. 70% of the shape features had COV <2%. For intensity feature group, 2% COV varied from 9 to 32% for three scanners. All features in four groups GLCM, GLZSM, RLM and NGTDM were found to have Interscanner variability ≥2%. The fractal dimensions dependence for medium and high density inserts were similar while it was different for water inserts. Conclusion: We concluded that even for similar scanning conditions, Interscanner variability across different scanners was significant. The texture features based on GLCM, GLZSM, RLM and NGTDM are highly scanner dependent. Since the inserts of the ACR Phantom are not heterogeneous in HU values suggests that matrix based 2nd order features are highly affected by variation in noise. Research partly funded by NIH/NCI R01CA190105-01.

Resource Management Plan for the Oak Ridge Reservation: Volume 22, Resource information and site analysis for planning on the Oak Ridge Reservation

Energy Technology Data Exchange (ETDEWEB)

Chance, W.W.

1986-12-01

The Department of Energy's (DOE's) Oak Ridge Reservation (ORR) consists of approximately 15,000 ha (37,000 acres) of federally owned lands; it contains three major facilities (Oak Ridge Gaseous Diffusion Plant, Oak Ridge National Laboratory, and the Oak Ridge Y-12 Plant) operated by a single contractor and a number of other facilities operated either by DOE or under contract to others. This report documents the various land use elements, land use constraints (physical, programmatic, and geopolitical), and site potential capabilities and provides current documentation of related data for making land use and site development decisions. The ORR has physical, programmatic, and geopolitical constraints that have been identified, measured, and mapped. The constraints and opportunities map was used to identify developable land areas. Many of these sites have only remote potential for meeting any planned needs for expansion of existing facilities. However, stand-alone research functions or other facilities are possible on these sites. These studied and measured findings lead to the conclusion that extreme care must be taken in the evaluation of future use or disposition of available land. Furthermore, it is time to consider and evaluate the feasibility for renewal. The potential for recycling lands formerly used by programs and functions that have been completed or terminated is very real, considering the age, condition, and obsolescence of these facilities.

75 FR 77658 - Public Land Order No. 7755; Withdrawal of Public Lands and Reserved Federal Minerals for the Ash...

Science.gov (United States)

2010-12-13

... mining laws (30 U.S.C. Ch. 2), and jurisdiction is transferred to the U.S. Fish and Wildlife Service for... mining laws, and 5,570.02 acres of reserved Federal minerals from location under the mining laws, subject.... This order also transfers jurisdiction of the public lands within the Ash Meadows National Wildlife...

A stochastic security approach to energy and spinning reserve scheduling considering demand response program

International Nuclear Information System (INIS)

Partovi, Farzad; Nikzad, Mehdi; Mozafari, Babak; Ranjbar, Ali Mohamad

2011-01-01

In this paper a new algorithm for allocating energy and determining the optimum amount of network active power reserve capacity and the share of generating units and demand side contribution in providing reserve capacity requirements for day-ahead market is presented. In the proposed method, the optimum amount of reserve requirement is determined based on network security set by operator. In this regard, Expected Load Not Supplied (ELNS) is used to evaluate system security in each hour. The proposed method has been implemented over the IEEE 24-bus test system and the results are compared with a deterministic security approach, which considers certain and fixed amount of reserve capacity in each hour. This comparison is done from economic and technical points of view. The promising results show the effectiveness of the proposed model which is formulated as mixed integer linear programming (MILP) and solved by GAMS software. -- Highlights: → Determination of optimal spinning reserve capacity requirement in order to satisfy desired security level set by system operator based on stochastic approach. → Scheduling energy and spinning reserve markets simultaneously. → Comparing the stochastic approach with deterministic approach to determine the advantages and disadvantages of each. → Examine the effect of demand response participation in reserve market to provide spinning reserve.

Summary of the landfill remediation problems and technology needs of the Oak Ridge Reservation Environmental Restoration Programs

International Nuclear Information System (INIS)

1991-01-01

This report discusses the following topics: brief description of the Oak Ridge Reservation Environmental Restoration Program; descriptions of representative waste burials at each site; ongoing, planned, or potential remediation; known or anticipated remediation problems; potential applications for robotics in the remediation of Oak Ridge Reservation landfills

Oak Ridge Reservation Federal Facility Agreement for the Environmental Restoration Program. Volume 1, Quarterly report, October--December 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-01-01

This Oak Ridge Reservation Federal Facility Agreement Quarterly Report for the Environmental Restoration Program was prepared to satisfy requirements for progress reporting on Environmental Restoration Program (ER) activities as specified in the Oak Ridge Reservation Federal Facility Agreement (FFA) established between the US Department of Energy (DOE), the US Environmental Protection Agency, and the Tennessee Department of Environment and Conservation. The reporting period covered in this document is October through December 1995. This work was performed under Work Breakdown Structure 1.4.12.2.3.04 (Activity Data Sheet 8304). Publication of this document meets two FFA milestones. The FFA Quarterly Report meets an FFA milestone defined as 30 days following the end of the applicable reporting period. Appendix A of this report meets the FFA milestone for the Annual Removal Action Report for the period FYs 1991--95. This document provides information about ER Program activities conducted on the Oak Ridge Reservation under the FFA. Specifically, it includes information on milestones scheduled for completion during the reporting period, as well as scheduled for completion during the next reporting period (quarter); accomplishments of the ER Program; concerns related to program work; and scheduled activities for the next quarter. It also provides a listing of the identity and assigned tasks of contractors performing ER Program work under the FFA.

Crystallization and preliminary crystallographic characterization of LmACR2, an arsenate/antimonate reductase from Leishmania major

Energy Technology Data Exchange (ETDEWEB)

Bisacchi, Davide [Bioinformatics and Structural Proteomics, IST-National Cancer Research Institute, Genova (Italy); Zhou, Yao; Rosen, Barry P.; Mukhopadhyay, Rita [Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan (United States); Bordo, Domenico, E-mail: domenico.bordo@istge.it [Bioinformatics and Structural Proteomics, IST-National Cancer Research Institute, Genova (Italy)

2006-10-01

LmACR2 from L. major is the first rhodanese-like enzyme directly involved in the reduction of arsenate and antimonate to be crystallized. Diffraction data have been collected to 1.99 Å resolution using synchrotron X-rays. Arsenic is present in the biosphere owing either to the presence of pesticides and herbicides used in agricultural and industrial activities or to leaching from geological formations. The health effects of prolonged exposure to arsenic can be devastating and may lead to various forms of cancer. Antimony(V), which is chemically very similar to arsenic, is used instead in the treatment of leishmaniasis, an infection caused by the protozoan parasite Leishmania sp.; the reduction of pentavalent antimony contained in the drug Pentostam to the active trivalent form arises from the presence in the Leishmania genome of a gene, LmACR2, coding for the protein LmACR2 (14.5 kDa, 127 amino acids) that displays weak but significant sequence similarity to the catalytic domain of Cdc25 phosphatase and to rhodanese enzymes. For structural characterization, LmACR2 was overexpressed, purified to homogeneity and crystallized in a trigonal space group (P321 or P3{sub 1}21/P3{sub 2}21). The protein crystallized in two distinct trigonal crystal forms, with unit-cell parameters a = b = 111.0, c = 86.1 Å and a = b = 111.0, c = 175.6 Å, respectively. At a synchrotron beamline, the diffraction pattern extended to a resolution limit of 1.99 Å.

Crystallization and preliminary crystallographic characterization of LmACR2, an arsenate/antimonate reductase from Leishmania major

International Nuclear Information System (INIS)

Bisacchi, Davide; Zhou, Yao; Rosen, Barry P.; Mukhopadhyay, Rita; Bordo, Domenico

2006-01-01

LmACR2 from L. major is the first rhodanese-like enzyme directly involved in the reduction of arsenate and antimonate to be crystallized. Diffraction data have been collected to 1.99 Å resolution using synchrotron X-rays. Arsenic is present in the biosphere owing either to the presence of pesticides and herbicides used in agricultural and industrial activities or to leaching from geological formations. The health effects of prolonged exposure to arsenic can be devastating and may lead to various forms of cancer. Antimony(V), which is chemically very similar to arsenic, is used instead in the treatment of leishmaniasis, an infection caused by the protozoan parasite Leishmania sp.; the reduction of pentavalent antimony contained in the drug Pentostam to the active trivalent form arises from the presence in the Leishmania genome of a gene, LmACR2, coding for the protein LmACR2 (14.5 kDa, 127 amino acids) that displays weak but significant sequence similarity to the catalytic domain of Cdc25 phosphatase and to rhodanese enzymes. For structural characterization, LmACR2 was overexpressed, purified to homogeneity and crystallized in a trigonal space group (P321 or P3 1 21/P3 2 21). The protein crystallized in two distinct trigonal crystal forms, with unit-cell parameters a = b = 111.0, c = 86.1 Å and a = b = 111.0, c = 175.6 Å, respectively. At a synchrotron beamline, the diffraction pattern extended to a resolution limit of 1.99 Å

76 FR 14376 - Evaluation of State Coastal Management Programs and National Estuarine Research Reserves

Science.gov (United States)

2011-03-16

... Reserve final management plan approved by the Secretary of Commerce, and adhered to the terms of financial... Program document approved by the Secretary of Commerce, and adhered to the terms of financial assistance awards funded under the CZMA. Each evaluation will include a site visit, consideration of public comments...

Parasitóides (Hymenoptera: Braconidae de Anastrepha Schiner (Diptera: Tephritidae no estado do Acre Parasitoids (Hymenoptera: Braconidae of Anastrepha Schiner (Diptera: Tephritidae in the state of Acre, Brazil

Directory of Open Access Journals (Sweden)

Marcílio José Thomazini

2009-03-01

Full Text Available Este trabalho relata a primeira ocorrência de parasitóides em moscas-das-frutas do gênero Anastrepha Schiner no estado do Acre. No município de Bujari foram encontrados os braconídeos Opius bellus Gahan (72,5%, Doryctobracon areolatus (Szépligeti (26,8% e Utetes anastrephae (Viereck (0,7% associados a A. obliqua (Macquart em frutos de taperebá (Spondias mombin L., com parasitismo de 29,5%. No município de Rio Branco, em frutos de goiaba (Psidium guajava L., ocorreu somente D. areolatus em A. obliqua com parasitismo de 2,7%.This paper records the first parasitoids occurrence on Anastrepha Schiner fruit flies in the state of Acre, Brazil. In the Bujari County there occurred the braconids Opius bellus Gahan (72.5%, Doryctobracon areolatus (Szépligeti (26.8% e Utetes anastrephae (Viereck (0.7% associated with A. obliqua (Macquart in tapereba fruits (Spondias mombin L., with parasitism of 29.5%. In guajava fruits (Psidium guajava L. at Rio Branco County, only D. areolatus on A. obliqua occurred, with parasitism of 2.7%.

NASA LANGLEY RESEARCH CENTER AND THE TIDEWATER INTERAGENCY POLLUTION PREVENTION PROGRAM

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National Aeronautics and Space Administration (NASA)'s Langley Research Center (LaRC) is an 807-acre research center devoted to aeronautics and space research. aRC has initiated a broad-based pollution prevention program guided by a Pollution Prevention Program Plan and implement...

7 CFR 1467.9 - Wetlands Reserve Enhancement Program.

Science.gov (United States)

2010-01-01

..., restoration, and enhancement objectives through agreements with States (including a political subdivision or... project. (b) Reserved Rights Pilot. (1) The Chief shall carry out a reserved rights pilot subject to the requirements established in this part. (2) Under the reserved rights pilot, a landowner may reserve grazing...

Work-Related Injuries of Radiologists and Possible Ergonomic Solutions: Recommendations From the ACR Commission on Human Resources.

Science.gov (United States)

Sze, Gordon; Bluth, Edward I; Bender, Claire E; Parikh, Jay R

2017-10-01

Increasingly, radiologists' workplaces revolve around PACS and digital imaging. Use of these technologies can lead to repetitive strain injuries, many of which can be exacerbated by specific features of a radiology practice environment. Ergonomic approaches, such as proper reading room structure, lighting, temperature, noise, and equipment setup, can help decrease the frequency and severity of repetitive strain injuries and improve radiologist productivity. However, ergonomic approaches are complex, include all aspects of the radiology practice environment, and are best implemented along with proper training of the practicing radiologists. The ergonomic approaches considered most important by members of the ACR Commission on Human Resources are presented in this report, and this information may serve as an aid in departmental planning. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Molecular detection of genes encoding AcrAB , Qep A efflux pumps in Klebsiella pneumoniae strains isolated from hospitalized patients in selected hospitals in Tehran

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Mohsen Heidary

2017-03-01

Full Text Available Abstract Background and Objectives: Increasing emergence of fluoroquinolone resistance among clinical isolates of Klebsiella pneumoniae  (K. pneumoniae, has limited the treatment options for treatment of infections caused by these bacteria. The aim of this study was to investigate the dissemination of genes encoding AcrAB and QepA efflux pumps among K. pneumoniae strains. Methods: This study was carried out on 117 K. pneumoniae strains isolated from patients hospitalized in selected hospitals in Tehran city, 2015-2016, Iran. Antimicrobial susceptibility tests were performed using disk diffusion method (based on CLSI guidelines and identification of acr A, acr B and qep A genes using PCR assay. Results: In this study, colistin and tigecycline had the best effect against clinical isolates of K. pneumoniae. According to PCR results, 110 (94% isolates had acrA gene and 102 (87% isolates had acrB gene, respectively. The qepA gene was not found in any of the K. pneumoniae strains. Conclusion: According to the results of the present study, dissemination of the genes encoding AcrAB efflux pumps among K. pneumoniae strains, which cause resistance to fluoroquinolones, is a matter of concern. Therefore, infection control and prevention of the spread of drug-resistant bacteria requires careful management in drug prescription and identification of resistant isolates.

Amphibia, Anura, Microhylidae, Chiasmocleis avilapiresae Peloso and Sturaro, 2008: First record from the state of Acre, southwestern Amazonia, Brazil

Directory of Open Access Journals (Sweden)

Sampaio, P. R. M.

2010-01-01

Full Text Available We record for the first time the presence of Chiasmocleis avilapiresae in the state of Acre, Brazil. This microhylidfrog is found throughout Amazon in Brazil and no information about its distribution in the Acre state was reported previously.An increase on sampling efforts, revision of material housed in herpetological collections, and use of diverse herpetofaunasampling methods might reveal additional localities and more information about this species.

Amphibia, Anura, Microhylidae, Chiasmocleis avilapiresae Peloso and Sturaro, 2008: first record for the state of Acre, southwestern Amazonia, Brazil

OpenAIRE

Sampaio, Paulo; da Silva, Talisson; Peloso, Pedro

2016-01-01

We record for the first time the presence of Chiasmocleis avilapiresae in the state of Acre, Brazil. This microhylid frog is found throughout Amazon in Brazil and no information about its distribution in the Acre state was reported previously. An increase on sampling efforts, revision of material housed in herpetological collections, and use of diverse herpetofauna sampling methods might reveal additional localities and more information about this species.

Bikeability and methodological issues using the active commuting route environment scale (ACRES in a metropolitan setting

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Schantz Peter

2011-01-01

Full Text Available Abstract Background Route environments can positively influence people's active commuting and thereby contribute to public health. The Active Commuting Route Environment Scale (ACRES was developed to study active commuters' perceptions of their route environments. However, bicycle commuters represent a small portion of the population in many cities and thus are difficult to study using population-based material. Therefore, the aim of this study is to expand the state of knowledge concerning the criterion-related validity of the ACRES and the representativity using an advertisement-recruited sample. Furthermore, by comparing commuting route environment profiles of inner urban and suburban areas, we provide a novel basis for understanding the relationship between environment and bikeability. Methods Bicycle commuters from Greater Stockholm, Sweden, advertisement- (n = 1379 and street-recruited (n = 93, responded to the ACRES. Traffic planning and environmental experts from the Municipality of Stockholm (n = 24 responded to a modified version of the ACRES. The criterion-related validity assessments were based on whether or not differences between the inner urban and the suburban route environments, as indicated by the experts and by four existing objective measurements, were reflected by differences in perceptions of these environments. Comparisons of ratings between advertisement- and street-recruited participants were used for the assessments of representativity. Finally, ratings of inner urban and suburban route environments were used to evaluate commuting route environment profiles. Results Differences in ratings of the inner urban and suburban route environments by the advertisement-recruited participants were in accord with the existing objective measurements and corresponded reasonably well with those of the experts. Overall, there was a reasonably good correspondence between the advertisement- and street-recruited participants' ratings

Bikeability and methodological issues using the active commuting route environment scale (ACRES) in a metropolitan setting.

Science.gov (United States)

Wahlgren, Lina; Schantz, Peter

2011-01-17

Route environments can positively influence people's active commuting and thereby contribute to public health. The Active Commuting Route Environment Scale (ACRES) was developed to study active commuters' perceptions of their route environments. However, bicycle commuters represent a small portion of the population in many cities and thus are difficult to study using population-based material. Therefore, the aim of this study is to expand the state of knowledge concerning the criterion-related validity of the ACRES and the representativity using an advertisement-recruited sample. Furthermore, by comparing commuting route environment profiles of inner urban and suburban areas, we provide a novel basis for understanding the relationship between environment and bikeability. Bicycle commuters from Greater Stockholm, Sweden, advertisement- (n = 1379) and street-recruited (n = 93), responded to the ACRES. Traffic planning and environmental experts from the Municipality of Stockholm (n = 24) responded to a modified version of the ACRES. The criterion-related validity assessments were based on whether or not differences between the inner urban and the suburban route environments, as indicated by the experts and by four existing objective measurements, were reflected by differences in perceptions of these environments. Comparisons of ratings between advertisement- and street-recruited participants were used for the assessments of representativity. Finally, ratings of inner urban and suburban route environments were used to evaluate commuting route environment profiles. Differences in ratings of the inner urban and suburban route environments by the advertisement-recruited participants were in accord with the existing objective measurements and corresponded reasonably well with those of the experts. Overall, there was a reasonably good correspondence between the advertisement- and street-recruited participants' ratings. Distinct differences in commuting route environment

Water Reserves Program. An adaptation strategy to prevent imbalance of water in nature

Science.gov (United States)

Salinas-Rodriguez, S. A.; López Pérez, M.; Barrios Ordóñez, J.; Wickel, B.; Villón Bracamonte, R. A.

2013-12-01

Freshwater ecosystems occupy approximately 1% of the earth's surface yet possess about 12% of all known animal species. By virtue of their position in the landscape they connect terrestrial and coastal marine biomes and provide and sustain ecosystem services vital to the health and persistence of human communities. These services include the supply of water for food production, urban and industrial consumption, among others. Over the past century many freshwater ecosystems around the world have been heavily modified or lost due to the alteration of flow regimes (e.g. damming, canalization, diversion, over-abstraction). The synergistic impacts of land use change, changes in flows, chemical deterioration, and climate change have left many systems and their species very little room to adjust to change, while future projections indicate a steady increase imbalance in water demand for food and energy production and water supply to suit the needs of a growing world population. In Mexico, the focus has been to secure water for human development and maximize economic growth, which has resulted in allocation of water beyond available amounts, and that in many river basins has led imbalance of water in nature. As a consequence episodic water scarcity severely constrains freshwater ecosystems and the services they provide. Climatic change and variability are presenting serious challenges to a country that already is experiencing serious strain on its water resources. However, freshwater ecosystems are recognized by law as legitimate user of water, and mandate a flow allocation for the environment ('water reserve' or 'environmental flows'). Based on this legal provision the Mexican government through the National Water Commission (Conagua), with support of the Alliance WWF - Fundación Gonzalo Río Arronte, and the Interamerican Development Bank, has launched a national program to identify and implement 'water reserves': basins where environmental flows will be secured and

Switch loop flexibility affects substrate transport of the AcrB efflux pump

International Nuclear Information System (INIS)

Muller, Reinke T.; Travers, Timothy; Cha, Hi-jea; Phillips, Joshua L.

2017-01-01

The functionally important switch-loop of the trimeric multidrug transporter AcrB separates the access and deep drug binding pockets in every protomer. This loop, comprising 11 amino acid residues, has been shown to be crucial for substrate transport, as drugs have to travel past the loop to reach the deep binding pocket and from there are transported outside the cell via the connected AcrA and TolC channels. It contains four symmetrically arranged glycine residues suggesting that flexibility is a key feature for pump activity. Upon combinatorial substitution of these glycine residues to proline, functional and structural asymmetry was observed. Proline substitutions on the PC1 proximal side completely abolished transport and reduced backbone flexibility of the switch loop, which adopted a conformation restricting the pathway towards the deep binding pocket. Here, two phenylalanine residues located adjacent to the substitution sensitive glycine residues play a role in blocking the pathway upon rigidification of the loop, since the removal of the phenyl rings from the rigid loop restores drug transport activity.

24 CFR 572.125 - Replacement reserves.

Science.gov (United States)

2010-04-01

...) Homeownership Program Requirements-Implementation Grants § 572.125 Replacement reserves. (a) Purpose. A single replacement reserve may be established for the homeownership program only if HUD determines it is necessary to... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Replacement reserves. 572.125...

New bidding strategy formulation for day-ahead energy and reserve markets based on evolutionary programming

International Nuclear Information System (INIS)

Attaviriyanupap, Pathom; Kita, Hiroyuki; Tanaka, Eiichi; Hasegawa, Jun

2005-01-01

In this paper, a new bidding strategy for a day-ahead market is formulated. The proposed algorithm is developed from the viewpoint of a generation company wishing to maximize a profit as a participant in the deregulated power and reserve markets. Separate power and reserve markets are considered, both are operated by clearing price auction system. The optimal bidding parameters for both markets are determined by solving an optimization problem that takes unit commitment constraints such as generating limits and unit minimum up/down time constraints into account. This is a non-convex and non-differentiable which is difficult to solve by traditional optimization techniques. In this paper, evolutionary programming is used to solve the problem. The algorithm is applied to both single-sided and double-sided auctions, numerical simulations are carried out to demonstrate the performance of the proposed scheme compared with those obtained from a sequential quadratic programming. (author)

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.

Science.gov (United States)

Eicher, Thomas; Seeger, Markus A; Anselmi, Claudio; Zhou, Wenchang; Brandstätter, Lorenz; Verrey, François; Diederichs, Kay; Faraldo-Gómez, José D; Pos, Klaas M

2014-09-19

Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic development in humans. We use high-resolution X-ray crystallography and computational methods to delineate the mechanism of the homotrimeric RND-type proton/drug antiporter AcrB, the active component of the major efflux system AcrAB-TolC in Escherichia coli, and one most complex and intriguing membrane transporters known to date. Analysis of wildtype AcrB and four functionally-inactive variants reveals an unprecedented mechanism that involves two remote alternating-access conformational cycles within each protomer, namely one for protons in the transmembrane region and another for drugs in the periplasmic domain, 50 Å apart. Each of these cycles entails two distinct types of collective motions of two structural repeats, coupled by flanking α-helices that project from the membrane. Moreover, we rationalize how the cross-talk among protomers across the trimerization interface might lead to a more kinetically efficient efflux system.

Decentralization of operating reactor licensing reviews: NRR Pilot Program

International Nuclear Information System (INIS)

Hannon, J.N.

1984-07-01

This report, which has incorporated comments received from the Commission and ACRS, describes the program for decentralization of selected operating reactor licensing technical review activities. The 2-year pilot program will be reviewed to verify that safety is enhanced as anticipated by the incorporation of prescribed management techniques and application of resources. If the program fails to operate as designed, it will be terminated

Oak Ridge Reservation Site Management Plan for the Environmental Restoration Program

International Nuclear Information System (INIS)

1991-09-01

This site management for the Environmental Restoration (ER) Program implements the Oak Ridge Reservation (ORR) Federal Facility Agreement (FFA) (EPA 1990), also known as an Interagency Agreement (IAG), hereafter referred to as ''the Agreement.'' The Department of Energy (DOE), the US Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC), hereafter known as ''the Parties,'' entered into this Agreement for the purpose of coordinating remediation activities undertaken on the ORR to comply with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) as amended by the Superfund Amendments, the Resource Conservation and Recovery Act (RCRA), and the National Environmental Policy Act (NEPA). 7 refs., 17 figs

Bioinjection Performance Review for the Building 100 Area and 4.5 Acre Site at the Pinellas County, Florida, Site

Energy Technology Data Exchange (ETDEWEB)

Survochak, Scott [US Department of Energy, Washington, DC (United States). Office of Legacy Management; Daniel, Joe [Navarro Research and Engineering, Oak Ridge, TN (United States)

2016-05-01

This document provides a summary of a review of the performance of bioinjection activities at the Building 100 Area and the 4.5 Acre Site at the Pinellas County, Florida, Site since 2010, determines how best to optimize future injection events, and identifies the approach for the bioinjection event in 2016 at (1) the 4.5 Acre Site and (2) the Essentra property at the Building 100 Area. Because this document describes the next bioinjection event at the 4.5 Acre Site, it also serves as an addendum to the Interim Remedial Action Plan for Emulsified Edible Oil Injection at the 4.5 Acre Site (DOE 2013). In addition, this document revises the injection layout and injection intervals for the Essentra property that were originally described in the Interim Corrective Measure Work Plan for Source and Plume Treatment at the Building 100 Area (DOE 2014), and is a de facto update of that document. Bioinjection consists of injection of emulsified vegetable oil (EVO) and the microorganism Dehalococcoides mccartyi (DHM; formerly known as Dehalococcoides ethenogenes) into the subsurface to enhance biodegradation of trichloroethene (TCE), dichloroethene (DCE), and vinyl chloride (VC). VC is the only contaminant that exceeds its maximum contaminant level (10 micrograms per liter onsite and 1 microgram per liter onsite) on the 4.5 Acre Site and the Essentra property. Bioinjection was conducted at the 4.5 Acre Site in 2010 and 2013. Approximately 49,900 gallons of EVO and DHM were injected at 95 injection points in February 2010, and approximately 22,900 gallons of EVO and DHM were injected at 46 injection points in July 2013. The injection locations are shown on Figure 1. The goal of bioinjection at the 4.5 Acre Site is to decrease contaminant concentrations to maximum contaminant levels along the west and southwest property boundaries (to meet risk–based corrective action requirements) and to minimize the extent of the contaminant plume in the interior of the site. Bioinjection was

Gender and the radiology workforce: results of the 2014 ACR workforce survey.

Science.gov (United States)

Bluth, Edward I; Bansal, Swati; Macura, Katarzyna J; Fielding, Julia; Truong, Hang

2015-02-01

As part of the 2014 ACR Human Resources Commission Workforce Survey, an assessment of the gender of the U.S. radiologist workforce was undertaken. Radiologist gender in relation to type of practice, work location, leadership roles, and full- versus part-time employment have not previously been assessed by this survey. The survey was completed by group leaders in radiology identified through the Practice of Radiology Environment Database. The response rate to the survey was 22%, representing 35% of all practicing radiologists. The survey found that 78% of the radiology workforce is male, and 22% female. Among the men, 58% work in private practice, and 18% in the academic/university environment; among women, percentages were 43% and 31%, respectively. Of all physician leads, 85% are men, 15% women. Of the full-time radiologists, 15% of men are practice leaders compared with 11% of women. Fewer women than men are in private practice. More women than men practice in academic/university environments. Among part-time radiologists, there are more men than women, but significantly more women work part time than men. Women are in the minority among practice leaders. Copyright © 2015 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Portal verification using the KODAK ACR 2000 RT storage phosphor plate system and EC films. A semiquantitative comparison.

Science.gov (United States)

Geyer, Peter; Blank, Hilbert; Alheit, Horst

2006-03-01

The suitability of the storage phosphor plate system ACR 2000 RT (Eastman Kodak Corp., Rochester, MN, USA), that is destined for portal verification as well as for portal simulation imaging in radiotherapy, had to be proven by the comparison with a highly sensitive verification film. The comparison included portal verification images of different regions (head and neck, thorax, abdomen, and pelvis) irradiated with 6- and 15-MV photons and electrons. Each portal verification image was done at the storage screen and the EC film as well, using the EC-L cassettes (both: Eastman Kodak Corp., Rochester, MN, USA) for both systems. The soft-tissue and bony contrast and the brightness were evaluated and compared in a ranking of the two compared images. Different phantoms were irradiated to investigate the high- and low-contrast resolution. To account for quality assurance application, the short-time exposure of the unpacked and irradiated storage screen by green and red room lasers was also investigated. In general, the quality of the processed ACR images was slightly higher than that of the films, mostly due to cases of an insufficient exposure to the film. The storage screen was able to verify electron portals even for low electron energies with only minor photon contamination. The laser lines were sharply and clearly visible on the ACR images. The ACR system may replace the film without any noticeable decrease in image quality thereby reducing processing time and saving the costs of films and avoiding incorrect exposures.

Vegetation changes over 12 years in ungrazed and grazed Conservation Reserve Program Grasslands in the central and southern plains

Science.gov (United States)

Cade, Brian S.; Vandever, Mark W.; Allen, Arthur W.; Terrell, James W.

2005-01-01

The Conservation Reserve Program (CRP) established under the 1985 Food Security Act has the fundamental objectives of jointly providing economic support to segments of the agricultural community and conservation of natural resources (Osborn, 1997; Heard and others, 2000). Although soil loss on highly erodable lands was the principal natural resource conservation issue addressed in the 1985 CRP, improving water quality and wildlife habitat both became important considerations as the program evolved (Farmer and others, 1988). For example, Best and others (1997) found that production of young birds on CRP fields in the Midwest was ≥15 times the production on row-crop fields because of improved habitat. The increasing importance of wildlife habitat is reflected in continuing refinement of the Environmental Benefits Index (EBI) used by the U.S. Department of Agriculture (USDA) to quantify the potential benefits of enrolling lands in CRP (Osborn, 1997; Ribaudo and others, 2001). The refinements reflect input furnished by federal, state, and non-government organizations seeking greater wildlife habitat quality on CRP lands (Roseberry and David, 1994; Hughes and others, 1995; Millenbah and others, 1996; Patterson and Best, 1996; Rodgers, 1999; Allen and others, 2001).Refinement in the EBI has changed the types of grasses planted on newly enrolled land. In early CRP signups (1 through 11), 71% of new grassland acres were planted to introduced grasses and legumes [Conservation Practice (CP) 1] while 29% of the acres were planted to native grasses (CP2) (Osborn and others, 1992). By the 27th signup in July 2004, over 34.8 million acres (14 million ha) were enrolled in the CRP. More than 73% of these lands were planted to various mixtures of introduced (CP1) or native (CP2) grasses for a minimal contract period of 10 years (USDA, 2004). Continuation of grass plantings under the 2002 Farm Bill may result in CRP lands furnishing grass dominated cover for 20 or more consecutive

Primeiro registro de Zaprionus indianus Gupta (Diptera: Drosophilidae no Estado do Acre

Directory of Open Access Journals (Sweden)

Adriana Vasconcelos

2017-04-01

Abstract. This work makes reference to the first record of Zaprionus indianus Gupta (Diptera: Drosophilidae found in carambola fruits (Averrhoa carambola L. in a residential yard located in the county of Rio Branco, Acre, Brazil. The emerged flies were preserved in flasks containing 70% alcohol and identified by the characteristics of the anterior left leg and the male’s genitalia.

