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Sample records for reserve engineering approach

  1. Thermodynamics an engineering approach

    CERN Document Server

    Cengel, Yunus A

    2014-01-01

    Thermodynamics, An Engineering Approach, eighth edition, covers the basic principles of thermodynamics while presenting a wealth of real-world engineering examples so students get a feel for how thermodynamics is applied in engineering practice. This text helps students develop an intuitive understanding by emphasizing the physics and physical arguments. Cengel and Boles explore the various facets of thermodynamics through careful explanations of concepts and use of numerous practical examples and figures, having students develop necessary skills to bridge the gap between knowledge and the confidence to properly apply their knowledge. McGraw-Hill is proud to offer Connect with the eighth edition of Cengel/Boles, Thermodynamics, An Engineering Approach. This innovative and powerful new system helps your students learn more efficiently and gives you the ability to assign homework problems simply and easily. Problems are graded automatically, and the results are recorded immediately. Track individual stude...

  2. Engineering Students' Sustainability Approaches

    Science.gov (United States)

    Haase, S.

    2014-01-01

    Sustainability issues are increasingly important in engineering work all over the world. This article explores systematic differences in self-assessed competencies, interests, importance, engagement and practices of newly enrolled engineering students in Denmark in relation to environmental and non-environmental sustainability issues. The…

  3. Nonlinear Approaches in Engineering Applications

    CERN Document Server

    Jazar, Reza

    2012-01-01

    Nonlinear Approaches in Engineering Applications focuses on nonlinear phenomena that are common in the engineering field. The nonlinear approaches described in this book provide a sound theoretical base and practical tools to design and analyze engineering systems with high efficiency and accuracy and with less energy and downtime. Presented here are nonlinear approaches in areas such as dynamic systems, optimal control and approaches in nonlinear dynamics and acoustics. Coverage encompasses a wide range of applications and fields including mathematical modeling and nonlinear behavior as applied to microresonators, nanotechnologies, nonlinear behavior in soil erosion,nonlinear population dynamics, and optimization in reducing vibration and noise as well as vibration in triple-walled carbon nanotubes. This book also: Provides a complete introduction to nonlinear behavior of systems and the advantages of nonlinearity as a tool for solving engineering problems Includes applications and examples drawn from the el...

  4. Synthetic biology approaches to engineer T cells.

    Science.gov (United States)

    Wu, Chia-Yung; Rupp, Levi J; Roybal, Kole T; Lim, Wendell A

    2015-08-01

    There is rapidly growing interest in learning how to engineer immune cells, such as T lymphocytes, because of the potential of these engineered cells to be used for therapeutic applications such as the recognition and killing of cancer cells. At the same time, our knowhow and capability to logically engineer cellular behavior is growing rapidly with the development of synthetic biology. Here we describe how synthetic biology approaches are being used to rationally alter the behavior of T cells to optimize them for therapeutic functions. We also describe future developments that will be important in order to construct safe and precise T cell therapeutics. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Project Supervision - An Engineering Approach

    DEFF Research Database (Denmark)

    Paulsen, Rasmus Reinhold; Larsen, Rasmus; Ersbøll, Bjarne Kjær

    2011-01-01

    For more than twenty years, a group based supervision strategy has been used when supervising engineering bachelor- and master thesis students at our research group. In recent years, we have formalised the approach and used our industry experience to create a very successful framework for project...... supervision. This paper is a best practice guide aiming at research groups that would like to try to implement our supervision approach or parts of it. The approach is based on the belief that engineering students should be prepared for their new role as development engineers or PhD students as part...... of their master thesis writing. The supervision principles are: Ownership: The student should feel that their project is their own. Ideally, they should formulate the project themselves. Write early: We strongly encourage the students to write and generate figures and images already from the first week...

  6. Fundamental Approaches to Software Engineering

    NARCIS (Netherlands)

    Gnesi, S.; Rensink, Arend; Unknown, [Unknown

    This volume contains the proceedings of FASE 2014, the 17th International Conferences on Fundamental Approaches to Software Engineering, which was held in Grenoble, Italy, in April 2014 as part of the annual European Joint Conferences on Theory and Practice of Software (ETAPS).

  7. Interdisciplinary Approach in Engineering Education

    Directory of Open Access Journals (Sweden)

    Anda Zeidmane

    2011-04-01

    Full Text Available The analysis of the scientific literature available on the types of general competences and their classification caused the authors to conclude that it is necessary to implement interdisciplinary approach in engineering education to develop competences necessary for engineers to make them competitive in the labour market. The attention should be paid to a professional foreign language, computer literacy and educational psychology recommendations. To improve professional foreign language skills, CLIL (Content and Language Integrated Learning method should be integrated in the study process of engineering education. In order to develop information literacy competence, it is important to create a single e-study environment. The academic staff, developing study subjects for engineering programmes, should focus on the study content and study methods. As regards the content, the compromise should be sought between fundamental acquisition of the knowledge of the subject matter, the know-how of the application of this knowledge as well as the use of brand new software in the calculations. The paper presents the examples of the application of the interdisciplinary approach in the universities, where the authors of the paper are affiliated: the LUA (Latvia University of Agriculture and the RTU (Riga Technical University, respectively.

  8. an alternative approach to t reservations for hand ative approach

    African Journals Online (AJOL)

    eobe

    using the Gaussian Elimination method. Key words: Key words: GSM, resource reservation, quality of ser. 1. INTRODUCTION. INTRODUCTION. INTRODUCTION. In a typical cellular network, the radio and fixed l required are not permanently allocated for duration of a call. Handover, which is also referre as handoff in North ...

  9. Engineering geology studies in the National Petroleum Reserve, Alaska

    Science.gov (United States)

    Kachadoorian, Reuben; Crory, F.E.

    1984-01-01

    Engineering geology studies were conducted in direct support of the exploration program in the National Petroleum Reserve, Alaska. The studies included laboratory and field tests and observations to address design and construction problems of airfields, roads, drill pads and foundations, and to evaluate their actual performance. Permafrost containing large amounts of near surface ground ice as wedges, masses, and intergranular ice, required that all construction activity not disturb the thermal regime of the ground surface, which could lead to thaw of permafrost and ground subsidence. Summer activity, therefore was not allowable, yet the winter climate was so harsh that winter work was slow and inefficient. To allow summer operations at well sites planned for all year activity, it was necessary to adapt existing techniques for arctic construction and to devise new ones. The design and construction of facilities at the deep exploration wells at Inigok, Tunalik, and Lisburne posed the greatest challenge. These sites, requiring a year or more to drill, could only be attempted if continuous access to drilling and logistic supplies could be assured throughout the year, including the possibility of bringing in another drill rig, in the event of a blowout. Thus all-seasons airstrips were required at these wells. Sufficient quantities of local gravel were not readily available at the Inigok and Tunalik sites to construct the airstrips with the required 6 feet or more of gravel to prevent the underlying permafrost from thawing. Therefore, insulation was used to maintain the subbase of local sands in a continuously frozen state, which in turn was overlain by 15 inches of gravel or sandy gravel. Tests at the U.S. Army Waterways Experimental Station defined the minimum thickness of gravel required above the insulation to provide the desired bearing capacity for the C-130 type aircraft without crushing the insulation. Field testing also included the evaluation of another design

  10. New approaches to e-reserve linking, sharing and streaming

    CERN Document Server

    Cheung, Ophelia; Patrick, Susan

    2010-01-01

    Aimed at academic library practitioners, this book describes how e-reserve services can evolve and adapt to the changing virtual learning environment of higher education. New approaches discussed include: the integration of subscribed, free, and copyrighted resources within course management systems; innovative employment of open URL link resolvers to connect e-reserve with library e-resources and services; video streaming within course documents; and the creative use of bibliographic software to produce customized reading lists. New Approaches to E-Reserve includes detailed descriptions and e

  11. Nonlinear approaches in engineering applications 2

    CERN Document Server

    Jazar, Reza N

    2013-01-01

    Provides updated principles and applications of the nonlinear approaches in solving engineering and physics problems Demonstrates how nonlinear approaches may open avenues to better, safer, cheaper systems with less energy consumption Has a strong emphasis on the application, physical meaning, and methodologies of nonlinear approaches in different engineering and science problems

  12. Rethinking engineering education the CDIO approach

    CERN Document Server

    Crawley, Edward F; Östlund, Sören; Brodeur, Doris R; Edström, Kristina

    2014-01-01

    This book describes an approach to engineering education that integrates a comprehensive set of personal, interpersonal, and professional engineering skills with engineering disciplinary knowledge in order to prepare innovative and entrepreneurial engineers.  The education of engineers is set in the context of engineering practice, that is, Conceiving, Designing, Implementing, and Operating (CDIO) through the entire lifecycle of engineering processes, products, and systems. The book is both a description of the development and implementation of the CDIO model and a guide to engineering programs worldwide that seek to improve the education of young engineers.   Provides an overview of the CDIO approach, then chapters organized according to the CDIO Standards; Includes in each chapter objectives, discussion questions, case studies and clear diagrams to support key concepts and processes; Avoids the jargon of education specialists and clearly explains education terms in the context of their initial presentatio...

  13. Software engineering a practitioner's approach

    CERN Document Server

    Pressman, Roger S

    1997-01-01

    This indispensable guide to software engineering exploration enables practitioners to navigate the ins and outs of this rapidly changing field. Pressman's fully revised and updated Fourth Edition provides in-depth coverage of every important management and technical topic in software engineering. Moreover, readers will find the inclusion of the hottest developments in the field such as: formal methods and cleanroom software engineering, business process reengineering, and software reengineering.

  14. Extended Reconstruction Approaches for Saturation Measurements Using Reserved Quantization Indices

    DEFF Research Database (Denmark)

    Li, Peng; Arildsen, Thomas; Larsen, Torben

    2012-01-01

    This paper proposes a reserved quantization indices method for saturated measurements in compressed sensing. The existing approaches tailored for saturation effect do not provide a way to identify saturated measurements, which is mandatory in practical implementations.We introduce a method using...

  15. An approach to studying the neural correlates of reserve

    Science.gov (United States)

    Stern, Yaakov

    2018-01-01

    The goal of this paper is to review my current understanding of the concepts of cognitive reserve (CR), brain reserve and brain maintenance, and to describe our group’s approach to using imaging to study their neural basis. I present a working model for utilizing data regarding brain integrity, clinical status, cognitive activation and CR proxies to develop analyses that can explore the neural basis of cognitive reserve and brain maintenance. The basic model assumes that the effect of brain changes on cognition is mediated by task-related activation. We treat CR as a moderator to understand how task-related activation might vary as a function of CR, or how CR might operate independently of these differences in task-related activation. My hope is that this presentation will spark discussion across groups that study these concepts, allowing us to come to some common agreement on definitions, methodology and approaches. PMID:27450378

  16. Combined additive manufacturing approaches in tissue engineering.

    Science.gov (United States)

    Giannitelli, S M; Mozetic, P; Trombetta, M; Rainer, A

    2015-09-01

    Advances introduced by additive manufacturing (AM) have significantly improved the control over the microarchitecture of scaffolds for tissue engineering. This has led to the flourishing of research works addressing the optimization of AM scaffolds microarchitecture to optimally trade-off between conflicting requirements (e.g. mechanical stiffness and porosity level). A fascinating trend concerns the integration of AM with other scaffold fabrication methods (i.e. "combined" AM), leading to hybrid architectures with complementary structural features. Although this innovative approach is still at its beginning, significant results have been achieved in terms of improved biological response to the scaffold, especially targeting the regeneration of complex tissues. This review paper reports the state of the art in the field of combined AM, posing the accent on recent trends, challenges, and future perspectives. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  17. Social Engineering a General Approach

    OpenAIRE

    Valerica GREAVU-SERBAN; Oana SERBAN

    2014-01-01

    Social engineering is considered to be a taboo subject in nowadays society. It involves the use of social skills or to obtain usernames, passwords, credit card data, or to compromise or altering the information and systems of an entity. Social engineering methods are numerous and people using it are extremely ingenious and adaptable. This technique takes advantage of the intrinsic nature of mankind, to manipulate and obtain sensitive information, persuading people into divulge it, using excep...

  18. Social Engineering a General Approach

    Directory of Open Access Journals (Sweden)

    Valerica GREAVU-SERBAN

    2014-01-01

    Full Text Available Social engineering is considered to be a taboo subject in nowadays society. It involves the use of social skills or to obtain usernames, passwords, credit card data, or to compromise or altering the information and systems of an entity. Social engineering methods are numerous and people using it are extremely ingenious and adaptable. This technique takes advantage of the intrinsic nature of mankind, to manipulate and obtain sensitive information, persuading people into divulge it, using exceptional communication skills. Thus, five models of persuasion were identified, based on: simplicity, interest, incongruity, confidence and empathy, exploiting key factors which predispose people to fall victim to attacks of social engineering such as greed, self-interest, guilt or ignorance. It is well known fact that security is as strong as the weakest link in its chain (individuals therefore, beyond technical measures, staff training is the key to success in defending against such attacks.

  19. Advanced computational approaches to biomedical engineering

    CERN Document Server

    Saha, Punam K; Basu, Subhadip

    2014-01-01

    There has been rapid growth in biomedical engineering in recent decades, given advancements in medical imaging and physiological modelling and sensing systems, coupled with immense growth in computational and network technology, analytic approaches, visualization and virtual-reality, man-machine interaction and automation. Biomedical engineering involves applying engineering principles to the medical and biological sciences and it comprises several topics including biomedicine, medical imaging, physiological modelling and sensing, instrumentation, real-time systems, automation and control, sig

  20. Externally heated valve engine a new approach to piston engines

    CERN Document Server

    Kazimierski, Zbyszko

    2016-01-01

    This book reports on a novel approach for generating mechanical energy from different, external heat sources using the body of a typical piston engine with valves. By presenting simple yet effective numerical models, the authors show how this new approach, which combines existing internal combustion technology with a lubrication system, is able to offer an economic solution to the problem of mechanical energy generation in piston engines. Their results also show that a stable heat generation process can be guaranteed outside of the engine. The book offers a detailed report on physical and numerical models of 4-stroke and 2-stroke versions of the EHVE together with different models of heat exchange, valves and results of their simulations. It also delivers the test results of an engine prototype run in laboratory conditions. By presenting a novel theoretical framework and providing readers with extensive knowledge of both the advantages and challenges of the method, this book is expected to inspire academic re...

  1. Distributed simulation a model driven engineering approach

    CERN Document Server

    Topçu, Okan; Oğuztüzün, Halit; Yilmaz, Levent

    2016-01-01

    Backed by substantive case studies, the novel approach to software engineering for distributed simulation outlined in this text demonstrates the potent synergies between model-driven techniques, simulation, intelligent agents, and computer systems development.

  2. Towards a Resource Reservation Approach for an Opportunistic Computing Environment

    International Nuclear Information System (INIS)

    Gomes, Eliza; Dantas, M A R

    2014-01-01

    Advanced reservation has been used in grid environments to provide quality of service (QoS) and to guarantee resources available at the execution time. However, in grid subtypes, such as opportunistic grid computing, it is a challenge provides QoS and guarantee of availability resources. In this article, we propose a new advanced reservation approach which offers to a user the possibility to select resources in advance for a future utilization. Therefore, the main goal of this proposal is to offer a best effort feature to a user from an opportunistic configuration. In these types of environments, it is not possible to provide QoS, because, usually, there are no guarantees of resources availability and, consequently, the execution of users applications. In addition, this research work provides a way to organize executions, what it can improve the scheduling and system operations. Experimental results, carried out through a case study, shown the efficiency and relevance of our proposal

  3. Thought-evoking approaches in engineering problems

    CERN Document Server

    2014-01-01

    In creating the value-added product in not distant future, it is necessary and inevitable to establish a holistic and though-evoking approach to the engineering problem, which should be at least associated with the inter-disciplinary knowledge and thought processes across the whole engineering spheres. It is furthermore desirable to integrate it with trans-disciplinary aspects ranging from manufacturing culture, through liberal-arts engineering, and industrial sociology.   The thought-evoking approach can be exemplified and typified by representative engineering problems: unveiling essential features in ‘Tangential Force Ratio and Interface Pressure’, prototype development for ‘Bio-mimetic Needle’ and application of ‘Water-jet Machining to Artificial Hip Joint’, product innovation in ‘Heat Sink for Computer’, application of ‘Graph Theory’ to similarity evaluation of production systems, leverage among reciprocity attributes in ‘Industrial and Engineering Designs for Machine Enclosure’,...

  4. Optimal Approaches for Measuring Tongue-Pressure Functional Reserve

    Directory of Open Access Journals (Sweden)

    Catriona M. Steele

    2013-01-01

    Full Text Available Tongue-palate pressure is a parameter of considerable interest in the field of dysphagia. Maximum isometric tongue-palate pressures (MIPs decline in healthy aging and in dysphagia. Functional reserve (FR is the difference between MIPs and swallowing pressures. Reduced FR is thought to constitute a risk for developing functional swallowing impairments. We compare different approaches for calculating FR and recommend an optimal approach. Tongue-palate pressure data were collected from 78 healthy adults (4060 during anterior and posterior MIPs, regular (RESS and effortful (ESS saliva swallows, and water swallows (4 repetitions per task. Six different measures of reserve were calculated using maximum anterior MIPs or ESS pressures at the top, and mean or maximum RESS or water swallow pressures at the bottom of the range. Correlations with age and MIPs were explored to confirm suitability for measuring FR. The impact of normalization to maximum MIP range was explored. We conclude that an optimal measure of FR involves the comparison of maximum MIP with mean saliva swallowing pressures. This parameter declines with age, but when normalized to an individual’s MIP range, the relationship is no longer evident. This suggests that FR does not necessarily decline in healthy aging.

  5. Engineering design: A cognitive process approach

    Science.gov (United States)

    Strimel, Greg Joseph

    research objectives of this study. Two independent coders then coded the video/audio recordings and the additional design data using Halfin's (1973) 17 mental processes for technological problem-solving. The results of this study indicated that the participants employed a wide array of mental processes when solving engineering design challenges. However, the findings provide a general analysis of the number of times participants employed each mental process, as well as the amount of time consumed employing the various mental processes through the different stages of the engineering design process. The results indicated many similarities between the students solving the problem, which may highlight voids in current technology and engineering education curricula. Additionally, the findings showed differences between the processes employed by participants that created the most successful solutions and the participants who developed the least effective solutions. Upon comparing and contrasting these processes, recommendations for instructional strategies to enhance a student's capability for solving engineering design problems were developed. The results also indicated that students, when left without teacher intervention, use a simplified and more natural process to solve design challenges than the 12-step engineering design process reported in much of the literature. Lastly, these data indicated that students followed two different approaches to solving the design problem. Some students employed a sequential and logical approach, while others employed a nebulous, solution centered trial-and-error approach to solving the problem. In this study the participants who were more sequential had better performing solutions. Examining these two approaches and the student cognition data enabled the researcher to generate a conceptual engineering design model for the improved teaching and development of engineering design problem solving.

  6. Systems engineering approach to preconceptual design

    International Nuclear Information System (INIS)

    1981-01-01

    Steps in the typical pre-conceptual engineering study are: problem identification, identify alternatives, evaluate alternatives, and recommend solution. Three examples of the use of pre-conceptual approach to save money are given; they include the water supply for fire protection in the 200-West Area of Hanford, emergency power for the Purex plant, and new filter for the Purex plant canyon exhaust

  7. Perspectives for Cell-homing Approaches to Engineer Dental Pulp.

    Science.gov (United States)

    Galler, Kerstin M; Widbiller, Matthias

    2017-09-01

    Sufficient proof is available today to demonstrate that dental pulp tissue engineering is possible. The body of evidence was generated mainly on cell transplantation; however, because of several severe problems afflicted with this approach, it might not be feasible for a clinical setting in the near future. More recently, cell homing has been proposed as a viable alternative. We suggest a modification of the tissue engineering paradigm, where resident cells are attracted by endogenous, dentin-derived growth factors that further induce cell proliferation and differentiation and a bioactive scaffold material laden with these growth factors that serves as a template for tissue formation. This article highlights the latest developments regarding scaffold materials, stem cells, and dentin-derived growth factors specifically for a cell-homing approach to engineer dental pulp and summarizes new ideas. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  8. Combining engineering and data-driven approaches

    DEFF Research Database (Denmark)

    Fischer, Katharina; De Sanctis, Gianluca; Kohler, Jochen

    2015-01-01

    assumptions that may result in a biased risk assessment. In two related papers we show how engineering and data-driven modelling can be combined by developing generic risk models that are calibrated to statistical data on observed fire events. The focus of the present paper is on the calibration procedure......Two general approaches may be followed for the development of a fire risk model: statistical models based on observed fire losses can support simple cost-benefit studies but are usually not detailed enough for engineering decision-making. Engineering models, on the other hand, require many....... A framework is developed that is able to deal with data collection in non-homogeneous portfolios of buildings. Also incomplete data sets containing only little information on each fire event can be used for model calibration. To illustrate the capabilities of the proposed framework, it is applied...

  9. An engineering design approach to systems biology.

    Science.gov (United States)

    Janes, Kevin A; Chandran, Preethi L; Ford, Roseanne M; Lazzara, Matthew J; Papin, Jason A; Peirce, Shayn M; Saucerman, Jeffrey J; Lauffenburger, Douglas A

    2017-07-17

    Measuring and modeling the integrated behavior of biomolecular-cellular networks is central to systems biology. Over several decades, systems biology has been shaped by quantitative biologists, physicists, mathematicians, and engineers in different ways. However, the basic and applied versions of systems biology are not typically distinguished, which blurs the separate aspirations of the field and its potential for real-world impact. Here, we articulate an engineering approach to systems biology, which applies educational philosophy, engineering design, and predictive models to solve contemporary problems in an age of biomedical Big Data. A concerted effort to train systems bioengineers will provide a versatile workforce capable of tackling the diverse challenges faced by the biotechnological and pharmaceutical sectors in a modern, information-dense economy.

  10. Engineering electrical properties of graphene: chemical approaches

    International Nuclear Information System (INIS)

    Kim, Yong-Jin; Kim, Yuna; Hong, Byung Hee; Novoselov, Konstantin

    2015-01-01

    To ensure the high performance of graphene-based devices, it is necessary to engineer the electrical properties of graphene with enhanced conductivity, controlled work function, opened or closed bandgaps, etc. This can be performed by various non-covalent chemical approaches, including molecular adsorption, substrate-induced doping, polymerization on graphene, deposition of metallic thin films or nanoparticles, etc. In addition, covalent approaches such as the substitution of carbon atoms with boron or nitrogen and the functionalization with hydrogen or fluorine are useful to tune the bandgaps more efficiently, with better uniformity and stability. In this review, representative examples of chemically engineered graphene and its device applications will be reviewed, and remaining challenges will be discussed. (topical review)

  11. Enterprise architecture approach to mining companies engineering

    Directory of Open Access Journals (Sweden)

    Ilin’ Igor

    2017-01-01

    Full Text Available As Russian economy is still largely oriented on commodities production, there are a lot of cities where mining and commodity-oriented enterprises are the backbone of city economy. The mentioned enterprises mostly define the life quality of citizens in such cities, thus there are high requirements for engineering of city-forming enterprises. The paper describes the enterprise architecture approach for management system engineering of the mining enterprises. The paper contains the model of the mining enterprise architecture, the approach to the development and implementation of an integrated management system based on the concept of enterprise architecture and the structure of information systems and information technology infrastructure of the mining enterprise.

  12. Higher Education, Reservation and Scheduled Castes: Exploring Institutional Habitus of Professional Engineering Colleges in Kerala

    Science.gov (United States)

    Malish, C. M.; Ilavarasan, P. V.

    2016-01-01

    This paper seeks to unravel the institutional context of the educational experience of scheduled caste engineering students in Kerala, a federal state in India. Though much has been debated about equity of access in the domain of reservation policies in higher education while studying the caste question and educational equity, process and outcome…

  13. Strategic quality: a software engineering approach

    OpenAIRE

    2009-01-01

    M.Ing. Software engineering organizations face a struggle for daily survival in an extremely volatile climate. Numerous times it has been shown that the quality of a service or product could make the difference between an organization existing or closing down. The way in which quality is approached in any organization is part of a strategy; unbeknown to the managers and employees in many instances. Even though there are numerous books, articles, internet sites and other sources devoted to ...

  14. A 21st century approach to engineering mechanics education

    NARCIS (Netherlands)

    Mark Smit; Stefan Persaud

    2017-01-01

    In product design engineering education, classes in engineering mechanics are often difficult, unrewarding and unsatisfying for both students and lecturers. Within the Product Design Engineering program at Rotterdam University of Applied Science, a new approach has been developed and tested,

  15. Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches.

    Science.gov (United States)

    Jang, Yu-Sin; Park, Jong Myoung; Choi, Sol; Choi, Yong Jun; Seung, Do Young; Cho, Jung Hee; Lee, Sang Yup

    2012-01-01

    The increasing oil price and environmental concerns caused by the use of fossil fuel have renewed our interest in utilizing biomass as a sustainable resource for the production of biofuel. It is however essential to develop high performance microbes that are capable of producing biofuels with very high efficiency in order to compete with the fossil fuel. Recently, the strategies for developing microbial strains by systems metabolic engineering, which can be considered as metabolic engineering integrated with systems biology and synthetic biology, have been developed. Systems metabolic engineering allows successful development of microbes that are capable of producing several different biofuels including bioethanol, biobutanol, alkane, and biodiesel, and even hydrogen. In this review, the approaches employed to develop efficient biofuel producers by metabolic engineering and systems metabolic engineering approaches are reviewed with relevant example cases. It is expected that systems metabolic engineering will be employed as an essential strategy for the development of microbial strains for industrial applications. Copyright © 2011 Elsevier Inc. All rights reserved.

  16. Unit commitment with probabilistic reserve: An IPSO approach

    International Nuclear Information System (INIS)

    Lee, Tsung-Ying; Chen, Chun-Lung

    2007-01-01

    This paper presents a new algorithm for solution of the nonlinear optimal scheduling problem. This algorithm is named the iteration particle swarm optimization (IPSO). A new index, called iteration best, is incorporated into particle swarm optimization (PSO) to improve the solution quality and computation efficiency. IPSO is applied to solve the unit commitment with probabilistic reserve problem of a power system. The outage cost as well as fuel cost of thermal units was considered in the unit commitment program to evaluate the level of spinning reserve. The optimal scheduling of on line generation units was reached while minimizing the sum of fuel cost and outage cost. A 48 unit power system was used as a numerical example to test the new algorithm. The optimal scheduling of on line generation units could be reached in the testing results while satisfying the requirement of the objective function

  17. A POGIL approach to teaching engineering hydrology

    Science.gov (United States)

    Rutten, M.

    2012-12-01

    This paper presents a case study of the author's experience using Problem Guided Inquiry Learning (POGIL) in an engineering hydrology course. This course is part of an interdisciplinary Water Management program at Bachelor level in the Netherlands. The aims of this approach were to promote constructivism of knowledge, activate critical thinking and reduce math anxiety. POGIL was developed for chemistry education in the United States. To the authors knowledge this is the first application of this approach in Europe. A first trial was done in 2010-2011 and a second trial in 2011-2012 and 55 students participated. The problems that motivated the novel approach, general information on POGIL, its implementation in the course are discussed and the results so far are evaluated.

  18. Document Clustering Approach for Meta Search Engine

    Science.gov (United States)

    Kumar, Naresh, Dr.

    2017-08-01

    The size of WWW is growing exponentially with ever change in technology. This results in huge amount of information with long list of URLs. Manually it is not possible to visit each page individually. So, if the page ranking algorithms are used properly then user search space can be restricted up to some pages of searched results. But available literatures show that no single search system can provide qualitative results from all the domains. This paper provides solution to this problem by introducing a new meta search engine that determine the relevancy of query corresponding to web page and cluster the results accordingly. The proposed approach reduces the user efforts, improves the quality of results and performance of the meta search engine.

  19. The engineering approach to winter sports

    CERN Document Server

    Cheli, Federico; Maldifassi, Stefano; Melzi, Stefano; Sabbioni, Edoardo

    2016-01-01

    The Engineering Approach to Winter Sports presents the state-of-the-art research in the field of winter sports in a harmonized and comprehensive way for a diverse audience of engineers, equipment and facilities designers, and materials scientists. The book examines the physics and chemistry of snow and ice with particular focus on the interaction (friction) between sports equipment and snow/ice, how it is influenced by environmental factors, such as temperature and pressure, as well as by contaminants and how it can be modified through the use of ski waxes or the microtextures of blades or ski soles. The authors also cover, in turn, the different disciplines in winter sports:  skiing (both alpine and cross country), skating and jumping, bob sledding and skeleton, hockey and curling, with attention given to both equipment design and on the simulation of gesture and  track optimization.

  20. Artificial intelligence approaches to software engineering

    Science.gov (United States)

    Johannes, James D.; Macdonald, James R.

    1988-01-01

    Artificial intelligence approaches to software engineering are examined. The software development life cycle is a sequence of not so well-defined phases. Improved techniques for developing systems have been formulated over the past 15 years, but pressure continues to attempt to reduce current costs. Software development technology seems to be standing still. The primary objective of the knowledge-based approach to software development presented in this paper is to avoid problem areas that lead to schedule slippages, cost overruns, or software products that fall short of their desired goals. Identifying and resolving software problems early, often in the phase in which they first occur, has been shown to contribute significantly to reducing risks in software development. Software development is not a mechanical process but a basic human activity. It requires clear thinking, work, and rework to be successful. The artificial intelligence approaches to software engineering presented support the software development life cycle through the use of software development techniques and methodologies in terms of changing current practices and methods. These should be replaced by better techniques that that improve the process of of software development and the quality of the resulting products. The software development process can be structured into well-defined steps, of which the interfaces are standardized, supported and checked by automated procedures that provide error detection, production of the documentation and ultimately support the actual design of complex programs.

  1. System engineering approach to GPM retrieval algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Rose, C. R. (Chris R.); Chandrasekar, V.

    2004-01-01

    System engineering principles and methods are very useful in large-scale complex systems for developing the engineering requirements from end-user needs. Integrating research into system engineering is a challenging task. The proposed Global Precipitation Mission (GPM) satellite will use a dual-wavelength precipitation radar to measure and map global precipitation with unprecedented accuracy, resolution and areal coverage. The satellite vehicle, precipitation radars, retrieval algorithms, and ground validation (GV) functions are all critical subsystems of the overall GPM system and each contributes to the success of the mission. Errors in the radar measurements and models can adversely affect the retrieved output values. Ground validation (GV) systems are intended to provide timely feedback to the satellite and retrieval algorithms based on measured data. These GV sites will consist of radars and DSD measurement systems and also have intrinsic constraints. One of the retrieval algorithms being studied for use with GPM is the dual-wavelength DSD algorithm that does not use the surface reference technique (SRT). The underlying microphysics of precipitation structures and drop-size distributions (DSDs) dictate the types of models and retrieval algorithms that can be used to estimate precipitation. Many types of dual-wavelength algorithms have been studied. Meneghini (2002) analyzed the performance of single-pass dual-wavelength surface-reference-technique (SRT) based algorithms. Mardiana (2003) demonstrated that a dual-wavelength retrieval algorithm could be successfully used without the use of the SRT. It uses an iterative approach based on measured reflectivities at both wavelengths and complex microphysical models to estimate both No and Do at each range bin. More recently, Liao (2004) proposed a solution to the Do ambiguity problem in rain within the dual-wavelength algorithm and showed a possible melting layer model based on stratified spheres. With the No and Do

  2. System-Level Value of a Gas Engine Power Plant in Electricity and Reserve Production

    Directory of Open Access Journals (Sweden)

    Antti Alahäivälä

    2017-07-01

    Full Text Available Power systems require a certain amount of flexibility to meet varying demand and to be able to cope with unexpected events, and this requirement is expected to increase with the emergence of variable power generation. In this paper, we focus on gas engine power plant technology and the beneficial influence its flexible operation can have on a power system. The study introduces the concept of a combined-cycle gas engine power plant (CCGE, which comprises a combination of several gas-fired combustion engines and a steam turbine. The operation of CCGE is then comprehensively analyzed in electricity and reserve production in the South African power system and compared with combined-cycle gas turbine (CCGT technology. Even though CCGE is a form of technology that has already been commercialized, it is rarely considered as a source of flexibility in the academic research. That is the notion providing the motivation for this study. Our core contribution is to show that the flexibility of CCGE can be valuable in power systems. The methodology is based on the unit-level model of the studied system and the solving of a day-ahead unit commitment problem for each day of the simulated 11-year period. The simulation studies reveal how a CCGE is able to offer system flexibility to follow hourly load variations and capacity to provide reserve power effectively.

  3. Software quality engineering a practitioner's approach

    CERN Document Server

    Suryn, Witold

    2014-01-01

    Software quality stems from two distinctive, but associated, topics in software engineering: software functional quality and software structural quality. Software Quality Engineering studies the tenets of both of these notions, which focus on the efficiency and value of a design, respectively. The text addresses engineering quality on both the application and system levels with attention to Information Systems and Embedded Systems as well as recent developments. Targeted at graduate engineering students and software quality specialists, the book analyzes the relationship between functionality

  4. Engineering honours program : A different approach

    NARCIS (Netherlands)

    Ir Antoine waal; Ir. Peter van Kollenburg

    2011-01-01

    In September 2009 the department of Engineering of Fontys University of Applied Sciences in the Netherlands has started a pilot honours program for excellent engineering students called PRogram OUstanding Development (PROUD). Aim of this program is to give those engineering students, who have the

  5. Hydrogel based approaches for cardiac tissue engineering.

    Science.gov (United States)

    Saludas, Laura; Pascual-Gil, Simon; Prósper, Felipe; Garbayo, Elisa; Blanco-Prieto, María

    2017-05-25

    Heart failure still represents the leading cause of death worldwide. Novel strategies using stem cells and growth factors have been investigated for effective cardiac tissue regeneration and heart function recovery. However, some major challenges limit their translation to the clinic. Recently, biomaterials have emerged as a promising approach to improve delivery and viability of therapeutic cells and proteins for the regeneration of the damaged heart. In particular, hydrogels are considered one of the most promising vehicles. They can be administered through minimally invasive techniques while maintaining all the desirable characteristics of drug delivery systems. This review discusses recent advances made in the field of hydrogels for cardiac tissue regeneration in detail, focusing on the type of hydrogel (conventional, injectable, smart or nano- and micro-gel), the biomaterials used for its manufacture (natural, synthetic or hybrid) and the therapeutic agent encapsulated (stem cells or proteins). We expect that these novel hydrogel-based approaches will open up new possibilities in drug delivery and cell therapies. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Engineering Sustainability: A Technical Approach to Sustainability

    OpenAIRE

    Rosen, Marc A.

    2012-01-01

    Sustainability is a critically important goal for human activity and development. Sustainability in the area of engineering is of great importance to any plans for overall sustainability given 1) the pervasiveness of engineering activities in societies, 2) their importance in economic development and living standards, and 3) the significant impacts that engineering processes and systems have had, and continue to have, on the environment. Many factors that need to be considered and appropriate...

  7. A multispectral scanner survey of the Idaho National Engineering Laboratory and the Hanford Reservation

    International Nuclear Information System (INIS)

    Brewster, S.B. Jr.; Howard, M.E.; Shines, J.E.

    1994-09-01

    An airborne multispectral scanner survey of selected sites on the Idaho National Engineering Laboratory and the Hanford Reservation was performed in mid-November 1993. Aerial multispectral scanner and photography data were acquired coincidentally with the Big O experiment at both locations. To illustrate two potential applications, the multispectral scanner data were digitally enhanced to facilitate the detection of soil disturbance and evidence of surface water transport. The main conclusion of this study was that multispectral data acquired under these conditions can be useful for soil disturbance detection. The imagery did not prove as useful, however, for direct indications of surface water transport. It was possible to infer some water transport patterns from dry water beds, but only if surface indications were present

  8. An alternative Approach to Power Engineering

    DEFF Research Database (Denmark)

    Pedersen, Knud Ole Helgesen; Havemann (retired June, 2000), Henrik

    2000-01-01

    In a drive to attract more students, three new courses have been introduced at the Department of Electric Power Engineering of the Technical University of Denmark. Among many students, power engineering has a reputation of being old-fashioned and static, whereas information technology is regarded...... as young and dynamic. Consequently, the new courses apply IT as a gateway to power engineering. The courses present the students with: (1) a meaningful, easy understandable power engineering problem; (2) a realistic set-up in the laboratory; and (3) a microprocessor system used as a tool to solve...... the problem. The students work mainly with programming but as the course develops they gain preliminary insight into the field of power engineering and experience that it is a broad field exploiting various advanced disciplines. In addition, course timing is highly important. Students must be confronted...

  9. Greenhouse engineering: New technologies and approaches

    NARCIS (Netherlands)

    Montero, J.I.; Henten, van E.J.; Son, J.E.; Castilla, N.

    2011-01-01

    Firstly, this article discusses the greenhouse engineering situation in three geographic areas which are relevant in the field of protected cultivation: Northern Asia, The Netherlands and the Mediterranean. For each area, the prevailing greenhouse type and equipment is briefly described. Secondly,

  10. Biomedical Engineering Education: A Conservative Approach

    Science.gov (United States)

    Niemi, Eugene E., Jr.

    1973-01-01

    Describes the demand for graduates from biomedical engineering programs as being not yet fully able to absorb the supply. Suggests small schools interested in entering the field consider offering their programs at the undergraduate level via a minor or an option. Examples of such options and student projects are included. (CC)

  11. Recent Approaches in Tooth Engineering Research

    Czech Academy of Sciences Publication Activity Database

    Švandová, Eva; Veselá, Barbora; Křivánek, J.; Hampl, A.; Matalová, Eva

    2014-01-01

    Roč. 60, Suppl 1 (2014), s. 21-29 ISSN 0015-5500 R&D Projects: GA ČR GAP304/11/1418; GA MZd(CZ) NT11420 Institutional support: RVO:67985904 Keywords : engineering * tooth * stem cells * culture techniques Subject RIV: EA - Cell Biology Impact factor: 1.000, year: 2014

  12. Design Approaches to Myocardial and Vascular Tissue Engineering.

    Science.gov (United States)

    Akintewe, Olukemi O; Roberts, Erin G; Rim, Nae-Gyune; Ferguson, Michael A H; Wong, Joyce Y

    2017-06-21

    Engineered tissues represent an increasingly promising therapeutic approach for correcting structural defects and promoting tissue regeneration in cardiovascular diseases. One of the challenges associated with this approach has been the necessity for the replacement tissue to promote sufficient vascularization to maintain functionality after implantation. This review highlights a number of promising prevascularization design approaches for introducing vasculature into engineered tissues. Although we focus on encouraging blood vessel formation within myocardial implants, we also discuss techniques developed for other tissues that could eventually become relevant to engineered cardiac tissues. Because the ultimate solution to engineered tissue vascularization will require collaboration between wide-ranging disciplines such as developmental biology, tissue engineering, and computational modeling, we explore contributions from each field.

  13. Helicopter Gas Turbine Engine Performance Analysis : A Multivariable Approach

    NARCIS (Netherlands)

    Arush, Ilan; Pavel, M.D.

    2017-01-01

    Helicopter performance relies heavily on the available output power of the engine(s) installed. A simplistic single-variable analysis approach is often used within the flight-testing community to reduce raw flight-test data in order to predict the available output power under different atmospheric

  14. The JPL Cost Risk Analysis Approach that Incorporates Engineering Realism

    Science.gov (United States)

    Harmon, Corey C.; Warfield, Keith R.; Rosenberg, Leigh S.

    2006-01-01

    This paper discusses the JPL Cost Engineering Group (CEG) cost risk analysis approach that accounts for all three types of cost risk. It will also describe the evaluation of historical cost data upon which this method is based. This investigation is essential in developing a method that is rooted in engineering realism and produces credible, dependable results to aid decision makers.

  15. Metabolic engineering approaches for production of biochemicals in food and medicinal plants.

    Science.gov (United States)

    Wilson, Sarah A; Roberts, Susan C

    2014-04-01

    Historically, plants are a vital source of nutrients and pharmaceuticals. Recent advances in metabolic engineering have made it possible to not only increase the concentration of desired compounds, but also introduce novel biosynthetic pathways to a variety of species, allowing for enhanced nutritional or commercial value. To improve metabolic engineering capabilities, new transformation techniques have been developed to allow for gene specific silencing strategies or stacking of multiple genes within the same region of the chromosome. The 'omics' era has provided a new resource for elucidation of uncharacterized biosynthetic pathways, enabling novel metabolic engineering approaches. These resources are now allowing for advanced metabolic engineering of plant production systems, as well as the synthesis of increasingly complex products in engineered microbial hosts. The status of current metabolic engineering efforts is highlighted for the in vitro production of paclitaxel and the in vivo production of β-carotene in Golden Rice and other food crops. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Agile Service Development: A Rule-Based Method Engineering Approach

    NARCIS (Netherlands)

    dr. Martijn Zoet; Stijn Hoppenbrouwers; Inge van de Weerd; Johan Versendaal

    2011-01-01

    Agile software development has evolved into an increasingly mature software development approach and has been applied successfully in many software vendors’ development departments. In this position paper, we address the broader agile service development. Based on method engineering principles we

  17. System engineering approach to planning anticancer therapies

    CERN Document Server

    Świerniak, Andrzej; Smieja, Jaroslaw; Puszynski, Krzysztof; Psiuk-Maksymowicz, Krzysztof

    2016-01-01

    This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book be...

  18. Enterprise Engineering Method supporting Six Sigma Approach

    OpenAIRE

    Jochem, Roland

    2007-01-01

    Enterprise Modeling (EM) is currently in operation either as a technique to represent and understand the structure and behavior of the enterprise, or as a technique to analyze business processes, and in many cases as support technique for business process reengineering. However, EM architectures and methodes for Enterprise Engineering can also used to support new management techniques like SIX SIGMA, because these new techniques need a clear, transparent and integrated definition and descript...

  19. Radio systems engineering a tutorial approach

    CERN Document Server

    Santos, Héctor J De Los; Ponte, Juan

    2015-01-01

    This book is intended for readers who already have knowledge of devices and circuits for radio-frequency (RF) and microwave communication and are ready to study the systems engineering-level aspects of modern radio communications systems. The authors provide a general overview of radio systems with their components, focusing on the analog parts of the system and their non-idealities. Based on the physical functionality of the various building blocks of a modern radio system, block parameters are derived, which allows the examination of their influence on the overall system performance. The dis

  20. An algebraic approach to modeling in software engineering

    International Nuclear Information System (INIS)

    Loegel, C.J.; Ravishankar, C.V.

    1993-09-01

    Our work couples the formalism of universal algebras with the engineering techniques of mathematical modeling to develop a new approach to the software engineering process. Our purpose in using this combination is twofold. First, abstract data types and their specification using universal algebras can be considered a common point between the practical requirements of software engineering and the formal specification of software systems. Second, mathematical modeling principles provide us with a means for effectively analyzing real-world systems. We first use modeling techniques to analyze a system and then represent the analysis using universal algebras. The rest of the software engineering process exploits properties of universal algebras that preserve the structure of our original model. This paper describes our software engineering process and our experience using it on both research and commercial systems. We need a new approach because current software engineering practices often deliver software that is difficult to develop and maintain. Formal software engineering approaches use universal algebras to describe ''computer science'' objects like abstract data types, but in practice software errors are often caused because ''real-world'' objects are improperly modeled. There is a large semantic gap between the customer's objects and abstract data types. In contrast, mathematical modeling uses engineering techniques to construct valid models for real-world systems, but these models are often implemented in an ad hoc manner. A combination of the best features of both approaches would enable software engineering to formally specify and develop software systems that better model real systems. Software engineering, like mathematical modeling, should concern itself first and foremost with understanding a real system and its behavior under given circumstances, and then with expressing this knowledge in an executable form

  1. Approaches to identifying reservoir heterogeneity and reserve growth opportunities from subsurface data: The Oficina Formation, Budare field, Venezuela

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, D.S.; Raeuchle, S.K.; Holtz, M.H. [Bureau of Economic Geology, Austin, TX (United States)] [and others

    1997-08-01

    We applied an integrated geologic, geophysical, and engineering approach devised to identify heterogeneities in the subsurface that might lead to reserve growth opportunities in our analysis of the Oficina Formation at Budare field, Venezuela. The approach involves 4 key steps: (1) Determine geologic reservoir architecture; (2) Investigate trends in reservoir fluid flow; (3) Integrate fluid flow trends with reservoir architecture; and (4) Estimate original oil-in-place, residual oil saturation, and remaining mobile oil, to identify opportunities for reserve growth. There are three main oil-producing reservoirs in the Oficina Formation that were deposited in a bed-load fluvial system, an incised valley-fill, and a barrier-strandplain system. Reservoir continuity is complex because, in addition to lateral facies variability, the major Oficina depositional systems were internally subdivided by high-frequency stratigraphic surfaces. These surfaces define times of intermittent lacustrine and marine flooding events that punctuated the fluvial and marginal marine sedimentation, respectively. Syn and post depositional faulting further disrupted reservoir continuity. Trends in fluid flow established from initial fluid levels, response to recompletion workovers, and pressure depletion data demonstrated barriers to lateral and vertical fluid flow caused by a combination of reservoir facies pinchout, flooding shale markers, and the faults. Considerable reserve growth potential exists at Budare field because the reservoir units are highly compartment by the depositional heterogeneity and structural complexity. Numerous reserve growth opportunities were identified in attics updip of existing production, in untapped or incompletely drained compartments, and in field extensions.

  2. A civil engineering approach to ideal MHD

    International Nuclear Information System (INIS)

    Jensen, V.O.

    1992-01-01

    It is well known that a magnetic field can be conceived as a medium where an isotropic compressive stress, B 2 /2μ 0 , is superimposed on a tensile stress, B 2 /μ 0 , parallel to the lines of force. When a stationary ideal MHD plasma is present in the magnetic field, the particle pressure adds to the magnetic stresses to form a combined stress tensor. Calculations of plasma equilibria based on this concept are very similar to calculations in civil engineering of static structures based on compressive, tensile, and shear stresses. Therefore the very simple physical pictures known from civil engineering when used in plasma physics provide simple physical understanding and facilitate the physical interpretation of the results. In an earlier paper the concept was used to derive and discuss the equilibrium equations for θ-, Z-, and screw pinches and the Grad-Shafranov shift in a tokamak plasma with circular cross sections of the flux surfaces. Here the concept is used to discuss the virial theorem and to obtain a simple physical interpretation of this theorem. We also reconsider the Grad-Shafranov shift in a tokamak plasma and show that a situation where all flux surfaces have circular cross sections cannot be an exact solution to the ideal MHD equations. (author) 3 refs., 3 figs

  3. Untangling natural seascape variation from marine reserve effects using a landscape approach.

    Directory of Open Access Journals (Sweden)

    Brittany E Huntington

    Full Text Available Distinguishing management effects from the inherent variability in a system is a key consideration in assessing reserve efficacy. Here, we demonstrate how seascape heterogeneity, defined as the spatial configuration and composition of coral reef habitats, can mask our ability to discern reserve effects. We then test the application of a landscape approach, utilizing advances in benthic habitat mapping and GIS techniques, to quantify this heterogeneity and alleviate the confounding influence during reserve assessment. Seascape metrics were quantified at multiple spatial scales using a combination of spatial image analysis and in situ surveys at 87 patch reef sites in Glover's Reef Lagoon, Belize, within and outside a marine reserve enforced since 1998. Patch reef sites were then clustered into classes sharing similar seascape attributes using metrics that correlated significantly to observed variations in both fish and coral communities. When the efficacy of the marine reserve was assessed without including landscape attributes, no reserve effects were detected in the diversity and abundance of fish and coral communities, despite 10 years of management protection. However, grouping sites based on landscape attributes revealed significant reserve effects between site classes. Fish had higher total biomass (1.5x and commercially important biomass (1.75x inside the reserve and coral cover was 1.8 times greater inside the reserve, though direction and degree of response varied by seascape class. Our findings show that the application of a landscape classification approach vastly improves our ability to evaluate the efficacy of marine reserves by controlling for confounding effects of seascape heterogeneity and suggests that landscape heterogeneity should be considered in future reserve design.

  4. A Systems Engineering Approach to Architecture Development

    Science.gov (United States)

    Di Pietro, David A.

    2014-01-01

    Architecture development is conducted prior to system concept design when there is a need to determine the best-value mix of systems that works collectively in specific scenarios and time frames to accomplish a set of mission area objectives. While multiple architecture frameworks exist, they often require use of unique taxonomies and data structures. In contrast, this presentation characterizes architecture development using terminology widely understood within the systems engineering community. Using a notional civil space architecture example, it employs a multi-tier framework to describe the enterprise level architecture and illustrates how results of lower tier, mission area architectures integrate into the enterprise architecture. It also presents practices for conducting effective mission area architecture studies, including establishing the trade space, developing functions and metrics, evaluating the ability of potential design solutions to meet the required functions, and expediting study execution through the use of iterative design cycles.

  5. A Systems Engineering Approach to Architecture Development

    Science.gov (United States)

    Di Pietro, David A.

    2015-01-01

    Architecture development is often conducted prior to system concept design when there is a need to determine the best-value mix of systems that works collectively in specific scenarios and time frames to accomplish a set of mission area objectives. While multiple architecture frameworks exist, they often require use of unique taxonomies and data structures. In contrast, this paper characterizes architecture development using terminology widely understood within the systems engineering community. Using a notional civil space architecture example, it employs a multi-tier framework to describe the enterprise level architecture and illustrates how results of lower tier, mission area architectures integrate into the enterprise architecture. It also presents practices for conducting effective mission area architecture studies, including establishing the trade space, developing functions and metrics, evaluating the ability of potential design solutions to meet the required functions, and expediting study execution through the use of iterative design cycles

  6. Engine Icing Data - An Analytics Approach

    Science.gov (United States)

    Fitzgerald, Brooke A.; Flegel, Ashlie B.

    2017-01-01

    Engine icing researchers at the NASA Glenn Research Center use the Escort data acquisition system in the Propulsion Systems Laboratory (PSL) to generate and collect a tremendous amount of data every day. Currently these researchers spend countless hours processing and formatting their data, selecting important variables, and plotting relationships between variables, all by hand, generally analyzing data in a spreadsheet-style program (such as Microsoft Excel). Though spreadsheet-style analysis is familiar and intuitive to many, processing data in spreadsheets is often unreproducible and small mistakes are easily overlooked. Spreadsheet-style analysis is also time inefficient. The same formatting, processing, and plotting procedure has to be repeated for every dataset, which leads to researchers performing the same tedious data munging process over and over instead of making discoveries within their data. This paper documents a data analysis tool written in Python hosted in a Jupyter notebook that vastly simplifies the analysis process. From the file path of any folder containing time series datasets, this tool batch loads every dataset in the folder, processes the datasets in parallel, and ingests them into a widget where users can search for and interactively plot subsets of columns in a number of ways with a click of a button, easily and intuitively comparing their data and discovering interesting dynamics. Furthermore, comparing variables across data sets and integrating video data (while extremely difficult with spreadsheet-style programs) is quite simplified in this tool. This tool has also gathered interest outside the engine icing branch, and will be used by researchers across NASA Glenn Research Center. This project exemplifies the enormous benefit of automating data processing, analysis, and visualization, and will help researchers move from raw data to insight in a much smaller time frame.

  7. Physiome approach for the analysis of vascular flow reserve in the heart and brain.

    Science.gov (United States)

    Lee, Kyung Eun; Ryu, Ah-Jin; Shin, Eun-Seok; Shim, Eun Bo

    2017-06-01

    This work reviews the key aspects of coronary and neurovascular flow reserves with an emphasis on physiomic modeling characteristics by the use of a variety of numerical approaches. First, we explain the definition of fractional flow reserve (FFR) in coronary artery and introduce its clinical significance. Then, computational researches for obtaining FFR are reviewed, and their clinical outcomes are compared. In the case of cerebrovascular reserve (CVR), in spite of substantial progress in the simulation of cerebral hemodynamics, only a few computational studies exist. Thus, we discuss the limitations of CVR simulation study and suggest the challenging issue to overcome these. Also, the future direction of physiomic researches for the flow reserves in coronary arteries and cerebral arteries is described. Also, we introduce a machine learning algorithm trained by the existing physiomic simulation data of flow reserve and suggest a prospective research direction related to this.

  8. Putting engineering back into protein engineering: bioinformatic approaches to catalyst design.

    Science.gov (United States)

    Gustafsson, Claes; Govindarajan, Sridhar; Minshull, Jeremy

    2003-08-01

    Complex multivariate engineering problems are commonplace and not unique to protein engineering. Mathematical and data-mining tools developed in other fields of engineering have now been applied to analyze sequence-activity relationships of peptides and proteins and to assist in the design of proteins and peptides with specified properties. Decreasing costs of DNA sequencing in conjunction with methods to quickly synthesize statistically representative sets of proteins allow modern heuristic statistics to be applied to protein engineering. This provides an alternative approach to expensive assays or unreliable high-throughput surrogate screens.

  9. Engineering systems reliability, safety, and maintenance an integrated approach

    CERN Document Server

    Dhillon, B S

    2017-01-01

    Today, engineering systems are an important element of the world economy and each year billions of dollars are spent to develop, manufacture, operate, and maintain various types of engineering systems around the globe. Many of these systems are highly sophisticated and contain millions of parts. For example, a Boeing jumbo 747 is made up of approximately 4.5 million parts including fasteners. Needless to say, reliability, safety, and maintenance of systems such as this have become more important than ever before.  Global competition and other factors are forcing manufacturers to produce highly reliable, safe, and maintainable engineering products. Therefore, there is a definite need for the reliability, safety, and maintenance professionals to work closely during design and other phases. Engineering Systems Reliability, Safety, and Maintenance: An Integrated Approach eliminates the need to consult many different and diverse sources in the hunt for the information required to design better engineering syste...

  10. Some Theological Reservations Surrounding One Contemporary Christian Approach to Teaching and Learning

    Science.gov (United States)

    Whittle, Sean

    2014-01-01

    This article raises a number of theological reservations about one contemporary Christian approach to teaching and learning. For many years David Smith and Trevor Cooling have played a leading role in demonstrating how Christian beliefs and theological themes might be integrated into classroom practice across the curriculum. But despite the good…

  11. Optimisation of Multilayer Insulation an Engineering Approach

    CERN Document Server

    Chorowski, M; Parente, C; Riddone, G

    2001-01-01

    A mathematical model has been developed to describe the heat flux through multilayer insulation (MLI). The total heat flux between the layers is the result of three distinct heat transfer modes: radiation, residual gas conduction and solid spacer conduction. The model describes the MLI behaviour considering a layer-to-layer approach and is based on an electrical analogy, in which the three heat transfer modes are treated as parallel thermal impedances. The values of each of the transfer mode vary from layer to layer, although the total heat flux remains constant across the whole MLI blanket. The model enables the optimisation of the insulation with regard to different MLI parameters, such as residual gas pressure, number of layers and boundary temperatures. The model has been tested with experimental measurements carried out at CERN and the results revealed to be in a good agreement, especially for insulation vacuum between 10-5 Pa and 10-3 Pa.

  12. Economic-environmental energy and reserve scheduling of smart distribution systems: A multiobjective mathematical programming approach

    International Nuclear Information System (INIS)

    Zakariazadeh, Alireza; Jadid, Shahram; Siano, Pierluigi

    2014-01-01

    Highlights: • Environmental/economical scheduling of energy and reserve. • Simultaneous participation of loads in both energy and reserve scheduling. • Aggregate wind generation and demand uncertainties in a stochastic model. • Stochastic scheduling of energy and reserve in a distribution system. • Demand response providers’ participation in energy and reserve scheduling. - Abstract: In this paper a stochastic multi-objective economical/environmental operational scheduling method is proposed to schedule energy and reserve in a smart distribution system with high penetration of wind generation. The proposed multi-objective framework, based on augmented ε-constraint method, is used to minimize the total operational costs and emissions and to generate Pareto-optimal solutions for the energy and reserve scheduling problem. Moreover, fuzzy decision making process is employed to extract one of the Pareto-optimal solutions as the best compromise non-dominated solution. The wind power and demand forecast errors are considered in this approach and the reserve can be furnished by the main grid as well as distributed generators and responsive loads. The consumers participate in both energy and reserve markets using various demand response programs. In order to facilitate small and medium loads participation in demand response programs, a Demand Response Provider (DRP) aggregates offers for load reduction. In order to solve the proposed optimization model, the Benders decomposition technique is used to convert the large scale mixed integer non-linear problem into mixed-integer linear programming and non-linear programming problems. The effectiveness of the proposed scheduling approach is verified on a 41-bus distribution test system over a 24-h period

  13. Recent advances in rational approaches for enzyme engineering

    Directory of Open Access Journals (Sweden)

    Kerstin Steiner

    2012-09-01

    Full Text Available Enzymes are an attractive alternative in the asymmetric syntheses of chiral building blocks. To meet the requirements of industrial biotechnology and to introduce new functionalities, the enzymes need to be optimized by protein engineering. This article specifically reviews rational approaches for enzyme engineering and de novo enzyme design involving structure-based approaches developed in recent years for improvement of the enzymes’ performance, broadened substrate range, and creation of novel functionalities to obtain products with high added value for industrial applications.

  14. Complex approach in telecommunication engineering education: develop engineering skills by a team project

    OpenAIRE

    Scripcariu Luminița; Mătăsaru Petre-Daniel

    2017-01-01

    This paper provides an overview of the educational process of telecommunication engineering students by presenting the preparation of a team project focused on information security. Our educational approach combines basic knowledge such as mathematics with specialized engineering notions and various skills. The project theme is to design, implement and test an encryption algorithm. Students are provided with online courses, specific software programs and Internet access. They have to choose a...

  15. Systems engineering approach for future automotive microcontroller solutions; Systems-Engineering-Ansatz zur Entwicklung zukuenftiger Mikrocontroller

    Energy Technology Data Exchange (ETDEWEB)

    Hilgert, J.; Turski, K.; Vollhardt, S. [NEC Electronics Europe, Duesseldorf (Germany)

    2005-09-01

    In the future, microcontrollers used in automotive applications will have to meet escalating demands from different areas. For this reason, NEC Electronics (Europe) regards the concept of Systems Engineering as the key to handling the development of the complex system vehicle. This article describes how the Systems Engineering approach is applied to the development of new microcontrollers. The example used is the development platform for NEC's upcoming gateway product. (orig.)

  16. An Ontological-Fuzzy Approach to Advance Reservation in Multi-Cluster Grids

    International Nuclear Information System (INIS)

    Ferreira, D J; Dantas, M A R; Bauer, Michael A

    2010-01-01

    Advance reservation is an important mechanism for a successful utilization of available resources in distributed multi-cluster environments. This mechanism allows, for example, a user to provide parameters aiming to satisfy requirements related to applications' execution time and temporal dependence. This predictability can lead the system to reach higher levels of QoS. However, the support for advance reservation has been restricted due to the complexity of large scale configurations and also dynamic changes verified in these systems. In this research work it is proposed an advance reservation method, based on a ontology-fuzzy approach. It allows a user to reserve a wide variety of resources and enable large jobs to be reserved among different nodes. In addition, it dynamically verifies the possibility of reservation with the local RMS, avoiding future allocation conflicts. Experimental results of the proposal, through simulation, indicate that the proposed mechanism reached a successful level of flexibility for large jobs and more appropriated distribution of resources in a distributed multi-cluster configuration.