Em busca de conforto lingüístico e metodológico no Acre indígena In search of linguistic and methodological comfort in indigenous Acre

Directory of Open Access Journals (Sweden)

Terezinha Machado Maher

2008-12-01

Full Text Available Neste texto, pretende-se, em última instância, refletir sobre os modos como as pesquisas são, sempre, condicionadas por representações culturalmente determinadas. Para tanto, considerarei práticas discursivas em um contexto de formação continuada de professores-pesquisadores indígenas no Estado do Acre. Atualmente envolvidos com a condução de pesquisas de cunho sociolingüístico, esses professores esperam produzir conhecimento que os ajudem a formular políticas lingüísticas locais favoráveis ao fortalecimento das línguas tradicionais de suas comunidades de fala. O foco de análise recairá, especificamente, sobre algumas visões conflitantes entre os modos como esses professores e sua formadora não-indígena avaliam instrumentos de pesquisa e entendem como devem se dar os processos de geração de dados. Além de argumentar que a não consideração dessas diferenças de perspectivas podem se constituir em impedimento importante para a condução do tipo de investigação desejada, pretendo, neste texto, chamar a atenção para o fato de que, por um lado, a categoria local precisa ser sempre lida com parcimônia e, por outro, conceitos como etnocentrismo ou grafocentrismo nem sempre são suficientes para explicar todos os complexos problemas de que se investem as relações interculturais. A expectativa é que este texto possa, de alguma maneira, contribuir para a formação de professores-pesquisadores no país e, sobretudo, para a nossa compreensão da complexidade imposta, contemporaneamente, pela interculturalidade.The aim of this paper is to reflect upon the ways research processes are conditioned by culturally determined representations. In order to do so, discursive practices in an in-service indigenous teacher-researcher educational program in the state of Acre will be examined. Presently involved in local sociolinguistic research projects, these teachers hope to produce knowledge that will help them devise linguistic

Oak Ridge Reservation Federal Facility Agreement: Quarterly report for the Environmental Restoration Program. Volume 2, January--March 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

This report provides information about ER Program activities conducted on the Oak Ridge Reservation under the Federal Facility Agreement (FFA). Specifically, it includes information on milestones scheduled for completion during the reporting period as well as scheduled for completion during the next reporting period (quarter), accomplishments of the ER Program, concerns related to program work, and scheduled activities for the next quarter. It also provides a listing of the identity and assigned tasks of contractors performing ER Program work under the FFA.

Role of the pathotype-specific ACRTS1 gene encoding a hydroxylase involved in the biosynthesis of host-selective ACR-toxin in the rough lemon pathotype of Alternaria alternata.

Science.gov (United States)

Izumi, Yuriko; Kamei, Eri; Miyamoto, Yoko; Ohtani, Kouhei; Masunaka, Akira; Fukumoto, Takeshi; Gomi, Kenji; Tada, Yasuomi; Ichimura, Kazuya; Peever, Tobin L; Akimitsu, Kazuya

2012-08-01

The rough lemon pathotype of Alternaria alternata produces host-selective ACR-toxin and causes Alternaria leaf spot disease of the rootstock species rough lemon (Citrus jambhiri) and Rangpur lime (C. limonia). Genes controlling toxin production were localized to a 1.5-Mb chromosome carrying the ACR-toxin biosynthesis gene cluster (ACRT) in the genome of the rough lemon pathotype. A genomic BAC clone containing a portion of the ACRT cluster was sequenced which allowed identification of three open reading frames present only in the genomes of ACR-toxin producing isolates. We studied the functional role of one of these open reading frames, ACRTS1 encoding a putative hydroxylase, in ACR-toxin production by homologous recombination-mediated gene disruption. There are at least three copies of ACRTS1 gene in the genome and disruption of two copies of this gene significantly reduced ACR-toxin production as well as pathogenicity; however, transcription of ACRTS1 and production of ACR-toxin were not completely eliminated due to remaining functional copies of the gene. RNA-silencing was used to knock down the remaining ACRTS1 transcripts to levels undetectable by reverse transcription-polymerase chain reaction. The silenced transformants did not produce detectable ACR-toxin and were not pathogenic. These results indicate that ACRTS1 is an essential gene in ACR-toxin biosynthesis in the rough lemon pathotype of A. alternata and is required for full virulence of this fungus.

Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling.

Science.gov (United States)

Seeger, Markus A; von Ballmoos, Christoph; Verrey, François; Pos, Klaas M

2009-06-30

The three-component AcrA/AcrB/TolC efflux system of Escherichia coli catalyzes the proton motive force-driven extrusion of a variety of cytotoxic compounds. The inner membrane pump component AcrB belongs to the resistance nodulation and cell division (RND) superfamily and is responsible for drug specificity and energy transduction of the entire tripartite efflux system. Systematic mutational analysis of titratable and polar membrane-located amino acids revealed four residues, D407, D408, K940, and, R971, to be of prime importance for AcrB function. Using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry, D408 was shown to specifically react with dicyclohexylcarbodiimide (DCCD) in a pH-dependent manner. The apparent pK(a) of D408 of 7.4 would enable binding and release of protons under physiological conditions. In contrast to other secondary transporters, D408 was not protected from carbodiimide modification in the presence of drugs, which supports the notion of spatially separated transport pathways for drugs and protons. This study provides evidence for a substantial role of membrane-located carboxylates as a central element of the proton translocation pathway in AcrB and other members of the RND superfamily.

Top Textbooks on Reserve: Creating, Promoting, and Assessing a Program to Help Meet Students' Need for Affordable Textbooks

Science.gov (United States)

Thompson, Hilary H.; Cotton, Jennifer E. M.

2017-01-01

In Fall 2014 the University of Maryland Libraries launched a textbook reserves program to help relieve the burden of high textbook costs on students. Although its initial performance was lackluster, workflow refinements and expanded promotion greatly improved usage, resulting in a tenfold increase in circulation and expansion of the program. This…

Oak Ridge Reservation Site Management Plan for the Environmental Restoration Program

Energy Technology Data Exchange (ETDEWEB)

1991-09-01

This site management for the Environmental Restoration (ER) Program implements the Oak Ridge Reservation (ORR) Federal Facility Agreement (FFA) (EPA 1990), also known as an Interagency Agreement (IAG), hereafter referred to as the Agreement.'' The Department of Energy (DOE), the US Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC), hereafter known as the Parties,'' entered into this Agreement for the purpose of coordinating remediation activities undertaken on the ORR to comply with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) as amended by the Superfund Amendments, the Resource Conservation and Recovery Act (RCRA), and the National Environmental Policy Act (NEPA). 7 refs., 17 figs.

Combinations of mutations in envZ, ftsI, mrdA, acrB and acrR can cause high-level carbapenem resistance in Escherichia coli

DEFF Research Database (Denmark)

Adler, Marlen; Anjum, Mehreen; Andersson, Dan I.

2016-01-01

of meropenem or ertapenem for similar to 60 generations. Isolated clones were whole-genome sequenced, and the order in which the identified mutations arose was determined in the passaged populations. Key mutations were reconstructed, and bacterial growth rates of populations and isolated clones and resistance...... levels to 23 antibiotics were measured. High-level resistance to carbapenems resulted from a combination of downstream effects of envZ mutation and target mutations in AcrAB-TolC-mediated drug export, together with PBP genes [mrdA (PBP2) after meropenem exposure or ftsI (PBP3) after ertapenem exposure...

EnviroAtlas - Acres of crops that have no nearby pollinator habitat for the Conterminous United States

Data.gov (United States)

U.S. Environmental Protection Agency — This dataset is a summary of crop acres without nearby pollinator habitat. Pollination habitat here is defined as trees (fruit, nut, deciduous, and evergreen). Crops...

77 FR 36289 - Implementation of Indian Reservation Roads Program and Streamlining the Federal Delivery of...

Science.gov (United States)

2012-06-18

... reauthorization of the current transportation legislation involving the Indian Reservation Roads program or, if new transportation legislation is enacted prior to the meetings, BIA and FHWA will discuss its... Spokane, WA..... 9 a.m.-4:30 p.m. June 12, 2012 Albuquerque, NM. 9 a.m.-4:30 p.m. June 13, 2012 Phoenix...

Design of New Antibacterial Enhancers Based on AcrB’s Structure and the Evaluation of Their Antibacterial Enhancement Activity

Directory of Open Access Journals (Sweden)

Yi Song

2016-11-01

Full Text Available Previously, artesunate (AS and dihydroartemisinine 7 (DHA7 were found to have antibacterial enhancement activity against Escherichia coli via inhibition of the efflux pump AcrB. However, they were only effective against E. coli standard strains. This study aimed to develop effective antibacterial enhancers based on the previous work. Our results demonstrate that 86 new antibacterial enhancers were designed via 3D-SAR and molecular docking. Among them, DHA27 had the best antibacterial enhancement activity. It could potentiate the antibacterial effects of ampicillin against not only E. coli standard strain but also clinical strains, and of β-lactam antibiotics, not non-β-lactamantibiotics. DHA27 could increase the accumulation of daunomycin and nile red within E. coli ATCC 35218, but did not increase the bacterial membrane permeability. DHA27 reduced acrB’s mRNA expression of E. coli ATCC 35218 in a dose-dependent manner, and its antibacterial enhancement activity is related to the degree of acrB mRNA expression in E. coli clinical strains. The polypeptides from AcrB were obtained via molecular docking assay; the pre-incubated polypeptides could inhibit the activity of DHA27. Importantly, DHA27 had no cytotoxicity on cell proliferation. In conclusion, among newly designed antibacterial enhancers, DHA27 had favorable physical and pharmacological properties with no significant cytotoxicity at effective concentrations, and might serve as a potential efflux pump inhibitor in the future.

A Case Study and Analysis of a Successful and Collaborative Student-Centered Textbook Reserve Program in a Mid-Size Academic Library

Science.gov (United States)

Schlak, Timothy M.; Johnston, Bruce

2018-01-01

This article presents an innovative textbook reserve program at a mid-sized academic library. Research conducted subsequent to the program's launch showed a positive correlation between students' use of the program and their perceived academic success. In addition, the program has proved effective at helping students with college affordability.…

TU-F-CAMPUS-I-05: Semi-Automated, Open Source MRI Quality Assurance and Quality Control Program for Multi-Unit Institution

International Nuclear Information System (INIS)

Yung, J; Stefan, W; Reeve, D; Stafford, RJ

2015-01-01

Purpose: Phantom measurements allow for the performance of magnetic resonance (MR) systems to be evaluated. Association of Physicists in Medicine (AAPM) Report No. 100 Acceptance Testing and Quality Assurance Procedures for MR Imaging Facilities, American College of Radiology (ACR) MR Accreditation Program MR phantom testing, and ACR MRI quality control (QC) program documents help to outline specific tests for establishing system performance baselines as well as system stability over time. Analyzing and processing tests from multiple systems can be time-consuming for medical physicists. Besides determining whether tests are within predetermined limits or criteria, monitoring longitudinal trends can also help prevent costly downtime of systems during clinical operation. In this work, a semi-automated QC program was developed to analyze and record measurements in a database that allowed for easy access to historical data. Methods: Image analysis was performed on 27 different MR systems of 1.5T and 3.0T field strengths from GE and Siemens manufacturers. Recommended measurements involved the ACR MRI Accreditation Phantom, spherical homogenous phantoms, and a phantom with an uniform hole pattern. Measurements assessed geometric accuracy and linearity, position accuracy, image uniformity, signal, noise, ghosting, transmit gain, center frequency, and magnetic field drift. The program was designed with open source tools, employing Linux, Apache, MySQL database and Python programming language for the front and backend. Results: Processing time for each image is <2 seconds. Figures are produced to show regions of interests (ROIs) for analysis. Historical data can be reviewed to compare previous year data and to inspect for trends. Conclusion: A MRI quality assurance and QC program is necessary for maintaining high quality, ACR MRI Accredited MR programs. A reviewable database of phantom measurements assists medical physicists with processing and monitoring of large datasets

TU-F-CAMPUS-I-05: Semi-Automated, Open Source MRI Quality Assurance and Quality Control Program for Multi-Unit Institution

Energy Technology Data Exchange (ETDEWEB)

Yung, J; Stefan, W; Reeve, D; Stafford, RJ [UT MD Anderson Cancer Center, Houston, TX (United States)

2015-06-15

Purpose: Phantom measurements allow for the performance of magnetic resonance (MR) systems to be evaluated. Association of Physicists in Medicine (AAPM) Report No. 100 Acceptance Testing and Quality Assurance Procedures for MR Imaging Facilities, American College of Radiology (ACR) MR Accreditation Program MR phantom testing, and ACR MRI quality control (QC) program documents help to outline specific tests for establishing system performance baselines as well as system stability over time. Analyzing and processing tests from multiple systems can be time-consuming for medical physicists. Besides determining whether tests are within predetermined limits or criteria, monitoring longitudinal trends can also help prevent costly downtime of systems during clinical operation. In this work, a semi-automated QC program was developed to analyze and record measurements in a database that allowed for easy access to historical data. Methods: Image analysis was performed on 27 different MR systems of 1.5T and 3.0T field strengths from GE and Siemens manufacturers. Recommended measurements involved the ACR MRI Accreditation Phantom, spherical homogenous phantoms, and a phantom with an uniform hole pattern. Measurements assessed geometric accuracy and linearity, position accuracy, image uniformity, signal, noise, ghosting, transmit gain, center frequency, and magnetic field drift. The program was designed with open source tools, employing Linux, Apache, MySQL database and Python programming language for the front and backend. Results: Processing time for each image is <2 seconds. Figures are produced to show regions of interests (ROIs) for analysis. Historical data can be reviewed to compare previous year data and to inspect for trends. Conclusion: A MRI quality assurance and QC program is necessary for maintaining high quality, ACR MRI Accredited MR programs. A reviewable database of phantom measurements assists medical physicists with processing and monitoring of large datasets

EL ACRE Y LOS "ASUNTOS DEL PACÍFICO: BOLIVIA, BRASIL, CHILE Y ESTADOS UNIDOS, 1898-1909

Directory of Open Access Journals (Sweden)

Cristián Garay Vera

2008-12-01

Full Text Available Este trabajo sitúa el problema de la guerra del Acre en un contexto multilateral, reconociendo la vigencia del equilibrio de poder como parte del razonamiento de la conducción de las políticas exteriores en juego. Se aplica el concepto de frontera de F. J. Turner, para explicar cómo las fronteras permeables pusieron a Brasil y Bolivia en confrontación, por la maniobra boliviana de configurar una concesión a inversionistas estadounidenses, británicos y franceses, que fue interpretada por Brasil como una maniobra imperialista de Estados Unidos. Entones Brasil se acercó a Chile, y afrontaron juntos los problemas del Acre y de Antofagasta, que derivaron en las redacciones de los tratados de Petrópolis (1903 y de Paz y Amistad (1904. El artículo postula que Bolivia procedió de esta forma para impedir el avance brasileño, peruano y paraguayo sobre sus fronteras, y que la búsqueda del paraguas estadounidense fue una idea que Bolivia gestó para compensar el desequilibrio de poder.This work considers the Acre War as part of a multilateral context where the equilibrium of power was important in the reasoning behind the establishment of foreign relations. It uses the frontier concept developed by F. J. Turner to explain why their open frontier put Brazil and Bolivia in confrontation. This happened because of the Bolivian strategy of granting land to investors from the United States, Great Britain and France, which was interpreted by Brazil as an imperialist action promoted by the United States. This explains why Brazil established a cióse relationship with Chile to confront together their problems in Acre and Antofagasta, which led to the drafting of the Petrópilis (1903 and Paz y Amistad (1904 treaties. The article argues that Bolivia proceeded this way to avoid a Brazilian, Peruvian or Paraguayan territorial advance, seeking the support of the United States to compénsate the imbalance of power.

Trypanosoma sp. diversity in Amazonian bats (Chiroptera; Mammalia) from Acre State, Brazil.

Science.gov (United States)

Dos Santos, Francisco C B; Lisboa, Cristiane V; Xavier, Samanta C C; Dario, Maria A; Verde, Rair de S; Calouro, Armando M; Roque, André Luiz R; Jansen, Ana M

2017-11-16

Bats are ancient hosts of Trypanosoma species and their flying ability, longevity and adaptability to distinct environments indicate that they are efficient dispersers of parasites. Bats from Acre state (Amazon Biome) were collected in four expeditions conducted in an urban forest (Parque Zoobotânico) and one relatively more preserved area (Seringal Cahoeira) in Rio Branco and Xapuri municipalities. Trypanosoma sp. infection was detected by hemoculture and fresh blood examination. Isolated parasite species were identified by the similarity of the obtained DNA sequence from 18S rDNA polymerase chain reaction and reference strains. Overall, 367 bats from 23 genera and 32 species were examined. Chiropterofauna composition was specific to each municipality, although Artibeus sp. and Carollia sp. prevailed throughout. Trypanosoma sp. infection was detected in 85 bats (23·2%). The most widely distributed and prevalent genotypes were (in order) Trypanosoma cruzi TcI, T. cruzi marinkellei, Trypanosoma dionisii, T. cruzi TcIV and Trypanosoma rangeli. At least one still-undescribed Trypanosoma species was also detected in this study. The detection of T. cruzi TcI and TcIV (the ones associated with Chagas disease in Amazon biome) demonstrates the putative importance of these mammal hosts in the epidemiology of the disease in the Acre State.

Comparative analysis of the 2016 ACR-EULAR and the 2002 AECG classification criteria for Sjögren's syndrome: Findings from the NIH cohort.

Science.gov (United States)

Billings, M; Amin Hadavand, M; Alevizos, I

2018-03-01

The introduction of new classification criteria for Sjögren's syndrome, known as the 2016 American College of Rheumatology/European League against Rheumatism Classification Criteria (ACR-EULAR), created a need for the evaluation of its performance in an external cohort. The purpose of this study was to compare the performance of the 2016 ACR-EULAR classification set with the widely used American-European Consensus Group Classification criteria (AECG) in the cohort at the National Institutes of Health, USA, and to compare the performance of the sets in classifying both primary and secondary Sjögren's syndrome (pSS and sSS). The study cohort at the NIH (N = 1,303) was enrolled for clinical suspicion of SS. Participants were classified as SS, pSS, and sSS according to both classification sets. Performance of 2016 ACR-EULAR and AECG sets was compared holding each as gold standard to the other. Statistical analysis of test diagnostics and agreement between the two sets were undertaken. By the AECG set, 701 were classified as having SS (627 pSS, 74 sSS) and 714 were classified with SS (647 pSS, 67 sSS) by the 2016 ACR-EULAR set. Sensitivity and specificity of the two sets were comparable in classifying SS, pSS, and sSS. There was high agreement between the two sets for classifying SS (κ = 0.79), pSS (κ = 0.81), and sSS (κ = 0.87). The specificity of the 2016 ACR-EULAR set was significantly higher for classifying sSS than pSS, while the sensitivity was similar for the two disease groups. However, this pattern was also exhibited by the AECG set. There was high agreement between the two classification sets with comparable performance diagnostics. There was no evidence of superior performance value by the new 2016 ACR-EULAR set over the AECG set, and the two sets were found to be equivalent. Findings from our cohort indicate that 2016 ACR-EULAR classification could be extended to classification of sSS. Published 2018. This article is a U.S. Government work and

48 CFR 19.801 - [Reserved

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false [Reserved] 19.801 Section 19.801 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19.801...

Joint involvement in patients with early polymyalgia rheumatica using high-resolution ultrasound and its contribution to the EULAR/ACR 2012 classification criteria for polymyalgia rheumatica.

Science.gov (United States)

Weigand, Sandra; Ehrenstein, Boris; Fleck, Martin; Hartung, Wolfgang

2014-04-01

To assess joint involvement and the contribution of musculoskeletal ultrasound (MSUS) to the novel European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) 2012 classification criteria in patients with polymyalgia rheumatic (PMR). MSUS was performed in 54 consecutive patients with recent-onset PMR. Biceps tenosynovitis of at least 1 shoulder has been observed in 70.4% of patients, and 64.8% had a bilateral biceps tenosynovitis. Subdeltoid bursitis (27.8% unilateral, 5.6% bilateral), glenohumeral synovitis (22.2% unilateral, 9.3% bilateral), and hip involvement (22.2% unilateral, 16.7% bilateral) were observed less frequently. The sensitivities of the classification criteria were 85.2% for EULAR/ACR without MSUS and 81.5% for EULAR/ACR with MSUS. The most common MSUS pathology was a biceps tenosynovitis. However, US findings had no effect on the sensitivity of the novel EULAR/ACR criteria for PMR.

Research and development program, fiscal year 1974

Energy Technology Data Exchange (ETDEWEB)

1972-04-01

The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for Fiscal Year 1974 is conducted within the scope of the following categories: Effects of Radiation of Living Organisms; Molecular and Cellular Radiobiology; Land and Fresh Water Environmental Sciences; Radiological and Health Physics and Instrumentation; and Nuclear Medical Research. (ACR)

First record of Ceratitis capitata (Wiedemann (Diptera: Tephritidae in the state of Acre, Brazil

Directory of Open Access Journals (Sweden)

Ricardo Adaime

2017-12-01

Resumo. Registra-se pela primeira vez a presença de Ceratitis capitata (Wiedemann (Diptera: Tephritidae no estado do Acre, Brasil, a partir de frutos de goiabeira (Psidium guajava L. e de caramboleira (Averrhoacarambola L., aumentando o conhecimento dos registros geográficos dessa mosca na Amazônia brasileira.

Portal verification using the KODAK ACR 2000 RT storage phosphor plate system and EC registered films. A semiquantitative comparison

International Nuclear Information System (INIS)

Geyer, P.; Blank, H.; Alheit, H.

2006-01-01

Background and Purpose: the suitability of the storage phosphor plate system ACR 2000 RT (Eastman Kodak Corp., Rochester, MN, USA), that is destined for portal verification as well as for portal simulation imaging in radiotherapy, had to be proven by the comparison with a highly sensitive verification film. Material and Methods: the comparison included portal verification images of different regions (head and neck, thorax, abdomen, and pelvis) irradiated with 6- and 15-MV photons and electrons. Each portal verification image was done at the storage screen and the EC registered film as well, using the EC-L registered cassettes (both: Eastman Kodak Corp., Rochester, MN, USA) for both systems. The soft-tissue and bony contrast and the brightness were evaluated and compared in a ranking of the two compared images. Different phantoms were irradiated to investigate the high- and low-contrast resolution. To account for quality assurance application, the short-time exposure of the unpacked and irradiated storage screen by green and red room lasers was also investigated. Results: in general, the quality of the processed ACR images was slightly higher than that of the films, mostly due to cases of an insufficient exposure to the film. The storage screen was able to verify electron portals even for low electron energies with only minor photon contamination. The laser lines were sharply and clearly visible on the ACR images. Conclusion: the ACR system may replace the film without any noticeable decrease in image quality thereby reducing processing time and saving the costs of films and avoiding incorrect exposures. (orig.)

Avaliação da concentração de mercúrio em sedimentos e material particulado no rio Acre, estado do Acre, Brasil Mercury concentration assessment in botton sediments and suspended solids from Acre river, in the State of Acre, Brazil

Directory of Open Access Journals (Sweden)

Artur Fernando Silva Mascarenhas

2004-01-01

Full Text Available A avaliação dos teores de mercúrio em sistemas aquáticos sem influência direta de fontes antropogênicas conhecidas não tem sido conduzida com freqüência na região Amazônica. Visando contribuir para esclarecer a ocorrência de valores elevados de Hg em peixes consumidos pela população de Rio Branco - AC, o Instituto Evandro Chagas - IEC, realizou um estudo para quantificar os teores de Hg em sedimentos de fundo e material particulado no rio Acre e alguns afluentes, além da caracterização físico-química das águas entre as cidades de Brasiléia e Assis Brasil. As amostras de sedimentos foram peneiradas na fração Mercury levels assessment in aquatic systems areas without influences of antropogenic sources have not been well studied in the Amazon region. For the identification of the origin of high values of Hg in fish consumed by population of Rio Branco City - AC, the Evandro Chagas Institute - IEC, studied the mercury levels in sediments, suspended solids and studied also the physical-chemical characterization of waters, in the Acre river and also some in afluents, between Brasiléia and Assis Brasil cities. Bottom sediments samples were sieved to <250 mesh fraction after drying. The suspended solid was obtained by precipitation with Al2SO4. About 250 mg of the material was submitted the acid digestion and the determinations of Hg were made by Could Vapor Atomic Absorption Spectrometry. The physical-chemical parameters pH, electric conductivity, temperature and dissolved total solids, were studied in the field, by potenciometric methods. The Hg levels in bottom sediments range 0,018 and 0,184 mug g-1, mean of 0,054 ± 0,034 mug g-1, while the suspended solids varied between 0,067 and 0,220 mug g-1, average of 0,098 ± 0,037 mug g-1. The waters were slightly acid with pH varying among 5,80 - 6,95 and conductivity electric 151,60 - 1.151,00 muS cm-1. The mercury levels in the analyzed materials was below of standard levels for

Fostering resilience in National Guard and Reserve families: A contextual adaptation of an evidence-based parenting program.

Science.gov (United States)

Pinna, Keri L M; Hanson, Sheila; Zhang, Na; Gewirtz, Abigail H

2017-01-01

Military deployment of a parent is a risk factor for children's internalizing and externalizing problems. This risk may be heightened in National Guard and Reserve (NG/R) families who tend to be isolated from other NG/R families and do not benefit from the centralized support system available to active duty families living on military bases. Isolation and trauma-related disorders may complicate the adjustment of military families during reintegration. An evidence-based parent training intervention was modified to meet the unique needs of recently deployed NG/R parents and their spouses, and the modified program was evaluated in a randomized controlled trial. The current study examines engagement and satisfaction with the program. Modifications such as employment of military-connected facilitators sought to maximize engagement in and satisfaction with the program. Engagement and satisfaction were examined between mothers and fathers, as well as between groups led by a military-connected facilitator and those led by civilian facilitators. Significantly greater engagement was noted for groups that were led by a military-connected facilitator (p = .01). There were no differences between genders in attendance rates, though greater positive group experiences were reported by mothers versus fathers (p = .01). Results are discussed in the context of engagement and satisfaction reported for similar programs. Implications for working with military families are also considered. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

49 CFR 17.4 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 17.4 Section 17.4 Transportation Office of the Secretary of Transportation INTERGOVERNMENTAL REVIEW OF DEPARTMENT OF TRANSPORTATION PROGRAMS AND ACTIVITIES § 17.4 [Reserved] ...

The situation of radiation oncology training programs and their graduates in 1997

International Nuclear Information System (INIS)

Crewson, Philip E.; Sunshine, Jonathan H.; Schepps, Barbara

1999-01-01

Purpose: In light of concerns about the job market, the American College of Radiology (ACR) studied the employment situation of 1997 radiation oncology graduates, and the status and plans of radiation oncology training programs. Methods and Materials: In April-May 1997, and in a December follow-up, the ACR surveyed all radiation oncology residency directors about the employment situation of their 1997 residency and fellowship graduates and about their programs. Ninety-four percent of those surveyed responded. We compared findings with surveys from 1995 and 1996. Differences were assessed with p ≤ 0.05 as the test of statistical significance. Results: By six months after graduation, 98% of residency graduates and all fellowship graduates were employed. Program directors reported approximately 95% of graduates had positions that reasonably matched their training and personal employment goals. Programs have reduced beginning residency slots by 22% over the past three years, and further reductions are planned. Many observers were disappointed with fill rates in the 1997 National Match, but by the December follow-up, 96% of beginning-year residency slots were filled. Conclusion: Unemployment continues to be low, and one 'softer' indicator, the job market perceptions of residency program directors, showed improvement

Modelling of liquid injection shutdown system (LISS) in ACR-1000

International Nuclear Information System (INIS)

Boubcher, M.; Colton, A.; Donnelly, J.V.

2008-01-01

Modelling of the Liquid Injection Shutdown System (LISS) in the ACR-1000 reactor core must account for the major phenomena that occur following its activation, namely the moderator hydraulics and core neutronics. The former requires modelling of the poison volumes, their time of entry into the reactor, and their propagation into the moderator after emission from the nozzle. The latter requires the reactivity worth of varying volumes and geometries of poisoned moderator fluid in order to simulate the reactivity effect of the injected poison. The time-dependent poison map is generated from hydraulic calculations, and then the neutronics data for standard geometries and concentrations is constructed using DRAGON. (author)

Antibacterial Efficacy of Polysaccharide Capped Silver Nanoparticles Is Not Compromised by AcrAB-TolC Efflux Pump

Directory of Open Access Journals (Sweden)

Mitali Mishra

2018-05-01

Full Text Available Antibacterial therapy is of paramount importance in treatment of several acute and chronic infectious diseases caused by pathogens. Over the years extensive use and misuse of antimicrobial agents has led to emergence of multidrug resistant (MDR and extensive drug resistant (XDR pathogens. This drastic escalation in resistant phenotype has limited the efficacy of available therapeutic options. Thus, the need of the hour is to look for alternative therapeutic approaches to mitigate healthcare concerns caused due to MDR bacterial infections. Nanoparticles have gathered much attention as potential candidates for antibacterial therapy. Equipped with advantages of, wide spectrum bactericidal activity at very low dosage, inhibitor of biofilm formation and ease of permeability, nanoparticles have been considered as leading therapeutic candidates to curtail infections resulting from MDR bacteria. However, substrate non-specificity of efflux pumps, particularly those belonging to resistance nodulation division super family, have been reported to reduce efficacy of many potent antibacterial therapeutic drugs. Previously, we had reported antibacterial activity of polysaccharide-capped silver nanoparticles (AgNPs toward MDR bacteria. We showed that AgNPs inhibits biofilm formation and alters expression of cytoskeletal proteins FtsZ and FtsA, with minimal cytotoxicity toward mammalian cells. In the present study, we report no reduction in antibacterial efficacy of silver nanoparticles in presence of AcrAB-TolC efflux pump proteins. Antibacterial tests were performed according to CLSI macrobroth dilution method, which revealed that both silver nanoparticles exhibited bactericidal activity at very low concentrations. Further, immunoblotting results indicated that both the nanoparticles modulate the transporter AcrB protein expression. However, expression of the membrane fusion protein AcrA did show a significant increase after exposure to AgNPs. Our results

40 CFR 73.51 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 73.51 Section 73.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Transfers § 73.51 [Reserved] ...

40 CFR 73.11 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 73.11 Section 73.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations § 73.11 [Reserved] ...

Effect of multicell DRAGON calculations depends on the environment on the DONJON predictions for the ACR-1000

International Nuclear Information System (INIS)

Duquette, J.-S.