  17. Integrated system approach for increase of engine combined cycle efficiency

    International Nuclear Information System (INIS)

    Gewald, D.; Karellas, S.; Schuster, A.; Spliethoff, H.

    2012-01-01

    Highlights: ► A new approach for the optimization of engine combined cycle systems is presented. ► The efficiency can be increased by integrating all available waste heat sources. ► The optimization of the ICE cooling system towards higher temperatures is examined. ► Higher engine cooling water temperatures increase the combined cycle efficiency. ► The costs of electricity generation can be decreased by five integrated system. - Abstract: Internal combustion engines (ICEs) are widely used as independent power producers due to their high electrical efficiency (up to 47%), which can be further enhanced by operating them in combined cycle mode with a water/steam cycle as bottoming cycle. This study presents an integrated approach to optimize the combined cycle overall system efficiency. Therefore, not only the most favorable design of the waste heat recovery (WHR) cycle, but also the optimal configuration of the ICE cooling system have to be investigated, in order to integrate both available engine waste heat sources (exhaust gas, 300–400 °C, engine cooling water, 90 °C) into the waste heat recovery cycle. For the definition of the most favourable temperature level of the engine cooling water three variants of engine cooling systems are examined, with respect to technical limitations given by the ICE. In order to determine the types of engines for which this optimization approach is suitable, three types of engines with different characteristics (fuel, exhaust gas parameters) combined with a water/steam cycle are simulated, by using the calculation tools Excel and Ebsilon Professional. An energetic, exergetic and economic analysis is conducted. These reveal the impacts of the temperature level to the WHR system and to the design of the engine cooling system. The calculations performed, showed that up to 19% of the engine cooling water heat can be efficiently recovered compared to a portion of 6% in the standard system. The better recovery leads to a 5

  18. A Synthetic Biology Approach to Engineering Living Photovoltaics.

    Science.gov (United States)

    Schuergers, N; Werlang, C; Ajo-Franklin, C M; Boghossian, A A

    2017-05-01

    The ability to electronically interface living cells with electron accepting scaffolds is crucial for the development of next-generation biophotovoltaic technologies. Although recent studies have focused on engineering synthetic interfaces that can maximize electronic communication between the cell and scaffold, the efficiency of such devices is limited by the low conductivity of the cell membrane. This review provides a materials science perspective on applying a complementary, synthetic biology approach to engineering membrane-electrode interfaces. It focuses on the technical challenges behind the introduction of foreign extracellular electron transfer pathways in bacterial host cells and the past and future efforts to engineer photosynthetic organisms with artificial electron-export capabilities for biophotovoltaic applications. The article highlights advances in engineering protein-based, electron-exporting conduits in a model host organism, E. coli, before reviewing state-of-the-art biophotovoltaic technologies that use both unmodified and bioengineered photosynthetic bacteria with improved electron transport capabilities. A thermodynamic analysis is used to propose an energetically feasible pathway for extracellular electron transport in engineered cyanobacteria and identify metabolic bottlenecks amenable to protein engineering techniques. Based on this analysis, an engineered photosynthetic organism expressing a foreign, protein-based electron conduit yields a maximum theoretical solar conversion efficiency of 6-10% without accounting for additional bioengineering optimizations for light-harvesting.

  19. A multi-criteria decision making approach for food engineering

    OpenAIRE

    Abakarov, Alik

    2011-01-01

    The objective of this study was to propose a decision making approach and tools (software packages) to solve the multi-criteria decision making problems arising in the food engineering. The proposed decision making approach is based on a simultaneous utilization for a given set of Pareto-optimal solutions the two following decision making methods: 1) well-known Analytic Hierarchy Process method and 2) Tabular Method. The using of Tabular Method allows utilizing the AHP method in a...

  20. Rational and random approaches to adenoviral vector engineering

    NARCIS (Netherlands)

    Uil, Taco Gilles

    2011-01-01

    The overall aim of this thesis is to contribute to the engineering of more selective and effective oncolytic Adenovirus (Ad) vectors. Two general approaches are taken for this purpose: (i) genetic capsid modification to achieve Ad retargeting (Chapters 2 to 4), and (ii) directed evolution to improve

  1. Engineering Attractiveness in the European Educational Environment: Can Distance Education Approaches Make a Difference?

    Directory of Open Access Journals (Sweden)

    Konstantinos Katzis

    2018-01-01

    Full Text Available The recent phenomenon of worldwide declining enrolments in engineering-related degrees has led to the gradual decrease in the number of engineering graduates. This decrease occurs at a time of increasing demand in the labour market for highly qualified engineers, who are necessary for the implementation of fundamental societal functions. This paper initially presents a survey of practices, which are currently employed by academic institutions in Europe in order to increase the attractiveness of their engineering studies. It then provides a detailed analysis of the benefits and proliferation of distance education to increase attractiveness of engineering studies based on a set of interviews. Results of this study, highlight a lack of a distance-learning dimension in the implementation of engineering studies in the European Area and discusses in detail ways in which distance learning can be utilised in engineering studies for the benefit of increasing their attractiveness. It has also been noted that institutions employing distance learning as part of their engineering studies, see this as highly beneficial for their students but also for the academic institution itself with some reservations in terms of the pedagogical adequacy of materials and instructional approaches used in distance education courses.

  2. Cognitive and brain reserve for mind-body therapeutic approaches in multiple sclerosis: a review.

    Science.gov (United States)

    Crescentini, Cristiano; Urgesi, Cosimo; Fabbro, Franco; Eleopra, Roberto

    2014-01-01

    Cognitive impairment is one of the most disabling symptoms of multiple sclerosis (MS), affecting a large proportion of patients and having a severe impact on their quality of life. Nevertheless, there exists a large variability in the neuropsychological profiles of MS patients and some of them appear to withstand better than others the MS-related brain pathology before showing cognitive decline. In recent years, many studies have made use of concepts such as cognitive reserve and brain reserve to take account of the inter-individual discrepancy between cognitive impairment and MS pathology. Critically, these studies have left open the fundamental issue of the clinical implications of this research for the treatment of cognitive dysfunction in MS. We provide an updated and extensive overview of the studies that have explored cognitive and brain reserve in MS and discuss their implications for non-pharmacological therapeutic strategies aimed at potentiating patients' reserve. In particular, the possible utility of integrated approaches based on mind-body techniques such as mindfulness-meditation is considered. We conclude that these techniques represent challenging mental enriching activities that may help cultivating cognitive reserve and more systematic research on their efficacy to protect against cognitive degradation in MS is encouraged.

  3. Biological augmentation and tissue engineering approaches in meniscus surgery.

    Science.gov (United States)

    Moran, Cathal J; Busilacchi, Alberto; Lee, Cassandra A; Athanasiou, Kyriacos A; Verdonk, Peter C

    2015-05-01

    biochemical cues in this process, however, and it is hoped that this may lead to improvements in this strategy. There appears to be significant potential for biological augmentation and tissue engineering strategies in meniscus surgery to enhance options for repair and replacement. However, there are still relatively few clinical studies being reported in this regard. There is a strong need for improved translational activities and infrastructure to link the large amounts of in vitro and preclinical biological and tissue engineering data to clinical application. Level IV, systematic review of Level I-IV studies. Copyright © 2015 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  4. Engineering system dynamics a unified graph-centered approach

    CERN Document Server

    Brown, Forbes T

    2006-01-01

    For today's students, learning to model the dynamics of complex systems is increasingly important across nearly all engineering disciplines. First published in 2001, Forbes T. Brown's Engineering System Dynamics: A Unified Graph-Centered Approach introduced students to a unique and highly successful approach to modeling system dynamics using bond graphs. Updated with nearly one-third new material, this second edition expands this approach to an even broader range of topics. What's New in the Second Edition? In addition to new material, this edition was restructured to build students' competence in traditional linear mathematical methods before they have gone too far into the modeling that still plays a pivotal role. New topics include magnetic circuits and motors including simulation with magnetic hysteresis; extensive new material on the modeling, analysis, and simulation of distributed-parameter systems; kinetic energy in thermodynamic systems; and Lagrangian and Hamiltonian methods. MATLAB(R) figures promi...

  5. Towards Multi-Method Research Approach in Empirical Software Engineering

    Science.gov (United States)

    Mandić, Vladimir; Markkula, Jouni; Oivo, Markku

    This paper presents results of a literature analysis on Empirical Research Approaches in Software Engineering (SE). The analysis explores reasons why traditional methods, such as statistical hypothesis testing and experiment replication are weakly utilized in the field of SE. It appears that basic assumptions and preconditions of the traditional methods are contradicting the actual situation in the SE. Furthermore, we have identified main issues that should be considered by the researcher when selecting the research approach. In virtue of reasons for weak utilization of traditional methods we propose stronger use of Multi-Method approach with Pragmatism as the philosophical standpoint.

  6. Sundanese ancient manuscripts search engine using probability approach

    Science.gov (United States)

    Suryani, Mira; Hadi, Setiawan; Paulus, Erick; Nurma Yulita, Intan; Supriatna, Asep K.

    2017-10-01

    Today, Information and Communication Technology (ICT) has become a regular thing for every aspect of live include cultural and heritage aspect. Sundanese ancient manuscripts as Sundanese heritage are in damage condition and also the information that containing on it. So in order to preserve the information in Sundanese ancient manuscripts and make them easier to search, a search engine has been developed. The search engine must has good computing ability. In order to get the best computation in developed search engine, three types of probabilistic approaches: Bayesian Networks Model, Divergence from Randomness with PL2 distribution, and DFR-PL2F as derivative form DFR-PL2 have been compared in this study. The three probabilistic approaches supported by index of documents and three different weighting methods: term occurrence, term frequency, and TF-IDF. The experiment involved 12 Sundanese ancient manuscripts. From 12 manuscripts there are 474 distinct terms. The developed search engine tested by 50 random queries for three types of query. The experiment results showed that for the single query and multiple query, the best searching performance given by the combination of PL2F approach and TF-IDF weighting method. The performance has been evaluated using average time responds with value about 0.08 second and Mean Average Precision (MAP) about 0.33.

  7. Review of Requirement Engineering Approaches for Software Product Lines

    OpenAIRE

    Blanes Dominguez, David; Insfrán Pelozo, César Emilio

    2011-01-01

    The Software Product Lines (SPL) paradigm is one of the most recent topics of interest for the software engineering community. On the one hand, the Software Product Lines is based on a reuse strategy with the aim to reduce the global time-to-market of the software product, to improve the software product quality, and to reduce the cost. On the other hand, traditional Requirement Engineering approaches could not be appropriated to deal with the new challenges that arises the SPL adoption. In t...

  8. A scientific approach to writing for engineers and scientists

    CERN Document Server

    Berger, Robert E

    2014-01-01

    This book is a guide to technical writing, presented in a systematic framework that mirrors the logic associated with the scientific process itself. Other English books merely define concepts and provide rules; this one explains the reasoning behind the rules. Other writing books for scientists and engineers focus primarily on how to gather and organize materials; this one focuses primarily on how to compose a readable sentence. The approach should be satisfying not only to scientists and engineers, but also to anyone that once took a grammar course but can't remember the rules - because there was no exposure to underlying principles.

  9. The Need for Integrated Approaches in Metabolic Engineering

    Energy Technology Data Exchange (ETDEWEB)

    Lechner, Anna; Brunk, Elizabeth; Keasling, Jay D.

    2016-08-15

    This review highlights state-of-the-art procedures for heterologous small-molecule biosynthesis, the associated bottlenecks, and new strategies that have the potential to accelerate future accomplishments in metabolic engineering. We emphasize that a combination of different approaches over multiple time and size scales must b e considered for successful pathway engineering in a heterologous host. We have classified these optimization procedures based on the "system" that is being manipulated: transcriptome, translatome, proteome, or reactome. By bridging multiple disciplines, including molecular biology, biochemistry, biophysics, and computational sciences, we can create an integral framework for the discovery and implementation of novel biosynthetic production routes.

  10. Learning intervention and the approach to study of engineering undergraduates

    Science.gov (United States)

    Solomonides, Ian Paul

    The aim of the research was to: investigate the effect of a learning intervention on the Approach to Study of first year engineering degree students. The learning intervention was a local programme of learning to learn' workshops designed and facilitated by the author. The primary aim of these was to develop students' Approaches to Study. Fifty-three first year engineering undergraduates at The Nottingham Trent University participated in the workshops. Approaches to Study were quantified using data obtained from the Revised Approach to Study Inventory (RASI) which was also subjected to a validity and reliability study using local data. Quantitative outcomes were supplemented using a qualitative analysis of essays written by students during the workshops. These were analysed for detail regarding student Approach to Study. It was intended that any findings would inform the local system of Engineering Education, although more general findings also emerged, in particular in relation to the utility of the research instrument. It was concluded that the intervention did not promote the preferential Deep Approach and did not affect Approaches to Study generally as measured by the RASI. This concurred with previous attempts to change student Approaches to Study at the group level. It was also established that subsequent years of the Integrated Engineering degree course are associated with progressively deteriorating Approaches to Study. Students who were exposed to the intervention followed a similar pattern of deteriorating Approaches suggesting that the local course context and its demands had a greater influence over the Approach of students than the intervention did. It was found that academic outcomes were unrelated to the extent to which students took a Deep Approach to the local assessment demands. There appeared therefore to be a mis-match between the Approach students adopted to pass examinations and those that are required for high quality learning outcomes. It is

  11. NASA's Systems Engineering Approaches for Addressing Public Health Surveillance Requirements

    Science.gov (United States)

    Vann, Timi

    2003-01-01

    NASA's systems engineering has its heritage in space mission analysis and design, including the end-to-end approach to managing every facet of the extreme engineering required for successful space missions. NASA sensor technology, understanding of remote sensing, and knowledge of Earth system science, can be powerful new tools for improved disease surveillance and environmental public health tracking. NASA's systems engineering framework facilitates the match between facilitates the match between partner needs and decision support requirements in the areas of 1) Science/Data; 2) Technology; 3) Integration. Partnerships between NASA and other Federal agencies are diagrammed in this viewgraph presentation. NASA's role in these partnerships is to provide systemic and sustainable solutions that contribute to the measurable enhancement of a partner agency's disease surveillance efforts.

  12. Parallel science and engineering applications the charm++ approach

    CERN Document Server

    Kale, Laxmikant V

    2016-01-01

    Developed in the context of science and engineering applications, with each abstraction motivated by and further honed by specific application needs, Charm++ is a production-quality system that runs on almost all parallel computers available. Parallel Science and Engineering Applications: The Charm++ Approach surveys a diverse and scalable collection of science and engineering applications, most of which are used regularly on supercomputers by scientists to further their research. After a brief introduction to Charm++, the book presents several parallel CSE codes written in the Charm++ model, along with their underlying scientific and numerical formulations, explaining their parallelization strategies and parallel performance. These chapters demonstrate the versatility of Charm++ and its utility for a wide variety of applications, including molecular dynamics, cosmology, quantum chemistry, fracture simulations, agent-based simulations, and weather modeling. The book is intended for a wide audience of people i...

  13. Parallel science and engineering applications the Charm++ approach

    CERN Document Server

    Kale, Laxmikant V

    2016-01-01

    Developed in the context of science and engineering applications, with each abstraction motivated by and further honed by specific application needs, Charm++ is a production-quality system that runs on almost all parallel computers available. Parallel Science and Engineering Applications: The Charm++ Approach surveys a diverse and scalable collection of science and engineering applications, most of which are used regularly on supercomputers by scientists to further their research. After a brief introduction to Charm++, the book presents several parallel CSE codes written in the Charm++ model, along with their underlying scientific and numerical formulations, explaining their parallelization strategies and parallel performance. These chapters demonstrate the versatility of Charm++ and its utility for a wide variety of applications, including molecular dynamics, cosmology, quantum chemistry, fracture simulations, agent-based simulations, and weather modeling. The book is intended for a wide audience of people i...

  14. Role of reservoir engineering in the assessment of undiscovered oil and gas resources in the National Petroleum Reserve, Alaska

    Science.gov (United States)

    Verma, M.K.; Bird, K.J.

    2005-01-01

    The geology and reservoir-engineering data were integrated in the 2002 U.S. Geological Survey assessment of the National Petroleum Reserve in Alaska (NPRA). VVhereas geology defined the analog pools and fields and provided the basic information on sizes and numbers of hypothesized petroleum accumulations, reservoir engineering helped develop necessary equations and correlations, which allowed the determination of reservoir parameters for better quantification of in-place petroleum volumes and recoverable reserves. Seismic- and sequence-stratigraphic study of the NPRA resulted in identification of 24 plays. Depth ranges in these 24 plays, however, were typically greater than depth ranges of analog plays for which there were available data, necessitating the need for establishing correlations. The basic parameters required were pressure, temperature, oil and gas formation volume factors, liquid/gas ratios for the associated and nonassociated gas, and recovery factors. Finally, the re sults of U.S. Geological Survey deposit simulation were used in carrying out an economic evaluation, which has been separately published. Copyright ?? 2005. The American Association of Petroleum Geologists. All rights reserved.

  15. Enhanced crystallizability by protein engineering approaches: a general overview.

    Science.gov (United States)

    Ruggiero, Alessia; Smaldone, Giovanni; Squeglia, Flavia; Berisio, Rita

    2012-07-01

    The limiting step in macromolecular crystallography is the preparation protein crystals suitable for X-ray diffraction studies. A strong prerequisite for the success of crystallization experiments is the ability to produce monodisperse and properly folded protein samples. Since the production of most protein is usually achieved using recombinant methods, it has become possible to engineer target proteins with increased propensities to form well diffracting crystals. Recent advances in bioinformatics, which takes advantage from an enhanced information in the protein databases, are of enormous help for the design of modified proteins. Based on bioinformatics analyses, the reduction of the structural complexity of proteins or their site-specific mutagenesis has proven to have a dramatic impact on both the yield of heterologous protein expression and its crystallizability. Therefore, protein engineering represents a valid tool which supports the classical crystallization screenings with a more rational approach. This review describes key methods of protein-engineering and provides a number of examples of their successful use in crystallization. Scope of proposed topic: This Topic is focused on state-of-art protein engineering techniques to increase the propensity of proteins to form crystals with suitable X-ray diffraction properties. Protein engineering methods have proven to be of great help for the crystallization of difficult targets. We herein review molecular biology and chemical methods to help protein crystallization.

  16. Merged ontology for engineering design: Contrasting empirical and theoretical approaches to develop engineering ontologies

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Storga, M

    2009-01-01

    This paper presents a comparison of two previous and separate efforts to develop an ontology in the engineering design domain, together with an ontology proposal from which ontologies for a specific application may be derived. The research contrasts an empirical, user-centered approach to develop...... that is theoretically sound and another that is applicable, is recognized and argued. Finally, the merged ontology for engineering design is proposed as a template ontology that can be tailored by researchers and practitioners for a specific context....

  17. A Lean Approach to Scheduling Systems Engineering Resources

    Science.gov (United States)

    2013-05-01

    application in SE. We have defined a general Kanban -based Scheduling System (KSS) that we believe captures the essence of lean flow management visibility...finally delivered to the user Lean approaches strive to maximize flow through a process— often by using on-demand ( Kanban ) scheduling techniques...Technical Report,” Systems Engineering Research Center, SERC-2010-TR004, December 2009. 8. Anderson, David. (2010). Kanban : Successful Evolutionary

  18. Fast engineering optimization: A novel highly effective control parameterization approach for industrial dynamic processes.

    Science.gov (United States)

    Liu, Ping; Li, Guodong; Liu, Xinggao

    2015-09-01

    Control vector parameterization (CVP) is an important approach of the engineering optimization for the industrial dynamic processes. However, its major defect, the low optimization efficiency caused by calculating the relevant differential equations in the generated nonlinear programming (NLP) problem repeatedly, limits its wide application in the engineering optimization for the industrial dynamic processes. A novel highly effective control parameterization approach, fast-CVP, is first proposed to improve the optimization efficiency for industrial dynamic processes, where the costate gradient formulae is employed and a fast approximate scheme is presented to solve the differential equations in dynamic process simulation. Three well-known engineering optimization benchmark problems of the industrial dynamic processes are demonstrated as illustration. The research results show that the proposed fast approach achieves a fine performance that at least 90% of the computation time can be saved in contrast to the traditional CVP method, which reveals the effectiveness of the proposed fast engineering optimization approach for the industrial dynamic processes. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  19. Hydrogen Fuel Cell on a Helicopter: A System Engineering Approach

    Science.gov (United States)

    Nesheiwat, Rod

    Hydrogen fuel cells have been previously investigated as a viable replacement to traditional gas turbine auxiliary power unit onboard fixed wing commercial jets. However, so far no study has attempted to extend their applicability to rotary wing aircrafts. To aid in the advancement of such innovative technologies, a holistic technical approach is required to ensure risk reduction and cost effectiveness throughout the product lifecycle. This paper will evaluate the feasibility of replacing a gas turbine auxiliary power unit on a helicopter with a direct hydrogen, air breathing, proton exchange membrane fuel cell, all while emphasizing a system engineering approach that utilize a specialized set of tools and artifacts.

  20. Pathway and protein engineering approaches to produce novel and commodity small molecules.

    Science.gov (United States)

    Bhan, Namita; Xu, Peng; Koffas, Mattheos A G

    2013-12-01

    Nature has provided us the basis of designing the most integrated and efficacious production platforms. Cell factories via their millions of years of evolution have nearly perfected each of their production systems. We have been trying to imitate, utilize and tweak this system to our advantage by using slightly overlapping and greatly interdependent approaches such as metabolic engineering and systems biology to make nature work for us in an efficient and robust way, without producing toxic waste and/or unnecessary side products. Systems biology, metabolic engineering and 'omics' technologies have paved the way for protein and pathway engineering. To this end we will talk about the recent advances in production of novel pharmaceutical and commodity small molecules by designing novel proteins and pathways. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Broadening of nuclear engineering programs: An engineering physics approach at Rensselaer

    International Nuclear Information System (INIS)

    Malaviya, B.K.

    1990-01-01

    With the maturing of nuclear engineering as an academic discipline and the uncertainty surrounding the nuclear industry, attention is being increasingly turned to ways in which the base of traditional nuclear engineering programs in universities can be broadened to make them more attractively useful to a wider class of potential students and employers while maintaining the strengths in mainstream areas of nuclear technology. An approach that seems to provide a natural evolution combining the existing programmatic strengths, infrastructure, and resources with the trending needs of a broad segment of diversified industries is the development and initiation of an engineering physics degree program as an adjunct to an established nuclear engineering curriculum. In line with these developments, a new comprehensive academic program offering baccalaureate, master's, and doctoral degrees in engineering physics has been developed and formally instituted at Rensselaer Polytechnic Institute (RPI). It provides a valuable opportunity for students to pursue education and research that cuts across traditional disciplinary lines, leading to a wide variety of career opportunities in industry, government, national research and defense laboratories, and academia

  2. Implementing CDIO Approach in preparing engineers for Space Industry

    Directory of Open Access Journals (Sweden)

    Daneykin Yury

    2017-01-01

    Full Text Available The necessity to train highly qualified specialists leads to the development of the trajectory that can allow training specialists for the space industry. Several steps have been undertaken to reach this purpose. First, the University founded the Space Instrument Design Center that promotes a wide range of initiatives in the sphere of educating specialists, retraining specialists, carrying out research and collaborating with profiled enterprises. The University introduced Elite Engineering Education system to attract talented specialist and help them to follow individual trajectory to train unique specialist. The paper discusses the targets necessary for achievement to train specialists. Moreover, the paper presents the compliance of the attempts with the CDIO Approach, which is widely used in leading universities to improve engineering programs.

  3. Multi-hazard approaches to civil infrastructure engineering

    CERN Document Server

    LaFave, James

    2016-01-01

    This collection focuses on the development of novel approaches to address one of the most pressing challenges of civil engineering, namely the mitigation of natural hazards. Numerous engineering books to date have focused on, and illustrate considerable progress toward, mitigation of individual hazards (earthquakes, wind, and so forth.). The current volume addresses concerns related to overall safety, sustainability and resilience of the built environment when subject to multiple hazards: natural disaster events that are concurrent and either correlated (e.g., wind and surge); uncorrelated (e.g., earthquake and flood); cascading (e.g., fire following earthquake); or uncorrelated and occurring at different times (e.g., wind and earthquake). The authors examine a range of specific topics including methodologies for vulnerability assessment of structures, new techniques to reduce the system demands through control systems; instrumentation, monitoring and condition assessment of structures and foundations; new te...

  4. Current approaches to electrospun nanofibers for tissue engineering

    International Nuclear Information System (INIS)

    Rim, Nae Gyune; Shin, Heungsoo; Shin, Choongsoo S

    2013-01-01

    The ultimate goal of tissue engineering is to replace damaged tissues by applying engineering technology and the principles of life sciences. To successfully engineer a desirable tissue, three main elements of cells, scaffolds and growth factors need to be harmonized. Biomaterial-based scaffolds serve as a critical platform both to support cell adhesion and to deliver growth factors. Various methods of fabricating scaffolds have been investigated. One recently developed method that is growing in popularity is called electrospinning. Electrospinning is known for its capacity to make fibrous and porous structures that are similar to natural extracellular matrix (ECM). Other advantages to electrospinning include its ability to create relatively large surface to volume ratios, its ability to control fiber size from micro- to nano-scales and its versatility in material choice. Although early work with electrospun fibers has shown promise in the regeneration of certain types of tissues, further modification of their chemical, biological and mechanical properties would permit future advancements. In this paper, current approaches to the development of modular electrospun fibers as scaffolds for tissue engineering are discussed. Their chemical and physical characteristics can be tuned for the regeneration of specific target tissues by co-spinning of multiple materials and by post-modification of the surface of electrospun fibers. In addition, topology or structure can also be controlled to elicit specific responses from cells and tissues. The selection of proper polymers, suitable surface modification techniques and the control of the dimension and arrangement of the fibrous structure of electrospun fibers can offer versatility and tissue specificity, and therefore provide a blueprint for specific tissue engineering applications. (paper)

  5. Engineering approach to model and compute electric power markets settlements

    International Nuclear Information System (INIS)

    Kumar, J.; Petrov, V.

    2006-01-01

    Back-office accounting settlement activities are an important part of market operations in Independent System Operator (ISO) organizations. A potential way to measure ISO market design correctness is to analyze how well market price signals create incentives or penalties for creating an efficient market to achieve market design goals. Market settlement rules are an important tool for implementing price signals which are fed back to participants via the settlement activities of the ISO. ISO's are currently faced with the challenge of high volumes of data resulting from the increasing size of markets and ever-changing market designs, as well as the growing complexity of wholesale energy settlement business rules. This paper analyzed the problem and presented a practical engineering solution using an approach based on mathematical formulation and modeling of large scale calculations. The paper also presented critical comments on various differences in settlement design approaches to electrical power market design, as well as further areas of development. The paper provided a brief introduction to the wholesale energy market settlement systems and discussed problem formulation. An actual settlement implementation framework and discussion of the results and conclusions were also presented. It was concluded that a proper engineering approach to this domain can yield satisfying results by formalizing wholesale energy settlements. Significant improvements were observed in the initial preparation phase, scoping and effort estimation, implementation and testing. 5 refs., 2 figs

  6. An Event-driven, Value-based, Pull Systems Engineering Scheduling Approach

    Science.gov (United States)

    2012-03-01

    combining a services approach to systems engineering with a kanban -based scheduling system. It provides the basis for validating the approach with...agent-based simulations. Keywords-systems engineering; systems engineering process; lean; kanban ; process simulation I. INTRODUCTION AND BACKGROUND...approaches [8], [9], we are investigating the use of flow-based pull scheduling techniques ( kanban systems) in a rapid response development

  7. Process support for Opticam: a concurrent engineering approach

    Science.gov (United States)

    Czajkowski, Walter C.; Tipps, Joe D., Jr.

    1992-12-01

    Although the principles of concurrent engineering and rapid product cycles are not new concepts in the industrial sector, the optics manufacturing industry has witnessed few technological advances since the 1940's. At present the optics industry maintains outdated stand-alone manufacturing equipment and systems that do little to foster integration or communications. 'Islands of Technology', spawned from the latest offerings of CNC controlled equipment, are generally stand alone systems incapable of supporting communication with other process equipment, not to mention the total business enterprise. This approach increases the cost in design and manufacture of optical systems while negatively impacting competitiveness in the global marketplace.

  8. Energy systems a new approach to engineering thermodynamics

    CERN Document Server

    Gicquel, Renaud

    2011-01-01

    Forewords, About the Author, General introduction, Structure of the book, Objectives, A working tool on many levels, Mind Maps, List of Symbols, Conversion FactorsI First Steps in Engineering Thermodynamics1 A New Educational Paradigm1.1 Introduction1.2 General remarks on the evolution of training specifi cations1.3 Specifi cs of applied thermodynamics teaching1.4 A new educational paradigm1.5 Diapason modules1.6 A three-step progressive approach1.7 Main pedagogic innovations brought by Thermoptim1.8 Digital resources of the Thermoptim-UNIT portal1.9 Comparison with other tools with teaching p

  9. Sustainable solid waste management a systems engineering approach

    CERN Document Server

    Chang, N

    2015-01-01

    Interactions between human activities and the environment are complicated and often difficult to quantify. In many occasions, judging where the optimal balance should lie among environmental protection, social well-being, economic growth, and technological progress is complex. The use of a systems engineering approach will fill in the gap contributing to how we understand the intricacy by a holistic way and how we generate better sustainable solid waste management practices. This book aims to advance interdisciplinary understanding of intertwined facets between policy and technology relevant to solid waste management issues interrelated to climate change, land use, economic growth, environmental pollution, industrial ecology, and population dynamics.

  10. Molecular basis of glyphosate resistance: Different approaches through protein engineering

    Science.gov (United States)

    Pollegioni, Loredano; Schonbrunn, Ernst; Siehl, Daniel

    2011-01-01

    Glyphosate (N-phosphonomethyl-glycine) is the most-used herbicide in the world: glyphosate-based formulations exhibit broad-spectrum herbicidal activity with minimal human and environmental toxicity. The extraordinary success of this simple small molecule is mainly due to the high specificity of glyphosate towards the plant enzyme enolpyruvylshikimate-3-phosphate synthase in the shikimate pathway leading to biosynthesis of aromatic amino acids. Starting in 1996, transgenic glyphosate-resistant plants were introduced thus allowing the application of the herbicide to the crop (post-emergence) to remove emerged weeds without crop damage. This review focuses on the evolution of mechanisms of resistance to glyphosate as obtained through natural diversity, the gene shuffling approach to molecular evolution, and a rational, structure-based approach to protein engineering. In addition, we offer rationale for the means by which the modifications made have had their intended effect. PMID:21668647

  11. Some approaches to system reliability improvement in engineering design

    International Nuclear Information System (INIS)

    Shen, Kecheng.

    1990-01-01

    In this thesis some approaches to system reliability improvement in engineering design are studied. In particular, the thesis aims at developing alternative methodologies for ranking of component importance which are more related to the design practice and which are more useful in system synthesis than the existing ones. It also aims at developing component reliability models by means of stress-strength interference which will enable both component reliability prediction and design for reliability. A new methodology for ranking of component importance is first developed based on the notion of the increase of the expected system yield. This methodology allows for incorporation of different improvement actions at the component level such as parallel redundancy, standby redundancy, burn-in, minimal repair and perfect replacement. For each of these improvement actions, the increase of system reliability is studied and used as the component importance measure. A possible connection between the commonly known models of component lifetimes and the stress-strength interference models is suggested. Under some general conditions the relationship between component failure rate and the stress and strength distribution characteristics is studied. A heuristic approach for obtaining bounds on failure probability through stress-strength interference is also presented. A case study and a worked example are presented, which illustrate and verify the developed importance measures and their applications in the analytical as well as synthetical work of engineering design. (author)

  12. A machine-learning approach for computation of fractional flow reserve from coronary computed tomography.

    Science.gov (United States)

    Itu, Lucian; Rapaka, Saikiran; Passerini, Tiziano; Georgescu, Bogdan; Schwemmer, Chris; Schoebinger, Max; Flohr, Thomas; Sharma, Puneet; Comaniciu, Dorin

    2016-07-01

    Fractional flow reserve (FFR) is a functional index quantifying the severity of coronary artery lesions and is clinically obtained using an invasive, catheter-based measurement. Recently, physics-based models have shown great promise in being able to noninvasively estimate FFR from patient-specific anatomical information, e.g., obtained from computed tomography scans of the heart and the coronary arteries. However, these models have high computational demand, limiting their clinical adoption. In this paper, we present a machine-learning-based model for predicting FFR as an alternative to physics-based approaches. The model is trained on a large database of synthetically generated coronary anatomies, where the target values are computed using the physics-based model. The trained model predicts FFR at each point along the centerline of the coronary tree, and its performance was assessed by comparing the predictions against physics-based computations and against invasively measured FFR for 87 patients and 125 lesions in total. Correlation between machine-learning and physics-based predictions was excellent (0.9994, P machine-learning algorithm with a sensitivity of 81.6%, a specificity of 83.9%, and an accuracy of 83.2%. The correlation was 0.729 (P machine-learning model on a workstation with 3.4-GHz Intel i7 8-core processor. Copyright © 2016 the American Physiological Society.

  13. A systems-level approach for metabolic engineering of yeast cell factories.

    Science.gov (United States)

    Kim, Il-Kwon; Roldão, António; Siewers, Verena; Nielsen, Jens

    2012-03-01

    The generation of novel yeast cell factories for production of high-value industrial biotechnological products relies on three metabolic engineering principles: design, construction, and analysis. In the last two decades, strong efforts have been put on developing faster and more efficient strategies and/or technologies for each one of these principles. For design and construction, three major strategies are described in this review: (1) rational metabolic engineering; (2) inverse metabolic engineering; and (3) evolutionary strategies. Independent of the selected strategy, the process of designing yeast strains involves five decision points: (1) choice of product, (2) choice of chassis, (3) identification of target genes, (4) regulating the expression level of target genes, and (5) network balancing of the target genes. At the construction level, several molecular biology tools have been developed through the concept of synthetic biology and applied for the generation of novel, engineered yeast strains. For comprehensive and quantitative analysis of constructed strains, systems biology tools are commonly used and using a multi-omics approach. Key information about the biological system can be revealed, for example, identification of genetic regulatory mechanisms and competitive pathways, thereby assisting the in silico design of metabolic engineering strategies for improving strain performance. Examples on how systems and synthetic biology brought yeast metabolic engineering closer to industrial biotechnology are described in this review, and these examples should demonstrate the potential of a systems-level approach for fast and efficient generation of yeast cell factories. © 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  14. Cell sheet approach for tissue engineering and regenerative medicine.

    Science.gov (United States)

    Matsuura, Katsuhisa; Utoh, Rie; Nagase, Kenichi; Okano, Teruo

    2014-09-28

    After the biotech medicine era, regenerative medicine is expected to be an advanced medicine that is capable of curing patients with difficult-to-treat diseases and physically impaired function. Our original scaffold-free cell sheet-based tissue engineering technology enables transplanted cells to be engrafted for a long time, while fully maintaining their viability. This technology has already been applied to various diseases in the clinical setting, including the cornea, esophagus, heart, periodontal ligament, and cartilage using autologous cells. Transplanted cell sheets not only replace the injured tissue and compensate for impaired function, but also deliver growth factors and cytokines in a spatiotemporal manner over a prolonged period, which leads to promotion of tissue repair. Moreover, the integration of stem cell biology and cell sheet technology with sufficient vascularization opens possibilities for fabrication of human three-dimensional vascularized dense and intact tissue grafts for regenerative medicine to parenchymal organs. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. An integrated systems engineering approach to aircraft design

    Science.gov (United States)

    Price, M.; Raghunathan, S.; Curran, R.

    2006-06-01

    The challenge in Aerospace Engineering, in the next two decades as set by Vision 2020, is to meet the targets of reduction of nitric oxide emission by 80%, carbon monoxide and carbon dioxide both by 50%, reduce noise by 50% and of course with reduced cost and improved safety. All this must be achieved with expected increase in capacity and demand. Such a challenge has to be in a background where the understanding of physics of flight has changed very little over the years and where industrial growth is driven primarily by cost rather than new technology. The way forward to meet the challenges is to introduce innovative technologies and develop an integrated, effective and efficient process for the life cycle design of aircraft, known as systems engineering (SE). SE is a holistic approach to a product that comprises several components. Customer specifications, conceptual design, risk analysis, functional analysis and architecture, physical architecture, design analysis and synthesis, and trade studies and optimisation, manufacturing, testing validation and verification, delivery, life cycle cost and management. Further, it involves interaction between traditional disciplines such as Aerodynamics, Structures and Flight Mechanics with people- and process-oriented disciplines such as Management, Manufacturing, and Technology Transfer. SE has become the state-of-the-art methodology for organising and managing aerospace production. However, like many well founded methodologies, it is more difficult to embody the core principles into formalised models and tools. The key contribution of the paper will be to review this formalisation and to present the very latest knowledge and technology that facilitates SE theory. Typically, research into SE provides a deeper understanding of the core principles and interactions, and helps one to appreciate the required technical architecture for fully exploiting it as a process, rather than a series of events. There are major issues as

  16. Theoretical and methodological approaches to the diagnosis of the region's state material reservation system status

    Directory of Open Access Journals (Sweden)

    Aleksandr Anatol'evich Kuklin

    2011-09-01

    Full Text Available This paper reviews the structural components of the state reserve theory with elements of decomposition and tools for studies in separate directions. The system of state material reserve, which includes the following components: economy - people - natural environment - is a necessary and sufficient reserve for their operation and development which is having the ability to respond to short-, medium- and long-term fluctuations in the economy and consider the risks of adverse factors appliance. It was determined that a necessary and sufficient reserve for the operation and development of the region is a major factor in ensuring its economic security. A method of diagnostics for the state material reserve system within the economic security of the region is presented and described. The approbation of the methodological apparatus for the assessment of the state material reserve by the example on the Ural Federal District was done.

  17. Fatigue in engineering structures. A three fold analysis approach

    International Nuclear Information System (INIS)

    Malik, Afzaal M.; Qureshi, Ejaz M.; Dar, Naeem Ullah; Khan, Iqbal

    2007-01-01

    The integrity in most of the engineering structures in influenced by the presence of cracks or crack like defects. These structures fail, even catastrophically if a crack greater than a critically safe size exist. Although most of the optimal designed structures are initially free from critical cracks, sub-critical cracks can lead to failures under cyclic loadings, called fatigue crack growth. It is nearly impractical to prevent sub-critical crack growth in engineering structures particularly in crack sensitive structures like most of the structures in nuclear, aerospace and aeronautical domains. However, it is essential to predict the fatigue crack growth for these structures to preclude the in service failures causing loss of assets. The present research presents an automatic procedure for the prediction of fatigue crack growth in three dimensional engineering structures and the key data for the fracture mechanics based design: the stress intensity factors. Three fold analysis procedures are adopted to investigate the effects of repetitive (cyclic) loadings on the fatigue life of different geometries of aluminum alloy 2219-O. A general purpose Finite Element (FE) Code ANSYS-8.0 is used to predict/estimate the fatigue life of the geometries. Computer codes utilizing the Green's Function are developed to calculate the stress intensity factors. Another code based on superposition technique presented by Shivakumara and Foreman is developed to calculate the fatigue crack growth rate, fatigue life (No. of loading cycles are developed to validate the results and finally full scale laboratory tests are conducted for the comparison of the results. The results showing a close co-relation between the different techniques employed gives the promising feature of the analysis approach for the future work. (author)

  18. Complex approach in telecommunication engineering education: develop engineering skills by a team project

    Directory of Open Access Journals (Sweden)

    Scripcariu Luminița

    2017-01-01

    Full Text Available This paper provides an overview of the educational process of telecommunication engineering students by presenting the preparation of a team project focused on information security. Our educational approach combines basic knowledge such as mathematics with specialized engineering notions and various skills. The project theme is to design, implement and test an encryption algorithm. Students are provided with online courses, specific software programs and Internet access. They have to choose an encryption algorithm, to study its details and to write the script of the encryption algorithm in MATLAB program. The algorithm is implemented in C/C++ programming language and tested. Finally, a concurrent team tries to break the algorithm by finding the decryption key. It is an interactive approach which combines various education methods including gaming concepts. The covered topics provide students professional outcomes such as knowledge and use of specific mathematical tools and software environments (C/C ++ programming languages, MATLAB, abilities to design, develop, implement and test software algorithms. The project also provides transversal outcomes such as ability to team work, skills of computer use and information technology and capability to take responsibilities. Creativity is also encouraged by extending the algorithm to other encryption key lengths than the usual ones.

  19. Failure of Engineering Artifacts : A Life Cycle Approach

    NARCIS (Netherlands)

    Del Frate, L.

    2012-01-01

    Failure is a central notion both in ethics of engineering and in engineering practice. Engineers devote considerable resources to assure their products will not fail and considerable progress has been made in the development of tools and methods for understanding and avoiding failure. Engineering

  20. Approaches to nontraditional delivery of nuclear engineering education

    International Nuclear Information System (INIS)

    Malaviya, B.K.

    1991-01-01

    At Rensselaer Polytechnic Institute, the faculty of the nuclear engineering and engineering physics department have, over the years, been involved in a variety of such approaches in response to the changing needs of nuclear industry personnel. A number of different types of short course and workshop programs have been developed and implemented both on and off campus in such areas as basic nuclear technology, reactor design computer codes and applications, nuclear power plant design and maintenance, reactor operations, health physics, modern developments in boiling heat transfer and two-phase flow, and probabilistic risk assessment. Customized coursed tailored to meet the particular needs of personnel in specialized areas can also be offered on specific industrial site locations, generally resulting in substantial savings of time as well as costs associated with tuition, travel, lodging. The Rensselaer Satellite Video Program (RSVP) brings the latest technological aids to the nontraditional delivery of courses and provides the facilities and opportunities for off-campus students and professional personnel to participate in regular academic programs and courses without leaving their industrial sites

  1. A Systems Engineering Approach to Quality Assurance for Aerospace Testing

    Science.gov (United States)

    Shepherd, Christena C.

    2015-01-01

    On the surface, it appears that AS91001 has little to say about how to apply a Quality Management System (QMS) to major aerospace test programs (or even smaller ones). It also appears that there is little in the quality engineering Body of Knowledge (BOK)2 that applies to testing, unless it is nondestructive examination (NDE), or some type of lab or bench testing associated with the manufacturing process. However, if one examines: a) how the systems engineering (SE) processes are implemented throughout a test program; and b) how these SE processes can be mapped to the requirements of AS9100, a number of areas for involvement of the quality professional are revealed. What often happens is that quality assurance during a test program is limited to inspections of the test article; what could be considered a manufacturing al fresco approach. This limits the quality professional and is a disservice to the programs and projects, since there are a number of ways that quality can enhance critical processes, and support efforts to improve risk reduction, efficiency and effectiveness.

  2. Personalized Education Approaches for Chemical Engineering and Relevant Majors

    Directory of Open Access Journals (Sweden)

    Zhao Feng-qing

    2016-01-01

    Full Text Available Personalized education has drawn increasing attention in universities these years. With the purpose of improving the studentss’ comprehensive ability and developing teaching strategies to ensure students’ education is tailored to their needs, we proposed Three-Stage Approach (TSA to enhance personalized education for chemical engineering and relevant majors: professional tutorial system--equipping with professional guidance teachers for freshman students to guide their learning activities and provide professional guidance; open experimental project--setting up open experimental projects for sophomore and junior students to choose freely; individualized education module--setting up 10 different individualized education modules for senior students to select. After years of practice, the personalized education model is improved day by day and proved effective and fruitful.

  3. Determining reserve requirements in DK1 area of Nord Pool using a probabilistic approach

    DEFF Research Database (Denmark)

    Saez Gallego, Javier; Morales González, Juan Miguel; Madsen, Henrik

    2014-01-01

    area of Nord Pool, where reserves are scheduled prior to the closure of the day-ahead market. The risk of the solution under the resulting reserve schedule is controlled by two measures: the LOLP (Loss-of-Load Probability) and the CVaR (Conditional Value at Risk). Results show that during the case...

  4. A comprehensive environmental assessment approach to engineered nanomaterials.

    Science.gov (United States)

    Davis, J Michael

    2013-01-01

    The anticipated benefits of engineered nanomaterials (ENMs) should be weighed against their possible negative impacts. Comprehensive environmental assessment (CEA) provides a means of evaluating such trade-offs in a holistic and systematic manner. CEA consists of both a framework for organizing information and a process for using collective judgment to identify and prioritize the issues presented by ENMs. As a meta-assessment approach, CEA is designed to assist both research planners and risk managers by building on various assessment and analytic tools used by risk assessors. Given the immature state of the science for ENMs, CEA is currently being primarily used for prioritizing research directions. Therefore, highlights of case studies of selected ENM applications are presented to illustrate how CEA has been applied thus far to help guide research efforts to support future assessment efforts. In addition, CEA is discussed in relation to topical subjects, such as sustainability, transparency, and stakeholder engagement. Finally, comparisons to other life cycle-based assessment approaches directed at ENMs are noted. Copyright © 2012 Wiley Periodicals, Inc.

  5. The catchment based approach using catchment system engineering

    Science.gov (United States)

    Jonczyk, Jennine; Quinn, Paul; Barber, Nicholas; Wilkinson, Mark

    2015-04-01

    The catchment based approach (CaBa) has been championed as a potential mechanism for delivery of environmental directives such as the Water Framework Directive in the UK. However, since its launch in 2013, there has been only limited progress towards achieving sustainable, holistic management, with only a few of examples of good practice ( e.g. from the Tyne Rivers trust). Common issues with developing catchment plans over a national scale include limited data and resources to identify issues and source of those issues, how to systematically identify suitable locations for measures or suites of measures that will have the biggest downstream impact and how to overcome barriers for implementing solutions. Catchment System Engineering (CSE) is an interventionist approach to altering the catchment scale runoff regime through the manipulation of hydrological flow pathways throughout the catchment. A significant component of the runoff generation can be managed by targeting hydrological flow pathways at source, such as overland flow, field drain and ditch function, greatly reducing erosive soil losses. Coupled with management of farm nutrients at source, many runoff attenuation features or measures can be co-located to achieve benefits for water quality and biodiversity. A catchment, community-led mitigation measures plan using the CSE approach will be presented from a catchment in Northumberland, Northern England that demonstrate a generic framework for identification of multi-purpose features that slow, store and filter runoff at strategic locations in the landscape. Measures include within-field barriers, edge of field traps and within-ditch measures. Progress on the implementation of measures will be reported alongside potential impacts on the runoff regime at both local and catchment scale and costs.

  6. Band gap engineering via doping: A predictive approach

    Energy Technology Data Exchange (ETDEWEB)

    Andriotis, Antonis N., E-mail: andriot@iesl.forth.gr [Institute of Electronic Structure and Laser, FORTH, P.O. Box 1527, 71110 Heraklio, Crete (Greece); Menon, Madhu, E-mail: super250@uky.edu [Department of Physics and Astronomy and Center for Computational Sciences, University of Kentucky, Lexington, Kentucky 40506 (United States)

    2015-03-28

    We employ an extension of Harrison's theory at the tight binding level of approximation to develop a predictive approach for band gap engineering involving isovalent doping of wide band gap semiconductors. Our results indicate that reasonably accurate predictions can be achieved at qualitative as well as quantitative levels. The predictive results were checked against ab initio ones obtained at the level of DFT/SGGA + U approximation. The minor disagreements between predicted and ab initio results can be attributed to the electronic processes not incorporated in Harrison's theory. These include processes such as the conduction band anticrossing [Shan et al., Phys. Rev. Lett. 82, 1221 (1999); Walukiewicz et al., Phys. Rev. Lett. 85, 1552 (2000)] and valence band anticrossing [Alberi et al., Phys. Rev. B 77, 073202 (2008); Appl. Phys. Lett. 92, 162105 (2008); Appl. Phys. Lett. 91, 051909 (2007); Phys. Rev. B 75, 045203 (2007)], as well as the multiorbital rehybridization. Another cause of disagreement between the results of our predictive approach and the ab initio ones is shown to be the result of the shift of Fermi energy within the impurity band formed at the edge of the valence band maximum due to rehybridization. The validity of our approach is demonstrated with example applications for the systems GaN{sub 1−x}Sb{sub x}, GaP{sub 1−x}Sb{sub x}, AlSb{sub 1−x}P{sub x}, AlP{sub 1−x}Sb{sub x}, and InP{sub 1−x}Sb{sub x}.

  7. Multidisciplinary and Active/Collaborative Approaches in Teaching Requirements Engineering

    Science.gov (United States)

    Rosca, Daniela

    2005-01-01

    The requirements engineering course is a core component of the curriculum for the Master's in Software Engineering programme, at Monmouth University (MU). It covers the process, methods and tools specific to this area, together with the corresponding software quality issues. The need to produce software engineers with strong teamwork and…

  8. A Novel Approach to Physiology Education for Biomedical Engineering Students

    Science.gov (United States)

    DiCecco, J.; Wu, J.; Kuwasawa, K.; Sun, Y.

    2007-01-01

    It is challenging for biomedical engineering programs to incorporate an indepth study of the systemic interdependence of cells, tissues, and organs into the rigorous mathematical curriculum that is the cornerstone of engineering education. To be sure, many biomedical engineering programs require their students to enroll in anatomy and physiology…

  9. Sustainable Development in Engineering Education: A Pedagogical Approach

    Science.gov (United States)

    Ahrens, A.; Zascerinska, J.

    2012-01-01

    Engineering education is facing a challenge of the development of student engineers' social responsibility in the context of sustainable development. The aim of the research is to analyze efficiency of engineering curriculum in the context of sustainable development underpinning elaboration of pedagogical guidelines on the development of students'…

  10. A Systems Engineering Approach to Electro-Mechanical Actuator Diagnostic and Prognostic Development

    Data.gov (United States)

    National Aeronautics and Space Administration — The authors have formulated a Comprehensive Systems Engineering approach to Electro-Mechanical Actuator (EMA) Prognostics and Health Management (PHM) system...

  11. A robust optimization approach to energy and reserve dispatch in electricity markets

    DEFF Research Database (Denmark)

    Zugno, Marco; Conejo, Antonio J.

    2015-01-01

    To a large extent, electricity markets worldwide still rely on deterministic procedures for clearing energy and reserve auctions. However, increasing shares of the production mix consist of renewable sources whose nature is stochastic and non-dispatchable, as their output is uncertain and cannot...

  12. A Robust Optimization Approach to Energy and Reserve Dispatch in Electricity Markets

    DEFF Research Database (Denmark)

    Zugno, Marco; Conejo, Antonio J.

    To a large extent, electricity markets worldwide still rely on deterministic procedures for clearing energy and reserve auctions. However, larger and larger shares of the production mix consist of renewable sources whose nature is stochastic and non-dispatchable, as their output is not known...

  13. A dynamic programming approach to optimise elephant management in the Maputo Elephant Reserve, Mozambique

    NARCIS (Netherlands)

    Boer, de W.F.; Stigter, J.D.; Ntumi, C.P.

    2003-01-01

    Conservation can go hand-in-hand with exploitation of conservation areas through tourism. Private enterprises are active in local conservation initiatives in Africa. In Mozambique, some of these enterprises have long-term licences for the development of national parks or reserves. The motivation of

  14. A cost sensitive inpatient bed reservation approach to reduce emergency department boarding times.

    Science.gov (United States)

    Qiu, Shanshan; Chinnam, Ratna Babu; Murat, Alper; Batarse, Bassam; Neemuchwala, Hakimuddin; Jordan, Will

    2015-03-01

    Emergency departments (ED) in hospitals are experiencing severe crowding and prolonged patient waiting times. A significant contributing factor is boarding delays where admitted patients are held in ED (occupying critical resources) until an inpatient bed is identified and readied in the admit wards. Recent research has suggested that if the hospital admissions of ED patients can be predicted during triage or soon after, then bed requests and preparations can be triggered early on to reduce patient boarding time. We propose a cost sensitive bed reservation policy that recommends optimal bed reservation times for patients. The policy relies on a classifier that estimates the probability that the ED patient will be admitted using the patient information collected and readily available at triage or right after. The policy is cost sensitive in that it accounts for costs associated with patient admission prediction misclassification as well as costs associated with incorrectly selecting the reservation time. Results from testing the proposed bed reservation policy using data from a VA Medical Center are very promising and suggest significant cost saving opportunities and reduced patient boarding times.

  15. A TOTAL QUALITY MANAGEMENT APPROACH TO CIVIL ENGINEERING CONSULTING

    Directory of Open Access Journals (Sweden)

    G.A.L. Ambrose

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: The article describes the development of a framework for the implementation of a Total Quality Management (TQM approach in the civil consulting industry through the five phases of the typical civil engineering project. For any project to be successful the project team members must take collective and individual responsibility for their role in the project implementation. The organisational goal is “to make money now and in the future”. To achieve this goal the organization must provide value to its clientele. The clients are searching for the silver bullet; double the performance at half the price. TQM provides a means to achieve this goal.

    AFRIKAANSE OPSOMMING: Die artikel beskryf die ontwikkeling van 'n raamwerk vir die implementering van 'n gehaltebestuurstelsel vir die siviele raadgewende bedryf soos dit deelneem aan die vyf fases van 'n tipiese siviele ingenieursprojek. Vir die suksesvolle afhandeling van 'n projek is dit noodsaaklik dat alle projekspanlede gesamentlik en afsonderlik verantwoordelikheid moet aanvaar vir hulle eie betrokkenheid by die projekimplementering. Die organisasie se oogmerk is om “nou en in die toekoms geld te maak”. Ten einde hierdie oogmerk te bereik moet die organisasie waarde vir sy kliënte bied. 'n Gehaltebestuurstelsel voorsien die gereedskap om hierdie doelwit te bereik.

  16. Engineering approach for cost effective operation of industrial pump systems

    Science.gov (United States)

    Krickis, O.; Oleksijs, R.

    2017-10-01

    Power plants operators are persuaded to operate the main equipment such as centrifugal pumps in economically effective way. The operation of pump sets of district heating network at power plants should be done according to prescriptions of the original equipment manufacturer with further implementation of these requirements to distributed control system of the plant. In order to operate industrial pump sets with a small number of malfunctions is necessary to control the duty point of pump sets in H-Q coordinates, which could be complex task in some installations. Alternatively, pump operation control could be organized in H-n (head vs rpm) coordinates, utilizing pressure transmitters in pressure pipeline and value of rpm from variable speed driver. Safe operation range of the pump has to be limited with system parabolas, which prevents the duty point location outside of the predefined operation area. The particular study demonstrates the engineering approach for pump’s safe operation control development in MATLAB/Simulink environment, which allows to simulate the operation of the pump at different capacities in hydraulic system with variable characteristic and to predefine the conditions for efficient simultaneous pump operation in parallel connection.

  17. A unified approach to failure assessment of engineering structures

    International Nuclear Information System (INIS)

    Harrison, R.P.

    1977-01-01

    A codified procedure for the failure assessment of engineering structures is presented which has as its basis the two criteria approach of Dowling and Townley (Int. J. Press. Vessels and Piping; 3:77 (1975)) and the Bilby, Cottrell and Swinden (Proc. R. Soc.; A272:304 (1963)) and Dugdale (J. Mech. Phys. Sol.; 8:100 (1960)) model of yielding ahead of a crack tip. The procedure consists of independently assessing the risk of failure (a) under linear elastic conditions only and (b) under plastic collapse conditions only. These two limiting criteria are then plotted as a co-ordinate point on a Failure Assessment Diagram. From this a measure of the degree of safety of the structure can be obtained. As examples, several of the HSST vessel tests are used to indicate the simplicity and versatility of the procedure. It is shown how maximum allowable pressures or defect sizes can be obtained and how safety factors can be readily incorporated on any of the parameters used in the assessment. It is also demonstrated how helpful the procedure is in designing not only working structures, but also structures that are to be used for testing. (author)

  18. New approach for strategic bidding of Gencos in energy and spinning reserve markets

    International Nuclear Information System (INIS)

    Soleymani, S.; Ranjbar, A.M.; Shirani, A.R.

    2007-01-01

    In restructured and de-regulated power systems, generating companies (Gencos) are responsible for supplying electricity for both energy and reserve markets, which usually operate simultaneously. In this condition, the question is how much and for what price must each Genco generate for each market to maximize its profit, so this paper intends to answer to this question. In this paper, first, the combined energy and reserve markets are considered, and the Nash equilibrium points are determined. Then, the bidding strategies for each Genco at these points will be presented. The bids for the energy and 10 min spinning reserve (TMSR) markets are separated in the second stage, and again, the bidding strategies for each Genco for the two separated markets will be demonstrated. Comparison of the results shows that the separated bidding strategies, while being simplified with the algebraic optimization model and reducing the time consumed, give the same results as the combined ones. The Western System Coordinating Council (WSCC) nine bus test system is employed to illustrate and verify the results of the proposed method. (author)

  19. Developing a New Industrial Engineering Curriculum Using a Systems Engineering Approach

    Science.gov (United States)

    Buyurgan, Nebil; Kiassat, Corey

    2017-01-01

    This paper reports on the development of an engineering curriculum for a new industrial engineering programme at a medium-sized private university in the northeast United States. A systems engineering process has been followed to design and develop the new curriculum. Considering the programme curriculum as a system, first the stakeholders have…

  20. Survey of Traceability Approaches in Model-Driven Engineering

    NARCIS (Netherlands)

    Galvao, I.; Göknil, Arda

    2007-01-01

    Models have been used in various engineering fields to help managing complexity and represent information in different abstraction levels, according to specific notations and stakeholder's viewpoints. Model-Driven Engineering (MDE) gives the basic principles for the use of models as primary

  1. Teaching Technical Translation: An Engineered Approach at Flensburg Polytechnic.

    Science.gov (United States)

    Winkler, Gustav

    All students in the new, unique four-year degree program for technical translators at Flensburg Polytechnic (Germany) must study engineering as well as language and cultural skills, language information technology, and theoretical and practical aspects of translation. The program was conceived and established by engineers with an interest in…

  2. An Alternative Educational Approach for an Inorganic Chemistry Laboratory Course in Industrial and Chemical Engineering

    Science.gov (United States)

    Garces, Andres; Sanchez-Barba, Luis Fernando

    2011-01-01

    We describe an alternative educational approach for an inorganic chemistry laboratory module named "Experimentation in Chemistry", which is included in Industrial Engineering and Chemical Engineering courses. The main aims of the new approach were to reduce the high levels of failure and dropout on the module and to make the content match the…

  3. An Integrated Neuroscience and Engineering Approach to Classifying Human Brain-States

    Science.gov (United States)

    2015-12-22

    AFRL-AFOSR-VA-TR-2016-0037 An Integrated Neuroscience and Engineering Approach to Classifying Human Brain-States Adrian Lee UNIVERSITY OF WASHINGTON...to 14-09-2015 4. TITLE AND SUBTITLE An Integrated Neuroscience and Engineering Approach to Classifying Human Brain- States 5a.  CONTRACT NUMBER 5b...specific cognitive states remains elusive, owing perhaps to limited crosstalk between the fields of neuroscience and engineering. Here, we report a

  4. Arctic Ice Management: an integrated approach to climate engineering

    Science.gov (United States)

    Desch, S. J.; Hartnett, H. E.; Groppi, C. E.; Romaniello, S. J.

    2017-12-01

    The warming climate is having the most rapid and pronounced effects in the high Arctic. The loss of Arctic sea ice is not only changing the physical oceanography of the Arctic Ocean and its coastlines; it is also promoting new conversations about the dangers and benefits for trade, transportation, and industry in the Arctic. The rate of decrease of summer sea ice in the Arctic is currently -300 km3 yr-1, a rate that will lead to complete loss of end-summer sea ice as soon as 2030. Preventing the strong positive feedbacks and increased warming due to sea ice albedo loss must be an important component of climate mitigation strategies. Here, we explore a direct engineering approach we call Arctic Ice Management (AIM) to reduce the loss of Arctic sea ice. We predict that pumping seawater onto the ice surface during the Arctic winter using wind-powered pumps can thicken sea ice by up to 1 m per year, reversing the current loss rates and prolonging the time until the Arctic Ocean is ice-free. Thickening sea ice would not change CO2 levels, which are the underlying cause of ice loss, but it would prevent some of the strongest feedbacks and would buy time to develop the tools and governance systems necessary to achieve carbon-neutrality. We advocate exploration of AIM as a mitigation strategy employed in parallel with CO2 reduction efforts. The opportunity and risk profiles of AIM differ from other geoengineering proposals. While similar in principle to solar radiation management, AIM may present fewer large-scale environmental risks. AIM is separate from greenhouse gas emission reduction or sequestration, but might help prevent accelerated release of methane from thawing permafrost. Further, AIM might be usefully employed at regional and local scales to preserve Arctic ecosystems and possibly reduce the effects of ice-loss induced coastal erosion. Through presentation of the AIM concept, we hope to spark new conversations between scientists, stakeholders, and decision

  5. OPTIMIZATION OF MANAGEMENT APPROACHES: RESERVES GROWTH OF EFFICIENCY OF NR-MANAGEMENT IN THE BUSINESS

    Directory of Open Access Journals (Sweden)

    F. Sh. Fedorova

    2016-01-01

    Full Text Available The article describes one of the possible ways of building more eff ective relationships between managers and subordinates, taking into account variable range of individual motivation, capabilities and potential of people belonging to diff erent types of employees.The topic is urgent due to the changes in modern business processes that require new approaches to management. Goal/objectives. Our aim is to develop an approach to the creation of human resources management model that takes into account not only the knowledge and skills of employees, but also their deeper individual characteristics. The approach accounts for the hierarchy of one's life values and drives, temperament, strains, habitual and unfamiliar social roles, way of thinking, preferred pattern of communication, peculiarities of the behavior in power relations and a host of other features. We suggest that asking them into account is an incredible opportunity for productivity growth and team eff ectiveness improvements.Methodology. The theoretical basis of the article are studies of Russian and foreign authors on the classifications and typologies of personality, of social roles, roles in the team, as well as subordinate types. The article refl ects the results of studies and observations of the authors on the peculiarities of manifestation of diff erent types of people in decision-making and business communications.Results. We suggest the typology of subordinates describing the key characteristics and preferences of representatives of the types. The typology allows to build relationships between managers and subordinates more eff ectively.Conclusions/significance. We propose typology of subordinates that can be used to develop management models focused on certain types of employees. This, in turn, may be useful for structuring of human management, retrieval of unused but eff ective management tools, and for building an eff ective staff -management relations network as a whole to

  6. A Forest Planning Approach with Respect to the Creation of Overmature Reserved Areas in Managed Forests

    Directory of Open Access Journals (Sweden)

    Jan Kašpar

    2015-02-01

    Full Text Available Forest harvest planning to maximize economic benefits also has to consider additional criteria such as the biodiversity functioning of the managed forest. The biodiversity requirements are determined by the size, shape, and distribution of harvest units and forest stands. A multiple criteria approach is presented where the harvesting volume is maximized while the environmental aspects are also considered. Multiple criteria programming and integer programming techniques are used to find an optimal program of forest harvesting with respect to both economic and environmental requirements. The practicality of the model is shown in a case study for one particular forest management unit. Different optimal solutions are calculated depending on changes made to the criteria weights. This model includes strict spatial constraints, multiple objective functions with three objectives, and alternative solutions according to the real manager’s priority. The results show that the spatial pattern and other spatial demands affect the harvest possibilities. It was confirmed that a compromise solution from both forest management and nature conservation could be achieved using the presented harvest scheduling approach.

  7. Engineering the just war: examination of an approach to teaching engineering ethics.

    Science.gov (United States)

    Haws, David R

    2006-04-01

    The efficiency of engineering applied to civilian projects sometimes threatens to run away with the social agenda, but in military applications, engineering often adds a devastating sleekness to the inevitable destruction of life. The relative crudeness of terrorism (e.g., 9/11) leaves a stark after-image, which belies the comparative insignificance of random (as opposed to orchestrated) belligerence. Just as engineering dwarfs the bricolage of vernacular design 'moving us past the appreciation of brush-strokes, so to speak' the scale of engineered destruction makes it difficult to focus on the charred remains of individual lives. Engineers need to guard against the inappropriate military subsumption of their effort. Fortunately, the ethics of warfare has been an ongoing topic of discussion for millennia. This paper will examine the university core class I've developed (The Moral Dimensions of Technology) to meet accreditation requirements in engineering ethics, and the discussion with engineering and non-engineering students focused by the life of electrical engineer Vannevar Bush, with selected readings in moral philosophy from the Dao de Jing, Lao Tze, Cicero, Aurelius Augustinus, Kant, Annette Baier, Peter Singer, Elizabeth Anscombe, Philippa Foot, and Judith Thomson.

  8. Expert System Approach For Generating And Evaluating Engine Design Alternatives

    Science.gov (United States)

    Shen, Stewart N. T.; Chew, Meng-Sang; Issa, Ghassan F.

    1989-03-01

    Artificial intelligence is becoming an increasingly important subject of study for computer scientists, engineering designers, as well as professionals in other fields. Even though AI technology is a relatively new discipline, many of its concepts have already found practical applications. Expert systems, in particular, have made significant contributions to technologies in such fields as business, medicine, engineering design, chemistry, and particle physics. This paper describes an expert system developed to aid the mechanical designer with the preliminary design of variable-stroke internal-combustion engines. The expert system accomplished its task by generating and evaluating a large number of design alternatives represented in the form of graphs. Through the application of structural and design rules directly to the graphs, optimal and near optimal preliminary design configurations of engines are deduced.

  9. A resilience engineering approach to assess major accident risks

    DEFF Research Database (Denmark)

    Hollnagel, E.

    2013-01-01

    This chapter describes how the principles of Resilience Engineering can be used to make a risk assessment of an Integrated Operations (IO) scenario. It refers to the case study provided in Chapter 12.......This chapter describes how the principles of Resilience Engineering can be used to make a risk assessment of an Integrated Operations (IO) scenario. It refers to the case study provided in Chapter 12....

  10. Emergence of scaffold-free approaches for tissue engineering musculoskeletal cartilages.

    Science.gov (United States)

    DuRaine, Grayson D; Brown, Wendy E; Hu, Jerry C; Athanasiou, Kyriacos A

    2015-03-01

    This review explores scaffold-free methods as an additional paradigm for tissue engineering. Musculoskeletal cartilages-for example articular cartilage, meniscus, temporomandibular joint disc, and intervertebral disc-are characterized by low vascularity and cellularity, and are amenable to scaffold-free tissue engineering approaches. Scaffold-free approaches, particularly the self-assembling process, mimic elements of developmental processes underlying these tissues. Discussed are various scaffold-free approaches for musculoskeletal cartilage tissue engineering, such as cell sheet engineering, aggregation, and the self-assembling process, as well as the availability and variety of cells used. Immunological considerations are of particular importance as engineered tissues are frequently of allogeneic, if not xenogeneic, origin. Factors that enhance the matrix production and mechanical properties of these engineered cartilages are also reviewed, as the fabrication of biomimetically suitable tissues is necessary to replicate function and ensure graft survival in vivo. The concept of combining scaffold-free and scaffold-based tissue engineering methods to address clinical needs is also discussed. Inasmuch as scaffold-based musculoskeletal tissue engineering approaches have been employed as a paradigm to generate engineered cartilages with appropriate functional properties, scaffold-free approaches are emerging as promising elements of a translational pathway not only for musculoskeletal cartilages but for other tissues as well.

  11. Hybrid Engine Powered City Car: Fuzzy Controlled Approach

    Science.gov (United States)

    Rahman, Ataur; Mohiuddin, AKM; Hawlader, MNA; Ihsan, Sany

    2017-03-01

    This study describes a fuzzy controlled hybrid engine powered car. The car is powered by the lithium ion battery capacity of 1000 Wh is charged by the 50 cc hybrid engine and power regenerative mode. The engine is operated with lean mixture at 3000 rpm to charge the battery. The regenerative mode that connects with the engine generates electrical power of 500-600 W for the deceleration of car from 90 km/h to 20 km/h. The regenerated electrical power has been used to power the air-conditioning system and to meet the other electrical power. The battery power only used to propel the car. The regenerative power also found charging the battery for longer operation about 40 minutes and more. The design flexibility of this vehicle starts with whole-vehicle integration based on radical light weighting, drag reduction, and accessory efficiency. The energy efficient hybrid engine cut carbon dioxide (CO2) and nitrogen oxides (N2O) emission about 70-80% as the loads on the crankshaft such as cam-follower and its associated rotating components are replaced by electromagnetic systems, and the flywheel, alternator and starter motor are replaced by a motor generator. The vehicle was tested and found that it was able to travel 70 km/litre with the power of hybrid engine.

  12. Engineering spinal fusion: evaluating ceramic materials for cell based tissue engineered approaches

    NARCIS (Netherlands)

    Wilson, C.E.

    2011-01-01

    The principal aim of this thesis was to advance the development of tissue engineered posterolateral spinal fusion by investigating the potential of calcium phosphate ceramic materials to support cell based tissue engineered bone formation. This was accomplished by developing several novel model

  13. A Novel Evolutionary Engineering Design Approach for Mixed-Domain Systems

    DEFF Research Database (Denmark)

    Fan, Zhun; Hu, J.; Seo, K.

    2004-01-01

    This paper presents an approach to engineering design of mixed-domain dynamic systems. The approach aims at system-level design and has two key features: first, it generates engineering designs that satisfy predefined specifications in an automatic manner; second, it can design systems belonging...... often encountered in evolutionary computation, a HFC (Hierarchical Fair Competition) model is adopted in this work. Examples of an analog filter design and a MEM filter design illustrate the application of the approach....

  14. Reducing Diesel Engine Emission Using Reactivity Controlled Approach

    Directory of Open Access Journals (Sweden)

    Osama Hasib Ghazal

    2018-01-01

    Full Text Available Several automobile manufacturers are interested in investigating of dual fuel internal combustion engines, due to high efficiencand low emissions. Many alternative fuels have been used in dual fuel mode for IC engine, such as methane, hydrogen, and natural gas. In the present study, a reactivity controlled compression ignition (RCCI engine using gasoline/diesel (G/D dual fuel has been investigated. The effectof mixing gasoline with diesel fuel on combustion characteristic, engine performance and emissions has been studied. The gasoline was injected in the engine intake port, to produce a homogeneous mixture with air. The diesel fuel was injected directly to the combustion chamber during compression stroke to initiate the combustion process. A direct injection compression ignition engine has been built and simulated using ANSYS Forte professional code. The gasoline amount in the simulation varied from (50%-80% by volume. The diesel fuel was injected to the cylinder in two stages. The model has been validated and calibrated for neat diesel fuel using available data from the literature. The results show that the heat release rate and the cylinder pressure increased when the amount of added gasoline is between 50%-60% volume of the total injected fuels, compared to the neat diesel fuel. Further addition of gasoline will have a contrary effect. In addition, the combustion duration is extended drastically when the gasoline ratio is higher than 60% which results in an incomplete combustion. The NO emission decreased drastically as the gasoline ratio increased. Moreover, addition of gasoline to the mixture increased the engine power, thermal efficienc and combustion efficienc compared to neat diesel fuel.

  15. State-of-the-art protein engineering approaches using biological macromolecules: A review from immobilization to implementation view point.

    Science.gov (United States)

    Bilal, Muhammad; Iqbal, Hafiz M N; Guo, Shuqi; Hu, Hongbo; Wang, Wei; Zhang, Xuehong

    2018-03-01

    Over the past years, technological and scientific advances have proven biocatalysis as a sustainable alternative than traditional chemical catalysis including organo- or metallocatalysis. In this context, immobilization based approaches represent simple but effective routes for engineering enzyme catalysts with higher activities than wild-type derivatives. Many enzymes including oxidoreductases have been engineered by rational and directed evolution, to realize the catalytic activity, enantioselectivity, and stability attributes which are essential for their biotechnological exploitation. Induce yet stable activity in enzyme catalysis offer new insights and motivation to engineer efficient catalysts for practical and commercial purposes. It has now become possible to envisage substrate accessibility to the catalytic site of the enzyme by current computational capabilities that reduce the experimental work related to the enzyme selection, screening, and engineering. Herein, state-of-the-art protein engineering approaches for improving enzymatic activities including chemical modification, directed evolution, and rational design or their combination methods are discussed. The emphasis is also given to the applications of the resulting tailored catalysts ranging from fine chemicals to novel pharmaceutical compounds that use biocatalysts as a vital step. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Mapping Habitats and Developing Baselines in Offshore Marine Reserves with Little Prior Knowledge: A Critical Evaluation of a New Approach.

    Directory of Open Access Journals (Sweden)

    Emma Lawrence

    Full Text Available The recently declared Australian Commonwealth Marine Reserve (CMR Network covers a total of 3.1 million km2 of continental shelf, slope, and abyssal habitat. Managing and conserving the biodiversity values within this network requires knowledge of the physical and biological assets that lie within its boundaries. Unfortunately very little is known about the habitats and biological assemblages of the continental shelf within the network, where diversity is richest and anthropogenic pressures are greatest. Effective management of the CMR estate into the future requires this knowledge gap to be filled efficiently and quantitatively. The challenge is particularly great for the shelf as multibeam echosounder (MBES mapping, a key tool for identifying and quantifying habitat distribution, is time consuming in shallow depths, so full coverage mapping of the CMR shelf assets is unrealistic in the medium-term. Here we report on the results of a study undertaken in the Flinders Commonwealth Marine Reserve (southeast Australia designed to test the benefits of two approaches to characterising shelf habitats: (i MBES mapping of a continuous (~30 km2 area selected on the basis of its potential to include a range of seabed habitats that are potentially representative of the wider area, versus; (ii a novel approach that uses targeted mapping of a greater number of smaller, but spatially balanced, locations using a Generalized Random Tessellation Stratified sample design. We present the first quantitative estimates of habitat type and sessile biological communities on the shelf of the Flinders reserve, the former based on three MBES analysis techniques. We contrast the quality of information that both survey approaches offer in combination with the three MBES analysis methods. The GRTS approach enables design based estimates of habitat types and sessile communities and also identifies potential biodiversity hotspots in the northwest corner of the reserve's IUCN

  17. Mapping Habitats and Developing Baselines in Offshore Marine Reserves with Little Prior Knowledge: A Critical Evaluation of a New Approach.

    Science.gov (United States)

    Lawrence, Emma; Hayes, Keith R; Lucieer, Vanessa L; Nichol, Scott L; Dambacher, Jeffrey M; Hill, Nicole A; Barrett, Neville; Kool, Johnathan; Siwabessy, Justy

    2015-01-01

    The recently declared Australian Commonwealth Marine Reserve (CMR) Network covers a total of 3.1 million km2 of continental shelf, slope, and abyssal habitat. Managing and conserving the biodiversity values within this network requires knowledge of the physical and biological assets that lie within its boundaries. Unfortunately very little is known about the habitats and biological assemblages of the continental shelf within the network, where diversity is richest and anthropogenic pressures are greatest. Effective management of the CMR estate into the future requires this knowledge gap to be filled efficiently and quantitatively. The challenge is particularly great for the shelf as multibeam echosounder (MBES) mapping, a key tool for identifying and quantifying habitat distribution, is time consuming in shallow depths, so full coverage mapping of the CMR shelf assets is unrealistic in the medium-term. Here we report on the results of a study undertaken in the Flinders Commonwealth Marine Reserve (southeast Australia) designed to test the benefits of two approaches to characterising shelf habitats: (i) MBES mapping of a continuous (~30 km2) area selected on the basis of its potential to include a range of seabed habitats that are potentially representative of the wider area, versus; (ii) a novel approach that uses targeted mapping of a greater number of smaller, but spatially balanced, locations using a Generalized Random Tessellation Stratified sample design. We present the first quantitative estimates of habitat type and sessile biological communities on the shelf of the Flinders reserve, the former based on three MBES analysis techniques. We contrast the quality of information that both survey approaches offer in combination with the three MBES analysis methods. The GRTS approach enables design based estimates of habitat types and sessile communities and also identifies potential biodiversity hotspots in the northwest corner of the reserve's IUCN zone IV, and in

  18. An engineering approach to an integrated value proposition design framework

    Directory of Open Access Journals (Sweden)

    Van Der Merwe, Carmen

    2015-05-01

    Full Text Available Numerous problems with product quality and time-to-market launches can be traced back to how the product lifecycle process is managed within the organisation. This article provides insight into how an integrated value proposition design framework shifts product lifecycle management from a product-centric view to a customer-centric view, through the use of good engineering practices as found in the systems engineering discipline. Combining this with methods and tools such as the Refined Kano model, Blue Ocean strategy, and the Generalised Bass model enables the organisation to enhance product and service quality while reducing the time-to-market for new value proposition launches.

  19. Knowledge engineering in volcanology: Practical claims and general approach

    Science.gov (United States)

    Pshenichny, Cyril A.

    2014-10-01

    Knowledge engineering, being a branch of artificial intelligence, offers a variety of methods for elicitation and structuring of knowledge in a given domain. Only a few of them (ontologies and semantic nets, event/probability trees, Bayesian belief networks and event bushes) are known to volcanologists. Meanwhile, the tasks faced by volcanology and the solutions found so far favor a much wider application of knowledge engineering, especially tools for handling dynamic knowledge. This raises some fundamental logical and mathematical problems and requires an organizational effort, but may strongly improve panel discussions, enhance decision support, optimize physical modeling and support scientific collaboration.

  20. A systems engineering management approach to resource management applications

    Science.gov (United States)

    Hornstein, Rhoda Shaller

    1989-01-01

    The author presents a program management response to the following question: How can the traditional practice of systems engineering management, including requirements specification, be adapted, enhanced, or modified to build future planning and scheduling systems for effective operations? The systems engineering management process, as traditionally practiced, is examined. Extensible resource management systems are discussed. It is concluded that extensible systems are a partial solution to problems presented by requirements that are incomplete, partially immeasurable, and often dynamic. There are positive indications that resource management systems have been characterized and modeled sufficiently to allow their implementation as extensible systems.

  1. Ensuring the Reliable Operation of the Power Grid: State-Based and Distributed Approaches to Scheduling Energy and Contingency Reserves

    Science.gov (United States)

    Prada, Jose Fernando

    Keeping a contingency reserve in power systems is necessary to preserve the security of real-time operations. This work studies two different approaches to the optimal allocation of energy and reserves in the day-ahead generation scheduling process. Part I presents a stochastic security-constrained unit commitment model to co-optimize energy and the locational reserves required to respond to a set of uncertain generation contingencies, using a novel state-based formulation. The model is applied in an offer-based electricity market to allocate contingency reserves throughout the power grid, in order to comply with the N-1 security criterion under transmission congestion. The objective is to minimize expected dispatch and reserve costs, together with post contingency corrective redispatch costs, modeling the probability of generation failure and associated post contingency states. The characteristics of the scheduling problem are exploited to formulate a computationally efficient method, consistent with established operational practices. We simulated the distribution of locational contingency reserves on the IEEE RTS96 system and compared the results with the conventional deterministic method. We found that assigning locational spinning reserves can guarantee an N-1 secure dispatch accounting for transmission congestion at a reasonable extra cost. The simulations also showed little value of allocating downward reserves but sizable operating savings from co-optimizing locational nonspinning reserves. Overall, the results indicate the computational tractability of the proposed method. Part II presents a distributed generation scheduling model to optimally allocate energy and spinning reserves among competing generators in a day-ahead market. The model is based on the coordination between individual generators and a market entity. The proposed method uses forecasting, augmented pricing and locational signals to induce efficient commitment of generators based on firm

  2. An engineering thermodynamic approach to select the electromagnetic wave effective on cell growth.

    Science.gov (United States)

    Lucia, Umberto; Grisolia, Giulia; Ponzetto, Antonio; Silvagno, Francesca

    2017-09-21

    To date, the choice of the characteristics of the extremely low-frequency electromagnetic field beneficial in proliferative disorders is still empirical. In order to make the ELF interaction selective, we applied the thermodynamic and biochemical principles to the analysis of the thermo-chemical output generated by the cell in the environment. The theoretical approach applied an engineering bio-thermodynamic approach recently developed in order to obtain a physical-mathematical model that calculated the frequency of the field able to maximize the mean entropy changes as a function of cellular parameters. The combined biochemical approach envisioned the changes of entropy as a metabolic shift leading to a reduction of cell growth. The proliferation of six human cancer cell lines was evaluated as the output signal able to confirm the correctness of the mathematical model. By considering the cell as a reactive system able to respond to the unbalancing external stimuli, for the first time we could calculate and validate the frequencies of the field specifically effective on distinct cells. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Genome-wide analytical approaches for reverse metabolic engineering of industrially relevant phenotypes in yeast.

    Science.gov (United States)

    Oud, Bart; van Maris, Antonius J A; Daran, Jean-Marc; Pronk, Jack T

    2012-03-01

    Successful reverse engineering of mutants that have been obtained by nontargeted strain improvement has long presented a major challenge in yeast biotechnology. This paper reviews the use of genome-wide approaches for analysis of Saccharomyces cerevisiae strains originating from evolutionary engineering or random mutagenesis. On the basis of an evaluation of the strengths and weaknesses of different methods, we conclude that for the initial identification of relevant genetic changes, whole genome sequencing is superior to other analytical techniques, such as transcriptome, metabolome, proteome, or array-based genome analysis. Key advantages of this technique over gene expression analysis include the independency of genome sequences on experimental context and the possibility to directly and precisely reproduce the identified changes in naive strains. The predictive value of genome-wide analysis of strains with industrially relevant characteristics can be further improved by classical genetics or simultaneous analysis of strains derived from parallel, independent strain improvement lineages. © 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  4. A multi-agent approach to professional software engineering

    NARCIS (Netherlands)

    M. Lützenberger; T. Küster; T. Konnerth; A. Thiele; N. Masuch; A. Heßler; J. Keiser; M. Burkhardt; S. Kaiser (Silvan); J. Tonn; M. Kaisers (Michael); S. Albayrak; M. Cossentino; A. Seghrouchni; M. Winikoff

    2013-01-01

    htmlabstractThe community of agent researchers and engineers has produced a number of interesting and mature results. However, agent technology is still not widely adopted by industrial software developers or software companies - possibly because existing frameworks are infused with academic

  5. The Company Approach to Software Engineering Project Courses

    Science.gov (United States)

    Broman, D.; Sandahl, K.; Abu Baker, M.

    2012-01-01

    Teaching larger software engineering project courses at the end of a computing curriculum is a way for students to learn some aspects of real-world jobs in industry. Such courses, often referred to as capstone courses, are effective for learning how to apply the skills they have acquired in, for example, design, test, and configuration management.…

  6. Object-oriented approach for gas turbine engine simulation

    Science.gov (United States)

    Curlett, Brian P.; Felder, James L.

    1995-01-01

    An object-oriented gas turbine engine simulation program was developed. This program is a prototype for a more complete, commercial grade engine performance program now being proposed as part of the Numerical Propulsion System Simulator (NPSS). This report discusses architectural issues of this complex software system and the lessons learned from developing the prototype code. The prototype code is a fully functional, general purpose engine simulation program, however, only the component models necessary to model a transient compressor test rig have been written. The production system will be capable of steady state and transient modeling of almost any turbine engine configuration. Chief among the architectural considerations for this code was the framework in which the various software modules will interact. These modules include the equation solver, simulation code, data model, event handler, and user interface. Also documented in this report is the component based design of the simulation module and the inter-component communication paradigm. Object class hierarchies for some of the code modules are given.

  7. Prospects and progress in the production of valuable carotenoids: Insights from metabolic engineering, synthetic biology, and computational approaches.

    Science.gov (United States)

    Sankari, Mohan; Rao, Priya Rajendra; Hemachandran, Hridya; Pullela, Phani Kumar; Doss C, George Priya; Tayubi, Iftikhar Aslam; Subramanian, Babu; Gothandam, K M; Singh, Pooja; Ramamoorthy, Siva

    2018-01-20

    Carotenoids are isoprenoid pigments synthesized exclusively by plants and microorganisms and play critical roles in light harvesting, photoprotection, attracting pollinators and phytohormone production. In recent years, carotenoids have been used for their health benefits due to their high antioxidant activity and are extensively utilized in food, pharmaceutical, and nutraceutical industries. Regulation of carotenoid biosynthesis occurs throughout the life cycle of plants, with vibrant changes in composition based on developmental needs and responses to external environmental stimuli. With advancements in metabolic engineering techniques, there has been tremendous progress in the production of industrially valuable secondary metabolites such as carotenoids. Application of metabolic engineering and synthetic biology has become essential for the successful and improved production of carotenoids. Synthetic biology is an emerging discipline; metabolic engineering approaches may provide insights into novel ideas for biosynthetic pathways. In this review, we discuss the current knowledge on carotenoid biosynthetic pathways and genetic engineering of carotenoids to improve their nutritional value. In addition, we investigated synthetic biological approaches for the production of carotenoids. Theoretical biology approaches that may aid in understanding the biological sciences are discussed in this review. A combination of theoretical knowledge and experimental strategies may improve the production of industrially relevant secondary metabolites. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. A New Value Stream Mapping Approach for Engineer-to-Order Production Systems

    OpenAIRE

    Thomassen, Maria,; Alfnes, Erlend; Gran, Erik

    2015-01-01

    Part 5: Operations Management in Engineer-to-Order Manufacturing; International audience; Companies seeking to implement lean practices in engineer-to-order environments experience major difficulties due to a high degree of non-standard products and non-repetitive processes. Current lean methods need to be further developed to be more efficiently applied in manufacturing environments with high variety and complexity. This paper presents a new approach for value stream mapping adapted to engin...

  9. Impact of typhoon disturbance on the diversity of key ecosystem engineers in a monoculture mangrove forest plantation, Can Gio Biosphere Reserve, Vietnam.

    OpenAIRE

    Diele, Karen.; Tran Ngoc, D M.; Geist, S J.; Meyer, F.; Pham, Q H.; Saint-Paul, Ulrich.; Triet, Tran.; Berger, Uta.

    2013-01-01

    Mangrove crabs as key ecosystem engineers may play an important role in the recovery process of storm-damaged forests. Yet, their response to storm disturbance is largely unknown. Here we compare the ground-dwelling brachyuran crab community of intact mangrove stands with that of typhoon gaps having experienced 100% tree mortality. Field work was conducted in two adjacent areas in Can Gio Biosphere Reserve, southern Vietnam. In each area, an 18–20 yr old monoculture Rhizophora apiculata stand...

  10. Maximum-efficiency architectures for steady-flow combustion engines, I: Attractor trajectory optimization approach

    International Nuclear Information System (INIS)

    Ramakrishnan, Sankaran; Edwards, Christopher F.

    2014-01-01

    In this paper, we present a new systematic optimization approach to identify maximum-efficiency architectures for steady-flow combustion engines. Engine architectures are modeled as trajectories in the thermodynamic state space, and the optimal engine architecture is deduced by minimization of total irreversibility over all permissible trajectories that satisfy device constraints. In the past, both parametric and functional minimizations of engine irreversibility have been studied extensively. Our approach combines the functional optimization aspect (i.e., optimization of the process sequence or engine cycle) and the parametric optimization aspect (i.e., optimization of process lengths or parameters in the engine cycle) to identify the maximum-efficiency architecture permitted by physics. The concept central to this approach is that of chemical-equilibrium attractor states in the thermodynamic state space. It enables semi-analytical optimization for reactive engines with no need to model the detailed combustion dynamics. In this study we present the motivation and theoretical details of this method. In Part II of this study, this approach is applied to optimize the class of simple-cycle gas turbine engines. It is shown that even with modest device technology (e.g., turbine inlet temperature of 1650 K), maximum efficiency above 50% can be achieved in simple-cycle engines. - Highlights: • New irreversibility-minimization approach to identify maximum-efficiency architecture for steady-flow combustion engines. • Establishes both the optimal process sequence (engine cycle) and optimal process-length parameters. • Includes minimization of combustion irreversibility

  11. A Constrained and Guided Approach for Managing Software Engineering Course Projects

    Science.gov (United States)

    Cheng, Y.-P.; Lin, J. M.-C.

    2010-01-01

    This paper documents several years of experimentation with a new approach to organizing and managing projects in a software engineering course. The initial failure and subsequent refinements that the new approach has been through since 2004 are described herein. The "constrained and guided" approach, as it is called, has helped to reduce…

  12. Building International Experiences into an Engineering Curriculum--A Design Project-Based Approach

    Science.gov (United States)

    Maldonado, Victor; Castillo, Luciano; Carbajal, Gerardo; Hajela, Prabhat

    2014-01-01

    This paper is a descriptive account of how short-term international and multicultural experiences can be integrated into early design experiences in an aerospace engineering curriculum. Such approaches are considered as important not only in fostering a student's interest in the engineering curriculum, but also exposing them to a multicultural…

  13. An Investigation of First-Year Engineering Student and Instructor Perspectives of Learning Analytics Approaches

    Science.gov (United States)

    Knight, David B.; Brozina, Cory; Novoselich, Brian

    2016-01-01

    This paper investigates how first-year engineering undergraduates and their instructors describe the potential for learning analytics approaches to contribute to student success. Results of qualitative data collection in a first-year engineering course indicated that both students and instructors\temphasized a preference for learning analytics…

  14. A Holistic Approach to Delivering Sustainable Design Education in Civil Engineering

    Science.gov (United States)

    Vemury, Chandra Mouli; Heidrich, Oliver; Thorpe, Neil; Crosbie, Tracey

    2018-01-01

    Purpose: The purpose of this paper is to present pedagogical approaches developed and implemented to deliver sustainable design education (SDE) to second-year undergraduate students on civil engineering programmes in the (then) School of Civil Engineering and Geosciences at Newcastle University. In doing so, the work presented offers an example of…

  15. Scaffolding in tissue engineering: general approaches and tissue-specific considerations.

    Science.gov (United States)

    Chan, B P; Leong, K W

    2008-12-01

    Scaffolds represent important components for tissue engineering. However, researchers often encounter an enormous variety of choices when selecting scaffolds for tissue engineering. This paper aims to review the functions of scaffolds and the major scaffolding approaches as important guidelines for selecting scaffolds and discuss the tissue-specific considerations for scaffolding, using intervertebral disc as an example.

  16. Reflective approach to organizing learning and cognitive activities of engineering students

    OpenAIRE

    GRICHCHINA A.

    2016-01-01

    The role of the reflective approach in higher education is examined in the article. Types of reflection in learning and cognitive activities of engineering students are considered. Reflection as a personal quality of a future engineer is viewed as a powerful tool for the formation of a creative and independent personality.

  17. Approach and strategy for performing ecological risk assessments for the US Department of Energy's Oak Ridge Reservation: 1995 revision

    International Nuclear Information System (INIS)

    Suter, G.W. II; Sample, B.E.; Jones, D.S.; Ashwood, T.L.; Loar, J.M.

    1995-09-01

    The purpose of this document is to provide guidance for planning and performing ecological risk assessments (ERAs) on the Oak Ridge Reservation (ORR). It is the third such document prepared for this purpose. The first ecorisk strategy document described the ERA process and presented a tiered approach to ERAs appropriate to complex sites. The first revision was necessitated by the considerable progress that has been made by the parties to the Federal Facilities Agreement (FFA) for the ORR in resolving specific issues relating to ERA as a result of a series of data quality objectives (DQOs) meetings. The tiered approach to ERAs as recommended in the first document was implemented, generic conceptual models were developed, and a general approach for developing ecological assessment endpoints and measurement endpoints was agreed upon. This revision is necessitated by comments from the US Environmental Protection Agency's Region IV and the Tennessee Department of Environment and Conservation (TDEC) which clarified and modified the positions taken during the DQO process. In particular, support for the collection of data that would support ERAs for all OUs on the ORR have been withdrawn. Therefore, the work plan developed to fill the reservation-wide data needs identified in the DQO process has also been withdrawn, and portions that are still relevant have been incorporated into this document. The reader should be aware that this guidance is complex and lengthy because it attempts to cover all the reasonable contingencies that were considered to be potentially important to the FFA parties

  18. Wildland fire management. Volume 1: Prevention methods and analysis. [systems engineering approach to California fire problems

    Science.gov (United States)

    Weissenberger, S. (Editor)

    1973-01-01

    A systems engineering approach is reported for the problem of reducing the number and severity of California's wildlife fires. Prevention methodologies are reviewed and cost benefit models are developed for making preignition decisions.

  19. Experimental Approach of Fault Movement on an Engineered Barrier System

    International Nuclear Information System (INIS)

    Lee, Minsoo; Choi, Heuijoo; Kim, Heuna

    2012-01-01

    Safety evaluation of an engineered barrier system against fault movement at underground disposal region for high level waste (HLW) is tried using a miniature bore-shear apparatus. For the purpose, a miniature bore-shear apparatus simulating an EBS (engineered barrier system) was manufactured in 1/30 scale. And using the developed apparatus, bore-shear tests were performed twice. During the tests, pressure variations were checked at 6 points around buffer zone, and then a rotational angle of the test vessel was checked. The achieved pressure data were compared with those from analytical modeling, which is based on Drucker-Prager model. At initial shearing step, high pressure was recorded at some point but it decreased rapidly. For the better understanding of fault movement, the modification of an analytical model and the accumulation of experimental experience were required

  20. Experimental Approach of Fault Movement on an Engineered Barrier System

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Minsoo; Choi, Heuijoo; Kim, Heuna [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-03-15

    Safety evaluation of an engineered barrier system against fault movement at underground disposal region for high level waste (HLW) is tried using a miniature bore-shear apparatus. For the purpose, a miniature bore-shear apparatus simulating an EBS (engineered barrier system) was manufactured in 1/30 scale. And using the developed apparatus, bore-shear tests were performed twice. During the tests, pressure variations were checked at 6 points around buffer zone, and then a rotational angle of the test vessel was checked. The achieved pressure data were compared with those from analytical modeling, which is based on Drucker-Prager model. At initial shearing step, high pressure was recorded at some point but it decreased rapidly. For the better understanding of fault movement, the modification of an analytical model and the accumulation of experimental experience were required.

  1. SYSTEMS ENGINEERING APPROACHES FOR IMPROVING REUSABLE MEDICAL EQUIPMENT REPROCESSING PROCESSES

    OpenAIRE

    JAMES C. BENNEYAN; CLAIRE BOND

    2013-01-01

    Hospital reusable medical equipment (RME) includes any items that are intended to be reprocessed and reused indefinitely, including surgical instruments, dental equipment, endoscopes, and others. Such equipment represent a significant portion of a hospital's inventory costs and recently have generated significant patient cross-contamination concerns due to reprocessing cleaning failures. This paper discusses recent applications of industrial and systems engineering (ISyE) methods within healt...

  2. Banding approach for engineered nanomaterial risk assessment and control

    International Nuclear Information System (INIS)

    Van Hoornick, Nausikaä; Prodanov, Dimiter; Pardon, Alain

    2017-01-01

    Since there is a lack of sufficient toxicological information about engineered nanomaterials, and since within the semiconductor research and manufacturing use is already made of these materials, an alternative for the classical quantitative risk assessment was sought. Within the research facilities of imec use is made of a banding technique to determine the risks associated with the nanomaterial research. The method and the measures that are taken are discussed in the paper. The method has been benchmarked with other available techniques. (paper)

  3. Postmortem Reviews: Purpose and Approaches in Software Engineering

    OpenAIRE

    Dingsøyr, Torgeir

    2005-01-01

    Conducting postmortems is a simple and practical method for organisational learning. Yet, not many companies have implemented such practices, and in a survey, few expressed satisfaction with how postmortems were conducted. In this article, we discuss the importance of postmortem reviews as a method for knowledge sharing in software projects, and give an overview of known such processes in the field of software engineering. In particular, we present three lightweight methods for conducting pos...

  4. Applying rock mass classifications to carbonate rocks for engineering purposes with a new approach using the rock engineering system

    Directory of Open Access Journals (Sweden)

    Gioacchino Francesco Andriani

    2017-04-01

    Full Text Available Classical rock mass classification systems are not applicable to carbonate rocks, especially when these are affected by karst processes. Their applications to such settings could therefore result in outcomes not representative of the real stress–strain behavior. In this study, we propose a new classification of carbonate rock masses for engineering purposes, by adapting the rock engineering system (RES method by Hudson for fractured and karstified rock masses, in order to highlight the problems of implementation of geomechanical models to carbonate rocks. This new approach allows a less rigid classification for carbonate rock masses, taking into account the local properties of the outcrops, the site conditions and the type of engineering work as well.

  5. Computer aided approach for qualitative risk assessment of engineered systems

    International Nuclear Information System (INIS)

    Crowley, W.K.; Arendt, J.S.; Fussell, J.B.; Rooney, J.J.; Wagner, D.P.

    1978-01-01

    This paper outlines a computer aided methodology for determining the relative contributions of various subsystems and components to the total risk associated with an engineered system. Major contributors to overall task risk are identified through comparison of an expected frequency density function with an established risk criterion. Contributions that are inconsistently high are also identified. The results from this analysis are useful for directing efforts for improving system safety and performance. An analysis of uranium hexafluoride handling risk at a gaseous diffusion uranium enrichment plant using a preliminary version of the computer program EXCON is briefly described and illustrated

  6. Writing Compilers and Interpreters A Software Engineering Approach

    CERN Document Server

    Mak, Ronald

    2011-01-01

    Long-awaited revision to a unique guide that covers both compilers and interpreters Revised, updated, and now focusing on Java instead of C++, this long-awaited, latest edition of this popular book teaches programmers and software engineering students how to write compilers and interpreters using Java. You?ll write compilers and interpreters as case studies, generating general assembly code for a Java Virtual Machine that takes advantage of the Java Collections Framework to shorten and simplify the code. In addition, coverage includes Java Collections Framework, UML modeling, object-oriented p

  7. Impact of pedagogical approaches on cognitive complexity and motivation to learn: Comparing nursing and engineering undergraduate students.

    Science.gov (United States)

    McComb, Sara A; Kirkpatrick, Jane M

    2016-01-01

    The changing higher education landscape is prompting nurses to rethink educational strategies. Looking beyond traditional professional boundaries may be beneficial. We compare nursing to engineering because engineering has similar accreditation outcome goals and different pedagogical approaches. We compare students' cognitive complexity and motivation to learn to identify opportunities to share pedagogical approaches between nursing and engineering. Cross-sectional data were collected from 1,167 freshmen through super senior students. Comparisons were made across years and between majors. Overall nursing and engineering students advance in cognitive complexity while maintaining motivation for learning. Sophomores reported the lowest scores on many dimensions indicating that their experiences need review. The strong influence of the National Council Licensure Examination on nursing students may drive their classroom preferences. Increased intrinsic motivation, coupled with decreased extrinsic motivation, suggests that we are graduating burgeoning life-long learners equipped to maintain currency. The disciplines' strategies for incorporating real-world learning opportunities differ, yet the students similarly advance in cognitive complexity and maintain motivation to learn. Lessons can be exchanged across professional boundaries. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. The equivalent energy method: an engineering approach to fracture

    International Nuclear Information System (INIS)

    Witt, F.J.

    1981-01-01

    The equivalent energy method for elastic-plastic fracture evaluations was developed around 1970 for determining realistic engineering estimates for the maximum load-displacement or stress-strain conditions for fracture of flawed structures. The basis principles were summarized but the supporting experimental data, most of which were obtained after the method was proposed, have never been collated. This paper restates the original bases more explicitly and presents the validating data in graphical form. Extensive references are given. The volumetric energy ratio, a modelling parameter encompassing both size and temperature, is the fundamental parameter of the equivalent energy method. It is demonstrated that, in an engineering sense, the volumetric energy ratio is a unique material characteristic for a steel, much like a material property except size must be taken into account. With this as a proposition, the basic formula of the equivalent energy method is derived. Sufficient information is presented so that investigators and analysts may judge the viability and applicability of the method to their areas of interest. (author)

  9. A statistical combustion phase control approach of SI engines

    Science.gov (United States)

    Gao, Jinwu; Wu, Yuhu; Shen, Tielong

    2017-02-01

    In order to maximize the performance of internal combustion engine, combustion phase is usually controlled to track its desired reference. However, suffering from the cyclic variability of combustion, it is difficulty but meaningful to control mean of combustion phase and constrain its variance. As a combustion phase indicator, the location of peak pressure (LPP) is utilized for real-time combustion phase control in this research. The purpose of the proposed method is to ensure the mean of LPP statistically tracks its reference and constrains the standard deviation of LPP distribution. To achieve this, LPP is first calculated based on the cylinder pressure sensor, and its characteristics are analyzed at the steady-state operating condition, then the distribution of LPP is examined online using hypothesis test criterion. On the basis of the presented statistical algorithm, current mean of LPP is applied in the feedback channel for designing spark advance adjustment law, and the stability of closed-loop system is theoretically ensured according to a steady statistical model. Finally, the proposed strategy is verified on a spark ignition gasoline engine.

  10. Optical coherence tomography compared with fractional flow reserve guided approach in acute coronary syndromes: A propensity matched analysis.

    Science.gov (United States)

    D'Ascenzo, Fabrizio; Iannaccone, Mario; De Filippo, Ovidio; Leone, Antonio Maria; Niccoli, Giampaolo; Zilio, Filippo; Ugo, Fabrizio; Cerrato, Enrico; Fineschi, Massimo; Mancone, Massimo; Rigattieri, Stefano; Amabile, Nicolas; Ferlini, Marco; Sardella, Gennaro; Cresti, Alberto; Barbero, Umberto; Motreff, Pascal; Colombo, Francesco; Colangelo, Salvatore; Garbo, Roberto; Biondi-Zoccai, Giuseppe; Tamburino, Corrado; Montefusco, Antonio; Omedè, Pierlugi; Moretti, Claudio; D'amico, Maurizio; Souteyrand, Geraud; Gaita, Fiorenzo; Limbruno, Ugo; Picchi, Andrea

    2017-10-01

    To compare in patients with ACS (acute coronary syndromes) a PCI (percutaneous coronary intervention) approach based on FFR (fractional flow reserve) vs. one based on OCT (optical coherence tomography). Consecutive patients admitted for ACS and treated with a PCI approach based on OCT or on FFR (recruited in two different studies) were compared and matched with propensity score analysis. Target Lesion revascularization (TLR) was the primary end point, while major adverse cardiovascular events [MACEs defined as the composite of death from cardiac causes, non-fatal MI, clinically driven target vessel revascularization (TVR), or re-hospitalization due to unstable angina] were the secondary ones. Sub-group analysis was performed for patients with FFR/OCT performed on culprit lesions and not. 285 patients were enrolled in the OCT-guided group and 335 in the FFR-guided group, 197 for each being selected after propensity score. After 25months (range: 7-39months), OCT-guided group were exposed to lower incidence of TLR (4.1% vs. 14.2% p<0.01) compared with FFR-guided group without impact on MACEs (14.2% vs. 14.2%, p=1) or all-cause death (3.6% vs. 1.1%, p=0.34). At Kaplan-Maier curve analysis for MACEs OCT-guided and FFR-guided groups showed similar outcomes (HR 1.19, CI 0.65-2.2, p=0.54). Subgroup analysis on culprit and not culprit vessel demonstrated consistent results. An OCT based approach in ACS patients offers a reduction in TLR when compared to a PCI-FFR driven. These findings should be confirmed in randomized controlled trial. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Application of Systems Engineering to U.S. Department of Energy Privatization Project Selection at the Hanford Nuclear Reservation

    International Nuclear Information System (INIS)

    Layman, John Scott

    1999-01-01

    The privatization efforts at the U.S. Department of Energy's Hanford Nuclear Reservation have been very successful primarily due to a disciplined process for project selection and execution. Early in the development of Privatization at Hanford, the Department of Energy determined that a disciplined alternatives generation and analysis (AGA) process would furnish the candidate projects with the best probability for success. Many factors had to be considered in the selection of projects. Westinghouse Hanford Company was assigned to develop this process and facilitate the selection of the first round of candidate privatization projects. Team members for the AGA process were assembled from all concerned organizations and skill groups. Among the selection criteria were legal, financial and technical considerations which had to be weighed

  12. Multiobjective engineering design optimization problems: a sensitivity analysis approach

    Directory of Open Access Journals (Sweden)

    Oscar Brito Augusto

    2012-12-01

    Full Text Available This paper proposes two new approaches for the sensitivity analysis of multiobjective design optimization problems whose performance functions are highly susceptible to small variations in the design variables and/or design environment parameters. In both methods, the less sensitive design alternatives are preferred over others during the multiobjective optimization process. While taking the first approach, the designer chooses the design variable and/or parameter that causes uncertainties. The designer then associates a robustness index with each design alternative and adds each index as an objective function in the optimization problem. For the second approach, the designer must know, a priori, the interval of variation in the design variables or in the design environment parameters, because the designer will be accepting the interval of variation in the objective functions. The second method does not require any law of probability distribution of uncontrollable variations. Finally, the authors give two illustrative examples to highlight the contributions of the paper.

  13. Encouraging Deep Approach to Learning in Civil and Geodetic Engineering

    Directory of Open Access Journals (Sweden)

    Gašper Mrak

    2016-10-01

    Full Text Available This paper presents activities and changes applied to the teaching process within selected courses offered by Faculty of civil and geodetic engineering, University of Ljubljana, Slovenia. Theoretical background, evaluated from the point of the technical education needs, is presented. It can be seen that special focus has to be made to the students' motivation for deep learning which guarantees optimal balance between acquisition of concepts and skills, information processing and integration of fragmented pieces of knowledge into complex structures. Three case studies used to test theoretical points of departure are presented. Results of the introduced novelties and changes have been evaluated through the assessment of knowledge, students' satisfaction and teaching staff evaluations. For conclusive results, monitoring over a longer period of time should be conducted.

  14. A Theoretical Approach to Engineering a New Enzyme

    International Nuclear Information System (INIS)

    Anderson, Greg; Gomatam, Ravi; Behera, Raghu N.

    2016-01-01

    Density function theory, a subfield of quantum mechanics (QM), in combination with molecular mechanics (MM) has opened the way to engineer new artificial enzymes. Herein, we report theoretical calculations done using QM/MM to examine whether the regioselectivity and rate of chlorination of the enzyme chloroperoxidase can be improved by replacing the vanadium of this enzyme with niobium through dialysis. Our calculations show that a niobium substituted chloroperoxidase will be able to enter the initial steps of the catalytic cycle for chlorination. Although the protonation state of the niobium substituted enzyme is calculated to be different from than that of the natural vanadium substituted enzyme, our calculations show that the catalytic cycle can still proceed forward. Using natural bond orbitals, we analyse the electronic differences between the niobium substituted enzyme and the natural enzyme. We conclude by briefly examining how good of a model QM/MM provides for understanding the mechanism of catalysis of chloroperoxidase. (paper)

  15. Reverse breeding: a novel breeding approach based on engineered meiosis.

    Science.gov (United States)

    Dirks, Rob; van Dun, Kees; de Snoo, C Bastiaan; van den Berg, Mark; Lelivelt, Cilia L C; Voermans, William; Woudenberg, Leo; de Wit, Jack P C; Reinink, Kees; Schut, Johan W; van der Zeeuw, Eveline; Vogelaar, Aat; Freymark, Gerald; Gutteling, Evert W; Keppel, Marina N; van Drongelen, Paul; Kieny, Matthieu; Ellul, Philippe; Touraev, Alisher; Ma, Hong; de Jong, Hans; Wijnker, Erik

    2009-12-01

    Reverse breeding (RB) is a novel plant breeding technique designed to directly produce parental lines for any heterozygous plant, one of the most sought after goals in plant breeding. RB generates perfectly complementing homozygous parental lines through engineered meiosis. The method is based on reducing genetic recombination in the selected heterozygote by eliminating meiotic crossing over. Male or female spores obtained from such plants contain combinations of non-recombinant parental chromosomes which can be cultured in vitro to generate homozygous doubled haploid plants (DHs). From these DHs, complementary parents can be selected and used to reconstitute the heterozygote in perpetuity. Since the fixation of unknown heterozygous genotypes is impossible in traditional plant breeding, RB could fundamentally change future plant breeding. In this review, we discuss various other applications of RB, including breeding per chromosome.

  16. A new approach to heart valve tissue engineering

    DEFF Research Database (Denmark)

    Kaasi, Andreas; Cestari, Idágene A.; Stolf, Noedir A G.

    2011-01-01

    the cell-scaffold constructs to a wider array of mechanical forces. The pump of the VAD has two chambers: a blood and a pneumatic chamber, separated by an elastic membrane. Pulsatile air-pressure is generated by a piston-type actuator and delivered to the pneumatic chamber, ejecting the fluid in the blood...... chamber. Subsequently, applied vacuum to the pneumatic chamber causes the blood chamber to fill. A mechanical heart valve was placed in the VAD's inflow position. The tissue engineered (TE) valve was placed in the outflow position. The VAD was coupled in series with a Windkessel compliance chamber......, variable throttle and reservoir, connected by silicone tubings. The reservoir sat on an elevated platform, allowing adjustment of ventricular preload between 0 and 11 mmHg. To allow for sterile gaseous exchange between the circuit interior and exterior, a 0.2 µm filter was placed at the reservoir. Pressure...

  17. Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry

    Directory of Open Access Journals (Sweden)

    Maurizio Bossù

    2014-01-01

    Full Text Available In dental practice there is an increasing need for predictable therapeutic protocols able to regenerate tissues that, due to inflammatory or traumatic events, may suffer from loss of their function. One of the topics arising major interest in the research applied to regenerative medicine is represented by tissue engineering and, in particular, by stem cells. The study of stem cells in dentistry over the years has shown an exponential increase in literature. Adult mesenchymal stem cells have recently been isolated and characterized from tooth-related tissues and they might represent, in the near future, a new gold standard in the regeneration of all oral tissues. The aim of our review is to provide an overview on the topic reporting the current knowledge for each class of dental stem cells and to identify their potential clinical applications as therapeutic tool in various branches of dentistry.

  18. Building habitats on the Moon engineering approaches to lunar settlements

    CERN Document Server

    Benaroya, Haym

    2018-01-01

    Designing a habitat for the lunar surface? You will need to know more than structural engineering. There are the effects of meteoroids, radiation, and low gravity. Then there are the psychological and psychosocial aspects of living in close quarters, in a dangerous environment, far away from home. All these must be considered when the habitat is sized, materials specified, and structure designed. This book provides an overview of various concepts for lunar habitats and structural designs and characterizes the lunar environment - the technical and the nontechnical. The designs take into consideration psychological comfort, structural strength against seismic and thermal activity, as well as internal pressurization and 1/6 g. Also discussed are micrometeoroid modeling, risk and redundancy as well as probability and reliability, with an introduction to analytical tools that can be useful in modeling uncertainties.

  19. A Blended Learning Approach to Teach Fluid Mechanics in Engineering

    Science.gov (United States)

    Rahman, Ataur

    2017-01-01

    This paper presents a case study on the teaching and learning of fluid mechanics at the University of Western Sydney (UWS), Australia, by applying a blended learning approach (BLA). In the adopted BLA, various flexible learning materials have been made available to the students such as online recorded lectures, online recorded tutorials, hand…

  20. Safety Concepts in Structural Glass Engineering : Towards an Integrated Approach

    NARCIS (Netherlands)

    Bos, F.P.

    2009-01-01

    This dissertation proposes the Integrated Approach to Structural Glass Safety, based on four clearly defined element safety properties, damage sensitivity, relative resistance, redundancy, and fracture mode. The Element Safety Diagram (ESD) is introduced to provide an easy-to-read graphical

  1. Towards modeling future energy infrastructures - the ELECTRA system engineering approach

    DEFF Research Database (Denmark)

    Uslar, Mathias; Heussen, Kai

    2016-01-01

    of the IEC 62559 use case template as well as needed changes to cope particularly with the aspects of controller conflicts and Greenfield technology modeling. From the original envisioned use of the standards, we show a possible transfer on how to properly deal with a Greenfield approach when modeling....

  2. A Planning Approach of Engineering Characteristics Based on QFD-TRIZ Integrated

    Science.gov (United States)

    Liu, Shang; Shi, Dongyan; Zhang, Ying

    Traditional QFD planning method compromises contradictions between engineering characteristics to achieve higher customer satisfaction. However, this compromise trade-off can not eliminate the contradictions existing among the engineering characteristics which limited the overall customer satisfaction. QFD (Quality function deployment) integrated with TRIZ (the Russian acronym of the Theory of Inventive Problem Solving) becomes hot research recently for TRIZ can be used to solve contradictions between engineering characteristics which construct the roof of HOQ (House of quality). But, the traditional QFD planning approach is not suitable for QFD integrated with TRIZ for that TRIZ requires emphasizing the contradictions between engineering characteristics at problem definition stage instead of compromising trade-off. So, a new planning approach based on QFD / TRIZ integration is proposed in this paper, which based on the consideration of the correlation matrix of engineering characteristics and customer satisfaction on the basis of cost. The proposed approach suggests that TRIZ should be applied to solve contradictions at the first step, and the correlation matrix of engineering characteristics should be amended at the second step, and at next step IFR (ideal final result) must be validated, then planning execute. An example is used to illustrate the proposed approach. The application indicated that higher customer satisfaction can be met and the contradictions between the characteristic parameters are eliminated.

  3. The dynamic of urban and protected areas at Balai Raja Wildlife Reserve, Riau, Indonesia: a social ecology approach

    Science.gov (United States)

    Suwondo; Darmadi; Yunus, M.

    2018-01-01

    The development process has resulted in deforestation. A comprehensive study is needed to obtain an objective solution by integrating the ecological dimension and human dimension. This study was conducted within Balai Raja Wildlife Reserve (BRWR), Bengkalis Regency, Riau Province, Indonesia. We used the social-ecological systems (SES) approach based on local characteristics, categorized into ecological status, social status and actors. Each factoris ranked using Multi-Dimensional Scaling (MDS).BRWR sustainability levels are in moderate condition. The ecological dimension is in a less sustainable state, with leverage: (1) forest conversion; (2) local ecological knowledge; (3) high conservation value. The social dimension is in a less sustainable state, with leverage: (1) community empowerment; (2) social conflict; (3) participation in landscape management. Dimensions actors are on a fairly sustainable status, with leverage: (1) institutional interaction; (2) stakeholder’s commitment; (3) law enforcement. We recommend strengthening community empowerment, local ecological knowledge, interaction, and stakeholder commitment

  4. An engineering approach to common mode failure analysis

    International Nuclear Information System (INIS)

    Gangloff, W.C.; Franke, T.H.

    1975-01-01

    Safety systems for nuclear reactors can be designed using standard reliability engineering techniques such that system failure due to random component faults is extremely unlikely. However, the common-mode failure where several components fail together from a common cause is not susceptible to prevention by the usual tactics. In systems where a high degree of redundancy has been employed, the actual reliability of the system in service may be limited by common-mode failures. A methodical and thorough procedure for evaluation of system vulnerability to common-mode failures is presented. This procedure was developed for use in nuclear reactor safety systems and has been applied specifically to reactor protection. The method offers a qualitative assessment of a system whereby weak points can be identified and the resistance to common-mode failure can be judged. It takes into account all factors influencing system performance including design, manufacturing, installation, operation, testing, and maintenance. It is not a guarantee or sure solution, but rather a practical tool which can provide good assurance that the probability of common-mode protection failure has been made acceptably low. (author)

  5. A Resilience Engineering Approach for Sustainable Safety in Green Construction

    Directory of Open Access Journals (Sweden)

    Lucio V. Rosa

    2017-12-01

    Full Text Available Sustainable construction is a complex endeavour, involving various stakeholders and resulting in situations that are incompletely described or underspecified. Traditional risk assessment methods require a detailed description of the system and safety, focusing on undesirable outcomes, losses, incidents and accidents. Developing this principle, this research describes a new way to deal with risk assessment in the green construction industry using a resilience engineering method based on the functional resonanceanalysis method and analytic hierarchy process methodologies. The functional resonance analysis method defines a systemic framework to model complex systems based on combinations of function variabilities during normal work. Therefore, to quantify the outcomes for risk assessment, this method was used together with the analytic hierarchy process in a case study during the modernisation work on the Maracanã stadium in Rio de Janeiro. The results of this case study demonstrate that the combined utilisation of the functional resonance analysis method and analytic hierarchy process can be utilised to recognise situations where developments could potentially be without control, which enables this to be used as a basis for performing indicators or a monitoring system. Furthermore, this combined technique can be used to assess and quantify the performance variabilities that may lead to occupational or environmental accidents, and provide new recommendations about how work processes should function, minimising production losses, incidents and accidents.

  6. Nonlinear approaches in engineering applications applied mechanics, vibration control, and numerical analysis

    CERN Document Server

    Jazar, Reza

    2015-01-01

    This book focuses on the latest applications of nonlinear approaches in different disciplines of engineering. For each selected topic, detailed concept development, derivations, and relevant knowledge are provided for the convenience of the readers. The topics range from dynamic systems and control to optimal approaches in nonlinear dynamics. The volume includes invited chapters from world class experts in the field. The selected topics are of great interest in the fields of engineering and physics and this book is ideal for engineers and researchers working in a broad range of practical topics and approaches. This book also: ·         Explores the most up-to-date applications and underlying principles of nonlinear approaches to problems in engineering and physics, including sections on analytic nonlinearity and practical nonlinearity ·         Enlightens readers to the conceptual significance of nonlinear approaches with examples of applications in scientific and engineering problems from v...

  7. Nonlinear approaches in engineering applications advanced analysis of vehicle related technologies

    CERN Document Server

    Dai, Liming

    2016-01-01

    This book looks at the broad field of engineering science through the lens of nonlinear approaches. Examples focus on issues in vehicle technology, including vehicle dynamics, vehicle-road interaction, steering, and control for electric and hybrid vehicles. Also included are discussions on train and tram systems, aerial vehicles, robot-human interaction, and contact and scratch analysis at the micro/nanoscale. Chapters are based on invited contributions from world-class experts in the field who advance the future of engineering by discussing the development of more optimal, accurate, efficient, and cost and energy effective systems. This book is appropriate for researchers, students, and practicing engineers who are interested in the applications of nonlinear approaches to solving engineering and science problems.