2009-01-01

For understanding the behavior of a nuclear reactor core, it is necessary to make a full core calculation in order to compute the neutrons flux. To obtain the neutrons flux, solving the Boltzmann transport equation is required. That is not a simple task and it is impossible to analytically fend the solution of the neutrons transport equation on a complex core. Following a series of approximations, it is possible to numerically solve the neutrons transport equation. The solution of this equation is done step by step. Calculations will be performed over the ACR-1000 core. The Advanced CANDU Reactor (ACR-1000) is a generation III+ heavy water moderated and light water cooled reactor. It is a 1200 MW(e) power reactor. Amongst the ACR-1000 design parameters that differ from the CANDU 6, the reduced lattice pitch and the use of light water coolant and enriched fuel are the three most important. Those features modify the behavior of the neutrons in the ACR compared to the CANDU 6. The impact of the tight lattice is that a cell is more strongly coupled to its neighbor. The objective of this work is to determine the impact of the environment on the cell properties of the ACR-1000. Those properties will be used to perform full core calculations. The neutron transport calculations are performed with DRAGON whereas for the diffusion calculation on a full core. The code DONJON will be used. The DRAGON reference transport calculation will be made on a single cell. Then, a series of calculations will be performed using DRAGON over two types of assemblies, the first modelling the core interior and the second, modelling the core periphery. Moreover, the fuel age will sometimes be homogeneous, sometimes heterogeneous. The fuel will be burned during six hundred days. One thus obtains libraries of macroscopic cross sections over a six hundred days interval for various simulations. Thereafter, we will determine the effect of a neutrons transport multicell calculation on various DONJON

MCNP Simulations of End Flux Peaking in ACR-1000, 2.4 wt % {sup 235}U Fuel Bundles

Energy Technology Data Exchange (ETDEWEB)

Hill, Ian; Donnelly, Jim [Atomic Energy of Canada Limited (AECL), 2251 Speakman Drive, Mississauga, ON, L5K 1B2 (Canada)

2008-07-01

This paper examines the end flux peaking in ACR-1000 fuel bundles. Reactor physics simulations are performed with MCNP to assess the steady state end-flux peaking in an infinite lattice of ACR fuel, as well as to quantify the peaking that occurs during refuelling. 3-dimensional MCNP models are created based on the detailed geometry of the fuel bundle. Detailed position-dependent fuel compositions are obtained from MONTEBURNS which couples MCNP and ORIGIN2.2. Axial and radial power profiles are obtained for both fresh and mid-burnup fuel bundles in an infinite lattice. Subsequently an assessment of the impact of a refuelling transient on the power profiles is performed. The refuelling transient is found to increase the end flux peaking in the region adjacent to light water. (authors)

40 CFR 73.32 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 73.32 Section 73.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Tracking System § 73.32 [Reserved] ...

Revelation and cloning of valinomycin synthetase genes in Streptomyces lavendulae ACR-DA1 and their expression analysis under different fermentation and elicitation conditions.

Science.gov (United States)

Sharma, Richa; Jamwal, Vijaylakshmi; Singh, Varun P; Wazir, Priya; Awasthi, Praveen; Singh, Deepika; Vishwakarma, Ram A; Gandhi, Sumit G; Chaubey, Asha

2017-07-10

Streptomyces species are amongst the most exploited microorganisms due to their ability to produce a plethora of secondary metabolites with bioactive potential, including several well known drugs. They are endowed with immense unexplored potential and substantial efforts are required for their isolation as well as characterization for their bioactive potential. Unexplored niches and extreme environments are host to diverse microbial species. In this study, we report Streptomyces lavendulae ACR-DA1, isolated from extreme cold deserts of the North Western Himalayas, which produces a macrolactone antibiotic, valinomycin. Valinomycin is a K + ionophoric non-ribosomal cyclodepsipeptide with a broad range of bioactivities including antibacterial, antifungal, antiviral and cytotoxic/anticancer activities. Production of valinomycin by the strain S. lavendulae ACR-DA1 was studied under different fermentation conditions like fermentation medium, temperature and addition of biosynthetic precursors. Synthetic medium at 10°C in the presence of precursors i.e. valine and pyruvate showed enhanced valinomycin production. In order to assess the impact of various elicitors, expression of the two genes viz. vlm1 and vlm2 that encode components of heterodimeric valinomycin synthetase, was analyzed using RT-PCR and correlated with quantity of valinomycin using LC-MS/MS. Annelid, bacterial and yeast elicitors increased valinomycin production whereas addition of fungal and plant elicitors down regulated the biosynthetic genes and reduced valinomycin production. This study is also the first report of valinomycin biosynthesis by Streptomyces lavendulae. Copyright © 2017 Elsevier B.V. All rights reserved.

Biosphere reserves: Attributes for success.

Science.gov (United States)

Van Cuong, Chu; Dart, Peter; Hockings, Marc

2017-03-01

Biosphere reserves established under the UNESCO Man and the Biosphere Program aim to harmonise biodiversity conservation and sustainable development. Concerns over the extent to which the reserve network was living up to this ideal led to the development of a new strategy in 1995 (the Seville Strategy) to enhance the operation of the network of reserves. An evaluation of effectiveness of management of the biosphere reserve network was called for as part of this strategy. Expert opinion was assembled through a Delphi Process to identify successful and less successful reserves and investigate common factors influencing success or failure. Ninety biosphere reserves including sixty successful and thirty less successful reserves in 42 countries across all five Man and the Biosphere Program regions were identified. Most successful sites are the post-Seville generation while the majority of unsuccessful sites are pre-Seville that are managed as national parks and have not been amended to conform to the characteristics that are meant to define a biosphere reserve. Stakeholder participation and collaboration, governance, finance and resources, management, and awareness and communication are the most influential factors in the success or failure of the biosphere reserves. For success, the biosphere reserve concept needs to be clearly understood and applied through landscape zoning. Designated reserves then need a management system with inclusive good governance, strong participation and collaboration, adequate finance and human resource allocation and stable and responsible management and implementation. All rather obvious but it is difficult to achieve without commitment to the biosphere reserve concept by the governance authorities. Copyright © 2016 Elsevier Ltd. All rights reserved.

7 CFR 2201.2-2201.8 - [Reserved

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false [Reserved] 2201.2-2201.8 Section 2201.2-2201.8 Agriculture Regulations of the Department of Agriculture (Continued) LOCAL TELEVISION LOAN GUARANTEE BOARD LOCAL TELEVISION LOAN GUARANTEE PROGRAM-PROGRAM REGULATIONS General §§ 2201.2-2201.8 [Reserved] ...

Pinellas County, Florida Site Environmental Restoration Project Semiannual Progress Report for the 4.5 Acre Site June through November 2016 January 2017

International Nuclear Information System (INIS)

Survochak, Scott; Daniel, Joe

2017-01-01

This Pinellas County, Florida, Site Environmental Restoration Project Semiannual Progress Report for the 4.5 Acre Site describes environmental restoration activities for the 4.5 Acre Site located in Pinellas County, Largo, Florida (Figure 1). The former U.S. Department of Energy (DOE) Pinellas Plant facility consisted of the 4.5 Acre Site and what is now the STAR Center (Young - Rainey Science, Technology, and Research Center). Both the 4.5 Acre Site and the STAR Center are part of the overall Pinellas County, Florida, Site (Figure 2). The 4.5 Acre Site is located immediately northwest of the STAR Center, in the northeast quarter of Section 13, Township 30 South, Range 15 East. DOE owned this parcel from 1957 to 1972, at which time it was sold to a private landowner. During the period of DOE ownership, the property was used for the disposal of drums of waste resins and solvents. As a result of this practice, the surficial aquifer was impacted by volatile organic compounds (VOCs)-trichloroethene (TCE), cis-1,2-dichloroethene (cDCE), trans-1,2-dichloroethene (tDCE), vinyl chloride (VC), and benzene. Detailed background information for the site is contained in the Long-Term Surveillance and Maintenance Plan for the Pinellas Site (DOE 2016). That document and other site-related documents can be accessed at this website: http://www.lm.doe.gov/Pinellas/Sites.aspx. Recent remediation activities consist of the injection of emulsified soybean oil and the microorganism Dehalococcoides mccartyi (formerly known as Dehalococcoides ethenogenes) into the subsurface in February 2010 and again in July 2013 to enhance contaminant biodegradation (hereafter described as bioinjection). Monitoring the performance of these actions, in the form of monitoring well sampling, is ongoing.

Pinellas County, Florida Site Environmental Restoration Project Semiannual Progress Report for the 4.5 Acre Site June through November 2016 January 2017

Energy Technology Data Exchange (ETDEWEB)

Survochak, Scott [USDOE Office of Legacy Management, Washington, DC (United States); Daniel, Joe [Navarrao Research and Engineering, Inc., Oak Ridge, TN (United States)

2017-01-01

This Pinellas County, Florida, Site Environmental Restoration Project Semiannual Progress Report for the 4.5 Acre Site describes environmental restoration activities for the 4.5 Acre Site located in Pinellas County, Largo, Florida (Figure 1). The former U.S. Department of Energy (DOE) Pinellas Plant facility consisted of the 4.5 Acre Site and what is now the STAR Center (Young - Rainey Science, Technology, and Research Center). Both the 4.5 Acre Site and the STAR Center are part of the overall Pinellas County, Florida, Site (Figure 2). The 4.5 Acre Site is located immediately northwest of the STAR Center, in the northeast quarter of Section 13, Township 30 South, Range 15 East. DOE owned this parcel from 1957 to 1972, at which time it was sold to a private landowner. During the period of DOE ownership, the property was used for the disposal of drums of waste resins and solvents. As a result of this practice, the surficial aquifer was impacted by volatile organic compounds (VOCs)—trichloroethene (TCE), cis-1,2-dichloroethene (cDCE), trans-1,2-dichloroethene (tDCE), vinyl chloride (VC), and benzene. Detailed background information for the site is contained in the Long-Term Surveillance and Maintenance Plan for the Pinellas Site (DOE 2016). That document and other site-related documents can be accessed at this website: http://www.lm.doe.gov/Pinellas/Sites.aspx. Recent remediation activities consist of the injection of emulsified soybean oil and the microorganism Dehalococcoides mccartyi (formerly known as Dehalococcoides ethenogenes) into the subsurface in February 2010 and again in July 2013 to enhance contaminant biodegradation (hereafter described as bioinjection). Monitoring the performance of these actions, in the form of monitoring well sampling, is ongoing.

EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria.

Science.gov (United States)

van der Heijde, Désirée; van der Helm-van Mil, Annette H M; Aletaha, Daniel; Bingham, Clifton O; Burmester, Gerd R; Dougados, Maxime; Emery, Paul; Felson, David; Knevel, Rachel; Kvien, Tore K; Landewé, Robert B M; Lukas, Cédric; McInnes, Iain; Silman, Alan J; Smolen, Josef S; Stanislawska-Biernat, Ewa; Zink, Angela; Combe, Bernard

2013-04-01

The aim of this report was to propose a definition for erosive disease in the context of inflammatory arthritis in light of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria for use in clinical practice and studies. A EULAR task force was formed including 16 rheumatologists and one rheumatology fellow. The process was both evidence based and consensus based, and included, between March 2010 and April 2012, analyses of data from two cohorts, two face-to-face meetings, one online voting and one teleconference. The Leiden Early Arthritis Cohort and the French ESPOIR cohort were used for the evidence-based part. The outcome measures, which were initiation of methotrexate therapy, or any disease-modifying antirheumatic drug therapy within the first year of disease and arthritis persistency over 5 years, were studied with the aim to give the best definition of erosive disease. A decision was made to select a definition with a high specificity and focus on patients who did not otherwise fulfil the 2010 ACR/EULAR RA criteria (definition was selected: erosive disease for use in the 2010 ACR/EULAR RA classification criteria is defined when an erosion (defined as a cortical break) is seen in at least three separate joints at any of the following sites: the proximal interphalangeal, the metacarpophalangeal, the wrist (counted as one joint) and the metatarsophalangeal joints on radiographs of both hands and feet. A highly specific definition for erosive disease has thus been formulated.

The correlates of urinary albumin to creatinine ratio (ACR) in a high risk Australian aboriginal community.

Science.gov (United States)

Wang, Zaimin; Hoy, Wendy E; Wang, Zhiqiang

2013-08-16

Albuminuria marks renal disease and cardiovascular risk. It was estimated to contribute 75% of the risk of all-cause natural death in one Aboriginal group. The urine albumin/creatinine ratio (ACR) is commonly used as an index of albuminuria. This study aims to examine the associations between demographic factors, anthropometric index, blood pressure, lipid-protein measurements and other biomarkers and albuminuria in a cross-sectional study in a high-risk Australian Aboriginal population. The models will be evaluated for albuminuria at or above the microalbuminuria threshold, and at or above the "overt albuminuria" threshold with the potential to distinguish associations they have in common and those that differ. This was a cross-sectional study of 598 adults aged 18-76 years. All participants were grouped into quartiles by age. Logistic regression models were used to explore the correlates of ACR categories. The significant correlates were systolic blood pressure (SBP), C-reactive protein (CRP), uric acid, diabetes, gamma-glutamyl transferase (GGT) (marginally significant, p=0.054) and serum albumin (negative association) for ACR 17+ (mg/g) for men and 25+ for women. Independent correlates were SBP, uric acid, diabetes, total cholesterol, alanine amino transferase (ALT), Cystatin C and serum albumin (negative association) for overt albuminuria; and SBP, CRP and serum albumin only for microalbuminuria. This is the most detailed modelling of pathologic albuminuria in this setting to date. The somewhat variable association with risk factors suggests that microalbuminuria and overt albuminuria might reflect different as well as shared phenomena.

Conservation Reserve Program (CRP) contributions to wildlife habitat, management issues, challenges and policy choices--an annotated bibliography

Science.gov (United States)

Allen, Arthur W.; Vandever, Mark W.

2012-01-01

The following bibliography presents brief summaries of documents relevant to Conservation Reserve Program relations to wildlife habitat, habitat management in agriculturally dominated landscapes, and conservation policies potentially affecting wildlife habitats in agricultural ecosystems. Because the literature summaries furnished provide only sweeping overviews, users are urged to obtain and evaluate those papers appearing useful to obtain a more complete understanding of study findings and their implications to conservation in agricultural ecosystems. The bibliography contains references to reports that reach beyond topics that directly relate to the Conservation Reserve Program. Sections addressing grassland management and landowner surveys/opinions, for example, furnish information useful for enhancing development and administration of conservation policies affecting lands beyond those enrolled in conservation programs. Some sections of the bibliography (for example, agricultural conservation policy, economics, soils) are far from inclusive of all relevant material written on the subject. Hopefully, these sections will serve as fundamental introductions to related issues. In a few instances, references may be presented in more than one section of the bibliography. For example, individual papers specifically addressing both non-game and game birds are included in respective sections of the bibliography. Duplication of citations and associated notes has, however, been kept to a minimum.

Toxoplasma gondii antibodies in domiciled cats from rio branco Municipality, Acre State, Brazil

Directory of Open Access Journals (Sweden)

Soraia Figueiredo de Souza

2015-12-01

Full Text Available Blood samples were collected from 89 cats to assess the prevalence of IgG antibodies against Toxoplasma gondii by indirect immunofluorescence (IIF and the possible risk factors associated with feline Toxoplasma gondii infection. An epidemiological questionnaire was developed and implemented for owners of domestic cats domiciled in Rio Branco, Acre. The results were statistically evaluated with the odds ratio and chi-square tests, considering the significance level of 5%. Of 89 animals’ samples, 22 had antibodies against Toxoplasma gondii. Among the 22 reactive animals, 15 (68.19% were female, 15 (68.19% were less than one year old and 20 (90% were cross breed. Concerning risk factors, there was no difference (p > 0.05 between the variables evaluated by the chi-square test. Moreover, 16 (72% cats were fed a mixed diet, 20 (90% of the cats had hunting habits, 18 (81% had contact with animals of another species, 11 (50% had access to the street, and 22 (95% lived in homes that had areas of grass or dirt. In conclusion, the prevalence of anti-Toxoplasma gondii in domestic cats was 22.7%, and there were no significant risk factors for feline toxoplasmosis in the municipality of Rio Branco, Acre.

7 CFR 1776.4 - [Reserved

Science.gov (United States)

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1776.4 Section 1776.4 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) HOUSEHOLD WATER WELL SYSTEM GRANT PROGRAM General § 1776.4 [Reserved] ...

Por que um Estado com vocação florestal como o Acre não produz palmito?

Directory of Open Access Journals (Sweden)

Markus Erwin Brose

2016-04-01

Full Text Available Palm heart constitutes a major non-timber forest product within the pro poor development strategy in Acre State. The 1990s it witnessed a boom of native palm processing, that proved to be unsustainable and processing units migrated to northern Bolivia. This article aims to rescue the impacts of this process, and subsequent initiatives of peach palm cultivation, originated by public and private, which, however, experienced difficulties to access the market. Given the scarce bibliography on the topic, we seek to contribute to the debate of this productive chain in Acre as an input to the debate on strategies to support the marketing of non-wood forest products, essential to the state’s policy of providing value to the standing forest.

Efficacy of an Interinstitutional Mentoring Program Within Pediatric Rheumatology.

Science.gov (United States)

Moorthy, Lakshmi Nandini; Muscal, Eyal; Riebschleger, Meredith; Klein-Gitelman, Marisa; Nigrovic, Lise E; Horon, Jeffrey R; Rouster-Stevens, Kelly; Ferguson, Polly J; Eberhard, B Anne; Brunner, Hermine I; Prahalad, Sampath; Schneider, Rayfel; Nigrovic, Peter A

2016-05-01

The small size of many pediatric rheumatology programs translates into limited mentoring options for early career physicians. To address this problem, the American College of Rheumatology (ACR) and the Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed a subspecialty-wide interinstitutional mentoring program, the ACR/CARRA Mentoring Interest Group (AMIGO). We sought to assess the impact of this program on mentoring within pediatric rheumatology. In a longitudinal 3-year study, participant ratings from the AMIGO pilot program were compared with those after the program was opened to general enrollment. Access to mentoring as a function of career stage was assessed by surveys of the US and Canadian pediatric rheumatologists in 2011 and 2014, before and after implementation of AMIGO. Participants in the pilot phase (19 dyads) and the general implementation phase (112 dyads) reported comparable success in establishing mentor contact, suitability of mentor-mentee pairing, and benefit with respect to career development, scholarship, and work-life balance. Community surveys showed that AMIGO participation as mentee was high among fellows (86%) and modest among junior faculty (31%). Implementation correlated with significant gains in breadth of mentorship and in overall satisfaction with mentoring for fellows but not junior faculty. AMIGO is a career mentoring program that serves most fellows and many junior faculty in pediatric rheumatology across the US and Canada. Program evaluation data confirm that a subspecialty-wide interinstitutional mentoring program is feasible and can translate into concrete improvement in mentoring, measurable at the level of the whole professional community. © 2016, American College of Rheumatology.

Caracterização físico-quimica de farinhas oriundas de variedades de mandioca utilizadas no vale do Juruá, Acre Physicochemical characteristics of flours deriving of cassava varieties used in the Vale do Juruá, Acre

Directory of Open Access Journals (Sweden)

Joana Maria Leite de Souza

2008-12-01

Full Text Available Algumas características de farinha de mandioca dependem da variedade da raiz utilizada para o processamento. Objetivou-se avaliar as características físico-químicas da farinha de mandioca oriundas de variedades utilizadas no estado do Acre. Os tratamentos foram compostos pelas variedades: T1= Paxiubão, T2= Im221, T3 = Caboquinha, T4 = Araçá, T5 = Colonial, T6 = Branquinha, T7 = Panati e T8 = Mansa e Brava. Foram coletadas amostras das oito variedades de mandioca em casas-de-farinha no município de Cruzeiro do Sul, Acre. As raízes foram transportadas via aérea para o Laboratório de Tecnologia de Alimentos da Embrapa-AC, na cidade de Rio Branco, Acre. Foram avaliados: teor de umidade, cinzas, lipídios, proteína, fibra bruta, carboidratos, acidez, pH e atividade de água. Todas as amostras se apresentaram de acordo com os padrões estabelecidos pela Legislação Brasileira para farinha de mandioca quanto ao teor de umidade, cinzas e carboidratos. As farinhas analisadas apresentam teores baixos de fibras e baixa acidez. A atividade de água das farinhas analisadas esteve abaixo do limite mínimo capaz de permitir o desenvolvimento de microrganismos. As variedades Araçá, Colonial e Branquinha se mostraram adequadas para a fabricação de farinha de mandioca devido, principalmente, ao elevado teor de proteína e carboidratos presente nas farinhas produzidas.Some characteristics of the cassava depend on the variety used for the processing. The objectified of this study was to evaluate physicochemical characteristics of the cassava flour from varieties used in Acre. The treatments were composed by the varieties: T1 = Paxiubão, T2 = Im221, T3 = Caboquinha, T4 = Araçá, T5 = Colonial, T6 = Branquinha, T7 = Panati and T8 = Mansa e Brava. Samples of flour of eight cassava varieties were collect in cassava mils in Cruzeiro do Sul. The samples were sent by airmail to Rio Branco, Acre, to be analyzed in the Food and Technology Laboratory at

Oak Ridge Reservation Federal Facility Agreement for the Environmental Restoration Program. Volume 4

International Nuclear Information System (INIS)

1993-10-01

This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program that are specified in the Oak Ridge Reservation (ORR) Federal Facility Agreement (FFA) established between the U.S. Department of Energy (DOE), the U.S. Environmental protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered is July through September 1993 (fourth quarter of FY 1993). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been approved as FY 1994 commitments

EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria

NARCIS (Netherlands)

van der Heijde, Désirée; van der Helm-van Mil, Annette H. M.; Aletaha, Daniel; Bingham, Clifton O.; Burmester, Gerd R.; Dougados, Maxime; Emery, Paul; Felson, David; Knevel, Rachel; Kvien, Tore K.; Landewé, Robert B. M.; Lukas, Cédric; McInnes, Iain; Silman, Alan J.; Smolen, Josef S.; Stanislawska-Biernat, Ewa; Zink, Angela; Combe, Bernard

2013-01-01

The aim of this report was to propose a definition for erosive disease in the context of inflammatory arthritis in light of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria for use in clinical practice and studies. A EULAR

Freqüência de anemia infecciosa em eqüinos no Acre, 1986 a 1996

Directory of Open Access Journals (Sweden)

Santos R.M.L.

2001-01-01

Full Text Available Foram analisadas as fichas de 9.963 eqüídeos do Acre, submetidos ao teste de imunodifusão em gel de ágar (IDGA para anemia infecciosa eqüina (AIE, no período de 1986 a 1996. As regiões sócio-ecológicas da Bacia do Alto Juruá, Alto Acre e Alta Bacia do Purus apresentaram os maiores índices da doença, o que caracteriza a associação entre região e positividade. Essas áreas são fronteiriças com o Peru, Bolívia e o Estado do Amazonas, são distantes de Rio Branco, capital do Estado, onde muitas vezes é difícil o acesso pelas estradas, revelando serem áreas de risco. As regiões Oriental e Rio Branco apresentaram baixos índices de positividade. Não se observou diferença estatística entre animais positivos e negativos quanto à espécie, sexo, raça e idade.

Water quality data collected by the the National Estuarine Research Reserve System's System-wide Monitoring Program (NERRS SWMP), 1996 - 1998 (NODC Accession 0000789)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The National Estuarine Research Reserve System's System-wide Monitoring Program (NERRS SWMP) collected water quality data in 22 reserves in the United States and...

A report from the American college of rheumatology/association of rheumatology health professionals (ACR/ARHP) - 2012 annual meeting (November 9-14, 2012 - Washington, D.C., USA).

Science.gov (United States)

Croasdell, G

2013-02-01

The annual meeting of the American College of Rheumatology (ACR), jointly held with the Association of Rheumatology Health Professionals (ARHP), brought together attendees focused on all aspects of rheumatology, including researchers looking into treatment options and various services around the care of rheumatologic conditions. As well as networking opportunities at the meeting, there were a wide range of symposia and posters available covering various conditions and levels of research. There were also educational and meet-the-professor sessions. This report will cover a selection of interesting talks from poster and oral sessions on the latest preclinical and clinical research. Copyright 2013 Prous Science, S.A.U. or its licensors. All rights reserved.

Implementing a reward and reminder underage drinking prevention program in convenience stores near Southern California American Indian reservations.

Science.gov (United States)

Moore, Roland S; Roberts, Jennifer; McGaffigan, Richard; Calac, Daniel; Grube, Joel W; Gilder, David A; Ehlers, Cindy L

2012-09-01

Underage drinking is associated with a number of social and public health consequences. Preventing access to alcohol is one approach to reducing underage drinking. This study assesses the efficacy of a culturally tailored "reward and reminder" program aimed at reducing convenience store alcohol sales to youth living on or near nine American Indian reservations. First, tribal council proclamations were sought to support underage drinking prevention, including reward and reminder efforts. Then, decoys (volunteers over 21 years of age but judged to look younger) attempted to purchase alcohol without identification. Clerks who asked for identification were given "rewards" (gift cards and congratulatory letters), whereas clerks who did not were given "reminders" of the law regarding sales to minors. Following an initial baseline of 12 purchase attempts, three repeated reward and reminder visits were made to 13 convenience stores selling alcohol within 10 miles of the reservations (n = 51 total attempts). Five of nine tribal councils passed resolutions in support of the program. The baseline sales rate without requesting ID was 33%. Similarly, 38% of stores in the first reward and reminder visit round failed to request identification. However, in the following two reward and reminder rounds, 0% of the stores failed to request identification. These results indicate that environmental community-level underage drinking prevention strategies to reduce alcohol sales near rural reservations are feasible and can be effective. Environmental prevention strategies within reservation communities support integrated supply and demand reduction models for reducing underage drinking.

Landowner and practitioner perspectives on private land conservation programs

Science.gov (United States)

Lute, Michelle L.; Gillespie, Caitlyn R.; Fontaine, Joseph J.; Martin, Dustin R.

2018-01-01

Efforts to reverse declines in native grasslands benefit from agricultural policies that encourage private land conservation. The U.S. Department of Agriculture’s Conservation Reserve Program (CRP) improved conservation across landscapes but enrollment has declined. We used sequential exploratory mixed methods to compare landowner and conservation practitioners’ perceptions, evaluate perceived benefits, and identify potential improvements to CRP. Focus groups of practitioners informed a quantitative survey of landowners who had properties >160 total acres in Nebraska. Results suggest potential misalignment in perceptions between practitioners and landowners. Practitioners were concerned that conservation, especially of wildlife, was secondary to profit. But the majority of landowners valued CRP-related ecosystem services, including native pollinators. Practitioners posited that younger landowners were primarily profit motivated, but CRP enrollment did not differ by demographics. Practitioners and landowners identified rule complexity as a major challenge and practitioner–landowner relationships as critical to success. Findings suggest that practitioners may underestimate non-economic motivations and illuminate opportunities to encourage private land conservation.

TU-F-CAMPUS-I-04: Head-Only Asymmetric Gradient System Evaluation: ACR Image Quality and Acoustic Noise

Energy Technology Data Exchange (ETDEWEB)

Weavers, P; Shu, Y; Tao, S; Bernstein, M [Mayo Clinic, Rochester, Minnesota (United States); Lee, S; Piel, J; Foo, T [GE Global Research, Niskayuna, NY (United States); Mathieu, J-B [GE Healthcare, Florence, SC (Italy)

2015-06-15

Purpose: A high-performance head-only magnetic resonance imaging gradient system with an acquisition volume of 26 cm employing an asymmetric design for the transverse coils has been developed. It is able to reach a magnitude of 85 mT/m at a slew rate of 700 T/m/s, but operated at 80 mT/m and 500 T/m/s for this test. A challenge resulting from this asymmetric design is that the gradient nonlinearly exhibits both odd- and even-ordered terms, and as the full imaging field of view is often used, the nonlinearity is pronounced. The purpose of this work is to show the system can produce clinically useful images after an on-site gradient nonlinearity calibration and correction, and show that acoustic noise levels fall within non-significant risk (NSR) limits for standard clinical pulse sequences. Methods: The head-only gradient system was inserted into a standard 3T wide-bore scanner without acoustic damping. The ACR phantom was scanned in an 8-channel receive-only head coil and the standard American College of Radiology (ACR) MRI quality control (QC) test was performed. Acoustic noise levels were measured for several standard pulse sequences. Results: Images acquired with the head-only gradient system passed all ACR MR image quality tests; Both even and odd-order gradient distortion correction terms were required for the asymmetric gradients to pass. Acoustic noise measurements were within FDA NSR guidelines of 99 dBA (with assumed 20 dBA hearing protection) A-weighted and 140 dB for peak for all but one sequence. Note the gradient system was installed without any shroud or acoustic batting. We expect final system integration to greatly reduce noise experienced by the patient. Conclusion: A high-performance head-only asymmetric gradient system operating at 80 mT/m and 500 T/m/s conforms to FDA acoustic noise limits in all but one case, and passes all the ACR MR image quality control tests. This work was supported in part by the NIH grant 5R01EB010065.

TU-F-CAMPUS-I-04: Head-Only Asymmetric Gradient System Evaluation: ACR Image Quality and Acoustic Noise

International Nuclear Information System (INIS)

Weavers, P; Shu, Y; Tao, S; Bernstein, M; Lee, S; Piel, J; Foo, T; Mathieu, J-B

2015-01-01

Purpose: A high-performance head-only magnetic resonance imaging gradient system with an acquisition volume of 26 cm employing an asymmetric design for the transverse coils has been developed. It is able to reach a magnitude of 85 mT/m at a slew rate of 700 T/m/s, but operated at 80 mT/m and 500 T/m/s for this test. A challenge resulting from this asymmetric design is that the gradient nonlinearly exhibits both odd- and even-ordered terms, and as the full imaging field of view is often used, the nonlinearity is pronounced. The purpose of this work is to show the system can produce clinically useful images after an on-site gradient nonlinearity calibration and correction, and show that acoustic noise levels fall within non-significant risk (NSR) limits for standard clinical pulse sequences. Methods: The head-only gradient system was inserted into a standard 3T wide-bore scanner without acoustic damping. The ACR phantom was scanned in an 8-channel receive-only head coil and the standard American College of Radiology (ACR) MRI quality control (QC) test was performed. Acoustic noise levels were measured for several standard pulse sequences. Results: Images acquired with the head-only gradient system passed all ACR MR image quality tests; Both even and odd-order gradient distortion correction terms were required for the asymmetric gradients to pass. Acoustic noise measurements were within FDA NSR guidelines of 99 dBA (with assumed 20 dBA hearing protection) A-weighted and 140 dB for peak for all but one sequence. Note the gradient system was installed without any shroud or acoustic batting. We expect final system integration to greatly reduce noise experienced by the patient. Conclusion: A high-performance head-only asymmetric gradient system operating at 80 mT/m and 500 T/m/s conforms to FDA acoustic noise limits in all but one case, and passes all the ACR MR image quality control tests. This work was supported in part by the NIH grant 5R01EB010065

Treatment-Induced Changes in Plasma Adiponectin Do Not Reduce Urinary Albumin Excretion in the Diabetes Prevention Program Cohort.