  8. Semiconductor laser engineering, reliability and diagnostics a practical approach to high power and single mode devices

    CERN Document Server

    Epperlein, Peter W

    2013-01-01

    This reference book provides a fully integrated novel approach to the development of high-power, single-transverse mode, edge-emitting diode lasers by addressing the complementary topics of device engineering, reliability engineering and device diagnostics in the same book, and thus closes the gap in the current book literature. Diode laser fundamentals are discussed, followed by an elaborate discussion of problem-oriented design guidelines and techniques, and by a systematic treatment of the origins of laser degradation and a thorough exploration of the engineering means to enhance the optical strength of the laser. Stability criteria of critical laser characteristics and key laser robustness factors are discussed along with clear design considerations in the context of reliability engineering approaches and models, and typical programs for reliability tests and laser product qualifications. Novel, advanced diagnostic methods are reviewed to discuss, for the first time in detail in book literature, performa...

  9. Tissue engineering approaches for bone repair: concepts and evidence.

    Science.gov (United States)

    Schroeder, Josh E; Mosheiff, Rami

    2011-06-01

    Over the last decades, the medical world has advanced dramatically in the understanding of fracture repair. The three components needed for fracture healing are osteoconduction, osteoinduction and osteogenesis. With newly designed scaffolds, ex vivo produced growth factors and isolated stem cells, most of the challenges of critical size bone defects have been resolved in vitro, and in some cases in animal models as well. However, there are still challenges needed to be overcome before these technologies can be fully converted from the bench to the bedside. These technological and biological advancements need to be converted to mass production of affordable products that can be used in every part of the world. Vascularity, full substation of scaffolds by native bone, and bio-safety are the three most critical steps to be challenged before reaching the clinical setting. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Comparison of different discriminant functions for mangrove species analysis in Matang Mangrove Forest Reserve (MMFR), Perak based on statistical approach

    Science.gov (United States)

    Beh, Boon Chun; Tan, Kok Chooi; Mat Jafri, Mohd. Zubir; Lim, Hwee San

    2017-10-01

    Mangroves are known as salt-tolerant evergreen forests, whereas its create land-ocean interface ecosystems. Besides, mangroves bring direct and indirect benefits to human activities and play a major role as significant habitat for sustaining biodiversity. However, mangrove ecosystem study based on the mangrove species are very crucial to get a better understanding of their characteristics and ways to separate among them. In this paper, discriminant functions obtained using statistical approach were used to generate the score range for six mangrove species (Rhizophora apiculata, Acrostichum aurem, Acrostichum speciosum, Acanthus ilicifolius, Ceriops tagal and Sonneratia ovata) in Matang Mangrove Forest Reserve (MMFR), Perak. With the computation of score range for each species, the fraction of the species can be determined using the proposed algorithm. The results indicate that by using 11 discriminant functions out of 16 are more effective to separate the mangrove species as the higher accuracy was obtained. Overall, the determination of leaf sample's species is chosen base on the highest fraction measured among the six mangrove species. The obtained accuracy for mangrove species using statistical approach is low since it is impossible to successfully separate all the mangrove species in leaf level using their inherent reflectance properties. However, the obtained accuracy results are satisfactory and able to discriminate the examined mangrove species at species scale.

  11. A Value-Based Business Approach to Product Line Software Engineering

    OpenAIRE

    Raman K. Agrawalla

    2009-01-01

    The present conceptual paper is an attempt to provide a Value-Based Business Approach (VBBA) to product line software engineering. It argues that Product line software engineering should be seen as a system and considered as a means towards the end of appropriating more and more value for the business firm; contingent upon the fact that it provides value to customer and customer's customers operating its value creating system with agility, speed, economy and innovation; getting governed by th...

  12. An Agent Based Approach To Finding Expertise In The Engineering Design Environment

    OpenAIRE

    Crowder, Richard; Hughes, Gareth; Hall, Wendy

    2003-01-01

    During the engineering design process people need to locate colleagues with knowledge to resolve a problem. As identified by discussions with practicing designers the use of computer based systems that assist users with finding such expertise will become increasingly important. In this paper we discuss the development of an agent based Expertise Finder suitable for use within an engineering design environment. A key feature of our approach is that the Expertise Finder returns both recommended...

  13. Alternative approach to automated management of load flow in engineering networks considering functional reliability

    Directory of Open Access Journals (Sweden)

    Ирина Александровна Гавриленко

    2016-02-01

    Full Text Available The approach to automated management of load flow in engineering networks considering functional reliability was proposed in the article. The improvement of the concept of operational and strategic management of load flow in engineering networks was considered. The verbal statement of the problem for thesis research is defined, namely, the problem of development of information technology for exact calculation of the functional reliability of the network, or the risk of short delivery of purpose-oriented product for consumers

  14. Omics Approaches for the Engineering of Pathogen Resistant Plants.

    Science.gov (United States)

    Gomez-Casati, Diego F; Pagani, María A; Busi, María V; Bhadauria, Vijai

    2016-01-01

    The attack of different pathogens, such as bacteria, fungi and viruses has a negative impact on crop production. In counter such attacks, plants have developed different strategies involving the modification of gene expression, activation of several metabolic pathways and post-translational modification of proteins, which culminate into the accumulation of primary and secondary metabolites implicated in plant defense responses. The recent advancement in omics techniques allows the increase coverage of plants transcriptomes, proteomes and metabolomes during pathogen attack, and the modulation of the response after the infection. Omics techniques also allow us to learn more about the biological cycle of the pathogens in addition to the identification of novel virulence factors in pathogens and their host targets. Both approaches become important to decipher the mechanism underlying pathogen attacks and to develop strategies for improving disease-resistant plants. In this review, we summarize some of the contribution of genomics, transcriptomics, proteomics, metabolomics and metallomics in devising the strategies to obtain plants with increased resistance to pathogens. These approaches constitute important research tools in the development of new technologies for the protection against diseases and increase plant production.

  15. Environmental Engineering Approaches toward Sustainable Management of Spider Mites.

    Science.gov (United States)

    Suzuki, Takeshi

    2012-10-26

    Integrated pest management (IPM), which combines physical, biological, and chemical control measures to complementary effect, is one of the most important approaches to environmentally friendly sustainable agriculture. To expand IPM, we need to develop new pest control measures, reinforce existing measures, and investigate interactions between measures. Continued progress in the development of environmental control technologies and consequent price drops have facilitated their integration into plant production and pest control. Here I describe environmental control technologies for the IPM of spider mites through: (1) the disturbance of photoperiod-dependent diapause by artificial light, which may lead to death in seasonal environments; (2) the use of ultraviolet radiation to kill or repel mites; and (3) the use of water vapor control for the long-term cold storage of commercially available natural enemies. Such environmental control technologies have great potential for the efficient control of spider mites through direct physical effects and indirect effects via natural enemies.

  16. An Iterative and Incremental Approach for E-Learning Ontology Engineering

    Directory of Open Access Journals (Sweden)

    Sudath Rohitha Heiyanthuduwage

    2009-03-01

    Full Text Available Abstract - There is a boost in the interest on ontology with the developments in Semantic Web technologies. Ontologies play a vital role in semantic web. Even though there is lot of work done on ontology, still a standard framework for ontology engineering has not been defined. Even though current ontology engineering methodologies are available they need improvements. The effort of our work is to integrate various methods, techniques, tools and etc to different stages of proposed ontology engineering life cycle to create a comprehensive framework for ontology engineering. Current methodologies discuss ontology engineering stages and collaborative environments with user collaboration. However, discussion on increasing effectiveness and correct inference has been given less attention. More over, these methodologies provide little discussion on usability of domain ontologies. We consider these aspects as more important in our work. Also, ontology engineering has been done for various domains and for various purposes. Our effort is to propose an iterative and incremental approach for ontology engineering especially for e-learning domain with the intention of achieving a higher usability and effectiveness of e-learning systems. This paper introduces different aspects of the proposed ontology engineering framework and evaluation of it.

  17. Coral reefs for coastal protection: A new methodological approach and engineering case study in Grenada.

    Science.gov (United States)

    Reguero, Borja G; Beck, Michael W; Agostini, Vera N; Kramer, Philip; Hancock, Boze

    2018-03-15

    Coastal communities in tropical environments are at increasing risk from both environmental degradation and climate change and require urgent local adaptation action. Evidences show coral reefs play a critical role in wave attenuation but relatively little direct connection has been drawn between these effects and impacts on shorelines. Reefs are rarely assessed for their coastal protection service and thus not managed for their infrastructure benefits, while widespread damage and degradation continues. This paper presents a systematic approach to assess the protective role of coral reefs and to examine solutions based on the reef's influence on wave propagation patterns. Portions of the shoreline of Grenville Bay, Grenada, have seen acute shoreline erosion and coastal flooding. This paper (i) analyzes the historical changes in the shoreline and the local marine, (ii) assess the role of coral reefs in shoreline positioning through a shoreline equilibrium model first applied to coral reef environments, and (iii) design and begin implementation of a reef-based solution to reduce erosion and flooding. Coastline changes in the bay over the past 6 decades are analyzed from bathymetry and benthic surveys, historical imagery, historical wave and sea level data and modeling of wave dynamics. The analysis shows that, at present, the healthy and well-developed coral reefs system in the southern bay keeps the shoreline in equilibrium and stable, whereas reef degradation in the northern bay is linked with severe coastal erosion. A comparison of wave energy modeling for past bathymetry indicates that degradation of the coral reefs better explains erosion than changes in climate and historical sea level rise. Using this knowledge on how reefs affect the hydrodynamics, a reef restoration solution is designed and studied to ameliorate the coastal erosion and flooding. A characteristic design provides a modular design that can meet specific engineering, ecological and

  18. Integrated approaches to spatiotemporally directing angiogenesis in host and engineered tissues.

    Science.gov (United States)

    Kant, Rajeev J; Coulombe, Kareen L K

    2018-03-15

    engineering for the greater regenerative medicine community. Copyright © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  19. Orion Flight Test 1 Architecture: Observed Benefits of a Model Based Engineering Approach

    Science.gov (United States)

    Simpson, Kimberly A.; Sindiy, Oleg V.; McVittie, Thomas I.

    2012-01-01

    This paper details how a NASA-led team is using a model-based systems engineering approach to capture, analyze and communicate the end-to-end information system architecture supporting the first unmanned orbital flight of the Orion Multi-Purpose Crew Exploration Vehicle. Along with a brief overview of the approach and its products, the paper focuses on the observed program-level benefits, challenges, and lessons learned; all of which may be applied to improve system engineering tasks for characteristically similarly challenges

  20. Harnessing systems biology approaches to engineer functional microvascular networks.

    Science.gov (United States)

    Sefcik, Lauren S; Wilson, Jennifer L; Papin, Jason A; Botchwey, Edward A

    2010-06-01

    Microvascular remodeling is a complex process that includes many cell types and molecular signals. Despite a continued growth in the understanding of signaling pathways involved in the formation and maturation of new blood vessels, approximately half of all compounds entering clinical trials will fail, resulting in the loss of much time, money, and resources. Most pro-angiogenic clinical trials to date have focused on increasing neovascularization via the delivery of a single growth factor or gene. Alternatively, a focus on the concerted regulation of whole networks of genes may lead to greater insight into the underlying physiology since the coordinated response is greater than the sum of its parts. Systems biology offers a comprehensive network view of the processes of angiogenesis and arteriogenesis that might enable the prediction of drug targets and whether or not activation of the targets elicits the desired outcome. Systems biology integrates complex biological data from a variety of experimental sources (-omics) and analyzes how the interactions of the system components can give rise to the function and behavior of that system. This review focuses on how systems biology approaches have been applied to microvascular growth and remodeling, and how network analysis tools can be utilized to aid novel pro-angiogenic drug discovery.

  1. [An object-oriented intelligent engineering design approach for lake pollution control].

    Science.gov (United States)

    Zou, Rui; Zhou, Jing; Liu, Yong; Zhu, Xiang; Zhao, Lei; Yang, Ping-Jian; Guo, Huai-Cheng

    2013-03-01

    Regarding the shortage and deficiency of traditional lake pollution control engineering techniques, a new lake pollution control engineering approach was proposed in this study, based on object-oriented intelligent design (OOID) from the perspective of intelligence. It can provide a new methodology and framework for effectively controlling lake pollution and improving water quality. The differences between the traditional engineering techniques and the OOID approach were compared. The key points for OOID were described as object perspective, cause and effect foundation, set points into surface, and temporal and spatial optimization. The blue algae control in lake was taken as an example in this study. The effect of algae control and water quality improvement were analyzed in details from the perspective of object-oriented intelligent design based on two engineering techniques (vertical hydrodynamic mixer and pumping algaecide recharge). The modeling results showed that the traditional engineering design paradigm cannot provide scientific and effective guidance for engineering design and decision-making regarding lake pollution. Intelligent design approach is based on the object perspective and quantitative causal analysis in this case. This approach identified that the efficiency of mixers was much higher than pumps in achieving the goal of low to moderate water quality improvement. However, when the objective of water quality exceeded a certain value (such as the control objective of peak Chla concentration exceeded 100 microg x L(-1) in this experimental water), the mixer cannot achieve this goal. The pump technique can achieve the goal but with higher cost. The efficiency of combining the two techniques was higher than using one of the two techniques alone. Moreover, the quantitative scale control of the two engineering techniques has a significant impact on the actual project benefits and costs.

  2. Five Years of Designing Wireless Sensor Networks in the Doñana Biological Reserve (Spain): An Applications Approach

    Science.gov (United States)

    Larios, Diego F.; Barbancho, Julio; Sevillano, José L.; Rodríguez, Gustavo; Molina, Francisco J.; Gasull, Virginia G.; Mora-Merchan, Javier M.; León, Carlos

    2013-01-01

    Wireless Sensor Networks (WSNs) are a technology that is becoming very popular for many applications, and environmental monitoring is one of its most important application areas. This technology solves the lack of flexibility of wired sensor installations and, at the same time, reduces the deployment costs. To demonstrate the advantages of WSN technology, for the last five years we have been deploying some prototypes in the Doñana Biological Reserve, which is an important protected area in Southern Spain. These prototypes not only evaluate the technology, but also solve some of the monitoring problems that have been raised by biologists working in Doñana. This paper presents a review of the work that has been developed during these five years. Here, we demonstrate the enormous potential of using machine learning in wireless sensor networks for environmental and animal monitoring because this approach increases the amount of useful information and reduces the effort that is required by biologists in an environmental monitoring task. PMID:24025554

  3. Engineering-derived approaches for iPSC preparation, expansion, differentiation and applications.

    Science.gov (United States)

    Li, Yang; Li, Ling; Chen, Zhi-Nan; Gao, Ge; Yao, Rui; Sun, Wei

    2017-07-31

    Remarkable achievements have been made since induced pluripotent stem cells (iPSCs) were first introduced in 2006. Compared with non-pluripotent stem cells, iPSC research faces several additional complexities, such as the choice of extracellular matrix proteins, growth and differentiation factors, as well as technical challenges related to self-renewal and directed differentiation. Overcoming these challenges requires the integration of knowledge and technologies from multiple fields including cell biology, biomaterial science, engineering, physics and medicine. Here, engineering-derived iPSC approaches are reviewed according to three aspects of iPSC studies: preparation, expansion, differentiation and applications. Engineering strategies, such as 3D systems establishment, cell-matrix mechanics and the regulation of biophysical and biochemical cues, together with engineering techniques, such as 3D scaffolds, cell microspheres and bioreactors, have been applied to iPSC studies and have generated insightful results and even mini-organs such as retinas, livers and intestines. Specific results are given to demonstrate how these approaches impact iPSC behavior, and related mechanisms are discussed. In addition, cell printing technologies are presented as an advanced engineering-derived approach since they have been applied in both iPSC studies and the construction of diverse tissues and organs. Further development and possible innovations of cell printing technologies are presented in terms of creating complex and functional iPSC-derived living tissues and organs.

  4. Experimental study on distributed optical fiber-based approach monitoring saturation line in levee engineering

    Science.gov (United States)

    Su, Huaizhi; Li, Hao; Kang, Yeyuan; Wen, Zhiping

    2018-02-01

    Seepage is one of key factors which affect the levee engineering safety. The seepage danger without timely detection and rapid response may likely lead to severe accidents such as seepage failure, slope instability, and even levee break. More than 90 percent of levee break events are caused by the seepage. It is very important for seepage behavior identification to determine accurately saturation line in levee engineering. Furthermore, the location of saturation line has a major impact on slope stability in levee engineering. Considering the structure characteristics and service condition of levee engineering, the distributed optical fiber sensing technology is introduced to implement the real-time observation of saturation line in levee engineering. The distributed optical fiber temperature sensor system (DTS)-based monitoring principle of saturation line in levee engineering is investigated. An experimental platform, which consists of DTS, heating system, water-supply system, auxiliary analysis system and levee model, is designed and constructed. The monitoring experiment of saturation line in levee model is implemented on this platform. According to the experimental results, the numerical relationship between moisture content and thermal conductivity in porous medium is identified. A line heat source-based distributed optical fiber method obtaining the thermal conductivity in porous medium is developed. A DTS-based approach is proposed to monitor the saturation line in levee engineering. The embedment pattern of optical fiber for monitoring saturation line is presented.

  5. Knowledge management through the e-learning approach - a case study of online engineering courses

    Science.gov (United States)

    Aichouni, Mohamed; Benchicou, Soraya; Nehari, Dris

    2013-06-01

    Though it is universally accepted that the face-to-face approach is the best way for education and training, however, with the advent of the information and communication technologies (mainly the World Wide Web) it became possible to enhance further the methods we are using to teach our students and to share the teaching material within a broaden engineering, technical and business communities. This paper is dedicated to making a review of the basic concepts of knowledge management and e-learning and to show how these two modern concepts can be integrated into engineering education to produce knowledge, disseminate it and share it within virtual interest groups and networks of engineering students, academic teachers and industrial engineers and technicians and business managers. A practical case study will be presented and discussed.

  6. Optimizing Online Suicide Prevention: A Search Engine-Based Tailored Approach.

    Science.gov (United States)

    Arendt, Florian; Scherr, Sebastian

    2017-11-01

    Search engines are increasingly used to seek suicide-related information online, which can serve both harmful and helpful purposes. Google acknowledges this fact and presents a suicide-prevention result for particular search terms. Unfortunately, the result is only presented to a limited number of visitors. Hence, Google is missing the opportunity to provide help to vulnerable people. We propose a two-step approach to a tailored optimization: First, research will identify the risk factors. Second, search engines will reweight algorithms according to the risk factors. In this study, we show that the query share of the search term "poisoning" on Google shows substantial peaks corresponding to peaks in actual suicidal behavior. Accordingly, thresholds for showing the suicide-prevention result should be set to the lowest levels during the spring, on Sundays and Mondays, on New Year's Day, and on Saturdays following Thanksgiving. Search engines can help to save lives globally by utilizing a more tailored approach to suicide prevention.

  7. A Story-Telling Approach for a Software Engineering Course Design

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    2009-01-01

    Advanced programming and software engineering techniques are challenging to learn due to their inherent complexity. However, to the average student they are even more challenging because they have never experienced the context in which the techniques are appropriate. For instance, why learn design...... patterns to increase maintainability when student exercises are never maintained? In this paper, we outline the contextual problems that software engineering teaching has to deal with and present a story telling approach for course design as a remedy. We outline the stories that over the last five years...... have structured lecturing and mandatory exercises for our advanced programming/software engineering course, and present benefits, liabilities, and experiences with the approach comparing it to the normal, topic structured, course design....

  8. Combining engineering and data-driven approaches: Development of a generic fire risk model facilitating calibration

    DEFF Research Database (Denmark)

    De Sanctis, G.; Fischer, K.; Kohler, J.

    2014-01-01

    Fire risk models support decision making for engineering problems under the consistent consideration of the associated uncertainties. Empirical approaches can be used for cost-benefit studies when enough data about the decision problem are available. But often the empirical approaches...... are not detailed enough. Engineering risk models, on the other hand, may be detailed but typically involve assumptions that may result in a biased risk assessment and make a cost-benefit study problematic. In two related papers it is shown how engineering and data-driven modeling can be combined by developing...... a generic risk model that is calibrated to observed fire loss data. Generic risk models assess the risk of buildings based on specific risk indicators and support risk assessment at a portfolio level. After an introduction to the principles of generic risk assessment, the focus of the present paper...

  9. Nonlinear control for a diesel engine: A CLF-based approach

    Directory of Open Access Journals (Sweden)

    Kuzmych Olena

    2014-12-01

    Full Text Available In this paper, we propose a control Lyapunov function based on a nonlinear controller for a turbocharged diesel engine. A model-based approach is used which predicts the experimentally observed engine performance for a biodiesel. The basic idea is to develop an inverse optimal control and to employ a Lyapunov function in order to achieve good performances. The obtained controller gain guarantees the global convergence of the system and regulates the flows for the variable geometry turbocharger as well as exhaust gas recirculation systems in order to minimize the NOx emission and the smoke of a biodiesel engine. Simulation of the control performances based on professional software and experimental results show the effectiveness of this approach.

  10. A System-of-Systems Engineering Approach for Australian Land Force Capability Integration

    Science.gov (United States)

    2012-09-01

    Shelf NCW Network Centric Warfare NCWIIS NCW Integration and Implementation Strategy NDIA National Defense Industrial Association OCD Operational...individual rather than via the systemic approach offered by SoSE. The success of this approach is critically dependent upon the energy and presence of the...Success Factors in SoS Engineering SoSE Personnel 27. It is necessary to identify and manage critical workforce competencies. It is also essential to

  11. Teaching English for Science and Technology: An Approach for Reading with Engineering English

    Science.gov (United States)

    Porcaro, James W.

    2013-01-01

    Recognizing the relevance of English for Specific Purposes, this article outlines an approach for using authentic readings in a course in Engineering English. The article describes the importance of needs analysis, rhetorical focus, and reading for content; it suggests content for 15 lessons and provides a sample worksheet and other suggestions…

  12. Learning Probabilities in Computer Engineering by Using a Competency- and Problem-Based Approach

    Science.gov (United States)

    Khoumsi, Ahmed; Hadjou, Brahim

    2005-01-01

    Our department has redesigned its electrical and computer engineering programs by adopting a learning methodology based on competence development, problem solving, and the realization of design projects. In this article, we show how this pedagogical approach has been successfully used for learning probabilities and their application to computer…

  13. A Problem and Project-Based Learning (PBL) Approach to Motivate Group Creativity in Engineering Education

    DEFF Research Database (Denmark)

    Zhou, Chunfang; Kolmos, Anette; Nielsen, Jens Frederik Dalsgaard

    2012-01-01

    In this paper, we explore how engineering students are motivated to develop group creativity in a Problem and Project- Based Learning (PBL) environment. Theoretically, we take a social cultural approach to group creativity and emphasize the influences of a learning environment on student motivati...

  14. An industrial engineering approach to laboratory automation for high throughput screening

    Science.gov (United States)

    Menke, Karl C.

    2000-01-01

    Across the pharmaceutical industry, there are a variety of approaches to laboratory automation for high throughput screening. At Sphinx Pharmaceuticals, the principles of industrial engineering have been applied to systematically identify and develop those automated solutions that provide the greatest value to the scientists engaged in lead generation. PMID:18924701

  15. An industrial engineering approach to laboratory automation for high throughput screening

    OpenAIRE

    Menke, Karl C.

    2000-01-01

    Across the pharmaceutical industry, there are a variety of approaches to laboratory automation for high throughput screening. At Sphinx Pharmaceuticals, the principles of industrial engineering have been applied to systematically identify and develop those automated solutions that provide the greatest value to the scientists engaged in lead generation.

  16. A goal-oriented approach to identify and engineer ;and use systems.

    NARCIS (Netherlands)

    Hengsdijk, H.; Ittersum, van M.K.

    2002-01-01

    This paper describes a formalized approach to identify and engineer future-oriented land use systems. Such land use systems can be used to explore options for strategic decision making with respect to land use policy and to do ex-ante assessment of land use alternatives to be further tested or

  17. Avoid, Control, Succumb, or Balance: Engineering Students' Approaches to a Wicked Sustainability Problem

    Science.gov (United States)

    Lönngren, Johanna; Ingerman, Åke; Svanström, Magdalena

    2017-08-01

    Wicked sustainability problems (WSPs) are an important and particularly challenging type of problem. Science and engineering education can play an important role in preparing students to deal with such problems, but current educational practice may not adequately prepare students to do so. We address this gap by providing insights related to students' abilities to address WSPs. Specifically, we aim to (I) describe key constituents of engineering students' approaches to a WSP, (II) evaluate these approaches in relation to the normative context of education for sustainable development (ESD), and (III) identify relevant aspects of learning related to WSPs. Aim I is addressed through a phenomenographic study, while aims II and III are addressed by relating the results to research literature about human problem solving, sustainable development, and ESD. We describe four qualitatively different ways of approaching a specific WSP, as the outcome of the phenomenographic study: A. Simplify and avoid, B. Divide and control, C. Isolate and succumb, and D. Integrate and balance. We identify approach D as the most appropriate approach in the context of ESD, while A and C are not. On this basis, we identify three learning objectives related to students' abilities to address WSPs: learn to use a fully integrative approach, distinguish WSPs from tame and well-structured problems, and understand and consider the normative context of SD. Finally, we provide recommendations for how these learning objectives can be used to guide the design of science and engineering educational activities.

  18. Shaping the Future Landscape: Catchment Systems Engineering and the Decision Support Matrix Approach

    Science.gov (United States)

    Hewett, Caspar; Quinn, Paul; Wilkinson, Mark; Wainwright, John

    2017-04-01

    Land degradation is widely recognised as one of the great environmental challenges facing humanity today, much of which is directly associated with human activity. The negative impacts of climate change and of the way in which we have engineered the landscape through, for example, agriculture intensification and deforestation, need to be addressed. However, the answer is not a simple matter of doing the opposite of current practice. Nor is non-intervention a viable option. There is a need to bring together approaches from the natural and social sciences both to understand the issues and to act to solve real problems. We propose combining a Catchment Systems Engineering (CSE) approach that builds on existing approaches such as Natural Water Retention Measures, Green infrastructure and Nature-Based Solutions with a multi-scale framework for decision support that has been successfully applied to diffuse pollution and flood risk management. The CSE philosophy follows that of Earth Systems Engineering and Management, which aims to engineer and manage complex coupled human-natural systems in a highly integrated, rational manner. CSE is multi-disciplinary, and necessarily involves a wide range of subject areas including anthropology, engineering, environmental science, ethics and philosophy. It offers a rational approach which accepts the fact that we need to engineer and act to improve the functioning of the existing catchment entity on which we rely. The decision support framework proposed draws on physical and mathematical modelling; Participatory Action Research; and demonstration sites at which practical interventions are implemented. It is predicated on the need to work with stakeholders to co-produce knowledge that leads to proactive interventions to reverse the land degradation we observe today while sustaining the agriculture humanity needs. The philosophy behind CSE and examples of where it has been applied successfully are presented. The Decision Support Matrix

  19. Integrating Communication into Engineering Curricula: An Interdisciplinary Approach to Facilitating Transfer at New Mexico Institute of Mining and Technology

    Science.gov (United States)

    Ford, Julie Dyke

    2012-01-01

    This program profile describes a new approach towards integrating communication within Mechanical Engineering curricula. The author, who holds a joint appointment between Technical Communication and Mechanical Engineering at New Mexico Institute of Mining and Technology, has been collaborating with Mechanical Engineering colleagues to establish a…

  20. Metabolic engineering and synthetic biology approaches driving isoprenoid production in Escherichia coli.

    Science.gov (United States)

    Wang, Chonglong; Zada, Bakht; Wei, Gongyuan; Kim, Seon-Won

    2017-10-01

    Isoprenoids comprise the largest family of natural organic compounds with many useful applications in the pharmaceutical, nutraceutical, and industrial fields. Rapid developments in metabolic engineering and synthetic biology have facilitated the engineering of isoprenoid biosynthetic pathways in Escherichia coli to induce high levels of production of many different isoprenoids. In this review, the stem pathways for synthesizing isoprene units as well as the branch pathways deriving diverse isoprenoids from the isoprene units have been summarized. The review also highlights the metabolic engineering efforts made for the biosynthesis of hemiterpenoids, monoterpenoids, sesquiterpenoids, diterpenoids, carotenoids, retinoids, and coenzyme Q 10 in E. coli. Perspectives and future directions for the synthesis of novel isoprenoids, decoration of isoprenoids using cytochrome P450 enzymes, and secretion or storage of isoprenoids in E. coli have also been included. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Safety, reliability, risk management and human factors: an integrated engineering approach applied to nuclear facilities

    International Nuclear Information System (INIS)

    Vasconcelos, Vanderley de; Silva, Eliane Magalhaes Pereira da; Costa, Antonio Carlos Lopes da; Reis, Sergio Carneiro dos

    2009-01-01

    Nuclear energy has an important engineering legacy to share with the conventional industry. Much of the development of the tools related to safety, reliability, risk management, and human factors are associated with nuclear plant processes, mainly because the public concern about nuclear power generation. Despite the close association between these subjects, there are some important different approaches. The reliability engineering approach uses several techniques to minimize the component failures that cause the failure of the complex systems. These techniques include, for instance, redundancy, diversity, standby sparing, safety factors, and reliability centered maintenance. On the other hand system safety is primarily concerned with hazard management, that is, the identification, evaluation and control of hazards. Rather than just look at failure rates or engineering strengths, system safety would examine the interactions among system components. The events that cause accidents may be complex combinations of component failures, faulty maintenance, design errors, human actions, or actuation of instrumentation and control. Then, system safety deals with a broader spectrum of risk management, including: ergonomics, legal requirements, quality control, public acceptance, political considerations, and many other non-technical influences. Taking care of these subjects individually can compromise the completeness of the analysis and the measures associated with both risk reduction, and safety and reliability increasing. Analyzing together the engineering systems and controls of a nuclear facility, their management systems and operational procedures, and the human factors engineering, many benefits can be realized. This paper proposes an integration of these issues based on the application of systems theory. (author)

  2. A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches.

    Science.gov (United States)

    Cantone, Irene; Marucci, Lucia; Iorio, Francesco; Ricci, Maria Aurelia; Belcastro, Vincenzo; Bansal, Mukesh; Santini, Stefania; di Bernardo, Mario; di Bernardo, Diego; Cosma, Maria Pia

    2009-04-03

    Systems biology approaches are extensively used to model and reverse engineer gene regulatory networks from experimental data. Conversely, synthetic biology allows "de novo" construction of a regulatory network to seed new functions in the cell. At present, the usefulness and predictive ability of modeling and reverse engineering cannot be assessed and compared rigorously. We built in the yeast Saccharomyces cerevisiae a synthetic network, IRMA, for in vivo "benchmarking" of reverse-engineering and modeling approaches. The network is composed of five genes regulating each other through a variety of regulatory interactions; it is negligibly affected by endogenous genes, and it is responsive to small molecules. We measured time series and steady-state expression data after multiple perturbations. These data were used to assess state-of-the-art modeling and reverse-engineering techniques. A semiquantitative model was able to capture and predict the behavior of the network. Reverse engineering based on differential equations and Bayesian networks correctly inferred regulatory interactions from the experimental data.

  3. Regenerative endodontics as a tissue engineering approach: past, current and future.

    Science.gov (United States)

    Malhotra, Neeraj; Mala, Kundabala

    2012-12-01

    With the reported startling statistics of high incidence of tooth decay and tooth loss, the current interest is focused on the development of alternate dental tissue replacement therapies. This has led to the application of dental tissue engineering as a clinically relevant method for the regeneration of dental tissues and generation of bioengineered whole tooth. Although, tissue engineering approach requires the three main key elements of stem cells, scaffold and morphogens, a conductive environment (fourth element) is equally important for successful engineering of any tissue and/or organ. The applications of this science has evolved continuously in dentistry, beginning from the application of Ca(OH)(2) in vital pulp therapy to the development of a fully functional bioengineered tooth (mice). Thus, with advances in basic research, recent reports and studies have shown successful application of tissue engineering in the field of dentistry. However, certain practical obstacles are yet to be overcome before dental tissue regeneration can be applied as evidence-based approach in clinics. The article highlights on the past achievements, current developments and future prospects of tissue engineering and regenerative therapy in the field of endodontics and bioengineered teeth (bioteeth). © 2012 The Authors. Australian Endodontic Journal © 2012 Australian Society of Endodontology.

  4. Safety, reliability, risk management and human factors: an integrated engineering approach applied to nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    Vasconcelos, Vanderley de; Silva, Eliane Magalhaes Pereira da; Costa, Antonio Carlos Lopes da; Reis, Sergio Carneiro dos [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)], e-mail: vasconv@cdtn.br, e-mail: silvaem@cdtn.br, e-mail: aclc@cdtn.br, e-mail: reissc@cdtn.br

    2009-07-01

    Nuclear energy has an important engineering legacy to share with the conventional industry. Much of the development of the tools related to safety, reliability, risk management, and human factors are associated with nuclear plant processes, mainly because the public concern about nuclear power generation. Despite the close association between these subjects, there are some important different approaches. The reliability engineering approach uses several techniques to minimize the component failures that cause the failure of the complex systems. These techniques include, for instance, redundancy, diversity, standby sparing, safety factors, and reliability centered maintenance. On the other hand system safety is primarily concerned with hazard management, that is, the identification, evaluation and control of hazards. Rather than just look at failure rates or engineering strengths, system safety would examine the interactions among system components. The events that cause accidents may be complex combinations of component failures, faulty maintenance, design errors, human actions, or actuation of instrumentation and control. Then, system safety deals with a broader spectrum of risk management, including: ergonomics, legal requirements, quality control, public acceptance, political considerations, and many other non-technical influences. Taking care of these subjects individually can compromise the completeness of the analysis and the measures associated with both risk reduction, and safety and reliability increasing. Analyzing together the engineering systems and controls of a nuclear facility, their management systems and operational procedures, and the human factors engineering, many benefits can be realized. This paper proposes an integration of these issues based on the application of systems theory. (author)

  5. Effects of the Interest Rate and Reserve Requirement Ratio on Bank Risk in China: A Panel Smooth Transition Regression Approach

    Directory of Open Access Journals (Sweden)

    Zhongyuan Geng

    2015-01-01

    Full Text Available This paper applies the Panel Smooth Transition Regression (PSTR model to simulate the effects of the interest rate and reserve requirement ratio on bank risk in China. The results reveal the nonlinearity embedded in the interest rate, reserve requirement ratio, and bank risk nexus. Both the interest rate and reserve requirement ratio exert a positive impact on bank risk for the low regime and a negative impact for the high regime. The interest rate performs a significant effect while the reserve requirement ratio shows an insignificant effect on bank risk on a statistical basis for both the high and low regimes.

  6. Recent Progress on Systems and Synthetic Biology Approaches to Engineer Fungi As Microbial Cell Factories.

    Science.gov (United States)

    Amores, Gerardo Ruiz; Guazzaroni, María-Eugenia; Arruda, Letícia Magalhães; Silva-Rocha, Rafael

    2016-04-01

    Filamentous fungi are remarkable organisms naturally specialized in deconstructing plant biomass and this feature has a tremendous potential for biofuel production from renewable sources. The past decades have been marked by a remarkable progress in the genetic engineering of fungi to generate industry-compatible strains needed for some biotech applications. In this sense, progress in this field has been marked by the utilization of high-throughput techniques to gain deep understanding of the molecular machinery controlling the physiology of these organisms, starting thus the Systems Biology era of fungi. Additionally, genetic engineering has been extensively applied to modify wellcharacterized promoters in order to construct new expression systems with enhanced performance under the conditions of interest. In this review, we discuss some aspects related to significant progress in the understating and engineering of fungi for biotechnological applications, with special focus on the construction of synthetic promoters and circuits in organisms relevant for industry. Different engineering approaches are shown, and their potential and limitations for the construction of complex synthetic circuits in these organisms are examined. Finally, we discuss the impact of engineered promoter architecture in the single-cell behavior of the system, an often-neglected relationship with a tremendous impact in the final performance of the process of interest. We expect to provide here some new directions to drive future research directed to the construction of high-performance, engineered fungal strains working as microbial cell factories.

  7. Engineering approach to relative quantitative assessment of safety culture and related social issues in NPP operation

    International Nuclear Information System (INIS)

    Sivokon, V.; Gladyshev, M.; Malkin, S.

    2005-01-01

    The report is devoted to presentation of engineering approach and software tool developed for Safety Culture (SC) assessment as well as to the results of their implementation at Smolensk NPP. The engineering approach is logic evolution of the IAEA ASSET method broadly used at European NPPs in 90-s. It was implemented at Russian and other plants including Olkiluoto NPP in Finland. The approach allows relative quantitative assessing and trending the aspects of SC by the analysis of evens features and causes, calculation and trending corresponding indicators. At the same time plant's operational performances and related social issues, including efficiency of plant operation and personnel reliability, can be monitored. With the help of developed tool the joint team combined from personnel of Smolensk NPP and RRC 'Kurchatov Institute' ('KI') issued the SC self-assessment report, which identifies: families of recurrent events, main safety and operational problems ; their trends and importance to SC and plant efficiency; recommendations to enhance SC and operational performance

  8. An approach for reduction of false predictions in reverse engineering of gene regulatory networks.

    Science.gov (United States)

    Khan, Abhinandan; Saha, Goutam; Pal, Rajat Kumar

    2018-05-14

    A gene regulatory network discloses the regulatory interactions amongst genes, at a particular condition of the human body. The accurate reconstruction of such networks from time-series genetic expression data using computational tools offers a stiff challenge for contemporary computer scientists. This is crucial to facilitate the understanding of the proper functioning of a living organism. Unfortunately, the computational methods produce many false predictions along with the correct predictions, which is unwanted. Investigations in the domain focus on the identification of as many correct regulations as possible in the reverse engineering of gene regulatory networks to make it more reliable and biologically relevant. One way to achieve this is to reduce the number of incorrect predictions in the reconstructed networks. In the present investigation, we have proposed a novel scheme to decrease the number of false predictions by suitably combining several metaheuristic techniques. We have implemented the same using a dataset ensemble approach (i.e. combining multiple datasets) also. We have employed the proposed methodology on real-world experimental datasets of the SOS DNA Repair network of Escherichia coli and the IMRA network of Saccharomyces cerevisiae. Subsequently, we have experimented upon somewhat larger, in silico networks, namely, DREAM3 and DREAM4 Challenge networks, and 15-gene and 20-gene networks extracted from the GeneNetWeaver database. To study the effect of multiple datasets on the quality of the inferred networks, we have used four datasets in each experiment. The obtained results are encouraging enough as the proposed methodology can reduce the number of false predictions significantly, without using any supplementary prior biological information for larger gene regulatory networks. It is also observed that if a small amount of prior biological information is incorporated here, the results improve further w.r.t. the prediction of true positives

  9. Human Factors and Systems Engineering Approach to Patient Safety for Radiotherapy

    International Nuclear Information System (INIS)

    Rivera, A. Joy; Karsh, Ben-Tzion

    2008-01-01

    The traditional approach to solving patient safety problems in healthcare is to blame the last person to touch the patient. But since the publication of To Err is Human, the call has been instead to use human factors and systems engineering methods and principles to solve patient safety problems. However, an understanding of the human factors and systems engineering is lacking, and confusion remains about what it means to apply their principles. This paper provides a primer on them and their applications to patient safety

  10. Review of the Space Mapping Approach to Engineering Optimization and Modeling

    DEFF Research Database (Denmark)

    Bakr, M. H.; Bandler, J. W.; Madsen, Kaj

    2000-01-01

    We review the Space Mapping (SM) concept and its applications in engineering optimization and modeling. The aim of SM is to avoid computationally expensive calculations encountered in simulating an engineering system. The existence of less accurate but fast physically-based models is exploited. SM......). An essential subproblem of any SM based optimization algorithm is parameter extraction. The uniqueness of this optimization subproblem has been crucial to the success of SM optimization. Different approaches to enhance the uniqueness are reviewed. We also discuss new developments in Space Mapping...

  11. Durable ideas in software engineering concepts, methods and approaches from my virtual toolbox

    CERN Document Server

    J Cusick, James

    2013-01-01

    ""Software Engineering now occupies a central place in the development of technology and in the advancement of the economy. From telecommunications to aerospace and from cash registers to medical imaging, software plays a vital and often decisive role in the successful accomplishment of a variety of projects. The creation of software requires a variety of techniques, tools, and especially, properly skilled engineers. This e-book focuses on core concepts and approaches that have proven useful to the author time and time again on many industry projects over a quarter century of research, develo

  12. Numerical Prediction of CCV in a PFI Engine using a Parallel LES Approach

    Energy Technology Data Exchange (ETDEWEB)

    Ameen, Muhsin M; Mirzaeian, Mohsen; Millo, Federico; Som, Sibendu

    2017-10-15

    Cycle-to-cycle variability (CCV) is detrimental to IC engine operation and can lead to partial burn, misfire, and knock. Predicting CCV numerically is extremely challenging due to two key reasons. Firstly, high-fidelity methods such as large eddy simulation (LES) are required to accurately resolve the incylinder turbulent flowfield both spatially and temporally. Secondly, CCV is experienced over long timescales and hence the simulations need to be performed for hundreds of consecutive cycles. Ameen et al. (Int. J. Eng. Res., 2017) developed a parallel perturbation model (PPM) approach to dissociate this long time-scale problem into several shorter timescale problems. The strategy is to perform multiple single-cycle simulations in parallel by effectively perturbing the initial velocity field based on the intensity of the in-cylinder turbulence. This strategy was demonstrated for motored engine and it was shown that the mean and variance of the in-cylinder flowfield was captured reasonably well by this approach. In the present study, this PPM approach is extended to simulate the CCV in a fired port-fuel injected (PFI) SI engine. Two operating conditions are considered – a medium CCV operating case corresponding to 2500 rpm and 16 bar BMEP and a low CCV case corresponding to 4000 rpm and 12 bar BMEP. The predictions from this approach are also shown to be similar to the consecutive LES cycles. Both the consecutive and PPM LES cycles are observed to under-predict the variability in the early stage of combustion. The parallel approach slightly underpredicts the cyclic variability at all stages of combustion as compared to the consecutive LES cycles. However, it is shown that the parallel approach is able to predict the coefficient of variation (COV) of the in-cylinder pressure and burn rate related parameters with sufficient accuracy, and is also able to predict the qualitative trends in CCV with changing operating conditions. The convergence of the statistics

  13. A Novel Outreach to High School Students by Teaching Them the Engineering Skills in a Project-Based Approach

    Science.gov (United States)

    Asiabanpour, Bahram

    2010-01-01

    In this paper a novel outreach approach to high school students to familiarize them with engineering functions and methods is explained. In this approach students participated in a seven days research camp and learned many engineering skills and tools such as CAD solid modeling, finite element analysis, rapid prototyping, mechanical tests, team…

  14. A Value-Based Business Approach to Product Line Software Engineering

    Directory of Open Access Journals (Sweden)

    Raman K. Agrawalla

    2009-08-01

    Full Text Available The present conceptual paper is an attempt to provide a Value-Based Business Approach (VBBA to product line software engineering. It argues that Product line software engineering should be seen as a system and considered as a means towards the end of appropriating more and more value for the business firm; contingent upon the fact that it provides value to customer and customer's customers operating its value creating system with agility, speed, economy and innovation; getting governed by the positive sum value creation outlook and guided by value- based management. With our value-based business triad, the product line engineering process can hope to achieve simultaneously value, variety and volume, product differentiation and cost leadership enabling the business firm to land on the virtuous value spiral.

  15. On the Brink of Shifting Paradigms, Molecular Systems Engineering Ethics Needs to Take a Proactive Approach.

    Science.gov (United States)

    Heidari, Raheleh; Elger, Bernice S; Stutzki, Ralf

    2016-01-01

    Molecular Systems Engineering (MSE) is a paradigm shift in both engineering and life sciences. While the field is still in its infancy the perspectives of MSE in revolutionising technology is promising. MSE will offer a wide range of applications in clinical, biotechnological and engineering fields while simultaneously posing serious questions on the ethical and societal aspects of such technology. The moral and societal aspects of MSE need systematic investigation from scientific and social perspectives. In a democratic setting, the societal outcomes of MSE's cutting-edge technology need to be consulted and influenced by society itself. For this purpose MSE needs inclusive public engagement strategies that bring together the public, ethicists, scientists and policy makers for optimum flow of information that maximizes the impact of public engagement. In this report we present an MSE consortium and its ethics framework for establishing a proactive approach in the study of the ethics of MSE technology.

  16. An engineering approach to modelling, decision support and control for sustainable systems.

    Science.gov (United States)

    Day, W; Audsley, E; Frost, A R

    2008-02-12

    Engineering research and development contributes to the advance of sustainable agriculture both through innovative methods to manage and control processes, and through quantitative understanding of the operation of practical agricultural systems using decision models. This paper describes how an engineering approach, drawing on mathematical models of systems and processes, contributes new methods that support decision making at all levels from strategy and planning to tactics and real-time control. The ability to describe the system or process by a simple and robust mathematical model is critical, and the outputs range from guidance to policy makers on strategic decisions relating to land use, through intelligent decision support to farmers and on to real-time engineering control of specific processes. Precision in decision making leads to decreased use of inputs, less environmental emissions and enhanced profitability-all essential to sustainable systems.

  17. Concurrent Engineering Approaches for Sustainable Product Development in a Multi-Disciplinary Environment : Proceedings of the 19th ISPE International Conference on Concurrent Engineering

    CERN Document Server

    Rock, Georg; Bil, Cees

    2013-01-01

    The CE Conference series is organized annually by the International Society for Productivity Enhancement (ISPE) and constitutes an important forum for international scientific exchange on concurrent and collaborative enterprise engineering. These international conferences attract a significant number of researchers, industrialists and students, as well as government representatives, who are interested in the recent advances in concurrent engineering research and applications. Concurrent Engineering Approaches for Sustainable Product Development in a Multi-Disciplinary Environment: Proceedings of the 19th ISPE International Conference on Concurrent Engineering contains papers accepted, peer reviewed and presented at the annual conference held  at the University of Applied Sciences in Trier, Germany, from 3rd-7th of September 2012. This covers a wide range of cutting-edge topics including: •Systems Engineering and Innovation •Design for Sustainability •Knowledge Engineering and Management •Managing pro...

  18. Development of field programmable gate array-based reactor trip functions using systems engineering approach

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jae Cheon; Ahmed, Ibrahim [Nuclear Power Plant Engineering, KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2016-08-15

    Design engineering process for field programmable gate array (FPGA)-based reactor trip functions are developed in this work. The process discussed in this work is based on the systems engineering approach. The overall design process is effectively implemented by combining with design and implementation processes. It transforms its overall development process from traditional V-model to Y-model. This approach gives the benefit of concurrent engineering of design work with software implementation. As a result, it reduces development time and effort. The design engineering process consisted of five activities, which are performed and discussed: needs/systems analysis; requirement analysis; functional analysis; design synthesis; and design verification and validation. Those activities are used to develop FPGA-based reactor bistable trip functions that trigger reactor trip when the process input value exceeds the setpoint. To implement design synthesis effectively, a model-based design technique is implied. The finite-state machine with data path structural modeling technique together with very high speed integrated circuit hardware description language and the Aldec Active-HDL tool are used to design, model, and verify the reactor bistable trip functions for nuclear power plants.

  19. A survey of the practices of the approaches taught in an industrial engineering undergraduate program

    Directory of Open Access Journals (Sweden)

    Al-Ghamdi, Khalid A.

    2014-08-01

    Full Text Available The Saudi labour market has recently witnessed intense competition between locally- graduated Industrial Engineers and those graduating from international universities. This has compelled local IE departments to find ways to improve the quality of their educational programmes and to ensure their alignment with the labour market’s needs. To this end, insightful information can be obtained by contacting alumni and soliciting their perceptions of their education. However, empirical investigations based on this approach are rarely reported in the literature. To fill this gap, this study reports the results of a survey that was conducted to examine the gap between what is practised and what is taught in the Industrial Engineering (IE programme at King Abdulaziz University (KAU. Apart from discussing the main characteristics of the alumni’s employers, the study revealed that ‘Engineering Economy’ involves the most applied techniques in practice, whereas ‘Engineering Management’ incorporates the most applicable approaches. The limited use of IE techniques was mainly attributed to poor cooperation between practitioners and academics, and the simplistic nature of the problems addressed in the university curriculum compared with complex real-life ones. To deal with some of the identified problems, this paper argues for advisory board members to engage with industry when designing the curriculum, and for the adoption of problem-based learning.

  20. Systematic Approach to Training for System Engineers in Nuclear Power Plants

    International Nuclear Information System (INIS)

    Kwak, Jeong-keun

    2015-01-01

    In my paper, comprehensive preparations, tangible applications, and final establishments of training for system engineers are described using practical materials in KHNP. The purpose of this paper is to formulate SAT based training in KHNP, especially for system engineers. Hence, to achieve this goal, over one year study was performed considering voluminous materials and working experiences. Through the process, SAT based training package for system engineers was finished, in the end. In terms of training in NPPs, SAT methodology is the unwavering trend in South Korea since NPPs export to UAE. Therefore, materialization of SAT based training for system engineers from the origin of SAT to the finalization of SAT should not be overlooked. A variety of accident preventive approaches have been adopted since the first commercial NPP operation in Calder Hall, United Kingdom. Among diverse event preventive ways, training has played an important role for the improvement of NPPs reliability and safety. This is reason why nuclear industry in every country has established and maintained own training institutes and methods. Since the Three Mile Island (TMI) accident, United States Nuclear Regulatory Commission (USNRC) recommended many betterment plans to US nuclear industry for the elevation of NPPs safety. In the suggested considerations, systematic approach to training, so called SAT appeared in the world. Basically, SAT is composed of five stages, what is called ADDIE. Hence, through ADDIE process, holistic and trustworthy training could be realized in the actual NPPs operation and maintenance. For this reason, SAT is the representative training methodology in the US nuclear business

  1. Systematic Approach to Training for System Engineers in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, Jeong-keun [Korea Hydro and Nuclear Power Co., Ulsan (Korea, Republic of)

    2015-10-15

    In my paper, comprehensive preparations, tangible applications, and final establishments of training for system engineers are described using practical materials in KHNP. The purpose of this paper is to formulate SAT based training in KHNP, especially for system engineers. Hence, to achieve this goal, over one year study was performed considering voluminous materials and working experiences. Through the process, SAT based training package for system engineers was finished, in the end. In terms of training in NPPs, SAT methodology is the unwavering trend in South Korea since NPPs export to UAE. Therefore, materialization of SAT based training for system engineers from the origin of SAT to the finalization of SAT should not be overlooked. A variety of accident preventive approaches have been adopted since the first commercial NPP operation in Calder Hall, United Kingdom. Among diverse event preventive ways, training has played an important role for the improvement of NPPs reliability and safety. This is reason why nuclear industry in every country has established and maintained own training institutes and methods. Since the Three Mile Island (TMI) accident, United States Nuclear Regulatory Commission (USNRC) recommended many betterment plans to US nuclear industry for the elevation of NPPs safety. In the suggested considerations, systematic approach to training, so called SAT appeared in the world. Basically, SAT is composed of five stages, what is called ADDIE. Hence, through ADDIE process, holistic and trustworthy training could be realized in the actual NPPs operation and maintenance. For this reason, SAT is the representative training methodology in the US nuclear business.

  2. A Model-Based Anomaly Detection Approach for Analyzing Streaming Aircraft Engine Measurement Data

    Science.gov (United States)

    Simon, Donald L.; Rinehart, Aidan Walker

    2015-01-01

    This paper presents a model-based anomaly detection architecture designed for analyzing streaming transient aircraft engine measurement data. The technique calculates and monitors residuals between sensed engine outputs and model predicted outputs for anomaly detection purposes. Pivotal to the performance of this technique is the ability to construct a model that accurately reflects the nominal operating performance of the engine. The dynamic model applied in the architecture is a piecewise linear design comprising steady-state trim points and dynamic state space matrices. A simple curve-fitting technique for updating the model trim point information based on steadystate information extracted from available nominal engine measurement data is presented. Results from the application of the model-based approach for processing actual engine test data are shown. These include both nominal fault-free test case data and seeded fault test case data. The results indicate that the updates applied to improve the model trim point information also improve anomaly detection performance. Recommendations for follow-on enhancements to the technique are also presented and discussed.

  3. Science, technology, engineering, mathematics (STEM) as mathematics learning approach in 21st century

    Science.gov (United States)

    Milaturrahmah, Naila; Mardiyana, Pramudya, Ikrar

    2017-08-01

    This 21st century demands competent human resources in science, technology, engineering design and mathematics so that education is expected to integrate the four disciplines. This paper aims to describe the importance of STEM as mathematics learning approach in Indonesia in the 21st century. This paper uses a descriptive analysis research method, and the method reveals that STEM education growing in developed countries today can be a framework for innovation mathematics in Indonesia in the 21st century. STEM education integrate understanding of science, math skills, and the available technology with the ability to perform engineering design process. Implementation of mathematics learning with STEM approach makes graduates trained in using of mathematics knowledge that they have to create innovative products that are able to solve the problems that exist in society.

  4. Systems engineering approach to U.S. Department of Energy's commercial nuclear waste transportation program

    International Nuclear Information System (INIS)

    Pardue, W.M.

    1987-01-01

    The U.S Department of Energy (DOE) has been given the responsibility of developing a program to transport commercially produced spent nuclear fuel and high-level radioactive wastes to disposal sites or storage facilities safely and cost-effectively. To accomplish this task it is desirable to plan, perform, and document all technical activities based on systems engineering principles. This paper presents an overview of the systems engineering approach being developed by Battelle for consideration by DOE, specifically the early identification of the required technical activities and approaches to technical management and decision making. The program should support the development of an integrated, well-documented transportation system acceptable to regulatory agencies and the public

  5. Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus.

    Science.gov (United States)

    Cucchiarini, M; McNulty, A L; Mauck, R L; Setton, L A; Guilak, F; Madry, H

    2016-08-01

    Meniscal lesions are common problems in orthopaedic surgery and sports medicine, and injury or loss of the meniscus accelerates the onset of knee osteoarthritis (OA). Despite a variety of therapeutic options in the clinics, there is a critical need for improved treatments to enhance meniscal repair. In this regard, combining gene-, cell-, and tissue engineering-based approaches is an attractive strategy to generate novel, effective therapies to treat meniscal lesions. In the present work, we provide an overview of the tools currently available to improve meniscal repair and discuss the progress and remaining challenges for potential future translation in patients. Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  6. Using A Model-Based Systems Engineering Approach For Exploration Medical System Development

    Science.gov (United States)

    Hanson, A.; Mindock, J.; McGuire, K.; Reilly, J.; Cerro, J.; Othon, W.; Rubin, D.; Urbina, M.; Canga, M.

    2017-01-01

    NASA's Human Research Program's Exploration Medical Capabilities (ExMC) element is defining the medical system needs for exploration class missions. ExMC's Systems Engineering (SE) team will play a critical role in successful design and implementation of the medical system into exploration vehicles. The team's mission is to "Define, develop, validate, and manage the technical system design needed to implement exploration medical capabilities for Mars and test the design in a progression of proving grounds." Development of the medical system is being conducted in parallel with exploration mission architecture and vehicle design development. Successful implementation of the medical system in this environment will require a robust systems engineering approach to enable technical communication across communities to create a common mental model of the emergent engineering and medical systems. Model-Based Systems Engineering (MBSE) improves shared understanding of system needs and constraints between stakeholders and offers a common language for analysis. The ExMC SE team is using MBSE techniques to define operational needs, decompose requirements and architecture, and identify medical capabilities needed to support human exploration. Systems Modeling Language (SysML) is the specific language the SE team is utilizing, within an MBSE approach, to model the medical system functional needs, requirements, and architecture. Modeling methods are being developed through the practice of MBSE within the team, and tools are being selected to support meta-data exchange as integration points to other system models are identified. Use of MBSE is supporting the development of relationships across disciplines and NASA Centers to build trust and enable teamwork, enhance visibility of team goals, foster a culture of unbiased learning and serving, and be responsive to customer needs. The MBSE approach to medical system design offers a paradigm shift toward greater integration between

  7. Integrated approaches for implementing building information modelling (BIM) in engineering education

    OpenAIRE

    Hjelseth, Eilif

    2015-01-01

    The construction industry faces high demand for candidates with relevant Building Information Modelling (BIM) competency, yet higher education continues to struggle in providing such competencies. This conceptual paper explores the use of an integrated approach to implement BIM into the curriculum for undergraduates and graduates in engineering. The curriculum under study employed the Technological Pedagogical Content Knowledge (TPACK) pedagogical framework for integrating three BIM related s...

  8. A multi-criteria optimization and decision-making approach for improvement of food engineering processes

    Directory of Open Access Journals (Sweden)

    Alik Abakarov

    2013-04-01

    Full Text Available The objective of this study was to propose a multi-criteria optimization and decision-making technique to solve food engineering problems. This technique was demonstrated using experimental data obtained on osmotic dehydration of carrot cubes in a sodium chloride solution. The Aggregating Functions Approach, the Adaptive Random Search Algorithm, and the Penalty Functions Approach were used in this study to compute the initial set of non-dominated or Pareto-optimal solutions. Multiple non-linear regression analysis was performed on a set of experimental data in order to obtain particular multi-objective functions (responses, namely water loss, solute gain, rehydration ratio, three different colour criteria of rehydrated product, and sensory evaluation (organoleptic quality. Two multi-criteria decision-making approaches, the Analytic Hierarchy Process (AHP and the Tabular Method (TM, were used simultaneously to choose the best alternative among the set of non-dominated solutions. The multi-criteria optimization and decision-making technique proposed in this study can facilitate the assessment of criteria weights, giving rise to a fairer, more consistent, and adequate final compromised solution or food process. This technique can be useful to food scientists in research and education, as well as to engineers involved in the improvement of a variety of food engineering processes.

  9. NASA's Space Launch System: Systems Engineering Approach for Affordability and Mission Success

    Science.gov (United States)

    Hutt, John J.; Whitehead, Josh; Hanson, John

    2017-01-01

    NASA is working toward the first launch of the Space Launch System, a new, unmatched capability for deep space exploration with launch readiness planned for 2019. Since program start in 2011, SLS has passed several major formal design milestones, and every major element of the vehicle has produced test and flight hardware. The SLS approach to systems engineering has been key to the program's success. Key aspects of the SLS SE&I approach include: 1) minimizing the number of requirements, 2) elimination of explicit verification requirements, 3) use of certified models of subsystem capability in lieu of requirements when appropriate and 4) certification of capability beyond minimum required capability.

  10. A Systematic Approach for Model-Based Aircraft Engine Performance Estimation

    Science.gov (United States)

    Simon, Donald L.; Garg, Sanjay

    2010-01-01

    A requirement for effective aircraft engine performance estimation is the ability to account for engine degradation, generally described in terms of unmeasurable health parameters such as efficiencies and flow capacities related to each major engine module. This paper presents a linear point design methodology for minimizing the degradation-induced error in model-based aircraft engine performance estimation applications. The technique specifically focuses on the underdetermined estimation problem, where there are more unknown health parameters than available sensor measurements. A condition for Kalman filter-based estimation is that the number of health parameters estimated cannot exceed the number of sensed measurements. In this paper, the estimated health parameter vector will be replaced by a reduced order tuner vector whose dimension is equivalent to the sensed measurement vector. The reduced order tuner vector is systematically selected to minimize the theoretical mean squared estimation error of a maximum a posteriori estimator formulation. This paper derives theoretical estimation errors at steady-state operating conditions, and presents the tuner selection routine applied to minimize these values. Results from the application of the technique to an aircraft engine simulation are presented and compared to the estimation accuracy achieved through conventional maximum a posteriori and Kalman filter estimation approaches. Maximum a posteriori estimation results demonstrate that reduced order tuning parameter vectors can be found that approximate the accuracy of estimating all health parameters directly. Kalman filter estimation results based on the same reduced order tuning parameter vectors demonstrate that significantly improved estimation accuracy can be achieved over the conventional approach of selecting a subset of health parameters to serve as the tuner vector. However, additional development is necessary to fully extend the methodology to Kalman filter

  11. Theoretical Acoustic Absorber Design Approach for LOX/LCH4 Pintle Injector Rocket Engines

    Science.gov (United States)

    Candelaria, Jonathan

    Liquid rocket engines, or LREs, have served a key role in space exploration efforts. One current effort involves the utilization of liquid oxygen (LOX) and liquid methane (LCH4) LREs to explore Mars with in-situ resource utilization for propellant production. This on-site production of propellant will allow for greater payload allocation instead of fuel to travel to the Mars surface, and refueling of propellants to travel back to Earth. More useable mass yields a greater benefit to cost ratio. The University of Texas at El Paso's (UTEP) Center for Space Exploration and Technology Research Center (cSETR) aims to further advance these methane propulsion systems with the development of two liquid methane - liquid oxygen propellant combination rocket engines. The design of rocket engines, specifically liquid rocket engines, is complex in that many variables are present that must be taken into consideration in the design. A problem that occurs in almost every rocket engine development program is combustion instability, or oscillatory combustion. It can result in the destruction of the rocket, subsequent destruction of the vehicle and compromise the mission. These combustion oscillations can vary in frequency from 100 to 20,000 Hz or more, with varying effects, and occur from different coupling phenomena. It is important to understand the effects of combustion instability, its physical manifestations, how to identify the instabilities, and how to mitigate or dampen them. Linear theory methods have been developed to provide a mathematical understanding of the low- to mid-range instabilities. Nonlinear theory is more complex and difficult to analyze mathematically, therefore no general analytical method that yields a solution exists. With limited resources, time, and the advice of our NASA mentors, a data driven experimental approach utilizing quarter wave acoustic dampener cavities was designed. This thesis outlines the methodology behind the design of an acoustic

  12. Impact of typhoon disturbance on the diversity of key ecosystem engineers in a monoculture mangrove forest plantation, Can Gio Biosphere Reserve, Vietnam

    Science.gov (United States)

    Diele, K.; Tran Ngoc, D. M.; Geist, S. J.; Meyer, F. W.; Pham, Q. H.; Saint-Paul, U.; Tran, T.; Berger, U.

    2013-11-01

    Mangrove crabs as key ecosystem engineers may play an important role in the recovery process of storm-damaged forests. Yet, their response to storm disturbance is largely unknown. Here we compare the ground-dwelling brachyuran crab community of intact mangrove stands with that of typhoon gaps having experienced 100% tree mortality. Field work was conducted in two adjacent areas in Can Gio Biosphere Reserve, southern Vietnam. In each area, an 18-20 yr old monoculture Rhizophora apiculata stand served as control and was compared with typhoon gaps where downed stems had been removed or left on-site. The gaps were 14 and 20 months old when studied in the dry and rainy season 2008, respectively. Time-based sampling of ground-dwelling crabs with hand or shovel was conducted by 4 persons inside 100 m2 plots for 30 min (7 replicate plots per area, treatment and month). Abiotic (sediment pH, salinity, temperature, grain size, water content, carbon and nitrogen content), and biotic measures (e.g. canopy coverage, woody debris, number of trees, leaf litter) were also taken. Despite complete canopy loss, total crab abundance has not changed significantly (in contrast to biomass) and all 12 species found in the forest were also found in the gaps, demonstrating their robustness. Another 9 gap-exclusive species were recorded and average species number and Shannon diversity were thus higher in the gaps. Perisesarma eumolpe was the most abundant species, both in the forest and in the gaps, and a shift from sesarmids (typical forest species) to ocypodids (generally more prominent in open areas) has not occurred. The persistence of litter-feeding sesarmid crabs prior to the re-establishment of a mangrove canopy is likely to depend on the availability of woody debris on the ground of the gaps, fuelling a mangrove detritus based food web, rather than one based on microphytobenthos and deposit-feeding ocypodids. The presence of burrowing crabs in the gaps suggests that important

  13. Rational, combinatorial, and genomic approaches for engineering L-tyrosine production in Escherichia coli.

    Science.gov (United States)

    Santos, Christine Nicole S; Xiao, Wenhai; Stephanopoulos, Gregory

    2012-08-21

    Although microbial metabolic engineering has traditionally relied on rational and knowledge-driven techniques, significant improvements in strain performance can be further obtained through the use of combinatorial approaches exploiting phenotypic diversification and screening. Here, we demonstrate the combined use of global transcriptional machinery engineering and a high-throughput L-tyrosine screen towards improving L-tyrosine production in Escherichia coli. This methodology succeeded in generating three strains from two separate mutagenesis libraries (rpoA and rpoD) exhibiting up to a 114% increase in L-tyrosine titer over a rationally engineered parental strain with an already high capacity for production. Subsequent strain characterization through transcriptional analysis and whole genome sequencing allowed complete phenotype reconstruction from well-defined mutations and point to important roles for both the acid stress resistance pathway and the stringent response of E. coli in imparting this phenotype. As such, this study presents one of the first examples in which cell-wide measurements have helped to elucidate the genetic and biochemical underpinnings of an engineered cellular property, leading to the total restoration of metabolite overproduction from specific chromosomal mutations.

  14. An Approach to Detect and Mitigate Ice Particle Accretion in Aircraft Engine Compression Systems

    Science.gov (United States)

    May, Ryan D.; Guo, Ten-Huei; Simon, Donald L.

    2013-01-01

    The accretion of ice in the compression system of commercial gas turbine engines operating in high ice water content conditions is a safety issue being studied by the aviation sector. While most of the research focuses on the underlying physics of ice accretion and the meteorological conditions in which accretion can occur, a systems-level perspective on the topic lends itself to potential near-term operational improvements. This work focuses on developing an accurate and reliable algorithm for detecting the accretion of ice in the low pressure compressor of a generic 40,000 lbf thrust class engine. The algorithm uses only the two shaft speed sensors and works regardless of engine age, operating condition, and power level. In a 10,000-case Monte Carlo simulation, the detection approach was found to have excellent capability at determining ice accretion from sensor noise with detection occurring when ice blocks an average of 6.8% of the low pressure compressor area. Finally, an initial study highlights a potential mitigation strategy that uses the existing engine actuators to raise the temperature in the low pressure compressor in an effort to reduce the rate at which ice accretes.

  15. Deformation and fracture of solid-state materials field theoretical approach and engineering applications

    CERN Document Server

    Yoshida, Sanichiro

    2015-01-01

    This book introduces a comprehensive theory of deformation and fracture to engineers and applied scientists. The author explains the gist of local symmetry (gauge invariance) intuitively so that engineers and applied physicists can digest it easily, rather than describing physical or mathematical details of the principle. Applications of the theory to practical engineering are also described, such as nondestructive testing, in particular, with the use of an optical interferometric technique called ESPI (Electronic Speckle-Pattern Interferometry). The book provides information on how to apply physical concepts to engineering applications. This book also: ·         Describes a highly original way to reveal loading hysteresis of a given specimen ·         Presents a fundamentally new approach to deformation and fracture, which offers potential for new applications ·         Introduces the unique application of Electric Speckle-Pattern Interferometry—reading fringe patterns to connect...

  16. Developing a Clinically Relevant Tissue Engineered Heart Valve-A Review of Current Approaches.

    Science.gov (United States)

    Nachlas, Aline L Y; Li, Siyi; Davis, Michael E

    2017-12-01

    Tissue engineered heart valves (TEHVs) have the potential to address the shortcomings of current implants through the combination of cells and bioactive biomaterials that promote growth and proper mechanical function in physiological conditions. The ideal TEHV should be anti-thrombogenic, biocompatible, durable, and resistant to calcification, and should exhibit a physiological hemodynamic profile. In addition, TEHVs may possess the capability to integrate and grow with somatic growth, eliminating the need for multiple surgeries children must undergo. Thus, this review assesses clinically available heart valve prostheses, outlines the design criteria for developing a heart valve, and evaluates three types of biomaterials (decellularized, natural, and synthetic) for tissue engineering heart valves. While significant progress has been made in biomaterials and fabrication techniques, a viable tissue engineered heart valve has yet to be translated into a clinical product. Thus, current strategies and future perspectives are also discussed to facilitate the development of new approaches and considerations for heart valve tissue engineering. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Reverse engineering of a railcar prototype via energetic macroscopic representation approach

    International Nuclear Information System (INIS)

    Agbli, Kréhi Serge; Hissel, Daniel; Sorrentino, Marco; Chauvet, Frédéric; Pouget, Julien

    2016-01-01

    Highlights: • A complex EMR model of a new railcar range has been developed. • A satisfactory assessment of the fuel consumption of the railcar. • The significant potential benefits are attainable by hybridizing the original railcar. • The regenerative braking can provide up to 240 kW h saving. - Abstract: Energetic Macroscopic Representation (EMR) modelling approach is proposed to perform model-based reverse-engineering of a new railcar range, having six propulsion units, each consisting of a diesel engine and a traction motor. Particularly, EMR intrinsic features were exploited to perform phenomenological structuration of power flows, thus allowing proper and comprehensive modelling of complex systems, such as the under-study railcar. Based on some prospective real trips, selected in such a way as to enable realistic evaluation of effective railcar effort, EMR-based prediction of railcar energy consumption is performed. Furthermore, physical consistency of each powertrain component operation was carefully verified. The suitability of EMR approach was thus proven effective to perform reverse-engineering of known specifications and available experimental data, with the final aim of reconstructing a high fidelity computational tool that meets computational burden requirements for subsequent model-based tasks deployment. Finally, specific simulation analyses were performed to evaluate the potential benefits attainable through electric hybridization of the original powertrain.

  18. Improvement of pristinamycin I (PI) production inStreptomyces pristinaespiralisby metabolic engineering approaches.

    Science.gov (United States)

    Meng, Jiali; Feng, Rongrong; Zheng, Guosong; Ge, Mei; Mast, Yvonne; Wohlleben, Wolfgang; Gao, Jufang; Jiang, Weihong; Lu, Yinhua

    2017-06-01

    Pristinamycin, produced by Streptomyces pristinaespiralis , which is a streptogramin-like antibiotic consisting of two chemically unrelated components: pristinamycin I (PI) and pristinamycin II (PII), shows potent activity against many antibiotic-resistant pathogens. However, so far pristinamycin production titers are still quite low, particularly those of PI. In this study, we constructed a PI single component producing strain by deleting the PII biosynthetic genes ( snaE1 and snaE2 ). Then, two metabolic engineering approaches, including deletion of the repressor gene papR3 and chromosomal integration of an extra copy of the PI biosynthetic gene cluster (BGC), were employed to improve PI production. The final engineered strain ΔPIIΔ papR3 /PI produced a maximum PI level of 132 mg/L, with an approximately 2.4-fold higher than that of the parental strain S. pristinaespiralis HCCB10218. Considering that the PI biosynthetic genes are clustered in two main regions in the 210 kb "supercluster" containing the PI and PII biosynthetic genes as well as a cryptic polyketide BGC, these two regions were cloned separately and then were successfully assembled into the PI BGC by the transformation-associated recombination (TAR) system. Collectively, the metabolic engineering approaches employed is very efficient for strain improvement in order to enhance PI titer.

  19. Dispatch of distributed energy resources to provide energy and reserve in smart grids using a particle swarm optimization approach

    DEFF Research Database (Denmark)

    Faria, Pedro; Soares, Tiago; Pinto, Tiago

    2013-01-01

    grid operation. Computational intelligence methods can be used to give a suitable solution for the resources scheduling problem considering the time constraints. This paper proposes a methodology for a joint dispatch of demand response and distributed generation to provide energy and reserve...... are recognized. The increasing integration of demand response and distributed generation resources, all of them mostly with small scale distributed characteristics, leads to the need of aggregating entities such as Virtual Power Players. The operation business models become more complex in the context of smart...

  20. Non-Genetic Engineering Approaches for Isolating and Generating Novel Yeasts for Industrial Applications

    Science.gov (United States)

    Chambers, P. J.; Bellon, J. R.; Schmidt, S. A.; Varela, C.; Pretorius, I. S.

    Generating novel yeast strains for industrial applications should be quite straightforward; after all, research into the genetics, biochemistry and physiology of Baker's Yeast, Saccharomyces cerevisiae, has paved the way for many advances in the modern biological sciences. We probably know more about this humble eukaryote than any other, and it is the most tractable of organisms for manipulation using modern genetic engineering approaches. In many countries, however, there are restrictions on the use of genetically-modified organisms (GMOs), particularly in foods and beverages, and the level of consumer acceptance of GMOs is, at best, variable. Thus, many researchers working with industrial yeasts use genetic engineering techniques primarily as research tools, and strain development continues to rely on non-GM technologies. This chapter explores the non-GM tools and strategies available to such researchers.

  1. Growth factor delivery-based tissue engineering: general approaches and a review of recent developments.

    Science.gov (United States)

    Lee, Kangwon; Silva, Eduardo A; Mooney, David J

    2011-02-06

    The identification and production of recombinant morphogens and growth factors that play key roles in tissue regeneration have generated much enthusiasm and numerous clinical trials, but the results of many of these trials have been largely disappointing. Interestingly, the trials that have shown benefit all contain a common denominator, the presence of a material carrier, suggesting strongly that spatio-temporal control over the location and bioactivity of factors after introduction into the body is crucial to achieve tangible therapeutic effect. Sophisticated materials systems that regulate the biological presentation of growth factors represent an attractive new generation of therapeutic agents for the treatment of a wide variety of diseases. This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives are discussed. Recent progress highlights the importance of materials science and engineering in growth factor delivery approaches to regenerative medicine.

  2. An approach to evaluating system well-being in engineering reliability applications

    International Nuclear Information System (INIS)

    Billinton, Roy; Fotuhi-Firuzabad, Mahmud; Aboreshaid, Saleh

    1995-01-01

    This paper presents an approach to evaluating the degree of system well-being of an engineering system. The functionality of the system is identified by healthy, marginal and risk states. The state definitions permit the inclusion of deterministic considerations in the probabilistic indices used to monitor the system well-being. A technique is developed to determine the three operating state probabilities based on minimal path concepts. The identified indices provide system engineers with additional information on the degree of system well-being in the form of system health and margin state probabilities. A basic planning objective should be to design a system such that the probabilities of the health and risk states are acceptable. The application of the technique is illustrated in this paper using a relatively simple network

  3. Software engineering techniques applied to agricultural systems an object-oriented and UML approach

    CERN Document Server

    Papajorgji, Petraq J

    2014-01-01

    Software Engineering Techniques Applied to Agricultural Systems presents cutting-edge software engineering techniques for designing and implementing better agricultural software systems based on the object-oriented paradigm and the Unified Modeling Language (UML). The focus is on the presentation of  rigorous step-by-step approaches for modeling flexible agricultural and environmental systems, starting with a conceptual diagram representing elements of the system and their relationships. Furthermore, diagrams such as sequential and collaboration diagrams are used to explain the dynamic and static aspects of the software system.    This second edition includes: a new chapter on Object Constraint Language (OCL), a new section dedicated to the Model-VIEW-Controller (MVC) design pattern, new chapters presenting details of two MDA-based tools – the Virtual Enterprise and Olivia Nova, and a new chapter with exercises on conceptual modeling.  It may be highly useful to undergraduate and graduate students as t...

  4. Genome-wide analytical approaches for reverse metabolic engineering of industrially relevant phenotypes in yeast

    Science.gov (United States)

    Oud, Bart; Maris, Antonius J A; Daran, Jean-Marc; Pronk, Jack T

    2012-01-01

    Successful reverse engineering of mutants that have been obtained by nontargeted strain improvement has long presented a major challenge in yeast biotechnology. This paper reviews the use of genome-wide approaches for analysis of Saccharomyces cerevisiae strains originating from evolutionary engineering or random mutagenesis. On the basis of an evaluation of the strengths and weaknesses of different methods, we conclude that for the initial identification of relevant genetic changes, whole genome sequencing is superior to other analytical techniques, such as transcriptome, metabolome, proteome, or array-based genome analysis. Key advantages of this technique over gene expression analysis include the independency of genome sequences on experimental context and the possibility to directly and precisely reproduce the identified changes in naive strains. The predictive value of genome-wide analysis of strains with industrially relevant characteristics can be further improved by classical genetics or simultaneous analysis of strains derived from parallel, independent strain improvement lineages. PMID:22152095

  5. An energy systems engineering approach to the optimal design of energy systems in commercial buildings

    International Nuclear Information System (INIS)

    Liu Pei; Pistikopoulos, Efstratios N.; Li Zheng

    2010-01-01

    Energy consumption in commercial buildings accounts for a significant proportion of worldwide energy consumption. Any increase in the energy efficiency of the energy systems for commercial buildings would lead to significant energy savings and emissions reductions. In this work, we introduce an energy systems engineering framework towards the optimal design of such energy systems with improved energy efficiency and environmental performance. The framework features a superstructure representation of the various energy technology alternatives, a mixed-integer optimization formulation of the energy systems design problem, and a multi-objective design optimization solution strategy, where economic and environmental criteria are simultaneously considered and properly traded off. A case study of a supermarket energy systems design is presented to illustrate the key steps and potential of the proposed energy systems engineering approach.

  6. An Approach to Developing Independent Learning and Non-Technical Skills Amongst Final Year Mining Engineering Students

    Science.gov (United States)

    Knobbs, C. G.; Grayson, D. J.

    2012-01-01

    There is mounting evidence to show that engineers need more than technical skills to succeed in industry. This paper describes a curriculum innovation in which so-called "soft" skills, specifically inter-personal and intra-personal skills, were integrated into a final year mining engineering course. The instructional approach was…

  7. Providing Formative Assessment to Students Solving Multipath Engineering Problems with Complex Arrangements of Interacting Parts: An Intelligent Tutor Approach

    Science.gov (United States)

    Steif, Paul S.; Fu, Luoting; Kara, Levent Burak

    2016-01-01

    Problems faced by engineering students involve multiple pathways to solution. Students rarely receive effective formative feedback on handwritten homework. This paper examines the potential for computer-based formative assessment of student solutions to multipath engineering problems. In particular, an intelligent tutor approach is adopted and…

  8. Morehouse Physics & Dual Degree Engineering Program: We C . A . R . E . Approach

    Science.gov (United States)

    Rockward, Willie S.

    2015-03-01

    Growing the physics major at any undergraduate institution, especially Morehouse College - a private, all-male, liberal arts HBCU, can be very challenging. To address this challenge at Morehouse, the faculty and staff in the Department of Physics and Dual Degree Engineering Program (Physics & DDEP) are applying a methodology and pedagogical approach called ``We C . A . R . E '' which stands for Curriculum,Advisement,Recruitment/Retention/Research, andExtras. This approach utilizes an integrated strategy of cultural (family-orientated), collaborative (shared-governance), and career (personalized-pathways) modalities to provide the momentum of growing the physics major at Morehouse from 10-12 students to over 100 students in less than 5 years. Physics & DDEP at Morehouse, creatively, altered faculty course assignments, curriculum offerings, and departmental policies while expanding research projects, student organizations, and external collaborations. This method supplies a variety of meaningful, academic and research experiences for undergraduates at Morehouse and thoroughly prepares students for graduate studies or professional careers in STEM disciplines. Thus, a detailed overview of the ``We C . A . R . E . '' approach will be presented along with the Physics & DDEP vision, alterations and expansions in growing the physics major at Morehouse College. Department of Physics and Dual Degree Engineering Program, Atlanta, Georgia 30314.

  9. A structured approach for the engineering of biochemical network models, illustrated for signalling pathways.

    Science.gov (United States)

    Breitling, Rainer; Gilbert, David; Heiner, Monika; Orton, Richard

    2008-09-01

    Quantitative models of biochemical networks (signal transduction cascades, metabolic pathways, gene regulatory circuits) are a central component of modern systems biology. Building and managing these complex models is a major challenge that can benefit from the application of formal methods adopted from theoretical computing science. Here we provide a general introduction to the field of formal modelling, which emphasizes the intuitive biochemical basis of the modelling process, but is also accessible for an audience with a background in computing science and/or model engineering. We show how signal transduction cascades can be modelled in a modular fashion, using both a qualitative approach--qualitative Petri nets, and quantitative approaches--continuous Petri nets and ordinary differential equations (ODEs). We review the major elementary building blocks of a cellular signalling model, discuss which critical design decisions have to be made during model building, and present a number of novel computational tools that can help to explore alternative modular models in an easy and intuitive manner. These tools, which are based on Petri net theory, offer convenient ways of composing hierarchical ODE models, and permit a qualitative analysis of their behaviour. We illustrate the central concepts using signal transduction as our main example. The ultimate aim is to introduce a general approach that provides the foundations for a structured formal engineering of large-scale models of biochemical networks.

  10. Methodologic model to scheduling on service systems: a software engineering approach

    Directory of Open Access Journals (Sweden)

    Eduyn Ramiro Lopez-Santana

    2016-06-01

    Full Text Available This paper presents an approach of software engineering to a research proposal to make an Expert System to scheduling on service systems using methodologies and processes of software development. We use the adaptive software development as methodology for the software architecture based on the description as a software metaprocess that characterizes the research process. We make UML’s diagrams (Unified Modeling Language to provide a visual modeling that describes the research methodology in order to identify the actors, elements and interactions in the research process.

  11. Molecular Approach to Microbiological Examination of Water Quality in the Grand Bay National Estuarine Research Reserve (NERR) in Mississippi, USA

    Science.gov (United States)

    Kishinhi, Stephen S.; Tchounwou, Paul B.; Farah, Ibrahim O.

    2013-01-01

    Grand Bay National Estuarine Research Reserve (NERR) is an important ecosystem in the Mississippi Gulf Coast. It serves as important nursery areas for juveniles of many species of fish. The bay is also used for fishing, crabbing, oyster togging, boating as well as recreation. Like in other aquatic environments, this bay may be contaminated by microorganisms including pathogenic bacteria. The objective of this study was to evaluate the microbiological quality of water in the Grand Bay NERR and determine the levels and potential source(s) of human fecal pollution. To achieve this goal, water samples were collected aseptically every month in Bayou Heron, Bayou Cumbest, Point Aux Chenes Bay and Bangs Lake. Enterococci were concentrated from water samples by membrane filtration according to the methodology outlined in USEPA Method 1600. After incubation, DNA was extracted from bacteria colonies on the membrane filters by using QIAamp DNA extraction kit. Water samples were also tested for the presence of traditional indicator bacteria including: heterotrophic plate count, total coliforms, fecal coliforms, and Enterococcus bacteria. The marker esp gene was detected in one site of Bayou Cumbest, an area where human populations reside. Data from this study indicates higher concentrations of indicator bacteria compared to the recommended acceptable levels. Presence of esp marker and high numbers of indicator bacteria suggest a public health concern for shellfish and water contact activities. Hence, control strategies should be developed and implemented to prevent further contamination of the Grand bay NERR waters. PMID:23761974

  12. Conventional and Indigenous Biodiversity Conservation Approach: A Comparative Study of Jachie Sacred Grove and Nkrabea Forest Reserve

    Directory of Open Access Journals (Sweden)

    Samuel Boadi

    2017-01-01

    Full Text Available Conventional managed forests and sacred groves are seldom assessed to determine their effectiveness in biodiversity conservation strategies. This study investigated tree and insect diversity in Jachie sacred grove (JSG and Nkrabea forest reserve (NFR in Ashanti region, Ghana. The study area constituted eight plots of 50 × 50 m along two 300 m long transects. Insects were sampled in eight pitfall traps, diagonally between the transects. Out of 150 individuals, 13 species in NFR and 15 species from JSG were registered. Celtis mildbraedii was the most dominant species in NFR = 43.18% and JSG = 23.58%. Mean DBH showed a significant relationship with basal area in NFR and JSG. Tree diversity and richness were higher in JSG (H′ = 1.43–2.3 ± 0.10; D = 1.8–3.69 ± 0.30 compared to NFR (H′ = 0.86–1.56 ± 0.09; D = 1.1–2.3 ± 0.57. However, insect diversity was higher in NFR (H′ = 1.34 ± 0.10 than in JSG (H′ = 0.5 ± 0.005. Camponotus furvus and Pachycondyla tarsata were most abundant in JSG and NFR, respectively. These findings will help conservationists work closely with traditional authorities in protecting sacred groves as key biodiversity hotspots.

  13. Model-based system engineering approach for the Euclid mission to manage scientific and technical complexity

    Science.gov (United States)

    Lorenzo Alvarez, Jose; Metselaar, Harold; Amiaux, Jerome; Saavedra Criado, Gonzalo; Gaspar Venancio, Luis M.; Salvignol, Jean-Christophe; Laureijs, René J.; Vavrek, Roland

    2016-08-01

    In the last years, the system engineering field is coming to terms with a paradigm change in the approach for complexity management. Different strategies have been proposed to cope with highly interrelated systems, system of systems and collaborative system engineering have been proposed and a significant effort is being invested into standardization and ontology definition. In particular, Model Based System Engineering (MBSE) intends to introduce methodologies for a systematic system definition, development, validation, deployment, operation and decommission, based on logical and visual relationship mapping, rather than traditional 'document based' information management. The practical implementation in real large-scale projects is not uniform across fields. In space science missions, the usage has been limited to subsystems or sample projects with modeling being performed 'a-posteriori' in many instances. The main hurdle for the introduction of MBSE practices in new projects is still the difficulty to demonstrate their added value to a project and whether their benefit is commensurate with the level of effort required to put them in place. In this paper we present the implemented Euclid system modeling activities, and an analysis of the benefits and limitations identified to support in particular requirement break-down and allocation, and verification planning at mission level.

  14. Transforming Benzophenoxazine Laser Dyes into Chromophores for Dye-Sensitized Solar Cells: A Molecular Engineering Approach

    Energy Technology Data Exchange (ETDEWEB)

    Schröder, Florian A. Y. N. [Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue Cambridge CB3 0HE UK; Cole, Jacqueline M. [Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue Cambridge CB3 0HE UK; Argonne National Laboratory, 9700 S. Cass Avenue Argonne IL 60439 USA; International Institute for Complex Adaptive Matter, University of California Davis, Davis CA 95616 USA; Waddell, Paul G. [Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue Cambridge CB3 0HE UK; Australian Nuclear Science and Technology Organization, Lucas Heights, New South Wales 2234 Australia; McKechnie, Scott [Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue Cambridge CB3 0HE UK

    2015-02-03

    The re-functionalization of a series of four well-known industrial laser dyes, based on benzophenoxazine, is explored with the prospect of molecularly engineering new chromophores for dye-sensitized solar cell (DSC) applications. Such engineering is important since a lack of suitable dyes is stifling the progress of DSC technology. The conceptual idea involves making laser dyes DSC-active by chemical modification, while maintaining their key property attributes that are attractive to DSC applications. This molecular engineering follows a step-wise approach. Firstly, molecular structures and optical absorption properties are determined for the parent laser dyes: Cresyl Violet (1); Oxazine 170 (2); Nile Blue A (3), Oxazine 750 (4). These reveal structure-property relationships which define the prerequisites for computational molecular design of DSC dyes; the nature of their molecular architecture (D-π-A) and intramolecular charge transfer. Secondly, new DSC dyes are computationally designed by the in silico addition of a carboxylic acid anchor at various chemical substitution points in the parent laser dyes. A comparison of the resulting frontier molecular orbital energy levels with the conduction band edge of a TiO2 DSC photoanode and the redox potential of two electrolyte options I-/I3- and Co(II/III)tris(bipyridyl) suggests promise for these computationally designed dyes as co-sensitizers for DSC applications.

  15. V&V Plan for FPGA-based ESF-CCS Using System Engineering Approach.

    Science.gov (United States)

    Maerani, Restu; Mayaka, Joyce; El Akrat, Mohamed; Cheon, Jung Jae

    2018-02-01

    Instrumentation and Control (I&C) systems play an important role in maintaining the safety of Nuclear Power Plant (NPP) operation. However, most current I&C safety systems are based on Programmable Logic Controller (PLC) hardware, which is difficult to verify and validate, and is susceptible to software common cause failure. Therefore, a plan for the replacement of the PLC-based safety systems, such as the Engineered Safety Feature - Component Control System (ESF-CCS), with Field Programmable Gate Arrays (FPGA) is needed. By using a systems engineering approach, which ensures traceability in every phase of the life cycle, from system requirements, design implementation to verification and validation, the system development is guaranteed to be in line with the regulatory requirements. The Verification process will ensure that the customer and stakeholder’s needs are satisfied in a high quality, trustworthy, cost efficient and schedule compliant manner throughout a system’s entire life cycle. The benefit of the V&V plan is to ensure that the FPGA based ESF-CCS is correctly built, and to ensure that the measurement of performance indicators has positive feedback that “do we do the right thing” during the re-engineering process of the FPGA based ESF-CCS.

  16. Combined analytical and numerical approaches in Dynamic Stability analyses of engineering systems

    Science.gov (United States)

    Náprstek, Jiří

    2015-03-01

    Dynamic Stability is a widely studied area that has attracted many researchers from various disciplines. Although Dynamic Stability is usually associated with mechanics, theoretical physics or other natural and technical disciplines, it is also relevant to social, economic, and philosophical areas of our lives. Therefore, it is useful to occasionally highlight the general aspects of this amazing area, to present some relevant examples and to evaluate its position among the various branches of Rational Mechanics. From this perspective, the aim of this study is to present a brief review concerning the Dynamic Stability problem, its basic definitions and principles, important phenomena, research motivations and applications in engineering. The relationships with relevant systems that are prone to stability loss (encountered in other areas such as physics, other natural sciences and engineering) are also noted. The theoretical background, which is applicable to many disciplines, is presented. In this paper, the most frequently used Dynamic Stability analysis methods are presented in relation to individual dynamic systems that are widely discussed in various engineering branches. In particular, the Lyapunov function and exponent procedures, Routh-Hurwitz, Liénard, and other theorems are outlined together with demonstrations. The possibilities for analytical and numerical procedures are mentioned together with possible feedback from experimental research and testing. The strengths and shortcomings of these approaches are evaluated together with examples of their effective complementing of each other. The systems that are widely encountered in engineering are presented in the form of mathematical models. The analyses of their Dynamic Stability and post-critical behaviour are also presented. The stability limits, bifurcation points, quasi-periodic response processes and chaotic regimes are discussed. The limit cycle existence and stability are examined together with their

  17. A top-down approach in control engineering third-level teaching: The case of hydrogen-generation

    Science.gov (United States)

    Setiawan, Eko; Habibi, M. Afnan; Fall, Cheikh; Hodaka, Ichijo

    2017-09-01

    This paper presents a top-down approach in control engineering third-level teaching. The paper shows the control engineering solution for the issue of practical implementation in order to motivate students. The proposed strategy only focuses on one technique of control engineering to lead student correctly. The proposed teaching steps are 1) defining the problem, 2) listing of acquired knowledge or required skill, 3) selecting of one control engineering technique, 4) arrangement the order of teaching: problem introduction, implementation of control engineering technique, explanation of system block diagram, model derivation, controller design, and 5) enrichment knowledge by the other control techniques. The approach presented highlights hardware implementation and the use of software simulation as a self-learning tool for students.

  18. A Survey of Automatic Protocol Reverse Engineering Approaches, Methods, and Tools on the Inputs and Outputs View

    Directory of Open Access Journals (Sweden)

    Baraka D. Sija

    2018-01-01

    Full Text Available A network protocol defines rules that control communications between two or more machines on the Internet, whereas Automatic Protocol Reverse Engineering (APRE defines the way of extracting the structure of a network protocol without accessing its specifications. Enough knowledge on undocumented protocols is essential for security purposes, network policy implementation, and management of network resources. This paper reviews and analyzes a total of 39 approaches, methods, and tools towards Protocol Reverse Engineering (PRE and classifies them into four divisions, approaches that reverse engineer protocol finite state machines, protocol formats, and both protocol finite state machines and protocol formats to approaches that focus directly on neither reverse engineering protocol formats nor protocol finite state machines. The efficiency of all approaches’ outputs based on their selected inputs is analyzed in general along with appropriate reverse engineering inputs format. Additionally, we present discussion and extended classification in terms of automated to manual approaches, known and novel categories of reverse engineered protocols, and a literature of reverse engineered protocols in relation to the seven layers’ OSI (Open Systems Interconnection model.

  19. The Evaluation of Industry Practical of Mechanical Engineering in Vocational Education: A CIPP Model Approach

    Science.gov (United States)

    Kamaludin, M.; Munawar, W.; Mahdan, D.; Simanjuntak, M. V.; Wendi, H. F.

    2018-02-01

    The learning system is not only studied on campus but also practicing in the world of work. Industry Practical aims to enable students to develop their skills in accordance with the real world of work. To know the success of the implementation of industry practical program then held evaluation. The evaluation of the program in this study used the CIPP evaluation approach (Context, Input, Process, Product). The purpose of this research is to know the extent of achievement and success of industry practical program at vocational school in Bandung with descriptive research method using mix method approach. The sample in this research is students majoring in mechanical engineering in the city of Bandung who have done industry practical.

  20. Improving Knowledge Management in the Health Service: Re-Engineering Approach Towards Successful Implementation

    Science.gov (United States)

    Gyampoh-Vidogah, Regina; Moreton, Robert

    Changes to business practices involve risks. There has always been an attempt to develop various concepts for successful restructuring of business processes to enable technology adoption. This is due to the fact that the success of any business depends as much on how it is structured, as well as its ability to adopt new technology. As a consequence, the great success stories of the global economy emanate from those organisations most capable of adopting new technology, which invariably includes information technology (IT). This chapter examines how business process re-engineering (BPR) can be used to improve knowledge management (KM) in health services by (i) assessing the effectiveness and usefulness of BPR; (ii) present a critical review of approaches to BPR; and (iii) describe a framework for using BPR for KM based on empirical research. The aim is to provide a sound strategic and tactical management approach for successful implementation of knowledge management systems (KMS) to improve health-care service project administration.

  1. A Model-Free Diagnosis Approach for Intake Leakage Detection and Characterization in Diesel Engines

    Directory of Open Access Journals (Sweden)

    Ghaleb Hoblos

    2015-07-01

    Full Text Available Feature selection is an essential step for data classification used in fault detection and diagnosis processes. In this work, a new approach is proposed, which combines a feature selection algorithm and a neural network tool for leak detection and characterization tasks in diesel engine air paths. The Chi square classifier is used as the feature selection algorithm and the neural network based on Levenberg-Marquardt is used in system behavior modeling. The obtained neural network is used for leak detection and characterization. The model is learned and validated using data generated by xMOD. This tool is used again for testing. The effectiveness of the proposed approach is illustrated in simulation when the system operates on a low speed/load and the considered leak affecting the air path is very small.

  2. An efficient approach to unstructured mesh hydrodynamics on the cell broadband engine (u)

    Energy Technology Data Exchange (ETDEWEB)

    Ferenbaugh, Charles R [Los Alamos National Laboratory

    2010-12-14

    Unstructured mesh physics for the Cell Broadband Engine (CBE) has received little or no attention to date, largely because the CBE architecture poses particular challenges for unstructured mesh algorithms. SPU memory management strategies such as data preloading cannot be applied to the irregular memory storage patterns of unstructured meshes; and the SPU vector instruction set does not support the indirect addressing needed by connectivity arrays. This paper presents an approach to unstructured mesh physics that addresses these challenges, by creating a new mesh data structure and reorganizing code to give efficient CBE performance. The approach is demonstrated on the FLAG production hydrodynamics code using standard test problems, and results show an average speedup of more than 5x over the original code.

  3. An efficient approach to unstructured mesh hydrodynamics on the cell broadband engine

    Energy Technology Data Exchange (ETDEWEB)

    Ferenbaugh, Charles R [Los Alamos National Laboratory

    2010-01-01

    Unstructured mesh physics for the Cell Broadband Engine (CBE) has received little or no attention to date, largely because the CBE architecture poses particular challenges for unstructured mesh algorithms. The most common SPU memory management strategies cannot be applied to the irregular memory access patterns of unstructured meshes, and the SPU vector instruction set does not support the indirect addressing needed by connectivity arrays. This paper presents an approach to unstructured mesh physics that addresses these challenges, by creating a new mesh data structure and reorganizing code to give efficient CBE performance. The approach is demonstrated on the FLAG production hydrodynamics code using standard test problems, and results show an average speedup of more than 5x over the original code.

  4. E-learning and blended learning in textile engineering education: a closed feedback loop approach

    Science.gov (United States)

    Charitopoulos, A.; Vassiliadis, S.; Rangoussi, M.; Koulouriotis, D.

    2017-10-01

    E-learning has gained a significant role in typical education and in professional training, thanks to the flexibility it offers to the time and location parameters of the education event framework. Purely e-learning scenarios are mostly limited either to Open University-type higher education institutions or to graduate level or professional degrees; blended learning scenarios are progressively becoming popular thanks to their balanced approach. The aim of the present work is to propose approaches that exploit the e-learning and the blended-learning scenarios for Textile Engineering education programmes, especially for multi-institutional ones. The “E-Team” European MSc degree programme organized by AUTEX is used as a case study. The proposed solution is based on (i) a free and open-source e-learning platform (moodle) and (ii) blended learning educational scenarios. Educational challenges addressed include student engagement, student error / failure handling, as well as collaborative learning promotion and support.

  5. Green Materials Science and Engineering Reduces Biofouling: Approaches for Medical and Membrane-based Technologies

    Directory of Open Access Journals (Sweden)

    Kerianne M Dobosz

    2015-03-01

    Full Text Available Numerous engineered and natural environments suffer deleterious effects from biofouling and/or biofilm formation. For instance, bacterial contamination on biomedical devices pose serious health concerns. In membrane-based technologies, such as desalination and wastewater reuse, biofouling decreases membrane lifetime and increases the energy required to produce clean water. Traditionally, approaches have combatted bacteria using bactericidal agents. However, due to globalization, a decline in antibiotic discovery, and the widespread resistance of microbes to many commercial antibiotics and metallic nanoparticles, new materials and approaches to reduce biofilm formation are needed. In this mini-review, we cover the recent strategies that have been explored to combat microbial contamination without exerting evolutionary pressure on microorganisms. Renewable feedstocks, relying on structure-property relationships, bioinspired/nature-derived compounds, and green processing methods are discussed. Greener strategies that mitigate biofouling hold great potential to positively impact human health and safety.

  6. Vibration Monitoring of Gas Turbine Engines: Machine-Learning Approaches and Their Challenges

    Directory of Open Access Journals (Sweden)

    Ioannis Matthaiou

    2017-09-01

    Full Text Available In this study, condition monitoring strategies are examined for gas turbine engines using vibration data. The focus is on data-driven approaches, for this reason a novelty detection framework is considered for the development of reliable data-driven models that can describe the underlying relationships of the processes taking place during an engine’s operation. From a data analysis perspective, the high dimensionality of features extracted and the data complexity are two problems that need to be dealt with throughout analyses of this type. The latter refers to the fact that the healthy engine state data can be non-stationary. To address this, the implementation of the wavelet transform is examined to get a set of features from vibration signals that describe the non-stationary parts. The problem of high dimensionality of the features is addressed by “compressing” them using the kernel principal component analysis so that more meaningful, lower-dimensional features can be used to train the pattern recognition algorithms. For feature discrimination, a novelty detection scheme that is based on the one-class support vector machine (OCSVM algorithm is chosen for investigation. The main advantage, when compared to other pattern recognition algorithms, is that the learning problem is being cast as a quadratic program. The developed condition monitoring strategy can be applied for detecting excessive vibration levels that can lead to engine component failure. Here, we demonstrate its performance on vibration data from an experimental gas turbine engine operating on different conditions. Engine vibration data that are designated as belonging to the engine’s “normal” condition correspond to fuels and air-to-fuel ratio combinations, in which the engine experienced low levels of vibration. Results demonstrate that such novelty detection schemes can achieve a satisfactory validation accuracy through appropriate selection of two parameters of the

  7. Evaluation of Some Physiochemical Parameters and Heavy Metal Contamination in Hara Biosphere Reserve, Iran, Using a New Pollution Index Approach

    Directory of Open Access Journals (Sweden)

    Iman Zarei

    2016-07-01

    Full Text Available Background: The pollution of the aquatic environment with heavy metals has become a worldwide problem during recent years, due to their potential toxic effects and ability to bio-accumulate in aquatic ecosystems. Heavy metals are sensitive indicators for monitoring changes in the aquatic environment. Methods: In this study, total concentrations of Cr, Pb, Cu, Zn, and Fe were measured in water and sediments from nine sites, based on ecological conditions and human activities and the effects of sediment pH and sediment organic matter on bioavailability of selected metals were determined. Modified degree of contamination (mCd was computed in order to determine anthropogenically derived sediment contamination. Results: Mean concentration of metals in water found to be in the following order: Pb > Fe > Zn > Cu > Cr, while in sediment samples it was Fe > Cr > Zn > Pb > Cu. The average content of examined metals in water was higher than the chronic values in marine surface water guideline values. Mean content of Cr, Pb and Fe in sediments were higher than average of the less contaminated sample but Cu and Zn were lower than this guideline value. In the study area, mCd values were less than 1.5 with values ranging from 0.71 to 1.02. Conclusion: The results of this study indicated with a decrease in organic matter and pH in sediments, the concentration of copper and iron increased. Base on modified contamination degree, the sediments of Hara Biosphere Reserve are considered to be in the zero to very low contamination status.

  8. A system-of-systems approach as a broad and integrated paradigm for sustainable engineered nanomaterials.

    Science.gov (United States)

    Tolaymat, Thabet; El Badawy, Amro; Sequeira, Reynold; Genaidy, Ash

    2015-04-01

    There is an urgent need for a trans-disciplinary approach for the collective evaluation of engineered nanomaterial (ENM) benefits and risks. Currently, research studies are mostly focused on examining effects at individual endpoints with emphasis on ENM risk effects. Less research work is pursuing the integration needed to advance the science of sustainable ENMs. Therefore, the primary objective of this article is to discuss the system-of-systems (SoS) approach as a broad and integrated paradigm to examine ENM benefits and risks to society, environment, and economy (SEE) within a sustainability context. The aims are focused on: (a) current approaches in the scientific literature and the need for a broad and integrated approach, (b) documentation of ENM SoS in terms of architecture and governing rules and practices within sustainability context, and (c) implementation plan for the road ahead. In essence, the SoS architecture is a communication vehicle offering the opportunity to track benefits and risks in an integrated fashion so as to understand the implications and make decisions about advancing the science of sustainable ENMs. In support of the SoS architecture, we propose using an analytic-based decision support system consisting of a knowledge base and analytic engine along the benefit and risk informatics routes in the SEE system to build sound decisions on what constitutes sustainable and unsustainable ENMs in spite of the existing uncertainties and knowledge gaps. The work presented herein is neither a systematic review nor a critical appraisal of the scientific literature. Rather, it is a position paper that largely expresses the views of the authors based on their expert opinion drawn from industrial and academic experience. Copyright © 2014. Published by Elsevier B.V.

  9. An Architecture, System Engineering, and Acquisition Approach for Space System Software Resiliency

    Science.gov (United States)

    Phillips, Dewanne Marie

    Software intensive space systems can harbor defects and vulnerabilities that may enable external adversaries or malicious insiders to disrupt or disable system functions, risking mission compromise or loss. Mitigating this risk demands a sustained focus on the security and resiliency of the system architecture including software, hardware, and other components. Robust software engineering practices contribute to the foundation of a resilient system so that the system "can take a hit to a critical component and recover in a known, bounded, and generally acceptable period of time". Software resiliency must be a priority and addressed early in the life cycle development to contribute a secure and dependable space system. Those who develop, implement, and operate software intensive space systems must determine the factors and systems engineering practices to address when investing in software resiliency. This dissertation offers methodical approaches for improving space system resiliency through software architecture design, system engineering, increased software security, thereby reducing the risk of latent software defects and vulnerabilities. By providing greater attention to the early life cycle phases of development, we can alter the engineering process to help detect, eliminate, and avoid vulnerabilities before space systems are delivered. To achieve this objective, this dissertation will identify knowledge, techniques, and tools that engineers and managers can utilize to help them recognize how vulnerabilities are produced and discovered so that they can learn to circumvent them in future efforts. We conducted a systematic review of existing architectural practices, standards, security and coding practices, various threats, defects, and vulnerabilities that impact space systems from hundreds of relevant publications and interviews of subject matter experts. We expanded on the system-level body of knowledge for resiliency and identified a new software

  10. Realization of a Brownian engine to study transport phenomena: a semiclassical approach.

    Science.gov (United States)

    Ghosh, Pradipta; Shit, Anindita; Chattopadhyay, Sudip; Chaudhuri, Jyotipratim Ray

    2010-06-01

    Brownian particles moving in a periodic potential with or without external load are often used as good theoretical models for the phenomenological studies of microscopic heat engines. The model that we propose here, assumes the particle to be moving in a nonequilibrium medium and we have obtained the exact expression for the stationary current density. We have restricted our consideration to the overdamped motion of the Brownian particle. We present here a self-consistent theory based on the system-reservoir coupling model, within a microscopic approach, of fluctuation induced transport in the semiclassical limit for a general system coupled with two heat baths kept at different temperatures. This essentially puts forth an approach to semiclassical state-dependent diffusion. We also explore the possibility of observing a current when the temperature of the two baths are different, and also envisage that our system may act as a Carnot engine even when the bath temperatures are the same. The condition for such a construction has been elucidated.

  11. Life Cycle Systems Engineering Approach to NASA's 2nd Generation Reusable Launch Vehicle

    Science.gov (United States)

    Thomas, Dale; Smith, Charles; Safie, Fayssal; Kittredge, Sheryl

    2002-01-01

    The overall goal of the 2nd Generation RLV Program is to substantially reduce technical and business risks associated with developing a new class of reusable launch vehicles. NASA's specific goals are to improve the safety of a 2nd- generation system by 2 orders of magnitude - equivalent to a crew risk of 1 -in- 10,000 missions - and decrease the cost tenfold, to approximately $1,000 per pound of payload launched. Architecture definition is being conducted in parallel with the maturating of key technologies specifically identified to improve safety and reliability, while reducing operational costs. An architecture broadly includes an Earth-to-orbit reusable launch vehicle, on-orbit transfer vehicles and upper stages, mission planning, ground and flight operations, and support infrastructure, both on the ground and in orbit. The systems engineering approach ensures that the technologies developed - such as lightweight structures, long-life rocket engines, reliable crew escape, and robust thermal protection systems - will synergistically integrate into the optimum vehicle. Given a candidate architecture that possesses credible physical processes and realistic technology assumptions, the next set of analyses address the system's functionality across the spread of operational scenarios characterized by the design reference missions. The safety/reliability and cost/economics associated with operating the system will also be modeled and analyzed to answer the questions "How safe is it?" and "How much will it cost to acquire and operate?" The systems engineering review process factors in comprehensive budget estimates, detailed project schedules, and business and performance plans, against the goals of safety, reliability, and cost, in addition to overall technical feasibility. This approach forms the basis for investment decisions in the 2nd Generation RLV Program's risk-reduction activities. Through this process, NASA will continually refine its specialized needs and

  12. Interface engineering: an effective approach toward high-performance organic field-effect transistors.

    Science.gov (United States)

    Di, Chong-an; Liu, Yunqi; Yu, Gui; Zhu, Daoben

    2009-10-20

    By virtue of their excellent solution processibility and flexibility, organic field-effect transistors (OFETs) are considered outstanding candidates for application in low-cost, flexible electronics. Not only does the performance of OFETs depend on the molecular properties of the organic semiconductors involved, but it is also dramatically affected by the nature of the interfaces present. Therefore, interface engineering, a novel approach towards high-performance OFETs, has attracted considerable attention. In this Account, we focus on recent advances in the study of OFET interfaces--including electrode/organic layer interfaces, dielectric/organic layer interfaces, and organic/organic layer interfaces--that have resulted in improved device performance, enhanced stability, and the realization of organic light-emitting transistors. The electrode/organic layer interface, one of the most important interfaces in OFETs, usually determines the carrier injection characteristics. Focusing on OFETs with copper and silver electrodes, we describe effective modification approaches of the electrode/organic layer interfaces. Furthermore, the influence of electrode morphology on device performance is demonstrated. These results provide novel approaches towards high-performance, low-cost OFETs. The dielectric/organic layer interface is a vital interface that dominates carrier transport; modification of this interface therefore offers a general way to improve carrier transport accordingly. The dielectric layer also affects the device stability of OFETs. For example, high-performance pentacene OFETs with excellent stability are obtained by the selection of a dielectric layer with an appropriate surface energy. The organic/organic layer interface is a newly investigated topic in OFETs. Introduction of organic/organic layer interfaces, such as heterojunctions, can improve device performance and afford ambipolar OFETs. By designing laterally arranged heterojunctions made of organic

  13. A gene stacking approach leads to engineered plants with highly increased galactan levels in Arabidopsis.

    Science.gov (United States)

    Gondolf, Vibe M; Stoppel, Rhea; Ebert, Berit; Rautengarten, Carsten; Liwanag, April Jm; Loqué, Dominique; Scheller, Henrik V

    2014-12-10

    Engineering of plants with a composition of lignocellulosic biomass that is more suitable for downstream processing is of high interest for next-generation biofuel production. Lignocellulosic biomass contains a high proportion of pentose residues, which are more difficult to convert into fuels than hexoses. Therefore, increasing the hexose/pentose ratio in biomass is one approach for biomass improvement. A genetic engineering approach was used to investigate whether the amount of pectic galactan can be specifically increased in cell walls of Arabidopsis fiber cells, which in turn could provide a potential source of readily fermentable galactose. First it was tested if overexpression of various plant UDP-glucose 4-epimerases (UGEs) could increase the availability of UDP-galactose and thereby increase the biosynthesis of galactan. Constitutive and tissue-specific expression of a poplar UGE and three Arabidopsis UGEs in Arabidopsis plants could not significantly increase the amount of cell wall bound galactose. We then investigated co-overexpression of AtUGE2 together with the β-1,4-galactan synthase GalS1. Co-overexpression of AtUGE2 and GalS1 led to over 80% increase in cell wall galactose levels in Arabidopsis stems, providing evidence that these proteins work synergistically. Furthermore, AtUGE2 and GalS1 overexpression in combination with overexpression of the NST1 master regulator for secondary cell wall biosynthesis resulted in increased thickness of fiber cell walls in addition to the high cell wall galactose levels. Immunofluorescence microscopy confirmed that the increased galactose was present as β-1,4-galactan in secondary cell walls. This approach clearly indicates that simultaneous overexpression of AtUGE2 and GalS1 increases the cell wall galactose to much higher levels than can be achieved by overexpressing either one of these proteins alone. Moreover, the increased galactan content in fiber cells while improving the biomass composition had no impact

  14. App Factory: A flexible approach to rehabilitation engineering in an era of rapid technology advancement.

    Science.gov (United States)

    Jones, Michael; Mueller, James; Morris, John

    2017-01-01

    This article describes a flexible and effective approach to research and development in an era of rapid technological advancement. The approach relies on secondary dispersal of grant funds to commercial developers through a competitive selection process. This "App Factory" model balances the practical reliance on multi-year funding needed to sustain a rehabilitation engineering research center (RERC), with the need for agility and adaptability of development efforts undertaken in a rapidly changing technology environment. This approach also allows us to take advantage of technical expertise needed to accomplish a particular development task, and provides incentives to deliver successful products in a cost-effective manner. In this article, we describe the App Factory structure, process, and results achieved to date; and we discuss the lessons learned and the potential relevance of this approach for other grant-funded research and development efforts. Data presented on the direct costs and number of downloads of the 16 app development projects funded in the App Factory's first 3 years show that it can be an effective means for supporting focused, short-term assistive technology development projects.

  15. Example of a Human Factors Engineering approach to a medication administration work system: potential impact on patient safety.

    Science.gov (United States)

    Beuscart-Zéphir, Marie-Catherine; Pelayo, Sylvia; Bernonville, Stéphanie

    2010-04-01

    The objectives of this paper are: In this approach, the implementation of such a complex IT solution is considered a major redesign of the work system. The paper describes the Human Factor (HF) tasks embedded in the project lifecycle: (1) analysis and modelling of the current work system and usability assessment of the medication CPOE solution; (2) HF recommendations for work re-design and usability recommendations for IT system re-engineering both aiming at a safer and more efficient work situation. Standard ethnographic methods were used to support the analysis of the current work system and work situations, coupled with cognitive task analysis methods and documents review. Usability inspection (heuristic evaluation) and both in-lab (simulated tasks) and on-site (real tasks) usability tests were performed for the evaluation of the CPOE candidate. Adapted software engineering models were used in combination with usual textual descriptions, tasks models and mock-ups to support the recommendations for work and product re-design. The analysis of the work situations identified different work organisations and procedures across the hospital's departments. The most important differences concerned the doctor-nurse communications and cooperation modes and the procedures for preparing and administering the medications. The assessment of the medication CPOE functions uncovered a number of usability problems including severe ones leading to impossible to detect or to catch errors. Models of the actual and possible distribution of tasks and roles were used to support decision making in the work design process. The results of the usability assessment were translated into requirements to support the necessary re-engineering of the IT application. The HFE approach to medication CPOE efficiently identifies and distinguishes currently unsafe or uncomfortable work situations that could obviously benefit from an IT solution from other work situations incorporating efficient work

  16. Measurement of student attitudes in first year engineering - A mixed methods approach

    Science.gov (United States)

    Malik, Qaiser Hameed

    This research study focused on freshman attitudes towards engineering in a newly implemented cornerstone sequence that emphasized holistic design experiences. The students' initial attitudes and changes in these attitudes were examined with the explanatory mixed methods approach that allows a sequential examination of the target population with two methods, using two sets of data, to investigate the treatment effects. In the quantitative phase, the study compared changes in freshman attitude towards engineering, between the new 'design sequence' group (composed of freshmen in the cornerstone sequence) and the prior 'traditional sequence' group (composed of all other freshmen), over the course of one semester. The data were collected in fall 2008 at two time intervals and changes in the two groups' attitudes were examined with repeated measures analysis of covariance models. The analyses reported here include data from 389 students out of the total population of 722 freshmen. The analyses revealed that engineering freshmen joined the program with positive or strongly positive attitudes towards engineering. Those strong attitudes were durable and resistant to change. Students in the design sequence group had higher ACT scores, enjoyed math and science the most, and did not believe engineering to be an exact science. However, no appreciable time-group interaction was observed. To validate the quantitative results, an interview protocol was developed to investigate initial freshman attitudes and changes, if any, that took place as a result of the new cornerstone sequence. One-on-one interviews with a sample of ten students out of the population of 272 freshmen revealed that freshmen in the cornerstone sequence entered the program full of enthusiasm and idealism, and with strongly positive attitudes towards engineering. The strong motivational factors included parental/teacher influences, childhood motivations, and high school extra-curricular experiences. The

  17. A Science, Engineering and Technology (SET) Approach Improves Science Process Skills in 4-H Animal Science Participants

    Science.gov (United States)

    Clarke, Katie C.

    2010-01-01

    A new Science, Engineering and Technology (SET) approach was designed for youth who participated in the Minnesota State Fair Livestock interview process. The project and evaluation were designed to determine if the new SET approach increased content knowledge and science process skills in participants. Results revealed that youth participants not…

  18. Development of a Study Module on and Pedagogical Approaches to Industrial Environmental Engineering and Sustainability in Mozambique

    Science.gov (United States)

    Husgafvel, Roope; Martikka, Mikko; Egas, Andrade; Ribiero, Natasha; Dahl, Olli

    2017-01-01

    Addressing the sustainability challenges in the forest sector in Mozambique requires capacity building for higher education and training of new skilled expert and future decision-makers. Our approach was to develop a study module on and pedagogical approaches to industrial environmental engineering and sustainability. The idea was to develop a…

  19. Integrating Human Factors Engineering and Information Processing Approaches to Facilitate Evaluations in Criminal Justice Technology Research.

    Science.gov (United States)

    Salvemini, Anthony V; Piza, Eric L; Carter, Jeremy G; Grommon, Eric L; Merritt, Nancy

    2015-06-01

    Evaluations are routinely conducted by government agencies and research organizations to assess the effectiveness of technology in criminal justice. Interdisciplinary research methods are salient to this effort. Technology evaluations are faced with a number of challenges including (1) the need to facilitate effective communication between social science researchers, technology specialists, and practitioners, (2) the need to better understand procedural and contextual aspects of a given technology, and (3) the need to generate findings that can be readily used for decision making and policy recommendations. Process and outcome evaluations of technology can be enhanced by integrating concepts from human factors engineering and information processing. This systemic approach, which focuses on the interaction between humans, technology, and information, enables researchers to better assess how a given technology is used in practice. Examples are drawn from complex technologies currently deployed within the criminal justice system where traditional evaluations have primarily focused on outcome metrics. Although this evidence-based approach has significant value, it is vulnerable to fully account for human and structural complexities that compose technology operations. Guiding principles for technology evaluations are described for identifying and defining key study metrics, facilitating communication within an interdisciplinary research team, and for understanding the interaction between users, technology, and information. The approach posited here can also enable researchers to better assess factors that may facilitate or degrade the operational impact of the technology and answer fundamental questions concerning whether the technology works as intended, at what level, and cost. © The Author(s) 2015.

  20. A biomedical engineering approach to mitigate the errors of prostate biopsy.

    Science.gov (United States)

    Ahmed, Hashim Uddin; Emberton, Mark; Kepner, Gordon; Kepner, Jeremy

    2012-02-07

    The current protocol for detecting and ruling out prostate cancer involves serum PSA testing followed by sampling of the prostate using a transrectal ultrasonography (TRUS)-guided biopsy. Many specialists have discussed how PSA screening has contributed to underdetection of clinically significant prostate cancer, overdiagnosis of clinically insignificant disease and poor risk stratification; however, little consideration has been given to the role of TRUS-guided biopsy in these errors. The performance of TRUS-guided biopsy is constrained by the biomechanical attributes of the sampling strategy, resulting in suboptimal detection efficiency of each core. By using a biomedical engineering approach, a uniform grid sampling strategy could be used to improve the detection efficiency of prostate biopsy. Moreover, the calibration of the sampling can be adjusted by altering the distance between needle deployments. Our model shows that for any given number of needle trajectories, a uniform grid approach will be superior to a divergent, nonuniform strategy for the detection of clinically important disease. This is an important message that should result in a move away from divergent sampling to a uniform grid approach for prostate biopsy.