Directory of Open Access Journals (Sweden)

Kieren J Mather

Full Text Available Molecular data suggests that adiponectin may directly regulate urinary albumin excretion. In the Diabetes Prevention Program (DPP we measured adiponectin and albuminuria before and after intervention, and we previously reported increases in adiponectin with interventions. Here we have used the DPP dataset to test the hypothesis that treatment-related increases in adiponectin may reduce albuminuria in obesity.We evaluated cross-sectional correlations between plasma adiponectin and urinary albumin excretion at baseline, and the relationship of treatment-related changes in adiponectin and albuminuria. Baseline and follow-up urine albumin to creatinine ratios (ACR (albumin to creatinine ratio and plasma adiponectin concentration were available in 2553 subjects.Adjusting for age, sex and race/ethnicity, we observed a statistically significant but weak inverse relationship between adiponectin and ACR at baseline (conditional Spearman's rho = (- 0.04, p = 0.04. Although DPP treatments significantly increased plasma adiponectin, there were no treatment effects on ACR and no differences in ACR across treatment groups. There was a weak direct (not inverse association between change in adiponectin and change in albuminuria (adjusted Spearman's rho = (+ 0.04, p = 0.03.In a large, well-characterized cohort of obese dysglycemic subjects we observed a weak inverse association between circulating adiponectin concentrations and urinary albumin excretion at baseline. Contrary to the hypothesized effect, treatment-related increases in plasma adiponectin were not associated with a reduction in ACR. The association of change in adiponectin with change in ACR should be assessed in populations with overt albuminuria before excluding a beneficial effect of increasing adiponectin to reduce ACR in obesity.

7 CFR 1709.202 Policy. - [Reserved

Science.gov (United States)

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false [Reserved] 1709.202 Policy. Section 1709.202 Policy... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES Bulk Fuel Revolving Fund Grant Program § 1709.202 Policy. [Reserved] ...

Corrective Action Decision Document/Corrective Action Plan for the 92-Acre Area and Corrective Action Unit 111: Area 5 WMD Retired Mixed Waste Pits, Nevada Test Site, Nevada

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Restoration

2009-07-31

This Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) has been prepared for the 92-Acre Area, the southeast quadrant of the Radioactive Waste Management Site, located in Area 5 of the Nevada Test Site (NTS). The 92-Acre Area includes Corrective Action Unit (CAU) 111, 'Area 5 WMD Retired Mixed Waste Pits.' Data Quality Objectives (DQOs) were developed for the 92-Acre Area, which includes CAU 111. The result of the DQO process was that the 92-Acre Area is sufficiently characterized to provide the input data necessary to evaluate corrective action alternatives (CAAs) without the collection of additional data. The DQOs are included as Appendix A of this document. This CADD/CAP identifies and provides the rationale for the recommended CAA for the 92-Acre Area, provides the plan for implementing the CAA, and details the post-closure plan. When approved, this CADD/CAP will supersede the existing Pit 3 (P03) Closure Plan, which was developed in accordance with Title 40 Code of Federal Regulations (CFR) Part 265, 'Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities.' This document will also serve as the Closure Plan and the Post-Closure Plan, which are required by 40 CFR 265, for the 92-Acre Area. After closure activities are complete, a request for the modification of the Resource Conservation and Recovery Act Permit that governs waste management activities at the NTS will be submitted to the Nevada Division of Environmental Protection to incorporate the requirements for post-closure monitoring. Four CAAs, ranging from No Further Action to Clean Closure, were evaluated for the 92-Acre Area. The CAAs were evaluated on technical merit focusing on performance, reliability, feasibility, safety, and cost. Based on the evaluation of the data used to develop the conceptual site model; a review of past, current, and future operations at the site; and the detailed and comparative

Corrective Action Decision Document/Corrective Action Plan for the 92-Acre Area and Corrective Action Unit 111: Area 5 WMD Retired Mixed Waste Pits, Nevada Test Site, Nevada

International Nuclear Information System (INIS)

2009-01-01

This Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) has been prepared for the 92-Acre Area, the southeast quadrant of the Radioactive Waste Management Site, located in Area 5 of the Nevada Test Site (NTS). The 92-Acre Area includes Corrective Action Unit (CAU) 111, 'Area 5 WMD Retired Mixed Waste Pits.' Data Quality Objectives (DQOs) were developed for the 92-Acre Area, which includes CAU 111. The result of the DQO process was that the 92-Acre Area is sufficiently characterized to provide the input data necessary to evaluate corrective action alternatives (CAAs) without the collection of additional data. The DQOs are included as Appendix A of this document. This CADD/CAP identifies and provides the rationale for the recommended CAA for the 92-Acre Area, provides the plan for implementing the CAA, and details the post-closure plan. When approved, this CADD/CAP will supersede the existing Pit 3 (P03) Closure Plan, which was developed in accordance with Title 40 Code of Federal Regulations (CFR) Part 265, 'Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities.' This document will also serve as the Closure Plan and the Post-Closure Plan, which are required by 40 CFR 265, for the 92-Acre Area. After closure activities are complete, a request for the modification of the Resource Conservation and Recovery Act Permit that governs waste management activities at the NTS will be submitted to the Nevada Division of Environmental Protection to incorporate the requirements for post-closure monitoring. Four CAAs, ranging from No Further Action to Clean Closure, were evaluated for the 92-Acre Area. The CAAs were evaluated on technical merit focusing on performance, reliability, feasibility, safety, and cost. Based on the evaluation of the data used to develop the conceptual site model; a review of past, current, and future operations at the site; and the detailed and comparative analysis of the

Minimal requirements of ACR-NEMA digital imaging and communication standards

International Nuclear Information System (INIS)

Wang, Y.; Horrii, S.; Lehr, J.

1986-01-01

The American College of Radiology-National Electrical Manufacturers Association (ACR-NEMA) Digital Imaging and Communication Standards were formally adopted in December 1985. They are intended to facilitate management and communication of digital image information regardless of source, format, or device manufacturer; to promote the development and expansion of radiologic imaging and communication systems that can also interface with other systems of hospital information; and to allow the creation of diagnostic information databases that can be interrogated by a wide variety of devices distributed geographically. The Standards specify the hardware interface, a minimum set of software commands, and a consistent set of data formats for communication across the interface between an imaging device and a network interface unit or another imaging device

MANAGEMENT OF Amburana cearensis var. acreana IN ACRE STATE, BRAZIL

Directory of Open Access Journals (Sweden)

Evaldo Muñoz Braz

2014-06-01

Full Text Available http://dx.doi.org/10.5902/1980509814586This work has as its objectives: a to assess the geographical distribution and population structure of Amburana cearensis var. acreana; b to calculate sustainable cutting rates, according to stipulated cutting cycles, and c to simulate the projected recovery potential in volume based on the calculated cutting rate. It was used data from sustainable forest management plans, and the results will contribute for future decisions about its endangered condition. The results did not corroborate the information that Amburana cearensis var. acreana is endangered in Acre state. However the management sustainability will only be feasible if considered the ideal remaining population structure and the estimative of the optimal cutting rate according to the cutting cycle.

Office of Technology Development Program for Research, Development, Demonstration, Testing, and Evaluation. FY 1993 Program Summary

Energy Technology Data Exchange (ETDEWEB)

1993-10-01

DOE has set a goal to clean up its complex and to bring all sites into compliance with applicable environmental regulations. This initiative is slated for completion by the year 2019. Four years ago there was no coordinated plan for identifying or cleaning these contaminated sites. Since 1989, DOE`s Office of Environmental Restoration and Waste Management has invested time, money, and manpower to establish a wide range of programs to meet this immense challenge. DOE is responsible for waste management and clean up of more than 100 contaminated installations in 36 states and territories. This includes 3,700 sites: over 26,000 acres, with hazardous or radioactive contaminated surface or groundwater, soil, or structures; over 26,000 acres requiring remediation, with the number growing as new sites are defined; 500 surplus facilities awaiting decontamination and decommissioning and approximately 5,000 peripheral properties (residences, businesses) that have soil contaminated with uranium tailings.

Geriatric education across 94 million acres: adapting conference programming in a rural state.

Science.gov (United States)

Murphy-Southwick, Colleen; McBride, Melen

2006-01-01

Montana, a predominantly rural state, with a unique blend of geography and history, low population density, and cultural diversity represents the challenges for program development and implementation across remote areas. The paper discusses two statewide multidisciplinary geriatric education programs for health professionals offered by the recently established Montana Geriatric Education Center (MTGEC); use of telecommunications technology; collaborations with Geriatric Education Centers (GECs) and the Montana Healthcare Telemedicine Alliance (MHTA); and training outcomes, insights, and implications for continuing education of health professionals who practice in hard-to-reach regions. In addition, data from a statewide needs assessment are presented specific to preferred format. The MTGEC training model that combined traditional classroom and videoconference increased attendance by twofold and may be adapted in other regions to train providers in remote areas of the U.S.

Optimization of nonribosomal peptides production by a psychrotrophic fungus: Trichoderma velutinum ACR-P1.

Science.gov (United States)

Sharma, Richa; Singh, Varun P; Singh, Deepika; Yusuf, Farnaz; Kumar, Anil; Vishwakarma, Ram A; Chaubey, Asha

2016-11-01

Trichoderma is an anamorphic filamentous fungal genus with immense potential for production of small valuable secondary metabolites with indispensable biological activities. Microbial dynamics of a psychrotrophic strain Trichoderma velutinum ACR-P1, isolated from unexplored niches of the Shiwalik region, bestowed with rich biodiversity of microflora, was investigated for production of nonribosomal peptides (NRPs) by metabolite profiling by intact-cell mass spectrometry (ICMS) employing matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometer. Being the first report on NRPs production by T. velutinum, studies on optimization of growth conditions by Response Surface Methodology (RSM) for production of NRPs by ACR-P1 was carried out strategically. Multifold enhancement in the yield of NRPs belonging to subfamily SF4 with medium chain of amino acid residues having m/z 1437.9, 1453.9, and 1452.0 at pH 5.9 at 20 °C and of subfamily SF1 with long-chain amino acid residues having m/z 1770.2, 1784.2, 1800.1, 1802.1, and 1815.1 was achieved at pH 7.0 at 25 °C. Complexities of natural mixtures were thus considerably reduced under respective optimized culture conditions accelerating the production of novel microbial natural products by saving time and resources.

Multiple factors influence the vegetation composition of Southeast U.S. wetlands restored in the Wetlands Reserve Program

Science.gov (United States)

Diane De Steven; Joel M. Gramling

2013-01-01

Degradation of wetlands on agricultural lands contributes to the loss of local or regional vegetation diversity. The U.S. Department of Agriculture’s Wetlands Reserve Program (WRP) funds the restoration of degraded wetlands on private ‘working lands’, but these WRP projects have not been studied in the Southeast United States. Wetland hydrogeomorphic type influences...

The provisional ACR/EULAR definition of remission in RA : a comment on the patient global assessment criterion

NARCIS (Netherlands)

Vermeer, Marloes; Kuper, Hillechiena H.; van der Bijl, Arie E.; Baan, Henriette; Posthumus, Marcel D.; Brus, Herman L. M.; van Riel, Piet L. C. M.; van de Laar, Mart A. F. J.

Objectives. The provisional ACR/European League Against Rheumatism (EULAR) definition of remission in RA requires a score of 41 on the patient global assessment (PGA, 0-10 scale). We explored the relation between the PGA criterion and the patient's clinical disease state in an observational dataset.

Closure Report for the 92-Acre Area and Corrective Action Unit 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Restoration

2012-02-21

This Closure Report (CR) presents information supporting closure of the 92-Acre Area, which includes Corrective Action Unit (CAU) 111, 'Area 5 WMD Retired Mixed Waste Pits.' This CR provides documentation supporting the completed corrective actions and confirmation that the closure objectives were met. This CR complies with the requirements of the Federal Facility Agreement and Consent Order (FFACO) (FFACO, 1996 [as amended March 2010]). Closure activities began in January 2011 and were completed in January 2012. Closure activities were conducted according to Revision 1 of the Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) for the 92-Acre Area and CAU 111 (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office [NNSA/NSO], 2010). The following closure activities were performed: (1) Construct an engineered evapotranspiration cover over the boreholes, trenches, and pits in the 92-Acre Area; (2) Install use restriction (UR) warning signs, concrete monuments, and subsidence survey monuments; and (3) Establish vegetation on the covers. UR documentation is included as Appendix C of this report. The post-closure plan is presented in detail in Revision 1 of the CADD/CAP for the 92-Acre Area and CAU 111, and the requirements are summarized in Section 5.2 of this document. When the next request for modification of Resource Conservation and Recovery Act Permit NEV HW0101 is submitted to the Nevada Division of Environmental Protection (NDEP), the requirements for post-closure monitoring of the 92-Acre Area will be included. NNSA/NSO requests the following: (1) A Notice of Completion from NDEP to NNSA/NSO for closure of CAU 111; and (2) The transfer of CAU 111 from Appendix III to Appendix IV, Closed Corrective Action Units, of the FFACO.

Closure Report for the 92-Acre Area and Corrective Action Unit 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada

International Nuclear Information System (INIS)

2012-01-01

This Closure Report (CR) presents information supporting closure of the 92-Acre Area, which includes Corrective Action Unit (CAU) 111, 'Area 5 WMD Retired Mixed Waste Pits.' This CR provides documentation supporting the completed corrective actions and confirmation that the closure objectives were met. This CR complies with the requirements of the Federal Facility Agreement and Consent Order (FFACO) (FFACO, 1996 (as amended March 2010)). Closure activities began in January 2011 and were completed in January 2012. Closure activities were conducted according to Revision 1 of the Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) for the 92-Acre Area and CAU 111 (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO), 2010). The following closure activities were performed: (1) Construct an engineered evapotranspiration cover over the boreholes, trenches, and pits in the 92-Acre Area; (2) Install use restriction (UR) warning signs, concrete monuments, and subsidence survey monuments; and (3) Establish vegetation on the covers. UR documentation is included as Appendix C of this report. The post-closure plan is presented in detail in Revision 1 of the CADD/CAP for the 92-Acre Area and CAU 111, and the requirements are summarized in Section 5.2 of this document. When the next request for modification of Resource Conservation and Recovery Act Permit NEV HW0101 is submitted to the Nevada Division of Environmental Protection (NDEP), the requirements for post-closure monitoring of the 92-Acre Area will be included. NNSA/NSO requests the following: (1) A Notice of Completion from NDEP to NNSA/NSO for closure of CAU 111; and (2) The transfer of CAU 111 from Appendix III to Appendix IV, Closed Corrective Action Units, of the FFACO.

Registros de ocorrência e novos hospedeiros de Gargaphia lunulata (Mayr (Hemiptera: Tingidae nos estados do Acre e Paraná

Directory of Open Access Journals (Sweden)

Rodrigo Santos

2017-12-01

Abstract. The occurrence of Gargaphia lunulata (Mayr (Hemiptera: Tingidae was observed in leaves of four host plants: rue (Ruta graveolens L. and jack bean (Canavalia ensiformis (L. DC in an urban residential garden, in the municipality of Rio Branco, Acre State, Brazil and Crotalaria spectabilis (L., jack bean and okra (Abelmoschus esculentus L. Moench in a greenhouse, in the municipality of Londrina, Paraná State, Brazil. The colonies were found exclusively on the abaxial face of the leaves, causing chlorosis, wilting and early senescence of the same. Because G. lunulata is considered to be an important passion fruit pest in Brazil, the planting of the mentioned plant species, in intercropping or near to passion fruit crops, would not be recommended, since they could serve as plant species inoculum to passion fruit cultivation. Therefore, the occurrence of G. lunulata associated to R. graveolens and jack bean in Acre State; and C. spectabilis, jack bean, and okra, in Paraná State is record for the first time. In addition, the present work reports the first occurrence of this tingid to the States of Acre and Paraná and reports two new hosts for this insect, R. graveolens and C. spectabillis in Brazil.

Reserve Component Programs, Fiscal Year 1993. Report of the Reserve Forces Policy Board

Science.gov (United States)

1994-01-01

to induce or reinforce attitudes and behavior that Summary support the Theater CINC’s overall PSYOP campaign plan. Members of PSYOP units are Greater...Men.n AMRlt Wing. •Asfrlsk IMlctN Army Reserve spas puts doe for FY92 Is for on.hW yar due to k owmwilon of cosumer hin payment. Souros: Th Rmncao

Corrective Action Decision Document/Corrective Action Plan for the 92-Acre Area and Corrective Action Unit 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada

International Nuclear Information System (INIS)

2010-01-01

This Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) has been prepared for the 92-Acre Area, the southeast quadrant of the Radioactive Waste Management Site, located in Area 5 of the Nevada National Security Site (NNSS). The 92-Acre Area includes Corrective Action Unit (CAU) 111, 'Area 5 WMD Retired Mixed Waste Pits.' Data Quality Objectives (DQOs) were developed for the 92-Acre Area, which includes CAU 111. The result of the DQO process was that the 92-Acre Area is sufficiently characterized to provide the input data necessary to evaluate corrective action alternatives (CAAs) without the collection of additional data. The DQOs are included as Appendix A of this document. This CADD/CAP identifies and provides the rationale for the recommended CAA for the 92-Acre Area, provides the plan for implementing the CAA, and details the post-closure plan. When approved, this CADD/CAP will supersede the existing Pit 3 (P03) Closure Plan, which was developed in accordance with Title 40 Code of Federal Regulations (CFR) Part 265, 'Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities.' This document will also serve as the Closure Plan and the Post-Closure Plan, which are required by 40 CFR 265, for the 92-Acre Area. After closure activities are complete, a request for the modification of the Resource Conservation and Recovery Act Permit that governs waste management activities at the NNSS will be submitted to the Nevada Division of Environmental Protection to incorporate the requirements for post-closure monitoring. Four CAAs, ranging from No Further Action to Clean Closure, were evaluated for the 92-Acre Area. The CAAs were evaluated on technical merit focusing on performance, reliability, feasibility, safety, and cost. Based on the evaluation of the data used to develop the conceptual site model; a review of past, current, and future operations at the site; and the detailed and comparative

Corrective Action Decision Document/Corrective Action Plan for the 92-Acre Area and Corrective Action Unit 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Restoration

2010-11-22

This Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) has been prepared for the 92-Acre Area, the southeast quadrant of the Radioactive Waste Management Site, located in Area 5 of the Nevada National Security Site (NNSS). The 92-Acre Area includes Corrective Action Unit (CAU) 111, 'Area 5 WMD Retired Mixed Waste Pits.' Data Quality Objectives (DQOs) were developed for the 92-Acre Area, which includes CAU 111. The result of the DQO process was that the 92-Acre Area is sufficiently characterized to provide the input data necessary to evaluate corrective action alternatives (CAAs) without the collection of additional data. The DQOs are included as Appendix A of this document. This CADD/CAP identifies and provides the rationale for the recommended CAA for the 92-Acre Area, provides the plan for implementing the CAA, and details the post-closure plan. When approved, this CADD/CAP will supersede the existing Pit 3 (P03) Closure Plan, which was developed in accordance with Title 40 Code of Federal Regulations (CFR) Part 265, 'Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities.' This document will also serve as the Closure Plan and the Post-Closure Plan, which are required by 40 CFR 265, for the 92-Acre Area. After closure activities are complete, a request for the modification of the Resource Conservation and Recovery Act Permit that governs waste management activities at the NNSS will be submitted to the Nevada Division of Environmental Protection to incorporate the requirements for post-closure monitoring. Four CAAs, ranging from No Further Action to Clean Closure, were evaluated for the 92-Acre Area. The CAAs were evaluated on technical merit focusing on performance, reliability, feasibility, safety, and cost. Based on the evaluation of the data used to develop the conceptual site model; a review of past, current, and future operations at the site; and the detailed

The role of function analysis in the ACR control centre design

International Nuclear Information System (INIS)

Leger, R.P.; Davey, E.C.

2006-01-01

An essential aspect of control centre design is the need to characterize: plant functions and their inter-relationships to support the achievement of operational goals, and roles for humans and automation in sharing and exchanging the execution of functions across all operational phases. Function analysis is a design activity that has been internationally accepted as an approach to satisfy this need. It is recognized as a fundamental and necessary component in the systematic approach to control centre design and is carried out early in the design process. A function analysis can provide a clear basis for: the control centre design for the purposes of design team communication, and customer or regulatory review, the control centre display and control systems, the staffing and layout requirements of the control centre, assessing the completeness of control centre displays and controls prior and supplementary to mock-up walkthroughs or simulator evaluations, and the design of operating procedures and training programs. This paper will explore the role for function analysis in supporting the design of the control centre. The development of the ACR control room will be used as an illustrative context for the discussion. The paper will also discuss the merits of using function analysis in a goal-or function-based approach resulting in a more robust, operationally compatible, and cost-effective design over the life of the plant. Two former papers have previously outlined, the evolution in AECL's application approach and lessons learned in applying function analysis in support of control room design. This paper provides the most recent update to this progression in application refinement. (author)

The provisional ACR/EULAR definition of remission in RA: a comment on the patient global assessment criterion

NARCIS (Netherlands)

Vermeer, M.; Kuper, Hillechina H.; van der Bijl, Arie E.; Baan, H.; Posthumus, Marcel D.; Brus, Herman L.M.; van Riel, Piet L.C.M.; van de Laar, Mart A F J

2012-01-01

Objectives. The provisional ACR/European League Against Rheumatism (EULAR) definition of remission in RA requires a score of ≤1 on the patient global assessment (PGA, 0–10 scale). We explored the relation between the PGA criterion and the patient's clinical disease state in an observational dataset.

Naval Petroleum and Oil Shale Reserves

International Nuclear Information System (INIS)

1992-01-01

During fiscal year 1992, the reserves generated $473 million in revenues, a $181 million decrease from the fiscal year 1991 revenues, primarily due to significant decreases in oil and natural gas prices. Total costs were $200 million, resulting in net cash flow of $273 million, compared with $454 million in fiscal year 1991. From 1976 through fiscal year 1992, the Naval Petroleum and Oil Shale Reserves generated more than $15 billion in revenues and a net operating income after costs of $12.5 billion. In fiscal year 1992, production at the Naval Petroleum Reserves at maximum efficient rates yielded 26 million barrels of crude oil, 119 billion cubic feet of natural gas, and 164 million gallons of natural gas liquids. From April to November 1992, senior managers from the Naval Petroleum and Oil Shale Reserves held a series of three workshops in Boulder, Colorado, in order to build a comprehensive Strategic Plan as required by Secretary of Energy Notice 25A-91. Other highlights are presented for the following: Naval Petroleum Reserve No. 1--production achievements, crude oil shipments to the strategic petroleum reserve, horizontal drilling, shallow oil zone gas injection project, environment and safety, and vanpool program; Naval Petroleum Reserve No. 2--new management and operating contractor and exploration drilling; Naval Petroleum Reserve No. 3--steamflood; Naval Oil Shale Reserves--protection program; and Tiger Team environmental assessment of the Naval Petroleum and Oil Shale Reserves in Colorado, Utah, and Wyoming

Detection of potential AcrAB-TolC multidrug efflux pump inhibitor in calyces extract of Hibiscus sabdariffa

Directory of Open Access Journals (Sweden)

Nehaya Al-Karablieh

2017-12-01

Full Text Available Aim: The aim of this study is to investigate occurrence of potential efflux pump inhibitor (EPI against AcrAB-TolC efflux pump in the methanol extract of H. sabdariffa. Materials and Methods: Calyces of H. sabdariffa were purchased from the local market in April 2014, methanol extract of H. sabdariffa was subjected to agar plate diffusion against Escherichia coli TG1 and its ∆acrB-∆tolC and thin layer chromatography (TLC bioassay. The corresponding EPI fraction was eluted by methanol. The synergistic effect of antimicrobials and EPI fraction was measured by minimum inhibitory concentration (MIC determination for E. coli and Erwinia amylovora strains, and the ability of EPI fraction to enhance EtBr accumulation was conducted. Results: E. coli TG1 was more sensitive to the methanol extracts of H. sabdariffa than E. coli ∆acrB-∆tolC, and inhibition zone corresponding to flavones on TLC bioassay plate has been formed which might be related to the fraction of potential EPI. The MIC values revealed that EPI fraction enhanced the activity of the used antimicrobials by 4 to 8 folds in E. coli TG1 and by 4 to 10 folds in E. amylovora 1189. Addition of EPI fraction in a dose-dependent manner increased the intercellular accumulation of Ethidium Bromide (EtBr in the wild type stains of E. coli TG1 and E. amylovora 1189. Conclusion: EPI fraction behaves like a multidrug efflux pump inhibitor and further investigation should be conducted for determination of the chemical structure of EPI fraction. [J Complement Med Res 2017; 6(4.000: 357-363

Stress Introduction Rate Alters the Benefit of AcrAB-TolC Efflux Pumps.

Science.gov (United States)

Langevin, Ariel M; Dunlop, Mary J

2018-01-01

Stress tolerance studies are typically conducted in an all-or-none fashion. However, in realistic settings-such as in clinical or metabolic engineering applications-cells may encounter stresses at different rates. Therefore, how cells tolerate stress may depend on its rate of appearance. To address this, we studied how the rate of stress introduction affects bacterial stress tolerance by focusing on a key stress response mechanism. Efflux pumps, such as AcrAB-TolC of Escherichia coli , are membrane transporters well known for the ability to export a wide variety of substrates, including antibiotics, signaling molecules, and biofuels. Although efflux pumps improve stress tolerance, pump overexpression can result in a substantial fitness cost to the cells. We hypothesized that the ideal pump expression level would involve a rate-dependent trade-off between the benefit of pumps and the cost of their expression. To test this, we evaluated the benefit of the AcrAB-TolC pump under different rates of stress introduction, including a step, a fast ramp, and a gradual ramp. Using two chemically diverse stresses, the antibiotic chloramphenicol and the jet biofuel precursor pinene, we assessed the benefit provided by the pumps. A mathematical model describing these effects predicted the benefit as a function of the rate of stress introduction. Our findings demonstrate that as the rate of introduction is lowered, stress response mechanisms provide a disproportionate benefit to pump-containing strains, allowing cells to survive beyond the original inhibitory concentrations. IMPORTANCE Efflux pumps are ubiquitous in nature and provide stress tolerance in the cells of species ranging from bacteria to mammals. Understanding how pumps provide tolerance has far-reaching implications for diverse fields, from medicine to biotechnology. Here, we investigated how the rate of stressor appearance impacts tolerance. We focused on two distinct substrates of AcrAB-TolC efflux pumps, the

An empirical analysis of the dynamic programming model of stockpile acquisition strategies for China's strategic petroleum reserve

International Nuclear Information System (INIS)

Wu, Gang; Fan, Ying; Wei, Yi-Ming; Liu, Lan-Cui

2008-01-01

The world's future oil price is affected by many factors. The challenge, therefore, is how to select optimal stockpile acquisition strategies to minimize the cost of maintaining a reserve. This paper provides a new method for analyzing this problem using an uncertain dynamic programming model to analyze stockpile acquisition strategies for strategic petroleum reserve. Using this model, we quantify the impact of uncertain world oil price on optimal stockpile acquisition strategies of China's strategic petroleum reserve for the period 2007-2010 and 2011-2020. Our results show that the future stockpile acquisition is related to oil prices and their probability and, if not considering the occurrence of oil supply shortage, China should at least purchase 25 million barrels when world oil price is at an optimal level. The optimal price of stockpile acquisition of every year has a stronger relationship with the probability of high price; and the optimal expected price and size of stockpile acquisition is different in each year. (author)

Quantification of aluminium in soil of the Solimões Formation, Acre State, Brazil

Directory of Open Access Journals (Sweden)

Thiago Andrade Bernini

2013-12-01

Full Text Available The variety of soils in the State of Acre is wide and their chemical profiles are still not fully understood. The nature of the material of origin of these soils is indicated by the high aluminium (Al content, commonly associated with high calcium (Ca and magnesium (Mg contents. The study objective was to use different methods to quantify Al in soils from toposequences formed from material of a sedimentary nature originating from the Solimões Formation, in Acre, Brazil. Trenches were opened at three distinct points in the landscape: shoulder, backslope and footslope positions. Soil samples were collected for physical, chemical, mineralogical analyses. The Al content was quantified using different methods. High Al contents were found in most of these horizons, associated with high Ca and Mg levels, representing the predominant cations in the sum of exchangeable bases. The mineralogy indicates that the soils are still in a low weathering phase, with the presence of significant quantities of 2:1 minerals. Similar Al contents were determined by the methods of NaOH titration, xylenol orange spectrometry and inductively coupled plasma optical emission spectrometry. However, no consistent data were obtained by the pyrocatechol violet method. Extraction with KCl overestimated the exchangeable Al content due to its ability to extract the non-exchangeable Al present in the smectite interlayers. It was observed that high Al contents are related to the instability of the hydroxyl-Al smectite interlayers.

Naval Reserve Annual Operating Costs

Science.gov (United States)

1975-10-29

C. c ) CPi i 0 0 00 0 le C C.C~r In 1]1 In 00 It .- I to C-38 ’U2 WIX ’W~ - m u. -C-LC m4 C v , v ul FA ?w % -D 1 o r cl jc j, II t %c oK W)i Ir of... platform programs, while Program 11 contains 26 sub-programs each having a separate Reserve program sponsor. The distribution of Program 11 resources is...a mix of specific skills required to bring an active Navy oper-Iating platform to organizational manning. Each SRU is tailored to a specific ship

Actionable findings and the role of IT support: report of the ACR Actionable Reporting Work Group.