  1. Comparison of scientific and engineering approaches to the treatment of mixed wastes

    International Nuclear Information System (INIS)

    Gilbert, K.V.; Bowers, J.S.

    1993-12-01

    This paper discusses two approaches to the treatment of mixed waste. (Mixed waste, defined as radioactive waste that is co-contaminated with hazardous waste as defined in the Resource Conservation and Conservation Act, is presently stored throughout the United States awaiting the establishment of treatment capability.)The first approach employs conventional engineering that focuses on low risk technology which has been proven in other industries in similar applications and is adaptable for waste treatment use. The term ''low risk'' means that implementation success is relatively certain, and the major uncertainty is the degree of success. Technologies under consideration include centrifugation, evaporation, microfiltration and stabilization. Process offgases are treated with traditional scrubbers and carbon absorption units.For the scientific approach, Lawrence Livermore National Laboratory is in the conceptual design phase of a project to demonstrate incinerator alternatives to destroy organic contaminants in radioactive waste streams without the use of incineration. This Mixed Waste Management Facility will use approximately 15000 square feet of an existing facility to demonstrate an integrated waste management system. Robotic and telerobotic systems will be employed for waste segregation, characterization and feed preparation. Waste feeds will be treated using molten salt oxidation, mediated electrochemical oxidation and wet oxidation. Residues, which can be managed as radioactive-only waste, will be immobilized in an organic matrix prior to shipment to an authorized disposal site

  2. Engineering Leadership Education--The Search for Definition and a Curricular Approach

    Science.gov (United States)

    Schuhmann, Richard J.

    2010-01-01

    While industry and academia agree that leadership skills are critical for engineering graduates, there exists no consensus regarding the definition of "engineering leadership". The engineering leadership development program at Penn State University has a decade-long experience in teaching leadership to engineering undergraduates. In…

  3. Control of bovine spongiform encephalopathy by genetic engineering: possible approaches and regulatory considerations

    International Nuclear Information System (INIS)

    Gavora, J.S.; Kochhar, H.P.S.; Gifford, G.A.

    2005-01-01

    Transmissible spongiform encephalopathies (TSE) include bovine spongiform encephalopathy (BSE), scrapie in sheep and Creutzfeldt-Jakob disease (CJD) in humans. A new CJD variant (nvCJD) is believed to be related to consumption of meat from BSE cattle. In TSE individuals, prion proteins (PrP) with approximately 250 amino acids convert to the pathogenic prion PrP Sc , leading to a dysfunction of the central neural system. Research elsewhere with mice has indicated a possible genetic engineering approach to the introduction of BSE resistance: individuals with amino acid substitutions at positions 167 or 218, inoculated with a pathogenic prion protein, did not support PrP Sc replication. This raises the possibility of producing prion-resistant cattle with a single PrP amino acid substitution. Since prion-resistant animals might still harbour acquired prion infectivity, regulatory assessment of the engineered animals would need to ascertain that such possible 'carriers' do not result in a threat to animal and human health. (author)

  4. Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy

    Directory of Open Access Journals (Sweden)

    Ting Gong

    2016-01-01

    Full Text Available Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration.

  5. An Approach to Integrating Health Disparities within Undergraduate Biomedical Engineering Education.

    Science.gov (United States)

    Vazquez, Maribel; Marte, Otto; Barba, Joseph; Hubbard, Karen

    2017-11-01

    Health disparities are preventable differences in the incidence, prevalence and burden of disease among communities targeted by gender, geographic location, ethnicity and/or socio-economic status. While biomedical research has identified partial origin(s) of divergent burden and impact of disease, the innovation needed to eradicate health disparities in the United States requires unique engagement from biomedical engineers. Increasing awareness of the prevalence and consequences of health disparities is particularly attractive to today's undergraduates, who have undauntedly challenged paradigms believed to foster inequality. Here, the Department of Biomedical Engineering at The City College of New York (CCNY) has leveraged its historical mission of access-and-excellence to integrate the study of health disparities into undergraduate BME curricula. This article describes our novel approach in a multiyear study that: (i) Integrated health disparities modules at all levels of the required undergraduate BME curriculum; (ii) Developed opportunities to include impacts of health disparities into undergraduate BME research projects and mentored High School summer STEM training; and (iii) Established health disparities-based challenges as BME capstone design and/or independent entrepreneurship projects. Results illustrate the rising awareness of health disparities among the youngest BMEs-to-be, as well as abundant undergraduate desire to integrate health disparities within BME education and training.

  6. Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy

    Science.gov (United States)

    Gong, Ting; Heng, Boon Chin; Lo, Edward Chin Man; Zhang, Chengfei

    2016-01-01

    Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration. PMID:27069484

  7. A MultiAir®/MultiFuel Approach to Enhancing Engine System Efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Reese, Ronald [Chrysler Group LLC., Auburn Hills, MI (United States)

    2015-05-20

    FCA US LLC (formally known as Chrysler Group LLC, and hereinafter “Chrysler”) was awarded an American Recovery and Reinvestment Act (ARRA) funded project by the Department of Energy (DOE) titled “A MultiAir®/MultiFuel Approach to Enhancing Engine System Efficiency” (hereinafter “project”). This award was issued after Chrysler submitted a proposal for Funding Opportunity Announcement DE-FOA- 0000079, “Systems Level Technology Development, Integration, and Demonstration for Efficient Class 8 Trucks (SuperTruck) and Advanced Technology Powertrains for Light-Duty Vehicles (ATP-LD).” Chrysler started work on this project on June 01, 2010 and completed testing activities on August 30, 2014. Overall objectives of this project were; Demonstrate a 25% improvement in combined Federal Test Procedure (FTP) City and Highway fuel economy over a 2009 Chrysler minivan; Accelerate the development of highly efficient engine and powertrain systems for light-duty vehicles, while meeting future emissions standards; and Create and retain jobs in accordance with the American Recovery and Reinvestment Act of 2009

  8. Application of heuristic and machine-learning approach to engine model calibration

    Science.gov (United States)

    Cheng, Jie; Ryu, Kwang R.; Newman, C. E.; Davis, George C.

    1993-03-01

    Automation of engine model calibration procedures is a very challenging task because (1) the calibration process searches for a goal state in a huge, continuous state space, (2) calibration is often a lengthy and frustrating task because of complicated mutual interference among the target parameters, and (3) the calibration problem is heuristic by nature, and often heuristic knowledge for constraining a search cannot be easily acquired from domain experts. A combined heuristic and machine learning approach has, therefore, been adopted to improve the efficiency of model calibration. We developed an intelligent calibration program called ICALIB. It has been used on a daily basis for engine model applications, and has reduced the time required for model calibrations from many hours to a few minutes on average. In this paper, we describe the heuristic control strategies employed in ICALIB such as a hill-climbing search based on a state distance estimation function, incremental problem solution refinement by using a dynamic tolerance window, and calibration target parameter ordering for guiding the search. In addition, we present the application of a machine learning program called GID3* for automatic acquisition of heuristic rules for ordering target parameters.

  9. Fuzzy multiple-criteria decision-making approach for industrial green engineering.

    Science.gov (United States)

    Chiou, Hua-kai; Tzeng, Gwo-hshiung

    2002-12-01

    This paper describes a fuzzy hierarchical analytic approach to determine the weighting of subjective judgments. In addition, it presents a nonadditive fuzzy integral technique to evaluate a green engineering industry case as a fuzzy multicriteria decision-making (FMCDM) problem. When the investment strategies are evaluated from various aspects, such as economic effectiveness, technical feasibility, and environmental regulation, it can be regarded as an FMCDM problem. Since stakeholders cannot clearly estimate each considered criterion in terms of numerical values for the anticipated alternatives/strategies, fuzziness is considered to be applicable. Consequently, this paper uses triangular fuzzy numbers to establish weights and anticipated achievement values. By ranking fuzzy weights and fuzzy synthetic utility values, we can determine the relative importance of criteria and decide the best strategies. This paper applies what is called a lambda fuzzy measure and nonadditive fuzzy integral technique to evaluate the synthetic performance of green engineering strategies for aquatic products processors in Taiwan. In addition, we demonstrate that the nonadditive fuzzy integral is an effective evaluation and appears to be appropriate, especially when the criteria are not independent.

  10. MINA-2008: an approach renewed to the Masters of Nuclear Engineering and its Applications in Spain

    International Nuclear Information System (INIS)

    Herranz, L. E.; Garcia-Cuesta, J. C.; Falcon, S.; Marco, M.; Couhoud, M.

    2008-01-01

    Inspired by the so-called nuclear renaissance, the challenge of preserving nuclear knowledge and expertise and on the basis of the European Education Area, the Master's degree in Nuclear Engineering and Applications (MINA) has been set up by CIEMAT, in close collaboration with Spanish Universities and the national nuclear industries, with a drastically renewed approach. The MINA, born as a professionalizing masters intends to build a bridge between University education and technical know-how demanded by todays nuclear industry and organizations. In short, an enabling training that will provide participants with the actual skills that nuclear sector needs. The five major MINA keystone become are professional orientation, full scope, integrating policy, excellence in mastering and plural academic acceptance. These principles as well as other major MINA features are described in detail in this paper. (Author)

  11. A Control Engineering Approach for Designing an Optimized Treatment Plan for Fibromyalgia.

    Science.gov (United States)

    Deshpande, Sunil; Nandola, Naresh N; Rivera, Daniel E; Younger, Jarred

    2011-06-29

    Control engineering offers a systematic and efficient means for optimizing the effectiveness of behavioral interventions. In this paper, we present an approach to develop dynamical models and subsequently, hybrid model predictive control schemes for assigning optimal dosages of naltrexone as treatment for a chronic pain condition known as fibromyalgia. We apply system identification techniques to develop models from daily diary reports completed by participants of a naltrexone intervention trial. The dynamic model serves as the basis for applying model predictive control as a decision algorithm for automated dosage selection of naltrexone in the face of the external disturbances. The categorical/discrete nature of the dosage assignment creates a need for hybrid model predictive control (HMPC) schemes. Simulation results that include conditions of significant plant-model mismatch demonstrate the performance and applicability of hybrid predictive control for optimized adaptive interventions for fibromyalgia treatment involving naltrexone.

  12. Use of Time- and Frequency-Domain Approaches for Damage Detection in Civil Engineering Structures

    Directory of Open Access Journals (Sweden)

    V. H. Nguyen

    2014-01-01

    Full Text Available The aim of this paper is to apply both time- and frequency-domain-based approaches on real-life civil engineering structures and to assess their capability for damage detection. The methodology is based on Principal Component Analysis of the Hankel matrix built from output-only measurements and of Frequency Response Functions. Damage detection is performed using the concept of subspace angles between a current (possibly damaged state and a reference (undamaged state. The first structure is the Champangshiehl Bridge located in Luxembourg. Several damage levels were intentionally created by cutting a growing number of prestressed tendons and vibration data were acquired by the University of Luxembourg for each damaged state. The second example consists in reinforced and prestressed concrete panels. Successive damages were introduced in the panels by loading heavy weights and by cutting steel wires. The illustrations show different consequences in damage identification by the considered techniques.

  13. An Interdisciplinary Approach Between Medical Informatics and Social Sciences to Transdisciplinary Requirements Engineering for an Integrated Care Setting.

    Science.gov (United States)

    Vielhauer, Jan; Böckmann, Britta

    2017-01-01

    Requirements engineering of software products for elderly people faces some special challenges to ensure a maximum of user acceptance. Within the scope of a research project, a web-based platform and a mobile app are approached to enable people to live in their own home as long as possible. This paper is about a developed method of interdisciplinary requirements engineering by a team of social scientists in cooperation with computer scientists.

  14. Application of a sensemaking approach to ethics training in the physical sciences and engineering.

    Science.gov (United States)

    Kligyte, Vykinta; Marcy, Richard T; Waples, Ethan P; Sevier, Sydney T; Godfrey, Elaine S; Mumford, Michael D; Hougen, Dean F

    2008-06-01

    Integrity is a critical determinant of the effectiveness of research organizations in terms of producing high quality research and educating the new generation of scientists. A number of responsible conduct of research (RCR) training programs have been developed to address this growing organizational concern. However, in spite of a significant body of research in ethics training, it is still unknown which approach has the highest potential to enhance researchers' integrity. One of the approaches showing some promise in improving researchers' integrity has focused on the development of ethical decision-making skills. The current effort proposes a novel curriculum that focuses on broad metacognitive reasoning strategies researchers use when making sense of day-to-day social and professional practices that have ethical implications for the physical sciences and engineering. This sensemaking training has been implemented in a professional sample of scientists conducting research in electrical engineering, atmospheric and computer sciences at a large multi-cultural, multi-disciplinary, and multi-university research center. A pre-post design was used to assess training effectiveness using scenario-based ethical decision-making measures. The training resulted in enhanced ethical decision-making of researchers in relation to four ethical conduct areas, namely data management, study conduct, professional practices, and business practices. In addition, sensemaking training led to researchers' preference for decisions involving the application of the broad metacognitive reasoning strategies. Individual trainee and training characteristics were used to explain the study findings. Broad implications of the findings for ethics training development, implementation, and evaluation in the sciences are discussed.

  15. Colloidal gas aphron foams: A novel approach to a hydrogel based tissue engineered myocardial patch

    Science.gov (United States)

    Johnson, Elizabeth Edna

    Cardiovascular disease currently affects an estimated 58 million Americans and is the leading cause of death in the US. Over 2.3 million Americans are currently living with heart failure a leading cause of which is acute myocardial infarction, during which a part of the heart muscle is damaged beyond repair. There is a great need to develop treatments for damaged heart tissue. One potential therapy involves replacement of nonfunctioning scar tissue with a patch of healthy, functioning tissue. A tissue engineered cardiac patch would be ideal for such an application. Tissue engineering techniques require the use of porous scaffolds, which serve as a 3-D template for initial cell attachment and grow-th leading to tissue formation. The scaffold must also have mechanical properties closely matching those of the tissues at the site of implantation. Our research presents a new approach to meet these design requirements. A unique interaction between poly(vinyl alcohol) and amino acids has been discovered by our lab, resulting in the production of novel gels. These unique synthetic hydrogels along with one natural hydrogel, alginate (derived from brown seaweed), have been coupled with a new approach to tissue scaffold fabrication using solid colloidal gas aphrons (CGAs). CGAs are colloidal foams containing uniform bubbles with diameters on the order of micrometers. Upon solidification the GCAs form a porous, 3-D network suitable for a tissue scaffold. The project encompasses four specific aims: (I) characterize hydrogel formation mechanism, (II) use colloidal gas aphrons to produce hydrogel scaffolds, (III) chemically and physically characterize scaffold materials and (IV) optimize and evaluate scaffold biocompatibility.

  16. NASA's Space Launch System: Systems Engineering Approach for Affordability and Mission Success

    Science.gov (United States)

    Hutt, John J.; Whitehead, Josh; Hanson, John

    2017-01-01

    NASA is working toward the first launch of a new, unmatched capability for deep space exploration, with launch readiness planned for 2018. The initial Block 1 configuration of the Space Launch System will more than double the mass and volume to Low Earth Orbit (LEO) of any launch vehicle currently in operation - with a path to evolve to the greatest capability ever developed. The program formally began in 2011. The vehicle successfully passed Preliminary Design Review (PDR) in 2013, Key Decision Point C (KDPC) in 2014 and Critical Design Review (CDR) in October 2015 - nearly 40 years since the last CDR of a NASA human-rated rocket. Every major SLS element has completed components of test and flight hardware. Flight software has completed several development cycles. RS-25 hotfire testing at NASA Stennis Space Center (SSC) has successfully demonstrated the space shuttle-heritage engine can perform to SLS requirements and environments. The five-segment solid rocket booster design has successfully completed two full-size motor firing tests in Utah. Stage and component test facilities at Stennis and NASA Marshall Space Flight Center are nearing completion. Launch and test facilities, as well as transportation and other ground support equipment are largely complete at NASA's Kennedy, Stennis and Marshall field centers. Work is also underway on the more powerful Block 1 B variant with successful completion of the Exploration Upper Stage (EUS) PDR in January 2017. NASA's approach is to develop this heavy lift launch vehicle with limited resources by building on existing subsystem designs and existing hardware where available. The systems engineering and integration (SE&I) of existing and new designs introduces unique challenges and opportunities. The SLS approach was designed with three objectives in mind: 1) Design the vehicle around the capability of existing systems; 2) Reduce work hours for nonhardware/ software activities; 3) Increase the probability of mission

  17. Approach and strategy for performing ecological risk assessments for the US Department of Energy`s Oak Ridge Reservation: 1995 revision

    Energy Technology Data Exchange (ETDEWEB)

    Suter, G.W. II; Sample, B.E.; Jones, D.S.; Ashwood, T.L.; Loar, J.M.

    1995-09-01

    The purpose of this document is to provide guidance for planning and performing ecological risk assessments (ERAs) on the Oak Ridge Reservation (ORR). It is the third such document prepared for this purpose. The first ecorisk strategy document described the ERA process and presented a tiered approach to ERAs appropriate to complex sites. The first revision was necessitated by the considerable progress that has been made by the parties to the Federal Facilities Agreement (FFA) for the ORR in resolving specific issues relating to ERA as a result of a series of data quality objectives (DQOs) meetings. The tiered approach to ERAs as recommended in the first document was implemented, generic conceptual models were developed, and a general approach for developing ecological assessment endpoints and measurement endpoints was agreed upon. This revision is necessitated by comments from the US Environmental Protection Agency`s Region IV and the Tennessee Department of Environment and Conservation (TDEC) which clarified and modified the positions taken during the DQO process. In particular, support for the collection of data that would support ERAs for all OUs on the ORR have been withdrawn. Therefore, the work plan developed to fill the reservation-wide data needs identified in the DQO process has also been withdrawn, and portions that are still relevant have been incorporated into this document. The reader should be aware that this guidance is complex and lengthy because it attempts to cover all the reasonable contingencies that were considered to be potentially important to the FFA parties.

  18. Increasing the number of African American PhDs in the sciences and engineering: a strengths-based approach.

    Science.gov (United States)

    Maton, Kenneth I; Hrabowski, Freeman A

    2004-09-01

    Fifty years after Brown v. Board of Education, the percentage of African American students who receive PhDs in natural science, technology, engineering, or mathematics (STEM) fields remains disappointingly low. A multifaceted, strengths-based approach to intervention and research that holds great promise for increasing the number of African American students who achieve at the highest levels academically is described. This work began in 1988 with the development of the Meyerhoff Scholars Program for undergraduate minority STEM majors at the University of Maryland, Baltimore County (UMBC). If current PhD receipt rates of program graduates continue, UMBC will in all likelihood become the leading predominantly White baccalaureate-origin university for Black STEM PhDs in the nation. The program is described and outcome and process findings from its ongoing evaluation are highlighted. The parenting practices that helped these youths to overcome the odds and achieve at the highest levels prior to coming to college are also examined. ((c) 2004 APA, all rights reserved)

  19. Retina tissue engineering by conjunctiva mesenchymal stem cells encapsulated in fibrin gel: Hypotheses on novel approach to retinal diseases treatment.

    Science.gov (United States)

    Soleimannejad, Mostafa; Ebrahimi-Barough, Somayeh; Nadri, Samad; Riazi-Esfahani, Mohammad; Soleimani, Masoud; Tavangar, Seyed Mohammad; Ai, Jafar

    2017-04-01

    Retinitis pigmentosa (RP) and age related macular degeneration (AMD) are two retinal diseases that progress by photoreceptor cells death. In retinal transplantation studies, stem and progenitor cells inject into the sub retinal space or vitreous and then these cells can be migrate to the site of retinal degeneration and locate in the host retina and restitute vision. Our hypothesis suggests that using human conjunctiva stem cells (as the source for increasing the number of human stem cells progenitor cells in retina dysfunction diseases) with fibrin gel and also assessing its relating in vitro (cellular and molecular processes) and in vivo (vision tests and pathology) could be a promising strategy for treatment of AMD and RP disorders. In this idea, we describe a novel approach for retina tissue engineering with differentiation of conjunctiva mesenchymal stem cells (CJMSCs) into photoreceptor-like cells in fibrin gel with induction medium contain taurine. For assessment of differentiation, immunocytochemistry and real time PCR are used for the expression of Rhodopsin, RPE65, Nestin as differentiated photoreceptor cell markers in 2D and 3D culture. The results show that fibrin gel will offer a proper 3D scaffold for CJMSCs derived photoreceptor cell-like cells. Application of immune-privileged, readily available sources of adult stem cells like human conjunctiva stem cells with fibrin gel would be a promising strategy to increase the number of photoreceptor progenitor cells and promote involuntary angiogenesis needed in retina layer repair and regeneration. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Engineering simulation evaluation of the two-segment noise abatement approach in the Douglas DC-8-61

    Science.gov (United States)

    Nylen, W. E.

    1974-01-01

    The development and operational evaluation are discussed of a noise abatement two-segment approach which is safe and operationally acceptable for routine use in air carrier service. An engineering simulation evaluation was conducted; it was found that the entry speed and initial configuration are more important in the DC-8-61 than in the 727 because of the DC-8's aerodynamic cleanliness and drag programming constraints. It was also found that the altitude required for the DC-8 upper and lower transitions is less than the 727 transitions principally due to the pitching moment from the underslung DC-8 engines as compared to the 727 engines which produce no pitching moment with a change in thrust. The 727 approach was a reduced flaps (30 degrees) procedure with a 10-knot airspeed bleed in the lower transition; the DC-8 approach is a full flaps (50 degrees) procedure with constant airspeed established as soon as possible after upper segment transition.

  1. A chemical genetic approach to engineer phototropin kinases for substrate labeling.

    Science.gov (United States)

    Schnabel, Jonathan; Hombach, Peter; Waksman, Thomas; Giuriani, Giovanni; Petersen, Jan; Christie, John M

    2018-04-13

    Protein kinases (PKs) control many aspects of plant physiology by regulating signaling networks through protein phosphorylation. Phototropins (phots) are plasma membrane-associated serine/threonine PKs that control a range of physiological processes that collectively serve to optimize photosynthetic efficiency in plants. These include phototropism, leaf positioning and flattening, chloroplast movement, and stomatal opening. Despite their identification over two decades ago, only a handful of substrates have been identified for these PKs. Progress in this area has been hampered by the lack of a convenient means to confirm the identity of potential substrate candidates. Here we demonstrate that the kinase domain of Arabidopsis phot1 and phot2 can be successfully engineered to accommodate non-natural ATP analogues by substituting the bulky gatekeeper residue threonine for glycine. This approach circumvents the need for radioactivity to track phot kinase activity and follow light-induced receptor autophosphorylation in vitro by incorporating thiophosphate from N 6 -benzyl-ATPγS. Consequently, thiophosphorylation of phot substrate candidates can be readily monitored when added or co-expressed with phots in vitro Furthermore, gatekeeper-modified phot1 retained its functionality and its ability to accommodate N 6 -benzyl-ATPγS as a phosphodonor when expressed in Arabidopsis We therefore anticipate that this chemical genetic approach will provide new opportunities for labeling and identifying substrates for phots and other related AGC kinases under in vitro and near-native in vivo conditions. © 2018 Schnabel et al.

  2. An information-based rough set approach to critical engineering factor identification

    Directory of Open Access Journals (Sweden)

    Jing Ji

    2008-09-01

    Full Text Available In order to analyze the main critical engineering factors, an information-based rough set approach that considers conditional information entropy as a measurement of information has been developed. An algorithm for continuous attribute discretization based on conditional information entropy and an algorithm for rule extraction considering the supports of rules are proposed. The initial decision system is established by collecting enough monitoring data. Then, the continuous attributes are discretized, and the condition attributes are reduced. Finally, the rules that indicate the action law of the main factors are extracted and the results are explained. By applying this approach to a crack in an arch gravity dam, it can be concluded that the water level and the temperature are the main factors affecting the crack opening, and there is a negative correlation between the crack opening and the temperature. This conclusion corresponds with the observation that cracks in most concrete dams are influenced mainly by water level and temperature, and the influence of temperature is more evident.

  3. From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.

    Science.gov (United States)

    MacEwan, Sarah R; Chilkoti, Ashutosh

    2017-06-06

    The molecular complexity and heterogeneity of cancer has led to a persistent, and as yet unsolved, challenge to develop cures for this disease. The pharmaceutical industry focuses the bulk of its efforts on the development of new drugs, but an alternative approach is to improve the delivery of existing drugs with drug carriers that can manipulate when, where, and how a drug exerts its therapeutic effect. For the treatment of solid tumors, systemically delivered drug carriers face significant challenges that are imposed by the pathophysiological barriers that lie between their site of administration and their site of therapeutic action in the tumor. Furthermore, drug carriers face additional challenges in their translation from preclinical validation to clinical approval and adoption. Addressing this diverse network of challenges requires a systems engineering approach for the rational design of optimized carriers that have a realistic prospect for translation from the laboratory to the patient. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Prediction analysis of effluent removal in a septic sludge treatment plant: a biomimetics engineering approach.

    Science.gov (United States)

    Chun, Ting Sie; Malek, M A; Ismail, Amelia Ritahani

    2014-09-20

    Effluent discharge from septic tanks is affecting the environment in developing countries. The most challenging issue facing these countries is the cost of inadequate sanitation, which includes significant economic, social, and environmental burdens. Although most sanitation facilities are evaluated based on their immediate costs and benefits, their long-term performance should also be investigated. In this study, effluent quality-namely, the biological oxygen demand (BOD), chemical oxygen demand (COD), and total suspended solid (TSS)-was assessed using a biomimetics engineering approach. A novel immune network algorithm (INA) approach was applied to a septic sludge treatment plant (SSTP) for effluent-removal predictive modelling. The Matang SSTP in the city of Kuching, Sarawak, on the island of Borneo, was selected as a case study. Monthly effluent discharges from 2007 to 2011 were used for training, validating, and testing purposes using MATLAB 7.10. The results showed that the BOD effluent-discharge prediction was less than 50% of the specified standard after the 97(th) month of operation. The COD and TSS effluent removals were simulated at the 85(th) and the 121(st) months, respectively. The study proved that the proposed INA-based SSTP model could be used to achieve an effective SSTP assessment and management technique.

  5. Approach and strategy for performing ecological risk assessments for the U.S. Department of Energy`s Oak Ridge Reservation: 1994 revision

    Energy Technology Data Exchange (ETDEWEB)

    Suter, G.W. II; Sample, B.E.; Jones, D.S.; Ashwood, T.L.

    1994-08-01

    This report provides guidance for planning and performing ecological risk assessments on the Oak Ridge Reservation (ORR). The tiered approach to ecological risk assessment has been implemented, generic conceptual models have been developed, and a general approach for developing ecological assessment endpoints and measurement endpoints has been agreed upon. The document also includes changes in terminology to agree with the terminology in the US Environmental Protection Agency`s (EPA`s) framework for ecological risk assessment. Although ecological risks are equal in regulatory importance to human health risks, formal procedures for ecological risk assessment are poorly developed. This report will provide specific guidance and promote the use of consistent approaches for ecological risk assessments at individual sites on the ORR. The strategy discussed in this report is consistent with the overall strategy for site management and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) compliance and with relevant EPA guidance. The general approach and strategy presented herein was developed for the ORR, but it should be applicable to other complex CERCLA sites that possess significant ecological resources.

  6. Approach and strategy for performing ecological risk assessments for the U.S. Department of Energy's Oak Ridge Reservation: 1994 revision

    International Nuclear Information System (INIS)

    Suter, G.W. II; Sample, B.E.; Jones, D.S.; Ashwood, T.L.

    1994-08-01

    This report provides guidance for planning and performing ecological risk assessments on the Oak Ridge Reservation (ORR). The tiered approach to ecological risk assessment has been implemented, generic conceptual models have been developed, and a general approach for developing ecological assessment endpoints and measurement endpoints has been agreed upon. The document also includes changes in terminology to agree with the terminology in the US Environmental Protection Agency's (EPA's) framework for ecological risk assessment. Although ecological risks are equal in regulatory importance to human health risks, formal procedures for ecological risk assessment are poorly developed. This report will provide specific guidance and promote the use of consistent approaches for ecological risk assessments at individual sites on the ORR. The strategy discussed in this report is consistent with the overall strategy for site management and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) compliance and with relevant EPA guidance. The general approach and strategy presented herein was developed for the ORR, but it should be applicable to other complex CERCLA sites that possess significant ecological resources

  7. Two Different Approaches to Teaching Final-Year Projects for Mechanical Engineers and Biotechnologists at Ngee Ann Polytechnic--Case Studies Approach.

    Science.gov (United States)

    Walsh, Kath; Rebaczonok-Padulo, Michael

    1993-01-01

    Ngee Ann Polytechnic, a leading postsecondary technical institution in Singapore, offers English for academic and occupational purposes to prepare students for writing their final year projects. This article discusses the approaches used in Mechanical Engineering and Biotechnology projects. A sample exercise is appended. (Contains two references.)…

  8. Alternative approaches to reliability modeling of a multiple engineered barrier system

    International Nuclear Information System (INIS)

    Ananda, M.M.A.; Singh, A.K.

    1994-01-01

    The lifetime of the engineered barrier system used for containment of high-level radioactive waste will significantly impact the total performance of a geological repository facility. Currently two types of designs are under consideration for an engineered barrier system, single engineered barrier system and multiple engineered barrier system. Multiple engineered barrier system consists of several metal barriers and the waste form (cladding). Some recent work show that a significant improvement of performance can be achieved by utilizing multiple engineered barrier systems. Considering sequential failures for each barrier, we model the reliability of the multiple engineered barrier system. Weibull and exponential lifetime distributions are used through out the analysis. Furthermore, the number of failed engineered barrier systems in a repository at a given time is modeled using a poisson approximation

  9. Engineering Biology by Controlling Tissue Folding.

    Science.gov (United States)

    Hookway, Tracy A

    2018-04-01

    Achieving complex self-organization in vitro has remained a fundamental challenge in tissue engineering. A recent study in Developmental Cell by Hughes and colleagues uses computational and experimental approaches to understand and control the morphogenic process of tissue folding. These approaches provide an engineering framework to reproducibly control tissue shape. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks.

    Science.gov (United States)

    Ferrazzi, Fulvia; Sebastiani, Paola; Ramoni, Marco F; Bellazzi, Riccardo

    2007-05-24

    Reverse engineering cellular networks is currently one of the most challenging problems in systems biology. Dynamic Bayesian networks (DBNs) seem to be particularly suitable for inferring relationships between cellular variables from the analysis of time series measurements of mRNA or protein concentrations. As evaluating inference results on a real dataset is controversial, the use of simulated data has been proposed. However, DBN approaches that use continuous variables, thus avoiding the information loss associated with discretization, have not yet been extensively assessed, and most of the proposed approaches have dealt with linear Gaussian models. We propose a generalization of dynamic Gaussian networks to accommodate nonlinear dependencies between variables. As a benchmark dataset to test the new approach, we used data from a mathematical model of cell cycle control in budding yeast that realistically reproduces the complexity of a cellular system. We evaluated the ability of the networks to describe the dynamics of cellular systems and their precision in reconstructing the true underlying causal relationships between variables. We also tested the robustness of the results by analyzing the effect of noise on the data, and the impact of a different sampling time. The results confirmed that DBNs with Gaussian models can be effectively exploited for a first level analysis of data from complex cellular systems. The inferred models are parsimonious and have a satisfying goodness of fit. Furthermore, the networks not only offer a phenomenological description of the dynamics of cellular systems, but are also able to suggest hypotheses concerning the causal interactions between variables. The proposed nonlinear generalization of Gaussian models yielded models characterized by a slightly lower goodness of fit than the linear model, but a better ability to recover the true underlying connections between variables.

  11. Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks

    Directory of Open Access Journals (Sweden)

    Ramoni Marco F

    2007-05-01

    Full Text Available Abstract Background Reverse engineering cellular networks is currently one of the most challenging problems in systems biology. Dynamic Bayesian networks (DBNs seem to be particularly suitable for inferring relationships between cellular variables from the analysis of time series measurements of mRNA or protein concentrations. As evaluating inference results on a real dataset is controversial, the use of simulated data has been proposed. However, DBN approaches that use continuous variables, thus avoiding the information loss associated with discretization, have not yet been extensively assessed, and most of the proposed approaches have dealt with linear Gaussian models. Results We propose a generalization of dynamic Gaussian networks to accommodate nonlinear dependencies between variables. As a benchmark dataset to test the new approach, we used data from a mathematical model of cell cycle control in budding yeast that realistically reproduces the complexity of a cellular system. We evaluated the ability of the networks to describe the dynamics of cellular systems and their precision in reconstructing the true underlying causal relationships between variables. We also tested the robustness of the results by analyzing the effect of noise on the data, and the impact of a different sampling time. Conclusion The results confirmed that DBNs with Gaussian models can be effectively exploited for a first level analysis of data from complex cellular systems. The inferred models are parsimonious and have a satisfying goodness of fit. Furthermore, the networks not only offer a phenomenological description of the dynamics of cellular systems, but are also able to suggest hypotheses concerning the causal interactions between variables. The proposed nonlinear generalization of Gaussian models yielded models characterized by a slightly lower goodness of fit than the linear model, but a better ability to recover the true underlying connections between

  12. A Hybrid PCA-CART-MARS-Based Prognostic Approach of the Remaining Useful Life for Aircraft Engines

    Directory of Open Access Journals (Sweden)

    Fernando Sánchez Lasheras

    2015-03-01

    Full Text Available Prognostics is an engineering discipline that predicts the future health of a system. In this research work, a data-driven approach for prognostics is proposed. Indeed, the present paper describes a data-driven hybrid model for the successful prediction of the remaining useful life of aircraft engines. The approach combines the multivariate adaptive regression splines (MARS technique with the principal component analysis (PCA, dendrograms and classification and regression trees (CARTs. Elements extracted from sensor signals are used to train this hybrid model, representing different levels of health for aircraft engines. In this way, this hybrid algorithm is used to predict the trends of these elements. Based on this fitting, one can determine the future health state of a system and estimate its remaining useful life (RUL with accuracy. To evaluate the proposed approach, a test was carried out using aircraft engine signals collected from physical sensors (temperature, pressure, speed, fuel flow, etc.. Simulation results show that the PCA-CART-MARS-based approach can forecast faults long before they occur and can predict the RUL. The proposed hybrid model presents as its main advantage the fact that it does not require information about the previous operation states of the input variables of the engine. The performance of this model was compared with those obtained by other benchmark models (multivariate linear regression and artificial neural networks also applied in recent years for the modeling of remaining useful life. Therefore, the PCA-CART-MARS-based approach is very promising in the field of prognostics of the RUL for aircraft engines.

  13. A divide and conquer approach to determine the Pareto frontier for optimization of protein engineering experiments

    Science.gov (United States)

    He, Lu; Friedman, Alan M.; Bailey-Kellogg, Chris

    2016-01-01

    In developing improved protein variants by site-directed mutagenesis or recombination, there are often competing objectives that must be considered in designing an experiment (selecting mutations or breakpoints): stability vs. novelty, affinity vs. specificity, activity vs. immunogenicity, and so forth. Pareto optimal experimental designs make the best trade-offs between competing objectives. Such designs are not “dominated”; i.e., no other design is better than a Pareto optimal design for one objective without being worse for another objective. Our goal is to produce all the Pareto optimal designs (the Pareto frontier), in order to characterize the trade-offs and suggest designs most worth considering, but to avoid explicitly considering the large number of dominated designs. To do so, we develop a divide-and-conquer algorithm, PEPFR (Protein Engineering Pareto FRontier), that hierarchically subdivides the objective space, employing appropriate dynamic programming or integer programming methods to optimize designs in different regions. This divide-and-conquer approach is efficient in that the number of divisions (and thus calls to the optimizer) is directly proportional to the number of Pareto optimal designs. We demonstrate PEPFR with three protein engineering case studies: site-directed recombination for stability and diversity via dynamic programming, site-directed mutagenesis of interacting proteins for affinity and specificity via integer programming, and site-directed mutagenesis of a therapeutic protein for activity and immunogenicity via integer programming. We show that PEPFR is able to effectively produce all the Pareto optimal designs, discovering many more designs than previous methods. The characterization of the Pareto frontier provides additional insights into the local stability of design choices as well as global trends leading to trade-offs between competing criteria. PMID:22180081

  14. The pulse tube engine: A numerical and experimental approach on its design, performance, and operating conditions

    International Nuclear Information System (INIS)

    Moldenhauer, Stefan; Stark, Tilman; Holtmann, Christoph; Thess, André

    2013-01-01

    The pulse tube engine is a simple heat engine based on the pulse tube process. Due to its simplicity it has a high potential to be applicable in waste heat usage and energy harvesting purposes. In this work, mathematical and experimental design tools are developed to study a pressurized laboratory scale pulse tube engine. The mathematical model is based on the transient numerical solution of the governing differential equations for mass, momentum and energy. The Modelica environment of SimulationX is used to solve the equations numerically and the model is employed to design the experimental test engine with helium as working fluid. The transient behavior of the pulse tube engine's underlying thermodynamic properties is studied numerically and experimentally under different design parameters as well as for different heat input temperatures, filling pressures and operating frequencies. The measured engine characteristics are compared with the calculated predictions. Internal and external power losses are quantified. Design studies for a further development of the pulse tube engine are performed experimentally. The developed numerical tool provides a rational framework for up-scaling the current laboratory model to industrial scale. - Highlights: • We developed a mathematical model and an experimental test engine to study the pulse tube engine. • The experimental test engine is able to operate with pressurized helium of up to 12 bar filling pressure. • We characterized and compared the engine's behavior under different design features and operating conditions. • Design studies for a further development of the pulse tube engine are performed experimentally

  15. Innovative Approaches to Information Literacy Instruction for Engineering Undergraduates at Drexel University

    Science.gov (United States)

    Roberts, Joshua C.; Bhatt, Jay

    2007-01-01

    As information professionals, engineering librarians have the primary responsibilities of providing access to engineering information resources and giving instruction in how to use these resources. In the case of undergraduate engineering students, this extends to building their information literacy skills, an important component in helping them…

  16. A bottom up approach for engineering catchments through sustainable runoff management

    Science.gov (United States)

    Wilkinson, M.; Quinn, P. F.; Jonczyk, J.; Burke, S.

    2010-12-01

    There is no doubt that our catchments are under great stress. There have been many accounts around the world of severe flood events and water quality issues within channels. As a result of these, ecological habitats in rivers are also under pressure. Within the United Kingdom, all these issues have been identified as key target areas for policy. Traditionally this has been managed by a policy driven top down approach which is usually ineffective. A one ‘size fits all’ attitude often does not work. This paper presents a case study in northern England whereby a bottom up approach is applied to multipurpose managing of catchments at the source (in the order of 1-10km2). This includes simultaneous tackling of water quality, flooding and ecological issues by creating sustainable runoff management solutions such as storage ponds, wetlands, beaver dams and willow riparian features. In order to identify the prevailing issues in a specific catchment, full and transparent stakeholder engagement is essential, with everybody who has a vested interest in the catchment being involved from the beginning. These problems can then be dealt with through the use of a novel catchment management toolkit, which is transferable to similar scale catchments. However, evidence collected on the ground also allows for upscaling of the toolkit. The process gathers the scientific evidence about the effectiveness of existing or new measures, which can really change the catchment functions. Still, we need to get better at communicating the science to policy makers and policy therefore must facilitate a bottom up approach to land and water management. We show a test site for this approach in the Belford burn catchment (6km2), northern England. This catchment has problems with flooding and water quality. Increased sediment loads are affecting the nearby estuary which is an important ecological zone and numerous floods have affected the local village. A catchment engineering toolkit has been

  17. Incorporating a Systems Approach into Civil and Environmental Engineering Curricula: Effect on Course Redesign, and Student and Faculty Attitudes

    Science.gov (United States)

    Hayden, Nancy J.; Rizzo, Donna M.; Dewoolkar, Mandar M.; Neumann, Maureen D.; Lathem, Sandra; Sadek, Adel

    2011-01-01

    This paper presents a brief overview of the changes made during our department level reform (DLR) process (Grant Title: "A Systems Approach for Civil and Environmental Engineering Education: Integrating Systems Thinking, Inquiry-Based Learning and Catamount Community Service-Learning Projects") and some of the effects of these changes on…

  18. Integrative Approaches among Science, Technology, Engineering, and Mathematics (STEM) Subjects on Students' Learning: A Meta-Analysis

    Science.gov (United States)

    Becker, Kurt Henry; Park, Kyungsuk

    2011-01-01

    Within the literature there has been a call for the integration of science, technology, engineering, and mathematics (STEM) disciplines. Little research has been conducted to investigate the effects of integrative approaches among STEM subjects. The purpose of this study was to synthesize findings from existing research on the effects of…

  19. Educational Analysis of a First Year Engineering Physics Experiment on Standing Waves: Based on the ACELL Approach

    Science.gov (United States)

    Bhathal, Ragbir; Sharma, Manjula D.; Mendez, Alberto

    2010-01-01

    This paper describes an educational analysis of a first year physics experiment on standing waves for engineering students. The educational analysis is based on the ACELL (Advancing Chemistry by Enhancing Learning in the Laboratory) approach which includes a statement of educational objectives and an analysis of student learning experiences. The…

  20. Introducing a Transdisciplinary Approach in Studies regarding Risk Assessment and Management in Educational Programs for Environmental Engineers and Planners

    Science.gov (United States)

    Menoni, Scira

    2006-01-01

    Purpose: The purpose of this paper is to discuss how long term risk prevention and civil protection may enter in university programs for environmental engineers and urban and regional planners. Design/methodology/approach: First the distinction between long term risk prevention and emergency preparedness is made, showing that while the first has…

  1. A user-centered, iterative engineering approach for advanced biomass cookstove design and development

    Science.gov (United States)

    Shan, Ming; Carter, Ellison; Baumgartner, Jill; Deng, Mengsi; Clark, Sierra; Schauer, James J.; Ezzati, Majid; Li, Jiarong; Fu, Yu; Yang, Xudong

    2017-09-01

    Unclean combustion of solid fuel for cooking and other household energy needs leads to severe household air pollution and adverse health impacts in adults and children. Replacing traditional solid fuel stoves with high efficiency, low-polluting semi-gasifier stoves can potentially contribute to addressing this global problem. The success of semi-gasifier cookstove implementation initiatives depends not only on the technical performance and safety of the stove, but also the compatibility of the stove design with local cooking practices, the needs and preferences of stove users, and community economic structures. Many past stove design initiatives have failed to address one or more of these dimensions during the design process, resulting in failure of stoves to achieve long-term, exclusive use and market penetration. This study presents a user-centered, iterative engineering design approach to developing a semi-gasifier biomass cookstove for rural Chinese homes. Our approach places equal emphasis on stove performance and meeting the preferences of individuals most likely to adopt the clean stove technology. Five stove prototypes were iteratively developed following energy market and policy evaluation, laboratory and field evaluations of stove performance and user experience, and direct interactions with stove users. The most current stove prototype achieved high performance in the field on thermal efficiency (ISO Tier 3) and pollutant emissions (ISO Tier 4), and was received favorably by rural households in the Sichuan province of Southwest China. Among household cooks receiving the final prototype of the intervention stove, 88% reported lighting and using it at least once. At five months post-intervention, the semi-gasifier stoves were used at least once on an average of 68% [95% CI: 43, 93] of days. Our proposed design strategy can be applied to other stove development initiatives in China and other countries.

  2. Genetic engineering represents a safe approach for innovations improving nutritional contents of major food crops

    Directory of Open Access Journals (Sweden)

    Werner Arber

    2017-05-01

    Full Text Available About 70 years ago early microbial genetic research revealed that inherited phenotypic traits become determined by DNA filaments composed of 4 different nucleotides that are linearly arranged. In the meantime we know that genes, the determinants of specific life functions, are genomic segments of an average size of about 1000 nucleotides, i.e. a very small part of a genome. Fundamental insights into the structures and functions of selected genes can be reached by sorting out the relevant short DNA segment, splicing this fragment into a natural gene vector such as a viral genome or a fertility plasmid. This allows the researchers to transfer the genetic hybrid into an appropriate host cell in order to produce many copies that can then serve for functional and structural analysis. This research approach became efficient in the 1970s. On the request of involved researchers, safety guidelines became proposed 1975 at the Asilomar Conference on Recombinant DNA (Berg, Baltimore, Brenner, Roblin, & Singer, 1975, then generally introduced and still largely followed nowadays. Carefully carried out genetic engineering by horizontally transferring a selected and functionally well known DNA segment into the genome of another organism has in many published biosafety investigations never shown any unexpected harmful effect. We will present below selected examples of research contributions enabling innovations for the benefit of human life conditions.

  3. Enhanced Missing Proteins Detection in NCI60 Cell Lines Using an Integrative Search Engine Approach

    Science.gov (United States)

    2017-01-01

    The Human Proteome Project (HPP) aims deciphering the complete map of the human proteome. In the past few years, significant efforts of the HPP teams have been dedicated to the experimental detection of the missing proteins, which lack reliable mass spectrometry evidence of their existence. In this endeavor, an in depth analysis of shotgun experiments might represent a valuable resource to select a biological matrix in design validation experiments. In this work, we used all the proteomic experiments from the NCI60 cell lines and applied an integrative approach based on the results obtained from Comet, Mascot, OMSSA, and X!Tandem. This workflow benefits from the complementarity of these search engines to increase the proteome coverage. Five missing proteins C-HPP guidelines compliant were identified, although further validation is needed. Moreover, 165 missing proteins were detected with only one unique peptide, and their functional analysis supported their participation in cellular pathways as was also proposed in other studies. Finally, we performed a combined analysis of the gene expression levels and the proteomic identifications from the common cell lines between the NCI60 and the CCLE project to suggest alternatives for further validation of missing protein observations. PMID:28960077

  4. Enhanced Missing Proteins Detection in NCI60 Cell Lines Using an Integrative Search Engine Approach.

    Science.gov (United States)

    Guruceaga, Elizabeth; Garin-Muga, Alba; Prieto, Gorka; Bejarano, Bartolomé; Marcilla, Miguel; Marín-Vicente, Consuelo; Perez-Riverol, Yasset; Casal, J Ignacio; Vizcaíno, Juan Antonio; Corrales, Fernando J; Segura, Victor

    2017-12-01

    The Human Proteome Project (HPP) aims deciphering the complete map of the human proteome. In the past few years, significant efforts of the HPP teams have been dedicated to the experimental detection of the missing proteins, which lack reliable mass spectrometry evidence of their existence. In this endeavor, an in depth analysis of shotgun experiments might represent a valuable resource to select a biological matrix in design validation experiments. In this work, we used all the proteomic experiments from the NCI60 cell lines and applied an integrative approach based on the results obtained from Comet, Mascot, OMSSA, and X!Tandem. This workflow benefits from the complementarity of these search engines to increase the proteome coverage. Five missing proteins C-HPP guidelines compliant were identified, although further validation is needed. Moreover, 165 missing proteins were detected with only one unique peptide, and their functional analysis supported their participation in cellular pathways as was also proposed in other studies. Finally, we performed a combined analysis of the gene expression levels and the proteomic identifications from the common cell lines between the NCI60 and the CCLE project to suggest alternatives for further validation of missing protein observations.

  5. A knowledge engineering approach for improving secondary recovery in offshore reservoirs

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Milton P.; Tovar, Felipe T.R.; Guerra, Fabio A. [Parana Institute of Technology (TECPAR), Curitiba, PR (Brazil). Artificial Intelligence Div.; Andrade, Cynthia; Baptista, Walmar [PETROBRAS, Rio de Janeiro, RJ (Brazil). Centro de Pesquisas. Tecnologia de Materiais, Equipamentos e Corrosao

    2004-07-01

    Secondary recovery in offshore petroleum reservoirs by seawater injection is a technique traditionally applied in oil and gas industry. However, the injected water quality must be compatible with the reservoir characteristics in order to prevent corrosion, formation plugging and reservoir souring. So, the seawater must be treated before injection in the reservoirs and on-line monitoring equipment are employed to check the treatments efficacy. Nevertheless, the amount of data to analyze is quite big and involves many different experts, which make their evaluation and the establishment of correlations very difficult. For these cases, where it's crucial to detect the contaminants presence as soon as they occur to indicate corrective procedures, the application of knowledge engineering techniques and the development of expert systems are a good solution proposal. This paper presents the expert system InjeX (heuristic approach), developed for seawater injection treatment plants to maintain the water quality in offshore platforms. The description and the analysis of the problem, a proposed solution and some preliminary results are detailed and discussed along the paper. (author)

  6. Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination.

    Science.gov (United States)

    Wu, Fuqing; Su, Ri-Qi; Lai, Ying-Cheng; Wang, Xiao

    2017-04-11

    The process of cell fate determination has been depicted intuitively as cells travelling and resting on a rugged landscape, which has been probed by various theoretical studies. However, few studies have experimentally demonstrated how underlying gene regulatory networks shape the landscape and hence orchestrate cellular decision-making in the presence of both signal and noise. Here we tested different topologies and verified a synthetic gene circuit with mutual inhibition and auto-activations to be quadrastable, which enables direct study of quadruple cell fate determination on an engineered landscape. We show that cells indeed gravitate towards local minima and signal inductions dictate cell fates through modulating the shape of the multistable landscape. Experiments, guided by model predictions, reveal that sequential inductions generate distinct cell fates by changing landscape in sequence and hence navigating cells to different final states. This work provides a synthetic biology framework to approach cell fate determination and suggests a landscape-based explanation of fixed induction sequences for targeted differentiation.

  7. Modeling of multisensory convergence with a network of spiking neurons: a reverse engineering approach.

    Science.gov (United States)

    Lim, Hun Ki; Keniston, Leslie P; Cios, Krzysztof J

    2011-07-01

    Multisensory processing in the brain underlies a wide variety of perceptual phenomena, but little is known about the underlying mechanisms of how multisensory neurons are formed. This lack of knowledge is due to the difficulty for biological experiments to manipulate and test the parameters of multisensory convergence, the first and definitive step in the multisensory process. Therefore, by using a computational model of multisensory convergence, this study seeks to provide insight into the mechanisms of multisensory convergence. To reverse-engineer multisensory convergence, we used a biologically realistic neuron model and a biology-inspired plasticity rule, but did not make any a priori assumptions about multisensory properties of neurons in the network. The network consisted of two separate projection areas that converged upon neurons in a third area, and stimulation involved activation of one of the projection areas (or the other) or their combination. Experiments consisted of two parts: network training and multisensory simulation. Analyses were performed, first, to find multisensory properties in the simulated networks; second, to reveal properties of the network using graph theoretical approach; and third, to generate hypothesis related to the multisensory convergence. The results showed that the generation of multisensory neurons related to the topological properties of the network, in particular, the strengths of connections after training, was found to play an important role in forming and thus distinguishing multisensory neuron types. © 2011 IEEE

  8. Cross-disciplinary problem-solving workshop: a pedagogical approach to anticipate ergonomist engineering design collaboration.

    Science.gov (United States)

    Brunier, Elisabeth; Le Chapellier, Michel; Dejean, Pierre Henri

    2012-01-01

    The aims of this paper are to present concept and results of an innovative educational model approach based on ergonomics involvement in industrial project. First we present Cross disciplinary Problem solving Workshop by answering three questions:1) What is a CPW: A partnership between Universities and one or several companies, purposes of it are first to increase health, well being, companies teams competencies, and competitiveness, second to train the "IPOD generation" to include risks prevention in design. 2) How does it work? CPW allows cooperation between experience and new insight through inductive methods. This model follows the Piaget (1) philosophy linking concrete world to abstraction by a learning system associating realization and abstraction. 3) Is it successful? In order to answer this third question we will show examples of studies and models performed during CPWs.It appears that the CPWs produce visible results in companies such as new process designs, new methods, and also changes in lectures. However some less visible results remain unclear: How the company personnel evolve during and after CPW? Does CPW motivate our future engineers enough to continuously improve their skills in risk prevention and innovative design?

  9. Problem Solution Processes of Musicians and Engineers: What do Their Approaches Look Like

    Directory of Open Access Journals (Sweden)

    Säde-Pirkko Nissilä

    2015-06-01

    Full Text Available PBL is learning through becoming conscious of practical and abstract problems and finding ways how to solve them. It can be a pattern which doesn’t follow traditional divisions of disciplines. In this article the material was collected from two, in the first sight, very different groups. One was music students (N = 62 who had to learn to solve various practical and theoretical problems in preparing a program for a series of concerts as collective and individual action. The method used was the 7-step method which divides learning into seven phases proceeding from creating the social frame of reference and mental models (steps 1–4 through actual work (steps 5–6 to the evaluation of the outcomes (step 7. Another group consisted of international, multicultural business leaders in engineering (N = 6. In using earlier the 7-step method, the approaches resembled those of the music students: deepening their professional competences. To engage their ability to use imagination and connect reality with brainstorming and mental flexibility, the creative PBL method 635 was used. Three practical problems were solved so that the solutions included new viewpoints which would be applied to meet the real needs in the near future. The results show that not only were the learning targets of both groups reached but, with reflection included, the processes widened the professional competences of the participants.

  10. An engineering approach to dry friction behaviour of numerous engineering plastics with respect to the mechanical properties

    Directory of Open Access Journals (Sweden)

    G. Kalacska

    2013-02-01

    Full Text Available Twenty-one different commercial-grade engineering polymers, including virgin and composite types, were selected for testing, based on mechanical engineering practices. Three groups were formed according to typical applications: 1 Sliding machine element materials; 2 Mechanically load-carrying machine element materials that are often subjected to friction and wear effects; and 3 Additional two amorphous materials used as chemically resistant materials that have rare sliding load properties. The friction running-in state was tested using a dynamic pin-on-plate test rig. During steady-state friction tests, two pv regimes (0.8 and 2 MPa"ms–1 were analysed by a pin-on-disc test system. Based on the measured forces on ground structural steel, surface friction coefficients were calculated and analysed with respect to the mechanical effects of friction. The friction results were evaluated by the measured mechanical properties: yield stress, Shore D hardness, Young’s modulus and elongation at the break. The three material groups exhibited different trends in friction with respect to changing mechanical properties. Linear (with varying positive and negative slopes, logarithmic and exponential relationships were observed, and occasionally there were no effects observed. At steady-state friction, the elongation at the break had less effect on the friction coefficients. The dynamic sliding model, which correlates better to real machine element applications, showed that increasing hardness and yield stress decreases friction. During steady-state friction, an increase in pv regime often changed the sign of the linear relationship between the material property and the friction, which agrees with the frictional theory of polymer/steel sliding pairs.

  11. Engineered phages for electronics.

    Science.gov (United States)

    Cui, Yue

    2016-11-15

    Phages are traditionally widely studied in biology and chemistry. In recent years, engineered phages have attracted significant attentions for functionalization or construction of electronic devices, due to their specific binding, catalytic, nucleating or electronic properties. To apply the engineered phages in electronics, these are a number of interesting questions: how to engineer phages for electronics? How are the engineered phages characterized? How to assemble materials with engineered phages? How are the engineered phages micro or nanopatterned? What are the strategies to construct electronics devices with engineered phages? This review will highlight the early attempts to address these questions and explore the fundamental and practical aspects of engineered phages in electronics, including the approaches for selection or expression of specific peptides on phage coat proteins, characterization of engineered phages in electronics, assembly of electronic materials, patterning of engineered phages, and construction of electronic devices. It provides the methodologies and opens up ex-cit-ing op-por-tu-ni-ties for the development of a variety of new electronic materials and devices based on engineered phages for future applications. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Uncovering the Layers of Design Processes of a Global Undergraduate Engineering Course: An Interactional Ethnographic Approach

    Science.gov (United States)

    Joo, Jenna (Ji Eun)

    This dissertation presents an ethnographic study of an instructor's design logic and thinking underlying a global, multi-country undergraduate engineering design course. The study analyzed how, in what ways, and for what purposes, he continually defined and reformulated what counted as (Heap, 1991) "new" learning opportunities and outcomes for engineering design thinking in the 21st century, through his interactions with globally distributed groups of students and teaching teams (i.e., US, India, Israel, China and South Korea). By examining what was discursively made present to students in moment-by-moment and over-time, I identified the processes and practices that members of the class needed to know, understand, produce and engage in (Heath & Street, 2008) to develop their capacities to work in intercultural contexts on local design problems. Discourse analysis guided by an Interactional Ethnographic logic-in-use (Birdwhistell, 1977), grounded in a social construction of knowledge perspective (i.e., Green, Skukauskaite, and Baker, 2012; Castanheira, Crawford, Dixon and Green, 2001), framed the ways in which I examined the work of participants, what they oriented to and were held accountable for, and how what counted as this "new" instructional approach was socially constructed (Heap, 1991; Bloome & Egan-Robertson, 1993, Castanheira et al, 2001). This inquiry process required consideration of multimodal texts available to students in different technology-enabled educational contexts, public (re)presentations of this developing program as well as the construction of transcripts. From this perspective, texts were spoken, written and/or published works (Bakhtin, 1986) constructed by key actors (the designer, the support team, a teaching assistant and students). The analyses made visible how the instructor's discourse focused students on taking a problem-oriented approach to resolving challenges in working interculturally on a common task (e.g., the design thinking

  13. Fault Detection of Inline Reciprocating Diesel Engine: A Mass and Gas-Torque Approach

    Directory of Open Access Journals (Sweden)

    S. H. Gawande

    2012-01-01

    Full Text Available Early fault detection and diagnosis for medium-speed diesel engines are important to ensure reliable operation throughout the course of their service. This work presents an investigation of the diesel engine combustion-related fault detection capability of crankshaft torsional vibrations. Proposed methodology state the way of early fault detection in the operating six-cylinder diesel engine. The model of six cylinders DI Diesel engine is developed appropriately. As per the earlier work by the same author the torsional vibration amplitudes are used to superimpose the mass and gas torque. Further mass and gas torque analysis is used to detect fault in the operating engine. The DFT of the measured crankshaft’s speed, under steady-state operating conditions at constant load shows significant variation of the amplitude of the lowest major harmonic order. This is valid both for uniform operating and faulty conditions and the lowest harmonic orders may be used to correlate its amplitude to the gas pressure torque and mass torque for a given engine. The amplitudes of the lowest harmonic orders (0.5, 1, and 1.5 of the gas pressure torque and mass torque are used to map the fault. A method capable to detect faulty cylinder of operating Kirloskar diesel engine of SL90 Engine-SL8800TA type is developed, based on the phases of the lowest three harmonic orders.