Science.gov (United States)

Larson, Paul A; Berland, Lincoln L; Griffith, Brent; Kahn, Charles E; Liebscher, Lawrence A

2014-06-01

The ACR formed the Actionable Reporting Work Group to address the potential role of IT in the communication of imaging findings, especially in cases that require nonroutine communication because of the urgency of the findings or their unexpected nature. These findings that require special communication with referring clinicians are classified as "actionable findings." The work group defines 3 categories of actionable findings that require, respectively, communication and clinical decision within minutes (category 1), hours (category 2), or days (category 3). Although the work group does not believe that there can be definitive lists of such findings, it developed lists in each category that would apply in most general hospital settings. For each category, the work group discusses ways in which IT can assist interpreting radiologists in successfully communicating to the relevant clinicians to ensure optimal patient care. IT systems can also help document the communication and facilitate auditing of the documentation. The work group recommends that vendors develop platforms that can be customized on the basis of local preferences and needs. Whatever system is used, it should be highly reliable and fit seamlessly into radiologists' workflow. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Análise da degradação ambiental na Amazônia Ocidental: um estudo de caso dos municípios do Acre

Directory of Open Access Journals (Sweden)

Rubicleis Gomes da Silva

2004-01-01

Full Text Available Os resultados gerais divulgados pelo relatório final do GOVERNO DO ESTADO DO ACRE (2000 mostraram que parte da região sudeste do Estado do Acre vem sendo modificada há algumas décadas por um processo de ocupação iniciado por desflorestamentos e atividades agropecuárias. Segundo este relatório, o desmatamento e a queima da vegetação por atividades humanas foram as grandes transformadoras das paisagens acreanas e continuam a crescer muito nas últimas décadas. Diante do exposto, o objetivo principal deste trabalho foi elaborar um Índice de Degradação (ID que fosse capaz de medir o atual estágio de degradação ambiental em que se encontram os 22 municípios do Estado do Acre, na região norte do Brasil, procurando, também, agrupá-los em clusters para verificar características semelhantes entre eles. Os resultados indicam que o Estado do Acre possui um ID médio de 30,74%, possuindo como ID´s mínimos os municípios de Cruzeiro do Sul e Mâncio Lima com ID igual a zero e Manoel Urbano com um ID de 1,80%. A análise de cluster mostrou que determinadas regiões possuem um bom estado de conservação ambiental, no entanto, também deixou claro que alguns indicadores de degradação apresentam valores extremamente elevados.The general results disclosed by the State of Acre's final report (2000 showed that part of the Southeast area of the State has been modified for some decades by an occupation process triggered by deforestation and agricultural and cattle raising activities. According to this report, deforestation and burning of vegetation by human activities were the major transformers of the State landscapes and have increased in the last decades. Therefore, the main purpose of this work was to develop a Degradation Index (DI that would measure the current stage of environmental degradation of the 22 municipalities of State of Acre in the North region of Brazil also attempting to group them in clusters to verify similar

40 CFR 147.502 - Aquifer exemptions. [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Aquifer exemptions. [Reserved] 147.502... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Florida § 147.502 Aquifer exemptions. [Reserved] ...

The Strategic Petroleum Reserve: United States energy security, oil politics, and petroleum reserves policies in the twentieth century

Science.gov (United States)

Beaubouef, Bruce Andre

The history of U.S. petroleum reserves policies in the twentieth century, including the Strategic Petroleum Reserve (SPR) program, provides a case study of the economic and political aspects of national security, and shows the ways in which the American political economy influences national security. One key problem plagued federal petroleum reserve programs and proposals throughout the twentieth century. In a political economy which traditionally placed strong emphasis upon the sanctity of private property and free markets, could the government develop an emergency petroleum reserve policy despite opposition from the private sector? Previous literature on the SPR and oil-stockpiling programs has largely disregarded the historical perspective, focusing instead upon econometric models, suggesting future oil-stockpiling policy options. This study will also make conclusions about the future of governmental oil-stockpiling policies, particularly with regard to the SPR program, but it will do so informed by a systematic history of the emergency petroleum reserve impulse in the twentieth century. Through a study of the emergency petroleum reserve impulse, one can see how the American political economy of oil and energy changed over the twentieth century. As petroleum became crucial to the military and then economic security of the United States, the federal government sought to develop emergency petroleum reserves first for the military, then for the civilian economy. But while the American petroleum industry could deliver the energy "goods" to American energy consumers at a reasonable price, the companies reigned supreme in the political equation. While that was true, federal petroleum reserve programs and proposals conflicted with and were overwhelmed by the historic American tradition of individual economic and private property rights. The depletion of American petroleum reserves changed that political equation, and the ensuing energy crises of the 1970s not only

24 CFR 206.115 - [Reserved

Science.gov (United States)

2010-04-01

... MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums § 206.115 [Reserved] ...

Nota sobre culicídeos (Diptera: Culicidae da bacia do rio Purus, Acre, Amazônia (Brasil

Directory of Open Access Journals (Sweden)

Natal Delsio

1992-01-01

Full Text Available Foram feitas coletas de mosquito (Diptera: Culicidae na área do projeto de Colonização Pedro Peixoto, no Estado do Acre, Brasil. Obteve-se um total de 4.588 exemplares pertencentes a 53 espécies ou grupos. Salienta-se a ocorrência de Anopheles (Nyssorhynchus oswaldoi.

Nota sobre culicídeos (Diptera: Culicidae da bacia do rio Purus, Acre, Amazônia (Brasil

Directory of Open Access Journals (Sweden)

Delsio Natal

1992-04-01

Full Text Available Foram feitas coletas de mosquito (Diptera: Culicidae na área do projeto de Colonização Pedro Peixoto, no Estado do Acre, Brasil. Obteve-se um total de 4.588 exemplares pertencentes a 53 espécies ou grupos. Salienta-se a ocorrência de Anopheles (Nyssorhynchus oswaldoi.

Genetic diversity of "Pimenta Longa" genotypes (Piper spp., Piperaceae of the Embrapa Acre germplasm collection

Directory of Open Access Journals (Sweden)

Lúcia Helena de Oliveira Wadt

2004-01-01

Full Text Available The commonly known Pimenta longa is a commercially valuable natural resource found wild in Acre, Brazil. Specifically, three Piperaceae species with contested taxonomic status were studied, Piper hispidinervum, Piper aduncum, and Piper hispidum, to assesses the inter- and intra-specific genetic relationship of 49 Piper genotypes kept in the Pimenta longa germplasm collection at Embrapa Acre, using sixty six Random Amplified Polymorphic DNA (RAPD markers. The DNA polymorphism level detected was high (96.97%, but the marker frequencies for each species showed polymorphism levels of 79.4% for Piper hispidinervum and 5.3% for P. aduncum. The genetic similarity clustering analysis resulted in three distinct groups corresponding to Piper hispidinervum, Piper aduncum, and Piper hispidum. Four and nine characteristic RAPD markers were identified for P. hispidinervum and P. aduncum, respectively, supporting the existence of two separate species. However, six genotypes collected in Tarauacá county formed a distinct subgroup within the P. hispidinervum group and may be considered as an ecotype of this species or an intermediate between the P. hispidinervum and P. aduncum groups. More extensive sampling of both P. hispidinervum and P. aduncum populations throughout the region are needed to further establish their relation and its implication for breeding efforts.

75 FR 6539 - Healthy Forests Reserve Program

Science.gov (United States)

2010-02-10

... producers who are members of the protected groups have participated in NRCS conservation programs at parity... between the Federal Government and the States, or on the distribution of power and responsibilities on the... is not necessary and may create confusion. NRCS removed the term ``option agreement to purchase...

Gas supply for independent power projects: Drilling programs and reserve acquisitions

International Nuclear Information System (INIS)

Lambert, J.D.; Walker, R.K.

1990-01-01

Developers of gas-fired independent power projects, although drawn to gas as the fuel of choice for economic and environmental reasons, are finding the problem of cost-effective gas supply to be intractable. By one estimate, there are $6 billion worth of gas-fired projects languishing in the planning stage for want of long-term gas supply that is acceptable to project lenders. Worse still, as the authors are aware, some currently operating gas-fired projects lack such a supply, thus forcing the developer to rely on the spot market for gas as an interim (and unsatisfactory) solution. Although spot market prices in the deregulated natural gas industry have remained relatively low over several years, long-term gas supply has become problematic, particularly for power projects whose economics typically require an assured supply at a determined price over a multiyear period. In short, while there is an increasing demand for gas as a preferred source of fuel supply for power projects, there are discontinuities in the approaches taken to contracting for that supply by producers and developers. These concern primarily allocation of the risk of commodity-driven price increases during the term of the fuel supply contract. Without a means of accommodating price-related risk, the parties will inevitably find themselves at an impasse in contract negotiations. If there is a barrier to the independent power generation industry's vertical integration into gas production, it is the fundamental insularity of the two industries. As they have discovered, it may be indispensable for gas producers and power developers to employ intermediaries familiar with both industries in order to consummate appropriate joint-venture drilling programs and reserve acquisitions. Given the economic consequences of doing so successfully, however, they believe such programs and acquisitions may become an integral part of independent power developers' business strategy in the 1990s and beyond

Avaliação de genótipos de cafeeiros Arabica e Robusta no estado do Acre Evaluation of Arabica and Robusta coffee genotypes in the state of Acre

Directory of Open Access Journals (Sweden)

Celso Luis Bergo

2008-02-01

Full Text Available Conduziu-se este trabalho, com o objetivo de introduzir e avaliar 40 genótipos de cafeeiros das espécies Coffea arabica e Coffea canephora nas condições edafoclimáticas do Estado do Acre, visando disponibilizar aos cafeicultores acreanos, cultivares com melhor potencial produtivo. Da espécie C. arabica foram avaliados genótipos das cultivares Icatu, Bourbon, Mundo Novo, Catuaí, Obatã e Catimor. Da espécie C. canephora foram avaliadas as cultivares Conilon e Robusta, caracterizadas como Grupo Robusta. Os genótipos utilizados foram provenientes do Instituto Agronômico de Campinas (IAC e da Embrapa Rondônia. O experimento foi conduzido no Campo Experimental da Embrapa Acre, Rio Branco, AC, no período de 1995 a 2004. O delineamento experimental foi em blocos casualizados com cinco repetições. As características avaliadas foram: produtividade, altura, diâmetro da copa e vigor. Da espécie C. arabica, grupo Icatu, destacou-se Icatu-PR-182039-1(IAC H 4782-7-788 com produtividade média de café beneficiado de 34 sc/ ha, Icatu IAC-4041; Icatu IAC-2945; Icatu IAC-2944-MT; Icatu IAC-4040 e Icatu IAC-4046 com produtividade variando de 20 a 26 sacas. Para o grupo Catuaí os melhores genótipos foram Obatã IAC 4275, Obatã IAC 1169 e Catimor IAC 4466 com produtividade média de café beneficiado de 49, 45 e 37 sacas por hectare respectivamente. Na espécie C. canephora foram avaliados 8 genótipos das cultivares Conilon e Robusta e quanto à produtividade não houve diferença estatística, observou-se incremento de 7 sacas/ha para a variedade Conilon IAC 66-3 quando comparado ao Conilon plantado na região. Nesta espécie os genótipos apresentaram sintomas de deficiência hídrica na época seca (julho/agosto.This work aimed to introduce and evaluate 40 coffee genotypes of Coffea arabica e Coffea canephora species in soil and weather conditions of Acre and had as main goal to provide cultivars to coffee producers with better potential of

77 FR 74697 - Meeting of the ACRS, Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting

Science.gov (United States)

2012-12-17

..., Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on January 17, 2013, Room T-2B1, 11545 Rockville Pike... be made. Thirty-five hard copies of each presentation or handout should be provided to the DFO thirty...

FY 1994 annual summary report of the surveillance and maintenance activities for the Oak Ridge National Laboratory Environmental Restoration Program

International Nuclear Information System (INIS)

1994-11-01

The Oak Ridge National Laboratory (ORNL) Environmental Restoration (ER) Surveillance and Maintenance (S and M) Program was initiated to manage former waste management and environmental research sites contaminated with radioactive materials and/or hazardous chemicals. The S and M Program is responsible for managing designated sites/facilities from the end of their operating lives until final disposition or site stabilization. To effectively manage and perform the various S and M Program responsibilities, five summary-level work breakdown structure (WBS) elements have been established: S and M Preliminary Investigations, Special Projects, Routine S and M, Inactive Groundwater Wells, and Project Management. Routine S and M activities were conducted as scheduled throughout fiscal years (FY) 1994 at applicable inactive waste management (WM) and other contaminated areas. Overall, the ER S and M Program maintains 47 facilities, performs vegetation maintenance on approximately 230 acres, maintains 54 inactive tanks, and provides overall site management on over 700 acres. In addition to the routine S and M activities, detailed site inspections were conducted at established frequencies on appropriate sites in the ER S and M Program. This document provides a summary of the FY 1994 ORNL ER S and M Program accomplishments

American Society for Radiation Oncology (ASTRO) and American College of Radiology (ACR) Practice Guideline for the Performance of High-Dose-Rate Brachytherapy

International Nuclear Information System (INIS)

Erickson, Beth A.; Demanes, D. Jeffrey; Ibbott, Geoffrey S.; Hayes, John K.; Hsu, I-Chow J.; Morris, David E.; Rabinovitch, Rachel A.; Tward, Jonathan D.; Rosenthal, Seth A.

2011-01-01

High-Dose-Rate (HDR) brachytherapy is a safe and efficacious treatment option for patients with a variety of different malignancies. Careful adherence to established standards has been shown to improve the likelihood of procedural success and reduce the incidence of treatment-related morbidity. A collaborative effort of the American College of Radiology (ACR) and American Society for Therapeutic Radiation Oncology (ASTRO) has produced a practice guideline for HDR brachytherapy. The guideline defines the qualifications and responsibilities of all the involved personnel, including the radiation oncologist, physicist and dosimetrists. Review of the leading indications for HDR brachytherapy in the management of gynecologic, thoracic, gastrointestinal, breast, urologic, head and neck, and soft tissue tumors is presented. Logistics with respect to the brachytherapy implant procedures and attention to radiation safety procedures and documentation are presented. Adherence to these practice guidelines can be part of ensuring quality and safety in a successful HDR brachytherapy program.

75 FR 27114 - Public Transportation on Indian Reservations Program; Tribal Transit Program

Science.gov (United States)

2010-05-13

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Public Transportation on Indian..., 2005)] amended 49 U.S.C. 5311(c) by establishing the Public Transportation on Indian Reservations... Census and may be used for public transportation capital projects, operating costs of equipment and...

Evapotranspiration Cover for the 92-Acre Area Retired Mixed Waste Pits, Area 5 Waste Management Division, Nevada National Security Site, Final CQA Report

International Nuclear Information System (INIS)

2012-01-01

The report is the Final Construction Quality Assurance (CQA) Report for the 92-Acrew Evapotranspiration Cover, Area 5 Waste Management Division Retired Mixed Waste Pits, Nevada National Security Site, Nevada, for the period of January 20, 2011, to January 31, 2012 The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste. The 92-Acre Area encompasses the southern portion of the Area 5 RWMS, which has been designated for the first final closure operations. This area contains 13 Greater Confinement Disposal (GCD) boreholes, 16 narrow trenches, and 9 broader pits. With the exception of two active pits (P03 and P06), all trenches and pits in the 92-Acre Area had operational covers approximately 2.4 meters thick, at a minimum, in most areas when this project began. The units within the 92-Acre Area are grouped into the following six informal categories based on physical location, waste types and regulatory requirements: (1) Pit 3 Mixed Waste Disposal Unit (MWDU); (2) Corrective Action Unit (CAU) 111; (3) CAU 207; (4) Low-level waste disposal units; (5) Asbestiform low-level waste disposal units; and (6) One transuranic (TRU) waste trench.

Logging Activity in the Trinational Amazonian Region of Pando/Bolivia, Acre and Rond“nia/Brazil, and Madre de Dios/Peru: Analysis of Existing Data

Science.gov (United States)

Mendoza, E.; Brilhante, S. H.; Brown, I.; Peralta, R.; Rivero, S.; Melendez, N.

2002-12-01

Logging activity in the trinational southwestern Amazonia will grow in importance as a driver of regional land-use change as expanding road access facilitates both timber extraction and transport to international markets. Official data on current activity in this ~50 million ha region are limited and inconsistent with differences as much as twenty-fold between official estimates; nevertheless, they serve as guides for understanding the relative magnitude of logging activities. For 2000, an estimated 5 million m3 of timber were commercialized in Rondonia, 400,000 m3 in Acre, Brazil, and 200,000 m3 for the combined departments of Pando, Bolivia and Madre de Dios, Peru. About 70% of this timber originates from clear cutting done for pasture and agriculture activities, nearly a third from unregulated selective logging, and only 2% from managed selective logging. Eight timber species are preferentially extracted. The total area for timber concessions in Acre, Pando and Madre de Dios extends to about 4 million ha for a potential timber supply of 65 million m3. About 150,000 m3/yr of illegal timber is confiscated by federal and state agencies in Acre, Pando and Madre de Dios. Problems of enforcement in the region are due principally to the lack of trained personnel and little cooperation among agencies of the three countries. Proposed development plans indicate a 3- to >10-fold increase in logging activity in the Acre and Pando regions during the coming decade. More detailed studies are urgently needed to guide sustainable development of this resource in southwestern Amazonia.

7 CFR 1735.23-1735.29 - [Reserved

Science.gov (United States)

2010-01-01

... AGRICULTURE GENERAL POLICIES, TYPES OF LOANS, LOAN REQUIREMENTS-TELECOMMUNICATIONS PROGRAM Loan Purposes and Basic Policies §§ 1735.23-1735.29 [Reserved] ... 7 Agriculture 11 2010-01-01 2010-01-01 false [Reserved] 1735.23-1735.29 Section 1735.23-1735.29...

40 CFR 73.27 - Special allowance reserve.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Special allowance reserve. 73.27 Section 73.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations § 73.27 Special allowance reserve. (a...

40 CFR 73.22-73.24 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 73.22-73.24 Section 73.22-73.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations §§ 73.22-73.24 [Reserved] ...

40 CFR 73.14-73.17 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 73.14-73.17 Section 73.14-73.17 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations §§ 73.14-73.17 [Reserved] ...

45 CFR 400.6 - [Reserved

Science.gov (United States)

2010-10-01

... Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Grants to States for Refugee Resettlement The State Plan § 400.6 [Reserved] ...

Honey quality of Melipona sp. bees in Acre, Brazil

Directory of Open Access Journals (Sweden)

Marcus Augusto Damaceno do Vale

2018-04-01

Full Text Available Honey from stingless bees (Melipona sp. is a nutritious and medicinal product economically valued in the informal Brazilian market, driven by the growing demand for natural products; however, its physicochemical characteristics are still unknown. Thus, the aim of this study is to evaluate the physicochemical profile of the stingless bee honey produced in Cruzeiro do Sul, Acre. Honey samples were analyzed following the methodology recommended by Ministério da Agricultura, Pecuária e Abastecimento; the following parameters were established: moisture, total sugars, reducing sugars, apparent sucrose, ash, crude protein, diastase activity, Brix degrees, free acidity, lactonic acidity, total acidity, pH, hydroxymethylfurfural, electrical conductivity, color and Lugol, Lund and Fiehe reactions. Results show that these parameters are not suitable for all samples, being incompatible with established standards, indicating that the current legislation on Apis mellifera is not suitable for all characters analyzed, mainly moisture content, corroborating the need to standardize guidelines for honey from stingless bees. Moreover, there was no tampering in the honeys analyzed.

76 FR 19783 - Draft Environmental Impact Statement for the Proposed Pueblo of Jemez 70.277-Acre Fee-to-Trust...

Science.gov (United States)

2011-04-08

.... Environmental Protection Agency (EPA) for the proposed approval of a 70.277 acre fee-to-trust transfer and..., location, and areas of environmental concern addressed in the DEIS are provided in the SUPPLEMENTARY..., Bureau of Indian Affairs, Southwest Regional Office, 1001 Indian School Road, NW., Albuquerque, New...

Summary of the ACRE inaugural meeting.

Science.gov (United States)

Bloomgarden, Zachary T

2009-01-01

The charter meeting of the Association of Clinical Researchers and Educators (ACRE) provided a powerful set of arguments against assertions that physician-industry collaboration is harmful and represents a "conflict of interest." Such collaboration has, in fact, improved medical care for patients, a case made overwhelmingly by patients and patient advocacy groups at the meeting. The contentions that physician-industry collaboration is problematic are not based on evidence. They depend on unjustified generalization from inevitable, sometimes egregious, but vanishingly uncommon adverse outcomes of industry-physician interaction without reference to how so much more commonly these interactions add value. Furthermore, the claim that physician-industry collaboration is unprofessional is refuted by rational scrutiny. Indeed, the term "conflict of interest" itself is vague, inviting subjectivity and deserving to be rejected. The unwarranted success of conflict of interest regulation has prevailed because of the failure of physicians, educators, and innovators, through apathy and intimidation, to pay attention to its fallacies and resist its dangers. It has arisen from activist ambitions and from misalignment between the purposes of medical practitioners, educators, and innovators and those of administrators in medical journals and in academic medical centers. The media and politicians have not appreciated these misalignments and have accepted conflict of interest arguments at face value. Regulation emanating from conflict of interest criticism is confusing, onerous, expensive, disrespectful, and damaging. Prohibitions against speaking about medical products inhibit physician and patient education concerning rapidly emerging and complex therapies. Input by physicians cognizant of compliance requirements into such presentations should be encouraged. Restrictions to the free flow of corporate support of academic health centers, professional societies, and patient

40 CFR 272.2050-272.2099 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false [Reserved] 272.2050-272.2099 Section 272.2050-272.2099 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS South Carolina §§ 272.2050-272.2099 [Reserved] ...

First emergence of acrAB and oqxAB mediated tigecycline resistance in clinical isolates of Klebsiella pneumoniae pre-dating the use of tigecycline in a Chinese hospital.

Directory of Open Access Journals (Sweden)

Xue Zhong

Full Text Available Tigecycline is one of the few therapeutic options for treating infections caused by some multi-drug resistant pathogens, such as Klebsiella pneumoniae. However, tigecycline-resistant K. pneumoniae has been discovered recently in China. From 2009 to 2013, nine tigecycline-resistant K. pneumoniae isolates were identified in our hospital. Six of nine strains were identified before using tigecycline. To investigate the efflux-mediated resistance mechanisms of K. pneumoniae, the expression of efflux pump genes (acrA, acrB, tolC, oqxA and oqxB and pump regulators (acrR, marA, soxS, rarA, rob and ramA were examined by real-time RT-PCR. Molecular typing of the tigecycline resistant strains was performed. ST11 was the predominant clone of K. pneumoniae strains, while ST1414 and ST1415 were novel STs. Efflux pump inhibitor (EPI-carbonyl cyanide chlorophenylhydrazone (CCCP was able to reverse the resistance patterns of 5 resistant K. pneumoniae strains. In comparison with strain A111, a tigecycline-susceptible strain (negative control, we found that the expression levels of efflux pump genes and pump regulators were higher in a majority of resistant strains. Higher expression levels of regulators rarA (2.41-fold, 9.55-fold, 28.44-fold and 18.31-fold, respectively and pump gene oqxB (3.87-fold, 31.96-fold, 50.61-fold and 29.45-fold, respectively were observed in four tigecycline resistant strains (A363, A361, A368, A373, respectively. Increased expression of acrB was associated with ramA and marA expression. To our knowledge, studies on tigecycline resistance mechanism in K. pneumoniae are limited especially in China. In our study, we found that both efflux pump AcrAB-TolC and OqxAB contributed to tigecycline resistance in K. pneumoniae isolates.

USGS considers moving Menlo Park programs

Science.gov (United States)

Showstack, Randy

U.S. Interior Secretary Bruce Babbitt has instructed the U.S. Geological Survey to examine options to relocate staff and programs at the agency's 16-acre Menlo Park Facilities within 5 years. The agency was directed on August 21 to submit a preliminary action plan by September 25.A memo from USGS Director Gordon Eaton states that Babbitt is concerned about high real estate costs in the Menlo Park area and the need for the agency to locate near other Interior and federal offices.

MOLECULAR CHARACTERIZATION OF AMERICAN CUTANEOUS LEISHMANIASIS IN THE TRI‑BORDER AREA OF ASSIS BRASIL, ACRE STATE, BRAZIL

Directory of Open Access Journals (Sweden)

Carolina Bioni Garcia TELES

2015-08-01

Full Text Available SUMMARY In this study, Leishmaniaspecies were identified by Polymerase Chain Reaction (PCR. The epidemiology of patients suspected of having American Cutaneous Leishmaniasis in the municipality of Assis Brasil, Acre State, located in the Brazil/Peru/Bolivia triborder was also investigated. By PCR, the DNA of Leishmaniawas detected in 100% of the cases (37 samples and a PCR-Restriction Fragment Length Polymorphism (RFLP of the hsp 70gene identified the species in 32 samples: Leishmania (Viannia braziliensis (65.6% , L. (V. shawi (28.1% , L. (V. guyanensis (3.1% and mixed infection L. (V. guyanensis and L. (Leishmania amazonensis (3.1%This is the first report of L. (V. shawiand L. (L. amazonensis in Acre. The two predominant species were found in patients living in urban and rural areas. Most cases were found in males living in rural areas for at least three years and involved in rural work. This suggests, in most cases, a possible transmission of the disease from a rural/forest source, although some patients had not engaged in activities associated with permanence in forestall areas, which indicate a possible sandflies adaptation to the periurban setting.

Stockpile strategy for China's emergency oil reserve: A dynamic programming approach

International Nuclear Information System (INIS)

Bai, Y.; Dahl, C.A.; Zhou, D.Q.; Zhou, P.

2014-01-01

China is currently accelerating construction of its strategic petroleum reserves. How should China fill the SPR in a cost-effective manner in the short-run? How might this affect world oil prices? Using a dynamic programming model to answer these questions, the objective of this paper is to minimize the stockpiling costs, including consumer surplus as well as crude acquisition and holding costs. The crude oil acquisition price in the model is determined by global equilibrium between supply and demand. Demand, in turn, depends on world market conditions including China's stockpile filling rate. Our empirical study under different market conditions shows that China's optimal stockpile acquisition rate varies from 9 to 19 million barrels per month, and the optimal stockpiling drives up the world oil price by 3–7%. The endogenous price increase accounts for 52% of total stockpiling costs in the base case. When the market is tighter or the demand function is more inelastic, the stockpiling affects the market more significantly and pushes prices even higher. Alternatively, in a disruption, drawdown from the stockpile can effectively dampen soaring prices, though the shortage is likely to leave the price higher than before the disruption. - Highlights: • China's SPR policies are examined by dynamic programming. • The optimal stockpile acquisition rate varies from 9 to 19 million barrels per month. • The optimal stockpiling drives up world oil price by 3–7%

A model based on stochastic dynamic programming for determining China's optimal strategic petroleum reserve policy

International Nuclear Information System (INIS)

Zhang Xiaobing; Fan Ying; Wei Yiming

2009-01-01

China's Strategic Petroleum Reserve (SPR) is currently being prepared. But how large the optimal stockpile size for China should be, what the best acquisition strategies are, how to release the reserve if a disruption occurs, and other related issues still need to be studied in detail. In this paper, we develop a stochastic dynamic programming model based on a total potential cost function of establishing SPRs to evaluate the optimal SPR policy for China. Using this model, empirical results are presented for the optimal size of China's SPR and the best acquisition and drawdown strategies for a few specific cases. The results show that with comprehensive consideration, the optimal SPR size for China is around 320 million barrels. This size is equivalent to about 90 days of net oil import amount in 2006 and should be reached in the year 2017, three years earlier than the national goal, which implies that the need for China to fill the SPR is probably more pressing; the best stockpile release action in a disruption is related to the disruption levels and expected continuation probabilities. The information provided by the results will be useful for decision makers.

Review and evaluation of the Nuclear Regulatory Commission safety research program for Fiscal Year 1983. Report to the Congress

International Nuclear Information System (INIS)

1982-02-01

Public Law 95-209 includes a requirement that the Advisory Committee on Reactor Safeguards submit an annual report to Congress on the safety research program of the Nuclear Regulatory Commission. This report presents the results of the ACRS review and evaluation of the NRC safety research program for Fiscal Year 1983. The report contains a number of comments and recommendations

45 CFR 400.10 - [Reserved

Science.gov (United States)

2010-10-01

... Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Grants to States for Refugee Resettlement The State Plan § 400.10 [Reserved] Award of Grants to States ...

User's guide for the Uranium Ore Reserve Calculation System (URAD)

International Nuclear Information System (INIS)

1988-12-01

The URAD (Uranium Reserves and Data) system consists of four computer programs designed to facilitate the evaluation of uranium ore reserves analysis and the handling of basic uranium assay data. URAD is designed specifically as a training tool for anyone unfamiliar with the methodology, data requirements, and/or general computer applications in the field of uranium ore reserves analysis. However, it can effectively be used in a 'production' environment involving considerable amounts of data. The resulting programs are written in Microsoft FORTRAN (Version 3.1) and may be run on any IBM-compatible microcomputer under DOS 2.1 (or later). Only a basic working knowledge of DOS 2.1 is needed to maintain the system and run the programs. This guide includes the overview of the URAD system, the review of sample data and a complete description of the file structure and sample type formats of the basic sample data files. Program URDAT explains the initial processing of the primary UDAT files to obtain standard output listings and gamma-log interpretations of radiometric data, and to create intermediate UDAT files which are used by the ore reserves programs - RESUV, ORSAC, and SCOR. Figs and tabs

American Society for Radiation Oncology (ASTRO) and American College of Radiology (ACR) Practice Guideline for the Transperineal Permanent Brachytherapy of Prostate Cancer

International Nuclear Information System (INIS)

Rosenthal, Seth A.; Bittner, Nathan H.J.; Beyer, David C.; Demanes, D. Jeffrey; Goldsmith, Brian J.; Horwitz, Eric M.; Ibbott, Geoffrey S.; Lee, W. Robert; Nag, Subir; Suh, W. Warren; Potters, Louis

2011-01-01

Transperineal permanent prostate brachytherapy is a safe and efficacious treatment option for patients with organ-confined prostate cancer. Careful adherence to established brachytherapy standards has been shown to improve the likelihood of procedural success and reduce the incidence of treatment-related morbidity. A collaborative effort of the American College of Radiology (ACR) and American Society for Therapeutic Radiation Oncology (ASTRO) has produced a practice guideline for permanent prostate brachytherapy. The guideline defines the qualifications and responsibilities of all the involved personnel, including the radiation oncologist, physicist and dosimetrist. Factors with respect to patient selection and appropriate use of supplemental treatment modalities such as external beam radiation and androgen suppression therapy are discussed. Logistics with respect to the brachtherapy implant procedure, the importance of dosimetric parameters, and attention to radiation safety procedures and documentation are presented. Adherence to these practice guidelines can be part of ensuring quality and safety in a successful prostate brachytherapy program.

24 CFR 266.110 - Reserve requirements.

Science.gov (United States)

2010-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.110 Reserve requirements. (a) HFAs with top-tier designation or overall...

28 CFR 39.104-39.109 - [Reserved

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false [Reserved] 39.104-39.109 Section 39.104-39.109 Judicial Administration DEPARTMENT OF JUSTICE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF JUSTICE §§ 39.104-39.109 [Reserved] ...

28 CFR 39.141-39.148 - [Reserved

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false [Reserved] 39.141-39.148 Section 39.141-39.148 Judicial Administration DEPARTMENT OF JUSTICE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF JUSTICE §§ 39.141-39.148 [Reserved] ...

28 CFR 39.152-39.159 - [Reserved

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false [Reserved] 39.152-39.159 Section 39.152-39.159 Judicial Administration DEPARTMENT OF JUSTICE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF JUSTICE §§ 39.152-39.159 [Reserved] ...

28 CFR 39.131-39.139 - [Reserved

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2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false [Reserved] 39.131-39.139 Section 39.131-39.139 Judicial Administration DEPARTMENT OF JUSTICE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF JUSTICE §§ 39.131-39.139 [Reserved] ...

28 CFR 39.112-39.129 - [Reserved

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false [Reserved] 39.112-39.129 Section 39.112-39.129 Judicial Administration DEPARTMENT OF JUSTICE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF JUSTICE §§ 39.112-39.129 [Reserved] ...

28 CFR 39.161-39.169 - [Reserved

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false [Reserved] 39.161-39.169 Section 39.161-39.169 Judicial Administration DEPARTMENT OF JUSTICE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF JUSTICE §§ 39.161-39.169 [Reserved] ...

77 FR 60139 - Draft Environmental Impact Statement for the Proposed Pueblo of Jemez 70.277-Acre Fee-to-Trust...

Science.gov (United States)

2012-10-02

... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Draft Environmental Impact Statement for the... all work on an Environmental Impact Statement (EIS) for the BIA Federal action of approving a 70.277 acre fee-to-trust transfer and casino project located within Do[ntilde]a Ana County, New Mexico. DATES...

Measurement of superoxide dismutase-like activity in peel and pulp of apple from Anshan acres

Science.gov (United States)

Zhao, Lijuan

2018-04-01

Pyrogallol autoxidation method was used for measurement of SOD-like activity. They are 259.56 u/g and 148.78 u/g in peel and pulp of apple from Anshan acres. The proper-conditions for this measurement was determined through experiment as following: detection wavelength of spectrophotometer 325nm, buffer system Tris-HAc, concentration of Tris-HAc solution 50 mmoL and pH8.2. The inhibition rate of SOD-L again pyrogallol antioxidation are 92% and 90% in peel and pulp of apple.

Geohydrology and effects of water use in the Black Mesa area, Navajo and Hopi Indian Reservations, Arizona

Science.gov (United States)

Eychaner, James H.

1983-01-01

The N aquifer is the main source of water in the 5,400-square-mile Black Mesa area in the Navajo and Hopi Indian Reservations in northeastern Arizona. The N aquifer consists of the Navajo Sandstone and parts of the underlying Kayenta Formation and Wingate Sandstone of Jurassic and Triassic age. Maximum saturated thickness of the aquifer is about 1,050 feet in the northwestern part of the area, and the aquifer thins to extinction to the southeast. Water is under confined conditions in the central 3,300 square miles of the area. To the east, north, and west of Black Mesa, the aquifer is exposed at the surface, and water is unconfined. The aquifer was in equilibrium before about 1965. Recharge of about 13,000 acre-feet per year was balanced primarily by discharge near Moenkopi Wash and Laguna Creek and by evapotranspiration. At least 180 million acre-feet of water was in storage. The estimated average hydraulic conductivity of the aquifer is 0.65 foot per day. The confined storage coefficient is estimated to be about 0.0004 where the aquifer is thickest, and the estimated unconfined storage coefficient ranges from 0.10 to 0.15. Ground-water withdrawals that averaged 5,300 acre-feet per year from 1976 to 1979 have caused water levels to decline in wells in the confined part of the aquifer. Withdrawals include an average of 3,700 acre-feet per year to supply a coal-slurry pipeline from a coal mine on Black Mesa. Six observation wells equipped with water-level recorders have been used to monitor aquifer response. The water level in one well 32 miles south of the mine declined 17 feet from 1972 through 1979 and 3.5 feet during 1979. A mathematical model of the N aquifer was developed and calibrated for equilibrium and nonequilibrium conditions. The model was used in part to improve estimates of aquifer characteristics and the water budget, and it successfully reproduced the observed response of the aquifer through 1979. The model results indicate that about 95 percent of

49 CFR 28.152-28.159 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.152-28.159 Section 28.152-28.159 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.152-28.159 [Reserved] ...

49 CFR 28.171-28.999 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.171-28.999 Section 28.171-28.999 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.171-28.999 [Reserved] ...

49 CFR 28.132-28.139 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.132-28.139 Section 28.132-28.139 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.132-28.139 [Reserved] ...

49 CFR 28.161-28.169 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.161-28.169 Section 28.161-28.169 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.161-28.169 [Reserved] ...

49 CFR 28.141-28.148 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.141-28.148 Section 28.141-28.148 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.141-28.148 [Reserved] ...

49 CFR 28.104-28.109 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.104-28.109 Section 28.104-28.109 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.104-28.109 [Reserved] ...

49 CFR 28.112-28.129 - [Reserved

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 28.112-28.129 Section 28.112-28.129 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION §§ 28.112-28.129 [Reserved] ...

Aquatic Natural Areas Analysis and Evaluation: Oak Ridge Reservation

Energy Technology Data Exchange (ETDEWEB)

Baranski, Dr. Michael J. [Catawba College

2011-04-01

This report presents an assessment of the natural area value of eight Aquatic Natural Areas (ANAs) and seven Aquatic Reference Areas (ARAs) on the Oak Ridge Reservation (ORR) in Anderson and Roane Counties in east Tennessee. It follows a previous study in 2009 that analyzed and evaluated terrestrial natural areas on the Reservation. The purpose of both studies was to evaluate and rank those specially designated areas on the Reservation that contain sensitive species, special habitats, and natural area value. Natural areas receive special protections through established statutes, regulations, and policies. The ORR contains 33,542 acres (13,574 ha) administered by the Department of Energy. The surface waters of the Reservation range from 1st-order to 5th-order streams, but the majority of the streams recognized as ANAs and ARAs are 1st- and 2nd-order streams. East Fork Poplar Creek is a 4th-order stream and the largest watershed that drains Reservation lands. All the waters of the Reservation eventually reach the Clinch River on the southern and western boundaries of the ORR. All available information was collected, synthesized, and evaluated. Field observations were made to support and supplement the available information. Geographic information system mapping techniques were used to develop several quantitative attributes about the study areas. Narrative descriptions of each ANA and ARA and tables of numerical data were prepared. Criteria for assessment and evaluation were developed, and eight categories of factors were devised to produce a ranking system. The evaluation factors used in the ranking system were: (A) size of area, (B) percentage of watershed protected, (C) taxa present with protected status, (D) overall biotic diversity, (E) stream features, (F) water quality and use support ratings, (G) disturbance regime, and (H) other factors. Each factor was evaluated on a 5-point ranking scale (0-4), and each area received a composite score, where 32 was the

Impact of initial spacing on yield per acre and wood quality of unthinned loblolly pine at age 21

Science.gov (United States)

Alexander, III Clark; Richard F. Daniels; Lewis Jordan; Laurie Schimleck

2010-01-01

The market for southern pine first thinnings is soft. Thus, forest managers are planting at wider spacings, and using weed control and fertilization to grow chipping-saw and sawtimber trees in shorter rotations. A 21-year-old unthinned spacing study was sampled to determine the effect of initial spacing on wood quality and yield per acre of planted loblolly pine (

Species-specific spatial characteristics in reserve site selection

NARCIS (Netherlands)

Groeneveld, R.A.

2010-01-01

This paper addresses the problem of selecting reserve sites cost-effectively, taking into account the mobility and habitat area requirements of each species. Many reserve site selection problems are analyzed in mixed-integer linear programming (MILP) models due to the mathematical solvers available

US uranium reserves

International Nuclear Information System (INIS)

Hansen, M.V.

1981-01-01

The current low level of demand, compounded by rapidly rising costs and low prices, has caused a significant reduction in drilling for uranium in the United States, and the trend is likely to continue for a few more years. The effect on uranium reserves will be fewer additions to reserves because less exploration is being done. Further reductions will occur, especially in low-cost reserves, because of increasing costs, continuing depletion through production, and erosion through the high grading of deposits to fulfill previous contractual commitments. During the past several years, it has been necessary to increase the upper reserve cost level twice to compensate for rising costs. Rising costs are reducing the $15 reserves, the cost category corresponding most closely to the present market price, to an insignificant level. An encouraging factor related to US uranium reserves is that the US position internationally, as far as quantity is concerned, is not bad for the longer term. Also, there is a general opinion that US consumers would rather contract for domestic uranium than for foreign because of greater assurance of supply. Still another factor, nearly impossible to assess, is what effect rising costs in other countries will have on their uranium reserves. The annual conferences between the Grand Junction Area Office staff and major uranium companies provide a broad overview of the industry's perception of the future. It is not optimistic for the short term. Many companies are reducing their exploration and mining programs; some are switching to other more marketable mineral commodities, and a few are investing more heavily in foreign ventures. However, there is general optimism for the long term, and many predict a growth in demand in the mid-1980s. If the industry can survive the few lean years ahead, rising prices may restore its viability to former levels

7 CFR 623.13 - Wetlands reserve plan of operations.

Science.gov (United States)

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Wetlands reserve plan of operations. 623.13 Section... CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES EMERGENCY WETLANDS RESERVE PROGRAM § 623.13 Wetlands reserve plan of operations. (a) After NRCS has accepted the applicant for enrollment in the...

Prevalence of and factors associated with overweight among university students from Rio Branco, Acre – Brazil

Directory of Open Access Journals (Sweden)

Gustavo de Souza Moretti

2014-05-01

The aim of this study was to determine the prevalence of and factors associated with overweight among university students from the city of Rio Branco, Acre, Brazil. A cross-sectional study was conducted on 1,104 students (mean age: 24 years from Rio Branco, Acre. Overweight was used as the dependent variable. The following independent variables were studied: socioeconomic variables (gender, age, teaching institution, period of study, marital status, income, household members, living with other people, parent’s education level, and working or not; self-reported health and morbidity variables (health perception, hypertension, diabetes, and altered cholesterol; lifestyle variables (physical activity, watching television, computer use, smoking, and alcohol consumption. The nutritional status was classified based on body mass index. Univariate analysis was performed using Pearson’s chi-squared test or Fisher’s exact test. Variables with a p value < 20% on univariate analysis were included in the multiple Poisson regression model. The prevalence of overweight was 35.6%. In the multiple regression model for male students adjusted for age, overweight was associated with marital status, household income, hypertension, and watching television every day. In the model for female students, the variables that remained associated were self-perceived health status, hypertension, and alcohol consumption in the last month. Overweight is determined by a combination of different factors which differed in the present study between men and women.

Characterization Report for the 92-Acre Area of the Area 5 Radioactive Waste Management Site, Nevada Test Site, Nevada

International Nuclear Information System (INIS)

Bechtel Nevada; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

2006-01-01

The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office manages two low-level Radioactive Waste Management Sites at the Nevada Test Site. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste. This report summarizes characterization and monitoring work pertinent to the 92-Acre Area in the southeast part of the Area 5 Radioactive Waste Management Sites. The decades of characterization and assessment work at the Area 5 RWMS indicate that the access controls, waste operation practices, site design, final cover design, site setting, and arid natural environment contribute to a containment system that meets regulatory requirements and performance objectives for the short- and long-term protection of the environment and public. The available characterization and Performance Assessment information is adequate to support design of the final cover and development of closure plans. No further characterization is warranted to demonstrate regulatory compliance. U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office is proceeding with the development of closure plans for the six closure units of the 92-Acre Area

Characterization Report for the 92-Acre Area of the Area 5 Radioactive Waste Management Site, Nevada Test Site, Nevada

Energy Technology Data Exchange (ETDEWEB)

Bechtel Nevada; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

2006-06-01

The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office manages two low-level Radioactive Waste Management Sites at the Nevada Test Site. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste. This report summarizes characterization and monitoring work pertinent to the 92-Acre Area in the southeast part of the Area 5 Radioactive Waste Management Sites. The decades of characterization and assessment work at the Area 5 RWMS indicate that the access controls, waste operation practices, site design, final cover design, site setting, and arid natural environment contribute to a containment system that meets regulatory requirements and performance objectives for the short- and long-term protection of the environment and public. The available characterization and Performance Assessment information is adequate to support design of the final cover and development of closure plans. No further characterization is warranted to demonstrate regulatory compliance. U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office is proceeding with the development of closure plans for the six closure units of the 92-Acre Area.

40 CFR 80.605 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 80.605 Section 80.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA...

40 CFR 80.609 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 80.609 Section 80.609 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA...

40 CFR 80.534 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 80.534 Section 80.534 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA...

40 CFR 73.25 - Phase I extension reserve.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Phase I extension reserve. 73.25 Section 73.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations § 73.25 Phase I extension reserve. The...

Keratella lenzi (Hauer, 1953: a new occurrence for Acre State, Brazil, specifically in Igarapé Jesumira located in Parque Nacional da Serra do Divisor

Directory of Open Access Journals (Sweden)

Erlei Cassiano Keppeler

2010-04-01

Full Text Available http://dx.doi.org/10.5007/2175-7925.2010v23n2p219 Keratella lenzi (Hauer, 1953: uma nova ocorrência no estado do Acre, Brasil, especificamente no Igarapé Jesumira localizado no Parque Nacional da Serra do Divisor. Rotíferos são importantes componentes do plâncton de águas continentais e, ocupam o nicho ecológico de pequenos filtradores. A ampla distribuição deste grupo em planícies de inundação deve-se ao fato de sua tolerância às mudanças ambientais, causadas especialmente pelas águas altas e, por conseguinte diversificação dos nichos. Todavia, a biodiversidade destes ambientes ainda é desconhecida, especialmente no Noroeste do Estado do Acre. Os organismos foram coletados usando rede de plâncton com malha de abertura de 50μm e, conservados em solução de formol a concentração de 4%. Este trabalho registrou a primeira ocorrência de Keratella lenzi no Estado do Acre, identificada nas amostras de plâncton do Igarapé Jesumira (7º28’10,2”S e 73º33’54,6”.

Serpentes peçonhentas e ofidismo em Cruzeiro do Sul, Alto Juruá, Estado do Acre, Brasil Venomous snakes and ophidism in Cruzeiro do Sul, Alto Juruá, State of Acre, Brazil

Directory of Open Access Journals (Sweden)

Paulo Sérgio Bernarde

2012-03-01

Full Text Available Apesar da importância dos acidentes ofídicos na Saúde Pública, são relativamente poucas as pesquisas realizadas sobre esse tema no Brasil. Devido aos poucos estudos sobre ofidismo na Amazônia e especialmente no estado do Acre, trabalhos epidemiológicos são de grande relevância. Esse estudo apresenta a lista de serpentes peçonhentas e aspectos epidemiológicos dos acidentes ofídicos em Cruzeiro do Sul, região do Alto Juruá (Acre, verificando quais gêneros de serpentes são responsáveis pelos envenenamentos e aspectos que envolvem o acidente e o atendimento hospitalar. Os dados epidemiológicos foram coligidos a partir do SINAN (Sistema de Informações de Agravos de Notificação, no setor de vigilância epidemiológica do Hospital Regional do Juruá, no município de Cruzeiro do Sul. Sete espécies de serpentes peçonhentas foram registradas nesse município: três viperídeos (Bothrops atrox, Bothriopsis bilineata e Lachesis muta e quatro elapídeos (Micrurus hemprichii, M. lemniscatus, M. remotus and M. surinamensis. Durante o período de dois anos (agosto de 2007 a julho de 2009 foram registrados 195 casos de acidentes ofídicos. Cinquenta e um por cento dos acidentes foi classificado como laquético (Lachesis, seguido pelo botrópico (Bothrops e Bothriopsis com 38% e crotálico (Crotalus com 2%. Em 9% dos casos o gênero da serpente envolvida não foi informado. A maioria dos acidentes envolveu indivíduos adultos do gênero masculino em área rural, afetados principalmente nos membros inferiores. Os casos ocorreram mais frequentemente nos meses de novembro a abril, coincidindo com os maiores níveis pluviométricos. A maioria dos acidentes foi atribuída equivocadamente à serpente L. muta, tendo sido provavelmente causados por B. atrox.Despite the importance of accidents involving snakebites, research on this theme in Brazil is relatively rare, especially in the Amazon region. Due to the poor number of studies about ophidism

Demand as Frequency Controlled Reserve

DEFF Research Database (Denmark)

Xu, Zhao; Togeby, Mikael; Østergaard, Jacob

This report summaries the research outcomes of the project ‘Demand as Frequency Controlled Reserve (DFR)’, which has received the support from Energinet.dk’s PSO program, Grant no. 2005-2-6380. The objective of this project is to investigate the technology of using electricity demands for providing...

Taxonomia de solos desenvolvidos sobre depósitos sedimentares da Formação Solimões no Estado do Acre Taxonomy of soils developed under sedimentary deposits from Solimões Formation in Acre state, Brazil

Directory of Open Access Journals (Sweden)

Thiago de Andrade Bernini

2013-01-01

Full Text Available Os solos do Estado do Acre na maioria são formados sobre material de origem com grande influência da orogênese Andina, com elevados teores de Ca2+, Mg2+ e Al3+ concomitantemente, associado às combinações diferenciadas dos valores da CTC, V e m. O objetivo deste trabalho foi caracterizar e classificar os solos de uma topossequência sobre material sedimentar da Formação Solimões, no município de Feijó, Acre. Foram abertas trincheiras em três pontos de uma topossequência: terço superior (P1, terço médio (P2 e terço inferior (P3. Os solos foram analisados quanto a morfologia, granulometria (areia, silte e argila, complexo sortivo (Ca2+, Mg2+, Na+, K+ e Al3+, acidez potencial (H+Al, P assimilável, pH (água e KCl, superfície específica, ataque sulfúrico (óxidos de Fe, Al, Ti e Si, mineralogia (frações areia, silte e argila. Os solos foram classificados segundo o Sistema Brasileiro de Classificação de Solos (SiBCS, 2006 e apresentada uma proposta de classificação considerando as peculiaridades do solos da região. Os solos têm baixo grau de desenvolvimento pedogenético, com minerais da fração argila de alta atividade, além da presença de minerais primários, como feldspatos e plagioclásios, nas frações areia e silte. Os solos foram classificados segundo o SiBCS atual como Argissolo Vermelho Álitico plíntico (P1, Argissolo Acinzentado Distrófico plíntico (P2 e Cambissolo Háplico Ta Eutrófico típico (P3.The soils from the State of Acre (Brazil are mostly formed under parent material with influence of Andean orogeny, showing high Ca2+, Mg2+and Al3+ contents concomitantly associated with different combinations of CEC, V and m values. This study aimed to characterize and classify soils of a topossequence under sedimentary material from Solimões Formation, in the county of Feijó, State of Acre, Brazil. Trenches were opened in three points on a topossequence: shoulder (P1, backslope (P2 and footslope (P3. The

75 FR 49513 - Final Environmental Impact Statement for the Ione Band of Miwok Indians 228.04-Acre Fee-to-Trust...

Science.gov (United States)

2010-08-13

... construct a casino, hotel, parking areas and other facilities. The proposed project is located partially... square-foot hotel and a 30,000 square- foot event/conference center on the 228.04-acre site. The gaming... restaurant, bar, and coffee bar), meeting space, guest support services, offices, and security area. The five...

The concept of incomplete fibromyalgia syndrome: comparison of incomplete fibromyalgia syndrome with fibromyalgia syndrome by 1990 ACR classification criteria and its implications for newer criteria and clinical practice.

Science.gov (United States)

Yunus, Muhammad B; Aldag, Jean C

2012-03-01

The 1990 American College of Rheumatology (ACR) classification criteria for fibromyalgia/fibromyalgia syndrome (FMS) has 2 components: (a) widespread pain (WSP) and (b) presence of 11 or more tender points (TP) among possible 18 sites. Some clinic patients fulfill 1 component but not the other. We have considered these patients to have incomplete FMS (IFMS). The purpose of this study was to examine the clinical and psychological differences between IFMS and FMS (by 1990 ACR criteria) because such comparison may be helpful to diagnose patients in the clinic. Six hundred consecutive patients referred to our rheumatology clinic with a diagnosis of FMS were examined by a standard protocol to determine whether they fulfilled the 1990 criteria for FMS. Both IFMS and FMS groups were compared in demographic, clinical, and psychological variables using appropriate statistical methods. One hundred twelve (18.7%) patients did not satisfy the 1990 ACR criteria and were classified as IFMS. Symptoms in IFMS and FMS were similar, generally with less frequent and less severe symptoms in the IFMS group. In IFMS, no significant difference was found among the WSP and TP component subgroups. Both TP and WSP were correlated with important features of FMS. Fulfillment of the ACR 1990 criteria is not necessary for a diagnosis of FMS in the clinic. For diagnosis and management of FMS in the clinical setting, IFMS patients, along with consideration of the total clinical picture, may be considered to have FMS, albeit generally mild.

Impacto da Educação na Renda das Famílias Rurais da Amazônia: Uma Análise a Partir da Agricultura Familiar no Acre.

Directory of Open Access Journals (Sweden)

Francisco Dietima da Silva Bezerra

2014-10-01

Full Text Available No Brasil, tem se observado nas últimas décadas, a persistência de um quadro histórico de alta desigualdade de renda que têm contribuindo para que o país seja considerado como uma das nações mais desiguais do planeta. Dentre os fatores que têm contribuído para manter as disparidades de rendimentos em patamares tão elevados, destaca-se a heterogeneidade educacional, principalmente no meio rural. Diante da importância do tema tratado, a presente pesquisa consiste em analisar o impacto da educação no desempenho econômico das famílias rurais do Estado do Acre. Utiliza-se a metodologia do projeto de pesquisa Análise Socioeconômica dos Sistemas de Produção Familiar no Estado do Acre (ASPF, desenvolvido pelo Centro de Ciências Jurídicas e Sociais Aplicadas (CCJSA da Universidade Federal do Acre (UFAC, a partir de indicadores de resultado econômico e medidas de relação. Os resultados indicam que no Vale do Acre o nível de escolaridade influencia significativamente no desempenho econômico das famílias analisadas, diferentemente do Vale do Juruá, em que o desempenho econômico tem menor relação com a escolaridade das famílias e é mais fortemente condicionado por outros fatores estruturais e/ou de mercado.

PROFIT-PC: a program for estimating maximum net revenue from multiproduct harvests in Appalachian hardwoods

Science.gov (United States)

Chris B. LeDoux; John E. Baumgras; R. Bryan Selbe

1989-01-01

PROFIT-PC is a menu driven, interactive PC (personal computer) program that estimates optimum product mix and maximum net harvesting revenue based on projected product yields and stump-to-mill timber harvesting costs. Required inputs include the number of trees/acre by species and 2 inches diameter at breast-height class, delivered product prices by species and product...

Office of Technology Development Program for Research, Development, Demonstration, Testing, and Evaluation

International Nuclear Information System (INIS)

1993-10-01

DOE has set a goal to clean up its complex and to bring all sites into compliance with applicable environmental regulations. This initiative is slated for completion by the year 2019. Four years ago there was no coordinated plan for identifying or cleaning these contaminated sites. Since 1989, DOE's Office of Environmental Restoration and Waste Management has invested time, money, and manpower to establish a wide range of programs to meet this immense challenge. DOE is responsible for waste management and clean up of more than 100 contaminated installations in 36 states and territories. This includes 3,700 sites: over 26,000 acres, with hazardous or radioactive contaminated surface or groundwater, soil, or structures; over 26,000 acres requiring remediation, with the number growing as new sites are defined; 500 surplus facilities awaiting decontamination and decommissioning and approximately 5,000 peripheral properties (residences, businesses) that have soil contaminated with uranium tailings

WTO Compliance Status of the Conservation Security Program (CSP) and the Conservation Reserve Program (CRP)

National Research Council Canada - National Science Library

Schnepf, Randy

2007-01-01

.... This report is not a legal opinion, but describes both the CSP and CRP programs, the WTO Annex II provisions that govern compliance, and the potential issues involved in evaluating the compliance status of the two programs. This report will be updated as events warrant.

Optimal Bidding Strategy of Generation Companies (GenCos in Energy and Spinning Reserve Markets Using Linear Programming

Directory of Open Access Journals (Sweden)

Hassan Barati

2011-10-01

Full Text Available In this paper a new bidding strategy become modeling to day-ahead markets. The proposed algorithm is related to the point of view of a generation company (Genco that its end is maximized its benefit as a participant in sale markets of active power and spinning reserve. In this method, hourly forecasted energy price (FEP and forecasted reserve price (FRP is used as a reference to model the possible and probable price strategies of Gencos. A bi-level optimization problem That first level, is used to maximize the individual Genco’s payoffs for obtaining the optimal offered quantity of Gencos. The second one, uses the results of the upper sub-problem and minimizes the consumer’s payment with regard to the technical and network constraints, which leads to the awarded generation of the Gencos. In this paper use of the game theory in exist optimization model. The paper proposes a linear programming approach. A six bus system is employed to illustrate the application of the proposed method and to show its high precision and capabilities.

Oak Ridge Reservation Federal Facility Agreement quarterly report for the Environmental Restoration Program, Volume 1, October--December 1992

International Nuclear Information System (INIS)

1993-01-01

This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program which are specified in the Oak Ridge Reservation (ORR) Federal Facility Agreement (FFA) established between the US Department of Energy (DOE), the US Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered is October through December 1992(first quarter of FY 1993). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been formally approved as FY 1993 commitments. This first section is followed by: significant accomplishments; technical status at Y-12 operable units, Oak Ridge National Laboratory, Oak Ridge K-25 site, Clinch River, Oak Ridge Associated Universities, and technical oversight and technical programs; and response action contractor assignments

Reserve selection with land market feedbacks.

Science.gov (United States)

Butsic, Van; Lewis, David J; Radeloff, Volker C

2013-01-15

How to best site reserves is a leading question for conservation biologists. Recently, reserve selection has emphasized efficient conservation: maximizing conservation goals given the reality of limited conservation budgets, and this work indicates that land market can potentially undermine the conservation benefits of reserves by increasing property values and development probabilities near reserves. Here we propose a reserve selection methodology which optimizes conservation given both a budget constraint and land market feedbacks by using a combination of econometric models along with stochastic dynamic programming. We show that amenity based feedbacks can be accounted for in optimal reserve selection by choosing property price and land development models which exogenously estimate the effects of reserve establishment. In our empirical example, we use previously estimated models of land development and property prices to select parcels to maximize coarse woody debris along 16 lakes in Vilas County, WI, USA. Using each lake as an independent experiment, we find that including land market feedbacks in the reserve selection algorithm has only small effects on conservation efficacy. Likewise, we find that in our setting heuristic (minloss and maxgain) algorithms perform nearly as well as the optimal selection strategy. We emphasize that land market feedbacks can be included in optimal reserve selection; the extent to which this improves reserve placement will likely vary across landscapes. Copyright © 2012 Elsevier Ltd. All rights reserved.

Walla Walla River Basin Fish Habitat Enhancement Project, 2002-2003 Annual Report.

Energy Technology Data Exchange (ETDEWEB)

Volkman, Jed (Confederated Tribes of the Umatilla Indian Reservation, Pendleton, OR)

2005-12-01

In 2002 and 2003, the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) Fisheries Habitat Program implemented stream habitat restoration and protection efforts on private properties in the Walla Walla River Basin with funding from Bonneville Power Administration (BPA). The objective of this effort is to protect and restore habitat critical to the recovery of weak or reintroduced populations of salmonid fish. The CTUIR has currently enrolled nine properties into this program: two on Couse Creek, two adjacent properties on Blue Creek, one on Patit Creek, and four properties on the mainstem Walla Walla River. Major accomplishments during the reporting period include the following: (1) Secured approximately $229,000 in project cost share; (2) Purchase of 46 acres on the mainstem Walla Walla River to be protected perpetually for native fish and wildlife; (3) Developed three new 15 year conservation easements with private landowners; (4) Installed 3000 feet of weed barrier tarp with new plantings within project area on the mainstem Walla Walla River; (5) Expanded easement area on Couse Creek to include an additional 0.5 miles of stream corridor and 32 acres of upland habitat; (6) Restored 12 acres on the mainstem Walla Walla River and 32 acres on Couse Creek to native perennial grasses; and (7) Installed 50,000+ new native plants/cuttings within project areas.

US crude oil, natural gas, and natural gas liquids reserves: 1990 annual report

International Nuclear Information System (INIS)

1991-09-01

The primary focus of this report is to provide an accurate estimate of US proved reserves of crude oil, natural gas, and natural gas liquids. These estimates were considered essential to the development, implementation, and evaluation of natural energy policy and legislation. In the past, the government and the public relied upon industry estimates of proved reserves. These estimates were prepared jointly by the American Petroleum Institute (API) and the American Gas Association (AGA) and published in their annual report, Reserves of Crude Oil, Natural Gas Liquids, and Natural Gas in the United States and Canada. However, API and AGA ceased publication of reserves estimates after their 1979 report. By the mid-1970's, various federal agencies had separately established programs to collect data on, verify, or independently estimate domestic proved reserves of crude oil or natural gas. Each program was narrowly defined to meet the particular needs of the sponsoring agency. In response to recognized need for unified, comprehensive proved reserves estimates, Congress in 1977 required the Department of Energy to prepare such estimates. To meet this requirement, the EIA's reserves program was undertaken to establish a unified, verifiable, comprehensive, and continuing statistical series for proved reserves of crude oil and natural gas. The program was expanded to include proved reserves of natural gas liquids in the 1979 report. 36 refs., 11 figs., 16 tabs

Cernavoda NPP Unit 1: Operating experience program and plant specific performance indicators (level 2)

International Nuclear Information System (INIS)

Teodor, Vasile; Popa, Viorel

1998-01-01

The basis for the Operating Experience Program was set in place since early stages of the commissioning phase (1993), when a system based on the Canadian approach was implemented for reporting, reviewing, assessing and establishing of the necessary corrective action for unplanned events. This system provided excellent opportunity to train staff in unplanned event assessment methodology, and prepare the station for the formal reporting process following criticality in accordance with the licensing requirements. The formal process, set in place after criticality is described in Station Instruction Procedure SI-01365-P13 'Unplanned Event Report' and was developed under the supervision of Safety and Compliance Department. In parallel, a program for information exchange and trending of performance indicators was developed by Technical Services Department. The WANO recommendations following August 1997 Peer Review provided the opportunity for a better understanding and reconsideration of the Operating Experience Program. As a result, all the activities related to this topic were assigned to a new structure, within Safety and Compliance Department. As such an Operating Experience Group was created and a new program is now being developed in an integrated and centralized manner. The content of the paper is the following: - Overview; - Operating Experience Program; - Event Analysis (Unplanned Events Assessment System - UEIR Process- and Systematic Analysis of Operational Events - ACR Process); - Information Exchange Program; - Monitoring of Operating Experience - Plant Specific Performance Indicators; - Purpose; - Level 2 Performance Indicators. Four appendices are added containing: - A. Station performance indicators/targets (Level 2); - B. SPI (Station Performance Indicators - Level 2) - Graphics; - C. UEIR, LRS (Safety and Licensing Review Sheet), UEFR (Unplanned Event Follow-up Report), ACR and OPEX forms. (authors)

32 CFR 199.24 - TRICARE Reserve Select.

Science.gov (United States)

2010-07-01

...) MISCELLANEOUS CIVILIAN HEALTH AND MEDICAL PROGRAM OF THE UNIFORMED SERVICES (CHAMPUS) § 199.24 TRICARE Reserve... rules and procedures as may be appropriate to the area involved. (4) Terminology. Certain terminology is...