  14. An Interactive Simulator-Based Pedagogical (ISP) Approach for Teaching Microcontrollers in Engineering Programs

    Science.gov (United States)

    Tang, Shensheng

    2014-01-01

    Microcontrollers is a required course in most Electrical, Computer, and Mechanic Engineering (Technology) programs at U.S. universities. Most engineering courses (e.g., microcontrollers), by nature, introduce abstract concepts, definitions, and models, and use primarily lectures and readings (words, symbols) to transmit information. This…

  15. Cycle-skipping strategies for pumping loss reduction in spark ignition engines: An experimental approach

    International Nuclear Information System (INIS)

    Yüksek, Levent; Özener, Orkun; Sandalcı, Tarkan

    2012-01-01

    Highlights: ► A cycle density variation technique called cycle-skipping was applied. ► Effect on fuel consumption and gaseous emissions was investigated. ► Fuel consumption and gaseous tail-pipe emissions improved at partial loading conditions. - Abstract: Spark ignition (SI) engines are widely used for power generation, especially in the automotive industry. SI engines have a lower thermal efficiency than diesel engines due to a lower compression ratio, higher charge-induction work and lower end of compression stroke pressure. A significant amount of charge induction work is lost when an SI engine runs under partial loading conditions. Under partial loading conditions, a lower intake charge is required, which can be theoretically achieved by varying the displacement volume or the stroke number of the engine without using a throttle. Reducing the displacement volume to control the engine load can be achieved by skipping cycles in single-cylinder engines. This study investigates the effect of cycle-skipping strategies on the brake specific fuel consumption (BSFC) and exhaust emissions of an SI engine under partial loading conditions. Three different skipping modes were applied: normal, normal-skip and normal-normal-skip. A significant improvement in BSFC and carbon monoxide emission was obtained by applying cycle-skipping strategies.

  16. An eLearning Standard Approach for Supporting PBL in Computer Engineering

    Science.gov (United States)

    Garcia-Robles, R.; Diaz-del-Rio, F.; Vicente-Diaz, S.; Linares-Barranco, A.

    2009-01-01

    Problem-based learning (PBL) has proved to be a highly successful pedagogical model in many fields, although it is not that common in computer engineering. PBL goes beyond the typical teaching methodology by promoting student interaction. This paper presents a PBL trial applied to a course in a computer engineering degree at the University of…

  17. Some Practical Approaches to a Course on Paraconsistent Logic for Engineers

    Science.gov (United States)

    Lambert-Torres, Germano; de Moraes, Carlos Henrique Valerio; Coutinho, Maurilio Pereira; Martins, Helga Gonzaga; Borges da Silva, Luiz Eduardo

    2017-01-01

    This paper describes a non-classical logic course primarily indicated for graduate students in electrical engineering and energy engineering. The content of this course is based on the vision that it is not enough for a student to indefinitely accumulate knowledge; it is necessary to explore all the occasions to update, deepen, and enrich that…

  18. Reverse engineering of industrially relevant phenotypes in yeast : An integrated approach

    NARCIS (Netherlands)

    Oud, B.

    2013-01-01

    Reverse engineering is the study of discovering the structure, function and operation of a device or system with the express aim to reconstruct its key functionalities. This principle is applied to many disciplines, from military, through computer engineering, to health, but also in metabolic

  19. A Strategic Approach for Supporting the Future of Civil Engineering Education in Europe

    Science.gov (United States)

    Angelides, Demos C.; Loukogeorgaki, Eva

    2005-01-01

    A new strategic vision of the extensively debated European higher education is proposed with focus on civil engineering. Civil engineering education for the future is considered with relevance to potential world-wide trends and anticipated societal requirements and, therefore, required employee qualifications of the construction-related providers…

  20. A Systematic Approach to Teaching Critical Thinking Skills to Electrical and Computer Engineering Undergraduates

    Science.gov (United States)

    Welch, Karla Conn; Hieb, Jeffrey; Graham, James

    2015-01-01

    Coursework that instills patterns of rigorous logical thought has long been a hallmark of the engineering curriculum. However, today's engineering students are expected to exhibit a wider range of thinking capabilities both to satisfy ABET requirements and to prepare the students to become successful practitioners. This paper presents the initial…

  1. The Romanian educational system in nuclear engineering field - experience and new approaches

    International Nuclear Information System (INIS)

    Dragusin, O.; Burghelea, A.

    2001-01-01

    In this paper we would like to present the actual status of the education in the nuclear engineering field at 'Pantholic' University Bucharest, Romania, Power Engineering Faculty, Nuclear Power Plant Department, and also the efforts of integration of the educational system of Romania into the international system and the development of new concepts concerning the education of the new specialists generation. (authors)

  2. An Effective Industry-Based Mentoring Approach for the Recruitment of Women and Minorities in Engineering

    Science.gov (United States)

    Ilumoka, Abby; Milanovic, Ivana; Grant, Natalie

    2017-01-01

    This article reflects upon an investigative study of the powerful impact that mentoring partnerships have on pre-college students and young engineering professionals in Hartford, CT. It was found that these partnerships can provide very strong foundations for a diverse pre-college student engineering pipeline that includes significant numbers of…

  3. New Challenging Approaches to Engineering Education: Enhancing University-Industry Co-Operation

    Science.gov (United States)

    Korhonen-Yrjanheikki, Kati; Tukiainen, Taina; Takala, Minna

    2007-01-01

    Globalization, accelerated time-based competition, qualitative dynamics, rapid development of technology and especially Information and Communications Technology (ICT) developments challenge engineering education and capability development of each engineer. The success and the competitiveness of companies are increasingly based on their employees.…

  4. Introduction of Sustainability Concepts into Industrial Engineering Education: A Modular Approach

    Science.gov (United States)

    Nazzal, Dima; Zabinski, Joseph; Hugar, Alexander; Reinhart, Debra; Karwowski, Waldemar; Madani, Kaveh

    2015-01-01

    Sustainability in operations, production, and consumption continues to gain relevance for engineers. This trend will accelerate as demand for goods and services grows, straining resources and requiring ingenuity to replace boundless supply in meeting the needs of a more crowded, more prosperous world. Industrial engineers are uniquely positioned…

  5. Computer-Aided Software Engineering - An approach to real-time software development

    Science.gov (United States)

    Walker, Carrie K.; Turkovich, John J.

    1989-01-01

    A new software engineering discipline is Computer-Aided Software Engineering (CASE), a technology aimed at automating the software development process. This paper explores the development of CASE technology, particularly in the area of real-time/scientific/engineering software, and a history of CASE is given. The proposed software development environment for the Advanced Launch System (ALS CASE) is described as an example of an advanced software development system for real-time/scientific/engineering (RT/SE) software. The Automated Programming Subsystem of ALS CASE automatically generates executable code and corresponding documentation from a suitably formatted specification of the software requirements. Software requirements are interactively specified in the form of engineering block diagrams. Several demonstrations of the Automated Programming Subsystem are discussed.

  6. Fuel Continuous Mixer ? an Approach Solution to Use Straight Vegetable Oil for Marine Diesel Engines

    Directory of Open Access Journals (Sweden)

    Đặng Van Uy

    2018-03-01

    Full Text Available The vegetable oil is well known as green fuel for diesel engines due to its low sunphur content and renewable stock. However, there are some problems raising when vegetable oil is used as fuel for diesel engines such as highly effected by cold weather, lower general efficiency, separation in layer if mixed with diesel oil and so on. To overcome that disadvantiges, the authors propose a new idea that to use a continuous fuel mixer to blend vegetable oil with diesel oil to make so called a mixed fuel supplying to diesel engines inline. In order to ensure a quality of the mixed fuel created by continuous mixer, a homogeneous testing was introduced with believable results. Then, the continuous mixer has been installed into fuel supply system of diesel engine 6LU32 at a lab of Vietnam Maritime University in terms of checking a real operation of the fuel continuous mixer with diesel engine.

  7. An integrated approach for the in vitro dosimetry of engineered nanomaterials

    Science.gov (United States)

    2014-01-01

    Background There is a great need for screening tools capable of rapidly assessing nanomaterial toxicity. One impediment to the development of reliable in vitro screening methods is the need for accurate measures of cellular dose. We present here a methodology that enables accurate determination of delivered to cell dose metrics. This methodology includes (1) standardization of engineered nanomaterial (ENM) suspension preparation; (2) measurement of ENM characteristics controlling delivery to cells in culture; and (3) calculation of delivered dose as a function of exposure time using the ISDD model. The approach is validated against experimentally measured doses, and simplified analytical expressions for the delivered dose (Relevant In Vitro Dose (RID)f function) are derived for 20 ENMs. These functions can be used by nanotoxicologists to accurately calculate the total mass (RIDM), surface area (RIDSA), or particle number (RIDN) delivered to cells as a function of exposure time. Results The proposed methodology was used to derive the effective density, agglomerate diameter and RID functions for 17 industrially-relevant metal and metal oxide ENMs, two carbonaceous nanoparticles, and non-agglomerating gold nanospheres, for two well plate configurations (96 and 384 well plates). For agglomerating ENMs, the measured effective density was on average 60% below the material density. We report great variability in delivered dose metrics, with some materials depositing within 24 hours while others require over 100 hours for delivery to cells. A neutron-activated tracer particle system was employed to validate the proposed in vitro dosimetry methodology for a number of ENMs (measured delivered to cell dose within 9% of estimated). Conclusions Our findings confirm and extend experimental and computational evidence that agglomerate characteristics affect the dose delivered to cells. Therefore measurement of these characteristics is critical for effective use of in vitro systems

  8. Exploring Barriers to Medication Safety in an Ethiopian Hospital Emergency Department: A Human Factors Engineering Approach

    Directory of Open Access Journals (Sweden)

    Ephrem Abebe

    2018-02-01

    Full Text Available Objective: To describe challenges associated with the medication use process and potential medication safety hazards in an Ethiopian hospital emergency department using a human factors approach. Methods: We conducted a qualitative study employing observations and semi-structured interviews guided by the Systems Engineering Initiative for Patient Safety model of work system as an analytical framework. The study was conducted in the emergency department of a teaching hospital in Ethiopia. Study participants included resident doctors, nurses, and pharmacists. We performed content analysis of the qualitative data using accepted procedures. Results: Organizational barriers included communication failures, limited supervision and support for junior staff contributing to role ambiguity and conflict. Compliance with documentation policy was minimal. Task related barriers included frequent interruptions and work-related stress resulting from job requirements to continuously prioritize the needs of large numbers of patients and family members. Person related barriers included limited training and work experience. Work-related fatigue due to long working hours interfered with staff’s ability to document and review medication orders. Equipment breakdowns were common as were non-calibrated or poorly maintained medical devices contributing to erroneous readings. Key environment related barriers included overcrowding and frequent interruption of staff’s work. Cluttering of the work space compounded the problem by impeding efforts to locate medications, medical supplies or medical charts. Conclusions: Applying a systems based approach allows a context specific understanding of medication safety hazards in EDs from low-income countries. When developing interventions to improve medication and overall patient safety, health leaders should consider the interactions of the different factors. Conflict of Interest We declare no conflicts of interest or

  9. Applied Laplace transforms and z-transforms for scientists and engineers a computational approach using a Mathematica package

    CERN Document Server

    Graf, Urs

    2004-01-01

    The theory of Laplace transformation is an important part of the mathematical background required for engineers, physicists and mathematicians. Laplace transformation methods provide easy and effective techniques for solving many problems arising in various fields of science and engineering, especially for solving differential equations. What the Laplace transformation does in the field of differential equations, the z-transformation achieves for difference equations. The two theories are parallel and have many analogies. Laplace and z­ transformations are also referred to as operational calculus, but this notion is also used in a more restricted sense to denote the operational calculus of Mikusinski. This book does not use the operational calculus of Mikusinski, whose approach is based on abstract algebra and is not readily accessible to engineers and scientists. The symbolic computation capability of Mathematica can now be used in favor of the Laplace and z-transformations. The first version of the Mathema...

  10. Space Station Freedom - Configuration management approach to supporting concurrent engineering and total quality management. [for NASA Space Station Freedom Program

    Science.gov (United States)

    Gavert, Raymond B.

    1990-01-01

    Some experiences of NASA configuration management in providing concurrent engineering support to the Space Station Freedom program for the achievement of life cycle benefits and total quality are discussed. Three change decision experiences involving tracing requirements and automated information systems of the electrical power system are described. The potential benefits of concurrent engineering and total quality management include improved operational effectiveness, reduced logistics and support requirements, prevention of schedule slippages, and life cycle cost savings. It is shown how configuration management can influence the benefits attained through disciplined approaches and innovations that compel consideration of all the technical elements of engineering and quality factors that apply to the program development, transition to operations and in operations. Configuration management experiences involving the Space Station program's tiered management structure, the work package contractors, international partners, and the participating NASA centers are discussed.

  11. Study of Modern Approach to Build the Functional Models of Managerial and Engineering Systems in Training Specialists for Space Industry

    Directory of Open Access Journals (Sweden)

    N. V. Arhipova

    2016-01-01

    Full Text Available The SM8 Chair at Bauman Moscow State Technological University (BMSTU trains specialists majoring not only in design and manufacture, but also in operation and maintenance of space ground-based infrastructure.The learning courses in design, production, and operation of components of the missile and space technology, give much prominence to modeling. The same attention should be given to the modeling of managerial and engineering systems, with which deal both an expert and a leadman. It is important to choose the modeling tools for managerial and engineering systems with which they are to work and to learn how to apply these tools.The study of modern approach to functional modeling of managerial and engineering systems is held in the format of business game in laboratory class. A structural analysis and design technique (IDEFØ is considered as the means of modeling.The article stresses the IDEFØ approach advantages, namely: comprehensible graphical language, applicability to all-types and all-levels-of-hierarchy managerial and engineering systems modeling, popularity, version control means, teamwork tools. Moreover, the IDEFØ allows us to illustrate such notions, as point of view, system bounders, structure, control, feedback as applied to the managerial and engineering systems.The article offers a modified procedure to create an IDEFØ model in the context of training session. It also suggests a step-by-step procedure of the instruction session to be held, as well as of student self-training to have study credits, and a procedure of the work defense (final test.The approach under consideration can be applied to other training courses. The article proves it giving information about positive experience of its application.

  12. A transient tribodynamic approach for the calculation of internal combustion engine piston slap noise

    Science.gov (United States)

    Dolatabadi, N.; Littlefair, B.; De la Cruz, M.; Theodossiades, S.; Rothberg, S. J.; Rahnejat, H.

    2015-09-01

    An analytical/numerical methodology is presented to calculate the radiated noise due to internal combustion engine piston impacts on the cylinder liner through a film of lubricant. Both quasi-static and transient dynamic analyses coupled with impact elasto-hydrodynamics are reported. The local impact impedance is calculated, as well as the transferred energy onto the cylinder liner. The simulations are verified against experimental results for different engine operating conditions and for noise levels calculated in the vicinity of the engine block. Continuous wavelet signal processing is performed to identify the occurrence of piston slap noise events and their spectral content, showing good conformance between the predictions and experimentally acquired signals.

  13. Most common road safety engineering deficiencies in South Eastern Europe as a part of safe system approach

    Science.gov (United States)

    Jovanov, D.; Vollpracht, H. J.; Beles, H.; Popa, V.; Tolea, B. A.

    2017-10-01

    Most common road safety engineering deficiencies identified by the authors in South Eastern Europe, including Romania, have been collected together and presented in this paper as a part of road safety unbreakably connected to the safe system approach (driver-vehicle-road). In different South Eastern Europe countries Road Safety Audit (RSA), Road Safety Inspection (RSI), as well as Black Spot Management (BSM) was introduced and practical implementation experience enabled the authors to analyze the road safety problems. Typical road safety engineering deficiencies have been presented in 8 different subsections, based on PIARC (World Road Association) RSA approach. This paper presents collected common road safety problems with relevant illustrations (real pictures) with associated accident risks.

  14. Information Flow Through Stages of Complex Engineering Design Projects: A Dynamic Network Analysis Approach

    DEFF Research Database (Denmark)

    Parraguez, Pedro; Eppinger, Steven D.; Maier, Anja

    2015-01-01

    The pattern of information flow through the network of interdependent design activities is thought to be an important determinant of engineering design process results. A previously unexplored aspect of such patterns relates to the temporal dynamics of information transfer between activities...... information flows between activities in complex engineering design projects; 2) we show how the network of information flows in a large-scale engineering project evolved over time and how network analysis yields several managerial insights; and 3) we provide a useful new representation of the engineering...... as those activities are implemented through the network of people executing the project. To address this gap, we develop a dynamic modeling method that integrates both the network of people and the network of activities in the project. We then employ a large dataset collected from an industrial setting...

  15. Geomorphic Approach to Regional Sediment Management in Engineered and Restored Fluvial Systems

    National Research Council Canada - National Science Library

    Thorne, Colin

    2001-01-01

    This document reviews contemporary practice in regional sediment management. It examines whether catchment wide sediment issues have been considered in the design of engineering and restoration/rehabilitation projects...

  16. Development of an engineered cementitious composite to enhance bridge approach slab durability.

    Science.gov (United States)

    2013-06-01

    The strength and durability of highway bridges are two of the key components in maintaining a : high level of freight transportation capacity on the nations highways. : The CFIRE project 04-09 demonstrated the feasibility of a new hybrid engineered...

  17. A Systems Engineering Approach to Address Human Capital Management Issues in the Shipbuilding Industry

    National Research Council Canada - National Science Library

    Todd, Hal M; Parten, Douglas S

    2008-01-01

    .... This study investigated current DoD Human Capital Management (HCM) strategies for attracting, developing, retaining, and managing competencies and intellectual resources for science and engineering talent within the shipbuilding industry...

  18. An Engineering Approach to Management of Occupational and Community Noise Exposure at NASA Lewis Research Center

    Science.gov (United States)

    Cooper, Beth A.

    1997-01-01

    Workplace and environmental noise issues at NASA Lewis Research Center are effectively managed via a three-part program that addresses hearing conservation, community noise control, and noise control engineering. The Lewis Research Center Noise Exposure Management Program seeks to limit employee noise exposure and maintain community acceptance for critical research while actively pursuing engineered controls for noise generated by more than 100 separate research facilities and the associated services required for their operation.

  19. MSblender: A probabilistic approach for integrating peptide identifications from multiple database search engines.

    Science.gov (United States)

    Kwon, Taejoon; Choi, Hyungwon; Vogel, Christine; Nesvizhskii, Alexey I; Marcotte, Edward M

    2011-07-01

    Shotgun proteomics using mass spectrometry is a powerful method for protein identification but suffers limited sensitivity in complex samples. Integrating peptide identifications from multiple database search engines is a promising strategy to increase the number of peptide identifications and reduce the volume of unassigned tandem mass spectra. Existing methods pool statistical significance scores such as p-values or posterior probabilities of peptide-spectrum matches (PSMs) from multiple search engines after high scoring peptides have been assigned to spectra, but these methods lack reliable control of identification error rates as data are integrated from different search engines. We developed a statistically coherent method for integrative analysis, termed MSblender. MSblender converts raw search scores from search engines into a probability score for every possible PSM and properly accounts for the correlation between search scores. The method reliably estimates false discovery rates and identifies more PSMs than any single search engine at the same false discovery rate. Increased identifications increment spectral counts for most proteins and allow quantification of proteins that would not have been quantified by individual search engines. We also demonstrate that enhanced quantification contributes to improve sensitivity in differential expression analyses.

  20. Enhancing vehicle’s engine warm up using integrated mechanical approach

    Science.gov (United States)

    Ibrahim, T. M.; Syahir, A. Z.; Zulkifli, N. W. M.; Masjuki, H. H.; Osman, A.

    2017-06-01

    Transportation sector covers a large portion of the total energy consumption shares and is highly associated to global warming. Growing concern over the harmful gases being emitted from vehicles and their environmental implications has urged the need for pollutant reduction through more efficient engines. Good engine thermal management especially during cold-start warm up phase has been proven to enhance the engine efficiency in terms of fuel economy and greenhouse emissions specifically. In this study, the viability engine split cooling system was tested in two separate test. The parameters of interest include coolant and transmission temperature as these both parameters indicate the internal engine condition and highly associated with engine efficiency. In the first idle test, coolant temperature within the modified cooling configuration reached the optimum coolant temperature of 60 °C about 41.28% faster when compared to baseline configuration. The modified configuration also heat up the transmission oil around 4 times faster. In the second NEDC test which simulates the real time driving condition, the coolant of the modified vehicle reached the optimum temperature around 28.26% compared to the baseline.

  1. Seeding cell approach for tissue-engineered urethral reconstruction in animal study: A systematic review and meta-analysis.

    Science.gov (United States)

    Xue, Jing-Dong; Gao, Jing; Fu, Qiang; Feng, Chao; Xie, Hong

    2016-07-01

    We systematically reviewed published preclinical studies to evaluate the effectiveness of cell-seeded tissue engineering approach for urethral reconstruction in an animal model. The outcomes were summarized by success factors in the animal experiments, which evaluate the possibility and feasibility of a clinical application in the future. Preclinical studies of tissue engineering approaches for urethral reconstruction were identified through a systematic search in PubMed, Embase, and Biosis Previews (web of science SP) databases for studies published from 1 January 1980 to 23 November 2014. Primary studies were included if urethral reconstruction was performed using a tissue-engineered biomaterial in any animal species (with the experiment group being a cell-seeded scaffold and the control group being a cell-free scaffold) with histology and urethrography as the outcome measure. A total of 15 preclinical studies were included in our meta-analysis. The histology and urethrography outcome between the experimental and control groups were considered to be the most clinically relevant. Through this systematic approach, our outcomes suggested that applying the cell-seeded biomaterial in creating a neo-urethra was stable and effective. And multi-type cells including epithelial cells as well as smooth muscle cells or fibroblasts seemed to be a better strategy. Stem cells, especially after epithelial differentiation, could be a promising choice for future researches. © 2016 by the Society for Experimental Biology and Medicine.

  2. An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions.

    Science.gov (United States)

    Kinder, Michelle; Greenplate, Allison R; Strohl, William R; Jordan, Robert E; Brezski, Randall J

    2015-01-01

    Cytotoxic therapeutic monoclonal antibodies (mAbs) often mediate target cell-killing by eliciting immune effector functions via Fc region interactions with cellular and humoral components of the immune system. Key functions include antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC). However, there has been increased appreciation that along with cell-killing functions, the induction of antibody-dependent cytokine release (ADCR) can also influence disease microenvironments and therapeutic outcomes. Historically, most Fc engineering approaches have been aimed toward modulating ADCC, ADCP, or CDC. In the present study, we describe an Fc engineering approach that, while not resulting in impaired ADCC or ADCP, profoundly affects ADCR. As such, when peripheral blood mononuclear cells are used as effector cells against mAb-opsonized tumor cells, the described mAb variants elicit a similar profile and quantity of cytokines as IgG1. In contrast, although the variants elicit similar levels of tumor cell-killing as IgG1 with macrophage effector cells, the variants do not elicit macrophage-mediated ADCR against mAb-opsonized tumor cells. This study demonstrates that Fc engineering approaches can be employed to uncouple macrophage-mediated phagocytic and subsequent cell-killing functions from cytokine release.

  3. A fault diagnosis approach for diesel engine valve train based on improved ITD and SDAG-RVM

    International Nuclear Information System (INIS)

    Yu, Liu; Junhong, Zhang; Fengrong, Bi; Jiewei, Lin; Wenpeng, Ma

    2015-01-01

    Targeting the non-stationary characteristics of the vibration signals of a diesel engine valve train, and the limitation of the autoregressive (AR) model, a novel approach based on the improved intrinsic time-scale decomposition (ITD) and relevance vector machine (RVM) is proposed in this paper for the identification of diesel engine valve train faults. The approach mainly consists of three stages: First, prior to the feature extraction, non-uniform B-spline interpolation is introduced to the ITD method for the fitting of baseline signal, then the improved ITD is used to decompose the non-stationary signals into a set of stationary proper rotation components (PRCs). Second, the AR model is established for each PRC, and the first several AR coefficients together with the remnant variance of all PRCs are regarded as the fault feature vectors. Finally, a new separability based directed acyclic graph (SDAG) method is proposed to determine the structure of multi-class RVM, and the fault feature vectors are classified using the SDAG-RVM classifier to recognize the fault of the diesel engine valve train. The experimental results demonstrate that the proposed fault diagnosis approach can effectively extract the fault features and accurately identify the fault patterns. (paper)

  4. Tissue engineering in dentistry.

    Science.gov (United States)

    Abou Neel, Ensanya Ali; Chrzanowski, Wojciech; Salih, Vehid M; Kim, Hae-Won; Knowles, Jonathan C

    2014-08-01

    of this review is to inform practitioners with the most updated information on tissue engineering and its potential applications in dentistry. The authors used "PUBMED" to find relevant literature written in English and published from the beginning of tissue engineering until today. A combination of keywords was used as the search terms e.g., "tissue engineering", "approaches", "strategies" "dentistry", "dental stem cells", "dentino-pulp complex", "guided tissue regeneration", "whole tooth", "TMJ", "condyle", "salivary glands", and "oral mucosa". Abstracts and full text articles were used to identify causes of craniofacial tissue loss, different approaches for craniofacial reconstructions, how the tissue engineering emerges, different strategies of tissue engineering, biomaterials employed for this purpose, the major attempts to engineer different dental structures, finally challenges and future of tissue engineering in dentistry. Only those articles that dealt with the tissue engineering in dentistry were selected. There have been a recent surge in guided tissue engineering methods to manage periodontal diseases beyond the traditional approaches. However, the predictable reconstruction of the innate organisation and function of whole teeth as well as their periodontal structures remains challenging. Despite some limited progress and minor successes, there remain distinct and important challenges in the development of reproducible and clinically safe approaches for oral tissue repair and regeneration. Clearly, there is a convincing body of evidence which confirms the need for this type of treatment, and public health data worldwide indicates a more than adequate patient resource. The future of these therapies involving more biological approaches and the use of dental tissue stem cells is promising and advancing. Also there may be a significant interest of their application and wider potential to treat disorders beyond the craniofacial region. Considering the

  5. Engineered Biosynthesis of Plant Polyketides: Structure-Based and Precursor-Directed Approach

    Science.gov (United States)

    Abe, Ikuro

    benzoyl-CoA as a starter substrate. These results suggested that the engineered biosynthesis of plant polyketides by combination of the structure-based and the precursor-directed approach would lead to further production of chemically and structurally divergent unnatural novel polyketides.

  6. A tissue engineering approach to anterior cruciate ligament regeneration using novel shaped capillary channel polymer fibers

    Science.gov (United States)

    Sinclair, Kristofer D.

    2009-12-01

    Ruptures of the anterior cruciate ligament (ACL) are the most frequent of injuries to the knee due to its role in preventing anterior translation of the tibia. It is estimated that as many as 200,000 Americans per year will suffer from a ruptured ACL, resulting in management costs on the order of 5 billion dollars. Without treatment these patients are unable to return to normal activity, as a consequence of the joint instability found within the ACL deficient knee. Over the last thirty years, a variety of non-degradable, synthetic fibers have been evaluated for their use in ACL reconstruction; however, a widely accepted prosthesis has been unattainable due to differences in mechanical properties of the synthetic graft relative to the native tissue. Tissue engineering is an interdisciplinary field charged with the task of developing therapeutic solutions for tissue and organ failure by enhancing the natural wound healing process through the use of cellular transplants, biomaterials, and the delivery of bioactive molecules. The capillary channel polymer (CC-P) fibers used in this research were fabricated by melt extrusion from polyethylene terephthalate and polybutylene terephthalate. These fibers possess aligned micrometer scale surface channels that may serve as physical templates for tissue growth and regeneration. This inherent surface topography offers a unique and industrially viable approach for cellular contact guidance on three dimensional constructs. In this fundamental research the ability of these fiber channels to support the adhesion, alignment, and organization of fibroblasts was demonstrated and found to be superior to round fiber controls. The results demonstrated greater uniformity of seeding and accelerated formation of multi-layered three-dimensional biomass for the CC-P fibers relative to those with a circular cross-section. Furthermore, the CC-P geometry induced nuclear elongation consistent with that observed in native ACL tissue. Through the

  7. Universal Approach toward Hysteresis-Free Perovskite Solar Cell via Defect Engineering.

    Science.gov (United States)

    Son, Dae-Yong; Kim, Seul-Gi; Seo, Ja-Young; Lee, Seon-Hee; Shin, Hyunjung; Lee, Donghwa; Park, Nam-Gyu

    2018-01-31

    Organic-inorganic halide perovskite is believed to be a potential candidate for high efficiency solar cells because power conversion efficiency (PCE) was certified to be more than 22%. Nevertheless, mismatch of PCE due to current density (J)-voltage (V) hysteresis in perovskite solar cells is an obstacle to overcome. There has been much lively debate on the origin of J-V hysteresis; however, effective methodology to solve the hysteric problem has not been developed. Here we report a universal approach for hysteresis-free perovskite solar cells via defect engineering. A severe hysteresis observed from the normal mesoscopic structure employing TiO 2 and spiro-MeOTAD is almost removed or does not exist upon doping the pure perovskites, CH 3 NH 3 PbI 3 and HC(NH 2 ) 2 PbI 3 , and the mixed cation/anion perovskites, FA 0.85 MA 0.15 PbI 2.55 Br 0.45 and FA 0.85 MA 0.1 Cs 0.05 PbI 2.7 Br 0.3 , with potassium iodide. Substantial reductions in low-frequency capacitance and bulk trap density are measured from the KI-doped perovskite, which is indicative of trap-hysteresis correlation. A series of experiments with alkali metal iodides of LiI, NaI, KI, RbI and CsI reveals that potassium ion is the right element for hysteresis-free perovskite. Theoretical studies suggest that the atomistic origin of the hysteresis of perovskite solar cells is not the migration of iodide vacancy but results from the formation of iodide Frenkel defect. Potassium ion is able to prevent the formation of Frenkel defect since K + energetically prefers the interstitial site. A complete removal of hysteresis is more pronounced at mixed perovskite system as compared to pure perovskites, which is explained by lower formation energy of K interstitial (-0.65 V for CH 3 NH 3 PbI 3 vs -1.17 V for mixed perovskite). The developed KI doping methodology is universally adapted for hysteresis-free perovskite regardless of perovskite composition and device structure.

  8. Chemical and engineering approaches to enable organic field-effect transistors for electronic skin applications.

    Science.gov (United States)

    Sokolov, Anatoliy N; Tee, Benjamin C-K; Bettinger, Christopher J; Tok, Jeffrey B-H; Bao, Zhenan

    2012-03-20

    Skin is the body's largest organ and is responsible for the transduction of a vast amount of information. This conformable material simultaneously collects signals from external stimuli that translate into information such as pressure, pain, and temperature. The development of an electronic material, inspired by the complexity of this organ is a tremendous, unrealized engineering challenge. However, the advent of carbon-based electronics may offer a potential solution to this long-standing problem. In this Account, we describe the use of an organic field-effect transistor (OFET) architecture to transduce mechanical and chemical stimuli into electrical signals. In developing this mimic of human skin, we thought of the sensory elements of the OFET as analogous to the various layers and constituents of skin. In this fashion, each layer of the OFET can be optimized to carry out a specific recognition function. The separation of multimodal sensing among the components of the OFET may be considered a "divide and conquer" approach, where the electronic skin (e-skin) can take advantage of the optimized chemistry and materials properties of each layer. This design of a novel microstructured gate dielectric has led to unprecedented sensitivity for tactile pressure events. Typically, pressure-sensitive components within electronic configurations have suffered from a lack of sensitivity or long mechanical relaxation times often associated with elastomeric materials. Within our method, these components are directly compatible with OFETs and have achieved the highest reported sensitivity to date. Moreover, the tactile sensors operate on a time scale comparable with human skin, making them ideal candidates for integration as synthetic skin devices. The methodology is compatible with large-scale fabrication and employs simple, commercially available elastomers. The design of materials within the semiconductor layer has led to the incorporation of selectivity and sensitivity within

  9. New approaches for combustion sensing on prototyping engine control unit; Fahrzeugtaugliches Prototypen-Motorsteuergeraet mit Brennverlaufserfassung

    Energy Technology Data Exchange (ETDEWEB)

    Drmic, A.; Burkardt, D. [AFT Atlas Fahrzeugtechnik GmbH, Werdohl (Germany)

    2008-07-01

    Further development of the established combustion engine still offers potential, that is both important and achievable in the medium-term, in tackling the problem of rising raw material costs and ever-tougher emissions limits. Together with the emissions finishing treatment, inner-engine further developments are focused on for the reduction of consumption and raw exhaust gas. In conjunction with the support of the FVV (German Research Association for Combustion Engines), AFT Atlas Fahrzeugtechnik GmbH has developed the open engine control unit PROtroniC trademark especially for the research and development of combustion engines. Through the open and flexible structure of the control system, engines can be initialised on stationary test-bench applications in extremely short time periods. The implementation of user-specific functions means new ideas can be developed and tested directly. A series production vehicle was transformed into a test vehicle for the further development of vehicle-relevant functions, such as physically based dynamic functions, engine idle controller and the integration in the control unit topology. As this vehicle is now driven with the PROtroniC trademark, further algorithms can now be tried and tested directly in the vehicle. Combustion-relevant variables are often of great importance in the development phase. If the combustion is to be controlled on the basis of such variables, the conversion mostly results in highly complex system superstructures. A combustion computation has therefore been integrated in the PROtroniC trademark, which calculates the appropriate parameters in real-time and provides them in the control unit for further control tasks. (orig.)

  10. Linking genes to microbial growth kinetics: an integrated biochemical systems engineering approach.

    Science.gov (United States)

    Koutinas, Michalis; Kiparissides, Alexandros; Silva-Rocha, Rafael; Lam, Ming-Chi; Martins Dos Santos, Vitor A P; de Lorenzo, Victor; Pistikopoulos, Efstratios N; Mantalaris, Athanasios

    2011-07-01

    The majority of models describing the kinetic properties of a microorganism for a given substrate are unstructured and empirical. They are formulated in this manner so that the complex mechanism of cell growth is simplified. Herein, a novel approach for modelling microbial growth kinetics is proposed, linking biomass growth and substrate consumption rates to the gene regulatory programmes that control these processes. A dynamic model of the TOL (pWW0) plasmid of Pseudomonas putida mt-2 has been developed, describing the molecular interactions that lead to the transcription of the upper and meta operons, known to produce the enzymes for the oxidative catabolism of m-xylene. The genetic circuit model was combined with a growth kinetic model decoupling biomass growth and substrate consumption rates, which are expressed as independent functions of the rate-limiting enzymes produced by the operons. Estimation of model parameters and validation of the model's predictive capability were successfully performed in batch cultures of mt-2 fed with different concentrations of m-xylene, as confirmed by relative mRNA concentration measurements of the promoters encoded in TOL. The growth formation and substrate utilisation patterns could not be accurately described by traditional Monod-type models for a wide range of conditions, demonstrating the critical importance of gene regulation for the development of advanced models closely predicting complex bioprocesses. In contrast, the proposed strategy, which utilises quantitative information pertaining to upstream molecular events that control the production of rate-limiting enzymes, predicts the catabolism of a substrate and biomass formation and could be of central importance for the design of optimal bioprocesses. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. A DMAIC approach for process capability improvement an engine crankshaft manufacturing process

    OpenAIRE

    Sharma, G.V.S.S.; Rao, P. Srinivasa

    2014-01-01

    The define-measure-analyze-improve-control (DMAIC) approach is a five-strata approach, namely DMAIC. This approach is the scientific approach for reducing the deviations and improving the capability levels of the manufacturing processes. The present work elaborates on DMAIC approach applied in reducing the process variations of the stub-end-hole boring operation of the manufacture of crankshaft. This statistical process control study starts with selection of the critical-to-quality (CTQ) char...

  12. Approach for energy saving and pollution reducing by fueling diesel engines with emulsified biosolution/ biodiesel/diesel blends.

    Science.gov (United States)

    Lin, Yuan-Chung; Lee, Wen-Jhy; Chao, How-Ran; Wang, Shu-Li; Tsou, Tsui-Chun; Chang-Chien, Guo-Ping; Tsai, Perng-Jy

    2008-05-15

    The developments of both biodiesel and emulsified diesel are being driven by the need for reducing emissions from diesel engines and saving energy. Artificial chemical additives are also being used in diesel engines for increasing their combustion efficiencies. But the effects associated with the use of emulsified additive/biodiesel/diesel blends in diesel engines have never been assessed. In this research, the premium diesel fuel (PDF) was used as the reference fuel. A soy-biodiesel was selected as the test biodiesel. A biosolution made of 96.5 wt % natural organic enzyme-7F (NOE-7F) and 3.5 wt % water (NOE-7F water) was used as the fuel additive. By adding additional 1 vol % of surfactant into the fuel blend, a nanotechnology was used to form emulsified biosolution/soy-biodiesel/PDF blends for fueling the diesel engine. We found that the emulsified biosolution/soy-biodiesel/PDF blends did not separate after being kept motionless for 30 days. The above stability suggests that the above combinations are suitable for diesel engines as alternative fuels. Particularly, we found that the emulsified biosolution/soy-biodiesel/PDF blends did have the advantage in saving energy and reducing the emissions of both particulate matters (PM) and polycyclic aromatic hydrocarbons (PAHs) from diesel engines as compared with PDF, soy-biodiesel/PDF blends, and emulsified soy-biodiesel/ PDF blends. The results obtained from this study will provide useful approaches for reducing the petroleum reliance, pollution, and global warming. However, it should be noted that NO(x) emissions were not measured in the present study which warrants the need for future investigation.

  13. Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications.

    Science.gov (United States)

    Bober, Josef R; Beisel, Chase L; Nair, Nikhil U

    2018-03-12

    An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights have generated significant interest in engineering indigenous microbiota community members and nonresident probiotic bacteria as biotic diagnostics and therapeutics that can probe and improve human health. In this review, we discuss recent advances in synthetic biology to engineer commensal and probiotic lactic acid bacteria, bifidobacteria, and Bacteroides for these purposes, and we provide our perspective on the future potential of these technologies. 277 Expected final online publication date for the Annual Review of Biomedical Engineering Volume 20 is June 4, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

  14. Biotechnology and synthetic biology approaches for metabolic engineering of bioenergy crops.

    Science.gov (United States)

    Shih, Patrick M; Liang, Yan; Loqué, Dominique

    2016-07-01

    The Green Revolution has fuelled an exponential growth in human population since the mid-20th century. Due to population growth, food and energy demands will soon surpass supply capabilities. To overcome these impending problems, significant improvements in genetic engineering will be needed to complement breeding efforts in order to accelerate the improvement of agronomical traits. The new field of plant synthetic biology has emerged in recent years and is expected to support rapid, precise, and robust engineering of plants. In this review, we present recent advances made in the field of plant synthetic biology, specifically in genome editing, transgene expression regulation, and bioenergy crop engineering, with a focus on traits related to lignocellulose, oil, and soluble sugars. Ultimately, progress and innovation in these fields may facilitate the development of beneficial traits in crop plants to meet society's bioenergy needs. © 2016 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.

  15. Bringing simulation to engineers in the field: a Web 2.0 approach.

    Science.gov (United States)

    Haines, Robert; Khan, Kashif; Brooke, John

    2009-07-13

    Field engineers working on water distribution systems have to implement day-to-day operational decisions. Since pipe networks are highly interconnected, the effects of such decisions are correlated with hydraulic and water quality conditions elsewhere in the network. This makes the provision of predictive decision support tools (DSTs) for field engineers critical to optimizing the engineering work on the network. We describe how we created DSTs to run on lightweight mobile devices by using the Web 2.0 technique known as Software as a Service. We designed our system following the architectural style of representational state transfer. The system not only displays static geographical information system data for pipe networks, but also dynamic information and prediction of network state, by invoking and displaying the results of simulations running on more powerful remote resources.

  16. A Project-based Learning curricular approach in a Production Engineering Program

    Directory of Open Access Journals (Sweden)

    Simone Borges Simão Monteiro

    2017-09-01

    Full Text Available Abstract The Industrial Engineering undergraduate program offered at the University of Brasília was structured on Project Based Learning (PBL methodology. This innovative educational proposal allows the students to deploy their technical competencies through real problem solving situations. The methodology also stimulates the development of the students’ soft skills, by exposing them to a challenging environment. At the end of each project, the results are presented to an external agent, and are subsequently implemented. The objective of this paper is to present the evolution of the PSP courses, which adopt as guidelines both the PMBOK project management framework, as well as content from specific technical courses related to the project’s subject. One other relevant aspect of the PSP courses is their involvement of both undergraduate and graduate students from different Engineering areas, such as Industrial, Mechanical and Civil Engineering, which serves to foster a more holistic and integrated problem-solving skillset.

  17. Equivalent electrical network model approach applied to a double acting low temperature differential Stirling engine

    International Nuclear Information System (INIS)

    Formosa, Fabien; Badel, Adrien; Lottin, Jacques

    2014-01-01

    Highlights: • An equivalent electrical network modeling of Stirling engine is proposed. • This model is applied to a membrane low temperate double acting Stirling engine. • The operating conditions (self-startup and steady state behavior) are defined. • An experimental engine is presented and tested. • The model is validated against experimental results. - Abstract: This work presents a network model to simulate the periodic behavior of a double acting free piston type Stirling engine. Each component of the engine is considered independently and its equivalent electrical circuit derived. When assembled in a global electrical network, a global model of the engine is established. Its steady behavior can be obtained by the analysis of the transfer function for one phase from the piston to the expansion chamber. It is then possible to simulate the dynamic (steady state stroke and operation frequency) as well as the thermodynamic performances (output power and efficiency) for given mean pressure, heat source and heat sink temperatures. The motion amplitude especially can be determined by the spring-mass properties of the moving parts and the main nonlinear effects which are taken into account in the model. The thermodynamic features of the model have then been validated using the classical isothermal Schmidt analysis for a given stroke. A three-phase low temperature differential double acting free membrane architecture has been built and tested. The experimental results are compared with the model and a satisfactory agreement is obtained. The stroke and operating frequency are predicted with less than 2% error whereas the output power discrepancy is of about 30%. Finally, some optimization routes are suggested to improve the design and maximize the performances aiming at waste heat recovery applications

  18. Gasoline compression ignition approach to efficient, clean and affordable future engines

    KAUST Repository

    Kalghatgi, Gautam

    2017-04-03

    The worldwide demand for transport fuels will increase significantly but will still be met substantially (a share of around 90%) from petroleum-based fuels. This increase in demand will be significantly skewed towards commercial vehicles and hence towards diesel and jet fuels, leading to a probable surplus of lighter low-octane fuels. Current diesel engines are efficient but expensive and complicated because they try to reduce the nitrogen oxide and soot emissions simultaneously while using conventional diesel fuels which ignite very easily. Gasoline compression ignition engines can be run on gasoline-like fuels with a long ignition delay to make low-nitrogen-oxide low-soot combustion very much easier. Moreover, the research octane number of the optimum fuel for gasoline compression ignition engines is likely to be around 70 and hence the surplus low-octane components could be used without much further processing. Also, the final boiling point can be higher than those of current gasolines. The potential advantages of gasoline compression ignition engines are as follows. First, the engine is at least as efficient and clean as current diesel engines but is less complicated and hence could be cheaper (lower injection pressure and after-treatment focus on control of carbon monoxide and hydrocarbon emissions rather than on soot and nitrogen oxide emissions). Second, the optimum fuel requires less processing and hence would be easier to make in comparison with current gasoline or diesel fuel and will have a lower greenhouse-gas footprint. Third, it provides a path to mitigate the global demand imbalance between heavier fuels and lighter fuels that is otherwise projected and improve the sustainability of refineries. The concept has been well demonstrated in research engines but development work is needed to make it feasible on practical vehicles, e.g. on cold start, adequate control of exhaust carbon monoxide and hydrocarbons and control of noise at medium to high loads

  19. Review of the Space Mapping Approach to Engineering Optimization and Modeling

    DEFF Research Database (Denmark)

    Bakr, M. H.; Bandler, J. W.; Madsen, Kaj

    2000-01-01

    We review the Space Mapping (SM) concept and its applications in engineering optimization and modeling. The aim of SM is to avoid computationally expensive calculations encountered in simulating an engineering system. The existence of less accurate but fast physically-based models is exploited. SM...... drives the optimization iterates of the time-intensive model using the fast model. Several algorithms have been developed for SM optimization, including the original SM algorithm, Aggressive Space Mapping (ASM), Trust Region Aggressive Space Mapping (TRASM) and Hybrid Aggressive Space Mapping (HASM...

  20. Fuel Continuous Mixer ? an Approach Solution to Use Straight Vegetable Oil for Marine Diesel Engines

    OpenAIRE

    Đặng Van Uy; Tran The Nam

    2018-01-01

    The vegetable oil is well known as green fuel for diesel engines due to its low sunphur content and renewable stock. However, there are some problems raising when vegetable oil is used as fuel for diesel engines such as highly effected by cold weather, lower general efficiency, separation in layer if mixed with diesel oil and so on. To overcome that disadvantiges, the authors propose a new idea that to use a continuous fuel mixer to blend vegetable oil with diesel oil to make so called a mixe...

  1. BUSINESS MANAGEMENT THEORY DEVELOPED ON THE BASIS OF SYSTEM APPROACH AND BUSINESS ENGINEERING TOOLS

    Directory of Open Access Journals (Sweden)

    N. I. Strich

    2011-01-01

    Full Text Available Management should be carried out with due account of the system theory and using tools and opportunities offered by such modern management components as business engineering and reengineering. Main points of this theory are given along with detailed determination of business engineering and reengineering particularly efficient while determining measures needed to reorganize an enterprise (or a group of enterprises through updating its organizational structure as well as economic, personnel or other system. Out-sourcing also described in detail is considered as modern enterprise management system’s most efficient instrument.

  2. Applying Rock Engineering Systems (RES approach to Evaluate and Classify the Coal Spontaneous Combustion Potential in Eastern Alborz Coal Mines

    Directory of Open Access Journals (Sweden)

    Amir Saffari

    2013-12-01

    Full Text Available Subject analysis of the potential of spontaneous combustion in coal layers with analytical and numerical methods has been always considered as a difficult task because of the complexity of the coal behavior and the number of factors influencing it. Empirical methods, due to accounting for certain and specific factors, have not accuracy and efficiency for all positions. The Rock Engineering Systems (RES approach as a systematic method for analyzing and classifying is proposed in engineering projects. The present study is concerned with employing the RES approach to categorize coal spontaneous combustion in coal regions. Using this approach, the interaction of parameters affecting each other in an equal scale on the coal spontaneous combustion was evaluated. The Intrinsic, geological and mining characteristics of coal seams were studied in order to identifying important parameters. Then, the main stages of implementation of the RES method i.e. interaction matrix formation, coding matrix and forming a list category were performed. Later, an index of Coal Spontaneous Combustion Potential (CSCPi was determined to format the mathematical equation. Then, the obtained data related to the intrinsic, geological and mining, and special index were calculated for each layer in the case study (Pashkalat coal region, Iran. So, the study offers a perfect and comprehensive classification of the layers. Finally, by using the event of spontaneous combustion occurred in Pashkalat coal region, an initial validation for this systematic approach in the study area was conducted, which suggested relatively good concordance in Pashkalat coal region.

  3. The Road Not Taken: Frank Aydelotte and the Thought Approach to Engineering Writing.

    Science.gov (United States)

    Moran, Michael G.

    1993-01-01

    Describes the development of, and examines the assumptions behind, Frank Aydelotte's 1917 theory and pedagogy of technical writing, called the "thought movement," in which engineering students were required to think and write about issues important to their education and future careers. (SR)

  4. A Multidisciplinary PBL Approach for Teaching Industrial Informatics and Robotics in Engineering

    Science.gov (United States)

    Calvo, Isidro; Cabanes, Itziar; Quesada, Jeronimo; Barambones, Oscar

    2018-01-01

    This paper describes the design of an industrial informatics course, following the project-based learning methodology, and reports the experience of four academic years (from 2012-13 to 2015-16). Industrial Informatics is a compulsory course taught in the third year of the B.Sc. degree in industrial electronics and automation engineering at the…

  5. SysML for systems engineering a model-based approach

    CERN Document Server

    Holt, Jon

    2013-01-01

    This new edition of this popular text has been fully updated to reflect SysML 1.3, the latest version of the standard, and the discussion has been extended to show the power of SysML as a tool for systems engineering in an MBSE context.

  6. Critical Thinking Disposition: The Effects of Infusion Approach in Engineering Drawing

    Science.gov (United States)

    Darby, Norazlinda Mohd; Rashid, Abdullah Mat

    2017-01-01

    Critical Thinking Disposition is known as an important factor that drives a student to use Higher Order Thinking Skills (HOTS) in order to solve engineering drawing problems. Infusing them while teaching the subject may enhance students' disposition and higher order thinking skills. However, no research has been done in critical thinking…

  7. Application of the Total Quality Management Approach Principles and the ISO 9000 Standards in Engineering Education.

    Science.gov (United States)

    Waks, Shlomo; Frank, Moti

    1999-01-01

    Discusses the applicability of the definition, principles, and underlying strategies of total quality management (TQM) for engineering education. Describes several tools and methods for the implementation of TQM and its suitability for a variety of school activities. Presents a TQM course outline combining lectures, discussions, suggested…

  8. Approaches to evaluating weathering effects on release of engineered nanomaterials from solid matrices

    Science.gov (United States)

    Increased production and use of engineered nanomaterials (ENMs) over the past decade has increased the potential for the transport and release of these materials into the environment. Here we present results of two separate studies designed to simulate the effects of weathering o...

  9. The romanian educational system in nuclear engineering field - experience and new approaches

    International Nuclear Information System (INIS)

    Dragusin, O.; Burghelea, A.

    2000-01-01

    In this paper we would like to present the actual status of the education in the nuclear engineering field at 'POLITEHNICA' University Bucharest, Nuclear Power Plant Department, and also the efforts of integration of the educational system of Romania into the international system and the development of new concepts concerning the education of the new specialists generation. (authors)

  10. On the electrical breakdown of gaseous dielectrics-an engineering approach

    DEFF Research Database (Denmark)

    Pedersen, Aage

    1989-01-01

    from breakdown voltage measurements in a uniform field, i.e. from Paschen curve data. No specific data are required for the ionizing coefficients of the gas. The advantage, from an engineering point of view, is that it is much easier to perform reliable Paschen curve measurements than it is to measure...

  11. Towards a Sustainable Approach to Nanotechnology by Integrating Life Cycle Assessment into the Undergraduate Engineering Curriculum

    Science.gov (United States)

    Kopelevich, Dmitry I.; Ziegler, Kirk J.; Lindner, Angela S.; Bonzongo, Jean-Claude J.

    2012-01-01

    Because rapid growth of nanotechnology is expected to lead to intentional and non-intentional releases, future engineers will need to minimize negative environmental and health impacts of nanomaterials. We developed two upper-level undergraduate courses centered on life-cycle assessment of nanomaterials. The first part of the course sequence…

  12. Establishing the Overall Service Quality of Engineering Education: Fuzzy Logic Approach

    Science.gov (United States)

    Shekhar, N. Chandra; Venkatasubbaiah, K.; Kandukuria, N. R.

    2012-01-01

    Measuring overall service quality (OSQ) is gaining prominence in higher education due to the increased competition among engineering education institutions (EEIs) and growing awareness about value for money among the public. Determination of OSQ on certain institutional aspects is done by various agencies throughout the world. Each system uses a…

  13. The Chemical Engineer's Toolbox: A Glass Box Approach to Numerical Problem Solving

    Science.gov (United States)

    Coronell, Daniel G.; Hariri, M. Hossein

    2009-01-01

    Computer programming in undergraduate engineering education all too often begins and ends with the freshman programming course. Improvements in computer technology and curriculum revision have improved this situation, but often at the expense of the students' learning due to the use of commercial "black box" software. This paper describes the…

  14. A Systems Thinking Approach to Engineering Challenges of Military Systems-of-Systems

    Science.gov (United States)

    2016-09-01

    particular in aspects of cooperation, interoperability, joint effects, emergent behaviours and uncertainties. SoS development state management is...processes. Inadequate understanding of SoS problems and inability to manage complexity encountered in planning, development and operation of...Systems (SoS) is broadly acknowledged as an engineering and management challenge for defence organisations, in particular in pursuing joint force

  15. Avoid, Control, Succumb, or Balance: Engineering Students' Approaches to a Wicked Sustainability Problem

    Science.gov (United States)

    Lönngren, Johanna; Ingerman, Åke; Svanström, Magdalena

    2017-01-01

    Wicked sustainability problems (WSPs) are an important and particularly challenging type of problem. Science and engineering education can play an important role in preparing students to deal with such problems, but current educational practice may not adequately prepare students to do so. We address this gap by providing insights related to…

  16. Prognostic and health management for engineering systems: a review of the data-driven approach and algorithms

    Directory of Open Access Journals (Sweden)

    Thamo Sutharssan

    2015-07-01

    Full Text Available Prognostics and health management (PHM has become an important component of many engineering systems and products, where algorithms are used to detect anomalies, diagnose faults and predict remaining useful lifetime (RUL. PHM can provide many advantages to users and maintainers. Although primary goals are to ensure the safety, provide state of the health and estimate RUL of the components and systems, there are also financial benefits such as operational and maintenance cost reductions and extended lifetime. This study aims at reviewing the current status of algorithms and methods used to underpin different existing PHM approaches. The focus is on providing a structured and comprehensive classification of the existing state-of-the-art PHM approaches, data-driven approaches and algorithms.

  17. Engine dynamic analysis with general nonlinear finite-element codes. I Overall approach and development of bearing damper element

    Science.gov (United States)

    Adams, M. L.; Padovan, J.; Fertis, D. G.

    1981-01-01

    NASA-sponsored research on engine dynamic simulation using general finite element nonlinear time transient computer codes available on the open market is reviewed. The approach taken was to develop software packages to model engine components which are not typically found on dynamical structures and are therefore not already computer codes. The software package developed for squeeze-film bearing dampers is outlined, and the results of a parametric study of damper pressure for a variety of specified circular orbits are presented for both long-bearing and short-bearing solutions. The data from a four-degree-of-freedom rotor-damper-stator model under conditions of small rotor unbalance through large rotor unbalance are also given.

  18. Can Creativity Predict Cognitive Reserve?

    Science.gov (United States)

    Palmiero, Massimiliano; Di Giacomo, Dina; Passafiume, Domenico

    2016-01-01

    Cognitive reserve relies on the ability to effectively cope with aging and brain damage by using alternate processes to approach tasks when standard approaches are no longer available. In this study, the issue if creativity can predict cognitive reserve has been explored. Forty participants (mean age: 61 years) filled out: the Cognitive Reserve…

  19. COLLABORATIVE NEGOTIATIONS A SUCCESSFUL APPROACH FOR NEGOTIATING COMPLIANCE MILESTONES FOR THE TRANSITION OF THE PLUTONIUM FINISHING PLANT (PFP), HANFORD NUCLEAR RESERVATION, AND HANFORD, WASHINGTON

    International Nuclear Information System (INIS)

    Hebdon, J.; Yerxa, J.; Romine, L.; Hopkins, AM; Piippo, R.; Cusack, L.; Bond, R.; Wang, Oliver; Willis, D.

    2003-01-01

    The Hanford Nuclear Reservation is a former U. S. Department of Energy Defense Production Site. The site is currently listed on the National Priorities List of the Comprehensive Environmental Response Compensation and Liability Act of 1980 (CERCLA) and is undergoing cleanup and environmental restoration. The PFP is a former Plutonium metal production facility. The operating mission of the PFP ended with a DOE Headquarters shutdown letter in October of 1996. Generally, the receipt of a shutdown letter initiates the start of Transition (as the first step of Decommissioning) of a facility. The Hanford site is subject to the Hanford Federal Facilities Compliance Act and Consent Order (HFFCCO), an order on consent signed by the DOE, the U. S. Environmental Protection Agency, (EPA) and the Washington Department of Ecology (WDOE). Under the HFFCCO, negotiations for transition milestones begin within six months after the issuance of a shutdown order. In the case of the PFP, the Nuclear Materials disposition and stabilization activities, a DOE responsibility, were necessary as precursor activities to Transition. This situation precipitated a crisis in the negotiations between the agencies, and formal negotiations initiated in 1997 ended in failure. The negotiations reached impasse on several key regulatory and operational issues. The 1997 negotiation was characterized by a strongly positional style. DOE and the regulatory personnel took hard lines early in the negotiations and were unable to move to resolution of key issues after a year and a half. This resulted in unhappy stakeholders, poor publicity and work delays as well as wounded relationships between DOE and the regulatory community. In the 2000-2001 PFP negotiations, a completely different approach was suggested and eventually initiated: Collaborative Negotiations. The collaborative negotiation style resulted in agreement between the agencies on all key issues within 6 months of initiation. All parties were very

  20. COLLABORATIVE NEGOTIATIONS A SUCCESSFUL APPROACH FOR NEGOTIATING COMPLIANCE MILESTONES FOR THE TRANSITION OF THE PLUTONIUM FINISHING PLANT (PFP), HANFORD NUCLEAR RESERVATION, AND HANFORD, WASHINGTON

    Energy Technology Data Exchange (ETDEWEB)

    Hebdon, J.; Yerxa, J.; Romine, L.; Hopkins, AM; Piippo, R.; Cusack, L.; Bond, R.; Wang, Oliver; Willis, D.

    2003-02-27

    The Hanford Nuclear Reservation is a former U. S. Department of Energy Defense Production Site. The site is currently listed on the National Priorities List of the Comprehensive Environmental Response Compensation and Liability Act of 1980 (CERCLA) and is undergoing cleanup and environmental restoration. The PFP is a former Plutonium metal production facility. The operating mission of the PFP ended with a DOE Headquarters shutdown letter in October of 1996. Generally, the receipt of a shutdown letter initiates the start of Transition (as the first step of Decommissioning) of a facility. The Hanford site is subject to the Hanford Federal Facilities Compliance Act and Consent Order (HFFCCO), an order on consent signed by the DOE, the U. S. Environmental Protection Agency, (EPA) and the Washington Department of Ecology (WDOE). Under the HFFCCO, negotiations for transition milestones begin within six months after the issuance of a shutdown order. In the case of the PFP, the Nuclear Materials disposition and stabilization activities, a DOE responsibility, were necessary as precursor activities to Transition. This situation precipitated a crisis in the negotiations between the agencies, and formal negotiations initiated in 1997 ended in failure. The negotiations reached impasse on several key regulatory and operational issues. The 1997 negotiation was characterized by a strongly positional style. DOE and the regulatory personnel took hard lines early in the negotiations and were unable to move to resolution of key issues after a year and a half. This resulted in unhappy stakeholders, poor publicity and work delays as well as wounded relationships between DOE and the regulatory community. In the 2000-2001 PFP negotiations, a completely different approach was suggested and eventually initiated: Collaborative Negotiations. The collaborative negotiation style resulted in agreement between the agencies on all key issues within 6 months of initiation. All parties were very

  1. A Pragmatic Approach to Ethical Decision-Making in Engineering Practice: Characteristics, Evaluation Criteria, and Implications for Instruction and Assessment.