Heterotrophic components of soil respiration in pastures and forests in southwestern Amazonia, Acre, Brazil

Directory of Open Access Journals (Sweden)

Eric Atlas Davidson

2008-12-01

Full Text Available In this paper we present data on soil microbial biomass and heterotrophic respiration in pastures, mature and secondary forests, in order to elucidate their contribution to total CO2 flux from soil to atmosphere. The research was conducted in Southwestern Amazonia, Acre State, Brazil. Microbial biomass was estimated using a variation of the traditional fumigation-extraction method and heterotrophic respiration was measured using respirometry flasks attached to an infrared gas analyzer. Soil microbial biomass and heterotrophic respiration did not differ statistically among pastures, mature and secondary forests. These laboratory results indicate that higher CO2 fluxes from pasture soils measured in situ are probably due to higher root respiration by pasture grasses.

An Analysis of Profitability Factors for Selected Farming Types in the Minnesota Vocational Agriculture Farm Management Education Program.

Science.gov (United States)

Kleene, Marvin

1980-01-01

A study was conducted to determine the impact profitability factors have on farm labor earnings for farms enrolled in the Minnesota Vocational Agriculture Farm Management Education Program. The most important predictors of labor earnings were size of business, gross return per cropped acre, and index return per $100 of feed fed. (LRA)

Detection of the pandemic norovirus variant GII.4 Sydney 2012 in Rio Branco, state of Acre, northern Brazil

Directory of Open Access Journals (Sweden)

Luciana Damascena da Silva

2013-12-01

Full Text Available Noroviruses (NoVs are important cause of gastroenteritis in humans worldwide. Genotype GII.4 is responsible for the majority of outbreaks reported to date. This study describes, for the first time in Brazil, the circulation of NoV GII.4 variant Sydney 2012 in faecal samples collected from children aged less than or equal to eight years in Rio Branco, state of Acre, northern Brazil, during July-September 2012.

Association of wintering raptors with Conservation Reserve Enhancement Program grasslands in Pennsylvania

Science.gov (United States)

Wilson, A.; Brittingham, M.; Grove, G.

2010-01-01

Conservation grasslands can provide valuable habitat resource for breeding songbirds, but their value for wintering raptors has received little attention. We hypothesized that increased availability of grassland habitat through the Conservation Reserve Enhancement Program (CREP) has resulted in an increase or redistribution in numbers of four species of raptors in Pennsylvania since 2001. We tested this by analyzing winter raptor counts from volunteer surveys, conducted from 2001 to 2008, for Red-tailed Hawks (Buteo jamaicensis), Rough-legged Hawks (Buteo lagopus), Northern Harriers (Circus cyaneus), and American Kestrels (Falco sparverius). During that period, numbers of wintering Northern Harriers increased by more than 20% per year. Log-linear Poisson regression models show that all four species increased in the region of Pennsylvania that had the most and longest-established conservation grasslands. At the county scale (N= 67), Bayesian spatial models showed that spatial and temporal population trends of all four species were positively correlated with the amount of conservation grassland. This relationship was particularly strong for Northern Harriers, with numbers predicted to increase by 35.7% per year for each additional 1% of farmland enrolled in CREP. Our results suggest that conservation grasslands are likely the primary cause of the increase in numbers of wintering Northern Harriers in Pennsylvania since 2001. ?? 2010 The Authors. Journal of Field Ornithology ?? 2010 Association of Field Ornithologists.

41 CFR 101-26.504 - [Reserved

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true [Reserved] 101-26.504 Section 101-26.504 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.5-GSA...

41 CFR 101-26.601 - [Reserved

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true [Reserved] 101-26.601 Section 101-26.601 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.6...

Energetic particles beyond the heliospheric shock: Anomalous Cosmic Rays (ACRs), Pick-Up Ions (PUIs) and the associated energetic neutral atoms (ENAs)

International Nuclear Information System (INIS)

Fichtner, Horst; Czechowski, Andrzej; Fahr, Hans J.; Lay, Guenter

2000-01-01

The Voyager 1 spacecraft is expected to encounter the heliospheric termination shock within the next decade. Besides the ongoing discussion how to possibly predict the time of this encounter, there is a growing interest into a more detailed description of the region beyond the heliospheric shock, i.e., the heliosheath. Refinements of the so far rather crude models will facilitate interpretation of forthcoming data. We report on results obtained with our model of the transport of ACRs in the heliosheath. In improvement of earlier approaches it is based on a solar wind background flow computed with a self-consistent large-scale model of the heliosphere. Besides these downstream ACR spectra, which will become accessible for in situ observation as soon as the Voyager spacecraft will have crossed the heliospheric shock, we study the potential of observations of the flux of ENAs to remotely explore the structure of the heliosheath. In particular, as part of a comparison of the various ENA sources, we will address the significance of the contribution of those ENAs resulting from a de-charging of PUIs

Ambiente, saúde e trabalho: temas geradores para ensino em saúde e segurança do trabalho no Acre, Brasil

Directory of Open Access Journals (Sweden)

Josina Maria Pontes Ribeiro

Full Text Available O artigo apresenta ambiente, saúde e trabalho como temas geradores necessários à construção de uma tecnologia social para educação profissional, considerando a ergologia como perspectiva de análise, e, o diálogo, como estratégia de ensino em Saúde e Segurança no Trabalho para Agentes de Combate a Endemias em Rio Branco, Acre, Brasil. A definição dos temas geradores é resultado do diálogo entre pesquisadores de diferentes áreas, trabalhadores que atuam ou atuaram no combate às endemias, bem como de discentes e docentes do Curso Técnico em Segurança do Trabalho no Instituto Federal do Acre (IFAC, mediante exercício de atividades de ensino, pesquisa e extensão. As pesquisas histórica e documental permitiram que se estabelecessem os nexos entre os projetos de desenvolvimento que impactaram significativamente o ambiente e as relações de trabalho na saúde daí resultantes.

Joint energy and spinning reserve dispatching and pricing

International Nuclear Information System (INIS)

Rashidinejad, M.; Song, Y.-H.; Javidi Dasht-Bayaz, M.H.

2000-01-01

Unpredictable load demand variations, and also sudden generation interruption, may cause imbalance in power systems. To prevent any blackout and to reduce such total power imbalance, spinning reserve can provide electric power system ability to respond. Adequate amount of spinning reserve should be based on economy and risk as an optimal decision making. This paper uses Quadratic Programming (QP) method to solve Joint Energy and Spinning Reserve Dispatch (JESRD) problem and derives the optimal price of spinning reserve. In JESRD, Unserved Energy Cost (UEC) is considered as an Opportunity Cost of Spinning Reserve (OCSR). To distribute the System Reserve Requirements (SRR) among generation units, two different models, Fixed Reserve Percentage (FRP) or fixed allocation model and Non-Fixed Reserve Percentage (NFRP) or flexible allocation model has been investigated. Numerical results on a 5-bus test system and the 30-bus IEEE standard system, considering FRP and NFRP models are included. (author)

40 CFR 86.220-94 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.220-94 Section 86.220-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

40 CFR 86.217-94 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.217-94 Section 86.217-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

40 CFR 86.212-94 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.212-94 Section 86.212-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

40 CFR 86.241-94 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.241-94 Section 86.241-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

40 CFR 86.207-94 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.207-94 Section 86.207-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

40 CFR 86.243-94 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.243-94 Section 86.243-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

40 CFR 86.210-94 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.210-94 Section 86.210-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

40 CFR 86.245-94 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.245-94 Section 86.245-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

40 CFR 86.225-94 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] 86.225-94 Section 86.225-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger...

SU-E-I-81: Assessment of CT Radiation Dose and Image Quality for An Automated Tube Potential Selection Algorithm Using Adult Anthropomorphic and ACR Phantoms

International Nuclear Information System (INIS)

Mahmood, U; Erdi, Y; Wang, W

2014-01-01

Purpose: To assess the impact of General Electrics (GE) automated tube potential algorithm, kV assist (kVa) on radiation dose and image quality, with an emphasis on optimizing protocols based on noise texture. Methods: Radiation dose was assessed by inserting optically stimulated luminescence dosimeters (OSLs) throughout the body of an adult anthropomorphic phantom (CIRS). The baseline protocol was: 120 kVp, Auto mA (180 to 380 mA), noise index (NI) = 14, adaptive iterative statistical reconstruction (ASiR) of 20%, 0.8s rotation time. Image quality was evaluated by calculating the contrast to noise ratio (CNR) and noise power spectrum (NPS) from the ACR CT accreditation phantom. CNRs were calculated according to the steps described in ACR CT phantom testing document. NPS was determined by taking the 3D FFT of the uniformity section of the ACR phantom. NPS and CNR were evaluated with and without kVa and for all available adaptive iterative statistical reconstruction (ASiR) settings, ranging from 0 to 100%. Each NPS was also evaluated for its peak frequency difference (PFD) with respect to the baseline protocol. Results: The CNR for the adult male was found to decrease from CNR = 0.912 ± 0.045 for the baseline protocol without kVa to a CNR = 0.756 ± 0.049 with kVa activated. When compared against the baseline protocol, the PFD at ASiR of 40% yielded a decrease in noise magnitude as realized by the increase in CNR = 0.903 ± 0.023. The difference in the central liver dose with and without kVa was found to be 0.07%. Conclusion: Dose reduction was insignificant in the adult phantom. As determined by NPS analysis, ASiR of 40% produced images with similar noise texture to the baseline protocol. However, the CNR at ASiR of 40% with kVa fails to meet the current ACR CNR passing requirement of 1.0

SU-E-I-81: Assessment of CT Radiation Dose and Image Quality for An Automated Tube Potential Selection Algorithm Using Adult Anthropomorphic and ACR Phantoms

Energy Technology Data Exchange (ETDEWEB)

Mahmood, U; Erdi, Y; Wang, W [Memorial Sloan Kettering Cancer Center, NY, NY (United States)

2014-06-01

Purpose: To assess the impact of General Electrics (GE) automated tube potential algorithm, kV assist (kVa) on radiation dose and image quality, with an emphasis on optimizing protocols based on noise texture. Methods: Radiation dose was assessed by inserting optically stimulated luminescence dosimeters (OSLs) throughout the body of an adult anthropomorphic phantom (CIRS). The baseline protocol was: 120 kVp, Auto mA (180 to 380 mA), noise index (NI) = 14, adaptive iterative statistical reconstruction (ASiR) of 20%, 0.8s rotation time. Image quality was evaluated by calculating the contrast to noise ratio (CNR) and noise power spectrum (NPS) from the ACR CT accreditation phantom. CNRs were calculated according to the steps described in ACR CT phantom testing document. NPS was determined by taking the 3D FFT of the uniformity section of the ACR phantom. NPS and CNR were evaluated with and without kVa and for all available adaptive iterative statistical reconstruction (ASiR) settings, ranging from 0 to 100%. Each NPS was also evaluated for its peak frequency difference (PFD) with respect to the baseline protocol. Results: The CNR for the adult male was found to decrease from CNR = 0.912 ± 0.045 for the baseline protocol without kVa to a CNR = 0.756 ± 0.049 with kVa activated. When compared against the baseline protocol, the PFD at ASiR of 40% yielded a decrease in noise magnitude as realized by the increase in CNR = 0.903 ± 0.023. The difference in the central liver dose with and without kVa was found to be 0.07%. Conclusion: Dose reduction was insignificant in the adult phantom. As determined by NPS analysis, ASiR of 40% produced images with similar noise texture to the baseline protocol. However, the CNR at ASiR of 40% with kVa fails to meet the current ACR CNR passing requirement of 1.0.

25 CFR 23.32 - Purpose of off-reservation grants.

Science.gov (United States)

2010-04-01

... Indian foster and adoptive children with the goal of strengthening and stabilizing Indian families; (c... Grants to Off-Reservation Indian Organizations for Title II Indian Child and Family Service Programs § 23... family service programs for the purpose of stabilizing Indian families and tribes, preventing the breakup...

COGNITIVE RESERVE IN DEMENTIA: IMPLICATIONS FOR COGNITIVE TRAINING

Directory of Open Access Journals (Sweden)

Sara eMondini

2016-04-01

Full Text Available Cognitive reserve (CR is a potential mechanism to cope with brain damage. The aim of this study was to evaluate the effect of cognitive reserve on a cognitive training (CT in a group of patients with dementia. 86 participants with mild to moderate dementia were identified by their level of CR quantified by the Cognitive Reserve Index questionnaire (CRIq and underwent a cycle of CT. A global measure of cognition (MMSE was obtained before (T0 and after (T1 the training. Multiple linear regression analyses highlighted CR as a significant factor able to predict changes in cognitive performance after the CT. In particular, patients with lower CR benefited from a CT program more than those with high CR. These data show that CR can modulate the outcome of a CT program and that it should be considered as a predictive factor of neuropsychological rehabilitation training efficacy in people with dementia.

Utilización del acrílico dental (metil metacrilato) como barra estabilizadora-conectora para reducciones cerradas en fracturas de tibia/peroné o radio/cúbito en caninos

OpenAIRE

Cavero A., Francisco; Fernández A., Víctor

2005-01-01

El metil metacrilato (mmc) es una resina acrílica utilizada en moldes para fabricar prótesis dentales y puede cumplir la función de barra estabilizadora-conectora en la reducción de fracturas, permitiendo la colocación de clavos en planos múltiples. El presente trabajo tuvo como objetivo comprobar que el acrílico dental sirve como barra conectora en la fijación externa esquelética, y demostrar que es posible fijar las fracturas con un método poco traumático, alejado del foco fracturario, para...

The prognostic value of the clinical ACR classification criteria of knee osteoarthritis for persisting knee complaints and increase of disability in general practice

NARCIS (Netherlands)

Belo, J. N.; Berger, M. Y.; Koes, B. W.; Bierma-Zeinstra, S. M. A.

2009-01-01

Objective: To assess the prognostic value of the clinical American College of Rheumatism (ACR) classification criteria of knee osteoarthritis (OA) on persisting knee complaints and increase of disability in adult patients with knee pain in general practice after 1-year follow-up. Methods: Patients

Application of a Mathematical Model to an Advertisement Reservation Problem

Directory of Open Access Journals (Sweden)

Ozlem COSGUN

2013-01-01

Full Text Available Television networks provide TV programs free of charge to the public. However, they acquire their revenue by telecasting advertisements in the midst of continuing programs or shows. A key problem faced by the TV networks in Turkey is how to accept and televise the advertisements reserved by a client on a specified advertisement break which we called “Advertisement Reservation Problem” (ARP. The problem is complicated by limited time inventory, by different rating points for different target groups, competition avoidance and the relationship between TV networks and clients. In this study we have developed a mathematical model for advertisement reservation problem and extended this model for some cases encountered in real business life. We have also discussed how these cases affect the decisions of a TV network. Mixed integer linear programming approach is proposed to solve these problems. This approach has been implemented to a case taken from one of the biggest TV networks of Turkey.

Water quality, meteorological, and nutrient data collected by the the National Estuarine Research Reserve System's System-wide Monitoring Program (NERRS SWMP), 1994 - 2005 (NODC Accession 0019215)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The National Estuarine Research Reserve System's System-wide Monitoring Program (NERRS SWMP) collected water quality, meteorological, and nutrient data in 25...

Effectiveness of China's National Forest Protection Program and nature reserves.

Science.gov (United States)

Ren, Guopeng; Young, Stephen S; Wang, Lin; Wang, Wei; Long, Yongcheng; Wu, Ruidong; Li, Junsheng; Zhu, Jianguo; Yu, Douglas W

2015-10-01

There is profound interest in knowing the degree to which China's institutions are capable of protecting its natural forests and biodiversity in the face of economic and political change. China's 2 most important forest-protection policies are its National Forest Protection Program (NFPP) and its national-level nature reserves (NNRs). The NFPP was implemented in 2000 in response to deforestation-caused flooding. We undertook the first national, quantitative assessment of the NFPP and NNRs to examine whether the NFPP achieved its deforestation-reduction target and whether the NNRs deter deforestation altogether. We used MODIS data to estimate forest cover and loss across mainland China (2000-2010). We also assembled the first-ever polygon dataset for China's forested NNRs (n = 237, 74,030 km(2) in 2000) and used both conventional and covariate-matching approaches to compare deforestation rates inside and outside NNRs (2000-2010). In 2000, 1.765 million km(2) or 18.7% of mainland China was forested (12.3% with canopy cover of ≥70%)) or woodland (6.4% with canopy cover <70% and tree plus shrub cover ≥40%). By 2010, 480,203 km(2) of forest and woodland had been lost, an annual deforestation rate of 2.7%. Forest-only loss was 127,473 km(2) (1.05% annually). In the NFPP provinces, the forest-only loss rate was 0.62%, which was 3.3 times lower than in the non-NFPP provinces. Moreover, the Landsat data suggest that these loss rates are overestimates due to large MODIS pixel size. Thus, China appears to have achieved, and even exceeded, its target of reducing deforestation to 1.1% annually in the NFPP provinces. About two-thirds of China's NNRs were effective in protecting forest cover (prevented loss 4073 km(2) unmatched approach; 3148 km(2) matched approach), and within-NNR deforestation rates were higher in provinces with higher overall deforestation. Our results indicate that China's existing institutions can protect domestic forest cover. © 2015 The Authors

25 CFR 170.120 - What restrictions apply to the use of an Indian Reservation Road?

Science.gov (United States)

2010-04-01

... Reservation Road? 170.120 Section 170.120 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Use of Irr and Cultural Access Roads § 170.120 What restrictions apply to the use of an Indian...

ACR Appropriateness Criteria on Induction and Adjuvant Therapy for Stage N2 Non-Small-Cell Lung Cancer: Expert Panel on Radiation Oncology-Lung

International Nuclear Information System (INIS)

Gopal, Ramesh S.; Dubey, Sarita; Rosenzweig, Kenneth E.; Chang, Joe Yujiao; Decker, Roy; Gewanter, Richard M.; Kong Fengming; Lally, Brian E.; Langer, Corey J.; Lee, Hoon Ku; Movsas, Benjamin M.D.

2010-01-01

'The American College of Radiology seeks and encourages collaboration with other organizations on the development of the ACR Appropriateness Criteria through society representation on expert panels. Participation by representatives from collaborating societies on the expert panel does not necessarily imply society endorsement of the final document.'

Assessing U.S. coal resources and reserves

Science.gov (United States)

Shaffer, Brian N.

2017-09-27

The U.S. Coal Resources and Reserves Assessment Project, as part of the U.S. Geological Survey (USGS) Energy Resources Program, conducts systematic, geology-based, regional assessments of significant coal beds in major coal basins in the United States. These assessments detail the quantity, quality, location, and economic potential of the Nation’s remaining coal resources and reserves and provide objective scientific information that assists in the formulation of energy strategies, environmental policies, land-use management practices, and economic projections.

Taxation of unmined minerals

International Nuclear Information System (INIS)

Bremberg, B.P.

1989-01-01

This paper reports on the Kentucky Revenue Cabinet which began implementing its controversial unmined minerals tax program. The Revenue Cabinet should complete its first annual assessment under this program in December, 1989. The Revenue Cabinet's initial efforts to collect basic data concerning the Commonwealth's coal bearing lands has yielded data coverage for 5 million of Kentucky's 10 million acres of coal lands. Approximately 1000 detailed information returns have been filed. The returns will be used to help create an undeveloped mineral reserves inventory, determine mineral ownership, and value mineral reserves. This new program is run by the Revenue Cabinet's Mineral Valuation Section, under the Division of Technical Support, Department of Property Taxation. It has been in business since September of 1988

Incentives for Improving Undergraduate Teaching in the California Community Colleges. A Report to the Chancellor's Office on Assembly Concurrent Resolution (ACR) 39, Hayden.

Science.gov (United States)

McHargue, Michael

This report details the response of the Board of Governors of the California Community Colleges to Assembly Concurrent Resolution (ACR) Number 39 (Hayden), known as "Incentives for Improving Undergraduate Teaching." Part 1 provides the background and recent history of community college faculty development. Part 2 describes the current faculty…

Construcción de un prototipo de dosificador con mezclador para el acrílico utilizado en la elaboración de prótesis temporales en odontología

OpenAIRE

Restrepo Céspedes, Andrea; Ortíz Gómez, Natalia

2009-01-01

En el proyecto de grado se describe el diseño y la implementación de un prototipo de dosificador para el acrílico utilizado en odontología para prótesis dentales -- El diseño del equipo se encuentra soportado en 4 razones principales: -Mejoramiento de la calidad del producto por una dosificación adecuada de los materiales -- Disminución de desperdicios generados a partir de errores en la dosificación -- Conservación y almacenamiento de las materias primas para la preparación del acrílico -- F...

Transcriptional Modulation of Penicillin-Binding Protein 1b, Outer Membrane Protein P2 and Efflux Pump (AcrAB-TolC during Heat Stress Is Correlated to Enhanced Bactericidal Action of Imipenem on Non-typeable Haemophilus influenzae

Directory of Open Access Journals (Sweden)

Abdessalam Cherkaoui

2018-01-01

Full Text Available Objective: The purpose of the present study was to investigate the penicillin binding proteins (PBPs, drug influx and efflux modulations during heat stress and their effects on the bactericidal action of imipenem on non-typeable Haemophilus influenzae (NTHi.Methods: The two NTHi clinical isolates (GE47 and GE88, imipenem MICs by E-test > 32 μg/mL examined in this study were collected at Geneva University Hospitals. The imipenem killing activity was assessed after incubation of the NTHi strains at either 37 or 42°C for 3 h with increasing concentrations of imipenem. The detection of PBPs was carried out by Bocillin-FL. Global transcriptional changes were monitored by RNA-seq after pre-incubation of bacterial cells at either 37 or 42°C, and the expression levels of relevant target genes were confirmed by qRT-PCR.Results: Quantitation of NTHi viable cells after incubation with 0.25 μg/mL of imipenem for 3 h revealed more than a twofold decrease in GE47 and GE88 viable cells at 42°C as compared to 37°C. Transcriptome analysis showed that under heat stress conditions, there were 141 differentially expressed genes with a | log2(fold change| > 1, including 67 up-regulated and 74 down-regulated genes. The expression levels of ponB (encoding PBP1b and acrR (regulator of AcrAB-TolC efflux pump were significantly increased at 42°C. In contrast, the transcript levels of ompP2 (encoding the outer membrane protein P2 and acrB gene (encoding AcrB were significantly lower under heat stress condition.Conclusion: This study shows that the transcriptional modulation of ponB, ompP2, acrR, and acrB in the heat stress response is correlated to enhanced antimicrobial effects of imipenem on non-typeable H. influenzae.

The prevalence of adverse cardiometabolic responses to exercise training with evidence-based practice is low

Directory of Open Access Journals (Sweden)

Dalleck LC

2015-01-01

Full Text Available Lance C Dalleck,1 Gary P Van Guilder,2 Tara B Richardson,1 Chantal A Vella3 1Recreation, Exercise, and Sport Science Department, Western State Colorado University, Gunnison, CO, USA; 2Department of Health and Nutritional Sciences, South Dakota State University, Brookings, SD, USA; 3Department of Movement Sciences, WWAMI Medical Education Program, University of Idaho, Moscow, ID, USA Background: The purpose of this study was to determine the prevalence of individuals who experienced exercise-induced adverse cardiometabolic response (ACR, following an evidence-based, individualized, community exercise program. Methods: Prevalence of ACR was retrospectively analyzed in 332 adults (190 women, 142 men before and after a 14-week supervised community exercise program. ACR included an exercise training-induced increase in systolic blood pressure of 10 mmHg, increase in plasma triglycerides (TG of >37.0 mg/dL (0.42 mmol/L, or decrease in high-density lipoprotein cholesterol (HDL-C of >4.0 mg/dL (0.12 mmol/L. A second category of ACR was also defined – this was ACR that resulted in a metabolic syndrome component (ACR-risk as a consequence of the adverse response. Results: According to the above criteria, prevalence of ACR between baseline and post-program was systolic blood pressure (6.0%, TG (3.6%, and HDL-C (5.1%. The prevalence of ACR-risk was elevated TG (3.2%, impaired fasting blood glucose (2.7%, low HDL-C (2.2%, elevated waist circumference (1.3%, and elevated blood pressure (0.6%. Conclusion: Evidence-based practice exercise programming may attenuate the prevalence of exercise training-induced ACR. Our findings provide important preliminary evidence needed for the vision of exercise prescription as a personalized form of preventative medicine to become a reality. Keywords: evidence-based research, cardiovascular health, community-based research, metabolic health

RESTAURANT RESERVATION MANAGEMENT CONSIDERING TABLE COMBINATION

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Qing Miao

Full Text Available ABSTRACT This paper presents a case study of table reservation practice for restaurant business within Walt Disney World. A unique feature here is to consider table combination to capture revenue potentials from different party sizes and at different time periods. For example, a party of large size can be served by combining two or more small tables. A mixed integer programming (MIP model is developed to make the reservation recommendation. We propose a rolling horizon reservation policy such that the value of a particular table is periodically evaluated and updated. This is a typical revenue management method in the airlines and other industries, the essence of which is to compare the future expected revenue with a currently offered price. Using historical data, numerical test shows a significant revenue improvement potential from our proposed model.

Study of Image Quality From CT Scanner Multi-Detector by using Americans College of Radiology (ACR) Phantom

Science.gov (United States)

Mulyadin; Dewang, Syamsir; Abdullah, Bualkar; Tahir, Dahlang

2018-03-01

In this study, the image quality of CT scan using phantom American College of Radiology (ACR) was determined. Scanning multidetector CT is used to know the image quality parameters by using a solid phantom containing four modules and primarily from materials that are equivalent to water. Each module is 4 cm in diameter and 20 cm in diameter. There is white alignment marks painted white to reflect the alignment laser and there are also “HEAD”, “FOOT”, and “TOP” marks on the phantom to help align. This test obtains CT images of each module according to the routine inspection protocol of the head. Acceptance of image quality obtained for determination: CT Number Accuracy (CTN), CT Number Uniformity and Noise, Linearity CT Number, Slice Technique, Low Contrast Resolution and High Contrast Resolution represent image quality parameters. In testing CT Number Accuracy (CTN), CT Uniform number and Noise are in the range of tolerable values allowed. In the test, Linearity CT Number obtained correlation value above 0.99 is the relationship between electron density and CT Number. In a low contrast resolution test, the smallest contrast groups are visible. In contrast, the high resolution is seen up to 7 lp/cm. The quality of GE CT Scan is very high, as all the image quality tests obtained are within the tolerance brackets of values permitted by the Nuclear Power Control Agency (BAPETEN). Image quality test is a way to get very important information about the accuracy of snoring result by using phantom ACR.

Improvement of organization and audit methods of production reserves at the enterprise

Directory of Open Access Journals (Sweden)

M.I. Skrypnyk

2016-12-01

Full Text Available The current research deals with the scientific substantiation of theoretical positions and development of practical recommendations for improving the organization and audit methodology of production reserves at an enterprise. The authors apply the methods of specification. Testing, analysis, synthesis, generalization are the basis for the improvement of the organization and audit methodology of production reserves at an enterprise. The researchers formulate the goals, objectives, information sources and basic methods used in the audit of production reserves. The article examines the main stages of the audit of production reserves and the methodology of its implementation. The algorithm of auditing of production reserves is defined. The paper examines the basic working papers of the auditor for auditing of production reserves such as the test on internal control of production reserves, the audit plan of production reserves, the audit program of production reserves, the comparative statement of inventory resultsof capital assets. These documents, in their turn, will increase the level of control and improve the quality of audit operations with production reserves. The article determines the common errors that occur during operations with production reserves tand you can avoid the errors using the developed plan, program and audit working papers used to conduct the audit of production reserves.

Integrating Service ­Learning and International Study into the Traditional Degree Programs

OpenAIRE

Newcomer, Quint

2010-01-01

In 2001, the University of Georgia Foundation made a significant commitment to expanding the opportunity for study abroad at UGA when it purchased a 155‐acre farm and built a new education and research center in San Luis de Monteverde, Costa Rica. UGA Costa Rica collaborates with departments and schools across the University to offer study abroad programs that offer courses directly related to major areas of study and that also integrate service‐learning as a central component of the overall ...

41 CFR 101-26.501-8 - [Reserved

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true [Reserved] 101-26.501-8 Section 101-26.501-8 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM...

77 FR 42326 - Renewal of Agency Information Collection for Indian Reservation Roads

Science.gov (United States)

2012-07-18

... Indian Reservation Roads AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice of submission to OMB... information for Indian Reservation Roads. The information collection is currently authorized by OMB Control... recognized Tribal governments to participate in the Indian Reservation Roads (IRR) program as defined in 25 U...

Petroleum production at Maximum Efficient Rate Naval Petroleum Reserve No. 1 (Elk Hills), Kern County, California

International Nuclear Information System (INIS)

1993-07-01

This document provides an analysis of the potential impacts associated with the proposed action, which is continued operation of Naval Petroleum Reserve No. I (NPR-1) at the Maximum Efficient Rate (MER) as authorized by Public law 94-258, the Naval Petroleum Reserves Production Act of 1976 (Act). The document also provides a similar analysis of alternatives to the proposed action, which also involve continued operations, but under lower development scenarios and lower rates of production. NPR-1 is a large oil and gas field jointly owned and operated by the federal government and Chevron U.SA Inc. (CUSA) pursuant to a Unit Plan Contract that became effective in 1944; the government's interest is approximately 78% and CUSA's interest is approximately 22%. The government's interest is under the jurisdiction of the United States Department of Energy (DOE). The facility is approximately 17,409 acres (74 square miles), and it is located in Kern County, California, about 25 miles southwest of Bakersfield and 100 miles north of Los Angeles in the south central portion of the state. The environmental analysis presented herein is a supplement to the NPR-1 Final Environmental Impact Statement of that was issued by DOE in 1979 (1979 EIS). As such, this document is a Supplemental Environmental Impact Statement (SEIS)

ACR/EULAR Definitions of Remission Are Associated with Lower Residual Inflammatory Activity Compared with DAS28 Remission on Hand MRI in Rheumatoid Arthritis.