    Science.gov (United States)

    Zhu, Qin; Jesiek, Brent K

    2017-06-01

    This paper begins by reviewing dominant themes in current teaching of professional ethics in engineering education. In contrast to more traditional approaches that simulate ethical practice by using ethical theories to reason through micro-level ethical dilemmas, this paper proposes a pragmatic approach to ethics that places more emphasis on the practical plausibility of ethical decision-making. In addition to the quality of ethical justification, the value of a moral action also depends on its effectiveness in solving an ethical dilemma, cultivating healthy working relationships, negotiating existing organizational cultures, and achieving contextual plausibility in everyday professional practice. This paper uses a cross-cultural ethics scenario to further elaborate how a pragmatic approach can help us rethink ethical reasoning, as well as ethics instruction and assessment. This paper is expected to be of interest to educators eager to improve the ability of engineers and other professional students to effectively and appropriately deal with the kinds of everyday ethical issues they will likely face in their careers.

  2. Philosophical Approach to Engineering Education Under the Introduction of the Smart Grid Concept in Russia

    Directory of Open Access Journals (Sweden)

    Makienko Marina A.

    2015-01-01

    Full Text Available The development of power industry in the world today is driven by two main trends: the search for renewable energy sources and their use and the energy efficiency which require the development of smart grids. This paper brings up the issue of staff training for professional development of the Smart Grid technology and for use of its elements by customers in households. The problem of consumer readiness for the use of smart meters was studied. It was revealed that the considerable part of the respondents was not familiar with the definition of Smart Grid. That required the development of communication skills by energy engineering students and their social activity as well. The reasons mentioned make actual the following elements of engineering education: social responsibility, stress resistance, ability to forecast the future.

  3. Evaluation of FCS self and peer-assessment approach based on Cooperative and Engineering Design learning.

    Science.gov (United States)

    Cvetkovic, Dean

    2013-01-01

    The Cooperative Learning in Engineering Design curriculum can be enhanced with structured and timely self and peer assessment teaching methodologies which can easily be applied to any Biomedical Engineering curriculum. A study was designed and implemented to evaluate the effectiveness of this structured and timely self and peer assessment on student team-based projects. In comparing the 'peer-blind' and 'face-to-face' Fair Contribution Scoring (FCS) methods, both had advantages and disadvantages. The 'peer-blind' self and peer assessment method would cause high discrepancy between self and team ratings. But the 'face-to-face' method on the other hand did not have the discrepancy issue and had actually proved to be a more accurate and effective, indicating team cohesiveness and good cooperative learning.

  4. Interleukin 7-engineered stromal cells: a new approach for hastening naive T cell recruitment.

    Science.gov (United States)

    Di Ianni, Mauro; Del Papa, Beatrice; De Ioanni, Maria; Terenzi, Adelmo; Sportoletti, Paolo; Moretti, Lorenzo; Falzetti, Franca; Gaozza, Eugenia; Zei, Tiziana; Spinozzi, Fabrizio; Bagnis, Claude; Mannoni, Patrice; Bonifacio, Elisabetta; Falini, Brunangelo; Martelli, Massimo F; Tabilio, Antonio

    2005-06-01

    In this study we determined whether human stromal cells could be engineered with a retroviral vector carrying the interleukin 7 (IL-7) gene and investigated the effects on T cells in vitro and in vivo in a murine model. Transduced mesenchymal cells strongly express CD90 (98.15%), CD105 (87.6%), and STRO-1 (86.7%). IL-7 production was 16.37 (+/-2 SD) pg/ml, which remained stable for 60 days. In vitro-immunoselected naive T cells maintained the CD45RA+ CD45RO- naive phenotype (4.2 times more than controls) after 7 days of culture with IL-7-engineered stromal cells. The apoptosis rate (4.7%) of the naive T cells cultured with transduced stromal cells overlapped with that of freshly isolated cells. Immunohistological analysis detected stromal cells in bone marrow, spleen, and thymus. Cotransplantation of IL-7-engineered stromal cells with CD34+ cells improved engraftment in terms of CD45+ cells and significantly increased the CD3+ cell count in peripheral blood, bone marrow, and spleen. These data demonstrate the following: (1) human stromal cells can be transduced, generating a normal layer; (2) transduced stromal cells in vitro maintain the naive T cell phenotype; and (3) IL-7-transduced stromal cells in vivo home to lymphoid organs and produce sufficient IL-7 in loco, supporting T cell development in a cotransplantation model. Because of their efficient cytokine production and homing, IL-7-engineered stromal cells might be an ideal vehicle to hasten immunological reconstitution in T cell-depleted hosts.

  5. A Problem-Solving Approach to Teaching Creativity for Engineering and Other Disciplines

    Directory of Open Access Journals (Sweden)

    Chelsey Bradford

    2014-08-01

    Full Text Available Creativity is an integral part in the careers of every professional, including artists, actors, as well as businessmen and engineers. Engineers, the focus of this effort, are traditionally considered to be systematic thinkers and implementers of constrained procedures and algorithms. In order to challenge this perception, ECE490DI is a class designed to show engineering students that their majors and future careers will not only use creativity, but be fully immersed in it. Once the students realize this fact, the next step is to help them discover their own creativity skills and show them that creativity, like other talents, can be nurtured and strengthened through repetitive use. To accomplish these goals, students in ECE490DI take a class trip to renowned theme parks in Orlando, FL, where they attend multiple workshops in the areas of leadership, teamwork, and creativity. The workshops allow students to exercise their leadership, teamwork, and creativity and show them several tools to expand and further improve their abilities in those areas. Students are also given the chance to meet and interact with theme parks' engineers, also known as "Imagineers," to see the practical applications of creativity in a hands-on creative work environment. While the objectives of ECE490DI were successfully met in previous semesters, the class was redesigned to have a broader scope and a multidisciplinary nature. The multidisciplinary version of the class builds on the assessment results of the previous offerings as well as feedback from participating students, faculty members, and theme parks staff members. The new version of the class includes more meetings throughout the semester to further reinforce the ideas and concepts from the workshops.

  6. A modern approach to storing of 3D geometry of objects in machine engineering industry

    Science.gov (United States)

    Sokolova, E. A.; Aslanov, G. A.; Sokolov, A. A.

    2017-02-01

    3D graphics is a kind of computer graphics which has absorbed a lot from the vector and raster computer graphics. It is used in interior design projects, architectural projects, advertising, while creating educational computer programs, movies, visual images of parts and products in engineering, etc. 3D computer graphics allows one to create 3D scenes along with simulation of light conditions and setting up standpoints.

  7. Using a Formal Approach for Reverse Engineering and Design Recovery to Support Software Reuse

    Science.gov (United States)

    Gannod, Gerald C.

    2002-01-01

    This document describes 3rd year accomplishments and summarizes overall project accomplishments. Included as attachments are all published papers from year three. Note that the budget for this project was discontinued after year two, but that a residual budget from year two allowed minimal continuance into year three. Accomplishments include initial investigations into log-file based reverse engineering, service-based software reuse, and a source to XML generator.

  8. A Comprehensive Environmental Assessment Approach to Making Informed Decisions about Engineered Nanoparticles

    Science.gov (United States)

    2011-05-01

    BUILDING STRONG® ERDC CEA Case Study: Engineered Aluminum Nanoparticles 5 m. BUILDING STRONG® •Lack of mature industries •Data lacking or evolving...Storage •Use of nano- aluminum still in the R&D phase •Stored under inert atmosphere •Aggregates are stored at the facility (still have research...bioaccumulation 3.Internal • Cell damage in several in vitro studies using internal organ cultures • Neurotoxicity (blood brain barrier disruption) and

  9. A Systems Engineering Approach to Integrated Structural Health Monitoring for Aging Aircraft

    Science.gov (United States)

    2006-03-23

    hours. The re- sults of these seven runs are presented in Table 4.5. These baseline runs helped to characterize the baseline behavior such that it could...due to crack growth, corrosion, fatigue stress, load stress, etc. Flight Profile - refers to the severity or level of aggresiveness with wich the...Mechanical Behavior of Materials: Engineering Methods for Deformation, Fracture, and Fatigue. Printice Hall, 1993. 1st ed. 29. Eisner, Howard. Essentials

  10. Combined analytical and numerical approaches in Dynamic Stability analyses of engineering system

    Czech Academy of Sciences Publication Activity Database

    Náprstek, Jiří

    2015-01-01

    Roč. 338, March (2015), s. 2-41 ISSN 0022-460X R&D Projects: GA ČR(CZ) GC13-34405J Institutional support: RVO:68378297 Keywords : strongly nonlinear oscillators * moment Lyapunov exponents * predator-prey system * differential-equations Subject RIV: JM - Building Engineering Impact factor: 2.107, year: 2015 http://www.sciencedirect.com/science/article/pii/S0022460X14005355

  11. Genetic engineering approach to develop next-generation reagents for endotoxin quantification

    OpenAIRE

    Mizumura, Hikaru; Ogura, Norihiko; Aketagawa, Jun; Aizawa, Maki; Kobayashi, Yuki; Kawabata, Shun-ichiro; Oda, Toshio

    2016-01-01

    The bacterial endotoxin test, which uses amebocyte lysate reagents of horseshoe crab origin, is a sensitive, reproducible and simple assay to measure endotoxin concentration. To develop sustainable raw materials for lysate reagents that do not require horseshoe crabs, three recombinant protease zymogens (factor C, derived from mammalian cells; factor B; and the proclotting enzyme derived from insect cells) were prepared using a genetic engineering technique. Recombinant cascade reagents (RCRs...

  12. Phase-Change Memory Materials by Design: A Strain Engineering Approach.

    Science.gov (United States)

    Zhou, Xilin; Kalikka, Janne; Ji, Xinglong; Wu, Liangcai; Song, Zhitang; Simpson, Robert E

    2016-04-20

    Van der Waals heterostructure superlattices of Sb2 Te1 and GeTe are strain-engineered to promote switchable atomic disordering, which is confined to the GeTe layer. Careful control of the strain in the structures presents a new degree of freedom to design the properties of functional superlattice structures for data storage and photonics applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Systems Engineering Approach to Develop Guidance, Navigation and Control Algorithms for Unmanned Ground Vehicle

    Science.gov (United States)

    2016-09-01

    conducted further illustrated the computational and engineering strain that one could face with operating an unmanned system in a tropical environment...direction of the Earth’s magnetic field to determine the geographic poles which is akin to a conventional compass. The use of magnetoresistive alloys...however cautioned on the necessary trade- offs that must be properly studied on as the addition of sensors would not only add a strain to the power

  14. A qualitative approach to risk assessment and control in engineered nanoparticles occupational exposure

    OpenAIRE

    Silva, Francisco António Coelho e

    2016-01-01

    Doctoral Dissertation for PhD degree in Industrial and Systems Engineering The existing research effort and common use of nanomaterials, that are an opportunity for economic growth, pose health and safety problems. The research on the nanoparticles health effects performed during the last decade shows the possible harmfulness of several nanoparticles, including those already present in everyday use products, thus worker’s health and safety are critical to the development of nan...

  15. TOPSIS Multi-Criteria Decision Modeling Approach for Biolubricant Selection for Two-Stroke Petrol Engines

    Directory of Open Access Journals (Sweden)

    Masoud Dehghani Soufi

    2015-12-01

    Full Text Available Exhaust pollutants from two-stroke petrol engines are a problem for the environment. Biolubricants are a new generation of renewable and eco-friendly vegetable-based lubricants, which have attracted a lot of attention in recent years. In this paper, the applicability of the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS method to support the process of building the scoring system for selecting an appropriate two-stroke lubricant has been analyzed. For this purpose, biolubricants (TMP-triesters based on castor oil, palm oil, and waste cooking oil were produced and then utilized in a 200 cc two-stroke gasoline engine to investigate their effects on its performance and exhaust emissions. The results obtained from the use of the entropy technique in the TOPSIS algorithm showed that palm oil-based lubricant took up the greatest distance from the Negative Ideal Solution (NIS and was selected as the most optimal lubricant for these types of engines.

  16. General approach for engineering small-molecule-binding DNA split aptamers.

    Science.gov (United States)

    Kent, Alexandra D; Spiropulos, Nicholas G; Heemstra, Jennifer M

    2013-10-15

    Here we report a general method for engineering three-way junction DNA aptamers into split aptamers. Split aptamers show significant potential for use as recognition elements in biosensing applications, but reliable methods for generating these sequences are currently lacking. We hypothesize that the three-way junction is a "privileged architecture" for the elaboration of aptamers into split aptamers, as it provides two potential splitting sites that are distal from the target binding pocket. We propose a general method for split aptamer engineering that involves removing one loop region, then systematically modifying the number of base pairs in the remaining stem regions in order to achieve selective assembly only in the presence of the target small molecule. We screen putative split aptamer sequence pairs using split aptamer proximity ligation (StAPL) technology developed by our laboratory, but we validate that the results obtained using StAPL translate directly to systems in which the aptamer fragments are assembling noncovalently. We introduce four new split aptamer sequences, which triples the number of small-molecule-binding DNA split aptamers reported to date, and the methods described herein provide a reliable route for the engineering of additional split aptamers, dramatically advancing the potential substrate scope of DNA assembly based biosensors.

  17. Internal modifications to reduce pollutant emissions from marine engines. A numerical approach

    Directory of Open Access Journals (Sweden)

    M.I. Lamas

    2013-12-01

    Full Text Available Taking into account the increasingly stringent legislation on emissions from marine engines, this work aims to analyze several internal engine modifications to reduce NOx (nitrogen oxides and other pollutants. To this end, a numerical model was employed to simulate the operation cycle and characterize the exhaust gas composition. After a preliminary validation process was carried out using experimental data from a four-stroke, medium-speed marine engine, the numerical model was employed to study the influence of several internal modifications, such as water addition from 0 to 100% water to fuel ratios, exhaust gas recirculation from 0 to 100% EGR rates, modification of the overlap timing from 60 to 120°, modification of the intake valve closing from 510 to 570°, and modification of the cooling water temperature from 70 to 90 °C. NOx was reduced by nearly 100%. As expected, it was found that, by lowering the combustion temperature, there is a notable reduction in NOx, but an increase in CO (carbon monoxide, HC (hydrocarbons and consumption.

  18. Internal modifications to reduce pollutant emissions from marine engines. A numerical approach

    Science.gov (United States)

    Lamas, M. I.; Rodríguez, C. G.; Rodríguez, J. D.; Telmo, J.

    2013-12-01

    Taking into account the increasingly stringent legislation on emissions from marine engines, this work aims to analyze several internal engine modifications to reduce NOx (nitrogen oxides) and other pollutants. To this end, a numerical model was employed to simulate the operation cycle and characterize the exhaust gas composition. After a preliminary validation process was carried out using experimental data from a four-stroke, medium-speed marine engine, the numerical model was employed to study the influence of several internal modifications, such as water addition from 0 to 100% water to fuel ratios, exhaust gas recirculation from 0 to 100% EGR rates, modification of the overlap timing from 60 to 120°, modification of the intake valve closing from 510 to 570°, and modification of the cooling water temperature from 70 to 90 oC. NOx was reduced by nearly 100%. As expected, it was found that, by lowering the combustion temperature, there is a notable reduction in NOx, but an increase in CO (carbon monoxide), HC (hydrocarbons) and consumption.

  19. A Possible Approach for Addressing Neglected Human Factors Issues of Systems Engineering

    Science.gov (United States)

    Johnson, Christopher W.; Holloway, C. Michael

    2011-01-01

    The increasing complexity of safety-critical applications has led to the introduction of decision support tools in the transportation and process industries. Automation has also been introduced to support operator intervention in safety-critical applications. These innovations help reduce overall operator workload, and filter application data to maximize the finite cognitive and perceptual resources of system operators. However, these benefits do not come without a cost. Increased computational support for the end-users of safety-critical applications leads to increased reliance on engineers to monitor and maintain automated systems and decision support tools. This paper argues that by focussing on the end-users of complex applications, previous research has tended to neglect the demands that are being placed on systems engineers. The argument is illustrated through discussing three recent accidents. The paper concludes by presenting a possible strategy for building and using highly automated systems based on increased attention by management and regulators, improvements in competency and training for technical staff, sustained support for engineering team resource management, and the development of incident reporting systems for infrastructure failures. This paper represents preliminary work, about which we seek comments and suggestions.

  20. System engineering approach in the EU Test Blanket Systems Design Integration

    International Nuclear Information System (INIS)

    Panayotov, D.; Sardain, P.; Boccaccini, L.V.; Salavy, J.-F.; Cismondi, F.; Jourd'Heuil, L.

    2011-01-01

    The complexity of the Test Blanket Systems demands diverse and comprehensive integration activities. Test Blanket Modules - Consortia of Associates (TBM-CA) applies the system engineering methods in all stages of the Test Blanket System (TBS) design integration. Completed so far integration engineering tasks cover among others status and initial set of TBS operating parameters; list of codes, standards and regulations related to TBS; planning of the TBS interfaces and baseline documentation. Most of the attention is devoted to the establishment the Helium-Cooled Lithium Lead (HCLL) and Helium-Cooled Pebble Bed Lead (HCPB) TBS configuration baseline, TBS break down into sub-systems, identification, definition and management of the internal and external interfaces, development of the TBS plant break down structure (PBS), establishment and management of the required TBS baseline documentation infrastructure. Break down of the TBS into sub-systems that is crucial for the further design and interfaces' management has been selected considering several options and using specific evaluation criteria. Process of the TBS interfaces management covers the planning, definition and description, verification and review, non-conformances and deviations, and modification and improvement processes. Process of interfaces review is developed, identifying the actors, input, activities and output of the review. Finally the relations and interactions of system engineering processes with TBM configuration management and TBM-CA Quality Management System are discussed.

  1. An approach to architecture 3D scaffold with interconnective microchannel networks inducing angiogenesis for tissue engineering.

    Science.gov (United States)

    Sun, Jiaoxia; Wang, Yuanliang; Qian, Zhiyong; Hu, Chenbo

    2011-11-01

    The angiogenesis of 3D scaffold is one of the major current limitations in clinical practice tissue engineering. The new strategy of construction 3D scaffold with microchannel circulation network may improve angiogenesis. In this study, 3D poly(D: ,L: -lactic acid) scaffolds with controllable microchannel structures were fabricated using sacrificial sugar structures. Melt drawing sugar-fiber network produced by a modified filament spiral winding method was used to form the microchannel with adjustable diameters and porosity. This fabrication process was rapid, inexpensive, and highly scalable. The porosity, microchannel diameter, interconnectivity and surface topographies of the scaffold were characterized by scanning electron microscopy. Mechanical properties were evaluated by compression tests. The mean porosity values of the scaffolds were in the 65-78% and the scaffold exhibited microchannel structure with diameter in the 100-200 μm range. The results showed that the scaffolds exhibited an adequate porosity, interconnective microchannel network, and mechanical properties. The cell culture studies with endothelial cells (ECs) demonstrated that the scaffold allowed cells to proliferate and penetrate into the volume of the entire scaffold. Overall, these findings suggest that the fabrication process offers significant advantages and flexibility in generating a variety of non-cytotoxic tissue engineering scaffolds with controllable distributions of porosity and physical properties that could provide the necessary physical cues for ECs and further improve angiogenesis for tissue engineering.

  2. A Comparison of Hybrid Approaches for Turbofan Engine Gas Path Fault Diagnosis

    Science.gov (United States)

    Lu, Feng; Wang, Yafan; Huang, Jinquan; Wang, Qihang

    2016-09-01

    A hybrid diagnostic method utilizing Extended Kalman Filter (EKF) and Adaptive Genetic Algorithm (AGA) is presented for performance degradation estimation and sensor anomaly detection of turbofan engine. The EKF is used to estimate engine component performance degradation for gas path fault diagnosis. The AGA is introduced in the integrated architecture and applied for sensor bias detection. The contributions of this work are the comparisons of Kalman Filters (KF)-AGA algorithms and Neural Networks (NN)-AGA algorithms with a unified framework for gas path fault diagnosis. The NN needs to be trained off-line with a large number of prior fault mode data. When new fault mode occurs, estimation accuracy by the NN evidently decreases. However, the application of the Linearized Kalman Filter (LKF) and EKF will not be restricted in such case. The crossover factor and the mutation factor are adapted to the fitness function at each generation in the AGA, and it consumes less time to search for the optimal sensor bias value compared to the Genetic Algorithm (GA). In a word, we conclude that the hybrid EKF-AGA algorithm is the best choice for gas path fault diagnosis of turbofan engine among the algorithms discussed.

  3. ¿Do Mountain Microorganisms (MM Really Work as a Biofertilization Strategy? A Biosystems Engineering Approach

    Directory of Open Access Journals (Sweden)

    Steven Umaña

    2017-06-01

    Full Text Available The use of microorganisms for engineering applications, in particular from a context of tropical biosystems engineering, has been useful to quantify important variables that are needed to understand the dynamics of edaphic systems in these areas. The current study is framed within those efforts and has been designed to document the potential of mountain microorganisms for soil biofertilization activities by using a standard experiment with two short-cycle plants. For that, an experiment including three biofertilization irrigation treatments, associated with three retention times in a bioreactor, were selected and compared with a control that was irrigated only with water. After harvesting, a series of biological, chemical, structural, and agronomic tests were conducted on both the soil and the cultivated plants to determine potential differences in the effect of the experimental treatments. Results indicated that a bioreactor retention time, close to two weeks, was the best treatment in terms of positive and significant impact on the biological activity, soil chemical properties, and quality of crops. Such significant differences seem to be related with a more active soil biosystem for the associated treatment. This demonstrates that biofertilization with mountain microorganisms works; but it also suggests that a series of engineering parameters should be studied to optimize such low cost and sustainable fertilization method.

  4. Implementation of an industrial systems-engineering approach to reduce the incidence of methicillin-resistant Staphylococcus aureus infection.

    Science.gov (United States)

    Muder, Robert R; Cunningham, Candace; McCray, Ellesha; Squier, Cheryl; Perreiah, Peter; Jain, Rajiv; Sinkowitz-Cochran, Ronda L; Jernigan, John A

    2008-08-01

    To measure the effectiveness of an industrial systems-engineering approach to a methicillin-resistant Staphylococcus aureus (MRSA) prevention program. Before-after intervention study. An intensive care unit (ICU) and a surgical unit that was not an ICU in the Pittsburgh Veterans Administration hospital. All patients admitted to the study units. We implemented an MRSA infection control program that consisted of the following 4 elements: (1) the use of standard precautions for all patient contact, with emphasis on hand hygiene; (2) the use of contact precautions for interactions with patients known to be infected or colonized with MRSA; (3) the use of active surveillance cultures to identify patients who were asymptomatically colonized with MRSA; and (4) use of an industrial systems-engineering approach, the Toyota Production System, to facilitate consistent and reliable adherence to the infection control program. The rate of healthcare-associated MRSA infection in the surgical unit decreased from 1.56 infections per 1,000 patient-days in the 2 years before the intervention to 0.63 infections per 1,000 patient-days in the 4 years after the intervention (a 60% reduction; P = .003). The rate of healthcare-associated MRSA infection in the ICU decreased from 5.45 infections per 1,000 patient-days in the 2 years before to the intervention to 1.35 infections per 1,000 patient-days in the 3 years after the intervention (a 75% reduction; P = .001). The combined estimate for reduction in the incidence of infection after the intervention in the 2 units was 68% (95% confidence interval, 50%-79%; P systems-engineering approach can be adapted to facilitate consistent and reliable adherence to MRSA infection prevention practices in healthcare facilities.

  5. Minimally-invasive implantation of living tissue engineered heart valves: a comprehensive approach from autologous vascular cells to stem cells.

    Science.gov (United States)

    Schmidt, Dörthe; Dijkman, Petra E; Driessen-Mol, Anita; Stenger, Rene; Mariani, Christine; Puolakka, Arja; Rissanen, Marja; Deichmann, Thorsten; Odermatt, Bernhard; Weber, Benedikt; Emmert, Maximilian Y; Zund, Gregor; Baaijens, Frank P T; Hoerstrup, Simon P

    2010-08-03

    The aim of this study was to demonstrate the feasibility of combining the novel heart valve replacement technologies of: 1) tissue engineering; and 2) minimally-invasive implantation based on autologous cells and composite self-expandable biodegradable biomaterials. Minimally-invasive valve replacement procedures are rapidly evolving as alternative treatment option for patients with valvular heart disease. However, currently used valve substitutes are bioprosthetic and as such have limited durability. To overcome this limitation, tissue engineering technologies provide living autologous valve replacements with regeneration and growth potential. Trileaflet heart valves fabricated from biodegradable synthetic scaffolds, integrated in self-expanding stents and seeded with autologous vascular or stem cells (bone marrow and peripheral blood), were generated in vitro using dynamic bioreactors. Subsequently, the tissue engineered heart valves (TEHV) were minimally-invasively implanted as pulmonary valve replacements in sheep. In vivo functionality was assessed by echocardiography and angiography up to 8 weeks. The tissue composition of explanted TEHV and corresponding control valves was analyzed. The transapical implantations were successful in all animals. The TEHV demonstrated in vivo functionality with mobile but thickened leaflets. Histology revealed layered neotissues with endothelialized surfaces. Quantitative extracellular matrix analysis at 8 weeks showed higher values for deoxyribonucleic acid, collagen, and glycosaminoglycans compared to native valves. Mechanical profiles demonstrated sufficient tissue strength, but less pliability independent of the cell source. This study demonstrates the principal feasibility of merging tissue engineering and minimally-invasive valve replacement technologies. Using adult stem cells is successful, enabling minimally-invasive cell harvest. Thus, this new technology may enable a valid alternative to current bioprosthetic devices

  6. A new technology perspective and engineering tools approach for large, complex and distributed mission and safety critical systems components

    Science.gov (United States)

    Carrio, Miguel A., Jr.

    1988-01-01

    Rapidly emerging technology and methodologies have out-paced the systems development processes' ability to use them effectively, if at all. At the same time, the tools used to build systems are becoming obsolescent themselves as a consequence of the same technology lag that plagues systems development. The net result is that systems development activities have not been able to take advantage of available technology and have become equally dependent on aging and ineffective computer-aided engineering tools. New methods and tools approaches are essential if the demands of non-stop and Mission and Safety Critical (MASC) components are to be met.

  7. Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus

    Science.gov (United States)

    Cucchiarini, M.; McNulty, A.L.; Mauck, R.L.; Setton, L.A.; Guilak, F.; Madry, H.

    2017-01-01

    SUMMARY Meniscal lesions are common problems in orthopaedic surgery and sports medicine, and injury or loss of the meniscus accelerates the onset of knee osteoarthritis. Despite a variety of therapeutic options in the clinics, there is a critical need for improved treatments to enhance meniscal repair. In this regard, combining gene-, cell-, and tissue engineering-based approaches is an attractive strategy to generate novel, effective therapies to treat meniscal lesions. In the present work, we provide an overview of the tools currently available to improve meniscal repair and discuss the progress and remaining challenges for potential future translation in patients. PMID:27063441

  8. The Formation of Conservation-Based Behaviour of Mechanical Engineering Students through Contextual Learning Approach

    Science.gov (United States)

    Sudarman; Djuniadi; Sutopo, Yeri

    2017-01-01

    This study was aimed to figure out: (1) the implementation of contextual learning approaches; (2) the learning outcome of conservation education using contextual approach on the internship program preparation class; (3) the conservation-based behaviour of the internship program participants; (4) the contribution of conservation education results…

  9. Theoretical and Practical Approach of Connecting the Ecotourist Offer of the Special Nature Reserve of Zasavica (Serbia with the Tourist Offer of the Surrounding Village Settlements

    Directory of Open Access Journals (Sweden)

    Dragan Dolinaj

    2009-06-01

    Full Text Available Pannonian basin was once covered by vast alluvial plains with patches of marsh, swamp, pan and prairie. With Holocene changes in climate, marshes have withdrawn and in the last couple hundreds of years they were pushed out by developing agricultural areas. The Nature Reserve Zasavica keeps the remains of former marshes and swamps on the territory of Vojvodina. One of the ways for providing necessary financial support for the reserve protection is development of ecotourist activities in the Zasavica region. Its biodiversity and numerous endangered species (Umbra krameri, Nymphaca alba, Numphar luteum, Stratiotes aloides, Acorus calamus, Buteo butes, Haliateetus albicilla, Lutra lutra, Castor fiber... could be the basis for tourist valorization of the Reserve. It is also necessary to conduct analyses of the impact of tourism on endangered species and confirm sustainability of those activities. The lack of accommodation capacities could be supplemented by the development of the tourist offer of the nearby countryside. This way the village tourism would enrich its offer with visits to the nature reserve. Such tourism activities would contribute towards the development of local communities and the improvement of the standard of living. Since the villages and the reserve are already territorially intertwined, their further tourist cooperation would lead to knowledge transfer and local people would have a better understanding of the protection of the Special Nature Reserve Zasavica.

  10. Geologic constraints on the upper limits of reserve growth

    Science.gov (United States)

    Stanley, Richard G.

    2001-01-01

    For many oil and gas fields, estimates of ultimate recovery (the sum of cumulative production plus estimated reserves) tend to increase from one year to the next, and the gain is called reserve growth. Forecasts of reserve growth by the U.S. Geological Survey rely on statistical analyses of historical records of oil and gas production and estimated reserves. The preproposal in this Open-File Report suggests that this traditional petroleum–engineering approach to reserve growth might be supplemented, or at least better understood, by using geological data from individual oil and gas fields, 3–D modeling software, and standard volumetric techniques to estimate in–place volumes of oil and gas. Such estimates, in turn, can be used to constrain the upper limits of reserve growth and ultimate recovery from those fields.

  11. Mathematics Learning Process with Science, Technology, Engineering, Mathematics (STEM) Approach in Indonesia

    Science.gov (United States)

    Milaturrahmah, N.; Mardiyana, M.; Pramudya, I.

    2017-09-01

    STEM approach has been widely applied in developed and developing countries. In Indonesia, the STEM approach has not been widely used. Application of STEM approach in each country is different according to the needs of the State itself. This study aims to describe the process of learning mathematics with STEM approach in Indonesia which includes the readiness of teachers before the learning process, implementation of learning, evaluation of learning and to describe the obstacles experienced by teachers during the learning process with STEM approach in Indonesia. This research is descriptive qualitative research. The subject of the research is the mathematics teacher. The technique used in taking the subject is purposive sampling. Methods of data collection is by observation and interview. Technique to validate data with time triangulation. Data analysis techniques used consist of data reduction, data presentation, and conclusion. The results of this study are the learning process of mathematics with STEM approach includes preparatory aspects before learning, learning implementation aspect consisting of preliminary, core and closing stage, and evaluation aspect. The obstacles experienced by teachers in applying STEM approach to learning mathematics is looking for real life and material practice on a material.

  12. Integrating security issues in nuclear engineering curriculum in Indonesia. Classical vs policy approaches

    International Nuclear Information System (INIS)

    Putero, Susetyo Hario; Rosita, Widya; Sihana, Fnu; Ferdiansjah; Santosa, Haryono Budi; Muharini, Anung

    2015-01-01

    Recently, risk management for nuclear facilities becomes more complex due to security issue addressed by IAEA. The harmonization between safety, safeguards and security is still questionable. It also challenges to nuclear engineering curriculum in the world how to appropriately lecture the new issue. This paper would like to describe how to integrate this issue in developing nuclear engineering curriculum in Indonesia. Indonesia has still no nuclear power plant, but there are 3 research reactors laid in Indonesia. As addition, there are several hospitals and industries utilizing radioisotopes in their activities. The knowledge about nuclear security of their staffs is also not enough for handling radioactive material furthermore the security officers. Universitas Gadjah Mada (UGM) is the only university in Indonesia offering nuclear engineering program, as consequently the university should actively play the role in overcoming this issue not only in Indonesia, but also in Southeast Asia. In the other hand, students has to have proper knowledge in order to complete in the global nuclear industry. After visited several universities in USA and participated in INSEN meeting, we found that most of universities in the world anticipate this issue by giving the student courses related to policy (non-technical) study based on IAEA NSS 12. In the other hand, the rest just make nuclear security as a case study on their class. Furthermore, almost all of programs are graduate level. UGM decided to enhance several present related undergraduate courses with security topics as first step to develop the awareness of student to nuclear security. The next (curriculum 2016) is to integrate security topics into the entire of curriculum including designing a nuclear security elective course for undergraduate level. The first trial has successfully improved the student knowledge and awareness on nuclear security. (author)

  13. Biomimetic multidirectional scaffolds for zonal osteochondral tissue engineering via a lyophilization bonding approach.

    Science.gov (United States)

    Clearfield, Drew; Nguyen, Andrew; Wei, Mei

    2018-04-01

    The zonal organization of osteochondral tissue underlies its long term function. Despite this, tissue engineering strategies targeted for osteochondral repair commonly rely on the use of isotropic biomaterials for tissue reconstruction. There exists a need for a new class of highly biomimetic, anisotropic scaffolds that may allow for the engineering of new tissue with zonal properties. To address this need, we report the facile production of monolithic multidirectional collagen-based scaffolds that recapitulate the zonal structure and composition of osteochondral tissue. First, superficial and osseous zone-mimicking scaffolds were fabricated by unidirectional freeze casting collagen-hyaluronic acid and collagen-hydroxyapatite-containing suspensions, respectively. Following their production, a lyophilization bonding process was used to conjoin these scaffolds with a distinct collagen-hyaluronic acid suspension mimicking the composition of the transition zone. Resulting matrices contained a thin, highly aligned superficial zone that interfaced with a cellular transition zone and vertically oriented calcified cartilage and osseous zones. Confocal microscopy confirmed a zone-specific localization of hyaluronic acid, reflecting the depth-dependent increase of glycosaminoglycans in the native tissue. Poorly crystalline, carbonated hydroxyapatite was localized to the calcified cartilage and osseous zones and bordered the transition zone. Compressive testing of hydrated scaffold zones confirmed an increase of stiffness with scaffold depth, where compressive moduli of chondral and osseous zones fell within or near ranges conducive for chondrogenesis or osteogenesis of mesenchymal stem cells. With the combination of these biomimetic architectural and compositional cues, these multidirectional scaffolds hold great promise for the engineering of zonal osteochondral tissue. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 948-958, 2018. © 2017 Wiley Periodicals

  14. Cold flow simulation of an internal combustion engine with vertical valves using layering approach

    Science.gov (United States)

    Martinas, G.; Cupsa, O. S.; Stan, L. C.; Arsenie, A.

    2015-11-01

    Complying with emission requirements and fuel consumption efficiency are the points which drive any development of internal combustion engine. Refinement of the process of combustion and mixture formation, together with in-cylinder flow refinement, is a requirement, valves and piston bowl and intake exhaust port design optimization is essential. In order to reduce the time for design optimization cycle it is used Computational Fluid Dynamics (CFD). Being time consuming and highly costly caring out of experiment using flow bench testing this methods start to become less utilized. Air motion inside the intake manifold is one of the important factors, which govern the engine performance and emission of multi-cylinder diesel engines. Any cold flow study on IC is targeting the process of identifying and improving the fluid flow inside the ports and the combustion chamber. This is only the base for an optimization process targeting to increase the volume of air accessing the combustion space and to increase the turbulence of the air at the end of the compression stage. One of the first conclusions will be that the valve diameter is a fine tradeoff between the need for a bigger diameter involving a greater mass of air filling the cylinder, and the need of a smaller diameter in order to reduce the blind zone. Here there is room for optimization studies. The relative pressure indicates a suction effect coming from the moving piston. The more the shape of the inlet port is smoother and the diameter of the piston is bigger, the aerodynamic resistance of the geometry will be smaller so that the difference of inlet port pressure and the pressure near to piston face will be smaller. Here again there is enough room for more optimization studies.

  15. A study into first-year engineering education success using a rigorous mixed methods approach

    DEFF Research Database (Denmark)

    van den Bogaard, M.E.D.; de Graaff, Erik; Verbraek, Alexander

    2015-01-01

    The aim of this paper is to combine qualitative and quantitative research methods into rigorous research into student success. Research methods have weaknesses that can be overcome by clever combinations. In this paper we use a situated study into student success as an example of how methods...... reinforce the other. The aim of the study is to develop a model for first year engineering student success that can inform policy makers on possible effects of policies. Students from two cohorts were interviewed in two separate studies and the results were used to make a model, which in turn was tested...

  16. Meteorological and engineering approach to the regionalization of tornado wind criteria for nuclear power plant design

    International Nuclear Information System (INIS)

    1975-01-01

    Data on general meteorological factors governing tornado frequency and intensity in various locations throughout the USA are revised. A climatological model of multiple outbreak and long track tornadoes and the relation between the speed of a hurricane and the frequency of tornado occurrence over land and sea are discussed. Data from a structural engineering assessment of tornado damage are summarized and applications of the data for the development of design criteria for buildings and nuclear power plants to minimize tornado damage are suggested. It was concluded that it is very difficult to predict tornado risk and alternate methods and areas of study are presented for consideration

  17. A methodological approach of 'environmental engineering' for the rescue and protection of a territory

    International Nuclear Information System (INIS)

    Cautilli, F.; Polizzano, C.; Tassoni, E.; Zarlenga, F.

    1989-02-01

    In this report the methodological process, that should be followed when an environmental protection and restoration problem is dealt with, is described. Moreover the actions that 'the environmental engineer' has to carry out to study every multidisciplinary problem on territory protection and restoration are synthesized, keeping in mind that the territory knowledge and the geological hazard specification are the essential bases for research work. Finally, some typical territory protection actions against the hydrogeological failures, the quarry excavation activity and the hazardous waste disposal impact, are briefly described. (author)

  18. Using formal methods to teach software engineering: a tool-based approach

    OpenAIRE

    Ciancarini, P.; Mascolo, C.

    1998-01-01

    In this paper we describe and review the course plan and syllabus we use in a course on formal methods in software engineering currently included in the degree in Informatics of the Faculty of Sciences at the University of Bologna. The course matches the theory of formal methods with their practice based on actual tool usage. In fact, the course is centered upon a project whose main goal is to let students learn some formal specification techniques, all supported by specific tools. The studen...

  19. A personalized and control systems engineering conceptual approach to target childhood anxiety in the contexts of cultural diversity.

    Science.gov (United States)

    Pina, Armando A; Holly, Lindsay E; Zerr, Argero A; Rivera, Daniel E

    2014-01-01

    In the child and adolescent anxiety area, some progress has been made to develop evidence-based prevention protocols, but less is known about how to best target these problems in children and families of color. In general, data show differential program effects with some minority children benefiting significantly less. Our preliminary data, however, show promise and suggest cultural parameters to consider in the tailoring process beyond language and cultural symbols. It appears that a more focused approach to culture might help activate intervention components and its intended effects by focusing, for example, on the various facets of familismo when working with some Mexican parents. However, testing the effects and nuances of cultural adaption vis-à-vis a focused personalized approach is methodologically challenging. For this reason, we identify control systems engineering design methods and provide example scenarios relevant to our data and recent intervention work.

  20. A Taguchi PCA fuzzy-based approach for the multi-objective extended optimization of a miniature optical engine

    International Nuclear Information System (INIS)

    Fan Yichin; Tzeng Yihfong; Li Sixiang

    2008-01-01

    The paper proposes a hybrid approach, integrating a combination of Taguchi methods, principal component analysis (PCA) and fuzzy theory for the extended optimization of multiple quality characteristics in optimization experiments of non-image optics; a miniature light emitting diode pocket-sized projection display system is demonstrated in this research as an optimization sample. Traditionally, the performance of projector optics can be evaluated by modulation transfer function and its optimization method is DLS (damped least square). Comparatively, light efficiency and uniformity play a part in non-image optics where the optimized method is based on the concept of non-sequential rays; for example, in the optical engine of a projector, which demands better light efficiency and uniformity. The DLS method is occasionally employed in the optimization of non-image optics such as optical engines, but it is sometimes sensitive to the number of rays employed and some over-optimization problems. In this research we propose as an alternative method to optimize in an extended way the optical engine of a miniature projector. Control factors were checked and then repeatedly examined before the experiments started. In the experiment, optimization works through an L18 orthogonal array. Finally, this proposed optimization work shows good success for the optimization of non-image optical engines because this method is less sensitive to the number of non-sequential rays. Compared with the initial design, the optimized parameter design is able to improve the luminous flux by 11.46 dB, the illumination uniformity by 3.14 and the packing size by 1.125 dB

  1. Simple engineering design for complex thermoelectric generators based on reduced current approach

    DEFF Research Database (Denmark)

    Wijesooriyage, Waruna Dissanayaka; Rezaniakolaei, Alireza; Rosendahl, Lasse

    2015-01-01

    Thermoelectric generators (TEGs) are niche candidate for the field of energy management as electrical generator devices. Generally, comprehensive and accurate design techniques for TEGs (thermoelectric generators), such as reduced current approach (RCA), are complex and time consuming processes. ...

  2. Safety of genetically engineered foods: approaches to assessing unintended health effects

    National Research Council Canada - National Science Library

    Committee on Identifying and Assessing Unintended Effects of Genetically Engineered Foods on Human Health

    2004-01-01

    .... It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues...

  3. A DMAIC approach for process capability improvement an engine crankshaft manufacturing process

    Science.gov (United States)

    Sharma, G. V. S. S.; Rao, P. Srinivasa

    2014-05-01

    The define-measure-analyze-improve-control (DMAIC) approach is a five-strata approach, namely DMAIC. This approach is the scientific approach for reducing the deviations and improving the capability levels of the manufacturing processes. The present work elaborates on DMAIC approach applied in reducing the process variations of the stub-end-hole boring operation of the manufacture of crankshaft. This statistical process control study starts with selection of the critical-to-quality (CTQ) characteristic in the define stratum. The next stratum constitutes the collection of dimensional measurement data of the CTQ characteristic identified. This is followed by the analysis and improvement strata where the various quality control tools like Ishikawa diagram, physical mechanism analysis, failure modes effects analysis and analysis of variance are applied. Finally, the process monitoring charts are deployed at the workplace for regular monitoring and control of the concerned CTQ characteristic. By adopting DMAIC approach, standard deviation is reduced from 0.003 to 0.002. The process potential capability index ( C P) values improved from 1.29 to 2.02 and the process performance capability index ( C PK) values improved from 0.32 to 1.45, respectively.

  4. An Axiomatic Design Approach of Nanofluid-Engineered Nuclear Safety Features for Generation III+ React

    International Nuclear Information System (INIS)

    Bang, In Cheol; Heo, Gyun Young; Jeong, Yong Hoon; Heo, Sun

    2009-01-01

    A variety of Generation III/III+ reactor designs featuring enhanced safety and improved economics are being proposed by nuclear power industries around the world to solve the future energy supply shortfall. Nanofluid coolants showing an improved thermal performance are being considered as a new key technology to secure nuclear safety and economics. However, it should be noted that there is a lack of comprehensible design works to apply nanofluids to Generation III+ reactor designs. In this work, the review of accident scenarios that consider expected nanofluid mechanisms is carried out to seek detailed application spots. The Axiomatic Design (AD) theory is then applied to systemize the design of nanofluid-engineered nuclear safety systems such as Emergency Core Cooling System (ECCS) and External Reactor Vessel Cooling System (ERVCS). The various couplings between Gen-III/III+ nuclear safety features and nanofluids are investigated and they try to be reduced from the perspective of the AD in terms of prevention/mitigation of severe accidents. This study contributes to the establishment of a standard communication protocol in the design of nanofluid-engineered nuclear safety systems

  5. A quick, simplified approach to the evaluation of combustion rate from an internal combustion engine indicator diagram

    Directory of Open Access Journals (Sweden)

    Tomić Miroljub V.

    2008-01-01

    Full Text Available In this paper a simplified procedure of an internal combustion engine in-cylinder pressure record analysis has been presented. The method is very easy for programming and provides quick evaluation of the gas temperature and the rate of combustion. It is based on the consideration proposed by Hohenberg and Killman, but enhances the approach by involving the rate of heat transferred to the walls that was omitted in the original approach. It enables the evaluation of the complete rate of heat released by combustion (often designated as “gross heat release rate” or “fuel chemical energy release rate”, not only the rate of heat transferred to the gas (which is often designated as “net heat release rate”. The accuracy of the method has been also analyzed and it is shown that the errors caused by the simplifications in the model are very small, particularly if the crank angle step is also small. A several practical applications on recorded pressure diagrams taken from both spark ignition and compression ignition engine are presented as well.

  6. Educational analysis of a first year engineering physics experiment on standing waves: based on the ACELL approach

    Energy Technology Data Exchange (ETDEWEB)

    Bhathal, Ragbir [School of Engineering, University of Western Sydney, NSW1797 (Australia); Sharma, Manjula D; Mendez, Alberto [School of Physics, University of Sydney, NSW 2006 (Australia)], E-mail: r.bhathal@uws.edu.au

    2010-01-15

    This paper describes an educational analysis of a first year physics experiment on standing waves for engineering students. The educational analysis is based on the ACELL (Advancing Chemistry by Enhancing Learning in the Laboratory) approach which includes a statement of educational objectives and an analysis of student learning experiences. The experiment is likely to be found in many physics departments, hence is appropriate to illustrate the ACELL approach in physics. The concepts associated with standing waves are difficult; however, they are underpinned by mathematical formulation which lend themselves to be visualized in experiments. The challenge is to strike a balance between these two for the particular student cohort. In this study, this balance is achieved by using simple equipment and providing appropriate scaffolds for students to associate abstract concepts with concrete visuals. In essence the experiment is designed to adequately manage cognitive resources. Students work in pairs and are questioned and assisted by demonstrators and academic staff during a 2 h practical class. Students were surveyed using the ACELL instrument. Analysis of the data showed that by completing the practical students felt that their understanding of physics had increased. Furthermore, students could see the relevance of this experiment to their engineering studies and that it provided them with an opportunity to take responsibility for their own learning. Overall they had a positive learning experience. In short there is a lot of dividend from a small outlay of resources.

  7. Educational analysis of a first year engineering physics experiment on standing waves: based on the ACELL approach

    International Nuclear Information System (INIS)

    Bhathal, Ragbir; Sharma, Manjula D; Mendez, Alberto

    2010-01-01

    This paper describes an educational analysis of a first year physics experiment on standing waves for engineering students. The educational analysis is based on the ACELL (Advancing Chemistry by Enhancing Learning in the Laboratory) approach which includes a statement of educational objectives and an analysis of student learning experiences. The experiment is likely to be found in many physics departments, hence is appropriate to illustrate the ACELL approach in physics. The concepts associated with standing waves are difficult; however, they are underpinned by mathematical formulation which lend themselves to be visualized in experiments. The challenge is to strike a balance between these two for the particular student cohort. In this study, this balance is achieved by using simple equipment and providing appropriate scaffolds for students to associate abstract concepts with concrete visuals. In essence the experiment is designed to adequately manage cognitive resources. Students work in pairs and are questioned and assisted by demonstrators and academic staff during a 2 h practical class. Students were surveyed using the ACELL instrument. Analysis of the data showed that by completing the practical students felt that their understanding of physics had increased. Furthermore, students could see the relevance of this experiment to their engineering studies and that it provided them with an opportunity to take responsibility for their own learning. Overall they had a positive learning experience. In short there is a lot of dividend from a small outlay of resources.

  8. Task to Training Matrix Design for Decommissioning Engineer on the basis of Systematic Approach to Training Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, Jeong Keun [KHNP, Ulsan (Korea, Republic of)

    2016-10-15

    In nuclear history, before Chernobyl Accident, Three Mile Island (TMI) Accident was the severest accident. For this reason, to resolve the disclosed or potential possibilities of nuclear accident, more than one hundred countermeasures were proposed by United States Nuclear Regulatory Commission (USNRC). Among various recommendations by USNRC, one suggestion was related to training aspect. It was Systematic Approach to Training (SAT) and this event was the initiation of SAT methodology in the world. In Korea, upcoming June 2017, Kori Unit-1 NPP is scheduled to be shut down and it will experience NPP decommissioning for the first time. Present study aims to establish concrete training foundation for NPP decommissioning engineers based on Systematic Approach to Training (SAT) methodology, in particular, Task to Training Matrix (TTM). The objective of this paper is to organize TTM on the basis of SAT for NPP decommissioning engineer. For this reason, eighteen tasks are yielded through Job and Task Analysis (JTA) process. After that, for the settlement of Task to Training Matrix (TTM), various data are determined such as element, condition, standard, knowledge and skill, learning objective and training setting. When it comes to training in nuclear industry, SAT methodology has been the unwavering principle in Korea since NPPs export to UAE.

  9. Engineering the path to higher-order thinking in elementary education: A problem-based learning approach for STEM integration

    Science.gov (United States)

    Rehmat, Abeera Parvaiz

    As we progress into the 21st century, higher-order thinking skills and achievement in science and math are essential to meet the educational requirement of STEM careers. Educators need to think of innovative ways to engage and prepare students for current and future challenges while cultivating an interest among students in STEM disciplines. An instructional pedagogy that can capture students' attention, support interdisciplinary STEM practices, and foster higher-order thinking skills is problem-based learning. Problem-based learning embedded in the social constructivist view of teaching and learning (Savery & Duffy, 1995) promotes self-regulated learning that is enhanced through exploration, cooperative social activity, and discourse (Fosnot, 1996). This quasi-experimental mixed methods study was conducted with 98 fourth grade students. The study utilized STEM content assessments, a standardized critical thinking test, STEM attitude survey, PBL questionnaire, and field notes from classroom observations to investigate the impact of problem-based learning on students' content knowledge, critical thinking, and their attitude towards STEM. Subsequently, it explored students' experiences of STEM integration in a PBL environment. The quantitative results revealed a significant difference between groups in regards to their content knowledge, critical thinking skills, and STEM attitude. From the qualitative results, three themes emerged: learning approaches, increased interaction, and design and engineering implementation. From the overall data set, students described the PBL environment to be highly interactive that prompted them to employ multiple approaches, including design and engineering to solve the problem.

  10. A New Approach in Applying Systems Engineering Tools and Analysis to Determine Hepatocyte Toxicogenomics Risk Levels to Human Health.

    Science.gov (United States)

    Gigrich, James; Sarkani, Shahryar; Holzer, Thomas

    2017-03-01

    There is an increasing backlog of potentially toxic compounds that cannot be evaluated with current animal-based approaches in a cost-effective and expeditious manner, thus putting human health at risk. Extrapolation of animal-based test results for human risk assessment often leads to different physiological outcomes. This article introduces the use of quantitative tools and methods from systems engineering to evaluate the risk of toxic compounds by the analysis of the amount of stress that human hepatocytes undergo in vitro when metabolizing GW7647 1 over extended times and concentrations. Hepatocytes are exceedingly connected systems that make it challenging to understand the highly varied dimensional genomics data to determine risk of exposure. Gene expression data of peroxisome proliferator-activated receptor-α (PPARα) 2 binding was measured over multiple concentrations and varied times of GW7647 exposure and leveraging mahalanombis distance to establish toxicity threshold risk levels. The application of these novel systems engineering tools provides new insight into the intricate workings of human hepatocytes to determine risk threshold levels from exposure. This approach is beneficial to decision makers and scientists, and it can help reduce the backlog of untested chemical compounds due to the high cost and inefficiency of animal-based models.

  11. A requirements engineering approach for improving the quality of diabetes education websites.

    Science.gov (United States)

    Shabestari, Omid; Roudsari, Abdul

    2011-01-01

    Diabetes Mellitus is a major chronic disease with multi-organ involvement and high-cost complications. Although it has been proved that structured education can control the risk of developing these complications, there is big room for improvement in the educational services for these patients. e-learning can be a good solution to fill this gap. Most of the current e-learning solutions for diabetes were designed by computer experts and healthcare professionals but the patients, as end-users of these systems, haven't been deeply involved in the design process. Considering the expectations of the patients, this article investigates a requirement engineering process comparing the level of importance given to different attributes of the e-learning by patients and healthcare professionals. The results of this comparison can be used for improving the currently developed online diabetes education systems.

  12. Engineering safe and secure cyber-physical systems the specification PEARL approach

    CERN Document Server

    Gumzej, Roman

    2016-01-01

    This book introduces the concept of holistic design and development of cyber physical systems to achieve their safe and secure operation. It shows that by following the standards for embedded system’s safety and using appropriate hardware and software components inherently safe system’s architectures can be devised and certified. While the standards already enable testing and certification of inherently safe and sound hardware, this is still not the case with software. The book demonstrates that Specification PEARL(SPEARL) addresses this issue and proposes appropriate solutions from the viewpoints of software engineering as well as concrete program components. By doing so it reduces the complexity of cyber physical systems design in an innovative way. Three ultimate goals are being followed in the course of defining this new PEARL standard, namely: 1. simplicity over complexity, 2. inherent real-time ability, and 3. conformity to safety integrity and security capability levels.

  13. Orthographic Software Modelling: A Novel Approach to View-Based Software Engineering

    Science.gov (United States)

    Atkinson, Colin

    The need to support multiple views of complex software architectures, each capturing a different aspect of the system under development, has been recognized for a long time. Even the very first object-oriented analysis/design methods such as the Booch method and OMT supported a number of different diagram types (e.g. structural, behavioral, operational) and subsequent methods such as Fusion, Kruchten's 4+1 views and the Rational Unified Process (RUP) have added many more views over time. Today's leading modeling languages such as the UML and SysML, are also oriented towards supporting different views (i.e. diagram types) each able to portray a different facets of a system's architecture. More recently, so called enterprise architecture frameworks such as the Zachman Framework, TOGAF and RM-ODP have become popular. These add a whole set of new non-functional views to the views typically emphasized in traditional software engineering environments.

  14. Unifying the Classical Approach with New Technologies: An Innovative Proposal for Teaching Mathematics in Engineering

    Directory of Open Access Journals (Sweden)

    Sergio Amat

    2015-08-01

    Full Text Available The aim of this paper is to present a teaching experience developed in the Polytechnic University of Cartagena and, more specifically, in the subject of Mathematical Methods Applied to Civil Engineering, that belongs to the Master Degree of Paths, Channels and Ports. Our classes were a mix between the traditional system and the new educational system. Moreover, we tried to adapt the evaluation process to the new European Framework for Higher Education. We have used videos developed by us and by students in our classes. We have noticed that the interest and motivation in class has grown. Also the grades have improved. We did a survey during this academic year and the results were strongly positive for both students and teachers.

  15. Conventional vs. micro-fat harvesting: how fat harvesting technique affects tissue-engineering approaches using adipose tissue-derived stem/stromal cells.

    Science.gov (United States)

    Alharbi, Ziyad; Opländer, Christian; Almakadi, Sultan; Fritz, Andrea; Vogt, Michael; Pallua, Norbert

    2013-09-01

    -harvested lipoaspirates were significantly higher. Moreover, a significant high adherence rate of isolated ASCs from the micro-fat-harvesting technique onto matrices was observed. The different sizes and surface/volume ratios of pieces of fatty tissue obtained by using different cannula sizes may be responsible for the observed differences and effects. Thus, micro-fat harvesting may be more suitable for tissue-engineering and -regenerative approaches using ASCs and collagen elastin matrices. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  16. Scaffold microstructure effects on functional and mechanical performance: Integration of theoretical and experimental approaches for bone tissue engineering applications.

    Science.gov (United States)

    Cavo, Marta; Scaglione, Silvia

    2016-11-01

    The really nontrivial goal of tissue engineering is combining all scaffold micro-architectural features, affecting both fluid-dynamical and mechanical performance, to obtain a fully functional implant. In this work we identified an optimal geometrical pattern for bone tissue engineering applications, best balancing several graft needs which correspond to competing design goals. In particular, we investigated the occurred changes in graft behavior by varying pore size (300μm, 600μm, 900μm), interpore distance (equal to pore size or 300μm fixed) and pores interconnection (absent, 45°-oriented, 90°-oriented). Mathematical considerations and Computational Fluid Dynamics (CFD) tools, here combined in a complete theoretical model, were carried out to this aim. Poly-lactic acid (PLA) based samples were realized by 3D printing, basing on the modeled architectures. A collagen (COL) coating was also realized on grafts surface and the interaction between PLA and COL, besides the protein contribution to graft bioactivity, was evaluated. Scaffolds were extensively characterized; human articular cells were used to test their biocompatibility and to evaluate the theoretical model predictions. Grafts fulfilled both the chemical and physical requirements. Finally, a good agreement was found between the theoretical model predictions and the experimental data, making these prototypes good candidates for bone graft replacements. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. An MDO augmented value-based systems engineering approach to holistic design decision-making: A satellite system case study

    Science.gov (United States)

    Kannan, Hanumanthrao

    The design of large scale complex engineered systems (LSCES) involves hundreds or thousands of designers making decisions at different levels of an organizational hierarchy. Traditionally, these LSCES are designed using systems engineering methods and processes, where the preferences of the stakeholder are flowed down the hierarchy using requirements that act as surrogates for preference. Current processes do not provide a system level guidance to subsystem designers. Value-Driven Design (VDD) offers a new perspective on complex system design, where the value preferences of the stakeholder are communicated directly through a decomposable value function, thereby providing a mechanism for improved system consistency. Requirements-based systems engineering approaches do not offer a mathematically rigorous way to capture the couplings present in the system. Multidisciplinary Design Optimization (MDO) was specifically developed to address couplings in both analysis and optimization thereby enabling physics-based consistency. MDO uses an objective function with constraints but does not provide a way to formulate the objective function. Current systems engineering processes do not provide a mathematically sound way to make design decisions when designers are faced with uncertainties. Designers tend to choose designs based on their preferences towards risky/uncertain designs, and past research has shown that there needs to be a consistency in risk preferences to enable design decisions that are consistent with stakeholder's desires. This research exploits the complimentary nature of VDD, MDO and Decision Analysis (DA) to enable consistency in communication of system preferences, consistency in physics and consistency in risk preferences. The role of VDD in this research is in formulating a value function for true preferences, whereas the role of MDO is to capture couplings and enable optimization using the value function, and the role of DA is to enable consistent design

  18. On the electrical breakdown of gaseous dielectrics-an engineering approach

    DEFF Research Database (Denmark)

    Pedersen, Aage

    1989-01-01

    the streamer criterion leads to applicable criteria for the onset of breakdown in air as well as in strongly electronegative gases. In this approach, a knowledge of the relevant ionization coefficients is not required, because these are replaced by parameters obtained from uniform-field Paschen curve data...

  19. Linking genes to microbial growth kinetics: an integrated biochemical systems engineering approach

    NARCIS (Netherlands)

    Koutinas, M.; Kiparissides, A.; Silva-Rocha, R.; Lam, M.C.; Martins Dos Santos, V.A.P.; Lorenzo, de V.; Pistikopoulos, E.N.; Mantalaris, A.

    2011-01-01

    The majority of models describing the kinetic properties of a microorganism for a given substrate are unstructured and empirical. They are formulated in this manner so that the complex mechanism of cell growth is simplified. Herein, a novel approach for modelling microbial growth kinetics is

  20. A model-based approach to associate complexity and robustness in engineering systems

    DEFF Research Database (Denmark)

    Göhler, Simon Moritz; D. Frey, Daniel; Howard, Thomas J.

    2017-01-01

    Ever increasing functionality and complexity of products and systems challenge development companies in achieving high and consistent quality. A model-based approach is used to investigate the relationship between system complexity and system robustness. The measure for complexity is based...