Science.gov (United States)

Lisbona, Maria Pilar; Solano, Albert; Ares, Jesús; Almirall, Miriam; Salman-Monte, Tarek Carlos; Maymó, Joan

2016-09-01

To determine the level of residual inflammation [synovitis, bone marrow edema (BME), tenosynovitis, and total inflammation] quantified by hand magnetic resonance imaging (h-MRI) in patients with rheumatoid arthritis (RA) in remission according to 3 different definitions of clinical remission, and to compare these remission definitions. A cross-sectional study. To assess the level of residual MRI inflammation in remission, cutoff levels associated to remission and median scores of MRI residual inflammatory lesions were calculated. Data from an MRI register of patients with RA who have various levels of disease activity were used. These were used for the analyses: synovitis, BME according to the Rheumatoid Arthritis Magnetic Resonance Imaging Scoring system, tenosynovitis, total inflammation, and disease activity composite measures recorded at the time of MRI. Receiver-operating characteristic analysis was used to identify the best cutoffs associated with remission for each inflammatory lesion on h-MRI. Median values of each inflammatory lesion for each definition of remission were also calculated. A total of 388 h-MRI sets of patients with RA with different levels of disease activity, 130 in remission, were included. Cutoff values associated with remission according to the Simplified Disease Activity Index (SDAI) ≤ 3.3 and the Boolean American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) definitions for BME and tenosynovitis (1 and 3, respectively) were lower than BME and tenosynovitis (2 and 5, respectively) for the Disease Activity Score on 28 joints (DAS28) ≤ 2.6. Median scores for synovitis, BME, and total inflammation were also lower for the SDAI and Boolean ACR/EULAR remission criteria compared with DAS28. Patients with RA in remission according to the SDAI and Boolean ACR/EULAR definitions showed lower levels of MRI-detected residual inflammation compared with DAS28.

Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae

Directory of Open Access Journals (Sweden)

Yin Yuhan

2016-04-01

Full Text Available Abstract: INTRODUCTION: Due to the wide use of tigecycline in the treatment of severe infections caused by multidrug-resistant (MDR bacteria, clinical resistance to tigecycline has increased in recent years. Here, we investigated the relationship between tigecycline resistance and the expression of efflux pumps. METHODS: Clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae were consecutively collected from hospitalized patients in three hospitals. The minimum inhibitory concentration (MIC of tigecycline was determined using the broth microdilution method. Expression levels of efflux pump genes and regulators were examined by quantitative real-time reverse transcription polymerase chain reaction. The correlations between tigecycline MICs and gene expression levels were analyzed. RESULTS: Overall, 1,026 A. baumannii and 725 K. pneumoniae strains were collected. Most strains were isolated from sputum. The tigecycline resistance rate was 13.4% in A. baumannii isolates and 6.5% in K. pneumoniae isolates. Overexpression of AdeABC and AcrAB-TolC efflux systems was observed found in clinical tigecycline-resistant isolates. The tigecycline MIC had a linear relationship with the adeB expression level in A. baumannii isolates, but not with the acrB expression level in K. pneumoniae isolates. There were significant linear trends in the overexpression of ramA as the tigecycline MIC increased in K. pneumoniae isolates. CONCLUSIONS: Tigecycline resistance in A. baumannii and K. pneumoniae was strongly associated with the overexpression of efflux systems. More studies are needed to elucidate whether there are other regulators that affect the expression of adeB in A. baumannii and how ramA affects the expression of acrB in K. pneumoniae.

Coupling of channel thermalhydraulics and fuel behaviour in ACR-1000 safety analyses

International Nuclear Information System (INIS)

Huang, F.L.; Lei, Q.M.; Zhu, W.; Bilanovic, Z.

2008-01-01

Channel thermalhydraulics and fuel thermal-mechanical behaviour are interlinked. This paper describes a channel thermalhydraulics and fuel behaviour coupling methodology that has been used in ACR-1000 safety analyses. The coupling is done for all 12 fuel bundles in a fuel channel using the channel thermalhydraulics code CATHENA MOD-3.5d/Rev 2 and the transient fuel behaviour code ELOCA 2.2. The coupling approach can be used for every fuel element or every group of fuel elements in the channel. Test cases are presented where a total of 108 fuel element models are set up to allow a full coupling between channel thermalhydraulics and detailed fuel analysis for a channel containing a string of 12 fuel bundles. An additional advantage of this coupling approach is that there is no need for a separate detailed fuel analysis because the coupling analysis, once done, provides detailed calculations for the fuel channel (fuel bundles, pressure tube, and calandria tube) as well as all the fuel elements (or element groups) in the channel. (author)

Alternativas técnicas para o controle das alterações dimensionais das resinas acrílicas em prótese total

OpenAIRE

GOMEZ Tomas; MORI Matsuyoshi; CORRÊA Gerson de Arruda; MATSON Edmir

1998-01-01

Os autores propõem uma nova técnica para diminuição dos problemas provenientes das alterações dimensionais das resinas acrílicas utilizadas na confecção das próteses totais. Com essa proposta, conseguiu-se praticamente eliminar essas alterações dimensionais tão prejudiciais às próteses totais.

Planning for robust reserve networks using uncertainty analysis

Science.gov (United States)

Moilanen, A.; Runge, M.C.; Elith, Jane; Tyre, A.; Carmel, Y.; Fegraus, E.; Wintle, B.A.; Burgman, M.; Ben-Haim, Y.

2006-01-01

Planning land-use for biodiversity conservation frequently involves computer-assisted reserve selection algorithms. Typically such algorithms operate on matrices of species presence?absence in sites, or on species-specific distributions of model predicted probabilities of occurrence in grid cells. There are practically always errors in input data?erroneous species presence?absence data, structural and parametric uncertainty in predictive habitat models, and lack of correspondence between temporal presence and long-run persistence. Despite these uncertainties, typical reserve selection methods proceed as if there is no uncertainty in the data or models. Having two conservation options of apparently equal biological value, one would prefer the option whose value is relatively insensitive to errors in planning inputs. In this work we show how uncertainty analysis for reserve planning can be implemented within a framework of information-gap decision theory, generating reserve designs that are robust to uncertainty. Consideration of uncertainty involves modifications to the typical objective functions used in reserve selection. Search for robust-optimal reserve structures can still be implemented via typical reserve selection optimization techniques, including stepwise heuristics, integer-programming and stochastic global search.

A fonte ionizante do disco de acreção no núcleo de NGC1097

Science.gov (United States)

Silva, R. N.; Storchi-Bergmann, T.

2003-08-01

Observações em raios-X revelam o "coração" dos núcleos ativos de galáxias, pois esse tipo de radiação provém das suas regiões mais internas, próximas ao buraco negro central. Neste trabalho apresentamos observações em raios-X da região central da galáxia NGC1097, que hospeda um buraco negro supermassivo e um disco de acreção cuja emissão vem sendo observada há dez anos através da linha de emissão Ha larga (10000 km/s) e de duplo pico. As observações em raios-X - que foram obtidas com o Telescópio Chandra - foram combinadas com observações no ultravioleta obtidas com o Telescópio Espacial Hubble e são usadas para estudar as características da fonte central que ioniza o disco de acreção. A distribuição espectral de energia é comparada com a predita por modelos, em particular o de uma estrutura "ADAF" ("advection dominated accretion flow") na parte interna do disco. Tal estrutura produz um espectro de emissão de linhas estreitas tipo LINER, como observado em NGC1097 e em rádio-galáxias que apresentam linhas de Balmer largas de duplo pico. Apresentamos também uma comparação entre outros LINERs com linhas de emissão largas de duplo pico, disponíveis na literatura ou nos arquivos do Chandra e do Telescópio Espacial Hubble e discutimos as correspondentes implicações para modelos da fonte central.

[Echinococcus vogeli cysts in paca liver (Cuniculus paca) native from the Acre State, Brazil].

Science.gov (United States)

Meneghelli, U G; Martinelli, A L; Velludo, M A

1990-01-01

Four of the patients with polycystic hydatid disease observed by us reported that they were aware of the presence of liver disease in the pacas hunted for food. The viscera of these animals were usually given to domestic dogs. All of our 7 patients reported contact with dogs that had previously ingested viscera of pacas. Examination of the liver considered to be diseased by one of the patients and removed from a paca killed in the same region (State of Acre, Brazil) from which the human cases originated showed the presence of hydatid cysts. The characteristics of the rostellar hooks of the protoscolex indicated that this was the larval form of Echinococcus vogeli. These observations confirm the participation of pacas in the biological cycle of E. vogeli and the pathway through which man may become an alternative intermediate host of this echinococcus.

Seasonal use of conservation reserve program lands by white-tailed deer in east-central South Dakota

Science.gov (United States)

Gould, Jeffrey H.; Jenkins, Kurt J.

1993-01-01

The Conservation Reserve Program (CRP_, a provision of the 1985 Food Security Act, subsidizes landowners to take highly erodible lands out of cultivation and seed them to perennial cover for 10years. In eastern South Dakota, 0.5 million ha were enrolled in the CRP from 1985 to 1990 (Agric. Stabilization and Conserv. Serv., Brookings, S.D., unpubl. Data), which represents the largest change in conservation land-use practices in the region since the 1956 Soil Bank Program (Goetz 1987).Although the CRP is anticipated to produce substantial benefits for some wildlife species, particularly ground-nesting birds, its significance to white-tailed deer (Odocoileus virginianus) in the northern Great Plains agricultural region is poorly understood. Higgins et al. (1987) speculated that proliferation of CRP grasslands may provide a missing habitat component in intensively managed farmland, thereby enhancing several species of wildlife, including white-tailed deer. Deer managers in the region have expressed concerns that improved cover associated with DRP plantings on private land could attract deer and reduce hunter success rates or lead to increased depredation of adjacent croplands or stored winter forages (L. Rice, S.D. Dep. Game, Fish, and Parks, Rapid City, pers. comm., 1989). Our objectives were to describe variation in deer use of CRP lands by season, diel period, and deer activity class as a means of assessing seasonal importance of CRP fields to white-tailed deer in agricultural Midwest.

The situation of radiation oncology practice training programs and their graduates in 1998

International Nuclear Information System (INIS)

Bushee, Gerald R.; Sunshine, Jonathan H.; Schepps, Barbara

2000-01-01

Purpose: To keep the profession apprised of current trends in the job market, the American College of Radiology (ACR) studied the employment situation of 1998 radiation oncology graduates and the status and plans of radiation oncology training programs in the United States. Methods and Materials: In April-May 1998, and again in a December 1998-January 1999 follow-up, the ACR surveyed all radiation oncology residency directors in the U.S. about the employment situation of their 1998 residency and fellowship graduates as well as changes in their programs. Eighty-five percent (71/84) of those surveyed responded. We compare current findings with similar 1997 and earlier surveys and report statistically significant differences (p ≤ 0.05). Results: By 6 months after graduation, there were no graduating residents or fellows who had not secured a position, although the status of two was unknown. At that time, about 93% of all graduates had secured positions that directors said reasonably matched graduates' training and personal goals. Program directors reported that accomplished and planned changes in their programs will reduce the annual number of residency graduates by about one-fifth since 1993. However, the number of beginning residency positions offered in 1998 was 149, up from 116 in 1997 and only a few percent below the 1993 level. By the December 1998-January 1999 follow-up, fill rates for offered training positions were 94% for residencies and 80% for fellowships, figures that are similar to those reported for past years. Directors' perceptions of the job market are much more positive. For example, only 11% of residency directors viewed the market as more difficult this year than typical of recent years, as against 48% in 1997 and 82% in 1996. Conclusion: Unemployment continues to be low, and another, 'softer' indicator, the job market perceptions of residency program directors, continues to improve. Possibly as a result, plans for program reductions are

Análise do processo de gestão no setor de habitação: o caso COHAB/Acre

Directory of Open Access Journals (Sweden)

Ângela Maria Bessa Fleming

2010-05-01

Full Text Available Este artigo é uma síntese da dissertação de mestrado, visando esclarecer as facilidades e dificuldades encontradas pela Companhia de Habitação do Estado do Acre, no que concerne à elaboração, implantação e execução de um Modelo de Gestão para o Setor Habitacional que seja capaz de modernizar-se, contemplando a reestruturação organizacional e a viabilidade de ações estratégicas no avanço dos projetos de engenharia e inclusão social. Estes projetos teriam como finalidade a redução do déficit habitacional e sua maior participação na formulação das políticas públicas no Estado do Acre. O artigo discute a articulação conjunta do Planejamento Estratégico e a Gestão Estratégica, tomando como referências as proposições de vários autores, estudiosos e pesquisadores na área de estratégia empresarial. Quanto à formulação da gestão pública, ressalta-se a importância de se resgatar a história da habitação no Brasil no equacionamento da problemática social. Vale ressaltar o papel do Banco Nacional de Habitação - BNH na construção de uma política desenvolvimentista para o setor, além de explicitar as dificuldades e desafios enfrentados pelas Companhias de Habitação em todo o país - COHABs. Sinaliza-se uma saída para a empresa de economia mista, no sentido retomar seu papel social, econômico e político diante da realidade regional. Sugere-se a integração e a aliança estratégica da Companhia de Habitação do Estado do Acre com os governos federal, estadual e municipal de modo a intensificar, ainda mais, sua participação no processo de desenvolvimento social e econômico da Amazônia.

Oak Ridge Reservation Federal Facility Agreement. Quarterly report for the Environmental Restoration Program. Volume 4, July 1995--September 1995

International Nuclear Information System (INIS)

1995-10-01

This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program that are specified in the Oak Ridge Reservation Federal Facility Agreement (FFA) established between the U.S. Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered herein is July through September 1995 (fourth quarter of FY 1995). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been approved as FY 1995 commitments

Atividade sexual e doenças sexualmente transmissíveis em escolares do 2º grau de Rio Branco-Acre, Brasil La actividad sexual y las enfermedades sexualmente trasmisibles en estudiantes de segundo grado (estudios secundarios de Rio Branco-Acre, Brasil Sexual activity and sexually transmissible diseases of high school students in Rio Branco-Acre, Brasil

Directory of Open Access Journals (Sweden)

Luiz Carlos Souza do Nascimento

2000-01-01

Full Text Available Este estudo foi realizado junto a 2.684 alunos do Segundo Grau de Rio Branco¾Acre, Brasil, para verificar aspectos da atividade sexual e a ocorrência de DST/AIDS. Dos alunos pesquisados, 48,9% tiveram relações sexuais, sendo que para o sexo masculino o início mais freqüente foi aos 13 anos, representando 34,3% e para o feminino foi aos 16 anos, com 31,6%. Da ocorrência de DST/AIDS mencionadas 58,4% foi para a Hepatite B, 39,4% para a Monilíase e 2,2% para a Gonorréia. Dos que tiveram relações sexuais 47,6% foi com o/a namorado/a, 25,8% com o/a vizinho/a e 10,5% com a empregada doméstica. Como conclusão, 52,3% dos alunos das escolas particulares, 50,0% da federal, 45,7% das estaduais e 41,8% da municipal, tiveram relação sexual.Este estudio se realizó con 2.684 estudiantes de secundaria de Rio Branco-Acre, Brasil, para verificar los aspectos de la actividad sexual y la incidencia de ETS/SIDA. De los estudiantes investigados 48,9% tuvieron relaciones sexuales. De ellos el 34,3% pertenecen al sexo masculino y empezaron a los 13 años de edad. 31,6% son del sexo femenino e iniciaron su vida sexual a los 16 años. De la incidencia referida de ETS/SIDA el 58,4% fue para Hepatitis B, el 39,4% para Candidiasis y el 2,2% para Gonorrea. De los que tuvieron relaciones sexuales, el 47,6% fue con el novio (¾a; el 25,8% con el vecino (-a y el 10,5% con la empleada domestica de la casa. Por lo tanto, se concluye que el 52,3% de los alunnos de las escuelas privadas, el 50,0% de la federal, el 45,7% de las estatales y el 41,8% de las municipales (provinciales tuvieron relación sexual.This study was realized with 2.684 students of the high school in Rio Branco¾Acre, Brazil, to verify aspects of the sexual activity and the occurrence of DST/AIDS. From the researched students, 48,9% had sexual intercourses, and the largest frequency was 34,3% for male sex, with the beginning at 13 years old, and for female sex 31,6%, with the beginning at 16

Liquidity implications of a commitment period reserve at national and global levels

International Nuclear Information System (INIS)

Haites, Erik; Missfeldt, Fanny

2004-01-01

The Kyoto Protocol, if it enters into force, will establish international emissions trading for quota that can be used for compliance with Protocol commitments. Concern that the non-compliance regime might not be sufficient to deter overselling led to adoption of the commitment period reserve requirement. This paper analyses the commitment period reserve in terms of (a) the liquidity of the international emissions trading market, and (b) international liquidity for domestic emissions trading programs in Annex B countries. The liquidity of the international greenhouse gas emissions trading market is measured as the sum of the quota surplus to the reserve requirement of net seller countries divided by the average annual assigned amount of all Annex B Parties and by the BAU emissions of Annex B Parties. Both measures are calculated using both the average values across 500 projections of future emissions and the values that yield the lowest liquidity (lowest reserves, highest emissions). Even the lowest estimates indicate liquidity comparable to that of the existing emissions trading programs. In addition, the international liquidity for domestic emissions trading programs with the commitment period reserve is likely to be comparable to or better than that of existing emissions trading markets, even under conservative assumptions

Research Experience for Undergraduates Program in Multidisciplinary Environmental Science

Science.gov (United States)

Wu, M. S.

2012-12-01

During summers 2011 and 12 Montclair State University hosted a Research Experience for Undergraduates Program (REU) in transdisciplinary, hands-on, field-oriented research in environmental sciences. Participants were housed at the Montclair State University's field station situated in the middle of 30,000 acres of mature forest, mountain ridges and freshwater streams and lakes within the Kittatinny Mountains of Northwest New Jersey, Program emphases were placed on development of project planning skills, analytical skills, creativity, critical thinking and scientific report preparation. Ten students were recruited in spring with special focus on recruiting students from underrepresented groups and community colleges. Students were matched with their individual research interests including hydrology, erosion and sedimentation, environmental chemistry, and ecology. In addition to research activities, lectures, educational and recreational field trips, and discussion on environmental ethics and social justice played an important part of the program. The ultimate goal of the program is to facilitate participants' professional growth and to stimulate the participants' interests in pursuing Earth Science as the future career of the participants.

Carbon debt of Conservation Reserve Program (CRP) grasslands converted to bioenergy production.

Science.gov (United States)

Gelfand, Ilya; Zenone, Terenzio; Jasrotia, Poonam; Chen, Jiquan; Hamilton, Stephen K; Robertson, G Philip

2011-08-16

Over 13 million ha of former cropland are enrolled in the US Conservation Reserve Program (CRP), providing well-recognized biodiversity, water quality, and carbon (C) sequestration benefits that could be lost on conversion back to agricultural production. Here we provide measurements of the greenhouse gas consequences of converting CRP land to continuous corn, corn-soybean, or perennial grass for biofuel production. No-till soybeans preceded the annual crops and created an initial carbon debt of 10.6 Mg CO(2) equivalents (CO(2)e)·ha(-1) that included agronomic inputs, changes in C stocks, altered N(2)O and CH(4) fluxes, and foregone C sequestration less a fossil fuel offset credit. Total debt, which includes future debt created by additional changes in soil C stocks and the loss of substantial future soil C sequestration, can be constrained to 68 Mg CO(2)e·ha(-1) if subsequent crops are under permanent no-till management. If tilled, however, total debt triples to 222 Mg CO(2)e·ha(-1) on account of further soil C loss. Projected C debt repayment periods under no-till management range from 29 to 40 y for corn-soybean and continuous corn, respectively. Under conventional tillage repayment periods are three times longer, from 89 to 123 y, respectively. Alternatively, the direct use of existing CRP grasslands for cellulosic feedstock production would avoid C debt entirely and provide modest climate change mitigation immediately. Incentives for permanent no till and especially permission to harvest CRP biomass for cellulosic biofuel would help to blunt the climate impact of future CRP conversion.

DIAGNÓSTICO SÓCIO-ECONÔMICO DA PISCICULTURA PRATICADA POR PEQUENOS PRODUTORES DA REGIONAL DO BAIXO ACRE.

OpenAIRE

Sa, Claudenor Pinho De; Balzon, Tatiana; Oliveira, Tony John; Bayma, Marcio Muniz Albano; Carneiro Junior, Jose Marques

2008-01-01

Este trabalho propõe analisar o desempenho financeiro da piscicultura no sistema semi-intensivo, praticado por pequenos produtores da regional do Baixo Acre e avaliar os fatores que atuam como ameaças ao desenvolvimento da cadeia produtiva. A análise financeira foi realizada com o método do orçamento e como indicadores foram utilizados a renda líquida, o custo unitário de produção e a remuneração da mão de obra familiar. Para os fatores de risco, utilizou-se uma adaptação do método Zoop, deno...

77 FR 73 - Cooperative Conservation Partnership Initiative and Wetlands Reserve Enhancement Program

Science.gov (United States)

2012-01-03

... conservation program funds and mechanisms in support of the objectives of MRBI. Through agreements, partners... objectives. Include the name of the program and the associated Federal agency. (Note: Federal funds cannot be used as a match to the funds provided by NRCS.) (2) Project Natural Resource Objectives and Concerns...

Northern Cheyenne Reservation Coal Bed Natural Resource Assessment and Analysis of Produced Water Disposal Options

Energy Technology Data Exchange (ETDEWEB)

Shaochang Wo; David A. Lopez; Jason Whiteman Sr.; Bruce A. Reynolds

2004-07-01

Coalbed methane (CBM) development in the Powder River Basin (PRB) is currently one of the most active gas plays in the United States. Monthly production in 2002 reached about 26 BCF in the Wyoming portion of the basin. Coalbed methane reserves for the Wyoming portion of the basin are approximately 25 trillion cubic feet (TCF). Although coal beds in the Powder River Basin extend well into Montana, including the area of the Northern Cheyenne Indian Reservation, the only CBM development in Montana is the CX Field, operated by the Fidelity Exploration, near the Wyoming border. The Northern Cheyenne Reservation is located on the northwest flank of the PRB in Montana with a total land of 445,000 acres. The Reservation consists of five districts, Lame Deer, Busby, Ashland, Birney, and Muddy Cluster and has a population of 4,470 according to the 2000 Census. The CBM resource represents a significant potential asset to the Northern Cheyenne Indian Tribe. Methane gas in coal beds is trapped by hydrodynamic pressure. Because the production of CBM involves the dewatering of coalbed to allow the release of methane gas from the coal matrix, the relatively large volume of the co-produced water and its potential environmental impacts are the primary concerns for the Tribe. Presented in this report is a study conducted by the Idaho National Engineering and Environmental Laboratory (INEEL) and the Montana Bureau of Mines and Geology (MBMG) in partnership with the Northern Cheyenne Tribe to assess the Tribe’s CBM resources and evaluate applicable water handling options. The project was supported by the U.S. Department of Energy (DOE) through the Native American Initiative of the National Petroleum Technology Office, under contract DEAC07- 99ID13727. Matching funds were granted by the MBMG in supporting the work of geologic study and mapping conducted at MBMG.

Porta-enxertos para laranjeiras-doces (Citrus sinensis (L. Osb., em Rio Branco, Acre Rootstocks for sweet orange (Citrus sinensis (L. Osb. in Rio Branco, Acre, Brazil

Directory of Open Access Journals (Sweden)

Ana da Silva Ledo

1999-07-01

Full Text Available O objetivo deste trabalho foi de avaliar o comportamento de sete cultivares de laranjeiras- doces: 'Baia 101', 'Baianinha IAC 79', 'Monte Parnaso', 'Pêra D6', 'Natal 112', 'Valência 27' e 'Aquiri', sobre diferentes porta-enxertos: limão 'Cravo', tangerinas 'Cleópatra' e 'Sunki' e citrange 'Carrizo', nas condições edafoclimáticas de Rio Branco, Acre. O delineamento experimental foi em parcelas subdivididas, com as cultivares nas parcelas, os porta-enxertos nas subparcelas e os quatro anos de avaliação como repetições. As laranjeiras 'Pêra D6', 'Natal 112' e 'Valência 27' apresentaram tendências de maior produção quando enxertadas sobre o limão 'Cravo', e a laranja 'Aquiri' quando enxertada sobre citrange 'Carrizo'. Em relação aos demais porta-enxertos, o limão 'Cravo' mostrou tendências de induzir maior produção/volume de copa e peso médio do fruto, e menor teor de sólidos solúveis totais e acidez total. As laranjas do grupo Baia ('Baia 101', 'Baianinha IAC 79' e 'Monte Parnaso' produziram frutos com baixa percentagem de suco; não são recomendadas para plantio em Rio Branco, AC. Com base nos resultados obtidos, recomendam-se os porta-enxertos citrange 'Carrizo', tangerina 'Cleópatra' e limão 'Cravo' para a laranja 'Aquiri', e o porta-enxerto limão 'Cravo' para as laranjas 'Pêra D6', 'Natal 112' e 'Valência 27'.The objective of this study was to evaluate the behaviour of seven sweet orange cultivars: 'Baia 101', 'Baianinha IAC 79', 'Monte Parnaso', 'Pêra D6', 'Natal 112', 'Valência 27' and 'Aquiri' grafted on different rootstocks: 'Rangpur' lime, 'Cleópatra' and 'Sunki' mandarins, and 'Carrizo' citrange, in the environmental conditions of Rio Branco, Acre, Brazil. The experimental design was a split-plot, with the sweet orange cultivars as the main plots, the rootstocks as the sub-plots, and the four years of evaluation as replications. The 'Pêra D6', 'Natal 112' and 'Valência 27' sweet orange cultivars tended

Petrology and chemistry of the Green Acres gabbro complex near Winchester, Riverside County, California

Science.gov (United States)

Berger, Byron R.; Morton, Douglas M.; Miller, Fred K.

2014-01-01

The Cretaceous Green Acres layered igneous complex, northeast of Winchester, California, is composed of a suite of olivine- and hornblende-bearing gabbros in the Peninsular Ranges batholith within the Perris tectonic block. A consistent mineral assemblage is observed throughout the complex, but there is considerable textural and modal heterogeneity. Both preclude a consistent set of principles based on appearance and mineralogy on which to delineate map units. Distinct changes in the chemistry of olivine, pyroxene, and hornblende, however, serve to define discrete mappable units, and the complex has been divided into five geochemical map units on this basis.Limited whole-rock data show the Green Acres complex is chemically comparable to other Peninsular Ranges batholith gabbroic rocks, and rare earth element (REE) concentrations and patterns are typical of magmas generated in convergent margin settings. For the complex as a whole, olivine is Fo80–35, plagioclase is An100–64, clinopyroxene is Wo49–41En48–38Fs18–6 and Wo36–26En65–42Fs30–8, and orthopyroxene is Wo5–0En78–42Fs50–21, where Fo is forsterite, An is anorthite, Wo is wollastonite, En is enstatite, and Fs is ferrosilite. The Mg/(Mg + ΣFe) atomic ratio in hornblende ranges from 0.84 to 0.50.Magmatic lineations and modal and textural layering are prevalent throughout the complex. Mineral chemistry does not change in any systematic way within and between layers in any map unit. Although the strike of layering varies, in any map unit at any given location it is the same in all units irrespective of intrusive order. Thin dikes, typically late-stage hornblende gabbro, commonly intrude parallel to layering. The strikes of magmatic lineations and modal layers are consistent with the populations of strikes of fabrics in the metamorphic basement as well as tectonic features in surrounding, postgabbro granitic rocks. These relations imply that the regional state of stress at the time of gabbro

Coeur d'Alene Tribe Fisheries Program : Implementation of Fisheries Enhancement Opportunities on the Coeur d’Alene Reservation : 2007 Annual Report.

Energy Technology Data Exchange (ETDEWEB)

Firehammer, Jon A.; Vitale, Angelo J.; Hallock, Stephanie A. [Coeur d' Alene Tribe Department of Natural Resources Fisheries Program

2009-09-08

diversity, and increase the probability of persistence in the face of anthropogenic influences and prospective climate change. This included recovering the lacustrine-adfluvial life history form that was historically prevalent and had served to provide both resilience and resistance to the structure of cutthroat trout populations in the Coeur d'Alene basin. To this end, the Coeur d'Alene Tribe closed Lake Creek and Benewah Creek to fishing in 1993 to initiate recovery of westslope cutthroat trout to historical levels. However, achieving sustainable cutthroat trout populations also required addressing biotic factors and habitat features in the basin that were limiting recovery. Early in the 1990s, BPA-funded surveys and inventories identified limiting factors in Tribal watersheds that would need to be remedied to restore westslope cutthroat trout populations. The limiting factors included: low-quality, low-complexity mainstem stream habitat and riparian zones; high stream temperatures in mainstem habitats; negative interactions with nonnative brook trout in tributaries; and potential survival bottlenecks in Coeur d'Alene Lake. In 1994, the Northwest Power Planning Council adopted the recommendations set forth by the Coeur d'Alene Tribe to improve the Reservation fishery (NWPPC Program Measures 10.8B.20). These recommended actions included: (1) Implement habitat restoration and enhancement measures in Alder, Benewah, Evans, and Lake Creeks; (2) Purchase critical watershed areas for protection of fisheries habitat; (3) Conduct an educational/outreach program for the general public within the Coeur d'Alene Reservation to facilitate a 'holistic' watershed protection process; (4) Develop an interim fishery for tribal and non-tribal members of the reservation through construction, operation and maintenance of five trout ponds; (5) Design, construct, operate and maintain a trout production facility; and (6) Implement a monitoring program to

First molecular identification of Echinococcus vogeli and Echinococcus granulosus (sensu stricto) G1 revealed in feces of domestic dogs (Canis familiaris) from Acre, Brazil.

Science.gov (United States)

das Neves, Leandro Batista; Teixeira, Paulo Eduardo Ferlini; Silva, Sidnei; de Oliveira, Fernanda Bittencourt; Garcia, Daniel Daipert; de Almeida, Fernanda Barbosa; Rodrigues-Silva, Rosângela; Machado-Silva, José Roberto

2017-01-14

Echinococcus granulosus (sensu lato) (s.l.) and Echinococcus vogeli are causative agents of chronic zoonotic diseases such as cystic and polycystic echinococcosis, respectively. In Brazil, polycystic echinococcosis has a restricted geographical distribution in the North Region, while cystic echinococcosis is observed in the South Region. Domestic dogs (Canis familiaris) fed with raw viscera represent a risk factor for E. granulosus (s.l.) infection in the South Region. Although this practice is frequent, it remains unclear whether domestic dogs are infected with E. vogeli in the state of Acre, located in the Amazon basin in the North Region of Brazil. The aim of this study was to investigate this gap in the polycystic echinococcosis epidemiology. Sixty-five fecal samples were collected from the ground in five municipalities (Sena Madureira, n = 14; Rio Branco, n = 06; Bujari, n = 06; Xapuri, n = 30; and Epitaciolândia, n = 09) located in the state of Acre, northern Brazil. The samples were screened for parasites by copro-PCR using the cox1 gene associated with automated sequencing. Echinococcus vogeli was molecularly confirmed in a sample from Sena Madureira and E. granulosus (sensu stricto) (s.s.) (G1) in a sample from Rio Branco. These findings indicate that molecular assays are useful in typing Echinococcus taxa from fecal samples of dogs in northern Brazil. The present study is the first molecular record of E. vogeli in domestic dogs found in the state of Acre, reinforcing their role as a source of infection for humans. Because E. granulosus (s.s.) (G1) was detected for the first time in the North Region, from the epidemiological standpoint this finding is highly relevant, because it expands the known geographical distribution, which was previously restricted to the South Region of Brazil.